Shewanella pealeana ATCC 700345, complete genome NC_009901 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 157962097 Common - Radical SAM domain protein Spea_2276 41 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 157962427 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Spea_2606 164 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 157963814 Common - hypothetical protein Spea_4003 37 COG3346 COG3346, Uncharacterized conserved protein Function unknown 157962474 Common - TonB-dependent receptor Spea_2653 57 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 157964010 Common - hypothetical protein Spea_4199 8 None None None 157964022 Nonpathogen - hypothetical protein Spea_4211 3 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 157963787 Common - transposase IS116/IS110/IS902 family protein Spea_3976 98 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 157963663 Nonpathogen - hypothetical protein Spea_3852 7 None None None 157961082 Common - transposase Spea_1254 8 None None None 157961807 Common - hypothetical protein Spea_1984 1 None None None 157963221 Common - peptidase S9 prolyl oligopeptidase active site domain protein Spea_3407 104 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 157961827 Common - Fmu (Sun) domain protein Spea_2006 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 157963726 Common - GTP-binding protein TypA Spea_3915 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 157963742 Common - cation diffusion facilitator family transporter Spea_3931 211 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 157962722 Common - transcriptional regulator, LysR family Spea_2903 140 COG0583 LysR, Transcriptional regulator Transcription 157963511 Nonpathogen - hypothetical protein Spea_3699 1 None None None 157962893 Common - carbamoyl-phosphate synthase, small subunit Spea_3075 234 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 157961777 Common - excinuclease ABC, C subunit Spea_1954 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 157961200 Nonpathogen - flagellar biosynthetic protein FliQ Spea_1372 1 COG1987 FliQ, Flagellar biosynthesis pathway, component FliQ Cell motility and secretion / Intracellular trafficking and secretion 157961390 Common - purine or other phosphorylase family 1 Spea_1564 114 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 157960394 Common - protein of unknown function DUF6 transmembrane Spea_0565 88 COG2962 RarD, Predicted permeases General function prediction only 157960454 Common - hypothetical protein Spea_0625 50 COG5621 COG5621, Predicted secreted hydrolase General function prediction only 157962277 Common - ATP phosphoribosyltransferase Spea_2456 211 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 157962734 Common - hypothetical protein Spea_2916 3 None None None 157962426 Common - hypothetical protein Spea_2605 30 None None None 157961728 Common - peptidylprolyl isomerase FKBP-type Spea_1905 128 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 157960230 Common - TonB-dependent receptor Spea_0401 32 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 157960695 Common - Nucleotidyl transferase Spea_0867 223 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 157962733 Common - hypothetical protein Spea_2915 7 None None None 157964029 Common - peptidase M23B Spea_4218 188 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 157961183 Common - hypothetical protein Spea_1355 1 None None None 157960247 Common - regulatory protein GntR HTH Spea_0418 143 COG2186 FadR, Transcriptional regulators Transcription 157963525 Common - 1-acyl-sn-glycerol-3-phosphate acyltransferase Spea_3713 142 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 157963052 Common - Curlin associated repeat protein Spea_3235 106 None None None 157963450 Common - hypothetical protein Spea_3638 4 COG1433 COG1433, Uncharacterized conserved protein Function unknown 157964018 Common - ABC transporter related Spea_4207 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 157962445 Common - DEAD/DEAH box helicase domain protein Spea_2624 234 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 157963549 Common - arsenical-resistance protein Spea_3737 138 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 157963400 Common - ribosomal protein S6 Spea_3586 143 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 157961607 Common - citrate synthase I Spea_1783 194 COG0372 GltA, Citrate synthase Energy production and conversion 157960072 Common - hypothetical protein Spea_0243 2 None None None 157962769 Common - PfkB domain protein Spea_2951 143 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 157963971 Common - iron-containing alcohol dehydrogenase Spea_4160 175 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 157963978 Common - transcriptional regulator, LysR family Spea_4167 188 COG0583 LysR, Transcriptional regulator Transcription 157963758 Common - peptidase M16 domain protein Spea_3947 168 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 157963218 Common - NAD(P)H dehydrogenase (quinone) Spea_3404 70 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 157960100 Common - small multidrug resistance protein Spea_0271 138 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 157961983 Common - short-chain dehydrogenase/reductase SDR Spea_2162 234 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157961346 Common - ROK family protein Spea_1520 106 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 157961295 Common - S-adenosylmethionine--tRNA-ribosyltransferase-isomerase Spea_1469 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 157961751 Common - nucleoside recognition domain protein Spea_1928 39 COG2715 SpmA, Uncharacterized membrane protein, required for spore maturation in B.subtilis. General function prediction only 157959999 Common - pantothenate kinase Spea_0169 79 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 157961460 Common - alpha/beta hydrolase fold Spea_1634 37 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 157963457 Common - putative transcriptional regulator, CopG family Spea_3645 64 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 157963797 Common - hypothetical protein Spea_3986 1 None None None 157960109 Common - protein of unknown function DUF1232 Spea_0280 44 COG3339 COG3339, Uncharacterized conserved protein Function unknown 157961060 Nonpathogen - hypothetical protein Spea_1232 1 None None None 157962439 Common - anaerobic ribonucleoside-triphosphate reductase activating protein Spea_2618 63 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 157960007 Common - DNA-directed RNA polymerase, beta subunit Spea_0177 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 157962794 Common - 5'-3' exonuclease Spea_2976 216 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 157963984 Common - AAA ATPase Spea_4173 32 COG3950 COG3950, Predicted ATP-binding protein involved in virulence General function prediction only 157962779 Common - periplasmic/7TM domain sensor diguanylate cyclase Spea_2961 31 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157960641 Common - FAD dependent oxidoreductase Spea_0813 149 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 157961224 Common - lipopolysaccharide biosynthesis protein Spea_1397 24 COG3765 WzzB, Chain length determinant protein Cell envelope biogenesis, outer membrane 157960363 Common - 3-dehydroquinate dehydratase, type II Spea_0534 169 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 157960169 Common - flavocytochrome c Spea_0340 210 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 157962392 Common - ribonuclease T Spea_2571 71 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 157962490 Common - phage shock protein A, PspA Spea_2669 80 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 157962228 Common - Lytic transglycosylase catalytic Spea_2407 124 COG4623 COG4623, Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein Cell envelope biogenesis, outer membrane 157960554 Common - ABC transporter related Spea_0726 249 COG3845 COG3845, ABC-type uncharacterized transport systems, ATPase components General function prediction only 157960033 Common - ribosomal protein L15 Spea_0203 178 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 157961169 Common - flagellar basal-body rod protein FlgC Spea_1341 126 COG1558 FlgC, Flagellar basal body rod protein Cell motility and secretion 157959844 Common - GCN5-related N-acetyltransferase Spea_0014 21 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 157962342 Common - hypothetical protein Spea_2521 4 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 157964000 Common - transcriptional regulator, GntR family Spea_4189 94 COG1725 COG1725, Predicted transcriptional regulators Transcription 157959944 Common - CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase Spea_0114 7 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 157962605 Common - Homoserine O-succinyltransferase Spea_2784 64 COG1897 MetA, Homoserine trans-succinylase Amino acid transport and metabolism 157960831 Common - GCN5-related N-acetyltransferase Spea_1003 55 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 157963896 Nonpathogen - hypothetical protein Spea_4085 2 None None None 157961263 Common - dTDP-4-dehydrorhamnose reductase Spea_1437 170 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 157962760 Common - hypothetical protein Spea_2942 70 COG0390 COG0390, ABC-type uncharacterized transport system, permease component General function prediction only 157963490 Common - cold-shock DNA-binding domain protein Spea_3678 23 COG1278 CspC, Cold shock proteins Transcription 157962466 Common - protein of unknown function DUF885 Spea_2645 44 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 157960083 Common - hypothetical protein Spea_0254 15 None None None 157963847 Common - L-carnitine dehydratase/bile acid-inducible protein F Spea_4036 113 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 157963942 Common - formate dehydrogenase, gamma subunit Spea_4131 66 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 157963436 Common - OmpA/MotB domain protein Spea_3624 171 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 157961195 Common - flagellar basal body-associated protein FliL Spea_1367 21 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 157960544 Common - hypothetical protein Spea_0716 56 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 157963873 Common - conserved hypothetical 3-methyladenine DNA glycosylase Spea_4062 41 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 157963967 Common - phospholipid/glycerol acyltransferase Spea_4156 41 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 157959968 Common - transcriptional regulator, XRE family Spea_0138 72 COG1476 COG1476, Predicted transcriptional regulators Transcription 157962233 Common - Ferric reductase domain protein transmembrane component domain Spea_2412 76 COG2717 COG2717, Predicted membrane protein Function unknown 157960840 Common - glutamate synthase, small subunit Spea_1012 192 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 157961906 Common - phospholipase D/transphosphatidylase Spea_2085 30 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 157962138 Common - hypothetical protein Spea_2317 6 None None None 157962344 Common - hypothetical protein Spea_2523 65 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 157961884 Common - Ribonucleoside-diphosphate reductase Spea_2063 152 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 157962524 Common - transcriptional regulator, CdaR Spea_2703 47 COG3835 CdaR, Sugar diacid utilization regulator Transcription / Signal transduction mechanisms 157960337 Common - Polysulphide reductase NrfD Spea_0508 26 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 157960777 Common - Ornithine carbamoyltransferase Spea_0949 198 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 157960067 Common - Shikimate kinase Spea_0238 201 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 157963089 Nonpathogen - hypothetical protein Spea_3273 2 None None None 157962265 Common - septum site-determining protein MinC Spea_2444 110 COG0850 MinC, Septum formation inhibitor Cell division and chromosome partitioning 157962390 Common - Prolyl oligopeptidase Spea_2569 118 COG1505 COG1505, Serine proteases of the peptidase family S9A Amino acid transport and metabolism 157961175 Common - flagellar P-ring protein Spea_1347 105 COG1706 FlgI, Flagellar basal-body P-ring protein Cell motility and secretion 157964009 Common - hypothetical protein Spea_4198 17 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 157961561 Common - hypothetical protein Spea_1737 96 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 157962430 Common - membrane protein involved in aromatic hydrocarbon degradation Spea_2609 71 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 157960353 Common - GCN5-related N-acetyltransferase Spea_0524 115 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 157962550 Common - cytochrome B561 Spea_2729 56 COG3658 COG3658, Cytochrome b Energy production and conversion 157962770 Common - YidE/YbjL duplication Spea_2952 58 COG2985 COG2985, Predicted permease General function prediction only 157962270 Common - alpha/beta hydrolase fold Spea_2449 122 COG2267 PldB, Lysophospholipase Lipid metabolism 157960669 Common - hypothetical protein Spea_0841 1 None None None 157962437 Common - GTP cyclohydrolase II Spea_2616 196 COG0807 RibA, GTP cyclohydrolase II Coenzyme metabolism 157960998 Common - transposase IS116/IS110/IS902 family protein Spea_1170 98 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 157959962 Common - Oligopeptidase B Spea_0132 100 COG1770 PtrB, Protease II Amino acid transport and metabolism 157962546 Nonpathogen - hypothetical protein Spea_2725 1 None None None 157963079 Common - hypothetical protein Spea_3262 2 None None None 157961428 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Spea_1602 31 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 157962251 Common - ATP-dependent helicase HrpA Spea_2430 131 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 157961050 Common - PepSY-associated TM helix domain protein Spea_1222 31 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 157961399 Common - NADH:ubiquinone oxidoreductase, subunit A Spea_1573 39 COG1726 NqrA, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA Energy production and conversion 157963884 Common - hypothetical protein Spea_4073 1 None None None 157962513 Common - cytochrome C family protein Spea_2692 34 None None None 157963219 Common - Na+ dependent nucleoside transporter domain protein Spea_3405 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 157962263 Common - lytic murein transglycosylase Spea_2442 102 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 157961155 Common - hypothetical protein Spea_1327 18 None None None 157960648 Common - Alkaline phosphatase Spea_0820 57 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 157961096 Common - hypothetical protein Spea_1268 9 None None None 157963589 Common - hypothetical protein Spea_3777 1 COG3170 FimV, Tfp pilus assembly protein FimV Cell motility and secretion / Intracellular trafficking and secretion 157961207 Common - response regulator receiver protein Spea_1379 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 157962926 Common - hypothetical protein Spea_3109 21 None None None 157961316 Common - iron-sulfur cluster assembly protein IscA Spea_1490 161 COG0316 IscA, Uncharacterized conserved protein Function unknown 157960938 Common - protein of unknown function DUF469 Spea_1110 26 COG3171 COG3171, Uncharacterized protein conserved in bacteria Function unknown 157963501 Common - chaperonin GroEL Spea_3689 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 157961803 Common - dihydrodipicolinate synthase Spea_1980 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 157963471 Common - response regulator receiver protein Spea_3659 2 None None None 157960892 Common - hypothetical protein Spea_1064 1 None None None 157963212 Common - polar amino acid ABC transporter, inner membrane subunit Spea_3398 179 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 157960828 Common - cobalamin biosynthesis protein CbiB Spea_1000 90 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 157960946 Common - transcriptional regulator, LysR family Spea_1118 66 COG0583 LysR, Transcriptional regulator Transcription 157960175 Common - amino acid-binding ACT domain protein Spea_0346 1 COG3978 COG3978, Acetolactate synthase (isozyme II), small (regulatory) subunit Function unknown 157963411 Nonpathogen - hypothetical protein Spea_3597 1 COG3105 COG3105, Uncharacterized protein conserved in bacteria Function unknown 157960504 Common - hypothetical protein Spea_0676 1 None None None 157961987 Common - protein of unknown function DUF1302 Spea_2166 18 None None None 157963376 Common - NUDIX hydrolase Spea_3562 98 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 157962623 Common - 3-oxoacid CoA-transferase, A subunit Spea_2803 103 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 157960533 Common - penicillin-binding protein 1B Spea_0705 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 157963349 Common - Cytochrome b/b6 domain Spea_3535 149 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 157961763 Common - BNR repeat protein Spea_1940 35 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 157961865 Common - iron-containing alcohol dehydrogenase Spea_2044 216 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 157962409 Common - Chorismate synthase Spea_2588 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 157963291 Common - (Glutamate--ammonia-ligase) adenylyltransferase Spea_3477 119 COG1391 GlnE, Glutamine synthetase adenylyltransferase Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms 157963673 Common - Dimethylsulfoxide reductase chain B Spea_3862 146 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 157961243 Common - RNA-metabolising metallo-beta-lactamase Spea_1417 122 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 157962171 Common - Rhomboid family protein Spea_2350 44 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 157961993 Common - Electron-transferring-flavoprotein dehydrogenase Spea_2172 110 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 157960237 Common - protein of unknown function DUF329 Spea_0408 58 COG3024 COG3024, Uncharacterized protein conserved in bacteria Function unknown 157960769 Common - aspartate racemase Spea_0941 86 COG1794 RacX, Aspartate racemase Cell envelope biogenesis, outer membrane 157960472 Nonpathogen - hypothetical protein Spea_0644 1 None None None 157960681 Common - ribosomal protein L27 Spea_0853 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 157963497 Common - NERD domain protein Spea_3685 7 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 157961690 Nonpathogen - hypothetical protein Spea_1866 1 None None None 157960622 Nonpathogen - hypothetical protein Spea_0794 1 None None None 157960885 Common - hypothetical protein Spea_1057 1 COG3671 COG3671, Predicted membrane protein Function unknown 157961074 Common - PEBP family protein Spea_1246 123 COG1881 COG1881, Phospholipid-binding protein General function prediction only 157960805 Common - TonB-dependent receptor Spea_0977 110 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 157960722 Common - transcriptional regulator, LysR family Spea_0894 187 COG0583 LysR, Transcriptional regulator Transcription 157960662 Common - Rh family protein/ammonium transporter Spea_0834 203 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 157962531 Nonpathogen - hypothetical protein Spea_2710 1 None None None 157962904 Common - Xanthine/uracil/vitamin C permease Spea_3086 134 COG2252 COG2252, Permeases General function prediction only 157961401 Common - NADH:ubiquinone oxidoreductase, subunit C Spea_1575 44 COG2869 NqrC, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC Energy production and conversion 157961815 Common - phosphoenolpyruvate-protein phosphotransferase Spea_1994 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 157960123 Nonpathogen - hypothetical protein Spea_0294 1 None None None 157963557 Common - secretion protein HlyD family protein Spea_3745 118 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 157963198 Common - Phosphoglycerate mutase Spea_3383 153 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 157961215 Common - hypothetical protein Spea_1387 13 None None None 157962740 Common - protein of unknown function DUF1568 Spea_2922 20 None None None 157963684 Common - protein of unknown function DUF159 Spea_3873 33 COG2135 COG2135, Uncharacterized conserved protein Function unknown 157961089 Nonpathogen - hypothetical protein Spea_1261 1 None None None 157963035 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Spea_3218 131 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 157961543 Common - transcriptional regulator, LysR family Spea_1719 181 COG0583 LysR, Transcriptional regulator Transcription 157962484 Common - anion transporter Spea_2663 174 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 157961029 Common - transcriptional regulator, LysR family Spea_1201 172 COG0583 LysR, Transcriptional regulator Transcription 157961704 Common - alpha/beta hydrolase fold Spea_1880 14 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 157960181 Common - sodium:neurotransmitter symporter Spea_0352 88 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 157959906 Common - SAF domain protein Spea_0076 23 COG1261 FlgA, Flagellar basal body P-ring biosynthesis protein Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 157962164 Common - SEC-C motif domain protein Spea_2343 88 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 157959835 Common - metal dependent phosphohydrolase Spea_0005 44 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 157963751 Common - transcriptional regulator, LysR family Spea_3940 108 COG0583 LysR, Transcriptional regulator Transcription 157961190 Common - flagellar motor switch protein FliG Spea_1362 125 COG1536 FliG, Flagellar motor switch protein Cell motility and secretion 157961101 Common - helicase domain protein Spea_1273 26 None None None 157962114 Nonpathogen - hypothetical protein Spea_2293 1 None None None 157963318 Common - hypothetical protein Spea_3504 7 None None None 157963187 Common - hypothetical protein Spea_3372 25 COG3247 HdeD, Uncharacterized conserved protein Function unknown 157963424 Common - Na+/Ca+ antiporter, CaCA family Spea_3610 124 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 157962986 Common - methyl-accepting chemotaxis sensory transducer Spea_3169 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157962712 Common - hypothetical protein Spea_2893 10 None None None 157959910 Common - ATPase, FliI/YscN family Spea_0080 247 COG1157 FliI, Flagellar biosynthesis/type III secretory pathway ATPase Cell motility and secretion / Intracellular trafficking and secretion 157961272 Common - UDP-glucose 4-epimerase Spea_1446 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 157962359 Common - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Spea_2538 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 157963414 Common - hypothetical protein Spea_3600 44 None None None 157962828 Common - putative signal transduction protein Spea_3010 47 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 157962178 Common - electron transport complex, RnfABCDGE type, G subunit Spea_2357 57 COG4659 RnfG, Predicted NADH:ubiquinone oxidoreductase, subunit RnfG Energy production and conversion 157960014 Common - ribosomal protein L3 Spea_0184 236 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 157963608 Common - twin-arginine translocation protein, TatB subunit Spea_3796 34 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 157963745 Common - histidine kinase Spea_3934 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157960079 Common - phosphoheptose isomerase Spea_0250 122 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 157963906 Common - binding-protein-dependent transport systems inner membrane component Spea_4095 180 COG4662 TupA, ABC-type tungstate transport system, periplasmic component Coenzyme metabolism 157963889 Common - YheO domain protein Spea_4078 48 COG2964 COG2964, Uncharacterized protein conserved in bacteria Function unknown 157960761 Common - hypothetical protein Spea_0933 36 None None None 157960911 Common - isoleucyl-tRNA synthetase Spea_1083 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 157963363 Common - phosphatidylserine decarboxylase Spea_3549 97 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 157964058 Common - ATP synthase I chain Spea_4247 36 COG3312 AtpI, F0F1-type ATP synthase, subunit I Energy production and conversion 157963929 Common - molybdenum cofactor biosynthesis protein C Spea_4118 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 157964063 Common - flavodoxin/nitric oxide synthase Spea_4252 78 COG0716 FldA, Flavodoxins Energy production and conversion 157964051 Common - ATP synthase F1, beta subunit Spea_4240 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 157960178 Common - threonine dehydratase, biosynthetic Spea_0349 226 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 157960638 Common - serine transporter Spea_0810 32 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 157962726 Common - Polyketide-type polyunsaturated fatty acid synthase, PfaA Spea_2907 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 157962895 Common - peptidylprolyl isomerase FKBP-type Spea_3077 131 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 157962030 Common - hypothetical protein Spea_2209 36 COG4430 COG4430, Uncharacterized protein conserved in bacteria Function unknown 157963112 Nonpathogen - hypothetical protein Spea_3296 1 None None None 157963826 Common - RNA binding S1 domain protein Spea_4015 215 COG2183 Tex, Transcriptional accessory protein Transcription 157963233 Common - major facilitator superfamily MFS_1 Spea_3419 74 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 157961599 Common - DSBA oxidoreductase Spea_1775 101 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 157963346 Common - Stringent starvation protein B Spea_3532 64 COG2969 SspB, Stringent starvation protein B General function prediction only 157961140 Common - exodeoxyribonuclease VII, large subunit Spea_1312 205 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 157963080 Common - hypothetical protein Spea_3263 8 None None None 157959919 Common - flagellar biosynthetic protein FliP Spea_0089 128 COG1338 FliP, Flagellar biosynthesis pathway, component FliP Cell motility and secretion / Intracellular trafficking and secretion 157961948 Common - hypothetical protein Spea_2127 41 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 157963046 Common - protein-P-II uridylyltransferase Spea_3229 122 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 157960257 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Spea_0428 180 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 157961324 Common - Nucleoside-diphosphate kinase Spea_1498 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 157962617 Common - transcriptional regulator, MerR family Spea_2796 54 COG0789 SoxR, Predicted transcriptional regulators Transcription 157962789 Common - putative exonuclease RdgC Spea_2971 53 COG2974 RdgC, DNA recombination-dependent growth factor C DNA replication, recombination, and repair 157963841 Common - transcriptional regulator, LysR family Spea_4030 138 COG0583 LysR, Transcriptional regulator Transcription 157963072 Common - Ankyrin Spea_3255 105 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 157961613 Common - 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase Spea_1789 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 157960296 Common - Endoribonuclease L-PSP Spea_0467 149 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 157960907 Common - transcriptional regulator, ArsR family Spea_1079 171 COG0640 ArsR, Predicted transcriptional regulators Transcription 157961824 Nonpathogen - hypothetical protein Spea_2003 1 None None None 157961652 Common - TonB-dependent receptor Spea_1828 110 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 157961657 Common - nitroreductase Spea_1833 82 COG0778 NfnB, Nitroreductase Energy production and conversion 157961798 Common - Lysine exporter protein (LYSE/YGGA) Spea_1975 82 COG1279 COG1279, Lysine efflux permease General function prediction only 157963652 Common - peptidase S9 prolyl oligopeptidase active site domain protein Spea_3841 118 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 157962940 Common - hypothetical protein Spea_3123 35 COG2912 COG2912, Uncharacterized conserved protein Function unknown 157960046 Common - TPR repeat-containing protein Spea_0217 56 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 157961494 Common - acetate kinase Spea_1669 162 COG0282 ackA, Acetate kinase Energy production and conversion 157963141 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Spea_3325 25 COG0748 HugZ, Putative heme iron utilization protein Inorganic ion transport and metabolism 157961317 Common - co-chaperone Hsc20 Spea_1491 56 COG1076 DjlA, DnaJ-domain-containing proteins 1 Posttranslational modification, protein turnover, chaperones 157962335 Common - diguanylate cyclase Spea_2514 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157963599 Common - hypothetical protein Spea_3787 22 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 157959970 Common - Phosphoenolpyruvate carboxykinase (ATP) Spea_0140 97 COG1866 PckA, Phosphoenolpyruvate carboxykinase (ATP) Energy production and conversion 157963535 Common - hypothetical protein Spea_3723 4 None None None 157962221 Common - sodium/hydrogen exchanger Spea_2400 123 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 157962826 Common - thioesterase superfamily protein Spea_3008 73 COG0824 FcbC, Predicted thioesterase General function prediction only 157960739 Common - permease YjgP/YjgQ family protein Spea_0911 86 COG0795 COG0795, Predicted permeases General function prediction only 157960218 Common - transcriptional regulator, Fis family Spea_0389 97 COG2901 Fis, Factor for inversion stimulation Fis, transcriptional activator Transcription / DNA replication, recombination, and repair 157960720 Common - LrgB family protein Spea_0892 83 COG1346 LrgB, Putative effector of murein hydrolase Cell envelope biogenesis, outer membrane 157961486 Common - ABC transporter related Spea_1661 249 COG4181 COG4181, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 157963601 Common - hypothetical protein Spea_3789 11 None None None 157960423 Common - peptidase S9 prolyl oligopeptidase active site domain protein Spea_0594 118 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 157960817 Common - Alkaline phosphatase Spea_0989 82 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 157960061 Common - penicillin-binding protein, 1A family Spea_0232 200 COG5009 MrcA, Membrane carboxypeptidase/penicillin-binding protein Cell envelope biogenesis, outer membrane 157960467 Common - Catalase Spea_0638 126 COG0753 KatE, Catalase Inorganic ion transport and metabolism 157960875 Common - cytochrome c assembly protein Spea_1047 61 COG4137 COG4137, ABC-type uncharacterized transport system, permease component General function prediction only 157962946 Common - 4-diphosphocytidyl-2C-methyl-D-erythritol kinase Spea_3129 193 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 157963403 Common - RNA methyltransferase, TrmH family, group 3 Spea_3589 215 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 157963161 Common - Hpt sensor hybrid histidine kinase Spea_3345 217 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157961481 Common - dihydrodipicolinate synthetase Spea_1655 154 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 157961129 Common - protein of unknown function DUF21 Spea_1301 219 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 157960856 Common - protein of unknown function DUF339 Spea_1028 46 COG2938 COG2938, Uncharacterized conserved protein Function unknown 157962643 Nonpathogen - hypothetical protein Spea_2823 1 None None None 157963311 Common - DEAD/DEAH box helicase domain protein Spea_3497 235 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 157963065 Common - FAD dependent oxidoreductase Spea_3248 33 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 157960923 Common - nitrogen regulatory protein P-II Spea_1095 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 157963117 Common - glycine dehydrogenase Spea_3301 172 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 157963386 Common - transcriptional regulator, LysR family Spea_3572 2 COG0583 LysR, Transcriptional regulator Transcription 157962602 Common - acyl-CoA dehydrogenase domain protein Spea_2781 165 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157960989 Common - ATP-cone domain protein Spea_1161 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 157961144 Common - Lytic transglycosylase catalytic Spea_1316 111 COG4623 COG4623, Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein Cell envelope biogenesis, outer membrane 157962253 Nonpathogen - hypothetical protein Spea_2432 1 None None None 157962503 Common - trigger factor Spea_2682 216 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 157960685 Common - Dihydrofolate reductase Spea_0857 147 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 157960538 Nonpathogen - hypothetical protein Spea_0710 1 None None None 157962666 Common - transposase IS116/IS110/IS902 family protein Spea_2847 63 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 157963468 Nonpathogen - hypothetical protein Spea_3656 1 None None None 157962014 Common - transporter, hydrophobe/amphiphile efflux-1 (HAE1) family Spea_2193 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 157960315 Common - periplasmic copper-binding Spea_0486 53 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 157962054 Common - cell divisionFtsK/SpoIIIE Spea_2233 199 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 157962930 Common - major facilitator superfamily MFS_1 Spea_3113 107 None None None 157962628 Common - efflux transporter, RND family, MFP subunit Spea_2808 162 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157962198 Common - response regulator receiver protein Spea_2377 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157963150 Common - transcriptional regulator, TetR family Spea_3334 6 COG1309 AcrR, Transcriptional regulator Transcription 157961300 Common - hypothetical protein Spea_1474 22 None None None 157960024 Common - ribosomal protein L14 Spea_0194 247 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 157961452 Common - transcriptional regulator, AraC family Spea_1626 121 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 157961142 Common - GMP synthase, large subunit Spea_1314 239 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 157960222 Common - fumarate reductase respiratory complex transmembrane subunit Spea_0393 10 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 157960833 Common - hypothetical protein Spea_1005 36 None None None 157963887 Common - Asp/Glu racemase Spea_4076 39 COG3473 COG3473, Maleate cis-trans isomerase Secondary metabolites biosynthesis, transport, and catabolism 157962515 Common - decaheme cytochrome c MtrF Spea_2694 8 None None None 157960929 Common - ATPase BadF/BadG/BcrA/BcrD type Spea_1101 60 COG2971 COG2971, Predicted N-acetylglucosamine kinase Carbohydrate transport and metabolism 157963077 Common - hypothetical protein Spea_3260 3 None None None 157962998 Common - Glutathione S-transferase domain Spea_3181 105 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 157961326 Common - transcriptional regulator, TraR/DksA family Spea_1500 7 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 157963792 Common - putative methyltransferase Spea_3981 189 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 157960488 Common - hypothetical protein Spea_0660 1 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 157960435 Common - sodium/hydrogen exchanger Spea_0606 203 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 157960627 Common - Integrase catalytic region Spea_0799 134 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157961779 Common - hypothetical protein Spea_1956 5 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 157961498 Common - hypothetical protein Spea_1673 9 None None None 157961382 Common - hypothetical protein Spea_1556 59 COG3034 COG3034, Uncharacterized protein conserved in bacteria Function unknown 157961847 Common - hydrogenase assembly chaperone hypC/hupF Spea_2026 79 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 157960590 Common - nitroreductase Spea_0762 55 COG0778 NfnB, Nitroreductase Energy production and conversion 157963252 Common - putative two component transcriptional regulator, winged helix family Spea_3438 1 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157960994 Common - NusB antitermination factor Spea_1166 197 COG0781 NusB, Transcription termination factor Transcription 157962678 Common - lipoprotein, putative Spea_2859 15 None None None 157961378 Common - secretion protein HlyD family protein Spea_1552 146 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 157960953 Common - protein of unknown function YGGT Spea_1125 93 COG0762 COG0762, Predicted integral membrane protein Function unknown 157963191 Common - cob(I)alamin adenosyltransferase Spea_3376 142 COG2109 BtuR, ATP:corrinoid adenosyltransferase Coenzyme metabolism 157962568 Common - diguanylate cyclase Spea_2747 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157963957 Common - protein of unknown function DUF890 Spea_4146 28 COG3129 COG3129, Predicted SAM-dependent methyltransferase General function prediction only 157960672 Common - extracellular solute-binding protein family 1 Spea_0844 108 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 157963442 Common - two component transcriptional regulator, winged helix family Spea_3630 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157961929 Common - DsrH family protein Spea_2108 11 COG2168 DsrH, Uncharacterized conserved protein involved in oxidation of intracellular sulfur Inorganic ion transport and metabolism 157962313 Common - Beta-ketoacyl synthase Spea_2492 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 157961506 Common - transcriptional regulator, TetR family Spea_1681 20 COG3226 COG3226, Uncharacterized protein conserved in bacteria Function unknown 157962026 Common - Threonine aldolase Spea_2205 94 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 157961310 Common - Inositol-phosphate phosphatase Spea_1484 215 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 157960563 Common - aspartate kinase Spea_0735 234 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 157963703 Common - Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ Spea_3892 23 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 157961026 Common - sodium pump decarboxylase, gamma subunit Spea_1198 5 COG3630 OadG, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, gamma subunit Energy production and conversion 157963133 Common - hypothetical protein Spea_3317 9 None None None 157960782 Common - hypothetical protein Spea_0954 50 COG2863 COG2863, Cytochrome c553 Energy production and conversion 157963576 Common - type II secretion system protein Spea_3764 145 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 157960254 Common - aconitate hydratase 2 Spea_0425 219 COG1049 AcnB, Aconitase B Energy production and conversion 157960789 Common - ribosomal protein S21 Spea_0961 99 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 157961692 Common - hypothetical protein Spea_1868 12 None None None 157961351 Common - recombination protein RecR Spea_1525 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 157962973 Common - lipoic acid synthetase Spea_3156 190 COG0320 LipA, Lipoate synthase Coenzyme metabolism 157962561 Common - HNH endonuclease Spea_2740 26 None None None 157962141 Common - 2-methylisocitrate dehydratase, Fe/S-dependent Spea_2320 223 COG1048 AcnA, Aconitase A Energy production and conversion 157962689 Common - DNA polymerase III, alpha subunit Spea_2870 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 157960950 Common - non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family Spea_1122 237 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 157961371 Common - lipoprotein releasing system, transmembrane protein, LolC/E family Spea_1545 220 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 157959858 Common - TrkA-N domain protein Spea_0028 144 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 157961772 Common - hypothetical protein Spea_1949 4 None None None 157962812 Common - L-lactate permease Spea_2994 104 COG1620 LldP, L-lactate permease Energy production and conversion 157963734 Common - Domain of unknown function DUF1864 Spea_3923 4 None None None 157960979 Common - transporter, hydrophobe/amphiphile efflux-1 (HAE1) family Spea_1151 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 157960631 Common - methyltransferase small Spea_0803 51 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 157959979 Common - general secretion pathway protein I Spea_0149 35 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 157960531 Common - 2'-5' RNA ligase Spea_0703 30 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 157963175 Common - PAS/PAC sensor signal transduction histidine kinase Spea_3360 216 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 157962281 Common - imidazoleglycerol phosphate synthase, glutamine amidotransferase subunit Spea_2460 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 157959876 Common - polysaccharide biosynthesis protein CapD Spea_0046 136 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 157961973 Common - protein of unknown function DUF35 Spea_2152 79 COG2030 MaoC, Acyl dehydratase Lipid metabolism 157960792 Common - protein of unknown function DUF205 Spea_0964 168 COG0344 COG0344, Predicted membrane protein Function unknown 157961116 Common - hypothetical protein Spea_1288 1 None None None 157960080 Common - protein of unknown function UPF0102 Spea_0251 125 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 157960750 Common - peptidase M24 Spea_0922 248 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 157962369 Common - FAD linked oxidase domain protein Spea_2548 202 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 157963260 Common - peptidase M16 domain protein Spea_3446 8 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 157963624 Common - UDP-N-acetylmuramoylalanine--D-glutamate ligase Spea_3813 211 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 157962696 Common - surface antigen (D15) Spea_2877 159 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 157962924 Common - rRNA (guanine-N(2)-)-methyltransferase Spea_3107 95 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 157962819 Common - cobalamin synthesis protein P47K Spea_3001 127 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 157961672 Common - hypothetical protein Spea_1848 28 None None None 157962508 Common - tRNA--hydroxylase Spea_2687 40 COG4445 MiaE, Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 157962035 Common - cytochrome c oxidase, cbb3-type, subunit I Spea_2214 152 COG3278 CcoN, Cbb3-type cytochrome oxidase, subunit 1 Posttranslational modification, protein turnover, chaperones 157961787 Common - glutaredoxin-like protein Spea_1964 126 COG0278 COG0278, Glutaredoxin-related protein Posttranslational modification, protein turnover, chaperones 157962499 Common - histone family protein DNA-binding protein Spea_2678 210 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 157960345 Common - Monosaccharide-transporting ATPase Spea_0516 166 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 157961679 Common - hypothetical protein Spea_1855 4 None None None 157963148 Common - transport system permease protein Spea_3332 185 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 157960326 Common - FNIP Spea_0497 18 None None None 157961791 Common - hypothetical protein Spea_1968 4 None None None 157960155 Common - transcriptional regulator, TetR family Spea_0326 3 COG1309 AcrR, Transcriptional regulator Transcription 157963278 Nonpathogen - hypothetical protein Spea_3464 1 None None None 157963135 Common - thiol:disulfide interchange protein, putative Spea_3319 48 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 157963267 Nonpathogen - hypothetical protein Spea_3453 1 None None None 157961192 Common - flagellar protein export ATPase FliI Spea_1364 247 COG1157 FliI, Flagellar biosynthesis/type III secretory pathway ATPase Cell motility and secretion / Intracellular trafficking and secretion 157961940 Common - flavin reductase domain protein FMN-binding Spea_2119 75 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 157962592 Common - ABC transporter related Spea_2771 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 157961254 Common - hypothetical protein Spea_1428 9 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 157961621 Common - Silent information regulator protein Sir2 Spea_1797 151 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 157962591 Common - hypothetical protein Spea_2770 19 None None None 157962703 Common - translation elongation factor Ts Spea_2884 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 157960587 Common - pseudouridine synthase Spea_0759 201 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 157962085 Nonpathogen - hypothetical protein Spea_2264 1 None None None 157960201 Common - Uroporphyrinogen III synthase HEM4 Spea_0372 73 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 157963018 Common - hypothetical protein Spea_3201 1 None None None 157960556 Common - inner-membrane translocator Spea_0728 134 COG1079 COG1079, Uncharacterized ABC-type transport system, permease component General function prediction only 157960826 Common - protein of unknown function UPF0126 Spea_0998 133 COG2860 COG2860, Predicted membrane protein Function unknown 157961049 Common - hypothetical protein Spea_1221 1 None None None 157960734 Common - hypothetical protein Spea_0906 12 None None None 157961501 Nonpathogen - hypothetical protein Spea_1676 2 COG3924 COG3924, Predicted membrane protein Function unknown 157963527 Common - periplasmic solute binding protein Spea_3715 88 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 157961357 Common - transferase hexapeptide repeat containing protein Spea_1531 183 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 157959842 Common - SirA family protein Spea_0012 92 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 157960466 Common - hypothetical protein Spea_0637 10 None None None 157960607 Common - GCN5-related N-acetyltransferase Spea_0779 5 None None None 157963565 Common - rod shape-determining protein MreC Spea_3753 108 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 157960422 Common - hypothetical protein Spea_0593 1 None None None 157963834 Common - DSBA oxidoreductase Spea_4023 32 None None None 157963563 Common - maf protein Spea_3751 196 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 157961261 Common - two component, sigma54 specific, transcriptional regulator, Fis family Spea_1435 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 157961222 Common - polysaccharide export protein Spea_1395 113 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 157963806 Common - aromatic amino acid transporter Spea_3995 41 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 157963861 Common - protein of unknown function DUF519 Spea_4050 86 COG2961 ComJ, Protein involved in catabolism of external DNA General function prediction only 157962412 Common - phosphohistidine phosphatase, SixA Spea_2591 47 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 157960005 Common - ribosomal protein L10 Spea_0175 206 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 157963649 Common - phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase Spea_3838 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 157962871 Common - peptide chain release factor 3 Spea_3053 249 COG4108 PrfC, Peptide chain release factor RF-3 Translation, ribosomal structure and biogenesis 157961764 Common - Patched family protein Spea_1941 102 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 157961360 Common - Succinylarginine dihydrolase Spea_1534 34 COG3724 AstB, Succinylarginine dihydrolase Amino acid transport and metabolism 157961216 Common - FlhB domain protein Spea_1388 90 COG2257 COG2257, Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB Function unknown 157963286 Common - hypothetical protein Spea_3472 2 None None None 157964042 Common - phosphate ABC transporter, ATPase subunit Spea_4231 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 157963259 Common - peptidase M16 domain protein Spea_3445 197 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 157961233 Common - nucleotidyl transferase Spea_1406 149 COG1213 COG1213, Predicted sugar nucleotidyltransferases Cell envelope biogenesis, outer membrane 157962956 Common - protein of unknown function UPF0054 Spea_3139 201 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 157961936 Common - major facilitator superfamily MFS_1 Spea_2115 24 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 157960242 Common - type IV-A pilus assembly ATPase PilB Spea_0413 223 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 157960249 Common - pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase Spea_0420 197 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 157963327 Common - hypothetical protein Spea_3513 18 None None None 157961017 Common - tRNA pseudouridine synthase D TruD Spea_1189 85 COG0585 COG0585, Uncharacterized conserved protein Function unknown 157960920 Common - hypothetical protein Spea_1092 1 None None None 157963101 Common - NADH dehydrogenase (quinone) Spea_3285 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 157963998 Common - hypothetical protein Spea_4187 1 None None None 157960091 Nonpathogen - hypothetical protein Spea_0262 1 None None None 157961894 Common - ribosomal protein S1 Spea_2073 216 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 157963355 Common - tRNA delta(2)-isopentenylpyrophosphate transferase Spea_3541 213 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 157960654 Common - SlyX family protein Spea_0826 27 COG2900 SlyX, Uncharacterized protein conserved in bacteria Function unknown 157962328 Common - 2OG-Fe(II) oxygenase Spea_2507 54 COG3491 PcbC, Isopenicillin N synthase and related dioxygenases General function prediction only 157963512 Nonpathogen - hypothetical protein Spea_3700 1 None None None 157962755 Common - hypothetical protein Spea_2937 33 None None None 157962101 Common - hypothetical protein Spea_2280 36 COG4628 COG4628, Uncharacterized conserved protein Function unknown 157962018 Common - diguanylate cyclase Spea_2197 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157962882 Common - Triose-phosphate isomerase Spea_3064 217 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 157962981 Common - ATPase AAA-2 domain protein Spea_3164 217 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 157963762 Common - Methyltransferase type 11 Spea_3951 32 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 157960264 Common - DSBA oxidoreductase Spea_0435 57 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 157961919 Common - putative orphan protein Spea_2098 5 None None None 157962151 Common - Integrase catalytic region Spea_2330 134 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157961838 Common - TadE family protein Spea_2017 5 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 157963991 Common - 2,3-diketo-5-methylthio-1-phosphopentane phosphatase Spea_4180 31 COG4229 COG4229, Predicted enolase-phosphatase Energy production and conversion 157960223 Common - succinate dehydrogenase or fumarate reductase, flavoprotein subunit Spea_0394 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 157961682 Common - hypothetical protein Spea_1858 17 None None None 157960078 Common - transport-associated Spea_0249 61 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 157963865 Common - Lytic transglycosylase catalytic Spea_4054 174 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 157962860 Common - alpha/beta hydrolase fold Spea_3042 12 COG4757 COG4757, Predicted alpha/beta hydrolase General function prediction only 157962936 Common - hypothetical protein Spea_3119 25 None None None 157961122 Common - transcriptional regulator, CopG family Spea_1294 3 None None None 157963694 Common - Na+/Ca+ antiporter, CaCA family Spea_3883 124 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 157963057 Common - Glutathione S-transferase domain Spea_3240 96 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 157961577 Common - MaoC domain protein dehydratase Spea_1753 68 COG2030 MaoC, Acyl dehydratase Lipid metabolism 157960144 Common - hypothetical protein Spea_0315 4 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 157960957 Common - twitching motility protein Spea_1129 192 COG5008 PilU, Tfp pilus assembly protein, ATPase PilU Cell motility and secretion / Intracellular trafficking and secretion 157960146 Common - hypothetical protein Spea_0317 9 None None None 157960551 Common - alpha/beta hydrolase fold Spea_0723 33 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 157960703 Common - hypothetical protein Spea_0875 4 None None None 157962544 Nonpathogen - hypothetical protein Spea_2723 5 None None None 157962688 Common - tRNA(Ile)-lysidine synthetase Spea_2869 211 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 157960494 Common - Adenylyl-sulfate kinase Spea_0666 145 COG0529 CysC, Adenylylsulfate kinase and related kinases Inorganic ion transport and metabolism 157961805 Common - efflux transporter, RND family, MFP subunit Spea_1982 172 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157962191 Common - protein of unknown function DUF785 Spea_2370 34 COG4067 COG4067, Uncharacterized protein conserved in archaea Posttranslational modification, protein turnover, chaperones 157960812 Common - hypothetical protein Spea_0984 19 None None None 157963098 Common - Na+/H+ antiporter MnhB subunit-related protein Spea_3282 44 COG2111 MnhB, Multisubunit Na+/H+ antiporter, MnhB subunit Inorganic ion transport and metabolism 157961910 Common - histidine kinase Spea_2089 219 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 157963398 Common - ribosomal protein S18 Spea_3584 214 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 157960448 Nonpathogen - hypothetical protein Spea_0619 1 None None None 157961831 Common - peptidase A24A prepilin type IV Spea_2010 24 COG4960 CpaA, Flp pilus assembly protein, protease CpaA Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 157963812 Common - cytochrome c oxidase assembly protein CtaG/Cox11 Spea_4001 68 COG3175 COX11, Cytochrome oxidase assembly factor Posttranslational modification, protein turnover, chaperones 157962845 Common - DEAD/DEAH box helicase domain protein Spea_3027 237 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 157962780 Common - YfaZ family protein Spea_2962 10 None None None 157961090 Common - hypothetical protein Spea_1262 41 COG2378 COG2378, Predicted transcriptional regulator Transcription 157961758 Common - carboxyl-terminal protease Spea_1935 181 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 157961532 Common - amine oxidase Spea_1707 77 COG2907 COG2907, Predicted NAD/FAD-binding protein General function prediction only 157960343 Common - RbsD or FucU transport Spea_0514 44 COG1869 RbsD, ABC-type ribose transport system, auxiliary component Carbohydrate transport and metabolism 157959923 Common - flagellar biosynthesis protein FlhA Spea_0093 127 COG1298 FlhA, Flagellar biosynthesis pathway, component FlhA Cell motility and secretion / Intracellular trafficking and secretion 157963665 Common - transcriptional regulator, LysR family Spea_3854 159 COG0583 LysR, Transcriptional regulator Transcription 157963785 Common - O-succinylbenzoate-CoA ligase Spea_3974 213 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 157962763 Common - protein of unknown function DUF633 Spea_2945 6 COG2384 COG2384, Predicted SAM-dependent methyltransferase General function prediction only 157963714 Common - Beta-ketoacyl synthase Spea_3903 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 157962697 Common - putative membrane-associated zinc metalloprotease Spea_2878 214 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 157963455 Common - binding-protein-dependent transport systems inner membrane component Spea_3643 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 157962183 Common - Holliday junction DNA helicase RuvB Spea_2362 238 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 157960857 Common - hypothetical protein Spea_1029 1 None None None 157961524 Common - hypothetical protein Spea_1699 3 None None None 157963091 Common - sulfatase Spea_3275 48 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 157963184 Common - phenylalanine/histidine ammonia-lyase Spea_3369 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 157963168 Common - membrane-flanked domain Spea_3352 31 COG3428 COG3428, Predicted membrane protein Function unknown 157961432 Common - Beta-ketoacyl synthase Spea_1606 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 157963228 Common - NADH dehydrogenase Spea_3414 188 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 157963944 Common - molybdopterin oxidoreductase Spea_4133 189 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 157961626 Common - aminotransferase class I and II Spea_1802 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 157961369 Common - transcription-repair coupling factor Spea_1543 238 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 157961419 Common - putative nitrogen regulatory protein P-II Spea_1593 12 None None None 157962559 Common - conserved hypothetical methyl-accepting chemotaxis protein Spea_2738 3 None None None 157961747 Common - DNA polymerase III, delta prime subunit Spea_1924 215 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 157963541 Common - hypothetical protein Spea_3729 1 None None None 157963397 Common - ribosomal protein L9 Spea_3583 212 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 157962589 Common - major facilitator superfamily MFS_1 Spea_2768 173 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 157963936 Common - PfkB domain protein Spea_4125 4 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 157960599 Common - aromatic amino acid permease Spea_0771 33 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 157961586 Nonpathogen - hypothetical protein Spea_1762 1 None None None 157960898 Common - apurinic endonuclease Apn1 Spea_1070 98 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 157963878 Common - hypothetical protein Spea_4067 1 None None None 157960522 Common - 3-methyl-2-oxobutanoate hydroxymethyltransferase Spea_0694 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 157960376 Common - hypothetical protein Spea_0547 14 None None None 157962073 Common - NADH:flavin oxidoreductase/NADH oxidase Spea_2252 197 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 157960116 Common - hypothetical protein Spea_0287 13 None None None 157962947 Common - ribose-phosphate pyrophosphokinase Spea_3130 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 157960305 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Spea_0476 148 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 157962887 Common - protein of unknown function UPF0044 Spea_3069 97 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 157962361 Common - adenylosuccinate lyase Spea_2540 232 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 157962960 Common - leucyl-tRNA synthetase Spea_3143 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 157963655 Common - ribonuclease PH Spea_3844 186 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 157961719 Nonpathogen - hypothetical protein Spea_1896 1 None None None 157961293 Common - pseudouridine synthase Spea_1467 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 157961003 Common - transcriptional regulator, LysR family Spea_1175 165 COG0583 LysR, Transcriptional regulator Transcription 157962655 Common - tetratricopeptide TPR_2 repeat protein Spea_2835 21 None None None 157960865 Common - Ribonuclease III Spea_1037 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 157961635 Common - nitrite reductase (NAD(P)H), large subunit Spea_1811 200 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 157963917 Common - hypothetical protein Spea_4106 17 None None None 157959931 Common - GTP-binding protein HSR1-related Spea_0101 176 COG0218 COG0218, Predicted GTPase General function prediction only 157962043 Common - transcriptional regulator, Crp/Fnr family Spea_2222 163 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 157960090 Common - Aldehyde ferredoxin oxidoreductase Spea_0261 55 COG2414 COG2414, Aldehyde:ferredoxin oxidoreductase Energy production and conversion 157961008 Common - Hpt sensor hybrid histidine kinase Spea_1180 226 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157963305 Common - methyl-accepting chemotaxis sensory transducer with Cache sensor Spea_3491 157 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157962205 Common - hypothetical protein Spea_2384 1 None None None 157960054 Common - Phosphoenolpyruvate carboxylase Spea_0225 118 COG2352 Ppc, Phosphoenolpyruvate carboxylase Energy production and conversion 157961469 Common - cytochrome c family protein Spea_1643 20 None None None 157960578 Common - hypothetical protein Spea_0750 7 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 157960606 Common - diguanylate cyclase Spea_0778 8 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157961030 Common - Agmatine deiminase Spea_1202 87 COG2957 COG2957, Peptidylarginine deiminase and related enzymes Amino acid transport and metabolism 157961891 Common - Aspartate transaminase Spea_2070 75 COG1448 TyrB, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 157961840 Common - type II secretion system protein E Spea_2019 159 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 157960133 Common - TonB-dependent receptor Spea_0304 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 157961753 Common - Paraquat-inducible protein A Spea_1930 54 COG2995 PqiA, Uncharacterized paraquat-inducible protein A Function unknown 157961844 Common - hydrogenase expression/synthesis HypA Spea_2023 63 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 157961538 Common - transposase and inactivated derivative Spea_1714 8 None None None 157960784 Common - cytochrome C oxidase mono-heme subunit/FixO Spea_0956 82 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 157960701 Common - secretion protein HlyD family protein Spea_0873 110 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 157961167 Common - MCP methyltransferase, CheR-type Spea_1339 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 157961859 Common - hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit Spea_2038 148 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 157961160 Common - hypothetical protein Spea_1332 12 None None None 157960283 Common - transcriptional regulator, LysR family Spea_0454 126 COG0583 LysR, Transcriptional regulator Transcription 157962226 Common - Methyltransferase type 11 Spea_2405 54 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 157960148 Common - hypothetical protein Spea_0319 6 None None None 157962621 Common - Carbamoyl-phosphate synthase L chain ATP-binding Spea_2800 236 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 157961424 Common - glutaredoxin Spea_1598 20 COG2999 GrxB, Glutaredoxin 2 Posttranslational modification, protein turnover, chaperones 157961249 Common - nucleotidyl transferase Spea_1423 61 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 157962340 Common - histidine kinase Spea_2519 216 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157963875 Common - hypothetical protein Spea_4064 21 COG0824 FcbC, Predicted thioesterase General function prediction only 157959912 Common - flagellar motor switch protein FliG Spea_0082 122 COG1536 FliG, Flagellar motor switch protein Cell motility and secretion 157960081 Common - LppC family lipoprotein Spea_0252 41 COG3107 LppC, Putative lipoprotein General function prediction only 157961722 Common - integrase family protein Spea_1899 16 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 157959964 Common - signal peptidase I Spea_0134 209 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 157963845 Common - Enoyl-CoA hydratase/isomerase Spea_4034 178 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 157961040 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Spea_1212 152 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 157962807 Common - exodeoxyribonuclease VII, small subunit Spea_2989 112 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 157961706 Common - hypothetical protein Spea_1882 12 COG2515 Acd, 1-aminocyclopropane-1-carboxylate deaminase Amino acid transport and metabolism 157961240 Common - DegT/DnrJ/EryC1/StrS aminotransferase Spea_1413 196 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 157961193 Common - flagellar export protein FliJ Spea_1365 39 COG2882 FliJ, Flagellar biosynthesis chaperone Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 157962260 Common - Na+/H+ antiporter NhaB Spea_2439 29 COG3067 NhaB, Na+/H+ antiporter Inorganic ion transport and metabolism 157960524 Common - poly(A) polymerase Spea_0696 213 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 157962464 Common - GCN5-related N-acetyltransferase Spea_2643 91 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 157962526 Common - OmpA/MotB domain protein Spea_2705 141 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 157962279 Common - histidinol-phosphate aminotransferase Spea_2458 229 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 157959833 Common - DNA replication and repair protein RecF Spea_0003 168 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 157961405 Common - NADH:ubiquinone oxidoreductase, subunit F Spea_1579 17 COG2871 NqrF, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF Energy production and conversion 157963353 Common - small GTP-binding protein Spea_3539 232 COG2262 HflX, GTPases General function prediction only 157962815 Common - protein of unknown function DUF162 Spea_2997 97 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 157960960 Common - protein of unknown function DUF179 Spea_1132 131 COG1678 COG1678, Putative transcriptional regulator Transcription 157962373 Common - GCN5-related N-acetyltransferase Spea_2552 82 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 157961908 Nonpathogen - hypothetical protein Spea_2087 1 None None None 157962772 Common - Antibiotic biosynthesis monooxygenase Spea_2954 36 COG1359 COG1359, Uncharacterized conserved protein Function unknown 157960673 Common - binding-protein-dependent transport systems inner membrane component Spea_0845 199 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 157960307 Common - cytochrome c-type biogenesis protein CcmF Spea_0478 131 COG1138 CcmF, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 157960618 Common - Phosphoglycerate kinase Spea_0790 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 157962548 Common - phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I Spea_2727 238 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 157960759 Common - hypothetical protein Spea_0931 1 None None None 157961094 Nonpathogen - hypothetical protein Spea_1266 3 None None None 157963461 Common - diguanylate cyclase/phosphodiesterase Spea_3649 178 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 157964012 Common - ABC-2 type transporter Spea_4201 156 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 157962638 Common - anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family Spea_2818 170 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 157962607 Common - short-chain dehydrogenase/reductase SDR Spea_2786 136 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 157959884 Common - hypothetical protein Spea_0054 1 None None None 157959892 Common - flagellar hook-associated 2 domain protein Spea_0062 97 COG1345 FliD, Flagellar capping protein Cell motility and secretion 157962308 Common - Exodeoxyribonuclease I Spea_2487 51 COG2925 SbcB, Exonuclease I DNA replication, recombination, and repair 157962272 Common - hypothetical protein Spea_2451 7 None None None 157959937 Common - 2-amino-3-ketobutyrate coenzyme A ligase Spea_0107 192 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 157963063 Common - Mandelate racemase/muconate lactonizing protein Spea_3246 115 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 157960996 Common - phosphatidylglycerophosphatase A Spea_1168 105 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 157961385 Nonpathogen - hypothetical protein Spea_1559 1 None None None 157963476 Nonpathogen - hypothetical protein Spea_3664 3 None None None 157960335 Common - tetratricopeptide TPR_2 repeat protein Spea_0506 18 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 157963619 Common - cell division protein FtsA Spea_3808 187 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 157961104 Common - hypothetical protein Spea_1276 3 None None None 157960385 Common - transcriptional regulator, LysR family Spea_0556 174 COG0583 LysR, Transcriptional regulator Transcription 157961727 Common - lytic murein transglycosylase Spea_1904 111 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 157962008 Common - Amidohydrolase 3 Spea_2187 72 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 157960429 Common - protein of unknown function DUF558 Spea_0600 205 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 157963024 Nonpathogen - hypothetical protein Spea_3207 5 None None None 157963494 Common - protein of unknown function DUF1568 Spea_3682 17 None None None 157960318 Common - transcriptional regulator, CadC Spea_0489 6 COG3710 CadC, DNA-binding winged-HTH domains Transcription 157963690 Common - (p)ppGpp synthetase I, SpoT/RelA Spea_3879 207 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 157961801 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Spea_1978 203 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 157960506 Common - hypothetical protein Spea_0678 8 None None None 157962720 Common - Syd family protein Spea_2901 19 None None None 157963724 Common - pyridoxal kinase Spea_3913 56 COG2240 PdxK, Pyridoxal/pyridoxine/pyridoxamine kinase Coenzyme metabolism 157962218 Common - putative serine transporter Spea_2397 32 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 157962461 Common - serine/threonine protein kinase Spea_2640 5 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 157964020 Common - transcriptional regulator, LysR family Spea_4209 188 COG0583 LysR, Transcriptional regulator Transcription 157959838 Common - DNA-3-methyladenine glycosylase I Spea_0008 132 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 157964027 Common - Rhodanese domain protein Spea_4216 155 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 157961593 Common - DNA internalization-related competence protein ComEC/Rec2 Spea_1769 131 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 157960259 Common - hypothetical protein Spea_0430 3 None None None 157963173 Common - aldehyde dehydrogenase Spea_3357 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 157960232 Common - Integrase catalytic region Spea_0403 142 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157962418 Common - hypothetical protein Spea_2597 1 None None None 157961364 Common - L-serine dehydratase 1 Spea_1538 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 157961775 Common - peptidase S16 lon domain protein Spea_1952 137 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 157963365 Common - MscS Mechanosensitive ion channel Spea_3551 217 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 157963965 Common - protein of unknown function DUF833 Spea_4154 48 COG3332 COG3332, Uncharacterized conserved protein Function unknown 157960396 Common - peptidase M28 Spea_0567 62 COG2234 Iap, Predicted aminopeptidases General function prediction only 157961923 Common - hypothetical protein Spea_2102 7 None None None 157962767 Common - sodium:dicarboxylate symporter Spea_2949 163 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 157961397 Common - band 7 protein Spea_1571 211 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 157960136 Common - hypothetical protein Spea_0307 1 None None None 157963537 Common - hypothetical protein Spea_3725 14 None None None 157963334 Nonpathogen - hypothetical protein Spea_3520 2 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 157961462 Common - protein of unknown function DUF1097 Spea_1636 13 None None None 157962399 Common - phosphoribosylglycinamide formyltransferase Spea_2578 222 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 157960398 Common - excinuclease ABC, A subunit Spea_0569 236 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 157960766 Common - transcriptional regulator, MerR family Spea_0938 27 COG0789 SoxR, Predicted transcriptional regulators Transcription 157960542 Common - hypothetical protein Spea_0714 8 None None None 157962731 Common - hypothetical protein Spea_2913 3 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 157961655 Common - aminoglycoside phosphotransferase Spea_1831 3 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 157963704 Common - glycosyl transferase family 2 Spea_3893 133 COG4261 COG4261, Predicted acyltransferase General function prediction only 157959861 Common - peptide deformylase Spea_0031 214 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 157962825 Common - OsmC family protein Spea_3007 16 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 157961522 Common - putative CBS domain and cyclic nucleotide-regulated nucleotidyltransferase Spea_1697 109 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 157962890 Common - hypothetical protein Spea_3072 3 None None None 157962095 Common - GCN5-related N-acetyltransferase Spea_2274 32 COG0456 RimI, Acetyltransferases General function prediction only 157960660 Common - isochorismatase hydrolase Spea_0832 80 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 157962571 Common - hypothetical protein Spea_2750 3 None None None 157959846 Common - transposase Spea_0016 9 None None None 157963303 Common - SH3 type 3 domain protein Spea_3489 33 COG3103 COG3103, SH3 domain protein Signal transduction mechanisms 157961938 Common - Acetaldehyde dehydrogenase Spea_2117 37 COG4569 MhpF, Acetaldehyde dehydrogenase (acetylating) Secondary metabolites biosynthesis, transport, and catabolism 157961545 Common - hypothetical protein Spea_1721 1 None None None 157962012 Common - secretion protein HlyD family protein Spea_2191 145 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 157962533 Common - hypothetical protein Spea_2712 2 None None None 157962472 Common - MotA/TolQ/ExbB proton channel Spea_2651 134 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 157961833 Common - SAF domain protein Spea_2012 60 COG3745 CpaB, Flp pilus assembly protein CpaB Intracellular trafficking and secretion 157960125 Common - hypothetical protein Spea_0296 9 None None None 157961873 Common - CopG domain protein DNA-binding domain protein Spea_2052 21 None None None 157963799 Common - efflux transporter, RND family, MFP subunit Spea_3988 148 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157962443 Common - Alcohol dehydrogenase zinc-binding domain protein Spea_2622 139 COG2130 COG2130, Putative NADP-dependent oxidoreductases General function prediction only 157961738 Common - transposase Spea_1915 9 None None None 157962326 Common - sulphate transporter Spea_2505 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 157959942 Nonpathogen - hypothetical protein Spea_0112 3 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 157963671 Common - hypothetical protein Spea_3860 5 None None None 157963120 Common - Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family Spea_3304 136 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 157961454 Common - putative alpha-glucosidase Spea_1628 18 None None None 157962131 Nonpathogen - hypothetical protein Spea_2310 1 None None None 157962486 Common - hypothetical protein Spea_2665 28 COG3768 COG3768, Predicted membrane protein Function unknown 157960012 Common - translation elongation factor Tu Spea_0182 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 157962865 Common - thymidine phosphorylase Spea_3047 118 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 157960279 Common - hypothetical protein Spea_0450 5 None None None 157963614 Common - preprotein translocase, SecA subunit Spea_3803 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 157960167 Common - phenylalanine/histidine ammonia-lyase Spea_0338 109 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 157962383 Common - Tol-Pal system YbgF Spea_2562 99 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 157964068 Common - 60 kDa inner membrane insertion protein Spea_4257 214 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 157961470 Common - PHP domain protein Spea_1644 133 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 157960478 Common - NAD(P)(+) transhydrogenase (AB-specific) Spea_0650 123 COG1282 PntB, NAD/NADP transhydrogenase beta subunit Energy production and conversion 157962243 Common - D-alanine--D-alanine ligase Spea_2422 207 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 157961615 Common - succinyl-CoA synthetase, alpha subunit Spea_1791 217 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 157962984 Common - putative lipoprotein Spea_3167 125 COG4105 ComL, DNA uptake lipoprotein General function prediction only 157960019 Common - ribosomal protein L22 Spea_0189 218 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 157962094 Nonpathogen - hypothetical protein Spea_2273 1 None None None 157963316 Common - hypothetical protein Spea_3502 1 COG5589 COG5589, Uncharacterized conserved protein Function unknown 157963422 Common - protein of unknown function DUF140 Spea_3608 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 157959909 Common - hypothetical protein Spea_0079 1 None None None 157961274 Common - phenylalanine-4-hydroxylase Spea_1448 45 COG3186 COG3186, Phenylalanine-4-hydroxylase Amino acid transport and metabolism 157960683 Common - protein of unknown function DUF1212 Spea_0855 44 COG2966 COG2966, Uncharacterized conserved protein Function unknown 157960017 Common - ribosomal protein L2 Spea_0187 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 157963015 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Spea_3198 55 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 157961410 Common - Arylsulfotransferase Spea_1584 10 None None None 157959986 Common - NUDIX hydrolase Spea_0156 131 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 157961638 Common - serine/threonine protein kinase Spea_1814 146 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 157961825 Common - transcriptional regulator, XRE family Spea_2004 8 COG1396 HipB, Predicted transcriptional regulators Transcription 157964061 Common - methyltransferase GidB Spea_4250 197 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 157961611 Common - succinate dehydrogenase and fumarate reductase iron-sulfur protein Spea_1787 195 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 157963828 Common - two component transcriptional regulator, winged helix family Spea_4017 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157961086 Common - hypothetical protein Spea_1258 1 None None None 157960709 Common - GCN5-related N-acetyltransferase Spea_0881 87 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 157961990 Common - MaoC domain protein dehydratase Spea_2169 63 COG2030 MaoC, Acyl dehydratase Lipid metabolism 157960412 Common - Protein-disulfide reductase Spea_0583 166 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 157962424 Common - von Willebrand factor type A Spea_2603 79 COG2304 COG2304, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 157960361 Common - short-chain dehydrogenase/reductase SDR Spea_0532 159 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 157963382 Common - phage shock protein C, PspC Spea_3568 1 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 157962897 Common - chaperone protein DnaJ Spea_3079 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 157961266 Common - 3'(2'),5'-bisphosphate nucleotidase Spea_1440 186 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 157961812 Common - succinyl-diaminopimelate desuccinylase Spea_1991 208 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 157960439 Nonpathogen - hypothetical protein Spea_0610 2 None None None 157963822 Common - peptidase M14 carboxypeptidase A Spea_4011 18 None None None 157962037 Common - Cbb3-type cytochrome oxidase component Spea_2216 17 COG4736 CcoQ, Cbb3-type cytochrome oxidase, subunit 3 Posttranslational modification, protein turnover, chaperones 157960333 Common - Rhodanese domain protein Spea_0504 10 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 157963858 Common - protein of unknown function DUF548 Spea_4047 51 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 157963574 Common - methylation site containing protein Spea_3762 8 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 157963911 Common - membrane-fusion protein Spea_4100 9 None None None 157961283 Common - ABC transporter related Spea_1457 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 157963709 Common - tryptophan halogenase Spea_3898 92 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 157960160 Common - EAL domain protein Spea_0331 161 COG4943 COG4943, Predicted signal transduction protein containing sensor and EAL domains Signal transduction mechanisms 157960842 Common - conserved hypothetical radical SAM protein Spea_1014 97 COG1242 COG1242, Predicted Fe-S oxidoreductase General function prediction only 157962800 Common - protein of unknown function DUF423 Spea_2982 75 COG2363 COG2363, Uncharacterized small membrane protein Function unknown 157963948 Common - molybdopterin oxidoreductase Spea_4137 190 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 157961878 Common - hypothetical protein Spea_2057 9 None None None 157961080 Nonpathogen - hypothetical protein Spea_1252 1 None None None 157959868 Common - Coproporphyrinogen oxidase Spea_0038 113 COG0408 HemF, Coproporphyrinogen III oxidase Coenzyme metabolism 157961279 Common - transcriptional regulator, LysR family Spea_1453 192 COG0583 LysR, Transcriptional regulator Transcription 157962619 Common - Propionyl-CoA carboxylase Spea_2798 144 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 157959904 Common - flagellar basal-body rod protein FlgC Spea_0074 123 COG1558 FlgC, Flagellar basal body rod protein Cell motility and secretion 157963082 Common - methyl-accepting chemotaxis sensory transducer Spea_3266 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157962258 Common - protein of unknown function DUF490 Spea_2437 85 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 157963033 Nonpathogen - hypothetical protein Spea_3216 2 None None None 157963164 Common - hypothetical protein Spea_3348 28 None None None 157961708 Common - hypothetical protein Spea_1884 2 None None None 157962176 Common - electron transport complex, RnfABCDGE type, C subunit Spea_2355 75 COG4656 RnfC, Predicted NADH:ubiquinone oxidoreductase, subunit RnfC Energy production and conversion 157962337 Common - LPXTG-motif cell wall anchor domain Spea_2516 41 COG2425 COG2425, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 157960602 Common - hypothetical protein Spea_0774 1 None None None 157962435 Common - hypothetical protein Spea_2614 37 COG4628 COG4628, Uncharacterized conserved protein Function unknown 157963752 Common - Quinone oxidoreductase putative YhdH/YhfP Spea_3941 107 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 157963214 Common - transcriptional regulator, LysR family Spea_3400 161 COG0583 LysR, Transcriptional regulator Transcription 157961153 Common - efflux transporter, RND family, MFP subunit Spea_1325 160 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157962295 Nonpathogen - hypothetical protein Spea_2474 1 None None None 157963070 Common - protein of unknown function DUF181 Spea_3253 53 COG1944 COG1944, Uncharacterized conserved protein Function unknown 157962088 Common - riboflavin synthase, alpha subunit Spea_2267 208 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 157962120 Common - two component transcriptional regulator, LuxR family Spea_2299 217 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 157962586 Common - UspA domain protein Spea_2765 38 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 157962937 Common - AbgT putative transporter Spea_3120 39 COG2978 AbgT, Putative p-aminobenzoyl-glutamate transporter Coenzyme metabolism 157963255 Common - DSBA oxidoreductase Spea_3441 39 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 157961213 Common - CheW protein Spea_1385 14 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 157961564 Common - hypothetical protein Spea_1740 52 None None None 157963243 Common - transcriptional regulator, LysR family Spea_3429 192 COG0583 LysR, Transcriptional regulator Transcription 157961443 Common - tRNA pseudouridine synthase A Spea_1617 236 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 157963680 Common - putative outer membrane adhesin like proteiin Spea_3869 113 None None None 157961052 Common - sigma 54 modulation protein/ribosomal protein S30EA Spea_1224 57 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 157962267 Common - cell division topological specificity factor MinE Spea_2446 77 COG0851 MinE, Septum formation topological specificity factor Cell division and chromosome partitioning 157960943 Nonpathogen - hypothetical protein Spea_1115 1 None None None 157963499 Common - hypothetical protein Spea_3687 6 None None None 157960378 Common - pseudouridine synthase Spea_0549 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 157960623 Common - hypothetical protein Spea_0795 8 None None None 157963631 Common - MraZ protein Spea_3820 139 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 157962914 Common - ApbE family lipoprotein Spea_3097 139 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 157963778 Common - formate-dependent nitrite reductase Spea_3967 19 None None None 157962283 Common - imidazoleglycerol phosphate synthase, cyclase subunit Spea_2462 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 157961951 Common - ferredoxin Spea_2130 159 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 157961062 Common - Protein of unknown function DUF1974 Spea_1234 150 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157959990 Common - Rhodanese domain protein Spea_0160 65 COG2603 COG2603, Predicted ATPase General function prediction only 157960936 Common - A/G-specific adenine glycosylase Spea_1108 232 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 157961479 Common - transposase IS116/IS110/IS902 family protein Spea_1653 63 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 157960941 Common - transcriptional regulator, LysR family Spea_1113 188 COG0583 LysR, Transcriptional regulator Transcription 157960948 Common - protein of unknown function DUF885 Spea_1120 44 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 157962572 Common - glycoside hydrolase family 16 Spea_2751 14 COG2273 SKN1, Beta-glucanase/Beta-glucan synthetase Carbohydrate transport and metabolism 157960239 Common - dephospho-CoA kinase Spea_0410 209 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 157963503 Common - MATE efflux family protein Spea_3691 134 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 157963492 Nonpathogen - hypothetical protein Spea_3680 1 None None None 157962798 Common - Isocitrate dehydrogenase (NAD(+)) Spea_2980 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 157960868 Common - pyridoxal phosphate biosynthetic protein PdxJ Spea_1040 139 COG0854 PdxJ, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 157961860 Common - peptidase S9 prolyl oligopeptidase active site domain protein Spea_2039 111 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 157961069 Common - hypothetical protein Spea_1241 31 COG3528 COG3528, Uncharacterized protein conserved in bacteria Function unknown 157960535 Common - major facilitator superfamily MFS_1 Spea_0707 111 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 157961558 Common - histidine kinase Spea_1734 141 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 157962129 Common - Domain of unknown function DUF1832 Spea_2308 4 None None None 157963434 Common - magnesium transporter Spea_3622 171 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 157963686 Common - hypothetical protein Spea_3875 6 COG1213 COG1213, Predicted sugar nucleotidyltransferases Cell envelope biogenesis, outer membrane 157962455 Common - nuclease SbcCD, D subunit Spea_2634 133 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 157960801 Common - general secretion pathway protein B Spea_0973 8 None None None 157960256 Common - uroporphyrinogen decarboxylase Spea_0427 182 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 157959959 Common - Ferroxidase Spea_0129 85 COG1528 Ftn, Ferritin-like protein Inorganic ion transport and metabolism 157962330 Common - protein tyrosine phosphatase Spea_2509 128 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 157963432 Common - PTS IIA-like nitrogen-regulatory protein PtsN Spea_3618 135 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 157961403 Common - NADH:ubiquinone oxidoreductase, subunit E Spea_1577 76 COG2209 NqrE, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE Energy production and conversion 157963193 Common - cobalbumin biosynthesis protein Spea_3378 129 COG2087 CobU, Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase Coenzyme metabolism 157960470 Common - hypothetical protein Spea_0642 21 None None None 157960413 Common - CutA1 divalent ion tolerance protein Spea_0584 121 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 157960883 Common - hybrid cluster protein Spea_1055 75 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 157960987 Common - ABC transporter related Spea_1159 244 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 157962117 Nonpathogen - hypothetical protein Spea_2296 1 None None None 157961344 Common - SSS sodium solute transporter superfamily Spea_1518 138 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 157961076 Common - alkylphosphonate utilization operon protein PhnA Spea_1248 97 COG2824 PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism Inorganic ion transport and metabolism 157960803 Common - aspartate carbamoyltransferase Spea_0975 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 157961644 Common - Curli production assembly/transport component CsgG Spea_1820 15 COG1462 CsgG, Uncharacterized protein involved in formation of curli polymers Cell envelope biogenesis, outer membrane 157961221 Common - transcriptional acivator RfaH Spea_1394 69 COG0250 NusG, Transcription antiterminator Transcription 157961741 Common - ATP-binding protein, Mrp/Nbp35 family Spea_1918 232 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 157962583 Common - hypothetical protein Spea_2762 9 COG3184 COG3184, Uncharacterized protein conserved in bacteria Function unknown 157961956 Common - transcriptional regulator, LuxR family Spea_2135 35 COG2771 CsgD, DNA-binding HTH domain-containing proteins Transcription 157962669 Nonpathogen - hypothetical protein Spea_2850 3 None None None 157961881 Nonpathogen - hypothetical protein Spea_2060 2 None None None 157960205 Nonpathogen - hypothetical protein Spea_0376 1 None None None 157961120 Common - hypothetical protein Spea_1292 6 None None None 157961236 Common - glycosyl transferase group 1 Spea_1409 176 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 157962939 Common - protein of unknown function DUF819 Spea_3122 19 COG5505 COG5505, Predicted integral membrane protein Function unknown 157960229 Common - Ppx/GppA phosphatase Spea_0400 178 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 157962831 Common - hypothetical protein Spea_3013 21 COG3495 COG3495, Uncharacterized protein conserved in bacteria Function unknown 157960324 Common - hypothetical protein Spea_0495 3 None None None 157960698 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Spea_0870 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 157962814 Common - protein of unknown function DUF224 cysteine-rich region domain protein Spea_2996 146 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 157961020 Common - peptidase M23B Spea_1192 190 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 157961571 Common - phosphonate ABC transporter, periplasmic phosphonate-binding protein Spea_1747 62 COG3221 PhnD, ABC-type phosphate/phosphonate transport system, periplasmic component Inorganic ion transport and metabolism 157961965 Common - acyl-CoA dehydrogenase domain protein Spea_2144 128 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157960916 Common - type IV pilus assembly protein PilW Spea_1088 19 COG4966 PilW, Tfp pilus assembly protein PilW Cell motility and secretion / Intracellular trafficking and secretion 157962694 Common - UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase Spea_2875 175 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 157960913 Common - peptidylprolyl isomerase FKBP-type Spea_1085 123 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 157963444 Common - PGAP1 family protein Spea_3632 28 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 157963775 Common - hypothetical protein Spea_3964 5 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 157962858 Common - histidine kinase Spea_3040 215 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 157963578 Common - TPR repeat-containing protein Spea_3766 14 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 157960992 Common - 3,4-dihydroxy-2-butanone 4-phosphate synthase Spea_1164 230 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 157961770 Common - glutaredoxin 2 Spea_1947 6 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 157963781 Common - transcriptional regulator, LysR family Spea_3970 65 COG0583 LysR, Transcriptional regulator Transcription 157960451 Common - MauM/NapG family ferredoxin-type protein Spea_0622 57 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 157962122 Nonpathogen - hypothetical protein Spea_2301 2 None None None 157961373 Common - lipoprotein releasing system, transmembrane protein, LolC/E family Spea_1547 199 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 157962626 Common - hypothetical protein Spea_2806 6 None None None 157961510 Common - hypothetical protein Spea_1685 7 None None None 157962950 Common - GTP-binding protein YchF Spea_3133 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 157961562 Nonpathogen - hypothetical protein Spea_1738 1 None None None 157961496 Common - pyruvate formate-lyase activating enzyme Spea_1671 96 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 157963013 Common - alkylhydroperoxidase-like protein, AhpD family Spea_3196 76 COG2128 COG2128, Uncharacterized conserved protein Function unknown 157960162 Common - KAP P-loop domain protein Spea_0333 18 COG4928 COG4928, Predicted P-loop ATPase General function prediction only 157960268 Common - formate dehydrogenase, beta subunit Spea_0439 159 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 157963626 Common - UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase Spea_3815 212 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 157961483 Common - hypothetical protein Spea_1657 12 None None None 157960355 Common - aromatic amino acid transporter Spea_0526 38 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 157961334 Common - DNA polymerase III, subunits gamma and tau Spea_1508 248 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 157960589 Common - hypothetical protein Spea_0761 19 None None None 157962653 Nonpathogen - hypothetical protein Spea_2833 1 None None None 157960629 Common - efflux transporter, RND family, MFP subunit Spea_0801 95 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157961286 Common - DEAD/DEAH box helicase domain protein Spea_1460 237 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 157961015 Common - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Spea_1187 193 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 157960190 Common - diguanylate cyclase/phosphodiesterase with GAF sensor Spea_0361 180 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 157960794 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Spea_0966 110 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 157962498 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Spea_2677 169 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 157963127 Common - 5-formyltetrahydrofolate cyclo-ligase Spea_3311 182 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 157960347 Common - ribokinase Spea_0518 208 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 157961673 Common - hypothetical protein Spea_1849 17 None None None 157961971 Common - AMP-dependent synthetase and ligase Spea_2150 197 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 157961114 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Spea_1286 7 COG2243 CobF, Precorrin-2 methylase Coenzyme metabolism 157961517 Common - NAD-dependent epimerase/dehydratase Spea_1692 53 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 157962020 Common - hypothetical protein Spea_2199 22 COG4922 COG4922, Uncharacterized protein conserved in bacteria Function unknown 157963131 Common - pilin, putative Spea_3315 4 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 157961505 Common - O-methyltransferase, putative Spea_1680 16 None None None 157961252 Common - polysaccharide biosynthesis protein Spea_1426 79 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 157962311 Common - thioesterase superfamily protein Spea_2490 135 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 157962911 Common - bacterioferritin Spea_3094 105 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 157961797 Common - transcriptional regulator, LysR family Spea_1974 126 COG0583 LysR, Transcriptional regulator Transcription 157961849 Common - (NiFe) hydrogenase maturation protein HypF Spea_2028 113 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 157960407 Common - SSS sodium solute transporter superfamily Spea_0578 122 COG4146 COG4146, Predicted symporter General function prediction only 157962957 Common - CBS domain containing protein Spea_3140 219 COG4535 CorC, Putative Mg2+ and Co2+ transporter CorC Inorganic ion transport and metabolism 157961312 Common - serine O-acetyltransferase Spea_1486 189 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 157961012 Common - CTP synthase Spea_1184 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 157963146 Common - Biopolymer transport protein ExbD/TolR Spea_3330 3 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 157959952 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Spea_0122 58 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 157961975 Common - coenzyme A transferase Spea_2154 96 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 157962944 Common - glutamyl-tRNA reductase Spea_3127 182 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 157961646 Nonpathogen - hypothetical protein Spea_1822 1 None None None 157961822 Common - hypothetical protein Spea_2001 15 COG4313 COG4313, Protein involved in meta-pathway of phenol degradation Energy production and conversion 157962996 Common - hypothetical protein Spea_3179 6 None None None 157963747 Common - transcriptional regulator, LysR family Spea_3936 183 COG0583 LysR, Transcriptional regulator Transcription 157963514 Common - PAS/PAC sensor hybrid histidine kinase Spea_3702 226 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157960102 Common - hypothetical protein Spea_0273 33 None None None 157963650 Common - deoxyuridine 5'-triphosphate nucleotidohydrolase Dut Spea_3839 180 COG0756 Dut, dUTPase Nucleotide transport and metabolism 157960980 Common - iron-containing alcohol dehydrogenase Spea_1152 174 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 157960220 Common - ribosomal protein L11 methyltransferase Spea_0391 186 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 157962203 Common - phosphomethylpyrimidine kinase Spea_2382 223 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 157960728 Common - methyl-accepting chemotaxis sensory transducer Spea_0900 140 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157960909 Common - integral membrane protein MviN Spea_1081 198 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 157961006 Common - transcriptional regulator, LysR family Spea_1178 165 COG0583 LysR, Transcriptional regulator Transcription 157961001 Common - putative glutathione S-transferase Spea_1173 79 COG0435 ECM4, Predicted glutathione S-transferase Posttranslational modification, protein turnover, chaperones 157960576 Common - diguanylate cyclase Spea_0748 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 157963320 Common - protein of unknown function UPF0270 Spea_3506 1 COG3089 COG3089, Uncharacterized protein conserved in bacteria Function unknown 157962604 Common - acetyl-CoA acetyltransferase Spea_2783 185 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 157961492 Common - hypothetical protein Spea_1667 3 None None None 157963388 Common - flavocytochrome c Spea_3574 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 157960294 Common - NUDIX hydrolase Spea_0465 29 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 157960815 Common - hypothetical protein Spea_0987 14 None None None 157963144 Common - TonB family protein Spea_3328 67 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 157960900 Common - hypothetical protein Spea_1072 1 None None None 157960843 Common - Hpt protein Spea_1015 22 COG2198 ArcB, FOG: HPt domain Signal transduction mechanisms 157961127 Common - GCN5-related N-acetyltransferase Spea_1299 27 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 157959870 Common - shikimate 5-dehydrogenase Spea_0040 223 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 157960097 Common - transcriptional regulator, TraR/DksA family Spea_0268 23 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 157961521 Common - Na+/solute symporter Spea_1696 166 COG4147 DhlC, Predicted symporter General function prediction only 157960854 Common - hypothetical protein Spea_1026 2 None None None 157963597 Common - major facilitator superfamily MFS_1 Spea_3785 18 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 157961132 Common - hypothetical protein Spea_1304 87 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 157963049 Common - beta-lactamase domain protein Spea_3232 127 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 157963110 Nonpathogen - hypothetical protein Spea_3294 3 None None None 157963836 Common - transcriptional regulator, TetR family Spea_4025 4 COG1309 AcrR, Transcriptional regulator Transcription 157961650 Common - thioesterase superfamily protein Spea_1826 31 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 157963339 Common - hypothetical protein Spea_3525 18 None None None 157962148 Common - transcriptional regulator, MarR family Spea_2327 117 COG1846 MarR, Transcriptional regulators Transcription 157960746 Common - hypothetical protein Spea_0918 8 None None None 157962932 Common - VanZ family protein Spea_3115 10 COG5652 COG5652, Predicted integral membrane protein Function unknown 157962652 Common - hypothetical protein Spea_2832 3 None None None 157960931 Common - hypothetical protein Spea_1103 18 COG4299 COG4299, Uncharacterized protein conserved in bacteria Function unknown 157962501 Common - ATP-dependent Clp protease, ATP-binding subunit ClpX Spea_2680 235 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 157961441 Common - transposase Spea_1615 9 None None None 157963288 Nonpathogen - hypothetical protein Spea_3474 1 None None None 157961181 Common - flagellar protein FlaG protein Spea_1353 25 COG1334 FlaG, Uncharacterized flagellar protein FlaG Cell motility and secretion 157963279 Common - integrase family protein Spea_3465 16 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 157963794 Common - NapC/NirT cytochrome c domain protein Spea_3983 48 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 157960719 Common - major facilitator superfamily MFS_1 Spea_0891 61 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 157960838 Common - Inosine/uridine-preferring nucleoside hydrolase Spea_1010 88 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 157960380 Common - dTDP-4-dehydrorhamnose reductase Spea_0551 168 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 157962668 Nonpathogen - hypothetical protein Spea_2849 3 None None None 157961125 Common - NrfJ-related protein Spea_1297 9 None None None 157963504 Common - pentapeptide repeat protein Spea_3692 48 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 157960491 Common - sulfate adenylyltransferase, small subunit Spea_0663 136 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 157961609 Common - Succinate dehydrogenase hydrophobic membrane anchor Spea_1785 51 COG2142 SdhD, Succinate dehydrogenase, hydrophobic anchor subunit Energy production and conversion 157964031 Common - protein of unknown function DUF610 YibQ Spea_4220 62 COG2861 COG2861, Uncharacterized protein conserved in bacteria Function unknown 157963224 Common - hypothetical protein Spea_3410 9 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 157961139 Nonpathogen - hypothetical protein Spea_1311 1 None None None 157961585 Common - diguanylate cyclase Spea_1761 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157960593 Common - protein of unknown function DUF1696 Spea_0765 29 None None None 157962419 Common - fatty acid oxidation complex, alpha subunit FadJ Spea_2598 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 157962481 Common - histone deacetylase superfamily Spea_2660 156 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 157963923 Common - hypothetical protein Spea_4112 18 COG3111 COG3111, Uncharacterized conserved protein Function unknown 157960052 Common - competence/damage-inducible protein CinA Spea_0223 213 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 157963391 Common - two component transcriptional regulator, winged helix family Spea_3577 219 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157963254 Common - hypothetical protein Spea_3440 1 None None None 157963474 Common - Xanthine/uracil/vitamin C permease Spea_3662 134 COG2252 COG2252, Permeases General function prediction only 157962613 Common - short-chain dehydrogenase/reductase SDR Spea_2792 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157963840 Common - Disulphide bond formation protein DsbB Spea_4029 28 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 157963959 Common - Chorismate lyase Spea_4148 47 COG3161 UbiC, 4-hydroxybenzoate synthetase (chorismate lyase) Coenzyme metabolism 157961712 Nonpathogen - hypothetical protein Spea_1888 2 None None None 157963379 Common - hypothetical protein Spea_3565 21 COG5345 COG5345, Uncharacterized protein conserved in bacteria Function unknown 157961434 Common - transcriptional regulator, LysR family Spea_1608 140 COG0583 LysR, Transcriptional regulator Transcription 157963166 Common - hypothetical protein Spea_3350 9 COG4519 COG4519, Uncharacterized protein conserved in bacteria Function unknown 157961900 Common - hypothetical protein Spea_2079 27 COG3122 COG3122, Uncharacterized protein conserved in bacteria Function unknown 157963345 Common - TonB-dependent receptor plug Spea_3531 129 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 157962843 Common - metallophosphoesterase Spea_3025 64 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 157960272 Common - selenocysteine-specific translation elongation factor Spea_0443 249 COG3276 SelB, Selenocysteine-specific translation elongation factor Translation, ribosomal structure and biogenesis 157963115 Common - protein of unknown function DUF1568 Spea_3299 24 None None None 157960512 Common - cob(II)yrinic acid a,c-diamide reductase Spea_0684 67 COG0778 NfnB, Nitroreductase Energy production and conversion 157963453 Common - ABC transporter related Spea_3641 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 157963543 Common - histone family protein DNA-binding protein Spea_3731 211 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 157964056 Common - ATP synthase F0, C subunit Spea_4245 119 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 157960565 Common - transcriptional regulator, AsnC family Spea_0737 156 COG1522 Lrp, Transcriptional regulators Transcription 157960977 Common - hypothetical protein Spea_1149 1 None None None 157961304 Common - carbon starvation protein CstA Spea_1478 109 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 157961628 Common - dethiobiotin synthase Spea_1804 157 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 157960118 Nonpathogen - hypothetical protein Spea_0289 1 None None None 157960959 Common - Holliday junction resolvase YqgF Spea_1131 183 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 157963938 Common - formate dehydrogenase, gamma subunit Spea_4127 66 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 157962192 Common - gonadoliberin III-related protein Spea_2371 18 None None None 157963401 Common - protein of unknown function DUF481 Spea_3587 34 COG3137 COG3137, Putative salt-induced outer membrane protein Cell envelope biogenesis, outer membrane 157962049 Common - Aspartate transaminase Spea_2228 74 COG1448 TyrB, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 157963093 Common - CMP/dCMP deaminase zinc-binding Spea_3277 78 COG2131 ComEB, Deoxycytidylate deaminase Nucleotide transport and metabolism 157963934 Common - MOSC domain containing protein Spea_4123 77 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 157960138 Common - hypothetical protein Spea_0309 4 None None None 157962434 Common - Rhodanese domain protein Spea_2613 132 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 157962459 Common - protein of unknown function DUF81 Spea_2638 130 COG0730 COG0730, Predicted permeases General function prediction only 157963129 Common - hypothetical protein Spea_3313 17 COG5486 COG5486, Predicted metal-binding integral membrane protein Function unknown 157961395 Common - UspA domain protein Spea_1569 75 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 157961032 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Spea_1204 200 COG0388 COG0388, Predicted amidohydrolase General function prediction only 157962901 Common - transposase Spea_3083 9 None None None 157963103 Common - NADH dehydrogenase (quinone) Spea_3287 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 157961661 Common - ABC transporter related Spea_1837 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 157962908 Common - aminoacyl-histidine dipeptidase Spea_3091 59 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 157963486 Common - BCCT transporter Spea_3674 96 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 157959925 Common - protein of unknown function DUF885 Spea_0095 44 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 157963004 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Spea_3187 162 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 157962363 Common - hypothetical protein Spea_2542 3 None None None 157962774 Common - hypothetical protein Spea_2956 3 COG2852 COG2852, Uncharacterized protein conserved in bacteria Function unknown 157959850 Common - protein of unknown function UPF0029 Spea_0020 133 COG1739 COG1739, Uncharacterized conserved protein Function unknown 157960285 Common - OmpA domain protein transmembrane region-containing protein Spea_0456 102 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 157961688 Common - gamma-glutamyltransferase Spea_1864 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 157961842 Common - type II secretion system protein Spea_2021 82 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion 157960131 Common - response regulator receiver modulated serine phosphatase Spea_0302 219 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 157962079 Common - thioredoxin reductase Spea_2258 248 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 157961857 Common - NUDIX hydrolase Spea_2036 130 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 157961079 Common - protein of unknown function DUF417 Spea_1251 27 COG3059 COG3059, Predicted membrane protein Function unknown 157960197 Common - Cadherin Spea_0368 168 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 157963760 Common - type IV pilus assembly PilZ Spea_3949 4 None None None 157960558 Nonpathogen - hypothetical protein Spea_0730 2 None None None 157960667 Common - ABC transporter related Spea_0839 249 COG5265 ATM1, ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components Posttranslational modification, protein turnover, chaperones 157960609 Common - hypothetical protein Spea_0781 13 None None None 157963587 Common - nuclease (SNase domain protein) Spea_3775 32 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 157960063 Common - Fimbrial assembly family protein Spea_0234 43 COG3166 PilN, Tfp pilus assembly protein PilN Cell motility and secretion / Intracellular trafficking and secretion 157963933 Common - hypothetical protein Spea_4122 15 COG3296 COG3296, Uncharacterized protein conserved in bacteria Function unknown 157963804 Common - putative permease of the major facilitator superfamily Spea_3993 3 None None None 157964044 Common - guanosine monophosphate reductase Spea_4233 233 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 157963419 Common - SpoIIAA family protein Spea_3605 4 COG3113 COG3113, Predicted NTP binding protein (contains STAS domain) General function prediction only 157961489 Common - dihydroneopterin aldolase Spea_1664 40 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 157962552 Common - MscS Mechanosensitive ion channel Spea_2731 18 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 157960464 Common - purine nucleoside phosphorylase Spea_0635 97 COG0813 DeoD, Purine-nucleoside phosphorylase Nucleotide transport and metabolism 157961355 Common - Ferrochelatase Spea_1529 170 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 157961978 Common - 2-nitropropane dioxygenase NPD Spea_2157 99 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 157961235 Common - polysaccharide biosynthesis protein Spea_1408 75 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 157963863 Common - transcriptional regulator, LysR family Spea_4052 164 COG0583 LysR, Transcriptional regulator Transcription 157963561 Common - hypothetical protein Spea_3749 55 COG3164 COG3164, Predicted membrane protein Function unknown 157963636 Common - 3-isopropylmalate dehydratase, small subunit Spea_3825 210 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 157962108 Common - transcriptional regulator, LacI family Spea_2287 130 COG1609 PurR, Transcriptional regulators Transcription 157961055 Common - NnrS family protein Spea_1227 56 COG3213 NnrS, Uncharacterized protein involved in response to NO Inorganic ion transport and metabolism 157963336 Common - Biopolymer transport protein ExbD/TolR Spea_3522 135 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 157962739 Nonpathogen - Radical SAM domain protein Spea_2921 7 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 157960873 Common - protein of unknown function DUF962 Spea_1045 26 COG4539 COG4539, Predicted membrane protein Function unknown 157962518 Common - decaheme cytochrome c Spea_2697 8 None None None 157962385 Common - Tol-Pal system beta propeller repeat TolB Spea_2564 158 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 157960261 Common - phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Spea_0432 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 157961366 Common - protein of unknown function UPF0227 Spea_1540 21 COG3150 COG3150, Predicted esterase General function prediction only 157961579 Common - histidine kinase Spea_1755 216 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157961680 Common - putative transcriptional regulator, Fis family protein Spea_1856 8 None None None 157963050 Common - hypothetical protein Spea_3233 16 None None None 157960240 Common - Prepilin peptidase Spea_0411 123 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 157960433 Common - transcriptional regulator, LysR family Spea_0604 184 COG0583 LysR, Transcriptional regulator Transcription 157963206 Common - hypothetical protein Spea_3391 12 COG2841 COG2841, Uncharacterized protein conserved in bacteria Function unknown 157963152 Common - protein of unknown function DUF218 Spea_3336 8 COG1434 COG1434, Uncharacterized conserved protein Function unknown 157963554 Common - Ig domain protein group 1 domain protein Spea_3742 16 None None None 157959878 Common - UDP-N-acetylglucosamine 2-epimerase Spea_0048 81 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 157962757 Common - protein of unknown function DUF599 Spea_2939 27 COG3821 COG3821, Predicted membrane protein Function unknown 157960519 Common - hypothetical protein Spea_0691 1 None None None 157961696 Common - hypothetical protein Spea_1872 20 COG3593 COG3593, Predicted ATP-dependent endonuclease of the OLD family DNA replication, recombination, and repair 157962880 Common - protein of unknown function DUF150 Spea_3062 178 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 157961604 Common - acriflavin resistance protein Spea_1780 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 157961146 Common - cytochrome bd ubiquinol oxidase subunit I Spea_1318 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 157962352 Common - translation initiation factor IF-1 Spea_2531 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 157963894 Common - metal dependent phosphohydrolase Spea_4083 123 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 157963986 Common - ABC transporter related Spea_4175 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 157963867 Common - LemA family protein Spea_4056 130 COG1704 LemA, Uncharacterized conserved protein Function unknown 157962064 Common - quinolinate synthetase complex, A subunit Spea_2243 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 157960420 Common - UBA/THIF-type NAD/FAD binding protein Spea_0591 151 COG1179 COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Coenzyme metabolism 157963044 Common - ferredoxin-dependent glutamate synthase Spea_3227 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 157960675 Common - Dyp-type peroxidase family Spea_0847 58 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 157963695 Common - ATP-dependent DNA helicase RecG Spea_3884 222 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 157960824 Common - hypothetical protein Spea_0996 1 None None None 157961302 Common - siroheme synthase Spea_1476 149 COG1648 CysG, Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) Coenzyme metabolism 157962158 Common - pyruvate kinase Spea_2337 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 157963325 Common - two component transcriptional regulator, winged helix family Spea_3511 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157963955 Common - DNA binding domain, excisionase family Spea_4144 49 COG1910 COG1910, Periplasmic molybdate-binding protein/domain Inorganic ion transport and metabolism 157962375 Common - two component transcriptional regulator, LuxR family Spea_2554 196 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 157960891 Common - Trp operon repressor Spea_1063 21 COG2973 TrpR, Trp operon repressor Transcription 157961917 Common - protein of unknown function DUF227 Spea_2096 6 None None None 157960313 Common - Polysulphide reductase NrfD Spea_0484 33 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 157963621 Common - UDP-N-acetylmuramate--alanine ligase Spea_3810 208 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 157960208 Common - protein of unknown function DUF484 Spea_0379 53 COG3159 COG3159, Uncharacterized protein conserved in bacteria Function unknown 157961768 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Spea_1945 196 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 157961056 Common - Nitrite reductase (cytochrome; ammonia-forming) Spea_1228 40 COG3303 NrfA, Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit Inorganic ion transport and metabolism 157962214 Common - Protein of unknown function DUF1974 Spea_2393 147 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157962783 Common - Peptidase M1 membrane alanine aminopeptidase Spea_2965 143 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 157963553 Common - protein of unknown function DUF615 Spea_3741 59 COG3028 COG3028, Uncharacterized protein conserved in bacteria Function unknown 157963989 Common - Lytic transglycosylase catalytic Spea_4178 105 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 157960889 Common - cytochrome B561 Spea_1061 45 COG3658 COG3658, Cytochrome b Energy production and conversion 157961862 Common - isocitrate lyase and phosphorylmutase Spea_2041 113 COG2224 AceA, Isocitrate lyase Energy production and conversion 157963505 Common - hypothetical protein Spea_3693 8 None None None 157962857 Common - molybdopterin oxidoreductase Spea_3039 184 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 157961477 Common - Peptidase S49 domain protein Spea_1651 189 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 157961819 Common - hypothetical protein Spea_1998 10 None None None 157963879 Common - glutathione-disulfide reductase Spea_4068 244 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 157960207 Common - Diaminopimelate epimerase Spea_0378 202 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 157961211 Common - hypothetical protein Spea_1383 1 None None None 157961961 Common - MaoC domain protein dehydratase Spea_2140 12 None None None 157960942 Common - transposase IS116/IS110/IS902 family protein Spea_1114 98 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 157960967 Common - OmpA/MotB domain protein Spea_1139 146 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 157962269 Common - AMP-dependent synthetase and ligase Spea_2448 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 157962663 Common - transcriptional regulator, LysR family Spea_2844 179 COG0583 LysR, Transcriptional regulator Transcription 157960537 Nonpathogen - PepSY-associated TM helix domain protein Spea_0709 5 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 157962293 Common - putative PAS/PAC sensor protein Spea_2472 83 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 157962081 Common - ribosomal protein L20 Spea_2260 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 157962323 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Spea_2502 170 COG0546 Gph, Predicted phosphatases General function prediction only 157963272 Common - hypothetical protein Spea_3458 7 None None None 157960410 Nonpathogen - WD40 domain protein beta Propeller Spea_0581 6 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 157962039 Common - hypothetical protein Spea_2218 23 COG3198 COG3198, Uncharacterized protein conserved in bacteria Function unknown 157960583 Common - Ion transport 2 domain protein Spea_0755 29 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 157963592 Common - Sporulation domain protein Spea_3780 30 COG3087 FtsN, Cell division protein Cell division and chromosome partitioning 157960215 Common - hypothetical protein Spea_0386 82 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157963905 Common - extracellular solute-binding protein, family 1 Spea_4094 62 COG2998 TupB, ABC-type tungstate transport system, permease component Coenzyme metabolism 157961645 Nonpathogen - hypothetical protein Spea_1821 1 None None None 157960577 Common - hypothetical protein Spea_0749 1 None None None 157962092 Common - major facilitator superfamily MFS_1 Spea_2271 42 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 157960737 Common - Hpt sensor hybrid histidine kinase Spea_0909 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157960924 Common - transcriptional regulator, LacI family Spea_1096 129 COG1609 PurR, Transcriptional regulators Transcription 157962744 Common - DEAD/DEAH box helicase domain protein Spea_2926 241 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 157963235 Common - secretion protein HlyD family protein Spea_3421 97 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 157961979 Common - Enoyl-CoA hydratase/isomerase Spea_2158 150 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 157962307 Common - rRNA (guanine-N(1)-)-methyltransferase Spea_2486 90 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 157962156 Common - glucose-6-phosphate 1-dehydrogenase Spea_2335 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 157960896 Common - threonine synthase Spea_1068 188 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 157962169 Common - Radical SAM domain protein Spea_2348 165 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 157960908 Common - ribosomal protein S20 Spea_1080 144 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 157962574 Common - hypothetical protein Spea_2753 3 None None None 157964046 Common - transcriptional regulator, DeoR family Spea_4235 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 157961556 Common - Radical SAM domain protein Spea_1732 83 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 157963712 Common - Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ Spea_3901 23 COG4706 COG4706, Predicted 3-hydroxylacyl-(acyl carrier protein) dehydratase Lipid metabolism 157963637 Common - 3-isopropylmalate dehydratase, large subunit Spea_3826 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 157961899 Common - short-chain dehydrogenase/reductase SDR Spea_2078 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157963947 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Spea_4136 178 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 157961413 Common - Indole-3-glycerol-phosphate synthase., Phosphoribosylanthranilate isomerase Spea_1587 220 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 157962031 Nonpathogen - hypothetical protein Spea_2210 1 None None None 157963163 Common - two component transcriptional regulator, winged helix family Spea_3347 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157963618 Common - cell division protein FtsZ Spea_3807 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 157960250 Common - dihydrolipoamide dehydrogenase Spea_0421 244 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 157963194 Common - cobalamin 5'-phosphate synthase Spea_3379 73 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 157961596 Common - protein of unknown function DUF343 Spea_1772 100 COG2835 COG2835, Uncharacterized conserved protein Function unknown 157964004 Common - hypothetical protein Spea_4193 1 None None None 157959915 Common - sigma54 specific transcriptional regulator, Fis family Spea_0085 169 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 157962386 Common - Tol-Pal system TolA Spea_2565 16 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 157959957 Common - molybdopterin synthase sulfurylase MoeB Spea_0127 220 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 157962299 Common - putative agmatinase Spea_2478 153 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 157961942 Common - Rieske (2Fe-2S) domain protein Spea_2121 60 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 157963691 Common - putative endoribonuclease L-PSP Spea_3880 187 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 157961648 Common - histidine triad (HIT) protein Spea_1824 227 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 157960497 Common - major facilitator superfamily MFS_1 Spea_0669 17 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 157963026 Common - TonB family protein Spea_3209 52 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 157961280 Common - major facilitator superfamily MFS_1 Spea_1454 136 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 157961473 Common - segregation and condensation protein B Spea_1647 152 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 157959902 Common - flagellar basal body FlaE domain protein Spea_0072 126 COG1749 FlgE, Flagellar hook protein FlgE Cell motility and secretion 157962507 Common - UDP-2,3-diacylglucosamine hydrolase Spea_2686 79 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 157960508 Common - porin Gram-negative type Spea_0680 23 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 157964066 Common - MshA, mannose-sensitive haemaglutinin Spea_4255 5 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 157961073 Common - nitroreductase Spea_1245 86 COG0778 NfnB, Nitroreductase Energy production and conversion 157963122 Common - yecA family protein Spea_3306 41 COG3079 COG3079, Uncharacterized protein conserved in bacteria Function unknown 157960482 Common - sulfite reductase (NADPH) hemoprotein, beta-component Spea_0654 146 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 157962241 Common - exodeoxyribonuclease V, beta subunit Spea_2420 213 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 157962536 Common - Pyridoxal-dependent decarboxylase Spea_2715 115 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 157961755 Common - YebG family protein Spea_1932 20 COG3141 COG3141, Uncharacterized protein conserved in bacteria Function unknown 157961085 Common - YagBYeeUYfjZ family protein Spea_1257 10 None None None 157963261 Common - StbA family protein Spea_3447 13 None None None 157963296 Common - phage shock protein A, PspA Spea_3482 40 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 157959897 Common - hypothetical protein Spea_0067 19 COG3951 COG3951, Rod binding protein Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 157962869 Common - TatD-related deoxyribonuclease Spea_3051 235 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 157962919 Common - NADH:ubiquinone oxidoreductase, subunit B Spea_3102 76 COG1805 NqrB, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB Energy production and conversion 157961582 Common - NAD+ synthetase Spea_1758 162 COG0171 NadE, NAD synthase Coenzyme metabolism 157962132 Common - hypothetical protein Spea_2311 29 None None None 157962247 Common - Nitrate reductase cytochrome c-type subunit (NapB) Spea_2426 37 COG3043 NapB, Nitrate reductase cytochrome c-type subunit Energy production and conversion 157962878 Common - translation initiation factor IF-2 Spea_3060 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 157962693 Common - beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ Spea_2874 188 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 157963338 Common - MotA/TolQ/ExbB proton channel Spea_3524 19 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 157959866 Common - DNA topoisomerase type IA zn finger domain protein Spea_0036 142 COG0551 TopA, Zn-finger domain associated with topoisomerase type I DNA replication, recombination, and repair 157961887 Common - ubiquinone biosynthesis O-methyltransferase Spea_2066 159 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 157961743 Common - deoxycytidine triphosphate deaminase Spea_1920 26 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 157962802 Common - transcriptional regulator, LysR family Spea_2984 185 COG0583 LysR, Transcriptional regulator Transcription 157961660 Common - hypothetical protein Spea_1836 1 None None None 157963496 Common - hypothetical protein Spea_3684 2 None None None 157963314 Common - hypothetical protein Spea_3500 21 COG3529 COG3529, Predicted nucleic-acid-binding protein containing a Zn-ribbon domain General function prediction only 157960476 Common - transcriptional regulator, TetR family Spea_0648 4 COG1309 AcrR, Transcriptional regulator Transcription 157961932 Common - protein of unknown function UPF0005 Spea_2111 118 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 157963886 Common - protein of unknown function DUF6 transmembrane Spea_4075 81 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 157961818 Common - methyl-accepting chemotaxis sensory transducer Spea_1997 151 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157961617 Common - Auxin Efflux Carrier Spea_1793 117 COG0679 COG0679, Predicted permeases General function prediction only 157962048 Common - protein of unknown function UPF0052 and CofD Spea_2227 88 COG0391 COG0391, Uncharacterized conserved protein Function unknown 157963157 Common - periplasmic nitrate reductase NapE Spea_3341 2 COG4459 NapE, Periplasmic nitrate reductase system, NapE component Energy production and conversion 157962354 Common - ATP-dependent Clp protease adaptor protein ClpS Spea_2533 119 COG2127 COG2127, Uncharacterized conserved protein Function unknown 157962777 Common - hypothetical protein Spea_2959 37 COG5587 COG5587, Uncharacterized conserved protein Function unknown 157962175 Common - electron transport complex, RnfABCDGE type, B subunit Spea_2354 127 COG2878 COG2878, Predicted NADH:ubiquinone oxidoreductase, subunit RnfB Energy production and conversion 157963544 Common - hypothetical protein Spea_3732 39 None None None 157963182 Common - response regulator receiver protein Spea_3367 169 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 157962400 Common - protein of unknown function DUF1214 Spea_2579 38 COG5361 COG5361, Uncharacterized conserved protein Function unknown 157963737 Common - ThiJ/PfpI domain protein Spea_3926 107 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 157963075 Common - transposase Spea_3258 9 None None None 157964054 Common - ATP synthase F1, delta subunit Spea_4243 164 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 157962071 Nonpathogen - hypothetical protein Spea_2250 1 None None None 157963572 Common - methylation site containing protein Spea_3760 7 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 157960718 Common - GPR1/FUN34/yaaH family protein Spea_0890 51 COG1584 COG1584, Predicted membrane protein Function unknown 157960611 Nonpathogen - hypothetical protein Spea_0783 1 None None None 157962262 Common - protein of unknown function UPF0153 Spea_2441 74 COG2983 COG2983, Uncharacterized conserved protein Function unknown 157963729 Nonpathogen - hypothetical protein Spea_3918 2 None None None 157961065 Common - conserved hypothetical cytosolic protein Spea_1237 16 None None None 157961457 Common - galactose-1-phosphate uridylyltransferase Spea_1631 79 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 157961376 Common - hypothetical protein Spea_1550 3 None None None 157964070 Common - ribonuclease P protein component Spea_4259 73 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 157960993 Common - 6,7-dimethyl-8-ribityllumazine synthase Spea_1165 229 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 157962891 Common - transcription elongation factor GreA Spea_3073 204 COG0782 GreA, Transcription elongation factor Transcription 157961218 Common - VacJ family lipoprotein Spea_1390 94 COG2853 VacJ, Surface lipoprotein Cell envelope biogenesis, outer membrane 157963821 Common - HesB/YadR/YfhF-family protein Spea_4010 75 COG0694 COG0694, Thioredoxin-like proteins and domains Posttranslational modification, protein turnover, chaperones 157962676 Common - amidohydrolase Spea_2857 41 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 157963032 Common - dihydroorotase, homodimeric type Spea_3215 93 COG0418 PyrC, Dihydroorotase Nucleotide transport and metabolism 157960965 Common - transmembrane pair domain protein Spea_1137 37 COG4125 COG4125, Predicted membrane protein Function unknown 157959907 Common - hypothetical protein Spea_0077 2 None None None 157960331 Common - Glutathione S-transferase domain Spea_0502 52 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 157961342 Common - putative hydrolase Spea_1516 35 COG0657 Aes, Esterase/lipase Lipid metabolism 157960015 Common - ribosomal protein L4/L1e Spea_0185 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 157961349 Common - N-acetylglucosamine-6-phosphate deacetylase Spea_1523 118 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 157960501 Common - Protoporphyrinogen oxidase Spea_0673 34 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 157963014 Common - transcriptional regulator, LysR family Spea_3197 178 COG0583 LysR, Transcriptional regulator Transcription 157961358 Common - sodium:dicarboxylate symporter Spea_1532 164 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 157962452 Common - putative transposase Spea_2631 28 None None None 157962862 Common - membrane protein Spea_3044 1 COG3726 AhpA, Uncharacterized membrane protein affecting hemolysin expression General function prediction only 157963681 Common - hypothetical protein Spea_3870 4 None None None 157960153 Common - tetraheme cytochrome c, putative Spea_0324 4 None None None 157960615 Common - Methionine adenosyltransferase Spea_0787 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 157963449 Nonpathogen - hypothetical protein Spea_3637 1 None None None 157962433 Common - hypothetical protein Spea_2612 39 None None None 157962339 Common - two component transcriptional regulator, winged helix family Spea_2518 214 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157961867 Common - putative deoxyguanosinetriphosphate triphosphohydrolase Spea_2046 159 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 157960127 Common - Cellulose synthase (UDP-forming) Spea_0298 71 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 157960692 Common - SurA domain Spea_0864 158 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 157960104 Common - hypothetical protein Spea_0275 2 None None None 157962730 Common - diguanylate cyclase Spea_2912 180 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157963521 Common - Enoyl-CoA hydratase/isomerase Spea_3709 159 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 157962690 Common - Ribonuclease H Spea_2871 212 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 157960765 Common - aldehyde dehydrogenase Spea_0937 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 157961446 Common - Colicin V production protein Spea_1620 106 COG1286 CvpA, Uncharacterized membrane protein, required for colicin V production General function prediction only 157960076 Common - transcriptional regulator, LysR family Spea_0247 190 COG0583 LysR, Transcriptional regulator Transcription 157961916 Common - hypothetical protein Spea_2095 1 None None None 157963854 Common - General substrate transporter Spea_4043 182 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 157960391 Common - 5,10-methylenetetrahydrofolate reductase Spea_0562 144 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 157961603 Common - acriflavin resistance protein Spea_1779 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 157963851 Common - Electron transfer flavoprotein alpha subunit Spea_4040 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 157962975 Common - hypothetical protein Spea_3158 1 None None None 157961170 Common - flagellar hook capping protein Spea_1342 82 COG1843 FlgD, Flagellar hook capping protein Cell motility and secretion 157961725 Common - hypothetical protein Spea_1902 5 None None None 157961595 Common - tetraacyldisaccharide 4'-kinase Spea_1771 130 COG1663 LpxK, Tetraacyldisaccharide-1-P 4'-kinase Cell envelope biogenesis, outer membrane 157961555 Common - hypothetical protein Spea_1731 2 None None None 157961871 Common - hypothetical protein Spea_2050 23 COG4394 COG4394, Uncharacterized protein conserved in bacteria Function unknown 157960699 Common - phosphoribosylglycinamide formyltransferase 2 Spea_0871 215 COG0027 PurT, Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) Nucleotide transport and metabolism 157961380 Common - regulatory protein MarR Spea_1554 10 None None None 157961546 Common - magnesium and cobalt transport protein CorA Spea_1722 159 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 157960386 Common - putative plasmid transfer protein Spea_0557 10 None None None 157960036 Common - ribosomal protein S11 Spea_0207 248 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 157961980 Common - acyl-CoA dehydrogenase domain protein Spea_2159 143 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157961836 Common - hypothetical protein Spea_2015 4 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 157959994 Common - tRNA (uracil-5-)-methyltransferase Spea_0164 164 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 157960689 Common - ApaG domain protein Spea_0861 89 COG2967 ApaG, Uncharacterized protein affecting Mg2+/Co2+ transport Inorganic ion transport and metabolism 157962823 Common - DEAD/DEAH box helicase domain protein Spea_3005 234 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 157962719 Common - hypothetical protein Spea_2900 12 COG5595 COG5595, Zn-ribbon-containing, possibly nucleic-acid-binding protein General function prediction only 157960419 Common - porin Gram-negative type Spea_0590 31 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 157961701 Common - Cytochrome-c peroxidase Spea_1877 94 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 157960744 Common - Carboxypeptidase Taq Spea_0916 82 COG2317 COG2317, Zn-dependent carboxypeptidase Amino acid transport and metabolism 157960707 Common - hypothetical protein Spea_0879 3 None None None 157963332 Common - peptidase S9 prolyl oligopeptidase active site domain protein Spea_3518 99 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 157961963 Common - acyl-CoA dehydrogenase domain protein Spea_2142 159 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157961145 Common - phosphoribosylformylglycinamidine synthase Spea_1317 233 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 157960300 Common - putative esterase Spea_0471 53 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 157962449 Common - protein of unknown function DUF1568 Spea_2628 18 None None None 157961228 Common - GCN5-related N-acetyltransferase Spea_1401 6 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 157962404 Common - asparagine synthase (glutamine-hydrolyzing) Spea_2583 163 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 157961247 Common - CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase Spea_1421 31 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 157961436 Common - Ornithine cyclodeaminase Spea_1610 86 COG2423 COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog Amino acid transport and metabolism 157961566 Nonpathogen - hypothetical protein Spea_1742 1 None None None 157964014 Common - hypothetical protein Spea_4203 88 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 157962379 Common - acetate--CoA ligase Spea_2558 212 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 157962010 Common - hypothetical protein Spea_2189 8 None None None 157960371 Common - hypothetical protein Spea_0542 1 None None None 157959949 Common - hypothetical protein Spea_0119 21 COG5572 COG5572, Predicted integral membrane protein Function unknown 157960233 Common - TonB-dependent receptor Spea_0404 109 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 157963529 Common - hypothetical protein Spea_3717 1 None None None 157962994 Common - Endothelin-converting enzyme 1 Spea_3177 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 157960003 Common - ribosomal protein L11 Spea_0173 247 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 157959889 Common - flagellar hook-length control protein Spea_0059 23 COG3144 FliK, Flagellar hook-length control protein Cell motility and secretion 157959935 Common - Rhodanese domain protein Spea_0105 121 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 157961892 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Spea_2071 228 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 157959929 Common - hypothetical protein Spea_0099 19 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 157961166 Common - response regulator receiver modulated CheW protein Spea_1338 191 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 157961720 Common - integrase family protein Spea_1897 8 None None None 157963722 Common - hypothetical protein Spea_3911 14 None None None 157962577 Common - protein of unknown function DUF1415 Spea_2756 30 COG3310 COG3310, Uncharacterized protein conserved in bacteria Function unknown 157963870 Common - phosphodiesterase, MJ0936 family Spea_4059 45 COG0622 COG0622, Predicted phosphoesterase General function prediction only 157961519 Common - protein serine/threonine phosphatase Spea_1694 63 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 157961960 Common - acyl-CoA dehydrogenase domain protein Spea_2139 120 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157961736 Nonpathogen - hypothetical protein Spea_1913 2 None None None 157960786 Common - RNA polymerase, sigma 70 subunit, RpoD Spea_0958 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 157960367 Common - hypothetical protein Spea_0538 1 None None None 157963257 Common - hypothetical protein Spea_3443 5 None None None 157960548 Common - two component, sigma54 specific, transcriptional regulator, Fis family Spea_0720 196 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 157962396 Common - Na+/H+ antiporter NhaC Spea_2575 29 COG2056 COG2056, Predicted permease General function prediction only 157962007 Common - beta-lactamase domain protein Spea_2186 54 COG1237 COG1237, Metal-dependent hydrolases of the beta-lactamase superfamily II General function prediction only 157962238 Common - protein of unknown function DUF58 Spea_2417 39 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 157961732 Common - heat shock protein Hsp20 Spea_1909 67 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 157960064 Common - Pilus assembly protein PilO Spea_0235 48 COG3167 PilO, Tfp pilus assembly protein PilO Cell motility and secretion / Intracellular trafficking and secretion 157960087 Common - transcriptional regulator, LysR family Spea_0258 21 COG0583 LysR, Transcriptional regulator Transcription 157962715 Common - GCN5-related N-acetyltransferase Spea_2896 7 None None None 157961177 Common - flagellar hook-associated protein FlgK Spea_1349 117 COG1256 FlgK, Flagellar hook-associated protein Cell motility and secretion 157961319 Common - ferredoxin, 2Fe-2S type, ISC system Spea_1493 78 COG0633 Fdx, Ferredoxin Energy production and conversion 157960835 Common - choline dehydrogenase Spea_1007 95 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 157962478 Common - protein of unknown function DUF81 Spea_2657 172 COG0730 COG0730, Predicted permeases General function prediction only 157962442 Common - transcriptional regulator, MarR family Spea_2621 107 COG1846 MarR, Transcriptional regulators Transcription 157961953 Common - NADH:flavin oxidoreductase/NADH oxidase Spea_2132 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 157962003 Common - peptidase U32 Spea_2182 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 157961925 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Spea_2104 218 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 157963409 Common - ribosomal protein L13 Spea_3595 229 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 157959932 Common - DNA polymerase I Spea_0102 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 157961876 Common - SeqA family protein Spea_2055 23 COG3057 SeqA, Negative regulator of replication initiationR DNA replication, recombination, and repair 157962912 Common - bacterioferritin Spea_3095 98 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 157961999 Common - efflux transporter, RND family, MFP subunit Spea_2178 147 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157963772 Common - hypothetical protein Spea_3961 2 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 157962631 Common - hypothetical protein Spea_2811 3 None None None 157959849 Common - peptidase M24 Spea_0019 169 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 157963085 Common - hypothetical protein Spea_3269 30 None None None 157960114 Common - hypothetical protein Spea_0285 1 None None None 157961856 Common - hypothetical protein Spea_2035 1 None None None 157962421 Common - ATPase associated with various cellular activities AAA_3 Spea_2600 176 COG0714 COG0714, MoxR-like ATPases General function prediction only 157961757 Common - ProQ activator of osmoprotectant transporter ProP Spea_1934 35 COG3109 ProQ, Activator of osmoprotectant transporter ProP Signal transduction mechanisms 157962274 Common - peptidase M22 glycoprotease Spea_2453 193 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 157962671 Common - Peptidyl-dipeptidase Dcp Spea_2852 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 157959864 Common - protein of unknown function DUF494 Spea_0034 39 COG2922 Smg, Uncharacterized protein conserved in bacteria Function unknown 157963975 Common - 1-aminocyclopropane-1-carboxylate deaminase Spea_4164 66 COG2515 Acd, 1-aminocyclopropane-1-carboxylate deaminase Amino acid transport and metabolism 157962832 Common - amidohydrolase Spea_3014 68 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 157961093 Common - hypothetical protein Spea_1265 68 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 157963922 Common - hypothetical protein Spea_4111 2 None None None 157962609 Nonpathogen - hypothetical protein Spea_2788 1 None None None 157961188 Common - flagellar hook-basal body complex subunit FliE Spea_1360 77 COG1677 FliE, Flagellar hook-basal body protein Cell motility and secretion / Intracellular trafficking and secretion 157961285 Common - methylated-DNA--protein-cysteine methyltransferase Spea_1459 214 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 157963118 Common - glycine cleavage system H protein Spea_3302 187 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 157962348 Common - transcriptional regulator, GntR family with aminotransferase domain Spea_2527 177 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 157962162 Common - Smr protein/MutS2 Spea_2341 82 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 157962751 Common - protein of unknown function DUF1568 Spea_2933 20 None None None 157962611 Common - hypothetical protein Spea_2790 4 COG3126 COG3126, Uncharacterized protein conserved in bacteria Function unknown 157960974 Common - hypothetical protein Spea_1146 2 None None None 157961307 Common - hypothetical protein Spea_1481 13 None None None 157962700 Common - undecaprenyl diphosphate synthase Spea_2881 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 157962107 Common - Alcohol dehydrogenase GroES domain protein Spea_2286 213 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 157963335 Common - TonB family protein Spea_3521 49 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 157963611 Common - TatD-related deoxyribonuclease Spea_3799 237 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 157962155 Common - 6-phosphogluconolactonase Spea_2334 125 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 157961438 Common - D-isomer specific 2-hydroxyacid dehydrogenase catalytic region Spea_1612 230 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 157959947 Common - hypothetical protein Spea_0117 5 None None None 157961629 Common - HtpX domain protein Spea_1805 190 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 157963837 Common - hypothetical protein Spea_4026 8 None None None 157960246 Common - signaling modulator of AmpD, AmpE Spea_0417 28 COG3725 AmpE, Membrane protein required for beta-lactamase induction Defense mechanisms 157960600 Common - L-serine dehydratase 1 Spea_0772 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 157962964 Common - iojap-like protein Spea_3147 201 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 157961605 Common - efflux transporter, RND family, MFP subunit Spea_1781 175 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157960485 Nonpathogen - hypothetical protein Spea_0657 1 None None None 157960496 Common - hypothetical protein Spea_0668 8 None None None 157960644 Common - ribose 5-phosphate isomerase Spea_0816 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 157960199 Common - HemY domain protein Spea_0370 36 COG3071 HemY, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 157963634 Common - hypothetical protein Spea_3823 2 None None None 157960603 Common - sodium:dicarboxylate symporter Spea_0775 164 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 157963281 Common - transposase IS116/IS110/IS902 family protein Spea_3467 98 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 157963931 Common - molybdenum cofactor biosynthesis protein A Spea_4120 203 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 157963585 Common - diguanylate cyclase/phosphodiesterase Spea_3773 158 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 157962853 Common - SNARE associated Golgi protein Spea_3035 133 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 157960202 Common - porphobilinogen deaminase Spea_0373 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 157959913 Common - flagellar M-ring protein FliF Spea_0083 125 COG1766 FliF, Flagellar biosynthesis/type III secretory pathway lipoprotein Cell motility and secretion / Intracellular trafficking and secretion 157962516 Common - decaheme cytochrome c Spea_2695 8 None None None 157962707 Common - 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase Spea_2888 138 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 157963912 Common - Ig domain protein group 1 domain protein Spea_4101 22 None None None 157962118 Nonpathogen - hypothetical protein Spea_2297 1 None None None 157963662 Common - nucleoside transporter Spea_3851 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 157960462 Common - transcriptional regulator, LuxR family Spea_0633 129 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 157962905 Common - ATP-dependent endonuclease of the OLD family Spea_3087 42 COG3593 COG3593, Predicted ATP-dependent endonuclease of the OLD family DNA replication, recombination, and repair 157960049 Common - cytochrome C biogenesis protein Spea_0220 92 COG3088 CcmH, Uncharacterized protein involved in biosynthesis of c-type cytochromes Posttranslational modification, protein turnover, chaperones 157959993 Common - transcriptional regulator, TetR family Spea_0163 50 COG1309 AcrR, Transcriptional regulator Transcription 157960822 Common - peptidase M23B Spea_0994 187 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 157961905 Common - Domain of unknown function DUF1904 Spea_2084 7 None None None 157963816 Common - cytochrome oxidase assembly Spea_4005 44 COG1612 CtaA, Uncharacterized protein required for cytochrome oxidase assembly Posttranslational modification, protein turnover, chaperones 157960659 Common - Nitrite reductase (cytochrome; ammonia-forming) Spea_0831 40 COG3303 NrfA, Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit Inorganic ion transport and metabolism 157961260 Common - multi-sensor hybrid histidine kinase Spea_1434 224 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157962077 Common - hypothetical protein Spea_2256 4 None None None 157963083 Common - diguanylate cyclase Spea_3267 176 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 157961130 Common - radical SAM enzyme, Cfr family Spea_1302 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 157962864 Common - phosphopentomutase Spea_3046 70 COG1015 DeoB, Phosphopentomutase Carbohydrate transport and metabolism 157961415 Common - glutamine amidotransferase of anthranilate synthase Spea_1589 237 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 157961528 Common - proline racemase Spea_1703 47 COG3938 COG3938, Proline racemase Amino acid transport and metabolism 157963766 Nonpathogen - hypothetical protein Spea_3955 1 None None None 157960096 Common - S-(hydroxymethyl)glutathione synthase Spea_0267 16 COG3791 COG3791, Uncharacterized conserved protein Function unknown 157962223 Common - DNA polymerase III, epsilon subunit Spea_2402 189 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 157961265 Common - glycoside hydrolase family 3 domain protein Spea_1439 108 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 157963009 Common - diguanylate cyclase Spea_3192 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157963892 Common - hypothetical protein Spea_4081 116 COG2855 COG2855, Predicted membrane protein Function unknown 157963777 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Spea_3966 164 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 157962886 Common - ribosomal RNA methyltransferase RrmJ/FtsJ Spea_3068 138 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 157963359 Common - carbohydrate kinase, YjeF related protein Spea_3545 222 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 157960652 Common - membrane lipoprotein lipid attachment site Spea_0824 39 COG3417 FlgN, Collagen-binding surface adhesin SpaP (antigen I/II family) General function prediction only 157963042 Common - hypothetical protein Spea_3225 2 None None None 157963394 Common - alanine racemase Spea_3580 199 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 157963697 Common - hypothetical protein Spea_3886 37 None None None 157963393 Common - hypothetical protein Spea_3579 4 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 157963568 Common - MSHA biogenesis protein MshP Spea_3756 9 None None None 157963669 Common - Mandelate racemase/muconate lactonizing protein Spea_3858 124 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 157961045 Nonpathogen - hypothetical protein Spea_1217 7 COG4129 COG4129, Predicted membrane protein Function unknown 157963323 Common - transcriptional regulator, Crp/Fnr family Spea_3509 166 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 157961915 Common - integrase family protein Spea_2094 53 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 157963869 Common - AbgT putative transporter Spea_4058 42 COG2978 AbgT, Putative p-aminobenzoyl-glutamate transporter Coenzyme metabolism 157962195 Common - hypothetical protein Spea_2374 3 None None None 157961694 Common - hypothetical protein Spea_1870 9 None None None 157959927 Common - hypothetical protein Spea_0097 8 None None None 157961238 Common - glycosyl transferase family 2 Spea_1411 34 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 157960677 Common - arginine repressor, ArgR Spea_0849 76 COG1438 ArgR, Arginine repressor Transcription 157962549 Common - pseudouridine synthase Spea_2728 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 157962209 Common - major facilitator superfamily MFS_1 Spea_2388 63 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 157961869 Common - aminotransferase class I and II Spea_2048 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 157960445 Common - transcriptional regulator, AraC family Spea_0616 97 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 157962318 Common - fatty acid/phospholipid synthesis protein PlsX Spea_2497 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 157961909 Common - two component transcriptional regulator, LuxR family Spea_2088 210 COG4566 TtrR, Response regulator Signal transduction mechanisms 157961034 Common - sodium:dicarboxylate symporter Spea_1206 164 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 157962496 Common - ABC transporter related Spea_2675 249 COG4167 SapF, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 157961112 Common - protein of unknown function UPF0125 Spea_1284 64 COG2914 COG2914, Uncharacterized protein conserved in bacteria Function unknown 157961296 Common - queuine tRNA-ribosyltransferase Spea_1470 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 157963517 Common - hypothetical protein Spea_3705 2 None None None 157960520 Common - hypothetical protein Spea_0692 1 None None None 157963230 Nonpathogen - hypothetical protein Spea_3416 1 None None None 157960517 Common - ABC transporter related Spea_0689 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 157960915 Common - type IV pilus modification protein PilV Spea_1087 14 COG4967 PilV, Tfp pilus assembly protein PilV Cell motility and secretion / Intracellular trafficking and secretion 157962841 Common - methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor Spea_3023 101 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157960039 Common - ribosomal protein L17 Spea_0210 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 157963373 Common - protein of unknown function UPF0227 Spea_3559 50 COG3150 COG3150, Predicted esterase General function prediction only 157963659 Common - domain of unknown function DUF1732 Spea_3848 137 COG1561 COG1561, Uncharacterized stress-induced protein Function unknown 157961686 Common - TonB-dependent receptor plug Spea_1862 84 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 157960310 Common - peptidylprolyl isomerase FKBP-type Spea_0481 136 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 157962189 Common - putative methyltransferase Spea_2368 54 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 157961814 Common - PTS system, glucose subfamily, IIA subunit Spea_1993 61 COG2190 NagE, Phosphotransferase system IIA components Carbohydrate transport and metabolism 157961715 Common - hypothetical protein Spea_1892 7 None None None 157961147 Common - cytochrome d ubiquinol oxidase, subunit II Spea_1319 156 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 157961480 Nonpathogen - hypothetical protein Spea_1654 2 None None None 157963309 Common - hypothetical protein Spea_3495 3 None None None 157960510 Common - transposase Spea_0682 9 None None None 157961761 Common - protein of unknown function DUF1302 Spea_1938 18 None None None 157960000 Common - translation elongation factor Tu Spea_0170 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 157963002 Common - protein of unknown function DUF1456 Spea_3185 31 COG4807 COG4807, Uncharacterized protein conserved in bacteria Function unknown 157961423 Common - PEBP family protein Spea_1597 125 COG1881 COG1881, Phospholipid-binding protein General function prediction only 157963644 Common - hypothetical protein Spea_3833 2 None None None 157962380 Common - type III restriction protein res subunit Spea_2559 150 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 157961834 Common - type II and III secretion system protein Spea_2013 140 COG4964 CpaC, Flp pilus assembly protein, secretin CpaC Intracellular trafficking and secretion 157960634 Common - thiol:disulfide interchange protein DsbC Spea_0806 68 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 157962540 Common - diguanylate cyclase Spea_2719 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157960185 Common - protein of unknown function DUF526 Spea_0356 53 COG2960 COG2960, Uncharacterized protein conserved in bacteria Function unknown 157963872 Common - efflux transporter, RND family, MFP subunit Spea_4061 158 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157960711 Common - Protein of unknown function DUF1971 Spea_0883 26 COG3615 TehB, Uncharacterized protein/domain, possibly involved in tellurite resistance Inorganic ion transport and metabolism 157962070 Common - hypothetical protein Spea_2249 3 None None None 157959989 Common - major facilitator superfamily MFS_1 Spea_0159 77 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 157960141 Common - protein of unknown function DUF1107 Spea_0312 3 None None None 157960529 Common - transcriptional regulator, CadC Spea_0701 9 COG3710 CadC, DNA-binding winged-HTH domains Transcription 157963754 Common - hypothetical protein Spea_3943 14 None None None 157960756 Common - transcriptional regulator, ArsR family Spea_0928 61 COG0640 ArsR, Predicted transcriptional regulators Transcription 157960287 Common - hypothetical protein Spea_0458 4 None None None 157963095 Common - cation antiporter Spea_3279 29 COG1863 MnhE, Multisubunit Na+/H+ antiporter, MnhE subunit Inorganic ion transport and metabolism 157960058 Common - ornithine carbamoyltransferase Spea_0229 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 157960188 Common - transcriptional regulator, TetR family Spea_0359 75 COG1309 AcrR, Transcriptional regulator Transcription 157962186 Common - protein of unknown function DUF28 Spea_2365 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 157960774 Common - extracellular solute-binding protein family 1 Spea_0946 132 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 157963188 Nonpathogen - hypothetical protein Spea_3373 2 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 157963207 Common - adenosine deaminase Spea_3392 110 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 157963538 Common - hypothetical protein Spea_3726 1 None None None 157960561 Common - two component transcriptional regulator, winged helix family Spea_0733 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157960796 Common - rRNA (guanine-N(1)-)-methyltransferase Spea_0968 49 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 157961490 Common - protein of unknown function UPF0118 Spea_1665 181 COG0628 PerM, Predicted permease General function prediction only 157962493 Common - binding-protein-dependent transport systems inner membrane component Spea_2672 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 157962799 Common - hypothetical protein Spea_2981 46 COG2933 COG2933, Predicted SAM-dependent methyltransferase General function prediction only 157960903 Common - OmpA/MotB domain protein Spea_1075 128 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 157962554 Common - 3-beta hydroxysteroid dehydrogenase/isomerase Spea_2733 184 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 157960724 Common - AMMECR1 domain protein Spea_0896 68 COG2078 AMMECR1, Uncharacterized conserved protein Function unknown 157960845 Common - Integrase catalytic region Spea_1017 134 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157963056 Common - Endothelin-converting enzyme 1 Spea_3239 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 157960566 Common - pseudouridine synthase Spea_0738 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 157961386 Common - protein of unknown function DUF437 Spea_1560 16 COG3097 COG3097, Uncharacterized protein conserved in bacteria Function unknown 157963142 Common - protein of unknown function DUF1008 Spea_3326 18 COG3721 HugX, Putative heme iron utilization protein Inorganic ion transport and metabolism 157963200 Common - TonB-dependent receptor Spea_3385 112 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 157961573 Common - binding-protein-dependent transport systems inner membrane component Spea_1749 85 COG3639 COG3639, ABC-type phosphate/phosphonate transport system, permease component Inorganic ion transport and metabolism 157961537 Common - D,D-heptose 1,7-bisphosphate phosphatase Spea_1712 131 COG0241 HisB, Histidinol phosphatase and related phosphatases Amino acid transport and metabolism 157963484 Common - methyl-accepting chemotaxis sensory transducer Spea_3672 135 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157962125 Common - hypothetical protein Spea_2304 6 COG3513 COG3513, Uncharacterized protein conserved in bacteria Function unknown 157961565 Nonpathogen - hypothetical protein Spea_1741 5 None None None 157963639 Common - 2-isopropylmalate synthase Spea_3828 217 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 157962219 Common - methyl-accepting chemotaxis sensory transducer Spea_2398 161 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157963676 Nonpathogen - hypothetical protein Spea_3865 1 None None None 157961343 Common - regulatory protein GntR HTH Spea_1517 129 COG2186 FadR, Transcriptional regulators Transcription 157960166 Common - methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor Spea_0337 158 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157962534 Common - Gluconate transporter Spea_2713 80 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 157963830 Common - methyl-accepting chemotaxis sensory transducer Spea_4019 124 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157960042 Common - heme exporter protein CcmC Spea_0213 111 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 157963165 Common - Ion transport protein Spea_3349 26 None None None 157963963 Common - multiple antibiotic resistance (MarC)-related protein Spea_4152 152 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 157960592 Common - peptidase U32 Spea_0764 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 157963583 Common - Fimbrial assembly family protein Spea_3771 4 COG3166 PilN, Tfp pilus assembly protein PilN Cell motility and secretion / Intracellular trafficking and secretion 157961852 Common - Ni/Fe-hydrogenase, b-type cytochrome subunit Spea_2031 46 COG1969 HyaC, Ni,Fe-hydrogenase I cytochrome b subunit Energy production and conversion 157962629 Common - two component transcriptional regulator, winged helix family Spea_2809 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157961499 Common - formate/nitrite transporter Spea_1674 121 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 157961464 Common - exodeoxyribonuclease III Spea_1638 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 157961321 Common - Integrase catalytic region Spea_1495 142 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157962511 Common - ferrous iron transport protein B Spea_2690 163 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 157962790 Common - peptidase M61 domain protein Spea_2972 57 COG3975 COG3975, Predicted protease with the C-terminal PDZ domain General function prediction only 157961042 Common - hypothetical protein Spea_1214 4 None None None 157961151 Common - protein of unknown function DUF465 Spea_1323 29 COG2841 COG2841, Uncharacterized protein conserved in bacteria Function unknown 157961022 Common - DNA mismatch repair protein MutS Spea_1194 204 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 157961135 Common - tetratricopeptide TPR_4 Spea_1307 57 COG2976 COG2976, Uncharacterized protein conserved in bacteria Function unknown 157960918 Common - type IV pilin biogenesis protein, putative Spea_1090 33 COG3419 PilY1, Tfp pilus assembly protein, tip-associated adhesin PilY1 Cell motility and secretion / Intracellular trafficking and secretion 157961137 Common - small GTP-binding protein Spea_1309 229 COG1160 COG1160, Predicted GTPases General function prediction only 157961204 Common - GTP-binding signal recognition particle SRP54 G- domain Spea_1376 176 COG1419 FlhF, Flagellar GTP-binding protein Cell motility and secretion 157962647 Nonpathogen - BRCT domain protein Spea_2827 2 COG4886 COG4886, Leucine-rich repeat (LRR) protein Function unknown 157961313 Common - transcriptional regulator, BadM/Rrf2 family Spea_1487 172 COG1959 COG1959, Predicted transcriptional regulator Transcription 157961154 Common - transcriptional regulator, TetR family Spea_1326 124 COG1309 AcrR, Transcriptional regulator Transcription 157963996 Common - thioesterase superfamily protein Spea_4185 41 COG0824 FcbC, Predicted thioesterase General function prediction only 157961444 Common - FolC bifunctional protein Spea_1618 217 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 157963428 Common - Cell envelope biogenesis YhbN Spea_3614 47 COG1934 COG1934, Uncharacterized protein conserved in bacteria Function unknown 157961653 Common - hypothetical protein Spea_1829 9 None None None 157960852 Common - Thymidylate synthase Spea_1024 136 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 157963226 Common - diguanylate cyclase Spea_3412 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157962050 Common - seryl-tRNA synthetase Spea_2229 244 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 157963809 Common - hypothetical protein Spea_3998 20 COG5404 SulA, SOS-response cell division inhibitor, blocks FtsZ ring formation Cell division and chromosome partitioning 157960404 Common - hypothetical protein Spea_0575 1 None None None 157962564 Common - phosphate ABC transporter, ATPase subunit Spea_2743 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 157960292 Common - band 7 protein Spea_0463 217 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 157963730 Common - transcriptional regulator, XRE family Spea_3919 13 COG1396 HipB, Predicted transcriptional regulators Transcription 157963447 Common - 23S rRNA (uracil-5-)-methyltransferase RumB Spea_3635 185 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 157962969 Common - rare lipoprotein A Spea_3152 137 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 157962927 Common - Uncharacterized lipoprotein Spea_3110 18 COG3056 COG3056, Uncharacterized lipoprotein Cell envelope biogenesis, outer membrane 157960065 Common - Pilus assembly protein PilP Spea_0236 37 COG3168 PilP, Tfp pilus assembly protein PilP Cell motility and secretion / Intracellular trafficking and secretion 157961007 Common - protein of unknown function DUF416 Spea_1179 26 COG3068 COG3068, Uncharacterized protein conserved in bacteria Function unknown 157964034 Common - Cytochrome c oxidase cbb3 type accessory protein FixG Spea_4223 83 COG0348 NapH, Polyferredoxin Energy production and conversion 157962146 Common - diguanylate cyclase Spea_2325 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157963108 Nonpathogen - hypothetical protein Spea_3292 1 None None None 157959872 Common - carbonic anhydrase, family 3 Spea_0042 188 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 157960985 Common - metallophosphoesterase Spea_1157 12 None None None 157960322 Common - Lysine exporter protein (LYSE/YGGA) Spea_0493 119 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 157960871 Common - Dyp-type peroxidase family Spea_1043 52 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 157961665 Common - protein of unknown function DUF214 Spea_1841 171 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 157963688 Common - Guanylate kinase Spea_3877 213 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 157960357 Nonpathogen - hypothetical protein Spea_0528 1 None None None 157962027 Common - amino acid permease-associated region Spea_2206 178 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 157961013 Common - Phosphopyruvate hydratase Spea_1185 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 157962134 Common - type III restriction protein res subunit Spea_2313 76 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 157962415 Common - hypothetical protein Spea_2594 1 None None None 157963130 Common - uracil-DNA glycosylase Spea_3314 129 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 157960348 Common - transcriptional regulator, LacI family Spea_0519 127 COG1609 PurR, Transcriptional regulators Transcription 157962742 Common - hypothetical protein Spea_2924 23 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 157963179 Common - ABC transporter related Spea_3364 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 157963531 Common - MscS Mechanosensitive ion channel Spea_3719 203 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 157962951 Common - Aminoacyl-tRNA hydrolase Spea_3134 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 157962055 Common - transcriptional regulator, AsnC family Spea_2234 158 COG1522 Lrp, Transcriptional regulators Transcription 157960553 Common - basic membrane lipoprotein Spea_0725 106 COG1744 Med, Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein General function prediction only 157962022 Common - hypothetical protein Spea_2201 22 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 157962595 Common - peptidase S9 prolyl oligopeptidase active site domain protein Spea_2774 109 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 157962661 Common - hypothetical protein Spea_2842 6 COG4287 PqaA, PhoPQ-activated pathogenicity-related protein General function prediction only 157960158 Common - phospholipid/glycerol acyltransferase Spea_0329 31 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 157961794 Common - peptidase M48 Ste24p Spea_1971 126 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 157963274 Common - hypothetical protein Spea_3460 4 COG1831 COG1831, Predicted metal-dependent hydrolase (urease superfamily) General function prediction only 157960954 Common - pyrroline-5-carboxylate reductase Spea_1126 210 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 157961407 Common - NADH:ubiquinone oxidoreductase, subunit F Spea_1581 4 COG2871 NqrF, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF Energy production and conversion 157960754 Common - Ig domain protein group 2 domain protein Spea_0926 21 None None None 157963788 Common - RNA polymerase, sigma 32 subunit, RpoH Spea_3977 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 157962977 Common - hypothetical protein Spea_3160 8 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 157960809 Common - oxidoreductase molybdopterin binding Spea_0981 64 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 157961780 Common - Peptidoglycan-binding domain 1 protein Spea_1957 74 COG2989 COG2989, Uncharacterized protein conserved in bacteria Function unknown 157960170 Common - transcriptional regulator, LysR family Spea_0341 63 COG0583 LysR, Transcriptional regulator Transcription 157963011 Common - putative iron-sulfur cluster binding protein Spea_3194 126 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 157960735 Common - protein of unknown function DUF21 Spea_0907 218 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 157963246 Common - hypothetical protein Spea_3432 12 None None None 157962479 Common - primosomal replication protein N'', putative Spea_2658 7 COG3923 PriC, Primosomal replication protein N'' DNA replication, recombination, and repair 157962598 Common - short-chain dehydrogenase/reductase SDR Spea_2777 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157962971 Common - protein of unknown function DUF493 Spea_3154 42 COG2921 COG2921, Uncharacterized conserved protein Function unknown 157962521 Common - outer membrane protein precursor MtrB Spea_2700 9 None None None 157963000 Common - putative manganese transporter Spea_3183 18 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 157963264 Common - gluconate transporter Spea_3450 78 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 157963628 Common - Peptidoglycan glycosyltransferase Spea_3817 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 157960025 Common - ribosomal protein L24 Spea_0195 210 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 157963606 Common - 2-polyprenylphenol 6-hydroxylase Spea_3794 184 COG0661 AarF, Predicted unusual protein kinase General function prediction only 157963440 Common - glycosyl transferase family 39 Spea_3628 69 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 157963900 Common - isochorismate synthase Spea_4089 222 COG1169 MenF, Isochorismate synthase Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism 157960882 Common - chorismate mutase Spea_1054 81 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 157960624 Common - putative diguanylate cyclase Spea_0796 8 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157962920 Common - NADH:ubiquinone oxidoreductase, subunit A Spea_3103 40 COG1726 NqrA, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA Energy production and conversion 157960192 Common - hypothetical protein Spea_0363 32 COG3672 COG3672, Predicted periplasmic protein Function unknown 157960151 Common - hypothetical protein Spea_0322 19 None None None 157962681 Common - UspA domain protein Spea_2862 92 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 157963383 Common - hypothetical protein Spea_3569 1 None None None 157963113 Nonpathogen - hypothetical protein Spea_3297 1 None None None 157962816 Common - protein of unknown function DUF162 Spea_2998 28 COG1556 COG1556, Uncharacterized conserved protein Function unknown 157963708 Common - hypothetical protein Spea_3897 45 COG4258 COG4258, Predicted exporter General function prediction only 157963139 Nonpathogen - hypothetical protein Spea_3323 1 None None None 157959882 Common - acylneuraminate cytidylyltransferase Spea_0052 106 COG1083 NeuA, CMP-N-acetylneuraminic acid synthetase Cell envelope biogenesis, outer membrane 157963973 Common - hypothetical protein Spea_4162 3 None None None 157961250 Common - glycosyl transferase, WecB/TagA/CpsF family Spea_1424 185 COG1922 WecG, Teichoic acid biosynthesis proteins Cell envelope biogenesis, outer membrane 157959855 Common - transcriptional regulator, ArsR family Spea_0025 161 COG0640 ArsR, Predicted transcriptional regulators Transcription 157959977 Common - general secretion pathway protein G Spea_0147 106 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 157961944 Common - beta-lactamase domain protein Spea_2123 75 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 157959930 Common - cytochrome c class I Spea_0100 63 COG2863 COG2863, Cytochrome c553 Energy production and conversion 157963008 Common - phosphoesterase PA-phosphatase related Spea_3191 32 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 157962111 Common - phospholipase A1 Spea_2290 52 COG2829 PldA, Outer membrane phospholipase A Cell envelope biogenesis, outer membrane 157960752 Common - OmpA/MotB domain protein Spea_0924 150 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 157960070 Common - DNA adenine methylase Spea_0241 100 COG0338 Dam, Site-specific DNA methylase DNA replication, recombination, and repair 157961226 Common - glucose-1-phosphate thymidylyltransferase Spea_1399 233 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 157962710 Common - pseudouridine synthase Spea_2891 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 157960252 Common - Patatin Spea_0423 126 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 157964064 Common - Inosine/uridine-preferring nucleoside hydrolase Spea_4253 86 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 157961634 Common - response regulator receiver and ANTAR domain protein Spea_1810 5 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 157961889 Common - beta-lactamase Spea_2068 134 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 157960480 Common - alanine dehydrogenase/PNT domain protein Spea_0652 166 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 157960001 Common - preprotein translocase, SecE subunit Spea_0171 71 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 157962045 Common - PP-loop domain protein Spea_2224 162 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 157962112 Common - excinuclease ABC, B subunit Spea_2291 233 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 157962240 Common - exodeoxyribonuclease V, gamma subunit Spea_2419 70 COG1330 RecC, Exonuclease V gamma subunit DNA replication, recombination, and repair 157962388 Common - Tol-Pal system TolQ Spea_2567 150 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 157963037 Common - protein of unknown function DUF1704 Spea_3220 17 COG3930 COG3930, Uncharacterized protein conserved in bacteria Function unknown 157962370 Common - phosphoenolpyruvate synthase Spea_2549 235 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 157959939 Common - Three-deoxy-D-manno-octulosonic-acid transferase domain protein Spea_0109 128 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 157962910 Nonpathogen - hypothetical protein Spea_3093 1 None None None 157960503 Common - pseudouridine synthase Spea_0675 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 157961275 Common - transcriptional coactivator/pterin dehydratase Spea_1449 83 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 157960687 Common - methyl-accepting chemotaxis sensory transducer Spea_0859 147 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157963249 Common - hypothetical protein Spea_3435 4 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 157961450 Nonpathogen - hypothetical protein Spea_1624 1 None None None 157963298 Common - hypothetical protein Spea_3484 6 None None None 157962804 Common - thiamine biosynthesis/tRNA modification protein ThiI Spea_2986 94 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 157963124 Common - protein of unknown function DUF710 Spea_3308 59 COG3027 COG3027, Uncharacterized protein conserved in bacteria Function unknown 157963888 Common - peptidase M24 Spea_4077 247 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 157961588 Common - protein of unknown function DUF1414 Spea_1764 21 COG3082 COG3082, Uncharacterized protein conserved in bacteria Function unknown 157963546 Common - amino acid carrier protein Spea_3734 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 157961270 Common - protein of unknown function DUF583 Spea_1444 36 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 157962867 Common - nucleoside-specific channel-forming protein Tsx Spea_3049 18 COG3248 Tsx, Nucleoside-binding outer membrane protein Cell envelope biogenesis, outer membrane 157961941 Common - aldehyde dehydrogenase Spea_2120 219 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 157963927 Common - molybdopterin biosynthesis MoaE protein Spea_4116 159 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 157960299 Nonpathogen - hypothetical protein Spea_0470 1 None None None 157961931 Common - DsrE family protein Spea_2110 42 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 157962988 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Spea_3171 172 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 157961619 Common - GCN5-related N-acetyltransferase Spea_1795 88 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 157963438 Nonpathogen - putative FG-GAP repeat lipoprotein Spea_3626 2 None None None 157962033 Common - hypothetical protein Spea_2212 1 None None None 157961874 Common - hypothetical protein Spea_2053 8 None None None 157960717 Common - pseudouridine synthase Spea_0889 165 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 157962245 Common - transposase Spea_2424 9 None None None 157963073 Common - hypothetical protein Spea_3256 3 None None None 157962917 Common - NADH:ubiquinone oxidoreductase, subunit D Spea_3100 76 COG1347 NqrD, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD Energy production and conversion 157960969 Common - protein of unknown function UPF0126 Spea_1141 133 COG2860 COG2860, Predicted membrane protein Function unknown 157962834 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Spea_3016 110 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 157962292 Common - methyl-accepting chemotaxis sensory transducer Spea_2471 148 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157963915 Common - formamidopyrimidine-DNA glycosylase Spea_4104 182 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 157959905 Common - flagellar basal-body rod protein FlgB Spea_0075 69 COG1815 FlgB, Flagellar basal body protein Cell motility and secretion 157963341 Common - hypothetical protein Spea_3527 5 None None None 157963374 Common - Calcineurin phosphoesterase domain protein Spea_3560 79 COG1409 Icc, Predicted phosphohydrolases General function prediction only 157961846 Common - hydrogenase expression/formation protein HypD Spea_2025 109 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 157963348 Common - cytochrome c1 Spea_3534 84 COG2857 CYT1, Cytochrome c1 Energy production and conversion 157963030 Common - extracellular solute-binding protein family 3 Spea_3213 160 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 157960416 Common - hypothetical protein Spea_0587 1 None None None 157962480 Common - hypothetical protein Spea_2659 6 COG3110 COG3110, Uncharacterized protein conserved in bacteria Function unknown 157961067 Common - extracellular solute-binding protein family 3 Spea_1239 139 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 157961691 Nonpathogen - hypothetical protein Spea_1867 1 None None None 157962728 Common - Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ Spea_2909 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 157959917 Common - hypothetical protein Spea_0087 3 COG1868 FliM, Flagellar motor switch protein Cell motility and secretion 157961259 Common - phosphonate ABC transporter, periplasmic phosphonate-binding protein Spea_1433 53 COG3221 PhnD, ABC-type phosphate/phosphonate transport system, periplasmic component Inorganic ion transport and metabolism 157963749 Common - tetraheme cytochrome c Spea_3938 4 None None None 157961882 Common - hypothetical protein Spea_2061 2 None None None 157960212 Common - protein of unknown function DUF542 ScdA domain protein Spea_0383 45 COG2846 COG2846, Regulator of cell morphogenesis and NO signaling Cell division and chromosome partitioning 157962674 Common - Electron transfer flavoprotein alpha/beta-subunit Spea_2855 153 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 157962820 Common - hypothetical protein Spea_3002 3 None None None 157961347 Common - glucosamine-6-phosphate isomerase Spea_1521 97 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 157959899 Common - flagellar L-ring protein Spea_0069 97 COG2063 FlgH, Flagellar basal body L-ring protein Cell motility and secretion 157963716 Common - thioesterase domain, putative Spea_3905 34 None None None 157961928 Common - DsrC family protein Spea_2107 60 COG2920 DsrC, Dissimilatory sulfite reductase (desulfoviridin), gamma subunit Inorganic ion transport and metabolism 157963823 Common - competence protein ComF Spea_4012 145 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 157960790 Common - putative metalloendopeptidase, glycoprotease family Spea_0962 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 157961340 Common - Kelch repeat-containing protein Spea_1514 16 COG3055 COG3055, Uncharacterized protein conserved in bacteria Function unknown 157962166 Common - hypothetical protein Spea_2345 2 None None None 157960991 Common - riboflavin synthase, alpha subunit Spea_1163 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 157962538 Common - transcriptional regulator, AraC family Spea_2717 57 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 157963417 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase Spea_3603 223 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 157961157 Common - Methyltransferase type 11 Spea_1329 53 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 157960013 Common - ribosomal protein S10 Spea_0183 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 157962785 Common - phosphate binding protein Spea_2967 117 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 157960775 Common - spermidine/putrescine ABC transporter ATPase subunit Spea_0947 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 157963047 Nonpathogen - hypothetical protein Spea_3230 1 None None None 157962216 Nonpathogen - hypothetical protein Spea_2395 1 None None None 157962102 Common - YdaE Spea_2281 5 COG3822 COG3822, ABC-type sugar transport system, auxiliary component General function prediction only 157960010 Common - ribosomal protein S7 Spea_0180 238 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 157961287 Common - dual specificity protein phosphatase Spea_1461 8 COG2453 CDC14, Predicted protein-tyrosine phosphatase Signal transduction mechanisms 157961864 Common - malate synthase G Spea_2043 71 COG2225 AceB, Malate synthase Energy production and conversion 157960944 Nonpathogen - hypothetical protein Spea_1116 1 None None None 157962487 Common - protein of unknown function DUF463 YcjX family protein Spea_2666 42 COG3106 COG3106, Predicted ATPase General function prediction only 157959874 Nonpathogen - hypothetical protein Spea_0044 1 None None None 157961591 Common - peptidase M23B Spea_1767 185 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 157961766 Common - Dihydroorotate oxidase Spea_1943 231 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 157961475 Common - short-chain dehydrogenase/reductase SDR Spea_1649 208 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157960539 Common - FMN-binding domain protein Spea_0711 8 None None None 157962514 Common - outer membrane protein, putative Spea_2693 9 None None None 157961947 Common - AMP-dependent synthetase and ligase Spea_2126 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 157960620 Common - protein of unknown function DUF481 Spea_0792 35 COG3137 COG3137, Putative salt-induced outer membrane protein Cell envelope biogenesis, outer membrane 157960027 Common - ribosomal protein S14 Spea_0197 207 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 157963769 Common - hypothetical protein Spea_3958 1 None None None 157960887 Common - chorismate mutase Spea_1059 222 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 157962615 Common - 6-phosphogluconate dehydrogenase, decarboxylating Spea_2794 140 COG0362 Gnd, 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 157963507 Common - efflux transporter, RND family, MFP subunit Spea_3695 167 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157964048 Common - UDP-N-acetylglucosamine pyrophosphorylase Spea_4237 235 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 157960177 Common - dihydroxy-acid dehydratase Spea_0348 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 157961471 Common - Sua5/YciO/YrdC/YwlC family protein Spea_1645 201 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 157963771 Common - Sel1 domain protein repeat-containing protein Spea_3960 62 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 157961568 Common - 2OG-Fe(II) oxygenase Spea_1744 10 None None None 157962057 Common - two component transcriptional regulator, winged helix family Spea_2236 207 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157961551 Common - transcriptional regulator, LysR family Spea_1727 105 COG0583 LysR, Transcriptional regulator Transcription 157961854 Common - hydrogenase (NiFe) small subunit HydA Spea_2033 77 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 157961298 Common - protein-export membrane protein SecD Spea_1472 214 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 157963237 Common - GCN5-related N-acetyltransferase Spea_3423 8 COG0456 RimI, Acetyltransferases General function prediction only 157959955 Common - Catalase Spea_0125 126 COG0753 KatE, Catalase Inorganic ion transport and metabolism 157960059 Common - Argininosuccinate synthase Spea_0230 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 157962476 Common - DNA polymerase B region Spea_2655 66 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 157963982 Common - imidazolonepropionase Spea_4171 105 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 157963426 Common - 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family Spea_3612 102 COG1778 COG1778, Low specificity phosphatase (HAD superfamily) General function prediction only 157961374 Common - hypothetical protein Spea_1548 16 None None None 157962836 Common - Sterol-binding domain protein Spea_3018 32 COG3154 COG3154, Putative lipid carrier protein Lipid metabolism 157962407 Common - ATP-NAD/AcoX kinase Spea_2586 26 COG3199 COG3199, Uncharacterized conserved protein Function unknown 157960213 Nonpathogen - hypothetical protein Spea_0384 1 None None None 157962297 Common - YceI family protein Spea_2476 13 COG2353 COG2353, Uncharacterized conserved protein Function unknown 157963740 Common - signal transduction histidine kinase, nitrogen specific, NtrB Spea_3929 221 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 157962923 Common - 2OG-Fe(II) oxygenase Spea_3106 39 COG3145 AlkB, Alkylated DNA repair protein DNA replication, recombination, and repair 157963616 Common - hypothetical protein Spea_3805 13 COG4701 COG4701, Uncharacterized protein conserved in bacteria Function unknown 157960574 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Spea_0746 219 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 157960458 Common - response regulator receiver modulated metal dependent phosphohydrolase Spea_0629 224 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 157963609 Common - Sec-independent protein translocase, TatC subunit Spea_3797 205 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 157963641 Common - ATP-dependent DNA helicase RecQ Spea_3830 238 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 157960417 Common - Thiopurine S-methyltransferase Spea_0588 31 None None None 157963242 Common - transcriptional regulator, LysR family Spea_3428 167 COG0583 LysR, Transcriptional regulator Transcription 157963310 Common - hypothetical protein Spea_3496 14 None None None 157962365 Common - hypothetical protein Spea_2544 1 None None None 157960373 Common - aminotransferase class V Spea_0544 236 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 157961363 Common - transcriptional regulator, LysR family Spea_1537 186 COG0583 LysR, Transcriptional regulator Transcription 157961934 Common - drug resistance transporter, Bcr/CflA subfamily Spea_2113 177 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 157959837 Common - glycyl-tRNA synthetase, alpha subunit Spea_0007 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 157961164 Common - anti-sigma-28 factor, FlgM Spea_1336 13 COG2747 FlgM, Negative regulator of flagellin synthesis (anti-sigma28 factor) Transcription / Cell motility and secretion / Intracellular trafficking and secretion 157961890 Common - phosphoserine aminotransferase Spea_2069 108 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 157963321 Common - Phosphoribulokinase Spea_3507 51 COG3954 PrkB, Phosphoribulokinase Energy production and conversion 157960350 Common - UbiD family decarboxylase Spea_0521 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 157962762 Common - nucleoside-diphosphate-sugar epimerase Spea_2944 44 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 157961025 Common - carbon storage regulator, CsrA Spea_1197 81 COG1551 CsrA, Carbon storage regulator (could also regulate swarming and quorum sensing) Signal transduction mechanisms 157961730 Common - Carboxylesterase Spea_1907 90 COG0400 COG0400, Predicted esterase General function prediction only 157961541 Common - nucleoside transporter Spea_1717 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 157960515 Common - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Spea_0687 152 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 157962332 Common - ATP dependent DNA ligase Spea_2511 31 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 157963407 Common - hypothetical protein Spea_3593 2 COG3242 COG3242, Uncharacterized protein conserved in bacteria Function unknown 157960365 Common - hypothetical protein Spea_0536 2 None None None 157961784 Common - protein of unknown function DUF444 Spea_1961 71 COG2718 COG2718, Uncharacterized conserved protein Function unknown 157960580 Common - FAD dependent oxidoreductase Spea_0752 135 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 157962579 Nonpathogen - hypothetical protein Spea_2758 2 None None None 157960666 Common - hypothetical protein Spea_0838 1 None None None 157961338 Nonpathogen - hypothetical protein Spea_1512 1 None None None 157960085 Common - binding-protein-dependent transport systems inner membrane component Spea_0256 143 COG4176 ProW, ABC-type proline/glycine betaine transport system, permease component Amino acid transport and metabolism 157962468 Common - Tetratricopeptide domain protein Spea_2647 22 None None None 157961331 Common - hypothetical protein Spea_1505 3 None None None 157962846 Common - ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Spea_3028 15 None None None 157962173 Common - diguanylate cyclase/phosphodiesterase Spea_2352 161 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 157960112 Common - hypothetical protein Spea_0283 11 COG2930 COG2930, Uncharacterized conserved protein Function unknown 157960359 Common - hypothetical protein Spea_0530 32 COG3531 COG3531, Predicted protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 157961389 Common - acriflavin resistance protein Spea_1563 182 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 157962231 Common - regulator of ribonuclease activity A Spea_2410 95 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 157963977 Common - putative endoribonuclease L-PSP Spea_4166 185 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 157960289 Common - uridine phosphorylase Spea_0460 97 COG2820 Udp, Uridine phosphorylase Nucleotide transport and metabolism 157963897 Nonpathogen - cobalt transport protein Spea_4086 3 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 157962346 Common - Glutathione S-transferase domain Spea_2525 30 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 157959831 Common - chromosomal replication initiator protein DnaA Spea_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 157959887 Common - RNA polymerase, sigma 28 subunit, FliA/WhiG Spea_0057 150 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 157962005 Nonpathogen - hypothetical protein Spea_2184 3 COG3531 COG3531, Predicted protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 157960811 Common - Chloride channel core Spea_0983 102 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 157959967 Common - peptidase M14 carboxypeptidase A Spea_0137 21 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 157962276 Common - helicase c2 Spea_2455 141 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 157961091 Common - hypothetical protein Spea_1263 6 None None None 157960383 Common - sulphate transporter Spea_0554 19 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 157960338 Common - NosL family protein Spea_0509 31 COG4314 NosL, Predicted lipoprotein involved in nitrous oxide reduction Energy production and conversion 157963924 Common - ABC transporter related Spea_4113 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 157961179 Common - flagellin domain protein Spea_1351 130 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 157963177 Common - protein of unknown function DUF214 Spea_3362 22 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 157962431 Common - efflux transporter, RND family, MFP subunit Spea_2610 145 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157961409 Nonpathogen - hypothetical protein Spea_1583 2 None None None 157959922 Common - flagellar biosynthetic protein FlhB Spea_0092 130 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 157961368 Common - hypothetical protein Spea_1542 8 None None None 157963021 Common - putative signal transduction protein Spea_3204 1 COG3434 COG3434, Predicted signal transduction protein containing EAL and modified HD-GYP domains Signal transduction mechanisms 157963028 Common - NADPH-dependent FMN reductase Spea_3211 47 COG0431 COG0431, Predicted flavoprotein General function prediction only 157960120 Common - hypothetical protein Spea_0291 9 None None None 157961431 Common - FAD dependent oxidoreductase Spea_1605 50 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 157962717 Common - hypothetical protein Spea_2898 5 COG2913 SmpA, Small protein A (tmRNA-binding) Translation, ribosomal structure and biogenesis 157961059 Common - beta-lactamase domain protein Spea_1231 44 COG2015 COG2015, Alkyl sulfatase and related hydrolases Secondary metabolites biosynthesis, transport, and catabolism 157963087 Common - Mn2+ and Fe2+ transporter of the NRAMP family Spea_3271 34 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 157963369 Common - BFD domain protein (2Fe-2S)-binding domain protein Spea_3555 34 COG2906 Bfd, Bacterioferritin-associated ferredoxin Inorganic ion transport and metabolism 157961969 Common - short-chain dehydrogenase/reductase SDR Spea_2148 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157962394 Common - Integrase catalytic region Spea_2573 136 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157960613 Nonpathogen - hypothetical protein Spea_0785 1 None None None 157961955 Common - Electron transfer flavoprotein alpha subunit Spea_2134 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 157961098 Common - DNA-cytosine methyltransferase Spea_1270 120 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 157962758 Common - hypothetical protein Spea_2940 14 None None None 157964024 Common - transposase IS116/IS110/IS902 family protein Spea_4213 98 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 157960763 Common - methylmalonate-semialdehyde dehydrogenase Spea_0935 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 157960819 Common - TonB-dependent receptor Spea_0991 110 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 157963523 Common - diguanylate cyclase Spea_3711 179 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157962748 Common - TonB-dependent receptor plug Spea_2930 117 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 157963231 Common - lipoprotein, putative Spea_3417 1 None None None 157963802 Common - diguanylate cyclase Spea_3991 176 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 157961548 Common - metal dependent phosphohydrolase Spea_1724 114 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 157962736 Common - hypothetical protein Spea_2918 2 None None None 157959985 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Spea_0155 42 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 157960935 Common - Fe(II) trafficking protein YggX Spea_1107 72 COG2924 COG2924, Uncharacterized protein conserved in bacteria Function unknown 157962796 Common - multiple antibiotic resistance (MarC)-related protein Spea_2978 158 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 157959996 Common - RNP-1 like RNA-binding protein Spea_0166 66 COG0724 COG0724, RNA-binding proteins (RRM domain) General function prediction only 157962447 Common - protein of unknown function DUF45 Spea_2626 40 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 157963666 Common - D-galactarate dehydratase/Altronate hydrolase domain protein Spea_3855 73 COG2721 UxaA, Altronate dehydratase Carbohydrate transport and metabolism 157963961 Nonpathogen - hypothetical protein Spea_4150 1 None None None 157962402 Common - HAD-superfamily hydrolase, subfamily IIA Spea_2581 98 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 157961734 Common - acetolactate synthase, large subunit, biosynthetic type Spea_1911 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 157963856 Common - magnesium transporter Spea_4045 155 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 157960401 Common - Integrase catalytic region Spea_0572 134 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157960302 Common - hypothetical protein Spea_0473 6 None None None 157960134 Common - diguanylate phosphodiesterase Spea_0305 172 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 157962256 Common - Asparaginase Spea_2435 84 COG1446 COG1446, Asparaginase Amino acid transport and metabolism 157962061 Common - phospholipase D/Transphosphatidylase Spea_2240 145 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 157961553 Common - acriflavin resistance protein Spea_1729 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 157961172 Common - flagellar basal-body rod protein FlgF Spea_1344 122 COG4787 FlgF, Flagellar basal body rod protein Cell motility and secretion 157964016 Common - type I secretion outer membrane protein, TolC family Spea_4205 132 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 157961105 Nonpathogen - hypothetical protein Spea_1277 3 None None None 157960705 Common - histidine kinase Spea_0877 217 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157962406 Common - YfcL protein Spea_2585 17 None None None 157960742 Common - hypothetical protein Spea_0914 6 None None None 157962001 Common - Inorganic diphosphatase Spea_2180 55 COG1227 PPX1, Inorganic pyrophosphatase/exopolyphosphatase Energy production and conversion 157960489 Common - Phospholipase A(1) Spea_0661 50 COG2829 PldA, Outer membrane phospholipase A Cell envelope biogenesis, outer membrane 157961448 Common - Integrase catalytic region Spea_1622 134 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157964002 Common - ABC transporter related Spea_4191 249 COG4555 NatA, ABC-type Na+ transport system, ATPase component Energy production and conversion / Inorganic ion transport and metabolism 157960436 Common - hypothetical protein Spea_0607 2 None None None 157961997 Common - acyl-CoA dehydrogenase domain protein Spea_2176 140 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157962305 Common - ABC transporter related Spea_2484 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 157963508 Common - acriflavin resistance protein Spea_3696 181 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 157960129 Common - Nucleotidyl transferase Spea_0300 236 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 157960393 Common - hypothetical protein Spea_0564 1 None None None 157960069 Common - Sporulation domain protein Spea_0240 4 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 157962377 Nonpathogen - hypothetical protein Spea_2556 3 None None None 157961417 Common - protein of unknown function DUF1538 Spea_1591 23 None None None 157961108 Nonpathogen - hypothetical protein Spea_1280 1 None None None 157961778 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Spea_1955 202 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 157961703 Common - conserved hypothetical ABC transporter protein Spea_1879 12 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 157962992 Common - peptidase S8 and S53 subtilisin kexin sedolisin Spea_3175 48 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 157962876 Common - tRNA pseudouridine synthase B Spea_3058 245 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 157960048 Common - periplasmic protein thiol--disulphide oxidoreductase DsbE Spea_0219 137 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 157962019 Common - transcriptional regulator, AraC family Spea_2198 58 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 157960469 Common - aromatic amino acid permease Spea_0641 32 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 157963784 Common - Mandelate racemase/muconate lactonizing protein Spea_3973 63 COG1441 MenC, O-succinylbenzoate synthase Coenzyme metabolism 157963216 Common - YbaK/prolyl-tRNA synthetase associated region Spea_3402 28 COG2606 EbsC, Uncharacterized conserved protein Function unknown 157963720 Common - putative ribonuclease BN Spea_3909 142 COG1295 Rbn, Predicted membrane protein Function unknown 157960273 Common - formate dehydrogenase family accessory protein FdhD Spea_0444 134 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 157960388 Common - methionine repressor, MetJ Spea_0559 23 COG3060 MetJ, Transcriptional regulator of met regulon Transcription / Amino acid transport and metabolism 157963843 Common - transferase hexapeptide repeat containing protein Spea_4032 192 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 157960164 Common - two component transcriptional regulator, winged helix family Spea_0335 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157963533 Common - MaoC domain protein dehydratase Spea_3721 25 COG2030 MaoC, Acyl dehydratase Lipid metabolism 157962724 Common - 4'-phosphopantetheinyl transferase Spea_2905 37 COG2091 Sfp, Phosphopantetheinyl transferase Coenzyme metabolism 157960235 Common - transposase IS116/IS110/IS902 family protein Spea_0406 98 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 157963360 Common - hypothetical protein Spea_3546 5 None None None 157961197 Common - flagellar motor switch protein FliN Spea_1369 122 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 157959891 Common - flagellar protein FliS Spea_0061 79 COG1516 FliS, Flagellin-specific chaperone FliS Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 157960038 Common - DNA-directed RNA polymerase, alpha subunit Spea_0209 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 157963693 Common - AMP-dependent synthetase and ligase Spea_3882 220 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 157959862 Common - Peptidoglycan-binding LysM Spea_0032 46 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 157960541 Common - TonB-dependent receptor Spea_0713 105 COG4772 FecA, Outer membrane receptor for Fe3+-dicitrate Inorganic ion transport and metabolism 157963330 Common - acetylornithine and succinylornithine aminotransferase Spea_3516 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 157963800 Common - heavy metal efflux pump, CzcA family Spea_3989 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 157962542 Nonpathogen - hypothetical protein Spea_2721 1 None None None 157963203 Common - FAD-dependent pyridine nucleotide-disulfide oxidoreductase Spea_3388 85 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 157959920 Common - flagellar biosynthetic protein FliQ Spea_0090 69 COG1987 FliQ, Flagellar biosynthesis pathway, component FliQ Cell motility and secretion / Intracellular trafficking and secretion 157960317 Common - copper ABC transporter, permease protein Spea_0488 28 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 157963519 Common - Integrase catalytic region Spea_3707 142 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157962566 Common - binding-protein-dependent transport systems inner membrane component Spea_2745 221 COG4590 COG4590, ABC-type uncharacterized transport system, permease component General function prediction only 157960679 Common - Polyprenyl synthetase Spea_0851 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 157963250 Common - hypothetical protein Spea_3436 1 None None None 157961459 Common - hypothetical protein Spea_1633 2 None None None 157962618 Common - acyl-CoA dehydrogenase domain protein Spea_2797 171 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157960029 Common - ribosomal protein L6 Spea_0199 231 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 157962316 Common - malonyl CoA-acyl carrier protein transacylase Spea_2495 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 157960460 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Spea_0631 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 157963209 Nonpathogen - hypothetical protein Spea_3394 1 None None None 157961526 Common - transcriptional regulator, GntR family Spea_1701 133 COG1802 GntR, Transcriptional regulators Transcription 157962075 Common - L-asparaginase, type I Spea_2254 136 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 157960546 Common - hypothetical protein Spea_0718 7 None None None 157962470 Common - Biopolymer transport protein ExbD/TolR Spea_2649 126 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 157962200 Common - thiazole biosynthesis family protein Spea_2379 166 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 157963283 Common - hypothetical protein Spea_3469 17 None None None 157961717 Common - hypothetical protein Spea_1894 4 COG1831 COG1831, Predicted metal-dependent hydrolase (urease superfamily) General function prediction only 157962528 Common - hypothetical protein Spea_2707 2 None None None 157963941 Common - Formate dehydrogenase region TAT target Spea_4130 2 None None None 157962686 Common - sodium/hydrogen exchanger Spea_2867 223 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 157963478 Common - hypothetical protein Spea_3666 21 COG0729 COG0729, Outer membrane protein Cell envelope biogenesis, outer membrane 157961353 Common - Thioredoxin domain Spea_1527 135 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 157960657 Common - two component transcriptional regulator, LuxR family Spea_0829 221 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 157961718 Nonpathogen - hypothetical protein Spea_1895 1 None None None 157962979 Common - hypothetical protein Spea_3162 2 None None None 157960555 Common - inner-membrane translocator Spea_0727 128 COG4603 COG4603, ABC-type uncharacterized transport system, permease component General function prediction only 157960597 Common - transcriptional regulator, MarR family with acetyltransferase activity Spea_0769 56 COG1846 MarR, Transcriptional regulators Transcription 157960281 Nonpathogen - hypothetical protein Spea_0452 2 None None None 157963482 Common - hypothetical protein Spea_3670 9 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 157961749 Common - hydrolase, TatD family Spea_1926 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 157963590 Common - primosomal protein N' Spea_3778 213 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 157960726 Common - Radical SAM domain protein Spea_0898 92 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 157961036 Common - glutamate--cysteine ligase Spea_1208 58 COG2918 GshA, Gamma-glutamylcysteine synthetase Coenzyme metabolism 157963811 Common - Cytochrome c oxidase subunit I type Spea_4000 174 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 157963646 Common - ribosomal protein L33 Spea_3835 134 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 157962949 Nonpathogen - hypothetical protein Spea_3132 1 None None None 157961542 Common - xanthosine phosphorylase Spea_1718 132 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 157961684 Common - methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor Spea_1860 164 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157963307 Common - ABC transporter CydDC cysteine exporter (CydDC-E) family permease/ATP-binding protein CydC Spea_3493 249 COG4987 CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 157960143 Common - Na+/H+ antiporter NhaC Spea_0314 60 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 157961994 Common - short-chain dehydrogenase/reductase SDR Spea_2173 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157960056 Common - N-acetyl-gamma-glutamyl-phosphate reductase Spea_0227 213 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 157963186 Common - hypothetical protein Spea_3371 39 COG3686 COG3686, Predicted membrane protein Function unknown 157959983 Common - General secretion pathway M protein Spea_0153 21 COG3149 PulM, Type II secretory pathway, component PulM Intracellular trafficking and secretion 157963090 Nonpathogen - hypothetical protein Spea_3274 7 None None None 157962922 Common - BolA family protein Spea_3105 104 COG0271 BolA, Stress-induced morphogen (activity unknown) Signal transduction mechanisms 157962184 Common - Holliday junction DNA helicase RuvA Spea_2363 211 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 157961149 Nonpathogen - hypothetical protein Spea_1321 1 None None None 157963266 Common - ATPase-like protein Spea_3452 80 COG1485 COG1485, Predicted ATPase General function prediction only 157960186 Common - acriflavin resistance protein Spea_0357 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 157961199 Common - flagellar biosynthetic protein FliP Spea_1371 128 COG1338 FliP, Flagellar biosynthesis pathway, component FliP Cell motility and secretion / Intracellular trafficking and secretion 157963159 Common - trimethylamine-N-oxide reductase TorA Spea_3343 160 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 157963385 Common - transcriptional regulator, LysR family Spea_3571 33 COG0583 LysR, Transcriptional regulator Transcription 157961829 Common - Peptidoglycan-binding domain 1 protein Spea_2008 74 COG2989 COG2989, Uncharacterized protein conserved in bacteria Function unknown 157963352 Common - HflK protein Spea_3538 200 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 157963657 Common - HipA domain protein Spea_3846 67 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 157960183 Common - phosphoesterase PA-phosphatase related Spea_0354 27 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 157960275 Common - SirA family protein Spea_0446 34 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 157960972 Common - Alkaline phosphatase Spea_1144 84 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 157961309 Common - phosphate-starvation-inducible E Spea_1483 14 COG3223 COG3223, Predicted membrane protein Function unknown 157963480 Common - protein of unknown function DUF1255 Spea_3668 51 COG3123 COG3123, Uncharacterized protein conserved in bacteria Function unknown 157963067 Common - CG2839 Spea_3250 14 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 157960970 Common - Threonine aldolase Spea_1142 111 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 157961047 Common - OsmC family protein Spea_1219 41 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 157962556 Common - alpha/beta hydrolase fold Spea_2735 155 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 157962153 Common - 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase Spea_2332 126 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 157960483 Common - phosphoadenosine phosphosulfate reductase Spea_0655 151 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 157961575 Common - Phasin family protein Spea_1751 7 None None None 157961631 Common - molybdopterin oxidoreductase Spea_1807 188 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 157960626 Common - transposase Spea_0798 9 None None None 157962903 Common - glutamate 5-kinase Spea_3085 189 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 157962356 Common - isocitrate dehydrogenase, NADP-dependent Spea_2535 65 COG2838 Icd, Monomeric isocitrate dehydrogenase Energy production and conversion 157962705 Common - methionine aminopeptidase, type I Spea_2886 247 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 157962764 Common - NUDIX hydrolase Spea_2946 14 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 157963711 Common - Beta-ketoacyl synthase Spea_3900 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 157963604 Common - ubiquinone/menaquinone biosynthesis methyltransferase Spea_3792 221 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 157960244 Common - nicotinate-nucleotide pyrophosphorylase Spea_0415 205 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 157960122 Nonpathogen - hypothetical protein Spea_0293 5 None None None 157960093 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Spea_0264 181 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 157962634 Common - Endoribonuclease L-PSP Spea_2814 81 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 157963559 Common - peptidase U62 modulator of DNA gyrase Spea_3747 170 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 157960352 Common - hypothetical protein Spea_0523 6 None None None 157962881 Common - preprotein translocase, SecG subunit Spea_3063 69 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 157963487 Common - glycine cleavage system regulatory protein-like protein Spea_3675 12 COG2716 GcvR, Glycine cleavage system regulatory protein Amino acid transport and metabolism 157961231 Common - hypothetical protein Spea_1404 20 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 157962838 Common - peptidase U32 Spea_3020 47 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 157963451 Common - protein of unknown function DUF134 Spea_3639 37 COG1342 COG1342, Predicted DNA-binding proteins General function prediction only 157962753 Common - two component transcriptional regulator, winged helix family Spea_2935 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157961466 Common - intracellular septation protein A Spea_1640 92 COG2917 COG2917, Intracellular septation protein A Cell division and chromosome partitioning 157960878 Common - 16S rRNA processing protein RimM Spea_1050 186 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 157960661 Common - nitrogen regulatory protein P-II Spea_0833 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 157963415 Common - response regulator receiver protein Spea_3601 202 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 157959960 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Spea_0130 188 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 157963951 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Spea_4140 69 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 157963405 Common - Sel1 domain protein repeat-containing protein Spea_3591 22 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 157963202 Common - S-(hydroxymethyl)glutathione synthase Spea_3387 16 COG3791 COG3791, Uncharacterized conserved protein Function unknown 157963660 Common - hypothetical protein Spea_3849 8 None None None 157963489 Nonpathogen - hypothetical protein Spea_3677 2 None None None 157962143 Common - methylisocitrate lyase Spea_2322 133 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 157962160 Common - transcriptional regulator, TetR family Spea_2339 79 COG1309 AcrR, Transcriptional regulator Transcription 157960646 Common - Endonuclease/exonuclease/phosphatase Spea_0818 13 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 157960656 Common - hypothetical protein Spea_0828 22 COG3112 COG3112, Uncharacterized protein conserved in bacteria Function unknown 157960927 Common - SapC family protein Spea_1099 25 None None None 157963920 Common - histidine kinase Spea_4109 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157962851 Common - type IV pilus assembly PilZ Spea_3033 7 None None None 157963890 Common - putative endoribonuclease L-PSP Spea_4079 185 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 157963410 Common - AFG1-family ATPase Spea_3596 104 COG1485 COG1485, Predicted ATPase General function prediction only 157962196 Common - histidine kinase Spea_2375 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157961913 Common - porin Gram-negative type Spea_2092 26 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 157960650 Common - hypothetical protein Spea_0822 1 None None None 157963899 Common - TonB-dependent receptor Spea_4088 123 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 157961118 Common - malate synthase A Spea_1290 69 COG2225 AceB, Malate synthase Energy production and conversion 157963566 Common - cell shape determining protein, MreB/Mrl family Spea_3754 234 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 157960895 Common - homoserine kinase Spea_1067 118 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 157961328 Common - hypothetical protein Spea_1502 1 COG3767 COG3767, Uncharacterized low-complexity protein Function unknown 157962884 Common - dihydropteroate synthase Spea_3066 218 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 157960820 Common - putative two component transcriptional regulator, winged helix family Spea_0992 76 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157963357 Common - N-acetylmuramoyl-L-alanine amidase Spea_3543 179 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 157962596 Common - hypothetical protein Spea_2775 1 None None None 157962105 Common - ABC transporter related Spea_2284 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 157960022 Common - ribosomal protein L29 Spea_0192 142 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 157961225 Common - dTDP-glucose 4,6-dehydratase Spea_1398 230 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 157962786 Common - PAS/PAC sensor signal transduction histidine kinase Spea_2968 220 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 157960983 Common - acriflavin resistance protein Spea_1155 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 157963764 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Spea_3953 182 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 157963667 Common - D-galactarate dehydratase Spea_3856 24 None None None 157961988 Common - protein of unknown function DUF1329 Spea_2167 17 None None None 157960341 Common - ABC-2 type transporter Spea_0512 46 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 157963550 Common - transcriptional regulator, ArsR family Spea_3738 146 COG0640 ArsR, Predicted transcriptional regulators Transcription 157960225 Common - transcriptional regulator, LysR family Spea_0396 171 COG0583 LysR, Transcriptional regulator Transcription 157963059 Common - hypothetical protein Spea_3242 6 None None None 157960437 Common - UDP-galactopyranose mutase Spea_0608 60 COG0562 Glf, UDP-galactopyranose mutase Cell envelope biogenesis, outer membrane 157962068 Common - Succinylglutamate desuccinylase/aspartoacylase Spea_2247 24 COG2988 COG2988, Succinylglutamate desuccinylase Amino acid transport and metabolism 157962934 Common - sodium:neurotransmitter symporter Spea_3117 88 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 157963818 Common - electron transport protein SCO1/SenC Spea_4007 107 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 157961315 Common - FeS cluster assembly scaffold IscU Spea_1489 156 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 157962916 Common - NADH:ubiquinone oxidoreductase, subunit E Spea_3099 76 COG2209 NqrE, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE Energy production and conversion 157962818 Common - MATE efflux family protein Spea_3000 161 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 157961011 Common - MazG family protein Spea_1183 156 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 157962144 Common - transcriptional regulator, GntR family Spea_2323 140 COG1802 GntR, Transcriptional regulators Transcription 157960880 Common - ribosomal protein L19 Spea_1052 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 157964036 Common - naphthoate synthase Spea_4225 175 COG0447 MenB, Dihydroxynaphthoic acid synthase Coenzyme metabolism 157962137 Common - putative orphan protein Spea_2316 5 None None None 157961921 Common - short-chain dehydrogenase/reductase SDR Spea_2100 222 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157961124 Common - hypothetical protein Spea_1296 42 COG3530 COG3530, Uncharacterized protein conserved in bacteria Function unknown 157962593 Common - copper-translocating P-type ATPase Spea_2772 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 157962302 Common - hypothetical protein Spea_2481 44 COG2996 COG2996, Uncharacterized protein conserved in bacteria Function unknown 157961624 Common - adenosylmethionine-8-amino-7-oxononanoate aminotransferase Spea_1800 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 157963137 Common - Cytochrome c oxidase cbb3 type accessory protein FixG Spea_3321 80 COG0348 NapH, Polyferredoxin Energy production and conversion 157959856 Common - Protoporphyrinogen oxidase Spea_0026 35 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 157960571 Common - dienelactone hydrolase Spea_0743 37 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 157961670 Common - hypothetical protein Spea_1846 17 COG4929 COG4929, Uncharacterized membrane-anchored protein Function unknown 157961133 Common - 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase Spea_1305 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 157961174 Common - flagellar L-ring protein Spea_1346 101 COG2063 FlgH, Flagellar basal body L-ring protein Cell motility and secretion 157961513 Common - cell division protein ZipA Spea_1688 42 COG3115 ZipA, Cell division protein Cell division and chromosome partitioning 157963045 Common - HAD-superfamily hydrolase, subfamily IB (PSPase-like) Spea_3228 23 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 157961663 Common - membrane-fusion protein Spea_1839 139 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157962170 Common - exsB protein Spea_2349 176 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 157962855 Common - Polysulphide reductase NrfD Spea_3037 41 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 157961534 Nonpathogen - hypothetical protein Spea_1709 2 None None None 157963312 Common - DEAD/DEAH box helicase domain protein Spea_3498 237 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 157960060 Common - argininosuccinate lyase Spea_0231 229 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 157961677 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Spea_1853 112 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 157960179 Common - Serine--pyruvate transaminase Spea_0350 155 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 157962966 Common - Peptidoglycan glycosyltransferase Spea_3149 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 157960859 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Spea_1031 174 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 157963903 Common - histidine kinase Spea_4092 217 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 157961508 Common - RDD domain containing protein Spea_1683 2 COG1714 COG1714, Predicted membrane protein/domain Function unknown 157961110 Common - SsrA-binding protein Spea_1282 208 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 157960474 Common - rfaE bifunctional protein Spea_0646 187 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 157961291 Common - oxidoreductase domain protein Spea_1465 137 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 157961793 Common - arsenate reductase Spea_1970 114 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 157961281 Common - hypothetical protein Spea_1455 2 None None None 157963783 Common - alpha/beta hydrolase fold Spea_3972 147 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 157962699 Common - phosphatidate cytidylyltransferase Spea_2880 215 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 157964039 Common - phosphate binding protein Spea_4228 132 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 157962367 Common - transcriptional regulator, MarR family Spea_2546 138 COG1846 MarR, Transcriptional regulators Transcription 157959941 Common - glycosyl transferase family 9 Spea_0111 108 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 157960862 Common - positive regulator of sigma E, RseC/MucC Spea_1034 37 COG3086 RseC, Positive regulator of sigma E activity Signal transduction mechanisms 157962954 Common - tRNA-i(6)A37 thiotransferase enzyme MiaB Spea_3137 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 157960807 Common - cytochrome c class I Spea_0979 50 COG2863 COG2863, Cytochrome c553 Energy production and conversion 157960830 Common - diguanylate cyclase Spea_1002 179 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157961162 Common - protein of unknown function DUF400 Spea_1334 15 COG3018 COG3018, Uncharacterized protein conserved in bacteria Function unknown 157961676 Common - acyl-CoA dehydrogenase domain protein Spea_1852 149 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157960106 Common - protein of unknown function DUF1212 Spea_0277 32 COG2966 COG2966, Uncharacterized conserved protein Function unknown 157963247 Common - 3'-5' exonuclease Spea_3433 19 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 157962683 Common - prolyl-tRNA synthetase Spea_2864 247 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 157959975 Common - general secretory pathway protein E Spea_0145 215 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 157959980 Common - general secretion pathway protein J Spea_0150 28 COG4795 PulJ, Type II secretory pathway, component PulJ Intracellular trafficking and secretion 157963588 Common - ribosomal protein L31 Spea_3776 203 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 157960952 Common - protein of unknown function DUF167 Spea_1124 78 COG1872 COG1872, Uncharacterized conserved protein Function unknown 157962321 Common - maf protein Spea_2500 188 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 157961782 Common - ribosomal protein L25 Spea_1959 129 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 157963240 Common - hypothetical protein Spea_3426 2 None None None 157960320 Nonpathogen - hypothetical protein Spea_0491 4 None None None 157962207 Common - DTW domain containing protein Spea_2386 29 COG3148 COG3148, Uncharacterized conserved protein Function unknown 157961581 Common - Lysine exporter protein (LYSE/YGGA) Spea_1757 98 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 157963581 Common - hypothetical protein Spea_3769 2 None None None 157960278 Common - hypothetical protein Spea_0449 5 None None None 157960788 Common - GatB/YqeY domain protein Spea_0960 153 COG1610 COG1610, Uncharacterized conserved protein Function unknown 157961018 Common - stationary-phase survival protein SurE Spea_1190 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 157962523 Common - hypothetical protein Spea_2702 59 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 157963790 Common - cell division ATP-binding protein FtsE Spea_3979 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 157961789 Common - hypothetical protein Spea_1966 20 COG3249 COG3249, Uncharacterized protein conserved in bacteria Function unknown 157962029 Common - GCN5-related N-acetyltransferase Spea_2208 19 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 157962580 Common - Leucyl aminopeptidase Spea_2759 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 157962640 Common - cytochrome C family protein Spea_2820 40 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 157960073 Common - Ribulose-phosphate 3-epimerase Spea_0244 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 157962658 Common - protein of unknown function DUF1568 Spea_2838 16 None None None 157960572 Common - hypothetical protein Spea_0744 7 None None None 157963275 Nonpathogen - hypothetical protein Spea_3461 1 None None None 157962491 Common - transcriptional regulator, Fis family Spea_2670 168 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 157961005 Common - Hpt sensor hybrid histidine kinase Spea_1177 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157961186 Common - PAS/PAC sensor signal transduction histidine kinase Spea_1358 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157962286 Common - transposase Spea_2465 9 None None None 157960772 Common - peptidase C26 Spea_0944 118 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 157963054 Common - hypothetical protein Spea_3237 28 None None None 157961488 Common - domain of unknown function DUF1731 Spea_1663 107 COG1090 COG1090, Predicted nucleoside-diphosphate sugar epimerase General function prediction only 157960848 Common - DNA mismatch repair endonuclease mutH Spea_1020 29 COG3066 MutH, DNA mismatch repair protein DNA replication, recombination, and repair 157962414 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Spea_2593 194 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 157960798 Common - major outer membrane lipoprotein, putative Spea_0970 6 COG4238 COG4238, Murein lipoprotein Cell envelope biogenesis, outer membrane 157959840 Common - amidohydrolase Spea_0010 164 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 157960585 Common - lysyl-tRNA synthetase Spea_0757 249 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 157963832 Common - hypothetical protein Spea_4021 3 None None None 157960568 Common - Methyltransferase type 12 Spea_0740 50 COG0500 SmtA, SAM-dependent methyltransferases Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157960441 Common - hypothetical protein Spea_0612 14 COG3121 FimC, P pilus assembly protein, chaperone PapD Cell motility and secretion / Intracellular trafficking and secretion 157963994 Common - thioesterase superfamily protein Spea_4183 59 COG0824 FcbC, Predicted thioesterase General function prediction only 157960425 Common - protein of unknown function DUF342 Spea_0596 37 COG1315 COG1315, Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain DNA replication, recombination, and repair 157962454 Common - SMC domain protein Spea_2633 105 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 157963739 Common - hypothetical protein Spea_3928 16 None None None 157961421 Common - regulatory protein RecX Spea_1595 11 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 157960693 Common - Organic solvent tolerance protein Spea_0865 127 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 157960863 Common - GTP-binding protein LepA Spea_1035 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 157961641 Common - transcriptional regulator, LuxR family Spea_1817 141 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 157959880 Common - sialic acid biosynthesis protein NeuD Spea_0050 129 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 157960732 Common - transcriptional regulator, LysR family Spea_0904 154 COG0583 LysR, Transcriptional regulator Transcription 157960715 Common - NADPH-dependent FMN reductase Spea_0887 11 COG0431 COG0431, Predicted flavoprotein General function prediction only 157960905 Common - amino acid carrier protein Spea_1077 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 157962741 Nonpathogen - hypothetical protein Spea_2923 1 None None None 157963181 Common - porin Gram-negative type Spea_3366 24 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 157962127 Common - phosphoadenosine phosphosulfate reductase Spea_2306 43 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 157961984 Common - Amidase Spea_2163 220 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 157963458 Common - protein of unknown function DUF1275 Spea_3646 28 COG3619 COG3619, Predicted membrane protein Function unknown 157960290 Common - hypothetical protein Spea_0461 14 COG3248 Tsx, Nucleoside-binding outer membrane protein Cell envelope biogenesis, outer membrane 157963140 Common - lipid A ABC exporter family, fused ATPase and inner membrane subunits Spea_3324 248 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 157961202 Common - flagellar biosynthetic protein FlhB Spea_1374 130 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 157961039 Common - phosphoribosylaminoimidazole carboxylase, catalytic subunit Spea_1211 230 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 157960297 Common - DNA helicase II Spea_0468 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 157962641 Common - isoprenylcysteine carboxyl methyltransferase family protein Spea_2821 39 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 157962829 Common - peptidase U32 Spea_3011 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 157961267 Common - ROK family protein Spea_1441 132 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 157960406 Common - galactokinase Spea_0577 89 COG0153 GalK, Galactokinase Carbohydrate transport and metabolism 157960156 Common - branched-chain amino acid aminotransferase Spea_0327 197 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 157960594 Common - Fe-S metabolism associated SufE Spea_0766 94 COG2166 COG2166, SufE protein probably involved in Fe-S center assembly General function prediction only 157960747 Common - DEAD/DEAH box helicase domain protein Spea_0919 240 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 157963060 Common - Guanine deaminase Spea_3243 146 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 157961926 Common - hypothetical protein Spea_2105 7 None None None 157961393 Common - lipoprotein, putative Spea_1567 1 None None None 157960670 Common - Phosphoglycerate mutase Spea_0842 9 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 157960850 Common - PTSINtr with GAF domain, PtsP Spea_1022 235 COG3605 PtsP, Signal transduction protein containing GAF and PtsI domains Signal transduction mechanisms 157962942 Common - modification methylase, HemK family Spea_3125 222 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 157962967 Common - rod shape-determining protein RodA Spea_3150 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 157963466 Common - aminotransferase class I and II Spea_3654 240 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 157961257 Nonpathogen - putative anti-sigma regulatory factor, serine/threonine protein kinase Spea_1431 1 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 157960194 Common - type I secretion outer membrane protein, TolC family Spea_0365 124 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 157962505 Common - cysteinyl-tRNA synthetase Spea_2684 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 157963701 Common - hypothetical protein Spea_3890 26 COG4648 COG4648, Predicted membrane protein Function unknown 157960455 Common - protein of unknown function DUF214 Spea_0626 44 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 157961159 Common - fatty acid hydroxylase Spea_1331 73 COG3000 ERG3, Sterol desaturase Lipid metabolism 157963654 Common - orotate phosphoribosyltransferase Spea_3843 121 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 157962929 Common - hypothetical protein Spea_3112 4 None None None 157960431 Common - protein of unknown function DUF335 SprT Spea_0602 26 COG3091 SprT, Uncharacterized protein conserved in bacteria Function unknown 157963268 Nonpathogen - cell death peptidase, inhibitor of T4 late gene expression Spea_3454 3 None None None 157963793 Common - protein of unknown function DUF1145 Spea_3982 9 COG3776 COG3776, Predicted membrane protein Function unknown 157964041 Common - phosphate ABC transporter, inner membrane subunit PstA Spea_4230 231 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 157961201 Common - flagellar biosynthetic protein FliR Spea_1373 126 COG1684 FliR, Flagellar biosynthesis pathway, component FliR Cell motility and secretion / Intracellular trafficking and secretion 157962015 Common - RND efflux system, outer membrane lipoprotein, NodT family Spea_2194 115 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 157961912 Common - FMN-binding domain protein Spea_2091 8 COG3976 COG3976, Uncharacterized protein conserved in bacteria Function unknown 157960910 Common - riboflavin biosynthesis protein RibF Spea_1082 211 COG0196 RibF, FAD synthase Coenzyme metabolism 157963040 Common - diguanylate cyclase Spea_3223 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157963992 Common - hypothetical protein Spea_4181 1 None None None 157962289 Common - integration host factor, alpha subunit Spea_2468 209 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 157962051 Common - CrcB protein Spea_2230 189 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 157963387 Common - decaheme cytochrome c Spea_3573 8 None None None 157963460 Common - aminotransferase class V Spea_3648 191 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 157963467 Common - glycoside hydrolase family 18 Spea_3655 35 COG3469 COG3469, Chitinase Carbohydrate transport and metabolism 157962128 Common - SMC domain protein Spea_2307 47 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 157960639 Nonpathogen - hypothetical protein Spea_0811 1 None None None 157960021 Common - ribosomal protein L16 Spea_0191 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 157960487 Common - protein of unknown function RIO1 Spea_0659 66 COG1718 RIO1, Serine/threonine protein kinase involved in cell cycle control Signal transduction mechanisms / Cell division and chromosome partitioning 157961949 Common - glycosyl hydrolase, BNR repeat Spea_2128 37 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 157962560 Common - protein of unknown function DUF1289 Spea_2739 20 COG3313 COG3313, Predicted Fe-S protein General function prediction only 157963078 Common - cold-shock DNA-binding domain protein Spea_3261 182 COG1278 CspC, Cold shock proteins Transcription 157961790 Common - Chromosomal replication initiator DnaA Spea_1967 187 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 157960933 Common - transposase Spea_1105 9 None None None 157960591 Common - cupin family protein Spea_0763 34 None None None 157961625 Common - biotin synthase Spea_1801 178 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 157960180 Common - TonB-dependent copper receptor Spea_0351 102 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 157962670 Common - Thymidine kinase Spea_2851 97 COG1435 Tdk, Thymidine kinase Nucleotide transport and metabolism 157962990 Common - hypothetical protein Spea_3173 23 COG3595 COG3595, Uncharacterized conserved protein Function unknown 157963132 Common - methylation site containing protein Spea_3316 4 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 157962254 Common - Xanthine phosphoribosyltransferase Spea_2433 69 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 157963265 Common - transcriptional regulator, LysR family Spea_3451 171 COG0583 LysR, Transcriptional regulator Transcription 157960346 Common - Monosaccharide-transporting ATPase Spea_0517 131 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 157961823 Common - GreA/GreB family elongation factor Spea_2002 13 COG0782 GreA, Transcription elongation factor Transcription 157963598 Common - cyclic nucleotide-binding protein Spea_3786 5 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 157960740 Common - permease YjgP/YjgQ family protein Spea_0912 120 COG0795 COG0795, Predicted permeases General function prediction only 157964030 Common - carboxyl-terminal protease Spea_4219 181 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 157959978 Common - general secretion pathway protein H Spea_0148 9 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 157960855 Common - transcriptional regulator, LysR family Spea_1027 92 COG0583 LysR, Transcriptional regulator Transcription 157963702 Common - hypothetical protein Spea_3891 125 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 157960981 Nonpathogen - hypothetical protein Spea_1153 1 None None None 157962827 Common - diguanylate cyclase/phosphodiesterase Spea_3009 167 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 157961786 Common - Superoxide dismutase Spea_1963 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 157960295 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Spea_0466 180 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 157962567 Common - amino acid-binding ACT domain protein Spea_2746 22 COG2716 GcvR, Glycine cleavage system regulatory protein Amino acid transport and metabolism 157960047 Common - cytochrome c-type biogenesis protein CcmF Spea_0218 135 COG1138 CcmF, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 157961000 Common - Pirin domain protein Spea_1172 142 COG1741 COG1741, Pirin-related protein General function prediction only 157960621 Common - putative transcriptional regulator, CadC Spea_0793 1 COG3710 CadC, DNA-binding winged-HTH domains Transcription 157962587 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Spea_2766 15 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 157962698 Common - 1-deoxy-D-xylulose 5-phosphate reductoisomerase Spea_2879 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 157963111 Common - protein of unknown function DUF1568 Spea_3295 54 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 157960866 Common - GTP-binding protein Era Spea_1038 223 COG1159 Era, GTPase General function prediction only 157960632 Common - branched-chain amino acid transport system II carrier protein Spea_0804 50 COG1114 BrnQ, Branched-chain amino acid permeases Amino acid transport and metabolism 157961967 Common - NADH:flavin oxidoreductase/NADH oxidase Spea_2146 212 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 157963190 Nonpathogen - hypothetical protein Spea_3375 1 None None None 157962642 Common - protein of unknown function DUF1176 Spea_2822 11 COG3755 COG3755, Uncharacterized protein conserved in bacteria Function unknown 157962945 Common - outer membrane lipoprotein LolB Spea_3128 51 COG3017 LolB, Outer membrane lipoprotein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 157961493 Common - phosphate acetyltransferase Spea_1668 173 COG0280 Pta, Phosphotransacetylase Energy production and conversion 157962222 Common - hypothetical protein Spea_2401 11 None None None 157961440 Common - Integrase catalytic region Spea_1614 142 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157962654 Nonpathogen - hypothetical protein Spea_2834 1 None None None 157960471 Nonpathogen - hypothetical protein Spea_0643 1 None None None 157960532 Common - ATP-dependent helicase HrpB Spea_0704 135 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 157961972 Common - nonspecific lipid-transfer protein Spea_2151 90 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 157961325 Common - TonB-dependent receptor Spea_1499 110 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 157961622 Common - hypothetical protein Spea_1798 3 None None None 157960408 Nonpathogen - beta-galactosidase Spea_0579 2 None None None 157960530 Nonpathogen - hypothetical protein Spea_0702 2 None None None 157963999 Common - ABC transporter related Spea_4188 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 157963003 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) Spea_3186 201 COG0281 SfcA, Malic enzyme Energy production and conversion 157960791 Common - 2OG-Fe(II) oxygenase Spea_0963 30 COG3751 EGL-9, Predicted proline hydroxylase Posttranslational modification, protein turnover, chaperones 157963104 Common - hypothetical protein Spea_3288 5 None None None 157962368 Common - hypothetical protein Spea_2547 17 COG3816 COG3816, Uncharacterized protein conserved in bacteria Function unknown 157960163 Common - histidine kinase Spea_0334 103 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157960191 Common - diguanylate cyclase/phosphodiesterase Spea_0362 143 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 157963623 Common - cell division protein FtsW Spea_3812 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 157960876 Common - signal recognition particle protein Spea_1048 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 157963229 Common - hypothetical protein Spea_3415 3 None None None 157960806 Common - uncharacterized FlgJ-related protein-like protein Spea_0978 31 COG2992 Bax, Uncharacterized FlgJ-related protein General function prediction only 157962282 Common - phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Spea_2461 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 157963591 Common - arginyl-tRNA synthetase Spea_3779 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 157960187 Common - efflux transporter, RND family, MFP subunit Spea_0358 171 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157961516 Common - metal dependent phosphohydrolase Spea_1691 120 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 157961115 Common - hypothetical protein Spea_1287 1 None None None 157961191 Common - flagellar assembly protein FliH Spea_1363 46 COG1317 FliH, Flagellar biosynthesis/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 157962590 Common - transcriptional regulator, AraC family Spea_2769 54 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 157963134 Common - Lysine exporter protein (LYSE/YGGA) Spea_3318 102 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 157961027 Common - oxaloacetate decarboxylase alpha subunit Spea_1199 208 COG5016 COG5016, Pyruvate/oxaloacetate carboxyltransferase Energy production and conversion 157963651 Common - transcriptional regulator, TetR family Spea_3840 61 COG1309 AcrR, Transcriptional regulator Transcription 157963149 Common - ABC transporter related Spea_3333 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 157960988 Common - Glycine hydroxymethyltransferase Spea_1160 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 157963158 Common - trimethylamine-N-oxide reductase c-type cytochrome TorC Spea_3342 49 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 157962023 Nonpathogen - hypothetical protein Spea_2202 1 None None None 157960327 Nonpathogen - hypothetical protein Spea_0498 1 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 157961848 Common - hydrogenase accessory protein HypB Spea_2027 126 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 157961507 Common - cysteine synthase A Spea_1682 219 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 157961383 Common - Ion transport protein Spea_1557 94 COG1226 Kch, Kef-type K+ transport systems, predicted NAD-binding component Inorganic ion transport and metabolism 157962334 Common - hypothetical protein Spea_2513 3 None None None 157960586 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Spea_0758 193 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 157961379 Common - hypothetical protein Spea_1553 3 None None None 157963441 Common - glycosyl transferase family 2 Spea_3629 184 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 157960628 Common - acriflavin resistance protein Spea_0800 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 157960647 Common - MORN variant repeat protein Spea_0819 18 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 157961954 Common - Electron transfer flavoprotein alpha/beta-subunit Spea_2133 153 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 157962844 Common - Xanthine/uracil/vitamin C permease Spea_3026 134 COG2252 COG2252, Permeases General function prediction only 157960781 Common - UspA domain protein Spea_0953 88 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 157961485 Common - Arylesterase Spea_1660 100 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 157961208 Common - chemotaxis phosphatase, CheZ Spea_1380 46 COG3143 CheZ, Chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157961433 Nonpathogen - hypothetical protein Spea_1607 3 None None None 157963602 Common - Ribonuclease E inhibitor RraA Spea_3790 90 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 157962497 Common - Trans-2-enoyl-CoA reductase (NAD(+)) Spea_2676 25 COG3007 COG3007, Uncharacterized paraquat-inducible protein B Function unknown 157961497 Common - formate acetyltransferase Spea_1672 59 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 157961014 Common - Septum formation initiator Spea_1186 63 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 157962813 Common - FAD linked oxidase domain protein Spea_2995 198 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 157963780 Common - transcriptional regulator, LysR family Spea_3969 47 COG0583 LysR, Transcriptional regulator Transcription 157961600 Common - sigma54 specific transcriptional regulator, Fis family Spea_1776 169 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 157962627 Common - transporter, hydrophobe/amphiphile efflux-1 (HAE1) family Spea_2807 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 157960921 Common - type IV pilus biogenesis protein, putative Spea_1093 38 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 157961504 Common - C4-dicarboxylate transporter/malic acid transport protein Spea_1679 40 COG1275 TehA, Tellurite resistance protein and related permeases Inorganic ion transport and metabolism 157962754 Common - histidine kinase Spea_2936 211 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157959877 Common - DegT/DnrJ/EryC1/StrS aminotransferase Spea_0047 191 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 157960816 Common - MIP family channel protein Spea_0988 126 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 157961398 Common - protein of unknown function DUF107 Spea_1572 60 COG1030 NfeD, Membrane-bound serine protease (ClpP class) Posttranslational modification, protein turnover, chaperones 157963718 Common - hypothetical protein Spea_3907 2 None None None 157959859 Common - sun protein Spea_0029 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 157963151 Common - bifunctional deaminase-reductase domain protein Spea_3335 69 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 157960172 Common - transcriptional regulator, LysR family Spea_0343 180 COG0583 LysR, Transcriptional regulator Transcription 157961370 Common - hypothetical protein Spea_1544 7 None None None 157960951 Common - hypothetical protein Spea_1123 13 None None None 157963577 Common - type II secretion system protein E Spea_3765 223 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 157961773 Common - ribosome modulation factor Spea_1950 21 COG3130 Rmf, Ribosome modulation factor Translation, ribosomal structure and biogenesis 157959973 Common - general secretion pathway protein C Spea_0143 33 COG3031 PulC, Type II secretory pathway, component PulC Intracellular trafficking and secretion 157961895 Common - integration host factor, beta subunit Spea_2074 207 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 157961038 Common - hypothetical protein Spea_1210 38 COG4764 COG4764, Uncharacterized protein conserved in bacteria Function unknown 157960523 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Spea_0695 187 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 157962360 Common - protein of unknown function DUF489 Spea_2539 41 COG2915 COG2915, Uncharacterized protein involved in purine metabolism General function prediction only 157961681 Common - Peptidyl-dipeptidase Dcp Spea_1857 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 157963705 Common - Histidine ammonia-lyase Spea_3894 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 157962329 Common - GTP-binding protein HSR1-related Spea_2508 97 COG1161 COG1161, Predicted GTPases General function prediction only 157962086 Common - short-chain dehydrogenase/reductase SDR Spea_2265 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157962193 Common - alpha-L-glutamate ligase-like protein Spea_2372 18 None None None 157960653 Common - Tetratricopeptide TPR_2 repeat protein Spea_0825 28 COG3014 COG3014, Uncharacterized protein conserved in bacteria Function unknown 157960298 Common - 4-hydroxybenzoate polyprenyl transferase Spea_0469 198 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 157962982 Common - protein of unknown function DUF152 Spea_3165 181 COG1496 COG1496, Uncharacterized conserved protein Function unknown 157963620 Common - Polypeptide-transport-associated domain protein FtsQ-type Spea_3809 80 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 157960770 Common - FAD dependent oxidoreductase Spea_0942 111 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 157961292 Common - hypothetical protein Spea_1466 1 None None None 157963227 Common - hypothetical protein Spea_3413 2 None None None 157962100 Common - major facilitator superfamily MFS_1 Spea_2279 88 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 157963356 Common - DNA mismatch repair protein MutL Spea_3542 191 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 157963648 Common - DNA repair protein RadC Spea_3837 178 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 157961396 Common - sodium:dicarboxylate symporter Spea_1570 163 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 157960926 Common - tryptophan halogenase Spea_1098 16 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 157959924 Common - alpha/beta hydrolase fold Spea_0094 91 COG2267 PldB, Lysophospholipase Lipid metabolism 157963485 Nonpathogen - hypothetical protein Spea_3673 1 None None None 157960573 Common - spermine synthase Spea_0745 28 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 157960132 Common - hypothetical protein Spea_0303 22 None None None 157960265 Common - putative thiol-disulphide oxidoreductase DCC Spea_0436 31 COG3011 COG3011, Uncharacterized protein conserved in bacteria Function unknown 157962667 Common - LemA family protein Spea_2848 127 COG1704 LemA, Uncharacterized conserved protein Function unknown 157962063 Common - methyl-accepting chemotaxis sensory transducer Spea_2242 154 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157960312 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Spea_0483 163 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 157961839 Common - Flp pilus assembly protein ATPase CpaE-like protein Spea_2018 64 COG4963 CpaE, Flp pilus assembly protein, ATPase CpaE Intracellular trafficking and secretion 157962096 Nonpathogen - hypothetical protein Spea_2275 3 None None None 157963763 Common - hypothetical protein Spea_3952 1 None None None 157960727 Common - hypothetical protein Spea_0899 4 None None None 157963866 Common - hypothetical protein Spea_4055 10 None None None 157961031 Common - extracellular solute-binding protein family 1 Spea_1203 133 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 157963956 Common - hypothetical protein Spea_4145 16 COG4994 COG4994, Uncharacterized protein conserved in bacteria Function unknown 157961669 Common - hypothetical protein Spea_1845 6 COG4984 COG4984, Predicted membrane protein Function unknown 157963469 Common - hypothetical protein Spea_3657 2 None None None 157961303 Common - YaeQ family protein Spea_1477 52 COG4681 COG4681, Uncharacterized protein conserved in bacteria Function unknown 157960714 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Spea_0886 13 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 157962935 Common - phosphoesterase PA-phosphatase related Spea_3118 12 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 157962150 Common - proteinase inhibitor I11 ecotin Spea_2329 23 COG4574 Eco, Serine protease inhibitor ecotin General function prediction only 157963725 Common - Disulphide bond formation protein DsbB Spea_3914 17 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 157960434 Common - Carbamoyl-phosphate synthase L chain ATP-binding Spea_0605 233 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 157961255 Common - polysaccharide export protein Spea_1429 18 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 157961806 Common - acriflavin resistance protein Spea_1983 178 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 157962704 Common - ribosomal protein S2 Spea_2885 224 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 157960098 Common - Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase Spea_0269 200 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 157960196 Common - ABC transporter related Spea_0367 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 157961765 Common - NAD-glutamate dehydrogenase Spea_1942 77 COG2902 COG2902, NAD-specific glutamate dehydrogenase Amino acid transport and metabolism 157961911 Common - ApbE family lipoprotein Spea_2090 122 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 157960640 Common - NUDIX hydrolase Spea_0812 39 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 157960465 Common - thioesterase superfamily protein Spea_0636 96 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 157963807 Common - Glycerol-3-phosphate O-acyltransferase Spea_3996 48 COG2937 PlsB, Glycerol-3-phosphate O-acyltransferase Lipid metabolism 157960421 Common - hypothetical protein Spea_0592 2 None None None 157959900 Common - flagellar basal-body rod protein FlgG Spea_0070 125 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 157962570 Nonpathogen - hypothetical protein Spea_2749 1 None None None 157963251 Common - cytochrome c, putative Spea_3437 7 None None None 157961356 Common - Inosine kinase Spea_1530 60 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 157963813 Common - cytochrome c oxidase subunit III Spea_4002 158 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 157963564 Common - Rod shape-determining protein MreD Spea_3752 61 COG2891 MreD, Cell shape-determining protein Cell envelope biogenesis, outer membrane 157963895 Common - hypothetical protein Spea_4084 13 None None None 157963562 Common - ribonuclease, Rne/Rng family Spea_3750 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 157961400 Common - NADH:ubiquinone oxidoreductase, subunit B Spea_1574 76 COG1805 NqrB, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB Energy production and conversion 157960570 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Spea_0742 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 157961223 Common - S23 ribosomal protein Spea_1396 33 None None None 157962413 Common - peptidase M16 domain protein Spea_2592 196 COG1025 Ptr, Secreted/periplasmic Zn-dependent peptidases, insulinase-like Posttranslational modification, protein turnover, chaperones 157960904 Common - Phosphoketolase Spea_1076 65 COG3957 COG3957, Phosphoketolase Carbohydrate transport and metabolism 157963968 Common - Lysine exporter protein (LYSE/YGGA) Spea_4157 105 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 157960956 Common - twitching motility protein Spea_1128 215 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 157961161 Common - hypothetical protein Spea_1333 12 None None None 157962999 Common - membrane-flanked domain Spea_3182 4 COG3428 COG3428, Predicted membrane protein Function unknown 157961131 Common - type IV pilus biogenesis/stability protein PilW Spea_1303 99 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 157961232 Common - peptidase C26 Spea_1405 95 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 157962588 Common - Resolvase domain Spea_2767 25 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 157962872 Common - Tetratricopeptide TPR_2 repeat protein Spea_3054 59 COG4785 NlpI, Lipoprotein NlpI, contains TPR repeats General function prediction only 157963097 Nonpathogen - monovalent cation/proton antiporter, MnhG/PhaG subunit Spea_3281 1 COG1320 MnhG, Multisubunit Na+/H+ antiporter, MnhG subunit Inorganic ion transport and metabolism 157963862 Common - hypothetical protein Spea_4051 1 None None None 157961217 Common - hypothetical protein Spea_1389 1 None None None 157962738 Nonpathogen - hypothetical protein Spea_2920 2 None None None 157963937 Common - Coproporphyrinogen dehydrogenase Spea_4126 203 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 157961361 Common - DNA topoisomerase I Spea_1535 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 157962909 Common - DNA-directed DNA polymerase Spea_3092 182 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 157962773 Nonpathogen - hypothetical protein Spea_2955 4 None None None 157963839 Common - DSBA oxidoreductase Spea_4028 34 None None None 157960976 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Spea_1148 214 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 157962182 Common - TonB-dependent receptor Spea_2361 118 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 157963328 Common - aldehyde dehydrogenase Spea_3514 221 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 157963914 Common - hypothetical protein Spea_4103 1 None None None 157963304 Common - delta-1-pyrroline-5-carboxylate dehydrogenase Spea_3490 220 COG4230 COG4230, Delta 1-pyrroline-5-carboxylate dehydrogenase Energy production and conversion 157960674 Common - ABC transporter related Spea_0846 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 157963051 Common - hypothetical protein Spea_3234 14 COG2841 COG2841, Uncharacterized protein conserved in bacteria Function unknown 157963943 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Spea_4132 177 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 157960241 Common - type II secretion system protein Spea_0412 144 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 157963656 Common - YicC domain protein Spea_3845 137 COG1561 COG1561, Uncharacterized stress-induced protein Function unknown 157963404 Common - ribonuclease R Spea_3590 203 COG0557 VacB, Exoribonuclease R Transcription 157961636 Common - nitrite reductase (NAD(P)H), small subunit Spea_1812 45 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 157962074 Common - signal peptide peptidase SppA, 67K type Spea_2253 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 157963510 Common - hypothetical protein Spea_3698 4 None None None 157961269 Common - hypothetical protein Spea_1443 8 None None None 157962059 Common - ATP-dependent DNA helicase, RecQ family Spea_2238 237 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 157962185 Common - crossover junction endodeoxyribonuclease RuvC Spea_2364 196 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 157963205 Common - MscS Mechanosensitive ion channel Spea_3390 224 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 157961695 Common - protein of unknown function DUF87 Spea_1871 85 COG0433 COG0433, Predicted ATPase General function prediction only 157962109 Common - ABC transporter related Spea_2288 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 157960605 Common - hypothetical protein Spea_0777 1 None None None 157962159 Common - Protein of unknown function DUF1974 Spea_2338 150 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157961580 Common - two component, sigma54 specific, transcriptional regulator, Fis family Spea_1756 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 157961841 Common - type II secretion system protein Spea_2020 65 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 157961535 Common - amino acid permease-associated region Spea_1710 179 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 157960377 Common - ATP-dependent protease La (LON) domain protein, putative Spea_0548 18 COG2802 COG2802, Uncharacterized protein, similar to the N-terminal domain of Lon protease General function prediction only 157960493 Common - TrkA-C domain protein Spea_0665 95 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 157960664 Common - Tetratricopeptide TPR_2 repeat protein Spea_0836 8 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 157961009 Common - RNA methyltransferase, TrmA family Spea_1181 198 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 157961333 Common - adenine phosphoribosyltransferase Spea_1507 187 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 157961256 Common - anti-sigma-factor antagonist Spea_1430 60 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 157963220 Common - putative periplasmic ligand-binding sensor protein Spea_3406 16 COG3416 COG3416, Uncharacterized protein conserved in bacteria Function unknown 157962839 Common - Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase Spea_3021 200 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 157963010 Common - diguanylate cyclase Spea_3193 174 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 157961689 Common - protein of unknown function DUF482 Spea_1865 81 COG3146 COG3146, Uncharacterized protein conserved in bacteria Function unknown 157961277 Common - fumarylacetoacetate (FAA) hydrolase Spea_1451 47 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 157962190 Common - putative methyltransferase Spea_2369 63 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 157961651 Common - protein of unknown function DUF1425 Spea_1827 12 COG5633 COG5633, Predicted periplasmic lipoprotein General function prediction only 157962530 Nonpathogen - hypothetical protein Spea_2709 1 None None None 157960145 Common - phospholipase Spea_0316 9 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 157962473 Common - hypothetical protein Spea_2652 18 None None None 157963475 Common - Integral membrane protein TerC Spea_3663 218 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 157963456 Common - extracellular solute-binding protein family 5 Spea_3644 193 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 157963733 Common - aminotransferase class V Spea_3922 166 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 157963540 Common - hypothetical protein Spea_3728 9 None None None 157964057 Common - ATP synthase F0, A subunit Spea_4246 206 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 157960271 Common - L-seryl-tRNA(Sec) selenium transferase Spea_0442 74 COG1921 SelA, Selenocysteine synthase [seryl-tRNASer selenium transferase] Amino acid transport and metabolism 157962482 Common - hypothetical protein Spea_2661 9 None None None 157962781 Common - putative lipoprotein Spea_2963 10 None None None 157962848 Common - hypothetical protein Spea_3030 5 None None None 157960961 Common - translation initiation factor SUI1 Spea_1133 47 COG0023 SUI1, Translation initiation factor 1 (eIF-1/SUI1) and related proteins Translation, ribosomal structure and biogenesis 157961048 Common - hypothetical protein Spea_1220 1 None None None 157961746 Common - dTMP kinase Spea_1923 227 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 157963396 Common - hypothetical protein Spea_3582 21 None None None 157962489 Common - shock B family protein Spea_2668 10 None None None 157960513 Common - anaerobic c4-dicarboxylate antiporter, Dcu family Spea_0685 36 COG2704 DcuB, Anaerobic C4-dicarboxylate transporter General function prediction only 157962314 Common - acyl carrier protein Spea_2493 176 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 157960447 Common - hypothetical protein Spea_0618 31 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 157961305 Common - two component transcriptional regulator, LytTR family Spea_1479 202 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 157960596 Common - aldo/keto reductase Spea_0768 201 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 157961525 Common - 3-oxoacyl-(acyl-carrier-protein) synthase III Spea_1700 203 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 157961109 Common - integrase family protein Spea_1281 112 COG0582 XerC, Integrase DNA replication, recombination, and repair 157960829 Common - Adenosylhomocysteine nucleosidase Spea_1001 101 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 157964011 Common - NLP/P60 protein Spea_4200 147 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 157960117 Common - hypothetical protein Spea_0288 12 None None None 157961559 Common - sulfatase Spea_1735 82 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 157959860 Common - methionyl-tRNA formyltransferase Spea_0030 222 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 157963850 Common - Electron transfer flavoprotein alpha/beta-subunit Spea_4039 150 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 157961872 Common - flavodoxin Spea_2051 72 COG0716 FldA, Flavodoxins Energy production and conversion 157961158 Common - sodium:dicarboxylate symporter Spea_1330 150 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 157961569 Common - histidine kinase Spea_1745 208 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157962446 Common - hypothetical protein Spea_2625 11 None None None 157961449 Common - transposase Spea_1623 9 None None None 157960071 Common - hypothetical protein Spea_0242 10 None None None 157964019 Common - autotransporter adhesin Spea_4208 116 None None None 157962374 Common - thioesterase superfamily protein Spea_2553 134 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 157962636 Common - cytoplasmic chaperone TorD family protein Spea_2816 23 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 157961391 Nonpathogen - hypothetical protein Spea_1565 1 None None None 157961982 Common - acetyl-CoA acetyltransferase Spea_2161 187 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 157962440 Common - anaerobic ribonucleoside-triphosphate reductase Spea_2619 98 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 157962398 Common - phosphoribosylformylglycinamidine cyclo-ligase Spea_2577 231 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 157960284 Common - transcriptional regulator, LysR family Spea_0455 84 COG0583 LysR, Transcriptional regulator Transcription 157962606 Common - hypothetical protein Spea_2785 28 COG3126 COG3126, Uncharacterized protein conserved in bacteria Function unknown 157960304 Common - Na+/H+ antiporter NhaC Spea_0475 63 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 157963796 Common - hypothetical protein Spea_3985 1 None None None 157962408 Common - major facilitator superfamily MFS_1 Spea_2587 109 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 157960124 Common - hypothetical protein Spea_0295 8 None None None 157961533 Common - hypothetical protein Spea_1708 31 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 157960479 Common - oxidoreductase Spea_0651 103 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 157960999 Common - putative transcriptional regulator Spea_1171 4 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 157960375 Common - hypothetical protein Spea_0546 33 COG2731 EbgC, Beta-galactosidase, beta subunit Carbohydrate transport and metabolism 157960362 Common - acetyl-CoA carboxylase, biotin carboxyl carrier protein Spea_0533 171 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 157960008 Common - DNA-directed RNA polymerase, beta' subunit Spea_0178 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 157961184 Common - flagellar protein FliS Spea_1356 84 COG1516 FliS, Flagellin-specific chaperone FliS Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 157961957 Common - Enoyl-CoA hydratase/isomerase Spea_2136 182 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 157963241 Common - permease Spea_3427 98 COG0701 COG0701, Predicted permeases General function prediction only 157960762 Common - protein of unknown function DUF861 cupin_3 Spea_0934 31 COG3450 COG3450, Predicted enzyme of the cupin superfamily General function prediction only 157960702 Common - AAA ATPase central domain protein Spea_0874 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 157963524 Common - protein of unknown function DUF1260 Spea_3712 23 COG3076 COG3076, Uncharacterized protein conserved in bacteria Function unknown 157961744 Common - Aminodeoxychorismate lyase Spea_1921 104 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 157962428 Common - hypothetical protein Spea_2607 7 None None None 157962778 Common - Fmu (Sun) domain protein Spea_2960 205 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 157962371 Common - protein of unknown function DUF299 Spea_2550 113 COG1806 COG1806, Uncharacterized protein conserved in bacteria Function unknown 157961830 Common - transposase and inactivated derivative Spea_2009 13 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 157960395 Common - DEAD/DEAH box helicase domain protein Spea_0566 235 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 157960453 Common - NapD family protein Spea_0624 29 COG3062 NapD, Uncharacterized protein involved in formation of periplasmic nitrate reductase Inorganic ion transport and metabolism 157963172 Common - hypothetical protein Spea_3356 16 None None None 157963502 Common - chaperonin Cpn10 Spea_3690 214 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 157961828 Common - sulfatase Spea_2007 31 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 157962768 Common - Indigoidine synthase A family protein Spea_2950 49 COG2313 IndA, Uncharacterized enzyme involved in pigment biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 157963664 Common - transcriptional regulator, GntR family Spea_3853 100 COG1802 GntR, Transcriptional regulators Transcription 157963222 Common - protein of unknown function DUF805 Spea_3408 51 COG3152 COG3152, Predicted membrane protein Function unknown 157960032 Common - ribosomal protein L30 Spea_0202 56 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 157961468 Nonpathogen - TonB family protein Spea_1642 2 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 157963362 Common - ribosome small subunit-dependent GTPase A Spea_3548 163 COG1162 COG1162, Predicted GTPases General function prediction only 157962558 Common - hypothetical protein Spea_2737 14 None None None 157963786 Nonpathogen - hypothetical protein Spea_3975 1 None None None 157962300 Common - Adenosylmethionine decarboxylase Spea_2479 2 None None None 157961776 Common - two component transcriptional regulator, LuxR family Spea_1953 214 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 157963928 Common - molybdopterin converting factor, subunit 1 Spea_4117 72 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 157960248 Common - 2-oxo-acid dehydrogenase E1 subunit, homodimeric type Spea_0419 160 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 157961897 Common - hypothetical protein Spea_2076 61 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 157963169 Common - protein of unknown function DUF924 Spea_3353 63 COG3803 COG3803, Uncharacterized protein conserved in bacteria Function unknown 157961804 Common - NlpBDapX family lipoprotein Spea_1981 35 COG3317 NlpB, Uncharacterized lipoprotein Cell envelope biogenesis, outer membrane 157962009 Common - permease for cytosine/purines uracil thiamine allantoin Spea_2188 59 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 157962894 Common - Dihydrodipicolinate reductase Spea_3076 217 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 157963210 Common - RDD domain containing protein Spea_3395 4 COG1714 COG1714, Predicted membrane protein/domain Function unknown 157963770 Common - hypothetical protein Spea_3959 12 None None None 157964021 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Spea_4210 9 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 157960776 Common - binding-protein-dependent transport systems inner membrane component Spea_0948 209 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 157960545 Common - hypothetical protein Spea_0717 10 None None None 157962525 Common - type IV pilin, putative Spea_2704 5 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 157962732 Common - Penicillin amidase Spea_2914 74 COG2366 COG2366, Protein related to penicillin acylase General function prediction only 157964059 Common - parB-like partition protein Spea_4248 185 COG1475 Spo0J, Predicted transcriptional regulators Transcription 157961176 Common - flagellar rod assembly protein/muramidase FlgJ Spea_1348 72 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 157962351 Common - Arginyltransferase Spea_2530 85 COG2935 COG2935, Putative arginyl-tRNA:protein arginylyltransferase Posttranslational modification, protein turnover, chaperones 157963970 Common - hypothetical protein Spea_4159 1 None None None 157959963 Common - Excinuclease ABC C subunit domain protein Spea_0133 82 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 157961515 Common - hypothetical protein Spea_1690 7 None None None 157962234 Common - oxidoreductase molybdopterin binding Spea_2413 125 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 157962411 Common - Smr protein/MutS2 Spea_2590 75 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 157961901 Common - magnesium and cobalt transport protein CorA Spea_2080 155 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 157964028 Common - phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent Spea_4217 125 COG0696 GpmI, Phosphoglyceromutase Carbohydrate transport and metabolism 157961033 Common - hypothetical protein Spea_1205 4 None None None 157961544 Common - hypothetical protein Spea_1720 14 COG3110 COG3110, Uncharacterized protein conserved in bacteria Function unknown 157961937 Common - pyruvate carboxyltransferase Spea_2116 209 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 157963270 Nonpathogen - hypothetical protein Spea_3456 2 None None None 157963034 Common - hypothetical protein Spea_3217 13 None None None 157960336 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Spea_0507 163 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 157962266 Common - septum site-determining protein MinD Spea_2445 145 COG2894 MinD, Septum formation inhibitor-activating ATPase Cell division and chromosome partitioning 157961425 Common - peptidase S51 dipeptidase E Spea_1599 13 COG3340 PepE, Peptidase E Amino acid transport and metabolism 157961560 Common - ATPase associated with various cellular activities AAA_3 Spea_1736 178 COG0714 COG0714, MoxR-like ATPases General function prediction only 157960068 Common - 3-dehydroquinate synthase Spea_0239 212 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 157961576 Common - poly(R)-hydroxyalkanoic acid synthase, class I Spea_1752 74 COG3243 PhaC, Poly(3-hydroxyalkanoate) synthetase Lipid metabolism 157963757 Common - RNA methyltransferase, TrmH family, group 2 Spea_3946 160 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 157962624 Common - 3-oxoacid CoA-transferase, B subunit Spea_2804 95 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 157962130 Common - sigma-70 region 4 domain protein Spea_2309 82 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 157962746 Common - amidohydrolase Spea_2928 175 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 157963217 Common - hypothetical protein Spea_3403 1 None None None 157962362 Common - Cupin 4 family protein Spea_2541 63 COG2850 COG2850, Uncharacterized conserved protein Function unknown 157962545 Common - Lytic transglycosylase catalytic Spea_2724 113 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 157962098 Common - peptidase S15 Spea_2277 66 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 157962139 Common - protein of unknown function UPF0153 Spea_2318 11 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 157964008 Common - molybdenum cofactor synthesis domain Spea_4197 189 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 157960557 Nonpathogen - hypothetical protein Spea_0729 1 None None None 157962210 Nonpathogen - hypothetical protein Spea_2389 1 None None None 157962850 Common - DNA repair protein RadA Spea_3032 208 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 157961750 Common - putative RNA methylase, NOL1/NOP2/sun family Spea_1927 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 157959885 Common - OmpA/MotB domain protein Spea_0055 112 COG1360 MotB, Flagellar motor protein Cell motility and secretion 157960642 Common - transcriptional regulator, AraC family Spea_0814 107 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 157962393 Common - transposase Spea_2572 9 None None None 157962343 Common - CreA family protein Spea_2522 57 COG3045 CreA, Uncharacterized protein conserved in bacteria Function unknown 157960084 Common - glycine betaine/L-proline ABC transporter, ATPase subunit Spea_0255 249 COG4175 ProV, ABC-type proline/glycine betaine transport system, ATPase component Amino acid transport and metabolism 157960384 Common - short-chain dehydrogenase/reductase SDR Spea_0555 236 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 157962084 Common - threonyl-tRNA synthetase Spea_2263 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 157959943 Common - glycosyl transferase group 1 Spea_0113 156 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 157962711 Common - protein of unknown function DUF446 Spea_2892 32 COG3098 COG3098, Uncharacterized protein conserved in bacteria Function unknown 157961168 Common - flagellar basal-body rod protein FlgB Spea_1340 86 COG1815 FlgB, Flagellar basal body protein Cell motility and secretion 157963727 Common - glutamine synthetase, type I Spea_3916 226 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 157963023 Common - TonB-dependent receptor plug Spea_3206 130 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 157963350 Common - ubiquinol-cytochrome c reductase, iron-sulfur subunit Spea_3536 94 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 157963848 Common - acyl-CoA dehydrogenase domain protein Spea_4037 157 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157962723 Common - beta-lactamase domain protein Spea_2904 45 COG2015 COG2015, Alkyl sulfatase and related hydrolases Secondary metabolites biosynthesis, transport, and catabolism 157962046 Common - hypothetical protein Spea_2225 6 None None None 157961097 Common - helicase domain protein Spea_1269 11 None None None 157962391 Common - OmpA/MotB domain protein Spea_2570 76 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 157962874 Common - diguanylate cyclase/phosphodiesterase Spea_3056 177 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 157959969 Nonpathogen - hypothetical protein Spea_0139 3 None None None 157962345 Common - Rhodanese domain protein Spea_2524 109 COG1054 COG1054, Predicted sulfurtransferase General function prediction only 157961756 Common - putative GAF sensor protein Spea_1933 82 COG1956 COG1956, GAF domain-containing protein Signal transduction mechanisms 157963935 Common - diguanylate cyclase Spea_4124 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157962465 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Spea_2644 143 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 157960886 Common - sodium/hydrogen exchanger Spea_1058 100 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 157960832 Common - transcriptional regulator, MarR family Spea_1004 113 COG1846 MarR, Transcriptional regulators Transcription 157961713 Nonpathogen - hypothetical protein Spea_1890 2 None None None 157961767 Common - protein of unknown function DUF1379 Spea_1944 17 None None None 157963966 Common - hypothetical protein Spea_4155 8 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 157960139 Common - aminoglycoside phosphotransferase Spea_0310 52 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 157961244 Common - UDP-glucose 6-dehydrogenase Spea_1418 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 157959832 Common - DNA polymerase III, beta subunit Spea_0002 215 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 157961196 Common - flagellar motor switch protein FliM Spea_1368 113 COG1868 FliM, Flagellar motor switch protein Cell motility and secretion 157961264 Common - hypothetical protein Spea_1438 17 None None None 157960231 Common - transposase Spea_0402 9 None None None 157962227 Common - Hydroxyacylglutathione hydrolase Spea_2406 133 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 157960238 Common - protein of unknown function DUF1342 Spea_0409 44 COG4582 COG4582, Uncharacterized protein conserved in bacteria Function unknown 157962913 Common - protein of unknown function DUF539 Spea_3096 17 COG2991 COG2991, Uncharacterized protein conserved in bacteria Function unknown 157960110 Common - lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase Spea_0281 109 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 157963435 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Spea_3623 54 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 157961762 Common - protein of unknown function DUF1329 Spea_1939 18 None None None 157961992 Common - Enoyl-CoA hydratase/isomerase Spea_2171 175 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 157962727 Common - PfaB family protein Spea_2908 16 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 157961879 Nonpathogen - hypothetical protein Spea_2058 2 None None None 157962456 Common - aminotransferase class I and II Spea_2635 168 COG3977 COG3977, Alanine-alpha-ketoisovalerate (or valine-pyruvate) aminotransferase Amino acid transport and metabolism 157960414 Common - FxsA cytoplasmic membrane protein Spea_0585 68 COG3030 FxsA, Protein affecting phage T7 exclusion by the F plasmid General function prediction only 157963674 Common - hypothetical protein Spea_3863 1 None None None 157960802 Common - glutamate-1-semialdehyde-2,1-aminomutase Spea_0974 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 157964003 Common - ABC-2 type transporter Spea_4192 30 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 157960841 Common - Glutamate synthase (ferredoxin) Spea_1013 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 157961214 Common - CheW protein Spea_1386 137 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 157960219 Common - putative TIM-barrel protein, nifR3 family Spea_0390 208 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 157962036 Common - cytochrome c oxidase, cbb3-type, subunit II Spea_2215 82 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 157963498 Common - hypothetical protein Spea_3686 7 None None None 157960274 Common - protein of unknown function DUF395 YeeE/YedE Spea_0445 55 COG2391 COG2391, Predicted transporter component General function prediction only 157962788 Common - porin Gram-negative type Spea_2970 44 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 157962610 Common - protein of unknown function DUF925 Spea_2789 22 COG3575 COG3575, Uncharacterized protein conserved in bacteria Function unknown 157960804 Common - prolipoprotein diacylglyceryl transferase Spea_0976 186 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 157963331 Common - Metal-dependent hydrolase HDOD Spea_3517 5 None None None 157962288 Common - lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase Spea_2467 89 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 157961075 Common - transcriptional regulator, AraC family Spea_1247 23 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 157960210 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Spea_0381 71 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 157962304 Common - hypothetical protein Spea_2483 2 None None None 157963683 Common - amidohydrolase Spea_3872 82 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 157961289 Common - response regulator receiver modulated CheW protein Spea_1463 163 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 157962259 Common - Fatty acid metabolism transcriptional regulator FadR Spea_2438 68 COG2186 FadR, Transcriptional regulators Transcription 157960893 Common - peptidylprolyl isomerase FKBP-type Spea_1065 111 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 157961206 Common - RNA polymerase, sigma 28 subunit, FliA/WhiG Spea_1378 216 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 157963881 Common - Integrase catalytic region Spea_4070 134 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157961698 Common - homogentisate 12-dioxygenase Spea_1874 50 COG3508 HmgA, Homogentisate 1,2-dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 157963630 Common - S-adenosyl-methyltransferase MraW Spea_3819 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 157962925 Common - fatty acid hydroxylase Spea_3108 74 COG3000 ERG3, Sterol desaturase Lipid metabolism 157962290 Common - phenylalanyl-tRNA synthetase, beta subunit Spea_2469 246 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 157963551 Common - PGAP1 family protein Spea_3739 4 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 157962264 Common - protein of unknown function DUF709 Spea_2443 34 COG3100 COG3100, Uncharacterized protein conserved in bacteria Function unknown 157962512 Common - FeoA family protein Spea_2691 28 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 157960253 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Spea_0424 185 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 157961810 Common - alpha/beta hydrolase fold Spea_1989 156 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 157960949 Common - putative oxygen-independent coproporphyrinogen III oxidase Spea_1121 205 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 157963071 Common - hypothetical protein Spea_3254 5 None None None 157960939 Common - Glutaminase Spea_1111 72 COG2066 GlsA, Glutaminase Amino acid transport and metabolism 157963412 Common - protease Do Spea_3598 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 157963472 Common - hypothetical protein Spea_3660 5 None None None 157963211 Common - extracellular solute-binding protein family 3 Spea_3397 181 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 157962797 Common - peptidase S9 prolyl oligopeptidase active site domain protein Spea_2979 105 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 157961986 Nonpathogen - hypothetical protein Spea_2165 1 None None None 157962896 Common - peptidase M48 Ste24p Spea_3078 129 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 157960174 Common - acetolactate synthase, large subunit, biosynthetic type Spea_0345 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 157963820 Common - MATE efflux family protein Spea_4009 109 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 157962358 Common - NUDIX hydrolase Spea_2537 64 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 157959984 Common - type II secretion system protein N Spea_0154 10 None None None 157963413 Common - periplasmic serine protease DegS Spea_3599 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 157962462 Common - protein of unknown function DUF1260 Spea_2641 6 None None None 157963234 Common - hypothetical protein Spea_3420 11 COG1289 COG1289, Predicted membrane protein Function unknown 157963842 Common - Alpha/beta hydrolase fold-3 domain protein Spea_4031 132 COG0657 Aes, Esterase/lipase Lipid metabolism 157960799 Common - polynucleotide adenylyltransferase/metal dependent phosphohydrolase Spea_0971 202 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 157963744 Common - two component transcriptional regulator, winged helix family Spea_3933 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157961610 Common - succinate dehydrogenase, flavoprotein subunit Spea_1786 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 157962539 Nonpathogen - hypothetical protein Spea_2718 1 None None None 157962601 Common - Enoyl-CoA hydratase/isomerase Spea_2780 186 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 157960686 Common - hypothetical protein Spea_0858 4 None None None 157963825 Common - hypothetical protein Spea_4014 1 None None None 157962017 Common - peptidase S24 and S26 domain protein Spea_2196 59 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 157959893 Common - flagellin domain protein Spea_0063 127 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 157962069 Common - peptide methionine sulfoxide reductase Spea_2248 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 157963347 Common - Glutathione S-transferase domain Spea_3533 106 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 157962806 Common - MotA/TolQ/ExbB proton channel Spea_2988 89 COG1291 MotA, Flagellar motor component Cell motility and secretion 157963292 Common - hypothetical protein Spea_3478 4 None None None 157963006 Nonpathogen - hypothetical protein Spea_3189 1 None None None 157963833 Common - Arylsulfotransferase Spea_4022 10 None None None 157960682 Common - GTP-binding protein Obg/CgtA Spea_0854 249 COG0536 Obg, Predicted GTPase General function prediction only 157961284 Common - transcriptional regulator, AraC family Spea_1458 115 COG2169 Ada, Adenosine deaminase Nucleotide transport and metabolism 157963909 Common - molybdopterin-guanine dinucleotide biosynthesis protein B Spea_4098 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 157960637 Common - protein of unknown function DUF1063 Spea_0809 35 COG3681 COG3681, Uncharacterized conserved protein Function unknown 157961598 Common - hypothetical protein Spea_1774 8 None None None 157963949 Common - Formate dehydrogenase region TAT target Spea_4138 1 None None None 157964052 Common - ATP synthase F1, gamma subunit Spea_4241 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 157961614 Common - succinyl-CoA synthetase, beta subunit Spea_1790 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 157959918 Common - flagellar motor switch protein FliN Spea_0088 122 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 157960108 Common - Radical SAM domain protein Spea_0279 75 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 157963088 Common - Citrate transporter Spea_3272 59 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 157962679 Common - protein of unknown function UPF0066 Spea_2860 92 COG1720 COG1720, Uncharacterized conserved protein Function unknown 157962165 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Spea_2344 176 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 157960011 Common - translation elongation factor G Spea_0181 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 157961083 Common - integrase family protein Spea_1255 34 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 157962113 Common - UvrD/REP helicase Spea_2292 227 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 157962436 Common - hypothetical protein Spea_2615 2 None None None 157959953 Nonpathogen - hypothetical protein Spea_0123 1 None None None 157961451 Common - DNA topoisomerase III Spea_1625 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 157963876 Common - Oligopeptidase A Spea_4065 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 157962985 Common - exporter of the RND superfamily protein-like protein Spea_3168 56 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 157962502 Common - ATP-dependent Clp protease, proteolytic subunit ClpP Spea_2681 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 157963423 Common - ABC transporter related Spea_3609 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 157962179 Common - electron transport complex, RnfABCDGE type, E subunit Spea_2358 76 COG4660 RnfE, Predicted NADH:ubiquinone oxidoreductase, subunit RnfE Energy production and conversion 157963377 Common - type I secretion outer membrane protein, TolC family Spea_3563 130 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 157963570 Common - methylation site containing protein Spea_3758 11 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 157961484 Common - hypothetical protein Spea_1658 19 None None None 157960329 Common - ferredoxin Spea_0500 37 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 157961271 Common - ferredoxin-type protein NapF Spea_1445 65 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 157962327 Common - peptide methionine sulfoxide reductase Spea_2506 206 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 157963750 Common - flavocytochrome c Spea_3939 200 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 157960721 Common - LrgA family protein Spea_0893 15 COG1380 COG1380, Putative effector of murein hydrolase LrgA General function prediction only 157963297 Common - hypothetical protein Spea_3483 4 None None None 157962278 Common - Histidinol dehydrogenase Spea_2457 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 157963607 Common - twin-arginine translocation protein, TatA/E family subunit Spea_3795 52 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 157963126 Nonpathogen - hypothetical protein Spea_3310 1 None None None 157959879 Common - N-acylneuraminate-9-phosphate synthase Spea_0049 78 COG2089 SpsE, Sialic acid synthase Cell envelope biogenesis, outer membrane 157961974 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Spea_2153 21 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 157960986 Common - acyltransferase 3 Spea_1158 9 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 157963001 Common - beta-lactamase Spea_3184 71 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 157961495 Common - protein of unknown function DUF412 Spea_1670 22 COG3092 COG3092, Uncharacterized protein conserved in bacteria Function unknown 157962842 Common - nucleoside recognition domain protein Spea_3024 20 COG3314 COG3314, Uncharacterized protein conserved in bacteria Function unknown 157960354 Common - Redoxin domain protein Spea_0525 16 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 157960511 Common - protein of unknown function DUF541 Spea_0683 93 COG2968 COG2968, Uncharacterized conserved protein Function unknown 157964062 Common - glucose inhibited division protein A Spea_4251 192 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 157962603 Common - methylmalonate-semialdehyde dehydrogenase Spea_2782 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 157960267 Common - formate dehydrogenase, alpha subunit Spea_0438 171 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 157963153 Common - transcriptional regulator, LysR family Spea_3337 169 COG0583 LysR, Transcriptional regulator Transcription 157960293 Common - band 7 protein Spea_0464 216 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 157960193 Common - OmpA/MotB domain protein Spea_0364 136 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 157960588 Common - glucosamine-6-phosphate isomerase Spea_0760 97 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 157960793 Common - dihydroneopterin aldolase Spea_0965 104 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 157961253 Nonpathogen - hypothetical protein Spea_1427 4 None None None 157960154 Common - flavocytochrome c Spea_0325 208 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 157961113 Common - SmpA/OmlA domain protein Spea_1285 61 COG2913 SmpA, Small protein A (tmRNA-binding) Translation, ribosomal structure and biogenesis 157960045 Common - cytochrome c class I Spea_0216 46 COG3245 CycB, Cytochrome c5 Energy production and conversion 157961518 Common - DSBA oxidoreductase Spea_1693 68 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 157963119 Common - glycine cleavage system T protein Spea_3303 178 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 157963625 Common - phospho-N-acetylmuramoyl-pentapeptide-transferase Spea_3814 219 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 157962958 Common - apolipoprotein N-acyltransferase Spea_3141 167 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 157960869 Common - holo-acyl-carrier-protein synthase Spea_1041 95 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 157961674 Common - hypothetical protein Spea_1850 7 COG1289 COG1289, Predicted membrane protein Function unknown 157960486 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Spea_0658 196 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 157963106 Nonpathogen - hypothetical protein Spea_3290 1 None None None 157961970 Common - enzyme Spea_2149 7 None None None 157960649 Common - phosphoribosyltransferase Spea_0821 41 COG2236 COG2236, Predicted phosphoribosyltransferases General function prediction only 157962582 Common - transcriptional antiterminator, Rof Spea_2761 4 COG4568 Rof, Transcriptional antiterminator Transcription 157961323 Nonpathogen - hypothetical protein Spea_1497 1 None None None 157960749 Common - major facilitator superfamily MFS_1 Spea_0921 61 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 157963277 Common - integrase family protein Spea_3463 8 None None None 157963192 Common - cobyric acid synthase CobQ Spea_3377 153 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 157960228 Common - DEAD/DEAH box helicase domain protein Spea_0399 236 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 157963600 Common - phosphoesterase PA-phosphatase related Spea_3788 104 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 157962625 Common - aminoglycoside phosphotransferase Spea_2805 6 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 157960077 Common - protein of unknown function DUF6 transmembrane Spea_0248 87 COG2962 RarD, Predicted permeases General function prediction only 157961502 Common - sodium/pantothenate symporter Spea_1677 179 COG4145 PanF, Na+/panthothenate symporter Coenzyme metabolism 157961372 Common - lipoprotein releasing system, ATP-binding protein Spea_1546 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 157961318 Common - Fe-S protein assembly chaperone HscA Spea_1492 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 157963443 Common - histidine kinase Spea_3631 192 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157961796 Common - protein of unknown function UPF0118 Spea_1973 115 COG0628 PerM, Predicted permease General function prediction only 157961693 Common - Lysine exporter protein (LYSE/YGGA) Spea_1869 91 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 157963980 Common - urocanate hydratase Spea_4169 97 COG2987 HutU, Urocanate hydratase Amino acid transport and metabolism 157959926 Common - oxygen-independent coproporphyrinogen III oxidase Spea_0096 203 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 157962336 Common - sortase family protein Spea_2515 17 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 157963534 Common - GumN family protein Spea_3722 43 COG3735 COG3735, Uncharacterized protein conserved in bacteria Function unknown 157961028 Common - sodium ion-translocating decarboxylase, beta subunit Spea_1200 56 COG1883 OadB, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit Energy production and conversion 157963380 Common - protein of unknown function DUF461 Spea_3566 81 COG2847 COG2847, Uncharacterized protein conserved in bacteria Function unknown 157961563 Common - von Willebrand factor type A Spea_1739 65 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 157959853 Common - transposase Spea_0023 9 None None None 157960562 Common - hypothetical protein Spea_0734 2 None None None 157961182 Common - flagellar hook-associated 2 domain protein Spea_1354 102 COG1345 FliD, Flagellar capping protein Cell motility and secretion 157962938 Common - 2-dehydro-3-deoxyphosphooctonate aldolase Spea_3121 185 COG2877 KdsA, 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase Cell envelope biogenesis, outer membrane 157960917 Common - type IV pilus assembly protein PilX Spea_1089 2 COG4726 PilX, Tfp pilus assembly protein PilX Cell motility and secretion / Intracellular trafficking and secretion 157962149 Common - cation diffusion facilitator family transporter Spea_2328 163 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 157963579 Common - MSHA biogenesis protein MshM Spea_3767 69 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 157960874 Common - protein of unknown function DUF21 Spea_1046 218 COG4536 CorB, Putative Mg2+ and Co2+ transporter CorB Inorganic ion transport and metabolism 157960930 Common - N-acetylglucosamine-6-phosphate deacetylase Spea_1102 118 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 157960550 Common - flavocytochrome c Spea_0722 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 157963987 Common - hypothetical protein Spea_4176 27 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 157959971 Common - Hsp33 protein Spea_0141 137 COG1281 COG1281, Disulfide bond chaperones of the HSP33 family Posttranslational modification, protein turnover, chaperones 157960901 Common - Glucose-6-phosphate isomerase Spea_1073 197 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 157961964 Common - acyl-CoA dehydrogenase domain protein Spea_2143 137 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157960088 Common - hypothetical protein Spea_0259 7 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 157961143 Common - CMP/dCMP deaminase zinc-binding Spea_1315 216 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 157963774 Common - protein of unknown function DUF1332 Spea_3963 30 COG4103 COG4103, Uncharacterized protein conserved in bacteria Function unknown 157959871 Common - protein of unknown function DUF1488 Spea_0041 5 None None None 157961071 Common - diguanylate phosphodiesterase Spea_1243 163 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 157960630 Common - DEAD/DEAH box helicase domain protein Spea_0802 235 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 157962284 Common - phosphoribosyl-AMP cyclohydrolase Spea_2463 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 157963735 Common - transcriptional regulator, AsnC family Spea_3924 152 COG1522 Lrp, Transcriptional regulators Transcription 157960928 Common - Beta-N-acetylhexosaminidase Spea_1100 46 COG3525 Chb, N-acetyl-beta-hexosaminidase Carbohydrate transport and metabolism 157961809 Common - Carbonate dehydratase Spea_1988 151 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 157961813 Common - arsenate reductase and related Spea_1992 114 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 157960834 Common - putative transporter, BCCT family protein Spea_1006 74 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 157961021 Common - RNA polymerase, sigma 70 subunit, RpoD family Spea_1193 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 157961189 Common - flagellar M-ring protein FliF Spea_1361 124 COG1766 FliF, Flagellar biosynthesis/type III secretory pathway lipoprotein Cell motility and secretion / Intracellular trafficking and secretion 157962065 Common - Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase Spea_2244 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 157963990 Common - hypothetical protein Spea_4179 5 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 157963678 Common - oligopeptide transporter, OPT superfamily Spea_3867 42 COG1297 COG1297, Predicted membrane protein Function unknown 157962931 Common - protein of unknown function DUF520 Spea_3114 107 COG1666 COG1666, Uncharacterized protein conserved in bacteria Function unknown 157962500 Common - ATP-dependent protease La Spea_2679 218 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 157960690 Common - dimethyladenosine transferase Spea_0862 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 157962660 Common - putative hydrolase Spea_2841 27 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 157960837 Common - transcriptional regulator, TetR family Spea_1009 37 COG1309 AcrR, Transcriptional regulator Transcription 157960773 Common - Glutamate--putrescine ligase Spea_0945 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 157960490 Common - uroporphyrin-III C-methyltransferase Spea_0662 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 157960140 Common - DSBA oxidoreductase Spea_0311 70 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 157963223 Common - hypothetical protein Spea_3409 2 None None None 157960697 Common - hypothetical protein Spea_0869 5 None None None 157963795 Nonpathogen - hypothetical protein Spea_3984 1 None None None 157962177 Common - electron transport complex, RnfABCDGE type, D subunit Spea_2356 76 COG4658 RnfD, Predicted NADH:ubiquinone oxidoreductase, subunit RnfD Energy production and conversion 157961981 Common - acyl-CoA dehydrogenase domain protein Spea_2160 122 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157961799 Common - transposase Spea_1976 9 None None None 157963256 Common - glycosyl transferase group 1 Spea_3442 189 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 157960853 Common - Na+/H+ antiporter NhaA Spea_1025 106 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 157961087 Common - DNA repair protein RadC Spea_1259 173 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 157962943 Common - peptide chain release factor 1 Spea_3126 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 157961667 Common - protein of unknown function UPF0118 Spea_1843 51 COG0628 PerM, Predicted permease General function prediction only 157962202 Common - UBA/THIF-type NAD/FAD binding protein Spea_2381 213 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 157960860 Common - anti sigma-E protein, RseA Spea_1032 25 COG3073 RseA, Negative regulator of sigma E activity Signal transduction mechanisms 157961658 Common - GCN5-related N-acetyltransferase Spea_1834 104 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 157960922 Common - type IV pilus biogenesis protein, putative Spea_1094 18 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 157963196 Common - transport system permease protein Spea_3381 192 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 157960730 Common - DNA polymerase III chi subunit HolC Spea_0902 59 COG2927 HolC, DNA polymerase III, chi subunit DNA replication, recombination, and repair 157960844 Common - transcriptional regulator, LysR family Spea_1016 164 COG0583 LysR, Transcriptional regulator Transcription 157962792 Common - diguanylate cyclase Spea_2974 179 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157960103 Nonpathogen - hypothetical protein Spea_0274 1 None None None 157961126 Common - GCN5-related N-acetyltransferase Spea_1298 37 COG0456 RimI, Acetyltransferases General function prediction only 157961128 Common - 5'-nucleotidase Spea_1300 131 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 157962252 Common - putative signal transduction protein with CBS domains Spea_2431 76 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 157962645 Common - MoxR-like protein ATPase-like protein Spea_2825 33 COG0714 COG0714, MoxR-like ATPases General function prediction only 157961662 Common - Multidrug resistance efflux pump-like protein Spea_1838 15 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 157962140 Common - putative AcnD-accessory protein PrpF Spea_2319 55 COG2828 COG2828, Uncharacterized protein conserved in bacteria Function unknown 157960729 Common - valyl-tRNA synthetase Spea_0901 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 157960062 Common - type IV pilus assembly protein PilM Spea_0233 81 COG4972 PilM, Tfp pilus assembly protein, ATPase PilM Cell motility and secretion / Intracellular trafficking and secretion 157961297 Common - preprotein translocase, YajC subunit Spea_1471 176 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 157963145 Common - MotA/TolQ/ExbB proton channel Spea_3329 3 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 157962898 Common - chaperone protein DnaK Spea_3080 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 157964006 Nonpathogen - hypothetical protein Spea_4195 1 None None None 157962569 Common - transcriptional regulator, LysR family Spea_2748 108 COG0583 LysR, Transcriptional regulator Transcription 157963128 Common - protein of unknown function DUF1326 Spea_3312 17 COG5588 COG5588, Uncharacterized conserved protein Function unknown 157961570 Common - two component transcriptional regulator, winged helix family Spea_1746 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157962025 Common - trimethyllysine dioxygenase Spea_2204 7 COG2175 TauD, Probable taurine catabolism dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 157960608 Common - hypothetical protein Spea_0780 1 None None None 157960912 Common - lipoprotein signal peptidase Spea_1084 206 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 157961411 Common - tryptophan synthase, alpha subunit Spea_1585 213 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 157962974 Common - ribosomal-protein-alanine acetyltransferase Spea_3157 176 COG0456 RimI, Acetyltransferases General function prediction only 157960325 Common - hypothetical protein Spea_0496 2 None None None 157962562 Common - choline/carnitine/betaine transporter Spea_2741 96 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 157960020 Common - ribosomal protein S3 Spea_0190 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 157962585 Common - rod shape-determining protein RodA Spea_2764 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 157963596 Common - purine nucleoside phosphorylase Spea_3784 96 COG0813 DeoD, Purine-nucleoside phosphorylase Nucleotide transport and metabolism 157962644 Nonpathogen - hypothetical protein Spea_2824 1 None None None 157961491 Common - hypothetical protein Spea_1666 128 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 157962651 Common - hypothetical protein Spea_2831 2 None None None 157962180 Common - endonuclease III Spea_2359 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 157963877 Common - hypothetical protein Spea_4066 2 None None None 157961584 Common - lysophospholipase-like protein Spea_1760 22 COG2267 PldB, Lysophospholipase Lipid metabolism 157963402 Common - Prolyl oligopeptidase Spea_3588 117 COG1505 COG1505, Serine proteases of the peptidase family S9A Amino acid transport and metabolism 157961322 Common - protein of unknown function DUF528 Spea_1496 43 COG2975 COG2975, Uncharacterized protein conserved in bacteria Function unknown 157963280 Common - AFG1-family ATPase Spea_3466 94 COG1485 COG1485, Predicted ATPase General function prediction only 157961602 Common - hypothetical protein Spea_1778 2 None None None 157961714 Common - transcriptional regulator, XRE family Spea_1891 30 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 157963092 Common - peptidase T-like protein Spea_3276 147 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 157963605 Common - Sterol-binding domain protein Spea_3793 31 COG3165 COG3165, Uncharacterized protein conserved in bacteria Function unknown 157963939 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Spea_4128 175 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 157961455 Common - methyl-accepting chemotaxis sensory transducer with Cache sensor Spea_1629 148 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157961759 Common - aminopeptidase N Spea_1936 160 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 157961977 Common - Enoyl-CoA hydratase/isomerase Spea_2156 176 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 157960559 Common - Inositol phosphatase/fructose-16-bisphosphatase Spea_0731 108 COG0158 Fbp, Fructose-1,6-bisphosphatase Carbohydrate transport and metabolism 157963916 Common - SNARE associated Golgi protein Spea_4105 21 COG0398 COG0398, Uncharacterized conserved protein Function unknown 157960671 Common - oxidoreductase FAD/NAD(P)-binding domain protein Spea_0843 113 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 157960899 Common - Hemerythrin HHE cation binding domain protein Spea_1071 14 COG3945 COG3945, Uncharacterized conserved protein Function unknown 157962509 Common - protein of unknown function DUF1282 Spea_2688 24 None None None 157961843 Common - TPR repeat-containing protein Spea_2022 93 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 157963302 Common - phosphate transporter Spea_3488 173 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 157962775 Common - Dystroglycan-type cadherin domain protein Spea_2957 8 None None None 157963058 Common - protein of unknown function DUF985 Spea_3241 57 COG3542 COG3542, Uncharacterized conserved protein Function unknown 157959851 Common - potassium uptake protein, TrkH family Spea_0021 122 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 157961945 Common - AMP-dependent synthetase and ligase Spea_2124 222 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 157959934 Common - Rhomboid family protein Spea_0104 111 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 157961335 Common - hypothetical protein Spea_1509 115 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 157961578 Common - hypothetical protein Spea_1754 3 None None None 157960319 Nonpathogen - hypothetical protein Spea_0490 1 None None None 157963399 Common - single-strand binding protein/Primosomal replication protein n Spea_3585 24 COG2965 PriB, Primosomal replication protein N DNA replication, recombination, and repair 157960286 Common - MscS Mechanosensitive ion channel Spea_0457 178 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 157960449 Common - Nitrate reductase cytochrome c-type subunit (NapB) Spea_0620 41 COG3043 NapB, Nitrate reductase cytochrome c-type subunit Energy production and conversion 157962312 Common - hypothetical protein Spea_2491 1 None None None 157962495 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Spea_2674 249 COG4170 SapD, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 157962614 Common - 1,4-dihydroxy-2-naphthoate octaprenyltransferase Spea_2793 97 COG1575 MenA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase Coenzyme metabolism 157960676 Common - Cupin 2 conserved barrel domain protein Spea_0848 44 COG3837 COG3837, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 157963798 Common - hypothetical protein Spea_3987 15 None None None 157963390 Common - histidine kinase A domain protein Spea_3576 104 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157963835 Common - Disulphide bond formation protein DsbB Spea_4024 28 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 157960598 Common - protein of unknown function DUF84 Spea_0770 34 COG1986 COG1986, Uncharacterized conserved protein Function unknown 157960995 Common - thiamine-monophosphate kinase Spea_1167 194 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 157962888 Common - protein-export membrane protein SecF Spea_3070 213 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 157963542 Common - response regulator receiver protein Spea_3730 182 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 157963473 Common - hypothetical protein Spea_3661 13 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 157963958 Common - flagellar basal body-associated protein FliL Spea_4147 18 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 157963483 Common - pentapeptide repeat protein Spea_3671 86 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 157961711 Nonpathogen - cell death peptidase, inhibitor of T4 late gene expression Spea_1887 3 None None None 157962721 Common - GTP cyclohydrolase I Spea_2902 73 COG2904 COG2904, Uncharacterized protein conserved in bacteria Function unknown 157962756 Common - serine/threonine protein kinase Spea_2938 41 COG4886 COG4886, Leucine-rich repeat (LRR) protein Function unknown 157963715 Common - Rhodanese domain protein Spea_3904 65 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 157963945 Common - Formate dehydrogenase region TAT target Spea_4134 2 None None None 157963454 Common - binding-protein-dependent transport systems inner membrane component Spea_3642 171 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 157960308 Common - cytochrome c, putative Spea_0479 6 None None None 157964055 Common - ATP synthase F0, B subunit Spea_4244 154 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 157963344 Common - periplasmic binding protein Spea_3530 119 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 157961523 Common - Exonuclease RNase T and DNA polymerase III Spea_1698 97 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 157960713 Common - short-chain dehydrogenase/reductase SDR Spea_0885 233 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 157960963 Common - hypothetical protein Spea_1135 20 None None None 157963185 Common - tetraheme cytochrome c Spea_3370 6 None None None 157960814 Common - hypothetical protein Spea_0986 1 None None None 157962041 Common - cytochrome oxidase maturation protein, cbb3-type Spea_2220 15 COG3197 FixS, Uncharacterized protein, possibly involved in nitrogen fixation Inorganic ion transport and metabolism 157962072 Common - hypothetical protein Spea_2251 19 COG3111 COG3111, Uncharacterized conserved protein Function unknown 157964043 Nonpathogen - hypothetical protein Spea_4232 2 None None None 157960262 Common - transcriptional regulator, MerR family Spea_0433 143 COG0789 SoxR, Predicted transcriptional regulators Transcription 157960119 Common - hypothetical protein Spea_0290 2 None None None 157962510 Common - glutaminyl-tRNA synthetase Spea_2689 241 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 157963326 Common - histidine kinase Spea_3512 210 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157962053 Common - outer membrane lipoprotein carrier protein LolA Spea_2232 68 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 157962961 Common - Rare lipoprotein B Spea_3144 28 COG2980 RlpB, Rare lipoprotein B Cell envelope biogenesis, outer membrane 157962980 Nonpathogen - hypothetical protein Spea_3163 2 None None None 157960525 Common - glutamyl-tRNA synthetase class Ic Spea_0697 247 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 157961771 Common - ABC transporter related Spea_1948 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 157963513 Common - hypothetical protein Spea_3701 19 None None None 157963555 Common - ABC-2 type transporter Spea_3743 40 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 157960023 Common - ribosomal protein S17 Spea_0193 236 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 157962702 Common - uridylate kinase Spea_2883 232 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 157960518 Common - ABC-2 type transporter Spea_0690 137 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 157960263 Common - permease Spea_0434 85 COG0701 COG0701, Predicted permeases General function prediction only 157962639 Common - outer membrane protein Spea_2819 9 None None None 157961394 Common - glutathione-dependent formaldehyde-activating GFA Spea_1568 63 COG3791 COG3791, Uncharacterized conserved protein Function unknown 157963893 Common - ThiJ/PfpI domain protein Spea_4082 88 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 157963253 Common - hypothetical protein Spea_3439 1 None None None 157963300 Common - adenylate cyclase Spea_3486 57 COG3025 COG3025, Uncharacterized conserved protein Function unknown 157963707 Common - outer membrane lipoprotein carrier protein LolA Spea_3896 26 None None None 157963868 Common - AbgT putative transporter Spea_4057 41 COG2978 AbgT, Putative p-aminobenzoyl-glutamate transporter Coenzyme metabolism 157960997 Common - DNA repair protein RecN Spea_1169 203 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 157962680 Common - transferase hexapeptide repeat containing protein Spea_2861 219 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 157963622 Common - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Spea_3811 208 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 157961294 Common - protein of unknown function DUF479 Spea_1468 33 COG3124 COG3124, Uncharacterized protein conserved in bacteria Function unknown 157963069 Common - protein of unknown function DUF6 transmembrane Spea_3252 46 COG2962 RarD, Predicted permeases General function prediction only 157963696 Common - hypothetical protein Spea_3885 12 None None None 157962997 Common - hypothetical protein Spea_3180 1 None None None 157963043 Common - LVIVD repeat protein Spea_3226 3 COG5276 COG5276, Uncharacterized conserved protein Function unknown 157962271 Common - hypothetical protein Spea_2450 21 COG4798 COG4798, Predicted methyltransferase General function prediction only 157960823 Common - tyrosyl-tRNA synthetase Spea_0995 240 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 157963954 Common - formate dehydrogenase subunit FdhD Spea_4143 136 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 157960579 Nonpathogen - hypothetical protein Spea_0751 1 None None None 157960209 Common - tyrosine recombinase XerC Spea_0380 225 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 157963953 Common - hypothetical protein Spea_4142 6 None None None 157961808 Common - 3-deoxy-D-manno-octulosonate cytidylyltransferase Spea_1985 147 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 157963464 Common - beta-lactamase domain protein Spea_3652 125 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 157964032 Common - transcriptional regulator, BadM/Rrf2 family Spea_4221 152 COG1959 COG1959, Predicted transcriptional regulator Transcription 157963805 Common - transcriptional regulator, AraC family Spea_3994 3 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 157962709 Common - flavodoxin/nitric oxide synthase Spea_2890 75 COG0716 FldA, Flavodoxins Energy production and conversion 157963371 Common - L-sorbosone dehydrogenase, putative Spea_3557 64 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 157963586 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) Spea_3774 194 COG0281 SfcA, Malic enzyme Energy production and conversion 157960428 Common - glutathione synthetase Spea_0599 126 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 157960723 Common - protein of unknown function UPF0057 Spea_0895 2 COG0401 COG0401, Uncharacterized homolog of Blt101 Function unknown 157960499 Common - putative lipoprotein Spea_0671 19 COG3489 COG3489, Predicted periplasmic lipoprotein General function prediction only 157963635 Common - membrane protein involved in aromatic hydrocarbon degradation Spea_3824 77 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 157961078 Common - alkylhydroperoxidase-like protein, AhpD family Spea_1250 72 COG2128 COG2128, Uncharacterized conserved protein Function unknown 157962907 Common - peptidase M17 leucyl aminopeptidase domain protein Spea_3090 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 157961234 Common - CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase Spea_1407 8 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 157963815 Common - hypothetical protein Spea_4004 25 None None None 157961354 Common - Nucleoside-triphosphate--adenylate kinase Spea_1528 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 157963167 Common - membrane-flanked domain Spea_3351 26 COG3402 COG3402, Uncharacterized conserved protein Function unknown 157963099 Common - NADH-ubiquinone oxidoreductase chain 4L Spea_3283 99 COG1006 MnhC, Multisubunit Na+/H+ antiporter, MnhC subunit Inorganic ion transport and metabolism 157961463 Common - methyl-accepting chemotaxis sensory transducer Spea_1637 121 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157962553 Nonpathogen - hypothetical protein Spea_2732 1 None None None 157962527 Common - hypothetical protein Spea_2706 2 None None None 157963337 Nonpathogen - MotA/TolQ/ExbB proton channel Spea_3523 2 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 157962463 Common - RNA-binding S4 domain protein Spea_2642 53 COG2501 COG2501, Uncharacterized conserved protein Function unknown 157963062 Common - SpoOM family protein Spea_3245 20 COG4326 Spo0M, Sporulation control protein General function prediction only 157963354 Common - RNA chaperone Hfq Spea_3540 127 COG1923 Hfq, Uncharacterized host factor I protein General function prediction only 157962599 Common - 3-hydroxyisobutyrate dehydrogenase Spea_2778 166 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 157960463 Common - Na+ dependent nucleoside transporter domain protein Spea_0634 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 157962353 Common - ATP-dependent Clp protease, ATP-binding subunit clpA Spea_2532 220 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 157963864 Common - multi antimicrobial extrusion protein MatE Spea_4053 127 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 157962519 Common - decaheme cytochrome c Spea_2698 8 None None None 157960051 Common - transposase IS116/IS110/IS902 family protein Spea_0222 98 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 157962384 Common - Peptidoglycan-associated lipoprotein Spea_2563 150 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 157963569 Common - methylation site containing protein Spea_3757 12 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 157960198 Common - putative outer membrane adhesin like proteiin Spea_0369 121 None None None 157961367 Common - acylphosphatase Spea_1541 91 COG1254 AcyP, Acylphosphatases Energy production and conversion 157961054 Common - NAD(P)H dehydrogenase (quinone) Spea_1226 72 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 157963285 Nonpathogen - hypothetical protein Spea_3471 3 None None None 157960619 Common - fructose-bisphosphate aldolase, class II, Calvin cycle subtype Spea_0791 176 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 157962460 Common - transcriptional regulator, LysR family Spea_2639 169 COG0583 LysR, Transcriptional regulator Transcription 157960137 Common - protein of unknown function UPF0061 Spea_0308 110 COG0397 COG0397, Uncharacterized conserved protein Function unknown 157963076 Common - Na+/H+ antiporter NhaC Spea_3259 46 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 157961406 Common - NADH:ubiquinone oxidoreductase, subunit F Spea_1580 14 COG2871 NqrF, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF Energy production and conversion 157963907 Common - ABC transporter related Spea_4096 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 157961095 Common - hypothetical protein Spea_1267 9 None None None 157962547 Nonpathogen - hypothetical protein Spea_2726 2 None None None 157962236 Common - Lytic transglycosylase catalytic Spea_2415 153 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 157961950 Common - Acyl-CoA dehydrogenase type 2 domain Spea_2129 53 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157963244 Common - peptidase S8 and S53 subtilisin kexin sedolisin Spea_3430 57 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 157961802 Common - amino acid-binding ACT domain protein Spea_1979 39 COG2716 GcvR, Glycine cleavage system regulatory protein Amino acid transport and metabolism 157963342 Common - ABC transporter related Spea_3528 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 157962551 Common - Glutathione S-transferase domain Spea_2730 31 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 157963462 Common - extracellular solute-binding protein family 3 Spea_3650 62 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 157962970 Common - Serine-type D-Ala-D-Ala carboxypeptidase Spea_3153 155 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 157962761 Common - peptidase T Spea_2943 62 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 157961103 Common - hypothetical protein Spea_1275 8 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 157963972 Nonpathogen - hypothetical protein Spea_4161 4 COG3450 COG3450, Predicted enzyme of the cupin superfamily General function prediction only 157962795 Common - hypothetical protein Spea_2977 4 None None None 157961752 Common - Mammalian cell entry related domain protein Spea_1929 56 COG3008 PqiB, Paraquat-inducible protein B General function prediction only 157962309 Common - Cytidine deaminase Spea_2488 37 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 157961530 Common - proline racemase Spea_1705 47 COG3938 COG3938, Proline racemase Amino acid transport and metabolism 157962417 Nonpathogen - hypothetical protein Spea_2596 1 None None None 157959936 Common - L-threonine 3-dehydrogenase Spea_0106 208 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 157960334 Common - peptidylprolyl isomerase FKBP-type Spea_0505 132 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 157960668 Common - hypothetical protein Spea_0840 1 None None None 157963064 Common - BCCT transporter Spea_3247 95 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 157961705 Common - protein of unknown function DUF307 Spea_1881 43 COG3304 COG3304, Predicted membrane protein Function unknown 157963761 Common - hypothetical protein Spea_3950 3 None None None 157960147 Common - alpha/beta hydrolase fold Spea_0318 131 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 157960168 Common - cytochrome c Spea_0339 6 None None None 157960452 Common - periplasmic nitrate reductase, large subunit Spea_0623 184 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 157962859 Common - two component transcriptional regulator, LuxR family Spea_3041 194 COG4566 TtrR, Response regulator Signal transduction mechanisms 157960082 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Spea_0253 209 COG0313 COG0313, Predicted methyltransferases General function prediction only 157959998 Common - biotin--acetyl-CoA-carboxylase ligase Spea_0168 226 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 157961754 Common - Paraquat-inducible protein A Spea_1931 54 COG2995 PqiA, Uncharacterized paraquat-inducible protein A Function unknown 157962622 Common - pyruvate carboxyltransferase Spea_2802 202 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 157961212 Common - Cobyrinic acid ac-diamide synthase Spea_1384 223 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 157960890 Common - cytochrome c class II Spea_1062 35 COG3909 COG3909, Cytochrome c556 Energy production and conversion 157961068 Common - hypothetical protein Spea_1240 7 None None None 157961220 Common - amino acid/peptide transporter Spea_1393 79 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 157961739 Common - Integrase catalytic region Spea_1916 142 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157961194 Common - flagellar hook-length control protein Spea_1366 50 COG3144 FliK, Flagellar hook-length control protein Cell motility and secretion 157962044 Common - UspA domain protein Spea_2223 81 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 157962341 Common - cystathionine beta-lyase Spea_2520 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 157960053 Common - protein of unknown function DUF1439 Spea_0224 21 None None None 157963679 Common - OmpA/MotB domain protein Spea_3868 109 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 157960397 Common - hypothetical protein Spea_0568 1 None None None 157961241 Common - sugar transferase Spea_1414 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 157960758 Common - protein of unknown function DUF368 Spea_0930 50 COG2035 COG2035, Predicted membrane protein Function unknown 157961858 Common - para-aminobenzoate synthase, subunit I Spea_2037 223 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 157963672 Common - anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family Spea_3861 182 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 157962713 Common - hypothetical protein Spea_2894 5 None None None 157960527 Common - sugar fermentation stimulation protein Spea_0699 109 COG1489 SfsA, DNA-binding protein, stimulates sugar fermentation General function prediction only 157961861 Nonpathogen - hypothetical protein Spea_2040 1 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 157962325 Common - ribonuclease, Rne/Rng family Spea_2504 186 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 157962637 Common - Dimethylsulfoxide reductase chain B Spea_2817 163 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 157963846 Common - AMP-dependent synthetase and ligase Spea_4035 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 157961041 Common - hypothetical protein Spea_1213 1 None None None 157961781 Common - protein of unknown function DUF882 Spea_1958 62 COG3108 COG3108, Uncharacterized protein conserved in bacteria Function unknown 157961723 Common - MscS Mechanosensitive ion channel Spea_1900 150 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 157963536 Common - diguanylate cyclase/phosphodiesterase Spea_3724 166 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 157960044 Common - heme exporter protein CcmA Spea_0215 249 COG4133 CcmA, ABC-type transport system involved in cytochrome c biogenesis, ATPase component Posttranslational modification, protein turnover, chaperones 157960708 Common - MltA-interacting MipA family protein Spea_0880 24 COG3713 OmpV, Outer membrane protein V Cell envelope biogenesis, outer membrane 157962444 Common - Patatin Spea_2623 126 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 157961627 Common - Methyltransferase type 11 Spea_1803 103 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 157962824 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Spea_3006 196 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 157963852 Common - FAD dependent oxidoreductase Spea_4041 156 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 157962372 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Spea_2551 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 157962745 Nonpathogen - hypothetical protein Spea_2927 1 None None None 157961461 Common - beta-lactamase domain protein Spea_1635 213 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 157959845 Common - Integrase catalytic region Spea_0015 142 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157961870 Common - Elongation factor P Spea_2049 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 157960101 Common - hypothetical protein Spea_0272 11 None None None 157960778 Common - FAD dependent oxidoreductase Spea_0950 130 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 157960360 Nonpathogen - hypothetical protein Spea_0531 1 None None None 157960399 Common - major facilitator superfamily MFS_1 Spea_0570 134 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 157962458 Common - Beta-lactamase Spea_2637 38 COG2602 COG2602, Beta-lactamase class D Defense mechanisms 157960543 Common - amino acid carrier protein Spea_0715 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 157963910 Common - molybdenum cofactor biosynthesis protein A Spea_4099 195 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 157961557 Common - two component transcriptional regulator, LuxR family Spea_1733 207 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 157961156 Common - hypothetical protein Spea_1328 6 None None None 157963526 Common - ABC-3 protein Spea_3714 10 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 157963985 Nonpathogen - protein of unknown function DUF214 Spea_4174 3 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 157963979 Common - histidine ammonia-lyase Spea_4168 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 157961299 Common - protein-export membrane protein SecF Spea_1473 201 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 157961656 Common - DoxX family protein Spea_1832 19 COG2259 COG2259, Predicted membrane protein Function unknown 157961903 Common - D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase Spea_2082 89 COG2027 DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) Cell envelope biogenesis, outer membrane 157960130 Common - anti-sigma-factor antagonist Spea_0301 45 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 157960369 Common - efflux transporter, RND family, MFP subunit Spea_0540 112 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 157961832 Common - AAA ATPase Spea_2011 27 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 157962471 Common - MotA/TolQ/ExbB proton channel Spea_2650 84 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 157962692 Common - acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase Spea_2873 160 COG1043 LpxA, Acyl- acyl carrier protein 157962220 Common - hypothetical protein Spea_2399 3 COG3904 COG3904, Predicted periplasmic protein Function unknown 157959847 Common - acetyl-CoA C-acyltransferase FadA Spea_0017 187 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 157961687 Common - Inosine/uridine-preferring nucleoside hydrolase Spea_1863 88 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 157960089 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Spea_0260 129 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 157960825 Common - hypothetical protein Spea_0997 1 None None None 157960034 Common - preprotein translocase, SecY subunit Spea_0204 232 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 157961918 Nonpathogen - hypothetical protein Spea_2097 1 None None None 157962217 Nonpathogen - hypothetical protein Spea_2396 1 None None None 157961539 Common - hypothetical protein Spea_1715 6 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 157960700 Common - hypothetical protein Spea_0872 14 None None None 157960381 Common - histidine kinase Spea_0552 69 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157961939 Common - 4-oxalocrotonate decarboxylase Spea_2118 65 COG3971 COG3971, 2-keto-4-pentenoate hydratase Secondary metabolites biosynthesis, transport, and catabolism 157961774 Common - beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA Spea_1951 84 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 157962225 Common - transcriptional regulator, LysR family Spea_2404 192 COG0583 LysR, Transcriptional regulator Transcription 157961826 Common - malate synthase Spea_2005 52 None None None 157964001 Common - TAP domain protein Spea_4190 42 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 157963378 Common - hypothetical protein Spea_3564 18 None None None 157963364 Common - protein of unknown function DUF6 transmembrane Spea_3550 36 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 157962766 Common - sodium/glutamate symporter Spea_2948 51 COG0786 GltS, Na+/glutamate symporter Amino acid transport and metabolism 157960306 Common - cytochrome C biogenesis protein Spea_0477 69 COG3088 CcmH, Uncharacterized protein involved in biosynthesis of c-type cytochromes Posttranslational modification, protein turnover, chaperones 157961729 Common - hypothetical protein Spea_1906 3 None None None 157961922 Common - alpha-L-glutamate ligase, RimK family Spea_2101 143 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 157959839 Nonpathogen - hypothetical protein Spea_0009 1 COG3096 MukB, Uncharacterized protein involved in chromosome partitioning Cell division and chromosome partitioning 157962425 Common - Tetratricopeptide TPR_2 repeat protein Spea_2604 54 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 157964013 Common - ABC transporter related Spea_4202 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 157964026 Common - protein-export protein SecB Spea_4215 108 COG1952 SecB, Preprotein translocase subunit SecB Intracellular trafficking and secretion 157960760 Common - hypothetical protein Spea_0932 1 None None None 157961592 Common - hypothetical protein Spea_1768 47 COG3216 COG3216, Uncharacterized protein conserved in bacteria Function unknown 157963367 Common - hypothetical protein Spea_3553 9 None None None 157960768 Common - putative adenylyl cyclase CyaB Spea_0940 17 COG1437 CyaB, Adenylate cyclase, class 2 (thermophilic) Nucleotide transport and metabolism 157960958 Common - Ferrochelatase Spea_1130 161 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 157960216 Common - heavy metal efflux pump, CzcA family Spea_0387 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 157960390 Common - aspartate kinase Spea_0561 235 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 157962174 Common - electron transport complex, RnfABCDGE type, A subunit Spea_2353 76 COG4657 RnfA, Predicted NADH:ubiquinone oxidoreductase, subunit RnfA Energy production and conversion 157961726 Common - hypothetical protein Spea_1903 10 None None None 157964050 Common - ATP synthase F1, epsilon subunit Spea_4239 150 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 157963294 Common - Spermidine synthase Spea_3480 96 COG4262 COG4262, Predicted spermidine synthase with an N-terminal membrane domain General function prediction only 157963857 Nonpathogen - hypothetical protein Spea_4046 1 None None None 157962695 Common - outer membrane chaperone Skp (OmpH) Spea_2876 83 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 157963299 Common - Ion transport 2 domain protein Spea_3485 86 None None None 157959895 Common - flagellar hook-associated protein 3 Spea_0065 86 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 157963827 Common - transcription elongation factor GreB Spea_4016 196 COG0782 GreA, Transcription elongation factor Transcription 157961811 Common - peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin Spea_1990 25 COG1876 VanY, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 157960492 Common - sulfate adenylyltransferase, large subunit Spea_0664 249 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 157960332 Common - cytochrome c, putative Spea_0503 7 None None None 157962808 Common - Polyprenyl synthetase Spea_2990 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 157963575 Common - hypothetical protein Spea_3763 1 None None None 157960443 Nonpathogen - Sporulation domain protein Spea_0614 3 None None None 157962331 Common - nitroreductase Spea_2510 72 COG0778 NfnB, Nitroreductase Energy production and conversion 157961907 Common - DTW domain containing protein Spea_2086 34 COG3148 COG3148, Uncharacterized conserved protein Function unknown 157960255 Common - regulator of RpoD, Rsd/AlgQ Spea_0426 24 COG3160 Rsd, Regulator of sigma D Transcription 157962249 Common - NapD family protein Spea_2428 5 COG3062 NapD, Uncharacterized protein involved in formation of periplasmic nitrate reductase Inorganic ion transport and metabolism 157962801 Common - hydrolase of the alpha/beta-hydrolase fold-like protein Spea_2983 31 COG3571 COG3571, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 157962782 Common - Glutathione peroxidase Spea_2964 115 COG0386 BtuE, Glutathione peroxidase Posttranslational modification, protein turnover, chaperones 157962115 Common - protein of unknown function UPF0118 Spea_2294 111 COG0628 PerM, Predicted permease General function prediction only 157961081 Nonpathogen - hypothetical protein Spea_1253 1 None None None 157963081 Common - hypothetical protein Spea_3264 3 None None None 157963155 Common - Coproporphyrinogen dehydrogenase Spea_3339 203 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 157962204 Common - thiamine biosynthesis protein ThiC Spea_2383 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 157961427 Common - hypothetical protein Spea_1601 10 COG4399 COG4399, Uncharacterized protein conserved in bacteria Function unknown 157961612 Common - 2-oxoglutarate dehydrogenase, E1 subunit Spea_1788 147 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 157962879 Common - NusA antitermination factor Spea_3061 218 COG0195 NusA, Transcription elongation factor Transcription 157960161 Common - Mg chelatase, subunit ChlI Spea_0332 191 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 157962677 Common - hypothetical protein Spea_2858 38 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 157960006 Common - ribosomal protein L7/L12 Spea_0176 213 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 157960839 Common - PfkB domain protein Spea_1011 187 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 157963421 Common - Mammalian cell entry related domain protein Spea_3607 55 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 157962483 Common - competence protein ComEA helix-hairpin-helix repeat protein Spea_2662 106 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 157962212 Common - hypothetical protein Spea_2391 17 None None None 157963121 Common - 2-polyprenyl-6-methoxyphenol 4-hydroxylase Spea_3305 116 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 157963919 Common - pseudouridine synthase Rlu family protein, TIGR01621 Spea_4108 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 157963883 Common - NADH:flavin oxidoreductase/NADH oxidase Spea_4072 179 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 157963746 Common - regulatory protein TetR Spea_3935 1 None None None 157959869 Common - globin Spea_0039 66 COG2346 COG2346, Truncated hemoglobins General function prediction only 157962382 Common - porin Spea_2561 24 None None None 157963016 Common - DSBA oxidoreductase Spea_3199 75 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 157960411 Common - sodium/hydrogen exchanger Spea_0582 145 COG4651 RosB, Kef-type K+ transport system, predicted NAD-binding component Inorganic ion transport and metabolism 157962244 Common - Integrase catalytic region Spea_2423 142 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157960018 Common - ribosomal protein S19 Spea_0188 246 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 157960636 Common - transcriptional regulator, AsnC family Spea_0808 161 COG1522 Lrp, Transcriptional regulators Transcription 157963389 Common - phenylalanine/histidine ammonia-lyase Spea_3575 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 157959911 Common - flagellar assembly protein FliH Spea_0081 56 COG1317 FliH, Flagellar biosynthesis/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 157959987 Common - 3'(2'),5'-bisphosphate nucleotidase Spea_0157 199 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 157960684 Common - hypothetical protein Spea_0856 42 COG3610 COG3610, Uncharacterized conserved protein Function unknown 157961616 Common - hypothetical protein Spea_1792 3 None None None 157963433 Common - Phosphotransferase system, phosphocarrier protein HPr Spea_3621 147 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 157963685 Common - aminoglycoside phosphotransferase Spea_3874 19 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 157963431 Common - sigma 54 modulation protein/ribosomal protein S30EA Spea_3617 127 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 157963445 Common - hypothetical protein Spea_3633 118 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 157961880 Common - Domain of unknown function DUF1863 Spea_2059 14 None None None 157959958 Common - molybdenum cofactor synthesis domain Spea_0128 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 157961242 Common - polysaccharide biosynthesis protein CapD Spea_1416 140 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 157960269 Common - formate dehydrogenase, gamma subunit Spea_0440 64 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 157961877 Common - phosphoglucomutase, alpha-D-glucose phosphate-specific Spea_2056 185 COG0033 Pgm, Phosphoglucomutase Carbohydrate transport and metabolism 157962038 Common - cytochrome c oxidase, cbb3-type, subunit III Spea_2217 82 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 157963613 Common - Porphobilinogen synthase Spea_3801 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 157960884 Common - Oxidoreductase FAD-binding domain protein Spea_1056 146 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 157962830 Nonpathogen - Carbohydrate-selective porin OprB Spea_3012 7 COG3659 OprB, Carbohydrate-selective porin Cell envelope biogenesis, outer membrane 157959951 Common - hypothetical protein Spea_0121 33 COG5099 COG5099, RNA-binding protein of the Puf family, translational repressor Translation, ribosomal structure and biogenesis 157960800 Common - Peptidoglycan-binding domain 1 protein Spea_0972 73 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 157960477 Common - MltA-interacting MipA family protein Spea_0649 20 COG3713 OmpV, Outer membrane protein V Cell envelope biogenesis, outer membrane 157962632 Common - Nitrite reductase (cytochrome; ammonia-forming) Spea_2812 40 COG3303 NrfA, Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit Inorganic ion transport and metabolism 157961959 Common - protein of unknown function DUF35 Spea_2138 45 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 157959965 Common - lipoprotein, putative Spea_0135 4 None None None 157961229 Nonpathogen - hypothetical protein Spea_1402 3 None None None 157961962 Common - lipid-transfer protein Spea_2141 89 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 157960906 Common - protein of unknown function DUF328 Spea_1078 89 COG3022 COG3022, Uncharacterized protein conserved in bacteria Function unknown 157962866 Common - deoxyribose-phosphate aldolase Spea_3048 137 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 157961435 Common - alanine racemase domain protein Spea_1609 54 COG3616 COG3616, Predicted amino acid aldolase or racemase Amino acid transport and metabolism 157961402 Common - NADH:ubiquinone oxidoreductase, subunit D Spea_1576 76 COG1347 NqrD, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD Energy production and conversion 157962612 Common - acyl-CoA thioesterase II Spea_2791 77 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 157961088 Common - phage transcriptional regulator, AlpA Spea_1260 51 COG3311 AlpA, Predicted transcriptional regulator Transcription 157959903 Common - flagellar hook capping protein Spea_0073 113 COG1843 FlgD, Flagellar hook capping protein Cell motility and secretion 157962116 Common - Glutathione synthase Spea_2295 2 None None None 157961345 Common - N-acylglucosamine-6-phosphate 2-epimerase Spea_1519 43 COG3010 NanE, Putative N-acetylmannosamine-6-phosphate epimerase Carbohydrate transport and metabolism 157961141 Common - inosine-5'-monophosphate dehydrogenase Spea_1313 233 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 157962608 Common - OmpW family protein Spea_2787 69 COG3047 OmpW, Outer membrane protein W Cell envelope biogenesis, outer membrane 157961311 Common - RNA methyltransferase, TrmH family, group 1 Spea_1485 171 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 157961077 Common - transcriptional regulator, AraC family Spea_1249 89 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 157962983 Common - pseudouridine synthase, RluA family Spea_3166 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 157960258 Common - short-chain dehydrogenase/reductase SDR Spea_0429 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 157961866 Common - multiple antibiotic resistance (MarC)-related protein Spea_2045 158 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 157961643 Common - curli production assembly/transport component CsgF precursor Spea_1819 13 None None None 157960867 Common - DNA repair protein RecO Spea_1039 60 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 157962532 Common - hypothetical protein Spea_2711 2 None None None 157963632 Common - hypothetical protein Spea_3821 1 None None None 157960204 Common - Frataxin family protein Spea_0375 44 COG1965 CyaY, Protein implicated in iron transport, frataxin homolog Inorganic ion transport and metabolism 157962257 Common - surface antigen (D15) Spea_2436 122 COG0729 COG0729, Outer membrane protein Cell envelope biogenesis, outer membrane 157963025 Common - transcriptional repressor, CopY family Spea_3208 43 COG3682 COG3682, Predicted transcriptional regulator Transcription 157961850 Common - hypothetical protein Spea_2029 5 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 157961384 Common - MATE efflux family protein Spea_1558 109 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 157961453 Nonpathogen - hypothetical protein Spea_1627 1 COG3459 COG3459, Cellobiose phosphorylase Carbohydrate transport and metabolism 157962087 Common - hypothetical protein Spea_2266 16 None None None 157962121 Common - peptidase S8 and S53 subtilisin kexin sedolisin Spea_2300 98 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 157960221 Common - fumarate reductase respiratory complex transmembrane subunit Spea_0392 10 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 157963147 Common - periplasmic binding protein Spea_3331 120 COG4558 ChuT, ABC-type hemin transport system, periplasmic component Inorganic ion transport and metabolism 157963213 Common - ABC transporter related Spea_3399 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 157962296 Common - hypothetical protein Spea_2475 7 None None None 157963759 Common - peptidase M16 domain protein Spea_3948 202 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 157961053 Common - potassium efflux system protein Spea_1225 204 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 157961816 Common - Phosphotransferase system, phosphocarrier protein HPr Spea_1995 99 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 157960126 Common - hypothetical protein Spea_0297 9 None None None 157962268 Common - ribonuclease D Spea_2447 118 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 157963779 Common - hypothetical protein Spea_3968 1 None None None 157963548 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Spea_3736 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 157964069 Common - protein of unknown function DUF37 Spea_4258 185 COG0759 COG0759, Uncharacterized conserved protein Function unknown 157963199 Common - methionine synthase Spea_3384 179 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 157960217 Common - Leucyl aminopeptidase Spea_0388 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 157960937 Common - tRNA (guanine-N(7)-)-methyltransferase Spea_1109 178 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 157963319 Common - alpha/beta hydrolase fold Spea_3505 71 COG0429 COG0429, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 157963470 Common - multidrug resistance efflux pump Spea_3658 107 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 157960827 Common - hypothetical protein Spea_0999 19 None None None 157960940 Common - hypothetical protein Spea_1112 8 None None None 157963039 Common - hypothetical protein Spea_3222 24 COG3907 COG3907, PAP2 (acid phosphatase) superfamily protein General function prediction only 157961442 Common - hypothetical protein Spea_1616 33 COG3170 FimV, Tfp pilus assembly protein FimV Cell motility and secretion / Intracellular trafficking and secretion 157963170 Common - UspA domain protein Spea_3354 88 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 157963594 Common - heat shock protein HslVU, ATPase subunit HslU Spea_3782 211 COG1220 HslU, ATP-dependent protease HslVU (ClpYQ), ATPase subunit Posttranslational modification, protein turnover, chaperones 157962338 Common - OmpA/MotB domain protein Spea_2517 126 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 157961061 Common - hypothetical protein Spea_1233 14 None None None 157959991 Common - selenide, water dikinase Spea_0161 138 COG0709 SelD, Selenophosphate synthase Amino acid transport and metabolism 157960505 Common - Na+/H+ antiporter NhaC Spea_0677 73 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 157960316 Common - ABC transporter related Spea_0487 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 157960171 Common - transcriptional regulator, LysR family Spea_0342 97 COG0583 LysR, Transcriptional regulator Transcription 157961119 Common - putative signal transduction protein Spea_1291 30 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 157963817 Common - protoheme IX farnesyltransferase Spea_4006 167 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 157960516 Common - hypoxanthine phosphoribosyltransferase Spea_0688 151 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 157962006 Common - Methyltransferase type 11 Spea_2185 44 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 157960658 Common - histidine kinase Spea_0830 140 COG3850 NarQ, Signal transduction histidine kinase, nitrate/nitrite-specific Signal transduction mechanisms 157963698 Common - phospholipid/glycerol acyltransferase Spea_3887 60 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 157960368 Common - outer membrane efflux family protein, putative Spea_0539 15 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 157963810 Common - Cytochrome c oxidase subunit II Spea_3999 160 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 157961902 Common - acyl-CoA dehydrogenase domain protein Spea_2081 152 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157962517 Common - hypothetical protein Spea_2696 8 None None None 157963301 Common - protein of unknown function DUF47 Spea_3487 39 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 157963178 Common - protein of unknown function DUF214 Spea_3363 102 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 157963699 Common - acyl carrier protein, putative Spea_3888 50 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 157963767 Common - drug resistance transporter, Bcr/CflA subfamily Spea_3956 226 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 157963891 Common - diaminopropionate ammonia-lyase Spea_4080 127 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 157960095 Common - transcriptional regulator, LysR family Spea_0266 182 COG0583 LysR, Transcriptional regulator Transcription 157960651 Common - aminopeptidase N Spea_0823 168 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 157961835 Nonpathogen - hypothetical protein Spea_2014 1 None None None 157962885 Common - ATP-dependent metalloprotease FtsH Spea_3067 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 157961268 Common - protein of unknown function DUF218 Spea_1442 57 COG1434 COG1434, Uncharacterized conserved protein Function unknown 157962750 Common - transposase IS116/IS110/IS902 family protein Spea_2932 63 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 157961330 Common - hypothetical protein Spea_1504 14 COG3219 COG3219, Uncharacterized protein conserved in bacteria Function unknown 157961044 Common - secretion protein HlyD family protein Spea_1216 143 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 157963324 Common - hypothetical protein Spea_3510 2 COG3212 COG3212, Predicted membrane protein Function unknown 157963041 Common - putative outer membrane adhesin like proteiin Spea_3224 61 None None None 157959992 Common - Stearoyl-CoA 9-desaturase Spea_0162 62 COG1398 OLE1, Fatty-acid desaturase Lipid metabolism 157960725 Common - protein of unknown function DUF52 Spea_0897 67 COG1355 COG1355, Predicted dioxygenase General function prediction only 157960288 Common - protein of unknown function DUF465 Spea_0459 29 COG2841 COG2841, Uncharacterized protein conserved in bacteria Function unknown 157960680 Common - ribosomal protein L21 Spea_0852 215 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 157960745 Common - peptidase S8 and S53 subtilisin kexin sedolisin Spea_0917 123 None None None 157960821 Common - protein of unknown function UPF0075 Spea_0993 120 COG2377 COG2377, Predicted molecular chaperone distantly related to HSP70-fold metalloproteases Posttranslational modification, protein turnover, chaperones 157963171 Common - UspA domain protein Spea_3355 63 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 157960142 Nonpathogen - protein of unknown function DUF904 Spea_0313 1 None None None 157960757 Common - hypothetical protein Spea_0929 19 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 157963201 Nonpathogen - hypothetical protein Spea_3386 1 None None None 157963803 Common - secretion protein HlyD family protein Spea_3992 122 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 157961520 Common - hypothetical protein Spea_1695 53 COG4327 COG4327, Predicted membrane protein Function unknown 157963516 Common - SNF2-related protein Spea_3704 135 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 157960771 Common - transcriptional regulator, XRE family Spea_0943 95 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 157962349 Common - 17 kDa surface antigen Spea_2528 9 COG3133 SlyB, Outer membrane lipoprotein Cell envelope biogenesis, outer membrane 157962963 Common - nicotinate (nicotinamide) nucleotide adenylyltransferase Spea_3146 188 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 157961437 Common - GCN5-related N-acetyltransferase Spea_1611 30 COG0456 RimI, Acetyltransferases General function prediction only 157963446 Common - major facilitator superfamily MFS_1 Spea_3634 70 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 157960975 Nonpathogen - hypothetical protein Spea_1147 2 None None None 157961404 Common - NADH:ubiquinone oxidoreductase, subunit F Spea_1578 161 COG2871 NqrF, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF Energy production and conversion 157962028 Common - hypothetical protein Spea_2207 2 None None None 157960245 Common - N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD Spea_0416 108 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 157963612 Common - periplasmic/7TM domain sensor diguanylate cyclase Spea_3800 179 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 157960323 Common - protein of unknown function DUF1568 Spea_0494 10 None None None 157960260 Common - phosphoribosylamine--glycine ligase Spea_0431 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 157963633 Common - glycerol kinase Spea_3822 179 COG0554 GlpK, Glycerol kinase Energy production and conversion 157962576 Common - Lysine exporter protein (LYSE/YGGA) Spea_2755 100 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 157962962 Common - DNA polymerase III, delta subunit Spea_3145 66 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 157962067 Common - 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) Spea_2246 156 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 157962397 Common - uracil phosphoribosyltransferase Spea_2576 164 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 157962237 Common - ATPase associated with various cellular activities AAA_3 Spea_2416 174 COG0714 COG0714, MoxR-like ATPases General function prediction only 157962123 Common - hypothetical protein Spea_2302 4 None None None 157960643 Common - Lysine exporter protein (LYSE/YGGA) Spea_0815 89 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 157960879 Common - tRNA (guanine-N1)-methyltransferase Spea_1051 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 157961606 Common - citrate synthase I Spea_1782 2 COG0372 GltA, Citrate synthase Energy production and conversion 157960128 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Spea_0299 3 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 157960426 Common - rRNA (guanine-N(2)-)-methyltransferase Spea_0597 105 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 157962410 Common - modification methylase, HemK family Spea_2589 218 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 157962863 Common - purine nucleoside phosphorylase Spea_3045 94 COG0813 DeoD, Purine-nucleoside phosphorylase Nucleotide transport and metabolism 157963776 Common - Polysulphide reductase NrfD Spea_3965 28 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 157962708 Nonpathogen - hypothetical protein Spea_2889 2 None None None 157963584 Common - conserved hypothetical biogenesis protein MshI Spea_3772 14 None None None 157963661 Common - purine or other phosphorylase family 1 Spea_3850 65 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 157961178 Common - flagellar hook-associated protein 3 Spea_1350 89 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 157962701 Common - ribosome recycling factor Spea_2882 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 157961352 Common - heat shock protein Hsp90 Spea_1526 150 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 157962691 Common - lipid-A-disaccharide synthase Spea_2872 139 COG0763 LpxB, Lipid A disaccharide synthetase Cell envelope biogenesis, outer membrane 157962119 Common - histidine kinase Spea_2298 147 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 157959995 Common - glutamate racemase Spea_0165 190 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 157961148 Common - cyd operon protein YbgT Spea_1320 22 COG4890 COG4890, Predicted outer membrane lipoprotein Function unknown 157961685 Common - RarD protein, DMT superfamily transporter Spea_1861 109 COG2962 RarD, Predicted permeases General function prediction only 157960358 Common - putative plasmid transfer protein Spea_0529 11 None None None 157963567 Common - PA14-related domain protein Spea_3755 20 None None None 157960438 Nonpathogen - Sporulation domain protein Spea_0609 2 None None None 157963643 Common - RarD protein, DMT superfamily transporter Spea_3832 100 COG2962 RarD, Predicted permeases General function prediction only 157962168 Common - Pyridoxal-5'-phosphate-dependent protein beta subunit Spea_2347 218 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 157962450 Common - integron integrase Spea_2629 31 None None None 157962597 Common - short-chain dehydrogenase/reductase SDR Spea_2776 2 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157961716 Common - type III restriction protein res subunit Spea_1893 46 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 157959988 Common - GCN5-related N-acetyltransferase Spea_0158 21 COG0456 RimI, Acetyltransferases General function prediction only 157963084 Common - BAX protein Spea_3268 31 COG2992 Bax, Uncharacterized FlgJ-related protein General function prediction only 157962188 Common - diguanylate cyclase Spea_2367 191 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157962197 Common - conserved hypothetical methyl-accepting chemotaxis protein Spea_2376 1 None None None 157961273 Common - UTP-glucose-1-phosphate uridylyltransferase Spea_1447 229 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 157959940 Common - lipopolysaccharide kinase Spea_0110 20 COG0478 COG0478, RIO-like serine/threonine protein kinase fused to N-terminal HTH domain Signal transduction mechanisms 157963898 Common - ABC transporter related Spea_4087 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 157963308 Common - ABC transporter CydDC cysteine exporter (CydDC-E) family permease/ATP-binding protein CydD Spea_3494 249 COG4988 CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 157963408 Common - ribosomal protein S9 Spea_3594 249 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 157962381 Common - glutaredoxin, GrxA family Spea_2560 36 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 157963913 Nonpathogen - hypothetical protein Spea_4102 1 None None None 157961416 Common - anthranilate synthase component I Spea_1590 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 157960311 Common - hypothetical protein Spea_0482 14 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 157960203 Common - putative adenylate cyclase Spea_0374 25 COG3072 CyaA, Adenylate cyclase Nucleotide transport and metabolism 157960057 Common - acetylglutamate kinase Spea_0228 213 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 157960712 Common - UspA domain protein Spea_0884 29 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 157960526 Common - transcriptional regulator, TraR/DksA family Spea_0698 144 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 157962319 Common - ribosomal protein L32 Spea_2498 65 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 157963351 Common - HflC protein Spea_3537 207 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 157960184 Common - protein of unknown function DUF417 Spea_0355 17 COG3059 COG3059, Predicted membrane protein Function unknown 157963392 Common - transcriptional regulator, LuxR family Spea_3578 1 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 157960277 Common - transcriptional regulator, LysR family Spea_0448 153 COG0583 LysR, Transcriptional regulator Transcription 157963918 Common - pantetheine-phosphate adenylyltransferase Spea_4107 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 157962485 Common - Cystathionine gamma-synthase Spea_2664 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 157962995 Common - hypothetical protein Spea_3178 6 COG2357 COG2357, Uncharacterized protein conserved in bacteria Function unknown 157963094 Nonpathogen - hypothetical protein Spea_3278 1 None None None 157963925 Common - molybdate ABC transporter, inner membrane subunit Spea_4114 221 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 157963515 Common - PhoH family protein Spea_3703 198 COG1875 COG1875, Predicted ATPase related to phosphate starvation-inducible protein PhoH Signal transduction mechanisms 157963479 Common - metal dependent phosphohydrolase Spea_3667 105 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 157962154 Common - 6-phosphogluconate dehydratase Spea_2333 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 157961868 Common - metal dependent phosphohydrolase Spea_2047 27 COG1896 COG1896, Predicted hydrolases of HD superfamily General function prediction only 157963343 Common - transport system permease protein Spea_3529 192 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 157963755 Common - Radical SAM domain protein Spea_3944 76 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 157960678 Common - malate dehydrogenase, NAD-dependent Spea_0850 190 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 157960226 Common - transcription termination factor Rho Spea_0397 201 COG1158 Rho, Transcription termination factor Transcription 157960444 Common - hypothetical protein Spea_0615 7 None None None 157961035 Common - peptidase M16 domain protein Spea_1207 195 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 157963603 Common - Arginase/agmatinase/formiminoglutamase Spea_3791 28 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 157960075 Common - tryptophanyl-tRNA synthetase Spea_0246 226 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 157962181 Common - lactoylglutathione lyase Spea_2360 123 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 157962124 Common - hypothetical protein Spea_2303 11 None None None 157962194 Common - peptidase M3A and M3B, thimet/oligopeptidase F Spea_2373 1 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 157962310 Common - 6-phosphogluconate dehydrogenase NAD-binding Spea_2489 193 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 157963558 Common - outer membrane efflux protein Spea_3746 39 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 157963282 Common - hypothetical protein Spea_3468 6 None None None 157961531 Common - FAD dependent oxidoreductase Spea_1706 133 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 157963481 Nonpathogen - hypothetical protein Spea_3669 1 None None None 157961637 Common - nitrite transporter Spea_1813 113 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 157960094 Common - diguanylate cyclase Spea_0265 179 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157961529 Common - dihydrodipicolinate synthase Spea_1704 20 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 157961630 Common - cytochrome c3 Spea_1806 1 None None None 157962060 Common - Endonuclease/exonuclease/phosphatase Spea_2239 31 COG3021 COG3021, Uncharacterized protein conserved in bacteria Function unknown 157962432 Common - acriflavin resistance protein Spea_2611 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 157961465 Common - YCII-related Spea_1639 68 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 157960564 Common - Succinylglutamate desuccinylase/aspartoacylase Spea_0736 29 COG3608 COG3608, Predicted deacylase General function prediction only 157963116 Nonpathogen - hypothetical protein Spea_3300 1 None None None 157960280 Common - GCN5-related N-acetyltransferase Spea_0451 87 COG2153 ElaA, Predicted acyltransferase General function prediction only 157962078 Common - peptidase M14 carboxypeptidase A Spea_2257 34 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 157963372 Common - DNA topoisomerase IV, B subunit Spea_3558 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 157960914 Common - hydroxymethylbutenyl pyrophosphate reductase Spea_1086 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 157961205 Common - Cobyrinic acid ac-diamide synthase Spea_1377 168 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 157962563 Common - phosphate uptake regulator, PhoU Spea_2742 187 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 157963245 Common - protein of unknown function DUF331 Spea_3431 11 COG3036 COG3036, Uncharacterized protein conserved in bacteria Function unknown 157962959 Common - protein of unknown function DUF1451 Spea_3142 20 None None None 157961138 Nonpathogen - hypothetical protein Spea_1310 1 None None None 157962953 Common - hypothetical protein Spea_3136 1 None None None 157961064 Nonpathogen - putative lipoprotein Spea_1236 3 None None None 157962835 Common - pseudouridine synthase Spea_3017 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 157963287 Nonpathogen - hypothetical protein Spea_3473 1 None None None 157960955 Common - alanine racemase domain protein Spea_1127 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 157963225 Common - Choloylglycine hydrolase Spea_3411 44 COG3049 COG3049, Penicillin V acylase and related amidases Cell envelope biogenesis, outer membrane 157961023 Common - recA protein Spea_1195 214 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 157960748 Common - peptidase M24 Spea_0920 173 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 157961320 Common - transposase Spea_1494 9 None None None 157960694 Common - aminoglycoside phosphotransferase Spea_0866 91 COG3178 COG3178, Predicted phosphotransferase related to Ser/Thr protein kinases General function prediction only 157961136 Common - Pyrrolo-quinoline quinone Spea_1308 117 COG1520 COG1520, FOG: WD40-like repeat Function unknown 157962682 Common - Nitrilase Spea_2863 117 COG0388 COG0388, Predicted amidohydrolase General function prediction only 157962646 Common - hypothetical protein Spea_2826 17 COG3864 COG3864, Uncharacterized protein conserved in bacteria Function unknown 157962928 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Spea_3111 191 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 157963668 Common - choline/carnitine/betaine transporter Spea_3857 95 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 157963262 Common - hypothetical protein Spea_3448 3 None None None 157962364 Common - Glu/Leu/Phe/Val dehydrogenase dimerisation region Spea_2543 168 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 157963107 Common - hypothetical protein Spea_3291 2 None None None 157963208 Common - TM2 domain containing protein? Spea_3393 17 COG2314 XynA, Predicted membrane protein Function unknown 157962791 Common - Tetratricopeptide domain protein Spea_2973 31 None None None 157963154 Common - transmembrane pair domain protein Spea_3338 41 COG4125 COG4125, Predicted membrane protein Function unknown 157960635 Common - single-stranded-DNA-specific exonuclease RecJ Spea_0807 200 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 157959873 Common - protein of unknown function DUF115 Spea_0043 15 COG2604 COG2604, Uncharacterized protein conserved in bacteria Function unknown 157960403 Common - putative cation efflux protein Spea_0574 13 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 157960195 Common - type I secretion membrane fusion protein, HlyD family Spea_0366 119 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 157963675 Common - cytoplasmic chaperone TorD family protein Spea_3864 21 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 157962494 Common - binding-protein-dependent transport systems inner membrane component Spea_2673 212 COG4171 SapC, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 157963068 Common - sodium/glutamate symporter Spea_3251 55 COG0786 GltS, Na+/glutamate symporter Amino acid transport and metabolism 157960625 Common - Radical SAM domain protein Spea_0797 14 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 157963539 Nonpathogen - hypothetical protein Spea_3727 1 None None None 157960043 Common - heme exporter protein CcmB Spea_0214 82 COG2386 CcmB, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 157962303 Common - protein of unknown function DUF480 Spea_2482 41 COG3132 COG3132, Uncharacterized protein conserved in bacteria Function unknown 157961640 Common - Curlin associated repeat protein Spea_1816 18 None None None 157961958 Common - short-chain dehydrogenase/reductase SDR Spea_2137 234 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157960847 Common - putative adenylate/guanylate cyclase Spea_1019 7 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 157960560 Common - peptidase S9B dipeptidylpeptidase IV domain protein Spea_0732 110 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 157960795 Common - putative undecaprenol kinase Spea_0967 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 157963595 Common - protein of unknown function DUF971 Spea_3783 51 COG3536 COG3536, Uncharacterized protein conserved in bacteria Function unknown 157961004 Common - response regulator receiver protein Spea_1176 95 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 157963932 Common - Electron-transferring-flavoprotein dehydrogenase Spea_4121 106 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 157962457 Common - inner membrane lipoprotein Spea_2636 3 None None None 157962555 Common - AMP-dependent synthetase and ligase Spea_2734 197 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 157962633 Nonpathogen - hypothetical protein Spea_2813 2 None None None 157960340 Common - ABC transporter related Spea_0511 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 157960567 Common - hypothetical protein Spea_0739 1 None None None 157961123 Common - hypothetical protein Spea_1295 78 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 157962817 Common - TonB family protein Spea_2999 7 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 157960846 Common - transposase Spea_1018 9 None None None 157963997 Common - AMP-dependent synthetase and ligase Spea_4186 212 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 157963782 Common - 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase Spea_3971 117 COG1165 MenD, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Coenzyme metabolism 157962581 Common - hypothetical protein Spea_2760 15 None None None 157962285 Common - Phosphoribosylaminoimidazole-succinocarboxamide synthase Spea_2464 122 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 157963736 Common - iron-containing alcohol dehydrogenase Spea_3925 168 COG1979 COG1979, Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family Energy production and conversion 157961536 Common - peptidase M24 Spea_1711 220 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 157960736 Common - response regulator receiver modulated diguanylate phosphodiesterase Spea_0908 184 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 157961550 Common - beta-lactamase domain protein Spea_1726 43 COG2015 COG2015, Alkyl sulfatase and related hydrolases Secondary metabolites biosynthesis, transport, and catabolism 157960521 Common - pantoate--beta-alanine ligase Spea_0693 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 157963545 Common - hypothetical protein Spea_3733 1 None None None 157963269 Nonpathogen - hypothetical protein Spea_3455 2 None None None 157960050 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Spea_0221 140 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 157962594 Common - transcriptional regulator, MerR family Spea_2773 142 COG0789 SoxR, Predicted transcriptional regulators Transcription 157962662 Common - TonB-dependent receptor Spea_2843 107 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 157961111 Common - cyclase/dehydrase Spea_1283 102 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 157963964 Common - hypothetical protein Spea_4153 2 COG4531 ZnuA, ABC-type Zn2+ transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 157963506 Common - transcriptional regulator, LysR family Spea_3694 168 COG0583 LysR, Transcriptional regulator Transcription 157960159 Common - phospholipid/glycerol acyltransferase Spea_0330 30 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 157959852 Common - Protoporphyrinogen oxidase Spea_0022 33 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 157962324 Common - pseudouridine synthase, RluA family Spea_2503 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 157960026 Common - ribosomal protein L5 Spea_0196 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 157962650 Nonpathogen - hypothetical protein Spea_2830 1 None None None 157961783 Common - SpoVR family protein Spea_1960 71 COG2719 SpoVR, Uncharacterized conserved protein Function unknown 157960919 Common - methylation site containing protein Spea_1091 67 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 157960897 Nonpathogen - hypothetical protein Spea_1069 1 None None None 157963901 Common - hypothetical protein Spea_4090 103 COG1738 COG1738, Uncharacterized conserved protein Function unknown 157963384 Common - TIM-barrel protein, yjbN family Spea_3570 208 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 157961976 Common - coenzyme A transferase Spea_2155 36 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 157963582 Common - MSHA biogenesis protein MshJ Spea_3770 15 None None None 157961387 Common - transcriptional regulator, TetR family Spea_1561 52 COG1309 AcrR, Transcriptional regulator Transcription 157963627 Common - UDP-N-acetylmuramyl-tripeptide synthetase Spea_3816 211 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 157963143 Common - TonB-dependent heme/hemoglobin receptor family protein Spea_3327 130 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 157960356 Common - Glutamate dehydrogenase (NADP(+)) Spea_0527 172 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 157961512 Common - chromosome segregation protein SMC Spea_1687 185 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 157962809 Common - deoxyxylulose-5-phosphate synthase Spea_2991 219 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 157959883 Common - hypothetical protein Spea_0053 2 None None None 157962921 Common - quorum-sensing autoinducer 2 (AI-2), LuxS Spea_3104 55 COG1854 LuxS, LuxS protein involved in autoinducer AI2 synthesis Signal transduction mechanisms 157960881 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Spea_1053 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 157959976 Common - general secretion pathway protein F Spea_0146 142 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 157962584 Common - nucleoside transporter Spea_2763 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 157961503 Common - C4-dicarboxylate anaerobic carrier Spea_1678 38 COG1288 COG1288, Predicted membrane protein Function unknown 157962810 Common - GrpE protein Spea_2992 230 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 157961943 Common - major facilitator superfamily MFS_1 Spea_2122 206 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 157960432 Common - hypothetical protein Spea_0603 7 COG2039 Pcp, Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase) Posttranslational modification, protein turnover, chaperones 157962600 Common - Enoyl-CoA hydratase/isomerase Spea_2779 123 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 157960990 Common - riboflavin biosynthesis protein RibD Spea_1162 226 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 157964005 Common - transcriptional regulator, AraC family Spea_4194 129 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 157963055 Common - PepSY-associated TM helix domain protein Spea_3238 5 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 157961589 Common - 37kDa nucleoid-associated protein Spea_1765 31 COG3081 COG3081, Nucleoid-associated protein General function prediction only 157962541 Common - basic membrane lipoprotein Spea_2720 93 COG1744 Med, Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein General function prediction only 157960984 Common - efflux transporter, RND family, MFP subunit Spea_1156 166 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157964045 Common - glucosamine--fructose-6-phosphate aminotransferase, isomerizing Spea_4234 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 157961010 Common - (p)ppGpp synthetase I, SpoT/RelA Spea_1182 205 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 157959894 Common - hypothetical protein Spea_0064 8 None None None 157961180 Common - flagellin domain protein Spea_1352 140 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 157959841 Common - hypothetical protein Spea_0011 13 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 157960925 Common - TonB-dependent receptor Spea_1097 37 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 157964035 Common - hypothetical protein Spea_4224 1 None None None 157960872 Common - hypothetical protein Spea_1044 9 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 157961666 Common - Ion transport 2 domain protein Spea_1842 22 None None None 157960349 Common - oxidoreductase FAD/NAD(P)-binding domain protein Spea_0520 86 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 157960582 Common - formate dehydrogenase, alpha subunit Spea_0754 233 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 157961572 Common - ABC transporter related Spea_1748 249 COG3638 COG3638, ABC-type phosphate/phosphonate transport system, ATPase component Inorganic ion transport and metabolism 157962056 Common - alanine dehydrogenase Spea_2235 167 COG0686 Ald, Alanine dehydrogenase Amino acid transport and metabolism 157963789 Common - protein of unknown function DUF214 Spea_3978 116 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 157962211 Common - Methylated-DNA-(protein)-cysteine S-methyltransferase DNA binding Spea_2390 71 COG3695 COG3695, Predicted methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 157960861 Common - sigma E regulatory protein, MucB/RseB Spea_1033 48 COG3026 RseB, Negative regulator of sigma E activity Signal transduction mechanisms 157960450 Common - ferredoxin-type protein, NapH/MauN family Spea_0621 76 COG0348 NapH, Polyferredoxin Energy production and conversion 157962952 Common - Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family Spea_3135 131 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 157962743 Common - hypothetical protein Spea_2925 5 COG5620 COG5620, Uncharacterized conserved protein Function unknown 157961851 Common - hydrogenase expression/formation protein Spea_2030 64 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 157962685 Common - hypothetical protein Spea_2866 13 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 157961329 Common - protein of unknown function DUF692 Spea_1503 62 COG3220 COG3220, Uncharacterized protein conserved in bacteria Function unknown 157962416 Nonpathogen - hypothetical protein Spea_2595 1 None None None 157962147 Common - sulfatase Spea_2326 61 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 157961675 Common - Aldose 1-epimerase Spea_1851 54 COG0676 COG0676, Uncharacterized enzymes related to aldose 1-epimerase Carbohydrate transport and metabolism 157960731 Common - DEAD/DEAH box helicase domain protein Spea_0903 234 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 157961422 Nonpathogen - hypothetical protein Spea_1596 1 None None None 157962854 Common - sulfatase Spea_3036 51 COG3083 COG3083, Predicted hydrolase of alkaline phosphatase superfamily General function prediction only 157959950 Common - protein of unknown function DUF692 Spea_0120 62 COG3220 COG3220, Uncharacterized protein conserved in bacteria Function unknown 157961237 Nonpathogen - hypothetical protein Spea_1410 1 None None None 157963946 Common - formate dehydrogenase, gamma subunit Spea_4135 62 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 157963638 Common - 3-isopropylmalate dehydrogenase Spea_3827 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 157962201 Common - thiamine biosynthesis protein ThiS Spea_2380 4 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 157962630 Common - histidine kinase Spea_2810 179 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157961618 Common - ferredoxin-dependent glutamate synthase Spea_1794 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 157959890 Common - hypothetical protein Spea_0060 1 None None None 157963640 Common - response regulator receiver protein Spea_3829 1 None None None 157964033 Common - protein of unknown function UPF0153 Spea_4222 35 None None None 157963741 Common - nitrogen metabolism transcriptional regulator, NtrC, Fis Family Spea_3930 214 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 157960214 Common - outer membrane efflux protein Spea_0385 39 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 157963713 Common - 3-oxoacyl-(acyl-carrier-protein) reductase, putative Spea_3902 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157961043 Common - peptidase S41 Spea_1215 87 COG4946 COG4946, Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system Function unknown 157960475 Common - hypothetical protein Spea_0647 1 None None None 157960966 Common - TonB-dependent receptor plug Spea_1138 114 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 157963329 Common - Arginine N-succinyltransferase Spea_3515 37 COG3138 AstA, Arginine/ornithine N-succinyltransferase beta subunit Amino acid transport and metabolism 157963904 Common - two component, sigma54 specific, transcriptional regulator, Fis family Spea_4093 214 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 157963617 Common - UDP-3-0-acyl N-acetylglucosamine deacetylase Spea_3806 139 COG0774 LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase Cell envelope biogenesis, outer membrane 157962089 Common - MATE efflux family protein Spea_2268 167 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 157960945 Common - C4-dicarboxylate transporter/malic acid transport protein Spea_1117 40 COG1275 TehA, Tellurite resistance protein and related permeases Inorganic ion transport and metabolism 157961886 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Spea_2065 181 COG0546 Gph, Predicted phosphatases General function prediction only 157960418 Common - porin Gram-negative type Spea_0589 25 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 157962013 Common - efflux transporter, RND family, MFP subunit Spea_2192 148 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157962870 Common - hypothetical protein Spea_3052 1 None None None 157963138 Common - AMP-dependent synthetase and ligase Spea_3322 222 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 157962157 Common - transcriptional regulator, RpiR family Spea_2336 96 COG1737 RpiR, Transcriptional regulators Transcription 157963020 Common - transcriptional regulator, LysR family Spea_3203 186 COG0583 LysR, Transcriptional regulator Transcription 157963687 Common - hypothetical protein Spea_3876 2 None None None 157960016 Common - Ribosomal protein L25/L23 Spea_0186 215 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 157959956 Common - ankyrin Spea_0126 51 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 157959867 Common - SUA5/yciO/yrdC domain Spea_0037 238 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 157961251 Common - glycosyl transferase family 2 Spea_1425 200 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 157961474 Common - pseudouridine synthase Spea_1648 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 157962387 Common - Biopolymer transport TolR Spea_2566 138 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 157963162 Common - TMAO reductase system periplasmic TorT Spea_3346 17 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 157960498 Common - hypothetical protein Spea_0670 18 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 157962213 Common - glutamine amidotransferase class-II Spea_2392 73 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 157962322 Common - diguanylate cyclase with PAS/PAC sensor Spea_2501 179 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157963552 Common - peptidase U62 modulator of DNA gyrase Spea_3740 157 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 157960753 Common - Ig domain protein group 2 domain protein Spea_0925 25 None None None 157963593 Common - 20S proteasome A and B subunits Spea_3781 149 COG5405 HslV, ATP-dependent protease HslVU (ClpYQ), peptidase subunit Posttranslational modification, protein turnover, chaperones 157964007 Common - methyl-accepting chemotaxis sensory transducer Spea_4196 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157963988 Nonpathogen - hypothetical protein Spea_4177 1 None None None 157962032 Common - integrase family protein Spea_2211 41 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 157963560 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Spea_3748 203 COG0388 COG0388, Predicted amidohydrolase General function prediction only 157960934 Common - Integrase catalytic region Spea_1106 142 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157963493 Common - protein of unknown function DUF1568 Spea_3681 22 None None None 157961898 Common - orotidine 5'-phosphate decarboxylase Spea_2077 169 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 157962294 Common - protein of unknown function DUF785 Spea_2473 30 COG4067 COG4067, Uncharacterized protein conserved in archaea Posttranslational modification, protein turnover, chaperones 157961478 Common - protein of unknown function DUF437 Spea_1652 16 COG3097 COG3097, Uncharacterized protein conserved in bacteria Function unknown 157963573 Common - MSHA pilin protein MshA Spea_3761 7 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 157961668 Common - hypothetical protein Spea_1844 11 COG4984 COG4984, Predicted membrane protein Function unknown 157961365 Common - glycoside hydrolase family 3 domain protein Spea_1539 176 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 157961946 Common - fumarate reductase/succinate dehydrogenase flavoprotein domain protein Spea_2125 56 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 157960206 Common - diaminopimelate decarboxylase Spea_0377 218 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 157963439 Nonpathogen - GtrA family protein Spea_3627 1 COG2246 COG2246, Predicted membrane protein Function unknown 157963995 Common - hypothetical protein Spea_4184 14 COG2388 COG2388, Predicted acetyltransferase General function prediction only 157959914 Common - flagellar hook-basal body complex subunit FliE Spea_0084 45 COG1677 FliE, Flagellar hook-basal body protein Cell motility and secretion / Intracellular trafficking and secretion 157962718 Common - hypothetical protein Spea_2899 1 None None None 157962172 Common - excinuclease ABC, B subunit Spea_2351 229 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 157963183 Common - flavocytochrome c Spea_3368 218 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 157962208 Common - peptide deformylase Spea_2387 214 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 157962291 Common - phenylalanyl-tRNA synthetase, alpha subunit Spea_2470 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 157963236 Common - transcriptional regulator, LysR family Spea_3422 173 COG0583 LysR, Transcriptional regulator Transcription 157963248 Nonpathogen - hypothetical protein Spea_3434 1 None None None 157960617 Common - D-erythrose-4-phosphate dehydrogenase Spea_0789 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 157960500 Common - protein of unknown function DUF1111 Spea_0672 50 COG3488 COG3488, Predicted thiol oxidoreductase Energy production and conversion 157962902 Common - gamma-glutamyl phosphate reductase Spea_3084 188 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 157960339 Common - periplasmic copper-binding Spea_0510 52 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 157963717 Common - D-tyrosyl-tRNA(Tyr) deacylase Spea_3906 139 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 157962616 Common - AMP-dependent synthetase and ligase Spea_2795 215 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 157962892 Common - carbamoyl-phosphate synthase, large subunit Spea_3074 237 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 157961377 Nonpathogen - hypothetical protein Spea_1551 1 None None None 157963427 Common - protein of unknown function DUF1239 Spea_3613 32 COG3117 COG3117, Uncharacterized protein conserved in bacteria Function unknown 157960459 Common - glycine cleavage T protein (aminomethyl transferase) Spea_0630 121 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 157961601 Common - hypothetical protein Spea_1777 2 None None None 157963271 Common - transcriptional regulator, XRE family Spea_3457 30 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 157963031 Common - pseudouridine synthase Spea_3214 203 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 157963824 Common - bioH protein Spea_4013 106 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 157963418 Common - BolA family protein Spea_3604 52 COG5007 COG5007, Predicted transcriptional regulator, BolA superfamily Transcription 157960330 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Spea_0501 104 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 157962451 Common - hypothetical protein Spea_2630 3 None None None 157960783 Common - cytochrome c oxidase, cbb3-type, subunit I Spea_0955 174 COG3278 CcoN, Cbb3-type cytochrome oxidase, subunit 1 Posttranslational modification, protein turnover, chaperones 157960149 Common - hypothetical protein Spea_0320 20 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 157960227 Common - thioredoxin Spea_0398 232 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 157960870 Common - GCN5-related N-acetyltransferase Spea_1042 5 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 157960291 Common - protein of unknown function DUF107 Spea_0462 4 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 157960851 Common - protein of unknown function DUF81 Spea_1023 81 COG0730 COG0730, Predicted permeases General function prediction only 157963859 Common - hypothetical protein Spea_4048 7 None None None 157963381 Common - Enoyl-CoA hydratase/isomerase Spea_3567 173 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 157962793 Common - hypothetical protein Spea_2975 37 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 157963670 Common - cytochrome C family protein Spea_3859 33 None None None 157961845 Common - hydrogenase expression/formation protein HypE Spea_2024 132 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 157962675 Common - histone family protein nucleoid-structuring protein H-NS Spea_2856 27 COG2916 Hns, DNA-binding protein H-NS General function prediction only 157961152 Common - acriflavin resistance protein Spea_1324 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 157962833 Common - transcriptional regulator, AraC family Spea_3015 49 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 157963019 Common - 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase Spea_3202 139 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 157963293 Common - protein of unknown function DUF350 Spea_3479 5 None None None 157962535 Common - Glycerate kinase Spea_2714 81 COG1929 COG1929, Glycerate kinase Carbohydrate transport and metabolism 157959901 Common - flagellar basal-body rod protein FlgF Spea_0071 122 COG4787 FlgF, Flagellar basal body rod protein Cell motility and secretion 157961583 Common - hypothetical protein Spea_1759 7 None None None 157961930 Common - DsrE family protein Spea_2109 38 COG2923 DsrF, Uncharacterized protein involved in the oxidation of intracellular sulfur Inorganic ion transport and metabolism 157960409 Common - glycoside hydrolase family 2 TIM barrel Spea_0580 73 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 157961057 Nonpathogen - hypothetical protein Spea_1229 1 None None None 157961288 Common - phospholipase D/Transphosphatidylase Spea_1462 147 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 157962877 Common - ribosome-binding factor A Spea_3059 150 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 157963829 Common - histidine kinase Spea_4018 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157962133 Common - hypothetical protein Spea_2312 23 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 157962659 Common - protein of unknown function DUF1568 Spea_2839 11 None None None 157962506 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Spea_2685 201 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 157963038 Common - Glutathione synthase Spea_3221 135 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 157961276 Common - transcriptional regulator, TyrR Spea_1450 168 COG3283 TyrR, Transcriptional regulator of aromatic amino acids metabolism Transcription / Amino acid transport and metabolism 157961863 Common - transcriptional regulator, LysR family Spea_2042 103 COG0583 LysR, Transcriptional regulator Transcription 157962248 Common - periplasmic nitrate reductase, large subunit Spea_2427 184 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 157962002 Common - putative ATP-dependent protease La-relatedprotein Spea_2181 110 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 157961817 Common - hypothetical protein Spea_1996 16 COG3603 COG3603, Uncharacterized conserved protein Function unknown 157962989 Common - hypothetical protein Spea_3172 1 None None None 157963123 Nonpathogen - hypothetical protein Spea_3307 1 None None None 157963105 Nonpathogen - hypothetical protein Spea_3289 1 None None None 157960440 Nonpathogen - hypothetical protein Spea_0611 1 None None None 157961210 Common - response regulator receiver modulated CheB methylesterase Spea_1382 213 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 157961875 Common - alpha/beta hydrolase fold Spea_2054 164 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 157960581 Common - chromate transporter, chromate ion transporter (CHR) family Spea_0753 110 COG2059 ChrA, Chromate transport protein ChrA Inorganic ion transport and metabolism 157961707 Common - hypothetical protein Spea_1883 2 COG2515 Acd, 1-aminocyclopropane-1-carboxylate deaminase Amino acid transport and metabolism 157961821 Common - Cupin 4 family protein Spea_2000 63 COG2850 COG2850, Uncharacterized conserved protein Function unknown 157963156 Common - hypothetical protein Spea_3340 7 None None None 157962047 Common - Bax protein, putative Spea_2226 31 COG2992 Bax, Uncharacterized FlgJ-related protein General function prediction only 157961855 Common - asparaginyl-tRNA synthetase Spea_2034 222 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 157962242 Common - exodeoxyribonuclease V, alpha subunit Spea_2421 123 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 157963677 Common - transcriptional regulator, TetR family Spea_3866 9 COG1309 AcrR, Transcriptional regulator Transcription 157961820 Common - DNA polymerase III, epsilon subunit Spea_1999 192 COG2176 PolC, DNA polymerase III, alpha subunit (gram-positive type) DNA replication, recombination, and repair 157962776 Common - protein of unknown function DUF188 Spea_2958 97 COG1671 COG1671, Uncharacterized protein conserved in bacteria Function unknown 157962423 Common - hypothetical protein Spea_2602 12 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 157962573 Common - hypothetical protein Spea_2752 19 None None None 157963463 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Spea_3651 240 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 157960706 Common - two component transcriptional regulator, winged helix family Spea_0878 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157960035 Common - ribosomal protein S13 Spea_0206 243 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 157961445 Common - Sporulation domain protein Spea_1619 30 COG3147 DedD, Uncharacterized protein conserved in bacteria Function unknown 157961998 Common - acriflavin resistance protein Spea_2177 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 157963370 Common - DNA topoisomerase IV, A subunit Spea_3556 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 157962714 Common - hypothetical protein Spea_2895 21 COG4323 COG4323, Predicted membrane protein Function unknown 157961106 Common - hypothetical protein Spea_1278 2 None None None 157963528 Common - hypothetical protein Spea_3716 15 None None None 157960743 Common - GCN5-related N-acetyltransferase Spea_0915 23 COG0456 RimI, Acetyltransferases General function prediction only 157961171 Common - flagellar basal body FlaE domain protein Spea_1343 127 COG1749 FlgE, Flagellar hook protein FlgE Cell motility and secretion 157959966 Common - Methyltransferase type 12 Spea_0136 34 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 157960387 Common - protein of unknown function DUF81 Spea_0558 39 None None None 157962403 Common - peptidase M28 Spea_2582 53 COG2234 Iap, Predicted aminopeptidases General function prediction only 157960301 Nonpathogen - hypothetical protein Spea_0472 2 None None None 157960004 Common - ribosomal protein L1 Spea_0174 238 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 157960309 Common - Rhodanese domain protein Spea_0480 8 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 157960767 Common - GCN5-related N-acetyltransferase Spea_0939 65 COG3153 COG3153, Predicted acetyltransferase General function prediction only 157963197 Common - ABC transporter related Spea_3382 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 157962378 Common - histidine kinase Spea_2557 220 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 157960540 Common - phosphate-selective porin O and P Spea_0712 23 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 157962422 Common - protein of unknown function DUF58 Spea_2601 87 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 157964025 Common - Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) Spea_4214 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 157960484 Common - hypothetical protein Spea_0656 6 None None None 157960234 Common - hypothetical protein Spea_0405 4 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 157961968 Common - alpha/beta hydrolase fold Spea_2147 158 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 157960601 Common - GCN5-related N-acetyltransferase Spea_0773 15 COG0456 RimI, Acetyltransferases General function prediction only 157963753 Common - aldehyde dehydrogenase Spea_3942 221 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 157961709 Common - MscS mechanosensitive ion channel Spea_1885 9 None None None 157960427 Common - Alkaline phosphatase Spea_0598 82 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 157963366 Common - glycerophosphoryl diester phosphodiesterase Spea_3552 144 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 157961540 Common - protein of unknown function DUF6 transmembrane Spea_1716 21 None None None 157961920 Common - putative Zn-dependent aminopeptidase Spea_2099 38 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 157964015 Common - outer membrane protein Spea_4204 19 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 157959948 Common - sodium/glutamate symporter Spea_0118 51 COG0786 GltS, Na+/glutamate symporter Amino acid transport and metabolism 157961700 Common - hypothetical protein Spea_1876 1 None None None 157962822 Nonpathogen - hypothetical protein Spea_3004 2 None None None 157961547 Nonpathogen - hypothetical protein Spea_1723 3 None None None 157962250 Common - periplasmic nitrate reductase NapE Spea_2429 1 COG4459 NapE, Periplasmic nitrate reductase system, NapE component Energy production and conversion 157962737 Common - integrase, catalytic region Spea_2919 23 None None None 157961740 Common - methionyl-tRNA synthetase Spea_1917 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 157960779 Common - succinic semialdehyde dehydrogenase Spea_0951 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 157962066 Common - Transketolase central region Spea_2245 206 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 157960152 Common - hypothetical protein Spea_0323 17 None None None 157961933 Common - transcriptional regulator, LysR family Spea_2112 171 COG0583 LysR, Transcriptional regulator Transcription 157964067 Common - tRNA modification GTPase TrmE Spea_4256 228 COG0486 ThdF, Predicted GTPase General function prediction only 157960507 Common - diguanylate cyclase and serine/threonine protein kinase with TPR repeats Spea_0679 177 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 157962976 Nonpathogen - hydrolase (secreted protein) Spea_3159 3 None None None 157961412 Common - tryptophan synthase, beta subunit Spea_1586 224 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 157960400 Common - single-strand binding protein Spea_0571 213 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 157962749 Common - hypothetical protein Spea_2931 4 None None None 157963317 Common - glucose-methanol-choline oxidoreductase Spea_3503 60 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 157963706 Common - conserved hypothetical 4-hydroxybenzoyl-CoA thioesterase Spea_3895 57 COG0824 FcbC, Predicted thioesterase General function prediction only 157963853 Common - putative ferredoxin Spea_4042 34 COG2440 FixX, Ferredoxin-like protein Energy production and conversion 157961924 Nonpathogen - hypothetical protein Spea_2103 1 None None None 157961952 Common - short-chain dehydrogenase/reductase SDR Spea_2131 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157960549 Common - histidine kinase Spea_0721 202 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 157961456 Common - transcriptional regulator, LysR family Spea_1630 172 COG0583 LysR, Transcriptional regulator Transcription 157962093 Common - pentapeptide repeat protein Spea_2272 81 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 157961594 Common - lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA Spea_1770 248 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 157963238 Common - TonB-dependent receptor Spea_3424 110 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 157960534 Common - hypothetical protein Spea_0706 9 None None None 157960612 Nonpathogen - hypothetical protein Spea_0784 1 None None None 157960392 Nonpathogen - hypothetical protein Spea_0563 2 None None None 157960379 Common - hypothetical protein Spea_0550 22 None None None 157961063 Common - GTPase EngC Spea_1235 163 COG1162 COG1162, Predicted GTPases General function prediction only 157960616 Common - transketolase Spea_0788 221 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 157962529 Common - hypothetical protein Spea_2708 7 COG3188 FimD, P pilus assembly protein, porin PapC Cell motility and secretion / Intracellular trafficking and secretion 157964060 Common - Cobyrinic acid ac-diamide synthase Spea_4249 226 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 157962230 Common - AsmA family protein Spea_2409 73 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 157962840 Common - hypothetical protein Spea_3022 1 COG3371 COG3371, Predicted membrane protein Function unknown 157959865 Common - Microbial collagenase Spea_0035 14 None None None 157961883 Common - ferredoxin Spea_2062 44 COG0633 Fdx, Ferredoxin Energy production and conversion 157960962 Nonpathogen - hypothetical protein Spea_1134 1 None None None 157962849 Common - type IV pilus assembly PilZ Spea_3031 17 None None None 157961991 Common - acetyl-CoA acetyltransferase Spea_2170 170 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 157963176 Common - two component, sigma54 specific, transcriptional regulator, Fis family Spea_3361 178 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 157962672 Common - Na+/H+ antiporter NhaC Spea_2853 71 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 157960115 Common - histidine kinase Spea_0286 224 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157963491 Nonpathogen - hypothetical protein Spea_3679 1 None None None 157959888 Common - flagellar basal body-associated protein FliL Spea_0058 8 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 157960382 Common - two component transcriptional regulator, Fis family Spea_0553 218 COG4567 COG4567, Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain Signal transduction mechanisms / Transcription 157963027 Nonpathogen - hypothetical protein Spea_3210 2 None None None 157960270 Common - formate dehydrogenase accessory protein FdhE Spea_0441 41 COG3058 FdhE, Uncharacterized protein involved in formate dehydrogenase formation Posttranslational modification, protein turnover, chaperones 157962273 Common - hypothetical protein Spea_2452 1 None None None 157962080 Common - GCN5-related N-acetyltransferase Spea_2259 72 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 157963952 Common - hypothetical protein Spea_4141 3 None None None 157963061 Common - Xanthine/uracil/vitamin C permease Spea_3244 152 COG2252 COG2252, Permeases General function prediction only 157963258 Common - transcriptional regulator, NifA subfamily, Fis Family Spea_3444 171 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 157960813 Common - iron-sulfur cluster assembly accessory protein Spea_0985 166 COG0316 IscA, Uncharacterized conserved protein Function unknown 157963773 Common - hypothetical protein Spea_3962 3 None None None 157962317 Common - 3-oxoacyl-(acyl-carrier-protein) synthase III Spea_2496 220 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 157961306 Common - signal transduction histidine kinase, LytS Spea_1480 105 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 157959836 Common - glycyl-tRNA synthetase, beta subunit Spea_0006 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 157963340 Nonpathogen - hypothetical protein Spea_3526 2 None None None 157962620 Common - Enoyl-CoA hydratase/isomerase Spea_2799 179 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 157960370 Common - heavy metal efflux pump, CzcA family Spea_0541 177 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 157961070 Nonpathogen - hypothetical protein Spea_1242 1 None None None 157962163 Common - hypothetical protein Spea_2342 1 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 157963074 Common - Integrase catalytic region Spea_3257 142 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157960009 Common - ribosomal protein S12 Spea_0179 236 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 157962469 Common - TonB family protein Spea_2648 34 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 157961721 Nonpathogen - hypothetical protein Spea_1898 1 None None None 157961737 Common - protein of unknown function DUF34 Spea_1914 105 COG0327 COG0327, Uncharacterized conserved protein Function unknown 157961227 Common - WxcM domain protein Spea_1400 24 None None None 157961165 Common - SAF domain protein Spea_1337 43 COG1261 FlgA, Flagellar basal body P-ring biosynthesis protein Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 157961100 Common - hypothetical protein Spea_1272 69 COG3207 DIT1, Pyoverdine/dityrosine biosynthesis protein Secondary metabolites biosynthesis, transport, and catabolism 157961511 Common - protein of unknown function DUF540 Spea_1686 44 COG2981 CysZ, Uncharacterized protein involved in cysteine biosynthesis Amino acid transport and metabolism 157963723 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Spea_3912 46 COG0348 NapH, Polyferredoxin Energy production and conversion 157961800 Common - Integrase catalytic region Spea_1977 134 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157959928 Common - protein of unknown function DUF414 Spea_0098 23 COG3078 COG3078, Uncharacterized protein conserved in bacteria Function unknown 157960366 Common - hypothetical protein Spea_0537 5 None None None 157961248 Common - glycerol-3-phosphate cytidylyltransferase Spea_1422 59 COG0615 TagD, Cytidylyltransferase Cell envelope biogenesis, outer membrane / Lipid metabolism 157962235 Common - protein of unknown function DUF195 Spea_2414 149 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 157960836 Common - aldehyde dehydrogenase Spea_1008 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 157961724 Common - response regulator receiver modulated CheW protein Spea_1901 165 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 157960665 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Spea_0837 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 157962477 Common - helicase c2 Spea_2656 138 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 157959881 Common - Nucleotidyl transferase Spea_0051 218 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 157961336 Common - Acetyltransferase (isoleucine patch superfamily)-like protein Spea_1510 199 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 157963974 Common - protein of unknown function DUF81 Spea_4163 25 COG0730 COG0730, Predicted permeases General function prediction only 157963940 Common - molybdopterin oxidoreductase Spea_4129 188 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 157961733 Common - acetolactate synthase, small subunit Spea_1910 192 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 157962042 Common - hypothetical protein Spea_2221 66 COG2836 COG2836, Uncharacterized conserved protein Function unknown 157962106 Common - xylulokinase Spea_2285 171 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 157963981 Common - transcriptional regulator, histidine utilization repressor, GntR family Spea_4170 126 COG2188 PhnF, Transcriptional regulators Transcription 157963645 Common - amino-acid N-acetyltransferase Spea_3834 209 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 157962706 Common - UTP-GlnB uridylyltransferase, GlnD Spea_2887 123 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 157960710 Common - hypothetical protein Spea_0882 6 None None None 157962062 Common - hypothetical protein Spea_2241 6 None None None 157961748 Common - type IV pilus biogenesis protein PilZ Spea_1925 33 COG3215 PilZ, Tfp pilus assembly protein PilZ Cell motility and secretion / Intracellular trafficking and secretion 157961482 Common - transcriptional regulator, AraC family Spea_1656 26 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 157963452 Common - ABC transporter related Spea_3640 249 COG1124 DppF, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 157963950 Common - cytoplasmic chaperone TorD family protein Spea_4139 28 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 157963086 Common - GCN5-related N-acetyltransferase Spea_3270 10 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 157962883 Common - phosphoglucosamine mutase Spea_3065 241 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 157963406 Common - Adenylosuccinate synthase Spea_3592 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 157960055 Common - acetylornithine deacetylase (ArgE) Spea_0226 190 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 157962199 Common - thiazole biosynthesis protein ThiH Spea_2378 55 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 157959982 Common - general secretion pathway protein L Spea_0152 32 COG3297 PulL, Type II secretory pathway, component PulL Intracellular trafficking and secretion 157961430 Common - hypothetical protein Spea_1604 3 None None None 157961332 Common - protein of unknown function DUF454 Spea_1506 74 COG2832 COG2832, Uncharacterized protein conserved in bacteria Function unknown 157963306 Common - methyl-accepting chemotaxis sensory transducer with Cache sensor Spea_3492 154 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157961418 Common - protein of unknown function DUF1538 Spea_1592 23 None None None 157961339 Common - TonB-dependent receptor Spea_1513 112 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 157960282 Common - Radical SAM domain protein Spea_0453 34 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 157961745 Common - aminodeoxychorismate lyase Spea_1922 183 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 157962224 Common - Ribonuclease H Spea_2403 176 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 157961527 Common - aldehyde dehydrogenase Spea_1702 200 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 157961429 Common - 5-carboxymethyl-2-hydroxymuconate isomerase Spea_1603 17 COG3232 HpaF, 5-carboxymethyl-2-hydroxymuconate isomerase Amino acid transport and metabolism 157960165 Common - hypothetical protein Spea_0336 4 None None None 157963096 Common - multiple resistance and pH regulation protein F Spea_3280 21 COG2212 MnhF, Multisubunit Na+/H+ antiporter, MnhF subunit Inorganic ion transport and metabolism 157963395 Common - replicative DNA helicase Spea_3581 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 157960446 Common - hypothetical protein Spea_0617 4 None None None 157962557 Common - 3-Oxoacyl-(acyl-carrier-protein (ACP)) synthase III domain protein Spea_2736 187 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 157961308 Common - type IV pilus assembly PilZ Spea_1482 2 None None None 157960495 Common - GCN5-related N-acetyltransferase Spea_0667 36 COG0456 RimI, Acetyltransferases General function prediction only 157961002 Common - DoxX family protein Spea_1174 57 COG2259 COG2259, Predicted membrane protein Function unknown 157963012 Common - protein of unknown function DUF1458 Spea_3195 40 COG3360 COG3360, Uncharacterized conserved protein Function unknown 157963189 Common - periplasmic binding protein Spea_3374 154 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 157962656 Common - Sel1 domain protein repeat-containing protein Spea_2836 112 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 157963838 Common - Arylsulfotransferase Spea_4027 11 None None None 157960374 Common - protein of unknown function DUF442 Spea_0545 7 COG3453 COG3453, Uncharacterized protein conserved in bacteria Function unknown 157961710 Nonpathogen - hypothetical protein Spea_1886 1 None None None 157963284 Nonpathogen - hypothetical protein Spea_3470 1 None None None 157961239 Common - glycosyl transferase family 2 Spea_1412 199 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 157959921 Common - flagellar biosynthetic protein FliR Spea_0091 128 COG1684 FliR, Flagellar biosynthesis pathway, component FliR Cell motility and secretion / Intracellular trafficking and secretion 157963204 Nonpathogen - hypothetical protein Spea_3389 1 None None None 157960604 Common - protein of unknown function DUF306 Meta and HslJ Spea_0776 32 COG3187 HslJ, Heat shock protein Posttranslational modification, protein turnover, chaperones 157963053 Common - band 7 protein Spea_3236 105 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 157961893 Common - cytidylate kinase Spea_2072 205 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 157962076 Common - protein of unknown function DUF1315 Spea_2255 20 COG3139 COG3139, Uncharacterized protein conserved in bacteria Function unknown 157961989 Common - short-chain dehydrogenase/reductase SDR Spea_2168 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157961632 Common - uroporphyrin-III C-methyltransferase Spea_1808 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 157961426 Common - protein of unknown function DUF748 Spea_1600 44 None None None 157960818 Common - peptidase S9 prolyl oligopeptidase active site domain protein Spea_0990 91 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 157963477 Nonpathogen - hypothetical protein Spea_3665 4 None None None 157964053 Common - ATP synthase F1, alpha subunit Spea_4242 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 157961092 Common - hypothetical protein Spea_1264 5 None None None 157961639 Common - Tetratricopeptide TPR_2 repeat protein Spea_1815 4 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 157961037 Common - hypothetical protein Spea_1209 1 None None None 157962187 Common - aspartyl-tRNA synthetase Spea_2366 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 157960552 Common - hypothetical protein Spea_0724 2 COG1916 COG1916, Uncharacterized homolog of PrgY (pheromone shutdown protein) Function unknown 157961467 Nonpathogen - hypothetical protein Spea_1641 1 None None None 157962448 Common - hypothetical protein Spea_2627 1 None None None 157960858 Common - L-aspartate oxidase Spea_1030 226 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 157962752 Common - Propeptide PepSY amd peptidase M4 Spea_2934 2 COG3212 COG3212, Predicted membrane protein Function unknown 157961290 Common - sodium:dicarboxylate symporter Spea_1464 149 COG3633 SstT, Na+/serine symporter Amino acid transport and metabolism 157961016 Common - 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Spea_1188 189 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 157960894 Common - aspartate kinase Spea_1066 236 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 157961760 Common - hypothetical protein Spea_1937 3 None None None 157963819 Common - polysaccharide deacetylase Spea_4008 99 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 157963882 Common - choline/carnitine/betaine transporter Spea_4071 95 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 157962955 Common - PhoH family protein Spea_3138 198 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 157960092 Nonpathogen - hypothetical protein Spea_0263 1 None None None 157962104 Common - Monosaccharide-transporting ATPase Spea_2283 118 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 157960655 Common - peptidylprolyl isomerase FKBP-type Spea_0827 142 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 157961995 Common - nuclear transport factor 2 Spea_2174 10 None None None 157961058 Common - transcriptional regulator, AraC family Spea_1230 76 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 157962852 Common - hypothetical protein Spea_3034 17 COG3305 COG3305, Predicted membrane protein Function unknown 157962873 Common - Polyribonucleotide nucleotidyltransferase Spea_3055 239 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 157962239 Common - transglutaminase domain protein Spea_2418 93 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 157962665 Nonpathogen - hypothetical protein Spea_2846 1 None None None 157962889 Common - protein-export membrane protein SecD Spea_3071 205 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 157962083 Common - translation initiation factor IF-3 Spea_2262 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 157963520 Common - hypothetical protein Spea_3708 18 COG2862 COG2862, Predicted membrane protein Function unknown 157960344 Common - ABC transporter related Spea_0515 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 157963289 Common - hypothetical protein Spea_3475 3 None None None 157962915 Common - NADH:ubiquinone oxidoreductase, subunit F Spea_3098 160 COG2871 NqrF, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF Energy production and conversion 157960430 Common - Deoxyribonuclease I Spea_0601 30 COG2356 EndA, Endonuclease I DNA replication, recombination, and repair 157963358 Common - protein of unknown function UPF0079 Spea_3544 206 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 157963556 Common - ABC-2 type transporter Spea_3744 116 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 157963801 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Spea_3990 49 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 157960633 Common - tyrosine recombinase XerD Spea_0805 232 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 157963765 Common - DTW domain containing protein Spea_3954 38 COG3148 COG3148, Uncharacterized conserved protein Function unknown 157961439 Common - aspartate-semialdehyde dehydrogenase Spea_1613 236 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 157962933 Common - 2-dehydropantoate 2-reductase Spea_3116 98 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 157961671 Common - hypothetical protein Spea_1847 20 COG3784 COG3784, Uncharacterized protein conserved in bacteria Function unknown 157961792 Common - hypothetical protein Spea_1969 8 COG3308 COG3308, Predicted membrane protein Function unknown 157961051 Common - hypothetical protein Spea_1223 5 None None None 157961647 Common - transcriptional regulator, TetR family Spea_1823 5 COG1309 AcrR, Transcriptional regulator Transcription 157960276 Common - protein of unknown function DUF28 Spea_0447 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 157962993 Common - pseudouridine synthase Spea_3176 203 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 157963710 Common - hypothetical protein Spea_3899 1 None None None 157963756 Common - transcriptional regulator, LysR family Spea_3945 105 COG0583 LysR, Transcriptional regulator Transcription 157963658 Common - helix-turn-helix domain protein Spea_3847 21 None None None 157962357 Common - pseudouridine synthase Spea_2536 203 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 157963160 Common - cytoplasmic chaperone TorD family protein Spea_3344 24 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 157960971 Common - hypothetical protein Spea_1143 5 None None None 157963322 Common - Sel1 domain protein repeat-containing protein Spea_3508 80 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 157962090 Common - transposase Spea_2269 9 None None None 157962965 Common - protein of unknown function DUF163 Spea_3148 165 COG1576 COG1576, Uncharacterized conserved protein Function unknown 157960973 Common - Alkaline phosphatase Spea_1145 84 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 157963416 Common - histidine kinase Spea_3602 221 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 157961574 Common - hypothetical protein Spea_1750 4 None None None 157961514 Common - DNA ligase, NAD-dependent Spea_1689 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 157961896 Common - protein of unknown function DUF1049 Spea_2075 15 COG3771 COG3771, Predicted membrane protein Function unknown 157960877 Common - ribosomal protein S16 Spea_1049 212 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 157960424 Common - peptidase M50 Spea_0595 19 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 157961554 Common - efflux transporter, RND family, MFP subunit Spea_1730 152 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157963459 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Spea_3647 200 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 157963808 Common - transcriptional repressor, LexA family Spea_3997 173 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 157960351 Common - hypothetical protein Spea_0522 1 None None None 157962287 Common - Integrase catalytic region Spea_2466 142 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157961117 Common - diguanylate cyclase Spea_1289 179 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157960514 Common - UDP-N-acetylmuramate Spea_0686 209 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 157960266 Common - molybdopterin oxidoreductase Fe4S4 region Spea_0437 159 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 157962635 Common - hypothetical protein Spea_2815 1 None None None 157960902 Common - transaldolase Spea_1074 183 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 157960111 Common - hypothetical protein Spea_0282 9 None None None 157963488 Common - metallophosphoesterase Spea_3676 98 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 157963860 Common - transcriptional regulator, CadC Spea_4049 6 COG3710 CadC, DNA-binding winged-HTH domains Transcription 157960645 Common - protein of unknown function DUF808 Spea_0817 61 COG2354 COG2354, Uncharacterized protein conserved in bacteria Function unknown 157962906 Common - hypothetical protein Spea_3089 1 None None None 157960864 Common - signal peptidase I Spea_1036 212 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 157963066 Common - transcriptional regulator, GntR family Spea_3249 134 COG1802 GntR, Transcriptional regulators Transcription 157960468 Common - protein of unknown function UPF0016 Spea_0640 77 COG2119 COG2119, Predicted membrane protein Function unknown 157963629 Common - cell division protein FtsL Spea_3818 41 COG3116 FtsL, Cell division protein Cell division and chromosome partitioning 157960457 Common - multi-sensor hybrid histidine kinase Spea_0628 225 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 157959916 Common - OmpA/MotB domain protein Spea_0086 107 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 157959974 Common - general secretion pathway protein D Spea_0144 141 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 157960189 Common - ATP-dependent DNA helicase Rep Spea_0360 231 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 157963983 Common - hypothetical protein Spea_4172 2 None None None 157963731 Common - glycosyl hydrolase, BNR repeat-containing protein Spea_3920 14 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 157960978 Common - efflux transporter, RND family, MFP subunit Spea_1150 155 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157960150 Common - Cupin 2 conserved barrel domain protein Spea_0321 1 None None None 157961150 Common - methyl-accepting chemotaxis sensory transducer Spea_1322 148 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 157964037 Common - hypothetical protein Spea_4226 24 COG3205 COG3205, Predicted membrane protein Function unknown 157963017 Common - cytochrome c biogenesis protein transmembrane region Spea_3200 147 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 157963239 Common - Na+/H+ antiporter NhaC Spea_3425 56 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 157959981 Common - General secretion pathway protein K Spea_0151 36 COG3156 PulK, Type II secretory pathway, component PulK Intracellular trafficking and secretion 157961654 Common - nicotinamide mononucleotide transporter PnuC Spea_1830 54 COG3201 PnuC, Nicotinamide mononucleotide transporter Coenzyme metabolism 157962948 Nonpathogen - hypothetical protein Spea_3131 1 None None None 157960328 Common - protein of unknown function DUF6 transmembrane Spea_0499 17 COG2962 RarD, Predicted permeases General function prediction only 157960808 Common - hypothetical protein Spea_0980 5 None None None 157960028 Common - ribosomal protein S8 Spea_0198 226 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 157961350 Common - hypothetical protein Spea_1524 9 None None None 157963136 Common - transcriptional regulator, Fis family Spea_3320 175 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 157963908 Common - molybdopterin-guanine dinucleotide biosynthesis protein A Spea_4097 97 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 157961341 Common - Exo-alpha-sialidase Spea_1515 18 COG4409 NanH, Neuraminidase (sialidase) Carbohydrate transport and metabolism 157960780 Common - 4-aminobutyrate aminotransferase Spea_0952 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 157962016 Common - DNA-directed DNA polymerase Spea_2195 171 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 157963114 Common - NTPase (NACHT family)-like protein Spea_3298 12 COG5635 COG5635, Predicted NTPase (NACHT family) Signal transduction mechanisms 157963263 Common - D-serine ammonia-lyase Spea_3449 39 COG3048 DsdA, D-serine dehydratase Amino acid transport and metabolism 157961019 Common - protein-L-isoaspartate O-methyltransferase Spea_1191 160 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 157960528 Common - PepB aminopeptidase Spea_0700 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 157961121 Common - protein of unknown function DUF980 Spea_1293 58 COG3228 COG3228, Uncharacterized protein conserved in bacteria Function unknown 157962206 Common - channel protein, hemolysin III family Spea_2385 119 COG1272 COG1272, Predicted membrane protein, hemolysin III homolog General function prediction only 157963005 Common - molybdopterin oxidoreductase Spea_3188 181 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 157961620 Common - ferric uptake regulator, Fur family Spea_1796 197 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 157961697 Common - 4-hydroxyphenylpyruvate dioxygenase Spea_1873 76 COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins Amino acid transport and metabolism / General function prediction only 157963580 Common - pilus (MSHA type) biogenesis protein MshL Spea_3768 140 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 157961788 Common - uracil-xanthine permease Spea_1965 125 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 157959854 Common - Integrase catalytic region Spea_0024 142 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157960321 Common - hypothetical protein Spea_0492 10 None None None 157962657 Nonpathogen - hypothetical protein Spea_2837 1 None None None 157960243 Common - methylation site containing protein Spea_0414 1 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 157962024 Common - hypothetical protein Spea_2203 11 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 157960066 Common - type IV pilus secretin PilQ Spea_0237 142 COG4796 HofQ, Type II secretory pathway, component HofQ Intracellular trafficking and secretion 157959896 Common - flagellar hook-associated protein FlgK Spea_0066 124 COG1256 FlgK, Flagellar hook-associated protein Cell motility and secretion 157960982 Common - protein of unknown function DUF88 Spea_1154 56 COG1432 COG1432, Uncharacterized conserved protein Function unknown 157960755 Common - cold-shock DNA-binding domain protein Spea_0927 54 COG3326 COG3326, Predicted membrane protein Function unknown 157962152 Common - transposase Spea_2331 9 None None None 157962136 Common - hypothetical protein Spea_2315 14 COG0433 COG0433, Predicted ATPase General function prediction only 157960787 Common - DNA primase Spea_0959 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 157964038 Common - sodium/hydrogen exchanger Spea_4227 155 COG3263 COG3263, NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain Inorganic ion transport and metabolism 157961587 Common - sulfatase Spea_1763 33 COG3083 COG3083, Predicted hydrolase of alkaline phosphatase superfamily General function prediction only 157963048 Common - hypothetical protein Spea_3231 10 None None None 157963313 Common - hypothetical protein Spea_3499 6 None None None 157962543 Nonpathogen - hypothetical protein Spea_2722 1 None None None 157961664 Common - membrane-fusion protein Spea_1840 69 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157962350 Common - Leucyltransferase Spea_2529 134 COG2360 Aat, Leu/Phe-tRNA-protein transferase Posttranslational modification, protein turnover, chaperones 157959857 Common - potassium uptake protein, TrkH family Spea_0027 137 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 157962280 Common - histidinol-phosphatase Spea_2459 218 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 157960099 Common - S-formylglutathione hydrolase Spea_0270 109 COG0627 COG0627, Predicted esterase General function prediction only 157962145 Common - GCN5-related N-acetyltransferase Spea_2324 157 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 157961500 Common - transcriptional regulator, LysR family Spea_1675 185 COG0583 LysR, Transcriptional regulator Transcription 157960584 Common - peptide chain release factor 2 Spea_0756 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 157961046 Common - putative lipoprotein Spea_1218 6 None None None 157959843 Common - ybaK/ebsC protein Spea_0013 108 COG2606 EbsC, Uncharacterized conserved protein Function unknown 157962856 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Spea_3038 165 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 157961173 Common - flagellar basal-body rod protein FlgG Spea_1345 126 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 157961678 Common - protein of unknown function DUF938 Spea_1854 49 None None None 157959875 Common - protein of unknown function DUF115 Spea_0045 10 COG2604 COG2604, Uncharacterized protein conserved in bacteria Function unknown 157960176 Common - branched-chain amino acid aminotransferase Spea_0347 220 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 157961408 Common - hypothetical protein Spea_1582 7 COG3349 COG3349, Uncharacterized conserved protein Function unknown 157963420 Common - toluene tolerance family protein Spea_3606 67 COG2854 Ttg2D, ABC-type transport system involved in resistance to organic solvents, auxiliary component Secondary metabolites biosynthesis, transport, and catabolism 157961024 Common - alanyl-tRNA synthetase Spea_1196 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 157963429 Common - ABC transporter related Spea_3615 249 COG1137 YhbG, ABC-type (unclassified) transport system, ATPase component General function prediction only 157961134 Common - histidyl-tRNA synthetase Spea_1306 248 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 157961327 Common - dihydrouridine synthase DuS Spea_1501 210 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 157961262 Common - PHP domain protein Spea_1436 44 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 157962021 Common - Appr-1-p processing domain protein Spea_2200 107 COG2110 COG2110, Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 General function prediction only 157962058 Common - protein of unknown function DUF885 Spea_2237 42 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 157962787 Common - two component transcriptional regulator, winged helix family Spea_2969 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157961509 Common - response regulator receiver modulated diguanylate cyclase Spea_1684 214 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 157960595 Common - cysteine desulfurase, SufS subfamily Spea_0767 239 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 157961853 Common - nickel-dependent hydrogenase large subunit Spea_2032 105 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 157962687 Common - diguanylate cyclase Spea_2868 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 157963530 Common - hypothetical protein Spea_3718 1 None None None 157962803 Nonpathogen - hypothetical protein Spea_2985 1 None None None 157961420 Common - putative signal-transduction protein with CBS domains Spea_1594 27 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 157961904 Nonpathogen - hypothetical protein Spea_2083 1 None None None 157963700 Common - phosphopantetheine-binding Spea_3889 92 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 157960696 Common - heat shock protein DnaJ domain protein Spea_0868 91 COG1076 DjlA, DnaJ-domain-containing proteins 1 Posttranslational modification, protein turnover, chaperones 157960107 Common - hypothetical protein Spea_0278 25 COG3788 COG3788, Uncharacterized relative of glutathione S-transferase, MAPEG superfamily General function prediction only 157960456 Common - ABC transporter related Spea_0627 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 157960224 Common - succinate dehydrogenase and fumarate reductase iron-sulfur protein Spea_0395 207 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 157962648 Nonpathogen - hypothetical protein Spea_2828 2 COG4886 COG4886, Leucine-rich repeat (LRR) protein Function unknown 157961314 Common - cysteine desulfurase IscS Spea_1488 240 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 157964047 Common - TonB-dependent siderophore receptor Spea_4236 111 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 157961914 Common - pseudouridine synthase Spea_2093 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 157962972 Common - lipoate-protein ligase B Spea_3155 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 157960157 Nonpathogen - hypothetical protein Spea_0328 1 None None None 157962837 Common - peptidase U32 Spea_3019 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 157962522 Nonpathogen - hypothetical protein Spea_2701 1 None None None 157963109 Nonpathogen - hypothetical protein Spea_3293 1 None None None 157960405 Common - Aldose 1-epimerase Spea_0576 90 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 157961392 Common - Integral membrane protein TerC Spea_1566 101 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 157963465 Common - Pyridoxal-5'-phosphate-dependent protein beta subunit Spea_3653 223 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 157960314 Common - NosL family protein Spea_0485 27 COG4314 NosL, Predicted lipoprotein involved in nitrous oxide reduction Energy production and conversion 157961301 Common - Rhodanese domain protein Spea_1475 121 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 157963791 Common - signal recognition particle-docking protein FtsY Spea_3980 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 157962968 Common - lytic murein transglycosylase B Spea_3151 102 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 157961203 Common - flagellar biosynthesis protein FlhA Spea_1375 127 COG1298 FlhA, Flagellar biosynthesis pathway, component FlhA Cell motility and secretion / Intracellular trafficking and secretion 157962301 Common - arginine decarboxylase Spea_2480 143 COG1166 SpeA, Arginine decarboxylase (spermidine biosynthesis) Amino acid transport and metabolism 157961623 Common - translation elongation factor G Spea_1799 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 157962565 Common - phosphate ABC transporter, inner membrane subunit PstA Spea_2744 224 COG4985 COG4985, ABC-type phosphate transport system, auxiliary component Inorganic ion transport and metabolism 157960797 Common - ErfK/YbiS/YcfS/YnhG family protein Spea_0969 85 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 157960342 Common - transcriptional regulator, CadC Spea_0513 4 COG3710 CadC, DNA-binding winged-HTH domains Transcription 157962126 Common - hypothetical protein Spea_2305 14 None None None 157962537 Common - hypothetical protein Spea_2716 15 None None None 157960733 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Spea_0905 14 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 157962492 Common - extracellular solute-binding protein family 5 Spea_2671 208 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 157962821 Common - hypothetical protein Spea_3003 21 None None None 157960074 Common - phosphoglycolate phosphatase Spea_0245 191 COG0546 Gph, Predicted phosphatases General function prediction only 157963448 Common - TOBE domain protein Spea_3636 72 COG3585 MopI, Molybdopterin-binding protein Coenzyme metabolism 157963653 Common - GTP cyclohydrolase I Spea_3842 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 157961185 Common - sigma54 specific transcriptional regulator, Fis family Spea_1357 170 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 157960041 Common - Heme exporter protein D (CcmD) Spea_0212 24 COG3114 CcmD, Heme exporter protein D Intracellular trafficking and secretion 157961683 Common - transcriptional regulator, XRE family Spea_1859 2 COG2522 COG2522, Predicted transcriptional regulator General function prediction only 157962941 Common - Invasion gene expression up-regulator SirB Spea_3124 37 COG3094 COG3094, Uncharacterized protein conserved in bacteria Function unknown 157960849 Common - NUDIX hydrolase Spea_1021 113 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 157963738 Common - hypothetical protein Spea_3927 22 COG4461 LprI, Uncharacterized protein conserved in bacteria, putative lipoprotein Function unknown 157960031 Common - ribosomal protein S5 Spea_0201 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 157962664 Nonpathogen - hypothetical protein Spea_2845 1 None None None 157961985 Common - hypothetical protein Spea_2164 1 None None None 157963831 Common - transcriptional regulator, LysR family Spea_4020 75 COG0583 LysR, Transcriptional regulator Transcription 157961487 Common - protein of unknown function DUF214 Spea_1662 86 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 157961642 Common - hypothetical protein Spea_1818 7 None None None 157963102 Nonpathogen - hypothetical protein Spea_3286 3 None None None 157963930 Common - molybdenum cofactor biosynthesis protein B Spea_4119 185 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 157962978 Common - transposase IS116/IS110/IS902 family protein Spea_3161 98 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 157963962 Common - glycoside hydrolase family 37 Spea_4151 47 COG1626 TreA, Neutral trehalase Carbohydrate transport and metabolism 157960569 Common - hypothetical protein Spea_0741 4 None None None 157962649 Nonpathogen - hypothetical protein Spea_2829 1 COG5645 COG5645, Predicted periplasmic lipoprotein General function prediction only 157963180 Common - efflux transporter, RND family, MFP subunit Spea_3365 97 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 157960738 Common - Leucyl aminopeptidase Spea_0910 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 157960182 Common - transcriptional regulator, AsnC family Spea_0353 155 COG1522 Lrp, Transcriptional regulators Transcription 157961795 Common - SirA family protein Spea_1972 1 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 157961885 Common - ribonucleoside-diphosphate reductase, alpha subunit Spea_2064 210 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 157962520 Common - cytochrome C family protein Spea_2699 37 None None None 157960211 Common - Egg lysin (Sperm-lysin) Spea_0382 6 None None None 157961258 Common - response regulator receiver modulated serine phosphatase Spea_1432 223 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 157962987 Common - Ornithine cyclodeaminase Spea_3170 97 COG2423 COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog Amino acid transport and metabolism 157961649 Common - thioesterase superfamily protein Spea_1825 30 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 157963748 Common - hypothetical protein Spea_3937 1 None None None 157962771 Common - glutamate decarboxylase Spea_2953 69 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 157961927 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Spea_2106 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 157963375 Common - protein of unknown function DUF1249 Spea_3561 24 COG3151 COG3151, Uncharacterized protein conserved in bacteria Function unknown 157961458 Common - galactokinase Spea_1632 81 COG0153 GalK, Galactokinase Carbohydrate transport and metabolism 157962673 Common - Electron transfer flavoprotein alpha subunit Spea_2854 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 157959908 Common - hypothetical protein Spea_0078 8 None None None 157959945 Common - glycosyl transferase group 1 Spea_0115 126 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 157961072 Common - CBS domain containing protein Spea_1244 15 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 157961348 Common - dihydrodipicolinate synthetase Spea_1522 200 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 157961659 Common - hypothetical protein Spea_1835 1 None None None 157962438 Common - hypothetical protein Spea_2617 13 None None None 157962488 Common - phage shock protein C, PspC Spea_2667 35 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 157961219 Common - response regulator receiver protein Spea_1391 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 157963232 Common - transcriptional regulator, AraC family Spea_3418 76 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 157960509 Common - Integrase catalytic region Spea_0681 134 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157963547 Common - major facilitator superfamily MFS_1 Spea_3735 30 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 157963290 Nonpathogen - hypothetical protein Spea_3476 1 None None None 157963273 Common - type III restriction protein res subunit Spea_3459 46 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 157963007 Common - hypothetical protein Spea_3190 1 None None None 157960173 Common - ketol-acid reductoisomerase Spea_0344 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 157963361 Common - Exonuclease RNase T and DNA polymerase III Spea_3547 88 COG1949 Orn, Oligoribonuclease (3'->5' exoribonuclease) RNA processing and modification 157962504 Common - Methylenetetrahydrofolate dehydrogenase (NADP(+)) Spea_2683 223 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 157963430 Common - RNA polymerase, sigma 54 subunit, RpoN Spea_3616 145 COG1508 RpoN, DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog Transcription 157963571 Common - MSHA pilin protein MshC Spea_3759 1 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 157963682 Common - Pyridoxal-dependent decarboxylase Spea_3871 92 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 157960502 Common - hypothetical protein Spea_0674 4 None None None 157959938 Common - transcriptional regulator, TetR family Spea_0108 47 COG1309 AcrR, Transcriptional regulator Transcription 157960389 Common - O-succinylhomoserine (thiol)-lyase Spea_0560 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 157963844 Common - 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoAhydratase Spea_4033 25 COG2030 MaoC, Acyl dehydratase Lipid metabolism 157959834 Common - DNA gyrase, B subunit Spea_0004 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 157962875 Common - ribosomal protein S15 Spea_3057 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 157962453 Common - peptidase M23B Spea_2632 187 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 157963874 Common - Glutathione S-transferase domain Spea_4063 28 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 157962110 Common - transferase hexapeptide repeat containing protein Spea_2289 141 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 157960251 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Spea_0422 193 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 157961769 Common - putative RNA methylase Spea_1946 163 COG0116 COG0116, Predicted N6-adenine-specific DNA methylase DNA replication, recombination, and repair 157963295 Common - hypothetical protein Spea_3481 8 COG3789 COG3789, Uncharacterized protein conserved in bacteria Function unknown 157963743 Common - protein of unknown function Spy-related Spea_3932 20 COG3678 CpxP, P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism 157962389 Common - Pol-Pal system-associated acyl-CoA thioesterase Spea_2568 130 COG0824 FcbC, Predicted thioesterase General function prediction only 157963885 Common - amidohydrolase Spea_4074 168 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 157961102 Common - hypothetical protein Spea_1274 21 None None None 157960888 Common - sigma 54 modulation protein/ribosomal protein S30EA Spea_1060 77 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 157961633 Common - glycosyl transferase family 3 Spea_1809 92 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 157961888 Common - DNA gyrase, A subunit Spea_2067 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 157960442 Common - hypothetical protein Spea_0613 13 COG3188 FimD, P pilus assembly protein, porin PapC Cell motility and secretion / Intracellular trafficking and secretion 157962082 Common - ribosomal protein L35 Spea_2261 129 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 157961278 Common - maleylacetoacetate isomerase Spea_1452 61 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 157962725 Common - transcriptional regulator, putative Spea_2906 25 COG5240 SEC21, Vesicle coat complex COPI, gamma subunit Intracellular trafficking and secretion 157963125 Nonpathogen - hypothetical protein Spea_3309 1 COG3941 COG3941, Mu-like prophage protein General function prediction only 157962868 Common - nucleoside transporter Spea_3050 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 157960663 Common - hypothetical protein Spea_0835 2 None None None 157963425 Common - KpsF/GutQ family protein Spea_3611 175 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 157962729 Common - PfaD family protein Spea_2910 20 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 157962900 Common - Integrase catalytic region Spea_3082 134 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 157962135 Common - HNH nuclease Spea_2314 27 COG3440 COG3440, Predicted restriction endonuclease Defense mechanisms 157963276 Nonpathogen - hypothetical protein Spea_3462 1 None None None 157960688 Common - bis(5'-nucleosyl)-tetraphosphatase (symmetrical) Spea_0860 88 None None None 157960716 Common - putative transcriptional regulator Spea_0888 52 COG2345 COG2345, Predicted transcriptional regulator Transcription 157962246 Common - periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family Spea_2425 48 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 157960135 Common - hypothetical protein Spea_0306 1 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 157960415 Common - serine/threonine protein kinase Spea_0586 93 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 157962298 Common - pyridoxamine 5'-phosphate oxidase Spea_2477 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 157961472 Common - chromosome segregation and condensation protein ScpA Spea_1646 138 COG1354 COG1354, Uncharacterized conserved protein Function unknown 157963642 Common - thioesterase superfamily protein Spea_3831 49 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 157962684 Common - Patatin Spea_2865 47 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 157963100 Common - NADH dehydrogenase (quinone) Spea_3284 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 157964071 Common - ribosomal protein L34 Spea_4260 197 None None None 157963437 Common - transposase IS3/IS911 family protein Spea_3625 1 None None None 157959954 Common - protein of unknown function DUF333 Spea_0124 23 COG3042 Hlx, Putative hemolysin General function prediction only 157963195 Common - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Spea_3380 118 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 157962355 Common - cold-shock DNA-binding domain protein Spea_2534 179 COG1278 CspC, Cold shock proteins Transcription 157961567 Common - type I phosphodiesterase/nucleotide pyrophosphatase Spea_1743 17 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 157962261 Common - Disulphide bond formation protein DsbB Spea_2440 58 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 157960473 Common - lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase Spea_0645 100 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 157960968 Common - MscS Mechanosensitive ion channel Spea_1140 202 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 157961966 Common - protein of unknown function DUF523 Spea_2145 56 COG1683 COG1683, Uncharacterized conserved protein Function unknown 157963615 Common - peptidase M23B Spea_3804 191 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 157962320 Common - protein of unknown function DUF177 Spea_2499 55 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 157961209 Common - CheA signal transduction histidine kinase Spea_1381 155 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 157962333 Common - diacylglycerol kinase Spea_2512 66 COG0818 DgkA, Diacylglycerol kinase Cell envelope biogenesis, outer membrane 157963333 Common - glutamine amidotransferase of anthranilate synthase Spea_3519 238 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 157962052 Common - AAA ATPase central domain protein Spea_2231 234 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 157960947 Common - cytochrome bd ubiquinol oxidase subunit I Spea_1119 159 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 157961066 Common - glycosyl transferase group 1 Spea_1238 222 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 157961699 Common - transcriptional regulator, LysR family Spea_1875 166 COG0583 LysR, Transcriptional regulator Transcription 157962011 Common - drug resistance transporter, EmrB/QacA subfamily Spea_2190 185 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 157962167 Common - hypothetical protein Spea_2346 5 None None None 157962899 Common - protein of unknown function DUF6 transmembrane Spea_3081 40 COG2962 RarD, Predicted permeases General function prediction only 157961597 Common - Peptidase M11 gametolysin Spea_1773 68 COG1470 COG1470, Predicted membrane protein Function unknown 157962861 Common - phosphoserine phosphatase SerB Spea_3043 150 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 157960575 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Spea_0747 249 COG3634 AhpF, Alkyl hydroperoxide reductase, large subunit Posttranslational modification, protein turnover, chaperones 157961362 Common - hypothetical protein Spea_1536 7 None None None 157960200 Common - protein of unknown function DUF513 hemX Spea_0371 55 COG2959 HemX, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 157962040 Common - heavy metal translocating P-type ATPase Spea_2219 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 157962366 Common - hypothetical protein Spea_2545 4 None None None 157963993 Common - hypothetical protein Spea_4182 8 None None None 157964065 Common - Lysine exporter protein (LYSE/YGGA) Spea_4254 121 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 157961608 Common - Succinate dehydrogenase cytochrome b556 subunit Spea_1784 93 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 157964040 Common - phosphate ABC transporter, inner membrane subunit PstC Spea_4229 227 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 157960810 Common - cytochrome c class I Spea_0982 54 COG2863 COG2863, Cytochrome c553 Energy production and conversion 157961084 Common - hypothetical protein Spea_1256 5 None None None 157960932 Common - glucose/galactose transporter Spea_1104 47 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 157962215 Common - Coproporphyrinogen dehydrogenase Spea_2394 203 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 157959972 Common - RNA-binding S4 domain protein Spea_0142 91 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 157961590 Common - hypothetical protein Spea_1766 15 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 157961414 Common - anthranilate phosphoribosyltransferase Spea_1588 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 157959898 Common - flagellar P-ring protein Spea_0068 104 COG1706 FlgI, Flagellar basal-body P-ring protein Cell motility and secretion 157961742 Common - uridine kinase Spea_1919 95 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 157962103 Common - periplasmic binding protein/LacI transcriptional regulator Spea_2282 99 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 157962805 Common - OmpA/MotB domain protein Spea_2987 110 COG1360 MotB, Flagellar motor protein Cell motility and secretion 157963902 Common - GCN5-related N-acetyltransferase Spea_4091 5 COG3375 COG3375, Uncharacterized conserved protein Function unknown 157962099 Nonpathogen - hypothetical protein Spea_2278 1 None None None 157964049 Common - DsrE family protein Spea_4238 26 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 157961282 Common - glutamyl-tRNA synthetase Spea_1456 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 157963495 Nonpathogen - hypothetical protein Spea_3683 1 None None None 157960751 Common - peptidylprolyl isomerase FKBP-type Spea_0923 141 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 157963880 Common - transposase Spea_4069 9 None None None 157961476 Common - hypothetical protein Spea_1650 13 None None None 157963689 Common - DNA-directed RNA polymerase, omega subunit Spea_3878 93 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 157962918 Common - NADH:ubiquinone oxidoreductase, subunit C Spea_3101 44 COG2869 NqrC, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC Energy production and conversion 157963926 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Spea_4115 149 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 157963610 Common - hypothetical protein Spea_3798 4 None None None 157962784 Common - Microbial collagenase Spea_2966 14 None None None 157963768 Common - transcriptional regulator, LysR family Spea_3957 100 COG0583 LysR, Transcriptional regulator Transcription 157962034 Common - hypothetical protein Spea_2213 3 None None None 157960964 Common - transcriptional regulator, LysR family Spea_1136 168 COG0583 LysR, Transcriptional regulator Transcription 157961198 Common - flagellar biosynthesis protein FliO Spea_1370 8 COG3190 FliO, Flagellar biogenesis protein Cell motility and secretion 157962811 Common - ATP-NAD/AcoX kinase Spea_2993 238 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 157963976 Common - Na+/H+ antiporter NhaC Spea_4165 73 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 157963969 Common - MscS Mechanosensitive ion channel Spea_4158 82 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 157960113 Common - peptidase S9 prolyl oligopeptidase active site domain protein Spea_0284 114 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 157961549 Common - hypothetical protein Spea_1725 2 None None None 157961187 Common - two component, sigma54 specific, transcriptional regulator, Fis family Spea_1359 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 157961388 Common - efflux transporter, RND family, MFP subunit Spea_1562 63 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 157963174 Common - transcriptional regulator, TetR family Spea_3358 117 COG1309 AcrR, Transcriptional regulator Transcription 157963849 Common - choline/carnitine/betaine transporter Spea_4038 96 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 157963036 Common - glucose sorbosone dehydrogenase Spea_3219 115 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 157963509 Nonpathogen - hypothetical protein Spea_3697 1 None None None 157961375 Common - hypothetical protein Spea_1549 11 COG3608 COG3608, Predicted deacylase General function prediction only 157959886 Common - MotA/TolQ/ExbB proton channel Spea_0056 95 COG1291 MotA, Flagellar motor component Cell motility and secretion 157960372 Common - peptidase U6 penicillin-insensitive murein endopeptidase Spea_0543 39 COG3770 MepA, Murein endopeptidase Cell envelope biogenesis, outer membrane 157961246 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Spea_1420 167 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 157962347 Common - Lysine exporter protein (LYSE/YGGA) Spea_2526 80 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 157963022 Common - lipolytic protein G-D-S-L family Spea_3205 102 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 157962275 Nonpathogen - hypothetical protein Spea_2454 1 None None None 157959863 Common - DNA protecting protein DprA Spea_0033 209 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 157963871 Common - transporter, hydrophobe/amphiphile efflux-1 (HAE1) family Spea_4060 178 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 157962429 Common - sodium/proline symporter Spea_2608 188 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 157962765 Nonpathogen - hypothetical protein Spea_2947 3 None None None 157963719 Common - Prolyl aminopeptidase Spea_3908 94 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 157962716 Common - hypothetical protein Spea_2897 23 None None None 157961245 Common - NAD-dependent epimerase/dehydratase Spea_1419 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 157961359 Common - Ig domain protein group 1 domain protein Spea_1533 60 None None None 157962142 Common - 2-methylcitrate synthase/citrate synthase II Spea_2321 194 COG0372 GltA, Citrate synthase Energy production and conversion 157962315 Common - 3-oxoacyl-(acyl-carrier-protein) reductase Spea_2494 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157962232 Common - hypothetical protein Spea_2411 1 None None None 157962161 Common - Peptidyl-dipeptidase A Spea_2340 16 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 157961099 Common - helicase domain protein Spea_1271 130 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 157961230 Common - DegT/DnrJ/EryC1/StrS aminotransferase Spea_1403 193 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 157961731 Common - 5'-Nucleotidase domain protein Spea_1908 136 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 157963029 Common - transcriptional regulator, LysR family Spea_3212 166 COG0583 LysR, Transcriptional regulator Transcription 157963315 Common - ABC transporter related Spea_3501 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 157960105 Common - hypothetical protein Spea_0276 8 COG2831 FhaC, Hemolysin activation/secretion protein Intracellular trafficking and secretion 157959933 Common - ThiJ/PfpI domain protein Spea_0103 38 COG3155 ElbB, Uncharacterized protein involved in an early stage of isoprenoid biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 157961337 Common - Sel1 domain protein repeat-containing protein Spea_1511 40 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 157962229 Common - intracellular proteinase inhibitor domain protein Spea_2408 1 None None None 157959961 Common - 3,4-dihydroxy-2-butanone 4-phosphate synthase Spea_0131 228 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 157959848 Common - fatty oxidation complex, alpha subunit FadB Spea_0018 181 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 157960364 Common - Class I peptide chain release factor Spea_0535 117 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 157963921 Common - two component transcriptional regulator, winged helix family Spea_4110 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 157961447 Common - amidophosphoribosyltransferase Spea_1621 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 157962000 Common - SEC-C motif domain protein Spea_2179 9 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 157962467 Common - diguanylate cyclase Spea_2646 5 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 157961163 Common - FlgN family protein Spea_1335 7 COG3418 COG3418, Flagellar biosynthesis/type III secretory pathway chaperone Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 157963728 Common - sodium:dicarboxylate symporter Spea_3917 159 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 157961837 Common - TadE family protein Spea_2016 7 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 157961735 Common - drug resistance transporter, Bcr/CflA subfamily Spea_1912 153 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 157961381 Common - protein of unknown function DUF991 Spea_1555 20 COG3102 COG3102, Uncharacterized protein conserved in bacteria Function unknown 157960481 Common - sulfite reductase (NADPH) flavoprotein, alpha chain Spea_0653 107 COG0369 CysJ, Sulfite reductase, alpha subunit (flavoprotein) Inorganic ion transport and metabolism 157961785 Common - putative serine protein kinase, PrkA Spea_1962 70 COG2766 PrkA, Putative Ser protein kinase Signal transduction mechanisms 157960704 Common - protein of unknown function DUF1289 Spea_0876 20 COG3313 COG3313, Predicted Fe-S protein General function prediction only 157960030 Common - ribosomal protein L18 Spea_0200 206 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 157960741 Common - RDD domain containing protein Spea_0913 18 COG1714 COG1714, Predicted membrane protein/domain Function unknown 157960236 Common - mutator MutT protein Spea_0407 163 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 157963368 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Spea_3554 224 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 157960461 Common - hypothetical protein Spea_0632 40 COG3647 COG3647, Predicted membrane protein Function unknown 157962405 Common - tRNA/rRNA methyltransferase (SpoU) Spea_2584 21 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 157962575 Common - Microbial collagenase Spea_2754 18 None None None 157960037 Common - ribosomal protein S4 Spea_0208 216 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 157960040 Common - CcmE/CycJ protein Spea_0211 92 COG2332 CcmE, Cytochrome c-type biogenesis protein CcmE Posttranslational modification, protein turnover, chaperones 157964017 Common - type I secretion membrane fusion protein, HlyD family Spea_4206 120 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 157962004 Common - hypothetical protein Spea_2183 5 None None None 157960303 Nonpathogen - hypothetical protein Spea_0474 1 None None None 157962306 Common - cold-shock DNA-binding domain protein Spea_2485 182 COG1278 CspC, Cold shock proteins Transcription 157961552 Common - membrane protein involved in aromatic hydrocarbon degradation Spea_1728 58 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 157963721 Common - hypothetical protein Spea_3910 7 None None None 157962991 Common - transcriptional regulator, LysR family Spea_3174 192 COG0583 LysR, Transcriptional regulator Transcription 157962395 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Spea_2574 226 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 157963647 Common - ribosomal protein L28 Spea_3836 160 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 157961702 Nonpathogen - integral membrane protein TerC Spea_1878 1 None None None 157962475 Common - porin Gram-negative type Spea_2654 27 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 157960764 Common - aminotransferase class-III Spea_0936 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 157962420 Common - acetyl-CoA C-acyltransferase FadI Spea_2599 177 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 157963692 Common - tRNA guanosine-2'-O-methyltransferase Spea_3881 184 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 157960002 Common - NusG antitermination factor Spea_0172 215 COG0250 NusG, Transcription antiterminator Transcription 157961996 Common - acyl-CoA dehydrogenase domain protein Spea_2175 137 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 157962847 Common - glyceraldehyde 3-phosphate dehydrogenase Spea_3029 13 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 157960785 Common - Gluconate 2-dehydrogenase (acceptor) Spea_0957 88 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 157959946 Common - glycosyl transferase family 25 Spea_0116 25 COG3306 COG3306, Glycosyltransferase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 157962255 Common - hypothetical protein Spea_2434 6 None None None 157962441 Common - hypothetical protein Spea_2620 2 None None None 157960691 Common - 4-hydroxythreonine-4-phosphate dehydrogenase Spea_0863 159 COG1995 PdxA, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 157959997 Common - UDP-N-acetylenolpyruvoylglucosamine reductase Spea_0167 206 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 157962578 Common - ribonuclease H Spea_2757 182 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 157963518 Common - transposase Spea_3706 9 None None None 157963522 Common - CheC, inhibitor of MCP methylation Spea_3710 199 COG1776 CheC, Chemotaxis protein CheC, inhibitor of MCP methylation Cell motility and secretion / Signal transduction mechanisms 157961935 Common - 3 alpha-hydroxysteroid dehydrogenase/carbonyl reductase Spea_2114 234 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 157963532 Common - Formate--tetrahydrofolate ligase Spea_3720 89 COG2759 MIS1, Formyltetrahydrofolate synthetase Nucleotide transport and metabolism 157960547 Common - sodium:dicarboxylate symporter Spea_0719 164 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 157963855 Common - hypothetical protein Spea_4044 17 None None None 157960121 Common - hypothetical protein Spea_0292 4 None None None 157962747 Common - TonB-dependent heme/hemoglobin receptor family protein Spea_2929 128 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 157962759 Common - hypothetical protein Spea_2941 4 None None None 157963215 Common - Adenosylhomocysteinase Spea_3401 178 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 157963500 Nonpathogen - hypothetical protein Spea_3688 1 None None None 157964023 Common - HI0933 family protein Spea_4212 141 COG2081 COG2081, Predicted flavoproteins General function prediction only 157960536 Common - GCN5-related N-acetyltransferase Spea_0708 30 COG0456 RimI, Acetyltransferases General function prediction only 157960614 Common - GCN5-related N-acetyltransferase Spea_0786 6 COG2153 ElaA, Predicted acyltransferase General function prediction only 157961107 Nonpathogen - transcriptional regulator, XRE family Spea_1279 2 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 157960086 Common - Substrate-binding region of ABC-type glycine betaine transport system Spea_0257 26 COG2113 ProX, ABC-type proline/glycine betaine transport systems, periplasmic components Amino acid transport and metabolism 157962376 Common - FAD dependent oxidoreductase Spea_2555 121 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 157962401 Common - diguanylate cyclase Spea_2580 180 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 157962735 Common - putative deoxyguanosinetriphosphate triphosphohydrolase Spea_2917 159 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 157963960 Common - peptidase M6 immune inhibitor A Spea_4149 47 COG4412 COG4412, Uncharacterized protein conserved in bacteria Function unknown 157960610 Common - hypothetical protein Spea_0782 12 None None None 157960402 Common - transposase Spea_0573 9 None None None 157963732 Nonpathogen - hypothetical protein Spea_3921 1 None None None 157962091 Common - PEBP family protein Spea_2270 127 COG1881 COG1881, Phospholipid-binding protein General function prediction only