Caulobacter sp. K31, complete genome NC_010338 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 167647459 Common - NLP/P60 protein Caul_3497 10 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 167644480 Common - transcriptional regulator, LysR family Caul_0511 151 COG0583 LysR, Transcriptional regulator Transcription 167648179 Common - hypothetical protein Caul_4220 10 None None None 167648326 Common - DSBA oxidoreductase Caul_4371 80 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 167646778 Common - beta-lactamase domain protein Caul_2816 153 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 167648369 Common - 2-nitropropane dioxygenase NPD Caul_4414 104 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 167644554 Common - NIPSNAP family containing protein Caul_0586 18 None None None 167646675 Common - N-acylneuraminate-9-phosphate synthase Caul_2713 78 COG2089 SpsE, Sialic acid synthase Cell envelope biogenesis, outer membrane 167647846 Nonpathogen - plasmid stabilization system Caul_3886 6 COG3668 ParE, Plasmid stabilization system protein General function prediction only 167648713 Common - DNA mismatch endonuclease Vsr Caul_4758 71 COG3727 Vsr, DNA G:T-mismatch repair endonuclease DNA replication, recombination, and repair 167645446 Common - Cobyrinic acid ac-diamide synthase Caul_1481 139 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 167647649 Common - transcriptional regulator, TraR/DksA family Caul_3687 154 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 167648920 Nonpathogen - hypothetical protein Caul_4965 2 None None None 167646473 Common - ribosomal protein S18 Caul_2511 215 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 167645230 Common - protein of unknown function DUF1452 Caul_1265 26 COG5478 COG5478, Predicted small integral membrane protein Function unknown 167647177 Common - phosphoribosyltransferase Caul_3215 149 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 167647108 Common - Serine-type D-Ala-D-Ala carboxypeptidase Caul_3146 156 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 167644380 Nonpathogen - hypothetical protein Caul_0408 1 None None None 167645495 Nonpathogen - hypothetical protein Caul_1530 3 None None None 167644567 Nonpathogen - hypothetical protein Caul_0599 2 None None None 167644910 Nonpathogen - 17 kDa surface antigen Caul_0944 1 COG3133 SlyB, Outer membrane lipoprotein Cell envelope biogenesis, outer membrane 167644466 Common - protein of unknown function DUF453 Caul_0497 56 COG2828 COG2828, Uncharacterized protein conserved in bacteria Function unknown 167644776 Common - transcriptional regulator, TetR family Caul_0810 66 COG1309 AcrR, Transcriptional regulator Transcription 167647578 Common - Galactose 1-dehydrogenase Caul_3616 113 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 167646378 Nonpathogen - hypothetical protein Caul_2416 7 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 167645112 Nonpathogen - hypothetical protein Caul_1147 2 None None None 167645342 Common - type I phosphodiesterase/nucleotide pyrophosphatase Caul_1377 17 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 167645613 Common - protease Do Caul_1649 223 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 167644585 Common - MCP methyltransferase, CheR-type Caul_0617 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 167647609 Common - GCN5-related N-acetyltransferase Caul_3647 12 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 167648902 Common - cation diffusion facilitator family transporter Caul_4947 169 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 167645929 Nonpathogen - hypothetical protein Caul_1965 1 None None None 167648386 Common - HI0933 family protein Caul_4431 134 COG2081 COG2081, Predicted flavoproteins General function prediction only 167649027 Common - 2-polyprenylphenol 6-hydroxylase Caul_5072 181 COG0661 AarF, Predicted unusual protein kinase General function prediction only 167646700 Common - periplasmic binding protein Caul_2738 74 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 167644243 Common - hypothetical protein Caul_0271 8 None None None 167646239 Common - hypothetical protein Caul_2277 15 COG5639 COG5639, Uncharacterized conserved small protein Function unknown 167644328 Common - ABC transporter related Caul_0356 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 167645451 Nonpathogen - hypothetical protein Caul_1486 1 None None None 167645420 Common - protein of unknown function DUF541 Caul_1455 21 COG2968 COG2968, Uncharacterized conserved protein Function unknown 167648151 Common - pilus (Caulobacter type) biogenesis lipoprotein CpaD Caul_4192 15 COG5461 COG5461, Type IV pili component Cell motility and secretion 167647170 Common - GCN5-related N-acetyltransferase Caul_3208 32 COG3393 COG3393, Predicted acetyltransferase General function prediction only 167647656 Nonpathogen - hypothetical protein Caul_3694 1 None None None 167647375 Nonpathogen - hypothetical protein Caul_3413 1 None None None 167647036 Nonpathogen - hypothetical protein Caul_3074 1 None None None 167647618 Nonpathogen - lipoprotein, putative Caul_3656 1 None None None 167644016 Common - Lysine exporter protein (LYSE/YGGA) Caul_0043 124 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 167648360 Common - cytochrome P450 Caul_4405 80 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 167646214 Common - hypothetical protein Caul_2252 26 COG3843 VirD2, Type IV secretory pathway, VirD2 components (relaxase) Intracellular trafficking and secretion 167648297 Common - NUDIX hydrolase Caul_4342 98 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 167646919 Common - major facilitator superfamily MFS_1 Caul_2957 141 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 167644069 Common - response regulator receiver protein Caul_0096 221 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167645132 Common - major facilitator superfamily MFS_1 Caul_1167 121 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167646944 Common - UspA domain protein Caul_2982 37 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 167647901 Common - TonB-dependent receptor Caul_3941 107 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647045 Common - class II aldolase/adducin family protein Caul_3083 75 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 167644829 Common - response regulator receiver protein Caul_0863 215 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 167645075 Common - formyltetrahydrofolate deformylase Caul_1110 207 COG0788 PurU, Formyltetrahydrofolate hydrolase Nucleotide transport and metabolism 167646232 Common - conjugal transfer protein TrbD Caul_2270 11 COG5268 TrbD, Type IV secretory pathway, TrbD component Cell motility and secretion / Intracellular trafficking and secretion 167644354 Common - phospholipase D/Transphosphatidylase Caul_0382 31 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 167647094 Common - Xylan 1,4-beta-xylosidase Caul_3132 23 COG3664 XynB, Beta-xylosidase Carbohydrate transport and metabolism 167648598 Common - hypothetical protein Caul_4643 18 COG3811 COG3811, Uncharacterized protein conserved in bacteria Function unknown 167645334 Common - putative transcriptional regulator, ArsR family Caul_1369 17 COG0640 ArsR, Predicted transcriptional regulators Transcription 167645539 Common - VacJ family lipoprotein Caul_1574 94 COG2853 VacJ, Surface lipoprotein Cell envelope biogenesis, outer membrane 167648629 Common - TonB-dependent receptor Caul_4674 75 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167645465 Common - NUDIX hydrolase Caul_1500 23 None None None 167647642 Common - N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD Caul_3680 110 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 167644036 Common - acylneuraminate cytidylyltransferase Caul_0063 81 COG1861 SpsF, Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog Cell envelope biogenesis, outer membrane 167647440 Nonpathogen - hypothetical protein Caul_3478 1 None None None 167648783 Nonpathogen - hypothetical protein Caul_4828 1 None None None 167646198 Nonpathogen - helix-turn-helix domain protein Caul_2236 1 None None None 167648531 Common - NUDIX hydrolase Caul_4576 115 COG2816 NPY1, NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding DNA replication, recombination, and repair 167645592 Common - ribosomal protein S8 Caul_1628 246 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 167645059 Common - transcriptional regulator, AraC family Caul_1094 46 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 167646649 Common - transcriptional regulator, LysR family Caul_2687 114 COG0583 LysR, Transcriptional regulator Transcription 167648478 Common - pyruvate carboxyltransferase Caul_4523 146 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 167645429 Common - putative uncharacterized protein involved in ubiquinone biosynthesis Caul_1464 12 COG5031 COQ4, Uncharacterized protein involved in ubiquinone biosynthesis Coenzyme metabolism 167648442 Common - YceI family protein Caul_4487 65 COG3038 CybB, Cytochrome B561 Energy production and conversion 167645895 Common - amidohydrolase 2 Caul_1931 45 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 167647405 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase Caul_3443 174 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 167646323 Common - formyltetrahydrofolate deformylase Caul_2361 212 COG0788 PurU, Formyltetrahydrofolate hydrolase Nucleotide transport and metabolism 167647179 Common - cell division ATP-binding protein FtsE Caul_3217 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 167647545 Common - hypothetical protein Caul_3583 13 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 167648378 Common - ATP-dependent metalloprotease FtsH Caul_4423 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 167646921 Common - response regulator receiver and ANTAR domain protein Caul_2959 98 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 167645048 Common - queuosine biosynthesis protein QueD Caul_1083 79 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 167647668 Common - Serine--pyruvate transaminase Caul_3706 149 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 167645413 Common - protein of unknown function DUF470 Caul_1448 49 COG2898 COG2898, Uncharacterized conserved protein Function unknown 167647157 Common - glutathione peroxidase Caul_3195 30 None None None 167644196 Common - hypothetical protein Caul_0224 14 COG5395 COG5395, Predicted membrane protein Function unknown 167648356 Nonpathogen - hypothetical protein Caul_4401 1 None None None 167648202 Common - transposase and inactivated derivative Caul_4245 70 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 167645986 Nonpathogen - hypothetical protein Caul_2023 1 None None None 167647134 Common - hypothetical protein Caul_3172 5 None None None 167645756 Common - luciferase family protein Caul_1792 89 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 167646112 Common - hypothetical protein Caul_2149 22 COG3827 COG3827, Uncharacterized protein conserved in bacteria Function unknown 167645520 Common - amine oxidase Caul_1555 67 COG2907 COG2907, Predicted NAD/FAD-binding protein General function prediction only 167648828 Common - hypothetical protein Caul_4873 22 COG3553 COG3553, Uncharacterized protein conserved in bacteria Function unknown 167645502 Common - glycosyl transferase family 2 Caul_1537 42 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 167645901 Common - hypothetical protein Caul_1937 2 None None None 167644304 Nonpathogen - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_0332 1 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167644450 Nonpathogen - hypothetical protein Caul_0481 1 None None None 167645757 Common - isochorismatase hydrolase Caul_1793 115 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 167644962 Common - Beta-lactamase Caul_0997 65 COG2367 PenP, Beta-lactamase class A Defense mechanisms 167645084 Common - peptidase M61 domain protein Caul_1119 55 COG3975 COG3975, Predicted protease with the C-terminal PDZ domain General function prediction only 167647011 Common - 5-aminolevulinic acid synthase Caul_3049 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 167648068 Common - signal transduction histidine kinase Caul_4109 65 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 167645723 Common - Phosphoenolpyruvate carboxylase Caul_1759 116 COG2352 Ppc, Phosphoenolpyruvate carboxylase Energy production and conversion 167648569 Common - protein of unknown function DUF1080 Caul_4614 9 None None None 167644539 Common - beta-lactamase Caul_0571 80 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 167645694 Common - NUDIX hydrolase Caul_1730 111 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 167646781 Common - proton-translocating NADH-quinone oxidoreductase, chain N Caul_2819 209 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 167644387 Common - transcriptional regulator, LacI family Caul_0415 129 COG1609 PurR, Transcriptional regulators Transcription 167646371 Common - hypothetical protein Caul_2409 16 COG2850 COG2850, Uncharacterized conserved protein Function unknown 167644445 Common - transcriptional regulator, XRE family Caul_0476 27 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 167648397 Common - NusG antitermination factor Caul_4442 216 COG0250 NusG, Transcription antiterminator Transcription 167646661 Common - dTMP kinase Caul_2699 225 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 167648726 Common - RES domain protein Caul_4771 13 COG5654 COG5654, Uncharacterized conserved protein Function unknown 167646058 Common - Fimbrial assembly family protein Caul_2095 15 None None None 167644059 Nonpathogen - OmpA/MotB domain protein Caul_0086 2 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 167646792 Nonpathogen - hypothetical protein Caul_2830 1 None None None 167646996 Common - fatty acid/phospholipid synthesis protein PlsX Caul_3034 176 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 167644730 Common - AtsE Caul_0764 9 COG5622 COG5622, Protein required for attachment to host cells Cell motility and secretion 167644050 Common - L-carnitine dehydratase/bile acid-inducible protein F Caul_0077 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 167645390 Common - NHL repeat containing protein Caul_1425 76 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 167645574 Common - oxidoreductase alpha (molybdopterin) subunit Caul_1610 174 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 167646469 Common - multiple antibiotic resistance (MarC)-related protein Caul_2507 134 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 167648204 Nonpathogen - hypothetical protein Caul_4248 2 None None None 167645971 Common - integrase family protein Caul_2008 210 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 167646754 Common - protein of unknown function DUF1009 Caul_2792 45 COG3494 COG3494, Uncharacterized protein conserved in bacteria Function unknown 167647560 Common - hypothetical protein Caul_3598 8 None None None 167647677 Common - TonB-dependent receptor Caul_3715 85 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167644166 Common - ribosomal protein L21 Caul_0194 202 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 167647249 Common - integral membrane sensor signal transduction histidine kinase Caul_3287 207 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167645299 Common - transcriptional regulator, TetR family Caul_1334 64 COG1309 AcrR, Transcriptional regulator Transcription 167646709 Common - Aldehyde Dehydrogenase_ Caul_2747 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167648800 Common - short-chain dehydrogenase/reductase SDR Caul_4845 235 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 167645052 Common - transporter, hydrophobe/amphiphile efflux-1 (HAE1) family Caul_1087 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 167646047 Common - glycosyl transferase group 1 Caul_2084 97 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 167646810 Common - Endopeptidase Clp Caul_2848 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 167648700 Common - acyl-CoA dehydrogenase domain protein Caul_4745 154 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167645655 Common - protein of unknown function DUF1239 Caul_1691 19 COG5375 COG5375, Uncharacterized protein conserved in bacteria Function unknown 167645475 Common - plasmid stabilization system Caul_1510 10 COG3668 ParE, Plasmid stabilization system protein General function prediction only 167647342 Nonpathogen - hypothetical protein Caul_3380 1 None None None 167647467 Nonpathogen - hypothetical protein Caul_3505 1 None None None 167647737 Common - amidohydrolase 2 Caul_3775 29 COG3618 COG3618, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 167646964 Common - FAD linked oxidase domain protein Caul_3002 181 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 167648078 Common - hypothetical protein Caul_4119 25 None None None 167644479 Common - NAD-dependent epimerase/dehydratase Caul_0510 48 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167647009 Common - Glycine hydroxymethyltransferase Caul_3047 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 167645153 Common - phenylalanyl-tRNA synthetase, beta subunit Caul_1188 233 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 167648685 Common - putative transposase of insertion sequence ISRm2011-2, orfA protein Caul_4730 20 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646141 Common - Carbohydrate-selective porin OprB Caul_2178 15 COG3659 OprB, Carbohydrate-selective porin Cell envelope biogenesis, outer membrane 167644529 Common - cytochrome c class I Caul_0561 28 COG3474 COG3474, Cytochrome c2 Energy production and conversion 167647610 Nonpathogen - hypothetical protein Caul_3648 1 None None None 167647746 Common - hypothetical protein Caul_3784 35 COG0657 Aes, Esterase/lipase Lipid metabolism 167647447 Common - phage prohead protease, HK97 family Caul_3485 42 COG3740 COG3740, Phage head maturation protease General function prediction only 167645699 Nonpathogen - hypothetical protein Caul_1735 1 None None None 167648622 Common - beta-lactamase Caul_4667 89 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 167644687 Common - response regulator receiver protein Caul_0719 51 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 167646146 Common - HI0933 family protein Caul_2183 146 COG2081 COG2081, Predicted flavoproteins General function prediction only 167646720 Common - glutathione-dependent formaldehyde-activating GFA Caul_2758 26 COG3791 COG3791, Uncharacterized conserved protein Function unknown 167646275 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_2313 143 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167646486 Nonpathogen - hypothetical protein Caul_2524 1 None None None 167646912 Common - amino acid permease-associated region Caul_2950 65 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 167646592 Common - copper resistance B precursor Caul_2630 41 COG3667 PcoB, Uncharacterized protein involved in copper resistance Inorganic ion transport and metabolism 167646540 Common - protein of unknown function DUF583 Caul_2578 28 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 167645784 Nonpathogen - conserved hypothetical protein; putative secreted protein Caul_1820 8 None None None 167646842 Nonpathogen - hypothetical protein Caul_2880 1 None None None 167647916 Common - transcriptional regulator, GntR family Caul_3956 22 COG1802 GntR, Transcriptional regulators Transcription 167645432 Nonpathogen - hypothetical protein Caul_1467 1 None None None 167648671 Common - hypothetical protein Caul_4716 10 None None None 167644499 Common - NADH:flavin oxidoreductase/NADH oxidase Caul_0530 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 167647296 Common - thioesterase superfamily protein Caul_3334 20 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 167645140 Nonpathogen - hypothetical protein Caul_1175 1 None None None 167647511 Common - multi-sensor hybrid histidine kinase Caul_3549 223 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 167648320 Nonpathogen - hypothetical protein Caul_4365 1 None None None 167645147 Common - hypothetical protein Caul_1182 22 COG5400 COG5400, Uncharacterized protein conserved in bacteria Function unknown 167648430 Common - phosphomethylpyrimidine kinase Caul_4475 218 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 167645256 Common - glycoside hydrolase family 35 Caul_1291 7 COG1874 LacA, Beta-galactosidase Carbohydrate transport and metabolism 167644470 Common - IgiC, putative Caul_0501 18 COG3473 COG3473, Maleate cis-trans isomerase Secondary metabolites biosynthesis, transport, and catabolism 167646605 Nonpathogen - hypothetical protein Caul_2643 7 None None None 167646621 Common - Acyl-CoA dehydrogenase type 2 domain Caul_2659 139 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167645327 Common - transcriptional regulator, LuxR family Caul_1362 17 COG2771 CsgD, DNA-binding HTH domain-containing proteins Transcription 167646394 Common - short-chain dehydrogenase/reductase SDR Caul_2432 219 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 167646295 Nonpathogen - hypothetical protein Caul_2333 1 None None None 167647020 Common - NUDIX hydrolase Caul_3058 39 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 167648542 Common - Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family Caul_4587 120 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 167648252 Nonpathogen - hypothetical protein Caul_4297 1 None None None 167645883 Common - major facilitator superfamily MFS_1 Caul_1919 95 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 167647589 Common - hypothetical protein Caul_3627 23 None None None 167644702 Common - PilT protein domain protein Caul_0736 17 COG3742 COG3742, Uncharacterized protein conserved in bacteria Function unknown 167646315 Common - acyltransferase 3 Caul_2353 67 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 167644572 Nonpathogen - hypothetical protein Caul_0604 2 None None None 167644313 Common - integrase family protein Caul_0341 101 COG0582 XerC, Integrase DNA replication, recombination, and repair 167646707 Common - protein of unknown function DUF1006 Caul_2745 59 COG3214 COG3214, Uncharacterized protein conserved in bacteria Function unknown 167645295 Common - Mammalian cell entry related domain protein Caul_1330 101 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 167645226 Common - ABC transporter related Caul_1261 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 167648143 Common - purine nucleoside permease Caul_4184 11 COG5042 NUP, Purine nucleoside permease Nucleotide transport and metabolism 167648912 Common - ABC transporter related Caul_4957 249 COG1137 YhbG, ABC-type (unclassified) transport system, ATPase component General function prediction only 167647822 Common - cyclic nucleotide-binding protein Caul_3861 62 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 167648879 Common - transferase hexapeptide repeat containing protein Caul_4924 130 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 167648965 Nonpathogen - hypothetical protein Caul_5010 1 None None None 167647704 Common - transferase family protein Caul_3742 190 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 167644725 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_0759 80 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167644594 Common - L-carnitine dehydratase/bile acid-inducible protein F Caul_0626 115 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 167646006 Common - TIM-barrel protein, yjbN family Caul_2043 207 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 167646816 Common - Erythromycin esterase Caul_2854 79 COG2312 COG2312, Erythromycin esterase homolog General function prediction only 167644646 Nonpathogen - transcriptional regulator, TetR family, putative Caul_0678 8 None None None 167648422 Common - D-3-phosphoglycerate dehydrogenase Caul_4467 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 167647630 Common - PAS/PAC sensor hybrid histidine kinase Caul_3668 195 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167647478 Nonpathogen - hypothetical protein Caul_3516 1 None None None 167647568 Common - (2Fe-2S)-binding domain protein Caul_3606 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 167648953 Common - leucine rich repeat variant Caul_4998 4 None None None 167645030 Common - peptidase M20 Caul_1065 141 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 167647972 Common - AMP-dependent synthetase and ligase Caul_4012 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167644285 Common - Alpha-galactosidase Caul_0313 18 COG3345 GalA, Alpha-galactosidase Carbohydrate transport and metabolism 167645995 Common - P-type conjugative transfer protein TrbL Caul_2032 29 COG3846 TrbL, Type IV secretory pathway, TrbL components Intracellular trafficking and secretion 167646524 Common - hypothetical protein Caul_2562 28 COG4765 COG4765, Uncharacterized protein conserved in bacteria Function unknown 167647476 Common - RNA-binding S4 domain protein Caul_3514 224 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 167648747 Common - glycoside hydrolase family 16 Caul_4792 74 COG2273 SKN1, Beta-glucanase/Beta-glucan synthetase Carbohydrate transport and metabolism 167645005 Common - mannanase, putative Caul_1040 13 COG3934 COG3934, Endo-beta-mannanase Carbohydrate transport and metabolism 167647225 Common - response regulator receiver protein Caul_3263 196 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167647751 Common - transcriptional regulator, XRE family Caul_3790 38 COG1396 HipB, Predicted transcriptional regulators Transcription 167645906 Common - carbonate dehydratase Caul_1942 30 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 167645025 Common - Glutathione S-transferase domain Caul_1060 85 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167647538 Common - acyl-CoA dehydrogenase domain protein Caul_3576 161 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167647813 Common - 3-carboxy-cis,cis-muconate cycloisomerase Caul_3852 155 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 167644399 Common - Xylose isomerase domain protein TIM barrel Caul_0427 66 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 167646443 Common - Peptidase M15A Caul_2481 16 COG3108 COG3108, Uncharacterized protein conserved in bacteria Function unknown 167645039 Common - signal transduction histidine kinase Caul_1074 106 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 167647508 Common - UDP-N-acetylglucosamine pyrophosphorylase Caul_3546 229 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 167646848 Common - flagellin domain protein Caul_2886 115 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 167646696 Common - Adenosylcobinamide kinase Caul_2734 124 COG2087 CobU, Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase Coenzyme metabolism 167645970 Common - integrase family protein Caul_2007 119 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 167647877 Common - protein of unknown function DUF559 Caul_3917 44 COG2852 COG2852, Uncharacterized protein conserved in bacteria Function unknown 167645557 Common - peptidase M24 Caul_1592 182 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 167647482 Common - protein of unknown function DUF1214 Caul_3520 42 COG5361 COG5361, Uncharacterized conserved protein Function unknown 167645570 Common - RNA methyltransferase, TrmH family, group 3 Caul_1606 213 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 167645182 Nonpathogen - hypothetical protein Caul_1217 2 None None None 167647531 Common - DNA-3-methyladenine glycosylase Caul_3569 84 COG2094 Mpg, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 167647166 Common - transcriptional regulator, TetR family Caul_3204 64 COG1309 AcrR, Transcriptional regulator Transcription 167644106 Common - putative phage repressor Caul_0133 24 COG2932 COG2932, Predicted transcriptional regulator Transcription 167647689 Nonpathogen - HfaB protein Caul_3727 6 COG1462 CsgG, Uncharacterized protein involved in formation of curli polymers Cell envelope biogenesis, outer membrane 167644376 Nonpathogen - transcriptional regulator, XRE family Caul_0404 1 COG1396 HipB, Predicted transcriptional regulators Transcription 167644950 Common - plasmid stabilization system Caul_0985 26 COG3668 ParE, Plasmid stabilization system protein General function prediction only 167647471 Nonpathogen - hypothetical protein Caul_3509 1 None None None 167644294 Common - hypothetical protein Caul_0322 5 None None None 167645689 Common - Endothelin-converting enzyme 1 Caul_1725 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 167644797 Common - hypothetical protein Caul_0831 22 None None None 167647603 Nonpathogen - hypothetical protein Caul_3641 1 None None None 167645606 Common - ABC transporter related Caul_1642 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 167646928 Nonpathogen - hypothetical protein Caul_2966 1 None None None 167646957 Common - TonB-dependent receptor Caul_2995 35 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167644424 Common - Integrase catalytic region Caul_0452 146 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 167648188 Common - short-chain dehydrogenase/reductase SDR Caul_4231 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167644132 Common - hypothetical protein Caul_0160 51 COG3607 COG3607, Predicted lactoylglutathione lyase General function prediction only 167645666 Nonpathogen - articulin, putative Caul_1702 1 COG4907 COG4907, Predicted membrane protein Function unknown 167644959 Common - transcriptional regulator, LysR family Caul_0994 162 COG0583 LysR, Transcriptional regulator Transcription 167646392 Common - AMP-dependent synthetase and ligase Caul_2430 210 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 167647832 Common - carbonic anhydrase Caul_3871 117 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 167644099 Common - acetyl-CoA acetyltransferase Caul_0126 174 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167647889 Common - transcriptional regulator, TetR family Caul_3929 110 COG1309 AcrR, Transcriptional regulator Transcription 167647899 Nonpathogen - hypothetical protein Caul_3939 1 None None None 167646167 Common - succinylarginine dihydrolase Caul_2204 34 COG3724 AstB, Succinylarginine dihydrolase Amino acid transport and metabolism 167644902 Common - Alpha-N-arabinofuranosidase Caul_0936 41 COG3507 XynB, Beta-xylosidase Carbohydrate transport and metabolism 167648302 Common - hypothetical protein Caul_4347 19 COG3671 COG3671, Predicted membrane protein Function unknown 167647866 Common - Excinuclease ABC C subunit domain protein Caul_3906 32 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 167644974 Common - flagellar hook capping protein Caul_1009 41 COG1843 FlgD, Flagellar hook capping protein Cell motility and secretion 167646834 Common - superoxide dismutase copper/zinc binding Caul_2872 67 COG2032 SodC, Cu/Zn superoxide dismutase Inorganic ion transport and metabolism 167647335 Common - protein of unknown function DUF307 Caul_3373 42 COG3304 COG3304, Predicted membrane protein Function unknown 167645513 Common - transcriptional regulator, IclR family Caul_1548 58 COG1414 IclR, Transcriptional regulator Transcription 167646421 Nonpathogen - response regulator receiver protein Caul_2459 9 COG4566 TtrR, Response regulator Signal transduction mechanisms 167648185 Common - transposase IS3/IS911 family protein Caul_4228 44 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646981 Nonpathogen - hypothetical protein Caul_3019 1 None None None 167648980 Common - methyltransferase GidB Caul_5025 74 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 167647892 Common - transcriptional regulator, TetR family Caul_3932 48 COG1309 AcrR, Transcriptional regulator Transcription 167644121 Common - amine oxidase Caul_0148 28 COG1231 COG1231, Monoamine oxidase Amino acid transport and metabolism 167645604 Common - methyl-accepting chemotaxis sensory transducer Caul_1640 145 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 167648633 Common - Endothelin-converting enzyme 1 Caul_4678 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 167646906 Common - short-chain dehydrogenase/reductase SDR Caul_2944 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 167647882 Common - TonB-dependent receptor Caul_3922 113 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 167644788 Nonpathogen - hypothetical protein Caul_0822 1 None None None 167648241 Common - carbamoyl-phosphate synthase, large subunit Caul_4285 233 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 167646051 Common - transcriptional regulator, LuxR family Caul_2088 83 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 167644873 Common - OsmC family protein Caul_0907 41 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 167647307 Common - HflC protein Caul_3345 188 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 167648839 Common - Serralysin Caul_4884 93 COG2931 COG2931, RTX toxins and related Ca2+-binding proteins Secondary metabolites biosynthesis, transport, and catabolism 167648124 Common - type I secretion system ATPase Caul_4165 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 167647988 Common - hypothetical protein Caul_4028 5 None None None 167645935 Common - glycerophosphoryl diester phosphodiesterase Caul_1971 64 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 167646773 Common - lipoprotein releasing system, transmembrane protein, LolC/E family Caul_2811 195 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 167647778 Common - putative plasmid replication protein A Caul_3817 32 COG5534 COG5534, Plasmid replication initiator protein DNA replication, recombination, and repair 167646974 Common - Hemolysin-type calcium-binding region Caul_3012 73 None None None 167648516 Common - Cupin 2 conserved barrel domain protein Caul_4561 26 COG3837 COG3837, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 167644393 Nonpathogen - hypothetical protein Caul_0421 2 None None None 167644601 Common - ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD Caul_0633 136 COG4988 CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 167647398 Common - Glutathione S-transferase domain Caul_3436 56 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167645585 Common - ribosomal protein L16 Caul_1621 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 167648707 Common - acetyl-CoA acetyltransferase Caul_4752 167 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167647976 Common - TonB-dependent receptor Caul_4016 91 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 167646341 Nonpathogen - hypothetical protein Caul_2379 4 None None None 167645746 Common - protein of unknown function DUF882 Caul_1782 63 COG3108 COG3108, Uncharacterized protein conserved in bacteria Function unknown 167645380 Common - protein of unknown function DUF47 Caul_1415 65 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 167644408 Common - major facilitator superfamily MFS_1 Caul_0436 5 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167644331 Common - 4-hydroxybenzoate polyprenyl transferase Caul_0359 175 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 167648061 Nonpathogen - transcriptional regulator, TetR family Caul_4102 8 COG1309 AcrR, Transcriptional regulator Transcription 167647380 Common - peptidase S9B dipeptidylpeptidase IV domain protein Caul_3418 101 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 167648989 Common - alanine racemase domain protein Caul_5034 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 167645305 Common - putative transcriptional regulator Caul_1340 7 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 167647066 Common - hypothetical protein Caul_3104 25 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 167644597 Common - transcriptional regulator, Crp/Fnr family Caul_0629 160 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 167646312 Common - hypothetical protein Caul_2350 6 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 167644181 Common - YhhN family protein Caul_0209 7 COG3714 COG3714, Predicted membrane protein Function unknown 167646136 Nonpathogen - hypothetical protein Caul_2173 1 None None None 167647219 Common - hypothetical protein Caul_3257 20 COG3644 COG3644, Uncharacterized protein conserved in bacteria Function unknown 167647669 Common - urate catabolism protein Caul_3707 65 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 167644781 Nonpathogen - DegT/DnrJ/EryC1/StrS aminotransferase Caul_0815 6 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 167645825 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_1861 111 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167646111 Common - type I secretion outer membrane protein, TolC family Caul_2148 130 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 167644119 Common - alpha/beta hydrolase fold Caul_0146 165 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167644919 Common - PTSINtr with GAF domain, PtsP Caul_0954 235 COG3605 PtsP, Signal transduction protein containing GAF and PtsI domains Signal transduction mechanisms 167647857 Common - Propeptide PepSY amd peptidase M4 Caul_3897 8 COG3212 COG3212, Predicted membrane protein Function unknown 167644932 Common - transcriptional regulator, LacI family Caul_0967 127 COG1609 PurR, Transcriptional regulators Transcription 167648938 Nonpathogen - heme exporter protein CcmD Caul_4983 1 None None None 167643989 Nonpathogen - hypothetical protein Caul_0016 1 None None None 167647211 Common - short-chain dehydrogenase/reductase SDR Caul_3249 230 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 167644822 Common - oxidoreductase FAD/NAD(P)-binding domain protein Caul_0856 136 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 167647183 Common - Aspartyl/Asparaginyl beta-hydroxylase Caul_3221 13 None None None 167647282 Common - GCN5-related N-acetyltransferase Caul_3320 49 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 167647707 Common - aldo/keto reductase Caul_3745 199 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 167646873 Nonpathogen - hypothetical protein Caul_2911 1 None None None 167645383 Common - FAD dependent oxidoreductase Caul_1418 31 COG1232 HemY, Protoporphyrinogen oxidase Coenzyme metabolism 167644188 Common - 3-isopropylmalate dehydratase, large subunit Caul_0216 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 167645942 Common - Methyltransferase type 11 Caul_1979 197 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 167644734 Nonpathogen - hypothetical protein Caul_0768 1 None None None 167645682 Nonpathogen - hypothetical protein Caul_1718 7 None None None 167648272 Nonpathogen - hypothetical protein Caul_4317 9 COG4731 COG4731, Uncharacterized protein conserved in bacteria Function unknown 167645309 Nonpathogen - hypothetical protein Caul_1344 6 None None None 167647793 Common - hypothetical protein Caul_3832 10 None None None 167644338 Common - NAD-dependent epimerase/dehydratase Caul_0366 18 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167644201 Common - succinyl-CoA synthetase, beta subunit Caul_0229 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 167648439 Nonpathogen - hypothetical protein Caul_4484 2 None None None 167646160 Common - protein of unknown function DUF403 Caul_2197 84 COG2307 COG2307, Uncharacterized protein conserved in bacteria Function unknown 167645281 Common - beta-lactamase domain protein Caul_1316 167 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 167644218 Common - pentapeptide repeat protein Caul_0246 87 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 167647636 Nonpathogen - hypothetical protein Caul_3674 1 COG5462 COG5462, Predicted secreted (periplasmic) protein Function unknown 167644969 Nonpathogen - hypothetical protein Caul_1004 1 None None None 167648741 Common - protein of unknown function DUF405 Caul_4786 50 COG2311 COG2311, Predicted membrane protein Function unknown 167644209 Common - sulfatase Caul_0237 45 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 167644939 Common - OsmC family protein Caul_0974 45 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 167648813 Common - transcriptional regulator, MarR family Caul_4858 60 COG1846 MarR, Transcriptional regulators Transcription 167644032 Common - molybdenum cofactor biosynthesis protein B Caul_0059 168 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 167644540 Common - TonB-dependent receptor Caul_0572 115 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167644236 Common - protein of unknown function DUF21 Caul_0264 219 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 167646440 Common - Thioredoxin domain Caul_2478 227 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 167646453 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_2491 113 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167645078 Common - hypothetical protein Caul_1113 23 COG5266 CbiK, ABC-type Co2+ transport system, periplasmic component Inorganic ion transport and metabolism 167644665 Common - hypothetical protein Caul_0697 13 None None None 167648455 Common - protein of unknown function DUF983 Caul_4500 25 COG5349 COG5349, Uncharacterized protein conserved in bacteria Function unknown 167646250 Nonpathogen - hypothetical protein Caul_2288 2 COG3019 COG3019, Predicted metal-binding protein General function prediction only 167648461 Common - cytochrome c oxidase, subunit II Caul_4506 146 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 167647763 Common - hypothetical protein Caul_3802 5 None None None 167645580 Common - Ribosomal protein L25/L23 Caul_1616 173 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 167645594 Common - ribosomal protein L18 Caul_1630 215 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 167644592 Common - transcriptional regulator, AraC family Caul_0624 135 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 167647305 Common - protein of unknown function DUF59 Caul_3343 231 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 167646154 Common - queuine tRNA-ribosyltransferase Caul_2191 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 167646310 Common - protein of unknown function DUF411 Caul_2348 64 COG3019 COG3019, Predicted metal-binding protein General function prediction only 167644992 Common - peptidase M23B Caul_1027 188 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 167646008 Nonpathogen - hypothetical protein Caul_2045 1 None None None 167648755 Nonpathogen - hypothetical protein Caul_4800 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 167646246 Common - outer membrane efflux protein Caul_2284 40 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 167646712 Common - cyclase/dehydrase Caul_2750 99 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 167648946 Common - protein of unknown function DUF1223 Caul_4991 33 COG5429 COG5429, Uncharacterized secreted protein Function unknown 167644029 Common - molybdenum cofactor biosynthesis protein A Caul_0056 197 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 167648160 Common - para-aminobenzoate synthase component I Caul_4201 221 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 167647268 Common - RND efflux system, outer membrane lipoprotein, NodT family Caul_3306 108 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 167645115 Nonpathogen - Conjugal transfer TraD family protein Caul_1150 10 None None None 167644357 Common - homoserine O-acetyltransferase Caul_0385 133 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 167648844 Common - 16S rRNA processing protein RimM Caul_4889 121 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 167646628 Common - Glutathione S-transferase domain Caul_2666 98 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167647959 Common - protein of unknown function DUF427 Caul_3999 47 COG2343 COG2343, Uncharacterized protein conserved in bacteria Function unknown 167646598 Common - transglutaminase domain protein Caul_2636 81 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 167648603 Common - transcriptional coactivator/pterin dehydratase Caul_4648 82 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 167648136 Common - transcriptional regulator, XRE family Caul_4177 9 COG1476 COG1476, Predicted transcriptional regulators Transcription 167648122 Nonpathogen - hypothetical protein Caul_4163 1 None None None 167646334 Common - Gamma-glutamyltransferase Caul_2372 147 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 167648510 Common - signal transduction histidine kinase Caul_4555 144 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 167646365 Common - protein of unknown function DUF303 acetylesterase putative Caul_2403 15 None None None 167647241 Common - putative lipoprotein Caul_3279 3 None None None 167648227 Nonpathogen - hypothetical protein Caul_4271 1 None None None 167643982 Common - UTP-GlnB uridylyltransferase, GlnD Caul_0009 123 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 167646184 Nonpathogen - hypothetical protein Caul_2221 1 None None None 167645797 Common - hypothetical protein Caul_1833 8 None None None 167644627 Common - integral membrane sensor hybrid histidine kinase Caul_0659 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167645692 Common - (p)ppGpp synthetase I, SpoT/RelA Caul_1728 206 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 167645397 Common - flagellar basal body rod protein Caul_1432 125 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 167643976 Common - Peptidase M1 membrane alanine aminopeptidase Caul_0003 162 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 167648687 Common - small multidrug resistance protein Caul_4732 108 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 167644323 Common - Phosphoribosyl-AMP cyclohydrolase Caul_0351 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 167646138 Common - glycyl-tRNA synthetase, beta subunit Caul_2175 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 167646281 Nonpathogen - hypothetical protein Caul_2319 1 None None None 167648086 Nonpathogen - hypothetical protein Caul_4127 1 None None None 167648868 Common - mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase Caul_4913 161 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 167646056 Nonpathogen - hypothetical protein Caul_2093 1 None None None 167647357 Common - heat shock protein DnaJ domain protein Caul_3395 32 COG1076 DjlA, DnaJ-domain-containing proteins 1 Posttranslational modification, protein turnover, chaperones 167645338 Common - ribosome small subunit-dependent GTPase A Caul_1373 163 COG1162 COG1162, Predicted GTPases General function prediction only 167645955 Common - transcriptional regulator, XRE family Caul_1992 5 COG1476 COG1476, Predicted transcriptional regulators Transcription 167644841 Common - 6-phosphogluconate dehydrogenase NAD-binding Caul_0875 161 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 167644834 Common - major facilitator superfamily MFS_1 Caul_0868 66 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167647279 Common - exodeoxyribonuclease VII, small subunit Caul_3317 88 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 167648466 Common - cation efflux protein Caul_4511 58 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 167647188 Common - plasmid maintenance system killer Caul_3226 58 COG3549 HigB, Plasmid maintenance system killer protein General function prediction only 167647452 Common - phage protein, HK97 gp10 family Caul_3490 2 None None None 167648733 Nonpathogen - conserved hypothetical signal peptide protein Caul_4778 6 None None None 167649011 Common - succinate CoA transferase Caul_5056 95 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 167647365 Nonpathogen - hypothetical protein Caul_3403 1 None None None 167647192 Nonpathogen - putative signal transduction protein with EFhand domain Caul_3230 2 COG5126 FRQ1, Ca2+-binding protein (EF-Hand superfamily) Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only 167645815 Common - SapC family protein Caul_1851 20 None None None 167645064 Common - Tail Collar domain protein Caul_1099 38 COG4675 MdpB, Microcystin-dependent protein Function unknown 167646585 Common - hypothetical protein Caul_2623 8 None None None 167647352 Common - short-chain dehydrogenase/reductase SDR Caul_3390 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167644705 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Caul_0739 186 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 167647287 Nonpathogen - hypothetical protein Caul_3325 1 None None None 167647952 Common - flavodoxin/nitric oxide synthase Caul_3992 87 COG0369 CysJ, Sulfite reductase, alpha subunit (flavoprotein) Inorganic ion transport and metabolism 167647559 Common - transcriptional regulator, MarR family Caul_3597 107 COG1846 MarR, Transcriptional regulators Transcription 167644315 Common - beta-lactamase domain protein Caul_0343 77 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 167648673 Common - nicotinate (nicotinamide) nucleotide adenylyltransferase Caul_4718 180 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 167644799 Nonpathogen - type IV pilus assembly PilZ Caul_0833 1 None None None 167648763 Common - membrane bound O-acyl transferase MBOAT family protein Caul_4808 86 COG1696 DltB, Predicted membrane protein involved in D-alanine export Cell envelope biogenesis, outer membrane 167646293 Common - transcriptional regulator, MerR family Caul_2331 103 COG0789 SoxR, Predicted transcriptional regulators Transcription 167645244 Common - hypothetical protein Caul_1279 118 COG2855 COG2855, Predicted membrane protein Function unknown 167649014 Common - protein of unknown function DUF1058 Caul_5059 45 COG3807 COG3807, Uncharacterized protein conserved in bacteria Function unknown 167646027 Common - tryptophan halogenase Caul_2064 17 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 167644503 Common - alpha/beta hydrolase fold Caul_0534 125 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167645708 Common - DNA topoisomerase IV, A subunit Caul_1744 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 167647058 Common - Exonuclease RNase T and DNA polymerase III Caul_3096 98 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 167646178 Common - Fmu (Sun) domain protein Caul_2215 206 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 167648211 Common - hypothetical protein Caul_4255 15 None None None 167646741 Common - beta-lactamase Caul_2779 132 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 167646264 Common - iron permease FTR1 Caul_2302 67 COG0672 FTR1, High-affinity Fe2+/Pb2+ permease Inorganic ion transport and metabolism 167646063 Common - hypothetical protein Caul_2100 16 None None None 167644159 Nonpathogen - hypothetical protein Caul_0187 2 None None None 167644893 Nonpathogen - hypothetical protein Caul_0927 5 None None None 167647884 Nonpathogen - hypothetical protein Caul_3924 1 None None None 167646099 Common - sugar transporter Caul_2136 139 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167646678 Common - DegT/DnrJ/EryC1/StrS aminotransferase Caul_2716 196 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 167644860 Common - hypothetical protein Caul_0894 7 None None None 167648871 Common - Mannose-6-phosphate isomerase Caul_4916 52 COG2942 COG2942, N-acyl-D-glucosamine 2-epimerase Carbohydrate transport and metabolism 167646652 Common - RND efflux system, outer membrane lipoprotein, NodT family Caul_2690 105 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 167647964 Common - short-chain dehydrogenase/reductase SDR Caul_4004 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167646118 Common - hemolysin A Caul_2155 132 COG1189 COG1189, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 167647740 Common - Aldehyde Dehydrogenase_ Caul_3778 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167648113 Nonpathogen - hypothetical protein Caul_4154 1 None None None 167646020 Nonpathogen - hypothetical protein Caul_2057 1 None None None 167647387 Common - hypothetical protein Caul_3425 10 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 167645967 Common - Methyltransferase type 11 Caul_2004 26 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 167647120 Common - glycoside hydrolase family 24 Caul_3158 38 COG3772 COG3772, Phage-related lysozyme (muraminidase) General function prediction only 167648841 Nonpathogen - Cyanovirin-N domain protein Caul_4886 1 None None None 167645394 Common - flagellar L-ring protein Caul_1429 101 COG2063 FlgH, Flagellar basal body L-ring protein Cell motility and secretion 167646418 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Caul_2456 11 COG3871 COG3871, Uncharacterized stress protein (general stress protein 26) General function prediction only 167644283 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Caul_0311 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 167647722 Common - TonB-dependent receptor Caul_3760 59 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167644257 Nonpathogen - CheU protein Caul_0285 1 None None None 167648694 Nonpathogen - Methyltransferase type 11 Caul_4739 6 None None None 167645861 Common - acetyl-CoA acetyltransferase Caul_1897 167 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167647018 Common - hypothetical protein Caul_3056 12 COG4731 COG4731, Uncharacterized protein conserved in bacteria Function unknown 167646587 Nonpathogen - hypothetical protein Caul_2625 4 COG5649 COG5649, Uncharacterized conserved protein Function unknown 167644803 Nonpathogen - hypothetical protein Caul_0837 4 COG5450 COG5450, Transcription regulator of the Arc/MetJ class Transcription 167646036 Common - TonB-dependent receptor Caul_2073 60 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 167646833 Common - DNA gyrase, A subunit Caul_2871 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 167647270 Common - acriflavin resistance protein Caul_3308 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 167644852 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_0886 16 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167644754 Common - histidine triad (HIT) protein Caul_0788 224 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 167645023 Nonpathogen - hypothetical protein Caul_1058 1 None None None 167648388 Nonpathogen - Rv0623 family protein transcription factor Caul_4433 1 COG4423 COG4423, Uncharacterized protein conserved in bacteria Function unknown 167648052 Common - outer membrane efflux protein Caul_4093 44 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 167648508 Common - phosphate-selective porin O and P Caul_4553 24 COG3746 OprP, Phosphate-selective porin Inorganic ion transport and metabolism 167646390 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_2428 26 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167645796 Common - glycoside hydrolase family 3 domain protein Caul_1832 135 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 167646388 Common - TonB-dependent receptor plug Caul_2426 52 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647243 Common - anti-FecI sigma factor, FecR Caul_3281 47 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 167644989 Common - hypothetical protein Caul_1024 47 COG4188 COG4188, Predicted dienelactone hydrolase General function prediction only 167645210 Common - peptide chain release factor 3 Caul_1245 248 COG4108 PrfC, Peptide chain release factor RF-3 Translation, ribosomal structure and biogenesis 167648807 Common - double-strand break repair protein AddB Caul_4852 48 COG3893 COG3893, Inactivated superfamily I helicase DNA replication, recombination, and repair 167644457 Common - aldo/keto reductase Caul_0488 197 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 167647255 Common - citrate/H+ symporter, CitMHS family Caul_3293 31 COG2851 CitM, H+/citrate symporter Energy production and conversion 167648373 Common - hypothetical protein Caul_4418 5 COG5451 COG5451, Predicted secreted protein Function unknown 167648348 Common - addiction module antidote Caul_4393 22 None None None 167648102 Common - hypothetical protein Caul_4143 19 COG4246 COG4246, Uncharacterized protein conserved in bacteria Function unknown 167647312 Common - CinA domain protein Caul_3350 171 COG1546 CinA, Uncharacterized protein (competence- and mitomycin-induced) General function prediction only 167647522 Common - transposase and inactivated derivatives-like protein Caul_3560 46 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 167647228 Common - hypothetical protein Caul_3266 53 COG3749 COG3749, Uncharacterized protein conserved in bacteria Function unknown 167648057 Common - hypothetical protein Caul_4098 2 None None None 167647983 Common - YceI family protein Caul_4023 115 COG2353 COG2353, Uncharacterized conserved protein Function unknown 167645565 Common - alpha/beta hydrolase fold Caul_1601 111 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167645261 Common - N-formylglutamate amidohydrolase Caul_1296 57 COG3741 HutG, N-formylglutamate amidohydrolase Amino acid transport and metabolism 167647004 Nonpathogen - hypothetical protein Caul_3042 1 None None None 167647111 Common - pantoate--beta-alanine ligase Caul_3149 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 167648407 Common - ABC transporter related Caul_4452 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 167648222 Nonpathogen - hypothetical protein Caul_4266 1 COG4907 COG4907, Predicted membrane protein Function unknown 167647038 Common - cytochrome c class I Caul_3076 57 COG3474 COG3474, Cytochrome c2 Energy production and conversion 167646015 Common - hypothetical protein Caul_2052 112 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 167648341 Common - glycine cleavage system H protein Caul_4386 185 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 167645106 Common - methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor Caul_1141 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 167646257 Common - efflux transporter, RND family, MFP subunit Caul_2295 99 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 167645360 Common - transcriptional regulator, AraC family Caul_1395 120 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 167648541 Common - Tetratricopeptide TPR_2 repeat protein Caul_4586 15 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 167648414 Common - polysaccharide biosynthesis protein CapD Caul_4459 145 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167644696 Common - aldo/keto reductase Caul_0728 199 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 167646220 Common - hypothetical protein Caul_2258 3 None None None 167645218 Nonpathogen - hypothetical protein Caul_1253 2 None None None 167645018 Common - transcriptional regulator, TetR family Caul_1053 5 COG1309 AcrR, Transcriptional regulator Transcription 167646373 Common - putative esterase Caul_2411 61 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 167645176 Common - pentapeptide repeat protein Caul_1211 94 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 167643998 Common - apolipoprotein N-acyltransferase Caul_0025 152 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 167644534 Common - Integrase catalytic region Caul_0566 75 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 167644436 Nonpathogen - hypothetical protein Caul_0467 2 None None None 167644045 Common - fumarylacetoacetate (FAA) hydrolase Caul_0072 179 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 167648925 Common - GSCFA domain protein Caul_4970 33 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 167646438 Common - transcriptional regulator, ArsR family Caul_2476 99 COG0640 ArsR, Predicted transcriptional regulators Transcription 167645804 Common - tryptophan halogenase Caul_1840 16 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 167645185 Common - histidinol-phosphate phosphatase Caul_1220 187 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 167647059 Common - DNA ligase, NAD-dependent Caul_3097 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 167647095 Common - oxidoreductase domain protein Caul_3133 66 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 167648278 Common - cell wall hydrolase SleB Caul_4323 46 COG3773 SleB, Cell wall hydrolyses involved in spore germination Cell envelope biogenesis, outer membrane 167644297 Nonpathogen - hypothetical protein Caul_0325 2 None None None 167644365 Common - hypothetical protein Caul_0393 5 None None None 167647406 Common - phosphoribosylformylglycinamidine synthase, purS Caul_3444 101 COG1828 PurS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component Nucleotide transport and metabolism 167646826 Nonpathogen - Cupin 2 conserved barrel domain protein Caul_2864 1 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 167648333 Common - H+transporting two-sector ATPase C subunit Caul_4378 22 None None None 167645646 Common - hypothetical protein Caul_1682 16 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 167646229 Nonpathogen - phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthase-like protein Caul_2267 2 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 167644252 Common - CheW protein Caul_0280 133 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 167648884 Common - Tetratricopeptide TPR_2 repeat protein Caul_4929 30 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 167644867 Common - rpsU-divergently transcribed protein Caul_0901 18 COG5590 COG5590, Uncharacterized conserved protein Function unknown 167646619 Common - binding-protein-dependent transport systems inner membrane component Caul_2657 197 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 167646512 Nonpathogen - hypothetical protein Caul_2550 1 None None None 167647118 Common - Trans-aconitate 2-methyltransferase Caul_3156 81 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 167644654 Common - short-chain dehydrogenase/reductase SDR Caul_0686 85 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167644317 Common - pseudouridine synthase, RluA family Caul_0345 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 167645506 Common - Alpha-L-fucosidase Caul_1541 31 COG3669 COG3669, Alpha-L-fucosidase Carbohydrate transport and metabolism 167647688 Nonpathogen - HfaA protein Caul_3726 2 None None None 167648551 Common - hypothetical protein Caul_4596 31 None None None 167646894 Common - hypothetical protein Caul_2932 6 None None None 167647562 Common - transposase IS3/IS911 family protein Caul_3600 44 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 167645787 Common - conserved hypothetical phage tail protein Caul_1823 27 None None None 167645348 Common - flagellar biosynthetic protein FliR Caul_1383 125 COG1684 FliR, Flagellar biosynthesis pathway, component FliR Cell motility and secretion / Intracellular trafficking and secretion 167647161 Common - Peptidase M1 membrane alanine aminopeptidase Caul_3199 138 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 167644982 Common - flagellar biosynthesis protein FlhA Caul_1017 127 COG1298 FlhA, Flagellar biosynthesis pathway, component FlhA Cell motility and secretion / Intracellular trafficking and secretion 167647029 Common - TonB-dependent receptor Caul_3067 119 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167644923 Common - SSS sodium solute transporter superfamily Caul_0958 174 COG4147 DhlC, Predicted symporter General function prediction only 167648099 Nonpathogen - hypothetical protein Caul_4140 4 None None None 167644786 Common - pyruvate ferredoxin/flavodoxin oxidoreductase Caul_0820 86 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 167644001 Common - tRNA (guanine-N(7)-)-methyltransferase Caul_0028 173 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 167644124 Common - glycoside hydrolase family 3 domain protein Caul_0152 110 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 167648593 Nonpathogen - hypothetical protein Caul_4638 4 None None None 167644714 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_0748 59 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167646616 Common - Integrase catalytic region Caul_2654 24 None None None 167648588 Common - DegT/DnrJ/EryC1/StrS aminotransferase Caul_4633 192 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 167648858 Common - MscS Mechanosensitive ion channel Caul_4903 157 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 167645727 Common - penicillin-binding protein 2 Caul_1763 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 167645671 Common - Polyprenyl synthetase Caul_1707 239 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 167647526 Common - protein of unknown function DUF140 Caul_3564 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 167647804 Nonpathogen - hypothetical protein Caul_3843 3 None None None 167648594 Common - RNA-binding S4 domain protein Caul_4639 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 167645168 Common - Chromosomal replication initiator DnaA domain Caul_1203 12 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 167645456 Nonpathogen - hypothetical protein Caul_1491 3 None None None 167648972 Common - Ferrochelatase Caul_5017 176 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 167644801 Common - hypothetical protein Caul_0835 21 COG4323 COG4323, Predicted membrane protein Function unknown 167647052 Common - iron compound ABC transporter, periplasmic substrate-binding protein Caul_3090 23 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 167647991 Common - transcriptional regulator, LysR family Caul_4031 102 COG0583 LysR, Transcriptional regulator Transcription 167647320 Nonpathogen - hypothetical protein Caul_3358 1 None None None 167648821 Common - MiaB-like tRNA modifying enzyme Caul_4866 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 167647208 Common - Vanillate monooxygenase Caul_3246 74 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 167644216 Common - CHAP domain containing protein Caul_0244 12 COG3942 COG3942, Surface antigen General function prediction only 167647418 Common - putative secreted protein Caul_3456 4 None None None 167644078 Common - large conductance mechanosensitive channel protein Caul_0105 138 COG1970 MscL, Large-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 167647501 Common - Lysine exporter protein (LYSE/YGGA) Caul_3539 86 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 167647945 Common - NAD-dependent epimerase/dehydratase Caul_3985 141 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167646578 Common - Na+/H+ antiporter NhaA Caul_2616 106 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 167648854 Common - drug resistance transporter, Bcr/CflA subfamily Caul_4899 222 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167644680 Common - putative secreted protein Caul_0712 4 COG5455 COG5455, Predicted integral membrane protein Function unknown 167646571 Common - aminotransferase class IV Caul_2609 181 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 167644141 Nonpathogen - hypothetical protein Caul_0169 2 None None None 167647063 Common - UDP-3-0-acyl N-acetylglucosamine deacetylase Caul_3101 139 COG0774 LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase Cell envelope biogenesis, outer membrane 167646803 Common - band 7 protein Caul_2841 46 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 167645657 Nonpathogen - hypothetical protein Caul_1693 2 None None None 167647792 Common - P-type conjugative transfer protein TrbJ Caul_3831 22 COG5314 COG5314, Conjugal transfer/entry exclusion protein Intracellular trafficking and secretion 167644175 Common - hypothetical protein Caul_0203 10 None None None 167647584 Common - Beta-glucosidase Caul_3622 99 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 167648440 Nonpathogen - hypothetical protein Caul_4485 1 None None None 167648651 Common - N-carbamoylputrescine amidase Caul_4696 163 COG0388 COG0388, Predicted amidohydrolase General function prediction only 167647824 Common - major facilitator superfamily MFS_1 Caul_3863 82 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 167645678 Common - Methylenetetrahydrofolate dehydrogenase (NADP(+)) Caul_1714 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 167648995 Common - Smr protein/MutS2 Caul_5040 35 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 167647168 Common - TAP domain protein Caul_3206 24 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167647675 Common - amidohydrolase, AtzE family Caul_3713 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 167646839 Common - oxidoreductase domain protein Caul_2877 55 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 167645878 Common - glutathione peroxidase Caul_1914 114 COG0386 BtuE, Glutathione peroxidase Posttranslational modification, protein turnover, chaperones 167645279 Common - integral membrane sensor hybrid histidine kinase Caul_1314 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167644611 Nonpathogen - hypothetical protein Caul_0643 1 None None None 167648294 Common - peptidase M28 Caul_4339 9 COG2234 Iap, Predicted aminopeptidases General function prediction only 167648174 Common - UspA domain protein Caul_4215 35 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 167644260 Common - TonB-dependent receptor Caul_0288 33 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 167645549 Common - protein of unknown function DUF1345 Caul_1584 40 COG4291 COG4291, Predicted membrane protein Function unknown 167648904 Common - Citrate synthase Caul_4949 88 COG0372 GltA, Citrate synthase Energy production and conversion 167647699 Common - GCN5-related N-acetyltransferase Caul_3737 16 COG3393 COG3393, Predicted acetyltransferase General function prediction only 167645434 Nonpathogen - hypothetical protein Caul_1469 1 None None None 167647692 Common - Integrase catalytic region Caul_3730 146 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 167644413 Common - Carotenoid oxygenase Caul_0441 36 COG3670 COG3670, Lignostilbene-alpha,beta-dioxygenase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 167644269 Common - tryptophan halogenase Caul_0297 16 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 167647852 Common - CcmE/CycJ protein Caul_3892 92 COG2332 CcmE, Cytochrome c-type biogenesis protein CcmE Posttranslational modification, protein turnover, chaperones 167647928 Common - integral membrane sensor signal transduction histidine kinase Caul_3968 166 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167648198 Common - K+-transporting ATPase, B subunit Caul_4241 232 COG2216 KdpB, High-affinity K+ transport system, ATPase chain B Inorganic ion transport and metabolism 167648049 Common - alpha amylase catalytic region Caul_4090 153 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 167645833 Common - transcriptional regulator, AsnC family Caul_1869 132 COG1522 Lrp, Transcriptional regulators Transcription 167644073 Common - hypothetical protein Caul_0100 23 COG4530 COG4530, Uncharacterized protein conserved in bacteria Function unknown 167646680 Common - methyltransferase FkbM family Caul_2718 3 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 167645697 Common - pyridoxal phosphate biosynthetic protein PdxJ Caul_1733 139 COG0854 PdxJ, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 167644999 Nonpathogen - hypothetical protein Caul_1034 1 None None None 167646841 Common - single-strand binding protein Caul_2879 201 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 167645767 Common - Acetamidase/Formamidase Caul_1803 66 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 167644221 Common - Enoyl-CoA hydratase/isomerase Caul_0249 147 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 167644547 Common - AMP-dependent synthetase and ligase Caul_0579 215 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167645045 Common - TonB-dependent receptor Caul_1080 117 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 167645417 Nonpathogen - hypothetical protein Caul_1452 1 None None None 167648092 Nonpathogen - hypothetical protein Caul_4133 1 None None None 167646769 Common - glutathione-dependent formaldehyde-activating GFA Caul_2807 54 COG3791 COG3791, Uncharacterized conserved protein Function unknown 167645855 Common - short-chain dehydrogenase/reductase SDR Caul_1891 234 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167647424 Nonpathogen - hypothetical protein Caul_3462 1 None None None 167647498 Common - aspartate 1-decarboxylase Caul_3536 130 COG0853 PanD, Aspartate 1-decarboxylase Coenzyme metabolism 167646542 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Caul_2580 224 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 167647088 Nonpathogen - hypothetical protein Caul_3126 1 None None None 167645377 Common - HhH-GPD family protein Caul_1412 218 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 167648042 Common - glycoside hydrolase family 2 sugar binding Caul_4083 71 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 167648149 Common - type II secretion system protein E Caul_4190 157 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 167644361 Common - SNARE associated Golgi protein Caul_0389 59 COG0398 COG0398, Uncharacterized conserved protein Function unknown 167645312 Common - AMP-dependent synthetase and ligase Caul_1347 219 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167646760 Common - membrane-associated zinc metalloprotease Caul_2798 209 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 167645500 Nonpathogen - hypothetical protein Caul_1535 1 None None None 167648292 Common - protein of unknown function UPF0061 Caul_4337 110 COG0397 COG0397, Uncharacterized conserved protein Function unknown 167648366 Common - ABC-2 type transporter Caul_4411 169 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 167646946 Common - hypothetical protein Caul_2984 56 COG2187 COG2187, Uncharacterized protein conserved in bacteria Function unknown 167644537 Nonpathogen - hypothetical protein Caul_0569 1 None None None 167648036 Common - PHP domain protein Caul_4076 25 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 167644638 Nonpathogen - hypothetical protein Caul_0670 4 None None None 167646476 Common - fatty acid hydroxylase Caul_2514 17 COG3000 ERG3, Sterol desaturase Lipid metabolism 167646783 Common - proton-translocating NADH-quinone oxidoreductase, chain L Caul_2821 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 167647464 Nonpathogen - hypothetical protein Caul_3502 1 None None None 167648200 Nonpathogen - hypothetical protein Caul_4243 1 None None None 167645504 Common - Undecaprenyl-phosphate glucose phosphotransferase Caul_1539 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 167647815 Nonpathogen - thiamineS protein Caul_3854 1 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 167645759 Common - flavin reductase domain protein FMN-binding Caul_1795 127 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 167647943 Common - peptidylprolyl isomerase FKBP-type Caul_3983 136 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 167648172 Common - ABC transporter related Caul_4213 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 167648015 Nonpathogen - hypothetical protein Caul_4055 1 None None None 167648745 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Caul_4790 179 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 167647333 Nonpathogen - Post-segregation antitoxin CcdA Caul_3371 2 COG5302 COG5302, Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid General function prediction only 167648004 Nonpathogen - GCN5-related N-acetyltransferase Caul_4044 4 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 167646045 Common - capsule polysaccharide export-like protein Caul_2082 33 COG3524 KpsE, Capsule polysaccharide export protein Cell envelope biogenesis, outer membrane 167645293 Common - ABC transporter related Caul_1328 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 167646003 Nonpathogen - hypothetical protein Caul_2040 1 None None None 167647558 Common - MaoC domain protein dehydratase Caul_3596 79 COG2030 MaoC, Acyl dehydratase Lipid metabolism 167647150 Common - drug resistance transporter, EmrB/QacA subfamily Caul_3188 211 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167648914 Common - Exopolysaccharide synthesis ExoD Caul_4959 23 COG3932 COG3932, Uncharacterized ABC-type transport system, permease components General function prediction only 167648354 Nonpathogen - OsmC family protein Caul_4399 7 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 167647136 Common - hypothetical protein Caul_3174 23 None None None 167646606 Nonpathogen - hypothetical protein Caul_2644 2 None None None 167647551 Common - protein of unknown function DUF205 Caul_3589 166 COG0344 COG0344, Predicted membrane protein Function unknown 167646998 Common - hypothetical protein Caul_3036 22 COG5452 COG5452, Uncharacterized conserved protein Function unknown 167644682 Common - heat shock protein DnaJ domain protein Caul_0714 35 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 167645704 Common - DNA repair protein RecO Caul_1740 40 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 167647445 Common - protein of unknown function DUF264 Caul_3483 21 COG5323 COG5323, Uncharacterized conserved protein Function unknown 167646317 Common - TonB-dependent receptor Caul_2355 99 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 167646108 Nonpathogen - hypothetical protein Caul_2145 1 None None None 167644142 Nonpathogen - hypothetical protein Caul_0170 1 None None None 167647978 Common - hypothetical protein Caul_4018 38 COG3744 COG3744, Uncharacterized protein conserved in bacteria Function unknown 167646488 Common - 4-hydroxythreonine-4-phosphate dehydrogenase Caul_2526 159 COG1995 PdxA, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 167644477 Common - 3-isopropylmalate dehydratase, small subunit Caul_0508 210 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 167646574 Common - glycoside hydrolase family 24 Caul_2612 46 COG3772 COG3772, Phage-related lysozyme (muraminidase) General function prediction only 167645750 Common - arsenical-resistance protein Caul_1786 125 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 167647961 Common - short-chain dehydrogenase/reductase SDR Caul_4001 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167646416 Common - UspA domain protein Caul_2454 44 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 167646668 Common - ribonuclease BN Caul_2706 32 COG1295 Rbn, Predicted membrane protein Function unknown 167645374 Common - methylmalonate-semialdehyde dehydrogenase Caul_1409 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167646822 Common - AMP-dependent synthetase and ligase Caul_2860 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167647356 Nonpathogen - hypothetical protein Caul_3394 1 None None None 167648418 Common - hypothetical protein Caul_4463 20 COG4544 COG4544, Uncharacterized conserved protein Function unknown 167648936 Nonpathogen - 17 kDa surface antigen Caul_4981 1 COG3134 COG3134, Predicted outer membrane lipoprotein Function unknown 167646088 Common - anti-FecI sigma factor, FecR Caul_2125 49 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 167644460 Common - alpha/beta hydrolase fold Caul_0491 65 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167645773 Common - Tetratricopeptide TPR_2 repeat protein Caul_1809 4 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 167646966 Common - putative lipid carrier protein-like protein Caul_3004 13 COG3154 COG3154, Putative lipid carrier protein Lipid metabolism 167645529 Common - hypothetical protein Caul_1564 23 COG3501 VgrG, Uncharacterized protein conserved in bacteria Function unknown 167647911 Common - extracellular solute-binding protein family 1 Caul_3951 134 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 167648395 Common - Saccharopine dehydrogenase Caul_4440 52 COG1748 LYS9, Saccharopine dehydrogenase and related proteins Amino acid transport and metabolism 167648243 Common - restriction endonuclease Caul_4287 40 COG1715 Mrr, Restriction endonuclease Defense mechanisms 167644085 Common - Creatininase Caul_0112 84 COG1402 COG1402, Uncharacterized protein, putative amidase General function prediction only 167644382 Common - MltA-interacting MipA family protein Caul_0410 37 COG3713 OmpV, Outer membrane protein V Cell envelope biogenesis, outer membrane 167647908 Common - spermidine/putrescine ABC transporter ATPase subunit Caul_3948 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 167646864 Nonpathogen - hypothetical protein Caul_2902 1 None None None 167648615 Nonpathogen - hypothetical protein Caul_4660 1 None None None 167645139 Nonpathogen - hypothetical protein Caul_1174 1 None None None 167645532 Nonpathogen - hypothetical protein Caul_1567 17 None None None 167644501 Common - protein of unknown function DUF6 transmembrane Caul_0532 57 COG2510 COG2510, Predicted membrane protein Function unknown 167645297 Common - VacJ family lipoprotein Caul_1332 94 COG2853 VacJ, Surface lipoprotein Cell envelope biogenesis, outer membrane 167645430 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Caul_1465 4 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 167646891 Common - peptidase M56 BlaR1 Caul_2929 109 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 167645043 Common - penicillin-binding protein, 1A family Caul_1078 202 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 167648711 Common - DNA-cytosine methyltransferase Caul_4756 57 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 167646237 Common - P-type conjugative transfer protein TrbG Caul_2275 40 COG3504 VirB9, Type IV secretory pathway, VirB9 components Intracellular trafficking and secretion 167647844 Nonpathogen - hypothetical protein Caul_3884 1 None None None 167647175 Common - diaminopimelate decarboxylase Caul_3213 218 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 167645617 Nonpathogen - hypothetical protein Caul_1653 1 None None None 167646844 Common - regulatory protein FlaEY Caul_2882 33 None None None 167647606 Common - hypothetical protein Caul_3644 46 COG2378 COG2378, Predicted transcriptional regulator Transcription 167647422 Common - short-chain dehydrogenase/reductase SDR Caul_3460 228 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 167646565 Common - 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Caul_2603 192 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 167644010 Common - dienelactone hydrolase Caul_0037 10 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 167645444 Common - aminotransferase class I and II Caul_1479 236 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 167647002 Nonpathogen - hypothetical protein Caul_3040 6 None None None 167644245 Common - peptidase S8 and S53 subtilisin kexin sedolisin Caul_0273 137 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 167645927 Common - hypothetical protein Caul_1963 36 COG3247 HdeD, Uncharacterized conserved protein Function unknown 167644565 Nonpathogen - hypothetical protein Caul_0597 1 None None None 167644326 Common - UbiD family decarboxylase Caul_0354 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 167648754 Nonpathogen - hypothetical protein Caul_4799 1 None None None 167644153 Common - OmpA/MotB domain protein Caul_0181 169 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 167646164 Common - peptidase dimerisation domain protein Caul_2201 147 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 167648963 Common - outer membrane lipoprotein carrier protein LolA Caul_5008 39 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 167648424 Nonpathogen - hypothetical protein Caul_4469 1 None None None 167645050 Nonpathogen - hypothetical protein Caul_1085 1 None None None 167647616 Common - aminotransferase class I and II Caul_3654 237 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 167647728 Nonpathogen - hypothetical protein Caul_3766 1 None None None 167646694 Common - molybdate ABC transporter, inner membrane subunit Caul_2732 224 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 167644017 Common - TonB-dependent siderophore receptor Caul_0044 93 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 167649025 Common - phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase Caul_5070 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 167644371 Common - transcriptional regulator, XRE family Caul_0399 11 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 167645073 Common - transposase IS4 family protein Caul_1108 50 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 167648121 Common - outer membrane adhesin like proteiin Caul_4162 122 COG2931 COG2931, RTX toxins and related Ca2+-binding proteins Secondary metabolites biosynthesis, transport, and catabolism 167648977 Nonpathogen - hypothetical protein Caul_5022 11 None None None 167647126 Common - protein of unknown function DUF336 Caul_3164 18 COG3193 GlcG, Uncharacterized protein, possibly involved in utilization of glycolate and propanediol General function prediction only 167646881 Common - Deoxyribodipyrimidine photo-lyase Caul_2919 135 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 167647068 Common - protein of unknown function DUF498 Caul_3106 47 COG3737 COG3737, Uncharacterized conserved protein Function unknown 167645714 Common - sulfate adenylyltransferase, small subunit Caul_1750 139 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 167648338 Common - Glycine dehydrogenase (decarboxylating) Caul_4383 172 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 167648567 Common - nucleoside:H symporter Caul_4612 37 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 167648145 Common - hypothetical protein Caul_4186 16 COG4391 COG4391, Uncharacterized protein conserved in bacteria Function unknown 167646333 Common - Prolyl oligopeptidase Caul_2371 114 COG1505 COG1505, Serine proteases of the peptidase family S9A Amino acid transport and metabolism 167647438 Common - integrase family protein Caul_3476 61 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 167644761 Common - DNA-directed RNA polymerase, beta' subunit Caul_0795 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 167647360 Common - protein of unknown function DUF885 Caul_3398 43 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 167646230 Common - P-type conjugative transfer ATPase TrbB Caul_2268 211 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 167647576 Common - GntR domain protein Caul_3614 123 COG2186 FadR, Transcriptional regulators Transcription 167645366 Common - protein of unknown function DUF350 Caul_1401 24 COG3766 COG3766, Predicted membrane protein Function unknown 167646930 Common - two component transcriptional regulator, LuxR family Caul_2968 225 COG4566 TtrR, Response regulator Signal transduction mechanisms 167647686 Common - transcriptional regulator, BadM/Rrf2 family Caul_3724 166 COG1959 COG1959, Predicted transcriptional regulator Transcription 167644946 Common - hypothetical protein Caul_0981 64 None None None 167645652 Common - AMP-dependent synthetase and ligase Caul_1688 209 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167647349 Common - Dihydrofolate reductase Caul_3387 146 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 167648411 Nonpathogen - hypothetical protein Caul_4456 1 None None None 167646212 Common - Type IV secretory pathway protease TraF-like protein Caul_2250 25 COG4959 TraF, Type IV secretory pathway, protease TraF Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 167645555 Common - ATP-dependent helicase HrpB Caul_1590 131 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 167644774 Common - RND efflux system, outer membrane lipoprotein, NodT family Caul_0808 107 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 167647799 Common - transcriptional regulator, LysR family Caul_3838 191 COG0583 LysR, Transcriptional regulator Transcription 167646061 Common - general secretion pathway protein D Caul_2098 141 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 167646799 Common - hypothetical protein Caul_2837 23 COG5207 UBP14, Isopeptidase T Posttranslational modification, protein turnover, chaperones 167648472 Nonpathogen - hypothetical protein Caul_4517 1 None None None 167644828 Common - N-formylglutamate amidohydrolase Caul_0862 56 COG3741 HutG, N-formylglutamate amidohydrolase Amino acid transport and metabolism 167645893 Common - amidohydrolase 2 Caul_1929 49 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 167648927 Common - Integrase catalytic region Caul_4972 146 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 167645057 Common - major facilitator superfamily MFS_1 Caul_1092 137 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167645949 Common - asparagine synthase Caul_1986 4 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 167648909 Common - 3'-5' exonuclease Caul_4954 105 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 167648096 Nonpathogen - hypothetical protein Caul_4137 1 None None None 167648444 Common - acyl-CoA dehydrogenase domain protein Caul_4489 146 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167645427 Nonpathogen - hypothetical protein Caul_1462 1 None None None 167645537 Nonpathogen - hypothetical protein Caul_1572 1 None None None 167647601 Common - protein of unknown function DUF519 Caul_3639 84 COG2961 ComJ, Protein involved in catabolism of external DNA General function prediction only 167646795 Common - NADH dehydrogenase I, D subunit Caul_2833 191 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 167644622 Common - L-serine dehydratase 1 Caul_0654 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 167648627 Common - potassium efflux system protein Caul_4672 191 COG4651 RosB, Kef-type K+ transport system, predicted NAD-binding component Inorganic ion transport and metabolism 167648533 Common - putative transposase of insertion sequence ISRm2011-2, orfA protein Caul_4578 20 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 167645332 Common - flagellar basal-body rod protein FlgC Caul_1367 126 COG1558 FlgC, Flagellar basal body rod protein Cell motility and secretion 167645676 Common - phytoene desaturase Caul_1712 97 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 167647129 Nonpathogen - hypothetical protein Caul_3167 2 None None None 167648538 Common - thiol-disulfide isomerase Caul_4583 11 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 167646510 Common - TonB-dependent receptor Caul_2548 104 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 167647450 Nonpathogen - hypothetical protein Caul_3488 1 None None None 167646196 Nonpathogen - hypothetical protein Caul_2234 1 None None None 167647582 Common - Amidase Caul_3620 218 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 167645635 Common - nucleotidyltransferase family protein Caul_1671 133 COG1213 COG1213, Predicted sugar nucleotidyltransferases Cell envelope biogenesis, outer membrane 167644095 Nonpathogen - hypothetical protein Caul_0122 2 None None None 167644640 Common - protein of unknown function DUF152 Caul_0672 178 COG1496 COG1496, Uncharacterized conserved protein Function unknown 167648264 Common - L-aspartate oxidase Caul_4309 226 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 167644908 Common - protein of unknown function DUF1178 Caul_0942 47 COG5319 COG5319, Uncharacterized protein conserved in bacteria Function unknown 167645190 Common - hypothetical protein Caul_1225 23 COG3908 COG3908, Uncharacterized protein conserved in bacteria Function unknown 167648026 Common - adenosine/AMP deaminase Caul_4066 61 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 167648631 Common - protein of unknown function DUF461 Caul_4676 81 COG2847 COG2847, Uncharacterized protein conserved in bacteria Function unknown 167644134 Common - DNA polymerase III, beta subunit Caul_0162 216 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 167647082 Common - segregation and condensation protein B Caul_3120 144 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 167647089 Common - exodeoxyribonuclease III Xth Caul_3127 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 167644648 Common - beta-lactamase domain protein Caul_0680 85 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 167646644 Common - hypothetical protein Caul_2682 92 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 167644524 Common - transcriptional regulator, TetR family Caul_0556 51 COG1309 AcrR, Transcriptional regulator Transcription 167646886 Common - transposase IS116/IS110/IS902 family protein Caul_2924 63 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 167645522 Nonpathogen - hypothetical protein Caul_1557 1 None None None 167645725 Common - PfkB domain protein Caul_1761 64 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 167647536 Common - hypothetical protein Caul_3574 15 None None None 167645668 Common - ATP12 ATPase Caul_1704 33 COG5387 COG5387, Chaperone required for the assembly of the mitochondrial F1-ATPase Posttranslational modification, protein turnover, chaperones 167647428 Common - glutaredoxin-like protein Caul_3466 127 COG0278 COG0278, Glutaredoxin-related protein Posttranslational modification, protein turnover, chaperones 167648728 Common - multiple antibiotic resistance (MarC)-related protein Caul_4773 147 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 167644964 Common - hypothetical protein Caul_0999 40 COG2388 COG2388, Predicted acetyltransferase General function prediction only 167648295 Common - AMP-dependent synthetase and ligase Caul_4340 201 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167645199 Common - Hsp33 protein Caul_1234 137 COG1281 COG1281, Disulfide bond chaperones of the HSP33 family Posttranslational modification, protein turnover, chaperones 167645439 Common - TonB-dependent siderophore receptor Caul_1474 122 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 167648183 Common - hypothetical protein Caul_4226 13 None None None 167647371 Common - 5,10-methylenetetrahydrofolate reductase Caul_3409 139 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 167646914 Common - fatty acid desaturase Caul_2952 27 COG3239 DesA, Fatty acid desaturase Lipid metabolism 167646068 Common - MotA/TolQ/ExbB proton channel Caul_2105 127 COG5306 COG5306, Uncharacterized conserved protein Function unknown 167648769 Common - type I secretion system ATPase Caul_4814 249 COG4618 ArpD, ABC-type protease/lipase transport system, ATPase and permease components General function prediction only 167648300 Common - dihydroneopterin aldolase Caul_4345 63 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 167645408 Common - pyruvate kinase Caul_1443 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 167646756 Common - beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ Caul_2794 186 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 167646530 Common - thiazole biosynthesis family protein Caul_2568 166 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 167648564 Common - Xylose isomerase domain protein TIM barrel Caul_4609 61 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 167645201 Common - Fe-S metabolism associated SufE Caul_1236 93 COG2166 COG2166, SufE protein probably involved in Fe-S center assembly General function prediction only 167646950 Nonpathogen - hypothetical protein Caul_2988 7 COG4341 COG4341, Predicted HD phosphohydrolase General function prediction only 167645037 Nonpathogen - hypothetical protein Caul_1072 1 None None None 167647217 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Caul_3255 39 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 167645827 Nonpathogen - hypothetical protein Caul_1863 1 None None None 167647716 Common - nitroreductase Caul_3754 55 COG0778 NfnB, Nitroreductase Energy production and conversion 167645684 Common - hypothetical protein Caul_1720 17 COG5330 COG5330, Uncharacterized protein conserved in bacteria Function unknown 167647702 Nonpathogen - hypothetical protein Caul_3740 1 None None None 167648951 Common - hypothetical protein Caul_4996 10 COG3918 COG3918, Predicted membrane protein Function unknown 167644689 Common - 3-dehydroquinate synthase Caul_0721 215 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 167645340 Common - ABC transporter related Caul_1375 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 167645602 Common - DNA-directed RNA polymerase, alpha subunit Caul_1638 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 167645944 Nonpathogen - hypothetical protein Caul_1981 6 COG5419 COG5419, Uncharacterized conserved protein Function unknown 167645274 Common - heat shock protein DnaJ domain protein Caul_1309 18 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 167645307 Common - GCN5-related N-acetyltransferase Caul_1342 123 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 167644485 Common - TonB-dependent receptor Caul_0516 118 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167648514 Common - pyrimidine 5'-nucleotidase Caul_4559 47 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 167647705 Common - integral membrane sensor hybrid histidine kinase Caul_3743 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167648789 Common - PAS/PAC sensor signal transduction histidine kinase Caul_4834 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167645387 Common - CinA domain protein Caul_1422 190 COG1546 CinA, Uncharacterized protein (competence- and mitomycin-induced) General function prediction only 167645303 Nonpathogen - hypothetical protein Caul_1338 1 None None None 167648309 Nonpathogen - YhhN family protein Caul_4354 4 COG3714 COG3714, Predicted membrane protein Function unknown 167644854 Common - alpha/beta hydrolase fold Caul_0888 37 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167645220 Nonpathogen - hypothetical protein Caul_1255 1 None None None 167647181 Common - protein of unknown function DUF218 Caul_3219 30 COG1434 COG1434, Uncharacterized conserved protein Function unknown 167648018 Common - lipoprotein signal peptidase Caul_4058 156 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 167646714 Common - lysophospholipase L2, putative Caul_2752 55 COG2267 PldB, Lysophospholipase Lipid metabolism 167647415 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Caul_3453 155 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 167647283 Common - hypothetical protein Caul_3321 59 COG3825 COG3825, Uncharacterized protein conserved in bacteria Function unknown 167646097 Common - lipolytic protein G-D-S-L family Caul_2134 18 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 167646722 Common - pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit Caul_2760 154 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 167646988 Common - ribosomal protein L13 Caul_3026 219 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 167644161 Common - hypothetical protein Caul_0189 73 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 167646359 Nonpathogen - hypothetical protein Caul_2397 2 None None None 167646985 Common - PilT protein domain protein Caul_3023 21 COG5611 COG5611, Predicted nucleic-acid-binding protein, contains PIN domain General function prediction only 167647855 Common - integral membrane sensor signal transduction histidine kinase Caul_3895 200 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167647906 Common - aminotransferase class-III Caul_3946 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 167645850 Common - acyl-CoA dehydrogenase domain protein Caul_1886 156 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167648934 Common - FolC bifunctional protein Caul_4979 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 167644440 Common - signal transduction histidine kinase Caul_0471 112 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 167646288 Common - outer membrane efflux protein Caul_2326 38 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 167647624 Common - UDP-N-acetylenolpyruvoylglucosamine reductase Caul_3662 207 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 167645786 Nonpathogen - hypothetical protein Caul_1822 11 None None None 167645142 Common - Glutathione S-transferase domain Caul_1177 99 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167647918 Common - protein of unknown function DUF559 Caul_3958 46 COG2852 COG2852, Uncharacterized protein conserved in bacteria Function unknown 167646509 Common - histidine kinase Caul_2547 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167647106 Common - Endoribonuclease L-PSP Caul_3144 92 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 167646081 Common - Capsule polysaccharide biosynthesis protein Caul_2118 30 COG3562 KpsS, Capsule polysaccharide export protein Cell envelope biogenesis, outer membrane 167646206 Common - anti-FecI sigma factor, FecR Caul_2244 48 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 167645149 Common - peptide methionine sulfoxide reductase Caul_1184 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 167648322 Common - DNA methylase N-4/N-6 domain protein Caul_4367 145 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 167646705 Common - cobalamin 5'-phosphate synthase Caul_2743 7 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 167647587 Common - 5-oxoprolinase (ATP-hydrolyzing) Caul_3625 115 COG0146 HyuB, N-methylhydantoinase B/acetone carboxylase, alpha subunit Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167648483 Common - hypothetical protein Caul_4528 5 COG4891 COG4891, Uncharacterized conserved protein Function unknown 167644168 Common - cobalamin synthesis protein P47K Caul_0196 127 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 167644063 Nonpathogen - hypothetical protein Caul_0090 1 None None None 167645615 Common - AAA ATPase central domain protein Caul_1651 213 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 167644556 Common - transcriptional regulator, TetR family Caul_0588 50 COG1309 AcrR, Transcriptional regulator Transcription 167645881 Common - Rieske (2Fe-2S) domain protein Caul_1917 82 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 167647831 Common - hypothetical protein Caul_3870 6 None None None 167647674 Nonpathogen - hypothetical protein Caul_3712 1 None None None 167646125 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Caul_2162 108 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 167644667 Common - Coproporphyrinogen oxidase Caul_0699 112 COG0408 HemF, Coproporphyrinogen III oxidase Coenzyme metabolism 167645254 Common - TonB-dependent receptor Caul_1289 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167645711 Common - methionyl-tRNA synthetase Caul_1747 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 167647235 Nonpathogen - hypothetical protein Caul_3273 6 None None None 167645576 Nonpathogen - hypothetical protein Caul_1612 1 None None None 167644155 Common - Flp pilus assembly protein TadG Caul_0183 16 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 167648524 Nonpathogen - hypothetical protein Caul_4569 1 None None None 167647974 Common - major facilitator superfamily MFS_1 Caul_4014 123 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167644574 Common - hypothetical protein Caul_0606 12 None None None 167647875 Nonpathogen - hypothetical protein Caul_3915 3 None None None 167645492 Common - hypothetical protein Caul_1527 21 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 167644497 Common - transcriptional regulator, TetR family Caul_0528 40 COG1309 AcrR, Transcriptional regulator Transcription 167646814 Common - nitrogen regulatory protein P-II Caul_2852 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 167644783 Nonpathogen - hypothetical protein Caul_0817 1 None None None 167644704 Common - 2-nitropropane dioxygenase NPD Caul_0738 119 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 167645036 Nonpathogen - hypothetical protein Caul_1071 1 None None None 167644607 Common - GTP-binding protein HSR1-related Caul_0639 183 COG0218 COG0218, Predicted GTPase General function prediction only 167644126 Common - transcriptional regulator, MarR family Caul_0154 31 COG0456 RimI, Acetyltransferases General function prediction only 167646546 Common - 3-demethylubiquinone-9 3-methyltransferase Caul_2584 46 COG3865 COG3865, Uncharacterized protein conserved in bacteria Function unknown 167647474 Common - peptidase M48 Ste24p Caul_3512 189 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 167646489 Common - SurA domain Caul_2527 130 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 167645572 Common - cyclic nucleotide-regulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase Caul_1608 244 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 167648426 Common - integral membrane sensor hybrid histidine kinase Caul_4471 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167644813 Common - major facilitator superfamily MFS_1 Caul_0847 181 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167644182 Common - GCN5-related N-acetyltransferase Caul_0210 48 COG0456 RimI, Acetyltransferases General function prediction only 167644312 Common - Integrase catalytic region Caul_0340 146 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 167645174 Nonpathogen - hypothetical protein Caul_1209 1 None None None 167648877 Common - GHMP kinase Caul_4922 35 COG2605 COG2605, Predicted kinase related to galactokinase and mevalonate kinase General function prediction only 167645969 Common - integrase family protein Caul_2006 207 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 167647744 Nonpathogen - hypothetical protein Caul_3782 1 None None None 167644255 Common - response regulator receiver protein Caul_0283 209 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 167644296 Common - N-6 DNA methylase Caul_0324 147 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 167648347 Common - death-on-curing family protein Caul_4392 63 COG3654 Doc, Prophage maintenance system killer protein General function prediction only 167646622 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Caul_2660 228 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 167645003 Nonpathogen - hypothetical protein Caul_1038 2 None None None 167644779 Common - 3-hydroxyacyl-CoA dehydrogenase NAD-binding Caul_0813 192 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 167645977 Common - hypothetical protein Caul_2014 18 None None None 167648544 Common - peptidase S16 lon domain protein Caul_4589 41 COG2802 COG2802, Uncharacterized protein, similar to the N-terminal domain of Lon protease General function prediction only 167647820 Common - NnrS family protein Caul_3859 55 COG3213 NnrS, Uncharacterized protein involved in response to NO Inorganic ion transport and metabolism 167645608 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Caul_1644 49 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 167648983 Common - DNA polymerase III, delta subunit Caul_5028 26 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 167645180 Common - hypothetical protein Caul_1215 21 COG4798 COG4798, Predicted methyltransferase General function prediction only 167645463 Common - glutamine cyclotransferase Caul_1498 22 COG3823 COG3823, Glutamine cyclotransferase Posttranslational modification, protein turnover, chaperones 167646647 Common - two component transcriptional regulator, LuxR family Caul_2685 216 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 167644750 Common - crossover junction endodeoxyribonuclease RuvC Caul_0784 195 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 167644795 Common - putative RNA polymerase, sigma-24 subunit, ECF subfamily Caul_0829 48 COG4941 COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain Transcription 167647145 Common - peptidase, M6 (immune inhibitor A) family Caul_3183 20 COG4412 COG4412, Uncharacterized protein conserved in bacteria Function unknown 167645908 Common - transposase IS3/IS911 family protein Caul_1944 27 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646074 Common - peptidase M23B Caul_2111 189 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 167644391 Common - glucose-methanol-choline oxidoreductase Caul_0419 88 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 167648384 Common - protein TolR Caul_4429 136 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 167646874 Common - DEAD/DEAH box helicase domain protein Caul_2912 210 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 167647329 Common - fumarate hydratase, class II Caul_3367 219 COG0114 FumC, Fumarase Energy production and conversion 167647294 Common - Glutathione S-transferase domain Caul_3332 95 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167644512 Common - transcriptional regulator, LysR family Caul_0543 89 COG0583 LysR, Transcriptional regulator Transcription 167648776 Nonpathogen - hypothetical protein Caul_4821 1 None None None 167648053 Common - ABC transporter related Caul_4094 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 167646405 Common - heavy metal translocating P-type ATPase Caul_2443 230 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 167647662 Nonpathogen - hypothetical protein Caul_3700 1 None None None 167647056 Common - tRNA/rRNA methyltransferase (SpoU) Caul_3094 197 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 167646576 Common - major facilitator superfamily MFS_1 Caul_2614 84 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 167647186 Nonpathogen - hypothetical protein Caul_3224 8 COG4093 COG4093, Uncharacterized protein conserved in bacteria Function unknown 167645336 Common - GCN5-related N-acetyltransferase Caul_1371 45 COG0456 RimI, Acetyltransferases General function prediction only 167645859 Common - acyl-CoA dehydrogenase domain protein Caul_1895 149 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167646187 Nonpathogen - hypothetical protein Caul_2224 1 None None None 167647954 Nonpathogen - hypothetical protein Caul_3994 1 None None None 167648680 Common - integral membrane sensor hybrid histidine kinase Caul_4725 225 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167647680 Common - xanthine dehydrogenase accessory protein XdhC Caul_3718 101 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 167646583 Common - transcriptional regulator, ArsR family Caul_2621 99 COG0640 ArsR, Predicted transcriptional regulators Transcription 167647272 Common - Glutathione S-transferase domain Caul_3310 85 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167645494 Common - lipopolysaccharide biosynthesis protein Caul_1529 19 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 167648999 Common - imidazole glycerol phosphate synthase, glutamine amidotransferase subunit Caul_5044 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 167644767 Common - ribosomal protein S12 Caul_0801 239 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 167646743 Nonpathogen - hypothetical protein Caul_2781 1 None None None 167646650 Common - secretion protein HlyD family protein Caul_2688 106 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 167648468 Nonpathogen - hypothetical protein Caul_4513 2 None None None 167648111 Nonpathogen - hypothetical protein Caul_4152 2 COG5513 COG5513, Predicted secreted protein Function unknown 167647350 Nonpathogen - hypothetical protein Caul_3388 1 None None None 167644621 Common - transcriptional regulator, XRE family Caul_0653 30 COG2944 COG2944, Predicted transcriptional regulator Transcription 167648961 Common - hypothetical protein Caul_5006 34 COG3812 COG3812, Uncharacterized protein conserved in bacteria Function unknown 167645479 Nonpathogen - hypothetical protein Caul_1514 1 None None None 167645550 Nonpathogen - hypothetical protein Caul_1585 2 COG4907 COG4907, Predicted membrane protein Function unknown 167647273 Common - putative acetyl-CoA acetyltransferase Caul_3311 13 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167645717 Common - Mannitol dehydrogenase domain Caul_1753 90 COG0246 MtlD, Mannitol-1-phosphate/altronate dehydrogenases Carbohydrate transport and metabolism 167645480 Common - putative HlyD family secretion protein Caul_1515 117 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 167644267 Common - PTS system, N-acetylglucosamine-specific IIBC subunit Caul_0295 49 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 167647016 Nonpathogen - prevent-host-death family protein Caul_3054 5 COG4118 Phd, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 167645990 Common - P-type conjugative transfer ATPase TrbB Caul_2027 218 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 167644727 Common - translation elongation factor P Caul_0761 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 167644097 Nonpathogen - hypothetical protein Caul_0124 1 None None None 167645817 Common - tryptophan halogenase Caul_1853 16 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 167646076 Common - hypothetical protein Caul_2113 16 None None None 167648667 Common - GTP-binding protein Obg/CgtA Caul_4712 249 COG0536 Obg, Predicted GTPase General function prediction only 167649006 Common - hypothetical protein Caul_5051 9 COG4320 COG4320, Uncharacterized protein conserved in bacteria Function unknown 167647629 Common - cell division protein FtsW Caul_3667 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 167646181 Common - phage transcriptional regulator, AlpA Caul_2218 19 COG3311 AlpA, Predicted transcriptional regulator Transcription 167644889 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Caul_0923 124 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 167645392 Common - Mandelate racemase/muconate lactonizing protein Caul_1427 105 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 167646750 Common - flhB-related protein Caul_2788 114 COG2257 COG2257, Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB Function unknown 167647084 Common - Beta-N-acetylhexosaminidase Caul_3122 169 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 167647421 Common - transcriptional regulator, HxlR family Caul_3459 126 COG1733 COG1733, Predicted transcriptional regulators Transcription 167645108 Common - phage transcriptional regulator, AlpA Caul_1143 28 COG3311 AlpA, Predicted transcriptional regulator Transcription 167647506 Common - glutathione-disulfide reductase Caul_3544 246 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 167647795 Common - Conjugal transfer protein Caul_3834 34 COG3701 TrbF, Type IV secretory pathway, TrbF components Intracellular trafficking and secretion 167647074 Common - peptidase M23B Caul_3112 188 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 167645915 Common - ABC-2 type transporter Caul_1951 123 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 167644587 Nonpathogen - hypothetical protein Caul_0619 10 None None None 167646025 Common - transcriptional regulator, LacI family Caul_2062 127 COG1609 PurR, Transcriptional regulators Transcription 167646492 Common - permease YjgP/YjgQ family protein Caul_2530 121 COG0795 COG0795, Predicted permeases General function prediction only 167648761 Common - hypothetical protein Caul_4806 7 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 167648329 Common - protein of unknown function DUF81 Caul_4374 107 COG0730 COG0730, Predicted permeases General function prediction only 167645763 Common - short-chain dehydrogenase/reductase SDR Caul_1799 238 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 167648287 Common - flavoprotein WrbA Caul_4332 107 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 167645364 Common - amino acid permease-associated region Caul_1399 151 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 167646642 Common - FAD-linked oxidoreductase Caul_2680 34 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 167648554 Common - Carboxylesterase type B Caul_4599 66 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 167645207 Common - hypothetical protein Caul_1242 35 COG4340 COG4340, Uncharacterized protein conserved in bacteria Function unknown 167648506 Common - histidine kinase Caul_4551 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167645857 Common - Enoyl-CoA hydratase/isomerase Caul_1893 181 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 167646034 Nonpathogen - SMP-30/Gluconolaconase/LRE domain protein Caul_2071 10 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 167645487 Common - protein of unknown function DUF559 Caul_1522 46 COG2852 COG2852, Uncharacterized protein conserved in bacteria Function unknown 167646470 Common - replicative DNA helicase Caul_2508 215 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 167644056 Common - metallophosphoesterase Caul_0083 68 COG1409 Icc, Predicted phosphohydrolases General function prediction only 167646176 Common - inosine-5'-monophosphate dehydrogenase Caul_2213 241 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 167644609 Nonpathogen - ribonuclease P protein component Caul_0641 11 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 167644671 Common - cytochrome c1 Caul_0703 41 COG2857 CYT1, Cytochrome c1 Energy production and conversion 167647348 Common - thioesterase superfamily protein Caul_3386 3 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 167644756 Common - ribosomal protein L7/L12 Caul_0790 215 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 167646252 Common - heavy metal translocating P-type ATPase Caul_2290 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 167645735 Common - HAD-superfamily hydrolase, subfamily IIB Caul_1771 82 COG1877 OtsB, Trehalose-6-phosphatase Carbohydrate transport and metabolism 167647496 Common - protein of unknown function DUF541 Caul_3534 104 COG2968 COG2968, Uncharacterized conserved protein Function unknown 167648119 Common - transposase IS3/IS911 family protein Caul_4160 44 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 167647361 Common - peptidase M48 Ste24p Caul_3399 106 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 167645863 Common - protein of unknown function DUF6 transmembrane Caul_1899 95 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 167644930 Common - ROK family protein Caul_0965 50 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 167645633 Common - hypothetical protein Caul_1669 17 COG4341 COG4341, Predicted HD phosphohydrolase General function prediction only 167646151 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Caul_2188 189 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 167646092 Common - Alpha-galactosidase Caul_2129 20 COG3345 GalA, Alpha-galactosidase Carbohydrate transport and metabolism 167647638 Common - protein of unknown function UPF0040 Caul_3676 75 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 167646451 Nonpathogen - hypothetical protein Caul_2489 2 None None None 167645954 Common - transcriptional regulator, XRE family Caul_1991 55 COG1396 HipB, Predicted transcriptional regulators Transcription 167648156 Common - hypothetical protein Caul_4197 22 COG4964 CpaC, Flp pilus assembly protein, secretin CpaC Intracellular trafficking and secretion 167645238 Common - TonB-dependent receptor Caul_1273 24 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 167647931 Common - Galactose 1-dehydrogenase Caul_3971 160 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 167648831 Common - hypothetical protein Caul_4876 6 COG3692 COG3692, Uncharacterized protein conserved in bacteria Function unknown 167648916 Common - PTS IIA-like nitrogen-regulatory protein PtsN Caul_4961 136 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 167647766 Common - hypothetical protein Caul_3805 2 None None None 167644351 Common - Methyltransferase type 11 Caul_0379 58 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 167644250 Common - response regulator receiver protein Caul_0278 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 167647007 Common - 67-dimethyl-8-ribityllumazine synthase Caul_3045 197 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 167644023 Common - aldehyde oxidase and xanthine dehydrogenase molybdopterin binding Caul_0050 98 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 167646283 Common - hypothetical protein Caul_2321 6 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 167646503 Common - protein of unknown function DUF1275 Caul_2541 12 COG3619 COG3619, Predicted membrane protein Function unknown 167648000 Nonpathogen - FeoA family protein Caul_4040 4 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 167646152 Common - Endonuclease/exonuclease/phosphatase Caul_2189 27 COG3021 COG3021, Uncharacterized protein conserved in bacteria Function unknown 167644811 Common - DNA polymerase beta domain protein region Caul_0845 51 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 167647659 Common - excinuclease ABC, A subunit Caul_3697 241 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 167644669 Common - ubiquinol-cytochrome c reductase, iron-sulfur subunit Caul_0701 107 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 167647492 Common - Ethanolamine ammonia-lyase Caul_3530 52 COG4302 EutC, Ethanolamine ammonia-lyase, small subunit Amino acid transport and metabolism 167647205 Common - TonB-dependent receptor Caul_3243 113 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167646514 Common - DnaA-related protein Caul_2552 46 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 167645196 Common - acetylornithine and succinylornithine aminotransferase Caul_1231 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 167646086 Common - TonB-dependent receptor Caul_2123 31 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167646348 Common - Alcohol dehydrogenase zinc-binding domain protein Caul_2386 172 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 167646561 Nonpathogen - glycosyl transferase family 9 Caul_2599 5 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 167646259 Common - heavy metal efflux pump, CzcA family Caul_2297 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 167644086 Common - hypothetical protein Caul_0113 4 None None None 167649028 Common - sugar-phosphate isomerase, RpiB/LacA/LacB family Caul_5073 128 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 167643984 Common - integral membrane protein MviN Caul_0011 179 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 167646013 Nonpathogen - hypothetical protein Caul_2050 1 None None None 167646266 Common - fatty acid hydroxylase Caul_2304 52 COG3000 ERG3, Sterol desaturase Lipid metabolism 167646303 Common - Alcohol dehydrogenase GroES domain protein Caul_2341 208 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 167648138 Common - transcriptional regulator, XRE family Caul_4179 13 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 167645845 Common - thioesterase superfamily protein Caul_1881 14 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 167648993 Common - import inner membrane translocase subunit Tim44 Caul_5038 42 COG4395 COG4395, Uncharacterized protein conserved in bacteria Function unknown 167647640 Common - hypothetical protein Caul_3678 32 COG3744 COG3744, Uncharacterized protein conserved in bacteria Function unknown 167648974 Common - transcription termination factor Rho Caul_5019 205 COG1158 Rho, Transcription termination factor Transcription 167648276 Common - protein of unknown function DUF1508 Caul_4321 9 COG3422 COG3422, Uncharacterized conserved protein Function unknown 167644469 Common - Alcohol dehydrogenase zinc-binding domain protein Caul_0500 160 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 167648653 Common - TonB-dependent receptor Caul_4698 98 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167646459 Common - Pyrrolo-quinoline quinone Caul_2497 112 COG1520 COG1520, FOG: WD40-like repeat Function unknown 167646662 Common - rare lipoprotein A Caul_2700 137 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 167648228 Common - peptidase M28 Caul_4272 49 COG2234 Iap, Predicted aminopeptidases General function prediction only 167647339 Common - methyltransferase small Caul_3377 54 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 167644020 Common - General substrate transporter Caul_0047 142 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167644400 Common - Alcohol dehydrogenase zinc-binding domain protein Caul_0428 126 COG2130 COG2130, Putative NADP-dependent oxidoreductases General function prediction only 167645789 Nonpathogen - hypothetical protein Caul_1825 1 None None None 167647395 Common - hypothetical protein Caul_3433 5 None None None 167647826 Common - nitrate reductase, beta subunit Caul_3865 151 COG1140 NarY, Nitrate reductase beta subunit Energy production and conversion 167648084 Common - Amidohydrolase 3 Caul_4125 113 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 167645155 Common - phenylalanyl-tRNA synthetase, alpha subunit Caul_1190 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 167644423 Common - hypothetical protein Caul_0451 7 COG3553 COG3553, Uncharacterized protein conserved in bacteria Function unknown 167646992 Nonpathogen - hypothetical protein Caul_3030 1 None None None 167646244 Common - stress protein Caul_2282 14 COG2310 TerZ, Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 Signal transduction mechanisms 167646737 Nonpathogen - hypothetical protein Caul_2775 1 None None None 167647647 Common - response regulator receiver protein Caul_3685 56 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 167647694 Nonpathogen - transcriptional repressor, CopY family Caul_3732 7 COG3682 COG3682, Predicted transcriptional regulator Transcription 167644230 Common - Orn/DAP/Arg decarboxylase 2 Caul_0258 121 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 167646878 Common - thiolase family protein Caul_2916 107 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167647289 Common - major facilitator superfamily MFS_1 Caul_3327 212 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167646551 Nonpathogen - hypothetical protein Caul_2589 1 None None None 167646596 Common - N-formylglutamate amidohydrolase Caul_2634 37 COG3931 COG3931, Predicted N-formylglutamate amidohydrolase Amino acid transport and metabolism 167645644 Nonpathogen - hypothetical protein Caul_1680 8 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 167645472 Common - protein of unknown function DUF497 Caul_1507 26 COG2929 COG2929, Uncharacterized protein conserved in bacteria Function unknown 167645222 Nonpathogen - hypothetical protein Caul_1257 1 None None None 167648496 Common - Three-deoxy-D-manno-octulosonic-acid transferase domain protein Caul_4541 128 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 167643978 Nonpathogen - hypothetical protein Caul_0005 1 None None None 167646441 Common - hypothetical protein Caul_2479 22 None None None 167648310 Common - transposase IS116/IS110/IS902 family protein Caul_4355 63 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 167648522 Common - tRNA pseudouridine synthase A Caul_4567 235 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 167644043 Common - Carbonate dehydratase Caul_0070 135 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 167646659 Common - hydrolase, TatD family Caul_2697 237 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 167644629 Common - response regulator receiver protein Caul_0661 120 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 167646553 Common - FeS assembly ATPase SufC Caul_2591 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 167648743 Common - protein of unknown function UPF0118 Caul_4788 101 COG0628 PerM, Predicted permease General function prediction only 167646410 Nonpathogen - hypothetical protein Caul_2448 1 None None None 167648846 Common - Palmitoyl-CoA hydrolase Caul_4891 77 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 167644937 Common - hypothetical protein Caul_0972 12 None None None 167648481 Common - protein of unknown function DUF37 Caul_4526 182 COG0759 COG0759, Uncharacterized conserved protein Function unknown 167648576 Common - beta-lactamase Caul_4621 73 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 167647816 Common - molybdenum cofactor biosynthesis protein B Caul_3855 185 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 167646558 Nonpathogen - hypothetical protein Caul_2596 2 None None None 167644551 Common - Citrate transporter Caul_0583 35 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 167644207 Common - dihydrolipoamide dehydrogenase Caul_0235 242 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 167648815 Common - signal recognition particle-docking protein FtsY Caul_4860 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 167644865 Common - hypothetical protein Caul_0899 21 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167647658 Common - protein of unknown function DUF1223 Caul_3696 33 COG5429 COG5429, Uncharacterized secreted protein Function unknown 167644176 Nonpathogen - membrane-associated protein in eicosanoid and glutathione metabolism (MAPEG) Caul_0204 10 COG3788 COG3788, Uncharacterized relative of glutathione S-transferase, MAPEG superfamily General function prediction only 167647206 Common - Aldehyde Dehydrogenase_ Caul_3244 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167647993 Common - NmrA family protein Caul_4033 133 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167647317 Nonpathogen - hypothetical protein Caul_3355 2 None None None 167648833 Common - hypothetical protein Caul_4878 22 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 167645876 Common - cytochrome P450 Caul_1912 78 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 167644447 Common - hypothetical protein Caul_0478 11 None None None 167648090 Nonpathogen - hypothetical protein Caul_4131 1 None None None 167644237 Common - putative aspartyl protease Caul_0265 46 COG3577 COG3577, Predicted aspartyl protease General function prediction only 167646976 Common - fructose-1,6-bisphosphatase, class II Caul_3014 112 COG1494 GlpX, Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins Carbohydrate transport and metabolism 167644886 Common - transcriptional regulator, ArsR family Caul_0920 36 COG0640 ArsR, Predicted transcriptional regulators Transcription 167647367 Common - PilT-like protein Caul_3405 31 COG5573 COG5573, Predicted nucleic-acid-binding protein, contains PIN domain General function prediction only 167647543 Common - MotA/TolQ/ExbB proton channel Caul_3581 148 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 167644343 Common - protein of unknown function DUF418 Caul_0371 43 COG2311 COG2311, Predicted membrane protein Function unknown 167645659 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Caul_1695 137 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 167644190 Common - tRNA (guanine-N1)-methyltransferase Caul_0218 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 167644131 Common - short-chain dehydrogenase/reductase SDR Caul_0159 237 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 167645628 Nonpathogen - hypothetical protein Caul_1664 1 None None None 167645117 Common - Ti-type conjugative transfer relaxase TraA Caul_1152 130 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 167646821 Common - TonB-dependent receptor Caul_2859 60 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 167647090 Nonpathogen - hypothetical protein Caul_3128 1 None None None 167644321 Common - Lysine exporter protein (LYSE/YGGA) Caul_0349 102 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 167644112 Common - hypothetical protein Caul_0139 11 None None None 167648941 Common - hypothetical protein Caul_4986 26 None None None 167647031 Nonpathogen - hypothetical protein Caul_3069 1 None None None 167647190 Common - histidinol-phosphate aminotransferase Caul_3228 230 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 167644110 Common - lysyl-tRNA synthetase Caul_0137 77 COG1384 LysS, Lysyl-tRNA synthetase (class I) Translation, ribosomal structure and biogenesis 167643991 Common - nitroreductase Caul_0018 63 COG0778 NfnB, Nitroreductase Energy production and conversion 167645283 Common - protein of unknown function DUF442 Caul_1318 39 COG3453 COG3453, Uncharacterized protein conserved in bacteria Function unknown 167648162 Common - protein tyrosine/serine phosphatase Caul_4203 46 COG2365 COG2365, Protein tyrosine/serine phosphatase Signal transduction mechanisms 167648153 Common - Flp pilus assembly protein CpaB Caul_4194 57 COG3745 CpaB, Flp pilus assembly protein CpaB Intracellular trafficking and secretion 167644718 Common - bacterioferritin Caul_0752 104 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 167647590 Common - 2-nitropropane dioxygenase NPD Caul_3628 122 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 167644847 Nonpathogen - hypothetical protein Caul_0881 1 None None None 167647996 Common - 3-hydroxybutyryl-CoA dehydrogenase Caul_4036 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 167647480 Nonpathogen - hypothetical protein Caul_3518 1 None None None 167646762 Common - phosphatidate cytidylyltransferase Caul_2800 211 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 167646908 Common - aminotransferase class-III Caul_2946 206 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 167644997 Common - Integrase catalytic region Caul_1032 146 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 167648209 Common - excinuclease ABC, B subunit Caul_4253 228 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 167647022 Common - 6-phosphogluconate dehydrogenase NAD-binding Caul_3060 196 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 167644411 Common - transcriptional regulator, TetR family Caul_0439 43 COG1309 AcrR, Transcriptional regulator Transcription 167646120 Common - (Uracil-5)-methyltransferase Caul_2157 193 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 167646901 Common - ABC-1 domain protein Caul_2939 184 COG0661 AarF, Predicted unusual protein kinase General function prediction only 167647429 Nonpathogen - hypothetical protein Caul_3467 1 None None None 167644948 Common - ribonuclease BN Caul_0983 145 COG1295 Rbn, Predicted membrane protein Function unknown 167645769 Common - Aldose 1-epimerase Caul_1805 93 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 167647401 Common - adenylosuccinate lyase Caul_3439 240 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 167648249 Common - protein of unknown function DUF1022 Caul_4294 21 COG3660 COG3660, Predicted nucleoside-diphosphate-sugar epimerase Cell envelope biogenesis, outer membrane 167645130 Common - hypothetical protein Caul_1165 16 COG2315 MmcQ, Uncharacterized protein conserved in bacteria Function unknown 167645415 Common - Peptidoglycan-binding domain 1 protein Caul_1450 88 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 167646507 Common - phosphoribosylformylglycinamidine cyclo-ligase Caul_2545 230 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 167644928 Common - Alpha/beta hydrolase fold-3 domain protein Caul_0963 110 COG0657 Aes, Esterase/lipase Lipid metabolism 167647898 Nonpathogen - hypothetical protein Caul_3938 1 None None None 167647565 Nonpathogen - hypothetical protein Caul_3603 1 None None None 167647097 Common - ATP-dependent Clp protease adaptor protein ClpS Caul_3135 118 COG2127 COG2127, Uncharacterized conserved protein Function unknown 167648519 Common - Glutaminase Caul_4564 72 COG2066 GlsA, Glutaminase Amino acid transport and metabolism 167644990 Common - response regulator receiver protein Caul_1025 10 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 167646809 Common - HAD-superfamily subfamily IB hydrolase, TIGR01490 Caul_2847 29 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 167645356 Common - diguanylate phosphodiesterase Caul_1391 161 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 167645959 Nonpathogen - transcriptional regulator Caul_1996 3 None None None 167644510 Common - monooxygenase FAD-binding Caul_0541 93 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 167644275 Common - alpha amylase catalytic region Caul_0303 160 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 167644516 Common - short-chain dehydrogenase/reductase SDR Caul_0547 225 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 167645848 Common - amidohydrolase 2 Caul_1884 23 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 167644195 Common - response regulator receiver protein Caul_0223 13 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 167645095 Common - N-acyl-D-glutamate deacylase Caul_1130 59 COG3653 COG3653, N-acyl-D-aspartate/D-glutamate deacylase Secondary metabolites biosynthesis, transport, and catabolism 167646774 Common - prolyl-tRNA synthetase Caul_2812 248 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 167644613 Common - Alpha/beta hydrolase fold-3 domain protein Caul_0645 127 COG0657 Aes, Esterase/lipase Lipid metabolism 167647431 Nonpathogen - hypothetical protein Caul_3469 1 None None None 167648696 Common - ATP synthase F1, delta subunit Caul_4741 175 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 167648405 Common - allophanate hydrolase Caul_4450 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 167647806 Common - transcriptional regulator, AraC family Caul_3845 81 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 167648167 Common - protein of unknown function DUF1052 Caul_4208 30 COG5321 COG5321, Uncharacterized protein conserved in bacteria Function unknown 167644532 Common - transcriptional regulator, AraC family Caul_0564 138 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 167647520 Common - sodium/hydrogen exchanger Caul_3558 138 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 167648861 Nonpathogen - putative addiction module antidote protein, CopG/Arc/MetJ family Caul_4906 2 COG3609 COG3609, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain Transcription 167646855 Nonpathogen - hypothetical protein Caul_2893 1 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 167646381 Nonpathogen - cytochrome B561 Caul_2419 2 COG3658 COG3658, Cytochrome b Energy production and conversion 167648457 Common - cytochrome c oxidase assembly protein CtaG/Cox11 Caul_4502 68 COG3175 COX11, Cytochrome oxidase assembly factor Posttranslational modification, protein turnover, chaperones 167648371 Nonpathogen - hypothetical protein Caul_4416 1 None None None 167645101 Common - TonB-dependent receptor Caul_1136 92 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647981 Common - glycoside hydrolase family 43 Caul_4021 43 COG3507 XynB, Beta-xylosidase Carbohydrate transport and metabolism 167648493 Common - ABC transporter related Caul_4538 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 167645212 Nonpathogen - hypothetical protein Caul_1247 2 None None None 167648108 Nonpathogen - hypothetical protein Caul_4149 1 None None None 167647462 Common - hypothetical protein Caul_3500 7 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 167646630 Common - flavin reductase domain protein FMN-binding Caul_2668 56 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 167647130 Nonpathogen - hypothetical protein Caul_3168 1 None None None 167648271 Common - glutathione S-transferase-like protein Caul_4316 16 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167646935 Common - magnesium-translocating P-type ATPase Caul_2973 232 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 167646428 Nonpathogen - cytochrome c class I Caul_2466 2 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 167649023 Common - GreA/GreB family elongation factor Caul_5068 53 COG0782 GreA, Transcription elongation factor Transcription 167645401 Common - hypothetical protein Caul_1436 22 COG3334 COG3334, Uncharacterized conserved protein Function unknown 167647948 Common - PepSY-associated TM helix domain protein Caul_3988 27 COG3295 COG3295, Uncharacterized protein conserved in bacteria Function unknown 167644839 Common - ribosomal protein L36 Caul_0873 23 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 167644808 Common - protein of unknown function DUF450 Caul_0842 33 COG4748 COG4748, Uncharacterized conserved protein Function unknown 167645263 Common - imidazolonepropionase Caul_1298 103 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 167648331 Nonpathogen - putative ATP synthase protein I Caul_4376 1 COG5336 COG5336, Uncharacterized protein conserved in bacteria Function unknown 167644694 Common - 3-demethylubiquinone-9 3-methyltransferase Caul_0726 66 COG3865 COG3865, Uncharacterized protein conserved in bacteria Function unknown 167646719 Common - pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase Caul_2757 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 167646896 Nonpathogen - hypothetical protein Caul_2934 1 None None None 167648059 Common - TonB-dependent receptor Caul_4100 107 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 167648948 Common - protein of unknown function UPF0005 Caul_4993 133 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 167645994 Common - P-type conjugative transfer protein TrbJ Caul_2031 22 COG5314 COG5314, Conjugal transfer/entry exclusion protein Intracellular trafficking and secretion 167645965 Common - Integrase catalytic region Caul_2002 147 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 167647385 Common - Sel1 domain protein repeat-containing protein Caul_3423 40 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 167645621 Common - CrcB protein Caul_1657 78 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 167647139 Common - protein of unknown function zinc metallopeptidase putative Caul_3177 87 COG2321 COG2321, Predicted metalloprotease General function prediction only 167645729 Common - oxidoreductase domain protein Caul_1765 99 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 167648824 Common - Ion transport 2 domain protein Caul_4869 36 None None None 167646106 Common - tryptophan halogenase Caul_2143 16 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 167646227 Common - hypothetical protein Caul_2265 9 None None None 167645319 Common - hypothetical protein Caul_1354 4 None None None 167647444 Nonpathogen - hypothetical protein Caul_3482 1 None None None 167646828 Nonpathogen - proteinase inhibitor I1 Kazal Caul_2866 8 None None None 167646862 Nonpathogen - hypothetical protein Caul_2900 3 None None None 167647047 Common - SsrA-binding protein Caul_3085 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 167648250 Nonpathogen - hypothetical protein Caul_4295 1 None None None 167649031 Common - NAD-dependent epimerase/dehydratase Caul_5076 91 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167644003 Common - protein of unknown function DUF150 Caul_0030 178 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 167648793 Common - succinate dehydrogenase, flavoprotein subunit Caul_4838 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 167647261 Common - CheC, inhibitor of MCP methylation Caul_3299 22 COG1776 CheC, Chemotaxis protein CheC, inhibitor of MCP methylation Cell motility and secretion / Signal transduction mechanisms 167644984 Nonpathogen - hypothetical protein Caul_1019 1 None None None 167647863 Common - hypothetical protein Caul_3903 21 COG5449 COG5449, Uncharacterized conserved protein Function unknown 167645241 Common - protein of unknown function DUF214 Caul_1276 71 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 167648097 Nonpathogen - hypothetical protein Caul_4138 2 None None None 167648230 Common - hypothetical protein Caul_4274 17 None None None 167648553 Common - glucosamine--fructose-6-phosphate aminotransferase, isomerizing Caul_4598 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 167646374 Common - Alpha-galactosidase Caul_2412 18 COG3345 GalA, Alpha-galactosidase Carbohydrate transport and metabolism 167645819 Common - sulfotransferase Caul_1855 143 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 167644438 Nonpathogen - DNA binding domain protein, excisionase family Caul_0469 1 None None None 167648319 Common - DNA-3-methyladenine glycosylase I Caul_4364 132 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 167645540 Common - toluene tolerance family protein Caul_1575 23 COG2854 Ttg2D, ABC-type transport system involved in resistance to organic solvents, auxiliary component Secondary metabolites biosynthesis, transport, and catabolism 167645873 Common - 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase Caul_1909 174 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 167644302 Nonpathogen - hypothetical protein Caul_0330 5 None None None 167645442 Nonpathogen - hypothetical protein Caul_1477 1 None None None 167646614 Nonpathogen - hypothetical protein Caul_2652 1 None None None 167644707 Common - NADH:flavin oxidoreductase/NADH oxidase Caul_0741 177 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 167645166 Nonpathogen - hypothetical protein Caul_1201 6 None None None 167644299 Nonpathogen - putative conjugal transfert protein, TraC Caul_0327 9 None None None 167648689 Common - CBS domain containing membrane protein Caul_4734 58 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 167646526 Common - acetyl-CoA carboxylase, biotin carboxylase Caul_2564 237 COG0439 AccC, Biotin carboxylase Lipid metabolism 167647650 Nonpathogen - FliX protein Caul_3688 8 None None None 167648101 Nonpathogen - hypothetical protein Caul_4142 1 None None None 167645810 Common - polysaccharide deacetylase Caul_1846 9 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 167647245 Common - Esterase/lipase-like protein Caul_3283 110 COG0657 Aes, Esterase/lipase Lipid metabolism 167644652 Common - Enoyl-CoA hydratase/isomerase Caul_0684 142 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 167648416 Common - DNA polymerase III, alpha subunit Caul_4461 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 167648591 Common - CMP/dCMP deaminase zinc-binding Caul_4636 211 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 167644716 Common - thiamine-phosphate pyrophosphorylase Caul_0750 174 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 167648586 Nonpathogen - hypothetical protein Caul_4631 3 None None None 167648856 Nonpathogen - hypothetical protein Caul_4901 1 None None None 167648882 Nonpathogen - hypothetical protein Caul_4927 2 None None None 167644455 Common - hypothetical protein Caul_0486 26 None None None 167645128 Common - protein of unknown function DUF437 Caul_1163 24 COG4933 COG4933, Uncharacterized conserved protein Function unknown 167647524 Nonpathogen - hypothetical protein Caul_3562 1 None None None 167644150 Common - glutathione synthetase Caul_0178 121 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 167647238 Common - Carbohydrate binding family 6 Caul_3276 30 COG3507 XynB, Beta-xylosidase Carbohydrate transport and metabolism 167645121 Common - protein of unknown function DUF955 Caul_1156 11 COG2856 COG2856, Predicted Zn peptidase Amino acid transport and metabolism 167647163 Common - HNH endonuclease Caul_3201 102 COG1403 McrA, Restriction endonuclease Defense mechanisms 167647936 Nonpathogen - hypothetical protein Caul_3976 1 None None None 167647672 Common - transcriptional regulator, TetR family Caul_3710 77 COG1309 AcrR, Transcriptional regulator Transcription 167646528 Common - 3-dehydroquinate dehydratase Caul_2566 170 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 167647237 Common - transposase IS3/IS911 family protein Caul_3275 44 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646627 Common - Rhodanese domain protein Caul_2665 38 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 167647232 Common - transcriptional regulator, LysR family Caul_3270 163 COG0583 LysR, Transcriptional regulator Transcription 167648825 Common - Prolyl oligopeptidase Caul_4870 110 COG1505 COG1505, Serine proteases of the peptidase family S9A Amino acid transport and metabolism 167644952 Common - protein-(glutamine-N5) methyltransferase, release factor-specific Caul_0987 225 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 167645393 Nonpathogen - hypothetical protein Caul_1428 1 None None None 167644785 Common - transcriptional regulator, AsnC family Caul_0819 154 COG1522 Lrp, Transcriptional regulators Transcription 167644439 Common - response regulator receiver protein Caul_0470 41 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 167647303 Common - short-chain dehydrogenase/reductase SDR Caul_3341 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167648737 Common - phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Caul_4782 218 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 167647648 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Caul_3686 49 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 167648875 Common - NAD-dependent epimerase/dehydratase Caul_4920 232 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167645320 Common - methyl-accepting chemotaxis sensory transducer Caul_1355 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 167644205 Common - SpoVT/AbrB domain protein Caul_0233 15 COG4456 VagC, Virulence-associated protein and related proteins Function unknown 167644115 Common - anti-FecI sigma factor, FecR Caul_0142 44 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 167644977 Common - flagellar M-ring protein FliF Caul_1012 125 COG1766 FliF, Flagellar biosynthesis/type III secretory pathway lipoprotein Cell motility and secretion / Intracellular trafficking and secretion 167645716 Common - sugar transferase Caul_1752 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 167649019 Common - short-chain dehydrogenase/reductase SDR Caul_5064 215 COG0623 FabI, Enoyl- acyl-carrier-protein 167648485 Common - GTP cyclohydrolase I Caul_4530 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 167648063 Nonpathogen - hypothetical protein Caul_4104 11 COG4731 COG4731, Uncharacterized protein conserved in bacteria Function unknown 167647124 Nonpathogen - protein of unknown function DUF805 Caul_3162 5 COG3152 COG3152, Predicted membrane protein Function unknown 167644162 Common - major facilitator superfamily MFS_1 Caul_0190 102 None None None 167647061 Common - DNA repair protein RecN Caul_3099 188 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 167646162 Common - surface antigen (D15) Caul_2199 136 COG0729 COG0729, Outer membrane protein Cell envelope biogenesis, outer membrane 167648917 Nonpathogen - protein of unknown function DUF1150 Caul_4962 2 COG5568 COG5568, Uncharacterized small protein Function unknown 167647873 Common - phage major capsid protein, HK97 family Caul_3913 50 COG4653 COG4653, Predicted phage phi-C31 gp36 major capsid-like protein General function prediction only 167645902 Common - major facilitator superfamily MFS_1 Caul_1938 222 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 167646724 Common - Phosphopyruvate hydratase Caul_2762 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 167645324 Common - protein of unknown function DUF1457 Caul_1359 9 COG5388 COG5388, Uncharacterized protein conserved in bacteria Function unknown 167648106 Nonpathogen - hypothetical protein Caul_4147 1 None None None 167648526 Common - protein of unknown function DUF195 Caul_4571 108 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 167645887 Common - short-chain dehydrogenase/reductase SDR Caul_1923 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167648585 Common - two component transcriptional regulator, winged helix family Caul_4630 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167647259 Common - signal transduction histidine kinase Caul_3297 91 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 167645009 Common - delta-1-pyrroline-5-carboxylate dehydrogenase Caul_1044 219 COG4230 COG4230, Delta 1-pyrroline-5-carboxylate dehydrogenase Energy production and conversion 167645144 Common - protein of unknown function DUF86 Caul_1179 23 COG2361 COG2361, Uncharacterized conserved protein Function unknown 167646560 Common - transcriptional regulator, TetR family Caul_2598 22 COG1309 AcrR, Transcriptional regulator Transcription 167644912 Nonpathogen - hypothetical protein Caul_0946 2 None None None 167648259 Common - thioredoxin reductase Caul_4304 245 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 167645553 Common - beta-lactamase domain protein Caul_1588 217 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 167644966 Common - acetyl-CoA acetyltransferase Caul_1001 186 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167644139 Common - ribonuclease PH Caul_0167 179 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 167646544 Common - protein of unknown function UPF0075 Caul_2582 120 COG2377 COG2377, Predicted molecular chaperone distantly related to HSP70-fold metalloproteases Posttranslational modification, protein turnover, chaperones 167644970 Common - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Caul_1005 216 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 167645164 Common - alpha/beta hydrolase fold Caul_1199 69 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167645034 Nonpathogen - hypothetical protein Caul_1069 1 None None None 167648118 Common - putative transposase Caul_4159 102 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 167644509 Common - transcriptional regulator, MarR family Caul_0540 17 COG1846 MarR, Transcriptional regulators Transcription 167644521 Common - IstB domain protein ATP-binding protein Caul_0553 92 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 167644814 Common - Extensin family protein Caul_0848 37 COG3921 COG3921, Uncharacterized protein conserved in bacteria Function unknown 167646953 Common - Aspartyl/Asparaginyl beta-hydroxylase Caul_2991 11 COG3555 COG3555, Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases Posttranslational modification, protein turnover, chaperones 167646225 Nonpathogen - hypothetical protein Caul_2263 1 None None None 167648688 Nonpathogen - hypothetical protein Caul_4733 1 COG5373 COG5373, Predicted membrane protein Function unknown 167648774 Common - polysaccharide export protein Caul_4819 103 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 167645569 Nonpathogen - hypothetical protein Caul_1605 1 None None None 167647185 Common - ChaC family protein Caul_3223 44 COG3703 ChaC, Uncharacterized protein involved in cation transport Inorganic ion transport and metabolism 167647854 Nonpathogen - hypothetical protein Caul_3894 2 None None None 167647711 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Caul_3749 21 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 167648744 Common - protein of unknown function DUF853 NPT hydrolase putative Caul_4789 76 COG0433 COG0433, Predicted ATPase General function prediction only 167645478 Nonpathogen - hypothetical protein Caul_1513 1 None None None 167647493 Common - Ethanolamine ammonia lyase large subunit Caul_3531 55 COG4303 EutB, Ethanolamine ammonia-lyase, large subunit Amino acid transport and metabolism 167647938 Common - signal transduction histidine kinase Caul_3978 39 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 167645002 Common - carbamoyl-phosphate synthase, small subunit Caul_1037 235 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 167646430 Nonpathogen - cytochrome c class I Caul_2468 9 COG2863 COG2863, Cytochrome c553 Energy production and conversion 167646211 Common - hypothetical protein Caul_2249 23 None None None 167645828 Common - hypothetical protein Caul_1864 50 COG3781 COG3781, Predicted membrane protein Function unknown 167644793 Nonpathogen - hypothetical protein Caul_0827 1 None None None 167648345 Nonpathogen - hypothetical protein Caul_4390 6 None None None 167648888 Common - histidinol-phosphate phosphatase family protein Caul_4933 189 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 167644519 Common - transcriptional regulator, TetR family Caul_0550 73 COG1309 AcrR, Transcriptional regulator Transcription 167645347 Common - flagellar biosynthetic protein FliQ Caul_1382 10 COG1987 FliQ, Flagellar biosynthesis pathway, component FliQ Cell motility and secretion / Intracellular trafficking and secretion 167644405 Nonpathogen - hypothetical protein Caul_0433 1 None None None 167648007 Common - transcriptional regulator, TetR family Caul_4047 86 COG1309 AcrR, Transcriptional regulator Transcription 167648184 Common - hypothetical protein Caul_4227 5 None None None 167644605 Common - CheW protein Caul_0637 136 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 167644187 Common - 3-isopropylmalate dehydratase, small subunit Caul_0215 211 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 167648637 Common - hypothetical protein Caul_4682 5 None None None 167647292 Common - Uracil-DNA glycosylase superfamily Caul_3330 59 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 167647563 Common - hypothetical protein Caul_3601 21 None None None 167644449 Nonpathogen - nuclease (SNase domain protein) Caul_0480 2 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 167647862 Common - phage cell wall peptidase, NlpC/P60 family Caul_3902 18 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 167645600 Common - ribosomal protein S13 Caul_1636 245 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 167647913 Common - aminotransferase class-III Caul_3953 236 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 167645931 Common - TonB-dependent receptor plug Caul_1967 70 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167645946 Nonpathogen - transcriptional regulator, GntR family Caul_1983 6 COG1802 GntR, Transcriptional regulators Transcription 167646657 Common - osmosensitive K+ channel signal transduction histidine kinase Caul_2695 220 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 167646830 Common - transcriptional regulator, TetR family Caul_2868 41 COG1309 AcrR, Transcriptional regulator Transcription 167648147 Common - type II secretion system protein Caul_4188 65 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion 167644746 Common - protein of unknown function DUF28 Caul_0780 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 167646624 Common - extracellular solute-binding protein family 3 Caul_2662 83 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 167647817 Common - molybdenum cofactor synthesis domain protein Caul_3856 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 167648679 Common - carboxyl-terminal protease Caul_4724 182 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 167644247 Nonpathogen - hypothetical protein Caul_0275 1 None None None 167647535 Common - L-carnitine dehydratase/bile acid-inducible protein F Caul_3573 115 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 167648013 Nonpathogen - hypothetical protein Caul_4053 1 None None None 167647101 Common - histidine triad (HIT) protein Caul_3139 235 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 167648140 Common - hypothetical protein Caul_4181 5 None None None 167645094 Common - transcriptional regulator, AsnC family Caul_1129 115 COG1522 Lrp, Transcriptional regulators Transcription 167647142 Common - pyridoxal phosphate-dependent enzyme, D-cysteine desulfhydrase family Caul_3180 78 COG2515 Acd, 1-aminocyclopropane-1-carboxylate deaminase Amino acid transport and metabolism 167645836 Common - catalytic domain of components of various dehydrogenase complexes Caul_1872 194 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 167647700 Common - oligopeptide transporter, OPT family Caul_3738 41 COG1297 COG1297, Predicted membrane protein Function unknown 167648719 Nonpathogen - hypothetical protein Caul_4764 1 None None None 167646999 Common - SmpA/OmlA domain protein Caul_3037 36 COG2913 SmpA, Small protein A (tmRNA-binding) Translation, ribosomal structure and biogenesis 167647553 Nonpathogen - hypothetical protein Caul_3591 1 None None None 167647284 Common - Protein of unknown function DUF1810 Caul_3322 28 COG5579 COG5579, Uncharacterized conserved protein Function unknown 167647229 Common - nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein Caul_3267 171 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 167645384 Nonpathogen - hypothetical protein Caul_1419 1 None None None 167647408 Common - cytochrome P450 Caul_3446 82 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 167644031 Common - molybdopterin biosynthesis MoaE protein Caul_0058 154 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 167648617 Common - OmpA/MotB domain protein Caul_4662 69 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 167646986 Common - N-acetyl-gamma-glutamyl-phosphate reductase Caul_3024 214 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 167647754 Common - methionine aminopeptidase, type I Caul_3793 236 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 167644290 Common - sugar isomerase (SIS) Caul_0318 37 COG2222 AgaS, Predicted phosphosugar isomerases Cell envelope biogenesis, outer membrane 167647579 Common - Aldehyde Dehydrogenase_ Caul_3617 169 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167645632 Common - GumN family protein Caul_1668 55 COG3735 COG3735, Uncharacterized protein conserved in bacteria Function unknown 167646692 Common - hypothetical protein Caul_2730 5 None None None 167647319 Common - transcriptional regulator, AraC family Caul_3357 116 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 167647159 Common - hypothetical protein Caul_3197 33 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 167645669 Common - carboxyl transferase Caul_1705 210 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 167644087 Common - Rieske (2Fe-2S) domain protein Caul_0114 27 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 167645454 Common - cell shape determining protein, MreB/Mrl family Caul_1489 223 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 167646961 Common - carboxyl transferase Caul_2999 210 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 167647598 Common - protein of unknown function DUF74 Caul_3636 96 COG0393 COG0393, Uncharacterized conserved protein Function unknown 167648474 Common - acetyl-CoA acetyltransferase Caul_4519 176 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167647514 Common - hypothetical protein Caul_3552 70 COG0657 Aes, Esterase/lipase Lipid metabolism 167648565 Common - oxidoreductase domain protein Caul_4610 165 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 167648675 Nonpathogen - hypothetical protein Caul_4720 1 None None None 167648261 Common - Ferritin Dps family protein Caul_4306 106 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 167648986 Common - hypothetical protein Caul_5031 23 None None None 167644738 Common - transcriptional regulator, MarR family Caul_0772 39 COG1846 MarR, Transcriptional regulators Transcription 167644335 Common - hypothetical protein Caul_0363 34 COG3897 COG3897, Predicted methyltransferase General function prediction only 167644397 Common - 2-nitropropane dioxygenase NPD Caul_0425 45 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 167644214 Common - Integral membrane protein TerC Caul_0242 113 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 167648985 Common - leucyl-tRNA synthetase Caul_5030 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 167644642 Common - prolipoprotein diacylglyceryl transferase Caul_0674 204 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 167645252 Common - 2-dehydro-3-deoxygalactonokinase Caul_1287 38 COG3734 DgoK, 2-keto-3-deoxy-galactonokinase Carbohydrate transport and metabolism 167644888 Common - preprotein translocase, SecA subunit Caul_0922 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 167645662 Common - hypothetical protein Caul_1698 8 None None None 167644487 Common - L-serine dehydratase 1 Caul_0518 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 167645056 Common - magnesium and cobalt transport protein CorA Caul_1091 165 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 167647749 Nonpathogen - hypothetical protein Caul_3787 2 None None None 167647614 Common - homogentisate 1,2-dioxygenase Caul_3652 52 COG3508 HmgA, Homogentisate 1,2-dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 167645588 Common - ribosomal protein L14 Caul_1624 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 167648780 Common - NAD-dependent epimerase/dehydratase Caul_4825 232 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167645471 Common - transcriptional regulator, XRE family Caul_1506 25 COG2944 COG2944, Predicted transcriptional regulator Transcription 167648353 Common - hypothetical protein Caul_4398 18 COG4520 LipA, Surface antigen Cell envelope biogenesis, outer membrane 167646968 Common - peptidase U32 Caul_3006 47 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 167648313 Common - proline iminopeptidase Caul_4358 111 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167644949 Common - MOSC domain containing protein Caul_0984 54 COG3217 COG3217, Uncharacterized Fe-S protein General function prediction only 167646573 Common - GTP-binding proten HflX Caul_2611 225 COG2262 HflX, GTPases General function prediction only 167647455 Nonpathogen - hypothetical protein Caul_3493 1 None None None 167644012 Common - tRNA pseudouridine synthase B Caul_0039 245 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 167644105 Common - transcriptional regulator, MerR family Caul_0132 85 COG0789 SoxR, Predicted transcriptional regulators Transcription 167644179 Common - short-chain dehydrogenase/reductase SDR Caul_0207 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167647131 Nonpathogen - hypothetical protein Caul_3169 1 None None None 167644154 Common - 2OG-Fe(II) oxygenase Caul_0182 54 COG3491 PcbC, Isopenicillin N synthase and related dioxygenases General function prediction only 167645443 Nonpathogen - hypothetical protein Caul_1478 2 None None None 167647032 Common - protein of unknown function DUF188 Caul_3070 92 COG1671 COG1671, Uncharacterized protein conserved in bacteria Function unknown 167645426 Nonpathogen - hypothetical protein Caul_1461 1 None None None 167648277 Common - short-chain dehydrogenase/reductase SDR Caul_4322 236 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 167646532 Common - DSBA oxidoreductase Caul_2570 94 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 167648751 Common - UbiA prenyltransferase Caul_4796 66 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 167648786 Common - peptidase T2 asparaginase 2 Caul_4831 84 COG1446 COG1446, Asparaginase Amino acid transport and metabolism 167646501 Common - integral membrane sensor signal transduction histidine kinase Caul_2539 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167644731 Common - fructose-bisphosphate aldolase, class II, Calvin cycle subtype Caul_0765 174 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 167647619 Common - cell division protein FtsZ Caul_3657 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 167644184 Common - AMP-dependent synthetase and ligase Caul_0212 221 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167645673 Common - ABC-2 type transporter Caul_1709 38 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 167648710 Nonpathogen - hypothetical protein Caul_4755 3 COG3650 COG3650, Predicted membrane protein Function unknown 167647924 Nonpathogen - hypothetical protein Caul_3964 1 None None None 167646941 Common - ABC transporter related Caul_2979 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 167648610 Common - Hemolysin-type calcium-binding region Caul_4655 80 COG2931 COG2931, RTX toxins and related Ca2+-binding proteins Secondary metabolites biosynthesis, transport, and catabolism 167644193 Common - DNA polymerase I Caul_0221 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 167645041 Common - catalase/peroxidase HPI Caul_1076 98 COG0376 KatG, Catalase (peroxidase I) Inorganic ion transport and metabolism 167644389 Common - cyclase family protein Caul_0417 57 COG1878 COG1878, Predicted metal-dependent hydrolase General function prediction only 167647714 Common - serine O-acetyltransferase Caul_3752 192 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 167644070 Common - hypothetical protein Caul_0097 29 COG5385 COG5385, Uncharacterized protein conserved in bacteria Function unknown 167644568 Common - hypothetical protein Caul_0600 2 None None None 167646005 Common - integrase family protein Caul_2042 57 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 167644563 Common - protein tyrosine phosphatase-like protein Caul_0595 16 COG5350 COG5350, Predicted protein tyrosine phosphatase General function prediction only 167647313 Common - acetolactate synthase, large subunit, biosynthetic type Caul_3351 222 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 167646672 Common - transcriptional regulator, TetR family Caul_2710 63 COG1309 AcrR, Transcriptional regulator Transcription 167646915 Common - uroporphyrin-III C-methyltransferase Caul_2953 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 167644764 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Caul_0798 41 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 167644708 Common - Threonine aldolase Caul_0742 91 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 167644274 Nonpathogen - hypothetical protein Caul_0302 1 None None None 167644772 Common - acriflavin resistance protein Caul_0806 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 167645136 Common - Glutaryl-7-aminocephalosporanic-acid acylase Caul_1171 76 COG2366 COG2366, Protein related to penicillin acylase General function prediction only 167645460 Nonpathogen - hypothetical protein Caul_1495 8 None None None 167647215 Common - MATE efflux family protein Caul_3253 106 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 167644019 Common - PAS/PAC sensor hybrid histidine kinase Caul_0046 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167644157 Common - radical SAM enzyme, Cfr family Caul_0185 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 167645071 Common - putative transposase of insertion sequence ISRm2011-2, orfA protein Caul_1106 20 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646375 Common - glycoside hydrolase family 43 Caul_2413 40 COG3507 XynB, Beta-xylosidase Carbohydrate transport and metabolism 167646759 Common - outer membrane protein assembly complex, YaeT protein Caul_2797 158 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 167645490 Nonpathogen - hypothetical protein Caul_1525 1 COG5455 COG5455, Predicted integral membrane protein Function unknown 167648722 Nonpathogen - hypothetical protein Caul_4767 2 None None None 167646042 Common - polysaccharide export protein Caul_2079 72 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 167648779 Common - nucleotide sugar dehydrogenase Caul_4824 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 167645373 Common - flavin reductase domain protein FMN-binding Caul_1408 117 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 167644281 Common - transcriptional regulator, LacI family Caul_0309 127 COG1609 PurR, Transcriptional regulators Transcription 167646748 Common - glutamyl-tRNA synthetase Caul_2786 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 167645596 Common - ribosomal protein L30 Caul_1632 99 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 167646958 Common - Acid phosphatase Caul_2996 26 None None None 167647488 Common - integral membrane sensor hybrid histidine kinase Caul_3526 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167645271 Common - transcriptional regulator, MarR family Caul_1306 131 COG1846 MarR, Transcriptional regulators Transcription 167645654 Nonpathogen - hypothetical protein Caul_1690 7 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 167645406 Common - glucokinase Caul_1441 91 COG0837 Glk, Glucokinase Carbohydrate transport and metabolism 167648446 Common - protein of unknown function DUF179 Caul_4491 128 COG1678 COG1678, Putative transcriptional regulator Transcription 167645753 Common - arsenical resistance protein ArsH Caul_1789 57 COG0431 COG0431, Predicted flavoprotein General function prediction only 167645105 Common - putative PAS/PAC sensor protein Caul_1140 70 COG2202 AtoS, FOG: PAS/PAC domain Signal transduction mechanisms 167646931 Common - multi-sensor signal transduction histidine kinase Caul_2969 222 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 167644859 Nonpathogen - hypothetical protein Caul_0893 1 None None None 167648625 Common - protein of unknown function DUF132 Caul_4670 16 COG1569 COG1569, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 167645807 Common - TonB-dependent receptor Caul_1843 19 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647797 Common - conjugation TrbI family protein Caul_3836 57 COG2948 VirB10, Type IV secretory pathway, VirB10 components Intracellular trafficking and secretion 167645331 Common - flagellar basal-body rod protein FlgB, putative Caul_1366 26 COG1815 FlgB, Flagellar basal body protein Cell motility and secretion 167646785 Common - NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Caul_2823 87 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 167646090 Common - putative transposase of insertion sequence Caul_2127 35 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 167644899 Common - DEAD/DEAH box helicase domain protein Caul_0933 237 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 167646218 Common - TRAG family protein Caul_2256 78 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 167646925 Common - carbamate kinase Caul_2963 67 COG0549 ArcC, Carbamate kinase Amino acid transport and metabolism 167646053 Common - type II secretion system protein Caul_2090 145 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 167646948 Common - transcriptional regulator, GntR family Caul_2986 120 COG2188 PhnF, Transcriptional regulators Transcription 167647574 Common - Alpha-N-arabinofuranosidase Caul_3612 29 COG3534 AbfA, Alpha-L-arabinofuranosidase Carbohydrate transport and metabolism 167648949 Common - aldo/keto reductase Caul_4994 191 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 167645172 Common - phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I Caul_1207 207 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 167647842 Common - transcriptional repressor, CopY family Caul_3882 35 COG3682 COG3682, Predicted transcriptional regulator Transcription 167646515 Common - hypothetical protein Caul_2553 5 None None None 167646539 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Caul_2577 42 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 167648794 Common - succinate dehydrogenase, hydrophobic membrane anchor protein Caul_4839 31 COG2142 SdhD, Succinate dehydrogenase, hydrophobic anchor subunit Energy production and conversion 167648959 Common - malate dehydrogenase, NAD-dependent Caul_5004 197 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 167649022 Common - secretion protein HlyD family protein Caul_5067 122 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 167646797 Common - NADH-quinone oxidoreductase, B subunit Caul_2835 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 167648161 Common - hypothetical protein Caul_4202 49 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 167646883 Nonpathogen - hypothetical protein Caul_2921 1 None None None 167646477 Common - transcriptional regulator, AraC family Caul_2515 52 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 167647114 Common - hypothetical protein Caul_3152 17 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 167647173 Common - argininosuccinate lyase Caul_3211 234 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 167648038 Common - anti-FecI sigma factor, FecR Caul_4078 42 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 167648451 Nonpathogen - hypothetical protein Caul_4496 1 None None None 167648029 Common - hypothetical protein Caul_4069 79 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 167646105 Common - TonB-dependent receptor Caul_2142 20 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647481 Common - transcriptional regulator, XRE family Caul_3519 64 COG1476 COG1476, Predicted transcriptional regulators Transcription 167645916 Nonpathogen - hypothetical protein Caul_1952 8 None None None 167648001 Nonpathogen - hypothetical protein Caul_4041 1 COG3905 COG3905, Predicted transcriptional regulator Transcription 167647049 Common - Lytic transglycosylase catalytic Caul_3087 156 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 167645195 Common - periplasmic protein-like protein Caul_1230 36 COG3672 COG3672, Predicted periplasmic protein Function unknown 167644876 Common - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Caul_0910 152 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 167646324 Common - amidohydrolase Caul_2362 71 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 167647015 Common - PilT protein domain protein Caul_3053 13 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 167648342 Common - glycine cleavage system T protein Caul_4387 178 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 167646482 Common - 3-oxoacyl-(acyl-carrier-protein) synthase 2 Caul_2520 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167645766 Common - Extradiol ring-cleavage dioxygenase class III protein subunit B Caul_1802 86 COG3384 COG3384, Uncharacterized conserved protein Function unknown 167644308 Common - phage transcriptional regulator, AlpA Caul_0336 34 COG3311 AlpA, Predicted transcriptional regulator Transcription 167647736 Common - major facilitator superfamily MFS_1 Caul_3774 143 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167645081 Common - transcriptional regulator, ArsR family Caul_1116 33 COG0640 ArsR, Predicted transcriptional regulators Transcription 167648929 Common - Glucokinase Caul_4974 73 COG0837 Glk, Glucokinase Carbohydrate transport and metabolism 167647443 Nonpathogen - hypothetical protein Caul_3481 1 None None None 167646819 Common - heat shock protein Hsp20 Caul_2857 158 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 167646369 Common - TonB-dependent receptor Caul_2407 33 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167646117 Common - Amidase Caul_2154 214 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 167648393 Common - GCN5-related N-acetyltransferase Caul_4438 45 COG0456 RimI, Acetyltransferases General function prediction only 167645437 Common - PepSY-associated TM helix domain protein Caul_1472 44 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 167646433 Common - protein of unknown function DUF81 Caul_2471 34 COG0730 COG0730, Predicted permeases General function prediction only 167644577 Common - protein of unknown function DUF1244 Caul_0609 38 COG3492 COG3492, Uncharacterized protein conserved in bacteria Function unknown 167645531 Common - GPW/gp25 family protein Caul_1566 31 COG3628 COG3628, Phage baseplate assembly protein W General function prediction only 167646194 Common - ParB domain protein nuclease Caul_2232 102 COG1475 Spo0J, Predicted transcriptional regulators Transcription 167646145 Common - hypothetical protein Caul_2182 155 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 167644453 Common - TonB-dependent receptor Caul_0484 115 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167644039 Common - carbonic anhydrase Caul_0066 142 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 167648803 Nonpathogen - hypothetical protein Caul_4848 1 None None None 167645524 Nonpathogen - hypothetical protein Caul_1559 2 None None None 167644362 Common - integral membrane sensor signal transduction histidine kinase Caul_0390 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167644942 Nonpathogen - PE-PGRS family protein Caul_0977 1 None None None 167644614 Common - transcriptional regulator, TetR family Caul_0646 110 COG1309 AcrR, Transcriptional regulator Transcription 167645410 Common - acyl-CoA dehydrogenase domain protein Caul_1445 147 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167644632 Nonpathogen - membrane protein of unknown function Caul_0664 1 COG1950 COG1950, Predicted membrane protein Function unknown 167647633 Common - UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase Caul_3671 206 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 167646277 Nonpathogen - hypothetical protein Caul_2315 1 None None None 167646414 Common - beta-lactamase domain protein Caul_2452 120 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 167644384 Common - fumarylacetoacetase Caul_0412 44 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 167645685 Common - glycerol kinase Caul_1721 180 COG0554 GlpK, Glycerol kinase Energy production and conversion 167646305 Common - response regulator receiver protein Caul_2343 178 COG4566 TtrR, Response regulator Signal transduction mechanisms 167648458 Nonpathogen - hypothetical protein Caul_4503 1 None None None 167646591 Common - hypothetical protein Caul_2629 4 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 167645752 Common - putative transcriptional regulator, ArsR family Caul_1788 62 COG0640 ArsR, Predicted transcriptional regulators Transcription 167645951 Common - TonB-dependent receptor Caul_1988 104 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 167648893 Common - Glutathione S-transferase domain Caul_4938 99 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167646847 Nonpathogen - hypothetical protein Caul_2885 1 None None None 167644495 Common - aldo/keto reductase Caul_0526 196 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 167646400 Common - cytochrome c oxidase, cbb3-type, subunit II Caul_2438 82 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 167646548 Common - transcriptional regulator, BadM/Rrf2 family Caul_2586 169 COG1959 COG1959, Predicted transcriptional regulator Transcription 167646994 Common - integration host factor, alpha subunit Caul_3032 204 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 167645268 Common - glycoside hydrolase family 3 domain protein Caul_1303 114 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 167643994 Common - RNA modification enzyme, MiaB family Caul_0021 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 167646938 Nonpathogen - hypothetical protein Caul_2976 9 None None None 167647346 Common - hypothetical protein Caul_3384 9 COG1462 CsgG, Uncharacterized protein involved in formation of curli polymers Cell envelope biogenesis, outer membrane 167647904 Common - Glutamate--putrescine ligase Caul_3944 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 167648365 Common - ABC transporter related Caul_4410 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 167648383 Nonpathogen - hypothetical protein Caul_4428 1 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 167648074 Nonpathogen - hypothetical protein Caul_4115 1 None None None 167646357 Common - beta-lactamase domain protein Caul_2395 72 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 167644900 Common - PRC-barrel domain protein Caul_0934 32 None None None 167646235 Common - P-type conjugative transfer protein TrbL Caul_2273 24 COG3846 TrbL, Type IV secretory pathway, TrbL components Intracellular trafficking and secretion 167645227 Common - NMT1/THI5 like domain protein Caul_1262 56 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 167647838 Common - oxidoreductase molybdopterin binding Caul_3877 122 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 167647604 Common - transcriptional regulator, XRE family Caul_3642 53 COG3655 COG3655, Predicted transcriptional regulator Transcription 167647698 Common - hypothetical protein Caul_3736 18 None None None 167648922 Common - Dihydrodipicolinate reductase Caul_4967 214 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 167645799 Common - Mandelate racemase/muconate lactonizing protein Caul_1835 104 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 167645291 Common - Resolvase domain Caul_1326 138 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 167645962 Common - UBA/THIF-type NAD/FAD binding protein Caul_1999 81 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 167645469 Nonpathogen - hypothetical protein Caul_1504 1 COG5373 COG5373, Predicted membrane protein Function unknown 167646095 Common - Carboxylesterase type B Caul_2132 65 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 167645775 Common - Kelch repeat-containing protein Caul_1811 26 None None None 167646011 Common - acyl-CoA dehydrogenase domain protein Caul_2048 141 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167647529 Common - hypothetical protein Caul_3567 12 COG3218 COG3218, ABC-type uncharacterized transport system, auxiliary component General function prediction only 167648403 Common - hypothetical protein Caul_4448 52 COG3665 COG3665, Uncharacterized conserved protein Function unknown 167645014 Common - ATP--cobalamin adenosyltransferase Caul_1049 130 COG2096 COG2096, Uncharacterized conserved protein Function unknown 167645189 Common - peptidase M23B Caul_1224 177 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 167648976 Common - Carboxymethylenebutenolidase Caul_5021 99 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 167648048 Common - alpha amylase catalytic region Caul_4089 166 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 167648648 Common - SapC family protein Caul_4693 26 None None None 167644751 Common - DNA recombination protein RuvA domain I Caul_0785 204 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 167645452 Nonpathogen - O-methyltransferase family 3 Caul_1487 8 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 167645004 Common - Carboxylesterase type B Caul_1039 58 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 167645992 Common - putative conjugal transfer TrbD transmembrane protein Caul_2029 22 COG5268 TrbD, Type IV secretory pathway, TrbD component Cell motility and secretion / Intracellular trafficking and secretion 167648704 Common - Abortive infection protein Caul_4749 27 None None None 167646850 Common - flagellar FlaF family protein Caul_2888 23 COG5442 FlaF, Flagellar biosynthesis regulator FlaF Cell motility and secretion 167644432 Nonpathogen - hypothetical protein Caul_0463 1 None None None 167646836 Common - adenosylmethionine-8-amino-7-oxononanoate aminotransferase Caul_2874 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 167647836 Common - Membrane dipeptidase Caul_3875 96 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 167648231 Nonpathogen - hypothetical protein Caul_4275 1 None None None 167645353 Common - GCN5-related N-acetyltransferase Caul_1388 36 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 167648232 Nonpathogen - plasmid stabilization system Caul_4276 2 COG3668 ParE, Plasmid stabilization system protein General function prediction only 167648968 Common - shikimate 5-dehydrogenase Caul_5013 203 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 167648376 Common - dihydropteroate synthase Caul_4421 217 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 167644049 Common - hypothetical protein Caul_0076 17 COG3652 COG3652, Predicted outer membrane protein Function unknown 167647000 Common - response regulator receiver protein Caul_3038 219 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 167647402 Common - Uracil-DNA glycosylase superfamily Caul_3440 41 COG3663 Mug, G:T/U mismatch-specific DNA glycosylase DNA replication, recombination, and repair 167648908 Common - NADH dehydrogenase Caul_4953 130 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167646752 Common - integral membrane sensor hybrid histidine kinase Caul_2790 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167646910 Common - acyl-CoA dehydrogenase domain protein Caul_2948 157 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167646204 Common - peptidase S9 prolyl oligopeptidase active site domain protein Caul_2242 84 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 167646131 Common - Tetratricopeptide TPR_2 repeat protein Caul_2168 134 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 167644530 Common - cytochrome c, class I Caul_0562 12 None None None 167644651 Common - transcriptional regulator, MarR family Caul_0683 91 COG1846 MarR, Transcriptional regulators Transcription 167645800 Common - Alpha-glucuronidase Caul_1836 15 COG3661 AguA, Alpha-glucuronidase Carbohydrate transport and metabolism 167644402 Common - major facilitator superfamily MFS_1 Caul_0430 61 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 167647363 Common - transcriptional regulator, LysR family Caul_3401 48 COG0583 LysR, Transcriptional regulator Transcription 167646688 Common - TonB-dependent receptor plug Caul_2726 46 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647203 Common - short-chain dehydrogenase/reductase SDR Caul_3241 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167647548 Common - protein tyrosine phosphatase Caul_3586 84 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 167648045 Common - glucan 1,4-alpha-glucosidase Caul_4086 25 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 167648401 Common - putative transcriptional regulator, CopG family Caul_4446 59 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 167647800 Common - amine oxidase Caul_3839 57 COG1231 COG1231, Monoamine oxidase Amino acid transport and metabolism 167644710 Common - CheW protein Caul_0744 134 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 167648505 Common - phosphate ABC transporter, inner membrane subunit PstC Caul_4550 227 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 167646307 Common - PAS/PAC sensor signal transduction histidine kinase Caul_2345 222 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 167645964 Common - thymidylate synthase Caul_2001 124 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 167647223 Common - hypothetical protein Caul_3261 3 None None None 167644040 Common - alpha-2-macroglobulin domain protein Caul_0067 80 COG2373 COG2373, Large extracellular alpha-helical protein General function prediction only 167647504 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Caul_3542 73 COG3200 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 167644128 Common - Ricin B lectin Caul_0156 12 None None None 167645950 Common - peptidase S9 prolyl oligopeptidase active site domain protein Caul_1987 37 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 167644559 Common - TonB-dependent receptor Caul_0591 82 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 167645126 Common - hypothetical protein Caul_1161 4 None None None 167644616 Nonpathogen - hypothetical protein Caul_0648 1 None None None 167646764 Common - ribosome recycling factor Caul_2802 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 167644692 Common - integrase family protein Caul_0724 229 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 167648314 Common - glycosyl transferase family 9 Caul_4359 109 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 167645866 Common - hypothetical protein Caul_1902 90 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167644591 Nonpathogen - hypothetical protein Caul_0623 1 None None None 167644005 Common - protein of unknown function DUF448 Caul_0032 38 COG2740 COG2740, Predicted nucleic-acid-binding protein implicated in transcription termination Transcription 167648095 Common - transcriptional regulator, XRE family Caul_4136 71 COG1476 COG1476, Predicted transcriptional regulators Transcription 167648607 Common - electron transport protein SCO1/SenC Caul_4652 100 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 167648178 Common - transcriptional regulator, GntR family Caul_4219 112 COG2188 PhnF, Transcriptional regulators Transcription 167644673 Common - dienelactone hydrolase Caul_0705 89 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 167646612 Common - hypothetical protein Caul_2650 13 None None None 167648753 Common - short-chain dehydrogenase/reductase SDR Caul_4798 37 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 167645719 Common - transcriptional regulator, LacI family Caul_1755 128 COG1609 PurR, Transcriptional regulators Transcription 167645214 Nonpathogen - hypothetical protein Caul_1249 1 None None None 167648116 Common - integrase family protein Caul_4157 66 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 167644515 Common - hypothetical protein Caul_0546 23 None None None 167644721 Common - DoxX family protein Caul_0755 29 COG2259 COG2259, Predicted membrane protein Function unknown 167647315 Common - acetolactate synthase, small subunit Caul_3353 191 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 167647941 Common - alpha/beta hydrolase fold Caul_3981 108 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167646082 Common - glycosyl transferase group 1 Caul_2119 99 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 167647696 Common - peptidase M16 domain protein Caul_3734 188 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 167647457 Nonpathogen - hypothetical protein Caul_3495 1 None None None 167644837 Common - lytic murein transglycosylase Caul_0871 102 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 167645248 Common - glycoside hydrolase family 5 Caul_1283 18 COG2730 BglC, Endoglucanase Carbohydrate transport and metabolism 167648274 Common - transcriptional regulator, AraC family Caul_4319 105 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 167645441 Common - signal transduction histidine kinase Caul_1476 95 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 167645541 Common - Mammalian cell entry related domain protein Caul_1576 44 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 167645838 Common - acyl-CoA dehydrogenase domain protein Caul_1874 164 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167647197 Nonpathogen - hypothetical protein Caul_3235 8 None None None 167644769 Common - translation elongation factor G Caul_0803 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 167644000 Common - Methionine adenosyltransferase Caul_0027 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 167644920 Common - conserved hypothetical protein-like protein Caul_0955 71 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 167646888 Common - cystathionine beta-lyase Caul_2926 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 167646735 Common - hypothetical protein Caul_2773 17 COG5483 COG5483, Uncharacterized conserved protein Function unknown 167647785 Common - hypothetical protein Caul_3824 27 COG3843 VirD2, Type IV secretory pathway, VirD2 components (relaxase) Intracellular trafficking and secretion 167646290 Nonpathogen - hypothetical protein Caul_2328 1 None None None 167644720 Common - hypothetical protein Caul_0754 8 None None None 167648385 Common - protein TolQ Caul_4430 145 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 167648850 Common - thioesterase superfamily protein Caul_4895 33 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 167645871 Common - AMP-dependent synthetase and ligase Caul_1907 219 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167644152 Common - GCN5-related N-acetyltransferase Caul_0180 15 COG3153 COG3153, Predicted acetyltransferase General function prediction only 167645229 Common - sodium/hydrogen exchanger Caul_1264 23 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 167646316 Common - hypothetical protein Caul_2354 6 COG5653 COG5653, Protein involved in cellulose biosynthesis (CelD) Cell envelope biogenesis, outer membrane 167648158 Common - hypothetical protein Caul_4199 15 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 167645611 Nonpathogen - activator of HSP90 ATPase 1 family protein Caul_1647 5 COG3832 COG3832, Uncharacterized conserved protein Function unknown 167646407 Common - OmpW family protein Caul_2445 70 COG3047 OmpW, Outer membrane protein W Cell envelope biogenesis, outer membrane 167647781 Common - hypothetical protein Caul_3820 23 None None None 167648835 Common - peroxiredoxin Caul_4880 222 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 167648146 Common - thioesterase superfamily protein Caul_4187 130 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 167646635 Common - protein of unknown function DUF323 Caul_2673 105 COG1262 COG1262, Uncharacterized conserved protein Function unknown 167647164 Common - GreA/GreB family elongation factor Caul_3202 107 COG0782 GreA, Transcription elongation factor Transcription 167647060 Common - acyltransferase 3 Caul_3098 32 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 167648901 Common - rfaE bifunctional protein Caul_4946 110 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 167647998 Nonpathogen - hypothetical protein Caul_4038 1 None None None 167645812 Common - putative transposase of insertion sequence ISRm2011-2, orfA protein Caul_1848 20 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 167644986 Common - Endo-1,4-beta-xylanase Caul_1021 33 COG3693 XynA, Beta-1,4-xylanase Carbohydrate transport and metabolism 167646823 Common - 3-hydroxybutyryl-CoA dehydrogenase Caul_2861 161 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 167646468 Common - alanine racemase Caul_2506 199 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 167647541 Nonpathogen - TonB family protein Caul_3579 1 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 167645516 Common - L-fucose transporter Caul_1551 46 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 167646517 Common - hypothetical protein Caul_2555 8 None None None 167646104 Common - transcriptional regulator, LacI family Caul_2141 126 COG1609 PurR, Transcriptional regulators Transcription 167646575 Common - MazG family protein Caul_2613 158 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 167645545 Common - Glutathione S-transferase domain Caul_1580 103 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167647774 Common - hypothetical protein Caul_3813 12 None None None 167648218 Common - protein of unknown function DUF6 transmembrane Caul_4262 144 None None None 167647414 Common - Phosphoglycerate mutase Caul_3452 122 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 167646362 Common - TonB-dependent receptor Caul_2400 22 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 167646284 Common - transcriptional regulator, MerR family Caul_2322 130 COG0789 SoxR, Predicted transcriptional regulators Transcription 167645809 Common - transcription factor jumonji jmjC domain protein Caul_1845 20 COG2850 COG2850, Uncharacterized conserved protein Function unknown 167647468 Nonpathogen - hypothetical protein Caul_3506 3 COG1110 COG1110, Reverse gyrase DNA replication, recombination, and repair 167645675 Common - Squalene/phytoene synthase Caul_1711 101 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 167645623 Nonpathogen - hypothetical protein Caul_1659 1 None None None 167646463 Common - Bile acid:sodium symporter Caul_2501 55 COG0385 COG0385, Predicted Na+-dependent transporter General function prediction only 167644212 Common - primosomal protein N' Caul_0240 210 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 167647248 Common - two component transcriptional regulator, winged helix family Caul_3286 213 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167644927 Common - major facilitator superfamily MFS_1 Caul_0962 142 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 167645266 Nonpathogen - hypothetical protein Caul_1301 1 None None None 167646877 Common - hypothetical protein Caul_2915 12 None None None 167648597 Common - methyltransferase Caul_4642 211 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 167648023 Nonpathogen - hypothetical protein Caul_4063 2 None None None 167647896 Common - transcriptional regulator, TetR family Caul_3936 54 COG3226 COG3226, Uncharacterized protein conserved in bacteria Function unknown 167645288 Nonpathogen - hypothetical protein Caul_1323 3 None None None 167647683 Common - hydroxyisourate hydrolase Caul_3721 63 COG2351 COG2351, Transthyretin-like protein General function prediction only 167648556 Common - beta-lactamase Caul_4601 144 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 167648282 Common - transcriptional regulator, AsnC family Caul_4327 151 COG1522 Lrp, Transcriptional regulators Transcription 167647829 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Caul_3868 119 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 167647024 Common - Arginyltransferase Caul_3062 85 COG2935 COG2935, Putative arginyl-tRNA:protein arginylyltransferase Posttranslational modification, protein turnover, chaperones 167647835 Nonpathogen - hypothetical protein Caul_3874 10 None None None 167646078 Common - hypothetical protein Caul_2115 49 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 167645910 Common - acetoacetyl-CoA reductase Caul_1946 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167646123 Nonpathogen - hypothetical protein Caul_2160 1 None None None 167644074 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Caul_0101 231 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 167645984 Nonpathogen - hypothetical protein Caul_2021 2 None None None 167647622 Common - D-alanine--D-alanine ligase Caul_3660 210 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 167645739 Common - acyltransferase 3 Caul_1775 11 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 167645375 Common - peptidase M15D vanX D-ala-D-ala dipeptidase Caul_1410 55 COG2173 DdpX, D-alanyl-D-alanine dipeptidase Cell envelope biogenesis, outer membrane 167646861 Common - hypothetical protein Caul_2899 63 COG4111 COG4111, Uncharacterized conserved protein General function prediction only 167646892 Common - glucose-methanol-choline oxidoreductase Caul_2930 81 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 167645509 Common - short-chain dehydrogenase/reductase SDR Caul_1544 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167644442 Common - DNA-directed DNA polymerase Caul_0473 185 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 167646189 Nonpathogen - transcriptional regulator, XRE family Caul_2226 2 COG2944 COG2944, Predicted transcriptional regulator Transcription 167644117 Common - Alpha,alpha-trehalase Caul_0144 27 COG1626 TreA, Neutral trehalase Carbohydrate transport and metabolism 167648290 Nonpathogen - hypothetical protein Caul_4335 1 None None None 167645118 Nonpathogen - hypothetical protein Caul_1153 2 None None None 167648818 Common - hypothetical protein Caul_4863 39 COG4680 COG4680, Uncharacterized protein conserved in bacteria Function unknown 167646802 Nonpathogen - hypothetical protein Caul_2840 1 COG4877 COG4877, Uncharacterized protein conserved in bacteria Function unknown 167644225 Nonpathogen - hypothetical protein Caul_0253 1 None None None 167644840 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Caul_0874 34 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 167648337 Nonpathogen - hypothetical protein Caul_4382 1 None None None 167644523 Common - histone deacetylase superfamily Caul_0555 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 167645103 Common - transcriptional regulator, GntR family Caul_1138 125 COG1802 GntR, Transcriptional regulators Transcription 167646807 Common - ATP-dependent protease La Caul_2845 232 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 167644220 Common - dTDP-6-deoxy-L-hexose 3-O-methyltransferase Caul_0248 24 None None None 167644271 Common - alpha/beta hydrolase fold Caul_0299 144 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167648690 Common - H+transporting two-sector ATPase delta/epsilon subunit Caul_4735 174 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 167648660 Common - sodium:dicarboxylate symporter Caul_4705 161 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 167648164 Common - penicillin-binding protein, 1A family Caul_4205 204 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 167645369 Common - phage shock protein A, PspA Caul_1404 29 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 167647767 Common - DNA helicase II Caul_3806 22 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 167648498 Common - aminoglycoside phosphotransferase Caul_4543 58 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 167644826 Common - Transglycosylase-associated protein Caul_0860 38 COG2261 COG2261, Predicted membrane protein Function unknown 167644996 Common - transposase IS3/IS911 family protein Caul_1031 44 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 167648863 Nonpathogen - hypothetical protein Caul_4908 1 None None None 167646383 Common - hypothetical protein Caul_2421 13 COG5591 COG5591, Uncharacterized conserved protein Function unknown 167648005 Nonpathogen - hypothetical protein Caul_4045 3 None None None 167645760 Common - Taurine dioxygenase Caul_1796 47 COG2175 TauD, Probable taurine catabolism dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 167648574 Common - RarD protein, DMT superfamily transporter Caul_4619 95 COG2962 RarD, Predicted permeases General function prediction only 167645333 Common - flagellar hook-basal body complex subunit FliE Caul_1368 24 COG1677 FliE, Flagellar hook-basal body protein Cell motility and secretion / Intracellular trafficking and secretion 167647517 Common - transcriptional regulator, LacI family Caul_3555 127 COG1609 PurR, Transcriptional regulators Transcription 167645562 Common - proline iminopeptidase Caul_1598 117 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167645477 Common - protein of unknown function DUF1568 Caul_1512 55 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 167643986 Common - ferric uptake regulator, Fur family Caul_0013 195 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 167647250 Common - Beta-glucosidase Caul_3288 109 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 167648658 Common - potassium efflux system protein Caul_4703 196 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 167644856 Nonpathogen - aa3 type cytochrome c oxidase subunit IV Caul_0890 1 None None None 167648699 Common - FAD dependent oxidoreductase Caul_4744 13 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 167648214 Nonpathogen - hypothetical protein Caul_4258 1 None None None 167644589 Common - two component transcriptional regulator, LuxR family Caul_0621 207 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 167644830 Nonpathogen - hypothetical protein Caul_0864 1 None None None 167648811 Common - transcriptional regulator, TetR family Caul_4856 63 COG1309 AcrR, Transcriptional regulator Transcription 167646632 Common - beta-lactamase domain protein Caul_2670 102 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 167647888 Common - protein of unknown function DUF6 transmembrane Caul_3928 56 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 167644580 Common - CheA signal transduction histidine kinase Caul_0612 149 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 167647856 Common - two component transcriptional regulator, winged helix family Caul_3896 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167648683 Common - arylesterase-related protein Caul_4728 35 COG2267 PldB, Lysophospholipase Lipid metabolism 167644429 Common - Aldehyde Dehydrogenase_ Caul_0457 222 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167645027 Common - SH3 type 3 domain protein Caul_1062 4 COG3134 COG3134, Predicted outer membrane lipoprotein Function unknown 167648654 Common - hypothetical protein Caul_4699 35 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 167646268 Common - transcriptional regulator, TetR family Caul_2306 25 COG1309 AcrR, Transcriptional regulator Transcription 167647379 Nonpathogen - hypothetical protein Caul_3417 1 None None None 167644266 Common - phosphoenolpyruvate-protein phosphotransferase Caul_0294 233 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 167645891 Common - fumarylacetoacetate (FAA) hydrolase Caul_1927 178 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 167648933 Common - acetyl-CoA carboxylase, carboxyl transferase, beta subunit Caul_4978 216 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 167644634 Common - Aminoacyl-tRNA hydrolase Caul_0666 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 167645847 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Caul_1883 21 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 167644699 Nonpathogen - hypothetical protein Caul_0733 1 None None None 167645920 Common - Poly-beta-hydroxybutyrate polymerase domain protein Caul_1956 76 COG3243 PhaC, Poly(3-hydroxyalkanoate) synthetase Lipid metabolism 167644935 Common - TonB-dependent receptor Caul_0970 32 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167645840 Common - Carbamoyl-phosphate synthase L chain ATP-binding Caul_1876 234 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 167645317 Common - glycosyl transferase family 2 Caul_1352 50 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 167645535 Nonpathogen - PASTA domain containing protein Caul_1570 3 COG2815 COG2815, Uncharacterized protein conserved in bacteria Function unknown 167646089 Common - TonB-dependent receptor Caul_2126 34 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647646 Common - Enoyl-CoA hydratase/isomerase Caul_3684 182 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 167645204 Nonpathogen - hypothetical protein Caul_1239 2 None None None 167646346 Common - glycerophosphoryl diester phosphodiesterase Caul_2384 127 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 167646868 Nonpathogen - hypothetical protein Caul_2906 1 COG4691 StbC, Plasmid stability protein General function prediction only 167646150 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Caul_2187 70 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 167647770 Common - hypothetical protein Caul_3809 11 None None None 167645778 Nonpathogen - hypothetical protein Caul_1814 14 COG3501 VgrG, Uncharacterized protein conserved in bacteria Function unknown 167647199 Common - short-chain dehydrogenase/reductase SDR Caul_3237 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 167648539 Common - NLP/P60 protein Caul_4584 98 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 167648919 Common - hypothetical protein Caul_4964 12 COG3784 COG3784, Uncharacterized protein conserved in bacteria Function unknown 167645235 Common - thiolase family protein Caul_1270 101 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167644390 Common - fumarylacetoacetate (FAA) hydrolase Caul_0418 172 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 167645591 Common - ribosomal protein S14 Caul_1627 205 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 167645696 Common - orotate phosphoribosyltransferase Caul_1732 115 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 167644311 Common - transposase IS3/IS911 family protein Caul_0339 44 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 167648646 Common - cytochrome c biogenesis protein transmembrane region Caul_4691 76 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 167645020 Common - beta-lactamase Caul_1055 125 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 167646457 Common - 3-methyl-2-oxobutanoate hydroxymethyltransferase Caul_2495 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 167644683 Common - BolA family protein Caul_0715 52 COG0271 BolA, Stress-induced morphogen (activity unknown) Signal transduction mechanisms 167646159 Common - transglutaminase domain protein Caul_2196 110 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 167646685 Common - thiamine pyrophosphate protein central region Caul_2723 217 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 167647327 Common - protein of unknown function DUF74 Caul_3365 96 COG0393 COG0393, Uncharacterized conserved protein Function unknown 167648525 Common - peptide deformylase Caul_4570 213 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 167648990 Common - hypothetical protein Caul_5035 42 COG3786 COG3786, Uncharacterized protein conserved in bacteria Function unknown 167647652 Common - chemotactic signal-response protein CheL Caul_3690 20 COG3951 COG3951, Rod binding protein Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 167644232 Common - phosphonate ABC transporter, periplasmic phosphonate-binding protein Caul_0260 77 COG3221 PhnD, ABC-type phosphate/phosphonate transport system, periplasmic component Inorganic ion transport and metabolism 167648132 Common - Integrase catalytic region Caul_4173 79 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 167647819 Common - ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent Caul_3858 221 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 167648128 Nonpathogen - hypothetical protein Caul_4169 1 None None None 167644463 Common - Saccharopine dehydrogenase Caul_0494 20 COG3268 COG3268, Uncharacterized conserved protein Function unknown 167644896 Nonpathogen - hypothetical protein Caul_0930 4 None None None 167647075 Common - protein-L-isoaspartate O-methyltransferase Caul_3113 154 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 167646297 Common - hypothetical protein Caul_2335 4 None None None 167645250 Common - SSS sodium solute transporter superfamily Caul_1285 159 COG4146 COG4146, Predicted symporter General function prediction only 167648910 Common - protein of unknown function DUF1239 Caul_4955 14 COG5375 COG5375, Uncharacterized protein conserved in bacteria Function unknown 167644370 Common - Cobyrinic acid ac-diamide synthase Caul_0398 181 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 167646279 Common - heavy metal translocating P-type ATPase Caul_2317 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 167645245 Common - acriflavin resistance protein Caul_1280 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 167646745 Common - glutathione-dependent formaldehyde-activating GFA Caul_2783 51 COG3791 COG3791, Uncharacterized conserved protein Function unknown 167647321 Common - protein of unknown function DUF1321 Caul_3359 40 COG3814 COG3814, Uncharacterized protein conserved in bacteria Function unknown 167647152 Common - transcriptional regulator, MarR family Caul_3190 46 COG1846 MarR, Transcriptional regulators Transcription 167647592 Common - methylmalonyl-CoA mutase, large subunit Caul_3630 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 167644239 Common - metallophosphoesterase Caul_0267 70 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 167646134 Common - nitrogen regulatory protein P-II Caul_2171 187 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 167646729 Common - GCN5-related N-acetyltransferase Caul_2767 31 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 167647956 Common - transposase IS116/IS110/IS902 family protein Caul_3996 52 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 167648308 Common - thiamine pyrophosphate protein domain protein TPP-binding Caul_4353 194 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 167648767 Common - glycosyl transferase family 2 Caul_4812 44 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 167648191 Common - transport-associated Caul_4234 43 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 167647026 Common - 2-nitropropane dioxygenase NPD Caul_3064 144 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 167646174 Common - ribosomal RNA methyltransferase RrmJ/FtsJ Caul_2211 138 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 167645999 Common - hypothetical protein Caul_2036 6 COG5639 COG5639, Uncharacterized conserved small protein Function unknown 167646536 Common - penicillin-binding protein, 1A family Caul_2574 201 COG5009 MrcA, Membrane carboxypeptidase/penicillin-binding protein Cell envelope biogenesis, outer membrane 167648420 Common - Enoyl-CoA hydratase/isomerase Caul_4465 174 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 167646384 Common - cytochrome B561 Caul_2422 41 COG3658 COG3658, Cytochrome b Energy production and conversion 167647040 Nonpathogen - hypothetical protein Caul_3078 2 None None None 167644661 Common - protein of unknown function DUF1285 Caul_0693 45 COG3816 COG3816, Uncharacterized protein conserved in bacteria Function unknown 167645680 Common - FAD-linked oxidoreductase Caul_1716 31 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 167644845 Common - two component, sigma54 specific, transcriptional regulator, Fis family Caul_0879 215 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 167646667 Common - SirA family protein Caul_2705 35 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 167647968 Common - TonB-dependent receptor plug Caul_4008 113 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 167649004 Common - hypothetical protein Caul_5049 21 COG5488 COG5488, Integral membrane protein Function unknown 167647741 Common - transcriptional regulator, AraC family Caul_3779 63 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 167648285 Common - response regulator receiver protein Caul_4330 68 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 167648997 Common - imidazoleglycerol phosphate synthase, cyclase subunit Caul_5042 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 167646024 Common - DSBA oxidoreductase Caul_2061 83 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 167645586 Common - ribosomal protein L29 Caul_1622 162 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 167646569 Common - multi-sensor signal transduction histidine kinase Caul_2607 214 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 167646260 Common - protein of unknown function DUF190 Caul_2298 48 COG1993 COG1993, Uncharacterized conserved protein Function unknown 167645851 Common - short-chain dehydrogenase/reductase SDR Caul_1887 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167645091 Common - transcriptional regulator, AsnC family Caul_1126 4 COG1522 Lrp, Transcriptional regulators Transcription 167647013 Common - hypothetical protein Caul_3051 31 COG4798 COG4798, Predicted methyltransferase General function prediction only 167644831 Common - OmpA/MotB domain protein Caul_0865 81 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 167645482 Common - aspartate carbamoyltransferase Caul_1517 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 167647411 Common - phosphoribosylformylglycinamidine synthase I Caul_3449 230 COG0047 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain Nucleotide transport and metabolism 167645065 Common - Hemolysin-type calcium-binding region Caul_1100 136 None None None 167644348 Common - transposase and inactivated derivatives-like protein Caul_0376 46 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646352 Common - transcriptional regulator, AraC family Caul_2390 123 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 167644091 Common - porphobilinogen deaminase Caul_0118 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 167647005 Common - thiamine-monophosphate kinase Caul_3043 176 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 167644368 Common - hypothetical protein Caul_0396 2 None None None 167647731 Common - multi-sensor hybrid histidine kinase Caul_3769 224 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167644144 Common - non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family Caul_0172 236 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 167645558 Nonpathogen - hypothetical protein Caul_1593 1 None None None 167646447 Common - protein of unknown function DUF899 thioredoxin family protein Caul_2485 28 COG4312 COG4312, Uncharacterized protein conserved in bacteria Function unknown 167645792 Common - hypothetical protein Caul_1828 5 None None None 167648669 Common - hypothetical protein Caul_4714 18 None None None 167646114 Nonpathogen - hypothetical protein Caul_2151 1 None None None 167648848 Nonpathogen - hypothetical protein Caul_4893 1 None None None 167646494 Common - DNA polymerase III chi subunit HolC Caul_2532 52 COG2927 HolC, DNA polymerase III, chi subunit DNA replication, recombination, and repair 167647372 Common - transcriptional regulator, ArsR family Caul_3410 109 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 167645358 Common - protein of unknown function DUF347 Caul_1393 27 COG4705 COG4705, Uncharacterized membrane-anchored protein conserved in bacteria Function unknown 167648462 Common - transcriptional regulator, PadR-like family Caul_4507 59 COG1695 COG1695, Predicted transcriptional regulators Transcription 167648600 Nonpathogen - hypothetical protein Caul_4645 1 None None None 167646556 Common - FeS assembly SUF system protein Caul_2594 144 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 167644864 Common - peptidase M23B Caul_0898 190 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 167648434 Nonpathogen - hypothetical protein Caul_4479 1 None None None 167644418 Common - acyl-CoA dehydrogenase domain protein Caul_0446 157 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167645726 Nonpathogen - hypothetical protein Caul_1762 1 None None None 167648207 Common - Activator of Hsp90 ATPase 1 family protein Caul_4251 52 COG3832 COG3832, Uncharacterized conserved protein Function unknown 167646426 Nonpathogen - hypothetical protein Caul_2464 1 None None None 167647274 Nonpathogen - hypothetical protein Caul_3312 1 None None None 167645639 Nonpathogen - hypothetical protein Caul_1675 1 None None None 167646496 Nonpathogen - hypothetical protein Caul_2534 1 COG5411 COG5411, Phosphatidylinositol 5-phosphate phosphatase Signal transduction mechanisms 167645491 Common - Glutathione S-transferase domain Caul_1526 98 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167648994 Common - MltA domain protein Caul_5039 93 COG2821 MltA, Membrane-bound lytic murein transglycosylase Cell envelope biogenesis, outer membrane 167646064 Common - TonB family protein Caul_2101 8 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 167646308 Common - copper resistance D domain protein Caul_2346 16 COG1276 PcoD, Putative copper export protein Inorganic ion transport and metabolism 167644644 Common - Protein of unknown function DUF1790 Caul_0676 34 COG5465 COG5465, Uncharacterized conserved protein Function unknown 167644249 Common - CheX protein Caul_0277 7 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 167647473 Nonpathogen - hypothetical protein Caul_3511 1 None None None 167647883 Common - ABC transporter related Caul_3923 248 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 167647859 Common - transcriptional regulator/antitoxin, MazE Caul_3899 29 COG2336 MazE, Growth regulator Signal transduction mechanisms 167644426 Nonpathogen - DoxX family protein Caul_0454 2 None None None 167644108 Common - NAD-dependent epimerase/dehydratase Caul_0135 219 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167647893 Common - Glutathione S-transferase domain Caul_3933 82 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167648798 Common - AFG1-family ATPase Caul_4843 100 COG1485 COG1485, Predicted ATPase General function prediction only 167644626 Common - Adenylosuccinate synthase Caul_0658 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 167645698 Common - holo-acyl-carrier-protein synthase Caul_1734 152 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 167644758 Common - diguanylate phosphodiesterase Caul_0792 158 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 167644407 Common - transcriptional regulator, TetR family Caul_0435 48 COG1309 AcrR, Transcriptional regulator Transcription 167648635 Common - tRNA synthetase class II (G H P and S) Caul_4680 26 COG3705 HisZ, ATP phosphoribosyltransferase involved in histidine biosynthesis Amino acid transport and metabolism 167644072 Common - 3'(2'),5'-bisphosphate nucleotidase Caul_0099 183 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 167648009 Common - hypothetical protein Caul_4049 24 COG3826 COG3826, Uncharacterized protein conserved in bacteria Function unknown 167646817 Common - nitroreductase Caul_2855 111 COG0778 NfnB, Nitroreductase Energy production and conversion 167644067 Common - hypothetical protein Caul_0094 3 None None None 167647149 Common - secretion protein HlyD family protein Caul_3187 116 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 167646344 Common - regulatory protein PupR, putative Caul_2382 30 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 167647140 Nonpathogen - hypothetical protein Caul_3178 1 None None None 167647533 Common - hypothetical protein Caul_3571 15 COG5330 COG5330, Uncharacterized protein conserved in bacteria Function unknown 167645518 Common - anti-ECFsigma factor, ChrR Caul_1553 29 COG3806 ChrR, Transcriptional activator Transcription 167645938 Common - aromatic-ring-hydroxylating dioxygenase beta subunit Caul_1975 18 COG5517 COG5517, Small subunit of phenylpropionate dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 167647435 Nonpathogen - hypothetical protein Caul_3473 1 None None None 167646984 Common - SpoVT/AbrB domain protein Caul_3022 11 None None None 167648448 Common - diguanylate cyclase/phosphodiesterase Caul_4493 163 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 167648195 Common - two component transcriptional regulator, winged helix family Caul_4238 220 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167646168 Common - GCN5-related N-acetyltransferase Caul_2205 33 COG0456 RimI, Acetyltransferases General function prediction only 167645687 Common - protein of unknown function DUF88 Caul_1723 63 COG1432 COG1432, Uncharacterized conserved protein Function unknown 167648142 Common - Xanthine/uracil/vitamin C permease Caul_4183 134 COG2252 COG2252, Permeases General function prediction only 167647280 Common - Phosphoglycerate mutase Caul_3318 7 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 167646412 Common - NAD(P)H dehydrogenase (quinone) Caul_2450 70 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 167646972 Common - cold-shock DNA-binding domain protein Caul_3010 148 COG1278 CspC, Cold shock proteins Transcription 167648547 Common - hypothetical protein Caul_4592 32 COG3911 COG3911, Predicted ATPase General function prediction only 167644579 Common - response regulator receiver protein Caul_0611 221 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 167645382 Common - aldehyde oxidase and xanthine dehydrogenase molybdopterin binding Caul_1417 112 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 167648760 Common - glycosyl transferase family 2 Caul_4805 57 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 167644961 Common - multi-sensor hybrid histidine kinase Caul_0996 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167646885 Nonpathogen - N-acetylmuramoyl-L-alanine amidase family 2 Caul_2923 4 None None None 167645664 Common - signal transduction histidine kinase Caul_1700 66 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 167646554 Common - SufBD protein Caul_2592 168 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 167644189 Common - ribosomal protein L19 Caul_0217 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 167647239 Common - glycoside hydrolase family 31 Caul_3277 83 COG1501 COG1501, Alpha-glucosidases, family 31 of glycosyl hydrolases Carbohydrate transport and metabolism 167647756 Common - integrase family protein Caul_3795 37 None None None 167647848 Common - two component transcriptional regulator, winged helix family Caul_3888 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167645744 Common - glycosyl transferase group 1 Caul_1780 133 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 167644033 Common - molybdenum cofactor biosynthesis protein C Caul_0060 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 167646355 Common - alpha/beta hydrolase fold Caul_2393 59 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167648809 Common - thioredoxin Caul_4854 232 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 167648931 Common - tryptophan synthase, beta subunit Caul_4976 225 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 167648268 Nonpathogen - hypothetical protein Caul_4313 1 None None None 167648677 Common - protein of unknown function DUF163 Caul_4722 163 COG1576 COG1576, Uncharacterized conserved protein Function unknown 167648181 Common - protein of unknown function DUF156 Caul_4224 37 COG1937 COG1937, Uncharacterized protein conserved in bacteria Function unknown 167646979 Nonpathogen - hypothetical protein Caul_3017 1 None None None 167648263 Common - quinolinate synthetase complex, A subunit Caul_4308 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 167645937 Common - Rieske (2Fe-2S) domain protein Caul_1974 80 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 167648441 Common - Sua5/YciO/YrdC/YwlC family protein Caul_4486 222 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 167645948 Common - hypothetical protein Caul_1985 3 None None None 167648988 Common - thiamine monophosphate synthase Caul_5033 41 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 167644979 Nonpathogen - flbE protein Caul_1014 4 None None None 167645973 Common - hypothetical protein Caul_2010 19 None None None 167644549 Common - pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase Caul_0581 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 167644735 Common - protein of unknown function DUF710 Caul_0769 23 COG3027 COG3027, Uncharacterized protein conserved in bacteria Function unknown 167645278 Common - hypothetical protein Caul_1313 58 COG2187 COG2187, Uncharacterized protein conserved in bacteria Function unknown 167644798 Common - Glucokinase Caul_0832 90 COG0837 Glk, Glucokinase Carbohydrate transport and metabolism 167647133 Common - hypothetical protein Caul_3171 35 COG5587 COG5587, Uncharacterized conserved protein Function unknown 167644333 Common - fatty acid desaturase Caul_0361 24 COG3239 DesA, Fatty acid desaturase Lipid metabolism 167648528 Common - recombination protein RecR Caul_4573 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 167646776 Common - methylmalonyl-CoA epimerase Caul_2814 92 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 167647301 Common - ABC transporter related Caul_3339 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 167648873 Common - NAD-dependent epimerase/dehydratase Caul_4918 219 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167643996 Common - protein of unknown function UPF0054 Caul_0023 73 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 167646129 Common - phage SPO1 DNA polymerase-related protein Caul_2166 154 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 167646603 Common - ThiJ/PfpI domain protein Caul_2641 94 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 167644261 Common - N-acetylglucosamine-6-phosphate deacetylase Caul_0289 118 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 167648578 Common - adenosylhomocysteinase Caul_4623 177 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 167644123 Common - ROK family protein Caul_0150 138 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 167648432 Nonpathogen - Rv0623 family protein transcription factor Caul_4477 2 COG4423 COG4423, Uncharacterized protein conserved in bacteria Function unknown 167647910 Common - binding-protein-dependent transport systems inner membrane component Caul_3950 204 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 167648859 Common - Cystathionine gamma-lyase Caul_4904 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 167644490 Nonpathogen - Chorismate mutase Caul_0521 1 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 167645186 Common - transcriptional regulator, XRE family Caul_1221 37 COG1396 HipB, Predicted transcriptional regulators Transcription 167648305 Common - transcriptional regulator, MarR family Caul_4350 22 COG1846 MarR, Transcriptional regulators Transcription 167646534 Common - ribonuclease, Rne/Rng family Caul_2572 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 167647227 Common - phosphoadenosine phosphosulfate reductase Caul_3265 161 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 167645000 Nonpathogen - hypothetical protein Caul_1035 1 None None None 167645322 Common - transcriptional regulator, MucR family Caul_1357 34 COG4957 COG4957, Predicted transcriptional regulator Transcription 167644787 Common - hypothetical protein Caul_0821 8 COG3087 FtsN, Cell division protein Cell division and chromosome partitioning 167646202 Nonpathogen - hypothetical protein Caul_2240 2 None None None 167648139 Nonpathogen - hypothetical protein Caul_4180 2 None None None 167645007 Common - Activator of Hsp90 ATPase 1 family protein Caul_1042 54 COG3832 COG3832, Uncharacterized conserved protein Function unknown 167644954 Common - peptidase M20 Caul_0989 148 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 167648521 Nonpathogen - hypothetical protein Caul_4566 1 None None None 167645722 Common - 2-deoxy-D-gluconate 3-dehydrogenase Caul_1758 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167644507 Common - aldo/keto reductase Caul_0538 193 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 167644552 Common - Carboxylesterase type B Caul_0584 53 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 167644791 Common - glucose sorbosone dehydrogenase Caul_0825 125 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 167648480 Common - threonyl-tRNA synthetase Caul_4525 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 167645904 Common - short-chain dehydrogenase/reductase SDR Caul_1940 209 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 167645024 Common - acyl-CoA dehydrogenase domain protein Caul_1059 160 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167646788 Common - NADH dehydrogenase (quinone) Caul_2826 186 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 167646292 Nonpathogen - hypothetical protein Caul_2330 4 None None None 167647264 Common - MCP methyltransferase, CheR-type Caul_3302 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 167645169 Common - hypothetical protein Caul_1204 21 None None None 167645031 Common - NAD-dependent epimerase/dehydratase Caul_1066 27 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167648051 Common - tryptophan halogenase Caul_4092 16 COG1232 HemY, Protoporphyrinogen oxidase Coenzyme metabolism 167645898 Common - UspA domain protein Caul_1934 9 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 167645232 Nonpathogen - hypothetical protein Caul_1267 1 None None None 167644292 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Caul_0320 203 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 167646377 Common - Alpha-N-arabinofuranosidase Caul_2415 30 COG3534 AbfA, Alpha-L-arabinofuranosidase Carbohydrate transport and metabolism 167647484 Common - tRNA/rRNA methyltransferase (SpoU) Caul_3522 156 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 167645820 Common - hypothetical protein Caul_1856 35 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 167648257 Common - Hemerythrin HHE cation binding domain protein Caul_4302 30 None None None 167647298 Common - Na+ dependent nucleoside transporter domain protein Caul_3336 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 167645146 Common - GTP-binding protein LepA Caul_1181 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 167648583 Common - HPr kinase Caul_4628 71 COG1493 HprK, Serine kinase of the HPr protein, regulates carbohydrate metabolism Signal transduction mechanisms 167648772 Common - hypothetical protein Caul_4817 26 COG5338 COG5338, Uncharacterized protein conserved in bacteria Function unknown 167648886 Common - ABC-2 type transporter protein Caul_4931 56 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 167644914 Nonpathogen - hypothetical protein Caul_0949 2 None None None 167644968 Common - sugar transferase Caul_1003 92 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 167649017 Nonpathogen - hypothetical protein Caul_5062 1 None None None 167648487 Common - hypothetical protein Caul_4532 22 COG3788 COG3788, Uncharacterized relative of glutathione S-transferase, MAPEG superfamily General function prediction only 167644164 Common - GCN5-related N-acetyltransferase Caul_0192 75 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 167647325 Nonpathogen - hypothetical protein Caul_3363 1 None None None 167647871 Nonpathogen - hypothetical protein Caul_3911 6 None None None 167644319 Common - hypothetical protein Caul_0347 25 COG3461 COG3461, Uncharacterized conserved protein Function unknown 167646505 Common - TonB-dependent receptor Caul_2543 39 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647986 Common - transporter, hydrophobe/amphiphile efflux-1 (HAE1) family Caul_4026 178 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 167644101 Nonpathogen - hypothetical protein Caul_0128 1 None None None 167644906 Common - glutaredoxin 3 Caul_0940 131 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 167648413 Common - transcriptional regulator, AraC family Caul_4458 69 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 167648955 Common - Citrate (pro-3S)-lyase Caul_5000 111 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 167644816 Nonpathogen - pyridoxamine 5'-phosphate oxidase-related FMN-binding Caul_0850 13 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 167647586 Common - Aldehyde Dehydrogenase_ Caul_3624 166 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167644570 Common - Cobyrinic acid ac-diamide synthase Caul_0602 181 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 167645134 Common - protein of unknown function DUF983 Caul_1169 26 COG5349 COG5349, Uncharacterized protein conserved in bacteria Function unknown 167647222 Common - NUDIX hydrolase Caul_3260 7 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 167645404 Common - 6-phosphogluconolactonase Caul_1439 115 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 167645511 Common - D-galactarate dehydratase/altronate hydrolase-like protein Caul_1546 62 None None None 167646093 Common - ROK family protein Caul_2130 155 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 167648012 Common - riboflavin biosynthesis protein RibF Caul_4052 211 COG0196 RibF, FAD synthase Coenzyme metabolism 167647332 Common - AAA ATPase Caul_3370 32 COG3910 COG3910, Predicted ATPase General function prediction only 167647491 Nonpathogen - Auxin Efflux Carrier Caul_3529 1 COG0679 COG0679, Predicted permeases General function prediction only 167644374 Common - hypothetical protein Caul_0402 12 None None None 167645315 Common - GAF domain-containing protein Caul_1350 79 COG1956 COG1956, GAF domain-containing protein Signal transduction mechanisms 167648605 Common - two component transcriptional regulator, Fis family Caul_4650 169 COG4567 COG4567, Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain Signal transduction mechanisms / Transcription 167646119 Nonpathogen - hypothetical protein Caul_2156 1 None None None 167645349 Common - flagellar biosynthetic protein FlhB Caul_1384 130 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 167648027 Nonpathogen - hypothetical protein Caul_4067 1 None None None 167644742 Common - metallophosphoesterase Caul_0776 81 COG1692 COG1692, Uncharacterized protein conserved in bacteria Function unknown 167645924 Common - hypothetical protein Caul_1960 20 None None None 167645968 Common - domain of unknown function DUF1738 Caul_2005 48 COG4227 COG4227, Antirestriction protein DNA replication, recombination, and repair 167648792 Common - succinate dehydrogenase and fumarate reductase iron-sulfur protein Caul_4837 200 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 167645988 Common - TRAG family protein Caul_2025 78 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 167648898 Common - alpha/beta hydrolase fold Caul_4943 51 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167644544 Nonpathogen - hypothetical protein Caul_0576 4 None None None 167646679 Common - glycosyl transferase family 2 Caul_2717 23 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 167648205 Common - transposase IS3/IS911 family protein Caul_4249 44 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 167648020 Common - GumN family protein Caul_4060 2 None None None 167646832 Common - pantetheine-phosphate adenylyltransferase Caul_2870 209 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 167646084 Common - Hemolysin-type calcium-binding region Caul_2121 27 None None None 167647337 Nonpathogen - hypothetical protein Caul_3375 1 None None None 167647441 Nonpathogen - hypothetical protein Caul_3479 1 None None None 167645919 Common - Phosphate acetyltransferase Caul_1955 154 COG0280 Pta, Phosphotransacetylase Energy production and conversion 167644917 Common - protein of unknown function DUF6 transmembrane Caul_0952 27 None None None 167644306 Nonpathogen - hypothetical protein Caul_0334 2 None None None 167644972 Common - flagellar hook-associated protein FlgK Caul_1007 121 COG1256 FlgK, Flagellar hook-associated protein Cell motility and secretion 167646326 Common - sarcosine oxidase, alpha subunit family Caul_2364 177 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 167648537 Common - cytochrome c class I Caul_4582 56 COG3474 COG3474, Cytochrome c2 Energy production and conversion 167648662 Common - glycoside hydrolase family 16 Caul_4707 49 COG2273 SKN1, Beta-glucanase/Beta-glucan synthetase Carbohydrate transport and metabolism 167644360 Common - Dihydroorotate oxidase Caul_0388 170 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 167648942 Nonpathogen - protein of unknown function DUF6 transmembrane Caul_4987 2 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 167647691 Nonpathogen - hypothetical protein Caul_3729 1 None None None 167646071 Common - hypothetical protein Caul_2108 13 None None None 167646209 Common - hypothetical protein Caul_2247 18 COG5419 COG5419, Uncharacterized conserved protein Function unknown 167645068 Common - ISCc1, transposase OrfB Caul_1103 29 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 167648031 Common - acyl-CoA dehydrogenase domain protein Caul_4071 144 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167644060 Nonpathogen - hypothetical protein Caul_0087 1 None None None 167644451 Common - hypothetical protein Caul_0482 9 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 167647042 Common - acriflavin resistance protein Caul_3080 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 167646143 Common - Integrase catalytic region Caul_2180 90 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 167648391 Common - short-chain dehydrogenase/reductase SDR Caul_4436 69 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167647631 Common - UDP-N-acetylmuramoylalanine--D-glutamate ligase Caul_3669 211 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 167645162 Common - glycosyl transferase family 9 Caul_1197 104 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 167644395 Common - AMP-dependent synthetase and ligase Caul_0423 220 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167646686 Common - hypothetical protein Caul_2724 7 None None None 167646480 Common - 3-oxoacyl-(acyl-carrier-protein) reductase Caul_2518 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167644349 Common - protein of unknown function DUF985 Caul_0377 57 COG3542 COG3542, Uncharacterized conserved protein Function unknown 167644818 Common - integral membrane sensor hybrid histidine kinase Caul_0852 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167644089 Common - Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) Caul_0116 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 167646871 Common - polar amino acid ABC transporter, inner membrane subunit Caul_2909 174 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 167647933 Nonpathogen - hypothetical protein Caul_3973 1 None None None 167648065 Common - filamentous haemagglutinin family outer membrane protein Caul_4106 69 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 167648076 Common - RNA-binding S4 domain protein Caul_4117 64 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 167648105 Common - hypothetical protein Caul_4146 12 None None None 167648359 Common - transcriptional regulator, TetR family Caul_4404 84 COG1309 AcrR, Transcriptional regulator Transcription 167646343 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_2381 106 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167644329 Nonpathogen - hypothetical protein Caul_0357 1 COG2832 COG2832, Uncharacterized protein conserved in bacteria Function unknown 167644386 Common - cytochrome c class I Caul_0414 57 COG3474 COG3474, Cytochrome c2 Energy production and conversion 167647666 Common - protein of unknown function DUF1206 Caul_3704 25 None None None 167648731 Common - filamentation induced by cAMP protein Fic Caul_4776 98 COG3177 COG3177, Uncharacterized conserved protein Function unknown 167645329 Common - flagellar biosynthetic protein FliP Caul_1364 128 COG1338 FliP, Flagellar biosynthesis pathway, component FliP Cell motility and secretion / Intracellular trafficking and secretion 167648705 Nonpathogen - hypothetical protein Caul_4750 3 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 167647734 Nonpathogen - hypothetical protein Caul_3772 5 None None None 167649012 Common - globin Caul_5057 34 COG2346 COG2346, Truncated hemoglobins General function prediction only 167648619 Common - ABC transporter related Caul_4664 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 167644493 Common - transcriptional regulator, LysR family Caul_0524 179 COG0583 LysR, Transcriptional regulator Transcription 167645111 Nonpathogen - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_1146 1 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167644878 Common - protein of unknown function DUF1013 Caul_0912 41 COG3820 COG3820, Uncharacterized protein conserved in bacteria Function unknown 167646664 Nonpathogen - hypothetical protein Caul_2702 2 None None None 167648324 Nonpathogen - plasmid stabilization system Caul_4369 1 COG3668 ParE, Plasmid stabilization system protein General function prediction only 167648381 Common - peptidoglycan-associated lipoprotein Caul_4426 152 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 167647679 Common - guanine deaminase Caul_3717 154 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 167648513 Common - acetylglutamate kinase Caul_4558 217 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 167646690 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_2728 95 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167644868 Common - aspartate racemase Caul_0902 76 COG1794 RacX, Aspartate racemase Cell envelope biogenesis, outer membrane 167646484 Common - YicC domain protein Caul_2522 136 COG1561 COG1561, Uncharacterized stress-induced protein Function unknown 167645016 Nonpathogen - hypothetical protein Caul_1051 1 None None None 167645300 Common - efflux transporter, RND family, MFP subunit Caul_1335 149 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 167648085 Common - methylated-DNA--protein-cysteine methyltransferase Caul_4126 222 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 167646917 Common - nitrite reductase (NAD(P)H), small subunit Caul_2955 84 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 167648499 Common - phosphoribosylamine--glycine ligase Caul_4544 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 167647724 Common - signal transduction histidine kinase Caul_3762 85 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 167644599 Common - multi-sensor signal transduction histidine kinase Caul_0631 223 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 167644473 Common - TonB-dependent receptor Caul_0504 101 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647171 Common - cold-shock DNA-binding domain protein Caul_3209 178 COG1278 CspC, Cold shock proteins Transcription 167648245 Common - Glutathione S-transferase domain Caul_4290 81 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167645957 Nonpathogen - transcriptional regulator, XRE family Caul_1994 4 COG1396 HipB, Predicted transcriptional regulators Transcription 167648559 Common - AMP-dependent synthetase and ligase Caul_4604 213 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167646702 Common - ABC transporter related Caul_2740 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 167648612 Common - Hly-III family protein Caul_4657 116 COG1272 COG1272, Predicted membrane protein, hemolysin III homolog General function prediction only 167646471 Common - TonB-dependent receptor Caul_2509 103 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 167644013 Common - ribosomal protein S15 Caul_0040 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 167644709 Common - Alcohol dehydrogenase zinc-binding domain protein Caul_0743 212 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 167648957 Common - histidine triad (HIT) protein Caul_5002 58 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 167646840 Common - fatty acid desaturase Caul_2878 10 COG3239 DesA, Fatty acid desaturase Lipid metabolism 167645424 Common - MOSC domain containing protein Caul_1459 36 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 167645054 Common - transcriptional regulator, TetR family Caul_1089 69 COG1309 AcrR, Transcriptional regulator Transcription 167646016 Nonpathogen - hypothetical protein Caul_2053 2 None None None 167648560 Common - hypothetical protein Caul_4605 9 None None None 167644770 Common - translation elongation factor Tu Caul_0804 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 167646233 Common - putative conjugal transfer protein TrbE Caul_2271 61 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 167648351 Common - cyclic nucleotide-binding protein Caul_4396 28 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 167644080 Common - peptidase M16 domain protein Caul_0107 191 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 167644505 Common - hypothetical protein Caul_0536 8 None None None 167647383 Nonpathogen - hypothetical protein Caul_3421 1 None None None 167646337 Common - Aldehyde Dehydrogenase_ Caul_2375 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167644241 Nonpathogen - TonB family protein Caul_0269 1 None None None 167646055 Common - putative general secretion pathway protein H Caul_2092 8 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 167645701 Common - Ribonuclease III Caul_1737 200 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 167645731 Common - 2-keto-4-pentenoate hydratase, putative Caul_1767 39 COG3971 COG3971, 2-keto-4-pentenoate hydratase Secondary metabolites biosynthesis, transport, and catabolism 167646943 Common - putative manganese transport protein Caul_2981 101 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 167647358 Nonpathogen - hypothetical protein Caul_3396 1 COG5373 COG5373, Predicted membrane protein Function unknown 167646812 Common - carbohydrate kinase, YjeF related protein Caul_2850 214 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 167645448 Common - SNARE associated Golgi protein Caul_1483 93 COG0398 COG0398, Uncharacterized conserved protein Function unknown 167646670 Common - response regulator receiver protein Caul_2708 19 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 167648563 Common - cytochrome c class I Caul_4608 62 COG3474 COG3474, Cytochrome c2 Energy production and conversion 167647519 Common - prevent-host-death family protein Caul_3557 18 None None None 167645422 Nonpathogen - hypothetical protein Caul_1457 2 COG2944 COG2944, Predicted transcriptional regulator Transcription 167647213 Common - Tannase and feruloyl esterase Caul_3251 20 None None None 167644566 Common - DNA-cytosine methyltransferase Caul_0598 124 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 167644561 Common - Feruloyl esterase Caul_0593 20 COG2267 PldB, Lysophospholipase Lipid metabolism 167644483 Common - Saccharopine dehydrogenase Caul_0514 46 COG3268 COG3268, Uncharacterized conserved protein Function unknown 167648070 Common - glutathione-dependent formaldehyde-activating GFA Caul_4111 49 COG3791 COG3791, Uncharacterized conserved protein Function unknown 167646955 Nonpathogen - hypothetical protein Caul_2993 3 COG3555 COG3555, Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases Posttranslational modification, protein turnover, chaperones 167644288 Common - protein of unknown function DUF6 transmembrane Caul_0316 11 COG2510 COG2510, Predicted membrane protein Function unknown 167647612 Common - Rieske (2Fe-2S) domain protein Caul_3650 42 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 167645088 Common - transcriptional regulator, AsnC family Caul_1123 147 COG1522 Lrp, Transcriptional regulators Transcription 167648730 Common - filamentation induced by cAMP protein Fic Caul_4775 11 COG3177 COG3177, Uncharacterized conserved protein Function unknown 167647373 Common - hypothetical protein Caul_3411 23 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 167646040 Common - ABC transporter related Caul_2077 246 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 167648372 Nonpathogen - hypothetical protein Caul_4417 1 None None None 167649020 Common - transcriptional regulator, TetR family Caul_5065 92 COG1309 AcrR, Transcriptional regulator Transcription 167644199 Common - major facilitator superfamily MFS_1 Caul_0227 209 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 167648340 Nonpathogen - hypothetical protein Caul_4385 1 None None None 167648492 Common - protein tyrosine/serine phosphatase Caul_4537 13 COG2365 COG2365, Protein tyrosine/serine phosphatase Signal transduction mechanisms 167648398 Common - preprotein translocase, SecE subunit Caul_4443 35 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 167647391 Common - Abortive infection protein Caul_3429 27 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 167647572 Common - hypothetical protein Caul_3610 5 None None None 167646933 Common - Poly-beta-hydroxybutyrate polymerase domain protein Caul_2971 74 COG3243 PhaC, Poly(3-hydroxyalkanoate) synthetase Lipid metabolism 167647966 Common - transcriptional regulator, TetR family Caul_4006 98 COG1309 AcrR, Transcriptional regulator Transcription 167645497 Nonpathogen - hypothetical protein Caul_1532 1 None None None 167648788 Common - protein of unknown function DUF1025 Caul_4833 32 COG3824 COG3824, Uncharacterized protein conserved in bacteria Function unknown 167646216 Common - IstB domain protein ATP-binding protein Caul_2254 101 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 167646791 Nonpathogen - hypothetical protein Caul_2829 1 None None None 167644103 Common - acyl-CoA dehydrogenase domain protein Caul_0130 164 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167646270 Common - hypothetical protein Caul_2308 20 None None None 167646923 Common - amino acid permease-associated region Caul_2961 165 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 167647840 Common - GCN5-related N-acetyltransferase Caul_3879 27 COG0456 RimI, Acetyltransferases General function prediction only 167647034 Common - GCN5-related N-acetyltransferase Caul_3072 3 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 167645362 Nonpathogen - alanyl-tRNA synthetase Caul_1397 1 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 167647644 Common - FAD dependent oxidoreductase Caul_3682 66 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 167647486 Nonpathogen - hypothetical protein Caul_3524 2 None None None 167648362 Common - aminoglycoside phosphotransferase Caul_4407 60 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 167644658 Common - GCN5-related N-acetyltransferase Caul_0690 82 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 167648971 Common - uroporphyrinogen decarboxylase Caul_5016 174 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 167644414 Common - Enoyl-CoA hydratase/isomerase Caul_0442 65 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 167646018 Nonpathogen - hypothetical protein Caul_2055 1 None None None 167647868 Nonpathogen - hypothetical protein Caul_3908 1 None None None 167646319 Common - PepSY-associated TM helix Caul_2357 14 None None None 167647678 Common - Inosine/uridine-preferring nucleoside hydrolase Caul_3716 88 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 167647999 Common - ferrous iron transport protein B Caul_4039 163 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 167644925 Common - Alpha/beta hydrolase fold-3 domain protein Caul_0960 93 COG0657 Aes, Esterase/lipase Lipid metabolism 167645831 Nonpathogen - hypothetical protein Caul_1867 1 None None None 167644210 Common - integrase family protein Caul_0238 225 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 167645379 Common - phosphate transporter Caul_1414 166 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 167646610 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_2648 95 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167646466 Common - DNA repair protein RadA Caul_2504 219 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 167644488 Common - Gamma-glutamyltransferase Caul_0519 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 167647594 Common - addiction module toxin, RelE/StbE family Caul_3632 34 COG3668 ParE, Plasmid stabilization system protein General function prediction only 167648716 Common - protein of unknown function YGGT Caul_4761 47 COG0762 COG0762, Predicted integral membrane protein Function unknown 167647054 Common - hypothetical protein Caul_3092 123 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 167646600 Common - protein of unknown function DUF404 Caul_2638 89 COG2308 COG2308, Uncharacterized conserved protein Function unknown 167647654 Common - acyltransferase 3 Caul_3692 27 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 167644223 Common - protein of unknown function DUF1130 Caul_0251 20 COG5483 COG5483, Uncharacterized conserved protein Function unknown 167645584 Common - ribosomal protein S3 Caul_1620 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 167648316 Nonpathogen - hypothetical protein Caul_4361 1 None None None 167645276 Common - pyridoxamine 5'-phosphate oxidase Caul_1311 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 167646171 Common - phenylalanine-4-hydroxylase Caul_2208 45 COG3186 COG3186, Phenylalanine-4-hydroxylase Amino acid transport and metabolism 167644332 Common - hypothetical protein Caul_0360 14 COG4461 LprI, Uncharacterized protein conserved in bacteria, putative lipoprotein Function unknown 167645022 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Caul_1057 12 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 167646698 Common - L-threonine-O-3-phosphate decarboxylase Caul_2736 188 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 167644882 Common - Excinuclease ABC C subunit domain protein Caul_0916 45 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 167646192 Common - integrase family protein Caul_2230 207 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 167648280 Common - transcriptional regulator, PadR-like family Caul_4325 61 COG1695 COG1695, Predicted transcriptional regulators Transcription 167645526 Common - conserved hypothetical phage tail protein Caul_1561 24 None None None 167646109 Common - hypothetical protein Caul_2146 11 None None None 167648580 Common - biotin synthase Caul_4625 175 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 167646825 Common - Carboxylesterase type B Caul_2863 70 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 167646963 Common - transcriptional regulator, MerR family Caul_3001 33 COG0789 SoxR, Predicted transcriptional regulators Transcription 167646102 Nonpathogen - hypothetical protein Caul_2139 1 None None None 167647783 Common - protein of unknown function DUF736 Caul_3822 26 COG5489 COG5489, Uncharacterized conserved protein Function unknown 167645598 Common - preprotein translocase, SecY subunit Caul_1634 227 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 167647466 Nonpathogen - hypothetical protein Caul_3504 1 None None None 167644944 Common - hypothetical protein Caul_0979 33 COG3812 COG3812, Uncharacterized protein conserved in bacteria Function unknown 167648860 Nonpathogen - hypothetical protein Caul_4905 3 COG3668 ParE, Plasmid stabilization system protein General function prediction only 167644278 Common - PfkB domain protein Caul_0306 17 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 167646766 Common - translation elongation factor Ts Caul_2804 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 167644339 Common - protein of unknown function DUF661 Caul_0367 17 COG3801 COG3801, Uncharacterized protein conserved in bacteria Function unknown 167647599 Common - hypothetical protein Caul_3637 23 COG3743 COG3743, Uncharacterized conserved protein Function unknown 167646637 Nonpathogen - hypothetical protein Caul_2675 1 None None None 167646648 Nonpathogen - hypothetical protein Caul_2686 1 None None None 167647570 Common - FMN-dependent alpha-hydroxy acid dehydrogenase Caul_3608 116 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 167647336 Common - methyltransferase FkbM family Caul_3374 40 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 167646859 Common - UspA domain protein Caul_2897 18 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 167648055 Common - secretion protein HlyD family protein Caul_4096 92 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 167646031 Common - transcriptional regulator, LuxR family Caul_2068 126 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 167646519 Common - aspartyl-tRNA synthetase Caul_2557 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 167644416 Common - iron-containing alcohol dehydrogenase Caul_0444 48 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 167647426 Common - BolA family protein Caul_3464 86 COG0271 BolA, Stress-induced morphogen (activity unknown) Signal transduction mechanisms 167644170 Common - Biopolymer transport protein ExbD/TolR Caul_0198 64 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 167647681 Common - xanthine dehydrogenase, molybdopterin binding subunit Caul_3719 106 COG4631 XdhB, Xanthine dehydrogenase, molybdopterin-binding subunit B Nucleotide transport and metabolism 167644173 Common - monofunctional biosynthetic peptidoglycan transglycosylase Caul_0201 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 167647926 Common - transposase IS116/IS110/IS902 family protein Caul_3966 63 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646461 Common - Thioredoxin-disulfide reductase Caul_2499 247 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 167647209 Common - AMP-dependent synthetase and ligase Caul_3247 211 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167648535 Common - Prephenate dehydratase Caul_4580 209 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 167646800 Common - luciferase family protein Caul_2838 111 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 167647086 Common - deoxyguanosinetriphosphate triphosphohydrolase Caul_3124 162 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 167647253 Common - hypothetical protein Caul_3291 32 None None None 167644219 Common - Phytanoyl-CoA dioxygenase Caul_0247 14 COG5285 COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin Secondary metabolites biosynthesis, transport, and catabolism 167645223 Common - hypothetical protein Caul_1258 15 COG5330 COG5330, Uncharacterized protein conserved in bacteria Function unknown 167647286 Common - transglutaminase domain protein Caul_3324 76 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 167648022 Common - DNA mismatch repair protein MutL Caul_4062 191 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 167648573 Common - aspartate-semialdehyde dehydrogenase Caul_4618 231 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 167648335 Common - H+transporting two-sector ATPase B/B' subunit Caul_4380 22 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 167645419 Common - DEAD/H associated domain protein Caul_1454 223 COG1201 Lhr, Lhr-like helicases General function prediction only 167645794 Nonpathogen - hypothetical protein Caul_1830 1 None None None 167647989 Common - protein of unknown function DUF1470 Caul_4029 31 COG5516 COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding General function prediction only 167646641 Common - transcriptional regulator, TetR family Caul_2679 45 COG1309 AcrR, Transcriptional regulator Transcription 167645912 Common - RND efflux system, outer membrane lipoprotein, NodT family Caul_1948 115 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 167647790 Common - conjugal transfer protein TrbB Caul_3829 22 COG5268 TrbD, Type IV secretory pathway, TrbD component Cell motility and secretion / Intracellular trafficking and secretion 167647569 Common - Gluconate 2-dehydrogenase (acceptor) Caul_3607 53 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 167645543 Common - ABC transporter related Caul_1578 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 167648234 Common - Saccharopine dehydrogenase Caul_4278 44 COG3268 COG3268, Uncharacterized conserved protein Function unknown 167647195 Nonpathogen - hypothetical protein Caul_3233 1 None None None 167647639 Common - prevent-host-death family protein Caul_3677 23 COG4118 Phd, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 167646618 Common - transcriptional regulator, LysR family Caul_2656 181 COG0583 LysR, Transcriptional regulator Transcription 167645113 Nonpathogen - hypothetical protein Caul_1148 5 None None None 167645355 Common - protein of unknown function DUF885 Caul_1390 44 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 167648778 Common - type I secretion outer membrane protein, TolC family Caul_4823 131 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 167645179 Common - heat shock protein Hsp20 Caul_1214 75 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 167644835 Common - hypothetical protein Caul_0869 11 COG4190 COG4190, Predicted transcriptional regulator Transcription 167648620 Common - secretion protein HlyD family protein Caul_4665 78 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 167645192 Nonpathogen - hypothetical protein Caul_1227 1 None None None 167647787 Common - hypothetical protein Caul_3826 23 None None None 167644542 Common - transcriptional regulator, LysR family Caul_0574 164 COG0583 LysR, Transcriptional regulator Transcription 167647404 Common - protein of unknown function DUF1476 Caul_3442 27 COG5467 COG5467, Uncharacterized conserved protein Function unknown 167645567 Common - protein of unknown function DUF423 Caul_1603 61 COG2363 COG2363, Uncharacterized small membrane protein Function unknown 167644007 Nonpathogen - hypothetical protein Caul_0034 1 None None None 167644434 Common - HipA domain protein Caul_0465 55 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 167648865 Common - glucose-1-phosphate thymidylyltransferase Caul_4910 235 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 167646770 Common - DNA polymerase III, alpha subunit Caul_2808 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 167644636 Common - transposase and inactivated derivatives-like protein Caul_0668 46 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646903 Common - fatty acid desaturase Caul_2941 16 COG3239 DesA, Fatty acid desaturase Lipid metabolism 167644002 Common - Inorganic diphosphatase Caul_0029 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 167648043 Common - branched-chain amino acid aminotransferase Caul_4084 204 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 167646360 Common - short-chain dehydrogenase/reductase SDR Caul_2398 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167646396 Common - phosphoesterase PA-phosphatase related Caul_2434 45 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 167646852 Common - Tetratricopeptide TPR_2 repeat protein Caul_2890 90 COG0457 NrfG, FOG: TPR repeat General function prediction only 167644675 Common - conserved hypothetical protein-like protein Caul_0707 63 COG3034 COG3034, Uncharacterized protein conserved in bacteria Function unknown 167646149 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Caul_2186 136 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 167647381 Common - hypothetical protein Caul_3419 14 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 167646498 Nonpathogen - hypothetical protein Caul_2536 2 None None None 167648944 Common - heme exporter protein CcmA Caul_4989 232 COG4133 CcmA, ABC-type transport system involved in cytochrome c biogenesis, ATPase component Posttranslational modification, protein turnover, chaperones 167648220 Common - Excinuclease ABC C subunit domain protein Caul_4264 33 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 167648966 Common - DNA polymerase III, epsilon subunit Caul_5011 186 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 167646329 Common - transcriptional regulator, AraC family Caul_2367 139 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 167644905 Common - phosphoribosyltransferase Caul_0939 167 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 167644988 Common - ATPase, FliI/YscN family Caul_1023 247 COG1157 FliI, Flagellar biosynthesis/type III secretory pathway ATPase Cell motility and secretion / Intracellular trafficking and secretion 167648408 Common - binding-protein-dependent transport systems inner membrane component Caul_4453 145 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 167645868 Common - Enoyl-CoA hydratase/isomerase Caul_1904 174 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 167646595 Common - copper-translocating P-type ATPase Caul_2633 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 167648093 Common - putative transposase Caul_4134 31 COG3677 COG3677, Transposase and inactivated derivatives DNA replication, recombination, and repair 167645051 Common - RND efflux system, outer membrane lipoprotein, NodT family Caul_1086 111 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 167646866 Common - Beta-ketoacyl-acyl-carrier-protein synthase I Caul_2904 204 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 167648238 Nonpathogen - hypothetical protein Caul_4282 1 None None None 167644723 Common - protein of unknown function DUF692 Caul_0757 62 COG3220 COG3220, Uncharacterized protein conserved in bacteria Function unknown 167644656 Common - short-chain dehydrogenase/reductase SDR Caul_0688 212 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167644690 Common - Shikimate kinase Caul_0722 199 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 167645900 Common - hypothetical protein Caul_1936 3 None None None 167647233 Common - Chorismate mutase Caul_3271 31 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 167644047 Common - hypothetical protein Caul_0074 17 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 167648126 Common - hypothetical protein Caul_4167 15 None None None 167647802 Common - hypothetical protein Caul_3841 9 None None None 167645467 Common - ribonuclease R Caul_1502 192 COG0557 VacB, Exoribonuclease R Transcription 167649003 Common - endonuclease III Caul_5048 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 167644712 Common - Inositol-phosphate phosphatase Caul_0746 211 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 167645125 Nonpathogen - hypothetical protein Caul_1160 1 None None None 167645148 Common - transglutaminase domain protein Caul_1183 64 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 167648978 Common - tRNA modification GTPase TrmE Caul_5023 217 COG0486 ThdF, Predicted GTPase General function prediction only 167646683 Nonpathogen - Xylose isomerase domain protein TIM barrel Caul_2721 9 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 167646755 Common - acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase Caul_2793 151 COG1043 LpxA, Acyl- acyl carrier protein 167644372 Nonpathogen - hypothetical protein Caul_0400 2 None None None 167646436 Common - efflux transporter, RND family, MFP subunit Caul_2474 48 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 167644618 Common - NAD-dependent epimerase/dehydratase Caul_0650 40 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167645170 Common - hypothetical protein Caul_1205 22 None None None 167645216 Nonpathogen - hypothetical protein Caul_1251 2 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 167645029 Common - Rieske (2Fe-2S) domain protein Caul_1064 79 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 167646787 Nonpathogen - hypothetical protein Caul_2825 1 None None None 167646272 Nonpathogen - hypothetical protein Caul_2310 1 None None None 167648852 Common - thioesterase superfamily protein Caul_4897 21 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 167644346 Common - amino acid/peptide transporter Caul_0374 80 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 167646241 Nonpathogen - hypothetical protein Caul_2279 3 None None None 167646022 Common - protein of unknown function DUF808 Caul_2059 60 COG2354 COG2354, Uncharacterized protein conserved in bacteria Function unknown 167646183 Common - hypothetical protein Caul_2220 4 None None None 167646140 Common - methyl-accepting chemotaxis sensory transducer Caul_2177 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 167647290 Common - Glu/Leu/Phe/Val dehydrogenase dimerisation region Caul_3328 112 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 167647154 Nonpathogen - hypothetical protein Caul_3192 1 None None None 167646029 Common - hypothetical protein Caul_2066 6 None None None 167644805 Common - protein of unknown function DUF450 Caul_0839 34 COG4748 COG4748, Uncharacterized conserved protein Function unknown 167647729 Common - binding-protein-dependent transport systems inner membrane component Caul_3767 145 COG2011 AbcD, ABC-type metal ion transport system, permease component Inorganic ion transport and metabolism 167646191 Common - integrase family protein Caul_2229 119 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 167646386 Common - integral membrane sensor signal transduction histidine kinase Caul_2424 214 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167647958 Common - NAD-dependent epimerase/dehydratase Caul_3998 71 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167648193 Common - K potassium transporter Caul_4236 88 COG3158 Kup, K+ transporter Inorganic ion transport and metabolism 167646697 Common - TonB-dependent receptor Caul_2735 118 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 167648225 Common - putative transmembrane anti-sigma factor Caul_4269 6 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 167645641 Common - hypothetical protein Caul_1677 37 None None None 167646350 Common - alkylhydroperoxidase like protein, AhpD family Caul_2388 79 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 167646726 Common - ribosomal protein L32 Caul_2764 23 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 167646038 Common - major facilitator superfamily MFS_1 Caul_2075 102 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 167646401 Nonpathogen - Cbb3-type cytochrome oxidase component Caul_2439 4 COG4736 CcoQ, Cbb3-type cytochrome oxidase, subunit 3 Posttranslational modification, protein turnover, chaperones 167646567 Common - signal transduction histidine kinase, nitrogen specific, NtrB Caul_2605 219 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 167644748 Common - Inosine/uridine-preferring nucleoside hydrolase Caul_0782 81 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 167648176 Nonpathogen - HdeD protein Caul_4217 1 COG3247 HdeD, Uncharacterized conserved protein Function unknown 167648307 Common - integral membrane sensor signal transduction histidine kinase Caul_4352 214 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167644098 Common - 3-hydroxyacyl-CoA dehydrogenase NAD-binding Caul_0125 173 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 167645547 Nonpathogen - hypothetical protein Caul_1582 5 COG3729 GsiB, General stress protein General function prediction only 167647277 Common - Polyprenyl synthetase Caul_3315 242 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 167644526 Nonpathogen - hypothetical protein Caul_0558 2 None None None 167646262 Common - transcriptional regulator, MerR family Caul_2300 113 COG0789 SoxR, Predicted transcriptional regulators Transcription 167646717 Common - dihydrolipoamide dehydrogenase Caul_2755 245 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 167646747 Common - ComEC/Rec2-related protein Caul_2785 67 COG0658 ComEC, Predicted membrane metal-binding protein General function prediction only 167645351 Common - hypothetical protein Caul_1386 7 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 167646499 Common - ABC transporter related Caul_2537 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 167648374 Common - band 7 protein Caul_4419 218 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 167645741 Nonpathogen - prevent-host-death family protein Caul_1777 5 COG4118 Phd, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 167647628 Common - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Caul_3666 208 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 167648796 Common - hypothetical protein Caul_4841 16 None None None 167648802 Common - hypothetical protein Caul_4847 2 None None None 167644146 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Caul_0174 207 COG0313 COG0313, Predicted methyltransferases General function prediction only 167644464 Common - AMP-dependent synthetase and ligase Caul_0495 222 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167646100 Common - TonB-dependent receptor Caul_2137 27 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647028 Common - beta-lactamase Caul_3066 130 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 167644763 Common - Glutathione S-transferase domain Caul_0797 104 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167645484 Common - glutamyl-tRNA(Gln) amidotransferase, C subunit Caul_1519 149 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 167646655 Nonpathogen - hypothetical protein Caul_2693 1 None None None 167647720 Common - hypothetical protein Caul_3758 37 None None None 167648500 Common - acyltransferase 3 Caul_4545 22 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 167644862 Nonpathogen - hypothetical protein Caul_0896 7 None None None 167645885 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Caul_1921 21 None None None 167645151 Nonpathogen - hypothetical protein Caul_1186 1 None None None 167648396 Common - Orn/DAP/Arg decarboxylase 2 Caul_4441 80 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 167647070 Common - protein-export membrane protein SecD Caul_3108 206 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 167644024 Common - transcriptional regulator, LuxR family Caul_0051 3 COG2771 CsgD, DNA-binding HTH domain-containing proteins Transcription 167646589 Common - sulphate transporter Caul_2627 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 167644309 Common - hypothetical protein Caul_0337 32 None None None 167645098 Common - Aldehyde Dehydrogenase_ Caul_1133 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167646172 Common - hemimethylated DNA binding protein Caul_2209 35 COG3785 COG3785, Uncharacterized conserved protein Function unknown 167646049 Nonpathogen - outer membrane chaperone Skp (OmpH) Caul_2086 6 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 167647761 Nonpathogen - hypothetical protein Caul_3800 1 None None None 167648240 Common - Patatin Caul_4284 11 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 167645853 Common - TonB-dependent receptor Caul_1889 61 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167644624 Common - Pyridoxal-5'-phosphate-dependent protein beta subunit Caul_0656 204 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 167648464 Common - hypothetical protein Caul_4509 28 None None None 167644093 Common - hypothetical protein Caul_0120 6 COG4223 COG4223, Uncharacterized protein conserved in bacteria Function unknown 167646445 Common - transcriptional regulator, GntR family with aminotransferase domain Caul_2483 155 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 167645637 Nonpathogen - hypothetical protein Caul_1673 4 COG5571 COG5571, Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion Cell motility and secretion 167647527 Common - ABC transporter related Caul_3565 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 167647891 Common - acriflavin resistance protein Caul_3931 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 167646132 Common - 4-diphosphocytidyl-2C-methyl-D-erythritol kinase Caul_2169 67 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 167647886 Common - K potassium transporter Caul_3926 88 COG3158 Kup, K+ transporter Inorganic ion transport and metabolism 167648692 Common - ATP synthase F1, beta subunit Caul_4737 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 167644259 Nonpathogen - CheE protein Caul_0287 1 None None None 167644663 Common - Polynucleotide adenylyltransferase region Caul_0695 193 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 167648125 Nonpathogen - hypothetical protein Caul_4166 2 None None None 167645630 Common - transcriptional regulator, XRE family Caul_1666 73 COG1476 COG1476, Predicted transcriptional regulators Transcription 167646520 Common - pentapeptide repeat protein Caul_2558 105 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 167647833 Common - oxygen-independent coproporphyrinogen III oxidase Caul_3872 201 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 167643988 Common - peptidase M22 glycoprotease Caul_0015 180 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 167644203 Common - 2-oxoglutarate dehydrogenase, E1 subunit Caul_0231 147 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 167645206 Common - signal transduction histidine kinase Caul_1241 72 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 167648656 Common - 3-oxoacid CoA-transferase, A subunit Caul_4701 102 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 167646007 Common - hypothetical protein Caul_2044 46 COG3577 COG3577, Predicted aspartyl protease General function prediction only 167648212 Common - hypothetical protein Caul_4256 9 None None None 167648740 Nonpathogen - hypothetical protein Caul_4785 2 None None None 167644685 Common - response regulator receiver protein Caul_0717 22 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 167644869 Common - phosphoribosylaminoimidazole carboxylase, ATPase subunit Caul_0903 193 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 167645762 Nonpathogen - glyoxalase/bleomycin resistance protein/dioxygenase Caul_1798 2 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 167648134 Nonpathogen - hypothetical protein Caul_4175 1 None None None 167646300 Common - hypothetical protein Caul_2338 5 None None None 167644444 Nonpathogen - hypothetical protein Caul_0475 1 None None None 167644844 Nonpathogen - hypothetical protein Caul_0878 1 None None None 167645842 Common - HpcH/HpaI aldolase Caul_1878 98 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 167647091 Nonpathogen - hypothetical protein Caul_3129 1 None None None 167648453 Common - threonine synthase Caul_4498 169 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 167648166 Nonpathogen - hypothetical protein Caul_4207 1 None None None 167644858 Common - NAD(P) transhydrogenase, alpha2 subunit Caul_0892 96 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 167647113 Common - Carbamoyl-phosphate synthase L chain ATP-binding Caul_3151 230 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 167648891 Common - Nucleotidyl transferase Caul_4936 224 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 167645593 Common - ribosomal protein L6 Caul_1629 241 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 167644355 Common - Endonuclease/exonuclease/phosphatase Caul_0383 80 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 167647556 Common - Ethyl tert-butyl ether degradation EthD Caul_3594 19 None None None 167648477 Common - glycosyl transferase family 39 Caul_4522 41 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 167644027 Nonpathogen - hypothetical protein Caul_0054 1 None None None 167648081 Common - hypothetical protein Caul_4122 44 COG1204 COG1204, Superfamily II helicase General function prediction only 167644994 Common - hypothetical protein Caul_1029 6 None None None 167645710 Nonpathogen - hypothetical protein Caul_1746 1 None None None 167646338 Common - FAD dependent oxidoreductase Caul_2376 111 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 167645370 Common - glutathionylspermidine synthase Caul_1405 54 COG0754 Gsp, Glutathionylspermidine synthase Amino acid transport and metabolism 167646779 Common - putative transcriptional acitvator, Baf family Caul_2817 135 COG1521 COG1521, Putative transcriptional regulator, homolog of Bvg accessory factor Transcription 167645982 Nonpathogen - protein of unknown function DUF433 Caul_2019 3 COG2442 COG2442, Uncharacterized conserved protein Function unknown 167647276 Common - deoxyxylulose-5-phosphate synthase Caul_3314 228 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 167649008 Nonpathogen - hypothetical protein Caul_5053 1 None None None 167648644 Nonpathogen - hypothetical protein Caul_4689 1 None None None 167645737 Common - Ku protein Caul_1773 63 COG1273 COG1273, Uncharacterized conserved protein Function unknown 167644264 Common - TonB-dependent receptor Caul_0292 39 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167645625 Common - O-succinylhomoserine sulfhydrylase Caul_1661 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 167645311 Common - MaoC domain protein dehydratase Caul_1346 61 COG2030 MaoC, Acyl dehydratase Lipid metabolism 167647921 Common - Chorismate synthase Caul_3961 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 167645450 Common - 2-isopropylmalate synthase Caul_1485 213 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 167645560 Common - O-antigen polymerase Caul_1595 24 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 167644697 Common - HpcH/HpaI aldolase Caul_0731 109 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 167648641 Nonpathogen - hypothetical protein Caul_4686 1 None None None 167646331 Common - major facilitator superfamily MFS_1 Caul_2369 44 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167648906 Common - glutamate synthase, small subunit Caul_4951 188 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 167644052 Common - signal transduction histidine kinase Caul_0079 100 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 167648757 Common - glycoside hydrolase family 16 Caul_4802 113 COG2273 SKN1, Beta-glucanase/Beta-glucan synthetase Carbohydrate transport and metabolism 167644898 Common - signal transduction histidine kinase Caul_0932 151 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 167648750 Common - amine oxidase Caul_4795 38 COG1232 HemY, Protoporphyrinogen oxidase Coenzyme metabolism 167646710 Common - diguanylate cyclase Caul_2748 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 167645233 Common - Mandelate racemase/muconate lactonizing protein Caul_1268 94 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 167646248 Common - heavy metal efflux pump, CzcA family Caul_2286 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 167648503 Common - phosphate ABC transporter, ATPase subunit Caul_4548 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 167647757 Nonpathogen - hypothetical protein Caul_3796 2 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 167644254 Common - response regulator receiver modulated CheB methylesterase Caul_0282 209 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 167645648 Nonpathogen - hypothetical protein Caul_1684 12 None None None 167646255 Nonpathogen - hypothetical protein Caul_2293 1 None None None 167646286 Common - heavy metal efflux pump, CzcA family Caul_2324 177 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 167647252 Common - putative D-(-)-3-hydroxybutyrate oligomer hydrolase Caul_3290 9 None None None 167645061 Nonpathogen - hypothetical protein Caul_1096 2 None None None 167647266 Common - CheW protein Caul_3304 125 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 167645802 Common - TonB-dependent receptor Caul_1838 32 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 167646738 Common - glutamine amidotransferase of anthranilate synthase Caul_2776 239 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 167645399 Common - flagellar motor switch protein FliM Caul_1434 107 COG1868 FliM, Flagellar motor switch protein Cell motility and secretion 167646733 Common - anthranilate synthase component I Caul_2771 221 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 167648216 Common - glycerophosphoryl diester phosphodiesterase Caul_4260 97 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 167645255 Common - tryptophan halogenase Caul_1290 16 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 167644293 Common - TonB-dependent receptor Caul_0321 30 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167644233 Common - phosphonate ABC transporter, inner membrane subunit Caul_0261 143 COG3639 COG3639, ABC-type phosphate/phosphonate transport system, permease component Inorganic ion transport and metabolism 167644076 Common - ribosomal protein S1 Caul_0103 213 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 167644083 Nonpathogen - cyclase/dehydrase Caul_0110 6 None None None 167647776 Common - hypothetical protein Caul_3815 11 COG5419 COG5419, Uncharacterized conserved protein Function unknown 167648765 Common - periplasmic protein-like protein Caul_4810 16 COG3672 COG3672, Predicted periplasmic protein Function unknown 167646455 Nonpathogen - hypothetical protein Caul_2493 1 None None None 167647747 Common - oxidoreductase domain protein Caul_3785 177 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 167644603 Common - cytochrome d ubiquinol oxidase, subunit II Caul_0635 155 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 167645085 Common - TonB-dependent receptor Caul_1120 112 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 167644668 Common - tRNA/rRNA methyltransferase (SpoU) Caul_0700 157 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 167647354 Common - acyl-CoA dehydrogenase domain protein Caul_3392 142 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167646157 Common - sulfate ABC transporter, inner membrane subunit CysW Caul_2194 191 COG4208 CysW, ABC-type sulfate transport system, permease component Inorganic ion transport and metabolism 167647077 Common - seryl-tRNA synthetase Caul_3115 243 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 167645720 Common - Glucuronate isomerase Caul_1756 59 COG1904 UxaC, Glucuronate isomerase Carbohydrate transport and metabolism 167647071 Common - preprotein translocase, YajC subunit Caul_3109 162 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 167647461 Common - hypothetical protein Caul_3499 21 None None None 167645578 Common - ribosomal protein L3 Caul_1614 218 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 167647772 Common - hypothetical protein Caul_3811 11 None None None 167647823 Common - major facilitator superfamily MFS_1 Caul_3862 78 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 167648781 Common - protein of unknown function DUF6 transmembrane Caul_4826 93 COG2510 COG2510, Predicted membrane protein Function unknown 167646299 Common - protein of unknown function DUF1622 Caul_2337 17 COG4828 COG4828, Predicted membrane protein Function unknown 167646066 Common - anti-FecI sigma factor, FecR Caul_2103 40 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 167648088 Common - hypothetical protein Caul_4129 7 None None None 167647267 Common - methyl-accepting chemotaxis sensory transducer Caul_3305 17 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 167644172 Common - nitroreductase Caul_0200 46 COG0778 NfnB, Nitroreductase Energy production and conversion 167648273 Common - ThiJ/PfpI domain protein Caul_4318 75 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 167645109 Nonpathogen - hypothetical protein Caul_1144 2 None None None 167647760 Nonpathogen - hypothetical protein Caul_3799 1 None None None 167648083 Common - PilT protein domain protein Caul_4124 35 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 167646302 Common - Aldehyde Dehydrogenase_ Caul_2340 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167644358 Common - putative phosphohistidine phosphatase, SixA Caul_0386 78 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 167644021 Common - siroheme synthase Caul_0048 77 COG1648 CysG, Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) Coenzyme metabolism 167648226 Nonpathogen - protein of unknown function DUF1078 domain protein Caul_4270 1 COG1749 FlgE, Flagellar hook protein FlgE Cell motility and secretion 167648135 Common - hypothetical protein Caul_4176 29 None None None 167648123 Common - type I secretion membrane fusion protein, HlyD family Caul_4164 133 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 167646663 Common - zinc finger SWIM domain protein Caul_2701 11 COG4715 COG4715, Uncharacterized conserved protein Function unknown 167644749 Nonpathogen - hypothetical protein Caul_0783 1 None None None 167646073 Common - filamentous haemagglutinin family outer membrane protein Caul_2110 75 None None None 167645869 Common - major facilitator superfamily MFS_1 Caul_1905 205 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167645396 Common - flagellar basal-body rod protein FlgG Caul_1431 126 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 167645691 Common - DNA-directed RNA polymerase, omega subunit Caul_1727 115 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 167646550 Common - FeS assembly protein SufB Caul_2588 184 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 167647330 Common - GCN5-related N-acetyltransferase Caul_3368 4 COG1444 COG1444, Predicted P-loop ATPase fused to an acetyltransferase General function prediction only 167648098 Nonpathogen - hypothetical protein Caul_4139 1 None None None 167644079 Common - hypothetical protein Caul_0106 109 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 167646460 Common - small GTP-binding protein Caul_2498 237 COG1160 COG1160, Predicted GTPases General function prediction only 167646245 Nonpathogen - hypothetical protein Caul_2283 1 None None None 167645764 Common - Taurine catabolism dioxygenase TauD/TfdA Caul_1800 47 COG2175 TauD, Probable taurine catabolism dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 167645282 Nonpathogen - hypothetical protein Caul_1317 1 None None None 167646127 Common - transposase IS116/IS110/IS902 family protein Caul_2164 63 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 167644933 Common - TonB-dependent receptor Caul_0968 82 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647718 Common - 7-cyano-7-deazaguanine reductase Caul_3756 143 COG0780 COG0780, Enzyme related to GTP cyclohydrolase I General function prediction only 167644180 Common - protein of unknown function DUF1232 Caul_0208 26 COG3339 COG3339, Uncharacterized conserved protein Function unknown 167644151 Common - Mg chelatase, subunit ChlI Caul_0179 187 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 167648867 Common - dTDP-glucose 4,6-dehydratase Caul_4912 232 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 167645645 Common - metallophosphoesterase Caul_1681 70 COG1409 Icc, Predicted phosphohydrolases General function prediction only 167645208 Nonpathogen - hypothetical protein Caul_1243 2 None None None 167647794 Common - P-type conjugative transfer protein TrbL Caul_3833 30 COG3846 TrbL, Type IV secretory pathway, TrbL components Intracellular trafficking and secretion 167645339 Nonpathogen - hypothetical protein Caul_1374 1 None None None 167644324 Common - transcriptional modulator of MazE/toxin, MazF Caul_0352 26 COG2337 MazF, Growth inhibitor Signal transduction mechanisms 167646736 Common - protein of unknown function DUF1130 Caul_2774 44 COG5483 COG5483, Uncharacterized conserved protein Function unknown 167646335 Common - protein of unknown function DUF885 Caul_2373 44 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 167647389 Common - acyl-CoA dehydrogenase domain protein Caul_3427 147 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167644802 Common - methylmalonyl-CoA mutase, large subunit Caul_0836 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 167646990 Common - cytochrome oxidase assembly Caul_3028 53 COG1612 CtaA, Uncharacterized protein required for cytochrome oxidase assembly Posttranslational modification, protein turnover, chaperones 167644866 Common - ribosomal protein S21 Caul_0900 42 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 167645365 Common - hypothetical protein Caul_1400 22 COG5463 COG5463, Predicted integral membrane protein Function unknown 167647397 Common - Activator of Hsp90 ATPase 1 family protein Caul_3435 15 COG3832 COG3832, Uncharacterized conserved protein Function unknown 167648091 Nonpathogen - hypothetical protein Caul_4132 1 None None None 167647764 Common - helicase-like protein Caul_3803 30 COG4889 COG4889, Predicted helicase General function prediction only 167645822 Common - hypothetical protein Caul_1858 5 None None None 167646000 Common - protein of unknown function DUF736 Caul_2037 26 COG5489 COG5489, Uncharacterized conserved protein Function unknown 167644703 Common - alkylhydroperoxidase like protein, AhpD family Caul_0737 78 COG2128 COG2128, Uncharacterized conserved protein Function unknown 167647922 Nonpathogen - hypothetical protein Caul_3962 1 None None None 167645670 Common - hypothetical protein Caul_1706 9 None None None 167648642 Common - TonB-dependent receptor Caul_4687 8 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167648438 Common - NUDIX hydrolase Caul_4483 126 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 167648981 Common - Cobyrinic acid ac-diamide synthase Caul_5026 227 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 167644924 Common - protein of unknown function DUF485 Caul_0959 46 COG3162 COG3162, Predicted membrane protein Function unknown 167647765 Common - TIR protein Caul_3804 22 None None None 167647777 Common - putative transcriptional regulator Caul_3816 24 None None None 167644851 Nonpathogen - hypothetical protein Caul_0885 1 None None None 167645400 Nonpathogen - hypothetical protein Caul_1435 1 None None None 167647593 Common - addiction module antitoxin, RelB/DinJ family Caul_3631 35 COG3077 RelB, DNA-damage-inducible protein J DNA replication, recombination, and repair 167647271 Common - efflux transporter, RND family, MFP subunit Caul_3309 160 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 167648454 Common - SurF1 family protein Caul_4499 27 COG3346 COG3346, Uncharacterized conserved protein Function unknown 167646153 Common - S-adenosylmethionine--tRNA-ribosyltransferase-isomerase Caul_2190 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 167646251 Common - protein of unknown function DUF190 Caul_2289 49 COG1993 COG1993, Uncharacterized conserved protein Function unknown 167646185 Common - 2OG-Fe(II) oxygenase Caul_2222 14 COG3145 AlkB, Alkylated DNA repair protein DNA replication, recombination, and repair 167645707 Common - Alkaline phosphatase Caul_1743 60 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 167645620 Nonpathogen - hypothetical protein Caul_1656 1 None None None 167648838 Nonpathogen - hypothetical protein Caul_4883 1 None None None 167644892 Common - Glutathione S-transferase domain Caul_0926 81 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167647453 Nonpathogen - hypothetical protein Caul_3491 1 None None None 167645844 Common - hypothetical protein Caul_1880 67 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167645234 Common - transcriptional regulator, HxlR family Caul_1269 107 COG1733 COG1733, Predicted transcriptional regulators Transcription 167646085 Common - peptidase A24A domain protein Caul_2122 137 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 167645566 Common - drug resistance transporter, Bcr/CflA subfamily Caul_1602 176 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167646009 Common - protein of unknown function DUF1289 Caul_2046 37 COG3313 COG3313, Predicted Fe-S protein General function prediction only 167645077 Nonpathogen - hypothetical protein Caul_1112 1 None None None 167645595 Common - ribosomal protein S5 Caul_1631 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 167648945 Common - aconitate hydratase 1 Caul_4990 223 COG1048 AcnA, Aconitase A Energy production and conversion 167645239 Common - ErfK/YbiS/YcfS/YnhG family protein Caul_1274 71 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 167648787 Nonpathogen - zinc finger SWIM domain protein Caul_4832 1 COG4715 COG4715, Uncharacterized conserved protein Function unknown 167644028 Common - hypothetical protein Caul_0055 80 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 167644726 Common - protein of unknown function DUF1109 Caul_0760 12 COG4944 COG4944, Uncharacterized protein conserved in bacteria Function unknown 167645156 Common - ribosomal protein L20 Caul_1191 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 167648652 Common - Agmatine deiminase Caul_4697 87 COG2957 COG2957, Peptidylarginine deiminase and related enzymes Amino acid transport and metabolism 167647509 Common - phosphoglycolate phosphatase Caul_3547 204 COG0546 Gph, Predicted phosphatases General function prediction only 167645913 Common - secretion protein HlyD family protein Caul_1949 112 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 167646490 Common - Organic solvent tolerance protein Caul_2528 105 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 167644061 Nonpathogen - hypothetical protein Caul_0088 1 None None None 167647721 Common - major facilitator superfamily MFS_1 Caul_3759 21 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 167648511 Common - response regulator receiver and unknown domain protein Caul_4556 24 COG4565 CitB, Response regulator of citrate/malate metabolism Transcription / Signal transduction mechanisms 167646815 Common - glutamine synthetase, type I Caul_2853 231 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 167645486 Nonpathogen - hypothetical protein Caul_1521 1 None None None 167645998 Common - conjugation TrbI family protein Caul_2035 55 COG2948 VirB10, Type IV secretory pathway, VirB10 components Intracellular trafficking and secretion 167647121 Common - magnesium transporter Caul_3159 170 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 167648518 Common - protein of unknown function DUF6 transmembrane Caul_4563 44 COG2510 COG2510, Predicted membrane protein Function unknown 167645860 Common - 3-hydroxybutyryl-CoA dehydrogenase Caul_1896 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 167646491 Common - permease YjgP/YjgQ family protein Caul_2529 49 COG0795 COG0795, Predicted permeases General function prediction only 167648992 Common - protein-export protein SecB Caul_5037 107 COG1952 SecB, Preprotein translocase subunit SecB Intracellular trafficking and secretion 167644796 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Caul_0830 51 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 167645270 Nonpathogen - hypothetical protein Caul_1305 1 None None None 167646444 Common - 2'-5' RNA ligase Caul_2482 10 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 167647396 Common - transcriptional regulator, ArsR family Caul_3434 68 COG0640 ArsR, Predicted transcriptional regulators Transcription 167644258 Common - response regulator receiver protein Caul_0286 84 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 167646653 Nonpathogen - hypothetical protein Caul_2691 1 None None None 167645849 Common - aminoglycoside phosphotransferase Caul_1885 59 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 167643975 Common - 2OG-Fe(II) oxygenase Caul_0002 57 COG3145 AlkB, Alkylated DNA repair protein DNA replication, recombination, and repair 167648389 Common - ribosomal protein L1 Caul_4434 227 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 167646391 Common - hypothetical protein Caul_2429 15 None None None 167647693 Common - transposase IS3/IS911 family protein Caul_3731 44 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 167644118 Common - dienelactone hydrolase Caul_0145 38 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 167647010 Common - transcriptional regulator, MucR family Caul_3048 33 COG4957 COG4957, Predicted transcriptional regulator Transcription 167646139 Common - Cyclohexanone monooxygenase Caul_2176 67 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 167648843 Common - ribosomal protein S16 Caul_4888 213 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 167647073 Common - hypothetical protein Caul_3111 6 None None None 167644628 Nonpathogen - hypothetical protein Caul_0660 2 None None None 167648695 Common - ATP synthase F1, alpha subunit Caul_4740 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 167647081 Common - twin-arginine translocation protein, TatA/E family subunit Caul_3119 14 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 167644670 Common - Cytochrome b/b6 domain Caul_0702 149 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 167644268 Common - tryptophan halogenase Caul_0296 16 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 167644057 Nonpathogen - diacylglycerol kinase catalytic region Caul_0084 7 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 167646682 Common - short-chain dehydrogenase/reductase SDR Caul_2720 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167648509 Common - sulfate ABC transporter, periplasmic sulfate-binding protein Caul_4554 89 COG1613 Sbp, ABC-type sulfate transport system, periplasmic component Inorganic ion transport and metabolism 167646389 Common - anti-FecI sigma factor, FecR Caul_2427 45 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 167648130 Nonpathogen - hypothetical protein Caul_4171 1 None None None 167647254 Common - protein of unknown function DUF1446 Caul_3292 36 None None None 167648872 Nonpathogen - hypothetical protein Caul_4917 1 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 167645771 Nonpathogen - hypothetical protein Caul_1807 2 None None None 167647057 Common - hypothetical protein Caul_3095 17 COG4731 COG4731, Uncharacterized protein conserved in bacteria Function unknown 167647951 Common - ApbE family lipoprotein Caul_3991 138 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 167646180 Common - integrase family protein Caul_2217 113 COG0582 XerC, Integrase DNA replication, recombination, and repair 167644664 Common - glutamine amidotransferase class-I Caul_0696 175 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 167647167 Common - glutamyl-tRNA synthetase class Ic Caul_3205 240 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 167647550 Common - Histidinol dehydrogenase Caul_3588 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 167645814 Common - TonB-dependent receptor Caul_1850 33 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 167644094 Common - HemY domain protein Caul_0121 26 COG3898 COG3898, Uncharacterized membrane-bound protein Function unknown 167648734 Common - Fmu (Sun) domain protein Caul_4779 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 167644344 Common - glutamate--cysteine ligase Caul_0372 53 COG3572 GshA, Gamma-glutamylcysteine synthetase Coenzyme metabolism 167645793 Nonpathogen - hypothetical protein Caul_1829 1 None None None 167647044 Common - hypothetical protein Caul_3082 8 None None None 167644158 Nonpathogen - hypothetical protein Caul_0186 2 None None None 167646406 Nonpathogen - cytochrome oxidase maturation protein, cbb3-type Caul_2444 6 COG3197 FixS, Uncharacterized protein, possibly involved in nitrogen fixation Inorganic ion transport and metabolism 167645858 Common - acyl-CoA dehydrogenase domain protein Caul_1894 24 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167648467 Common - TonB-dependent receptor plug Caul_4512 8 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167646552 Nonpathogen - hypothetical protein Caul_2590 1 None None None 167647295 Common - hypothetical protein Caul_3333 10 None None None 167646582 Nonpathogen - hypothetical protein Caul_2620 5 None None None 167646170 Nonpathogen - hypothetical protein Caul_2207 1 None None None 167646026 Common - TonB-dependent receptor Caul_2063 30 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167644573 Nonpathogen - hypothetical protein Caul_0605 1 None None None 167645856 Common - acyl-CoA dehydrogenase domain protein Caul_1892 162 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167647288 Nonpathogen - UvrB/UvrC protein Caul_3326 1 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 167644637 Common - putative transposase of insertion sequence ISRm2011-2, orfA protein Caul_0669 20 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 167647351 Common - SMP-30/Gluconolaconase/LRE domain protein Caul_3389 72 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 167646101 Common - tryptophan halogenase Caul_2138 16 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 167647189 Common - Chorismate mutase Caul_3227 12 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 167646740 Common - Indole-3-glycerol-phosphate synthase Caul_2778 219 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 167644543 Common - Shikimate dehydrogenase substrate binding domain protein Caul_0575 47 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 167646179 Common - GMP synthase, large subunit Caul_2216 238 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 167644435 Nonpathogen - hypothetical protein Caul_0466 2 None None None 167644945 Common - peptide chain release factor 1 Caul_0980 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 167646258 Nonpathogen - hypothetical protein Caul_2296 1 None None None 167645284 Common - TonB-dependent receptor plug Caul_1319 24 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167646223 Common - DNA-cytosine methyltransferase Caul_2261 59 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 167645258 Common - peptidase M23B Caul_1293 5 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 167646186 Nonpathogen - hypothetical protein Caul_2223 1 None None None 167645243 Common - lipolytic protein G-D-S-L family Caul_1278 100 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 167648041 Common - TonB-dependent receptor Caul_4082 26 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167646437 Common - Rhodanese domain protein Caul_2475 122 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 167648247 Common - methyl-accepting chemotaxis sensory transducer Caul_4292 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 167644401 Common - TonB-dependent receptor Caul_0429 114 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167646772 Common - ABC transporter related Caul_2810 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 167645416 Nonpathogen - hypothetical protein Caul_1451 1 None None None 167644366 Common - DNA-cytosine methyltransferase Caul_0394 124 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 167645583 Common - ribosomal protein L22 Caul_1619 215 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 167647388 Common - acyl-CoA dehydrogenase domain protein Caul_3426 142 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167646579 Common - cobyric acid synthase CobQ Caul_2617 150 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 167648975 Common - Alcohol dehydrogenase zinc-binding domain protein Caul_5020 190 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 167648173 Common - hypothetical protein Caul_4214 35 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 167645507 Common - transcriptional regulator, IclR family Caul_1542 89 COG1414 IclR, Transcriptional regulator Transcription 167649030 Common - formamidopyrimidine-DNA glycosylase Caul_5075 180 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 167645184 Common - alpha/beta hydrolase fold Caul_1219 64 COG2267 PldB, Lysophospholipase Lipid metabolism 167645008 Common - Glutathione S-transferase domain Caul_1043 81 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167649010 Common - UBA/THIF-type NAD/FAD binding protein Caul_5055 208 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 167644044 Common - maleylacetoacetate isomerase Caul_0071 100 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167645123 Common - hypothetical protein Caul_1158 21 None None None 167648044 Nonpathogen - type IV pilus assembly PilZ Caul_4085 1 None None None 167645781 Nonpathogen - conserved hypothetical protein; putative signal peptide Caul_1817 11 None None None 167644125 Common - ybaK/ebsC protein Caul_0153 117 COG2606 EbsC, Uncharacterized conserved protein Function unknown 167646228 Common - superfamily I DNA or RNA helicase or helicase subunit-like protein Caul_2266 35 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 167648589 Common - polysaccharide biosynthesis protein CapD Caul_4634 191 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167648550 Nonpathogen - hypothetical protein Caul_4595 2 None None None 167645728 Common - protein of unknown function DUF336 Caul_1764 20 COG4702 COG4702, Uncharacterized conserved protein Function unknown 167644677 Common - hypothetical protein Caul_0709 7 None None None 167645357 Common - recA protein Caul_1392 214 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 167645391 Common - GntR domain protein Caul_1426 157 COG2186 FadR, Transcriptional regulators Transcription 167646827 Common - Antibiotic biosynthesis monooxygenase Caul_2865 9 COG1359 COG1359, Uncharacterized conserved protein Function unknown 167647497 Nonpathogen - hypothetical protein Caul_3535 1 None None None 167647850 Common - cytochrome C biogenesis protein Caul_3890 92 COG3088 CcmH, Uncharacterized protein involved in biosynthesis of c-type cytochromes Posttranslational modification, protein turnover, chaperones 167644468 Common - hypothetical protein Caul_0499 13 None None None 167646200 Nonpathogen - hypothetical protein Caul_2238 1 None None None 167649015 Common - beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA Caul_5060 82 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 167644981 Common - two component, sigma54 specific, transcriptional regulator, Fis family Caul_1016 172 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 167644885 Nonpathogen - hypothetical protein Caul_0919 3 None None None 167645459 Common - DNA-directed DNA polymerase Caul_1494 185 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 167648549 Nonpathogen - hypothetical protein Caul_4594 1 None None None 167647160 Common - Ubiquinone biosynthesis protein COQ7 Caul_3198 35 COG2941 CAT5, Ubiquinone biosynthesis protein COQ7 Coenzyme metabolism 167647525 Common - periplasmic glucan biosynthesis protein MdoG Caul_3563 50 COG3131 MdoG, Periplasmic glucans biosynthesis protein Inorganic ion transport and metabolism 167647984 Common - transcriptional regulator, TetR family Caul_4024 110 COG1309 AcrR, Transcriptional regulator Transcription 167647946 Common - peptidase M61 domain protein Caul_3986 54 COG3975 COG3975, Predicted protease with the C-terminal PDZ domain General function prediction only 167648808 Common - double-strand break repair helicase AddA Caul_4853 199 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 167648862 Common - Pyridoxal-5'-phosphate-dependent protein beta subunit Caul_4907 222 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 167644535 Common - hypothetical protein Caul_0567 6 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646014 Nonpathogen - hypothetical protein Caul_2051 1 None None None 167648165 Common - ATP-dependent DNA helicase RecQ Caul_4206 212 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 167645120 Common - putative transcriptional regulator Caul_1155 38 COG3636 COG3636, Predicted transcriptional regulator Transcription 167646366 Common - Beta-glucosidase Caul_2404 92 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 167647789 Common - Conjugal transfer protein TrbC Caul_3828 22 COG3838 VirB2, Type IV secretory pathway, VirB2 components (pilins) Intracellular trafficking and secretion 167647521 Common - putative transposase of insertion sequence ISRm2011-2, orfA protein Caul_3559 20 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646854 Common - GCN5-related N-acetyltransferase Caul_2892 36 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 167647530 Common - Uracil-DNA glycosylase superfamily Caul_3568 29 COG3663 Mug, G:T/U mismatch-specific DNA glycosylase DNA replication, recombination, and repair 167647244 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_3282 75 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167648223 Common - peptidase S8 and S53 subtilisin kexin sedolisin Caul_4267 27 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 167648540 Common - Leucyl aminopeptidase Caul_4585 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 167645972 Common - Antirestriction protein-like protein Caul_2009 45 COG4227 COG4227, Antirestriction protein DNA replication, recombination, and repair 167646427 Nonpathogen - hypothetical protein Caul_2465 1 None None None 167648595 Nonpathogen - Abortive infection protein Caul_4640 3 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 167648406 Common - hypothetical protein Caul_4451 5 None None None 167646900 Common - Stearoyl-CoA 9-desaturase Caul_2938 51 COG1398 OLE1, Fatty-acid desaturase Lipid metabolism 167644430 Nonpathogen - hypothetical protein Caul_0461 1 None None None 167648764 Nonpathogen - hypothetical protein Caul_4809 1 None None None 167645736 Common - Alpha,alpha-trehalose-phosphate synthase (UDP-forming) Caul_1772 97 COG0380 OtsA, Trehalose-6-phosphate synthase Carbohydrate transport and metabolism 167643999 Common - transcriptional regulator, XRE family Caul_0026 42 COG1396 HipB, Predicted transcriptional regulators Transcription 167647220 Common - hypothetical protein Caul_3258 16 None None None 167644582 Common - methyl-accepting chemotaxis sensory transducer Caul_0614 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 167644695 Common - aminotransferase class I and II Caul_0727 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 167645874 Common - short-chain dehydrogenase/reductase SDR Caul_1910 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167646265 Common - transcriptional regulator, AraC family Caul_2303 10 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 167645548 Nonpathogen - hypothetical protein Caul_1583 1 None None None 167646631 Nonpathogen - hypothetical protein Caul_2669 5 None None None 167647037 Common - GcrA cell cycle regulator Caul_3075 33 COG5352 COG5352, Uncharacterized protein conserved in bacteria Function unknown 167648349 Common - homoserine kinase Caul_4394 63 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 167645017 Common - transcriptional regulator, TetR family Caul_1052 129 COG1309 AcrR, Transcriptional regulator Transcription 167646995 Common - 3-oxoacyl-(acyl-carrier-protein) synthase III Caul_3033 219 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 167646372 Common - Alpha-N-arabinofuranosidase Caul_2410 32 COG3534 AbfA, Alpha-L-arabinofuranosidase Carbohydrate transport and metabolism 167646718 Common - Glutathione peroxidase Caul_2756 117 COG0386 BtuE, Glutathione peroxidase Posttranslational modification, protein turnover, chaperones 167645217 Common - hypothetical protein Caul_1252 16 COG3556 COG3556, Predicted membrane protein Function unknown 167648058 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_4099 85 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167647575 Common - Dihydroxy-acid dehydratase Caul_3613 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 167644412 Common - short-chain dehydrogenase/reductase SDR Caul_0440 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167645636 Common - TonB-dependent receptor Caul_1672 66 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647446 Common - portal protein Caul_3484 27 COG4695 COG4695, Phage-related protein Function unknown 167647935 Common - AMP-dependent synthetase and ligase Caul_3975 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167646907 Common - phosphopantetheine-binding Caul_2945 39 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167645803 Common - tryptophan halogenase Caul_1839 16 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 167644653 Nonpathogen - hypothetical protein Caul_0685 2 None None None 167644511 Nonpathogen - hypothetical protein Caul_0542 1 None None None 167644229 Common - deoxyhypusine synthase Caul_0257 63 COG1899 DYS1, Deoxyhypusine synthase Posttranslational modification, protein turnover, chaperones 167647087 Common - iron-sulfur cluster assembly accessory protein Caul_3125 164 COG0316 IscA, Uncharacterized conserved protein Function unknown 167644998 Common - Haloacid dehalogenase domain protein hydrolase Caul_1033 21 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 167646287 Common - efflux transporter, RND family, MFP subunit Caul_2325 162 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 167646838 Common - dethiobiotin synthase Caul_2876 151 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 167648415 Common - integral membrane sensor hybrid histidine kinase Caul_4460 211 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167646865 Nonpathogen - hypothetical protein Caul_2903 3 None None None 167644465 Common - MmgE/PrpD family protein Caul_0496 60 COG2079 PrpD, Uncharacterized protein involved in propionate catabolism General function prediction only 167647655 Common - integral membrane sensor hybrid histidine kinase Caul_3693 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167648262 Common - multi-sensor hybrid histidine kinase Caul_4307 212 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167646681 Common - short-chain dehydrogenase/reductase SDR Caul_2719 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167646806 Common - histone family protein DNA-binding protein Caul_2844 211 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 167646487 Common - dimethyladenosine transferase Caul_2525 244 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 167647080 Common - twin-arginine translocation protein, TatB subunit Caul_3118 26 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 167648318 Common - excinuclease ABC, C subunit-like protein Caul_4363 13 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 167645313 Common - glucose-methanol-choline oxidoreductase Caul_1348 91 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 167644991 Common - two component transcriptional regulator, winged helix family Caul_1026 213 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167645167 Common - protein of unknown function DUF885 Caul_1202 44 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 167648197 Common - potassium-transporting ATPase, C subunit Caul_4240 95 COG2156 KdpC, K+-transporting ATPase, c chain Inorganic ion transport and metabolism 167644546 Common - transcriptional regulator, IclR family Caul_0578 86 COG1414 IclR, Transcriptional regulator Transcription 167647927 Common - hypothetical protein Caul_3967 8 None None None 167645097 Common - Enoyl-CoA hydratase/isomerase Caul_1132 180 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 167646761 Common - 1-deoxy-D-xylulose 5-phosphate reductoisomerase Caul_2799 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 167647423 Common - hypothetical protein Caul_3461 31 COG4430 COG4430, Uncharacterized protein conserved in bacteria Function unknown 167644458 Common - transcriptional regulator, LysR family Caul_0489 150 COG0583 LysR, Transcriptional regulator Transcription 167647200 Common - transcriptional regulator, LysR family Caul_3238 135 COG0583 LysR, Transcriptional regulator Transcription 167645010 Common - transcriptional regulator, AsnC family Caul_1045 150 COG1522 Lrp, Transcriptional regulators Transcription 167645922 Common - short-chain dehydrogenase/reductase SDR Caul_1958 234 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167648103 Common - cobalt chelatase, pCobT subunit Caul_4144 44 COG4547 CobT, Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) Coenzyme metabolism 167648998 Common - phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Caul_5043 215 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 167647805 Common - DNA repair protein RadC Caul_3844 110 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 167647992 Common - transcriptional regulator, LysR family Caul_4032 134 COG0583 LysR, Transcriptional regulator Transcription 167645262 Common - histidine ammonia-lyase Caul_1297 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 167647110 Common - ATPase MipZ Caul_3148 43 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 167646965 Common - thiamine pyrophosphate protein domain protein TPP-binding Caul_3003 214 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 167647051 Common - transport system permease protein Caul_3089 110 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 167644140 Common - transcriptional regulator, XRE family Caul_0168 50 COG3655 COG3655, Predicted transcriptional regulator Transcription 167647433 Nonpathogen - hypothetical protein Caul_3471 2 None None None 167645832 Common - transcriptional regulator, AsnC family Caul_1868 129 COG1522 Lrp, Transcriptional regulators Transcription 167644224 Common - alpha/beta hydrolase fold Caul_0252 58 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167647064 Common - peptidase S9 prolyl oligopeptidase active site domain protein Caul_3102 117 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 167646617 Nonpathogen - hypothetical protein Caul_2655 1 None None None 167648892 Common - peptidylprolyl isomerase FKBP-type Caul_4937 139 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 167647546 Common - maf protein Caul_3584 190 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 167645788 Common - tail sheath protein Caul_1824 40 COG3497 COG3497, Phage tail sheath protein FI General function prediction only 167647003 Common - V-type H(+)-translocating pyrophosphatase Caul_3041 98 COG3808 OVP1, Inorganic pyrophosphatase Energy production and conversion 167645160 Common - peptidase S9 prolyl oligopeptidase active site domain protein Caul_1195 110 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 167647242 Common - TonB-dependent receptor Caul_3280 66 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167648152 Common - type II and III secretion system protein Caul_4193 128 COG4964 CpaC, Flp pilus assembly protein, secretin CpaC Intracellular trafficking and secretion 167647417 Common - phosphoribosylformylglycinamidine synthase II Caul_3455 233 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 167648840 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Caul_4885 22 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 167644719 Nonpathogen - TspO and MBR like protein Caul_0753 2 COG3476 COG3476, Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) Signal transduction mechanisms 167647676 Common - hypothetical protein Caul_3714 21 None None None 167647502 Common - AMP-dependent synthetase and ligase Caul_3540 212 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167644610 Common - ribosomal protein L34 Caul_0642 187 None None None 167645677 Common - lycopene cyclase Caul_1713 15 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 167648332 Common - ATP synthase F0, A subunit Caul_4377 167 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 167644744 Common - OsmC family protein Caul_0778 98 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 167647583 Nonpathogen - hypothetical protein Caul_3621 1 None None None 167646713 Common - lipoic acid synthetase Caul_2751 190 COG0320 LipA, Lipoate synthase Coenzyme metabolism 167648820 Common - Endonuclease/exonuclease/phosphatase Caul_4865 3 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 167645966 Common - transposase IS3/IS911 family protein Caul_2003 27 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 167648286 Common - signal transduction histidine kinase Caul_4331 133 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 167644068 Common - MCP methyltransferase, CheR-type Caul_0095 150 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 167648327 Common - DSBA oxidoreductase Caul_4372 62 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 167647962 Common - SMP-30/Gluconolaconase/LRE domain protein Caul_4002 89 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 167644760 Common - DNA-directed RNA polymerase, beta subunit Caul_0794 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 167645940 Common - histidine kinase Caul_1977 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167646057 Nonpathogen - hypothetical protein Caul_2094 3 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 167645165 Common - NAD-dependent epimerase/dehydratase Caul_1200 122 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167646929 Common - response regulator receiver protein Caul_2967 71 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 167644295 Common - hypothetical protein Caul_0323 3 None None None 167648561 Common - glucose-methanol-choline oxidoreductase Caul_4606 85 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 167645651 Common - NAD-dependent epimerase/dehydratase Caul_1687 95 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167646708 Common - DEAD/DEAH box helicase domain protein Caul_2746 239 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 167645435 Nonpathogen - hypothetical protein Caul_1470 2 COG3798 COG3798, Uncharacterized protein conserved in bacteria Function unknown 167647902 Common - sulfotransferase Caul_3942 115 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 167647690 Common - hypothetical protein Caul_3728 7 None None None 167645133 Nonpathogen - hypothetical protein Caul_1168 1 None None None 167646215 Common - Type IV secretory pathway VirD4 protein-like protein Caul_2253 23 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 167646199 Nonpathogen - transcriptional regulator, GntR family Caul_2237 1 COG1802 GntR, Transcriptional regulators Transcription 167647745 Common - TonB-dependent receptor plug Caul_3783 26 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 167644084 Common - acetate--CoA ligase Caul_0111 214 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 167648361 Common - hypothetical protein Caul_4406 12 None None None 167647178 Nonpathogen - MJ0042 family finger-like protein Caul_3216 11 None None None 167646485 Common - Guanylate kinase Caul_2523 214 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 167648370 Common - putative transcriptional regulator, Crp/Fnr family Caul_4415 40 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 167648530 Common - DNA polymerase III, subunits gamma and tau Caul_4575 248 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 167647093 Common - dihydroxy-acid dehydratase Caul_3131 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 167648939 Common - heme exporter protein CcmC Caul_4984 101 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 167644817 Common - short-chain dehydrogenase/reductase SDR Caul_0851 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167648443 Common - YceI family protein Caul_4488 113 COG2353 COG2353, Uncharacterized conserved protein Function unknown 167648614 Nonpathogen - hypothetical protein Caul_4659 1 None None None 167648725 Common - short-chain dehydrogenase/reductase SDR Caul_4770 226 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 167648855 Nonpathogen - hypothetical protein Caul_4900 1 None None None 167644548 Common - succinic semialdehyde dehydrogenase Caul_0580 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167645253 Common - Dihydroxy-acid dehydratase Caul_1288 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 167646320 Common - transcriptional regulator, histidine utilization repressor, GntR family Caul_2358 115 COG2188 PhnF, Transcriptional regulators Transcription 167646147 Common - DEAD/DEAH box helicase domain protein Caul_2184 237 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 167644353 Common - major facilitator superfamily MFS_1 Caul_0381 93 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 167648479 Common - glycosyl transferase family 2 Caul_4524 154 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 167648394 Nonpathogen - hypothetical protein Caul_4439 1 None None None 167647105 Common - glycerophosphoryl diester phosphodiesterase Caul_3143 140 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 167648033 Common - transcriptional regulator, AraC family Caul_4073 122 COG2169 Ada, Adenosine deaminase Nucleotide transport and metabolism 167644327 Common - hypothetical protein Caul_0355 20 None None None 167647458 Common - hypothetical protein Caul_3496 3 COG4672 gp18, Phage-related protein Function unknown 167648724 Common - flavodoxin/nitric oxide synthase Caul_4769 98 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 167647176 Common - methyl-accepting chemotaxis sensory transducer Caul_3214 147 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 167646676 Nonpathogen - NAD-dependent epimerase/dehydratase Caul_2714 9 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167645928 Nonpathogen - hypothetical protein Caul_1964 1 COG1554 ATH1, Trehalose and maltose hydrolases (possible phosphorylases) Carbohydrate transport and metabolism 167648529 Common - hypothetical protein Caul_4574 23 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 167644564 Common - integrase family protein Caul_0596 26 None None None 167644244 Common - amino acid permease-associated region Caul_0272 171 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 167648293 Common - TonB-dependent receptor Caul_4338 119 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 167647821 Common - molybdenum cofactor biosynthesis protein A Caul_3860 196 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 167644481 Common - short-chain dehydrogenase/reductase SDR Caul_0512 233 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 167645046 Common - exsB protein Caul_1081 162 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 167645496 Common - O-antigen polymerase Caul_1531 24 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 167647727 Nonpathogen - hypothetical protein Caul_3765 3 None None None 167645076 Common - TonB-dependent hemoglobin/transferrin/lactoferrin family receptor Caul_1111 131 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 167645083 Common - alpha/beta hydrolase fold Caul_1118 13 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 167646695 Common - Taurine dioxygenase Caul_2733 47 COG2175 TauD, Probable taurine catabolism dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 167645614 Common - Tetratricopeptide TPR_2 repeat protein Caul_1650 24 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 167648746 Nonpathogen - hypothetical protein Caul_4791 1 None None None 167645605 Nonpathogen - hypothetical protein Caul_1641 1 None None None 167645521 Common - protein of unknown function DUF1365 Caul_1556 62 COG3496 COG3496, Uncharacterized conserved protein Function unknown 167644381 Common - transcriptional regulator, TetR family Caul_0409 35 COG1309 AcrR, Transcriptional regulator Transcription 167645345 Common - cytochrome c class I Caul_1380 61 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 167647096 Common - Alcohol dehydrogenase zinc-binding domain protein Caul_3134 113 COG2130 COG2130, Putative NADP-dependent oxidoreductases General function prediction only 167648304 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Caul_4349 1 None None None 167644109 Common - UDP-glucose 4-epimerase Caul_0136 230 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 167648494 Common - protein of unknown function DUF374 Caul_4539 45 COG2121 COG2121, Uncharacterized protein conserved in bacteria Function unknown 167644446 Common - HipA domain protein Caul_0477 68 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 167648903 Common - Citrate (Si)-synthase Caul_4948 191 COG0372 GltA, Citrate synthase Energy production and conversion 167644467 Common - transcriptional regulator, GntR family Caul_0498 134 COG1802 GntR, Transcriptional regulators Transcription 167647814 Common - 3-oxoadipate enol-lactonase Caul_3853 112 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 167644911 Common - PilT protein domain protein Caul_0945 17 COG3742 COG3742, Uncharacterized protein conserved in bacteria Function unknown 167646789 Common - NADH-quinone oxidoreductase, chain G Caul_2827 191 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 167649026 Common - hypothetical protein Caul_5071 7 COG5529 COG5529, Pyocin large subunit General function prediction only 167648714 Common - integral membrane sensor hybrid histidine kinase Caul_4759 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167645656 Common - pseudouridine synthase Caul_1692 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 167648296 Common - Aldehyde Dehydrogenase_ Caul_4341 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167644528 Common - Amine dehydrogenase Caul_0560 12 None None None 167644872 Common - response regulator receiver protein Caul_0906 142 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 167645421 Common - helicase c2 Caul_1456 120 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 167644879 Common - NAD(P)H quinone oxidoreductase, PIG3 family Caul_0913 153 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 167647439 Nonpathogen - hypothetical protein Caul_3477 1 None None None 167647687 Common - putative signal-transduction protein with CBS domains Caul_3725 153 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 167645296 Common - toluene tolerance family protein Caul_1331 52 COG2854 Ttg2D, ABC-type transport system involved in resistance to organic solvents, auxiliary component Secondary metabolites biosynthesis, transport, and catabolism 167648899 Common - domain of unknown function DUF1730 Caul_4944 137 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 167648684 Common - hydrolase, alpha/beta hydrolase fold family Caul_4729 42 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167646274 Common - hypothetical protein Caul_2312 17 None None None 167647809 Common - 3-oxoacid CoA-transferase, B subunit Caul_3848 106 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 167648885 Common - DegT/DnrJ/EryC1/StrS aminotransferase Caul_4930 194 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 167647930 Common - transcriptional regulator, AraC family Caul_3970 47 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 167644578 Nonpathogen - sulfate transporter/antisigma-factor antagonist STAS Caul_0610 2 None None None 167644394 Nonpathogen - Xylose isomerase domain protein TIM barrel Caul_0422 2 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 167644478 Common - carboxyvinyl-carboxyphosphonate phosphorylmutase Caul_0509 135 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 167648470 Common - acetyl-CoA acetyltransferase Caul_4515 176 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167646417 Common - NUDIX hydrolase Caul_2455 20 COG4119 COG4119, Predicted NTP pyrophosphohydrolase DNA replication, recombination, and repair / General function prediction only 167646820 Common - transcriptional regulator, AraC family Caul_2858 38 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 167644051 Common - glutathione-dependent formaldehyde-activating GFA Caul_0078 58 COG3791 COG3791, Uncharacterized conserved protein Function unknown 167646913 Common - AMP-dependent synthetase and ligase Caul_2951 208 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167644713 Nonpathogen - hypothetical protein Caul_0747 3 None None None 167645474 Common - protein of unknown function DUF205 Caul_1509 170 COG0344 COG0344, Predicted membrane protein Function unknown 167645528 Nonpathogen - hypothetical protein Caul_1563 3 None None None 167648790 Common - ferredoxin Caul_4835 64 COG0633 Fdx, Ferredoxin Energy production and conversion 167646922 Common - ornithine carbamoyltransferase Caul_2960 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 167648664 Common - Ribonucleoside-diphosphate reductase Caul_4709 152 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 167648924 Nonpathogen - hypothetical protein Caul_4969 2 None None None 167647759 Common - helix-turn-helix domain protein Caul_3798 30 None None None 167644035 Common - aldo/keto reductase Caul_0062 14 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 167646638 Common - DSBA oxidoreductase Caul_2676 21 COG3917 NahD, 2-hydroxychromene-2-carboxylate isomerase Secondary metabolites biosynthesis, transport, and catabolism 167648930 Common - Phosphoribosylanthranilate isomerase Caul_4975 188 COG0135 TrpF, Phosphoribosylanthranilate isomerase Amino acid transport and metabolism 167648623 Common - sodium/hydrogen exchanger Caul_4668 180 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 167647660 Nonpathogen - hypothetical protein Caul_3698 1 None None None 167649001 Common - PfkB domain protein Caul_5046 150 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 167645069 Common - transposase IS3/IS911 family protein Caul_1104 44 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 167645447 Common - ParA family protein Caul_1482 76 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 167644303 Nonpathogen - hypothetical protein Caul_0331 2 None None None 167648289 Common - transcriptional regulator, LysR family Caul_4334 182 COG0583 LysR, Transcriptional regulator Transcription 167646424 Nonpathogen - cytochrome c class I Caul_2462 9 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 167643997 Common - CBS domain containing protein Caul_0024 218 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 167646379 Common - glycosyl transferase group 1 Caul_2417 160 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 167647318 Common - major intrinsic protein Caul_3356 123 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 167646564 Common - CinA domain protein Caul_2602 192 COG1546 CinA, Uncharacterized protein (competence- and mitomycin-induced) General function prediction only 167646818 Common - short-chain dehydrogenase/reductase SDR Caul_2856 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167646475 Nonpathogen - hypothetical protein Caul_2513 1 None None None 167647156 Nonpathogen - hypothetical protein Caul_3194 1 None None None 167648072 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Caul_4113 161 COG1146 COG1146, Ferredoxin Energy production and conversion 167646113 Common - valyl-tRNA synthetase Caul_2150 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 167645464 Common - ribosomal protein L33 Caul_1499 125 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 167645755 Common - major facilitator superfamily MFS_1 Caul_1791 54 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 167648829 Common - transcriptional regulator, PadR-like family Caul_4874 71 COG1695 COG1695, Predicted transcriptional regulators Transcription 167647135 Common - protein of unknown function DUF1428 Caul_3173 39 COG5507 COG5507, Uncharacterized conserved protein Function unknown 167645433 Nonpathogen - hypothetical protein Caul_1468 1 None None None 167644364 Nonpathogen - hypothetical protein Caul_0392 1 None None None 167645503 Common - polysaccharide biosynthesis protein Caul_1538 20 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 167644148 Common - hypothetical protein Caul_0176 41 COG2912 COG2912, Uncharacterized conserved protein Function unknown 167645519 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_1554 133 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167648425 Nonpathogen - hypothetical protein Caul_4470 2 None None None 167645485 Common - glutamyl-tRNA(Gln) amidotransferase, A subunit Caul_1520 219 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 167647577 Common - protein of unknown function DUF1238 Caul_3615 14 COG3802 GguC, Uncharacterized protein conserved in bacteria Function unknown 167647334 Common - hypothetical protein Caul_3372 4 None None None 167647019 Common - Porphobilinogen synthase Caul_3057 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 167644491 Common - transcriptional regulator, TetR family Caul_0522 36 COG1309 AcrR, Transcriptional regulator Transcription 167647046 Common - hypothetical protein Caul_3084 47 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 167644973 Nonpathogen - flagellar hook-length control protein Caul_1008 5 COG3144 FliK, Flagellar hook-length control protein Cell motility and secretion 167645361 Common - short-chain dehydrogenase/reductase SDR Caul_1396 235 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 167648571 Common - aldo/keto reductase Caul_4616 184 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 167644956 Common - ATP-dependent chaperone ClpB Caul_0991 215 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 167648489 Common - peptidase U62 modulator of DNA gyrase Caul_4534 157 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 167648067 Common - sodium:dicarboxylate symporter Caul_4108 163 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 167648203 Common - Hemolysin-type calcium-binding region Caul_4246 62 COG2931 COG2931, RTX toxins and related Ca2+-binding proteins Secondary metabolites biosynthesis, transport, and catabolism 167647507 Common - ribose 5-phosphate isomerase Caul_3545 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 167648568 Common - transcriptional regulator, LacI family Caul_4613 128 COG1609 PurR, Transcriptional regulators Transcription 167646780 Common - biotin--acetyl-CoA-carboxylase ligase Caul_2818 60 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 167644538 Common - beta-lactamase Caul_0570 129 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 167648357 Common - Rhodanese domain protein Caul_4402 36 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 167647479 Common - S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase Caul_3517 189 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 167645571 Common - translation elongation factor Tu Caul_1607 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 167647477 Common - S-formylglutathione hydrolase Caul_3515 92 COG0627 COG0627, Predicted esterase General function prediction only 167644789 Common - FAD dependent oxidoreductase Caul_0823 94 COG0579 COG0579, Predicted dehydrogenase General function prediction only 167646429 Common - hypothetical protein Caul_2467 16 COG5502 COG5502, Uncharacterized conserved protein Function unknown 167647750 Nonpathogen - hypothetical protein Caul_3788 1 None None None 167648952 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Caul_4997 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 167647878 Common - protein of unknown function DUF264 Caul_3918 25 COG5323 COG5323, Uncharacterized conserved protein Function unknown 167648066 Common - Polypeptide-transport-associated domain protein ShlB-type Caul_4107 64 COG2831 FhaC, Hemolysin activation/secretion protein Intracellular trafficking and secretion 167644422 Common - Propanoyl-CoA C-acyltransferase Caul_0450 118 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167646934 Common - protein of unknown function UPF0005 Caul_2972 70 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 167645907 Common - Integrase catalytic region Caul_1943 147 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 167647374 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Caul_3412 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 167648732 Common - protein of unknown function DUF1674 Caul_4777 10 COG5508 COG5508, Uncharacterized conserved small protein Function unknown 167644823 Common - aminotransferase class I and II Caul_0857 237 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 167645607 Common - Nucleotide diphosphatase Caul_1643 30 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 167647483 Common - AtsE protein Caul_3521 5 COG5622 COG5622, Protein required for attachment to host cells Cell motility and secretion 167646523 Common - NADH:ubiquinone oxidoreductase 17.2 kD subunit Caul_2561 38 COG3761 COG3761, NADH:ubiquinone oxidoreductase 17.2 kD subunit Energy production and conversion 167648077 Common - helicase domain protein Caul_4118 63 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 167645627 Common - hypothetical protein Caul_1663 18 COG4240 COG4240, Predicted kinase General function prediction only 167645896 Common - major facilitator superfamily MFS_1 Caul_1932 78 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 167646956 Nonpathogen - hypothetical protein Caul_2994 10 None None None 167645328 Common - PfkB domain protein Caul_1363 141 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 167648543 Common - protein of unknown function DUF343 Caul_4588 84 COG2835 COG2835, Uncharacterized conserved protein Function unknown 167646091 Common - ISSpo6, transposase orf A Caul_2128 10 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 167644377 Nonpathogen - hypothetical protein Caul_0405 1 None None None 167645026 Nonpathogen - hypothetical protein Caul_1061 1 None None None 167647532 Common - NUDIX hydrolase Caul_3570 28 None None None 167645996 Common - Conjugal transfer protein Caul_2033 33 COG3701 TrbF, Type IV secretory pathway, TrbF components Intracellular trafficking and secretion 167647581 Common - acetyl-CoA acetyltransferase Caul_3619 173 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167648019 Common - hypothetical protein Caul_4059 14 None None None 167647870 Common - phage major tail protein, TP901-1 family Caul_3910 18 COG5437 COG5437, Predicted secreted protein Function unknown 167646593 Common - copper-resistance protein, CopA family Caul_2631 122 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 167645795 Common - lipolytic protein G-D-S-L family Caul_1831 16 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 167648777 Common - bis(5'nucleosyl)-tetraphosphatase, ApaH Caul_4822 58 COG0639 ApaH, Diadenosine tetraphosphatase and related serine/threonine protein phosphatases Signal transduction mechanisms 167648482 Common - nitrogen-fixing NifU domain protein Caul_4527 52 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 167644903 Common - mutator MutT protein Caul_0937 168 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 167646721 Common - Transketolase central region Caul_2759 186 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 167648431 Common - PilT protein domain protein Caul_4476 17 COG3742 COG3742, Uncharacterized protein conserved in bacteria Function unknown 167644595 Common - L-carnitine dehydratase/bile acid-inducible protein F Caul_0627 115 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 167645665 Common - penicillin-binding protein, 1A family Caul_1701 201 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 167648490 Common - Inositol-phosphate phosphatase Caul_4535 198 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 167644557 Common - beta-lactamase Caul_0589 120 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 167645978 Common - conjugal transfer protein TraF Caul_2015 32 COG4959 TraF, Type IV secretory pathway, protease TraF Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 167646541 Common - peptidase M23B Caul_2579 190 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 167647915 Common - Aldehyde Dehydrogenase_ Caul_3955 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167645191 Common - exodeoxyribonuclease VII, large subunit Caul_1226 204 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 167646853 Common - acylneuraminate cytidylyltransferase Caul_2891 81 COG1861 SpsF, Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog Cell envelope biogenesis, outer membrane 167648982 Common - parB-like partition protein Caul_5027 185 COG1475 Spo0J, Predicted transcriptional regulators Transcription 167647123 Common - lipoate-protein ligase B Caul_3161 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 167647975 Common - transcriptional regulator, TetR family Caul_4015 51 COG1309 AcrR, Transcriptional regulator Transcription 167647308 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Caul_3346 191 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 167648321 Common - Ribonuclease H Caul_4366 217 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 167644167 Nonpathogen - hypothetical protein Caul_0195 1 None None None 167647236 Common - Integrase catalytic region Caul_3274 146 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 167644337 Nonpathogen - hypothetical protein Caul_0365 3 None None None 167645712 Common - major facilitator superfamily MFS_1 Caul_1748 66 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167646110 Common - hypothetical protein Caul_2147 59 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 167646604 Common - Di-haem cytochrome c peroxidase Caul_2642 93 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 167648913 Common - RNA polymerase, sigma 54 subunit, RpoN Caul_4958 145 COG1508 RpoN, DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog Transcription 167647971 Common - short-chain dehydrogenase/reductase SDR Caul_4011 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167646706 Common - hypothetical protein Caul_2744 15 COG5350 COG5350, Predicted protein tyrosine phosphatase General function prediction only 167646757 Common - UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase Caul_2795 145 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 167645882 Common - hypothetical protein Caul_1918 10 COG1141 Fer, Ferredoxin Energy production and conversion 167648708 Nonpathogen - hypothetical protein Caul_4753 1 None None None 167646504 Common - Membrane dipeptidase Caul_2542 101 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 167646124 Common - Radical SAM domain protein Caul_2161 106 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 167648255 Common - short-chain dehydrogenase/reductase SDR Caul_4300 146 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 167647703 Common - PhoH family protein Caul_3741 199 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 167645575 Common - hypothetical protein Caul_1611 41 COG4386 COG4386, Mu-like prophage tail sheath protein gpL General function prediction only 167646294 Nonpathogen - hypothetical protein Caul_2332 1 None None None 167644498 Common - NmrA family protein Caul_0529 76 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167646731 Common - Triose-phosphate isomerase Caul_2769 224 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 167644330 Nonpathogen - hypothetical protein Caul_0358 1 None None None 167647715 Common - NUDIX hydrolase Caul_3753 115 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 167644314 Common - thioesterase superfamily protein Caul_0342 45 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 167644819 Common - hypothetical protein Caul_0853 5 COG3692 COG3692, Uncharacterized protein conserved in bacteria Function unknown 167645304 Common - hypothetical protein Caul_1339 8 None None None 167645703 Common - Arylamine N-acetyltransferase Caul_1739 45 COG2162 NhoA, Arylamine N-acetyltransferase Secondary metabolites biosynthesis, transport, and catabolism 167644127 Nonpathogen - hypothetical protein Caul_0155 2 None None None 167647343 Common - ketol-acid reductoisomerase Caul_3381 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 167644202 Common - succinyl-CoA synthetase, alpha subunit Caul_0230 206 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 167644409 Common - major facilitator superfamily MFS_1 Caul_0437 76 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167645308 Common - Oligopeptidase B Caul_1343 108 COG1770 PtrB, Protease II Amino acid transport and metabolism 167644596 Common - Aldose 1-epimerase Caul_0628 52 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 167643981 Common - DNA mismatch repair protein MutS Caul_0008 198 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 167644183 Common - Catalase Caul_0211 127 COG0753 KatE, Catalase Inorganic ion transport and metabolism 167647281 Common - histone deacetylase superfamily Caul_3319 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 167646342 Common - ATPase, P-type (transporting), HAD superfamily, subfamily IC Caul_2380 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 167648060 Common - transcriptional regulator, TetR family Caul_4101 20 COG1309 AcrR, Transcriptional regulator Transcription 167646313 Common - copper resistance B precursor Caul_2351 43 COG3667 PcoB, Uncharacterized protein involved in copper resistance Inorganic ion transport and metabolism 167645743 Common - Amylo-alpha-16-glucosidase Caul_1779 56 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 167646646 Common - twin-arginine translocation pathway signal Caul_2684 32 COG2930 COG2930, Uncharacterized conserved protein Function unknown 167646454 Nonpathogen - hypothetical protein Caul_2492 1 None None None 167647065 Common - hypothetical protein Caul_3103 2 None None None 167644602 Common - cytochrome bd ubiquinol oxidase subunit I Caul_0634 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 167646161 Common - protein of unknown function DUF404 Caul_2198 89 COG2308 COG2308, Uncharacterized conserved protein Function unknown 167647182 Common - phospholipid/glycerol acyltransferase Caul_3220 165 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 167646403 Common - cytochrome c oxidase accessory protein CcoG Caul_2441 88 COG0348 NapH, Polyferredoxin Energy production and conversion 167648182 Common - high-affinity nickel-transporter Caul_4225 27 COG2215 COG2215, ABC-type uncharacterized transport system, permease component General function prediction only 167644916 Nonpathogen - hypothetical protein Caul_0951 1 None None None 167645824 Common - anti-FecI sigma factor, FecR Caul_1860 46 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 167647146 Common - uracil phosphoribosyltransferase Caul_3184 164 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 167646474 Common - ribosomal protein S6 Caul_2512 201 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 167644217 Common - Mg2 transporter protein CorA family protein Caul_0245 163 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 167646987 Common - ribosomal protein S9 Caul_3025 249 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 167645941 Common - hypothetical protein Caul_1978 2 None None None 167645183 Nonpathogen - Sterol-binding domain protein Caul_1218 5 COG3255 COG3255, Putative sterol carrier protein Lipid metabolism 167647399 Common - Glutathione S-transferase domain Caul_3437 81 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167645512 Common - Pyridoxal 4-dehydrogenase Caul_1547 63 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 167645681 Common - methyltransferase Caul_1717 26 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 167645798 Common - GntR domain protein Caul_1834 145 COG2186 FadR, Transcriptional regulators Transcription 167647212 Common - major facilitator superfamily MFS_1 Caul_3250 190 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167645774 Nonpathogen - hypothetical protein Caul_1810 4 None None None 167644286 Nonpathogen - amidohydrolase 2 Caul_0314 6 None None None 167644951 Common - putative addiction module antidote protein, CopG/Arc/MetJ family Caul_0986 10 COG3609 COG3609, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain Transcription 167646280 Common - transcriptional regulator, MerR family Caul_2318 142 COG0789 SoxR, Predicted transcriptional regulators Transcription 167645381 Common - (2Fe-2S)-binding domain protein Caul_1416 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 167648814 Common - Intracellular septation protein A Caul_4859 73 COG2917 COG2917, Intracellular septation protein A Cell division and chromosome partitioning 167644425 Common - transposase IS3/IS911 family protein Caul_0453 44 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 167644647 Nonpathogen - hypothetical protein Caul_0679 1 None None None 167646887 Common - Rhodanese domain protein Caul_2925 145 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 167646629 Common - Alkanesulfonate monooxygenase Caul_2667 85 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 167646207 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_2245 65 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167644755 Common - ribosomal protein L10 Caul_0789 213 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 167645388 Common - Transglycosylase-associated protein Caul_1423 4 COG2261 COG2261, Predicted membrane protein Function unknown 167647626 Nonpathogen - hypothetical protein Caul_3664 1 None None None 167645783 Common - AAA ATPase central domain protein Caul_1819 247 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 167648028 Nonpathogen - hypothetical protein Caul_4068 1 COG4982 COG4982, 3-oxoacyl- acyl-carrier protein 167645225 Common - binding-protein-dependent transport systems inner membrane component Caul_1260 56 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 167647510 Common - GAF sensor hybrid histidine kinase Caul_3548 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167647847 Nonpathogen - hypothetical protein Caul_3887 1 None None None 167647567 Common - aldehyde oxidase and xanthine dehydrogenase molybdopterin binding Caul_3605 109 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 167648187 Common - heat shock protein Hsp20 Caul_4230 158 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 167648632 Nonpathogen - hypothetical protein Caul_4677 3 None None None 167648303 Common - hypothetical protein Caul_4348 20 COG3671 COG3671, Predicted membrane protein Function unknown 167645200 Common - Rhodanese domain protein Caul_1235 107 COG1054 COG1054, Predicted sulfurtransferase General function prediction only 167644810 Common - hypothetical protein Caul_0844 7 None None None 167646982 Common - putative HlyD family secretion protein Caul_3020 113 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 167646905 Common - aminotransferase class I and II Caul_2943 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 167646050 Nonpathogen - hypothetical protein Caul_2087 1 None None None 167648358 Common - transcriptional regulator, AraC family Caul_4403 92 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 167644133 Nonpathogen - hypothetical protein Caul_0161 1 None None None 167647539 Common - FAD dependent oxidoreductase Caul_3577 36 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 167647987 Common - RND efflux system, outer membrane lipoprotein, NodT family Caul_4027 127 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 167644884 Common - lipid A ABC exporter family, fused ATPase and inner membrane subunits Caul_0918 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 167645409 Common - transcriptional regulator, Crp/Fnr family Caul_1444 29 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 167648242 Nonpathogen - hypothetical protein Caul_4286 1 None None None 167648670 Common - alpha-1,2-mannosidase Caul_4715 26 COG3537 COG3537, Putative alpha-1,2-mannosidase Carbohydrate transport and metabolism 167645936 Common - Phosphoglycerate mutase Caul_1972 15 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 167647881 Common - penicillin-binding protein, 1A family Caul_3921 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 167648265 Common - protein of unknown function DUF820 Caul_4310 22 COG4636 Uma2, Uncharacterized protein conserved in cyanobacteria Function unknown 167646046 Common - ABC-2 type transporter Caul_2083 33 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 167644120 Common - hypothetical protein Caul_0147 12 None None None 167644277 Nonpathogen - hypothetical protein Caul_0305 2 COG0135 TrpF, Phosphoribosylanthranilate isomerase Amino acid transport and metabolism 167648878 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Caul_4923 160 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 167645914 Common - ABC transporter related Caul_1950 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 167645158 Common - peptidase S9 prolyl oligopeptidase active site domain protein Caul_1193 107 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 167648190 Common - Erythromycin esterase Caul_4233 79 COG2312 COG2312, Erythromycin esterase homolog General function prediction only 167648799 Common - transcriptional regulator, LysR family Caul_4844 156 COG0583 LysR, Transcriptional regulator Transcription 167647695 Common - peptidase M56 BlaR1 Caul_3733 10 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 167644728 Common - Lysine--tRNA ligase Caul_0762 200 COG2269 COG2269, Truncated, possibly inactive, lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 167646267 Nonpathogen - putative integral membrane protein Caul_2305 4 None None None 167644842 Common - hypothetical protein Caul_0876 38 COG3750 COG3750, Uncharacterized protein conserved in bacteria Function unknown 167646449 Common - arsenate reductase and related Caul_2487 108 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 167647420 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Caul_3458 30 COG4529 COG4529, Uncharacterized protein conserved in bacteria Function unknown 167644041 Common - penicillin-binding protein 1C Caul_0068 200 COG4953 PbpC, Membrane carboxypeptidase/penicillin-binding protein PbpC Cell envelope biogenesis, outer membrane 167648427 Nonpathogen - hypothetical protein Caul_4472 1 None None None 167643983 Nonpathogen - hypothetical protein Caul_0010 1 None None None 167645718 Common - Altronate dehydratase Caul_1754 73 COG2721 UxaA, Altronate dehydratase Carbohydrate transport and metabolism 167645597 Common - ribosomal protein L15 Caul_1633 216 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 167646137 Common - glycyl-tRNA synthetase, alpha subunit Caul_2174 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 167645481 Common - dihydroorotase, multifunctional complex type Caul_1516 209 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 167644256 Common - CheD Caul_0284 87 COG1871 CheD, Chemotaxis protein; stimulates methylation of MCP proteins Cell motility and secretion / Signal transduction mechanisms 167647621 Common - cell division protein FtsQ Caul_3659 37 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 167646144 Common - Excinuclease ABC C subunit domain protein Caul_2181 32 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 167648073 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Caul_4114 187 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 167648686 Common - transposase and inactivated derivatives-like protein Caul_4731 46 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 167644342 Common - protein of unknown function DUF558 Caul_0370 198 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 167646493 Common - Leucyl aminopeptidase Caul_2531 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 167648870 Common - transketolase Caul_4915 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 167648666 Nonpathogen - hypothetical protein Caul_4711 1 None None None 167644672 Nonpathogen - hypothetical protein Caul_0704 1 None None None 167648495 Common - cation diffusion facilitator family transporter Caul_4540 179 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 167648507 Common - Autotransporter beta- domain protein Caul_4552 17 COG3889 COG3889, Predicted solute binding protein General function prediction only 167645488 Common - glutamyl-tRNA(Gln) amidotransferase, B subunit Caul_1523 211 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 167647083 Common - chromosome segregation and condensation protein ScpA Caul_3121 89 COG1354 COG1354, Uncharacterized conserved protein Function unknown 167647377 Common - TonB-dependent receptor Caul_3415 94 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167648816 Common - protein of unknown function UPF0126 Caul_4861 130 COG2860 COG2860, Predicted membrane protein Function unknown 167648742 Common - NAD-glutamate dehydrogenase Caul_4787 77 COG2902 COG2902, NAD-specific glutamate dehydrogenase Amino acid transport and metabolism 167646856 Common - ATPase associated with various cellular activities AAA_5 Caul_2894 93 COG0714 COG0714, MoxR-like ATPases General function prediction only 167646442 Common - histidine kinase Caul_2480 103 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 167644096 Common - TonB-dependent receptor plug Caul_0123 116 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 167644062 Common - putative RNA polymerase, sigma 70 family subunit Caul_0089 118 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 167647661 Common - Glutathione S-transferase domain Caul_3699 69 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167644208 Common - methyl-accepting chemotaxis sensory transducer Caul_0236 145 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 167648697 Nonpathogen - hypothetical protein Caul_4742 1 None None None 167647370 Common - Beta-lactamase Caul_3408 55 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 167647735 Nonpathogen - hypothetical protein Caul_3773 3 None None None 167648681 Common - protein of unknown function DUF610 YibQ Caul_4726 45 COG2861 COG2861, Uncharacterized protein conserved in bacteria Function unknown 167646289 Nonpathogen - hypothetical protein Caul_2327 1 None None None 167648328 Common - chromosome segregation protein SMC Caul_4373 175 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 167647055 Common - hypothetical protein Caul_3093 27 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 167644666 Nonpathogen - Abortive infection protein Caul_0698 3 None None None 167646580 Common - protein of unknown function DUF339 Caul_2618 39 COG2938 COG2938, Uncharacterized conserved protein Function unknown 167648460 Common - cytochrome c oxidase, subunit I Caul_4505 167 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 167648392 Common - transcriptional regulator, TetR family Caul_4437 61 COG1309 AcrR, Transcriptional regulator Transcription 167646615 Common - sodium:dicarboxylate symporter Caul_2653 150 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 167644541 Common - short-chain dehydrogenase/reductase SDR Caul_0573 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167648456 Common - cytochrome c oxidase subunit III Caul_4501 159 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 167647162 Nonpathogen - hypothetical protein Caul_3200 1 COG5652 COG5652, Predicted integral membrane protein Function unknown 167644938 Common - transcriptional regulator, TetR family Caul_0973 65 COG1309 AcrR, Transcriptional regulator Transcription 167645063 Common - Tail Collar domain protein Caul_1098 35 COG4675 MdpB, Microcystin-dependent protein Function unknown 167645816 Common - transcription factor jumonji jmjC domain protein Caul_1852 19 None None None 167647017 Common - acyl-CoA dehydrogenase domain protein Caul_3055 164 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167645493 Common - polysaccharide export protein Caul_1528 108 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 167648330 Nonpathogen - hypothetical protein Caul_4375 1 None None None 167644403 Common - Xylose isomerase domain protein TIM barrel Caul_0431 73 COG3622 Hfi, Hydroxypyruvate isomerase Carbohydrate transport and metabolism 167648469 Common - acetoacetyl-CoA reductase Caul_4514 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167644620 Common - RelE-like cytotoxic translational repressor of toxin-antitoxin stability system Caul_0652 14 COG4737 COG4737, Uncharacterized protein conserved in bacteria Function unknown 167645551 Common - integral membrane sensor signal transduction histidine kinase Caul_1586 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167644502 Common - alpha/beta hydrolase fold Caul_0533 100 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167645879 Common - Alcohol dehydrogenase zinc-binding domain protein Caul_1915 112 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 167647963 Common - Dihydroxy-acid dehydratase Caul_4003 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 167645197 Common - ornithine carbamoyltransferase Caul_1232 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 167648112 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Caul_4153 54 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 167648517 Common - succinyl-diaminopimelate desuccinylase Caul_4562 208 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 167646467 Nonpathogen - hypothetical protein Caul_2505 5 None None None 167648869 Common - NAD+ synthetase Caul_4914 188 COG0171 NadE, NAD synthase Coenzyme metabolism 167646075 Common - sulfotransferase Caul_2112 47 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 167648842 Common - signal recognition particle protein Caul_4887 246 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 167648735 Common - Ribulose-phosphate 3-epimerase Caul_4780 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 167646673 Common - TonB-dependent receptor Caul_2711 115 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167648647 Nonpathogen - hypothetical protein Caul_4692 1 COG2030 MaoC, Acyl dehydratase Lipid metabolism 167647240 Common - tryptophan halogenase Caul_3278 16 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 167646658 Common - hypothetical protein Caul_2696 77 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 167647119 Common - acyl-CoA dehydrogenase domain protein Caul_3157 159 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167647779 Common - Cobyrinic acid ac-diamide synthase Caul_3818 164 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 167646243 Nonpathogen - hypothetical protein Caul_2281 2 None None None 167645273 Common - protein of unknown function DUF1486 Caul_1308 10 None None None 167645473 Common - DNA protecting protein DprA Caul_1508 209 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 167644853 Common - thioesterase superfamily protein Caul_0887 23 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 167646033 Common - carbohydrate kinase, thermoresistant glucokinase family Caul_2070 80 COG3265 GntK, Gluconate kinase Carbohydrate transport and metabolism 167644235 Common - phosphate ABC transporter, periplasmic phosphate-binding protein PstS, putative Caul_0263 130 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 167645012 Common - Electron transfer flavoprotein alpha/beta-subunit Caul_1047 153 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 167648523 Common - methionyl-tRNA formyltransferase Caul_4568 215 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 167647515 Common - tRNA/rRNA methyltransferase (SpoU) Caul_3553 205 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 167646559 Common - phospholipid/glycerol acyltransferase Caul_2597 93 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 167645337 Common - Protein of unknown function DUF1778 Caul_1372 21 COG4453 COG4453, Uncharacterized protein conserved in bacteria Function unknown 167646715 Common - AMP-dependent synthetase and ligase Caul_2753 218 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167647269 Common - acriflavin resistance protein Caul_3307 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 167645643 Common - permease YjgP/YjgQ family protein Caul_1679 29 COG0795 COG0795, Predicted permeases General function prediction only 167648137 Nonpathogen - hypothetical protein Caul_4178 1 None None None 167646951 Common - phosphonoacetaldehyde hydrolase Caul_2989 46 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 167648311 Common - AMP-dependent synthetase and ligase Caul_4356 180 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167648810 Nonpathogen - hypothetical protein Caul_4855 1 None None None 167647451 Nonpathogen - hypothetical protein Caul_3489 1 None None None 167645564 Common - transposase IS116/IS110/IS902 family protein Caul_1600 63 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 167645953 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_1990 58 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167647796 Common - P-type conjugative transfer protein TrbG Caul_3835 50 COG3504 VirB9, Type IV secretory pathway, VirB9 components Intracellular trafficking and secretion 167646452 Nonpathogen - hypothetical protein Caul_2490 2 None None None 167647180 Common - protein of unknown function DUF214 Caul_3218 32 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 167645237 Common - Carotenoid oxygenase Caul_1272 36 COG3670 COG3670, Lignostilbene-alpha,beta-dioxygenase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 167646253 Nonpathogen - Activator of Hsp90 ATPase 1 family protein Caul_2291 3 COG3832 COG3832, Uncharacterized conserved protein Function unknown 167645280 Common - AMP-dependent synthetase and ligase Caul_1315 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167647495 Common - protein of unknown function DUF1080 Caul_3533 6 None None None 167647637 Common - S-adenosyl-methyltransferase MraW Caul_3675 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 167648577 Common - pyridoxine kinase Caul_4622 42 COG2240 PdxK, Pyridoxal/pyridoxine/pyridoxamine kinase Coenzyme metabolism 167644931 Nonpathogen - hypothetical protein Caul_0966 9 None None None 167644706 Common - Resolvase domain Caul_0740 67 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 167646012 Common - acyl-CoA dehydrogenase domain protein Caul_2049 137 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167645862 Common - short-chain dehydrogenase/reductase SDR Caul_1898 227 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 167644238 Common - glycosyl transferase group 1 Caul_0266 184 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 167644137 Common - GrpE protein Caul_0165 228 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 167648649 Common - TonB-dependent receptor Caul_4694 113 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647187 Common - plasmid maintenance system antidote protein, XRE family Caul_3225 84 COG3093 VapI, Plasmid maintenance system antidote protein General function prediction only 167644322 Nonpathogen - hypothetical protein Caul_0350 3 None None None 167645709 Common - beta-lactamase Caul_1745 123 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 167645622 Common - pseudouridine synthase, RluA family Caul_1658 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 167647890 Common - efflux transporter, RND family, MFP subunit Caul_3930 169 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 167646633 Common - alpha/beta hydrolase fold Caul_2671 130 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167647260 Common - PAS/PAC sensor hybrid histidine kinase Caul_3298 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167646349 Common - transcriptional regulator, AraC family Caul_2387 112 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 167646282 Common - hypothetical protein Caul_2320 36 COG5569 COG5569, Uncharacterized conserved protein Function unknown 167645581 Common - ribosomal protein L2 Caul_1617 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 167644022 Common - (2Fe-2S)-binding domain protein Caul_0049 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 167645272 Common - OsmC family protein Caul_1307 90 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 167644894 Nonpathogen - hypothetical protein Caul_0928 1 None None None 167649029 Common - ubiquinone/menaquinone biosynthesis methyltransferase Caul_5074 202 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 167648864 Common - transaldolase Caul_4909 162 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 167646879 Common - protein of unknown function DUF35 Caul_2917 41 COG3425 PksG, 3-hydroxy-3-methylglutaryl CoA synthase Lipid metabolism 167647347 Common - Thymidylate synthase Caul_3385 144 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 167645846 Common - transcriptional regulator, IclR family Caul_1882 53 COG1414 IclR, Transcriptional regulator Transcription 167647932 Common - glycoside hydrolase family 3 domain protein Caul_3972 123 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 167648762 Common - polysaccharide biosynthesis protein Caul_4807 14 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 167645129 Common - hypothetical protein Caul_1164 13 None None None 167644410 Common - Aldehyde Dehydrogenase_ Caul_0438 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167646863 Common - fatty acid hydroxylase Caul_2901 72 COG3000 ERG3, Sterol desaturase Lipid metabolism 167646902 Nonpathogen - phosphopantetheine-binding Caul_2940 1 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167645805 Common - tryptophan halogenase Caul_1841 16 None None None 167644336 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Caul_0364 30 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 167646508 Common - ribonuclease D Caul_2546 124 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 167644004 Common - NusA antitermination factor Caul_0031 216 COG0195 NusA, Transcription elongation factor Transcription 167645402 Nonpathogen - Tetratricopeptide TPR_4 Caul_1437 10 None None None 167647657 Nonpathogen - hypothetical protein Caul_3695 1 None None None 167646543 Common - tyrosyl-tRNA synthetase Caul_2581 216 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 167645096 Common - major facilitator superfamily MFS_1 Caul_1131 148 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 167644111 Nonpathogen - hypothetical protein Caul_0138 5 None None None 167645286 Common - hypothetical protein Caul_1321 29 None None None 167646804 Common - glycosyltransferase, MGT family Caul_2842 61 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 167644194 Common - methyl-accepting chemotaxis sensory transducer Caul_0222 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 167648940 Nonpathogen - hypothetical protein Caul_4985 1 None None None 167648248 Common - transcription elongation factor GreA Caul_4293 204 COG0782 GreA, Transcription elongation factor Transcription 167648890 Common - threonine dehydratase Caul_4935 203 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 167644222 Nonpathogen - 17 kDa surface antigen Caul_0250 2 None None None 167646059 Nonpathogen - hypothetical protein Caul_2096 1 None None None 167645616 Nonpathogen - hypothetical protein Caul_1652 1 None None None 167647098 Common - ATP-dependent Clp protease, ATP-binding subunit clpA Caul_3136 233 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 167647021 Nonpathogen - hypothetical protein Caul_3059 1 None None None 167648475 Nonpathogen - hypothetical protein Caul_4520 12 None None None 167648817 Common - helix-turn-helix domain protein Caul_4862 33 COG5499 COG5499, Predicted transcription regulator containing HTH domain Transcription 167647897 Common - GCN5-related N-acetyltransferase Caul_3937 78 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 167646768 Common - hypothetical protein Caul_2806 4 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 167647887 Nonpathogen - hypothetical protein Caul_3927 1 None None None 167645514 Common - amidohydrolase 2 Caul_1549 45 COG3618 COG3618, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 167647566 Common - GreA/GreB family elongation factor Caul_3604 63 COG0782 GreA, Transcription elongation factor Transcription 167646121 Common - Methyltransferase type 11 Caul_2158 37 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 167644715 Nonpathogen - hypothetical protein Caul_0749 1 None None None 167647432 Nonpathogen - hypothetical protein Caul_3470 1 None None None 167644887 Common - major facilitator superfamily MFS_1 Caul_0921 176 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 167647500 Common - peptidase M23B Caul_3538 8 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 167647880 Common - protein of unknown function UPF0153 Caul_3920 74 COG2983 COG2983, Uncharacterized conserved protein Function unknown 167644215 Common - acyltransferase 3 Caul_0243 43 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 167648192 Nonpathogen - hypothetical protein Caul_4235 1 None None None 167644227 Common - putative ferric uptake regulator, Fur family Caul_0255 80 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 167644612 Common - Alcohol dehydrogenase zinc-binding domain protein Caul_0644 178 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 167647256 Common - transcriptional regulator, LysR family Caul_3294 192 COG0583 LysR, Transcriptional regulator Transcription 167648805 Common - aminoglycoside phosphotransferase Caul_4850 76 COG3178 COG3178, Predicted phosphotransferase related to Ser/Thr protein kinases General function prediction only 167644042 Common - flagellin domain protein Caul_0069 114 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 167647366 Common - D-alanine--D-alanine ligase Caul_3404 206 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 167646975 Common - Inositol phosphatase/fructose-16-bisphosphatase Caul_3013 108 COG0158 Fbp, Fructose-1,6-bisphosphatase Carbohydrate transport and metabolism 167648154 Common - peptidase A24A prepilin type IV Caul_4195 21 COG4960 CpaA, Flp pilus assembly protein, protease CpaA Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 167648830 Common - Glutamate racemase Caul_4875 188 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 167644130 Common - SMC domain protein Caul_0158 115 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 167647869 Nonpathogen - hypothetical protein Caul_3909 2 None None None 167647544 Common - protein of unknown function DUF329 Caul_3582 43 COG3024 COG3024, Uncharacterized protein conserved in bacteria Function unknown 167648661 Nonpathogen - hypothetical protein Caul_4706 1 None None None 167647193 Common - ketosteroid isomerase-like protein Caul_3231 21 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 167647994 Nonpathogen - Domain of unknown function DUF1857 Caul_4034 3 None None None 167645818 Common - Methyltransferase type 11 Caul_1854 82 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 167647394 Common - low molecular weight phosphotyrosine protein phosphatase Caul_3432 21 COG4551 COG4551, Predicted protein tyrosine phosphatase General function prediction only 167648284 Common - hypothetical protein Caul_4329 16 None None None 167644191 Nonpathogen - hypothetical protein Caul_0219 1 None None None 167647169 Common - beta-lactamase Caul_3207 102 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 167647864 Common - hypothetical protein Caul_3904 24 COG5448 COG5448, Uncharacterized conserved protein Function unknown 167646763 Common - undecaprenyl diphosphate synthase Caul_2801 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 167646188 Nonpathogen - RES domain protein Caul_2225 11 None None None 167646221 Common - hypothetical protein Caul_2259 2 None None None 167647990 Nonpathogen - hypothetical protein Caul_4030 1 None None None 167647949 Common - hypothetical protein Caul_3989 25 COG3656 COG3656, Predicted periplasmic protein Function unknown 167644717 Nonpathogen - BFD domain protein (2Fe-2S)-binding domain protein Caul_0751 5 COG2906 Bfd, Bacterioferritin-associated ferredoxin Inorganic ion transport and metabolism 167648823 Common - Diaminopimelate epimerase Caul_4868 189 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 167646728 Nonpathogen - preprotein translocase, SecG subunit Caul_2766 1 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 167645629 Nonpathogen - hypothetical protein Caul_1665 1 None None None 167643992 Common - Scaffold protein Nfu/NifU Caul_0019 91 COG0694 COG0694, Thioredoxin-like proteins and domains Posttranslational modification, protein turnover, chaperones 167648270 Common - Extradiol ring-cleavage dioxygenase class III protein subunit B Caul_4315 86 COG3384 COG3384, Uncharacterized conserved protein Function unknown 167644833 Common - MotA/TolQ/ExbB proton channel Caul_0867 96 COG1291 MotA, Flagellar motor component Cell motility and secretion 167644174 Common - GCN5-related N-acetyltransferase Caul_0202 99 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 167648996 Common - phosphoribosyl-ATP diphosphatase Caul_5041 42 COG0140 HisI, Phosphoribosyl-ATP pyrophosphohydrolase Amino acid transport and metabolism 167648709 Nonpathogen - hypothetical protein Caul_4754 1 None None None 167645872 Common - TonB-dependent receptor plug Caul_1908 103 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167646829 Common - DNA topoisomerase IV, B subunit Caul_2867 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 167646609 Common - TonB-dependent receptor Caul_2647 103 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167645359 Common - alanyl-tRNA synthetase Caul_1394 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 167649032 Common - transcriptional regulator, MarR family Caul_5077 53 COG1846 MarR, Transcriptional regulators Transcription 167645114 Common - transcriptional regulator, XRE family Caul_1149 39 COG1396 HipB, Predicted transcriptional regulators Transcription 167644437 Nonpathogen - hypothetical protein Caul_0468 1 None None None 167648171 Common - protein of unknown function DUF214 Caul_4212 41 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 167648279 Common - hypothetical protein Caul_4324 6 None None None 167644113 Common - Lipocalin family protein Caul_0140 30 COG3040 Blc, Bacterial lipocalin Cell envelope biogenesis, outer membrane 167644517 Common - putative lipoprotein Caul_0548 13 None None None 167647407 Nonpathogen - transcriptional regulator, TetR family Caul_3445 4 COG1309 AcrR, Transcriptional regulator Transcription 167646364 Common - hypothetical protein Caul_2402 29 COG0657 Aes, Esterase/lipase Lipid metabolism 167644145 Common - oxygen-independent coproporphyrinogen III oxidase Caul_0173 202 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 167645219 Nonpathogen - hypothetical protein Caul_1254 1 None None None 167644777 Common - PAS/PAC sensor hybrid histidine kinase Caul_0811 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167646226 Common - hypothetical protein Caul_2264 27 COG4938 COG4938, Uncharacterized conserved protein Function unknown 167644679 Common - cobalt chelatase, pCobS small subunit Caul_0711 58 COG0714 COG0714, MoxR-like ATPases General function prediction only 167647523 Common - tryptophan halogenase Caul_3561 16 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 167645505 Common - Alcohol dehydrogenase GroES domain protein Caul_1540 204 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 167644922 Common - 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase Caul_0957 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 167646495 Nonpathogen - hypothetical protein Caul_2533 2 None None None 167644766 Nonpathogen - hypothetical protein Caul_0800 1 None None None 167647953 Nonpathogen - hypothetical protein Caul_3993 1 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 167648881 Nonpathogen - hypothetical protein Caul_4926 2 None None None 167645138 Common - signal transduction histidine kinase Caul_1173 85 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 167648587 Nonpathogen - hypothetical protein Caul_4632 1 None None None 167644983 Nonpathogen - hypothetical protein Caul_1018 1 None None None 167647929 Common - two component transcriptional regulator, winged helix family Caul_3969 219 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167644276 Common - Inosine/uridine-preferring nucleoside hydrolase Caul_0304 86 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 167648602 Common - HAD-superfamily hydrolase, phosphatase Caul_4647 21 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 167644419 Common - MaoC domain protein dehydratase Caul_0447 66 COG2030 MaoC, Acyl dehydratase Lipid metabolism 167645249 Common - GntR domain protein Caul_1284 88 COG2186 FadR, Transcriptional regulators Transcription 167646527 Common - acetyl-CoA carboxylase, biotin carboxyl carrier protein Caul_2565 181 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 167648592 Common - PilT protein domain protein Caul_4637 13 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 167648236 Nonpathogen - TonB family protein Caul_4280 1 None None None 167648702 Common - protein of unknown function DUF477 Caul_4747 87 COG1512 COG1512, Beta-propeller domains of methanol dehydrogenase type General function prediction only 167646177 Common - hypothetical protein Caul_2214 26 COG3686 COG3686, Predicted membrane protein Function unknown 167646296 Common - Oxidoreductase FAD-binding domain protein Caul_2334 185 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 167648379 Common - tRNA(Ile)-lysidine synthetase Caul_4424 10 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 167648258 Common - N-acetylneuraminate synthase Caul_4303 78 COG2089 SpsE, Sialic acid synthase Cell envelope biogenesis, outer membrane 167648504 Common - phosphate ABC transporter, inner membrane subunit PstA Caul_4549 231 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 167648159 Common - aminotransferase class IV Caul_4200 126 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 167648208 Common - putative transcriptional regulator, ArsR family Caul_4252 59 COG0640 ArsR, Predicted transcriptional regulators Transcription 167645993 Common - CagE TrbE VirB component of type IV transporter system Caul_2030 62 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 167645100 Common - AMP-dependent synthetase and ligase Caul_1135 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167647207 Common - glucose-methanol-choline oxidoreductase Caul_3245 89 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 167648168 Common - ATPase, P-type (transporting), HAD superfamily, subfamily IC Caul_4209 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 167648404 Common - urea carboxylase Caul_4449 226 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 167647230 Common - hypothetical protein Caul_3268 19 None None None 167647982 Common - lipolytic protein G-D-S-L family Caul_4022 16 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 167647001 Common - TrkA-C domain protein Caul_3039 102 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 167645211 Nonpathogen - hypothetical protein Caul_1246 1 COG5373 COG5373, Predicted membrane protein Function unknown 167644055 Common - Superoxide dismutase Caul_0082 202 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 167647311 Common - tRNA delta(2)-isopentenylpyrophosphate transferase Caul_3349 214 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 167645019 Nonpathogen - hypothetical protein Caul_1054 1 None None None 167644584 Common - CheW protein Caul_0616 127 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 167646577 Nonpathogen - hypothetical protein Caul_2615 3 None None None 167644533 Common - IstB domain protein ATP-binding protein Caul_0565 92 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 167646513 Common - Polyphosphate kinase Caul_2551 161 COG0855 Ppk, Polyphosphate kinase Inorganic ion transport and metabolism 167644807 Common - transposase IS3/IS911 family protein Caul_0841 44 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646420 Common - CoA-binding domain protein Caul_2458 186 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 167647039 Nonpathogen - protein of unknown function DUF1486 Caul_3077 6 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 167648109 Common - chaperonin GroEL Caul_4150 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 167645734 Common - virulence factor family protein Caul_1770 19 COG3946 VirJ, Type IV secretory pathway, VirJ component Intracellular trafficking and secretion 167644693 Common - PhnA protein Caul_0725 106 COG2824 PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism Inorganic ion transport and metabolism 167645658 Common - Carboxylesterase type B Caul_1694 55 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 167648552 Common - phosphoglucosamine mutase Caul_4597 241 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 167647944 Common - transcriptional regulator, TetR family Caul_3984 40 COG3226 COG3226, Uncharacterized protein conserved in bacteria Function unknown 167649007 Common - heat shock protein HslVU, ATPase subunit HslU Caul_5052 210 COG1220 HslU, ATP-dependent protease HslVU (ClpYQ), ATPase subunit Posttranslational modification, protein turnover, chaperones 167645028 Common - 67 kDa myosin-cross-reactive antigen family protein Caul_1063 25 COG4716 COG4716, Myosin-crossreactive antigen Function unknown 167644379 Common - transcriptional regulator, AraC family Caul_0407 114 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 167646897 Nonpathogen - hypothetical protein Caul_2935 1 None None None 167647780 Common - hypothetical protein Caul_3819 15 None None None 167647825 Common - nitrate reductase, alpha subunit Caul_3864 116 COG5013 NarG, Nitrate reductase alpha subunit Energy production and conversion 167647552 Common - NCS1 nucleoside transporter family Caul_3590 70 COG1953 FUI1, Cytosine/uracil/thiamine/allantoin permeases Nucleotide transport and metabolism / Coenzyme metabolism 167647400 Common - major facilitator superfamily MFS_1 Caul_3438 150 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167647386 Common - von Willebrand factor type A Caul_3424 74 COG2304 COG2304, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 167648947 Common - hypothetical protein Caul_4992 30 None None None 167647138 Common - Endoribonuclease L-PSP Caul_3176 58 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 167646431 Nonpathogen - hypothetical protein Caul_2469 7 None None None 167645533 Nonpathogen - hypothetical protein Caul_1568 2 None None None 167647950 Common - hypothetical protein Caul_3990 25 COG5266 CbiK, ABC-type Co2+ transport system, periplasmic component Inorganic ion transport and metabolism 167644475 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Caul_0506 222 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 167645175 Common - phosphoglycerate mutase 1 family Caul_1210 160 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 167645163 Common - glycosyl transferase group 1 Caul_1198 207 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 167646997 Common - hypothetical protein Caul_3035 22 None None None 167648062 Common - FF domain protein Caul_4103 25 COG3687 COG3687, Predicted metal-dependent hydrolase General function prediction only 167644143 Common - Glutathione S-transferase domain Caul_0171 63 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167645294 Common - protein of unknown function DUF140 Caul_1329 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 167647116 Common - Propionyl-CoA carboxylase Caul_3154 143 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 167647437 Nonpathogen - hypothetical protein Caul_3475 1 None None None 167646340 Nonpathogen - hypothetical protein Caul_2378 1 None None None 167644404 Common - protein of unknown function DUF336 Caul_0432 21 COG3193 GlcG, Uncharacterized protein, possibly involved in utilization of glycolate and propanediol General function prediction only 167647738 Common - short-chain dehydrogenase/reductase SDR Caul_3776 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167646231 Common - Conjugal transfer protein TrbC Caul_2269 22 COG3838 VirB2, Type IV secretory pathway, VirB2 components (pilins) Intracellular trafficking and secretion 167646107 Common - tryptophan halogenase Caul_2144 16 COG0579 COG0579, Predicted dehydrogenase General function prediction only 167644918 Nonpathogen - hypothetical protein Caul_0953 1 None None None 167645298 Common - transcriptional regulator, TetR family Caul_1333 38 COG1309 AcrR, Transcriptional regulator Transcription 167645705 Common - transcriptional regulator, MarR family Caul_1741 103 COG1846 MarR, Transcriptional regulators Transcription 167646224 Common - hypothetical protein Caul_2262 2 None None None 167644476 Common - 3-isopropylmalate dehydratase, large subunit Caul_0507 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 167646660 Common - DNA polymerase III, delta prime subunit Caul_2698 196 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 167644058 Nonpathogen - 17 kDa surface antigen Caul_0085 1 COG3134 COG3134, Predicted outer membrane lipoprotein Function unknown 167644301 Common - transcriptional regulator, XRE family Caul_0329 42 COG1396 HipB, Predicted transcriptional regulators Transcription 167646415 Nonpathogen - hypothetical protein Caul_2453 1 None None None 167646693 Common - transcriptional regulator, ModE family Caul_2731 86 COG2005 ModE, N-terminal domain of molybdenum-binding protein General function prediction only 167644018 Common - 2OG-Fe(II) oxygenase Caul_0045 44 COG3128 PiuC, Uncharacterized iron-regulated protein Function unknown 167646793 Common - NADH-quinone oxidoreductase, E subunit Caul_2831 155 COG1905 NuoE, NADH:ubiquinone oxidoreductase 24 kD subunit Energy production and conversion 167644009 Common - Tetratricopeptide TPR_2 repeat protein Caul_0036 9 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 167647246 Common - putative signal transduction protein with EFhand domain Caul_3284 16 COG5126 FRQ1, Ca2+-binding protein (EF-Hand superfamily) Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only 167647430 Common - Recombinase Caul_3468 36 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 167646087 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_2124 55 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167648616 Common - ribonucleoside-diphosphate reductase, alpha subunit Caul_4661 221 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 167644197 Common - transcriptional regulator, TetR family Caul_0225 75 COG1309 AcrR, Transcriptional regulator Transcription 167645431 Common - transcriptional regulator, LysR family Caul_1466 172 COG0583 LysR, Transcriptional regulator Transcription 167645976 Common - protein of unknown function DUF736 Caul_2013 18 COG5489 COG5489, Uncharacterized conserved protein Function unknown 167647410 Common - hypothetical protein Caul_3448 15 None None None 167648926 Common - transposase IS3/IS911 family protein Caul_4971 44 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646669 Common - L-carnitine dehydratase/bile acid-inducible protein F Caul_2707 115 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 167644500 Common - transcriptional regulator, TetR family Caul_0531 109 COG1309 AcrR, Transcriptional regulator Transcription 167645894 Common - major facilitator superfamily MFS_1 Caul_1930 175 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 167647341 Common - SCP-like extracellular Caul_3379 10 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 167646115 Common - beta-lactamase Caul_2152 140 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 167648417 Common - hypothetical protein Caul_4462 60 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 167644513 Common - putative thermostable hemolysin Caul_0544 16 None None None 167646674 Common - glucose-1-phosphate cytidylyltransferase Caul_2712 162 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 167648201 Common - transposase IS4 family protein Caul_4244 50 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 167645264 Common - formiminoglutamate deiminase Caul_1299 109 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 167647554 Common - Peptidase M1 membrane alanine aminopeptidase Caul_3592 161 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 167645758 Common - hypothetical protein Caul_1794 17 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 167644639 Common - ribose-phosphate pyrophosphokinase Caul_0671 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 167648079 Common - transposase, IS4 family protein Caul_4120 10 None None None 167647845 Common - integral membrane sensor signal transduction histidine kinase Caul_3885 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167646936 Common - UspA domain protein Caul_2974 35 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 167644800 Common - transcriptional regulator, XRE family Caul_0834 44 COG1396 HipB, Predicted transcriptional regulators Transcription 167648069 Common - response regulator receiver protein Caul_4110 15 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 167645412 Common - acyl-CoA dehydrogenase domain protein Caul_1447 147 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167645538 Nonpathogen - hypothetical protein Caul_1573 3 None None None 167646875 Common - aminoglycoside phosphotransferase Caul_2913 57 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 167644177 Common - Lysine exporter protein (LYSE/YGGA) Caul_0205 115 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 167644821 Common - Protein of unknown function DUF1971 Caul_0855 47 COG2346 COG2346, Truncated hemoglobins General function prediction only 167648784 Common - glycosyl transferase, WecB/TagA/CpsF family Caul_4829 108 COG1922 WecG, Teichoic acid biosynthesis proteins Cell envelope biogenesis, outer membrane 167645501 Common - polysaccharide deacetylase Caul_1536 15 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 167644940 Common - transcriptional regulator, GntR family with aminotransferase domain Caul_0975 168 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 167648367 Common - short-chain dehydrogenase/reductase SDR Caul_4412 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167645462 Common - response regulator receiver modulated diguanylate cyclase Caul_1497 223 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 167647465 Nonpathogen - hypothetical protein Caul_3503 1 None None None 167646782 Common - proton-translocating NADH-quinone oxidoreductase, chain M Caul_2820 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 167648895 Common - glycosyl transferase family 2 Caul_4940 98 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 167646607 Common - ThiJ/PfpI domain protein Caul_2645 108 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 167644536 Nonpathogen - hypothetical protein Caul_0568 1 None None None 167645889 Common - short-chain dehydrogenase/reductase SDR Caul_1925 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167648339 Common - Glycine dehydrogenase (decarboxylating) Caul_4384 172 COG0403 GcvP, Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain Amino acid transport and metabolism 167648355 Common - protein of unknown function DUF302 Caul_4400 43 COG3439 COG3439, Uncharacterized conserved protein Function unknown 167645407 Common - transcriptional regulator, LacI family Caul_1442 128 COG1609 PurR, Transcriptional regulators Transcription 167647557 Nonpathogen - hypothetical protein Caul_3595 2 None None None 167647685 Common - cold-shock DNA-binding domain protein Caul_3723 170 COG1278 CspC, Cold shock proteins Transcription 167647137 Common - thiamine biosynthesis protein ThiC Caul_3175 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 167647810 Common - hypothetical protein Caul_3849 53 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167644809 Common - plasmid stabilization system Caul_0843 32 COG3668 ParE, Plasmid stabilization system protein General function prediction only 167648030 Common - hypothetical protein Caul_4070 4 None None None 167648107 Nonpathogen - hypothetical protein Caul_4148 1 None None None 167647048 Common - dihydrodipicolinate synthase Caul_3086 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 167645693 Common - 2-dehydro-3-deoxyphosphooctonate aldolase Caul_1729 155 COG2877 KdsA, 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase Cell envelope biogenesis, outer membrane 167648566 Common - Xylose isomerase domain protein TIM barrel Caul_4611 49 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 167647752 Common - molybdopterin binding domain Caul_3791 165 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 167645653 Common - polysaccharide biosynthesis protein Caul_1689 10 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 167647323 Common - Peptidase C13, legumain asparaginyl peptidase Caul_3361 12 None None None 167645058 Nonpathogen - hypothetical protein Caul_1093 1 None None None 167646798 Common - NADH-ubiquinone/plastoquinone oxidoreductase chain 3 Caul_2836 161 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 167644947 Common - GCN5-related N-acetyltransferase Caul_0982 15 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 167646062 Common - hypothetical protein Caul_2099 4 COG3156 PulK, Type II secretory pathway, component PulK Intracellular trafficking and secretion 167648532 Common - protein of unknown function DUF1123 Caul_4577 15 COG5331 COG5331, Uncharacterized protein conserved in bacteria Function unknown 167646332 Common - putative esterase Caul_2370 13 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 167646794 Common - hypothetical protein Caul_2832 12 COG4538 COG4538, Uncharacterized conserved protein Function unknown 167648950 Common - 2'-5' RNA ligase Caul_4995 113 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 167645523 Nonpathogen - hypothetical protein Caul_1558 2 None None None 167645367 Common - hypothetical protein Caul_1402 6 None None None 167646399 Common - cytochrome c oxidase, cbb3-type, subunit I Caul_2437 133 COG3278 CcoN, Cbb3-type cytochrome oxidase, subunit 1 Posttranslational modification, protein turnover, chaperones 167646213 Common - Lytic transglycosylase catalytic Caul_2251 137 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 167644246 Common - acyl-CoA dehydrogenase domain protein Caul_0274 167 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167646970 Common - ETC complex I subunit conserved region Caul_3008 37 None None None 167645335 Common - short-chain dehydrogenase/reductase SDR Caul_1370 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167647900 Common - amino acid permease-associated region Caul_3940 179 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 167647602 Common - DNA topoisomerase, type I, putative Caul_3640 45 COG3569 COG3569, Topoisomerase IB DNA replication, recombination, and repair 167648410 Common - molybdenum cofactor synthesis domain protein Caul_4455 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 167646197 Common - protein of unknown function DUF736 Caul_2235 25 COG5489 COG5489, Uncharacterized conserved protein Function unknown 167645414 Nonpathogen - hypothetical protein Caul_1449 1 None None None 167646927 Nonpathogen - hypothetical protein Caul_2965 1 None None None 167648473 Nonpathogen - hypothetical protein Caul_4518 2 None None None 167646843 Nonpathogen - hypothetical protein Caul_2881 1 COG3494 COG3494, Uncharacterized protein conserved in bacteria Function unknown 167647919 Common - peptidase M50 Caul_3959 8 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 167644484 Common - alpha/beta hydrolase fold Caul_0515 62 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167645428 Common - hypothetical protein Caul_1463 10 COG4321 COG4321, Uncharacterized protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis General function prediction only 167648718 Common - Argininosuccinate synthase Caul_4763 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 167644107 Nonpathogen - hypothetical protein Caul_0134 1 None None None 167648445 Common - Redoxin domain protein Caul_4490 87 COG0678 AHP1, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 167648599 Common - AsmA family protein Caul_4644 64 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 167645251 Common - KDPG and KHG aldolase Caul_1286 124 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 167644630 Common - RNA polymerase, sigma 32 subunit, RpoH Caul_0662 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 167646775 Common - protein of unknown function DUF1467 Caul_2813 14 COG5454 COG5454, Predicted secreted protein Function unknown 167645618 Common - pseudouridine synthase Caul_1654 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 167646945 Common - UspA domain protein Caul_2983 27 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 167645044 Common - CBS sensor hybrid histidine kinase Caul_1079 217 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 167648712 Common - cysteine synthase A Caul_4757 219 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 167648921 Nonpathogen - hypothetical protein Caul_4966 8 None None None 167644775 Common - transcriptional regulator, MarR family Caul_0809 37 COG1846 MarR, Transcriptional regulators Transcription 167648129 Nonpathogen - hypothetical protein Caul_4170 1 None None None 167644562 Common - transposase, IS4 Caul_0594 14 None None None 167644929 Common - Levansucrase Caul_0964 16 None None None 167645445 Common - NADPH-dependent FMN reductase Caul_1480 116 COG0431 COG0431, Predicted flavoprotein General function prediction only 167648368 Nonpathogen - hypothetical protein Caul_4413 1 None None None 167648035 Common - Chloride channel core Caul_4075 23 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 167648291 Nonpathogen - hypothetical protein Caul_4336 1 None None None 167644325 Common - transcriptional regulator/antitoxin, MazE Caul_0353 5 COG2336 MazE, Growth regulator Signal transduction mechanisms 167645926 Common - Patatin Caul_1962 11 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 167648857 Common - DegT/DnrJ/EryC1/StrS aminotransferase Caul_4902 192 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 167644448 Common - TRAG family protein Caul_0479 63 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 167644740 Common - putative addiction module antidote protein, CopG/Arc/MetJ family Caul_0774 9 COG3609 COG3609, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain Transcription 167644461 Common - alpha/beta hydrolase fold Caul_0492 121 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167649024 Common - deoxyuridine 5'-triphosphate nucleotidohydrolase Dut Caul_5069 179 COG0756 Dut, dUTPase Nucleotide transport and metabolism 167648883 Common - methyltransferase FkbM family Caul_4928 20 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 167648937 Common - periplasmic protein thiol--disulphide oxidoreductase DsbE Caul_4982 142 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 167648984 Nonpathogen - hypothetical protein Caul_5029 15 COG5468 COG5468, Predicted secreted (periplasmic) protein Function unknown 167648089 Common - hypothetical protein Caul_4130 8 None None None 167646977 Common - Homoserine dehydrogenase Caul_3015 204 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 167648120 Common - RTX toxin-activating protein C Caul_4161 8 COG2994 HlyC, ACP:hemolysin acyltransferase (hemolysin-activating protein) Posttranslational modification, protein turnover, chaperones 167648964 Common - exodeoxyribonuclease III Xth Caul_5009 194 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 167648387 Common - hypothetical protein Caul_4432 17 COG3742 COG3742, Uncharacterized protein conserved in bacteria Function unknown 167648727 Common - hypothetical protein Caul_4772 23 COG5642 COG5642, Uncharacterized conserved protein Function unknown 167645074 Common - transposase and inactivated derivative Caul_1109 70 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646314 Common - copper-resistance protein, CopA family Caul_2352 126 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 167643990 Nonpathogen - hypothetical protein Caul_0017 1 None None None 167644015 Common - ribonuclease T2 Caul_0042 35 COG3719 Rna, Ribonuclease I Translation, ribosomal structure and biogenesis 167644298 Common - Ti-type conjugative transfer relaxase TraA Caul_0326 126 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 167646238 Common - conjugation TrbI family protein Caul_2276 57 COG2948 VirB10, Type IV secretory pathway, VirB10 components Intracellular trafficking and secretion 167648822 Common - short-chain dehydrogenase/reductase SDR Caul_4867 221 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 167646880 Common - ADP-L-glycero-D-manno-heptose-6-epimerase Caul_2918 227 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167647030 Common - transcriptional regulator, TetR family Caul_3068 13 COG1309 AcrR, Transcriptional regulator Transcription 167646080 Nonpathogen - transcriptional regulator, AraC family Caul_2117 2 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 167644185 Common - 3-isopropylmalate dehydrogenase Caul_0213 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 167646002 Common - phospholipase/Carboxylesterase Caul_2039 103 COG0400 COG0400, Predicted esterase General function prediction only 167645395 Common - flagellar basal body P-ring formation protein FlgA Caul_1430 36 COG1261 FlgA, Flagellar basal body P-ring biosynthesis protein Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 167647615 Common - 4-hydroxyphenylpyruvate dioxygenase Caul_3653 77 COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins Amino acid transport and metabolism / General function prediction only 167644681 Common - phosphoesterase PA-phosphatase related Caul_0713 41 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 167644963 Common - transcriptional regulator, LysR family Caul_0998 166 COG0583 LysR, Transcriptional regulator Transcription 167646960 Common - transcriptional regulator, XRE family Caul_2998 44 COG3800 COG3800, Predicted transcriptional regulator General function prediction only 167645683 Common - NAD(+) kinase Caul_1719 233 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 167646166 Common - succinylglutamic semialdehyde dehydrogenase Caul_2203 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167647218 Common - hypothetical protein Caul_3256 18 COG3828 COG3828, Uncharacterized protein conserved in bacteria Function unknown 167648229 Nonpathogen - hypothetical protein Caul_4273 1 COG3371 COG3371, Predicted membrane protein Function unknown 167647210 Common - Enoyl-CoA hydratase/isomerase Caul_3248 165 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 167644352 Common - nitrogen regulatory protein P-II Caul_0380 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 167645826 Common - TonB-dependent receptor plug Caul_1862 29 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167644392 Common - hypothetical protein Caul_0420 4 None None None 167647050 Common - ABC transporter related Caul_3088 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 167647743 Common - iron-containing alcohol dehydrogenase Caul_3781 174 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 167644284 Common - transcriptional regulator, DeoR family Caul_0312 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 167644608 Common - 60 kDa inner membrane insertion protein Caul_0640 214 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 167645302 Common - RND efflux system, outer membrane lipoprotein, NodT family Caul_1337 116 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 167646052 Common - general secretory pathway protein E Caul_2089 216 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 167646165 Common - arginine/ornithine succinyltransferase subunit Caul_2202 37 COG3138 AstA, Arginine/ornithine N-succinyltransferase beta subunit Amino acid transport and metabolism 167644794 Common - DGPFAETKE family protein Caul_0828 24 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 167647537 Common - TonB family protein Caul_3575 3 None None None 167647143 Common - aspartate racemase Caul_3181 82 COG1794 RacX, Aspartate racemase Cell envelope biogenesis, outer membrane 167648845 Common - hypothetical protein Caul_4890 15 None None None 167647608 Common - flagellin domain protein Caul_3646 118 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 167647973 Common - Carboxylesterase type B Caul_4013 78 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 167645880 Common - aromatic-ring-hydroxylating dioxygenase beta subunit Caul_1916 19 COG5517 COG5517, Small subunit of phenylpropionate dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 167646035 Nonpathogen - SMP-30/Gluconolaconase/LRE domain protein Caul_2072 11 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 167647067 Common - hypothetical protein Caul_3105 17 COG3748 COG3748, Predicted membrane protein Function unknown 167648639 Common - filamentation induced by cAMP protein Fic Caul_4684 32 COG2184 Fic, Protein involved in cell division Cell division and chromosome partitioning 167645713 Common - sulfate adenylyltransferase, large subunit Caul_1749 249 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 167645943 Common - hypothetical protein Caul_1980 13 None None None 167644200 Common - polysaccharide deacetylase Caul_0228 222 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 167647144 Nonpathogen - hypothetical protein Caul_3182 6 None None None 167645082 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Caul_1117 36 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 167645748 Common - phosphate ABC transporter, periplasmic phosphate-binding protein PstS, putative Caul_1784 120 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 167647839 Common - (Glutamate--ammonia-ligase) adenylyltransferase Caul_3878 119 COG1391 GlnE, Glutamine synthetase adenylyltransferase Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms 167646920 Common - nitrate transporter Caul_2958 80 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 167645306 Common - transcriptional regulator, MucR family Caul_1341 33 COG4957 COG4957, Predicted transcriptional regulator Transcription 167645386 Common - hemerythrin HHE cation binding region protein Caul_1421 27 None None None 167647708 Common - protein of unknown function DUF1457 Caul_3746 15 COG5388 COG5388, Uncharacterized protein conserved in bacteria Function unknown 167648935 Nonpathogen - hypothetical protein Caul_4980 1 None None None 167643977 Common - chaperone protein DnaK Caul_0004 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 167646980 Common - poly(R)-hydroxyalkanoic acid synthase, class I Caul_3018 75 COG3243 PhaC, Poly(3-hydroxyalkanoate) synthetase Lipid metabolism 167647416 Common - PilT protein domain protein Caul_3454 17 COG3742 COG3742, Uncharacterized protein conserved in bacteria Function unknown 167644733 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Caul_0767 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 167646890 Common - transcriptional repressor, CopY family Caul_2928 20 COG3682 COG3682, Predicted transcriptional regulator Transcription 167647293 Common - response regulator receiver protein Caul_3331 64 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 167647174 Nonpathogen - hypothetical protein Caul_3212 1 None None None 167647663 Nonpathogen - hypothetical protein Caul_3701 1 None None None 167646044 Common - glycosyl transferase group 1 Caul_2081 101 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 167646502 Common - hypothetical protein Caul_2540 31 None None None 167648672 Common - gamma-glutamyl phosphate reductase Caul_4717 187 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 167647876 Common - phage portal protein, HK97 family Caul_3916 60 COG4695 COG4695, Phage-related protein Function unknown 167645790 Nonpathogen - hypothetical protein Caul_1826 1 None None None 167644958 Common - short-chain dehydrogenase/reductase SDR Caul_0993 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167645934 Common - TonB-dependent receptor Caul_1970 60 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 167644550 Common - dehydrogenase E1 component Caul_0582 154 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 167644575 Common - Resolvase domain Caul_0607 27 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 167646562 Common - hypothetical protein Caul_2600 8 None None None 167648267 Common - response regulator receiver protein Caul_4312 198 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 167646645 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_2683 140 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167648775 Common - Undecaprenyl-phosphate galactose phosphotransferase Caul_4820 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 167644525 Common - Amine dehydrogenase Caul_0557 11 None None None 167644909 Nonpathogen - 17 kDa surface antigen Caul_0943 1 COG3134 COG3134, Predicted outer membrane lipoprotein Function unknown 167648025 Nonpathogen - hypothetical protein Caul_4065 1 None None None 167647512 Common - putative glutathione S-transferase Caul_3550 12 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167646531 Common - hypothetical protein Caul_2569 4 None None None 167644135 Common - peptide methionine sulfoxide reductase Caul_0163 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 167644975 Common - protein of unknown function DUF1078 domain protein Caul_1010 127 COG1749 FlgE, Flagellar hook protein FlgE Cell motility and secretion 167645724 Common - KDPG and KHG aldolase Caul_1760 126 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 167645667 Nonpathogen - hypothetical protein Caul_1703 1 None None None 167645989 Common - CopG domain protein DNA-binding domain protein Caul_2026 23 None None None 167647128 Common - methionine-R-sulfoxide reductase Caul_3166 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 167644649 Common - Activator of Hsp90 ATPase 1 family protein Caul_0681 19 COG3832 COG3832, Uncharacterized conserved protein Function unknown 167645634 Common - outer membrane autotransporter barrel domain protein Caul_1670 27 COG0536 Obg, Predicted GTPase General function prediction only 167647909 Common - Ornithine carbamoyltransferase Caul_3949 200 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 167645660 Common - beta-ketoadipyl CoA thiolase Caul_1696 168 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167648484 Common - cysteinyl-tRNA synthetase Caul_4529 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 167646623 Common - class II aldolase/adducin family protein Caul_2661 115 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 167646069 Common - Biopolymer transport protein ExbD/TolR Caul_2106 124 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 167648429 Common - protein of unknown function DUF925 Caul_4474 26 COG3575 COG3575, Uncharacterized protein conserved in bacteria Function unknown 167645198 Common - hypothetical protein Caul_1233 21 COG5460 COG5460, Uncharacterized conserved protein Function unknown 167647596 Nonpathogen - hypothetical protein Caul_3634 1 None None None 167644388 Common - transcriptional regulator, LacI family Caul_0416 129 COG1609 PurR, Transcriptional regulators Transcription 167648630 Common - nuclear export factor GLE1 Caul_4675 27 COG4549 COG4549, Uncharacterized protein conserved in bacteria Function unknown 167646590 Common - transcriptional regulator, XRE family Caul_2628 15 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 167644641 Common - protein of unknown function DUF185 Caul_0673 85 COG1565 COG1565, Uncharacterized conserved protein Function unknown 167648301 Nonpathogen - hypothetical protein Caul_4346 1 None None None 167645933 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_1969 48 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167645745 Common - Peptidoglycan-binding domain 1 protein Caul_1781 74 COG2989 COG2989, Uncharacterized protein conserved in bacteria Function unknown 167648186 Common - Integrase catalytic region Caul_4229 146 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 167648180 Common - PepSY-associated TM helix domain protein Caul_4221 17 None None None 167645202 Common - histidine kinase Caul_1237 220 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 167646422 Common - response regulator receiver protein Caul_2460 124 COG4566 TtrR, Response regulator Signal transduction mechanisms 167648010 Common - HAD-superfamily subfamily IIA hydrolase like protein Caul_4050 60 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 167644600 Common - ABC transporter related Caul_0632 142 COG4987 CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 167648346 Common - hydroxymethylbutenyl pyrophosphate reductase Caul_4391 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 167647713 Common - hypothetical protein Caul_3751 13 None None None 167647635 Common - Peptidoglycan glycosyltransferase Caul_3673 206 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 167646525 Common - Leucyltransferase Caul_2563 134 COG2360 Aat, Leu/Phe-tRNA-protein transferase Posttranslational modification, protein turnover, chaperones 167644383 Common - transcriptional regulator, MerR family Caul_0411 22 COG0789 SoxR, Predicted transcriptional regulators Transcription 167645457 Common - penicillin-binding protein 2 Caul_1492 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 167645909 Common - transcriptional regulator, TetR family Caul_1945 61 COG1309 AcrR, Transcriptional regulator Transcription 167647257 Common - hypothetical protein Caul_3295 10 None None None 167646742 Nonpathogen - Isoprenylcysteine carboxyl methyltransferase Caul_2780 1 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 167646547 Common - hypothetical protein Caul_2585 87 COG2945 COG2945, Predicted hydrolase of the alpha/beta superfamily General function prediction only 167645181 Common - hypothetical protein Caul_1216 21 COG4798 COG4798, Predicted methyltransferase General function prediction only 167648628 Nonpathogen - hypothetical protein Caul_4673 1 None None None 167646599 Common - transglutaminase domain protein Caul_2637 82 COG4196 COG4196, Uncharacterized protein conserved in bacteria Function unknown 167646304 Nonpathogen - hypothetical protein Caul_2342 3 None None None 167645006 Common - transcriptional regulator, MarR family Caul_1041 71 COG0640 ArsR, Predicted transcriptional regulators Transcription 167645038 Nonpathogen - hypothetical protein Caul_1073 1 None None None 167647376 Common - ABC transporter related Caul_3414 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 167647977 Common - proline imino-peptidase Caul_4017 23 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167647475 Common - hypothetical protein Caul_3513 37 COG3809 COG3809, Uncharacterized protein conserved in bacteria Function unknown 167648003 Nonpathogen - hypothetical protein Caul_4043 1 None None None 167645609 Nonpathogen - hypothetical protein Caul_1645 10 COG3801 COG3801, Uncharacterized protein conserved in bacteria Function unknown 167644780 Common - AMP-dependent synthetase and ligase Caul_0814 221 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167646899 Common - glucose-methanol-choline oxidoreductase Caul_2937 47 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 167648609 Common - protein of unknown function DUF45 Caul_4654 127 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 167646358 Nonpathogen - hypothetical protein Caul_2396 4 COG1241 MCM2, Predicted ATPase involved in replication control, Cdc46/Mcm family DNA replication, recombination, and repair 167645326 Common - acyl-CoA dehydrogenase domain protein Caul_1361 149 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167648017 Common - isoleucyl-tRNA synthetase Caul_4057 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 167645556 Nonpathogen - hypothetical protein Caul_1591 1 None None None 167644420 Common - hypothetical protein Caul_0448 27 COG2030 MaoC, Acyl dehydratase Lipid metabolism 167646098 Common - ROK family protein Caul_2135 102 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 167648545 Common - thioredoxin Caul_4590 224 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 167648436 Common - 3-hydroxybutyrate dehydrogenase Caul_4481 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167646723 Common - Septum formation initiator Caul_2761 29 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 167645573 Common - formate dehydrogenase family accessory protein FdhD Caul_1609 137 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 167644691 Nonpathogen - hypothetical protein Caul_0723 2 None None None 167645228 Common - integral membrane sensor hybrid histidine kinase Caul_1263 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167647858 Common - transcriptional modulator of MazE/toxin, MazF Caul_3898 47 COG2337 MazF, Growth inhibitor Signal transduction mechanisms 167646704 Common - nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Caul_2742 118 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 167644169 Common - Biopolymer transport protein ExbD/TolR Caul_0197 102 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 167646322 Common - hypothetical protein Caul_2360 6 None None None 167645141 Common - hypothetical protein Caul_1176 14 None None None 167646751 Nonpathogen - hypothetical protein Caul_2789 4 None None None 167646651 Common - drug resistance transporter, EmrB/QacA subfamily Caul_2689 229 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167647830 Common - hypothetical protein Caul_3869 15 None None None 167645834 Common - 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) Caul_1870 153 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 167648253 Common - acylneuraminate cytidylyltransferase Caul_4298 22 COG1861 SpsF, Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog Cell envelope biogenesis, outer membrane 167644037 Common - alanine dehydrogenase Caul_0064 164 COG0686 Ald, Alanine dehydrogenase Amino acid transport and metabolism 167646835 Common - protein of unknown function DUF6 transmembrane Caul_2873 43 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 167646967 Common - peptidase U32 Caul_3005 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 167646538 Nonpathogen - hypothetical protein Caul_2576 3 None None None 167647917 Common - aminotransferase class-III Caul_3957 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 167647623 Common - peptidase M28 Caul_3661 17 COG2234 Iap, Predicted aminopeptidases General function prediction only 167648323 Common - A/G-specific adenine glycosylase Caul_4368 191 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 167645055 Nonpathogen - hypothetical protein Caul_1090 1 None None None 167647725 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Caul_3763 12 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 167644064 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_0091 128 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167645776 Nonpathogen - hypothetical protein Caul_1812 8 None None None 167644398 Common - oxidoreductase domain protein Caul_0426 96 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 167644496 Common - short-chain dehydrogenase/reductase SDR Caul_0527 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167647673 Common - Acetamidase/Formamidase Caul_3711 66 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 167646813 Common - Phosphoglycerate mutase Caul_2851 4 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 167646620 Common - ABC transporter related Caul_2658 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 167645603 Common - ribosomal protein L17 Caul_1639 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 167648144 Common - ABC transporter related Caul_4185 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 167645343 Common - TonB-dependent receptor Caul_1378 60 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167646849 Common - flagellin domain protein Caul_2887 115 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 167647314 Common - hypothetical protein Caul_3352 18 COG3514 COG3514, Uncharacterized protein conserved in bacteria Function unknown 167647588 Common - protein of unknown function UPF0016 Caul_3626 69 COG2119 COG2119, Predicted membrane protein Function unknown 167644812 Common - protein of unknown function DUF86 Caul_0846 42 COG2361 COG2361, Uncharacterized conserved protein Function unknown 167647226 Nonpathogen - hypothetical protein Caul_3264 1 None None None 167644874 Common - protein of unknown function DUF465 Caul_0908 37 COG5481 COG5481, Uncharacterized conserved small protein containing a coiled-coil domain Function unknown 167647701 Nonpathogen - hypothetical protein Caul_3739 1 None None None 167645864 Common - Carboxymuconolactone decarboxylase Caul_1900 21 COG2128 COG2128, Uncharacterized conserved protein Function unknown 167645131 Common - protein of unknown function DUF599 Caul_1166 22 COG3821 COG3821, Predicted membrane protein Function unknown 167647306 Common - HflK protein Caul_3344 145 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 167646511 Common - Ppx/GppA phosphatase Caul_2549 171 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 167648915 Common - sigma 54 modulation protein/ribosomal protein S30EA Caul_4960 51 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 167647103 Common - general stress protein Caul_3141 37 COG3871 COG3871, Uncharacterized stress protein (general stress protein 26) General function prediction only 167645577 Common - ribosomal protein S10 Caul_1613 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 167646291 Common - acyltransferase 3 Caul_2329 59 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 167644590 Common - histidine kinase Caul_0622 118 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 167644782 Common - adenosine deaminase Caul_0816 101 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 167646613 Common - amidohydrolase Caul_2651 136 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 167644129 Common - DNA gyrase, B subunit Caul_0157 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 167645963 Nonpathogen - hypothetical protein Caul_2000 7 None None None 167648117 Common - YD repeat protein Caul_4158 74 COG3209 RhsA, Rhs family protein Cell envelope biogenesis, outer membrane 167644514 Common - AMP-dependent synthetase and ligase Caul_0545 215 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 167646876 Nonpathogen - hypothetical protein Caul_2914 1 None None None 167644674 Common - dienelactone hydrolase Caul_0706 87 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 167646846 Common - flagellin domain protein Caul_2884 125 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 167644985 Common - transcriptional regulator, XRE family Caul_1020 41 COG1396 HipB, Predicted transcriptional regulators Transcription 167647224 Common - 3D domain protein Caul_3262 3 COG3584 COG3584, Uncharacterized protein conserved in bacteria Function unknown 167648054 Common - protein of unknown function DUF214 Caul_4095 177 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 167646516 Common - protein of unknown function DUF262 Caul_2554 29 COG1479 COG1479, Uncharacterized conserved protein Function unknown 167644615 Common - flavin-containing monooxygenase FMO Caul_0647 74 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 167645127 Nonpathogen - adenylate kinase-like protein Caul_1162 2 COG2019 AdkA, Archaeal adenylate kinase Nucleotide transport and metabolism 167645544 Nonpathogen - hypothetical protein Caul_1579 1 None None None 167646306 Common - two component transcriptional regulator, LuxR family Caul_2344 222 COG4566 TtrR, Response regulator Signal transduction mechanisms 167647801 Common - anti-ECFsigma factor, ChrR Caul_3840 28 COG3806 ChrR, Transcriptional activator Transcription 167648177 Nonpathogen - hypothetical protein Caul_4218 1 None None None 167646032 Common - GntR domain protein Caul_2069 112 COG2186 FadR, Transcriptional regulators Transcription 167646597 Common - transglutaminase domain protein Caul_2635 93 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 167647316 Nonpathogen - hypothetical protein Caul_3354 1 None None None 167647942 Common - luciferase family protein Caul_3982 69 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 167645242 Common - ABC transporter related Caul_1277 249 COG4181 COG4181, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 167648590 Nonpathogen - hypothetical protein Caul_4635 2 None None None 167645275 Nonpathogen - hypothetical protein Caul_1310 1 None None None 167645124 Common - hypothetical protein Caul_1159 6 None None None 167646439 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Caul_2477 57 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 167648979 Common - glucose inhibited division protein A Caul_5024 193 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 167644417 Common - L-carnitine dehydratase/bile acid-inducible protein F Caul_0445 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 167647726 Common - NLPA lipoprotein Caul_3764 100 COG1464 NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen Inorganic ion transport and metabolism 167644310 Common - DNA binding domain protein, excisionase family Caul_0338 31 None None None 167645619 Common - hypothetical protein Caul_1655 5 None None None 167647786 Common - TRAG family protein Caul_3825 76 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 167645378 Common - NUDIX hydrolase Caul_1413 26 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 167645440 Common - SCP-like extracellular Caul_1475 8 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 167646380 Common - Acid phosphatase Caul_2418 22 COG1409 Icc, Predicted phosphohydrolases General function prediction only 167648110 Common - chaperonin Cpn10 Caul_4151 216 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 167646991 Nonpathogen - Transglycosylase-associated protein Caul_3029 2 None None None 167644586 Common - response regulator receiver modulated CheB methylesterase Caul_0618 206 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 167644901 Common - major facilitator superfamily MFS_1 Caul_0935 117 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 167644373 Nonpathogen - hypothetical protein Caul_0401 1 None None None 167646601 Common - transglutaminase domain protein Caul_2639 87 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 167645292 Common - transcriptional regulator, TetR family Caul_1327 60 COG1309 AcrR, Transcriptional regulator Transcription 167646497 Nonpathogen - hypothetical protein Caul_2535 1 None None None 167645888 Common - short-chain dehydrogenase/reductase SDR Caul_1924 232 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 167645870 Common - Alcohol dehydrogenase zinc-binding domain protein Caul_1906 152 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 167646739 Common - anthranilate phosphoribosyltransferase Caul_2777 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 167644272 Common - prolipoprotein diacylglyceryl transferase Caul_0300 31 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 167646889 Common - protein of unknown function DUF1697 Caul_2927 29 COG3797 COG3797, Uncharacterized protein conserved in bacteria Function unknown 167644415 Common - Aldehyde Dehydrogenase_ Caul_0443 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167646398 Nonpathogen - hypothetical protein Caul_2436 1 None None None 167646298 Common - hypothetical protein Caul_2336 14 None None None 167646924 Common - agmatine deiminase Caul_2962 87 COG2957 COG2957, Peptidylarginine deiminase and related enzymes Amino acid transport and metabolism 167646753 Common - lipid-A-disaccharide synthase Caul_2791 139 COG0763 LpxB, Lipid A disaccharide synthetase Cell envelope biogenesis, outer membrane 167645991 Common - Conjugal transfer protein TrbC Caul_2028 28 COG3838 VirB2, Type IV secretory pathway, VirB2 components (pilins) Intracellular trafficking and secretion 167648402 Common - hypothetical protein Caul_4447 48 COG3665 COG3665, Uncharacterized conserved protein Function unknown 167647867 Common - hypothetical protein Caul_3907 5 None None None 167647837 Common - Ferric reductase domain protein transmembrane component domain Caul_3876 74 COG2717 COG2717, Predicted membrane protein Function unknown 167645102 Common - Vanillate monooxygenase Caul_1137 70 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 167646837 Common - 8-amino-7-oxononanoate synthase Caul_2875 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 167645013 Nonpathogen - hypothetical protein Caul_1048 1 None None None 167647362 Common - protein of unknown function DUF898 transmembrane Caul_3400 33 COG4269 COG4269, Predicted membrane protein Function unknown 167648047 Common - transcriptional regulator, LacI family Caul_4088 126 COG1609 PurR, Transcriptional regulators Transcription 167644102 Nonpathogen - hypothetical protein Caul_0129 1 None None None 167648040 Common - glycosyl hydrolase 53 domain protein Caul_4081 17 COG3867 COG3867, Arabinogalactan endo-1,4-beta-galactosidase Carbohydrate transport and metabolism 167644659 Common - major facilitator superfamily MFS_1 Caul_0691 142 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 167645785 Nonpathogen - hypothetical protein Caul_1821 1 None None None 167648703 Common - protein of unknown function DUF477 Caul_4748 37 COG3762 COG3762, Predicted membrane protein Function unknown 167644752 Common - Holliday junction DNA helicase RuvB Caul_0786 239 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 167647384 Nonpathogen - hypothetical protein Caul_3422 1 None None None 167647742 Common - transcriptional regulator, GntR family Caul_3780 110 COG1802 GntR, Transcriptional regulators Transcription 167645975 Nonpathogen - hypothetical protein Caul_2012 3 None None None 167648233 Common - excinuclease ABC, C subunit Caul_4277 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 167648969 Common - Maf family protein Caul_5014 179 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 167646070 Common - TonB-like protein Caul_2107 4 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 167645352 Common - methyl-accepting chemotaxis sensory transducer Caul_1387 154 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 167646689 Common - anti-FecI sigma factor, FecR Caul_2727 46 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 167646898 Common - transposase IS116/IS110/IS902 family protein Caul_2936 63 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646276 Nonpathogen - protein of unknown function, Spy-related Caul_2314 7 None None None 167646205 Common - TonB-dependent receptor Caul_2243 102 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 167644531 Common - TonB-dependent receptor Caul_0563 121 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647939 Common - isochorismatase hydrolase Caul_3979 111 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 167648377 Common - hypothetical protein Caul_4422 7 None None None 167648608 Common - polyhydroxyalkanoate depolymerase, intracellular Caul_4653 44 COG4553 DepA, Poly-beta-hydroxyalkanoate depolymerase Lipid metabolism 167647262 Nonpathogen - response regulator receiver protein Caul_3300 5 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 167648237 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Caul_4281 185 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 167647008 Common - ATP-cone domain protein Caul_3046 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 167644631 Nonpathogen - hypothetical protein Caul_0663 1 None None None 167644650 Common - transcriptional regulator, ArsR family Caul_0682 70 COG0640 ArsR, Predicted transcriptional regulators Transcription 167646122 Common - PDZ/DHR/GLGF domain protein Caul_2159 181 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 167648400 Common - oxidoreductase FAD/NAD(P)-binding domain protein Caul_4445 95 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 167647995 Nonpathogen - Mannosyl-oligosaccharide 1,2-alpha-mannosidase Caul_4035 2 COG3533 COG3533, Uncharacterized protein conserved in bacteria Function unknown 167647811 Common - protocatechuate 3,4-dioxygenase, beta subunit Caul_3850 51 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 167647505 Common - O-antigen polymerase Caul_3543 5 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 167647023 Common - OmpA/MotB domain protein Caul_3061 76 COG1360 MotB, Flagellar motor protein Cell motility and secretion 167647885 Common - hypothetical protein Caul_3925 17 None None None 167646893 Nonpathogen - hypothetical protein Caul_2931 1 None None None 167647340 Common - nucleoside 2-deoxyribosyltransferase Caul_3378 6 COG3613 COG3613, Nucleoside 2-deoxyribosyltransferase Nucleotide transport and metabolism 167645517 Common - hypothetical protein Caul_1552 25 COG4852 COG4852, Predicted membrane protein Function unknown 167648409 Common - ABC transporter periplasmic binding protein, urea carboxylase region Caul_4454 73 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 167644522 Common - Integrase catalytic region Caul_0554 75 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646858 Nonpathogen - hypothetical protein Caul_2896 9 None None None 167644657 Common - TfoX domain protein Caul_0689 24 COG3070 TfoX, Regulator of competence-specific genes Transcription 167648024 Common - GTP cyclohydrolase I Caul_4064 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 167647969 Common - hypothetical protein Caul_4009 12 None None None 167646978 Common - aminotransferase class I and II Caul_3016 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 167644722 Common - hypothetical protein Caul_0756 29 None None None 167646869 Common - peptidase M48 Ste24p Caul_2907 62 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 167648960 Common - putative signal-transduction protein with CBS domains Caul_5005 176 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 167648266 Common - nicotinate-nucleotide pyrophosphorylase Caul_4311 204 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 167648555 Common - major facilitator superfamily MFS_1 Caul_4600 150 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 167648336 Nonpathogen - hypothetical protein Caul_4381 1 None None None 167648896 Common - glycosyl transferase group 1 Caul_4941 18 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 167646801 Common - glycosyl transferase group 1 Caul_2839 152 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 167644441 Nonpathogen - hypothetical protein Caul_0472 1 None None None 167646478 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Caul_2516 105 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 167645119 Common - hypothetical protein Caul_1154 18 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 167645221 Nonpathogen - hypothetical protein Caul_1256 1 None None None 167647769 Common - ParB domain protein nuclease Caul_3808 39 COG1475 Spo0J, Predicted transcriptional regulators Transcription 167647684 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase Caul_3722 209 COG0281 SfcA, Malic enzyme Energy production and conversion 167647828 Common - respiratory nitrate reductase, gamma subunit Caul_3867 58 COG2181 NarI, Nitrate reductase gamma subunit Energy production and conversion 167645287 Nonpathogen - hypothetical protein Caul_1322 1 None None None 167647895 Common - Rieske (2Fe-2S) domain protein Caul_3935 89 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 167647309 Common - phosphoserine phosphatase SerB Caul_3347 151 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 167645918 Common - acetate kinase Caul_1954 161 COG0282 ackA, Acetate kinase Energy production and conversion 167645080 Common - Activator of Hsp90 ATPase 1 family protein Caul_1115 18 COG3832 COG3832, Uncharacterized conserved protein Function unknown 167644300 Nonpathogen - Conjugal transfer TraD family protein Caul_0328 10 None None None 167647117 Common - cyclic nucleotide-binding protein Caul_3155 114 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 167647542 Common - Biopolymer transport protein ExbD/TolR Caul_3580 134 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 167646572 Common - RNA chaperone Hfq Caul_2610 127 COG1923 Hfq, Uncharacterized host factor I protein General function prediction only 167646190 Common - integrase family protein Caul_2228 210 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 167648900 Common - Glutathione S-transferase domain Caul_4945 69 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167644877 Nonpathogen - protein of unknown function DUF465 Caul_0911 1 COG5570 COG5570, Uncharacterized small protein Function unknown 167644881 Common - protein of unknown function DUF1465 Caul_0915 19 COG5317 COG5317, Uncharacterized protein conserved in bacteria Function unknown 167644228 Common - Acid phosphatase Caul_0256 23 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 167648150 Common - pilus assembly protein CpaE Caul_4191 109 COG4963 CpaE, Flp pilus assembly protein, ATPase CpaE Intracellular trafficking and secretion 167648851 Common - putative mRNA 3-end processing factor Caul_4896 69 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 167647651 Common - flagellar P-ring protein Caul_3689 105 COG1706 FlgI, Flagellar basal-body P-ring protein Cell motility and secretion 167646432 Common - beta-lactamase domain protein Caul_2470 194 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 167647528 Common - Mammalian cell entry related domain protein Caul_3566 84 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 167648832 Nonpathogen - activator of HSP90 ATPase 1 family protein Caul_4877 5 COG3832 COG3832, Uncharacterized conserved protein Function unknown 167647324 Common - beta-lactamase Caul_3362 118 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 167647427 Nonpathogen - hypothetical protein Caul_3465 4 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 167644848 Common - oligoendopeptidase, pepF/M3 family Caul_0882 86 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 167645806 Common - tryptophan halogenase Caul_1842 16 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 167646851 Common - flagellar FlbT family protein Caul_2889 23 COG5443 FlbT, Flagellar biosynthesis regulator FlbT Cell motility and secretion 167646643 Common - alanine racemase domain protein Caul_2681 68 COG3616 COG3616, Predicted amino acid aldolase or racemase Amino acid transport and metabolism 167647413 Common - peptidase S15 Caul_3451 61 COG2936 COG2936, Predicted acyl esterases General function prediction only 167645706 Nonpathogen - hypothetical protein Caul_1742 6 None None None 167648283 Common - D-lactate dehydrogenase (cytochrome) Caul_4328 188 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 167644921 Nonpathogen - hypothetical protein Caul_0956 1 None None None 167645808 Common - glycoside hydrolase family 10 Caul_1844 29 COG3693 XynA, Beta-1,4-xylanase Carbohydrate transport and metabolism 167646363 Common - transcriptional regulator, LacI family Caul_2401 126 COG1609 PurR, Transcriptional regulators Transcription 167646634 Common - hypothetical protein Caul_2672 19 COG5470 COG5470, Uncharacterized conserved protein Function unknown 167644147 Common - protein of unknown function UPF0102 Caul_0175 38 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 167645135 Common - Entericidin EcnAB Caul_1170 3 None None None 167647204 Common - transcriptional regulator, LysR family Caul_3242 182 COG0583 LysR, Transcriptional regulator Transcription 167647923 Common - response regulator receiver protein Caul_3963 224 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 167647782 Common - putative conjugal transfer protein precursor Caul_3821 30 COG4959 TraF, Type IV secretory pathway, protease TraF Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 167646765 Common - uridylate kinase Caul_2803 243 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 167647627 Common - Endonuclease/exonuclease/phosphatase Caul_3665 50 COG2374 COG2374, Predicted extracellular nuclease General function prediction only 167646019 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Caul_2056 125 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 167644870 Common - phosphoribosylaminoimidazole carboxylase, catalytic subunit Caul_0904 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 167648918 Common - heat shock protein Hsp20 Caul_4963 67 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 167645921 Common - protein of unknown function UPF0118 Caul_1957 58 COG0628 PerM, Predicted permease General function prediction only 167646249 Common - sodium/calcium exchanger membrane region Caul_2287 7 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 167645649 Common - 8-amino-7-oxononanoate synthase Caul_1685 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 167647409 Common - Rubredoxin-type Fe(Cys)4 protein Caul_3447 121 COG1773 COG1773, Rubredoxin Energy production and conversion 167645890 Common - transcriptional regulator, TetR family Caul_1926 20 COG1309 AcrR, Transcriptional regulator Transcription 167646563 Nonpathogen - hypothetical protein Caul_2601 8 COG4129 COG4129, Predicted membrane protein Function unknown 167644291 Common - ATPase BadF/BadG/BcrA/BcrD type Caul_0319 59 COG2971 COG2971, Predicted N-acetylglucosamine kinase Carbohydrate transport and metabolism 167648645 Common - protein of unknown function DUF1353 Caul_4690 5 None None None 167647645 Nonpathogen - hypothetical protein Caul_3683 2 None None None 167647076 Common - stationary-phase survival protein SurE Caul_3114 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 167646254 Common - protein of unknown function DUF190 Caul_2292 24 COG1993 COG1993, Uncharacterized conserved protein Function unknown 167645841 Common - MaoC domain protein dehydratase Caul_1877 91 COG2030 MaoC, Acyl dehydratase Lipid metabolism 167645318 Nonpathogen - hypothetical protein Caul_1353 6 None None None 167646347 Common - transcriptional regulator, LysR family Caul_2385 161 COG0583 LysR, Transcriptional regulator Transcription 167644462 Common - transcriptional regulator, TetR family Caul_0493 83 COG1309 AcrR, Transcriptional regulator Transcription 167646557 Common - iron-sulfur cluster assembly accessory protein Caul_2595 162 COG0316 IscA, Uncharacterized conserved protein Function unknown 167646077 Common - hypothetical protein Caul_2114 19 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 167647732 Common - amidohydrolase 2 Caul_3770 9 COG3618 COG3618, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 167645695 Nonpathogen - hypothetical protein Caul_1731 1 None None None 167644025 Nonpathogen - hypothetical protein Caul_0052 3 None None None 167646409 Common - Patatin Caul_2447 11 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 167645534 Common - PASTA domain containing protein Caul_1569 22 COG2815 COG2815, Uncharacterized protein conserved in bacteria Function unknown 167645983 Common - S1/P1 nuclease Caul_2020 20 None None None 167646458 Common - Tetratricopeptide TPR_2 repeat protein Caul_2496 36 COG4649 COG4649, Uncharacterized protein conserved in bacteria Function unknown 167647198 Common - Carboxylesterase type B Caul_3236 93 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 167647595 Nonpathogen - hypothetical protein Caul_3633 1 None None None 167644684 Common - cytidine deaminase Caul_0716 114 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 167647827 Common - nitrate reductase molybdenum cofactor assembly chaperone Caul_3866 52 COG2180 NarJ, Nitrate reductase delta subunit Energy production and conversion 167644320 Common - Alkaline phosphatase Caul_0348 56 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 167648127 Common - hypothetical protein Caul_4168 7 None None None 167646656 Common - two component transcriptional regulator, winged helix family Caul_2694 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167644065 Common - signal transduction histidine kinase Caul_0092 102 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 167644895 Common - ABC transporter related Caul_0929 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 167647263 Common - CheA signal transduction histidine kinase Caul_3301 149 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 167646732 Common - rotamase family protein Caul_2770 107 None None None 167644623 Common - peptidase M28 Caul_0655 36 COG2234 Iap, Predicted aminopeptidases General function prediction only 167646158 Common - sulfate ABC transporter, ATPase subunit Caul_2195 249 COG1118 CysA, ABC-type sulfate/molybdate transport systems, ATPase component Inorganic ion transport and metabolism 167644617 Common - transcriptional regulator, LysR family Caul_0649 158 COG0583 LysR, Transcriptional regulator Transcription 167648502 Common - phosphate uptake regulator, PhoU Caul_4547 196 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 167648659 Common - AMP nucleosidase Caul_4704 54 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 167648991 Common - two component transcriptional regulator, winged helix family Caul_5036 209 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167644849 Common - ABC-1 domain protein Caul_0883 166 COG0661 AarF, Predicted unusual protein kinase General function prediction only 167644936 Common - transcriptional regulator, DeoR family Caul_0971 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 167645865 Common - hypothetical protein Caul_1901 3 None None None 167647104 Common - protein of unknown function DUF482 Caul_3142 82 COG3146 COG3146, Uncharacterized protein conserved in bacteria Function unknown 167644825 Common - secretion protein HlyD family protein Caul_0859 130 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 167644855 Common - glycosyl transferase family 9 Caul_0889 73 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 167646242 Common - hypothetical protein Caul_2280 4 None None None 167648087 Common - ribosomal protein L28 Caul_4128 119 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 167644053 Nonpathogen - hypothetical protein Caul_0080 1 COG4575 ElaB, Uncharacterized conserved protein Function unknown 167647818 Common - Hemerythrin HHE cation binding domain protein Caul_3857 45 COG2846 COG2846, Regulator of cell morphogenesis and NO signaling Cell division and chromosome partitioning 167647768 Common - conserved hypothetical membrane spanning protein Caul_3807 45 COG3593 COG3593, Predicted ATP-dependent endonuclease of the OLD family DNA replication, recombination, and repair 167648155 Nonpathogen - Flp/Fap pilin component Caul_4196 1 COG3847 Flp, Flp pilus assembly protein, pilin Flp Intracellular trafficking and secretion 167644995 Common - hypothetical protein Caul_1030 2 None None None 167645945 Nonpathogen - helix-turn-helix domain protein Caul_1982 1 None None None 167646450 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Caul_2488 26 COG0546 Gph, Predicted phosphatases General function prediction only 167645499 Nonpathogen - hypothetical protein Caul_1534 4 None None None 167648215 Nonpathogen - hypothetical protein Caul_4259 1 None None None 167648655 Common - 3-oxoacid CoA-transferase, B subunit Caul_4700 93 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 167647549 Common - hypothetical protein Caul_3587 31 COG5328 COG5328, Uncharacterized protein conserved in bacteria Function unknown 167648428 Common - phenazine biosynthesis protein PhzF family Caul_4473 119 COG0384 COG0384, Predicted epimerase, PhzC/PhzF homolog General function prediction only 167648497 Common - tetraacyldisaccharide 4'-kinase Caul_4542 130 COG1663 LpxK, Tetraacyldisaccharide-1-P 4'-kinase Cell envelope biogenesis, outer membrane 167645601 Common - ribosomal protein S11 Caul_1637 248 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 167645116 Nonpathogen - hypothetical protein Caul_1151 9 None None None 167649005 Common - transcriptional regulator, AraC family Caul_5050 206 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 167643985 Common - tryptophanyl-tRNA synthetase Caul_0012 237 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 167646175 Common - TrkA-N domain protein Caul_2212 195 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 167648219 Common - DNA primase Caul_4263 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 167645642 Common - permease YjgP/YjgQ family protein Caul_1678 102 COG0795 COG0795, Predicted permeases General function prediction only 167644428 Common - flavodoxin/nitric oxide synthase Caul_0456 61 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 167644421 Common - transcriptional regulator, LysR family Caul_0449 155 COG0583 LysR, Transcriptional regulator Transcription 167647518 Common - PilT protein domain protein Caul_3556 38 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 167644581 Common - CheW protein Caul_0613 121 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 167644745 Nonpathogen - hypothetical protein Caul_0779 1 None None None 167647275 Common - hypothetical protein Caul_3313 5 None None None 167648812 Common - O-methyltransferase family 3 Caul_4857 80 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 167647580 Common - Aldose 1-epimerase Caul_3618 90 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 167648847 Common - histone deacetylase superfamily Caul_4892 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 167645835 Common - Transketolase central region Caul_1871 186 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 167646269 Common - copper-translocating P-type ATPase Caul_2307 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 167646385 Common - two component transcriptional regulator, winged helix family Caul_2423 205 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167647773 Common - transcriptional regulator, XRE family Caul_3812 45 COG1476 COG1476, Predicted transcriptional regulators Transcription 167645159 Common - major facilitator superfamily MFS_1 Caul_1194 224 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167646330 Common - TonB-dependent receptor Caul_2368 119 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647191 Common - Prephenate dehydrogenase Caul_3229 169 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 167648907 Common - undecaprenol kinase Caul_4952 199 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 167647014 Common - Enoyl-CoA hydratase/isomerase Caul_3052 159 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 167648199 Common - potassium-transporting ATPase, A subunit Caul_4242 96 COG2060 KdpA, K+-transporting ATPase, A chain Inorganic ion transport and metabolism 167646043 Common - Methyltransferase type 12 Caul_2080 6 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 167644941 Common - Lysine exporter protein (LYSE/YGGA) Caul_0976 60 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 167646448 Common - transcriptional regulator, MarR family Caul_2486 24 COG1846 MarR, Transcriptional regulators Transcription 167645203 Common - multi-sensor signal transduction histidine kinase Caul_1238 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167646545 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Caul_2583 220 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 167646581 Common - transcription-repair coupling factor Caul_2619 218 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 167644832 Common - tRNA U-34 5-methylaminomethyl-2-thiouridine biosynthesis protein MnmC Caul_0866 66 COG4121 COG4121, Uncharacterized conserved protein Function unknown 167646716 Common - DoxX family protein Caul_2754 49 COG2259 COG2259, Predicted membrane protein Function unknown 167644090 Common - metalloendopeptidase, glycoprotease family Caul_0117 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 167645483 Common - Holliday junction resolvase YqgF Caul_1518 154 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 167644369 Common - protein of unknown function DUF262 Caul_0397 40 COG1479 COG1479, Uncharacterized conserved protein Function unknown 167644006 Common - translation initiation factor IF-2 Caul_0033 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 167645152 Nonpathogen - hypothetical protein Caul_1187 1 None None None 167647412 Common - X-Pro dipeptidyl-peptidase domain protein Caul_3450 58 COG2936 COG2936, Predicted acyl esterases General function prediction only 167646588 Common - Domain of unknown function DUF1801 Caul_2626 28 COG5649 COG5649, Uncharacterized conserved protein Function unknown 167645066 Common - putative transposase Caul_1101 18 None None None 167645143 Common - DNA polymerase beta domain protein region Caul_1178 27 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 167648006 Common - Glutathione S-transferase domain Caul_4046 94 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167648601 Nonpathogen - hypothetical protein Caul_4646 1 None None None 167646521 Common - pentapeptide repeat protein Caul_2559 51 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 167647355 Common - Antibiotic biosynthesis monooxygenase Caul_3393 14 COG1359 COG1359, Uncharacterized conserved protein Function unknown 167648463 Common - hypothetical protein Caul_4508 13 COG4709 COG4709, Predicted membrane protein Function unknown 167648668 Common - glutamate 5-kinase Caul_4713 190 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 167648638 Common - hypothetical protein Caul_4683 13 None None None 167645563 Nonpathogen - hypothetical protein Caul_1599 1 None None None 167648575 Common - drug resistance transporter, EmrB/QacA subfamily Caul_4620 135 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167648691 Nonpathogen - hypothetical protein Caul_4736 1 None None None 167648801 Nonpathogen - hypothetical protein Caul_4846 1 None None None 167644253 Common - MCP methyltransferase, CheR-type Caul_0281 150 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 167648100 Nonpathogen - hypothetical protein Caul_4141 1 None None None 167645060 Common - GCN5-related N-acetyltransferase Caul_1095 51 COG0456 RimI, Acetyltransferases General function prediction only 167645368 Common - hypothetical protein Caul_1403 16 COG3789 COG3789, Uncharacterized protein conserved in bacteria Function unknown 167648131 Common - IstB domain protein ATP-binding protein Caul_4172 101 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 167646023 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_2060 85 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167648834 Common - alkyl hydroperoxide reductase, F subunit Caul_4879 248 COG3634 AhpF, Alkyl hydroperoxide reductase, large subunit Posttranslational modification, protein turnover, chaperones 167647300 Common - protein of unknown function DUF214 Caul_3338 21 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 167646261 Common - acyltransferase 3 Caul_2299 75 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 167646182 Common - histone family protein DNA-binding protein Caul_2219 202 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 167645811 Common - Carboxylesterase type B Caul_1847 53 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 167644604 Nonpathogen - cyd operon protein YbgT Caul_0636 1 COG4890 COG4890, Predicted outer membrane lipoprotein Function unknown 167644660 Common - GCN5-related N-acetyltransferase Caul_0692 36 COG3153 COG3153, Predicted acetyltransferase General function prediction only 167647555 Nonpathogen - hypothetical protein Caul_3593 2 None None None 167647955 Common - transcriptional regulator, LacI family Caul_3995 126 COG1609 PurR, Transcriptional regulators Transcription 167646135 Common - protein of unknown function DUF486 Caul_2172 53 COG3169 COG3169, Uncharacterized protein conserved in bacteria Function unknown 167646402 Common - cytochrome c oxidase, cbb3-type, subunit III Caul_2440 75 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 167647368 Nonpathogen - hypothetical protein Caul_3406 1 None None None 167646465 Nonpathogen - Colicin V production protein Caul_2503 3 COG1286 CvpA, Uncharacterized membrane protein, required for colicin V production General function prediction only 167644768 Common - ribosomal protein S7 Caul_0802 249 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 167646039 Common - methyltransferase FkbM family Caul_2076 36 COG2520 COG2520, Predicted methyltransferase General function prediction only 167648797 Common - NUDIX hydrolase Caul_4842 103 None None None 167646537 Common - peptide chain release factor 2 Caul_2575 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 167646568 Common - nitrogen metabolism transcriptional regulator, NtrC, Fis Family Caul_2606 217 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 167647463 Nonpathogen - hypothetical protein Caul_3501 1 None None None 167645247 Common - aldo/keto reductase Caul_1282 185 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 167647664 Common - gid protein Caul_3702 167 COG1206 Gid, NAD(FAD)-utilizing enzyme possibly involved in translation Translation, ribosomal structure and biogenesis 167645877 Common - Limonene-12-epoxide hydrolase Caul_1913 8 COG4308 LimA, Limonene-1,2-epoxide hydrolase Secondary metabolites biosynthesis, transport, and catabolism 167648421 Common - hypothetical protein Caul_4466 9 None None None 167646725 Nonpathogen - peptidase A2A retrovirus catalytic Caul_2763 7 COG3577 COG3577, Predicted aspartyl protease General function prediction only 167647947 Common - response regulator receiver protein Caul_3987 179 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167646666 Common - pseudouridine synthase Caul_2704 203 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 167645092 Common - protein of unknown function DUF1611 Caul_1127 35 COG3367 COG3367, Uncharacterized conserved protein Function unknown 167646353 Common - transcriptional regulator, winged helix family Caul_2391 49 COG3903 COG3903, Predicted ATPase General function prediction only 167648819 Common - glutathione-dependent formaldehyde-activating GFA Caul_4864 63 COG3791 COG3791, Uncharacterized conserved protein Function unknown 167643980 Common - putative DNA-binding protein Caul_0007 62 COG3943 COG3943, Virulence protein General function prediction only 167646744 Common - transcriptional repressor, LexA family Caul_2782 172 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 167646824 Common - major facilitator superfamily MFS_1 Caul_2862 180 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167648758 Nonpathogen - hypothetical protein Caul_4803 1 None None None 167648082 Common - VapB family protein Caul_4123 6 COG4456 VagC, Virulence-associated protein and related proteins Function unknown 167645903 Common - short-chain dehydrogenase/reductase SDR Caul_1939 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167645738 Common - hypothetical protein Caul_1774 15 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167644163 Common - histidine kinase Caul_0191 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167647258 Common - Transglycosylase-associated protein Caul_3296 5 COG2261 COG2261, Predicted membrane protein Function unknown 167645559 Common - ribosomal L11 methyltransferase Caul_1594 119 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 167645821 Common - outer membrane autotransporter barrel domain protein Caul_1857 63 COG4625 COG4625, Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain Function unknown 167647436 Common - hypothetical protein Caul_3474 16 None None None 167647378 Common - signal peptidase I Caul_3416 198 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 167645610 Common - transcriptional regulator, ArsR family Caul_1646 44 COG0640 ArsR, Predicted transcriptional regulators Transcription 167646413 Nonpathogen - hypothetical protein Caul_2451 3 COG5622 COG5622, Protein required for attachment to host cells Cell motility and secretion 167648169 Common - UspA domain protein Caul_4210 48 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 167644913 Common - ubiquinone biosynthesis O-methyltransferase Caul_0947 160 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 167648546 Common - YbaK/prolyl-tRNA synthetase associated region Caul_4591 29 COG3760 COG3760, Uncharacterized conserved protein Function unknown 167648773 Nonpathogen - hypothetical protein Caul_4818 1 None None None 167645686 Common - Uracil-DNA glycosylase superfamily Caul_1722 80 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 167647494 Common - alpha/beta hydrolase fold Caul_3532 105 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167649021 Common - drug resistance transporter, EmrB/QacA subfamily Caul_5066 201 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167648260 Common - cell wall hydrolase SleB Caul_4305 40 COG3773 SleB, Cell wall hydrolyses involved in spore germination Cell envelope biogenesis, outer membrane 167647937 Nonpathogen - outer membrane protein Caul_3977 1 None None None 167648626 Common - hypothetical protein Caul_4671 13 COG1476 COG1476, Predicted transcriptional regulators Transcription 167646096 Common - glycoside hydrolase family 2 sugar binding Caul_2133 54 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 167645829 Common - TonB-dependent receptor Caul_1865 20 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647304 Common - membrane protein involved in aromatic hydrocarbon degradation Caul_3342 79 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 167646500 Common - Nucleoside-diphosphate kinase Caul_2538 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 167648344 Common - arginyl-tRNA synthetase Caul_4389 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 167644340 Common - aldo/keto reductase Caul_0368 182 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 167647907 Common - peptidase C26 Caul_3947 111 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 167644456 Common - hypothetical protein Caul_0487 15 None None None 167645194 Common - ABC-2 type transporter Caul_1229 142 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 167647979 Common - prevent-host-death family protein Caul_4019 13 COG4118 Phd, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 167647331 Common - Phytanoyl-CoA dioxygenase Caul_3369 8 None None None 167646845 Nonpathogen - GCN5-related N-acetyltransferase Caul_2883 12 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 167647251 Common - TonB-dependent receptor Caul_3289 74 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 167645001 Common - protein of unknown function DUF1272 Caul_1036 24 COG3813 COG3813, Uncharacterized protein conserved in bacteria Function unknown 167645405 Common - 6-phosphogluconate dehydratase Caul_1440 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 167647033 Common - Class I peptide chain release factor Caul_3071 108 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 167646909 Common - molydopterin dinucleotide-binding region Caul_2947 173 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 167646210 Common - hypothetical protein Caul_2248 24 None None None 167646356 Nonpathogen - hypothetical protein Caul_2394 1 None None None 167648826 Common - hypothetical protein Caul_4871 6 COG5653 COG5653, Protein involved in cellulose biosynthesis (CelD) Cell envelope biogenesis, outer membrane 167644553 Common - major facilitator superfamily MFS_1 Caul_0585 180 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167648736 Common - Heparinase II/III family protein Caul_4781 33 COG5360 COG5360, Uncharacterized protein conserved in bacteria Function unknown 167648962 Common - cell divisionFtsK/SpoIIIE Caul_5007 197 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 167647472 Common - beta-lactamase Caul_3510 119 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 167648876 Common - nucleotide sugar dehydrogenase Caul_4921 201 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 167647807 Common - 4-hydroxybenzoate 3-monooxygenase Caul_3846 75 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 167646425 Nonpathogen - hypothetical protein Caul_2463 1 None None None 167647712 Nonpathogen - prevent-host-death family protein Caul_3750 7 None None None 167644863 Nonpathogen - hypothetical protein Caul_0897 1 None None None 167648435 Common - protein of unknown function DUF328 Caul_4480 77 COG3022 COG3022, Uncharacterized protein conserved in bacteria Function unknown 167648880 Nonpathogen - Endonuclease/exonuclease/phosphatase Caul_4925 1 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 167647025 Common - short-chain dehydrogenase/reductase SDR Caul_3063 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167645053 Common - efflux transporter, RND family, MFP subunit Caul_1088 153 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 167647231 Common - uroporphyrin-III C-methyltransferase Caul_3269 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 167644792 Common - glycosyl transferase group 1 Caul_0826 220 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 167645157 Common - ribosomal protein L35 Caul_1192 100 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 167647719 Common - short-chain dehydrogenase/reductase SDR Caul_3757 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167647980 Common - sugar transporter Caul_4020 163 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167648768 Common - type I secretion membrane fusion protein, HlyD family Caul_4813 133 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 167644406 Common - Alcohol dehydrogenase zinc-binding domain protein Caul_0434 181 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 167644976 Common - protein of unknown function DUF1153 Caul_1011 27 None None None 167645740 Nonpathogen - PilT protein domain protein Caul_1776 7 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 167644820 Common - transcriptional regulator, BadM/Rrf2 family Caul_0854 85 COG1959 COG1959, Predicted transcriptional regulator Transcription 167647291 Common - hypothetical protein Caul_3329 46 COG2267 PldB, Lysophospholipase Lipid metabolism 167646128 Common - Lytic transglycosylase catalytic Caul_2165 163 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 167648437 Common - Patatin Caul_4482 56 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 167645321 Nonpathogen - hypothetical protein Caul_1356 12 COG5330 COG5330, Uncharacterized protein conserved in bacteria Function unknown 167648244 Nonpathogen - hypothetical protein Caul_4289 4 None None None 167644136 Nonpathogen - hypothetical protein Caul_0164 1 None None None 167644953 Common - hypothetical protein Caul_0988 31 COG5373 COG5373, Predicted membrane protein Function unknown 167645780 Nonpathogen - hypothetical protein Caul_1816 7 None None None 167644341 Common - protein of unknown function DUF344 Caul_0369 127 COG2326 COG2326, Uncharacterized conserved protein Function unknown 167648584 Common - integral membrane sensor signal transduction histidine kinase Caul_4629 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167647127 Common - ThiJ/PfpI domain protein Caul_3165 16 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 167648251 Nonpathogen - hypothetical protein Caul_4296 1 None None None 167645325 Common - TonB-dependent receptor Caul_1360 85 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647600 Common - chromate transporter, chromate ion transporter (CHR) family Caul_3638 108 COG2059 ChrA, Chromate transport protein ChrA Inorganic ion transport and metabolism 167646703 Common - cobalamin biosynthesis protein CobD Caul_2741 146 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 167647299 Nonpathogen - Calcium-binding EF-hand-containing protein Caul_3337 1 None None None 167644486 Common - major facilitator superfamily MFS_1 Caul_0517 71 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 167645011 Common - Electron transfer flavoprotein alpha subunit Caul_1046 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 167645974 Common - ParB domain protein nuclease Caul_2011 69 COG1475 Spo0J, Predicted transcriptional regulators Transcription 167644066 Nonpathogen - Entericidin EcnAB Caul_0093 1 COG5510 COG5510, Predicted small secreted protein Function unknown 167645385 Common - major facilitator superfamily MFS_1 Caul_1420 48 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 167647613 Common - fumarylacetoacetate (FAA) hydrolase Caul_3651 59 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 167647449 Nonpathogen - hypothetical protein Caul_3487 1 None None None 167644334 Nonpathogen - translation initiation factor 2, gamma subunit, GTPase Caul_0362 10 None None None 167645777 Nonpathogen - hypothetical protein Caul_1813 11 COG3628 COG3628, Phage baseplate assembly protein W General function prediction only 167647585 Common - transcriptional regulator, LacI family Caul_3623 126 COG1609 PurR, Transcriptional regulators Transcription 167647328 Common - protein of unknown function DUF1697 Caul_3366 30 COG3797 COG3797, Uncharacterized protein conserved in bacteria Function unknown 167647665 Common - MscS Mechanosensitive ion channel Caul_3703 51 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 167645161 Common - translation initiation factor IF-3 Caul_1196 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 167646940 Common - protein of unknown function DUF214 Caul_2978 156 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 167647753 Common - sugar fermentation stimulation protein Caul_3792 103 COG1489 SfsA, DNA-binding protein, stimulates sugar fermentation General function prediction only 167645770 Common - histone family protein DNA-binding protein Caul_1806 200 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 167644508 Common - transcriptional regulator, TetR family Caul_0539 32 COG1309 AcrR, Transcriptional regulator Transcription 167644088 Common - YCII-related Caul_0115 34 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 167645892 Nonpathogen - hypothetical protein Caul_1928 1 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 167647706 Common - glucose-methanol-choline oxidoreductase Caul_3744 90 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 167647158 Common - DedA family protein Caul_3196 53 COG1238 COG1238, Predicted membrane protein Function unknown 167648674 Common - uncharacterized phage-associated protein-like protein Caul_4719 21 COG3600 GepA, Uncharacterized phage-associated protein Function unknown 167647513 Common - Helix-turn-helix type 11 domain protein Caul_3551 77 COG2378 COG2378, Predicted transcriptional regulator Transcription 167647597 Nonpathogen - hypothetical protein Caul_3635 1 None None None 167644282 Common - hypothetical protein Caul_0310 25 COG4222 COG4222, Uncharacterized protein conserved in bacteria Function unknown 167646777 Common - Rhomboid family protein Caul_2815 76 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 167646506 Common - phosphoribosylglycinamide formyltransferase Caul_2544 221 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 167646962 Common - Carbamoyl-phosphate synthase L chain ATP-binding Caul_3000 235 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 167645316 Common - hypothetical protein Caul_1351 5 COG5653 COG5653, Protein involved in cellulose biosynthesis (CelD) Cell envelope biogenesis, outer membrane 167644213 Common - drug resistance transporter, EmrB/QacA subfamily Caul_0241 217 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167645455 Common - Rod shape-determining protein MreC Caul_1490 142 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 167644606 Common - protein of unknown function DUF437 Caul_0638 8 None None None 167648419 Common - Pyruvate carboxylase., Methylmalonyl-CoA carboxytransferase Caul_4464 231 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 167645536 Nonpathogen - hypothetical protein Caul_1571 1 None None None 167644700 Common - acetyl-CoA carboxylase, carboxyl transferase, alpha subunit Caul_0734 182 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 167648987 Nonpathogen - hypothetical protein Caul_5032 1 None None None 167645661 Common - GCN5-related N-acetyltransferase Caul_1697 27 COG3153 COG3153, Predicted acetyltransferase General function prediction only 167648269 Common - acyltransferase 3 Caul_4314 9 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 167647861 Common - gene transfer agent (GTA) orfg15, like protein Caul_3901 26 None None None 167644907 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Caul_0941 200 COG0388 COG0388, Predicted amidohydrolase General function prediction only 167645438 Nonpathogen - hypothetical protein Caul_1473 1 None None None 167649033 Common - Enoyl-CoA hydratase/isomerase Caul_5078 185 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 167645925 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_1961 93 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167645987 Common - DNA-directed DNA polymerase Caul_2024 185 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 167644186 Common - Antibiotic biosynthesis monooxygenase Caul_0214 14 COG1359 COG1359, Uncharacterized conserved protein Function unknown 167645301 Common - transporter, hydrophobe/amphiphile efflux-1 (HAE1) family Caul_1336 180 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 167645285 Common - signal peptide peptidase SppA, 67K type Caul_1320 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 167646533 Common - peptidase M48 Ste24p Caul_2571 108 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 167647607 Nonpathogen - hypothetical protein Caul_3645 1 None None None 167645093 Common - Mandelate racemase/muconate lactonizing protein Caul_1128 115 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 167648636 Common - histidyl-tRNA synthetase Caul_4681 249 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 167645932 Common - anti-FecI sigma factor, FecR Caul_1968 47 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 167648759 Common - ExoV-like protein Caul_4804 13 None None None 167644827 Common - GTP-binding protein TypA Caul_0861 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 167647970 Common - acetyl-CoA acetyltransferase Caul_4010 167 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167647912 Common - glutamine synthetase catalytic region Caul_3952 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 167646173 Common - Ppx/GppA phosphatase Caul_2210 178 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 167646952 Common - FAD dependent oxidoreductase TIGR03364 Caul_2990 18 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 167644880 Nonpathogen - protein of unknown function DUF1192 Caul_0914 1 COG5509 COG5509, Uncharacterized small protein containing a coiled-coil domain Function unknown 167646163 Common - protein of unknown function DUF490 Caul_2200 77 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 167645747 Nonpathogen - hypothetical protein Caul_1783 1 None None None 167647102 Nonpathogen - hypothetical protein Caul_3140 2 None None None 167647516 Common - major facilitator superfamily MFS_1 Caul_3554 20 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 167645715 Nonpathogen - hypothetical protein Caul_1751 2 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 167645852 Common - transcriptional regulator, TetR family Caul_1888 18 COG1309 AcrR, Transcriptional regulator Transcription 167646625 Common - TonB-dependent receptor Caul_2663 112 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167644265 Common - Beta-N-acetylhexosaminidase Caul_0293 57 COG3525 Chb, N-acetyl-beta-hexosaminidase Carbohydrate transport and metabolism 167647853 Common - cytochrome c-type biogenesis protein CcmI Caul_3893 41 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 167645837 Common - dihydrolipoamide dehydrogenase Caul_1873 241 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 167646203 Common - asparagine synthase Caul_2241 6 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 167648194 Nonpathogen - putative transmembrane protein Caul_4237 1 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 167647151 Common - peptidase S58 DmpA Caul_3189 53 COG3191 DmpA, L-aminopeptidase/D-esterase Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167644206 Common - PilT protein domain protein Caul_0234 46 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 167644273 Common - Radical SAM domain protein Caul_0301 90 COG1964 COG1964, Predicted Fe-S oxidoreductases General function prediction only 167647141 Common - Tetratricopeptide TPR_2 repeat protein Caul_3179 47 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 167645886 Common - short-chain dehydrogenase/reductase SDR Caul_1922 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167647671 Common - protein of unknown function DUF989 Caul_3709 37 COG3748 COG3748, Predicted membrane protein Function unknown 167644248 Common - methyl-accepting chemotaxis sensory transducer Caul_0276 147 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 167646983 Nonpathogen - hypothetical protein Caul_3021 1 None None None 167644558 Common - beta-lactamase Caul_0590 131 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 167647069 Common - protein-export membrane protein SecF Caul_3107 209 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 167644075 Common - cytidylate kinase Caul_0102 204 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 167645209 Nonpathogen - hypothetical protein Caul_1244 1 None None None 167648717 Common - Hemolysin-type calcium-binding region Caul_4762 88 None None None 167646271 Nonpathogen - putative membrane protein of unknown function Caul_2309 1 None None None 167648094 Common - hypothetical protein Caul_4135 7 None None None 167646749 Common - citrate synthase I Caul_2787 194 COG0372 GltA, Citrate synthase Energy production and conversion 167648447 Nonpathogen - uncharacterized membrane-bound protein Caul_4492 1 COG4461 LprI, Uncharacterized protein conserved in bacteria, putative lipoprotein Function unknown 167648721 Common - transcriptional regulator, BadM/Rrf2 family Caul_4766 15 COG1959 COG1959, Predicted transcriptional regulator Transcription 167647041 Common - Transketolase central region Caul_3079 159 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 167648459 Common - protoheme IX farnesyltransferase Caul_4504 167 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 167644806 Common - Integrase catalytic region Caul_0840 146 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 167645372 Nonpathogen - CDP-alcohol phosphatidyltransferase Caul_1407 3 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 167646219 Common - hypothetical protein Caul_2257 23 None None None 167648720 Common - K potassium transporter Caul_4765 88 COG3158 Kup, K+ transporter Inorganic ion transport and metabolism 167645980 Common - hypothetical protein Caul_2017 27 COG3843 VirD2, Type IV secretory pathway, VirD2 components (relaxase) Intracellular trafficking and secretion 167644240 Common - transcriptional regulator, TetR family Caul_0268 12 COG3226 COG3226, Uncharacterized protein conserved in bacteria Function unknown 167644385 Common - acyl-CoA dehydrogenase domain protein Caul_0413 166 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167645341 Common - Substrate-binding region of ABC-type glycine betaine transport system Caul_1376 139 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 167645330 Nonpathogen - fliO protein Caul_1365 1 None None None 167646479 Common - malonyl CoA-acyl carrier protein transacylase Caul_2517 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 167645089 Common - transposase IS4 family protein Caul_1124 50 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 167647489 Common - isocitrate dehydrogenase, NADP-dependent Caul_3527 61 COG0538 Icd, Isocitrate dehydrogenases Energy production and conversion 167646060 Nonpathogen - hypothetical protein Caul_2097 1 None None None 167645554 Common - amino acid permease-associated region Caul_1589 170 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 167645733 Common - DNA ligase D Caul_1769 97 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 167644965 Nonpathogen - hypothetical protein Caul_1000 6 None None None 167647798 Common - hypothetical protein Caul_3837 23 COG5639 COG5639, Uncharacterized conserved small protein Function unknown 167648958 Common - MaoC domain protein dehydratase Caul_5003 62 COG2030 MaoC, Acyl dehydratase Lipid metabolism 167645952 Common - anti-FecI sigma factor, FecR Caul_1989 47 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 167648382 Common - Tol-Pal system beta propeller repeat protein TolB Caul_4427 160 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 167646947 Common - hypothetical protein Caul_2985 6 None None None 167646408 Common - hypothetical protein Caul_2446 35 COG3174 COG3174, Predicted membrane protein Function unknown 167645231 Nonpathogen - hypothetical protein Caul_1266 8 None None None 167646481 Common - acyl carrier protein Caul_2519 171 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167644378 Common - ParB domain protein nuclease Caul_0406 11 COG1475 Spo0J, Predicted transcriptional regulators Transcription 167647843 Common - peptidase M56 BlaR1 Caul_3883 15 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 167646926 Common - PAS/PAC sensor hybrid histidine kinase Caul_2964 209 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167647573 Common - hypothetical protein Caul_3611 6 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 167647905 Nonpathogen - hypothetical protein Caul_3945 1 COG3905 COG3905, Predicted transcriptional regulator Transcription 167647115 Common - Enoyl-CoA hydratase/isomerase Caul_3153 153 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 167648312 Common - dihydroorotase, multifunctional complex type Caul_4357 208 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 167644741 Common - 5-formyltetrahydrofolate cyclo-ligase Caul_0775 126 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 167647454 Nonpathogen - hypothetical protein Caul_3492 1 None None None 167646236 Common - Conjugal transfer protein Caul_2274 33 COG3701 TrbF, Type IV secretory pathway, TrbF components Intracellular trafficking and secretion 167646969 Common - FAD dependent oxidoreductase Caul_3007 21 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 167648889 Common - FAD dependent oxidoreductase Caul_4934 93 COG0579 COG0579, Predicted dehydrogenase General function prediction only 167644178 Common - hypothetical protein Caul_0206 5 None None None 167645589 Common - ribosomal protein L24 Caul_1625 214 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 167647879 Nonpathogen - hypothetical protein Caul_3919 4 COG3545 COG3545, Predicted esterase of the alpha/beta hydrolase fold General function prediction only 167647442 Nonpathogen - hypothetical protein Caul_3480 1 None None None 167645042 Common - transcriptional regulator, LysR family Caul_1077 178 COG0583 LysR, Transcriptional regulator Transcription 167647490 Nonpathogen - hypothetical protein Caul_3528 1 None None None 167647723 Common - transcriptional regulator, GntR family Caul_3761 96 COG1802 GntR, Transcriptional regulators Transcription 167647788 Common - P-type conjugative transfer ATPase TrbB Caul_3827 152 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 167648752 Common - FAD linked oxidase domain protein Caul_4797 46 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 167646608 Common - TonB-dependent receptor plug Caul_2646 85 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167644739 Common - plasmid stabilization system Caul_0773 10 COG3668 ParE, Plasmid stabilization system protein General function prediction only 167648611 Common - protein of unknown function DUF81 Caul_4656 47 COG0730 COG0730, Predicted permeases General function prediction only 167648791 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Caul_4836 240 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 167644773 Common - efflux transporter, RND family, MFP subunit Caul_0807 132 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 167643979 Common - chaperone protein DnaJ Caul_0006 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 167645461 Common - response regulator receiver protein Caul_1496 224 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 167645072 Common - transposase and inactivated derivatives-like protein Caul_1107 46 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646004 Nonpathogen - hypothetical protein Caul_2041 1 None None None 167644192 Common - hypothetical protein Caul_0220 50 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 167644875 Common - hypothetical protein Caul_0909 16 COG5589 COG5589, Uncharacterized conserved protein Function unknown 167647369 Common - homocysteine S-methyltransferase Caul_3407 165 COG0646 MetH, Methionine synthase I (cobalamin-dependent), methyltransferase domain Amino acid transport and metabolism 167644676 Common - GTP-binding protein YchF Caul_0708 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 167645137 Nonpathogen - hypothetical protein Caul_1172 5 None None None 167646376 Common - GntR domain protein Caul_2414 88 COG2186 FadR, Transcriptional regulators Transcription 167645700 Common - signal peptidase I Caul_1736 207 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 167645525 Common - tail sheath protein Caul_1560 49 COG3497 COG3497, Phage tail sheath protein FI General function prediction only 167644569 Common - protein of unknown function DUF262 Caul_0601 40 COG1479 COG1479, Uncharacterized conserved protein Function unknown 167645674 Common - fatty acid hydroxylase Caul_1710 14 None None None 167646195 Common - protein of unknown function DUF736 Caul_2233 18 COG5489 COG5489, Uncharacterized conserved protein Function unknown 167644482 Common - transcriptional regulator, AraC family Caul_0513 48 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 167647634 Common - UDP-N-acetylmuramyl-tripeptide synthetase Caul_3672 209 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 167644350 Common - hydroxyacylglutathione hydrolase Caul_0378 161 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 167644633 Common - Tetratricopeptide TPR_4 Caul_0665 10 COG4700 COG4700, Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats Function unknown 167645579 Common - ribosomal protein L4/L1e Caul_1615 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 167647934 Common - hypothetical protein Caul_3974 25 COG3662 COG3662, Uncharacterized protein conserved in bacteria Function unknown 167648515 Common - 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase Caul_4560 137 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 167645751 Common - protein tyrosine phosphatase Caul_1787 120 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 167644289 Common - D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit Caul_0317 33 COG4573 GatZ, Predicted tagatose 6-phosphate kinase Carbohydrate transport and metabolism 167648729 Common - orotidine 5'-phosphate decarboxylase Caul_4774 165 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 167643993 Common - cytochrome P450 Caul_0020 86 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 167644560 Common - 3-hydroxyacyl-CoA dehydrogenase NAD-binding Caul_0592 158 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 167647216 Common - flagellin domain protein Caul_3254 112 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 167645173 Common - KpsF/GutQ family protein Caul_1208 164 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 167647697 Common - transcriptional regulator, LysR family Caul_3735 94 COG0583 LysR, Transcriptional regulator Transcription 167644494 Common - Bile acid:sodium symporter Caul_0525 55 COG0385 COG0385, Predicted Na+-dependent transporter General function prediction only 167648806 Common - Nucleotidyl transferase Caul_4851 169 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 167645035 Nonpathogen - hypothetical protein Caul_1070 1 None None None 167646699 Common - cob(I)alamin adenosyltransferase Caul_2737 142 COG2109 BtuR, ATP:corrinoid adenosyltransferase Coenzyme metabolism 167648534 Common - transposase and inactivated derivatives-like protein Caul_4579 46 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646784 Common - NADH-ubiquinone oxidoreductase chain 4L Caul_2822 148 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 167646361 Common - transcriptional regulator, AraC family Caul_2399 125 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 167645411 Common - DSBA oxidoreductase Caul_1446 47 COG3917 NahD, 2-hydroxychromene-2-carboxylate isomerase Secondary metabolites biosynthesis, transport, and catabolism 167646937 Common - transcriptional regulator, Crp/Fnr family Caul_2975 105 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 167646857 Nonpathogen - hypothetical protein Caul_2895 1 None None None 167645213 Common - methylglyoxal synthase Caul_1248 83 COG1803 MgsA, Methylglyoxal synthase Carbohydrate transport and metabolism 167644160 Common - protein of unknown function DUF350 Caul_0188 26 COG3766 COG3766, Predicted membrane protein Function unknown 167644114 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_0141 46 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167645049 Common - transposase IS116/IS110/IS902 family protein Caul_1084 63 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 167645150 Nonpathogen - hypothetical protein Caul_1185 1 None None None 167647643 Common - protein of unknown function DUF6 transmembrane Caul_3681 84 COG2510 COG2510, Predicted membrane protein Function unknown 167645468 Nonpathogen - hypothetical protein Caul_1503 1 None None None 167647393 Common - PAS/PAC sensor signal transduction histidine kinase Caul_3431 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167646734 Nonpathogen - hypothetical protein Caul_2772 1 None None None 167645470 Common - DNA topoisomerase I Caul_1505 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 167644838 Common - Methyltransferase type 12 Caul_0872 40 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 167645403 Common - glucose-6-phosphate 1-dehydrogenase Caul_1438 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 167647196 Common - glycosyl transferase family 2 Caul_3234 59 COG2943 MdoH, Membrane glycosyltransferase Cell envelope biogenesis, outer membrane 167647132 Common - alpha/beta hydrolase fold Caul_3170 106 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167646010 Common - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Caul_2047 32 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 167648558 Common - transcriptional regulator, TetR family Caul_4603 65 COG1309 AcrR, Transcriptional regulator Transcription 167645188 Common - response regulator receiver protein Caul_1223 214 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 167644474 Common - major facilitator superfamily MFS_1 Caul_0505 40 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 167645917 Common - acetyl-CoA acetyltransferase Caul_1953 167 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167648352 Nonpathogen - hypothetical protein Caul_4397 1 None None None 167647172 Common - Redoxin domain protein Caul_3210 137 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 167648037 Common - cyclic nucleotide-binding protein Caul_4077 99 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167645259 Common - protein of unknown function DUF886 Caul_1294 41 COG3758 COG3758, Uncharacterized protein conserved in bacteria Function unknown 167646796 Common - NADH (or F420H2) dehydrogenase, subunit C Caul_2834 177 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 167644431 Nonpathogen - hypothetical protein Caul_0462 1 None None None 167646691 Nonpathogen - hypothetical protein Caul_2729 1 None None None 167646971 Common - protein of unknown function DUF192 Caul_3009 87 COG1430 COG1430, Uncharacterized conserved protein Function unknown 167648032 Common - aspartate-semialdehyde dehydrogenase Caul_4072 236 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 167646916 Common - molybdopterin oxidoreductase Caul_2954 189 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 167646758 Nonpathogen - outer membrane chaperone Skp (OmpH) Caul_2796 2 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 167648928 Nonpathogen - hypothetical protein Caul_4973 4 None None None 167644518 Common - monooxygenase FAD-binding Caul_0549 75 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 167648021 Common - GumN family protein Caul_4061 3 COG3735 COG3735, Uncharacterized protein conserved in bacteria Function unknown 167647338 Common - Polyprenyl synthetase Caul_3376 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 167645515 Nonpathogen - hypothetical protein Caul_1550 1 None None None 167645489 Nonpathogen - proteophosphoglycan 5 Caul_1524 1 None None None 167646325 Common - Sarcosine oxidase gamma subunit Caul_2363 14 COG4583 COG4583, Sarcosine oxidase gamma subunit Amino acid transport and metabolism 167644104 Common - acyl-CoA dehydrogenase domain protein Caul_0131 146 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167646142 Common - pyruvate, phosphate dikinase Caul_2179 234 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 167644048 Common - thioesterase superfamily protein Caul_0075 34 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 167648002 Common - diguanylate phosphodiesterase Caul_4042 129 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 167648016 Common - Excinuclease ABC C subunit domain protein Caul_4056 39 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 167648701 Common - LemA family protein Caul_4746 132 COG1704 LemA, Uncharacterized conserved protein Function unknown 167644454 Common - citrate/H+ symporter, CitMHS family Caul_0485 31 COG2851 CitM, H+/citrate symporter Energy production and conversion 167647874 Common - phage prohead protease, HK97 family Caul_3914 36 COG3740 COG3740, Phage head maturation protease General function prediction only 167644054 Nonpathogen - hypothetical protein Caul_0081 1 None None None 167644307 Common - DNA-binding protein Caul_0335 20 None None None 167644038 Common - transcriptional regulator, AsnC family Caul_0065 148 COG1522 Lrp, Transcriptional regulators Transcription 167648390 Common - ribosomal protein L11 Caul_4435 246 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 167647184 Common - aspartyl/asparaginyl beta-hydroxylase Caul_3222 9 None None None 167648486 Common - peptidase M14 carboxypeptidase A Caul_4531 22 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 167646130 Common - Electron-transferring-flavoprotein dehydrogenase Caul_2167 108 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 167646067 Common - Polypeptide-transport-associated domain protein ShlB-type Caul_2104 59 COG2831 FhaC, Hemolysin activation/secretion protein Intracellular trafficking and secretion 167644765 Nonpathogen - hypothetical protein Caul_0799 1 None None None 167645289 Common - helix-turn-helix domain protein Caul_1324 12 None None None 167646640 Common - putative MFS transporter Caul_2678 8 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 167647997 Common - PilT protein domain protein Caul_4037 34 COG3744 COG3744, Uncharacterized protein conserved in bacteria Function unknown 167645638 Nonpathogen - hypothetical protein Caul_1674 7 None None None 167647682 Common - xanthine dehydrogenase, small subunit Caul_3720 122 COG4630 XdhA, Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A Nucleotide transport and metabolism 167648606 Common - integral membrane sensor signal transduction histidine kinase Caul_4651 114 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167645961 Common - hypothetical protein Caul_1998 8 None None None 167644116 Common - TonB-dependent receptor plug Caul_0143 55 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167648894 Common - acetylornithine deacetylase (ArgE) Caul_4939 191 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 167648570 Common - Cyclopropane-fatty-acyl-phospholipid synthase Caul_4615 148 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 167647925 Common - DGPFAETKE family protein Caul_3965 27 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 167646867 Nonpathogen - hypothetical protein Caul_2905 8 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 167647865 Common - protein of unknown function DUF805 Caul_3905 10 COG3152 COG3152, Predicted membrane protein Function unknown 167648471 Common - polyhydroxyalkonate synthesis repressor, PhaR Caul_4516 64 COG5394 COG5394, Uncharacterized protein conserved in bacteria Function unknown 167647099 Nonpathogen - hypothetical protein Caul_3137 1 None None None 167646860 Common - metal dependent phosphohydrolase Caul_2898 33 COG1896 COG1896, Predicted hydrolases of HD superfamily General function prediction only 167648334 Common - H+transporting two-sector ATPase B/B' subunit Caul_4379 20 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 167645376 Common - protein of unknown function DUF72 Caul_1411 107 COG1801 COG1801, Uncharacterized conserved protein Function unknown 167646549 Common - aminotransferase class V Caul_2587 233 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 167645086 Common - peptidase S51 dipeptidase E Caul_1121 31 COG4242 CphB, Cyanophycinase and related exopeptidases Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism 167647791 Common - AAA ATPase Caul_3830 66 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 167648157 Common - TadE family protein Caul_4198 14 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 167644883 Common - ribosomal protein L31 Caul_0917 111 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 167647540 Common - transcriptional regulator, XRE family Caul_3578 41 COG1396 HipB, Predicted transcriptional regulators Transcription 167646808 Common - ATP-dependent Clp protease, ATP-binding subunit ClpX Caul_2846 234 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 167645267 Common - glycoside hydrolase family 29 (alpha-L-fucosidase) Caul_1302 27 COG3669 COG3669, Alpha-L-fucosidase Carbohydrate transport and metabolism 167645215 Common - hypothetical protein Caul_1250 84 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 167646805 Nonpathogen - hypothetical protein Caul_2843 1 None None None 167647085 Nonpathogen - Sporulation domain protein Caul_3123 6 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 167644753 Common - tol-pal system-associated acyl-CoA thioesterase Caul_0787 143 COG0824 FcbC, Predicted thioesterase General function prediction only 167647425 Common - peptidase M28 Caul_3463 64 COG2234 Iap, Predicted aminopeptidases General function prediction only 167645791 Nonpathogen - hypothetical protein Caul_1827 1 None None None 167648343 Common - hypothetical protein Caul_4388 4 None None None 167645542 Common - protein of unknown function DUF140 Caul_1577 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 167645265 Common - transcriptional regulator, histidine utilization repressor, GntR family Caul_1300 114 COG2188 PhnF, Transcriptional regulators Transcription 167648299 Common - short-chain dehydrogenase/reductase SDR Caul_4344 234 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167644850 Common - Pirin domain protein Caul_0884 148 COG1741 COG1741, Pirin-related protein General function prediction only 167647344 Nonpathogen - hypothetical protein Caul_3382 3 COG5455 COG5455, Predicted integral membrane protein Function unknown 167645363 Common - transcriptional regulator, AraC family Caul_1398 49 COG3449 COG3449, DNA gyrase inhibitor DNA replication, recombination, and repair 167647670 Common - hypothetical protein Caul_3708 44 COG3195 COG3195, Uncharacterized protein conserved in bacteria Function unknown 167646404 Common - FixH family protein Caul_2442 25 COG5456 COG5456, Predicted integral membrane protein linked to a cation pump Inorganic ion transport and metabolism 167647247 Nonpathogen - hypothetical protein Caul_3285 1 None None None 167644489 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Caul_0520 21 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 167646017 Common - ABC transporter related Caul_2054 249 COG5265 ATM1, ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components Posttranslational modification, protein turnover, chaperones 167648650 Common - Acid phosphatase Caul_4695 35 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 167644433 Common - helix-turn-helix domain protein Caul_0464 9 None None None 167646918 Common - nitrite reductase (NAD(P)H), large subunit Caul_2956 203 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 167645854 Common - fumarylacetoacetate (FAA) hydrolase Caul_1890 168 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 167646318 Nonpathogen - uncharacterized conserved secreted or membrane protein Caul_2356 9 None None None 167644363 Common - gamma-glutamyltransferase Caul_0391 147 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 167647748 Nonpathogen - hypothetical protein Caul_3786 2 None None None 167647653 Nonpathogen - flagellar basal-body protein FlbY Caul_3691 3 None None None 167645765 Common - Rieske (2Fe-2S) domain protein Caul_1801 88 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 167644871 Common - diguanylate cyclase Caul_0905 176 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 167647053 Common - transcriptional regulator, TetR family Caul_3091 117 COG1309 AcrR, Transcriptional regulator Transcription 167648956 Nonpathogen - hypothetical protein Caul_5001 1 None None None 167648317 Common - transcriptional regulator, XRE family Caul_4362 63 COG1476 COG1476, Predicted transcriptional regulators Transcription 167645839 Common - Propionyl-CoA carboxylase Caul_1875 144 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 167645679 Common - hypothetical protein Caul_1715 33 COG3245 CycB, Cytochrome c5 Energy production and conversion 167647784 Common - Lytic transglycosylase catalytic Caul_3823 158 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 167648581 Common - Phosphotransferase system, phosphocarrier protein HPr Caul_4626 143 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 167646434 Common - transcriptional regulator, ArsR family Caul_2472 100 COG0640 ArsR, Predicted transcriptional regulators Transcription 167645449 Nonpathogen - hypothetical protein Caul_1484 4 None None None 167646904 Nonpathogen - hypothetical protein Caul_2942 4 None None None 167644279 Common - Na+ dependent nucleoside transporter domain protein Caul_0307 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 167645730 Common - major facilitator superfamily MFS_1 Caul_1766 137 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 167649000 Common - Imidazoleglycerol-phosphate dehydratase Caul_5045 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 167644701 Common - prevent-host-death family protein Caul_0735 7 COG4118 Phd, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 167646518 Nonpathogen - hypothetical protein Caul_2556 1 None None None 167647390 Nonpathogen - hypothetical protein Caul_3428 4 None None None 167646247 Common - efflux transporter, RND family, MFP subunit Caul_2285 144 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 167646328 Common - sarcosine oxidase, beta subunit family Caul_2366 72 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 167648210 Common - hypothetical protein Caul_4254 7 None None None 167647201 Common - Propanoyl-CoA C-acyltransferase Caul_3239 122 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 167646594 Common - protein of unknown function DUF156 Caul_2632 105 COG1937 COG1937, Uncharacterized protein conserved in bacteria Function unknown 167644698 Common - OsmC family protein Caul_0732 41 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 167647860 Common - heat shock protein DnaJ domain protein Caul_3900 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 167645599 Common - adenylate kinase Caul_1635 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 167644943 Common - hypothetical protein Caul_0978 6 None None None 167647202 Common - protein of unknown function DUF35 Caul_3240 35 COG3425 PksG, 3-hydroxy-3-methylglutaryl CoA synthase Lipid metabolism 167646636 Common - sulfatase Caul_2674 80 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 167646767 Common - ribosomal protein S2 Caul_2805 217 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 167646368 Common - tryptophan halogenase Caul_2406 18 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 167644034 Common - protein of unknown function DUF182 Caul_0061 81 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 167647382 Common - Amidase Caul_3420 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 167648056 Common - putative activator of alkane oxidation Caul_4097 4 None None None 167648175 Common - protein of unknown function UPF0118 Caul_4216 163 COG0628 PerM, Predicted permease General function prediction only 167648375 Common - protein of unknown function DUF107 Caul_4420 22 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 167648756 Common - O-antigen polymerase Caul_4801 8 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 167646993 Common - transcriptional regulator, MerR family Caul_3031 90 COG0789 SoxR, Predicted transcriptional regulators Transcription 167648491 Common - hypothetical protein Caul_4536 24 None None None 167647803 Common - transcriptional regulator, LysR family Caul_3842 187 COG0583 LysR, Transcriptional regulator Transcription 167648239 Common - cold-shock DNA-binding domain protein Caul_4283 177 COG1278 CspC, Cold shock proteins Transcription 167644149 Common - TspO and MBR like protein Caul_0177 55 COG3476 COG3476, Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) Signal transduction mechanisms 167648275 Common - protein of unknown function DUF1003 Caul_4320 45 COG4420 COG4420, Predicted membrane protein Function unknown 167645344 Common - L-amino-acid oxidase Caul_1379 40 COG1231 COG1231, Monoamine oxidase Amino acid transport and metabolism 167648170 Common - efflux transporter, RND family, MFP subunit Caul_4211 71 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 167644987 Nonpathogen - FliJ protein Caul_1022 2 None None None 167645350 Common - integral membrane sensor hybrid histidine kinase Caul_1385 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167644619 Common - protein of unknown function DUF72 Caul_0651 78 COG1801 COG1801, Uncharacterized conserved protein Function unknown 167644980 Common - flagellar motor switch protein FliN Caul_1015 125 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 167647234 Common - protein of unknown function DUF124 Caul_3272 74 COG2013 COG2013, Uncharacterized conserved protein Function unknown 167644046 Common - ABC transporter related Caul_0073 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 167648281 Nonpathogen - Tetratricopeptide TPR_4 Caul_4326 1 None None None 167646684 Common - short-chain dehydrogenase/reductase SDR Caul_2722 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167644171 Common - WD-40 repeat protein Caul_0199 46 COG2319 COG2319, FOG: WD40 repeat General function prediction only 167645122 Common - transcriptional regulator, XRE family Caul_1157 19 COG1476 COG1476, Predicted transcriptional regulators Transcription 167648115 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Caul_4156 141 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 167647920 Common - methyl-accepting chemotaxis sensory transducer Caul_3960 25 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 167648254 Common - flagellin modification protein FlmD Caul_4299 25 COG3980 spsG, Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase Cell envelope biogenesis, outer membrane 167644711 Nonpathogen - hypothetical protein Caul_0745 1 None None None 167644226 Nonpathogen - hypothetical protein Caul_0254 7 COG0824 FcbC, Predicted thioesterase General function prediction only 167646870 Common - extracellular solute-binding protein family 3 Caul_2908 187 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 167646256 Common - outer membrane efflux protein Caul_2294 21 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 167647940 Common - Endoribonuclease L-PSP Caul_3980 183 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 167645647 Nonpathogen - diacylglycerol kinase catalytic region Caul_1683 15 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 167646462 Common - short-chain dehydrogenase/reductase SDR Caul_2500 229 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167647165 Nonpathogen - hypothetical protein Caul_3203 1 None None None 167648288 Common - Pirin domain protein Caul_4333 146 COG1741 COG1741, Pirin-related protein General function prediction only 167648596 Common - protein of unknown function DUF1211 Caul_4641 13 COG3548 COG3548, Predicted integral membrane protein Function unknown 167648450 Nonpathogen - hypothetical protein Caul_4495 1 None None None 167645240 Common - peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin Caul_1275 12 COG1876 VanY, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 167645104 Common - oxidoreductase FAD/NAD(P)-binding domain protein Caul_1139 116 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 167644635 Common - ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5 Caul_0667 184 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 167646882 Common - Cyclopropane-fatty-acyl-phospholipid synthase Caul_2920 135 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 167647620 Common - cell division protein FtsA Caul_3658 171 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 167646730 Common - signal transduction histidine kinase Caul_2768 84 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 167648380 Common - tol-pal system protein YbgF Caul_4425 59 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 167647730 Common - ABC transporter related Caul_3768 249 COG1135 AbcC, ABC-type metal ion transport system, ATPase component Inorganic ion transport and metabolism 167644459 Common - alpha/beta hydrolase fold Caul_0490 168 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167645178 Common - hypothetical protein Caul_1213 31 COG3528 COG3528, Uncharacterized protein conserved in bacteria Function unknown 167645453 Common - hypothetical protein Caul_1488 24 None None None 167646397 Common - methyl-accepting chemotaxis sensory transducer Caul_2435 141 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 167644836 Common - hypothetical protein Caul_0870 7 None None None 167644588 Common - PAS/PAC sensor hybrid histidine kinase Caul_0620 224 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167646083 Common - transcriptional regulator, LuxR family Caul_2120 57 COG2771 CsgD, DNA-binding HTH domain-containing proteins Transcription 167648621 Common - transcriptional regulator, TetR family Caul_4666 59 COG1309 AcrR, Transcriptional regulator Transcription 167648618 Common - ABC-2 type transporter Caul_4663 152 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 167648221 Common - RNA polymerase, sigma 70 subunit, RpoD Caul_4265 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 167645956 Nonpathogen - hypothetical protein Caul_1993 4 None None None 167648046 Common - major facilitator superfamily MFS_1 Caul_4087 30 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 167645193 Common - GcrA cell cycle regulator Caul_1228 33 COG5352 COG5352, Uncharacterized protein conserved in bacteria Function unknown 167647194 Nonpathogen - hypothetical protein Caul_3232 1 None None None 167646311 Common - cytochrome c family protein Caul_2349 20 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 167644316 Nonpathogen - hypothetical protein Caul_0344 1 None None None 167645015 Common - hypothetical protein Caul_1050 14 None None None 167648665 Common - glutathione S-transferase family protein Caul_4710 71 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167647547 Common - translation initiation factor IF-1 Caul_3585 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 167646771 Common - Inosine/uridine-preferring nucleoside hydrolase Caul_2809 86 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 167644008 Nonpathogen - hypothetical protein Caul_0035 1 None None None 167648770 Nonpathogen - hypothetical protein Caul_4815 1 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 167645354 Nonpathogen - hypothetical protein Caul_1389 4 None None None 167646072 Common - hypothetical protein Caul_2109 4 None None None 167645546 Common - methyltransferase Caul_1581 82 COG4301 COG4301, Uncharacterized conserved protein Function unknown 167646687 Common - glycosyl transferase family 2 Caul_2725 101 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 167646522 Common - ribonucleotide reductase-related protein Caul_2560 48 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 167645830 Common - tryptophan halogenase Caul_1866 16 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 167644729 Common - lysine 2,3-aminomutase YodO family protein Caul_0763 125 COG1509 KamA, Lysine 2,3-aminomutase Amino acid transport and metabolism 167648943 Nonpathogen - heme exporter protein CcmB Caul_4988 1 COG2386 CcmB, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 167648967 Common - dephospho-CoA kinase Caul_5012 191 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 167646041 Common - glycosyl transferase group 1 Caul_2078 172 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 167644904 Common - Methyltransferase type 11 Caul_0938 91 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 167644926 Common - lipolytic protein G-D-S-L family Caul_0961 17 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 167645801 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Caul_1837 116 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 167646639 Common - TonB-dependent receptor plug Caul_2677 100 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167644593 Common - Gluconolactonase Caul_0625 56 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 167648235 Common - major facilitator superfamily MFS_1 Caul_4279 124 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167648011 Common - MaoC domain protein dehydratase Caul_4051 104 COG2030 MaoC, Acyl dehydratase Lipid metabolism 167645236 Common - protein of unknown function DUF1295 Caul_1271 38 COG3752 COG3752, Predicted membrane protein Function unknown 167646133 Common - ammonium transporter Caul_2170 201 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 167644506 Common - Glutathione S-transferase domain Caul_0537 89 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167644957 Common - OmpA/MotB domain protein Caul_0992 162 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 167644655 Nonpathogen - hypothetical protein Caul_0687 2 None None None 167646423 Common - Alcohol dehydrogenase GroES domain protein Caul_2461 211 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 167648849 Common - thioesterase superfamily protein Caul_4894 30 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 167644092 Common - Uroporphyrinogen III synthase HEM4 Caul_0119 33 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 167648582 Common - PTS system fructose subfamily IIA component Caul_4627 96 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 167644251 Common - CheA signal transduction histidine kinase Caul_0279 162 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 167645154 Nonpathogen - hypothetical protein Caul_1189 1 None None None 167646148 Common - hypothetical protein Caul_2185 33 COG3812 COG3812, Uncharacterized protein conserved in bacteria Function unknown 167648557 Common - TonB-dependent receptor Caul_4602 92 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 167646103 Common - Beta-glucosidase Caul_2140 101 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 167645768 Common - transcriptional regulator, AraC family Caul_1804 76 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 167647834 Common - acyl-CoA dehydrogenase domain protein Caul_3873 141 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 167647112 Common - hypothetical protein Caul_3150 31 COG5458 COG5458, Uncharacterized conserved protein Function unknown 167646586 Common - Domain of unknown function DUF1801 Caul_2624 13 COG5649 COG5649, Uncharacterized conserved protein Function unknown 167647460 Common - Phage-related protein tail component-like protein Caul_3498 13 COG4733 COG4733, Phage-related protein, tail component Function unknown 167645508 Common - hypothetical protein Caul_1543 11 None None None 167644861 Common - NAD(P)(+) transhydrogenase (AB-specific) Caul_0895 123 COG1282 PntB, NAD/NADP transhydrogenase beta subunit Energy production and conversion 167646435 Common - acriflavin resistance protein Caul_2473 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 167644662 Common - NUDIX hydrolase Caul_0694 127 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 167648465 Common - peptidase U62 modulator of DNA gyrase Caul_4510 170 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 167646446 Common - protein of unknown function DUF983 Caul_2484 24 COG5349 COG5349, Uncharacterized protein conserved in bacteria Function unknown 167645813 Common - transposase and inactivated derivatives-like protein Caul_1849 46 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 167644643 Common - protein of unknown function DUF526 Caul_0675 23 COG2960 COG2960, Uncharacterized protein conserved in bacteria Function unknown 167644759 Nonpathogen - hypothetical protein Caul_0793 1 None None None 167648501 Common - two component transcriptional regulator, winged helix family Caul_4546 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167647109 Common - heat shock protein DnaJ domain protein Caul_3147 19 COG2214 CbpA, DnaJ-class molecular chaperone Posttranslational modification, protein turnover, chaperones 167648693 Common - ATP synthase F1, gamma subunit Caul_4738 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 167646584 Common - Activator of Hsp90 ATPase 1 family protein Caul_2622 22 COG3832 COG3832, Uncharacterized conserved protein Function unknown 167644724 Common - hypothetical protein Caul_0758 30 COG5572 COG5572, Predicted integral membrane protein Function unknown 167644804 Common - PilT protein domain protein Caul_0838 16 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 167645246 Common - efflux transporter, RND family, MFP subunit Caul_1281 159 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 167646382 Common - Rubrerythrin Caul_2420 73 COG1592 COG1592, Rubrerythrin Energy production and conversion 167648306 Common - two component transcriptional regulator, winged helix family Caul_4351 220 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167648836 Common - transcriptional regulator, LysR family Caul_4881 189 COG0583 LysR, Transcriptional regulator Transcription 167646240 Common - transcriptional regulator, XRE family Caul_2278 42 COG1396 HipB, Predicted transcriptional regulators Transcription 167648853 Common - ATP dependent DNA ligase Caul_4898 104 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 167646037 Common - transcriptional regulator, LacI family Caul_2074 123 COG1609 PurR, Transcriptional regulators Transcription 167647353 Common - NADH:flavin oxidoreductase/NADH oxidase Caul_3391 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 167645260 Common - urocanate hydratase Caul_1295 97 COG2987 HutU, Urocanate hydratase Amino acid transport and metabolism 167646273 Common - multicopper oxidase type 3 Caul_2311 134 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 167646566 Common - TIM-barrel protein, nifR3 family Caul_2604 205 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 167648008 Common - methylated-DNA--protein-cysteine methyltransferase Caul_4048 206 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 167645875 Common - TonB-dependent receptor Caul_1911 101 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167646030 Common - glycoside hydrolase family 30 Caul_2067 25 COG5520 COG5520, O-Glycosyl hydrolase Cell envelope biogenesis, outer membrane 167646711 Common - Enoyl-CoA hydratase/isomerase Caul_2749 179 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 167648678 Common - peptidase M23B Caul_4723 133 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 167646570 Common - two component, sigma54 specific, transcriptional regulator, Fis family Caul_2608 174 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 167646746 Common - Glutathione S-transferase domain Caul_2784 101 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167647808 Common - 3-oxoacid CoA-transferase, A subunit Caul_3847 94 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 167646263 Common - cation efflux protein Caul_2301 53 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 167644345 Common - protein of unknown function DUF427 Caul_0373 48 COG2343 COG2343, Uncharacterized protein conserved in bacteria Function unknown 167645587 Common - ribosomal protein S17 Caul_1623 220 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 167646285 Common - hypothetical protein Caul_2323 16 None None None 167647469 Nonpathogen - hypothetical protein Caul_3507 1 None None None 167644527 Common - Redoxin domain protein Caul_0559 12 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 167646021 Common - NADH:flavin oxidoreductase/NADH oxidase Caul_2058 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 167647739 Common - protein of unknown function DUF849 Caul_3777 62 COG3246 COG3246, Uncharacterized conserved protein Function unknown 167648698 Nonpathogen - hypothetical protein Caul_4743 2 None None None 167644263 Common - transcriptional regulator, GntR family Caul_0291 137 COG2188 PhnF, Transcriptional regulators Transcription 167644846 Nonpathogen - hypothetical protein Caul_0880 1 None None None 167647758 Common - hypothetical protein Caul_3797 21 COG4683 COG4683, Uncharacterized protein conserved in bacteria Function unknown 167647967 Common - TonB-dependent receptor Caul_4007 50 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647625 Common - UDP-N-acetylmuramate--alanine ligase Caul_3663 210 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 167645090 Common - transposase and inactivated derivative Caul_1125 70 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 167647012 Common - 3-hydroxyisobutyrate dehydrogenase Caul_3050 151 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 167646028 Common - PASs1-related protein Caul_2065 19 COG2850 COG2850, Uncharacterized conserved protein Function unknown 167646727 Common - CTP synthase Caul_2765 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 167647278 Common - export-related chaperone CsaA Caul_3316 81 COG0073 ARC1, EMAP domain General function prediction only 167648071 Common - transcriptional regulator, CarD family Caul_4112 83 COG1329 COG1329, Transcriptional regulators, similar to M. xanthus CarD Transcription 167647771 Common - protein of unknown function DUF736 Caul_3810 26 COG5489 COG5489, Uncharacterized conserved protein Function unknown 167647499 Nonpathogen - hypothetical protein Caul_3537 2 None None None 167648795 Common - succinate dehydrogenase, cytochrome b556 subunit Caul_4840 32 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 167644077 Common - integration host factor, beta subunit Caul_0104 205 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 167648141 Common - Resolvase domain Caul_4182 65 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 167648643 Common - Glucose-6-phosphate isomerase Caul_4688 178 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 167646345 Common - TonB-dependent receptor Caul_2383 102 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167648217 Common - hypothetical protein Caul_4261 14 None None None 167649018 Common - Phytanoyl-CoA dioxygenase Caul_5063 10 COG5285 COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin Secondary metabolites biosynthesis, transport, and catabolism 167647775 Common - hypothetical protein Caul_3814 8 None None None 167644211 Common - protein of unknown function DUF484 Caul_0239 16 COG3159 COG3159, Uncharacterized protein conserved in bacteria Function unknown 167648866 Common - dTDP-4-dehydrorhamnose reductase Caul_4911 164 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 167644890 Common - arginine biosynthesis bifunctional protein ArgJ Caul_0924 167 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 167647122 Common - surface presentation of antigens (SPOA) protein Caul_3160 51 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 167645867 Common - protein of unknown function DUF35 Caul_1903 50 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 167646677 Common - CDP-glucose 4,6-dehydratase Caul_2715 210 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167647265 Common - response regulator receiver modulated CheB methylesterase Caul_3303 220 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 167645398 Common - flagellar basal body-associated protein FliL Caul_1433 16 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 167647617 Common - transcriptional regulator, AsnC family Caul_3655 144 COG1522 Lrp, Transcriptional regulators Transcription 167645310 Nonpathogen - CsbD family protein Caul_1345 1 COG3237 COG3237, Uncharacterized protein conserved in bacteria Function unknown 167647960 Common - hypothetical protein Caul_4000 35 COG3970 COG3970, Fumarylacetoacetate (FAA) hydrolase family protein General function prediction only 167646079 Common - transcriptional regulator, LuxR family Caul_2116 45 COG2771 CsgD, DNA-binding HTH domain-containing proteins Transcription 167646555 Common - cysteine desulfurase, SufS subfamily Caul_2593 240 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 167644747 Nonpathogen - hypothetical protein Caul_0781 3 None None None 167644082 Common - putative thiol-disulphide oxidoreductase DCC Caul_0109 29 COG3011 COG3011, Uncharacterized protein conserved in bacteria Function unknown 167647762 Common - SMC domain protein Caul_3801 10 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 167645418 Common - hypothetical protein Caul_1453 47 COG1407 COG1407, Predicted ICC-like phosphoesterases General function prediction only 167646456 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_2494 150 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167646611 Common - anti-FecI sigma factor, FecR Caul_2649 47 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 167647322 Common - thioesterase superfamily protein Caul_3360 43 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 167647078 Nonpathogen - hypothetical protein Caul_3116 1 None None None 167645224 Nonpathogen - hypothetical protein Caul_1259 1 None None None 167647561 Common - Integrase catalytic region Caul_3599 146 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 167648782 Common - short-chain dehydrogenase/reductase SDR Caul_4827 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167646654 Nonpathogen - hypothetical protein Caul_2692 1 None None None 167644234 Common - phosphate-selective porin O and P Caul_0262 21 COG3746 OprP, Phosphate-selective porin Inorganic ion transport and metabolism 167644934 Common - metallophosphoesterase Caul_0969 8 None None None 167647072 Common - protein of unknown function DUF815 Caul_3110 89 COG2607 COG2607, Predicted ATPase (AAA+ superfamily) General function prediction only 167645897 Common - short-chain dehydrogenase/reductase SDR Caul_1933 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167648973 Common - hypothetical protein Caul_5018 83 COG1981 COG1981, Predicted membrane protein Function unknown 167644231 Common - phosphonate ABC transporter, ATPase subunit Caul_0259 249 COG3638 COG3638, ABC-type phosphate/phosphonate transport system, ATPase component Inorganic ion transport and metabolism 167646065 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_2102 22 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167645843 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Caul_1879 242 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 167644897 Nonpathogen - hypothetical protein Caul_0931 1 None None None 167645672 Common - ABC transporter related Caul_1708 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 167646156 Common - sulfate ABC transporter, inner membrane subunit CysT Caul_2193 233 COG0555 CysU, ABC-type sulfate transport system, permease component Posttranslational modification, protein turnover, chaperones 167645631 Common - alpha/beta hydrolase fold Caul_1667 20 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167645561 Nonpathogen - hypothetical protein Caul_1596 1 None None None 167647079 Common - Sec-independent protein translocase, TatC subunit Caul_3117 205 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 167645371 Common - Domain of unknown function DUF1794 Caul_1406 12 COG5514 COG5514, Uncharacterized conserved protein Function unknown 167646301 Nonpathogen - hypothetical protein Caul_2339 1 None None None 167648657 Common - NAD(P)H dehydrogenase (quinone) Caul_4702 71 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 167648476 Common - glycosyl transferase family 2 Caul_4521 168 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 167645476 Common - putative addiction module antidote protein, CopG/Arc/MetJ family Caul_1511 16 COG3609 COG3609, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain Transcription 167644443 Common - integrase family protein Caul_0474 15 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 167647364 Common - methionine synthase Caul_3402 168 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 167645205 Common - protein of unknown function DUF1491 Caul_1240 30 COG5447 COG5447, Uncharacterized conserved protein Function unknown 167644686 Common - protein of unknown function DUF21 Caul_0718 219 COG4536 CorB, Putative Mg2+ and Co2+ transporter CorB Inorganic ion transport and metabolism 167646339 Common - transcriptional regulator, LysR family Caul_2377 166 COG0583 LysR, Transcriptional regulator Transcription 167647591 Common - Methylmalonyl-CoA mutase Caul_3629 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 167643987 Common - ribosomal-protein-alanine acetyltransferase Caul_0014 190 COG0456 RimI, Acetyltransferases General function prediction only 167645640 Nonpathogen - hypothetical protein Caul_1676 24 COG2266 COG2266, GTP:adenosylcobinamide-phosphate guanylyltransferase Coenzyme metabolism 167644857 Common - NAD(P)(+) transhydrogenase (AB-specific) Caul_0891 166 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 167648080 Common - acyltransferase 3 Caul_4121 27 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 167647155 Nonpathogen - hypothetical protein Caul_3193 2 None None None 167647027 Common - Alcohol dehydrogenase zinc-binding domain protein Caul_3065 187 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 167645590 Common - ribosomal protein L5 Caul_1626 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 167644318 Common - TonB-dependent receptor Caul_0346 73 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167644625 Common - hypothetical protein Caul_0657 5 None None None 167648640 Nonpathogen - hypothetical protein Caul_4685 1 None None None 167647092 Common - Lysine exporter protein (LYSE/YGGA) Caul_3130 125 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 167645107 Common - integrase family protein Caul_1142 102 COG0582 XerC, Integrase DNA replication, recombination, and repair 167648766 Common - glycosyl transferase family 2 Caul_4811 51 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 167644993 Common - acyltransferase 3 Caul_1028 28 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 167646155 Nonpathogen - hypothetical protein Caul_2192 6 None None None 167644026 Nonpathogen - hypothetical protein Caul_0053 1 None None None 167645568 Common - Integral membrane protein TerC Caul_1604 50 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 167648682 Common - NUDIX hydrolase Caul_4727 117 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 167648452 Common - peptidase M16 domain protein Caul_4497 199 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 167644967 Common - transcriptional regulator, HxlR family Caul_1002 83 COG1733 COG1733, Predicted transcriptional regulators Transcription 167648224 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_4268 154 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167645981 Common - PilT protein domain protein Caul_2018 35 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 167646321 Nonpathogen - hypothetical protein Caul_2359 2 None None None 167644356 Common - methionine biosynthesis protein MetW Caul_0384 67 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 167647503 Common - hypothetical protein Caul_3541 10 COG3577 COG3577, Predicted aspartyl protease General function prediction only 167645626 Common - 2-deoxycytidine 5-triphosphate deaminase Caul_1662 25 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 167648905 Common - Glutamate synthase (ferredoxin) Caul_4950 202 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 167648213 Common - protein of unknown function DUF583 Caul_4257 47 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 167645761 Common - NAD-dependent epimerase/dehydratase Caul_1797 149 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167647403 Common - Endothelin-converting enzyme 1 Caul_3441 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 167644824 Common - transporter, putative Caul_0858 19 None None None 167644843 Nonpathogen - hypothetical protein Caul_0877 3 None None None 167647006 Common - NusB antitermination factor Caul_3044 185 COG0781 NusB, Transcription termination factor Transcription 167645021 Common - hypothetical protein Caul_1056 5 None None None 167649009 Common - 20S proteasome A and B subunits Caul_5054 149 COG5405 HslV, ATP-dependent protease HslVU (ClpYQ), peptidase subunit Posttranslational modification, protein turnover, chaperones 167644347 Common - putative transposase of insertion sequence ISRm2011-2, orfA protein Caul_0375 20 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 167645145 Common - FAD dependent oxidoreductase Caul_1180 82 COG2509 COG2509, Uncharacterized FAD-dependent dehydrogenases General function prediction only 167645423 Common - transferase hexapeptide repeat containing protein Caul_1458 212 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 167646884 Common - Pyridoxal-5'-phosphate-dependent protein beta subunit Caul_2922 227 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 167647285 Common - transcriptional regulator, TetR family Caul_3323 58 COG1309 AcrR, Transcriptional regulator Transcription 167648256 Common - esterase, PHB depolymerase family Caul_4301 33 COG3509 LpqC, Poly(3-hydroxybutyrate) depolymerase Secondary metabolites biosynthesis, transport, and catabolism 167645277 Common - transcriptional regulator, TetR family Caul_1312 85 COG1309 AcrR, Transcriptional regulator Transcription 167644971 Common - flagellin, putative Caul_1006 30 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 167647448 Common - phage major capsid protein, HK97 family Caul_3486 49 COG4653 COG4653, Predicted phage phi-C31 gp36 major capsid-like protein General function prediction only 167645389 Nonpathogen - hypothetical protein Caul_1424 1 None None None 167648676 Common - iojap-like protein Caul_4721 201 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 167646169 Common - response regulator receiver protein Caul_2206 20 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 167645663 Nonpathogen - hypothetical protein Caul_1699 1 None None None 167647851 Common - cytochrome c-type biogenesis protein CcmF Caul_3891 165 COG1138 CcmF, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 167647849 Common - protease Do Caul_3889 223 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 167647062 Common - outer membrane assembly lipoprotein YfiO Caul_3100 128 COG4105 ComL, DNA uptake lipoprotein General function prediction only 167644138 Common - heat-inducible transcription repressor HrcA Caul_0166 148 COG1420 HrcA, Transcriptional regulator of heat shock gene Transcription 167647214 Common - TonB-dependent receptor plug Caul_3252 74 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167648298 Nonpathogen - hypothetical protein Caul_4343 1 None None None 167649016 Common - Beta-ketoacyl synthase Caul_5061 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167648837 Common - GumN family protein Caul_4882 2 COG3735 COG3735, Uncharacterized protein conserved in bacteria Function unknown 167645510 Common - Altronate dehydratase Caul_1545 73 COG2721 UxaA, Altronate dehydratase Carbohydrate transport and metabolism 167644737 Common - putative transcriptional regulator, GntR family Caul_0771 219 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 167647605 Common - alpha/beta hydrolase fold Caul_3643 103 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 167644743 Common - Peroxidase Caul_0777 207 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 167644396 Nonpathogen - transcriptional regulator, TetR family Caul_0424 2 COG1309 AcrR, Transcriptional regulator Transcription 167645062 Common - Tail Collar domain protein Caul_1097 34 COG4675 MdpB, Microcystin-dependent protein Function unknown 167644688 Common - multi-sensor hybrid histidine kinase Caul_0720 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167646001 Common - hypothetical protein Caul_2038 29 None None None 167647326 Nonpathogen - endodeoxyribonuclease RusA Caul_3364 3 COG4570 Rus, Holliday junction resolvase DNA replication, recombination, and repair 167646535 Common - N-acetylmuramoyl-L-alanine amidase Caul_2573 171 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 167645779 Nonpathogen - hypothetical protein Caul_1815 11 None None None 167645947 Nonpathogen - hypothetical protein Caul_1984 1 None None None 167648804 Common - protein of unknown function UPF0079 Caul_4849 203 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 167644375 Common - HipA domain protein Caul_0403 75 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 167646911 Nonpathogen - hypothetical protein Caul_2949 2 None None None 167644736 Nonpathogen - hypothetical protein Caul_0770 1 None None None 167648887 Common - ABC transporter related Caul_4932 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 167646309 Common - copper resistance protein CopC Caul_2347 7 COG2372 CopC, Uncharacterized protein, homolog of Cu resistance protein CopC General function prediction only 167645624 Common - ApaG domain protein Caul_1660 89 COG2967 ApaG, Uncharacterized protein affecting Mg2+/Co2+ transport Inorganic ion transport and metabolism 167645314 Common - Enoyl-CoA hydratase/isomerase Caul_1349 175 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 167647148 Common - RND efflux system, outer membrane lipoprotein, NodT family Caul_3186 118 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 167645930 Common - hypothetical protein Caul_1966 17 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 167644757 Common - ThiJ/PfpI domain protein Caul_0791 116 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 167648827 Nonpathogen - hypothetical protein Caul_4872 1 None None None 167645099 Common - transcriptional regulator, MarR family Caul_1134 26 COG1846 MarR, Transcriptional regulators Transcription 167644262 Common - Glutamine--fructose-6-phosphate transaminase (isomerizing) Caul_0290 224 COG2222 AgaS, Predicted phosphosugar isomerases Cell envelope biogenesis, outer membrane 167648634 Common - ATP phosphoribosyltransferase Caul_4679 57 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 167643995 Common - PhoH family protein Caul_0022 199 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 167648133 Common - serine/threonine protein kinase Caul_4174 138 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 167647894 Common - FAD dependent oxidoreductase Caul_3934 83 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 167644645 Common - pyrroline-5-carboxylate reductase Caul_0677 191 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 167644204 Common - 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase Caul_0232 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 167647709 Nonpathogen - hypothetical protein Caul_3747 2 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 167647153 Nonpathogen - hypothetical protein Caul_3191 1 None None None 167647147 Common - transcriptional regulator, TetR family Caul_3185 129 COG1309 AcrR, Transcriptional regulator Transcription 167648014 Common - peptidase S1 and S6 chymotrypsin/Hap Caul_4054 220 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 167644427 Common - transcriptional regulator, LysR family Caul_0455 182 COG0583 LysR, Transcriptional regulator Transcription 167645552 Common - two component transcriptional regulator, winged helix family Caul_1587 219 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167646989 Common - Alkaline phosphatase Caul_3027 86 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 167645997 Common - P-type conjugative transfer protein TrbG Caul_2034 48 COG3504 VirB9, Type IV secretory pathway, VirB9 components Intracellular trafficking and secretion 167645905 Common - TonB-dependent receptor Caul_1941 67 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647755 Common - DNA repair protein RadC Caul_3794 175 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 167645899 Common - FAD dependent oxidoreductase Caul_1935 78 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 167646602 Common - transcriptional regulator, AraC family Caul_2640 140 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 167647534 Common - integral membrane sensor hybrid histidine kinase Caul_3572 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 167645033 Common - Enoyl-CoA hydratase/isomerase Caul_1068 180 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 167645749 Common - arsenate reductase Caul_1785 88 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 167648050 Common - outer membrane insertion C-terminal signal Caul_4091 24 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167648196 Common - osmosensitive K+ channel signal transduction histidine kinase Caul_4239 221 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 167645985 Common - Exonuclease RNase T and DNA polymerase III Caul_2022 35 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 167646831 Common - short-chain dehydrogenase/reductase SDR Caul_2869 235 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 167647485 Common - Beta-lactamase Caul_3523 65 COG2367 PenP, Beta-lactamase class A Defense mechanisms 167645688 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Caul_1724 192 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 167646208 Common - transcriptional regulator, XRE family Caul_2246 8 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 167645742 Common - glycoside hydrolase 15-related Caul_1778 71 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 167644915 Common - aspartate kinase Caul_0950 234 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 167644978 Common - flagellar motor switch protein FliG Caul_1013 125 COG1536 FliG, Flagellar motor switch protein Cell motility and secretion 167646048 Common - Capsule polysaccharide biosynthesis protein Caul_2085 30 COG3563 KpsC, Capsule polysaccharide export protein Cell envelope biogenesis, outer membrane 167645939 Common - amidohydrolase 2 Caul_1976 21 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 167644762 Common - transcriptional regulator, LysR family Caul_0796 120 COG0583 LysR, Transcriptional regulator Transcription 167647872 Nonpathogen - uncharacterized phage protein Caul_3912 1 None None None 167646411 Common - zinc-binding alcohol dehydrogenase family protein Caul_2449 202 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 167648771 Common - Non-specific protein-tyrosine kinase Caul_4816 167 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 167648548 Common - hypothetical protein Caul_4593 8 None None None 167647221 Nonpathogen - hypothetical protein Caul_3259 1 None None None 167648562 Common - protein of unknown function DUF1080 Caul_4607 6 None None None 167644165 Common - ribosomal protein L27 Caul_0193 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 167645177 Common - pentapeptide repeat protein Caul_1212 94 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 167648488 Common - FAD linked oxidase domain protein Caul_4533 15 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 167648748 Common - glycoside hydrolase family 16 Caul_4793 47 COG2273 SKN1, Beta-glucanase/Beta-glucan synthetase Carbohydrate transport and metabolism 167644960 Common - Glutathione S-transferase domain Caul_0995 95 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167646932 Common - hypothetical protein Caul_2970 4 COG0392 COG0392, Predicted integral membrane protein Function unknown 167647043 Common - efflux transporter, RND family, MFP subunit Caul_3081 160 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 167647985 Common - efflux transporter, RND family, MFP subunit Caul_4025 142 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 167648954 Common - hypothetical protein Caul_4999 42 COG3651 COG3651, Uncharacterized protein conserved in bacteria Function unknown 167647297 Common - Glutathione S-transferase domain Caul_3335 69 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167646895 Common - ABC-1 domain protein Caul_2933 185 COG0661 AarF, Predicted unusual protein kinase General function prediction only 167647107 Nonpathogen - phasin family protein Caul_3145 17 COG5490 COG5490, Uncharacterized conserved protein Function unknown 167648604 Common - short-chain dehydrogenase/reductase SDR Caul_4649 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167644100 Nonpathogen - hypothetical protein Caul_0127 1 None None None 167647914 Common - succinic semialdehyde dehydrogenase Caul_3954 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167648412 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Caul_4457 25 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 167647419 Nonpathogen - hypothetical protein Caul_3457 1 None None None 167644571 Common - transcriptional regulator, XRE family Caul_0603 11 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 167645884 Common - short-chain dehydrogenase/reductase SDR Caul_1920 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167647957 Common - transcriptional regulator, XRE family Caul_3997 42 COG1396 HipB, Predicted transcriptional regulators Transcription 167648911 Common - OstA family protein Caul_4956 35 COG1934 COG1934, Uncharacterized protein conserved in bacteria Function unknown 167646483 Common - aminodeoxychorismate lyase Caul_2521 185 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 167646094 Common - Mannose-6-phosphate isomerase Caul_2131 21 COG2942 COG2942, N-acyl-D-glucosamine 2-epimerase Carbohydrate transport and metabolism 167647564 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase Caul_3602 217 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 167648189 Common - nitroreductase Caul_4232 110 COG0778 NfnB, Nitroreductase Energy production and conversion 167647667 Common - amidase, hydantoinase/carbamoylase family Caul_3705 84 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 167645346 Common - Endoribonuclease L-PSP Caul_1381 16 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 167646529 Common - thiamine biosynthesis protein ThiS Caul_2567 73 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 167646222 Nonpathogen - hypothetical protein Caul_2260 3 None None None 167645032 Common - crotonyl-CoA reductase Caul_1067 89 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 167645257 Common - glycoside hydrolase family 31 Caul_1292 82 COG1501 COG1501, Alpha-glucosidases, family 31 of glycosyl hydrolases Carbohydrate transport and metabolism 167647470 Common - hypothetical protein Caul_3508 13 COG0824 FcbC, Predicted thioesterase General function prediction only 167648874 Common - NAD-dependent epimerase/dehydratase Caul_4919 225 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167648163 Common - alpha/beta hydrolase fold Caul_4204 73 COG1647 COG1647, Esterase/lipase General function prediction only 167647710 Nonpathogen - hypothetical protein Caul_3748 1 None None None 167646626 Common - cysteine dioxygenase type I Caul_2664 23 COG5553 COG5553, Predicted metal-dependent enzyme of the double-stranded beta helix superfamily General function prediction only 167647641 Common - FMN-binding negative transcriptional regulator Caul_3679 60 COG2808 PaiB, Transcriptional regulator Transcription 167645047 Common - hypothetical protein Caul_1082 147 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 167646354 Common - Aldehyde Dehydrogenase_ Caul_2392 210 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 167646387 Common - protein of unknown function DUF125 transmembrane Caul_2425 67 COG1814 COG1814, Uncharacterized membrane protein Function unknown 167648706 Common - TonB-dependent receptor Caul_4751 108 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167646419 Common - transcriptional regulator, Crp/Fnr family Caul_2457 136 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 167648433 Common - FAD linked oxidase domain protein Caul_4478 196 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 167644784 Common - Pirin domain protein Caul_0818 142 COG1741 COG1741, Pirin-related protein General function prediction only 167644122 Common - ROK family protein Caul_0149 101 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 167648148 Common - type II secretion system protein Caul_4189 77 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 167646370 Common - SapC family protein Caul_2408 10 None None None 167645721 Common - 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase Caul_1757 27 COG3717 KduI, 5-keto 4-deoxyuronate isomerase Carbohydrate transport and metabolism 167644955 Common - peptidase M48 Ste24p Caul_0990 120 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 167646701 Common - transport system permease protein Caul_2739 182 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 167645187 Common - lipid A biosynthesis acyltransferase Caul_1222 120 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 167644520 Common - Integrase catalytic region Caul_0552 146 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 167648104 Nonpathogen - protein of unknown function DUF1328 Caul_4145 1 COG5487 COG5487, Small integral membrane protein Function unknown 167645772 Nonpathogen - hypothetical protein Caul_1808 2 None None None 167645782 Nonpathogen - hypothetical protein Caul_1818 1 None None None 167647302 Common - secretion protein HlyD family protein Caul_3340 7 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 167647717 Common - TonB-dependent receptor plug Caul_3755 16 COG4371 COG4371, Predicted membrane protein Function unknown 167646351 Common - protein of unknown function DUF1348 Caul_2389 49 COG3558 COG3558, Uncharacterized protein conserved in bacteria Function unknown 167644790 Nonpathogen - hypothetical protein Caul_0824 1 None None None 167648520 Common - NAD(P)H dehydrogenase (quinone) Caul_4565 38 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 167645323 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Caul_1358 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 167647035 Common - transcriptional regulator, MarR family Caul_3073 101 COG1846 MarR, Transcriptional regulators Transcription 167645612 Common - major facilitator superfamily MFS_1 Caul_1648 216 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167646201 Nonpathogen - hypothetical protein Caul_2239 1 None None None 167647100 Common - Na+/H+ antiporter Caul_3138 103 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 167645960 Common - hypothetical protein Caul_1997 3 None None None 167647632 Common - phospho-N-acetylmuramoyl-pentapeptide-transferase Caul_3670 216 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 167646665 Common - methyltransferase small Caul_2703 92 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 167647733 Common - HpcH/HpaI aldolase Caul_3771 74 COG3836 HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase Carbohydrate transport and metabolism 167648739 Nonpathogen - hypothetical protein Caul_4784 2 None None None 167645171 Nonpathogen - hypothetical protein Caul_1206 1 None None None 167646464 Common - amidophosphoribosyltransferase Caul_2502 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 167648932 Common - tryptophan synthase, alpha subunit Caul_4977 211 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 167644492 Common - transcriptional regulator, HxlR family Caul_0523 131 COG1733 COG1733, Predicted transcriptional regulators Transcription 167647611 Nonpathogen - hypothetical protein Caul_3649 1 None None None 167648114 Nonpathogen - hypothetical protein Caul_4155 8 None None None 167648749 Common - NAD-dependent epimerase/dehydratase Caul_4794 61 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 167648350 Common - Ribonuclease H Caul_4395 179 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 167646973 Common - single-stranded-DNA-specific exonuclease RecJ Caul_3011 191 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 167646278 Common - hypothetical protein Caul_2316 13 COG3544 COG3544, Uncharacterized protein conserved in bacteria Function unknown 167644081 Common - Saccharopine dehydrogenase Caul_0108 9 COG1748 LYS9, Saccharopine dehydrogenase and related proteins Amino acid transport and metabolism 167645911 Nonpathogen - hypothetical protein Caul_1947 1 None None None 167648624 Common - hypothetical protein Caul_4669 11 None None None 167648512 Common - hypothetical protein Caul_4557 25 COG4095 COG4095, Uncharacterized conserved protein Function unknown 167648325 Nonpathogen - protein of unknown function DUF1159 Caul_4370 12 COG5389 COG5389, Uncharacterized protein conserved in bacteria Function unknown 167645498 Common - transcriptional regulator, LuxR family Caul_1533 126 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 167646786 Common - NADH-quinone oxidoreductase, chain I Caul_2824 194 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 167646872 Common - ABC transporter related Caul_2910 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 167649002 Common - hypothetical protein Caul_5047 19 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 167645466 Common - amidohydrolase Caul_1501 167 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 167648536 Common - 3-deoxy-D-manno-octulosonate cytidylyltransferase Caul_4581 137 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 167649034 Common - ribosomal protein S20 Caul_5079 93 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 167648039 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Caul_4079 74 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 167649013 Common - Glyoxylate reductase Caul_5058 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 167646472 Common - ribosomal protein L9 Caul_2510 216 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 167645110 Nonpathogen - hypothetical protein Caul_1145 2 None None None 167648579 Common - adenylate cyclase Caul_4624 69 COG3025 COG3025, Uncharacterized conserved protein Function unknown 167644472 Common - class II aldolase/adducin family protein Caul_0503 119 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 167645436 Common - Glutathione S-transferase domain Caul_1471 86 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 167644156 Common - Peptidyl-dipeptidase A Caul_0184 16 None None None 167645067 Common - putative transposase Caul_1102 68 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 167644071 Common - hypothetical protein Caul_0098 11 None None None 167648206 Common - Integrase catalytic region Caul_4250 146 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 167646393 Common - hypothetical protein Caul_2431 25 None None None 167645425 Common - UvrD/REP helicase Caul_1460 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 167648897 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Caul_4942 168 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 167646395 Common - hypothetical protein Caul_2433 15 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 167647345 Common - protein of unknown function DUF924 Caul_3383 63 COG3803 COG3803, Uncharacterized protein conserved in bacteria Function unknown 167644471 Common - amidohydrolase 2 Caul_0502 41 COG3618 COG3618, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 167644545 Common - short-chain dehydrogenase/reductase SDR Caul_0577 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 167644732 Common - Phosphoglycerate kinase Caul_0766 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 167644030 Nonpathogen - molybdopterin converting factor, subunit 1 Caul_0057 1 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 167644452 Common - DNA binding domain protein, excisionase family Caul_0483 94 COG0372 GltA, Citrate synthase Energy production and conversion 167648399 Nonpathogen - hypothetical protein Caul_4444 1 None None None 167644305 Nonpathogen - hypothetical protein Caul_0333 2 None None None 167646116 Common - AMP-dependent synthetase and ligase Caul_2153 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167645754 Common - TonB-dependent receptor Caul_1790 67 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167645582 Common - ribosomal protein S19 Caul_1618 238 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 167646327 Common - Sarcosine oxidase delta subunit heterotetrameric Caul_2365 35 COG4311 SoxD, Sarcosine oxidase delta subunit Amino acid transport and metabolism 167644287 Common - glycoside hydrolase clan GH-D Caul_0315 13 COG3345 GalA, Alpha-galactosidase Carbohydrate transport and metabolism 167646939 Common - efflux transporter, RND family, MFP subunit Caul_2977 154 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 167648663 Common - 2-dehydropantoate 2-reductase Caul_4708 94 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 167645923 Nonpathogen - hypothetical protein Caul_1959 1 COG3184 COG3184, Uncharacterized protein conserved in bacteria Function unknown 167648034 Common - methylated-DNA--protein-cysteine methyltransferase Caul_4074 208 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 167647571 Common - 5-carboxymethyl-2-hydroxymuconate Delta-isomerase Caul_3609 184 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 167646217 Common - Integrase catalytic region Caul_2255 79 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 167648723 Common - major facilitator superfamily MFS_1 Caul_4768 150 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 167648423 Common - phosphoserine aminotransferase Caul_4468 67 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 167648075 Common - beta-lactamase-like protein Caul_4116 44 COG1237 COG1237, Metal-dependent hydrolases of the beta-lactamase superfamily II General function prediction only 167645823 Common - TonB-dependent receptor Caul_1859 43 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167648572 Common - transcriptional regulator, LysR family Caul_4617 125 COG0583 LysR, Transcriptional regulator Transcription 167647434 Nonpathogen - hypothetical protein Caul_3472 1 None None None 167643974 Common - chromosomal replication initiator protein DnaA Caul_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 167646949 Common - phospholipase C, phosphocholine-specific Caul_2987 33 COG3511 PlcC, Phospholipase C Cell envelope biogenesis, outer membrane 167645087 Common - peptidase T2 asparaginase 2 Caul_1122 84 COG1446 COG1446, Asparaginase Amino acid transport and metabolism 167648449 Common - GCN5-related N-acetyltransferase Caul_4494 117 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 167648364 Nonpathogen - hypothetical protein Caul_4409 2 None None None 167647310 Nonpathogen - hypothetical protein Caul_3348 1 None None None 167646954 Common - sulfotransferase Caul_2992 51 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 167644280 Common - TonB-dependent receptor Caul_0308 61 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167647392 Common - aminopeptidase N Caul_3430 161 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 167644815 Common - Activator of Hsp90 ATPase 1 family protein Caul_0849 46 COG3832 COG3832, Uncharacterized conserved protein Function unknown 167647456 Common - hypothetical protein Caul_3494 15 None None None 167645650 Common - phosphopantetheine-binding Caul_1686 10 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 167647487 Nonpathogen - hypothetical protein Caul_3525 2 None None None 167644583 Common - methyl-accepting chemotaxis sensory transducer Caul_0615 148 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 167646336 Common - hypothetical protein Caul_2374 11 COG3608 COG3608, Predicted deacylase General function prediction only 167645732 Common - protein of unknown function DUF661 Caul_1768 9 COG3801 COG3801, Uncharacterized protein conserved in bacteria Function unknown 167645269 Common - protein of unknown function DUF303 acetylesterase putative Caul_1304 15 None None None 167644270 Common - hypothetical protein Caul_0298 6 None None None 167647903 Common - FAD dependent oxidoreductase Caul_3943 121 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 167645958 Common - hypothetical protein Caul_1995 6 None None None 167646790 Common - NADH-quinone oxidoreductase, F subunit Caul_2828 163 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 167647841 Common - aromatic amino acid beta-eliminating lyase/threonine aldolase Caul_3880 90 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 167645979 Common - Lytic transglycosylase catalytic Caul_2016 99 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 167648923 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase Caul_4968 216 COG0281 SfcA, Malic enzyme Energy production and conversion 167648970 Common - protein of unknown function DUF299 Caul_5015 112 COG1806 COG1806, Uncharacterized protein conserved in bacteria Function unknown 167645290 Nonpathogen - hypothetical protein Caul_1325 1 None None None 167644771 Nonpathogen - hypothetical protein Caul_0805 1 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 167645079 Common - hypothetical protein Caul_1114 11 None None None 167645530 Nonpathogen - hypothetical protein Caul_1565 3 None None None 167645690 Nonpathogen - hypothetical protein Caul_1726 1 None None None 167648715 Common - protein of unknown function DUF167 Caul_4760 10 COG1872 COG1872, Uncharacterized conserved protein Function unknown 167644011 Common - ribosome-binding factor A Caul_0038 52 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 167644555 Common - dehydrogenase E1 component Caul_0587 182 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 167646126 Common - hypothetical protein Caul_2163 28 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 167644678 Nonpathogen - hypothetical protein Caul_0710 2 None None None 167644367 Nonpathogen - hypothetical protein Caul_0395 2 None None None 167647965 Common - glycoside hydrolase family 1 Caul_4005 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 167644778 Common - beta-lactamase Caul_0812 135 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 167648246 Nonpathogen - hypothetical protein Caul_4291 1 None None None 167644359 Common - protein of unknown function DUF952 Caul_0387 39 COG3502 COG3502, Uncharacterized protein conserved in bacteria Function unknown 167646054 Common - general secretion pathway protein G Caul_2091 71 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 167647125 Common - Carbamoyl-phosphate synthase L chain ATP-binding Caul_3163 235 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 167648613 Common - Patatin Caul_4658 11 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 167644014 Common - Polyribonucleotide nucleotidyltransferase Caul_0041 242 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 167644891 Nonpathogen - hypothetical protein Caul_0925 1 None None None 167645070 Common - Integrase catalytic region Caul_1105 146 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 167644576 Common - two component transcriptional regulator, winged helix family Caul_0608 206 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 167646942 Common - nitroreductase Caul_2980 77 COG0778 NfnB, Nitroreductase Energy production and conversion 167648738 Common - hypothetical protein Caul_4783 13 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 167646811 Common - trigger factor Caul_2849 208 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 167645527 Common - hypothetical protein Caul_1562 2 None None None 167644504 Common - hypothetical protein Caul_0535 12 None None None 167644598 Common - two component transcriptional regulator, LuxR family Caul_0630 202 COG4566 TtrR, Response regulator Signal transduction mechanisms 167648785 Common - Alcohol dehydrogenase zinc-binding domain protein Caul_4830 171 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 167647812 Common - protocatechuate 3,4-dioxygenase, alpha subunit Caul_3851 44 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 167645458 Common - rod shape-determining protein RodA Caul_1493 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 167645702 Common - GTP-binding protein Era Caul_1738 221 COG1159 Era, GTPase General function prediction only 167648064 Nonpathogen - hypothetical protein Caul_4105 5 None None None 167648315 Common - folate-binding protein YgfZ Caul_4360 107 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 167646959 Common - phospholipase C, phosphocholine-specific Caul_2997 35 COG3511 PlcC, Phospholipase C Cell envelope biogenesis, outer membrane 167648527 Common - hypothetical protein Caul_4572 48 COG5495 COG5495, Uncharacterized conserved protein Function unknown 167645040 Nonpathogen - putative ferric uptake regulator, Fur family Caul_1075 8 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 167647359 Common - beta-galactosidase Caul_3397 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 167648363 Nonpathogen - hypothetical protein Caul_4408 1 None None None 167646193 Common - domain of unknown function DUF1738 Caul_2231 28 COG4227 COG4227, Antirestriction protein DNA replication, recombination, and repair 167646671 Common - DSBA oxidoreductase Caul_2709 83 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 167644242 Common - transcriptional regulator, AsnC family Caul_0270 149 COG1522 Lrp, Transcriptional regulators Transcription 167644198 Common - TonB-dependent receptor Caul_0226 116 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 167646234 Common - P-type conjugative transfer protein TrbJ Caul_2272 19 COG5314 COG5314, Conjugal transfer/entry exclusion protein Intracellular trafficking and secretion 167646367 Common - hypothetical protein Caul_2405 10 None None None