Rickettsia rickettsii str. Iowa, complete genome NC_010263 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 165933158 Common - acriflavin resistance plasma membrane protein RrIowa_0677 175 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 165933644 Common - hypothetical protein RrIowa_1276 2 None None None 165932778 Common yaeT outer membrane protein assembly factor RrIowa_0250 161 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 165933276 Common - hypothetical protein RrIowa_0821 2 None None None 165933338 Common - hypothetical protein RrIowa_0893 3 None None None 165932802 Common - hypothetical protein RrIowa_0276 1 None None None 165933673 Common - hypothetical protein RrIowa_1316 1 None None None 165933472 Common mgtE Mg2+ transporter RrIowa_1054 160 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 165932576 Pathogen - hypothetical protein RrIowa_0028 1 None None None 165932707 Pathogen - hypothetical protein RrIowa_0171 1 None None None 165933607 Common - hypothetical protein RrIowa_1222 1 None None None 165932941 Pathogen - hypothetical protein RrIowa_0432 1 None None None 165933428 Pathogen - hypothetical protein RrIowa_1005 1 None None None 165933454 Pathogen - hypothetical protein RrIowa_1034 1 None None None 165932673 Common - transporter, drug/metabolite exporter family RrIowa_0136 96 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 165933306 Common - transporter, LysE family RrIowa_0852 81 COG1279 COG1279, Lysine efflux permease General function prediction only 165933548 Common - 10 kDa chaperonin GROES RrIowa_1145 215 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 165933225 Common - ATP-dependent endopeptidase Lon RrIowa_0750 209 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 165933448 Pathogen - hypothetical protein RrIowa_1025 1 None None None 165932786 Common - hypothetical protein RrIowa_0258 199 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 165933042 Pathogen - hypothetical protein RrIowa_0551 1 None None None 165933024 Common - hypothetical membrane associated protein RrIowa_0527 185 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 165932902 Common - protein translation elongation factor P (EF-P) RrIowa_0390 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 165933096 Pathogen - hypothetical protein RrIowa_0611 1 None None None 165933063 Common - NADH-quinone oxidoreductase chain E RrIowa_0575 156 COG1905 NuoE, NADH:ubiquinone oxidoreductase 24 kD subunit Energy production and conversion 165933155 Common - acriflavin resistance plasma membrane protein RrIowa_0674 76 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 165932579 Common - hypothetical protein RrIowa_0032 1 COG2909 MalT, ATP-dependent transcriptional regulator Transcription 165932948 Common lepA.2 GTP-binding protein RrIowa_0443 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 165933258 Common - transcriptional regulator RrIowa_0798 40 COG1396 HipB, Predicted transcriptional regulators Transcription 165932563 Pathogen - hypothetical protein RrIowa_0014 1 None None None 165932607 Common - hypothetical protein RrIowa_0062 8 COG1286 CvpA, Uncharacterized membrane protein, required for colicin V production General function prediction only 165933716 Common - tetrapyrrole (corrin/porphyrin) methylase family protein RrIowa_1365 210 COG0313 COG0313, Predicted methyltransferases General function prediction only 165933639 Common - hypothetical membrane spanning protein RrIowa_1271 1 COG5528 COG5528, Predicted integral membrane protein Function unknown 165932568 Common - hypothetical protein RrIowa_0020 3 None None None 165932836 Common - universal stress protein family RrIowa_0315 42 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 165933781 Common - transcriptional repressor RrIowa_1433 47 COG2944 COG2944, Predicted transcriptional regulator Transcription 165933635 Pathogen - hypothetical protein RrIowa_1267 1 None None None 165932736 Common hflC protease activity modulator RrIowa_0206 214 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 165933352 Pathogen - hypothetical protein RrIowa_0909 1 None None None 165933165 Common - hypothetical protein RrIowa_0688 3 None None None 165933755 Common - peptidoglycan-associated lipoprotein RrIowa_1405 150 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 165932809 Common - thermostable carboxypeptidase 1 RrIowa_0283 82 COG2317 COG2317, Zn-dependent carboxypeptidase Amino acid transport and metabolism 165933339 Pathogen - hypothetical protein RrIowa_0894 1 None None None 165932843 Common - excinuclease ABC subunit B RrIowa_0322 229 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 165933194 Common - acylamino-acid-releasing enzyme RrIowa_0719 121 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 165933841 Common - hypothetical protein RrIowa_1504 10 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 165932728 Common era GTP-binding protein RrIowa_0198 239 COG1159 Era, GTPase General function prediction only 165932618 Common clpB ClpB RrIowa_0079 219 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 165933702 Pathogen - hypothetical protein RrIowa_1351 1 None None None 165933116 Pathogen - hypothetical protein RrIowa_0635 1 None None None 165933144 Common - peptidoglycan-specific endopeptidase, M23 family RrIowa_0663 189 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 165933477 Common - lipoprotein RrIowa_1062 1 None None None 165933283 Common recJ RecJ RrIowa_0828 194 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 165933065 Common - NADH-quinone oxidoreductase chain C RrIowa_0577 168 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 165933078 Common - ABC transporter permease protein RrIowa_0593 46 COG4120 COG4120, ABC-type uncharacterized transport system, permease component General function prediction only 165933132 Common tlpA thiol:disulfide interchange protein RrIowa_0651 126 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 165932624 Common - SSU ribosomal protein S18P RrIowa_0085 208 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 165933600 Common - ATP-dependent RNA helicase RrIowa_1212 242 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 165933868 Common cgtA GTP-binding protein (probably involved in DNA repair) RrIowa_1532 249 COG0536 Obg, Predicted GTPase General function prediction only 165932850 Pathogen - hypothetical protein RrIowa_0333 1 None None None 165933529 Common - SSU ribosomal protein S21P RrIowa_1126 2 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 165933806 Pathogen - hypothetical protein RrIowa_1462 1 None None None 165933237 Common - hypothetical protein RrIowa_0774 2 None None None 165933829 Common - peptidyl-prolyl cis-trans isomerase RrIowa_1492 88 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 165933416 Common - hypothetical protein RrIowa_0980 1 None None None 165933793 Common - ATP synthase beta chain RrIowa_1445 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 165932583 Common - ATP synthase B' chain RrIowa_0036 34 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 165933911 Common - DNA polymerase III, chi subunit RrIowa_1577 17 COG2927 HolC, DNA polymerase III, chi subunit DNA replication, recombination, and repair 165932750 Common - LSU ribosomal protein L10P RrIowa_0221 213 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 165933323 Common - hypothetical protein RrIowa_0874 3 None None None 165933481 Common - cytochrome c-type biogenesis heme chaperone RrIowa_1066 92 COG2332 CcmE, Cytochrome c-type biogenesis protein CcmE Posttranslational modification, protein turnover, chaperones 165933843 Common - heme chaperone heme-lyase RrIowa_1506 109 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 165933436 Common - hypothetical protein RrIowa_1013 1 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 165933724 Common - hypothetical protein RrIowa_1373 1 None None None 165932859 Pathogen - hypothetical protein RrIowa_0344 1 None None None 165933314 Common - Xaa-Pro aminopeptidase RrIowa_0863 214 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 165932997 Pathogen - hypothetical protein RrIowa_0500 1 None None None 165933496 Common - UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase RrIowa_1084 214 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 165933662 Common - thioredoxin peroxidase RrIowa_1301 222 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 165933378 Common - hypothetical protein RrIowa_0936 1 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 165933902 Pathogen - hypothetical protein RrIowa_1568 1 None None None 165932875 Common - hypothetical protein RrIowa_0360 1 None None None 165933506 Pathogen - hypothetical protein RrIowa_1094 1 None None None 165933530 Common - hypothetical protein RrIowa_1127 22 COG5590 COG5590, Uncharacterized conserved protein Function unknown 165933103 Pathogen - hypothetical protein RrIowa_0620 1 None None None 165932784 Common - hypothetical cytosolic protein RrIowa_0256 101 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 165933201 Common recR recombination protein RrIowa_0726 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 165933357 Common - hypothetical protein RrIowa_0914 1 None None None 165933053 Common - hypothetical protein RrIowa_0562 10 None None None 165933397 Common - methyltransferase RrIowa_0960 159 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 165933709 Pathogen - hypothetical protein RrIowa_1358 1 None None None 165932766 Common - aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A RrIowa_0237 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 165933703 Common - lipoic acid synthetase RrIowa_1352 191 COG0320 LipA, Lipoate synthase Coenzyme metabolism 165932989 Common - hypothetical protein RrIowa_0490 2 None None None 165933904 Common relB.3 RelB RrIowa_1570 24 COG2161 StbD, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 165933149 Common - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase RrIowa_0668 212 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 165932812 Common chaB cation transport regulator RrIowa_0286 19 COG4572 ChaB, Putative cation transport regulator General function prediction only 165933101 Common - malate dehydrogenase RrIowa_0618 196 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 165933571 Common - LSU ribosomal protein L18P RrIowa_1181 215 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 165933583 Common - SSU ribosomal protein S19P RrIowa_1193 244 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 165932857 Common - ATPase RrIowa_0342 102 COG1485 COG1485, Predicted ATPase General function prediction only 165932683 Pathogen - hypothetical protein RrIowa_0147 1 None None None 165932881 Pathogen - hypothetical protein RrIowa_0368 1 None None None 165932661 Pathogen - hypothetical protein RrIowa_0124 1 None None None 165933650 Pathogen - hypothetical protein RrIowa_1283 1 None None None 165933467 Common - holo-[acyl-carrier protein] synthase RrIowa_1048 153 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 165933117 Common - hypothetical protein RrIowa_0636 1 None None None 165933414 Common - hypothetical protein RrIowa_0977 7 COG5304 COG5304, Uncharacterized protein conserved in bacteria Function unknown 165933440 Common ftsI cell division protein RrIowa_1017 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 165933245 Pathogen - hypothetical protein RrIowa_0785 1 None None None 165932803 Common - proton/sodium-glutamate symport protein RrIowa_0277 160 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 165933729 Common - transporter, MFS superfamily RrIowa_1378 120 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 165933114 Common - hypothetical protein RrIowa_0633 1 None None None 165933400 Common recO DNA repair protein RrIowa_0963 36 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 165933609 Pathogen - hypothetical protein RrIowa_1224 1 None None None 165933290 Common - hypothetical protein RrIowa_0835 1 None None None 165933385 Common - delta-aminolevulinic acid dehydratase RrIowa_0945 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 165932588 Common - carD-like transcriptional regulator RrIowa_0041 83 COG1329 COG1329, Transcriptional regulators, similar to M. xanthus CarD Transcription 165932651 Common - hypothetical protein RrIowa_0114 1 None None None 165932922 Common - hypothetical protein RrIowa_0410 1 None None None 165933596 Pathogen - hypothetical protein RrIowa_1208 1 None None None 165933460 Pathogen - hypothetical protein RrIowa_1040 1 None None None 165932929 Common lepA.1 GTP-binding protein RrIowa_0420 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 165932980 Pathogen - hypothetical protein RrIowa_0481 1 None None None 165933047 Common capM glycosyltransferase RrIowa_0556 186 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 165932953 Common - proline/betaine transporter RrIowa_0454 23 None None None 165933885 Common - hypothetical protein RrIowa_1551 2 None None None 165933390 Common - 3-polyprenyl-4-hydroxybenzoate decarboxylase RrIowa_0950 152 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 165932794 Common - hypothetical protein RrIowa_0266 6 COG1505 COG1505, Serine proteases of the peptidase family S9A Amino acid transport and metabolism 165933142 Common - hypothetical protein RrIowa_0661 28 None None None 165933722 Common - aspartokinase RrIowa_1371 233 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 165933017 Pathogen - hypothetical protein RrIowa_0520 1 None None None 165933835 Common - methionine aminopeptidase RrIowa_1498 246 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 165933738 Common - multidrug resistance protein B RrIowa_1387 16 None None None 165933263 Pathogen - hypothetical protein RrIowa_0803 1 None None None 165932622 Common phoB phosphate regulon transcriptional regulatory protein RrIowa_0083 5 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 165933808 Common - hypothetical protein RrIowa_1464 4 None None None 165933562 Common - LSU ribosomal protein L17P RrIowa_1172 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 165933183 Common - branched-chain amino acid aminotransferase RrIowa_0708 218 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 165933918 Common nhaA Na+/H+ antiporter RrIowa_1585 104 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 165933537 Pathogen - hypothetical protein RrIowa_1134 1 None None None 165932958 Common - hypothetical protein RrIowa_0459 1 None None None 165932897 Pathogen - pterin-4-alpha-carbinolamine dehydratase RrIowa_0385 1 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 165933665 Common - peptidoglycan-specific endopeptidase, M23 family RrIowa_1304 188 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 165933771 Common ampG.4 AmpG RrIowa_1423 109 None None None 165933026 Common - hypothetical protein RrIowa_0531 1 None None None 165933684 Common - ATP-dependent nuclease subunit A RrIowa_1327 230 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 165932759 Common - hypothetical protein RrIowa_0230 2 None None None 165933456 Common - hypothetical protein RrIowa_1036 1 None None None 165933407 Common - hypothetical protein RrIowa_0970 1 None None None 165933121 Common ampG.1 AmpG RrIowa_0640 109 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 165933858 Common - proline/betaine transporter RrIowa_1521 1 None None None 165932630 Common - succinate dehydrogenase iron-sulfur protein RrIowa_0091 193 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 165932635 Pathogen - hypothetical protein RrIowa_0096 1 None None None 165933871 Common - hypothetical protein RrIowa_1535 1 None None None 165933912 Common - succinyl-diaminopimelate desuccinylase RrIowa_1579 208 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 165933006 Pathogen - hypothetical protein RrIowa_0509 1 None None None 165933922 Common - SSU ribosomal protein S16P RrIowa_1590 209 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 165933341 Common - hypothetical ATPase RrIowa_0896 8 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 165932977 Common - hypothetical protein RrIowa_0478 1 None None None 165933620 Common - hypothetical protein RrIowa_1241 1 None None None 165933853 Common - hypothetical protein RrIowa_1516 1 None None None 165933641 Common - ribosomal-protein-alanine acetyltransferase RrIowa_1273 96 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 165933819 Pathogen - hypothetical protein RrIowa_1481 1 None None None 165933570 Common - SSU ribosomal protein S5P RrIowa_1180 244 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 165933629 Common - LicD protein family RrIowa_1255 14 COG3475 COG3475, LPS biosynthesis protein Cell envelope biogenesis, outer membrane 165933878 Common - glycyl-tRNA synthetase alpha chain RrIowa_1542 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 165933493 Common - phospho-N-acetylmuramoyl-pentapeptide-transferase RrIowa_1081 213 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 165933518 Common - LSU ribosomal protein L34P RrIowa_1111 193 None None None 165933554 Common - proline/betaine transporter RrIowa_1159 1 None None None 165933578 Common - SSU ribosomal protein S17P RrIowa_1188 231 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 165933760 Common ftsY cell division protein RrIowa_1410 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 165933767 Common - DNA polymerase III alpha subunit RrIowa_1419 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 165932729 Common ruvC crossover junction endodeoxyribonuclease RrIowa_0199 198 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 165932900 Common - bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) RrIowa_0388 112 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 165933179 Common - phosphatidate cytidylyltransferase RrIowa_0704 212 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 165932909 Pathogen - hypothetical protein RrIowa_0397 1 None None None 165933348 Pathogen - hypothetical protein RrIowa_0905 1 None None None 165932862 Common - multidrug resistance ABC transporter ATP-binding and permease protein RrIowa_0347 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 165932590 Pathogen - hypothetical protein RrIowa_0043 1 None None None 165933503 Common - hypothetical protein RrIowa_1091 1 None None None 165933618 Common - hypothetical protein RrIowa_1237 144 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 165933426 Common - amidophosphoribosyltransferase family protein RrIowa_1003 2 None None None 165933061 Common - hypothetical protein RrIowa_0573 10 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 165933718 Common tatA Sec-independent protein translocase protein RrIowa_1367 2 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 165933362 Common - transglycosylase SLT family protein RrIowa_0919 45 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 165932839 Common - ferredoxin, 2Fe-2s RrIowa_0318 100 COG0633 Fdx, Ferredoxin Energy production and conversion 165933637 Common - NADH-ubiquinone oxidoreductase 39-40 kDa subunit-like protein RrIowa_1269 1 None None None 165933040 Common - hypothetical protein RrIowa_0549 2 None None None 165933791 Common - aconitate hydratase RrIowa_1443 223 COG1048 AcnA, Aconitase A Energy production and conversion 165932705 Pathogen - hypothetical protein RrIowa_0169 1 None None None 165932561 Pathogen - hypothetical membrane spanning protein RrIowa_0012 1 None None None 165933012 Common - hypothetical protein RrIowa_0515 2 None None None 165933187 Common - succinyl-CoA synthetase alpha chain RrIowa_0712 213 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 165932556 Common - acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase RrIowa_0007 160 COG1043 LpxA, Acyl- acyl carrier protein 165933212 Common - thioredoxin reductase RrIowa_0737 247 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 165933484 Common - hypothetical protein RrIowa_1069 3 None None None 165932592 Common - chlamydia protein associating with death domains RrIowa_0045 10 COG5424 COG5424, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C Coenzyme metabolism 165932834 Pathogen - hypothetical protein RrIowa_0311 1 None None None 165932776 Pathogen - hypothetical protein RrIowa_0247 1 None None None 165933757 Common - 3-oxoacyl-[acyl-carrier-protein] synthase III RrIowa_1407 218 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 165933633 Pathogen - hypothetical protein RrIowa_1261 1 None None None 165932768 Pathogen - hypothetical protein RrIowa_0239 1 COG4997 COG4997, Uncharacterized conserved protein Function unknown 165933419 Pathogen - hypothetical protein RrIowa_0983 1 None None None 165932797 Common - oxygen-independent coproporphyrinogen-III oxidase RrIowa_0271 205 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 165933748 Pathogen - hypothetical protein RrIowa_1397 1 None None None 165932648 Common parA chromosome partitioning protein RrIowa_0111 230 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 165932726 Common - signal peptidase I RrIowa_0196 199 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 165933279 Common - hypothetical protein RrIowa_0824 1 COG5346 COG5346, Predicted membrane protein Function unknown 165933814 Common - hypothetical protein RrIowa_1473 1 None None None 165932761 Common secY.1 stabilizing membrane protein RrIowa_0232 132 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 165932841 Common hscB chaperone protein RrIowa_0320 51 COG1076 DjlA, DnaJ-domain-containing proteins 1 Posttranslational modification, protein turnover, chaperones 165933522 Pathogen - hypothetical protein RrIowa_1115 1 None None None 165933534 Pathogen - hypothetical protein RrIowa_1131 1 None None None 165932887 Common - topoisomerase IV subunit B RrIowa_0374 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 165933421 Common - proline/betaine transporter RrIowa_0987 9 None None None 165933860 Pathogen - hypothetical protein RrIowa_1523 1 None None None 165932823 Common - hypothetical protein RrIowa_0297 9 None None None 165933692 Pathogen - hypothetical protein RrIowa_1339 1 None None None 165933470 Common - DNA gyrase subunit B RrIowa_1051 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 165933084 Common - disulfide bond formation protein B RrIowa_0599 4 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 165933434 Common - hypothetical protein RrIowa_1011 67 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 165932890 Common ybgF Tol system periplasmic component RrIowa_0377 47 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 165932947 Common - bacterial peptide chain release factor 2 (RF-2) RrIowa_0442 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 165933220 Pathogen - hypothetical protein RrIowa_0745 1 None None None 165933675 Common - hypothetical protein RrIowa_1318 1 None None None 165932867 Common relE RelE RrIowa_0352 11 COG4115 COG4115, Uncharacterized protein conserved in bacteria Function unknown 165933766 Pathogen - hypothetical protein RrIowa_1418 1 None None None 165933167 Common - tRNA 2-methylthioadenosine synthase-like protein RrIowa_0692 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 165933508 Common - bicyclomycin resistance protein RrIowa_1096 1 None None None 165933464 Common secA protein translocase subunit RrIowa_1045 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 165933788 Common - NADH-quinone oxidoreductase chain H RrIowa_1440 187 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 165933008 Common - type I secretion adaptor protein (HlyD family) RrIowa_0511 132 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 165933376 Common - hypothetical protein RrIowa_0934 2 None None None 165933739 Pathogen - hypothetical protein RrIowa_1388 1 None None None 165932995 Pathogen - hypothetical protein RrIowa_0496 1 None None None 165932631 Pathogen - hypothetical protein RrIowa_0092 1 None None None 165933355 Common - dihydrolipoamide dehydrogenase RrIowa_0912 247 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 165932602 Common - hypothetical protein RrIowa_0057 1 None None None 165933076 Common - anhydro-N-acetylmuramyl-tripeptide amidase RrIowa_0591 69 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 165933532 Pathogen - hypothetical protein RrIowa_1129 1 None None None 165932730 Common - rRNA methylase, SpoU family RrIowa_0200 155 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 165932782 Common - hypothetical protein RrIowa_0254 2 None None None 165933812 Common bolA.2 BolA RrIowa_1468 47 COG0271 BolA, Stress-induced morphogen (activity unknown) Signal transduction mechanisms 165933611 Common - hypothetical protein RrIowa_1226 8 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 165932914 Common - UDP-N-acetylenolpyruvoylglucosamine reductase RrIowa_0402 205 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 165932551 Common - thioredoxin RrIowa_0002 233 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 165933822 Common - DnaK suppressor protein RrIowa_1485 153 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 165933602 Pathogen - hypothetical protein RrIowa_1215 1 None None None 165933285 Common - transcription termination factor rho RrIowa_0830 206 COG1158 Rho, Transcription termination factor Transcription 165932938 Common - hypothetical protein RrIowa_0429 1 None None None 165933032 Common - membrane protease family, stomatin/prohibitin-like protein RrIowa_0541 216 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 165932629 Common - hypothetical protein RrIowa_0090 23 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 165932558 Common - UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase RrIowa_0009 166 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 165933192 Common - cytochrome b561 RrIowa_0717 1 None None None 165933866 Common - hypothetical protein RrIowa_1530 1 None None None 165933820 Common - bacterial protein translation initiation factor 1 (IF-1) RrIowa_1483 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 165933845 Common - CzcD RrIowa_1508 189 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 165933235 Pathogen - hypothetical protein RrIowa_0766 1 None None None 165932998 Pathogen - hypothetical protein RrIowa_0501 1 None None None 165933160 Common - acriflavin resistance plasma membrane protein RrIowa_0679 3 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 165932572 Common - poly(A) polymerase RrIowa_0024 201 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 165933098 Pathogen - hypothetical protein RrIowa_0613 1 None None None 165932609 Pathogen - hypothetical protein RrIowa_0064 1 None None None 165932581 Common - tetratricopeptide repeat family protein RrIowa_0034 1 None None None 165933876 Common - peptide release factor-glutamine N5-methyltransferase RrIowa_1540 224 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 165932574 Common comA DNA translocation competence protein RrIowa_0026 95 COG0658 ComEC, Predicted membrane metal-binding protein General function prediction only 165932616 Common - acetoacetyl-CoA reductase RrIowa_0073 16 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 165933100 Pathogen - hypothetical protein RrIowa_0617 1 None None None 165933864 Common - 5-aminolevulinic acid synthase RrIowa_1528 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 165932657 Pathogen - hypothetical protein RrIowa_0120 1 None None None 165933034 Common - integral membrane protein RrIowa_0543 69 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 165933045 Common - hypothetical protein RrIowa_0554 2 None None None 165933594 Common - hypothetical protein RrIowa_1206 5 None None None 165933831 Pathogen - outer membrane protein A RrIowa_1494 1 None None None 165932920 Common - hypothetical protein RrIowa_0408 1 None None None 165933373 Common - hypothetical protein RrIowa_0931 1 None None None 165933227 Pathogen - hypothetical protein RrIowa_0754 1 None None None 165932963 Common virB8.1 channel protein RrIowa_0464 6 COG3736 VirB8, Type IV secretory pathway, component VirB8 Intracellular trafficking and secretion 165933368 Common - UDP-N-acetylglucosamine pyrophosphorylase RrIowa_0925 214 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 165933550 Common - ribonuclease PH RrIowa_1155 185 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 165933921 Common - anhydro-N-acetylmuramyl-tripeptide amidase-like protein RrIowa_1588 108 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 165933350 Common - hypothetical membrane spanning protein RrIowa_0907 16 COG1723 COG1723, Uncharacterized conserved protein Function unknown 165933019 Pathogen - hypothetical protein RrIowa_0522 1 None None None 165933720 Common - LSU ribosomal protein L21P RrIowa_1369 208 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 165933528 Pathogen - hypothetical protein RrIowa_1125 1 None None None 165933736 Pathogen - hypothetical protein RrIowa_1385 1 None None None 165932982 Common - ribose 5-phosphate isomerase RrIowa_0483 128 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 165932899 Pathogen - hypothetical protein RrIowa_0387 1 None None None 165933837 Common radC.2 DNA repair protein RrIowa_1500 177 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 165933539 Common - propionyl-CoA carboxylase carboxyltransferase subunit RrIowa_1136 217 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 165932687 Common - 3-deoxy-D-manno-octulosonic-acid transferase RrIowa_0151 128 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 165932642 Common - peptide deformylase RrIowa_0105 212 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 165933668 Common - NAD-dependent DNA ligase RrIowa_1307 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 165932704 Pathogen - hypothetical protein RrIowa_0168 1 None None None 165932681 Common - SSU ribosomal protein S2P RrIowa_0145 230 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 165933466 Common - peptidyl-prolyl cis-trans isomerase RrIowa_1047 161 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 165933552 Common - permease RrIowa_1157 91 COG0628 PerM, Predicted permease General function prediction only 165933119 Common - phospholipid-lipopolysaccharide ABC transporter RrIowa_0638 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 165933581 Common - SSU ribosomal protein S3P RrIowa_1191 242 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 165933588 Common - SSU ribosomal protein S10P RrIowa_1198 232 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 165933107 Common - 3-deoxy-manno-octulosonate cytidylyltransferase RrIowa_0624 137 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 165933292 Pathogen - hypothetical protein RrIowa_0837 1 None None None 165932905 Common - phosphatidylserine decarboxylase RrIowa_0393 95 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 165933541 Common - 2-acylglycerophosphoethanolamine acyltransferase RrIowa_1138 226 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 165933446 Pathogen - hypothetical protein RrIowa_1023 1 None None None 165933010 Common - aspartate-semialdehyde dehydrogenase RrIowa_0513 234 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 165933883 Common - hypothetical protein RrIowa_1549 1 None None None 165933705 Common - carboxylesterase RrIowa_1354 72 COG0400 COG0400, Predicted esterase General function prediction only 165933412 Common - tyrosyl-tRNA synthetase RrIowa_0975 216 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 165933127 Common - hypothetical protein RrIowa_0646 19 None None None 165933268 Common - biotin apo-protein ligase-related protein RrIowa_0810 7 COG4285 COG4285, Uncharacterized conserved protein Function unknown 165933243 Common - hypothetical protein RrIowa_0780 11 None None None 165933402 Common - glycoprotease family protein RrIowa_0965 152 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 165933388 Common - hypothetical protein RrIowa_0948 1 None None None 165933203 Common - hypothetical protein RrIowa_0728 1 None None None 165933680 Common - hypothetical protein RrIowa_1323 45 COG3494 COG3494, Uncharacterized protein conserved in bacteria Function unknown 165933683 Common - cytochrome c oxidase assembly protein Surf1 RrIowa_1326 54 COG3346 COG3346, Uncharacterized conserved protein Function unknown 165933177 Common - ribonuclease D RrIowa_0702 78 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 165933893 Common - NAD(P) transhydrogenase alpha subunit RrIowa_1559 166 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 165933315 Common - amino acid permease RrIowa_0864 191 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 165932877 Common - multidrug resistance ABC transporter ATP-binding and permease protein RrIowa_0362 226 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 165932792 Pathogen - hypothetical protein RrIowa_0264 1 None None None 165933185 Common - SsrA-binding protein RrIowa_0710 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 165932746 Common secE protein translocase subunit RrIowa_0217 2 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 165933022 Common - lipid-A-disaccharide synthase RrIowa_0525 139 COG0763 LpxB, Lipid A disaccharide synthetase Cell envelope biogenesis, outer membrane 165932860 Pathogen - hypothetical protein RrIowa_0345 1 None None None 165932935 Common shaG sodium/proton antiporter protein RrIowa_0426 8 COG1320 MnhG, Multisubunit Na+/H+ antiporter, MnhG subunit Inorganic ion transport and metabolism 165933750 Common - guanylate kinase RrIowa_1399 213 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 165932945 Common - hypothetical protein RrIowa_0438 1 None None None 165933344 Common - muramoyltetrapeptide carboxypeptidase RrIowa_0899 43 COG1619 LdcA, Uncharacterized proteins, homologs of microcin C7 resistance protein MccF Defense mechanisms 165933360 Common - hypothetical protein RrIowa_0917 15 None None None 165933145 Common - lipoprotein signal peptidase RrIowa_0664 195 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 165933677 Common - NADH-ubiquinone oxidoreductase subunit B17.2 like protein RrIowa_1320 33 COG3761 COG3761, NADH:ubiquinone oxidoreductase 17.2 kD subunit Energy production and conversion 165933690 Pathogen - hypothetical protein RrIowa_1333 1 None None None 165933086 Common - transporter RrIowa_0601 70 COG0679 COG0679, Predicted permeases General function prediction only 165932774 Common - hypothetical protein RrIowa_0245 1 None None None 165932913 Common - UDP-N-acetylmuramate--alanine ligase RrIowa_0401 211 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 165932799 Pathogen - hypothetical protein RrIowa_0273 1 None None None 165933251 Common - arabinose-5-phosphate isomerase RrIowa_0791 163 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 165933274 Pathogen - hypothetical protein RrIowa_0819 1 None None None 165932692 Common - SAM-dependent methyltransferase RrIowa_0156 8 None None None 165932869 Common - peptidase, M16 family RrIowa_0354 199 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 165933409 Pathogen - hypothetical protein RrIowa_0972 1 None None None 165933161 Common - acriflavin resistance plasma membrane protein RrIowa_0680 1 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 165933816 Pathogen - outer membrane protein A RrIowa_1475 1 None None None 165933565 Common - SSU ribosomal protein S13P RrIowa_1175 232 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 165933171 Pathogen - molecular chaperones (DnaJ family) RrIowa_0696 2 None None None 165933773 Common - seryl-tRNA synthetase RrIowa_1425 244 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 165933745 Common - 3-oxoacyl-[acyl-carrier-protein] synthase RrIowa_1394 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 165933699 Pathogen - hypothetical protein RrIowa_1348 1 None None None 165932954 Common rodA rod shape-determining protein RrIowa_0455 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 165932637 Common yidC 60 kDa inner membrane protein RrIowa_0098 215 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 165932715 Common virB6.2 channel protein RrIowa_0180 6 COG3704 VirB6, Type IV secretory pathway, VirB6 components Intracellular trafficking and secretion 165933133 Common sppA.1 signal peptide peptidase RrIowa_0652 170 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 165932814 Common dnaK chaperone protein RrIowa_0288 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 165933136 Common - hypothetical protein RrIowa_0655 1 None None None 165933525 Common - hypothetical protein RrIowa_1118 4 None None None 165933331 Common clpP ATP-dependent endopeptidase clp proteolytic subunit RrIowa_0885 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 165933824 Common - hypothetical protein RrIowa_1487 1 None None None 165933520 Common - hypothetical protein RrIowa_1113 1 None None None 165933051 Common - protoheme IX farnesyltransferase RrIowa_0560 165 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 165933847 Common - ATP/GTP binding protein RrIowa_1510 105 COG1881 COG1881, Phospholipid-binding protein General function prediction only 165932825 Pathogen - hypothetical protein RrIowa_0299 1 None None None 165933499 Common - rhodanese-related sulfurtransferase RrIowa_1087 41 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 165933865 Common - hypothetical protein RrIowa_1529 1 None None None 165932936 Common shaA ShaA RrIowa_0427 41 COG1563 COG1563, Predicted subunit of the Multisubunit Na+/H+ antiporter Inorganic ion transport and metabolism 165932703 Pathogen - hypothetical protein RrIowa_0167 1 None None None 165933233 Common - protein U precursor RrIowa_0764 18 COG5430 COG5430, Uncharacterized secreted protein Function unknown 165932599 Pathogen - hypothetical protein RrIowa_0054 1 None None None 165933190 Common - hypothetical protein RrIowa_0715 1 COG5611 COG5611, Predicted nucleic-acid-binding protein, contains PIN domain General function prediction only 165933432 Common - sodium/cholate efflux system protein F RrIowa_1009 1 COG2212 MnhF, Multisubunit Na+/H+ antiporter, MnhF subunit Inorganic ion transport and metabolism 165933379 Common - hypothetical protein RrIowa_0937 1 None None None 165932848 Common - DNA gyrase subunit A RrIowa_0329 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 165932614 Pathogen - hypothetical protein RrIowa_0071 1 None None None 165933614 Common ubiB 2-polyprenylphenol 6-hydroxylase accessory protein RrIowa_1233 184 COG0661 AarF, Predicted unusual protein kinase General function prediction only 165933797 Common - dihydrolipoamide dehydrogenase RrIowa_1449 246 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 165933575 Common - LSU ribosomal protein L5P RrIowa_1185 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 165932754 Common - hypothetical protein RrIowa_0225 1 None None None 165933210 Common - auxin efflux carrier family protein RrIowa_0735 15 COG0679 COG0679, Predicted permeases General function prediction only 165933764 Pathogen - hypothetical protein RrIowa_1416 1 None None None 165932993 Common - ABC transporter ATP-binding protein RrIowa_0494 208 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 165932912 Common - sensory box/GGDEF family protein RrIowa_0400 162 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 165933486 Common recG ATP-dependent DNA helicase RrIowa_1071 234 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 165932628 Common ftsH cell division protein RrIowa_0089 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 165933044 Common - periplasmic component of efflux system RrIowa_0553 145 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 165933204 Pathogen - hypothetical protein RrIowa_0729 1 None None None 165933298 Common - hypothetical protein RrIowa_0844 2 COG5622 COG5622, Protein required for attachment to host cells Cell motility and secretion 165932815 Common degP.2 endopeptidase RrIowa_0289 199 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 165933267 Common - glutathione S-transferase family protein RrIowa_0809 59 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 165932676 Pathogen - hypothetical protein RrIowa_0139 1 None None None 165933444 Common mraZ cell division protein RrIowa_1021 122 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 165933476 Common - hypothetical protein RrIowa_1061 3 COG4710 COG4710, Predicted DNA-binding protein with an HTH domain General function prediction only 165933544 Common - glutamyl-tRNA synthetase RrIowa_1141 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 165933272 Pathogen - hypothetical protein RrIowa_0814 1 None None None 165933106 Common - CTP synthase RrIowa_0623 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 165933411 Common - hemolysin RrIowa_0974 131 COG1189 COG1189, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 165932772 Common shaE sodium/proton antiporter protein RrIowa_0243 18 COG1863 MnhE, Multisubunit Na+/H+ antiporter, MnhE subunit Inorganic ion transport and metabolism 165933770 Common - hypothetical protein RrIowa_1422 14 COG3164 COG3164, Predicted membrane protein Function unknown 165933038 Common - UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose 3,5-epimerase RrIowa_0547 169 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 165932641 Common - hypothetical protein RrIowa_0104 1 None None None 165932584 Common - ATP synthase C chain RrIowa_0037 66 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 165932919 Common - cytochrome c RrIowa_0407 57 COG3474 COG3474, Cytochrome c2 Energy production and conversion 165933287 Common - hypothetical protein RrIowa_0832 11 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 165932892 Common - PQQ enzyme repeat family protein RrIowa_0379 82 COG1520 COG1520, FOG: WD40-like repeat Function unknown 165932570 Common - ATP/GTP hydrolase RrIowa_0022 197 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 165933176 Pathogen - hypothetical protein RrIowa_0701 1 None None None 165932763 Common - FMN reductase RrIowa_0234 126 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 165933404 Common - bacterial protein translation initiation factor 2 (IF-2) RrIowa_0967 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 165933648 Common lolE lipoprotein releasing system transmembrane protein RrIowa_1281 183 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 165933092 Common - hypothetical protein RrIowa_0607 3 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 165932957 Common - virulence-associated protein C RrIowa_0458 17 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 165933712 Pathogen - hypothetical protein RrIowa_1361 1 None None None 165933898 Pathogen - hypothetical protein RrIowa_1564 1 None None None 165932737 Common degP.1 endopeptidase RrIowa_0207 223 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 165932723 Common - hypothetical cytosolic protein RrIowa_0193 37 COG3750 COG3750, Uncharacterized protein conserved in bacteria Function unknown 165933178 Common - septum formation initiator RrIowa_0703 24 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 165933083 Pathogen - hypothetical protein RrIowa_0598 1 None None None 165932894 Common - SSU ribosomal protein S9P RrIowa_0381 219 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 165933058 Common - exodeoxyribonuclease VII small subunit RrIowa_0567 97 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 165932883 Common - type I secretion outer membrane protein RrIowa_0370 115 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 165933275 Common - hypothetical cytosolic protein RrIowa_0820 25 COG5448 COG5448, Uncharacterized conserved protein Function unknown 165933761 Common - DNA polymerase I RrIowa_1411 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 165933676 Common ttg2C toluene transport system protein RrIowa_1319 109 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 165933372 Pathogen - hypothetical protein RrIowa_0930 1 None None None 165933642 Common queC queuosine biosynthesis protein RrIowa_1274 176 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 165933616 Common ubiE ubiquinone/menaquinone biosynthesis methyltransferase RrIowa_1235 217 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 165933217 Pathogen - hypothetical protein RrIowa_0742 1 None None None 165932554 Common - pyridine nucleotide-disulfide oxidoreductase family RrIowa_0005 119 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 165932820 Common - 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase RrIowa_0294 47 COG2941 CAT5, Ubiquinone biosynthesis protein COQ7 Coenzyme metabolism 165932566 Common - hypothetical protein RrIowa_0017 1 None None None 165933256 Common - ADP,ATP carrier protein RrIowa_0796 7 COG3202 COG3202, ATP/ADP translocase Energy production and conversion 165932604 Pathogen - hypothetical protein RrIowa_0059 1 None None None 165933727 Common - hypothetical protein RrIowa_1376 1 None None None 165933383 Common - NADH-quinone oxidoreductase chain N RrIowa_0943 210 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 165933631 Common - RmuC family protein RrIowa_1259 97 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 165933626 Common - transporter RrIowa_1249 116 None None None 165933074 Common - apolipoprotein N-acyltransferase RrIowa_0589 165 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 165933881 Common - hypothetical cytosolic protein RrIowa_1545 67 COG1636 COG1636, Uncharacterized protein conserved in bacteria Function unknown 165933928 Common - tetratricopeptide repeat family protein RrIowa_1596 118 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 165932732 Common - nucleotidyltransferase RrIowa_0202 1 None None None 165933838 Common - putative undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase RrIowa_1501 172 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 165933147 Common - UDP-N-acetylmuramoylalanine--D-glutamate ligase RrIowa_0666 211 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 165933085 Common - class 1 lysyl-tRNA synthetase RrIowa_0600 77 COG1384 LysS, Lysyl-tRNA synthetase (class I) Translation, ribosomal structure and biogenesis 165933568 Common - LSU ribosomal protein L15P RrIowa_1178 80 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 165933752 Common mreC rod shape-determining protein RrIowa_1401 157 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 165933854 Pathogen - hypothetical protein RrIowa_1517 1 None None None 165933567 Common secY.2 protein translocase subunit RrIowa_1177 243 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 165933002 Common tolR TolR RrIowa_0505 140 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 165933810 Common kefC glutathione-regulated potassium-efflux system protein RrIowa_1466 178 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 165933174 Common - hypothetical cytosolic protein RrIowa_0699 17 None None None 165933452 Common - ADA regulatory protein RrIowa_1032 197 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 165932907 Common - multidrug resistance protein A RrIowa_0395 130 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 165933438 Common - PP-loop superfamily ATPase RrIowa_1015 1 None None None 165933137 Common - muramoyltetrapeptide carboxypeptidase RrIowa_0656 81 COG1619 LdcA, Uncharacterized proteins, homologs of microcin C7 resistance protein MccF Defense mechanisms 165933029 Common - DNA topoisomerase I RrIowa_0536 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 165933776 Common - hypothetical protein RrIowa_1428 2 None None None 165932639 Common - hypothetical protein RrIowa_0100 9 None None None 165933206 Pathogen - hypothetical protein RrIowa_0731 1 None None None 165933874 Pathogen - hypothetical protein RrIowa_1538 1 None None None 165933804 Common - tRNA 2-methylthioadenosine synthase RrIowa_1456 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 165932695 Common - ribose-phosphate pyrophosphokinase RrIowa_0159 229 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 165933708 Pathogen - hypothetical protein RrIowa_1357 1 None None None 165932817 Common - hypothetical protein RrIowa_0291 1 None None None 165933742 Common recA RecA RrIowa_1391 244 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 165933254 Common - SSU ribosomal protein S15P RrIowa_0794 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 165933418 Pathogen - hypothetical protein RrIowa_0982 1 None None None 165932808 Common - 2-oxoglutarate dehydrogenase E1 component RrIowa_0282 151 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 165933459 Pathogen - hypothetical protein RrIowa_1039 1 None None None 165932741 Common - succinate dehydrogenase flavoprotein subunit RrIowa_0211 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 165933328 Common - acetyltransferase RrIowa_0879 10 COG0456 RimI, Acetyltransferases General function prediction only 165933249 Pathogen - hypothetical protein RrIowa_0789 1 None None None 165933346 Common resE.2 sensor protein RrIowa_0901 135 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 165933130 Common - protocatechuate 3,4-dioxygenase beta subunit RrIowa_0649 32 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 165933891 Common greA transcription elongation factor RrIowa_1557 204 COG0782 GreA, Transcription elongation factor Transcription 165932594 Common - dihydrofolate reductase RrIowa_0047 103 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 165933514 Common - LSU ribosomal protein L25P RrIowa_1107 185 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 165933295 Common - hypothetical cytosolic protein RrIowa_0840 7 None None None 165933366 Common - LSU ribosomal protein L36P RrIowa_0923 12 None None None 165933546 Pathogen - hypothetical protein RrIowa_1143 1 None None None 165932884 Common - hypothetical protein RrIowa_0371 16 COG3827 COG3827, Uncharacterized protein conserved in bacteria Function unknown 165932966 Common virB9.2 channel protein RrIowa_0467 39 COG3504 VirB9, Type IV secretory pathway, VirB9 components Intracellular trafficking and secretion 165933238 Pathogen - hypothetical protein RrIowa_0775 1 None None None 165933669 Common - queuine tRNA-ribosyltransferase RrIowa_1308 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 165933725 Common romA outer membrane protein RrIowa_1374 35 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 165933731 Common - hypothetical protein RrIowa_1380 1 None None None 165932985 Common thyX thymidylate synthase RrIowa_0486 32 COG1351 THY1, Predicted alternative thymidylate synthase Nucleotide transport and metabolism 165933655 Pathogen - hypothetical protein RrIowa_1292 1 None None None 165933747 Common - hypothetical protein RrIowa_1396 28 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 165932655 Pathogen - hypothetical protein RrIowa_0118 1 None None None 165932972 Pathogen - hypothetical protein RrIowa_0473 1 None None None 165932650 Common - ABC transporter ATP-binding protein RrIowa_0113 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 165933284 Common - methyltransferase RrIowa_0829 26 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 165932852 Pathogen - hypothetical protein RrIowa_0335 1 None None None 165933659 Pathogen - hypothetical protein RrIowa_1298 1 COG0789 SoxR, Predicted transcriptional regulators Transcription 165933693 Pathogen - hypothetical protein RrIowa_1340 1 None None None 165932699 Common - ABC transporter permease protein RrIowa_0163 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 165932926 Common - exodeoxyribonuclease III RrIowa_0417 194 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 165933889 Common - DNA primase RrIowa_1555 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 165933197 Common - hypothetical protein RrIowa_0722 12 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 165932717 Common virB6.4 channel protein RrIowa_0182 21 COG3704 VirB6, Type IV secretory pathway, VirB6 components Intracellular trafficking and secretion 165932805 Common - 6-pyruvoyl tetrahydropterin synthase RrIowa_0279 97 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 165933394 Common - tyrosine-specific transport protein RrIowa_0957 1 None None None 165933020 Pathogen - hypothetical protein RrIowa_0523 1 None None None 165933908 Common - DNA-damage-inducible protein J RrIowa_1574 36 COG3077 RelB, DNA-damage-inducible protein J DNA replication, recombination, and repair 165933067 Common - NADH-quinone oxidoreductase chain A RrIowa_0579 163 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 165932694 Common ttg2D toluene transport system protein RrIowa_0158 43 COG2854 Ttg2D, ABC-type transport system involved in resistance to organic solvents, auxiliary component Secondary metabolites biosynthesis, transport, and catabolism 165933301 Common - alpha/beta hydrolase RrIowa_0847 89 COG2945 COG2945, Predicted hydrolase of the alpha/beta superfamily General function prediction only 165933586 Common - LSU ribosomal protein L1E (= L4P) RrIowa_1196 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 165933430 Common - hypothetical protein RrIowa_1007 1 None None None 165932790 Common - DNA polymerase III, delta' subunit RrIowa_0262 33 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 165933901 Pathogen - hypothetical protein RrIowa_1567 1 None None None 165932752 Common - DNA-directed RNA polymerase beta chain RrIowa_0223 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 165933833 Common ftsK cell division protein RrIowa_1496 198 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 165932668 Common ctrA cell cycle transcriptional regulator RrIowa_0131 221 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 165933126 Common - high-affinity iron permease RrIowa_0645 33 COG0672 FTR1, High-affinity Fe2+/Pb2+ permease Inorganic ion transport and metabolism 165933558 Pathogen - hypothetical protein RrIowa_1165 1 None None None 165933784 Common - NADH-quinone oxidoreductase chain L RrIowa_1436 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 165933468 Common - DNA-directed RNA polymerase omega chain RrIowa_1049 53 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 165933660 Common - integration host factor alpha-subunit RrIowa_1299 91 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 165933502 Pathogen - hypothetical protein RrIowa_1090 1 None None None 165933088 Common - hypothetical protein RrIowa_0603 1 None None None 165933896 Common - hypothetical transcriptional regulatory protein RrIowa_1562 148 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 165933399 Common - hypothetical protein RrIowa_0962 2 None None None 165933280 Common - bacterial protein translation initiation factor 3 (IF-3) RrIowa_0825 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 165933851 Pathogen - hypothetical protein RrIowa_1514 1 None None None 165933678 Common - ribonuclease HI RrIowa_1321 175 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 165932679 Common - hypothetical protein RrIowa_0143 4 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 165932795 Pathogen - hypothetical protein RrIowa_0267 1 COG1505 COG1505, Serine proteases of the peptidase family S9A Amino acid transport and metabolism 165932910 Common - hypothetical protein RrIowa_0398 1 None None None 165933036 Common - virulence-associated protein I RrIowa_0545 11 COG3093 VapI, Plasmid maintenance system antidote protein General function prediction only 165932991 Common - amino acid permease RrIowa_0492 189 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 165932612 Pathogen - hypothetical protein RrIowa_0067 1 None None None 165933495 Pathogen - hypothetical protein RrIowa_1083 1 None None None 165933359 Pathogen - hypothetical protein RrIowa_0916 1 None None None 165933461 Common - hypothetical protein RrIowa_1042 5 None None None 165933743 Common - 3-oxoacyl-[acyl-carrier protein] reductase RrIowa_1392 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 165932870 Common - phosphoribosylamidoimidazole-succinocarboxamide synthase RrIowa_0355 144 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 165933141 Common - cytochrome c oxidase polypeptide I RrIowa_0660 170 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 165932975 Common - hypothetical protein RrIowa_0476 2 COG4695 COG4695, Phage-related protein Function unknown 165933072 Common - hypothetical protein RrIowa_0587 1 None None None 165933325 Common - hypothetical cytosolic protein RrIowa_0876 1 None None None 165933091 Common - hypothetical protein RrIowa_0606 9 COG4374 COG4374, Uncharacterized protein conserved in bacteria Function unknown 165933333 Common - cytidylate kinase RrIowa_0887 205 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 165933697 Common - ADP,ATP carrier protein RrIowa_1346 6 COG3202 COG3202, ATP/ADP translocase Energy production and conversion 165932552 Common - O-antigen export system ATP-binding protein RrIowa_0003 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 165933826 Pathogen - hypothetical protein RrIowa_1489 1 COG3243 PhaC, Poly(3-hydroxyalkanoate) synthetase Lipid metabolism 165932996 Pathogen - hypothetical cytosolic protein RrIowa_0497 1 None None None 165933905 Common - hypothetical protein RrIowa_1571 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 165933925 Common - hypothetical protein RrIowa_1593 1 COG4391 COG4391, Uncharacterized protein conserved in bacteria Function unknown 165932879 Pathogen - hypothetical protein RrIowa_0366 1 None None None 165933538 Common - propionyl-CoA carboxylase biotin-containing subunit RrIowa_1135 240 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 165932643 Common - ADP,ATP carrier protein RrIowa_0106 6 COG3202 COG3202, ATP/ADP translocase Energy production and conversion 165933389 Common - primosomal protein N' RrIowa_0949 213 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 165933163 Pathogen - hypothetical protein RrIowa_0686 1 None None None 165933231 Common - ferredoxin--NAD(P)(+) reductase RrIowa_0762 247 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 165933189 Common - hypothetical protein RrIowa_0714 1 COG5611 COG5611, Predicted nucleic-acid-binding protein, contains PIN domain General function prediction only 165933509 Pathogen - hypothetical protein RrIowa_1100 1 None None None 165933863 Common htpG chaperone protein RrIowa_1527 150 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 165932988 Common ctaG cytochrome c oxidase assembly protein RrIowa_0489 68 COG3175 COX11, Cytochrome oxidase assembly factor Posttranslational modification, protein turnover, chaperones 165933612 Pathogen - hypothetical protein RrIowa_1231 1 None None None 165933849 Pathogen - hypothetical protein RrIowa_1512 1 None None None 165933914 Pathogen - hypothetical protein RrIowa_1581 1 None None None 165932930 Pathogen - hypothetical protein RrIowa_0421 1 None None None 165933153 Pathogen - hypothetical protein RrIowa_0672 1 None None None 165932781 Common - 23S rRNA Um2552 2'-O-methyltransferase RrIowa_0253 138 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 165933289 Pathogen - hypothetical protein RrIowa_0834 1 None None None 165933218 Common - hypothetical protein RrIowa_0743 202 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 165933223 Common - hypothetical protein RrIowa_0748 3 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 165933016 Pathogen - hypothetical protein RrIowa_0519 1 None None None 165932827 Common - hypothetical protein RrIowa_0301 1 None None None 165932743 Common - SSU ribosomal protein S12P RrIowa_0213 242 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 165932701 Common - ABC transporter ATP-binding protein RrIowa_0165 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 165933304 Common - hypothetical protein RrIowa_0850 1 None None None 165933424 Pathogen - hypothetical protein RrIowa_0990 1 None None None 165933081 Pathogen - hypothetical protein RrIowa_0596 1 None None None 165932788 Common - acriflavin resistance plasma membrane protein RrIowa_0260 178 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 165933312 Common - hypothetical protein RrIowa_0858 2 None None None 165933056 Common rimM 16S rRNA processing protein RrIowa_0565 143 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 165933647 Common - multidrug resistance transporter, Bcr family RrIowa_1280 154 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 165932564 Pathogen - hypothetical protein RrIowa_0015 1 None None None 165933182 Common ompR transcriptional regulatory protein RrIowa_0707 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 165933308 Common ampG.2 AmpG RrIowa_0854 100 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 165933818 Pathogen - hypothetical protein RrIowa_1480 1 None None None 165932721 Common - tRNA (guanine-N(1)-)-methyltransferase RrIowa_0191 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 165933354 Pathogen - hypothetical protein RrIowa_0911 1 None None None 165933714 Common - hypothetical protein RrIowa_1363 16 None None None 165933070 Common - integrase/recombinase (XerD/RipX family) RrIowa_0585 227 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 165932901 Common - GGDEF family protein RrIowa_0389 216 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 165933215 Pathogen - hypothetical protein RrIowa_0740 1 None None None 165933265 Common - hypothetical protein RrIowa_0807 1 None None None 165932969 Common virD4 protein virD4 RrIowa_0470 73 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 165932765 Common - aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B RrIowa_0236 213 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 165932606 Common algH transcriptional regulator RrIowa_0061 124 COG1678 COG1678, Putative transcriptional regulator Transcription 165933270 Common - dihydrofolate synthase RrIowa_0812 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 165933336 Pathogen - hypothetical protein RrIowa_0891 1 None None None 165932678 Pathogen - hypothetical protein RrIowa_0142 1 None None None 165932700 Pathogen - hypothetical protein RrIowa_0164 1 None None None 165933779 Common - methyltransferase RrIowa_1431 43 COG4797 COG4797, Predicted regulatory domain of a methyltransferase General function prediction only 165932770 Common - ribosome recycling factor (RRF) RrIowa_0241 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 165933640 Common - ATP-dependent endopeptidase clp ATP-binding subunit RrIowa_1272 231 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 165933027 Pathogen - hypothetical protein RrIowa_0534 1 None None None 165932838 Common - hypothetical protein RrIowa_0317 2 None None None 165932888 Common - carboxy-terminal processing protease precursor RrIowa_0375 183 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 165932711 Common - acetylglutamate kinase RrIowa_0176 152 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 165933474 Common - guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase RrIowa_1056 195 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 165933671 Common - proline/betaine transporter RrIowa_1312 1 None None None 165933516 Common - LSU ribosomal protein L35P RrIowa_1109 105 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 165932767 Common - aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C RrIowa_0238 95 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 165933054 Pathogen - hypothetical protein RrIowa_0563 1 None None None 165932739 Common - succinate dehydrogenase cytochrome b556 subunit RrIowa_0209 68 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 165933240 Common - hypothetical protein RrIowa_0777 1 None None None 165933297 Common - 1-acyl-sn-glycerol-3-phosphate acyltransferase RrIowa_0843 159 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 165933450 Common - hypothetical protein RrIowa_1027 40 COG2847 COG2847, Uncharacterized protein conserved in bacteria Function unknown 165933340 Pathogen - hypothetical protein RrIowa_0895 1 None None None 165933802 Common - beta-lactamase RrIowa_1454 13 COG2602 COG2602, Beta-lactamase class D Defense mechanisms 165933689 Pathogen - hypothetical protein RrIowa_1332 1 None None None 165933208 Common - metal-dependent hydrolase RrIowa_0733 151 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 165933457 Pathogen - hypothetical protein RrIowa_1037 1 None None None 165933695 Pathogen - poly-beta-hydroxybutyrate polymerase RrIowa_1344 1 None None None 165932951 Common - hypothetical protein RrIowa_0450 1 None None None 165933319 Common - cysteine desulfurase RrIowa_0868 240 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 165932819 Common - DNA polymerase III, delta subunit RrIowa_0293 27 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 165932979 Common - 3'(2'),5'-bisphosphate nucleotidase RrIowa_0480 190 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 165933624 Common - methionyl-tRNA synthetase RrIowa_1247 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 165932697 Common - hypothetical protein RrIowa_0161 1 None None None 165933480 Common - cytochrome c oxidase Cu(A) center assembly protein RrIowa_1065 109 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 165933364 Pathogen - hypothetical protein RrIowa_0921 1 None None None 165932810 Common recN DNA repair protein RrIowa_0284 220 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 165933801 Common - beta-lactamase OXA-18 precursor RrIowa_1453 8 COG2602 COG2602, Beta-lactamase class D Defense mechanisms 165932949 Pathogen - hypothetical protein RrIowa_0445 1 None None None 165933926 Common - D-beta-hydroxybutyrate dehydrogenase RrIowa_1594 117 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 165932987 Common - RNA polymerase sigma-32 factor RrIowa_0488 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 165933754 Common - hypothetical membrane spanning protein RrIowa_1403 52 COG0795 COG0795, Predicted permeases General function prediction only 165932822 Common - hypothetical protein RrIowa_0296 1 COG3838 VirB2, Type IV secretory pathway, VirB2 components (pilins) Intracellular trafficking and secretion 165932663 Common - topoisomerase IV subunit A RrIowa_0126 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 165933576 Common - LSU ribosomal protein L24P RrIowa_1186 208 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 165933031 Common - thioredoxin peroxidase RrIowa_0540 223 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 165933429 Common - hypothetical protein RrIowa_1006 1 None None None 165932865 Common - cyanide-insensitive cytochrome bd-type quinol oxidase subunit II RrIowa_0350 149 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 165933856 Common - single-strand DNA binding protein RrIowa_1519 199 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 165933094 Pathogen - hypothetical protein RrIowa_0609 1 None None None 165933778 Common - heat resistant agglutinin RrIowa_1430 2 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 165933622 Pathogen - hypothetical protein RrIowa_1245 1 None None None 165933139 Pathogen - hypothetical protein RrIowa_0658 1 None None None 165933723 Common - hypothetical protein RrIowa_1372 1 None None None 165933749 Common - hypothetical ATPase RrIowa_1398 54 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 165932916 Common ftsQ cell division protein RrIowa_0404 53 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 165933524 Common corA magnesium and cobalt transport protein RrIowa_1117 164 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 165933536 Pathogen - hypothetical protein RrIowa_1133 1 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 165933931 Common - hypothetical membrane spanning protein RrIowa_1602 97 COG1981 COG1981, Predicted membrane protein Function unknown 165933795 Common - ATP synthase alpha chain RrIowa_1447 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 165933887 Common - tRNA pseudouridine synthase A RrIowa_1553 232 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 165933049 Pathogen - hypothetical protein RrIowa_0558 1 None None None 165933392 Common - replicative DNA helicase RrIowa_0952 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 165933382 Pathogen - hypothetical ATP-binding protein RrIowa_0942 1 None None None 165932924 Common - heme O monooxygenase (ferredoxin) RrIowa_0412 45 COG1612 CtaA, Uncharacterized protein required for cytochrome oxidase assembly Posttranslational modification, protein turnover, chaperones 165933166 Common - diaminopimelate epimerase RrIowa_0691 197 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 165933906 Common - metal-dependent hydrolase RrIowa_1572 92 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 165932932 Pathogen - hypothetical protein RrIowa_0423 1 None None None 165933014 Common hslV ATP-dependent endopeptidase hsl proteolytic subunit RrIowa_0517 150 COG5405 HslV, ATP-dependent protease HslVU (ClpYQ), peptidase subunit Posttranslational modification, protein turnover, chaperones 165933598 Common - mitochondrial-type Fe-S cluster assembly protein NFU RrIowa_1210 100 COG0694 COG0694, Thioredoxin-like proteins and domains Posttranslational modification, protein turnover, chaperones 165932596 Common - hypothetical protein RrIowa_0051 2 None None None 165932757 Pathogen - hypothetical protein RrIowa_0228 1 None None None 165933584 Common - LSU ribosomal protein L2P RrIowa_1194 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 165933556 Pathogen - hypothetical protein RrIowa_1163 1 None None None 165932666 Common - deoxycytidine triphosphate deaminase RrIowa_0129 149 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 165932686 Pathogen - hypothetical protein RrIowa_0150 1 None None None 165932964 Common virB7 channel protein RrIowa_0465 1 None None None 165933591 Common - hypothetical protein RrIowa_1203 1 None None None 165933667 Pathogen - hypothetical protein RrIowa_1306 1 None None None 165932942 Common - cytochrome c1 RrIowa_0433 80 COG2857 CYT1, Cytochrome c1 Energy production and conversion 165933247 Common - ABC transporter ATP-binding protein RrIowa_0787 249 COG1137 YhbG, ABC-type (unclassified) transport system, ATPase component General function prediction only 165933657 Common gidB hypothetical protein RrIowa_1296 205 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 165933653 Common - heme chaperone--apocytochrome heme-lyase RrIowa_1286 132 COG1138 CcmF, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 165933199 Common - hypothetical protein RrIowa_0724 5 COG1238 COG1238, Predicted membrane protein Function unknown 165933561 Common - SSU ribosomal protein S20P RrIowa_1171 147 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 165932854 Common - methionyl-tRNA formyltransferase RrIowa_0337 219 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 165932659 Common - deoxyguanosinetriphosphate triphosphohydrolase RrIowa_0122 163 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 165932654 Pathogen - hypothetical protein RrIowa_0117 1 None None None 165933123 Common - lipoprotein RrIowa_0642 136 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 165932872 Common - threonyl-tRNA synthetase RrIowa_0357 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 165933004 Pathogen - hypothetical protein RrIowa_0507 1 None None None 165933111 Common - GTP cyclohydrolase I RrIowa_0630 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 165933605 Common - organic solvent tolerance protein RrIowa_1218 87 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 165933555 Pathogen - proline/betaine transporter RrIowa_1160 1 None None None 165933415 Common - hypothetical protein RrIowa_0978 1 None None None 165932580 Pathogen - hypothetical protein RrIowa_0033 1 None None None 165933721 Common - LSU ribosomal protein L27P RrIowa_1370 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 165932652 Common - 2-dehydro-3-deoxyphosphooctonate aldolase RrIowa_0115 185 COG2877 KdsA, 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase Cell envelope biogenesis, outer membrane 165932638 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase RrIowa_0099 205 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 165933291 Common - hypothetical cytosolic protein RrIowa_0836 84 COG3022 COG3022, Uncharacterized protein conserved in bacteria Function unknown 165933128 Pathogen - hypothetical protein RrIowa_0647 1 None None None 165933296 Common - tryptophanyl-tRNA synthetase RrIowa_0842 230 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 165932889 Common - sensory transduction protein kinase RrIowa_0376 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 165933704 Common - serine hydroxymethyltransferase RrIowa_1353 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 165933809 Common - hypothetical protein RrIowa_1465 43 COG3807 COG3807, Uncharacterized protein conserved in bacteria Function unknown 165932863 Common - hypothetical protein RrIowa_0348 1 None None None 165933872 Common - uracil DNA glycosylase superfamily protein RrIowa_1536 154 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 165932856 Common - hypothetical protein RrIowa_0341 9 COG4421 COG4421, Capsular polysaccharide biosynthesis protein Carbohydrate transport and metabolism 165933172 Pathogen - molecular chaperones (DnaJ family) RrIowa_0697 1 COG4728 COG4728, Uncharacterized protein conserved in bacteria Function unknown 165933834 Common - hypothetical protein RrIowa_1497 6 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 165933018 Common chlI ChlI RrIowa_0521 181 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 165933730 Common - hypothetical protein RrIowa_1379 1 COG3027 COG3027, Uncharacterized protein conserved in bacteria Function unknown 165933244 Common - tRNA delta(2)-isopentenylpyrophosphate transferase RrIowa_0784 214 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 165933884 Common - hypothetical protein RrIowa_1550 1 None None None 165933828 Common - 3-polyprenyl-4-hydroxybenzoate decarboxylase RrIowa_1491 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 165933131 Pathogen - hypothetical protein RrIowa_0650 1 None None None 165933184 Common - dihydrodipicolinate synthase RrIowa_0709 234 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 165932621 Common - acyl-CoA desaturase RrIowa_0082 67 COG1398 OLE1, Fatty-acid desaturase Lipid metabolism 165932844 Common - glutaredoxin RrIowa_0323 113 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 165933595 Common ftsZ cell division protein RrIowa_1207 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 165932617 Pathogen - hypothetical protein RrIowa_0074 1 None None None 165932928 Common - pyruvate dehydrogenase E1 component beta subunit RrIowa_0419 217 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 165932923 Common - ribonuclease E RrIowa_0411 184 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 165932981 Common mutS DNA mismatch repair protein RrIowa_0482 201 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 165932811 Common - lipoprotein, ComL family RrIowa_0285 120 COG4105 ComL, DNA uptake lipoprotein General function prediction only 165933023 Common - hypothetical protein RrIowa_0526 1 None None None 165933143 Common - cytochrome c oxidase polypeptide II RrIowa_0662 155 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 165932689 Common - aspartate aminotransferase RrIowa_0153 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 165932664 Pathogen - hypothetical protein RrIowa_0127 1 None None None 165932632 Pathogen - hypothetical protein RrIowa_0093 1 None None None 165932933 Common - hypothetical protein RrIowa_0424 16 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 165933746 Common - ABC transporter ATP-binding protein uup RrIowa_1395 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 165932793 Common - prolyl endopeptidase family RrIowa_0265 98 COG1505 COG1505, Serine proteases of the peptidase family S9A Amino acid transport and metabolism 165933406 Common - hypothetical cytosolic protein RrIowa_0969 156 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 165933698 Common - phosphohydrolase (MutT/nudix family protein) RrIowa_1347 22 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 165932976 Common - phage host specificity protein RrIowa_0477 2 None None None 165933913 Common - type I restriction-modification system specificity subunit RrIowa_1580 14 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 165933441 Pathogen - hypothetical protein RrIowa_1018 1 None None None 165933580 Common - LSU ribosomal protein L16P RrIowa_1190 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 165932591 Common recF DNA replication and repair protein RrIowa_0044 164 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 165933564 Common - SSU ribosomal protein S11P RrIowa_1174 247 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 165933772 Common tatC Sec-independent protein translocase protein RrIowa_1424 204 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 165932959 Common shaA sodium/proton antiporter protein RrIowa_0460 208 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 165933250 Common - hypothetical protein RrIowa_0790 1 COG5375 COG5375, Uncharacterized protein conserved in bacteria Function unknown 165933563 Common - DNA-directed RNA polymerase alpha chain RrIowa_1173 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 165932896 Pathogen - D-alanyl-D-alanine dipeptidase RrIowa_0384 1 None None None 165933547 Common - 60 kDa chaperonin GROEL RrIowa_1144 236 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 165933025 Common - frataxin family protein RrIowa_0528 31 COG1965 CyaY, Protein implicated in iron transport, frataxin homolog Inorganic ion transport and metabolism 165932868 Common - beta 1,4 glucosyltransferase RrIowa_0353 112 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 165933859 Common - lysozyme RrIowa_1522 11 COG3772 COG3772, Phage-related lysozyme (muraminidase) General function prediction only 165933449 Common - excinuclease ABC subunit C RrIowa_1026 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 165932669 Common queF queuosine biosynthesis protein RrIowa_0132 74 COG2904 COG2904, Uncharacterized protein conserved in bacteria Function unknown 165932684 Pathogen - hypothetical protein RrIowa_0148 1 None None None 165933504 Pathogen - hypothetical protein RrIowa_1092 1 None None None 165933579 Common - LSU ribosomal protein L29P RrIowa_1189 1 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 165933316 Pathogen - lysozyme RrIowa_0865 1 None None None 165933758 Common - LSU ribosomal protein L32P RrIowa_1408 85 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 165933517 Common - LSU ribosomal protein L20P RrIowa_1110 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 165932756 Common - ATPases involved in chromosome partitioning RrIowa_0227 67 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 165933923 Common - LSU ribosomal protein L33P RrIowa_1591 124 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 165933387 Pathogen - hypothetical protein RrIowa_0947 1 None None None 165933768 Common - UDP-glucose 6-dehydrogenase RrIowa_1420 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 165932619 Pathogen - hypothetical protein RrIowa_0080 1 None None None 165933510 Common - hypothetical protein RrIowa_1101 1 None None None 165933664 Common - tetraacyldisaccharide 4'-kinase RrIowa_1303 130 COG1663 LpxK, Tetraacyldisaccharide-1-P 4'-kinase Cell envelope biogenesis, outer membrane 165933621 Common - hypothetical protein RrIowa_1244 1 None None None 165932745 Common - protein translation elongation factor G (EF-G) RrIowa_0215 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 165933241 Common - hypothetical protein RrIowa_0778 1 None None None 165933109 Common - hypothetical protein RrIowa_0628 1 None None None 165933852 Common - hypothetical protein RrIowa_1515 1 None None None 165933361 Common - hypothetical protein RrIowa_0918 1 None None None 165933492 Common rickA Arp2/3 complex activation protein RrIowa_1080 23 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 165933455 Pathogen - hypothetical protein RrIowa_1035 1 None None None 165932691 Common relB.1 RelB RrIowa_0155 5 COG2161 StbD, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 165932908 Pathogen - hypothetical protein RrIowa_0396 1 None None None 165933687 Common - malonyl-CoA-[acyl-carrier-protein] transacylase RrIowa_1330 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 165933879 Common stbB plasmid stability protein RrIowa_1543 40 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 165933041 Common - methyltransferase RrIowa_0550 25 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 165933048 Pathogen - hypothetical protein RrIowa_0557 1 None None None 165932962 Common virB9.1 channel protein RrIowa_0463 56 COG3504 VirB9, Type IV secretory pathway, VirB9 components Intracellular trafficking and secretion 165933471 Common - hydrolase (HAD superfamily) RrIowa_1052 54 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 165933277 Common - phage protein RrIowa_0822 11 COG5449 COG5449, Uncharacterized conserved protein Function unknown 165932824 Common - 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase RrIowa_0298 143 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 165932706 Pathogen - hypothetical protein RrIowa_0170 1 None None None 165932940 Common - cytochrome b RrIowa_0431 149 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 165933756 Common - hypothetical cytosolic protein RrIowa_1406 1 None None None 165933213 Pathogen - hypothetical protein RrIowa_0738 1 None None None 165933347 Pathogen - hypothetical protein RrIowa_0904 1 None None None 165933427 Common - hypothetical protein RrIowa_1004 1 None None None 165933150 Common - hypothetical protein RrIowa_0669 1 None None None 165933278 Common - hypothetical protein RrIowa_0823 1 None None None 165933494 Common - UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase RrIowa_1082 210 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 165932801 Common - hypothetical protein RrIowa_0275 1 None None None 165933610 Common - GTP-binding protein RrIowa_1225 232 COG1160 COG1160, Predicted GTPases General function prediction only 165933090 Pathogen - hypothetical protein RrIowa_0605 1 None None None 165933326 Common - hypothetical protein RrIowa_0877 1 None None None 165933398 Common radA DNA repair protein RrIowa_0961 208 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 165933089 Pathogen ralF protein transport protein SEC7 RrIowa_0604 1 None None None 165932779 Common - membrane endopeptidase, M50 family RrIowa_0251 209 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 165932560 Common - hypothetical membrane associated protein RrIowa_0011 3 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 165933590 Common - 23S rRNA Gm2251 methyltransferase RrIowa_1202 215 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 165933259 Common - ribonuclease BN RrIowa_0799 89 COG1295 Rbn, Predicted membrane protein Function unknown 165933064 Common - NADH-quinone oxidoreductase chain D RrIowa_0576 191 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 165933850 Common - hypothetical protein RrIowa_1513 1 None None None 165932829 Pathogen - hypothetical protein RrIowa_0303 1 None None None 165932733 Common - hypothetical protein RrIowa_0203 23 COG3660 COG3660, Predicted nucleoside-diphosphate-sugar epimerase Cell envelope biogenesis, outer membrane 165932833 Pathogen - hypothetical protein RrIowa_0310 1 None None None 165933380 Pathogen - hypothetical protein RrIowa_0938 1 None None None 165933672 Common - hypothetical protein RrIowa_1315 1 None None None 165932647 Common - methyltransferase RrIowa_0110 181 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 165932769 Pathogen - hypothetical protein RrIowa_0240 1 None None None 165933608 Common - exodeoxyribonuclease III RrIowa_1223 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 165933422 Pathogen - hypothetical protein RrIowa_0988 1 None None None 165933309 Common - hypothetical cytosolic protein RrIowa_0855 1 None None None 165933634 Common - hypothetical protein RrIowa_1262 1 None None None 165932569 Pathogen - hypothetical protein RrIowa_0021 1 None None None 165933638 Common - hypothetical membrane spanning protein RrIowa_1270 1 None None None 165933305 Common - uroporphyrinogen-III synthase RrIowa_0851 2 None None None 165932787 Common - hypothetical protein RrIowa_0259 14 COG2155 COG2155, Uncharacterized conserved protein Function unknown 165932690 Pathogen - hypothetical protein RrIowa_0154 1 None None None 165932672 Common - hypothetical protein RrIowa_0135 8 COG3047 OmpW, Outer membrane protein W Cell envelope biogenesis, outer membrane 165932720 Pathogen - hypothetical protein RrIowa_0190 1 None None None 165933540 Pathogen - hypothetical protein RrIowa_1137 1 None None None 165933521 Pathogen - hypothetical protein RrIowa_1114 1 None None None 165933097 Pathogen - hypothetical protein RrIowa_0612 1 None None None 165932578 Pathogen - hypothetical protein RrIowa_0031 1 None None None 165932903 Common - myo-inositol-1(or 4)-monophosphatase RrIowa_0391 140 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 165933062 Common - hypothetical cytosolic protein RrIowa_0574 188 COG0759 COG0759, Uncharacterized conserved protein Function unknown 165933794 Common - ATP synthase gamma chain RrIowa_1446 206 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 165932608 Pathogen - hypothetical protein RrIowa_0063 1 None None None 165933861 Common - hypothetical protein RrIowa_1524 1 None None None 165933370 Pathogen - hypothetical protein RrIowa_0928 1 None None None 165933601 Common - cold shock protein RrIowa_1213 174 COG1278 CspC, Cold shock proteins Transcription 165933079 Common - ABC transporter ATP-binding protein RrIowa_0594 249 COG1101 PhnK, ABC-type uncharacterized transport system, ATPase component General function prediction only 165932952 Common - guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase RrIowa_0453 202 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 165933288 Pathogen - hypothetical protein RrIowa_0833 1 None None None 165933842 Common - ferredoxin RrIowa_1505 165 COG1146 COG1146, Ferredoxin Energy production and conversion 165933919 Common - hypothetical protein RrIowa_1586 10 COG1434 COG1434, Uncharacterized conserved protein Function unknown 165933236 Common - protein U precursor RrIowa_0773 3 COG5430 COG5430, Uncharacterized secreted protein Function unknown 165932846 Pathogen - multidrug resistance ABC transporter ATP-binding and permease protein RrIowa_0327 1 None None None 165932874 Common - hypothetical protein RrIowa_0359 1 None None None 165933195 Common - hypothetical protein RrIowa_0720 7 COG4395 COG4395, Uncharacterized protein conserved in bacteria Function unknown 165932550 Common - ATP/GTP-binding protein RrIowa_0001 112 COG1806 COG1806, Uncharacterized protein conserved in bacteria Function unknown 165933869 Common - citrate synthase RrIowa_1533 193 COG0372 GltA, Citrate synthase Energy production and conversion 165933877 Common - glycyl-tRNA synthetase beta chain RrIowa_1541 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 165933799 Pathogen - hypothetical protein RrIowa_1451 1 None None None 165933894 Common - hypothetical protein RrIowa_1560 9 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 165933910 Common - hypothetical protein RrIowa_1576 40 COG0795 COG0795, Predicted permeases General function prediction only 165933840 Common - hypothetical protein RrIowa_1503 1 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 165932851 Common - hypothetical protein RrIowa_0334 2 None None None 165933487 Pathogen - hypothetical protein RrIowa_1075 1 None None None 165933052 Common - spore photoproduct lyase RrIowa_0561 17 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 165932582 Common - ATP synthase B chain RrIowa_0035 3 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 165933482 Common - inorganic pyrophosphatase RrIowa_1067 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 165933701 Common - hypothetical metal-binding protein RrIowa_1350 113 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 165932785 Common - hypothetical cytosolic protein RrIowa_0257 3 COG5508 COG5508, Uncharacterized conserved small protein Function unknown 165933102 Pathogen - hypothetical protein RrIowa_0619 1 None None None 165932640 Common - hypothetical protein RrIowa_0101 2 None None None 165933903 Pathogen - hypothetical protein RrIowa_1569 1 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 165933515 Common queE queuosine biosynthesis protein RrIowa_1108 170 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 165933035 Common - hypothetical cytosolic protein RrIowa_0544 189 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 165933157 Common - acriflavin resistance plasma membrane protein RrIowa_0676 66 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 165933435 Pathogen - hypothetical protein RrIowa_1012 1 None None None 165932601 Common - hypothetical protein RrIowa_0056 1 None None None 165932921 Common - UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase RrIowa_0409 139 COG0774 LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase Cell envelope biogenesis, outer membrane 165933377 Common - hypothetical protein RrIowa_0935 1 None None None 165933168 Common - phenylalanyl-tRNA synthetase alpha chain RrIowa_0693 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 165932915 Common - D-alanine--D-alanine ligase RrIowa_0403 212 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 165933780 Pathogen - hypothetical protein RrIowa_1432 1 None None None 165933663 Common - lipid A biosynthesis lauroyl acyltransferase RrIowa_1302 116 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 165933789 Common - NADH-quinone oxidoreductase chain G RrIowa_1441 190 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 165932751 Common - LSU ribosomal protein L12P (L7/L12) RrIowa_0222 213 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 165933505 Common - hypothetical protein RrIowa_1093 1 None None None 165933209 Common - glycerol-3-phosphate dehydrogenase (NAD(P)+) RrIowa_0734 211 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 165932747 Common nusG transcription antitermination protein RrIowa_0218 216 COG0250 NusG, Transcription antiterminator Transcription 165932904 Common - hypothetical protein RrIowa_0392 6 None None None 165933790 Common - hypothetical protein RrIowa_1442 21 COG3671 COG3671, Predicted membrane protein Function unknown 165933527 Common ntrY nitrogen regulation protein RrIowa_1124 221 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 165933651 Common - hypothetical protein RrIowa_1284 2 None None None 165933260 Common - hypothetical cytosolic protein RrIowa_0800 180 COG1496 COG1496, Uncharacterized conserved protein Function unknown 165932623 Common - SSU ribosomal protein S6P RrIowa_0084 196 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 165933836 Common radC.1 DNA repair protein RrIowa_1499 48 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 165932634 Common - prolipoprotein diacylglyceryl transferase RrIowa_0095 206 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 165933706 Common - glutaredoxin RrIowa_1355 127 COG0278 COG0278, Glutaredoxin-related protein Posttranslational modification, protein turnover, chaperones 165933551 Common grpE GrpE RrIowa_1156 230 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 165933327 Common - hypothetical cytosolic protein RrIowa_0878 45 COG4804 COG4804, Uncharacterized conserved protein Function unknown 165933882 Pathogen - hypothetical protein RrIowa_1547 1 None None None 165933226 Pathogen - hypothetical protein RrIowa_0753 1 None None None 165933374 Pathogen - hypothetical protein RrIowa_0932 1 None None None 165933318 Common iscU IscU RrIowa_0867 146 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 165933358 Common - DNA adenine methylase RrIowa_0915 18 COG0338 Dam, Site-specific DNA methylase DNA replication, recombination, and repair 165933593 Common - hypothetical protein RrIowa_1205 2 COG4118 Phd, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 165933549 Pathogen - hypothetical protein RrIowa_1150 1 None None None 165932804 Common cutA periplasmic divalent cation tolerance protein RrIowa_0278 114 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 165933293 Pathogen - hypothetical protein RrIowa_0838 2 None None None 165933933 Common - uroporphyrinogen decarboxylase RrIowa_1604 180 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 165932586 Common - hypothetical protein RrIowa_0039 3 COG5336 COG5336, Uncharacterized protein conserved in bacteria Function unknown 165933807 Common - hypothetical protein RrIowa_1463 1 None None None 165933413 Common - hypothetical protein RrIowa_0976 10 None None None 165933011 Common - hypothetical protein RrIowa_0514 186 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 165932960 Common shaD sodium/proton antiporter protein RrIowa_0461 163 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 165933542 Common znuB high-affinity zinc uptake system membrane protein RrIowa_1139 168 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 165933269 Common bioY BioY RrIowa_0811 94 COG1268 BioY, Uncharacterized conserved protein General function prediction only 165933917 Common - hypothetical protein RrIowa_1584 1 None None None 165932658 Common - HesB protein family RrIowa_0121 164 COG0316 IscA, Uncharacterized conserved protein Function unknown 165933108 Pathogen - hypothetical protein RrIowa_0627 1 None None None 165933386 Pathogen - hypothetical protein RrIowa_0946 1 None None None 165932610 Common - hypothetical protein RrIowa_0065 1 None None None 165933395 Common - ribosomal large subunit pseudouridine synthase B RrIowa_0958 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 165933252 Pathogen - hypothetical protein RrIowa_0792 1 None None None 165932858 Common - S-adenosylmethionine:tRNA ribosyltransferase-isomerase RrIowa_0343 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 165933674 Common - hypothetical protein RrIowa_1317 1 None None None 165933775 Common virB4.2 VirB4 ATPase RrIowa_1427 44 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 165932688 Common - hypothetical lipoprotein RrIowa_0152 42 COG2121 COG2121, Uncharacterized protein conserved in bacteria Function unknown 165933735 Common - hypothetical protein RrIowa_1384 1 None None None 165933553 Common - DnaA-related protein RrIowa_1158 65 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 165932682 Common - protein translation elongation factor Ts (EF-Ts) RrIowa_0146 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 165932934 Common - isocitrate dehydrogenase (NADP) RrIowa_0425 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 165932693 Common - lipoprotein RrIowa_0157 94 COG2853 VacJ, Surface lipoprotein Cell envelope biogenesis, outer membrane 165933021 Common - hypothetical protein RrIowa_0524 14 COG5464 COG5464, Uncharacterized conserved protein Function unknown 165933909 Common yafQ DNA damage inducible protein RrIowa_1575 15 COG3041 COG3041, Uncharacterized protein conserved in bacteria Function unknown 165933343 Common - porphobilinogen deaminase RrIowa_0898 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 165933892 Common - NAD(P) transhydrogenase alpha subunit RrIowa_1558 117 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 165933519 Common - ribonuclease P protein component RrIowa_1112 1 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 165933447 Common - permeases (major facilitator family) RrIowa_1024 128 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 165932775 Pathogen - hypothetical protein RrIowa_0246 1 None None None 165933512 Common - GTP-binding protein, probable translation factor RrIowa_1103 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 165933685 Pathogen - hypothetical protein RrIowa_1328 1 None None None 165932861 Pathogen - hypothetical protein RrIowa_0346 1 None None None 165933691 Pathogen - hypothetical protein RrIowa_1335 1 None None None 165932758 Common - aspartyl-tRNA synthetase RrIowa_0229 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 165933491 Common - Trp repressor binding protein RrIowa_1079 11 None None None 165933202 Common - hypothetical protein RrIowa_0727 1 None None None 165933453 Pathogen - hypothetical protein RrIowa_1033 1 None None None 165933046 Common - alpha/beta hydrolase family protein RrIowa_0555 73 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 165933589 Common - protein translation elongation factor Tu (EF-TU) RrIowa_1199 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 165933628 Common - valyl-tRNA synthetase RrIowa_1254 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 165933715 Common - hypothetical protein RrIowa_1364 1 None None None 165932740 Common - succinate dehydrogenase membrane anchor subunit RrIowa_0210 26 COG2142 SdhD, Succinate dehydrogenase, hydrophobic anchor subunit Energy production and conversion 165932984 Common - zinc metalloprotease RrIowa_0485 137 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 165932662 Common - hypothetical protein RrIowa_0125 2 None None None 165933007 Common - proline/betaine transporter RrIowa_0510 124 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 165932593 Pathogen - chlamydia protein associating with death domains RrIowa_0046 1 None None None 165932791 Common - signal recognition particle, subunit FFH/SRP54 RrIowa_0263 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 165933774 Common - hypothetical protein RrIowa_1426 1 None None None 165932813 Common dnaJ chaperone protein RrIowa_0287 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 165932626 Pathogen - hypothetical protein RrIowa_0087 1 None None None 165933830 Common - outer membrane protein A RrIowa_1493 51 COG4625 COG4625, Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain Function unknown 165932853 Common - peptide deformylase RrIowa_0336 213 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 165932955 Common - protease II RrIowa_0456 104 COG1770 PtrB, Protease II Amino acid transport and metabolism 165933134 Common - deoxyuridine 5'-triphosphate nucleotidohydrolase RrIowa_0653 182 COG0756 Dut, dUTPase Nucleotide transport and metabolism 165933342 Pathogen - hypothetical protein RrIowa_0897 1 None None None 165932898 Pathogen - hypothetical protein RrIowa_0386 1 None None None 165932716 Common virB6.3 channel protein RrIowa_0181 8 COG3704 VirB6, Type IV secretory pathway, VirB6 components Intracellular trafficking and secretion 165933146 Common - hypothetical protein RrIowa_0665 1 None None None 165933817 Pathogen - hypothetical protein RrIowa_1479 1 None None None 165933169 Common - phenylalanyl-tRNA synthetase beta chain RrIowa_0694 234 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 165932798 Pathogen - hypothetical protein RrIowa_0272 1 None None None 165933408 Pathogen - hypothetical protein RrIowa_0971 1 None None None 165933839 Common - hypothetical protein RrIowa_1502 1 COG5389 COG5389, Uncharacterized protein conserved in bacteria Function unknown 165933401 Common - hypothetical protein RrIowa_0964 1 None None None 165933321 Common - Rrf2 family protein RrIowa_0870 153 COG1959 COG1959, Predicted transcriptional regulator Transcription 165933162 Pathogen - acriflavin resistance periplasmic protein RrIowa_0683 1 None None None 165933188 Common - succinyl-CoA synthetase beta chain RrIowa_0713 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 165933870 Common - hypothetical protein RrIowa_1534 1 None None None 165933566 Common - adenylate kinase RrIowa_1176 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 165932557 Common - (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase RrIowa_0008 186 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 165933632 Common - hypothetical protein RrIowa_1260 1 None None None 165933489 Common - succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B RrIowa_1077 94 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 165933710 Pathogen - hypothetical protein RrIowa_1359 1 None None None 165932603 Pathogen - hypothetical protein RrIowa_0058 1 None None None 165932719 Pathogen - hypothetical protein RrIowa_0189 1 None None None 165932831 Pathogen - hypothetical protein RrIowa_0308 1 None None None 165933060 Common - DNA-3-methyladenine glycosylase II RrIowa_0572 84 COG2094 Mpg, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 165933733 Common - NAD-specific glutamate dehydrogenase RrIowa_1382 77 COG2902 COG2902, NAD-specific glutamate dehydrogenase Amino acid transport and metabolism 165933619 Pathogen - hypothetical protein RrIowa_1240 1 None None None 165932886 Common - hypothetical protein RrIowa_0373 1 None None None 165933420 Pathogen - hypothetical protein RrIowa_0984 1 None None None 165933636 Common - NADH-ubiquinone oxidoreductase 39-40 kDa subunit-like protein RrIowa_1268 2 None None None 165933099 Pathogen - hypothetical protein RrIowa_0616 1 None None None 165932589 Common - methyltransferase RrIowa_0042 40 COG4797 COG4797, Predicted regulatory domain of a methyltransferase General function prediction only 165933000 Pathogen - hypothetical protein RrIowa_0503 1 None None None 165933349 Common - aminomethyltransferase family protein RrIowa_0906 73 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 165933087 Common - NADP-dependent malic enzyme RrIowa_0602 208 COG0281 SfcA, Malic enzyme Energy production and conversion 165932891 Common - hypothetical protein RrIowa_0378 2 None None None 165932946 Common - hypothetical cytosolic protein RrIowa_0439 43 None None None 165933115 Common ruvA Holliday junction DNA helicase RrIowa_0634 210 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 165933478 Common yajC protein translocase subunit RrIowa_1063 174 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 165932577 Common - hypothetical protein RrIowa_0029 3 COG4625 COG4625, Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain Function unknown 165933324 Pathogen - hypothetical protein RrIowa_0875 1 None None None 165932760 Pathogen - hypothetical protein RrIowa_0231 1 None None None 165932714 Common virB6.1 channel protein RrIowa_0179 7 COG3704 VirB6, Type IV secretory pathway, VirB6 components Intracellular trafficking and secretion 165933717 Common - hypothetical protein RrIowa_1366 17 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 165932777 Pathogen - hypothetical protein RrIowa_0248 1 None None None 165933282 Common - bacterial peptide chain release factor 1 (RF-1) RrIowa_0827 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 165933645 Common - hypothetical protein RrIowa_1278 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 165932866 Common relB.2 RelB RrIowa_0351 16 COG2161 StbD, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 165933821 Common maf septum formation protein RrIowa_1484 182 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 165932939 Common - ubiquinol-cytochrome c reductase iron-sulfur subunit RrIowa_0430 109 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 165933356 Common bioC biotin synthesis protein RrIowa_0913 60 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 165933396 Common - hypothetical protein RrIowa_0959 55 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 165932783 Pathogen - hypothetical protein RrIowa_0255 1 None None None 165933159 Common - acriflavin resistance plasma membrane protein RrIowa_0678 89 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 165933242 Common - ribonucleoside-diphosphate reductase beta chain RrIowa_0779 158 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 165933228 Common - hypothetical protein RrIowa_0757 2 None None None 165933899 Pathogen - hypothetical protein RrIowa_1565 1 None None None 165933765 Pathogen - hypothetical protein RrIowa_1417 1 None None None 165932727 Common - ribonuclease III RrIowa_0197 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 165933313 Common - decaprenyl diphosphate synthase RrIowa_0859 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 165933009 Common - type I protein secretion ATP-binding protein RrIowa_0512 249 COG4618 ArpD, ABC-type protease/lipase transport system, ATPase and permease components General function prediction only 165933059 Common - hypothetical protein RrIowa_0568 13 COG5304 COG5304, Uncharacterized protein conserved in bacteria Function unknown 165933573 Common - SSU ribosomal protein S8P RrIowa_1183 230 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 165932674 Common - transporter, MFS superfamily RrIowa_0137 133 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 165932735 Common hflK protease activity modulator RrIowa_0205 152 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 165933433 Common ntrX nitrogen assimilation regulatory protein RrIowa_1010 221 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 165933033 Pathogen - hypothetical protein RrIowa_0542 1 None None None 165933069 Common - hypothetical protein RrIowa_0581 16 COG4765 COG4765, Uncharacterized protein conserved in bacteria Function unknown 165933211 Common - 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase RrIowa_0736 81 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 165933375 Common mazG MazG RrIowa_0933 46 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 165933787 Common - NADH-quinone oxidoreductase chain I RrIowa_1439 195 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 165933465 Pathogen - hypothetical protein RrIowa_1046 1 None None None 165933507 Common - patatin-like protein RrIowa_1095 21 COG3621 COG3621, Patatin General function prediction only 165933786 Common - heme exporter protein A RrIowa_1438 247 COG4133 CcmA, ABC-type transport system involved in cytochrome c biogenesis, ATPase component Posttranslational modification, protein turnover, chaperones 165933234 Common - hypothetical protein RrIowa_0765 1 COG3121 FimC, P pilus assembly protein, chaperone PapD Cell motility and secretion / Intracellular trafficking and secretion 165933152 Pathogen - hypothetical protein RrIowa_0671 1 None None None 165933603 Common - dimethyladenosine transferase RrIowa_1216 247 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 165933077 Common - ABC transporter substrate-binding protein RrIowa_0592 45 COG2984 COG2984, ABC-type uncharacterized transport system, periplasmic component General function prediction only 165933844 Common - tRNA-specific adenosine deaminase RrIowa_1507 207 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 165932983 Common - peptidoglycan-specific endopeptidase, M23 family RrIowa_0484 26 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 165932970 Common - exopolyphosphatase RrIowa_0471 101 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 165932849 Pathogen - hypothetical protein RrIowa_0330 1 None None None 165932615 Common - acetoacetyl-CoA reductase RrIowa_0072 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 165933118 Common ruvB Holliday junction DNA helicase RrIowa_0637 240 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 165933929 Common - hypothetical protein RrIowa_1597 119 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 165933330 Common - hypothetical protein RrIowa_0883 1 None None None 165933867 Common - trigger factor, ppiase RrIowa_1531 215 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 165933823 Common - integrase/recombinase (XerC/CodV family) RrIowa_1486 224 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 165933497 Common - transcription-repair coupling factor RrIowa_1085 218 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 165933221 Pathogen - hypothetical protein RrIowa_0746 1 None None None 165932994 Common - ABC transporter ATP-binding protein RrIowa_0495 201 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 165932826 Pathogen - hypothetical protein RrIowa_0300 1 None None None 165932559 Pathogen - hypothetical protein RrIowa_0010 1 None None None 165933792 Common - ATP synthase epsilon chain RrIowa_1444 101 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 165933740 Pathogen - hypothetical protein RrIowa_1389 1 None None None 165933193 Common - cytochrome b561 RrIowa_0718 1 COG3038 CybB, Cytochrome B561 Energy production and conversion 165932645 Common - nucleoside diphosphate kinase RrIowa_0108 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 165933920 Common - lipoate-protein ligase B RrIowa_1587 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 165933320 Common - cysteine desulfhydrase RrIowa_0869 216 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 165932855 Pathogen - hypothetical protein RrIowa_0338 1 None None None 165933777 Common terC tellurium resistance protein RrIowa_1429 92 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 165932718 Common virB6.5 channel protein RrIowa_0183 10 COG3704 VirB6, Type IV secretory pathway, VirB6 components Intracellular trafficking and secretion 165932670 Common - hypothetical cytosolic protein RrIowa_0133 41 COG3820 COG3820, Uncharacterized protein conserved in bacteria Function unknown 165932742 Common - hypothetical protein RrIowa_0212 175 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 165933138 Common - ATP-dependent nuclease subunit B RrIowa_0657 50 COG2887 COG2887, RecB family exonuclease DNA replication, recombination, and repair 165933445 Pathogen - hypothetical protein RrIowa_1022 1 None None None 165933513 Common - peptidyl-tRNA hydrolase RrIowa_1106 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 165932731 Common - nucleotidyltransferase RrIowa_0201 6 None None None 165933627 Common - 4-hydroxybenzoate polyprenyltransferase RrIowa_1250 160 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 165933384 Common - hypothetical protein RrIowa_0944 1 None None None 165933148 Common ftsW cell division protein RrIowa_0667 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 165933751 Common - hypothetical protein RrIowa_1400 1 None None None 165933403 Pathogen - hypothetical protein RrIowa_0966 1 None None None 165933367 Common - hypothetical cytosolic protein RrIowa_0924 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 165933916 Common - hypothetical protein RrIowa_1583 1 None None None 165932724 Common secF protein translocase subunit RrIowa_0194 215 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 165933173 Pathogen - hypothetical protein RrIowa_0698 1 None None None 165933569 Common - LSU ribosomal protein L30P RrIowa_1179 90 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 165933811 Common - iojap protein family RrIowa_1467 194 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 165933500 Common dnaA chromosomal replication initiator protein RrIowa_1088 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 165933248 Common - hypothetical protein RrIowa_0788 1 COG1934 COG1934, Uncharacterized protein conserved in bacteria Function unknown 165933437 Common - cell elongation specific D,D-transpeptidase RrIowa_1014 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 165933345 Common resE.1 sensor protein RrIowa_0900 1 None None None 165933855 Common - excinuclease ABC subunit A RrIowa_1518 241 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 165932749 Common - LSU ribosomal protein L1P RrIowa_0220 242 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 165932713 Common virB4.1 VirB4 ATPase RrIowa_0178 66 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 165932762 Common - dihydrodipicolinate reductase RrIowa_0233 216 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 165932595 Pathogen - hypothetical protein RrIowa_0048 1 None None None 165933890 Common - cytidylyltransferase family protein RrIowa_1556 11 COG0170 SEC59, Dolichol kinase Lipid metabolism 165933880 Common - hypothetical protein RrIowa_1544 17 None None None 165932864 Common - cyanide-insensitive cytochrome bd-type quinol oxidase subunit I RrIowa_0349 164 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 165933299 Pathogen - hypothetical protein RrIowa_0845 1 None None None 165933800 Pathogen - hypothetical protein RrIowa_1452 1 None None None 165933057 Common - hypothetical protein RrIowa_0566 10 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 165933875 Common - hypothetical protein RrIowa_1539 1 None None None 165933365 Pathogen - hypothetical protein RrIowa_0922 1 None None None 165933451 Common - hypothetical protein RrIowa_1028 25 COG4912 COG4912, Predicted DNA alkylation repair enzyme DNA replication, recombination, and repair 165933741 Pathogen - hypothetical protein RrIowa_1390 1 None None None 165933329 Common - isopentenyl-diphosphate delta-isomerase RrIowa_0882 81 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 165933694 Pathogen - hypothetical protein RrIowa_1343 1 None None None 165933907 Common - phosphoesterase, PAP2 family RrIowa_1573 7 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 165932950 Pathogen - outer membrane protein A RrIowa_0446 1 None None None 165932646 Common - glucose inhibited division protein A RrIowa_0109 191 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 165932685 Pathogen - hypothetical protein RrIowa_0149 1 None None None 165933239 Common - ribonucleoside-diphosphate reductase alpha chain RrIowa_0776 220 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 165933124 Common - lipoprotein RrIowa_0643 61 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 165932656 Pathogen - hypothetical protein RrIowa_0119 1 None None None 165932653 Common - hypothetical protein RrIowa_0116 1 None None None 165933001 Common tolQ TolQ RrIowa_0504 151 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 165933832 Pathogen - hypothetical protein RrIowa_1495 1 None None None 165933587 Common - LSU ribosomal protein L3P RrIowa_1197 222 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 165932885 Pathogen - hypothetical protein RrIowa_0372 1 None None None 165933658 Common - anhydromuramoyl-peptide exo-beta-N-acetylglucosaminidase RrIowa_1297 171 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 165932702 Common - hypothetical protein RrIowa_0166 1 None None None 165932944 Common - hypothetical protein RrIowa_0437 1 None None None 165933654 Common - hypothetical protein RrIowa_1289 1 None None None 165933151 Pathogen - hypothetical protein RrIowa_0670 1 None None None 165932971 Pathogen - hypothetical protein RrIowa_0472 1 None None None 165933230 Common - Methenyltetrahydrofolate cyclohydrolase RrIowa_0761 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 165933485 Common - hypothetical protein RrIowa_1070 4 None None None 165933560 Pathogen - hypothetical protein RrIowa_1169 1 None None None 165933196 Pathogen - hypothetical protein RrIowa_0721 2 None None None 165932986 Common tolB TolB RrIowa_0487 153 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 165933805 Pathogen - hypothetical protein RrIowa_1457 1 None None None 165933458 Pathogen - hypothetical protein RrIowa_1038 1 None None None 165933572 Common - LSU ribosomal protein L6P RrIowa_1182 243 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 165932906 Common - CDP-diacylglycerol--serine O-phosphatidyltransferase RrIowa_0394 153 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 165933682 Common - DNA polymerase III, epsilon chain RrIowa_1325 191 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 165933900 Common - retroviral aspartyl protease family protein RrIowa_1566 45 COG3577 COG3577, Predicted aspartyl protease General function prediction only 165933068 Common - O-antigen polymerase RrIowa_0580 2 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 165932667 Common secB protein translocase subunit RrIowa_0130 107 COG1952 SecB, Preprotein translocase subunit SecB Intracellular trafficking and secretion 165933393 Common - hypothetical protein RrIowa_0953 2 None None None 165933186 Common - outer membrane protein RrIowa_0711 84 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 165933559 Common - guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase RrIowa_1168 1 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 165933028 Common - glutamyl-tRNA synthetase RrIowa_0535 248 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 165933125 Common - intracellular septation protein RrIowa_0644 92 COG2917 COG2917, Intracellular septation protein A Cell division and chromosome partitioning 165933734 Common - tRNA (5-carboxymethylaminomethyl-2-thiouridylate) synthase RrIowa_1383 219 COG0486 ThdF, Predicted GTPase General function prediction only 165933229 Common - ribosome-associated factor Y RrIowa_0758 101 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 165933888 Common rpoD RNA polymerase sigma factor RrIowa_1554 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 165933930 Common - coproporphyrinogen III oxidase RrIowa_1598 113 COG0408 HemF, Coproporphyrinogen III oxidase Coenzyme metabolism 165933592 Common - fumarate hydratase RrIowa_1204 225 COG0114 FumC, Fumarase Energy production and conversion 165932927 Common - pyruvate dehydrogenase E1 component alpha subunit RrIowa_0418 158 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 165933013 Common - hypothetical protein RrIowa_0516 1 None None None 165932806 Common - dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarate dehydrogenase complex RrIowa_0280 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 165933232 Pathogen - hypothetical protein RrIowa_0763 1 None None None 165933846 Common - 17 kDa common-antigen RrIowa_1509 27 COG4520 LipA, Surface antigen Cell envelope biogenesis, outer membrane 165932573 Common - hypothetical protein RrIowa_0025 2 None None None 165933300 Pathogen - hypothetical protein RrIowa_0846 1 COG3077 RelB, DNA-damage-inducible protein J DNA replication, recombination, and repair 165932937 Common - heme exporter protein B RrIowa_0428 2 COG2386 CcmB, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 165933679 Common - hypothetical protein RrIowa_1322 40 COG3814 COG3814, Uncharacterized protein conserved in bacteria Function unknown 165933066 Common - NADH-quinone oxidoreductase chain B RrIowa_0578 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 165932644 Common uhpC regulatory protein RrIowa_0107 156 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 165932598 Common - hypothetical protein RrIowa_0053 1 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 165932725 Common - NADH-quinone oxidoreductase chain F RrIowa_0195 165 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 165933075 Pathogen - hypothetical protein RrIowa_0590 1 None None None 165932847 Pathogen - hypothetical protein RrIowa_0328 1 None None None 165933498 Common - hypothetical protein RrIowa_1086 26 COG2938 COG2938, Uncharacterized conserved protein Function unknown 165932613 Pathogen - hypothetical protein RrIowa_0068 1 None None None 165933711 Pathogen - hypothetical protein RrIowa_1360 1 None None None 165933785 Common - NADH-quinone oxidoreductase chain M RrIowa_1437 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 165933112 Common - prolyl-tRNA synthetase RrIowa_0631 248 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 165933332 Common - SSU ribosomal protein S1P RrIowa_0886 215 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 165932796 Pathogen - hypothetical protein RrIowa_0270 1 None None None 165933135 Common - soluble lytic murein transglycosylase RrIowa_0654 148 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 165932956 Common - NADH-quinone oxidoreductase chain L family protein RrIowa_0457 54 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 165933815 Pathogen - outer membrane protein A RrIowa_1474 1 None None None 165932842 Common - ribonuclease HII RrIowa_0321 210 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 165933533 Common - isoleucyl-tRNA synthetase RrIowa_1130 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 165933798 Common - ferroxidase RrIowa_1450 101 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 165933164 Common - glycosyltransferase RrIowa_0687 224 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 165932712 Common virB3 channel protein RrIowa_0177 17 COG3702 VirB3, Type IV secretory pathway, VirB3 components Intracellular trafficking and secretion 165932587 Common dsbA thiol:disulfide interchange protein RrIowa_0040 69 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 165933335 Common - hypothetical protein RrIowa_0890 2 None None None 165933825 Common - phospholipase D RrIowa_1488 30 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 165933050 Common - SSU ribosomal protein S4P RrIowa_0559 222 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 165932999 Pathogen - hypothetical protein RrIowa_0502 1 None None None 165932620 Common - O-sialoglycoprotein endopeptidase RrIowa_0081 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 165932992 Common - histidyl-tRNA synthetase RrIowa_0493 248 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 165932871 Pathogen - hypothetical protein RrIowa_0356 1 None None None 165932876 Common - hypothetical protein RrIowa_0361 1 COG4987 CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 165932973 Pathogen - hypothetical protein RrIowa_0474 1 None None None 165932680 Common - cysteinyl-tRNA synthetase RrIowa_0144 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 165933483 Common mviN virulence factor RrIowa_1068 192 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 165933191 Common - hypothetical protein RrIowa_0716 2 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 165933261 Common - glutamine synthetase RrIowa_0801 214 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 165933310 Common - lipopolysaccharide 1,2-glucosyltransferase RrIowa_0856 1 COG1442 RfaJ, Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases Cell envelope biogenesis, outer membrane 165933511 Common - hypothetical protein RrIowa_1102 1 None None None 165933205 Pathogen - hypothetical protein RrIowa_0730 1 None None None 165933915 Common - type I restriction-modification system methylation subunit RrIowa_1582 75 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 165933431 Common - 2-polyprenyl-6-methoxyphenol hydroxylase RrIowa_1008 117 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 165932633 Common - hypothetical cytosolic protein RrIowa_0094 91 COG1565 COG1565, Uncharacterized conserved protein Function unknown 165933353 Common - 5-formyltetrahydrofolate cyclo-ligase RrIowa_0910 73 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 165932961 Common shaC sodium/proton antiporter protein RrIowa_0462 81 COG1006 MnhC, Multisubunit Na+/H+ antiporter, MnhC subunit Inorganic ion transport and metabolism 165933862 Common - hypothetical cytosolic protein RrIowa_1526 14 COG1872 COG1872, Uncharacterized conserved protein Function unknown 165932755 Common - cytosol aminopeptidase RrIowa_0226 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 165933763 Common - S-adenosylmethionine synthetase RrIowa_1415 209 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 165933039 Common - UDP-2-acetamido-2,6-dideoxy-beta-L-talose 2-epimerase RrIowa_0548 155 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 165933615 Common - hypothetical protein RrIowa_1234 1 None None None 165933617 Common - formamidopyrimidine-DNA glycosylase RrIowa_1236 182 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 165932918 Common - hypothetical protein RrIowa_0406 2 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 165932882 Common - hypothetical protein RrIowa_0369 1 None None None 165933405 Common - N utilization substance protein A RrIowa_0968 216 COG0195 NusA, Transcription elongation factor Transcription 165932605 Common - cytochrome c oxidase Cu(A) center assembly protein RrIowa_0060 82 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 165932780 Common - N utilization substance protein B RrIowa_0252 56 COG0781 NusB, Transcription termination factor Transcription 165932893 Common - LSU ribosomal protein L13P RrIowa_0380 215 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 165933253 Common - polynucleotide adenylyltransferase RrIowa_0793 237 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 165932828 Pathogen - hypothetical protein RrIowa_0302 1 None None None 165933266 Common - pyruvate,phosphate dikinase RrIowa_0808 236 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 165932738 Common - rhodanese-related sulfurtransferase RrIowa_0208 111 COG1054 COG1054, Predicted sulfurtransferase General function prediction only 165933719 Common - phosphatidylglycerophosphatase A RrIowa_1368 93 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 165932816 Pathogen - hypothetical protein RrIowa_0290 1 None None None 165932675 Pathogen - hypothetical protein RrIowa_0138 1 None None None 165933222 Pathogen - hypothetical protein RrIowa_0747 1 None None None 165933216 Common - succinate-semialdehyde dehydrogenase (NADP+) RrIowa_0741 221 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 165933490 Common - Trp repressor binding protein RrIowa_1078 37 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 165933475 Common - proline/betaine transporter RrIowa_1057 1 None None None 165932773 Common - multidrug resistance protein B RrIowa_0244 186 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 165933105 Common - ADP,ATP carrier protein RrIowa_0622 6 COG3202 COG3202, ATP/ADP translocase Energy production and conversion 165933410 Common - Rrf2 family protein RrIowa_0973 125 COG1959 COG1959, Predicted transcriptional regulator Transcription 165933273 Common - biotin operon repressor RrIowa_0818 189 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 165933371 Pathogen - hypothetical protein RrIowa_0929 1 None None None 165933093 Common - proline/betaine transporter RrIowa_0608 114 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 165933322 Common - hypothetical protein RrIowa_0871 1 None None None 165933425 Common - 3-hydroxyacyl-CoA dehydrogenase RrIowa_1002 145 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 165932837 Common - immunogenic protein RrIowa_0316 73 COG2358 Imp, TRAP-type uncharacterized transport system, periplasmic component General function prediction only 165932555 Common - PEMK-like protein RrIowa_0006 14 COG2337 MazF, Growth inhibitor Signal transduction mechanisms 165933543 Common - 3-demethylubiquinone 3-methyltransferase RrIowa_1140 146 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 165932911 Common bolA.1 BolA RrIowa_0399 56 COG0271 BolA, Stress-induced morphogen (activity unknown) Signal transduction mechanisms 165933728 Pathogen - hypothetical protein RrIowa_1377 1 None None None 165933630 Common - LicD protein family RrIowa_1256 19 COG3475 COG3475, LPS biosynthesis protein Cell envelope biogenesis, outer membrane 165933257 Common - antigenic heat-stable 120 kDa protein RrIowa_0797 4 None None None 165933759 Common - lipoprotein (SmpA/OmlA family) RrIowa_1409 18 COG2913 SmpA, Small protein A (tmRNA-binding) Translation, ribosomal structure and biogenesis 165933317 Common - HesB protein family RrIowa_0866 166 COG0316 IscA, Uncharacterized conserved protein Function unknown 165932575 Common - hypothetical protein RrIowa_0027 1 None None None 165933813 Pathogen - hypothetical protein RrIowa_1471 1 None None None 165933369 Common - hypothetical cytosolic protein RrIowa_0927 5 None None None 165933526 Pathogen - hypothetical protein RrIowa_1120 1 None None None 165932567 Common - tRNA-dihydrouridine synthase RrIowa_0019 208 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 165933082 Pathogen - hypothetical protein RrIowa_0597 1 None None None 165933463 Pathogen - hypothetical protein RrIowa_1044 1 None None None 165932625 Common - LSU ribosomal protein L9P RrIowa_0086 216 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 165933531 Pathogen - hypothetical protein RrIowa_1128 1 None None None 165932832 Pathogen - hypothetical protein RrIowa_0309 1 None None None 165932895 Common - D-alanyl-D-alanine dipeptidase RrIowa_0383 6 None None None 165932748 Common - LSU ribosomal protein L11P RrIowa_0219 241 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 165932771 Common - uridylate kinase RrIowa_0242 242 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 165933688 Pathogen - hypothetical protein RrIowa_1331 1 None None None 165932978 Common - hypothetical protein RrIowa_0479 1 None None None 165933577 Common - LSU ribosomal protein L14P RrIowa_1187 247 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 165932660 Common - arginyl-tRNA synthetase RrIowa_0123 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 165933262 Common - peptide deformylase RrIowa_0802 100 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 165932818 Common - hypothetical protein RrIowa_0292 2 None None None 165933762 Common - S-adenosylmethionine synthetase RrIowa_1414 212 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 165932671 Common - NAD(P) transhydrogenase subunit beta RrIowa_0134 123 COG1282 PntB, NAD/NADP transhydrogenase beta subunit Energy production and conversion 165933439 Pathogen - hypothetical protein RrIowa_1016 1 None None None 165933681 Common - hypothetical protein RrIowa_1324 136 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 165932698 Common - alanine racemase RrIowa_0162 200 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 165933363 Common - hypothetical protein RrIowa_0920 1 None None None 165933180 Common - undecaprenyl pyrophosphate synthetase RrIowa_0705 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 165933666 Common - protein involved in external DNA uptake RrIowa_1305 84 COG2961 ComJ, Protein involved in catabolism of external DNA General function prediction only 165933207 Common - ATP-NAD kinase RrIowa_0732 210 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 165932597 Pathogen - hypothetical protein RrIowa_0052 1 None None None 165932734 Common apbC iron-sulfur cluster assembly/repair protein RrIowa_0204 235 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 165933055 Common - outer membrane assembly protein RrIowa_0564 72 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 165933003 Common tolA TolA RrIowa_0506 9 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 165932873 Pathogen - hypothetical protein RrIowa_0358 1 None None None 165933030 Pathogen - hypothetical protein RrIowa_0539 1 None None None 165933200 Common - hypothetical membrane spanning protein RrIowa_0725 23 COG1714 COG1714, Predicted membrane protein/domain Function unknown 165933700 Common - hemolysin RrIowa_1349 219 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 165933479 Common secD protein translocase subunit RrIowa_1064 220 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 165933113 Common - Fic family protein RrIowa_0632 115 COG3177 COG3177, Uncharacterized conserved protein Function unknown 165932917 Common ftsA cell division protein RrIowa_0405 176 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 165933443 Common mraW S-adenosyl-methyltransferase RrIowa_1020 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 165933129 Common - FKBP-type peptidyl-prolyl cis-trans isomerase RrIowa_0648 2 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 165932974 Pathogen - hypothetical protein RrIowa_0475 1 None None None 165933122 Common - D-alanyl-D-alanine serine-type carboxypeptidase RrIowa_0641 154 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 165933769 Common - hypothetical protein RrIowa_1421 1 None None None 165933623 Common - DNase, TatD family RrIowa_1246 237 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 165933625 Common - thymidylate kinase RrIowa_1248 225 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 165933927 Common - hypothetical protein RrIowa_1595 1 None None None 165932744 Common - SSU ribosomal protein S7P RrIowa_0214 245 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 165933391 Pathogen - hypothetical protein RrIowa_0951 1 None None None 165933175 Common - leucyl-tRNA synthetase RrIowa_0700 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 165933120 Pathogen - hypothetical protein RrIowa_0639 1 None None None 165933803 Common - multimodular transpeptidase-transglycosylase PBP 1A RrIowa_1455 200 COG5009 MrcA, Membrane carboxypeptidase/penicillin-binding protein Cell envelope biogenesis, outer membrane 165933311 Common - ADP,ATP carrier protein RrIowa_0857 7 COG3202 COG3202, ATP/ADP translocase Energy production and conversion 165933753 Common mreB rod shape-determining protein RrIowa_1402 234 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 165933582 Common - LSU ribosomal protein L22P RrIowa_1192 219 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 165933015 Common hslU ATP-dependent endopeptidase hsl ATP-binding subunit RrIowa_0518 211 COG1220 HslU, ATP-dependent protease HslVU (ClpYQ), ATPase subunit Posttranslational modification, protein turnover, chaperones 165933857 Common - hypothetical protein RrIowa_1520 10 None None None 165932665 Common - hypothetical protein RrIowa_0128 6 None None None 165933557 Pathogen - hypothetical protein RrIowa_1164 1 None None None 165933523 Common - hypothetical protein RrIowa_1116 1 None None None 165933707 Common - endonuclease III RrIowa_1356 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 165933535 Pathogen - hypothetical protein RrIowa_1132 1 None None None 165933886 Common - alanyl-tRNA synthetase RrIowa_1552 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 165933488 Common - succinyl-CoA:3-ketoacid-coenzyme A transferase subunit A RrIowa_1076 94 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 165933574 Common - SSU ribosomal protein S14P RrIowa_1184 199 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 165933381 Common - hypothetical ATP-binding protein RrIowa_0941 1 None None None 165933140 Common - glutamine amidotransferase, class I RrIowa_0659 142 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 165933154 Pathogen - hypothetical protein RrIowa_0673 1 None None None 165933732 Common - transcriptional regulator RrIowa_1381 27 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 165932925 Common - hypothetical protein RrIowa_0413 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 165932800 Pathogen - hypothetical protein RrIowa_0274 1 None None None 165932845 Common - multidrug resistance ABC transporter ATP-binding and permease protein RrIowa_0326 245 COG5265 ATM1, ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components Posttranslational modification, protein turnover, chaperones 165933604 Common - hypothetical protein RrIowa_1217 14 None None None 165933597 Common - ecotin precursor RrIowa_1209 20 COG4574 Eco, Serine protease inhibitor ecotin General function prediction only 165933895 Common - DNA polymerase III subunit gamma/tau RrIowa_1561 247 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 165933294 Pathogen - hypothetical protein RrIowa_0839 1 None None None 165932636 Common - mechanosensitive ion channel RrIowa_0097 62 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 165933545 Common - hypothetical protein RrIowa_1142 1 COG5342 COG5342, Invasion protein B, involved in pathogenesis General function prediction only 165933652 Common corB magnesium and cobalt efflux protein RrIowa_1285 219 COG4536 CorB, Putative Mg2+ and Co2+ transporter CorB Inorganic ion transport and metabolism 165932965 Common virB8.2 channel protein RrIowa_0466 28 COG3736 VirB8, Type IV secretory pathway, component VirB8 Intracellular trafficking and secretion 165933726 Pathogen - hypothetical protein RrIowa_1375 1 None None None 165932943 Common - small heat shock protein RrIowa_0436 51 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 165933198 Common - hypothetical protein RrIowa_0723 59 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 165933827 Common - poly(3-hydroxyalkanoate) polymerase RrIowa_1490 12 COG3243 PhaC, Poly(3-hydroxyalkanoate) synthetase Lipid metabolism 165933656 Common - outer membrane protein B RrIowa_1295 106 COG4625 COG4625, Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain Function unknown 165933246 Common - phosphomannomutase RrIowa_0786 240 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 165933170 Common - DNA polymerase III, beta chain RrIowa_0695 216 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 165933744 Common - acyl carrier protein RrIowa_1393 209 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 165933005 Pathogen - hypothetical protein RrIowa_0508 1 None None None 165933037 Common - UDP-2-acetamido-2,6-dideoxy-beta-L-mannose 4-dehydrogenase RrIowa_0546 123 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 165933599 Common ampG.3 AmpG RrIowa_1211 104 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 165932990 Common - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase RrIowa_0491 219 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 165933606 Common - exodeoxyribonuclease VII large subunit RrIowa_1219 204 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 165932649 Common parB chromosome partitioning protein RrIowa_0112 187 COG1475 Spo0J, Predicted transcriptional regulators Transcription 165933224 Common - serine racemase RrIowa_0749 211 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 165933613 Pathogen - hypothetical protein RrIowa_1232 1 None None None 165933351 Common - ribonuclease D RrIowa_0908 116 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 165932600 Pathogen - hypothetical protein RrIowa_0055 1 None None None 165933661 Common - hypothetical protein RrIowa_1300 4 None None None 165933873 Common - ribosomal large subunit pseudouridine synthase D RrIowa_1537 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 165932753 Common - DNA-directed RNA polymerase beta' chain RrIowa_0224 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 165933501 Common - hypothetical protein RrIowa_1089 1 COG5488 COG5488, Integral membrane protein Function unknown 165933043 Common - glycosyltransferase RrIowa_0552 209 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 165933302 Pathogen - hypothetical protein RrIowa_0848 1 None None None 165932627 Common tilS tRNA(Ile)-lysidine synthetase RrIowa_0088 208 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 165932878 Common - multidrug resistance ABC transporter ATP-binding and permease protein RrIowa_0363 128 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 165933643 Common - hypothetical protein RrIowa_1275 15 COG4226 HicB, Uncharacterized protein encoded in hypervariable junctions of pilus gene clusters Function unknown 165933897 Pathogen - hypothetical protein RrIowa_1563 1 None None None 165932931 Pathogen - hypothetical protein RrIowa_0422 1 None None None 165933924 Common mutL DNA mismatch repair protein RrIowa_1592 192 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 165933469 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase RrIowa_1050 208 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 165933073 Common - enoyl-[acyl-carrier protein] reductase (NADH) RrIowa_0588 225 COG0623 FabI, Enoyl- acyl-carrier-protein 165933782 Common - NADH-quinone oxidoreductase chain J RrIowa_1434 154 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 165933334 Common - transcriptional regulator RrIowa_0888 31 None None None 165932708 Common - LSU ribosomal protein L28P RrIowa_0172 109 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 165933585 Common - LSU ribosomal protein L23P RrIowa_1195 4 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 165933932 Common - ferrochelatase RrIowa_1603 176 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 165933281 Common - dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex RrIowa_0826 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 165933783 Common - NADH-quinone oxidoreductase chain K RrIowa_1435 163 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 165933796 Common - ATP synthase delta chain RrIowa_1448 160 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 165932611 Common - hypothetical protein RrIowa_0066 2 None None None 165933696 Common - poly-beta-hydroxybutyrate polymerase RrIowa_1345 18 COG3243 PhaC, Poly(3-hydroxyalkanoate) synthetase Lipid metabolism 165933110 Common - hypothetical protein RrIowa_0629 8 None None None 165933337 Pathogen - hypothetical protein RrIowa_0892 1 None None None 165932553 Common - O-antigen export system permease protein RrIowa_0004 108 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 165933156 Common - acriflavin resistance plasma membrane protein RrIowa_0675 170 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 165932585 Common - ATP synthase A chain RrIowa_0038 207 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 165932967 Common virB10 channel protein RrIowa_0468 58 COG2948 VirB10, Type IV secretory pathway, VirB10 components Intracellular trafficking and secretion 165933848 Common znuC high-affinity zinc uptake system ATP-binding protein RrIowa_1511 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 165932562 Common - hypothetical protein RrIowa_0013 1 None None None 165932565 Pathogen - hypothetical protein RrIowa_0016 1 None None None 165932709 Common - LSU ribosomal protein L31P RrIowa_0173 5 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 165933255 Common - tRNA pseudouridine synthase B RrIowa_0795 243 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 165933307 Pathogen - transporter, LysE family RrIowa_0853 1 None None None 165932830 Pathogen - hypothetical protein RrIowa_0307 1 None None None 165933071 Common - hypothetical protein RrIowa_0586 1 None None None 165933713 Common - entericidin B-like protein RrIowa_1362 1 COG5510 COG5510, Predicted small secreted protein Function unknown 165933646 Common - hypothetical protein RrIowa_1279 1 None None None 165933095 Common - hypothetical protein RrIowa_0610 1 None None None 165932722 Common - LSU ribosomal protein L19P RrIowa_0192 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 165932696 Common - ribose-phosphate pyrophosphokinase RrIowa_0160 110 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 165932807 Pathogen - hypothetical protein RrIowa_0281 1 None None None 165933219 Common - DNA helicase II RrIowa_0744 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 165932821 Common - cytochrome c oxidase polypeptide III RrIowa_0295 159 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 165933737 Pathogen - hypothetical protein RrIowa_1386 1 None None None 165932789 Common - DNA-binding protein HU RrIowa_0261 199 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 165933686 Common - hypothetical protein RrIowa_1329 1 None None None 165933080 Pathogen - hypothetical protein RrIowa_0595 1 None None None 165932835 Common - hypothetical protein RrIowa_0314 1 None None None 165933303 Common - tetratricopeptide repeat family protein RrIowa_0849 4 COG3071 HemY, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 165933423 Pathogen - hypothetical protein RrIowa_0989 1 None None None 165933104 Pathogen - hypothetical protein RrIowa_0621 1 None None None 165933181 Common envZ osmolarity sensor protein RrIowa_0706 216 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 165932880 Common - hypothetical protein RrIowa_0367 2 None None None 165933417 Common - hypothetical protein RrIowa_0981 1 None None None 165933286 Common sppA.2 signal peptide peptidase RrIowa_0831 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 165933670 Common - guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase RrIowa_1309 11 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 165932571 Common - periplasmic solute binding protein family RrIowa_0023 37 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 165933473 Pathogen - hypothetical protein RrIowa_1055 1 None None None 165933214 Pathogen - hypothetical protein RrIowa_0739 1 None None None 165933264 Pathogen - hypothetical protein RrIowa_0804 1 None None None 165933462 Pathogen - hypothetical protein RrIowa_1043 1 None None None 165933442 Common - hypothetical protein RrIowa_1019 1 COG5462 COG5462, Predicted secreted (periplasmic) protein Function unknown 165933271 Common - superoxide dismutase RrIowa_0813 207 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 165932968 Common virB11 virB11 ATPase RrIowa_0469 152 COG0630 VirB11, Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis Cell motility and secretion / Intracellular trafficking and secretion 165933649 Common lolD lipoprotein releasing system ATP-binding protein RrIowa_1282 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 165932764 Common - glutamine-binding protein RrIowa_0235 144 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 165932710 Common yihA GTP-binding protein RrIowa_0175 180 COG0218 COG0218, Predicted GTPase General function prediction only 165932677 Common secG protein translocase subunit RrIowa_0141 1 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 165932840 Common hscA chaperone protein RrIowa_0319 234 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones