Anaeromyxobacter sp. Fw109-5, complete genome NC_009675 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 153002933 Common - glycosyl transferase group 1 Anae109_0054 107 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153006713 Nonpathogen - Sulfate transporter/antisigma-factor antagonist STAS Anae109_3875 1 None None None 153006913 Nonpathogen - helix-turn-helix domain protein Anae109_4076 1 COG1709 COG1709, Predicted transcriptional regulator Transcription 153003007 Common - hypothetical protein Anae109_0130 56 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 153006410 Nonpathogen - hypothetical protein Anae109_3570 2 None None None 153006506 Common - ATPase-like protein Anae109_3667 28 COG3903 COG3903, Predicted ATPase General function prediction only 153004147 Common - proton-translocating NADH-quinone oxidoreductase, chain M Anae109_1280 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 153004445 Common - thioredoxin Anae109_1582 231 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 153007225 Common - hypothetical protein Anae109_4388 7 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 153006267 Common - Ham1 family protein Anae109_3424 234 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 153003310 Common - hypothetical protein Anae109_0436 22 None None None 153004429 Nonpathogen - hypothetical protein Anae109_1566 2 None None None 153004182 Common - lysine 2,3-aminomutase YodO family protein Anae109_1315 127 COG1509 KamA, Lysine 2,3-aminomutase Amino acid transport and metabolism 153004457 Common - CBS domain containing protein Anae109_1594 106 COG0517 COG0517, FOG: CBS domain General function prediction only 153005085 Common - ribosomal protein L1 Anae109_2224 249 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 153004691 Nonpathogen - hypothetical protein Anae109_1829 6 None None None 153005514 Nonpathogen - hypothetical protein Anae109_2654 2 None None None 153005353 Common - excinuclease ABC, B subunit Anae109_2493 228 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 153006197 Common - histidine kinase Anae109_3354 71 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 153007233 Common - alpha/beta hydrolase fold Anae109_4396 28 COG3243 PhaC, Poly(3-hydroxyalkanoate) synthetase Lipid metabolism 153003817 Common - PP-loop domain protein Anae109_0949 170 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 153003304 Common - putative RNA methylase Anae109_0430 117 COG0116 COG0116, Predicted N6-adenine-specific DNA methylase DNA replication, recombination, and repair 153004084 Common - molybdopterin oxidoreductase Anae109_1217 181 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 153007298 Common - CheA signal transduction histidine kinase Anae109_4461 157 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 153004287 Nonpathogen - hypothetical protein Anae109_1421 1 None None None 153004606 Common - aminoacyl-histidine dipeptidase Anae109_1744 58 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 153006512 Common - helix-turn-helix domain protein Anae109_3673 14 None None None 153004941 Nonpathogen - hypothetical protein Anae109_2079 1 None None None 153005814 Common - protein of unknown function DUF558 Anae109_2956 46 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 153005913 Common - ABC transporter related Anae109_3057 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 153003183 Nonpathogen - hypothetical protein Anae109_0308 1 None None None 153003609 Common - Radical SAM domain protein Anae109_0737 64 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 153007192 Nonpathogen - hypothetical protein Anae109_4355 4 None None None 153003323 Common - methionyl-tRNA formyltransferase Anae109_0449 224 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 153006766 Common - Methyltransferase type 11 Anae109_3928 23 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 153002969 Common - outer membrane lipoprotein carrier protein LolA Anae109_0090 46 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 153004809 Common - protein of unknown function UPF0102 Anae109_1947 46 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 153004195 Nonpathogen - hypothetical protein Anae109_1328 2 COG3350 COG3350, Uncharacterized conserved protein Function unknown 153006215 Common - Tetratricopeptide TPR_2 repeat protein Anae109_3372 58 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 153006932 Common - efflux transporter, RND family, MFP subunit Anae109_4095 105 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153007284 Common - UDP-glucose 6-dehydrogenase Anae109_4447 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 153003780 Common - peptidase S1 and S6 chymotrypsin/Hap Anae109_0912 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 153005481 Common - PHP domain protein Anae109_2621 29 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 153003630 Common - ribosomal protein S21 Anae109_0759 113 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 153004669 Nonpathogen - peptidase M56 BlaR1 Anae109_1807 2 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 153005314 Common - carbonic anhydrase Anae109_2454 88 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 153005340 Common - AAA ATPase central domain protein Anae109_2480 215 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 153003537 Common - cytidine deaminase Anae109_0665 31 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 153004519 Common - cytochrome d ubiquinol oxidase, subunit II Anae109_1656 156 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 153003979 Nonpathogen - surface antigen variable number repeat protein Anae109_1112 2 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 153004910 Nonpathogen - type IV pilus assembly PilZ Anae109_2048 2 None None None 153004204 Common - fumarate reductase/succinate dehydrogenase flavoprotein domain protein Anae109_1337 14 COG3075 GlpB, Anaerobic glycerol-3-phosphate dehydrogenase Amino acid transport and metabolism 153004856 Common - Transketolase central region Anae109_1994 213 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 153003094 Nonpathogen - hypothetical protein Anae109_0217 2 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 153004461 Nonpathogen - hypothetical protein Anae109_1598 1 None None None 153006631 Common - aconitate hydratase 1 Anae109_3793 223 COG1048 AcnA, Aconitase A Energy production and conversion 153003624 Common - protein of unknown function DUF125 transmembrane Anae109_0752 85 COG1814 COG1814, Uncharacterized membrane protein Function unknown 153005053 Common - dihydroorotase, multifunctional complex type Anae109_2192 213 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 153006844 Nonpathogen - hypothetical protein Anae109_4007 1 None None None 153002932 Common - protein of unknown function DUF6 transmembrane Anae109_0053 64 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 153003011 Nonpathogen - type IV pilus assembly PilZ Anae109_0134 1 COG3215 PilZ, Tfp pilus assembly protein PilZ Cell motility and secretion / Intracellular trafficking and secretion 153003927 Nonpathogen - hypothetical protein Anae109_1060 1 None None None 153007293 Nonpathogen - hypothetical protein Anae109_4456 1 None None None 153005609 Common - Rhomboid family protein Anae109_2750 10 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 153004704 Nonpathogen - hypothetical protein Anae109_1842 1 None None None 153007149 Common - RNA polymerase, sigma 54 subunit, RpoN Anae109_4312 145 COG1508 RpoN, DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog Transcription 153003478 Common - transposase IS4 family protein Anae109_0606 21 None None None 153004647 Common - Peptidyl-dipeptidase A Anae109_1785 16 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 153006847 Nonpathogen - hypothetical protein Anae109_4010 2 COG3857 AddB, ATP-dependent nuclease, subunit B DNA replication, recombination, and repair 153005871 Nonpathogen - hypothetical protein Anae109_3015 1 None None None 153003545 Nonpathogen - hypothetical protein Anae109_0673 1 COG4726 PilX, Tfp pilus assembly protein PilX Cell motility and secretion / Intracellular trafficking and secretion 153005351 Common - histidine kinase Anae109_2491 223 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153003766 Common - ABC-2 type transporter Anae109_0898 127 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 153006284 Common - peptidase U34 dipeptidase Anae109_3441 26 COG4690 PepD, Dipeptidase Amino acid transport and metabolism 153007133 Common - ABC transporter related Anae109_4296 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 153005298 Common - histidine kinase Anae109_2438 222 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 153006260 Common - signal transduction histidine kinase, LytS Anae109_3417 103 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 153004696 Nonpathogen - lipoprotein, putative Anae109_1834 2 None None None 153004743 Common - ribosomal protein L35 Anae109_1881 121 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 153002944 Nonpathogen - hypothetical protein Anae109_0065 2 None None None 153003081 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Anae109_0204 233 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 153005366 Common - D-3-phosphoglycerate dehydrogenase Anae109_2506 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 153004241 Common - porphobilinogen deaminase Anae109_1375 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 153005603 Common - two component transcriptional regulator, LuxR family Anae109_2743 223 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 153004399 Common - hypothetical protein Anae109_1534 15 None None None 153003747 Nonpathogen - hypothetical protein Anae109_0879 3 COG3678 CpxP, P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism 153006374 Nonpathogen - putative CheW protein Anae109_3534 2 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153003356 Common - Peroxidase Anae109_0482 206 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 153003561 Common - hypothetical protein Anae109_0689 7 COG3168 PilP, Tfp pilus assembly protein PilP Cell motility and secretion / Intracellular trafficking and secretion 153002939 Common - penicillin-binding protein, 1A family Anae109_0060 201 COG5009 MrcA, Membrane carboxypeptidase/penicillin-binding protein Cell envelope biogenesis, outer membrane 153005600 Common - fatty acid/phospholipid synthesis protein PlsX Anae109_2740 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 153003018 Common - Tetratricopeptide TPR_2 repeat protein Anae109_0141 28 COG3824 COG3824, Uncharacterized protein conserved in bacteria Function unknown 153006354 Nonpathogen - hypothetical protein Anae109_3512 1 None None None 153006254 Common - hypothetical protein Anae109_3411 21 None None None 153004331 Common - hypothetical protein Anae109_1465 18 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 153005619 Common - cytochrome c peroxidase family protein Anae109_2760 53 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 153004579 Nonpathogen - hypothetical protein Anae109_1716 1 None None None 153005951 Common - SAF domain protein Anae109_3096 36 COG4091 COG4091, Predicted homoserine dehydrogenase Amino acid transport and metabolism 153006539 Common - peptidase M50 Anae109_3701 49 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 153003489 Nonpathogen - hypothetical protein Anae109_0617 2 None None None 153003168 Common - hypothetical protein Anae109_0292 30 None None None 153007129 Nonpathogen - hypothetical protein Anae109_4292 2 None None None 153006763 Common - D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase Anae109_3925 110 COG2027 DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) Cell envelope biogenesis, outer membrane 153006125 Nonpathogen - hypothetical protein Anae109_3276 1 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 153006562 Common - succinyl-CoA synthetase, beta subunit Anae109_3724 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 153005090 Common - translation elongation factor Tu Anae109_2229 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 153005562 Common - ATPase associated with various cellular activities AAA_5 Anae109_2702 100 COG0714 COG0714, MoxR-like ATPases General function prediction only 153004270 Nonpathogen - hypothetical protein Anae109_1404 1 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 153005067 Common - histidine kinase Anae109_2206 205 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153006588 Common - recA protein Anae109_3750 224 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 153005268 Nonpathogen - hypothetical protein Anae109_2408 2 None None None 153006116 Common - Methyltransferase type 12 Anae109_3264 28 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 153004123 Nonpathogen - hypothetical protein Anae109_1256 1 COG3748 COG3748, Predicted membrane protein Function unknown 153006328 Nonpathogen - hypothetical protein Anae109_3486 1 None None None 153003739 Nonpathogen - TonB family protein Anae109_0871 2 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 153005773 Common - hypothetical protein Anae109_2914 12 None None None 153005307 Common - HAD-superfamily subfamily IB hydrolase, TIGR01490 Anae109_2447 75 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 153004844 Common - protein of unknown function DUF329 Anae109_1982 50 COG3024 COG3024, Uncharacterized protein conserved in bacteria Function unknown 153006241 Common - Tetratricopeptide TPR_2 repeat protein Anae109_3398 149 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153003883 Common - copper-translocating P-type ATPase Anae109_1015 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 153003328 Common - PBS lyase HEAT domain protein repeat-containing protein Anae109_0454 16 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 153005734 Common - acyl-CoA dehydrogenase domain protein Anae109_2875 160 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 153003120 Nonpathogen - hypothetical protein Anae109_0243 7 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 153005104 Common - ApbE family lipoprotein Anae109_2243 120 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 153005249 Common - Chloride channel core Anae109_2388 133 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 153002981 Common - response regulator receiver protein Anae109_0102 189 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153003129 Common - MATE efflux family protein Anae109_0252 49 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 153005225 Common - lactoylglutathione lyase Anae109_2364 140 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 153006237 Nonpathogen - hypothetical protein Anae109_3394 1 None None None 153002908 Common - major facilitator superfamily MFS_1 Anae109_0029 15 COG3202 COG3202, ATP/ADP translocase Energy production and conversion 153006779 Common - peptidase dimerisation domain protein Anae109_3942 138 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 153003042 Common - Mannose-1-phosphate guanylyltransferase (GDP) Anae109_0165 161 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 153004066 Nonpathogen - hypothetical protein Anae109_1199 2 None None None 153006708 Common - ABC transporter related Anae109_3870 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 153005010 Common - transcriptional regulator, LysR family Anae109_2149 138 COG0583 LysR, Transcriptional regulator Transcription 153006733 Nonpathogen - PE-PGRS family protein Anae109_3895 1 None None None 153003875 Common - DNA polymerase LigD polymerase domain Anae109_1007 66 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 153003891 Common - efflux transporter, RND family, MFP subunit Anae109_1023 160 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153004432 Nonpathogen - hypothetical protein Anae109_1569 1 None None None 153002880 Common - chromosomal replication initiator protein DnaA Anae109_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 153003824 Common - cytochrome c-type protein Anae109_0956 27 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 153003965 Common - aminotransferase class V Anae109_1098 212 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 153006364 Common - Polysulphide reductase NrfD Anae109_3524 30 COG5557 COG5557, Polysulphide reductase Energy production and conversion 153006979 Common - outer membrane efflux protein Anae109_4142 86 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 153005148 Nonpathogen - Sporulation domain protein Anae109_2287 2 COG3087 FtsN, Cell division protein Cell division and chromosome partitioning 153007249 Common - ABC transporter related Anae109_4412 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 153004353 Common - response regulator receiver protein Anae109_1487 216 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153003971 Common - (Glutamate--ammonia-ligase) adenylyltransferase Anae109_1104 119 COG1391 GlnE, Glutamine synthetase adenylyltransferase Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms 153007317 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Anae109_4480 143 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 153005492 Common - Non-specific protein-tyrosine kinase Anae109_2632 179 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 153003387 Common - hydrogenase expression/synthesis HypA Anae109_0514 42 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 153003628 Common - histidine biosynthesis protein Anae109_0756 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 153005610 Common - protein of unknown function UPF0047 Anae109_2751 134 COG0432 COG0432, Uncharacterized conserved protein Function unknown 153006605 Common - DSBA oxidoreductase Anae109_3767 113 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 153004525 Common - ABC transporter related Anae109_1662 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 153003556 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_0684 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153004258 Nonpathogen - hypothetical protein Anae109_1392 1 None None None 153005829 Common - NAD(P)(+) transhydrogenase (AB-specific) Anae109_2971 160 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 153002902 Common - hypothetical protein Anae109_0023 8 COG5439 COG5439, Uncharacterized conserved protein Function unknown 153004672 Common - two component transcriptional regulator, LuxR family Anae109_1810 209 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 153005716 Common - Rhodanese domain protein Anae109_2857 39 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 153005300 Common - response regulator receiver sensor signal transduction histidine kinase Anae109_2440 223 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153002915 Common - Na+ symporter Anae109_0036 171 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 153003907 Common - transcriptional regulator, TetR family Anae109_1039 61 COG1309 AcrR, Transcriptional regulator Transcription 153004489 Common - oxidoreductase Anae109_1626 16 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153004075 Common - hypothetical protein Anae109_1208 15 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153004863 Common - amino acid-binding ACT domain protein Anae109_2001 120 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 153006905 Common - hypothetical protein Anae109_4068 12 None None None 153005097 Nonpathogen - hypothetical protein Anae109_2236 2 None None None 153003958 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_1091 99 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 153004686 Nonpathogen - hypothetical protein Anae109_1824 1 None None None 153005168 Common - putative esterase Anae109_2307 34 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 153006899 Common - ABC transporter related Anae109_4062 247 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 153007242 Common - major facilitator superfamily MFS_1 Anae109_4405 85 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153002924 Common - Butyrate kinase Anae109_0045 99 COG3426 COG3426, Butyrate kinase Energy production and conversion 153007236 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_4399 173 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153006299 Nonpathogen - hypothetical protein Anae109_3456 2 None None None 153006457 Common - peptidase M24 Anae109_3617 145 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 153007101 Common - heavy metal efflux pump, CzcA family Anae109_4264 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 153006972 Common - metallophosphoesterase Anae109_4135 68 COG0622 COG0622, Predicted phosphoesterase General function prediction only 153003905 Common - zinc finger, UBP-type Anae109_1037 23 COG5207 UBP14, Isopeptidase T Posttranslational modification, protein turnover, chaperones 153004367 Common - protein of unknown function DUF107 Anae109_1501 71 COG1030 NfeD, Membrane-bound serine protease (ClpP class) Posttranslational modification, protein turnover, chaperones 153004654 Common - transcriptional regulator, LysR family Anae109_1792 174 COG0583 LysR, Transcriptional regulator Transcription 153003346 Common - molybdenum cofactor biosynthesis protein C Anae109_0472 193 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 153004006 Common - NusA antitermination factor Anae109_1139 219 COG0195 NusA, Transcription elongation factor Transcription 153003637 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Anae109_0766 240 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 153006679 Nonpathogen - hypothetical protein Anae109_3841 1 None None None 153006599 Common - conserved hypothetical protein 103 Anae109_3761 156 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 153007214 Common - protein of unknown function DUF47 Anae109_4377 64 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 153004894 Common - cation diffusion facilitator family transporter Anae109_2032 143 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 153007087 Common - PAS/PAC sensor signal transduction histidine kinase Anae109_4250 221 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 153005427 Nonpathogen - H+transporting two-sector ATPase E subunit Anae109_2567 1 COG1390 NtpE, Archaeal/vacuolar-type H+-ATPase subunit E Energy production and conversion 153005943 Nonpathogen - hypothetical protein Anae109_3088 4 None None None 153004547 Common - GreA/GreB family elongation factor Anae109_1684 70 COG0782 GreA, Transcription elongation factor Transcription 153006270 Common - selenide, water dikinase Anae109_3427 189 COG0709 SelD, Selenophosphate synthase Amino acid transport and metabolism 153004422 Nonpathogen - hypothetical protein Anae109_1559 1 None None None 153006772 Common - DNA repair protein RadC Anae109_3935 176 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 153007095 Common - histidine kinase Anae109_4258 214 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153003480 Nonpathogen - hypothetical protein Anae109_0608 1 None None None 153007044 Common - Radical SAM domain protein Anae109_4207 81 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 153006016 Common - PAS/PAC sensor signal transduction histidine kinase Anae109_3161 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153003497 Common - response regulator receiver protein Anae109_0625 203 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153004847 Nonpathogen - hypothetical protein Anae109_1985 1 None None None 153006015 Nonpathogen - Tetratricopeptide TPR_4 Anae109_3160 1 None None None 153007272 Common - glycosyl transferase group 1 Anae109_4435 104 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153006397 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_3557 32 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153007269 Common - Ferredoxin--nitrite reductase Anae109_4432 106 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 153004327 Nonpathogen - hypothetical protein Anae109_1461 1 COG0392 COG0392, Predicted integral membrane protein Function unknown 153004040 Common - Extracellular ligand-binding receptor Anae109_1173 143 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 153005286 Common - Hemerythrin HHE cation binding domain protein Anae109_2426 22 None None None 153006524 Common - Lytic transglycosylase catalytic Anae109_3686 175 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 153005841 Nonpathogen - hypothetical protein Anae109_2983 1 None None None 153003256 Nonpathogen - hypothetical protein Anae109_0382 1 None None None 153003947 Common - phage integrase family protein Anae109_1080 10 None None None 153004155 Common - NADH-quinone oxidoreductase, B subunit Anae109_1288 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 153004500 Common - Cupin 2 conserved barrel domain protein Anae109_1637 15 None None None 153003647 Common - DNA repair protein RecN Anae109_0776 197 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 153004738 Common - 3-isopropylmalate dehydratase, small subunit Anae109_1876 211 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 153003789 Common - glycogen/starch/alpha-glucan phosphorylase Anae109_0921 136 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 153003841 Nonpathogen - hypothetical protein Anae109_0973 2 None None None 153005759 Common - HNH endonuclease Anae109_2900 5 COG1403 McrA, Restriction endonuclease Defense mechanisms 153005412 Common - short-chain dehydrogenase/reductase SDR Anae109_2552 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153002893 Common - lipoprotein signal peptidase Anae109_0014 189 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 153005635 Nonpathogen - putative regulatory protein, FmdB family Anae109_2776 3 None None None 153004313 Common - ribonuclease R Anae109_1447 192 COG0557 VacB, Exoribonuclease R Transcription 153006622 Common - NADH dehydrogenase (quinone) Anae109_3784 168 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 153005553 Common - DNA topoisomerase I Anae109_2693 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 153007178 Nonpathogen - MJ0042 family finger-like protein Anae109_4341 2 COG0457 NrfG, FOG: TPR repeat General function prediction only 153004344 Common - nicotinate-nucleotide pyrophosphorylase Anae109_1478 201 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 153007150 Common - ABC transporter related Anae109_4313 249 COG1137 YhbG, ABC-type (unclassified) transport system, ATPase component General function prediction only 153004177 Common - protein of unknown function DUF77 Anae109_1310 56 COG0011 COG0011, Uncharacterized conserved protein Function unknown 153004962 Common - metallophosphoesterase Anae109_2100 14 COG1409 Icc, Predicted phosphohydrolases General function prediction only 153003285 Nonpathogen - HNH endonuclease Anae109_0411 3 COG1403 McrA, Restriction endonuclease Defense mechanisms 153005654 Nonpathogen - hypothetical protein Anae109_2795 1 None None None 153003983 Nonpathogen - hypothetical protein Anae109_1116 1 None None None 153004228 Nonpathogen - hypothetical protein Anae109_1362 6 None None None 153003105 Common - iojap-like protein Anae109_0228 201 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 153003455 Common - Rieske (2Fe-2S) domain protein Anae109_0582 49 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 153003614 Common - type III secretion exporter Anae109_0742 7 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 153005893 Common - sodium:neurotransmitter symporter Anae109_3037 88 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 153003141 Common - oligopeptide transporter, OPT family Anae109_0264 40 COG1297 COG1297, Predicted membrane protein Function unknown 153005241 Common - 2-dehydropantoate 2-reductase Anae109_2380 28 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 153006052 Common - conserved hypothetical protein 698 Anae109_3197 117 COG2855 COG2855, Predicted membrane protein Function unknown 153005598 Common - malonyl CoA-acyl carrier protein transacylase Anae109_2738 208 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 153006900 Common - putative phenylacetate-CoA ligase Anae109_4063 46 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 153004472 Common - putative RNA methylase Anae109_1609 39 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 153004384 Nonpathogen - VanZ family protein Anae109_1519 1 COG5652 COG5652, Predicted integral membrane protein Function unknown 153005708 Nonpathogen - hypothetical protein Anae109_2849 1 None None None 153004540 Common - ABC branched-chain amino acid transporter, periplasmic ligand biinding protein Anae109_1677 87 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 153006277 Nonpathogen - hypothetical protein Anae109_3434 2 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 153004919 Common - LuxR family transcriptional regulator Anae109_2057 10 None None None 153007266 Common - polysaccharide export protein Anae109_4429 113 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 153006200 Common - protein of unknown function DUF336 Anae109_3357 80 COG3193 GlcG, Uncharacterized protein, possibly involved in utilization of glycolate and propanediol General function prediction only 153003433 Common - methyltransferase Anae109_0560 52 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153005520 Common - peptidase M48 Ste24p Anae109_2660 126 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 153005995 Nonpathogen - hypothetical protein Anae109_3140 1 None None None 153005458 Common - response regulator receiver protein Anae109_2598 207 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153006707 Common - binding-protein-dependent transport systems inner membrane component Anae109_3869 160 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 153005015 Nonpathogen - hypothetical protein Anae109_2154 2 COG3071 HemY, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 153003420 Common - hypothetical protein Anae109_0547 19 None None None 153003398 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_0525 157 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153004070 Common - arginine biosynthesis bifunctional protein ArgJ Anae109_1203 167 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 153007158 Common - pseudouridine synthase, RluA family Anae109_4321 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 153003589 Common - Haloacid dehalogenase domain protein hydrolase Anae109_0717 15 COG0546 Gph, Predicted phosphatases General function prediction only 153006363 Common - hydrogenase (NiFe) small subunit HydA Anae109_3523 77 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 153003500 Common - 6-phosphogluconate dehydrogenase NAD-binding Anae109_0628 166 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 153005445 Common - elongation factor G domain IV Anae109_2585 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 153006068 Nonpathogen - hypothetical protein Anae109_3214 10 COG4641 COG4641, Uncharacterized protein conserved in bacteria Function unknown 153006645 Common - SsrA-binding protein Anae109_3807 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 153005934 Nonpathogen - hypothetical protein Anae109_3079 1 None None None 153006183 Nonpathogen - hypothetical protein Anae109_3340 1 None None None 153006792 Common - hypothetical protein Anae109_3955 70 COG2945 COG2945, Predicted hydrolase of the alpha/beta superfamily General function prediction only 153004279 Common - Sua5/YciO/YrdC/YwlC family protein Anae109_1413 196 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 153006099 Common - DNA-directed DNA polymerase Anae109_3247 180 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 153005261 Common - DTW domain containing protein Anae109_2401 12 COG3148 COG3148, Uncharacterized conserved protein Function unknown 153005781 Common - TRAP C4-dicarboxylate transport system permease DctM subunit Anae109_2922 122 COG4664 FcbT3, TRAP-type mannitol/chloroaromatic compound transport system, large permease component Secondary metabolites biosynthesis, transport, and catabolism 153003851 Common - Threonine aldolase Anae109_0983 101 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 153003732 Common - molydopterin dinucleotide-binding region Anae109_0862 175 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 153007098 Common - hypothetical protein Anae109_4261 11 COG4633 COG4633, Uncharacterized protein conserved in bacteria Function unknown 153004393 Common - tetratricopeptide repeat protein Anae109_1528 10 None None None 153006419 Common - UTP-glucose-1-phosphate uridylyltransferase Anae109_3579 230 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 153006227 Nonpathogen - hypothetical protein Anae109_3384 2 None None None 153003840 Common - chromosome partitioning-like ATPase Anae109_0972 18 COG0003 ArsA, Predicted ATPase involved in chromosome partitioning Cell division and chromosome partitioning 153004229 Common - hypothetical protein Anae109_1363 11 None None None 153005545 Common - ornithine carbamoyltransferase Anae109_2685 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 153003403 Nonpathogen - Tetratricopeptide TPR_4 Anae109_0530 3 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 153007142 Nonpathogen - hydrogenase maturation protease Anae109_4305 1 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 153005474 Common - sugar transferase Anae109_2614 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 153005409 Common - peptidylprolyl isomerase FKBP-type Anae109_2549 132 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 153003311 Nonpathogen - hypothetical protein Anae109_0437 1 None None None 153003544 Common - Tfp pilus assembly protein tip-associated adhesin PilY1-like protein Anae109_0672 22 COG3419 PilY1, Tfp pilus assembly protein, tip-associated adhesin PilY1 Cell motility and secretion / Intracellular trafficking and secretion 153006549 Common - DNA-directed RNA polymerase, omega subunit Anae109_3711 115 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 153006698 Common - Enoyl-CoA hydratase/isomerase Anae109_3860 130 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 153007113 Nonpathogen - NnrS family protein Anae109_4276 1 COG3213 NnrS, Uncharacterized protein involved in response to NO Inorganic ion transport and metabolism 153005809 Common - protein of unknown function UPF0126 Anae109_2951 124 COG2860 COG2860, Predicted membrane protein Function unknown 153003067 Nonpathogen - mucin-associated surface protein (MASP), putative Anae109_0190 1 None None None 153007053 Common - ATP phosphoribosyltransferase Anae109_4216 211 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 153004314 Common - protein of unknown function DUF81 Anae109_1448 54 COG0730 COG0730, Predicted permeases General function prediction only 153005187 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Anae109_2326 120 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 153005868 Common - DnaK-related protein Anae109_3012 20 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 153004496 Common - hypothetical protein Anae109_1633 17 None None None 153007334 Common - ATP synthase F1, alpha subunit Anae109_4497 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 153005896 Common - glycosyl transferase, WecB/TagA/CpsF family Anae109_3040 91 COG1922 WecG, Teichoic acid biosynthesis proteins Cell envelope biogenesis, outer membrane 153004401 Common - ABC transporter related Anae109_1536 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 153005237 Nonpathogen - hypothetical protein Anae109_2376 1 None None None 153005763 Common - histidine kinase Anae109_2904 220 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 153003104 Common - gamma-glutamyl phosphate reductase Anae109_0227 187 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 153004290 Common - glycosyl transferase group 1 Anae109_1424 161 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153005073 Common - Indigoidine synthase A family protein Anae109_2212 49 COG2313 IndA, Uncharacterized enzyme involved in pigment biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 153005630 Common - DNA topoisomerase VI, B subunit Anae109_2771 34 COG1389 COG1389, DNA topoisomerase VI, subunit B DNA replication, recombination, and repair 153003119 Common - Cytochrome b/b6 domain Anae109_0242 149 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 153005137 Nonpathogen - hypothetical protein Anae109_2276 1 COG2210 COG2210, Uncharacterized conserved protein Function unknown 153003511 Common - iron-sulfur cluster assembly accessory protein Anae109_0639 161 COG0316 IscA, Uncharacterized conserved protein Function unknown 153003242 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Anae109_0368 184 COG2876 AroA, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 153004931 Nonpathogen - hypothetical protein Anae109_2069 2 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 153005049 Common - PAS/PAC sensor signal transduction histidine kinase Anae109_2188 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153005462 Common - succinate dehydrogenase or fumarate reductase cytochrome b subunit, b558 family Anae109_2602 31 None None None 153003434 Common - Alcohol dehydrogenase GroES domain protein Anae109_0561 203 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 153006799 Nonpathogen - hypothetical protein Anae109_3962 1 None None None 153005337 Common - Acetyl-CoA hydrolase Anae109_2477 94 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 153006448 Common - cysteine synthase Anae109_3608 221 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 153005035 Nonpathogen - hypothetical protein Anae109_2174 2 None None None 153006156 Nonpathogen - hypothetical protein Anae109_3312 2 None None None 153003800 Nonpathogen - hypothetical protein Anae109_0932 14 COG4641 COG4641, Uncharacterized protein conserved in bacteria Function unknown 153003771 Common - FeS assembly protein SufB Anae109_0903 184 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 153003863 Nonpathogen - LigA Anae109_0995 1 None None None 153006073 Common - oxidoreductase domain protein Anae109_3219 122 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 153007185 Common - NADH-quinone oxidoreductase, F subunit Anae109_4348 166 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 153005036 Common - PBS lyase HEAT domain protein repeat-containing protein Anae109_2175 24 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 153007033 Common - NAD-dependent epimerase/dehydratase Anae109_4196 232 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153005750 Common - Excinuclease ABC C subunit domain protein Anae109_2891 68 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 153007115 Common - glycine cleavage H-protein Anae109_4278 77 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 153006392 Common - DNA polymerase III, alpha subunit Anae109_3552 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 153007308 Common - Tetratricopeptide TPR_4 Anae109_4471 11 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 153002987 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_0110 170 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153006291 Common - peptidase M23B Anae109_3448 188 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 153004433 Common - OmpA/MotB domain protein Anae109_1570 173 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 153005772 Common - DEAD/DEAH box helicase domain protein Anae109_2913 239 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 153003447 Common - Ppx/GppA phosphatase Anae109_0574 179 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 153003286 Common - putative RNA methylase Anae109_0412 126 COG0116 COG0116, Predicted N6-adenine-specific DNA methylase DNA replication, recombination, and repair 153003993 Nonpathogen - protein of unknown function DUF167 Anae109_1126 1 COG1872 COG1872, Uncharacterized conserved protein Function unknown 153005905 Common - cytochrome C family protein Anae109_3049 25 None None None 153006497 Common - alpha/beta hydrolase fold Anae109_3658 155 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153003703 Common - ATP-dependent helicase HrpB Anae109_0833 131 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 153003204 Common - glycosyl transferase group 1 Anae109_0330 131 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153006289 Common - ABC transporter related Anae109_3446 234 COG1119 ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA Inorganic ion transport and metabolism 153006740 Nonpathogen - hypothetical protein Anae109_3902 1 None None None 153005927 Common - hypothetical protein Anae109_3072 65 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 153005402 Nonpathogen - hypothetical protein Anae109_2542 1 None None None 153006684 Common - Pyridoxal-5'-phosphate-dependent protein beta subunit Anae109_3846 223 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 153005505 Common - hypothetical protein Anae109_2645 21 None None None 153005830 Common - pyridine nucleotide transhydrogenase alpha subunit-like protein Anae109_2972 117 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 153004168 Common - putative transposase Anae109_1301 28 None None None 153003221 Common - nucleoside recognition domain protein Anae109_0347 37 COG2715 SpmA, Uncharacterized membrane protein, required for spore maturation in B.subtilis. General function prediction only 153006377 Nonpathogen - putative CheW protein Anae109_3537 3 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153003859 Common - major facilitator superfamily MFS_1 Anae109_0991 168 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153004338 Common - chaperonin GroEL Anae109_1472 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 153005152 Common - signal peptide peptidase SppA, 36K type Anae109_2291 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 153005200 Common - tRNA(Ile)-lysidine synthetase Anae109_2339 108 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 153003597 Nonpathogen - hypothetical protein Anae109_0725 1 COG4967 PilV, Tfp pilus assembly protein PilV Cell motility and secretion / Intracellular trafficking and secretion 153006276 Common - twitching motility protein Anae109_3433 151 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 153006085 Common - transcriptional regulator, LysR family Anae109_3231 185 COG0583 LysR, Transcriptional regulator Transcription 153005167 Nonpathogen - hypothetical protein Anae109_2306 8 None None None 153004320 Common - inner-membrane translocator Anae109_1454 150 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 153007167 Common - beta-lactamase domain protein Anae109_4330 19 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 153007241 Common - short-chain dehydrogenase/reductase SDR Anae109_4404 234 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153006715 Nonpathogen - hypothetical protein Anae109_3877 3 COG3116 FtsL, Cell division protein Cell division and chromosome partitioning 153006958 Common - protein-L-isoaspartate O-methyltransferase Anae109_4121 157 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 153003660 Common - peptidase M23B Anae109_0789 189 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 153006164 Common - ATPase AAA-2 domain protein Anae109_3321 215 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 153007166 Nonpathogen - hypothetical protein Anae109_4329 1 None None None 153005729 Nonpathogen - hypothetical protein Anae109_2870 3 None None None 153007230 Nonpathogen - membrane protein Anae109_4393 1 COG4872 COG4872, Predicted membrane protein Function unknown 153004409 Common - protein of unknown function DUF378 Anae109_1545 7 COG2155 COG2155, Uncharacterized conserved protein Function unknown 153005373 Common - phosphoribosylglycinamide formyltransferase Anae109_2513 217 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 153004838 Common - protein of unknown function DUF140 Anae109_1976 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 153004558 Common - binding-protein-dependent transport systems inner membrane component Anae109_1695 144 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 153005882 Common - nitrogen fixation protein NifX Anae109_3026 32 COG1433 COG1433, Uncharacterized conserved protein Function unknown 153005987 Common - transcriptional regulator, TraR/DksA family Anae109_3132 31 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 153004030 Common - NUDIX hydrolase Anae109_1163 70 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 153005488 Common - glycosyl transferase group 1 Anae109_2628 192 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153004885 Nonpathogen - hypothetical protein Anae109_2023 2 COG3255 COG3255, Putative sterol carrier protein Lipid metabolism 153005549 Common - tyrosine recombinase XerC Anae109_2689 225 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 153006266 Nonpathogen - hypothetical protein Anae109_3423 2 None None None 153004299 Common - protein kinase Anae109_1433 147 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153003640 Nonpathogen - heat shock protein DnaJ domain protein Anae109_0769 4 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 153007024 Common - ATPase AAA-2 domain protein Anae109_4187 218 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 153004572 Common - type I topoisomerase Anae109_1709 44 COG3569 COG3569, Topoisomerase IB DNA replication, recombination, and repair 153004710 Common - RNA polymerase sigma factor RpoH Anae109_1848 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 153006051 Common - Cystathionine gamma-synthase Anae109_3196 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 153007224 Nonpathogen - hypothetical protein Anae109_4387 1 None None None 153005400 Common - peptidase M23B Anae109_2540 191 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 153006676 Common - metallophosphoesterase Anae109_3838 38 COG1409 Icc, Predicted phosphohydrolases General function prediction only 153004790 Common - ribosomal protein S5 Anae109_1928 243 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 153004058 Common - metallophosphoesterase Anae109_1191 109 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 153006230 Common - hypothetical protein Anae109_3387 4 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 153003788 Common - peptidase M20 Anae109_0920 165 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 153004085 Common - cytochrome c oxidase subunit I Anae109_1218 146 COG3278 CcoN, Cbb3-type cytochrome oxidase, subunit 1 Posttranslational modification, protein turnover, chaperones 153005819 Common - ABC transporter related Anae109_2961 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 153005283 Common - protein of unknown function DUF323 Anae109_2423 99 COG1262 COG1262, Uncharacterized conserved protein Function unknown 153006742 Common - alanyl-tRNA synthetase Anae109_3904 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153005833 Common - protein of unknown function DUF1486 Anae109_2975 26 COG5485 COG5485, Predicted ester cyclase General function prediction only 153006009 Common - Rubrerythrin Anae109_3154 78 COG1592 COG1592, Rubrerythrin Energy production and conversion 153003173 Common - Fmu (Sun) domain protein Anae109_0298 206 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 153003725 Common - glutamate synthase, NADH/NADPH, small subunit Anae109_0855 197 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 153004230 Nonpathogen - hypothetical protein Anae109_1364 2 None None None 153005435 Common - protein of unknown function DUF343 Anae109_2575 58 COG2835 COG2835, Uncharacterized conserved protein Function unknown 153003347 Common - thioredoxin reductase Anae109_0473 245 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 153005217 Common - PAS/PAC sensor hybrid histidine kinase Anae109_2356 220 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 153004236 Common - Peptidoglycan glycosyltransferase Anae109_1370 198 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 153004483 Common - hypothetical protein Anae109_1620 6 None None None 153005887 Common - GCN5-related N-acetyltransferase Anae109_3031 15 COG0456 RimI, Acetyltransferases General function prediction only 153004488 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Anae109_1625 152 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 153004621 Common - Na+ symporter Anae109_1759 144 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 153005569 Common - apolipoprotein N-acyltransferase Anae109_2709 133 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 153004265 Common - phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Anae109_1399 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 153004953 Nonpathogen - hypothetical protein Anae109_2091 1 None None None 153003071 Common - hypothetical protein Anae109_0194 9 COG3248 Tsx, Nucleoside-binding outer membrane protein Cell envelope biogenesis, outer membrane 153003687 Common - putative CBS domain and cyclic nucleotide-regulated nucleotidyltransferase Anae109_0817 107 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 153003110 Common - protein of unknown function DUF86 Anae109_0233 37 COG2361 COG2361, Uncharacterized conserved protein Function unknown 153005024 Common - acyl-CoA dehydrogenase domain protein Anae109_2163 162 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 153006301 Common - UDP-N-acetylmuramate Anae109_3458 207 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 153006652 Common - response regulator receiver protein Anae109_3814 223 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153006859 Common - metal dependent phosphohydrolase Anae109_4022 56 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 153004326 Common - Phosphatidylinositol alpha-mannosyltransferase Anae109_1460 119 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153005120 Common - histidine kinase Anae109_2259 17 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153006666 Common - Na+/H+ antiporter NhaA Anae109_3828 106 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 153004965 Nonpathogen - hypothetical protein Anae109_2103 1 None None None 153004980 Common - peptidase M50 Anae109_2118 84 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 153003711 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_0841 137 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153005259 Nonpathogen - hypothetical protein Anae109_2398 2 None None None 153005642 Common - domain of unknown function DUF1730 Anae109_2783 137 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 153003746 Common - ABC transporter related Anae109_0878 227 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 153005597 Common - 3-oxoacyl-(acyl-carrier-protein) reductase Anae109_2737 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153004639 Nonpathogen - TPR repeat-containing protein Anae109_1777 4 COG4105 ComL, DNA uptake lipoprotein General function prediction only 153002979 Common - adenosine deaminase Anae109_0100 114 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 153003573 Nonpathogen - Methyltransferase type 11 Anae109_0701 2 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153004115 Common - NAD+ synthetase Anae109_1248 207 COG0171 NadE, NAD synthase Coenzyme metabolism 153003132 Nonpathogen - hypothetical protein Anae109_0255 1 None None None 153003498 Nonpathogen - hypothetical protein Anae109_0626 1 None None None 153004240 Common - Glutamyl-tRNA reductase Anae109_1374 179 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 153005649 Common - sodium:dicarboxylate symporter Anae109_2790 154 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 153004491 Nonpathogen - hypothetical protein Anae109_1628 2 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 153003897 Nonpathogen - UspA domain protein Anae109_1029 2 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 153005733 Common - methyl-accepting chemotaxis sensory transducer Anae109_2874 89 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153006027 Common - Xanthine phosphoribosyltransferase Anae109_3172 51 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 153004133 Nonpathogen - peptidase M10A and M12B matrixin and adamalysin Anae109_1266 4 COG1913 COG1913, Predicted Zn-dependent proteases General function prediction only 153003194 Common - Glutamate--tRNA ligase Anae109_0319 231 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 153006076 Common - Methyltransferase type 12 Anae109_3222 123 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 153004775 Common - Ribosomal protein L25/L23 Anae109_1913 213 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 153006764 Common - single-strand binding protein Anae109_3926 215 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 153004099 Nonpathogen - conserved hypothetical cytosolic protein Anae109_1232 4 None None None 153005242 Nonpathogen - outer membrane efflux protein Anae109_2381 2 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 153004887 Common - transketolase Anae109_2025 221 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 153002970 Common - protein of unknown function DUF853 NPT hydrolase putative Anae109_0091 77 COG0433 COG0433, Predicted ATPase General function prediction only 153004025 Common - metal dependent phosphohydrolase Anae109_1158 124 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 153005681 Common - ABC-type nitrate/sulfonate/bicarbonate transporter, periplasmic ligand binding protein Anae109_2822 45 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 153006732 Common - cell division protein FtsZ Anae109_3894 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 153003041 Common - NUDIX hydrolase Anae109_0164 82 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 153005130 Common - tRNA-pseudouridine synthase I Anae109_2269 222 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 153007191 Common - amidophosphoribosyltransferase Anae109_4354 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 153004923 Common - alpha/beta hydrolase fold Anae109_2061 119 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153005159 Common - response regulator receiver modulated CheB methylesterase Anae109_2298 196 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 153004251 Common - two component transcriptional regulator, LuxR family Anae109_1385 221 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 153004874 Nonpathogen - hypothetical protein Anae109_2012 1 None None None 153005687 Common - Cupin 2 conserved barrel domain protein Anae109_2828 37 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 153005722 Nonpathogen - caa(3)-type oxidase, subunit IV Anae109_2863 1 None None None 153003157 Common - biotin/lipoyl attachment domain-containing protein Anae109_0280 164 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 153003264 Common - MaoC-like dehydratase Anae109_0390 25 COG2030 MaoC, Acyl dehydratase Lipid metabolism 153006034 Common - cyclic nucleotide-binding protein Anae109_3179 60 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 153006612 Nonpathogen - PEGA domain protein Anae109_3774 4 None None None 153003188 Common - hypothetical protein Anae109_0313 27 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 153005613 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_2754 35 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 153003964 Common - protein kinase Anae109_1097 123 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153003750 Nonpathogen - hypothetical protein Anae109_0882 1 None None None 153004172 Common - response regulator receiver protein Anae109_1305 211 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153004458 Common - transcriptional regulator, LysR family Anae109_1595 184 COG0583 LysR, Transcriptional regulator Transcription 153003380 Common - Amidase Anae109_0507 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 153003466 Nonpathogen - hypothetical protein Anae109_0593 1 None None None 153002960 Common - peptidase M16 domain protein Anae109_0081 182 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 153006582 Common - phosphatidylglycerophosphatase A Anae109_3744 103 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 153006316 Common - Class I peptide chain release factor Anae109_3473 127 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 153006370 Nonpathogen - hypothetical protein Anae109_3530 3 None None None 153007318 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Anae109_4481 162 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 153006469 Common - hypothetical protein Anae109_3629 28 COG4117 COG4117, Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) Energy production and conversion 153006957 Common - Radical SAM domain protein Anae109_4120 98 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 153005580 Common - asparaginyl-tRNA synthetase Anae109_2720 249 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 153006866 Common - Exonuclease RNase T and DNA polymerase III Anae109_4029 143 COG2176 PolC, DNA polymerase III, alpha subunit (gram-positive type) DNA replication, recombination, and repair 153002950 Common - dethiobiotin synthase Anae109_0071 146 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 153003293 Common - phosphate ABC transporter, inner membrane subunit PstC Anae109_0419 225 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 153004828 Common - protein of unknown function DUF1458 Anae109_1966 47 COG3360 COG3360, Uncharacterized conserved protein Function unknown 153006429 Common - iron-sulfur cluster assembly accessory protein Anae109_3589 166 COG0316 IscA, Uncharacterized conserved protein Function unknown 153006600 Common - DNA polymerase III, subunits gamma and tau Anae109_3762 247 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 153006388 Common - APHP domain protein Anae109_3548 70 COG1572 COG1572, Uncharacterized conserved protein Function unknown 153005175 Common - phosphatidylserine decarboxylase Anae109_2314 91 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 153006949 Common - sigma54 specific transcriptional regulator, Fis family Anae109_4112 173 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 153004817 Common - ATP-binding protein Anae109_1955 93 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 153002887 Common - Haloalkane dehalogenase Anae109_0008 112 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153004413 Common - protein kinase Anae109_1549 146 COG5616 COG5616, Predicted integral membrane protein Function unknown 153006323 Common - protein of unknown function DUF482 Anae109_3481 81 COG3146 COG3146, Uncharacterized protein conserved in bacteria Function unknown 153004808 Nonpathogen - hypothetical protein Anae109_1946 2 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 153004994 Nonpathogen - hypothetical protein Anae109_2132 1 None None None 153002957 Common - replicative DNA helicase Anae109_0078 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 153006346 Common - Hemerythrin HHE cation binding domain protein Anae109_3504 27 COG5592 COG5592, Uncharacterized conserved protein Function unknown 153006554 Nonpathogen - hypothetical protein Anae109_3716 1 None None None 153004296 Nonpathogen - hypothetical protein Anae109_1430 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 153007215 Common - phosphate transporter Anae109_4378 171 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 153003008 Common - hypoxanthine phosphoribosyltransferase Anae109_0131 151 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 153005589 Common - 3,4-dihydroxy-2-butanone 4-phosphate synthase Anae109_2729 230 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 153003984 Common - lysyl-tRNA synthetase Anae109_1117 247 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 153003809 Common - MscS Mechanosensitive ion channel Anae109_0941 159 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 153004374 Common - type IV pilus assembly PilZ Anae109_1508 7 COG3215 PilZ, Tfp pilus assembly protein PilZ Cell motility and secretion / Intracellular trafficking and secretion 153006174 Common - Carbohydrate binding family 6 Anae109_3331 9 None None None 153004563 Common - HNH endonuclease Anae109_1700 5 COG1403 McrA, Restriction endonuclease Defense mechanisms 153005962 Nonpathogen - LigA Anae109_3107 1 None None None 153006820 Common - hypothetical protein Anae109_3983 30 COG3440 COG3440, Predicted restriction endonuclease Defense mechanisms 153006422 Common - multi-sensor signal transduction histidine kinase Anae109_3582 223 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153005700 Common - Carbonate dehydratase Anae109_2841 152 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 153004375 Common - (Uracil-5)-methyltransferase Anae109_1509 196 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 153005865 Common - putative ribonuclease BN Anae109_3009 121 COG1295 Rbn, Predicted membrane protein Function unknown 153006107 Common - short-chain dehydrogenase/reductase SDR Anae109_3255 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153003602 Common - general secretion pathway protein D Anae109_0730 138 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 153005394 Nonpathogen - hypothetical protein Anae109_2534 1 None None None 153006401 Common - 8-amino-7-oxononanoate synthase Anae109_3561 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 153006473 Common - glycosyltransferase Anae109_3633 25 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 153003538 Common - riboflavin biosynthesis protein RibF Anae109_0666 210 COG0196 RibF, FAD synthase Coenzyme metabolism 153004836 Common - pseudouridine synthase Anae109_1974 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 153004112 Nonpathogen - hypothetical protein Anae109_1245 1 None None None 153003696 Common - CBS domain containing protein Anae109_0826 218 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 153003128 Nonpathogen - Fe-S oxidoreductase Anae109_0251 2 COG3170 FimV, Tfp pilus assembly protein FimV Cell motility and secretion / Intracellular trafficking and secretion 153004536 Nonpathogen - blue (type 1) copper domain Anae109_1673 1 None None None 153006355 Common - CDP-alcohol phosphatidyltransferase Anae109_3513 21 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 153007311 Common - chaperone protein DnaK Anae109_4474 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 153004782 Common - ribosomal protein S17 Anae109_1920 228 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 153003121 Common - Nitrous-oxide reductase Anae109_0244 45 COG4263 NosZ, Nitrous oxide reductase Energy production and conversion 153006049 Common - Extradiol ring-cleavage dioxygenase class III protein subunit B Anae109_3194 86 COG3384 COG3384, Uncharacterized conserved protein Function unknown 153004668 Common - deca-heme C-type cytochrome-like protein Anae109_1806 25 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 153004703 Nonpathogen - hypothetical protein Anae109_1841 1 None None None 153003678 Common - dihydroorotate dehydrogenase Anae109_0808 86 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 153005297 Common - putative signal transduction protein with CBS domains Anae109_2437 183 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 153007259 Common - ATPase associated with various cellular activities AAA_3 Anae109_4422 172 COG0714 COG0714, MoxR-like ATPases General function prediction only 153006126 Common - response regulator receiver protein Anae109_3277 212 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153007082 Common - aminotransferase class I and II Anae109_4245 236 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 153005407 Common - hypothetical protein Anae109_2547 39 None None None 153004985 Nonpathogen - PBS lyase HEAT domain protein repeat-containing protein Anae109_2123 1 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 153006846 Nonpathogen - hypothetical protein Anae109_4009 1 None None None 153007065 Nonpathogen - hypothetical protein Anae109_4228 13 COG3541 COG3541, Predicted nucleotidyltransferase General function prediction only 153004478 Common - protein of unknown function DUF191 Anae109_1615 39 COG2107 COG2107, Predicted periplasmic solute-binding protein General function prediction only 153004444 Common - conserved hypothetical cytosolic protein Anae109_1581 25 None None None 153004855 Common - 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) Anae109_1993 154 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 153003093 Common - CoA-binding domain protein Anae109_0216 110 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 153007277 Common - NAD-dependent epimerase/dehydratase Anae109_4440 231 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153004552 Nonpathogen - hypothetical protein Anae109_1689 6 None None None 153003653 Common - CBS domain containing protein Anae109_0782 130 COG0517 COG0517, FOG: CBS domain General function prediction only 153005517 Nonpathogen - hypothetical protein Anae109_2657 1 None None None 153005054 Common - aspartate carbamoyltransferase Anae109_2193 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 153005742 Nonpathogen - hypothetical protein Anae109_2883 2 None None None 153006629 Nonpathogen - HNH endonuclease Anae109_3791 5 COG1403 McrA, Restriction endonuclease Defense mechanisms 153003606 Common - transcription termination factor Rho Anae109_0734 206 COG1158 Rho, Transcription termination factor Transcription 153006752 Common - response regulator receiver protein Anae109_3914 8 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 153006173 Common - trehalose synthase Anae109_3330 8 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 153005552 Common - transcriptional regulator, TraR/DksA family Anae109_2692 6 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 153006978 Common - diguanylate cyclase Anae109_4141 185 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153003738 Common - TonB family protein Anae109_0870 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 153005956 Common - amino acid transporter-like protein Anae109_3101 46 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 153005924 Common - response regulator receiver protein Anae109_3069 143 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153006977 Common - protein of unknown function DUF72 Anae109_4140 76 COG1801 COG1801, Uncharacterized conserved protein Function unknown 153005048 Common - YdjC family protein Anae109_2187 13 COG3394 COG3394, Uncharacterized protein conserved in bacteria Function unknown 153005050 Nonpathogen - hypothetical protein Anae109_2189 1 COG1259 COG1259, Uncharacterized conserved protein Function unknown 153004063 Common - hypothetical protein Anae109_1196 8 None None None 153004259 Common - peptidase U62 modulator of DNA gyrase Anae109_1393 161 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 153006587 Common - hypothetical protein Anae109_3749 19 None None None 153003355 Common - alpha/beta hydrolase fold Anae109_0481 141 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153004037 Common - excinuclease ABC, A subunit Anae109_1170 242 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 153005618 Common - cytochrome c class I Anae109_2759 38 COG3474 COG3474, Cytochrome c2 Energy production and conversion 153003162 Nonpathogen - hypothetical protein Anae109_0285 3 None None None 153007184 Common - NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Anae109_4347 130 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 153005636 Common - methionine-R-sulfoxide reductase Anae109_2777 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 153005068 Nonpathogen - hypothetical protein Anae109_2207 1 None None None 153007075 Common - MaoC domain protein dehydratase Anae109_4238 80 COG2030 MaoC, Acyl dehydratase Lipid metabolism 153004843 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Anae109_1981 159 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 153003017 Nonpathogen - hypothetical protein Anae109_0140 1 None None None 153003899 Nonpathogen - hypothetical protein Anae109_1031 1 None None None 153004590 Common - Rieske (2Fe-2S) domain protein Anae109_1727 79 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 153005959 Common - two component transcriptional regulator, winged helix family Anae109_3104 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153005707 Common - transcriptional regulator, LysR family Anae109_2848 187 COG0583 LysR, Transcriptional regulator Transcription 153004622 Common - Tryptophanase Anae109_1760 45 COG3033 TnaA, Tryptophanase Amino acid transport and metabolism 153006561 Common - succinyl-CoA synthetase, alpha subunit Anae109_3723 217 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 153004203 Common - FAD dependent oxidoreductase Anae109_1336 157 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 153003488 Common - phenazine biosynthesis protein PhzF family Anae109_0616 113 COG0384 COG0384, Predicted epimerase, PhzC/PhzF homolog General function prediction only 153004901 Common - Prephenate dehydratase Anae109_2039 212 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 153006192 Common - hypothetical protein Anae109_3349 11 None None None 153004090 Nonpathogen - hypothetical protein Anae109_1223 5 COG5456 COG5456, Predicted integral membrane protein linked to a cation pump Inorganic ion transport and metabolism 153003877 Nonpathogen - hypothetical protein Anae109_1009 1 None None None 153003554 Common - peptidase A24A domain protein Anae109_0682 111 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 153003327 Nonpathogen - histidine kinase HAMP region domain protein Anae109_0453 3 None None None 153005248 Common - histidine kinase Anae109_2387 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153006032 Nonpathogen - hypothetical protein Anae109_3177 1 None None None 153004242 Common - Uroporphyrinogen III synthase HEM4 Anae109_1376 41 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 153005096 Common - multi-sensor signal transduction histidine kinase Anae109_2235 224 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153003874 Nonpathogen - protein of unknown function DUF1469 Anae109_1006 1 None None None 153002909 Common - integral membrane sensor signal transduction histidine kinase Anae109_0030 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153002982 Common - hypothetical protein Anae109_0103 10 None None None 153004383 Common - RNA modification enzyme, MiaB family Anae109_1518 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 153004986 Nonpathogen - Secretin/TonB short domain Anae109_2124 3 COG1283 NptA, Na+/phosphate symporter Inorganic ion transport and metabolism 153006810 Nonpathogen - hypothetical protein Anae109_3973 2 None None None 153006186 Common - peptidase M24 Anae109_3343 225 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 153005602 Common - protein of unknown function DUF177 Anae109_2742 49 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 153007316 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Anae109_4479 66 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 153004332 Common - ATPase AAA-2 domain protein Anae109_1466 215 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 153003562 Common - type IV pilus secretin PilQ Anae109_0690 142 COG4796 HofQ, Type II secretory pathway, component HofQ Intracellular trafficking and secretion 153005811 Common - GtrA family protein Anae109_2953 25 COG2246 COG2246, Predicted membrane protein Function unknown 153003555 Common - integral membrane sensor signal transduction histidine kinase Anae109_0683 190 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153006238 Nonpathogen - hypothetical protein Anae109_3395 3 None None None 153005154 Nonpathogen - putative CheW protein Anae109_2293 10 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153002914 Common - membrane protein involved in aromatic hydrocarbon degradation Anae109_0035 70 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 153005016 Common - small GTP-binding protein Anae109_2155 231 COG1160 COG1160, Predicted GTPases General function prediction only 153002938 Common - pseudouridine synthase, RluA family Anae109_0059 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 153006709 Common - hypothetical protein Anae109_3871 6 None None None 153003959 Nonpathogen - hypothetical protein Anae109_1092 1 None None None 153004231 Common - alanine racemase domain protein Anae109_1365 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 153003627 Common - imidazole glycerol phosphate synthase, glutamine amidotransferase subunit Anae109_0755 217 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 153003970 Common - Patatin Anae109_1103 3 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 153005906 Common - aldo/keto reductase Anae109_3050 205 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 153006108 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Anae109_3256 62 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 153003303 Common - ABC transporter related Anae109_0429 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 153003513 Common - Fe-S protein assembly chaperone HscA Anae109_0641 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 153006218 Common - dTMP kinase Anae109_3375 178 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 153005471 Common - DegT/DnrJ/EryC1/StrS aminotransferase Anae109_2611 160 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 153006133 Nonpathogen - hypothetical protein Anae109_3285 3 None None None 153003024 Common - hypothetical protein Anae109_0147 9 None None None 153003681 Common - Rubrerythrin Anae109_0811 79 COG1592 COG1592, Rubrerythrin Energy production and conversion 153006714 Common - S-adenosyl-methyltransferase MraW Anae109_3876 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 153006919 Common - isopentenyl-diphosphate delta-isomerase, type 2 Anae109_4082 80 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 153006914 Nonpathogen - hypothetical protein Anae109_4077 1 None None None 153007283 Nonpathogen - hypothetical protein Anae109_4446 2 None None None 153004742 Common - translation initiation factor IF-3 Anae109_1880 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 153003978 Nonpathogen - hypothetical protein Anae109_1111 1 None None None 153004146 Common - proton-translocating NADH-quinone oxidoreductase, chain N Anae109_1279 210 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 153004183 Common - lysine 2,3-aminomutase YodO family protein Anae109_1316 125 COG1509 KamA, Lysine 2,3-aminomutase Amino acid transport and metabolism 153003632 Common - DNA primase Anae109_0761 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 153007234 Common - nitrogen regulatory protein P-II Anae109_4397 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 153002931 Common - Integral membrane protein TerC Anae109_0052 112 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 153003884 Common - integral membrane sensor signal transduction histidine kinase Anae109_1016 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153006790 Common - phosphoribosylformylglycinamidine synthase, purS Anae109_3953 111 COG1828 PurS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component Nucleotide transport and metabolism 153004699 Common - cytochrome C family protein Anae109_1837 25 None None None 153007256 Common - glycoside hydrolase family 3 domain protein Anae109_4419 177 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 153006201 Common - ketosteroid isomerase-related protein-like protein Anae109_3358 15 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 153006505 Nonpathogen - GYD family protein Anae109_3666 7 COG4274 COG4274, Uncharacterized conserved protein Function unknown 153003753 Common - short-chain dehydrogenase/reductase SDR Anae109_0885 224 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 153005162 Common - ribosomal protein S1 Anae109_2301 231 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 153002966 Common - methionine synthase Anae109_0087 178 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 153005230 Nonpathogen - putative CheW protein Anae109_2369 1 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153006982 Common - phospholipid/glycerol acyltransferase Anae109_4145 24 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 153006837 Common - metallophosphoesterase Anae109_4000 5 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 153003066 Common - putative CoA-substrate-specific enzyme activase Anae109_0189 59 COG1924 COG1924, Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) Lipid metabolism 153004368 Common - band 7 protein Anae109_1502 211 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 153005061 Common - DNA polymerase III, alpha subunit Anae109_2200 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 153003099 Common - hypothetical protein Anae109_0222 12 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 153005313 Common - DivIVA family protein Anae109_2453 36 COG3599 DivIVA, Cell division initiation protein Cell division and chromosome partitioning 153006632 Nonpathogen - hypothetical protein Anae109_3794 1 None None None 153005608 Common - glutamate synthase (NADPH), homotetrameric Anae109_2748 212 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 153003623 Common - protein of unknown function DUF1704 Anae109_0751 16 COG3930 COG3930, Uncharacterized protein conserved in bacteria Function unknown 153006283 Common - UvrD/REP helicase Anae109_3440 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 153005789 Common - 2-amino-3-ketobutyrate coenzyme A ligase Anae109_2930 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 153004940 Common - threonine synthase Anae109_2078 132 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 153004462 Common - major facilitator superfamily MFS_1 Anae109_1599 95 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 153005192 Common - carbohydrate kinase, YjeF related protein Anae109_2331 166 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 153007193 Common - thioesterase superfamily protein Anae109_4356 17 COG0824 FcbC, Predicted thioesterase General function prediction only 153004670 Nonpathogen - hypothetical protein Anae109_1808 1 None None None 153005515 Nonpathogen - hypothetical protein Anae109_2655 1 None None None 153006639 Common - RNA binding S1 domain protein Anae109_3801 215 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 153005673 Common - hypothetical protein Anae109_2814 7 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 153007292 Common - MotA/TolQ/ExbB proton channel Anae109_4455 67 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 153004818 Common - heat shock protein DnaJ domain protein Anae109_1956 28 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 153006402 Common - biotin synthase Anae109_3562 185 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 153007003 Common - ABC transporter related Anae109_4166 249 COG4586 COG4586, ABC-type uncharacterized transport system, ATPase component General function prediction only 153002961 Common - peptidase M16 domain protein Anae109_0082 160 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 153006242 Common - sigma54 specific transcriptional regulator, Fis family Anae109_3399 182 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 153006382 Nonpathogen - hypothetical protein Anae109_3542 6 None None None 153003234 Nonpathogen - formylmethanofuran dehydrogenase subunit E region Anae109_0360 15 COG2191 COG2191, Formylmethanofuran dehydrogenase subunit E Energy production and conversion 153003946 Nonpathogen - hypothetical protein Anae109_1079 1 None None None 153006327 Common - homogentisate 12-dioxygenase Anae109_3485 51 COG3508 HmgA, Homogentisate 1,2-dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 153003910 Common - cation transporter Anae109_1042 150 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 153007307 Common - peptidase M50 Anae109_4470 38 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 153006593 Common - Uracil-DNA glycosylase superfamily Anae109_3755 116 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 153003861 Common - Holliday junction DNA helicase RuvA Anae109_0993 201 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 153003885 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_1017 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153003526 Common - putative CheW protein Anae109_0654 88 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153005974 Nonpathogen - hypothetical protein Anae109_3119 1 None None None 153005376 Nonpathogen - hypothetical protein Anae109_2516 7 None None None 153004473 Nonpathogen - hypothetical protein Anae109_1610 1 None None None 153006146 Nonpathogen - transposase, IS4 Anae109_3298 4 None None None 153004511 Nonpathogen - Hemerythrin HHE cation binding domain protein Anae109_1648 1 None None None 153006449 Common - Pyridoxal-5'-phosphate-dependent protein beta subunit Anae109_3609 226 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 153005793 Common - histidine kinase Anae109_2934 48 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153005240 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_2379 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153007123 Common - exporters of the RND superfamily Anae109_4286 10 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 153007107 Common - NUDIX hydrolase Anae109_4270 111 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 153003142 Nonpathogen - Cupin 2 conserved barrel domain protein Anae109_0265 8 COG4766 EutQ, Ethanolamine utilization protein Amino acid transport and metabolism 153006753 Nonpathogen - hypothetical protein Anae109_3915 1 None None None 153005457 Common - PAS/PAC sensor signal transduction histidine kinase Anae109_2597 220 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 153005971 Common - histidine kinase HAMP region domain protein Anae109_3116 21 COG2770 ResE, FOG: HAMP domain Signal transduction mechanisms 153005195 Common - phosphoglucosamine mutase Anae109_2334 243 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 153006696 Common - protein kinase Anae109_3858 140 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153006876 Common - Methyltransferase type 12 Anae109_4039 25 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153005655 Common - hypothetical protein Anae109_2796 9 None None None 153004892 Common - histidine kinase Anae109_2030 226 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 153003354 Common - orotidine 5'-phosphate decarboxylase Anae109_0480 152 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 153005834 Common - histidine kinase Anae109_2976 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153005960 Common - protein of unknown function RIO1 Anae109_3105 66 COG1718 RIO1, Serine/threonine protein kinase involved in cell cycle control Signal transduction mechanisms / Cell division and chromosome partitioning 153004278 Common - Undecaprenyl-phosphate galactose phosphotransferase Anae109_1412 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 153004585 Common - GAF sensor signal transduction histidine kinase Anae109_1722 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153007203 Common - superfamily I DNA and RNA helicase Anae109_4366 64 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 153007157 Nonpathogen - hypothetical protein Anae109_4320 1 None None None 153005446 Common - AMP-dependent synthetase and ligase Anae109_2586 222 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 153006228 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Anae109_3385 10 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 153004661 Nonpathogen - hypothetical protein Anae109_1799 3 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 153003700 Common - 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase Anae109_0830 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 153003501 Common - amine oxidase Anae109_0629 8 COG1232 HemY, Protoporphyrinogen oxidase Coenzyme metabolism 153004918 Common - Beta-lactamase Anae109_2056 42 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 153007286 Common - hypothetical protein Anae109_4449 18 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 153004459 Common - carbon starvation protein CstA Anae109_1596 109 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 153004613 Common - phospholipid/glycerol acyltransferase Anae109_1751 18 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 153004566 Common - Coproporphyrinogen oxidase Anae109_1703 113 COG0408 HemF, Coproporphyrinogen III oxidase Coenzyme metabolism 153005994 Common - Na+ symporter Anae109_3139 173 COG4147 DhlC, Predicted symporter General function prediction only 153004023 Common - phosphoglycolate phosphatase Anae109_1156 133 COG0546 Gph, Predicted phosphatases General function prediction only 153006646 Common - pantoate--beta-alanine ligase Anae109_3808 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 153006781 Common - aminotransferase class I and II Anae109_3944 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 153004345 Common - biotin--acetyl-CoA-carboxylase ligase Anae109_1479 224 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 153004673 Common - peptidase S8 and S53 subtilisin kexin sedolisin Anae109_1811 34 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 153005262 Common - queuine tRNA-ribosyltransferase Anae109_2402 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 153006606 Nonpathogen - hypothetical protein Anae109_3768 11 None None None 153005216 Common - putative signal-transduction protein with CBS domains Anae109_2355 114 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 153005324 Common - Tetratricopeptide TPR_2 repeat protein Anae109_2464 44 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153004899 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Anae109_2037 183 COG0546 Gph, Predicted phosphatases General function prediction only 153003275 Common - transcriptional coactivator/pterin dehydratase Anae109_0401 128 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 153003302 Common - binding-protein-dependent transport systems inner membrane component Anae109_0428 193 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 153006488 Nonpathogen - hypothetical protein Anae109_3649 3 None None None 153003117 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Anae109_0240 198 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 153003908 Common - PAS/PAC sensor hybrid histidine kinase Anae109_1040 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153004921 Nonpathogen - hypothetical protein Anae109_2059 1 None None None 153003767 Common - hypothetical protein Anae109_0899 10 None None None 153006098 Common - transaldolase Anae109_3246 110 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 153004524 Common - extracellular solute-binding protein family 1 Anae109_1661 28 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 153005338 Common - inositol monophosphatase Anae109_2478 181 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 153006988 Common - multi-sensor signal transduction histidine kinase Anae109_4151 221 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 153004382 Nonpathogen - hypothetical protein Anae109_1517 1 None None None 153004687 Common - Spermine synthase Anae109_1825 107 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 153005715 Nonpathogen - hypothetical protein Anae109_2856 12 COG2033 COG2033, Desulfoferrodoxin Energy production and conversion 153005788 Common - PAS/PAC sensor hybrid histidine kinase Anae109_2929 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153005718 Nonpathogen - hypothetical protein Anae109_2859 6 None None None 153002923 Common - Phosphate butyryltransferase Anae109_0044 123 COG0280 Pta, Phosphotransacetylase Energy production and conversion 153003755 Common - delta-1-pyrroline-5-carboxylate dehydrogenase Anae109_0887 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 153004785 Common - ribosomal protein L5 Anae109_1923 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 153003918 Common - Alcohol dehydrogenase zinc-binding domain protein Anae109_1050 163 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 153004548 Nonpathogen - Hemerythrin HHE cation binding domain protein Anae109_1685 1 COG3945 COG3945, Uncharacterized conserved protein Function unknown 153007226 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_4389 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153004263 Nonpathogen - putative transcriptional regulator, MerR family Anae109_1397 3 COG0789 SoxR, Predicted transcriptional regulators Transcription 153005491 Common - glycosyl transferase group 1 Anae109_2631 199 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153003255 Nonpathogen - hypothetical protein Anae109_0381 1 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 153004655 Common - Integral membrane protein TerC Anae109_1793 100 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 153005419 Common - Pirin domain protein Anae109_2559 145 COG1741 COG1741, Pirin-related protein General function prediction only 153005507 Common - cysteine synthase A Anae109_2647 219 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 153002976 Nonpathogen - hypothetical protein Anae109_0097 1 None None None 153007043 Common - Radical SAM domain protein Anae109_4206 81 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 153004114 Common - asparagine synthase (glutamine-hydrolyzing) Anae109_1247 188 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 153005330 Nonpathogen - hypothetical protein Anae109_2470 2 None None None 153003454 Common - CHRD domain containing protein Anae109_0581 19 COG4907 COG4907, Predicted membrane protein Function unknown 153004864 Nonpathogen - hypothetical protein Anae109_2002 2 None None None 153005661 Common - regulator of chromosome condensation RCC1 Anae109_2802 37 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 153006667 Nonpathogen - hypothetical protein Anae109_3829 1 None None None 153005561 Common - metallophosphoesterase Anae109_2701 26 None None None 153002892 Common - isoleucyl-tRNA synthetase Anae109_0013 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153003082 Common - shikimate 5-dehydrogenase Anae109_0205 203 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 153006822 Common - ATPase (AAA+ superfamily)-like protein Anae109_3985 35 COG1483 COG1483, Predicted ATPase (AAA+ superfamily) General function prediction only 153003583 Common - protein of unknown function DUF214 Anae109_0711 32 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 153003197 Common - Alcohol dehydrogenase GroES domain protein Anae109_0322 211 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 153004589 Common - Cupin 2 conserved barrel domain protein Anae109_1726 4 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 153006017 Common - Catalase Anae109_3162 126 COG0753 KatE, Catalase Inorganic ion transport and metabolism 153004423 Nonpathogen - hypothetical protein Anae109_1560 1 None None None 153006669 Common - cation antiporter (Na+/Ca2+) Anae109_3831 90 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 153002951 Common - hypothetical protein Anae109_0072 12 None None None 153004154 Common - NADH (or F420H2) dehydrogenase, subunit C Anae109_1287 179 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 153005103 Common - bacterioferritin Anae109_2242 104 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 153006660 Common - transport-associated Anae109_3822 13 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 153004570 Common - LemA family protein Anae109_1707 130 COG1704 LemA, Uncharacterized conserved protein Function unknown 153005842 Common - AMP-dependent synthetase and ligase Anae109_2984 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153006995 Nonpathogen - HNH endonuclease Anae109_4158 4 COG1403 McrA, Restriction endonuclease Defense mechanisms 153004656 Nonpathogen - hypothetical protein Anae109_1794 2 None None None 153006886 Common - urease, alpha subunit Anae109_4049 96 COG0804 UreC, Urea amidohydrolase (urease) alpha subunit Amino acid transport and metabolism 153006771 Common - NAD-dependent epimerase/dehydratase Anae109_3933 20 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153006845 Nonpathogen - hypothetical protein Anae109_4008 1 None None None 153006906 Common - UspA domain protein Anae109_4069 138 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 153004501 Common - sulfate ABC transporter, periplasmic sulfate-binding protein Anae109_1638 89 COG1613 Sbp, ABC-type sulfate transport system, periplasmic component Inorganic ion transport and metabolism 153003032 Nonpathogen - hypothetical protein Anae109_0155 2 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 153004238 Common - thioredoxin Anae109_1372 233 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 153003506 Nonpathogen - hypothetical protein Anae109_0634 1 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 153005176 Common - urocanate hydratase Anae109_2315 97 COG2987 HutU, Urocanate hydratase Amino acid transport and metabolism 153005401 Nonpathogen - hypothetical protein Anae109_2541 1 None None None 153003180 Common - ribosome recycling factor Anae109_0305 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 153006621 Common - NAD-dependent dehydrogenase subunit Anae109_3783 41 COG4237 HyfE, Hydrogenase 4 membrane component (E) Energy production and conversion 153003787 Nonpathogen - protein of unknown function DUF181 Anae109_0919 9 COG1944 COG1944, Uncharacterized conserved protein Function unknown 153005504 Nonpathogen - hypothetical protein Anae109_2644 6 None None None 153003222 Common - transglutaminase domain protein Anae109_0348 32 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 153004479 Common - dienelactone hydrolase Anae109_1616 124 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 153004995 Nonpathogen - dual specificity protein phosphatase Anae109_2133 12 COG2453 CDC14, Predicted protein-tyrosine phosphatase Signal transduction mechanisms 153005480 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_2620 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153006683 Common - Cystathionine gamma-lyase Anae109_3845 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 153006825 Common - protein of unknown function DUF1156 Anae109_3988 47 COG1743 COG1743, Adenine-specific DNA methylase containing a Zn-ribbon DNA replication, recombination, and repair 153004737 Common - 3-isopropylmalate dehydratase, large subunit Anae109_1875 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 153003665 Common - YbaK/prolyl-tRNA synthetase associated region Anae109_0795 28 COG2606 EbsC, Uncharacterized conserved protein Function unknown 153005877 Common - phosphonate ABC transporter, periplasmic phosphonate-binding protein Anae109_3021 100 COG3221 PhnD, ABC-type phosphate/phosphonate transport system, periplasmic component Inorganic ion transport and metabolism 153004026 Common - response regulator receiver protein Anae109_1159 161 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153007168 Common - hypothetical protein Anae109_4331 10 None None None 153006375 Common - response regulator receiver protein Anae109_3535 223 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153003598 Common - hypothetical protein Anae109_0726 4 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 153006543 Common - phosphatidate cytidylyltransferase Anae109_3705 210 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 153002913 Common - hypothetical protein Anae109_0034 8 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 153003808 Nonpathogen - hypothetical protein Anae109_0940 1 None None None 153007216 Common - Radical SAM domain protein Anae109_4379 193 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 153003672 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Anae109_0802 16 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 153004644 Common - 3-beta hydroxysteroid dehydrogenase/isomerase Anae109_1782 121 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153006748 Nonpathogen - transcriptional regulator, Fis family Anae109_3910 5 COG2901 Fis, Factor for inversion stimulation Fis, transcriptional activator Transcription / DNA replication, recombination, and repair 153005151 Common - histidine triad (HIT) protein Anae109_2290 95 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 153003364 Common - putative lipoprotein Anae109_0490 21 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 153003010 Nonpathogen - Methyltransferase type 11 Anae109_0133 2 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 153003930 Nonpathogen - hypothetical protein Anae109_1063 1 None None None 153003217 Common - acyl-ACP thioesterase Anae109_0343 28 COG3884 FatA, Acyl-ACP thioesterase Lipid metabolism 153003848 Nonpathogen - hypothetical protein Anae109_0980 2 None None None 153006028 Common - ABC transporter related Anae109_3173 249 COG3845 COG3845, ABC-type uncharacterized transport systems, ATPase components General function prediction only 153006124 Common - NAD(P)H dehydrogenase (quinone) Anae109_3275 74 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 153003722 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_0852 183 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153004298 Common - protein of unknown function DUF201 Anae109_1432 36 COG0439 AccC, Biotin carboxylase Lipid metabolism 153005395 Common - Holliday junction resolvase YqgF Anae109_2535 193 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 153005226 Common - multi-sensor signal transduction histidine kinase Anae109_2365 221 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 153003858 Common - major facilitator superfamily MFS_1 Anae109_0990 96 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153003037 Common - Methyltransferase type 11 Anae109_0160 80 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153003075 Nonpathogen - membrane protein involved in colicin uptake-like protein Anae109_0198 1 None None None 153003170 Common - translation elongation factor Ts Anae109_0294 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 153004975 Common - alpha-L-glutamate ligase, RimK family Anae109_2113 69 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 153006456 Common - Methyltransferase type 11 Anae109_3616 57 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 153004800 Common - DNA-directed RNA polymerase, alpha subunit Anae109_1938 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 153003348 Common - Trans-aconitate 2-methyltransferase Anae109_0474 45 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 153003176 Nonpathogen - hypothetical protein Anae109_0301 1 None None None 153005487 Nonpathogen - hypothetical protein Anae109_2627 1 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 153006362 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_3522 162 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153005201 Nonpathogen - hypothetical protein Anae109_2340 3 None None None 153007066 Common - AAA ATPase central domain protein Anae109_4229 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 153004636 Common - hypothetical protein Anae109_1774 51 COG5621 COG5621, Predicted secreted hydrolase General function prediction only 153005467 Common - glycosyl transferase group 1 Anae109_2607 212 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153006994 Common - L-seryl-tRNA(Sec) selenium transferase Anae109_4157 71 COG1921 SelA, Selenocysteine synthase [seryl-tRNASer selenium transferase] Amino acid transport and metabolism 153003690 Nonpathogen - hypothetical protein Anae109_0820 6 None None None 153005284 Common - DNA mismatch repair protein MutS domain protein Anae109_2424 94 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 153006576 Nonpathogen - hypothetical protein Anae109_3738 1 None None None 153005942 Nonpathogen - cytochrome c family protein Anae109_3087 3 None None None 153006643 Common - hypothetical protein Anae109_3805 32 COG3536 COG3536, Uncharacterized protein conserved in bacteria Function unknown 153006336 Common - CoA-binding domain protein Anae109_3494 85 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 153005438 Common - PfkB domain protein Anae109_2578 127 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 153002994 Common - cell shape determining protein, MreB/Mrl family Anae109_0117 223 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 153006741 Nonpathogen - hypothetical protein Anae109_3903 1 None None None 153005023 Common - Maltose O-acetyltransferase Anae109_2162 198 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 153003572 Common - HAD-superfamily hydrolase, subfamily IB (PSPase-like) Anae109_0700 13 COG4359 COG4359, Uncharacterized conserved protein Function unknown 153005568 Common - peptide chain release factor 2 Anae109_2708 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 153003395 Common - hydrogenase maturation protease Anae109_0522 47 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 153004196 Common - aspartyl-tRNA synthetase Anae109_1329 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153003898 Common - glucose sorbosone dehydrogenase Anae109_1030 118 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 153005539 Nonpathogen - hypothetical protein Anae109_2679 1 COG5466 COG5466, Predicted small metal-binding protein Function unknown 153004105 Common - glycosyl transferase family 2 Anae109_1238 53 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 153005804 Common - hypothetical protein Anae109_2946 28 COG3897 COG3897, Predicted methyltransferase General function prediction only 153007097 Nonpathogen - hypothetical protein Anae109_4260 1 None None None 153007310 Common - chaperone protein DnaJ Anae109_4473 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 153003416 Nonpathogen - hypothetical protein Anae109_0543 1 None None None 153005196 Nonpathogen - hypothetical protein Anae109_2335 1 None None None 153005528 Common - transcription elongation factor GreB Anae109_2668 187 COG0782 GreA, Transcription elongation factor Transcription 153005860 Nonpathogen - Abortive infection protein Anae109_3004 1 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 153005895 Common - HNH endonuclease Anae109_3039 4 COG1403 McrA, Restriction endonuclease Defense mechanisms 153007116 Nonpathogen - hypothetical protein Anae109_4279 1 None None None 153003402 Common - PAS/PAC sensor hybrid histidine kinase Anae109_0529 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153003836 Common - AMP-dependent synthetase and ligase Anae109_0968 215 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 153004470 Common - Hemerythrin HHE cation binding domain protein Anae109_1607 8 COG3945 COG3945, Uncharacterized conserved protein Function unknown 153005916 Common - hypothetical protein Anae109_3061 8 COG5522 COG5522, Predicted integral membrane protein Function unknown 153006896 Common - NAD-dependent epimerase/dehydratase Anae109_4059 50 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153004392 Common - putative lipoprotein Anae109_1527 3 None None None 153005544 Nonpathogen - heat shock protein DnaJ domain protein Anae109_2684 2 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 153002888 Common - protein of unknown function DUF224 cysteine-rich region domain protein Anae109_0009 96 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 153003205 Common - GTP cyclohydrolase I Anae109_0331 133 COG0780 COG0780, Enzyme related to GTP cyclohydrolase I General function prediction only 153006575 Common - endonuclease III Anae109_3737 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 153003731 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_0861 157 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153005696 Nonpathogen - hypothetical protein Anae109_2837 2 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 153003814 Common - protoheme IX farnesyltransferase Anae109_0946 160 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 153003701 Common - protein of unknown function DUF72 Anae109_0831 117 COG1801 COG1801, Uncharacterized conserved protein Function unknown 153006594 Nonpathogen - Tetratricopeptide TPR_4 Anae109_3756 2 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 153005624 Common - acyltransferase 3 Anae109_2765 26 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 153003543 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_0671 216 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153005548 Common - 20S proteasome A and B subunits Anae109_2688 149 COG5405 HslV, ATP-dependent protease HslVU (ClpYQ), peptidase subunit Posttranslational modification, protein turnover, chaperones 153006695 Common - putative PAS/PAC sensor protein Anae109_3857 95 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 153002891 Common - alpha-L-glutamate ligase, RimK family Anae109_0012 142 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 153005935 Common - heat shock protein Hsp20 Anae109_3080 146 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 153003118 Common - Rieske (2Fe-2S) domain protein Anae109_0241 42 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 153006756 Nonpathogen - hypothetical protein Anae109_3918 1 None None None 153002945 Common - Rhomboid family protein Anae109_0066 24 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 153005236 Nonpathogen - hypothetical protein Anae109_2375 1 None None None 153005138 Common - Inositol-3-phosphate synthase Anae109_2277 45 COG1260 INO1, Myo-inositol-1-phosphate synthase Lipid metabolism 153006247 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_3404 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153004424 Common - Rhodanese domain protein Anae109_1561 114 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 153007335 Common - ATP synthase F1, delta subunit Anae109_4498 186 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 153007034 Nonpathogen - hypothetical protein Anae109_4197 8 COG0392 COG0392, Predicted integral membrane protein Function unknown 153004999 Common - acyl-CoA dehydrogenase domain protein Anae109_2137 162 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 153005986 Common - glycoside hydrolase family 16 Anae109_3131 17 COG2273 SKN1, Beta-glucanase/Beta-glucan synthetase Carbohydrate transport and metabolism 153003622 Nonpathogen - hypothetical protein Anae109_0750 2 None None None 153005084 Common - ribosomal protein L10 Anae109_2223 214 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 153006161 Common - Transketolase domain protein Anae109_3317 227 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 153005034 Common - Homoserine dehydrogenase Anae109_2173 217 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 153004346 Common - putative transcriptional acitvator, Baf family Anae109_1480 128 COG1521 COG1521, Putative transcriptional regulator, homolog of Bvg accessory factor Transcription 153005629 Common - DNA topoisomerase (ATP-hydrolyzing) Anae109_2770 34 COG1697 COG1697, DNA topoisomerase VI, subunit A DNA replication, recombination, and repair 153006057 Nonpathogen - hypothetical protein Anae109_3202 1 None None None 153007130 Nonpathogen - hypothetical protein Anae109_4293 1 None None None 153004839 Common - ABC transporter related Anae109_1977 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 153005385 Common - Glycine dehydrogenase (decarboxylating) Anae109_2525 172 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 153006074 Common - glycosyl transferase group 1 Anae109_3220 97 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153003072 Common - Arginine N-succinyltransferase Anae109_0195 37 COG3138 AstA, Arginine/ornithine N-succinyltransferase beta subunit Amino acid transport and metabolism 153005872 Common - protein of unknown function DUF72 Anae109_3016 84 COG1801 COG1801, Uncharacterized conserved protein Function unknown 153006292 Common - Inositol-phosphate phosphatase Anae109_3449 190 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 153005787 Common - acetyltransferase-like protein Anae109_2928 41 COG2388 COG2388, Predicted acetyltransferase General function prediction only 153003770 Common - transcriptional regulator, BadM/Rrf2 family Anae109_0902 155 COG1959 COG1959, Predicted transcriptional regulator Transcription 153004946 Nonpathogen - hypothetical protein Anae109_2084 2 None None None 153003435 Common - cupin 2, conserved barrel Anae109_0562 13 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 153007200 Common - hypothetical protein Anae109_4363 5 None None None 153003527 Nonpathogen - CheW domain protein Anae109_0655 1 None None None 153003446 Common - Polyphosphate kinase Anae109_0573 161 COG0855 Ppk, Polyphosphate kinase Inorganic ion transport and metabolism 153005145 Common - FAD dependent oxidoreductase Anae109_2284 62 COG2509 COG2509, Uncharacterized FAD-dependent dehydrogenases General function prediction only 153007059 Nonpathogen - hypothetical protein Anae109_4222 1 None None None 153006498 Common - hypothetical protein Anae109_3659 70 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 153006716 Common - Peptidoglycan glycosyltransferase Anae109_3878 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 153004736 Common - 2-isopropylmalate synthase Anae109_1874 214 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 153005581 Nonpathogen - hypothetical protein Anae109_2721 1 None None None 153004264 Nonpathogen - sigma-70 region 4 domain protein Anae109_1398 3 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 153005963 Common - multicopper oxidase type 2 Anae109_3108 17 None None None 153002988 Common - integral membrane sensor signal transduction histidine kinase Anae109_0111 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153004721 Nonpathogen - hypothetical protein Anae109_1859 2 None None None 153006455 Common - hypothetical protein Anae109_3615 18 COG4588 AcfC, Accessory colonization factor AcfC, contains ABC-type periplasmic domain General function prediction only 153003299 Common - phosphoesterase PA-phosphatase related Anae109_0425 5 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 153004141 Nonpathogen - Colicin V production protein Anae109_1274 1 COG1286 CvpA, Uncharacterized membrane protein, required for colicin V production General function prediction only 153003999 Common - exodeoxyribonuclease VII, large subunit Anae109_1132 205 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 153005758 Nonpathogen - acyl-CoA dehydrogenase domain protein Anae109_2899 3 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 153006347 Common - hypothetical protein Anae109_3505 19 COG4850 COG4850, Uncharacterized conserved protein Function unknown 153004339 Common - protein of unknown function DUF305 Anae109_1473 27 COG3544 COG3544, Uncharacterized protein conserved in bacteria Function unknown 153006046 Common - sigma54 specific transcriptional regulator, Fis family Anae109_3191 174 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 153004535 Common - phosphoesterase PA-phosphatase related Anae109_1672 64 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 153003038 Common - adenosylhomocysteinase Anae109_0161 177 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 153004499 Common - short-chain dehydrogenase/reductase SDR Anae109_1636 225 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 153004167 Common - HNH endonuclease Anae109_1300 4 COG1403 McrA, Restriction endonuclease Defense mechanisms 153004412 Nonpathogen - hypothetical protein Anae109_1548 1 None None None 153006403 Nonpathogen - hypothetical protein Anae109_3563 8 None None None 153006867 Common - putative CBS domain and cyclic nucleotide-regulated nucleotidyltransferase Anae109_4030 80 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 153006097 Common - hypothetical protein Anae109_3245 2 None None None 153003945 Nonpathogen - hypothetical protein Anae109_1078 1 None None None 153005741 Nonpathogen - hypothetical protein Anae109_2882 1 None None None 153003512 Common - co-chaperone Hsc20 Anae109_0640 52 COG1076 DjlA, DnaJ-domain-containing proteins 1 Posttranslational modification, protein turnover, chaperones 153003677 Common - cyclase/dehydrase Anae109_0807 33 COG4276 COG4276, Uncharacterized conserved protein Function unknown 153004908 Common - protease Do Anae109_2046 223 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 153006080 Common - ABC transporter related Anae109_3226 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 153004303 Common - protein of unknown function DUF224 cysteine-rich region domain protein Anae109_1437 162 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 153003292 Common - phosphate binding protein Anae109_0418 143 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 153003679 Nonpathogen - diacylglycerol kinase Anae109_0809 1 COG0818 DgkA, Diacylglycerol kinase Cell envelope biogenesis, outer membrane 153003436 Common - beta-lactamase domain protein Anae109_0563 26 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 153003985 Common - protein of unknown function DUF214 Anae109_1118 215 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 153003169 Nonpathogen - hypothetical protein Anae109_0293 2 None None None 153005662 Common - glutathione-dependent formaldehyde-activating GFA Anae109_2803 37 COG3791 COG3791, Uncharacterized conserved protein Function unknown 153003716 Nonpathogen - hypothetical protein Anae109_0846 1 None None None 153004822 Nonpathogen - hypothetical protein Anae109_1960 5 None None None 153002901 Common - hypothetical protein Anae109_0022 8 COG5381 COG5381, Uncharacterized protein conserved in bacteria Function unknown 153004972 Common - ThiJ/PfpI domain protein Anae109_2110 38 COG3155 ElbB, Uncharacterized protein involved in an early stage of isoprenoid biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 153004104 Common - hypothetical protein Anae109_1237 11 None None None 153006472 Common - histidine kinase Anae109_3632 216 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153006933 Nonpathogen - outer membrane efflux protein Anae109_4096 3 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 153005866 Nonpathogen - protein of unknown function DUF1206 Anae109_3010 1 None None None 153006428 Common - short-chain dehydrogenase/reductase SDR Anae109_3588 232 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153003231 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Anae109_0357 171 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 153004111 Common - DegT/DnrJ/EryC1/StrS aminotransferase Anae109_1244 201 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 153006139 Nonpathogen - hypothetical protein Anae109_3291 1 None None None 153006008 Common - hypothetical protein Anae109_3153 68 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 153007014 Common - GCN5-related N-acetyltransferase Anae109_4177 15 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 153007255 Nonpathogen - hypothetical protein Anae109_4418 2 COG1647 COG1647, Esterase/lipase General function prediction only 153005858 Common - acyl-CoA dehydrogenase domain protein Anae109_3002 138 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 153006265 Common - trigger factor Anae109_3422 212 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 153006432 Common - Tetratricopeptide TPR_2 repeat protein Anae109_3592 38 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 153006956 Common - hemerythrin-like metal-binding protein Anae109_4119 47 COG2703 COG2703, Hemerythrin Inorganic ion transport and metabolism 153003087 Common - glycosyl transferase family 2 Anae109_0210 87 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 153004533 Nonpathogen - outer membrane lipoprotein, putative Anae109_1670 1 COG3133 SlyB, Outer membrane lipoprotein Cell envelope biogenesis, outer membrane 153002958 Common - Water Stress and Hypersensitive response domain protein Anae109_0079 9 COG5608 COG5608, Conserved secreted protein Function unknown 153004237 Common - rod shape-determining protein RodA Anae109_1371 206 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 153003605 Common - ribosomal protein L31 Anae109_0733 169 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 153004086 Common - cytochrome c oxidase, cbb3-type, subunit II Anae109_1219 82 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 153005672 Common - translation elongation factor G Anae109_2813 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 153004605 Common - ribonuclease H Anae109_1743 172 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 153004932 Nonpathogen - hypothetical protein Anae109_2070 2 None None None 153006971 Nonpathogen - hypothetical protein Anae109_4134 1 None None None 153006963 Nonpathogen - peptidase S41 Anae109_4126 1 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 153003601 Common - general secretory pathway protein E Anae109_0729 218 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 153005764 Nonpathogen - Putative protein-S-isoprenylcysteine methyltransferase-like protein Anae109_2905 1 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 153006302 Common - beta-lactamase Anae109_3459 67 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 153006929 Common - biotin/lipoyl attachment domain-containing protein Anae109_4092 220 COG0439 AccC, Biotin carboxylase Lipid metabolism 153007004 Common - SAM-dependent methyltransferase Anae109_4167 8 None None None 153004443 Common - alpha/beta hydrolase fold Anae109_1580 168 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153003423 Common - aldo/keto reductase Anae109_0550 182 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 153003688 Nonpathogen - hypothetical protein Anae109_0818 1 None None None 153003040 Common - putative undecaprenol kinase Anae109_0163 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 153005888 Common - transcriptional regulator, NifA subfamily, Fis Family Anae109_3032 163 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 153006212 Nonpathogen - hypothetical protein Anae109_3369 1 None None None 153004340 Common - response regulator receiver modulated diguanylate cyclase Anae109_1474 224 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153005074 Common - 1-acyl-sn-glycerol-3-phosphate acyltransferase Anae109_2213 208 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 153003135 Common - phosphoribosyltransferase Anae109_0258 99 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 153005450 Nonpathogen - hypothetical protein Anae109_2590 1 None None None 153003950 Common - hypothetical protein Anae109_1083 5 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 153004354 Nonpathogen - putative transmembrane anti-sigma factor Anae109_1488 2 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 153004325 Nonpathogen - hypothetical protein Anae109_1459 1 None None None 153005688 Nonpathogen - hypothetical protein Anae109_2829 3 None None None 153006836 Common - TIR protein Anae109_3999 15 None None None 153004952 Nonpathogen - hypothetical protein Anae109_2090 1 None None None 153004541 Common - ABC transporter related Anae109_1678 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 153006371 Nonpathogen - hypothetical protein Anae109_3531 1 None None None 153004408 Common - plasmid pRiA4b ORF-3 family protein Anae109_1544 80 COG3791 COG3791, Uncharacterized conserved protein Function unknown 153006442 Nonpathogen - hypothetical protein Anae109_3602 1 None None None 153004173 Common - Conserved hypothetical protein CHP02757 Anae109_1306 22 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 153007023 Common - histidine kinase Anae109_4186 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153006411 Common - helix-hairpin-helix motif Anae109_3571 33 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 153003867 Nonpathogen - hypothetical protein Anae109_0999 1 None None None 153004529 Common - NADPH-dependent FMN reductase Anae109_1666 119 COG0431 COG0431, Predicted flavoprotein General function prediction only 153006418 Common - transcriptional regulator, TraR/DksA family Anae109_3578 60 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 153007336 Common - heat shock protein Hsp20 Anae109_4499 160 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 153004888 Common - sugar-phosphate isomerase, RpiB/LacA/LacB family Anae109_2026 128 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 153006440 Common - CrcB protein Anae109_3600 168 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 153004490 Nonpathogen - hypothetical protein Anae109_1627 1 COG3213 NnrS, Uncharacterized protein involved in response to NO Inorganic ion transport and metabolism 153006155 Nonpathogen - hypothetical protein Anae109_3311 1 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 153006275 Nonpathogen - hypothetical protein Anae109_3432 1 None None None 153004047 Common - CutA1 divalent ion tolerance protein Anae109_1180 116 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 153004252 Nonpathogen - LigA Anae109_1386 1 COG3846 TrbL, Type IV secretory pathway, TrbL components Intracellular trafficking and secretion 153004886 Nonpathogen - hypothetical protein Anae109_2024 1 None None None 153006553 Common - chaperonin GroEL Anae109_3715 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 153005499 Common - aminotransferase class IV Anae109_2639 189 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 153005573 Common - PhoH family protein Anae109_2713 199 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 153005417 Common - pyruvate phosphate dikinase PEP/pyruvate-binding Anae109_2557 122 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 153002971 Common - glycosyl transferase family 2 Anae109_0092 3 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 153005774 Common - putative lipoprotein Anae109_2915 57 None None None 153005682 Common - histidine kinase Anae109_2823 217 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153003467 Common - protein of unknown function DUF6 transmembrane Anae109_0594 22 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 153006086 Common - hypothetical protein Anae109_3233 29 COG5496 COG5496, Predicted thioesterase General function prediction only 153005350 Common - cytochrome c class I Anae109_2490 35 COG3258 COG3258, Cytochrome c Energy production and conversion 153003499 Nonpathogen - hypothetical protein Anae109_0627 1 None None None 153003189 Nonpathogen - regulatory protein LuxR Anae109_0314 1 COG2771 CsgD, DNA-binding HTH domain-containing proteins Transcription 153003656 Common - protein of unknown function UPF0118 Anae109_0785 64 COG0628 PerM, Predicted permease General function prediction only 153004922 Common - WD40 domain protein beta Propeller Anae109_2060 136 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 153006115 Common - hypothetical protein Anae109_3263 7 None None None 153003579 Nonpathogen - LigA Anae109_0707 1 None None None 153003864 Nonpathogen - hypothetical protein Anae109_0996 1 None None None 153006315 Nonpathogen - hypothetical protein Anae109_3472 1 None None None 153006774 Common - DNA repair protein RadC Anae109_3937 79 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 153006307 Common - Glutathione S-transferase domain Anae109_3464 37 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 153006731 Common - cell division protein FtsA Anae109_3893 208 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 153006761 Nonpathogen - putative vgr-related protein Anae109_3923 1 COG2263 COG2263, Predicted RNA methylase Translation, ribosomal structure and biogenesis 153005331 Common - Dihydroorotate oxidase Anae109_2471 235 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 153005852 Nonpathogen - methyl-CpG binding protein MBD2-like protein Anae109_2996 1 None None None 153004124 Common - hypothetical protein Anae109_1257 8 None None None 153004018 Common - Phosphoribosylaminoimidazolesuccinocarboxamide synthase Anae109_1151 205 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 153002911 Common - short-chain dehydrogenase/reductase SDR Anae109_0032 236 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 153004873 Common - formate dehydrogenase accessory protein FdhE Anae109_2011 35 COG3058 FdhE, Uncharacterized protein involved in formate dehydrogenase formation Posttranslational modification, protein turnover, chaperones 153004774 Common - ribosomal protein L4/L1e Anae109_1912 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 153006065 Nonpathogen - hypothetical protein Anae109_3211 13 COG4641 COG4641, Uncharacterized protein conserved in bacteria Function unknown 153006191 Common - Zn-dependent alcohol dehydrogenase Anae109_3348 20 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 153006035 Nonpathogen - hypothetical protein Anae109_3180 1 COG1873 COG1873, Uncharacterized conserved protein Function unknown 153004947 Common - Stearoyl-CoA 9-desaturase Anae109_2085 61 COG1398 OLE1, Fatty-acid desaturase Lipid metabolism 153003156 Common - acetyl-CoA carboxylase, biotin carboxylase Anae109_0279 225 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 153004518 Common - cytochrome bd ubiquinol oxidase subunit I Anae109_1655 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 153005612 Common - aromatic amino acid hydroxylase Anae109_2753 45 COG3186 COG3186, Phenylalanine-4-hydroxylase Amino acid transport and metabolism 153006541 Common - putative membrane-associated zinc metalloprotease Anae109_3703 211 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 153003992 Common - protein of unknown function DUF1009 Anae109_1125 45 COG3494 COG3494, Uncharacterized protein conserved in bacteria Function unknown 153006560 Common - hypothetical protein Anae109_3722 16 None None None 153004900 Nonpathogen - large conductance mechanosensitive channel protein Anae109_2038 1 COG1970 MscL, Large-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 153003963 Common - 5-formyltetrahydrofolate cyclo-ligase Anae109_1096 154 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 153006798 Nonpathogen - hypothetical protein Anae109_3961 2 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 153006887 Common - Os02g0168000 Anae109_4050 12 COG0830 UreF, Urease accessory protein UreF Posttranslational modification, protein turnover, chaperones 153007073 Common - hypothetical protein Anae109_4236 14 None None None 153004378 Nonpathogen - hypothetical protein Anae109_1512 1 None None None 153004678 Nonpathogen - hypothetical protein Anae109_1816 2 None None None 153004588 Common - DNA-(apurinic or apyrimidinic site) lyase Anae109_1725 68 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 153004232 Common - maf protein Anae109_1366 197 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 153003056 Common - Glutamate carboxypeptidase Anae109_0179 73 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 153005232 Nonpathogen - putative CheW protein Anae109_2371 2 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153006829 Common - helicase domain protein Anae109_3992 12 None None None 153002895 Nonpathogen - hypothetical protein Anae109_0016 6 None None None 153007199 Common - phosphoribosylformylglycinamidine synthase II Anae109_4362 234 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 153003262 Common - Redoxin domain protein Anae109_0388 130 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 153003903 Nonpathogen - hypothetical protein Anae109_1035 2 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153005219 Common - Methyltransferase type 11 Anae109_2358 138 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153005326 Nonpathogen - hypothetical protein Anae109_2466 2 None None None 153003021 Nonpathogen - transcriptional regulator, TetR family Anae109_0144 7 COG1309 AcrR, Transcriptional regulator Transcription 153007103 Common - copper resistance B precursor Anae109_4266 43 COG3667 PcoB, Uncharacterized protein involved in copper resistance Inorganic ion transport and metabolism 153003713 Common - conserved hypothetical protein-transmembrane prediction Anae109_0843 21 None None None 153004740 Common - acetolactate synthase, small subunit Anae109_1878 191 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 153005062 Common - hypothetical protein Anae109_2201 56 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 153005717 Nonpathogen - hypothetical protein Anae109_2858 1 None None None 153004002 Common - Polyprenyl synthetase Anae109_1135 226 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 153004248 Nonpathogen - hypothetical protein Anae109_1382 2 None None None 153004595 Common - potassium efflux system protein Anae109_1733 127 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 153005335 Nonpathogen - hypothetical protein Anae109_2475 3 None None None 153004439 Nonpathogen - hypothetical protein Anae109_1576 2 None None None 153004937 Common - protein-L-isoaspartate O-methyltransferase Anae109_2075 156 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 153005210 Common - D-Lysine 56-aminomutase alpha subunit Anae109_2349 17 None None None 153006078 Common - hypothetical protein Anae109_3224 12 COG3846 TrbL, Type IV secretory pathway, TrbL components Intracellular trafficking and secretion 153005827 Nonpathogen - hypothetical protein Anae109_2969 1 None None None 153003868 Common - Rhomboid family protein Anae109_1000 134 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 153004157 Common - NADH-ubiquinone/plastoquinone oxidoreductase chain 3 Anae109_1290 163 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 153006013 Common - ATPase, P-type (transporting), HAD superfamily, subfamily IC Anae109_3158 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 153004584 Nonpathogen - hypothetical protein Anae109_1721 1 None None None 153005370 Common - FolC bifunctional protein Anae109_2510 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 153007110 Common - Sel1 domain protein repeat-containing protein Anae109_4273 6 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 153004846 Common - hypothetical protein Anae109_1984 14 COG0392 COG0392, Predicted integral membrane protein Function unknown 153005150 Common - Tetratricopeptide TPR_2 repeat protein Anae109_2289 55 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 153007278 Common - GDP-mannose 4,6-dehydratase Anae109_4441 214 COG1089 Gmd, GDP-D-mannose dehydratase Cell envelope biogenesis, outer membrane 153002910 Common - drug resistance transporter, EmrB/QacA subfamily Anae109_0031 211 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 153004640 Common - glycosyl transferase family 2 Anae109_1778 113 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 153006902 Common - NmrA family protein Anae109_4065 56 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153004042 Common - inner-membrane translocator Anae109_1175 134 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 153005069 Common - SCP-like extracellular Anae109_2208 24 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 153004004 Common - hemolysin A Anae109_1137 132 COG1189 COG1189, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 153005706 Common - WD40 domain protein beta Propeller Anae109_2847 121 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 153007136 Common - signal peptidase I Anae109_4299 204 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 153004657 Common - formyltetrahydrofolate deformylase Anae109_1795 217 COG0788 PurU, Formyltetrahydrofolate hydrolase Nucleotide transport and metabolism 153006480 Nonpathogen - hypothetical protein Anae109_3641 9 None None None 153006297 Common - histone deacetylase superfamily Anae109_3454 91 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 153006383 Nonpathogen - transcriptional regulator, TetR family Anae109_3543 2 COG1309 AcrR, Transcriptional regulator Transcription 153003490 Common - hemerythrin-like metal-binding protein Anae109_0618 34 COG2703 COG2703, Hemerythrin Inorganic ion transport and metabolism 153005390 Nonpathogen - hypothetical protein Anae109_2530 2 COG4299 COG4299, Uncharacterized protein conserved in bacteria Function unknown 153003617 Common - Yop virulence translocation R Anae109_0745 126 COG4790 EscR, Type III secretory pathway, component EscR Intracellular trafficking and secretion 153005855 Common - FAD linked oxidase domain protein Anae109_2999 194 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 153004451 Common - isocitrate dehydrogenase, NADP-dependent Anae109_1588 65 COG2838 Icd, Monomeric isocitrate dehydrogenase Energy production and conversion 153005596 Common - acyl carrier protein Anae109_2736 186 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153004865 Nonpathogen - hypothetical protein Anae109_2003 1 None None None 153003301 Common - aliphatic sulfonates family ABC transporter, periplsmic ligand-binding protein Anae109_0427 52 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 153006903 Nonpathogen - hypothetical protein Anae109_4066 1 None None None 153006693 Common - alpha/beta hydrolase fold Anae109_3855 147 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153003391 Common - (NiFe) hydrogenase maturation protein HypF Anae109_0518 109 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 153005670 Nonpathogen - hypothetical protein Anae109_2811 2 None None None 153005975 Nonpathogen - hypothetical protein Anae109_3120 1 None None None 153006272 Nonpathogen - hypothetical protein Anae109_3429 1 None None None 153006789 Common - CBS domain containing protein Anae109_3952 219 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 153005193 Nonpathogen - holo-acyl-carrier-protein synthase Anae109_2332 1 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 153003064 Common - protein of unknown function DUF214 Anae109_0187 102 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 153004684 Common - glycosyl transferase family 2 Anae109_1822 182 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 153005843 Common - Alcohol dehydrogenase zinc-binding domain protein Anae109_2985 177 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 153007046 Common - 4-hydroxybenzoate polyprenyltransferase, putative Anae109_4209 92 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 153006243 Nonpathogen - HNH endonuclease Anae109_3400 3 COG1403 McrA, Restriction endonuclease Defense mechanisms 153003035 Common - phosphoenolpyruvate-protein phosphotransferase Anae109_0158 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 153004992 Common - protein of unknown function DUF59 Anae109_2130 232 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 153004281 Common - Porphobilinogen synthase Anae109_1415 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 153003353 Nonpathogen - hypothetical protein Anae109_0479 3 None None None 153004226 Nonpathogen - hypothetical protein Anae109_1360 4 COG2952 COG2952, Uncharacterized protein conserved in bacteria Function unknown 153007325 Nonpathogen - hypothetical protein Anae109_4488 1 None None None 153004450 Common - isocitrate lyase Anae109_1587 123 COG2224 AceA, Isocitrate lyase Energy production and conversion 153006433 Common - molybdopterin-guanine dinucleotide biosynthesis protein A Anae109_3593 122 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 153005970 Common - Tetratricopeptide TPR_2 repeat protein Anae109_3115 71 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 153003911 Common - ABC transporter related Anae109_1043 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 153005076 Common - response regulator receiver protein Anae109_2215 7 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153005277 Common - Peptidase M1 membrane alanine aminopeptidase Anae109_2417 161 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 153007081 Common - amino acid permease-associated region Anae109_4244 54 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 153006093 Nonpathogen - hypothetical protein Anae109_3240 3 None None None 153004277 Common - glycosyl transferase family 2 Anae109_1411 103 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 153003126 Nonpathogen - hypothetical protein Anae109_0249 1 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 153007220 Common - pyruvate kinase Anae109_4383 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 153004717 Common - histidine kinase Anae109_1855 223 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153004179 Common - putative endoribonuclease L-PSP Anae109_1312 196 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 153005794 Nonpathogen - hypothetical protein Anae109_2935 1 None None None 153005186 Common - YD repeat protein Anae109_2325 85 COG1572 COG1572, Uncharacterized conserved protein Function unknown 153005633 Common - Alcohol dehydrogenase zinc-binding domain protein Anae109_2774 197 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 153006279 Common - ribosomal protein S9 Anae109_3436 248 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 153006819 Nonpathogen - hypothetical protein Anae109_3982 1 None None None 153005656 Common - phage integrase family protein Anae109_2797 212 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 153004516 Common - putative alkylated DNA repair protein Anae109_1653 23 COG3145 AlkB, Alkylated DNA repair protein DNA replication, recombination, and repair 153004600 Common - Ig domain protein group 2 domain protein Anae109_1738 20 COG5492 COG5492, Bacterial surface proteins containing Ig-like domains Cell motility and secretion 153003798 Common - response regulator receiver protein Anae109_0930 205 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153004333 Common - Patatin Anae109_1467 123 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 153003807 Common - DNA ligase D Anae109_0939 110 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 153003585 Common - carboxyl-terminal protease Anae109_0713 183 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 153003254 Common - DSBA oxidoreductase Anae109_0380 111 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 153006611 Nonpathogen - parallel beta-helix repeat protein Anae109_3773 1 None None None 153003457 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_0584 10 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153003886 Nonpathogen - hypothetical protein Anae109_1018 1 None None None 153003924 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Anae109_1057 16 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 153005861 Common - GAF sensor signal transduction histidine kinase Anae109_3005 222 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 153006144 Nonpathogen - hypothetical protein Anae109_3296 3 None None None 153006166 Common - heat shock protein Hsp20 Anae109_3323 151 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 153003705 Common - ATP-dependent Clp protease, ATP-binding subunit clpA Anae109_0835 228 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 153003774 Common - cysteine desulfurase, SufS subfamily Anae109_0906 237 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 153005710 Nonpathogen - hypothetical protein Anae109_2851 1 COG4244 COG4244, Predicted membrane protein Function unknown 153006890 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Anae109_4053 56 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 153006463 Common - pyridine nucleotide-disulphide oxidoreductase dimerisation region Anae109_3623 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 153004917 Common - helix-turn-helix- domain containing protein AraC type Anae109_2055 109 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 153005421 Nonpathogen - hypothetical protein Anae109_2561 1 COG5502 COG5502, Uncharacterized conserved protein Function unknown 153007285 Common - glycosyl transferase family 2 Anae109_4448 165 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 153007264 Nonpathogen - hypothetical protein Anae109_4427 1 None None None 153006581 Common - CDP-diacylglycerol--serine O-phosphatidyltransferase Anae109_3743 139 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 153005524 Nonpathogen - hypothetical protein Anae109_2664 1 None None None 153006459 Nonpathogen - hypothetical protein Anae109_3619 1 None None None 153006225 Nonpathogen - hypothetical protein Anae109_3382 2 None None None 153007156 Common - 3-deoxy-D-manno-octulosonate cytidylyltransferase Anae109_4319 137 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 153004035 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Anae109_1168 9 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 153004612 Nonpathogen - Rubrerythrin Anae109_1750 3 COG1633 COG1633, Uncharacterized conserved protein Function unknown 153005939 Nonpathogen - hypothetical protein Anae109_3084 2 None None None 153005922 Nonpathogen - putative lipoprotein Anae109_3067 22 COG4880 COG4880, Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats General function prediction only 153003107 Common - protein of unknown function DUF6 transmembrane Anae109_0230 60 None None None 153003940 Nonpathogen - hypothetical protein Anae109_1073 2 None None None 153006647 Common - 3-methyl-2-oxobutanoate hydroxymethyltransferase Anae109_3809 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 153003730 Common - Polysulphide reductase NrfD Anae109_0860 7 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 153005265 Nonpathogen - cytochrome c class I Anae109_2405 4 COG2863 COG2863, Cytochrome c553 Energy production and conversion 153005270 Nonpathogen - HNH endonuclease Anae109_2410 1 None None None 153006489 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Anae109_3650 48 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 153003502 Common - ATPase AAA-2 domain protein Anae109_0630 215 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 153005405 Common - RNA polymerase sigma-70 Anae109_2545 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 153005936 Common - hypothetical protein Anae109_3081 9 None None None 153005945 Nonpathogen - hypothetical protein Anae109_3090 3 None None None 153003698 Common - methyltransferase small Anae109_0828 27 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 153003274 Nonpathogen - hypothetical protein Anae109_0400 1 None None None 153004294 Common - Aromatic-L-amino-acid decarboxylase Anae109_1428 84 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 153007122 Common - response regulator receiver protein Anae109_4285 209 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153003791 Nonpathogen - hypothetical protein Anae109_0923 1 None None None 153003626 Common - Imidazoleglycerol-phosphate dehydratase Anae109_0754 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 153003967 Common - apurinic endonuclease Apn1 Anae109_1100 97 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 153007231 Nonpathogen - hypothetical protein Anae109_4394 2 COG4929 COG4929, Uncharacterized membrane-anchored protein Function unknown 153004776 Common - ribosomal protein L2 Anae109_1914 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 153004796 Nonpathogen - ribosomal protein L36 Anae109_1934 1 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 153004289 Common - hypothetical protein Anae109_1423 8 COG2342 COG2342, Predicted extracellular endo alpha-1,4 polygalactosaminidase or related polysaccharide hydrolase Carbohydrate transport and metabolism 153004811 Common - GCN5-related N-acetyltransferase Anae109_1949 27 COG2808 PaiB, Transcriptional regulator Transcription 153002946 Nonpathogen - hypothetical protein Anae109_0067 2 COG5373 COG5373, Predicted membrane protein Function unknown 153004983 Common - putative transcriptional regulator Anae109_2121 157 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 153004527 Common - binding-protein-dependent transport systems inner membrane component Anae109_1664 145 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 153005117 Nonpathogen - glutaredoxin Anae109_2256 2 None None None 153005146 Nonpathogen - hypothetical protein Anae109_2285 1 None None None 153004784 Common - ribosomal protein L24 Anae109_1922 200 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 153003519 Common - CheA signal transduction histidine kinase Anae109_0647 154 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 153004671 Common - histidine kinase Anae109_1809 160 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 153004902 Nonpathogen - homocysteine S-methyltransferase Anae109_2040 14 COG0646 MetH, Methionine synthase I (cobalamin-dependent), methyltransferase domain Amino acid transport and metabolism 153005803 Common - type IV pilus assembly PilZ Anae109_2945 19 None None None 153007008 Common - protein of unknown function DUF990 Anae109_4171 27 COG3694 COG3694, ABC-type uncharacterized transport system, permease component General function prediction only 153003749 Common - integral membrane sensor signal transduction histidine kinase Anae109_0881 214 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153003815 Common - putative lipoprotein Anae109_0947 19 None None None 153005319 Common - glycyl-tRNA synthetase, beta subunit Anae109_2459 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 153006217 Common - hypothetical protein Anae109_3374 12 COG1285 SapB, Uncharacterized membrane protein Function unknown 153004381 Common - HNH endonuclease Anae109_1516 5 COG1403 McrA, Restriction endonuclease Defense mechanisms 153006634 Nonpathogen - hypothetical protein Anae109_3796 1 None None None 153007182 Nonpathogen - hypothetical protein Anae109_4345 1 COG2881 COG2881, Uncharacterized protein conserved in archaea Function unknown 153004554 Common - efflux transporter, RND family, MFP subunit Anae109_1691 62 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153006996 Common - two component transcriptional regulator, winged helix family Anae109_4159 226 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153003792 Common - LemA family protein Anae109_0924 130 COG1704 LemA, Uncharacterized conserved protein Function unknown 153003165 Common - Biopolymer transport protein ExbD/TolR Anae109_0289 21 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 153004463 Common - helix-turn-helix- domain containing protein AraC type Anae109_1600 111 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 153005161 Nonpathogen - hypothetical protein Anae109_2300 1 None None None 153004578 Common - transport-associated Anae109_1715 13 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 153004180 Nonpathogen - hypothetical protein Anae109_1313 1 None None None 153006555 Nonpathogen - hypothetical protein Anae109_3717 5 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153003939 Nonpathogen - hypothetical protein Anae109_1072 3 None None None 153004751 Common - short-chain dehydrogenase/reductase SDR Anae109_1889 236 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 153005691 Common - putative RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_2832 42 COG4941 COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain Transcription 153004193 Nonpathogen - hypothetical protein Anae109_1326 5 None None None 153007295 Common - protein of unknown function DUF111 Anae109_4458 64 COG1641 COG1641, Uncharacterized conserved protein Function unknown 153002952 Common - 2-alkenal reductase Anae109_0073 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 153003783 Common - two component transcriptional regulator, LuxR family Anae109_0915 155 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 153004069 Common - haloacid dehalogenase, type II Anae109_1202 63 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 153007176 Common - glutamyl-tRNA(Gln) amidotransferase, C subunit Anae109_4339 33 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 153003312 Common - TRAP dicarboxylate transporter, DctM subunit Anae109_0438 117 COG1593 DctQ, TRAP-type C4-dicarboxylate transport system, large permease component Carbohydrate transport and metabolism 153003973 Common - glycogen debranching enzyme GlgX Anae109_1106 153 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 153006934 Common - peptidase M56 BlaR1 Anae109_4097 4 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 153007219 Nonpathogen - hypothetical protein Anae109_4382 1 None None None 153004219 Nonpathogen - Rhodanese domain protein Anae109_1353 2 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 153003463 Common - NAD-dependent epimerase/dehydratase Anae109_0590 74 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153003268 Common - MotA/TolQ/ExbB proton channel Anae109_0394 132 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 153004093 Common - cytochrome oxidase maturation protein, cbb3-type Anae109_1226 7 COG3197 FixS, Uncharacterized protein, possibly involved in nitrogen fixation Inorganic ion transport and metabolism 153004016 Nonpathogen - hypothetical protein Anae109_1149 1 None None None 153004851 Common - cobalamin B12-binding domain protein Anae109_1989 113 COG2185 Sbm, Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) Lipid metabolism 153005008 Common - alkylhydroperoxidase like protein, AhpD family Anae109_2147 25 None None None 153006037 Common - Radical SAM domain protein Anae109_3182 75 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 153003065 Nonpathogen - hypothetical protein Anae109_0188 1 None None None 153006450 Common - hypothetical protein Anae109_3610 12 COG1310 COG1310, Predicted metal-dependent protease of the PAD1/JAB1 superfamily General function prediction only 153005208 Common - cobalamin vitamin B12-binding protein Anae109_2347 19 COG5012 COG5012, Predicted cobalamin binding protein General function prediction only 153006711 Common - short-chain dehydrogenase/reductase SDR Anae109_3873 136 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153006782 Common - pyridine nucleotide-disulphide oxidoreductase dimerisation region Anae109_3945 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 153003666 Nonpathogen - hypothetical protein Anae109_0796 1 None None None 153005092 Nonpathogen - hypothetical protein Anae109_2231 2 None None None 153005925 Common - 1,4-alpha-glucan branching enzyme Anae109_3070 154 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 153004430 Nonpathogen - hypothetical protein Anae109_1567 2 None None None 153006504 Nonpathogen - hypothetical protein Anae109_3665 1 None None None 153004207 Nonpathogen - hypothetical protein Anae109_1340 1 None None None 153003211 Nonpathogen - hypothetical protein Anae109_0337 1 None None None 153004200 Nonpathogen - hypothetical protein Anae109_1333 1 None None None 153007183 Common - NADH-ubiquinone oxidoreductase chain 4L Anae109_4346 11 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 153003428 Nonpathogen - hypothetical protein Anae109_0555 2 None None None 153006207 Common - protein of unknown function DUF815 Anae109_3364 89 COG2607 COG2607, Predicted ATPase (AAA+ superfamily) General function prediction only 153003044 Common - ROK family protein Anae109_0167 150 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 153006352 Common - hypothetical protein Anae109_3510 14 None None None 153003122 Common - hypothetical protein Anae109_0245 12 None None None 153003531 Common - Protein-glutamate O-methyltransferase Anae109_0659 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 153006087 Common - Radical SAM domain protein Anae109_3234 81 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 153006674 Common - SSS sodium solute transporter superfamily Anae109_3836 181 COG4147 DhlC, Predicted symporter General function prediction only 153005727 Common - AsmA family protein Anae109_2868 4 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 153005368 Common - organic solvent tolerance protein OstA-like protein Anae109_2508 16 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 153003949 Nonpathogen - hypothetical protein Anae109_1082 1 None None None 153004064 Nonpathogen - hypothetical protein Anae109_1197 1 None None None 153006850 Nonpathogen - hypothetical protein Anae109_4013 1 None None None 153005957 Nonpathogen - hypothetical protein Anae109_3102 1 None None None 153006965 Common - 2-oxo-acid dehydrogenase E1 subunit, homodimeric type Anae109_4128 151 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 153004969 Common - DNA mismatch repair protein MutS Anae109_2107 201 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 153006603 Nonpathogen - hypothetical protein Anae109_3765 1 None None None 153004475 Common - protein of unknown function DUF28 Anae109_1612 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 153006510 Nonpathogen - hypothetical protein Anae109_3671 1 None None None 153006951 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Anae109_4114 116 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 153007212 Common - histidine kinase Anae109_4375 52 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153003878 Common - acetyl-CoA hydrolase/transferase Anae109_1010 98 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 153003240 Common - PGAP1 family protein Anae109_0366 38 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 153003584 Common - peptidase M23B Anae109_0712 182 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 153006179 Common - heat shock protein Hsp20 Anae109_3336 157 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 153003525 Common - response regulator receiver protein Anae109_0653 220 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 153005414 Common - hypothetical protein Anae109_2554 40 COG2912 COG2912, Uncharacterized conserved protein Function unknown 153003471 Common - Phosphoglycerate mutase Anae109_0598 101 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 153006563 Common - sigma54 specific transcriptional regulator, Fis family Anae109_3725 171 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 153007244 Nonpathogen - hypothetical protein Anae109_4407 1 None None None 153004702 Common - Tetratricopeptide TPR_2 repeat protein Anae109_1840 102 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153004982 Common - chromosome segregation and condensation protein ScpA Anae109_2120 146 COG1354 COG1354, Uncharacterized conserved protein Function unknown 153007279 Common - HNH endonuclease Anae109_4442 3 COG1403 McrA, Restriction endonuclease Defense mechanisms 153002930 Common - beta-lactamase domain protein Anae109_0051 135 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 153002907 Common - aldo/keto reductase Anae109_0028 134 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 153004082 Common - NAD-dependent epimerase/dehydratase Anae109_1215 195 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153003235 Common - hypothetical protein Anae109_0361 40 COG3647 COG3647, Predicted membrane protein Function unknown 153003553 Common - ABC transporter related Anae109_0681 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 153006596 Common - MglA protein Anae109_3758 19 COG2229 COG2229, Predicted GTPase General function prediction only 153006000 Common - Hemerythrin HHE cation binding domain protein Anae109_3145 34 COG2461 COG2461, Uncharacterized conserved protein Function unknown 153002937 Common - O-methyltransferase family 3 Anae109_0058 83 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 153004694 Nonpathogen - hypothetical protein Anae109_1832 2 None None None 153003076 Common - Citrate (pro-3S)-lyase Anae109_0199 102 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 153005051 Common - hypothetical protein Anae109_2190 4 None None None 153005243 Common - heavy metal efflux pump, CzcA family Anae109_2382 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 153005099 Common - protein of unknown function DUF493 Anae109_2238 12 COG2921 COG2921, Uncharacterized conserved protein Function unknown 153005605 Nonpathogen - hypothetical protein Anae109_2745 1 None None None 153005101 Common - diguanylate cyclase Anae109_2240 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153006653 Common - heat shock protein DnaJ domain protein Anae109_3815 115 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 153004051 Common - response regulator receiver modulated metal dependent phosphohydrolase Anae109_1184 152 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 153003563 Nonpathogen - hypothetical protein Anae109_0691 1 None None None 153006832 Nonpathogen - Domain of unknown function DUF1863 Anae109_3995 3 None None None 153003650 Nonpathogen - hypothetical protein Anae109_0779 2 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 153003373 Common - protein of unknown function DUF302 Anae109_0500 45 COG3439 COG3439, Uncharacterized conserved protein Function unknown 153003919 Common - NADH dehydrogenase Anae109_1051 165 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 153006120 Nonpathogen - hypothetical protein Anae109_3268 1 None None None 153003655 Common - putative transcriptional regulator, AsnC family Anae109_0784 65 COG1522 Lrp, Transcriptional regulators Transcription 153005295 Nonpathogen - twin-arginine translocation protein, TatA/E family subunit Anae109_2435 3 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 153005411 Common - Haloacid dehalogenase domain protein hydrolase Anae109_2551 7 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 153006091 Common - Bile acid:sodium symporter Anae109_3238 8 COG0385 COG0385, Predicted Na+-dependent transporter General function prediction only 153006211 Common - signal recognition particle protein Anae109_3368 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 153006749 Common - zinc/iron permease Anae109_3911 58 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 153005911 Nonpathogen - hypothetical protein Anae109_3055 1 None None None 153004013 Common - Polyribonucleotide nucleotidyltransferase Anae109_1146 240 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 153006337 Nonpathogen - hypothetical protein Anae109_3495 4 None None None 153007090 Common - Fibronectin type III domain protein Anae109_4253 33 COG3401 COG3401, Fibronectin type 3 domain-containing protein General function prediction only 153003492 Common - integral membrane sensor signal transduction histidine kinase Anae109_0620 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153005197 Common - protein of unknown function DUF147 Anae109_2336 48 COG1624 COG1624, Uncharacterized conserved protein Function unknown 153005396 Common - aminodeoxychorismate lyase Anae109_2536 179 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 153005044 Common - succinyl-CoA synthetase, alpha subunit Anae109_2183 206 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 153005595 Common - Beta-ketoacyl synthase Anae109_2735 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153004341 Nonpathogen - putative CheW protein Anae109_1475 1 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153005683 Nonpathogen - hypothetical protein Anae109_2824 1 None None None 153004347 Nonpathogen - tetratricopeptide repeat protein Anae109_1481 1 None None None 153006848 Common - UvrD/REP helicase Anae109_4011 157 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 153003139 Common - TfoX domain protein Anae109_0262 28 COG3070 TfoX, Regulator of competence-specific genes Transcription 153004849 Nonpathogen - LigA Anae109_1987 1 None None None 153006868 Common - putative PAS/PAC sensor protein Anae109_4031 73 COG4564 COG4564, Signal transduction histidine kinase Signal transduction mechanisms 153006503 Common - transcriptional regulator, LysR family Anae109_3664 139 COG0583 LysR, Transcriptional regulator Transcription 153007005 Common - Ribosomal small subunit Rsm22 Anae109_4168 8 COG5459 COG5459, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 153003689 Common - adenylylsulfate kinase Anae109_0819 36 COG0529 CysC, Adenylylsulfate kinase and related kinases Inorganic ion transport and metabolism 153004872 Common - formate dehydrogenase, gamma subunit Anae109_2010 60 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 153005182 Common - protein of unknown function DUF1568 Anae109_2321 26 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 153005621 Nonpathogen - cytochrome C family protein Anae109_2762 4 None None None 153003159 Common - heat shock protein DnaJ domain protein Anae109_0282 121 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 153005847 Nonpathogen - HNH nuclease Anae109_2991 1 None None None 153003249 Common - glutamine amidotransferase of anthranilate synthase Anae109_0375 236 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 153006408 Common - hypothetical protein Anae109_3568 11 None None None 153003202 Common - Leucyl aminopeptidase Anae109_0328 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 153006372 Common - response regulator receiver modulated CheB methylesterase Anae109_3532 198 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 153006441 Common - short-chain dehydrogenase/reductase SDR Anae109_3601 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153005560 Nonpathogen - hypothetical protein Anae109_2700 1 None None None 153003332 Common - putative cold-shock DNA-binding domain protein Anae109_0458 21 COG1278 CspC, Cold shock proteins Transcription 153006118 Common - hypothetical protein Anae109_3266 8 None None None 153007072 Common - carbon starvation protein CstA Anae109_4235 109 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 153004324 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Anae109_1458 2 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 153005908 Common - hemerythrin-like metal-binding protein Anae109_3052 12 COG2703 COG2703, Hemerythrin Inorganic ion transport and metabolism 153005386 Common - methylglyoxal synthase Anae109_2526 88 COG1803 MgsA, Methylglyoxal synthase Carbohydrate transport and metabolism 153004073 Common - Methyltransferase type 11 Anae109_1206 13 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 153003006 Common - Carboxypeptidase Taq Anae109_0129 81 COG2317 COG2317, Zn-dependent carboxypeptidase Amino acid transport and metabolism 153004777 Common - ribosomal protein S19 Anae109_1915 243 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 153006190 Common - transcriptional activator domain Anae109_3347 47 COG3899 COG3899, Predicted ATPase General function prediction only 153006542 Common - 1-deoxy-D-xylulose 5-phosphate reductoisomerase Anae109_3704 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 153003269 Common - Biopolymer transport protein ExbD/TolR Anae109_0395 130 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 153004945 Nonpathogen - hypothetical protein Anae109_2083 1 COG3915 COG3915, Uncharacterized protein conserved in bacteria Function unknown 153005639 Common - Glycine cleavage T-protein barrel Anae109_2780 94 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 153005757 Common - Electron-transferring-flavoprotein dehydrogenase Anae109_2898 97 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 153006619 Common - NADH dehydrogenase (quinone) Anae109_3781 207 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 153004700 Nonpathogen - NHL repeat containing protein Anae109_1838 6 None None None 153003518 Common - putative CheW protein Anae109_0646 132 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153004253 Common - pyrroline-5-carboxylate reductase Anae109_1387 211 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 153005542 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Anae109_2682 3 None None None 153003464 Common - YhhN family protein Anae109_0591 29 COG3714 COG3714, Predicted membrane protein Function unknown 153006610 Common - hypothetical protein Anae109_3772 50 COG2261 COG2261, Predicted membrane protein Function unknown 153002881 Common - DNA polymerase III, beta subunit Anae109_0002 216 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 153006309 Common - methyl-accepting chemotaxis sensory transducer Anae109_3466 85 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153003336 Common - glucosamine--fructose-6-phosphate aminotransferase, isomerizing Anae109_0462 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 153005665 Common - Activator of Hsp90 ATPase 1 family protein Anae109_2806 43 COG3832 COG3832, Uncharacterized conserved protein Function unknown 153007079 Common - sigma54 specific transcriptional regulator, Fis family Anae109_4242 171 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 153005091 Common - RNA methyltransferase, TrmH family, group 3 Anae109_2230 215 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 153006460 Nonpathogen - hypothetical protein Anae109_3620 1 None None None 153007063 Nonpathogen - DNA binding domain, excisionase family Anae109_4226 1 None None None 153006043 Common - histidine kinase Anae109_3188 215 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153003196 Common - tRNA--hydroxylase Anae109_0321 40 COG4445 MiaE, Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 153006390 Common - AlkA domain protein Anae109_3550 111 COG0122 AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 153006443 Common - uroporphyrin-III C-methyltransferase Anae109_3603 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 153006040 Nonpathogen - hypothetical protein Anae109_3185 1 None None None 153007239 Common - hypothetical protein Anae109_4402 13 COG4427 COG4427, Uncharacterized protein conserved in bacteria Function unknown 153005139 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_2278 159 COG1146 COG1146, Ferredoxin Energy production and conversion 153004526 Common - binding-protein-dependent transport systems inner membrane component Anae109_1663 144 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 153006348 Nonpathogen - hypothetical protein Anae109_3506 1 None None None 153003508 Common - cytochrome c biogenesis protein transmembrane region Anae109_0636 189 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 153004189 Common - preprotein translocase, YajC subunit Anae109_1322 94 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 153002959 Common - magnesium transporter Anae109_0080 173 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 153004055 Common - thioesterase superfamily protein Anae109_1188 138 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 153004534 Common - histidine kinase Anae109_1671 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153004355 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_1489 174 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153004425 Common - GCN5-related N-acetyltransferase Anae109_1562 59 COG0456 RimI, Acetyltransferases General function prediction only 153002973 Common - MiaB-like tRNA modifying enzyme YliG Anae109_0094 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 153004418 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_1554 155 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153004660 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_1798 223 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153003181 Nonpathogen - hypothetical protein Anae109_0306 1 None None None 153003296 Common - phosphate uptake regulator, PhoU Anae109_0422 199 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 153004140 Common - heat shock protein DnaJ domain protein Anae109_1273 86 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 153005720 Common - Cytochrome-c oxidase Anae109_2861 166 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 153007280 Common - dTDP-glucose 4,6-dehydratase Anae109_4443 232 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 153004319 Common - inner-membrane translocator Anae109_1453 137 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 153003761 Common - ABC transporter related Anae109_0893 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 153004958 Common - aldo/keto reductase Anae109_2096 183 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 153004460 Common - histidine kinase Anae109_1597 217 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153004561 Common - YCII-related Anae109_1698 5 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 153004103 Common - polysaccharide biosynthesis protein Anae109_1236 106 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 153005502 Nonpathogen - Endonuclease/exonuclease/phosphatase Anae109_2642 3 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 153006911 Common - glycoside hydrolase family 3 domain protein Anae109_4074 156 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 153006278 Common - phospholipase D/Transphosphatidylase Anae109_3435 145 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 153007213 Common - histidine kinase Anae109_4376 222 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153006705 Common - sodium/hydrogen exchanger Anae109_3867 10 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 153005582 Common - HNH nuclease Anae109_2722 3 None None None 153005640 Nonpathogen - hypothetical protein Anae109_2781 1 None None None 153004220 Common - 6-pyruvoyl tetrahydropterin synthase and hypothetical protein Anae109_1354 112 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 153005777 Common - protein kinase Anae109_2918 136 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153006578 Common - Threonine aldolase Anae109_3740 81 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 153003571 Common - surface antigen (D15) Anae109_0699 148 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 153004113 Nonpathogen - hypothetical protein Anae109_1246 9 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153004110 Common - sugar transferase Anae109_1243 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 153004160 Common - NADH dehydrogenase (quinone) Anae109_1293 191 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 153005968 Common - 4-oxalocrotonate tautomerase Anae109_3113 34 COG1942 COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog General function prediction only 153006427 Common - ATP--cobalamin adenosyltransferase Anae109_3587 128 COG2096 COG2096, Uncharacterized conserved protein Function unknown 153003600 Common - general secretion pathway protein F Anae109_0728 149 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 153003986 Common - ABC transporter related Anae109_1119 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 153003972 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_1105 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153004853 Common - response regulator receiver modulated metal dependent phosphohydrolase Anae109_1991 217 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 153003325 Nonpathogen - hypothetical protein Anae109_0451 1 None None None 153004793 Common - preprotein translocase, SecY subunit Anae109_1931 228 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 153006589 Common - Mg chelatase, subunit ChlI Anae109_3751 192 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 153003178 Common - poly(A) polymerase Anae109_0303 201 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 153003849 Common - cytochrome bd ubiquinol oxidase subunit I Anae109_0981 167 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 153004407 Common - plasmid maintenance system antidote protein, XRE family Anae109_1543 77 COG3093 VapI, Plasmid maintenance system antidote protein General function prediction only 153002995 Common - peptidase S9 prolyl oligopeptidase active site domain protein Anae109_0118 179 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 153003604 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_0732 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153005056 Nonpathogen - hypothetical protein Anae109_2195 1 None None None 153004577 Common - transport-associated Anae109_1714 13 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 153006556 Nonpathogen - hypothetical protein Anae109_3718 1 None None None 153006482 Common - arsenical-resistance protein Anae109_3643 136 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 153003994 Nonpathogen - hypothetical protein Anae109_1127 1 None None None 153005375 Common - ribosomal protein L28 Anae109_2515 132 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 153005990 Common - Pirin domain protein Anae109_3135 147 COG1741 COG1741, Pirin-related protein General function prediction only 153005126 Common - hypothetical protein Anae109_2265 16 None None None 153003417 Nonpathogen - hypothetical protein Anae109_0544 1 None None None 153004960 Common - ATP-dependent protease La Anae109_2098 221 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 153005253 Common - AMP-dependent synthetase and ligase Anae109_2392 219 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 153005744 Common - PEBP family protein Anae109_2885 126 COG1881 COG1881, Phospholipid-binding protein General function prediction only 153004532 Common - Hemerythrin HHE cation binding domain protein Anae109_1669 25 COG2461 COG2461, Uncharacterized conserved protein Function unknown 153006664 Common - protein of unknown function DUF294 nucleotidyltransferase putative Anae109_3826 62 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 153006877 Common - Thioredoxin domain Anae109_4040 73 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 153005469 Common - polysaccharide deacetylase Anae109_2609 49 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 153002900 Nonpathogen - hypothetical protein Anae109_0021 1 None None None 153003146 Nonpathogen - RDD domain containing protein Anae109_0269 1 COG1714 COG1714, Predicted membrane protein/domain Function unknown 153007035 Common - glycosyl transferase family 2 Anae109_4198 210 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 153004411 Common - hypothetical protein Anae109_1547 20 COG3861 COG3861, Uncharacterized protein conserved in bacteria Function unknown 153003933 Common - hypothetical protein Anae109_1066 4 None None None 153003095 Common - GTP-binding protein HSR1-related Anae109_0218 222 COG2262 HflX, GTPases General function prediction only 153007275 Nonpathogen - polysaccharide biosynthesis protein Anae109_4438 1 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 153006361 Common - Polysulphide reductase NrfD Anae109_3521 33 COG5557 COG5557, Polysulphide reductase Energy production and conversion 153006249 Nonpathogen - FG-GAP repeat protein Anae109_3406 1 None None None 153004712 Common - response regulator receiver protein Anae109_1850 222 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153003830 Common - hypothetical protein Anae109_0962 3 None None None 153006134 Nonpathogen - hypothetical protein Anae109_3286 2 None None None 153002889 Nonpathogen - hypothetical protein Anae109_0010 1 COG5373 COG5373, Predicted membrane protein Function unknown 153004486 Common - hypothetical protein Anae109_1623 3 COG1409 Icc, Predicted phosphohydrolases General function prediction only 153006804 Common - Flp pilus assembly protein ATPase CpaE-like protein Anae109_3967 27 COG4963 CpaE, Flp pilus assembly protein, ATPase CpaE Intracellular trafficking and secretion 153007117 Nonpathogen - hypothetical protein Anae109_4280 1 None None None 153003013 Common - diguanylate cyclase Anae109_0136 166 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153005880 Common - nitrogenase cofactor biosynthesis protein NifB Anae109_3024 93 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 153003313 Common - hypothetical protein Anae109_0439 8 None None None 153002967 Common - Radical SAM domain protein Anae109_0088 94 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 153004481 Common - ABC-2 type transporter Anae109_1618 26 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 153004286 Nonpathogen - hypothetical protein Anae109_1420 2 COG5373 COG5373, Predicted membrane protein Function unknown 153007055 Common - oxidoreductase molybdopterin binding Anae109_4218 126 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 153005634 Nonpathogen - NUDIX hydrolase Anae109_2775 1 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 153007092 Common - TonB-dependent receptor Anae109_4255 95 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 153005694 Nonpathogen - hypothetical protein Anae109_2835 1 COG4196 COG4196, Uncharacterized protein conserved in bacteria Function unknown 153006841 Common - hypothetical protein Anae109_4004 15 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 153006417 Nonpathogen - hypothetical protein Anae109_3577 3 None None None 153006268 Common - ribonuclease PH Anae109_3425 181 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 153006544 Common - undecaprenyl diphosphate synthase Anae109_3706 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 153006724 Common - UDP-N-acetylenolpyruvoylglucosamine reductase Anae109_3886 197 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 153006158 Common - aldo/keto reductase Anae109_3314 198 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 153005918 Nonpathogen - hypothetical protein Anae109_3063 1 None None None 153006066 Common - Nucleotidyl transferase Anae109_3212 34 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 153006058 Common - cyclic nucleotide-binding protein Anae109_3203 44 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 153005114 Nonpathogen - LigA Anae109_2253 1 COG3846 TrbL, Type IV secretory pathway, TrbL components Intracellular trafficking and secretion 153003961 Common - tyrosyl-tRNA synthetase Anae109_1094 235 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153004506 Common - sulfate adenylyltransferase, large subunit Anae109_1643 249 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 153003029 Common - uncharacterised P-loop ATPase protein UPF0042 Anae109_0152 140 COG1660 COG1660, Predicted P-loop-containing kinase General function prediction only 153003363 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_0489 130 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153003399 Common - hydrogenase (NiFe) small subunit HydA Anae109_0526 77 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 153005572 Common - metal dependent phosphohydrolase Anae109_2712 56 COG1480 COG1480, Predicted membrane-associated HD superfamily hydrolase General function prediction only 153005075 Nonpathogen - hypothetical protein Anae109_2214 1 None None None 153004092 Common - heavy metal translocating P-type ATPase Anae109_1225 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 153003437 Common - protein of unknown function DUF323 Anae109_0564 96 COG1262 COG1262, Uncharacterized conserved protein Function unknown 153005271 Common - Abortive infection protein Anae109_2411 19 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 153003542 Common - signal transduction histidine kinase, nitrogen specific, NtrB Anae109_0670 222 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 153004431 Common - molecular chaperone-like protein Anae109_1568 190 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 153005011 Common - NmrA family protein Anae109_2150 52 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153005037 Nonpathogen - restriction endonuclease Anae109_2176 3 None None None 153007345 Common - ribonuclease P protein component Anae109_4508 4 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 153005786 Common - hypothetical protein Anae109_2927 5 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 153003288 Common - outer membrane protein, OmpA/MotB family Anae109_0414 15 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 153005985 Common - hypothetical protein Anae109_3130 9 None None None 153005033 Common - thioesterase superfamily protein Anae109_2172 148 COG0824 FcbC, Predicted thioesterase General function prediction only 153006194 Common - metallophosphoesterase Anae109_3351 77 COG0622 COG0622, Predicted phosphoesterase General function prediction only 153005944 Nonpathogen - hypothetical protein Anae109_3089 1 None None None 153006502 Nonpathogen - hypothetical protein Anae109_3663 2 None None None 153005982 Nonpathogen - anti-sigma-factor antagonist Anae109_3127 1 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 153006624 Common - NADH ubiquinone oxidoreductase 20 kDa subunit Anae109_3786 196 COG3260 COG3260, Ni,Fe-hydrogenase III small subunit Energy production and conversion 153007207 Common - Threonyl/alanyl tRNA synthetase SAD Anae109_4370 179 COG2872 COG2872, Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain General function prediction only 153007099 Common - outer membrane efflux protein Anae109_4262 27 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 153006199 Common - short-chain dehydrogenase/reductase SDR Anae109_3356 222 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 153005735 Common - acetyl-CoA acetyltransferase Anae109_2876 174 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 153004909 Nonpathogen - hypothetical protein Anae109_2047 2 None None None 153005001 Common - GTP cyclohydrolase II Anae109_2140 203 COG0807 RibA, GTP cyclohydrolase II Coenzyme metabolism 153005032 Common - fructose-1,6-bisphosphatase, class II Anae109_2171 112 COG1494 GlpX, Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins Carbohydrate transport and metabolism 153005135 Common - SirA-like protein Anae109_2274 26 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 153004896 Common - hypothetical protein Anae109_2034 10 COG4832 COG4832, Uncharacterized conserved protein Function unknown 153005817 Common - efflux transporter, RND family, MFP subunit Anae109_2959 44 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 153003718 Common - Cytochrome c oxidase subunit II Anae109_0848 160 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 153004318 Common - ABC transporter related Anae109_1452 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 153004623 Nonpathogen - type II and III secretion system protein domain protein Anae109_1761 1 None None None 153006831 Common - hypothetical protein Anae109_3994 7 COG4923 COG4923, Uncharacterized conserved protein Function unknown 153006747 Common - putative TIM-barrel protein, nifR3 family Anae109_3909 200 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 153006399 Nonpathogen - hypothetical protein Anae109_3559 1 None None None 153004630 Nonpathogen - hypothetical protein Anae109_1768 1 None None None 153005647 Nonpathogen - hypothetical protein Anae109_2788 2 None None None 153007089 Common - response regulator receiver protein Anae109_4252 219 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153004883 Common - UvrD/REP helicase Anae109_2021 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 153004801 Common - ribosomal protein L17 Anae109_1939 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 153003280 Common - DEAD/H associated domain protein Anae109_0406 139 COG1201 Lhr, Lhr-like helicases General function prediction only 153003727 Common - protein of unknown function DUF748 Anae109_0857 43 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 153007330 Common - DNA gyrase, A subunit Anae109_4493 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 153005433 Common - Guanylate kinase Anae109_2573 213 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 153004038 Nonpathogen - protein of unknown function DUF6 transmembrane Anae109_1171 1 COG2510 COG2510, Predicted membrane protein Function unknown 153003223 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Anae109_0349 113 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 153005205 Nonpathogen - type IV pilus assembly PilZ Anae109_2344 1 None None None 153006511 Common - glutamine amidotransferase class-I Anae109_3672 120 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 153006495 Common - transcriptional regulator, TetR family Anae109_3656 86 COG1309 AcrR, Transcriptional regulator Transcription 153007016 Nonpathogen - hypothetical protein Anae109_4179 1 None None None 153003445 Common - Inorganic pyrophosphatase Anae109_0572 182 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 153007164 Common - ribosomal protein L27 Anae109_4327 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 153004083 Nonpathogen - hypothetical protein Anae109_1216 1 None None None 153007258 Common - protein of unknown function DUF58 Anae109_4421 103 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 153004308 Common - Radical SAM domain protein Anae109_1442 5 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 153006387 Common - TPR repeat-containing protein Anae109_3547 14 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 153003671 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Anae109_0801 36 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 153005359 Common - DNA internalization-related competence protein ComEC/Rec2 Anae109_2499 123 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 153007198 Common - response regulator receiver modulated PilZ sensor protein Anae109_4361 46 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153003155 Common - histidine kinase Anae109_0278 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153005579 Common - leucyl-tRNA synthetase Anae109_2719 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153006682 Common - major facilitator superfamily MFS_1 Anae109_3844 212 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153006797 Nonpathogen - hypothetical protein Anae109_3960 10 None None None 153006522 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Anae109_3684 206 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 153003349 Common - DSBA oxidoreductase Anae109_0475 119 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 153005657 Nonpathogen - DNA binding domain, excisionase family Anae109_2798 1 None None None 153003216 Nonpathogen - hypothetical protein Anae109_0342 1 None None None 153004731 Nonpathogen - PKD domain containing protein Anae109_1869 1 None None None 153007337 Common - protein of unknown function DUF583 Anae109_4500 69 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 153006768 Common - Tetratricopeptide TPR_2 repeat protein Anae109_3930 18 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153003595 Nonpathogen - hypothetical protein Anae109_0723 3 COG3156 PulK, Type II secretory pathway, component PulK Intracellular trafficking and secretion 153005489 Common - polysaccharide biosynthesis protein Anae109_2629 3 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 153006123 Nonpathogen - hypothetical protein Anae109_3273 1 None None None 153006839 Nonpathogen - hypothetical protein Anae109_4002 1 None None None 153006808 Nonpathogen - peptidase A24A prepilin type IV Anae109_3971 1 COG4960 CpaA, Flp pilus assembly protein, protease CpaA Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 153003171 Common - ribosomal protein S2 Anae109_0295 239 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 153003590 Common - signal recognition particle-docking protein FtsY Anae109_0718 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 153004009 Common - protein of unknown function DUF503 Anae109_1142 39 COG1550 COG1550, Uncharacterized protein conserved in bacteria Function unknown 153003822 Nonpathogen - hypothetical protein Anae109_0954 1 None None None 153005705 Common - peptidase M28 Anae109_2846 53 COG2234 Iap, Predicted aminopeptidases General function prediction only 153004312 Common - protein of unknown function DUF124 Anae109_1446 77 COG2013 COG2013, Uncharacterized conserved protein Function unknown 153005129 Common - hypothetical protein Anae109_2268 3 None None None 153004247 Common - PHP domain protein Anae109_1381 48 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 153003773 Common - FeS assembly protein SufD Anae109_0905 165 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 153006680 Common - hypothetical protein Anae109_3842 4 None None None 153007026 Common - DoxX family protein Anae109_4189 52 COG2259 COG2259, Predicted membrane protein Function unknown 153004976 Common - hypothetical protein Anae109_2114 6 None None None 153006901 Common - protein kinase Anae109_4064 149 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153005479 Nonpathogen - hypothetical protein Anae109_2619 1 None None None 153005026 Common - Enoyl-CoA hydratase/isomerase Anae109_2165 174 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 153003036 Common - Methionine adenosyltransferase Anae109_0159 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 153003752 Common - transcriptional regulator, TetR family Anae109_0884 36 COG1309 AcrR, Transcriptional regulator Transcription 153004724 Nonpathogen - hypothetical protein Anae109_1862 1 None None None 153007127 Common - Phosphatidylinositol alpha-mannosyltransferase Anae109_4290 141 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153003873 Nonpathogen - hypothetical protein Anae109_1005 1 None None None 153004816 Common - HNH endonuclease Anae109_1954 99 COG1403 McrA, Restriction endonuclease Defense mechanisms 153003857 Common - K potassium transporter Anae109_0989 88 COG3158 Kup, K+ transporter Inorganic ion transport and metabolism 153004041 Common - inner-membrane translocator Anae109_1174 143 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 153005456 Common - protein of unknown function DUF395 YeeE/YedE Anae109_2596 42 None None None 153006816 Nonpathogen - hypothetical protein Anae109_3979 2 None None None 153006678 Nonpathogen - hypothetical protein Anae109_3840 3 None None None 153004276 Common - UDP-N-acetylglucosamine 2-epimerase Anae109_1410 153 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 153006303 Common - peptidase U61 LD-carboxypeptidase A Anae109_3460 63 COG1619 LdcA, Uncharacterized proteins, homologs of microcin C7 resistance protein MccF Defense mechanisms 153007324 Common - ATP synthase F0, A subunit Anae109_4487 197 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 153003491 Common - peptidase M16 domain protein Anae109_0619 194 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 153006533 Nonpathogen - DNA binding domain, excisionase family Anae109_3695 4 COG2452 COG2452, Predicted site-specific integrase-resolvase DNA replication, recombination, and repair 153004102 Common - hypothetical protein Anae109_1235 12 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 153007270 Common - glycosyl transferase family 4 Anae109_4433 95 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 153005077 Common - ATPase, FliI/YscN family Anae109_2216 247 COG1157 FliI, Flagellar biosynthesis/type III secretory pathway ATPase Cell motility and secretion / Intracellular trafficking and secretion 153004400 Common - periplasmic solute binding protein Anae109_1535 64 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 153006290 Nonpathogen - hypothetical protein Anae109_3447 3 None None None 153006706 Common - ABC nitrate/sulfonate/bicarbonate transporter, periplasmic ligand binding protein Anae109_3868 16 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 153007155 Common - CTP synthase Anae109_4318 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 153003210 Common - Quinone oxidoreductase putative PIG3 Anae109_0336 167 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 153003524 Nonpathogen - hypothetical protein Anae109_0652 1 None None None 153003586 Common - glycosyl transferase family 2 Anae109_0714 154 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 153007128 Common - Inositol-3-phosphate synthase Anae109_4291 18 COG1260 INO1, Myo-inositol-1-phosphate synthase Lipid metabolism 153006821 Common - type III restriction protein res subunit Anae109_3984 181 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 153005525 Common - hypothetical protein Anae109_2665 12 None None None 153005136 Common - UBA/THIF-type NAD/FAD binding protein Anae109_2275 189 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 153005260 Common - methyl-accepting chemotaxis sensory transducer Anae109_2399 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153005795 Common - Tetratricopeptide TPR_2 repeat protein Anae109_2936 94 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153003966 Common - phosphoesterase RecJ domain protein Anae109_1099 53 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 153006891 Common - histidine kinase Anae109_4054 217 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153003309 Common - glycerophosphoryl diester phosphodiesterase Anae109_0435 49 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 153007243 Nonpathogen - hypothetical protein Anae109_4406 8 None None None 153004048 Common - hypothetical protein Anae109_1181 19 None None None 153003140 Common - putative oxygen-independent coproporphyrinogen III oxidase Anae109_0263 202 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 153004761 Nonpathogen - hypothetical protein Anae109_1899 3 None None None 153003421 Common - hemerythrin-like metal-binding protein Anae109_0548 30 COG2703 COG2703, Hemerythrin Inorganic ion transport and metabolism 153003456 Nonpathogen - hypothetical protein Anae109_0583 3 None None None 153004638 Common - serine/threonine protein kinase Anae109_1776 60 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153003503 Common - arginine repressor, ArgR Anae109_0631 80 COG1438 ArgR, Arginine repressor Transcription 153006329 Common - alanine racemase Anae109_3487 199 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 153005923 Common - histidine kinase Anae109_3068 84 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153003892 Common - acriflavin resistance protein Anae109_1024 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 153005806 Nonpathogen - PfkB domain protein Anae109_2948 4 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 153006055 Common - Tetratricopeptide TPR_2 repeat protein Anae109_3200 16 None None None 153004916 Common - OsmC family protein Anae109_2054 5 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 153005266 Common - Polysulphide reductase NrfD Anae109_2406 44 COG5557 COG5557, Polysulphide reductase Energy production and conversion 153004564 Common - protein of unknown function DUF454 Anae109_1701 86 COG2832 COG2832, Uncharacterized protein conserved in bacteria Function unknown 153005937 Common - protein of unknown function DUF6 transmembrane Anae109_3082 30 None None None 153007232 Common - histidine kinase Anae109_4395 189 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153003638 Nonpathogen - hypothetical protein Anae109_0767 1 None None None 153006286 Common - hypothetical protein Anae109_3443 16 None None None 153005169 Nonpathogen - hypothetical protein Anae109_2308 3 None None None 153006048 Nonpathogen - Hemerythrin HHE cation binding domain protein Anae109_3193 1 COG2846 COG2846, Regulator of cell morphogenesis and NO signaling Cell division and chromosome partitioning 153003388 Common - hydrogenase expression/formation protein HypE Anae109_0515 173 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 153006595 Nonpathogen - hypothetical protein Anae109_3757 2 None None None 153003043 Common - Phosphomannomutase Anae109_0166 243 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 153005025 Common - Propionyl-CoA carboxylase Anae109_2164 181 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 153003191 Nonpathogen - putative phosphohistidine phosphatase, SixA Anae109_0316 2 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 153006648 Common - deoxynucleoside kinase Anae109_3810 39 COG1428 COG1428, Deoxynucleoside kinases Nucleotide transport and metabolism 153004438 Common - DNA binding domain, excisionase family Anae109_1575 41 COG1910 COG1910, Periplasmic molybdate-binding protein/domain Inorganic ion transport and metabolism 153003236 Common - class II aldolase/adducin family protein Anae109_0362 96 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 153003906 Common - hypothetical protein Anae109_1038 109 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 153004803 Common - ribosomal protein S16 Anae109_1941 213 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 153003153 Common - 1-acyl-sn-glycerol-3-phosphate acyltransferase Anae109_0276 197 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 153004685 Common - cytochrome C family protein Anae109_1823 11 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 153004583 Common - major facilitator superfamily MFS_1 Anae109_1720 76 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 153004722 Nonpathogen - hypothetical protein Anae109_1860 2 None None None 153005336 Common - Glycerol-3-phosphate O-acyltransferase Anae109_2476 47 COG2937 PlsB, Glycerol-3-phosphate O-acyltransferase Lipid metabolism 153005663 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Anae109_2804 93 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 153006026 Common - Methyltransferase type 11 Anae109_3171 76 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153004194 Common - single-stranded-DNA-specific exonuclease RecJ Anae109_1327 191 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 153005912 Common - Substrate-binding region of ABC-type glycine betaine transport system Anae109_3056 132 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 153002894 Common - prolipoprotein diacylglyceryl transferase Anae109_0015 202 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 153006818 Nonpathogen - DNA binding domain, excisionase family Anae109_3981 1 None None None 153003300 Nonpathogen - hypothetical protein Anae109_0426 2 None None None 153005218 Common - fatty acid desaturase Anae109_2357 31 COG3239 DesA, Fatty acid desaturase Lipid metabolism 153005828 Common - putative signal-transduction protein with CBS domains Anae109_2970 128 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 153004233 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Anae109_1367 109 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 153004001 Common - response regulator receiver protein Anae109_1134 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153006665 Nonpathogen - hypothetical protein Anae109_3827 1 None None None 153004249 Nonpathogen - Em-like protein GEA1 (EM1) Anae109_1383 2 None None None 153006746 Common - Lytic transglycosylase catalytic Anae109_3908 117 COG1388 LytE, FOG: LysM repeat Cell envelope biogenesis, outer membrane 153004641 Common - hypothetical protein Anae109_1779 4 None None None 153005391 Common - translation initiation factor IF-1 Anae109_2531 213 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 153003710 Common - hypothetical protein Anae109_0840 26 None None None 153007104 Common - copper-resistance protein, CopA family Anae109_4267 122 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 153004729 Common - CDP-alcohol phosphatidyltransferase Anae109_1867 13 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 153004582 Common - phosphoserine aminotransferase Anae109_1719 118 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 153006014 Common - L-aspartate oxidase Anae109_3159 226 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 153006226 Common - FHA domain containing protein Anae109_3383 22 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 153004607 Common - hypothetical protein Anae109_1745 8 COG3164 COG3164, Predicted membrane protein Function unknown 153006878 Nonpathogen - hypothetical protein Anae109_4041 1 None None None 153002929 Common - electron transfer flavoprotein alpha and beta subunits Anae109_0050 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 153003390 Common - hydrogenase assembly chaperone hypC/hupF Anae109_0517 95 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 153007025 Common - beta-lactamase domain protein Anae109_4188 45 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 153005105 Nonpathogen - hypothetical protein Anae109_2244 2 None None None 153003757 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_0889 218 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153007263 Nonpathogen - putative transmembrane anti-sigma factor Anae109_4426 1 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 153003392 Common - zinc finger HypF domain protein Anae109_0519 106 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 153002978 Common - Spore coat protein CotH Anae109_0099 13 COG5337 CotH, Spore coat assembly protein Cell envelope biogenesis, outer membrane 153003904 Common - Dinitrogenase iron-molybdenum cofactor biosynthesis protein Anae109_1036 24 COG1433 COG1433, Uncharacterized conserved protein Function unknown 153006904 Common - UspA domain protein Anae109_4067 89 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 153005239 Common - histidine kinase Anae109_2378 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153003618 Nonpathogen - hypothetical protein Anae109_0746 1 COG3190 FliO, Flagellar biogenesis protein Cell motility and secretion 153006773 Common - Cna B domain protein Anae109_3936 36 COG4932 COG4932, Predicted outer membrane protein Cell envelope biogenesis, outer membrane 153004076 Nonpathogen - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_1209 7 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 153004280 Common - uncharacterised conserved protein UCP033563 Anae109_1414 50 COG4198 COG4198, Uncharacterized conserved protein Function unknown 153004003 Common - deoxyxylulose-5-phosphate synthase Anae109_1136 226 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 153004592 Common - hypothetical protein Anae109_1730 30 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 153007045 Common - amidohydrolase Anae109_4208 25 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 153005512 Nonpathogen - hypothetical protein Anae109_2652 1 None None None 153006471 Common - response regulator receiver protein Anae109_3631 141 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153006490 Common - alkylhydroperoxidase like protein, AhpD family Anae109_3651 63 COG2128 COG2128, Uncharacterized conserved protein Function unknown 153003769 Common - hypothetical protein Anae109_0901 49 COG4681 COG4681, Uncharacterized protein conserved in bacteria Function unknown 153004848 Common - Extracellular HAF Anae109_1986 17 COG5563 COG5563, Predicted integral membrane proteins containing uncharacterized repeats Function unknown 153006518 Common - hypothetical protein Anae109_3679 91 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 153006271 Common - Tetratricopeptide TPR_2 repeat protein Anae109_3428 134 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153004658 Common - histidine kinase Anae109_1796 223 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153005325 Nonpathogen - hypothetical protein Anae109_2465 2 None None None 153006481 Common - protein tyrosine phosphatase Anae109_3642 140 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 153007228 Common - phospholipase D/Transphosphatidylase Anae109_4391 142 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 153003948 Nonpathogen - phage transcriptional regulator, AlpA Anae109_1081 1 COG3311 AlpA, Predicted transcriptional regulator Transcription 153006436 Common - nitrate reductase, beta subunit Anae109_3596 145 COG1140 NarY, Nitrate reductase beta subunit Energy production and conversion 153006655 Common - Protein phosphatase 2C-like protein Anae109_3817 137 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 153003438 Nonpathogen - glycosyl transferase group 1 Anae109_0565 8 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153004739 Common - acetolactate synthase, large subunit, biosynthetic type Anae109_1877 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 153005844 Nonpathogen - hypothetical protein Anae109_2986 1 None None None 153003088 Common - hypothetical protein Anae109_0211 2 None None None 153004866 Nonpathogen - hypothetical protein Anae109_2004 5 None None None 153006694 Common - Methyltransferase type 11 Anae109_3856 54 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153007135 Common - protein of unknown function DUF214 Anae109_4298 166 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 153003063 Common - ABC transporter related Anae109_0186 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 153003479 Common - filamentation induced by cAMP protein Fic Anae109_0607 102 COG3177 COG3177, Uncharacterized conserved protein Function unknown 153004156 Common - NADH-ubiquinone/plastoquinone oxidoreductase chain 3 Anae109_1289 161 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 153006811 Common - short-chain dehydrogenase/reductase SDR Anae109_3974 231 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 153004442 Common - Rhomboid family protein Anae109_1579 149 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 153006997 Common - histidine kinase Anae109_4160 222 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 153007074 Nonpathogen - hypothetical protein Anae109_4237 1 None None None 153004587 Common - DEAD/H associated domain protein Anae109_1724 161 COG1201 Lhr, Lhr-like helicases General function prediction only 153003409 Common - P pilus assembly protein chaperone PapD-like protein Anae109_0536 15 COG3121 FimC, P pilus assembly protein, chaperone PapD Cell motility and secretion / Intracellular trafficking and secretion 153003123 Common - Carbohydrate-binding and sugar hydrolysis Anae109_0246 49 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 153003208 Nonpathogen - polysaccharide biosynthesis protein Anae109_0334 2 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 153005177 Common - imidazolonepropionase Anae109_2316 98 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 153004845 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Anae109_1983 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 153005604 Nonpathogen - hypothetical protein Anae109_2744 6 None None None 153006244 Nonpathogen - hypothetical protein Anae109_3401 2 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 153003663 Common - GAF sensor signal transduction histidine kinase Anae109_0792 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153006180 Common - PRC-barrel domain protein Anae109_3337 29 COG1873 COG1873, Uncharacterized conserved protein Function unknown 153006964 Common - pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase Anae109_4127 198 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 153004227 Nonpathogen - hypothetical protein Anae109_1361 3 None None None 153003106 Nonpathogen - cytochrome C family protein Anae109_0229 2 None None None 153005267 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_2407 165 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153004557 Common - ABC transporter related Anae109_1694 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 153004608 Nonpathogen - Peptidoglycan-binding domain 1 protein Anae109_1746 1 None None None 153005387 Nonpathogen - TonB family protein Anae109_2527 2 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 153006122 Common - SEC-C motif domain protein Anae109_3272 10 COG3318 COG3318, Predicted metal-binding protein related to the C-terminal domain of SecA General function prediction only 153004385 Common - transferase hexapeptide repeat Anae109_1520 187 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 153005052 Common - carbamoyl-phosphate synthase, small subunit Anae109_2191 233 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 153003429 Common - peptidase M48 Ste24p Anae109_0556 94 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 153005278 Common - Ferritin Dps family protein Anae109_2418 83 COG1528 Ftn, Ferritin-like protein Inorganic ion transport and metabolism 153004575 Common - hypothetical protein Anae109_1712 18 COG1333 ResB, ResB protein required for cytochrome c biosynthesis Posttranslational modification, protein turnover, chaperones 153004176 Common - transcriptional regulator, TraR/DksA family Anae109_1309 161 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 153003059 Common - Radical SAM domain protein Anae109_0182 166 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 153006950 Common - thiamine pyrophosphate protein domain protein TPP-binding Anae109_4113 109 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 153005308 Common - hydrolase, TatD family Anae109_2448 234 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 153006353 Common - hypothetical protein Anae109_3511 5 None None None 153007000 Common - acetyl-CoA acetyltransferase Anae109_4163 183 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 153003842 Common - Cobyrinic acid ac-diamide synthase Anae109_0974 195 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 153005227 Common - response regulator receiver modulated CheB methylesterase Anae109_2366 206 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 153004507 Common - sulfate adenylyltransferase, small subunit Anae109_1644 123 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 153006208 Common - response regulator receiver protein Anae109_3365 215 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153004930 Nonpathogen - hypothetical protein Anae109_2068 1 None None None 153003879 Common - protein of unknown function DUF81 Anae109_1011 88 COG0730 COG0730, Predicted permeases General function prediction only 153005482 Common - Undecaprenyl-phosphate galactose phosphotransferase Anae109_2622 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 153006253 Common - aminotransferase class I and II Anae109_3410 200 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 153006092 Nonpathogen - hypothetical protein Anae109_3239 1 None None None 153003532 Common - response regulator receiver protein Anae109_0660 215 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153003559 Common - Fimbrial assembly family protein Anae109_0687 36 COG3166 PilN, Tfp pilus assembly protein PilN Cell motility and secretion / Intracellular trafficking and secretion 153006458 Common - hypothetical protein Anae109_3618 29 COG3875 COG3875, Uncharacterized conserved protein Function unknown 153007301 Common - methyl-accepting chemotaxis sensory transducer Anae109_4464 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153005018 Common - Peptidylprolyl isomerase Anae109_2157 192 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 153003565 Common - translation elongation factor P Anae109_0693 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 153006101 Nonpathogen - LigA Anae109_3249 1 None None None 153003880 Common - response regulator receiver protein Anae109_1012 217 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153004061 Common - AhpC/TSA family protein Anae109_1194 8 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 153005098 Nonpathogen - hypothetical protein Anae109_2237 3 None None None 153004981 Common - tryptophanyl-tRNA synthetase Anae109_2119 235 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153004701 Common - NHL repeat domain protein Anae109_1839 6 COG3391 COG3391, Uncharacterized conserved protein Function unknown 153004269 Common - permease YjgP/YjgQ family protein Anae109_1403 21 COG0795 COG0795, Predicted permeases General function prediction only 153003674 Common - multi-sensor signal transduction histidine kinase Anae109_0804 221 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 153003019 Common - hypothetical protein Anae109_0142 19 None None None 153005100 Common - PhoH family protein Anae109_2239 199 COG1875 COG1875, Predicted ATPase related to phosphate starvation-inducible protein PhoH Signal transduction mechanisms 153003613 Common - type III secretion FHIPEP protein Anae109_0741 127 COG4789 EscV, Type III secretory pathway, component EscV Intracellular trafficking and secretion 153006184 Common - Ig domain protein group 2 domain protein Anae109_3341 13 None None None 153002980 Common - glucose-1-phosphate adenylyltransferase Anae109_0101 185 COG0448 GlgC, ADP-glucose pyrophosphorylase Carbohydrate transport and metabolism 153003397 Common - Polysulphide reductase NrfD Anae109_0524 28 COG5557 COG5557, Polysulphide reductase Energy production and conversion 153003133 Nonpathogen - hypothetical protein Anae109_0256 2 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 153003225 Common - OsmC family protein Anae109_0351 49 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 153004596 Common - protein of unknown function DUF88 Anae109_1734 82 COG1432 COG1432, Uncharacterized conserved protein Function unknown 153005086 Common - ribosomal protein L11 Anae109_2225 246 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 153005521 Common - protein of unknown function DUF898 transmembrane Anae109_2661 32 COG4269 COG4269, Predicted membrane protein Function unknown 153006235 Nonpathogen - type IV pilus assembly PilZ Anae109_3392 3 COG3215 PilZ, Tfp pilus assembly protein PilZ Cell motility and secretion / Intracellular trafficking and secretion 153003012 Common - glycoside hydrolase family 57 Anae109_0135 35 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 153003957 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_1090 123 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 153003740 Common - Biopolymer transport protein ExbD/TolR Anae109_0872 124 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 153003564 Nonpathogen - hypothetical protein Anae109_0692 6 None None None 153005992 Common - Exonuclease RNase T and DNA polymerase III Anae109_3137 102 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 153005779 Common - FAD linked oxidase domain protein Anae109_2920 152 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 153006675 Common - methyl-accepting chemotaxis sensory transducer Anae109_3837 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153003799 Common - hypothetical protein Anae109_0931 3 None None None 153007201 Common - hypothetical protein Anae109_4364 17 COG3359 COG3359, Predicted exonuclease DNA replication, recombination, and repair 153005839 Common - efflux transporter, RND family, MFP subunit Anae109_2981 114 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153003470 Common - glucose-6-phosphate 1-dehydrogenase Anae109_0597 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 153005812 Nonpathogen - response regulator receiver protein Anae109_2954 5 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153003748 Common - two component transcriptional regulator, winged helix family Anae109_0880 218 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153003625 Common - Histidinol dehydrogenase Anae109_0753 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 153003825 Nonpathogen - hypothetical protein Anae109_0957 1 None None None 153004394 Common - AMP-dependent synthetase and ligase Anae109_1529 216 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 153005156 Nonpathogen - putative CheW protein Anae109_2295 1 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153004797 Common - ribosomal protein S13 Anae109_1935 248 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 153003004 Common - 4-diphosphocytidyl-2C-methyl-D-erythritol kinase Anae109_0127 152 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 153005671 Common - Phosphoglycerate mutase Anae109_2812 131 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 153004950 Common - DNA mismatch repair protein MutL Anae109_2088 192 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 153002922 Common - thiamine pyrophosphate protein domain protein TPP-binding Anae109_0043 91 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 153004984 Common - pseudouridine synthase Anae109_2122 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 153005473 Common - protein of unknown function UPF0052 and CofD Anae109_2613 96 COG0391 COG0391, Uncharacterized conserved protein Function unknown 153004831 Common - HAD superfamily (subfamily IG) hydrolase, 5'-nucleotidase Anae109_1969 6 None None None 153005063 Nonpathogen - hypothetical protein Anae109_2202 2 COG4544 COG4544, Uncharacterized conserved protein Function unknown 153003931 Common - Activator of Hsp90 ATPase 1 family protein Anae109_1064 16 COG3832 COG3832, Uncharacterized conserved protein Function unknown 153006898 Common - malate synthase Anae109_4061 55 COG2225 AceB, Malate synthase Energy production and conversion 153003329 Nonpathogen - hypothetical protein Anae109_0455 2 None None None 153003781 Common - peptidase S1 and S6 chymotrypsin/Hap Anae109_0913 215 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 153004288 Common - hypothetical protein Anae109_1422 8 COG2342 COG2342, Predicted extracellular endo alpha-1,4 polygalactosaminidase or related polysaccharide hydrolase Carbohydrate transport and metabolism 153006973 Common - Vault protein inter-alpha-trypsin domain protein Anae109_4136 31 COG2304 COG2304, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 153006712 Common - protein of unknown function UPF0040 Anae109_3874 139 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 153006828 Common - hypothetical protein Anae109_3991 9 None None None 153004697 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Anae109_1835 18 None None None 153004646 Nonpathogen - hypothetical protein Anae109_1784 2 None None None 153004464 Common - Methyltransferase type 11 Anae109_1601 54 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153004893 Nonpathogen - hypothetical protein Anae109_2031 8 None None None 153005220 Common - Radical SAM domain protein Anae109_2359 41 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 153003481 Nonpathogen - hypothetical protein Anae109_0609 1 None None None 153005422 Common - V-type ATPase, D subunit Anae109_2562 39 COG1394 NtpD, Archaeal/vacuolar-type H+-ATPase subunit D Energy production and conversion 153006189 Common - peptidase M61 domain protein Anae109_3346 56 COG3975 COG3975, Predicted protease with the C-terminal PDZ domain General function prediction only 153004859 Common - UBA/THIF-type NAD/FAD binding protein Anae109_1997 136 COG1179 COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Coenzyme metabolism 153002912 Common - membrane protein involved in aromatic hydrocarbon degradation Anae109_0033 31 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 153006298 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Anae109_3455 152 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 153004750 Common - GTP cyclohydrolase I Anae109_1888 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 153004810 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Anae109_1948 207 COG0313 COG0313, Predicted methyltransferases General function prediction only 153003359 Common - glycosyl transferase family 28 Anae109_0485 36 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 153004056 Common - FHA domain containing protein Anae109_1189 32 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 153004974 Common - metal dependent phosphohydrolase Anae109_2112 123 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 153006917 Common - Squalene/phytoene synthase Anae109_4080 103 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 153007181 Nonpathogen - hypothetical protein Anae109_4344 1 None None None 153003938 Common - hypothetical protein Anae109_1071 6 COG5340 COG5340, Predicted transcriptional regulator Transcription 153007294 Common - multi-sensor signal transduction histidine kinase Anae109_4457 222 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153004334 Common - Cupin 2 conserved barrel domain protein Anae109_1468 45 COG3837 COG3837, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 153003147 Nonpathogen - General secretory system II protein E domain protein Anae109_0270 3 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 153004036 Common - oligoendopeptidase F Anae109_1169 85 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 153003022 Common - DNA-directed DNA polymerase Anae109_0145 184 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 153006131 Nonpathogen - hypothetical protein Anae109_3283 3 None None None 153005493 Common - DegT/DnrJ/EryC1/StrS aminotransferase Anae109_2633 192 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 153004452 Common - malate dehydrogenase, NAD-dependent Anae109_1589 195 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 153003837 Nonpathogen - hypothetical protein Anae109_0969 2 None None None 153006178 Common - ThiJ/PfpI domain protein Anae109_3335 135 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 153003619 Nonpathogen - type III secretion system apparatus protein YscQ/HrcQ Anae109_0747 1 COG1868 FliM, Flagellar motor switch protein Cell motility and secretion 153003782 Nonpathogen - hypothetical protein Anae109_0914 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 153005550 Nonpathogen - hypothetical protein Anae109_2690 2 None None None 153006396 Common - threonine dehydratase Anae109_3556 218 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 153004205 Nonpathogen - hypothetical protein Anae109_1338 1 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 153005194 Common - pyridoxal phosphate biosynthetic protein PdxJ Anae109_2333 139 COG0854 PdxJ, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 153004356 Nonpathogen - Radical SAM domain protein Anae109_1490 11 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 153006523 Common - Tetratricopeptide TPR_2 repeat protein Anae109_3685 9 COG2013 COG2013, Uncharacterized conserved protein Function unknown 153004015 Common - adenylosuccinate lyase Anae109_1148 236 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 153004218 Nonpathogen - DoxX family protein Anae109_1352 3 None None None 153003793 Common - protein of unknown function DUF477 Anae109_0925 84 COG1512 COG1512, Beta-propeller domains of methanol dehydrogenase type General function prediction only 153004206 Common - diacylglycerol kinase catalytic region Anae109_1339 87 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 153006935 Common - transcriptional repressor, CopY family Anae109_4098 37 COG3682 COG3682, Predicted transcriptional regulator Transcription 153005849 Common - thiamine pyrophosphate protein domain protein TPP-binding Anae109_2993 113 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 153006285 Common - pseudouridine synthase, RluA family Anae109_3442 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 153007109 Nonpathogen - hypothetical protein Anae109_4272 1 None None None 153004181 Nonpathogen - hypothetical protein Anae109_1314 1 None None None 153006007 Common - hypothetical protein Anae109_3152 8 None None None 153006036 Common - protein of unknown function UPF0118 Anae109_3181 116 COG0628 PerM, Predicted permease General function prediction only 153005699 Common - hypothetical protein Anae109_2840 10 None None None 153005209 Nonpathogen - hypothetical protein Anae109_2348 1 None None None 153003603 Common - hypothetical protein Anae109_0731 11 COG3031 PulC, Type II secretory pathway, component PulC Intracellular trafficking and secretion 153005349 Nonpathogen - hypothetical protein Anae109_2489 1 None None None 153006350 Common - asparaginase Anae109_3508 86 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 153003294 Common - phosphate ABC transporter, inner membrane subunit PstA Anae109_0420 220 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 153003179 Common - uridylate kinase Anae109_0304 243 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 153003085 Common - 3-dehydroquinate synthase Anae109_0208 205 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 153006193 Common - protein kinase Anae109_3350 142 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153004369 Common - Asparaginase Anae109_1503 84 COG1446 COG1446, Asparaginase Amino acid transport and metabolism 153004262 Common - protein kinase Anae109_1396 141 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153006936 Nonpathogen - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_4099 5 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153002882 Common - DNA replication and repair protein RecF Anae109_0003 159 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 153003695 Common - NAD-dependent epimerase/dehydratase Anae109_0825 157 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153004143 Common - deoxyhypusine synthase Anae109_1276 63 COG1899 DYS1, Deoxyhypusine synthase Posttranslational modification, protein turnover, chaperones 153004830 Nonpathogen - hypothetical protein Anae109_1968 1 None None None 153004852 Common - molybdenum cofactor biosynthesis protein A Anae109_1990 200 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 153004465 Common - multicopper oxidase type 2 Anae109_1602 103 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 153004611 Common - peptidylprolyl isomerase FKBP-type Anae109_1749 157 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 153006584 Nonpathogen - hypothetical protein Anae109_3746 1 None None None 153004720 Nonpathogen - hypothetical protein Anae109_1858 1 None None None 153005119 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_2258 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153003295 Common - phosphate ABC transporter, ATPase subunit Anae109_0421 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 153004091 Common - hypothetical protein Anae109_1224 31 COG2836 COG2836, Uncharacterized conserved protein Function unknown 153005648 Nonpathogen - hypothetical protein Anae109_2789 1 None None None 153006389 Common - methylated-DNA--protein-cysteine methyltransferase Anae109_3549 221 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 153004531 Nonpathogen - hypothetical protein Anae109_1668 1 None None None 153004417 Nonpathogen - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_1553 3 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153006240 Nonpathogen - hypothetical protein Anae109_3397 1 None None None 153003987 Common - surface antigen (D15) Anae109_1120 160 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 153005380 Common - Methylenetetrahydrofolate dehydrogenase (NADP(+)) Anae109_2520 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 153006349 Nonpathogen - hypothetical protein Anae109_3507 1 None None None 153004959 Common - putative TetR family transcriptional regulator Anae109_2097 19 None None None 153003760 Common - secretion protein HlyD family protein Anae109_0892 109 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 153004134 Common - bifunctional deaminase-reductase domain protein Anae109_1267 46 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 153007257 Nonpathogen - hypothetical protein Anae109_4420 8 COG5426 COG5426, Uncharacterized membrane protein Function unknown 153003509 Common - aminotransferase class V Anae109_0637 239 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 153004968 Common - ABC-1 domain protein Anae109_2106 185 COG0661 AarF, Predicted unusual protein kinase General function prediction only 153004169 Common - PHP domain protein Anae109_1302 67 COG1796 POL4, DNA polymerase IV (family X) DNA replication, recombination, and repair 153004297 Nonpathogen - HNH endonuclease Anae109_1431 3 COG1403 McrA, Restriction endonuclease Defense mechanisms 153003444 Nonpathogen - CHAD domain containing protein Anae109_0571 2 COG5607 COG5607, Uncharacterized conserved protein Function unknown 153004920 Common - hypothetical protein Anae109_2058 20 COG3644 COG3644, Uncharacterized protein conserved in bacteria Function unknown 153004239 Common - cytochrome c assembly protein Anae109_1373 93 COG4137 COG4137, ABC-type uncharacterized transport system, permease component General function prediction only 153004792 Common - ribosomal protein L15 Anae109_1930 207 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 153006426 Nonpathogen - hypothetical protein Anae109_3586 5 None None None 153005221 Common - Thioredoxin domain Anae109_2360 223 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 153006001 Common - alkylhydroperoxidase like protein, AhpD family Anae109_3146 81 COG2128 COG2128, Uncharacterized conserved protein Function unknown 153006468 Common - oxidoreductase molybdopterin binding Anae109_3628 132 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 153005583 Nonpathogen - phosphoesterase PA-phosphatase related Anae109_2723 1 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 153005567 Common - hypothetical protein Anae109_2707 4 None None None 153005055 Common - phosphoribosyltransferase Anae109_2194 109 COG2065 PyrR, Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase Nucleotide transport and metabolism 153005743 Common - Endonuclease V Anae109_2884 16 COG1515 Nfi, Deoxyinosine 3'endonuclease (endonuclease V) DNA replication, recombination, and repair 153005494 Common - hypothetical protein Anae109_2634 16 COG2348 COG2348, Uncharacterized protein involved in methicillin resistance Defense mechanisms 153003658 Common - beta-lactamase domain protein Anae109_0787 24 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 153005002 Common - putative transcriptional regulator, MerR family Anae109_2141 120 COG0789 SoxR, Predicted transcriptional regulators Transcription 153004723 Common - hypothetical protein Anae109_1861 11 None None None 153003314 Common - TRAP dicarboxylate transporter- DctP subunit Anae109_0440 96 COG1638 DctP, TRAP-type C4-dicarboxylate transport system, periplasmic component Carbohydrate transport and metabolism 153004711 Nonpathogen - histidine kinase A domain protein Anae109_1849 2 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153005778 Common - protein of unknown function DUF224 cysteine-rich region domain protein Anae109_2919 162 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 153003352 Common - prolyl-tRNA synthetase Anae109_0478 244 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153004963 Nonpathogen - hypothetical protein Anae109_2101 2 None None None 153003865 Common - Holliday junction DNA helicase RuvB Anae109_0997 225 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 153006434 Nonpathogen - hypothetical protein Anae109_3594 2 None None None 153003754 Nonpathogen - hypothetical protein Anae109_0886 1 None None None 153006006 Nonpathogen - ribosomal L11 methyltransferase Anae109_3151 2 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 153005818 Common - protein of unknown function DUF214 Anae109_2960 28 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 153004052 Common - H+transporting two-sector ATPase alpha/beta subunit central region Anae109_1185 200 COG1158 Rho, Transcription termination factor Transcription 153006577 Common - Uracil-DNA glycosylase superfamily Anae109_3739 28 COG3663 Mug, G:T/U mismatch-specific DNA glycosylase DNA replication, recombination, and repair 153005879 Nonpathogen - methyltransferase type 12 Anae109_3023 5 None None None 153005973 Nonpathogen - hypothetical protein Anae109_3118 1 None None None 153006421 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_3581 223 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153005969 Common - protein kinase Anae109_3114 147 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153005408 Common - protein of unknown function DUF1355 Anae109_2548 41 COG5426 COG5426, Uncharacterized membrane protein Function unknown 153007036 Common - glycosyl transferase family 39 Anae109_4199 15 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 153007189 Common - histone family protein DNA-binding protein Anae109_4352 192 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 153005641 Common - protein of unknown function DUF6 transmembrane Anae109_2782 81 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 153004708 Common - histidine kinase Anae109_1846 221 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153003743 Nonpathogen - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_0875 3 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153003862 Common - HNH nuclease Anae109_0994 3 None None None 153003331 Common - protein of unknown function DUF179 Anae109_0457 123 COG1678 COG1678, Putative transcriptional regulator Transcription 153003374 Common - Bilirubin oxidase Anae109_0501 68 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 153006308 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Anae109_3465 30 COG3871 COG3871, Uncharacterized stress protein (general stress protein 26) General function prediction only 153004024 Common - OmpA/MotB domain protein Anae109_1157 173 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 153003629 Common - imidazoleglycerol phosphate synthase, cyclase subunit Anae109_0757 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 153004609 Nonpathogen - hypothetical protein Anae109_1747 1 None None None 153007054 Nonpathogen - hypothetical protein Anae109_4217 3 COG3809 COG3809, Uncharacterized protein conserved in bacteria Function unknown 153007141 Nonpathogen - hypothetical protein Anae109_4304 1 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 153003493 Nonpathogen - hypothetical protein Anae109_0621 1 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 153003138 Nonpathogen - hypothetical protein Anae109_0261 2 None None None 153003552 Nonpathogen - fimbrial protein pilin Anae109_0680 1 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 153007006 Common - ribonuclease Z Anae109_4169 102 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 153006400 Nonpathogen - hypothetical protein Anae109_3560 1 None None None 153004311 Common - molybdenum cofactor synthesis domain Anae109_1445 194 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 153003330 Common - recA protein Anae109_0456 220 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 153005118 Common - response regulator receiver modulated diguanylate cyclase Anae109_2257 224 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153004871 Common - formate dehydrogenase, beta subunit Anae109_2009 160 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153006654 Nonpathogen - diacylglycerol kinase catalytic region Anae109_3816 3 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 153005017 Common - GTP-binding protein Era Anae109_2156 225 COG1159 Era, GTPase General function prediction only 153005954 Common - acetate kinase Anae109_3099 162 COG0282 ackA, Acetate kinase Energy production and conversion 153005684 Nonpathogen - hypothetical protein Anae109_2825 1 None None None 153006838 Common - hypothetical protein Anae109_4001 9 None None None 153004221 Common - Hemerythrin HHE cation binding domain protein Anae109_1355 10 COG2846 COG2846, Regulator of cell morphogenesis and NO signaling Cell division and chromosome partitioning 153003233 Common - Glutathione S-transferase domain Anae109_0359 93 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 153004109 Nonpathogen - hypothetical protein Anae109_1242 1 None None None 153005043 Common - Nucleoside-diphosphate kinase Anae109_2182 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 153004663 Common - Polysulphide reductase NrfD Anae109_1801 30 COG5557 COG5557, Polysulphide reductase Energy production and conversion 153004497 Common - hypothetical protein Anae109_1634 15 None None None 153006823 Nonpathogen - hypothetical protein Anae109_3986 2 None None None 153003030 Common - PTS system fructose subfamily IIA component Anae109_0153 97 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 153003248 Common - anthranilate phosphoribosyltransferase Anae109_0374 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 153005993 Common - membrane protein-like protein Anae109_3138 52 COG4327 COG4327, Predicted membrane protein Function unknown 153007288 Common - peptidase S16 lon domain protein Anae109_4451 43 COG2802 COG2802, Uncharacterized protein, similar to the N-terminal domain of Lon protease General function prediction only 153007091 Nonpathogen - protein of unknown function DUF456 Anae109_4254 1 COG2839 COG2839, Uncharacterized protein conserved in bacteria Function unknown 153003158 Common - methylmalonyl-CoA mutase, large subunit Anae109_0281 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 153006129 Nonpathogen - hypothetical protein Anae109_3281 1 None None None 153004323 Common - Smr protein/MutS2 Anae109_1457 204 COG1193 COG1193, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 153005850 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Anae109_2994 111 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 153003418 Common - cytochrome oxidase assembly Anae109_0545 17 COG1612 CtaA, Uncharacterized protein required for cytochrome oxidase assembly Posttranslational modification, protein turnover, chaperones 153005961 Nonpathogen - translation initiation factor 2 Anae109_3106 1 COG4907 COG4907, Predicted membrane protein Function unknown 153002986 Nonpathogen - GCN5-related N-acetyltransferase Anae109_0109 2 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 153004419 Common - putative transmembrane anti-sigma factor Anae109_1555 3 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 153007190 Common - hypothetical protein Anae109_4353 12 None None None 153006117 Common - transcriptional regulator, BadM/Rrf2 family Anae109_3265 58 COG1959 COG1959, Predicted transcriptional regulator Transcription 153003831 Common - hypothetical protein Anae109_0963 8 None None None 153006075 Nonpathogen - hypothetical protein Anae109_3221 10 COG4641 COG4641, Uncharacterized protein conserved in bacteria Function unknown 153006851 Nonpathogen - hypothetical protein Anae109_4014 2 None None None 153004860 Common - dihydrolipoamide dehydrogenase Anae109_1998 244 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 153005113 Nonpathogen - HEAT domain containing protein Anae109_2252 1 None None None 153006317 Common - transglutaminase domain protein Anae109_3474 40 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 153003287 Common - diguanylate cyclase Anae109_0413 175 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153003263 Common - dihydrodipicolinate reductase Anae109_0389 17 COG3804 COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase Function unknown 153006496 Common - transcriptional regulator, LysR family Anae109_3657 189 COG0583 LysR, Transcriptional regulator Transcription 153003702 Common - DNA ligase D Anae109_0832 108 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 153005890 Common - ADP-ribosyl-(dinitrogen reductase) hydrolase Anae109_3034 51 COG1397 DraG, ADP-ribosylglycohydrolase Posttranslational modification, protein turnover, chaperones 153006090 Nonpathogen - hypothetical protein Anae109_3237 2 None None None 153005664 Common - regulatory protein ArsR Anae109_2805 60 COG0640 ArsR, Predicted transcriptional regulators Transcription 153003465 Common - putative oxidoreductase Anae109_0592 69 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153005736 Common - 3-hydroxyacyl-CoA dehydrogenase NAD-binding Anae109_2877 158 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 153003648 Common - Protein phosphatase 2C-like protein Anae109_0777 134 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 153004386 Common - cyclic nucleotide-binding protein Anae109_1521 7 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 153006373 Common - CheA signal transduction histidine kinase Anae109_3533 208 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 153005289 Common - transcriptional regulator, NifA subfamily, Fis Family Anae109_2429 171 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 153005358 Common - transcriptional regulator, CarD family Anae109_2498 85 COG1329 COG1329, Transcriptional regulators, similar to M. xanthus CarD Transcription 153006041 Common - Lipocalin family protein Anae109_3186 74 COG3040 Blc, Bacterial lipocalin Cell envelope biogenesis, outer membrane 153006050 Common - hypothetical protein Anae109_3195 83 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 153006391 Nonpathogen - protein of unknown function UPF0153 Anae109_3551 4 None None None 153003855 Nonpathogen - protein of unknown function DUF101 Anae109_0987 1 COG1371 COG1371, Uncharacterized conserved protein Function unknown 153005365 Common - Histidine--tRNA ligase Anae109_2505 116 COG3705 HisZ, ATP phosphoribosyltransferase involved in histidine biosynthesis Amino acid transport and metabolism 153007064 Nonpathogen - hypothetical protein Anae109_4227 3 None None None 153003096 Nonpathogen - hypothetical protein Anae109_0219 1 None None None 153005106 Nonpathogen - hypothetical protein Anae109_2245 1 None None None 153003408 Common - fimbrial biogenesis outer membrane usher protein Anae109_0535 32 COG3188 FimD, P pilus assembly protein, porin PapC Cell motility and secretion / Intracellular trafficking and secretion 153003023 Nonpathogen - PE-PGRS family protein Anae109_0146 1 COG3846 TrbL, Type IV secretory pathway, TrbL components Intracellular trafficking and secretion 153005461 Common - conserved hypothetical protein 730 Anae109_2601 116 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 153004884 Common - 2-alkenal reductase Anae109_2022 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 153003719 Common - Cytochrome c oxidase subunit I type Anae109_0849 164 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 153004993 Common - hypothetical protein Anae109_2131 3 None None None 153006959 Common - ribose-phosphate pyrophosphokinase Anae109_4122 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 153004829 Common - Methyltransferase type 11 Anae109_1967 69 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153004758 Common - pyruvate ferredoxin/flavodoxin oxidoreductase Anae109_1896 62 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 153004867 Common - PAS/PAC sensor hybrid histidine kinase Anae109_2005 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153005436 Common - glycosyl transferase group 1 Anae109_2576 113 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153003856 Common - MATE efflux family protein Anae109_0988 119 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 153003253 Common - glycosyl transferase group 1 Anae109_0379 44 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153007227 Common - ATP-dependent metalloprotease FtsH Anae109_4390 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 153006885 Common - urease, gamma subunit Anae109_4048 96 COG0831 UreA, Urea amidohydrolase (urease) gamma subunit Amino acid transport and metabolism 153007177 Common - hypothetical protein Anae109_4340 6 COG3809 COG3809, Uncharacterized protein conserved in bacteria Function unknown 153003154 Nonpathogen - hypothetical protein Anae109_0277 1 None None None 153003005 Nonpathogen - hypothetical protein Anae109_0128 1 None None None 153003335 Common - 2'-5' RNA ligase Anae109_0461 101 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 153006409 Common - periplasmic binding protein Anae109_3569 45 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 153003925 Common - Epoxide hydrolase domain protein Anae109_1058 39 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153005444 Common - ABC transporter related Anae109_2584 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 153006461 Nonpathogen - putative transmembrane anti-sigma factor Anae109_3621 4 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 153005191 Common - protein of unknown function UPF0079 Anae109_2330 194 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 153006386 Common - AAA ATPase central domain protein Anae109_3546 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 153007015 Nonpathogen - hypothetical protein Anae109_4178 5 None None None 153006545 Common - protein kinase Anae109_3707 148 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153007165 Common - ribosomal protein L21 Anae109_4328 202 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 153006681 Nonpathogen - hypothetical protein Anae109_3843 1 None None None 153004309 Common - Fe(II) trafficking protein YggX Anae109_1443 72 COG2924 COG2924, Uncharacterized protein conserved in bacteria Function unknown 153006088 Common - sulfatase Anae109_3235 64 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 153006369 Nonpathogen - hypothetical protein Anae109_3529 1 None None None 153006150 Common - Non-specific serine/threonine protein kinase Anae109_3304 168 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 153006519 Nonpathogen - hypothetical protein Anae109_3680 1 None None None 153002996 Common - protein kinase Anae109_0119 147 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153003055 Nonpathogen - hypothetical protein Anae109_0178 7 None None None 153003224 Nonpathogen - hypothetical protein Anae109_0350 3 None None None 153003932 Common - regulatory protein ArsR Anae109_1065 96 COG1777 COG1777, Predicted transcriptional regulators Transcription 153005231 Common - Protein-glutamate O-methyltransferase Anae109_2370 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 153004120 Common - hypothetical protein Anae109_1253 5 None None None 153004854 Common - lipoic acid synthetase Anae109_1992 190 COG0320 LipA, Lipoate synthase Coenzyme metabolism 153004891 Common - response regulator receiver protein Anae109_2029 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153003596 Common - hypothetical protein Anae109_0724 8 COG4795 PulJ, Type II secretory pathway, component PulJ Intracellular trafficking and secretion 153004300 Nonpathogen - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_1434 9 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153004730 Common - hypothetical protein Anae109_1868 6 None None None 153006470 Common - protein of unknown function DUF417 Anae109_3630 17 COG3059 COG3059, Predicted membrane protein Function unknown 153006809 Nonpathogen - Flp/Fap pilin component Anae109_3972 1 COG3847 Flp, Flp pilus assembly protein, pilin Flp Intracellular trafficking and secretion 153004802 Common - phosphoesterase PA-phosphatase related Anae109_1940 5 None None None 153003362 Common - Alcohol dehydrogenase zinc-binding domain protein Anae109_0488 195 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 153003768 Common - ATP-dependent DNA helicase, RecQ family Anae109_0900 236 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 153005254 Common - homocitrate synthase Anae109_2393 212 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 153002947 Common - Radical SAM domain protein Anae109_0068 73 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 153007309 Common - ABC branched chain amino acid transporter, periplasmic ligand binding protein Anae109_4472 20 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 153005238 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Anae109_2377 1 None None None 153006849 Nonpathogen - LigA Anae109_4012 1 None None None 153005228 Common - CheA signal transduction histidine kinase Anae109_2367 187 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 153004151 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_1284 190 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 153007250 Common - ABC transporter related Anae109_4413 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 153005862 Common - NAD-dependent epimerase/dehydratase Anae109_3006 50 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153006765 Common - Methyltransferase type 11 Anae109_3927 74 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153005658 Nonpathogen - hypothetical protein Anae109_2799 1 None None None 153006688 Nonpathogen - HNH endonuclease Anae109_3850 3 COG1403 McrA, Restriction endonuclease Defense mechanisms 153004791 Common - ribosomal protein L30 Anae109_1929 37 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 153005756 Nonpathogen - electron transfer flavoprotein beta subunit-like protein Anae109_2897 2 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 153007170 Common - K channel inward rectifier conserved region 2 domain protein Anae109_4333 18 None None None 153007276 Nonpathogen - hypothetical protein Anae109_4439 1 None None None 153004441 Nonpathogen - hypothetical protein Anae109_1578 3 None None None 153006677 Common - NADH:flavin oxidoreductase/NADH oxidase Anae109_3839 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 153003219 Nonpathogen - hypothetical protein Anae109_0345 1 None None None 153004977 Nonpathogen - hypothetical protein Anae109_2115 3 None None None 153005296 Common - UspA domain protein Anae109_2436 62 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 153006100 Common - DNA polymerase LigD polymerase domain Anae109_3248 66 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 153004679 Common - hypothetical protein Anae109_1817 4 None None None 153004631 Nonpathogen - hypothetical protein Anae109_1769 1 None None None 153004317 Common - ABC transporter related Anae109_1451 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 153005455 Nonpathogen - hypothetical protein Anae109_2595 22 None None None 153005594 Common - ribose 5-phosphate isomerase B Anae109_2734 127 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 153005178 Common - phosphodiesterase, MJ0936 family Anae109_2317 77 COG0622 COG0622, Predicted phosphoesterase General function prediction only 153003724 Common - Glutamate synthase (ferredoxin) Anae109_0854 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 153004348 Nonpathogen - hypothetical protein Anae109_1482 7 None None None 153006787 Common - major facilitator superfamily MFS_1 Anae109_3950 76 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 153007118 Nonpathogen - hypothetical protein Anae109_4281 1 None None None 153003324 Nonpathogen - HNH endonuclease Anae109_0450 4 COG1403 McrA, Restriction endonuclease Defense mechanisms 153004291 Common - glycosyl transferase group 1 Anae109_1425 202 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153005181 Common - putative mucoidy inhibitor A Anae109_2320 24 None None None 153003111 Nonpathogen - hypothetical protein Anae109_0234 1 None None None 153007331 Common - ATP synthase F1, epsilon subunit Anae109_4494 180 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 153005279 Common - acyl-CoA dehydrogenase domain protein Anae109_2419 167 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 153005188 Common - cell surface receptor IPT/TIG domain protein Anae109_2327 42 COG5276 COG5276, Uncharacterized conserved protein Function unknown 153005631 Common - peptidase M48 Ste24p Anae109_2772 189 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 153005009 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Anae109_2148 215 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 153005904 Nonpathogen - UspA domain protein Anae109_3048 1 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 153005693 Common - hypothetical protein Anae109_2834 57 COG3214 COG3214, Uncharacterized protein conserved in bacteria Function unknown 153005125 Common - 2-alkenal reductase Anae109_2264 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 153004480 Common - ABC transporter related Anae109_1617 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 153006483 Common - regulatory protein ArsR Anae109_3644 65 COG0640 ArsR, Predicted transcriptional regulators Transcription 153003070 Common - Methyltransferase type 12 Anae109_0193 20 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 153005947 Common - Endonuclease/exonuclease/phosphatase Anae109_3092 7 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 153005622 Nonpathogen - cytochrome C family protein Anae109_2763 2 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 153007323 Common - ATP synthase F0, C subunit Anae109_4486 12 None None None 153005198 Common - dihydropteroate synthase Anae109_2337 213 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 153003838 Common - protein of unknown function UPF0047 Anae109_0970 140 COG0432 COG0432, Uncharacterized conserved protein Function unknown 153006338 Common - DEAD/DEAH box helicase domain protein Anae109_3496 227 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 153006143 Nonpathogen - hypothetical protein Anae109_3295 1 None None None 153005689 Common - DNA primase small subunit Anae109_2830 66 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 153005867 Common - HAD-superfamily hydrolase, subfamily IIB Anae109_3011 99 COG0380 OtsA, Trehalose-6-phosphate synthase Carbohydrate transport and metabolism 153005031 Common - cyclase/dehydrase Anae109_2170 4 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 153006360 Common - nickel-dependent hydrogenase large subunit Anae109_3520 94 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 153004551 Common - hypothetical protein Anae109_1688 8 COG2974 RdgC, DNA recombination-dependent growth factor C DNA replication, recombination, and repair 153006805 Common - type II and III secretion system protein Anae109_3968 136 COG4964 CpaC, Flp pilus assembly protein, secretin CpaC Intracellular trafficking and secretion 153003812 Nonpathogen - protein of unknown function DUF420 Anae109_0944 7 COG2322 COG2322, Predicted membrane protein Function unknown 153006738 Nonpathogen - hypothetical protein Anae109_3900 1 None None None 153005909 Nonpathogen - hypothetical protein Anae109_3053 1 None None None 153005984 Common - hypothetical protein Anae109_3129 9 COG5368 COG5368, Uncharacterized protein conserved in bacteria Function unknown 153005771 Nonpathogen - PfkB domain protein Anae109_2912 3 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 153004100 Nonpathogen - Ig domain protein group 2 domain protein Anae109_1233 5 None None None 153005153 Common - Citrate transporter Anae109_2292 95 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 153006759 Nonpathogen - hypothetical protein Anae109_3921 1 None None None 153004125 Common - fumarate lyase Anae109_1258 202 COG0114 FumC, Fumarase Energy production and conversion 153006623 Common - NADH-ubiquinone oxidoreductase chain 49kDa Anae109_3785 192 COG3261 HycE, Ni,Fe-hydrogenase III large subunit Energy production and conversion 153007206 Common - Smr protein/MutS2 Anae109_4369 61 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 153004310 Common - helix-turn-helix domain protein Anae109_1444 40 COG1813 COG1813, Predicted transcription factor, homolog of eukaryotic MBF1 Transcription 153005185 Common - YD repeat protein Anae109_2324 66 COG3209 RhsA, Rhs family protein Cell envelope biogenesis, outer membrane 153003772 Common - FeS assembly ATPase SufC Anae109_0904 248 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 153002928 Common - Electron transfer flavoprotein alpha/beta-subunit Anae109_0049 152 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 153006163 Common - protein of unknown function DUF114 Anae109_3319 41 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 153003510 Common - FeS cluster assembly scaffold IscU Anae109_0638 152 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 153007344 Common - protein of unknown function DUF37 Anae109_4507 186 COG0759 COG0759, Uncharacterized conserved protein Function unknown 153005919 Common - YbaK/prolyl-tRNA synthetase associated region Anae109_3064 27 COG2606 EbsC, Uncharacterized conserved protein Function unknown 153003806 Common - Ku family containing protein Anae109_0938 63 COG1273 COG1273, Uncharacterized conserved protein Function unknown 153005143 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Anae109_2282 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 153003203 Common - protein kinase Anae109_0329 152 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153004426 Common - transcriptional regulator, Fis family Anae109_1563 168 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 153006909 Nonpathogen - hypothetical protein Anae109_4072 1 None None None 153003243 Nonpathogen - hypothetical protein Anae109_0369 2 None None None 153006501 Common - Activator of Hsp90 ATPase 1 family protein Anae109_3662 7 COG3832 COG3832, Uncharacterized conserved protein Function unknown 153006751 Common - Glutamate--cysteine ligase Anae109_3913 53 COG3572 GshA, Gamma-glutamylcysteine synthetase Coenzyme metabolism 153005785 Nonpathogen - hypothetical protein Anae109_2926 1 None None None 153005012 Nonpathogen - hypothetical protein Anae109_2151 1 None None None 153005272 Nonpathogen - hypothetical protein Anae109_2412 3 None None None 153004915 Common - phosphoserine phosphatase/homoserine phosphotransferase bifunctional protein Anae109_2053 23 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 153004744 Common - ribosomal protein L20 Anae109_1882 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 153005164 Common - ABC transporter related Anae109_2303 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 153006723 Common - UDP-N-acetylmuramate--alanine ligase Anae109_3885 208 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 153003073 Common - D-tyrosyl-tRNA(Tyr) deacylase Anae109_0196 139 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 153003541 Common - type II secretion system protein Anae109_0669 145 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 153004760 Nonpathogen - putative lipoprotein Anae109_1898 4 None None None 153004804 Common - hypothetical protein Anae109_1942 67 COG1837 COG1837, Predicted RNA-binding protein (contains KH domain) General function prediction only 153005038 Nonpathogen - Pyrrolo-quinoline quinone Anae109_2177 2 COG1520 COG1520, FOG: WD40-like repeat Function unknown 153006083 Common - Non-specific serine/threonine protein kinase Anae109_3229 110 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 153003315 Nonpathogen - hypothetical protein Anae109_0441 1 None None None 153005791 Nonpathogen - 4-oxalocrotonate tautomerase Anae109_2932 2 None None None 153006729 Common - Bilirubin oxidase Anae109_3891 66 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 153006883 Common - phospholipase D/Transphosphatidylase Anae109_4046 154 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 153003461 Common - methyl-accepting chemotaxis sensory transducer Anae109_0588 140 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153004012 Common - ribosomal protein S15 Anae109_1145 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 153005155 Common - Protein-glutamate O-methyltransferase Anae109_2294 150 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 153006500 Common - transcriptional regulator, TetR family Anae109_3661 4 COG1309 AcrR, Transcriptional regulator Transcription 153006757 Common - exsB protein Anae109_3919 175 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 153005312 Common - histidine kinase Anae109_2452 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153005864 Common - protein of unknown function DUF523 Anae109_3008 77 COG3272 COG3272, Uncharacterized conserved protein Function unknown 153005204 Nonpathogen - hypothetical protein Anae109_2343 3 None None None 153004095 Common - hypothetical protein Anae109_1228 6 None None None 153005163 Common - hydroxymethylbutenyl pyrophosphate reductase Anae109_2302 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 153002921 Common - pyruvate ferredoxin/flavodoxin oxidoreductase Anae109_0042 70 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 153007163 Common - GTP-binding protein Obg/CgtA Anae109_4326 249 COG0536 Obg, Predicted GTPase General function prediction only 153004714 Nonpathogen - hypothetical protein Anae109_1852 3 None None None 153005780 Common - D-lactate dehydrogenase (cytochrome) Anae109_2921 201 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 153005115 Nonpathogen - hypothetical protein Anae109_2254 1 None None None 153005541 Common - hypothetical protein Anae109_2681 6 None None None 153006079 Nonpathogen - glycoside hydrolase family 5 Anae109_3225 3 COG2730 BglC, Endoglucanase Carbohydrate transport and metabolism 153004484 Nonpathogen - hypothetical protein Anae109_1621 5 None None None 153005434 Common - domain of unknown function DUF1732 Anae109_2574 137 COG1561 COG1561, Uncharacterized stress-induced protein Function unknown 153006802 Common - type II secretion system protein Anae109_3965 83 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 153006879 Common - putative cold-shock DNA-binding domain protein Anae109_4042 183 COG1278 CspC, Cold shock proteins Transcription 153006132 Common - helix-turn-helix- domain containing protein AraC type Anae109_3284 114 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 153005535 Common - dephospho-CoA kinase Anae109_2675 192 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 153003726 Common - protein of unknown function DUF6 transmembrane Anae109_0856 24 None None None 153003361 Nonpathogen - hypothetical protein Anae109_0487 1 None None None 153006788 Nonpathogen - hypothetical protein Anae109_3951 1 None None None 153006981 Common - MJ0042 family finger-like protein Anae109_4144 43 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153007205 Nonpathogen - phosphoesterase PA-phosphatase related Anae109_4368 3 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 153005679 Common - hypothetical protein Anae109_2820 14 COG3189 COG3189, Uncharacterized conserved protein Function unknown 153003266 Nonpathogen - hypothetical protein Anae109_0392 1 None None None 153006618 Common - NADH dehydrogenase (quinone) Anae109_3780 191 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 153006870 Common - sodium/hydrogen exchanger Anae109_4033 36 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 153006405 Common - DNA repair protein RadA Anae109_3565 201 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 153007162 Common - tRNA/rRNA methyltransferase (SpoU) Anae109_4325 124 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 153004971 Nonpathogen - cytochrome c, class III Anae109_2109 3 None None None 153006546 Nonpathogen - hypothetical protein Anae109_3708 2 None None None 153005442 Common - Three-deoxy-D-manno-octulosonic-acid transferase domain protein Anae109_2582 128 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 153004427 Common - aldo/keto reductase Anae109_1564 202 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 153003298 Nonpathogen - lipoprotein, putative Anae109_0424 1 None None None 153007119 Common - Linocin_M18 bacteriocin protein Anae109_4282 19 COG1659 COG1659, Uncharacterized protein, linocin/CFP29 homolog Function unknown 153005885 Common - nitrogenase molybdenum-iron protein alpha chain Anae109_3029 54 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 153007050 Common - peptide chain release factor 1 Anae109_4213 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 153004813 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_1951 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153006262 Common - aminotransferase class V Anae109_3419 198 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 153002953 Nonpathogen - hypothetical protein Anae109_0074 2 None None None 153005206 Common - protein of unknown function DUF849 Anae109_2345 62 COG3246 COG3246, Uncharacterized conserved protein Function unknown 153007084 Nonpathogen - Collagen triple helix repeat Anae109_4247 1 None None None 153003871 Common - cyclase/dehydrase Anae109_1003 36 COG5637 COG5637, Predicted integral membrane protein Function unknown 153005980 Common - protein kinase Anae109_3125 149 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153005765 Nonpathogen - type IV pilus assembly PilZ Anae109_2906 1 COG3393 COG3393, Predicted acetyltransferase General function prediction only 153006109 Common - protein of unknown function DUF1568 Anae109_3257 24 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 153007112 Common - putative lipoprotein Anae109_4275 12 None None None 153007343 Common - 60 kDa inner membrane insertion protein Anae109_4506 208 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 153004576 Common - cytochrome c assembly protein Anae109_1713 101 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 153007061 Common - hypothetical protein Anae109_4224 3 COG3886 COG3886, Predicted HKD family nuclease DNA replication, recombination, and repair 153004130 Common - glutaminyl-tRNA synthetase Anae109_1263 248 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 153005500 Nonpathogen - hypothetical protein Anae109_2640 2 None None None 153004089 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_1222 76 COG0348 NapH, Polyferredoxin Energy production and conversion 153006920 Common - Radical SAM domain protein Anae109_4083 54 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 153005873 Common - PAS/PAC sensor hybrid histidine kinase Anae109_3017 200 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153006616 Nonpathogen - hypothetical protein Anae109_3778 1 None None None 153006722 Common - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Anae109_3884 208 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 153006638 Nonpathogen - hypothetical protein Anae109_3800 1 None None None 153003378 Common - DNA-formamidopyrimidine glycosylase Anae109_0505 169 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 153002949 Common - adenosylmethionine-8-amino-7-oxononanoate aminotransferase Anae109_0070 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 153003430 Nonpathogen - hypothetical protein Anae109_0557 1 None None None 153003033 Common - PTS system mannose/fructose/sorbose family IID component Anae109_0156 40 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 153007094 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_4257 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153005966 Nonpathogen - hypothetical protein Anae109_3111 1 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 153006834 Common - HhH-GPD family protein Anae109_3997 12 COG1059 COG1059, Thermostable 8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 153007338 Common - parB-like partition protein Anae109_4501 183 COG1475 Spo0J, Predicted transcriptional regulators Transcription 153006024 Common - methylmalonyl-CoA mutase, large subunit Anae109_3169 110 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 153005045 Common - succinyl-CoA synthetase, beta subunit Anae109_2184 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 153006987 Common - selenocysteine-specific translation elongation factor Anae109_4150 249 COG3276 SelB, Selenocysteine-specific translation elongation factor Translation, ribosomal structure and biogenesis 153006745 Common - tRNA (guanine-N(7)-)-methyltransferase Anae109_3907 13 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 153004732 Common - histidine kinase Anae109_1870 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153005416 Common - AraC-type transcriptional regulator domain protein Anae109_2556 69 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 153006517 Common - transposase IS66 Anae109_3678 65 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 153006691 Common - multi-sensor signal transduction histidine kinase Anae109_3853 221 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 153006672 Common - hypothetical protein Anae109_3834 27 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 153003190 Common - transketolase Anae109_0315 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 153004212 Common - thiamine biosynthesis protein ThiS Anae109_1345 59 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 153005805 Common - oligopeptide transporter, OPT superfamily Anae109_2947 16 COG1297 COG1297, Predicted membrane protein Function unknown 153004477 Common - CBS domain containing protein Anae109_1614 69 COG1993 COG1993, Uncharacterized conserved protein Function unknown 153006657 Common - putative GAF sensor protein Anae109_3819 83 COG1956 COG1956, GAF domain-containing protein Signal transduction mechanisms 153004966 Common - SOS-response transcriptional repressor, LexA Anae109_2104 173 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 153006416 Common - ABC transporter related Anae109_3576 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 153003213 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_0339 31 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 153003282 Nonpathogen - hypothetical protein Anae109_0408 1 None None None 153005810 Nonpathogen - hypothetical protein Anae109_2952 3 None None None 153006063 Nonpathogen - hypothetical protein Anae109_3209 1 None None None 153003580 Common - glutamate racemase Anae109_0708 189 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 153003721 Common - caa(3)-type oxidase, subunit IV Anae109_0851 8 COG5605 COG5605, Predicted small integral membrane protein Function unknown 153006149 Nonpathogen - transcriptional regulator protein-like protein Anae109_3303 7 COG5340 COG5340, Predicted transcriptional regulator Transcription 153003218 Common - HNH endonuclease Anae109_0344 5 COG1403 McrA, Restriction endonuclease Defense mechanisms 153004508 Nonpathogen - bacterio-opsin linked product Anae109_1645 7 None None None 153006479 Common - transcriptional regulator, LysR family Anae109_3640 170 COG0583 LysR, Transcriptional regulator Transcription 153006358 Common - alpha/beta hydrolase fold Anae109_3518 30 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153005141 Common - Triose-phosphate isomerase Anae109_2280 217 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 153003371 Common - hypothetical protein Anae109_0498 6 None None None 153003200 Common - protein of unknown function DUF606 Anae109_0326 13 COG3238 COG3238, Uncharacterized protein conserved in bacteria Function unknown 153004316 Common - CBS domain containing protein Anae109_1450 141 COG0517 COG0517, FOG: CBS domain General function prediction only 153004733 Nonpathogen - hypothetical protein Anae109_1871 2 None None None 153004504 Common - sulfate ABC transporter, inner membrane subunit CysT Anae109_1641 223 COG0555 CysU, ABC-type sulfate transport system, permease component Posttranslational modification, protein turnover, chaperones 153003854 Common - protein of unknown function UPF0027 Anae109_0986 116 COG1690 RtcB, Uncharacterized conserved protein Function unknown 153007028 Common - tRNA pseudouridine synthase A Anae109_4191 233 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 153003412 Common - multi-sensor hybrid histidine kinase Anae109_0539 223 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 153006332 Nonpathogen - hypothetical protein Anae109_3490 1 None None None 153007315 Common - transcription-repair coupling factor Anae109_4478 217 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 153004682 Nonpathogen - hypothetical protein Anae109_1820 1 None None None 153005998 Common - putative CBS domain and cyclic nucleotide-regulated nucleotidyltransferase Anae109_3143 91 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 153004187 Nonpathogen - type IV pilus assembly PilZ Anae109_1320 1 COG3215 PilZ, Tfp pilus assembly protein PilZ Cell motility and secretion / Intracellular trafficking and secretion 153006444 Common - nitrite/sulfite reductase hemoprotein beta-component ferrodoxin domain protein Anae109_3604 152 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 153005133 Common - adenylylsulfate kinase Anae109_2272 143 COG0529 CysC, Adenylylsulfate kinase and related kinases Inorganic ion transport and metabolism 153006157 Common - cyclic nucleotide-regulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase Anae109_3313 246 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 153003101 Nonpathogen - Lysine exporter protein (LYSE/YGGA) Anae109_0224 3 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 153003916 Nonpathogen - hypothetical protein Anae109_1048 2 None None None 153005020 Common - Ribonuclease III Anae109_2159 215 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 153006960 Nonpathogen - regulatory protein LuxR Anae109_4123 1 COG2771 CsgD, DNA-binding HTH domain-containing proteins Transcription 153003505 Common - N-acetyl-gamma-glutamyl-phosphate reductase Anae109_0633 215 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 153003706 Common - ATP-dependent Clp protease adaptor protein ClpS Anae109_0836 119 COG2127 COG2127, Uncharacterized conserved protein Function unknown 153004990 Common - RNA-3'-phosphate cyclase Anae109_2128 47 COG0430 RCL1, RNA 3'-terminal phosphate cyclase RNA processing and modification 153003319 Common - rare lipoprotein A Anae109_0445 135 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 153004545 Common - hypothetical protein Anae109_1682 4 None None None 153005577 Nonpathogen - ribosomal protein S20 Anae109_2717 1 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 153007304 Common - MglA protein Anae109_4467 21 COG2229 COG2229, Predicted GTPase General function prediction only 153003810 Common - Tetratricopeptide TPR_4 Anae109_0942 12 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 153006002 Nonpathogen - hypothetical protein Anae109_3147 1 None None None 153006378 Common - periplasmic binding protein-related protein Anae109_3538 25 COG3221 PhnD, ABC-type phosphate/phosphonate transport system, periplasmic component Inorganic ion transport and metabolism 153007020 Common - AMP-dependent synthetase and ligase Anae109_4183 202 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153006089 Common - sulphate transporter Anae109_3236 159 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 153006590 Common - Helix-turn-helix type 11 domain protein Anae109_3752 26 COG2378 COG2378, Predicted transcriptional regulator Transcription 153006806 Common - SAF domain protein Anae109_3969 38 COG3745 CpaB, Flp pilus assembly protein CpaB Intracellular trafficking and secretion 153006687 Common - beta-lactamase domain protein Anae109_3849 51 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 153007047 Common - regulatory protein, ArsR Anae109_4210 34 COG1510 COG1510, Predicted transcriptional regulators Transcription 153005686 Common - hypothetical protein Anae109_2827 54 COG2323 COG2323, Predicted membrane protein Function unknown 153003108 Nonpathogen - hypothetical protein Anae109_0231 1 None None None 153006384 Nonpathogen - hypothetical protein Anae109_3544 9 None None None 153005212 Common - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Anae109_2351 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 153006056 Common - hypothetical protein Anae109_3201 19 COG3823 COG3823, Glutamine cyclotransferase Posttranslational modification, protein turnover, chaperones 153003237 Common - KpsF/GutQ family protein Anae109_0363 197 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 153004763 Common - NAD-dependent epimerase/dehydratase Anae109_1901 232 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153005127 Common - ATP-dependent Clp protease, ATP-binding subunit ClpX Anae109_2266 227 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 153003401 Common - MutT/NUDIX family protein Anae109_0528 13 None None None 153003226 Common - argininosuccinate lyase Anae109_0352 223 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 153006236 Nonpathogen - putative vgr-related protein Anae109_3393 4 None None None 153005578 Nonpathogen - hypothetical protein Anae109_2718 1 None None None 153005725 Common - SSS sodium solute transporter superfamily Anae109_2866 173 COG4147 DhlC, Predicted symporter General function prediction only 153003832 Common - Nitrite reductase (cytochrome; ammonia-forming) Anae109_0964 40 COG3303 NrfA, Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit Inorganic ion transport and metabolism 153004406 Common - Recombinase Anae109_1541 42 None None None 153003593 Nonpathogen - hypothetical protein Anae109_0721 2 None None None 153004632 Nonpathogen - hypothetical protein Anae109_1770 1 None None None 153006381 Nonpathogen - LigA Anae109_3541 1 None None None 153003079 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Anae109_0202 186 COG2876 AroA, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 153003664 Common - major facilitator superfamily MFS_1 Anae109_0793 8 None None None 153004767 Common - protein of unknown function DUF1206 Anae109_1905 8 None None None 153004665 Nonpathogen - hypothetical protein Anae109_1803 3 None None None 153005403 Common - multi-sensor hybrid histidine kinase Anae109_2543 221 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153005737 Common - sigma54 specific transcriptional regulator, Fis family Anae109_2878 171 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 153003646 Common - ATP-NAD/AcoX kinase Anae109_0775 202 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 153002897 Nonpathogen - hypothetical protein Anae109_0018 1 None None None 153006945 Nonpathogen - protein of unknown function DUF395, YeeE/YedE Anae109_4108 4 None None None 153006924 Common - UspA domain protein Anae109_4087 154 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 153004420 Common - hypothetical protein Anae109_1557 34 COG3219 COG3219, Uncharacterized protein conserved in bacteria Function unknown 153006739 Nonpathogen - hypothetical protein Anae109_3901 1 None None None 153006889 Common - DNA-3-methyladenine glycosylase I Anae109_4052 132 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 153002974 Common - protein of unknown function DUF520 Anae109_0095 107 COG1666 COG1666, Uncharacterized protein conserved in bacteria Function unknown 153003779 Nonpathogen - PDZ/DHR/GLGF domain protein Anae109_0911 8 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 153005593 Common - Glycine hydroxymethyltransferase Anae109_2733 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 153006406 Common - glycerol kinase Anae109_3566 178 COG0554 GlpK, Glycerol kinase Energy production and conversion 153004360 Nonpathogen - Abortive infection protein Anae109_1494 4 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 153006661 Common - Exonuclease RNase T and DNA polymerase III Anae109_3823 23 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 153003756 Nonpathogen - hypothetical protein Anae109_0888 1 None None None 153003995 Common - uroporphyrinogen decarboxylase Anae109_1128 179 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 153006425 Nonpathogen - protein of unknown function DUF296 Anae109_3585 1 COG1661 COG1661, Predicted DNA-binding protein with PD1-like DNA-binding motif General function prediction only 153003026 Common - response regulator receiver protein Anae109_0149 223 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153003338 Common - gamma-glutamyltransferase Anae109_0464 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 153004440 Common - hypothetical protein Anae109_1577 3 None None None 153007057 Nonpathogen - hypothetical protein Anae109_4220 1 None None None 153007209 Common - signal transduction histidine kinase, nitrogen specific, NtrB Anae109_4372 223 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 153002990 Common - hypothetical protein Anae109_0113 15 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 153004662 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_1800 163 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153006550 Nonpathogen - hypothetical protein Anae109_3712 4 None None None 153004927 Common - pantetheine-phosphate adenylyltransferase Anae109_2065 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 153007287 Nonpathogen - hypothetical protein Anae109_4450 1 COG5617 COG5617, Predicted integral membrane protein Function unknown 153006484 Common - Thioredoxin domain Anae109_3645 160 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 153005571 Nonpathogen - protein of unknown function UPF0054 Anae109_2711 2 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 153004245 Nonpathogen - hypothetical protein Anae109_1379 2 None None None 153007252 Common - inner-membrane translocator Anae109_4415 150 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 153003953 Nonpathogen - hypothetical protein Anae109_1086 1 None None None 153003494 Common - hypothetical protein Anae109_0622 4 COG4493 COG4493, Uncharacterized protein conserved in bacteria Function unknown 153004379 Common - VWA containing CoxE family protein Anae109_1513 35 COG3552 CoxE, Protein containing von Willebrand factor type A (vWA) domain General function prediction only 153006420 Nonpathogen - hypothetical protein Anae109_3580 3 None None None 153006567 Nonpathogen - PBS lyase HEAT domain protein repeat-containing protein Anae109_3729 4 COG3202 COG3202, ATP/ADP translocase Energy production and conversion 153005064 Nonpathogen - hypothetical protein Anae109_2203 1 COG5569 COG5569, Uncharacterized conserved protein Function unknown 153005255 Common - protein of unknown function DUF6 transmembrane Anae109_2394 19 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 153004861 Common - lipoate-protein ligase B Anae109_1999 173 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 153004939 Common - aminotransferase class I and II Anae109_2077 233 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 153005513 Nonpathogen - hypothetical protein Anae109_2653 1 None None None 153006102 Nonpathogen - hypothetical protein Anae109_3250 1 None None None 153004824 Common - Methyltransferase type 11 Anae109_1962 56 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153004840 Common - Mammalian cell entry related domain protein Anae109_1978 12 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 153003443 Common - transcriptional regulator, TetR family Anae109_0570 102 COG1309 AcrR, Transcriptional regulator Transcription 153004624 Nonpathogen - hypothetical protein Anae109_1762 2 None None None 153005005 Common - DNA repair exonuclease, SbcC Anae109_2144 86 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 153006796 Common - alpha/beta hydrolase fold Anae109_3959 152 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153005667 Common - NADP oxidoreductase coenzyme F420-dependent Anae109_2808 52 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 153007018 Common - Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) Anae109_4181 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 153004342 Common - response regulator receiver protein Anae109_1476 199 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153003136 Common - Tetratricopeptide TPR_2 repeat protein Anae109_0259 20 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 153005291 Common - peptidase S9B dipeptidylpeptidase IV domain protein Anae109_2431 97 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 153003920 Nonpathogen - hypothetical protein Anae109_1052 1 None None None 153006437 Nonpathogen - nitrate reductase molybdenum cofactor assembly chaperone Anae109_3597 1 COG2180 NarJ, Nitrate reductase delta subunit Energy production and conversion 153005293 Common - molybdenum cofactor synthesis domain Anae109_2433 189 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 153005234 Common - glycoside hydrolase 15-related Anae109_2373 69 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 153002984 Nonpathogen - hypothetical protein Anae109_0107 3 None None None 153003114 Common - efflux transporter, RND family, MFP subunit Anae109_0237 157 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 153003893 Common - putative transcriptional regulator, GntR family Anae109_1025 168 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 153003339 Nonpathogen - putative CheW protein Anae109_0465 3 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153004357 Common - putative RNA methylase Anae109_1491 145 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 153004832 Nonpathogen - hypothetical protein Anae109_1970 1 None None None 153004164 Nonpathogen - hypothetical protein Anae109_1297 1 None None None 153003742 Common - ICE-like protease (caspase) p20 domain protein Anae109_0874 6 None None None 153005343 Common - hypothetical protein Anae109_2483 7 None None None 153003054 Nonpathogen - transglutaminase-like protein Anae109_0177 1 None None None 153003737 Nonpathogen - putative lipoprotein Anae109_0869 2 None None None 153003199 Nonpathogen - hypothetical protein Anae109_0324 1 None None None 153003278 Common - TGF-beta receptor type I/II extracellular region Anae109_0404 78 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 153004217 Common - Methyltransferase type 11 Anae109_1351 115 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153006121 Nonpathogen - protein of unknown function DUF1486 Anae109_3271 4 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 153003439 Common - major facilitator superfamily MFS_1 Anae109_0566 71 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 153003320 Common - integral membrane sensor signal transduction histidine kinase Anae109_0446 80 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153006656 Common - Nucleotidyl transferase Anae109_3818 146 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 153003578 Common - Tol-Pal system TolQ Anae109_0706 149 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 153007187 Common - response regulator receiver modulated PilZ sensor protein Anae109_4350 215 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 153005397 Common - putative serine protein kinase, PrkA Anae109_2537 71 COG2766 PrkA, Putative Ser protein kinase Signal transduction mechanisms 153003247 Common - Indole-3-glycerol-phosphate synthase Anae109_0373 212 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 153003334 Common - putative FHA domain containing protein Anae109_0460 16 COG3456 COG3456, Uncharacterized conserved protein, contains FHA domain Signal transduction mechanisms 153004904 Common - NUDIX hydrolase Anae109_2042 163 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 153003259 Common - pyruvate, phosphate dikinase Anae109_0385 233 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 153005275 Nonpathogen - hypothetical protein Anae109_2415 1 None None None 153004137 Common - putative deoxyguanosinetriphosphate triphosphohydrolase Anae109_1270 160 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 153005171 Common - histidinol-phosphate aminotransferase Anae109_2310 239 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 153006147 Nonpathogen - hypothetical protein Anae109_3301 1 None None None 153003683 Common - hypothetical protein Anae109_0813 13 None None None 153006465 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_3625 162 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153007329 Common - Tetratricopeptide TPR_2 repeat protein Anae109_4492 4 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 153003776 Common - protein of unknown function DUF59 Anae109_0908 146 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 153003805 Common - Tetratricopeptide TPR_2 repeat protein Anae109_0937 4 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 153004019 Common - tRNA/rRNA methyltransferase (SpoU) Anae109_1152 141 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 153006340 Common - SMP-30/Gluconolaconase/LRE domain protein Anae109_3498 6 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 153006862 Common - SEC-C motif domain protein Anae109_4025 4 COG3318 COG3318, Predicted metal-binding protein related to the C-terminal domain of SecA General function prediction only 153005645 Common - transcriptional regulator, CarD family Anae109_2786 82 COG1329 COG1329, Transcriptional regulators, similar to M. xanthus CarD Transcription 153005184 Common - protein of unknown function DUF1568 Anae109_2323 12 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 153005584 Common - virulence factor family protein Anae109_2724 19 COG3946 VirJ, Type IV secretory pathway, VirJ component Intracellular trafficking and secretion 153006140 Nonpathogen - hypothetical protein Anae109_3292 1 None None None 153005723 Common - cytochrome c oxidase subunit III Anae109_2864 12 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 153006312 Nonpathogen - hypothetical protein Anae109_3469 2 None None None 153002883 Common - DNA gyrase, B subunit Anae109_0004 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 153007143 Common - nickel-dependent hydrogenase large subunit Anae109_4306 95 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 153005347 Common - cysteine synthase A Anae109_2487 219 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 153006072 Common - Alcohol dehydrogenase GroES domain protein Anae109_3218 93 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 153006869 Nonpathogen - hypothetical protein Anae109_4032 2 None None None 153006351 Common - glutathione S-transferase-like protein Anae109_3509 16 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 153006310 Nonpathogen - hypothetical protein Anae109_3467 8 None None None 153004719 Nonpathogen - Fibronectin type III domain protein Anae109_1857 3 None None None 153006534 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Anae109_3696 205 COG0388 COG0388, Predicted amidohydrolase General function prediction only 153007037 Common - band 7 protein Anae109_4200 62 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 153004370 Common - acetyl-CoA acetyltransferase Anae109_1504 181 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 153004610 Nonpathogen - hypothetical protein Anae109_1748 1 None None None 153004944 Nonpathogen - hypothetical protein Anae109_2082 1 None None None 153003148 Common - carboxyl transferase Anae109_0271 217 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 153006168 Common - conserved hypothetical protein 730 Anae109_3325 107 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 153004820 Common - pseudouridine synthase, RluA family Anae109_1958 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 153006912 Common - RNA polymerase, sigma 32 subunit, RpoH Anae109_4075 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 153005531 Nonpathogen - hypothetical protein Anae109_2671 1 None None None 153003124 Common - ABC transporter related Anae109_0247 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 153004021 Common - 2-alkenal reductase Anae109_1154 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 153005463 Common - succinate dehydrogenase or fumarate reductase, flavoprotein subunit Anae109_2603 225 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 153003351 Nonpathogen - hypothetical protein Anae109_0477 1 None None None 153004619 Common - translation elongation factor G Anae109_1757 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 153005381 Common - metallophosphoesterase Anae109_2521 9 None None None 153005124 Common - peptidase S1 and S6 chymotrypsin/Hap Anae109_2263 176 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 153005121 Common - putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)-like protein Anae109_2260 75 COG2843 PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) Cell envelope biogenesis, outer membrane 153003152 Nonpathogen - hypothetical protein Anae109_0275 1 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 153004514 Nonpathogen - lipolytic protein G-D-S-L family Anae109_1651 2 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 153006319 Common - Tetratricopeptide TPR_2 repeat protein Anae109_3476 38 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153005972 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_3117 9 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153006042 Common - Linoleoyl-CoA desaturase Anae109_3187 36 COG3239 DesA, Fatty acid desaturase Lipid metabolism 153004726 Common - magnesium and cobalt transport protein CorA Anae109_1864 164 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 153004437 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Anae109_1574 112 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 153007001 Nonpathogen - Hemerythrin HHE cation binding domain protein Anae109_4164 8 None None None 153006860 Nonpathogen - hypothetical protein Anae109_4023 1 None None None 153006170 Common - UspA domain protein Anae109_3327 45 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 153005078 Common - flagellar assembly protein FliH, putative Anae109_2217 6 COG1317 FliH, Flagellar biosynthesis/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 153007120 Common - hypothetical protein Anae109_4283 22 COG3461 COG3461, Uncharacterized conserved protein Function unknown 153006415 Common - transport system permease protein Anae109_3575 172 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 153004268 Common - permease YjgP/YjgQ family protein Anae109_1402 52 COG0795 COG0795, Predicted permeases General function prediction only 153004707 Common - Glutamyl-tRNA reductase Anae109_1845 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 153006119 Common - Beta-glucosidase Anae109_3267 101 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 153003988 Common - outer membrane chaperone Skp (OmpH) Anae109_1121 54 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 153003186 Common - NAD+ synthetase Anae109_0311 216 COG0171 NadE, NAD synthase Coenzyme metabolism 153005952 Nonpathogen - hypothetical protein Anae109_3097 9 COG3671 COG3671, Predicted membrane protein Function unknown 153003680 Nonpathogen - hypothetical protein Anae109_0810 1 None None None 153004798 Common - ribosomal protein S11 Anae109_1936 247 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 153003473 Common - transcriptional regulator, SARP family Anae109_0600 138 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 153003839 Common - adventurous gliding motility protein R Anae109_0971 52 COG0003 ArsA, Predicted ATPase involved in chromosome partitioning Cell division and chromosome partitioning 153006710 Common - protein of unknown function DUF1568 Anae109_3872 22 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 153005697 Common - hypothetical protein Anae109_2838 6 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 153004080 Common - hypothetical protein Anae109_1213 25 COG3875 COG3875, Uncharacterized conserved protein Function unknown 153006852 Common - transcriptional regulator protein-like protein Anae109_4015 43 COG2378 COG2378, Predicted transcriptional regulator Transcription 153003549 Common - Tetratricopeptide TPR_2 repeat protein Anae109_0677 55 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 153007196 Nonpathogen - hypothetical protein Anae109_4359 1 None None None 153006414 Common - periplasmic binding protein Anae109_3574 139 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 153006339 Common - protein of unknown function DUF1255 Anae109_3497 50 COG3123 COG3123, Uncharacterized protein conserved in bacteria Function unknown 153006952 Nonpathogen - hypothetical protein Anae109_4115 1 None None None 153004363 Nonpathogen - hypothetical protein Anae109_1497 1 None None None 153005946 Nonpathogen - exporter of the RND superfamily protein-like protein Anae109_3091 3 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 153003410 Common - Spore coat U domain protein Anae109_0537 22 COG5430 COG5430, Uncharacterized secreted protein Function unknown 153003551 Nonpathogen - hypothetical protein Anae109_0679 6 None None None 153003969 Common - branched-chain amino acid aminotransferase Anae109_1102 220 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 153006031 Common - basic membrane lipoprotein Anae109_3176 98 COG1744 Med, Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein General function prediction only 153006103 Common - bifunctional deaminase-reductase domain protein Anae109_3251 55 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 153006246 Common - OmpA/MotB domain protein Anae109_3403 144 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 153004007 Common - protein of unknown function DUF448 Anae109_1140 13 COG2740 COG2740, Predicted nucleic-acid-binding protein implicated in transcription termination Transcription 153003144 Common - ribosomal protein L11 methyltransferase Anae109_0267 171 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 153004778 Common - ribosomal protein L22 Anae109_1916 209 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 153005955 Common - phosphate acetyltransferase Anae109_3100 178 COG0280 Pta, Phosphotransacetylase Energy production and conversion 153005496 Common - SpoIID/LytB domain Anae109_2636 47 COG2385 SpoIID, Sporulation protein and related proteins Cell division and chromosome partitioning 153002905 Common - UBA/THIF-type NAD/FAD binding protein Anae109_0026 13 COG1179 COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Coenzyme metabolism 153004126 Common - General secretory system II protein E domain protein Anae109_1259 18 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 153005318 Nonpathogen - hypothetical protein Anae109_2458 2 None None None 153006220 Nonpathogen - hypothetical protein Anae109_3377 2 None None None 153006233 Nonpathogen - hypothetical protein Anae109_3390 1 None None None 153005747 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Anae109_2888 10 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 153002927 Common - hypothetical protein Anae109_0048 13 None None None 153005523 Common - multi-sensor signal transduction histidine kinase Anae109_2663 222 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 153006209 Nonpathogen - hypothetical protein Anae109_3366 2 None None None 153004453 Nonpathogen - hypothetical protein Anae109_1590 1 None None None 153003452 Nonpathogen - hypothetical protein Anae109_0579 10 None None None 153007138 Common - DNA ligase I, ATP-dependent Dnl1 Anae109_4301 104 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 153004190 Common - protein-export membrane protein SecD Anae109_1323 215 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 153005244 Common - efflux transporter, RND family, MFP subunit Anae109_2383 146 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153004388 Common - 2-alkenal reductase Anae109_1523 234 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 153004868 Common - aminotransferase class I and II Anae109_2006 229 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 153005632 Nonpathogen - hypothetical protein Anae109_2773 1 None None None 153003813 Common - ABC transporter related Anae109_0945 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 153007078 Common - OsmC family protein Anae109_4241 43 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 153003164 Nonpathogen - Biopolymer transport protein ExbD/TolR Anae109_0288 3 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 153003187 Nonpathogen - ABC-type Fe3+ transporter, periplasmic ligand binding protein Anae109_0312 1 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 153003027 Common - phosphoesterase DHHA1 Anae109_0150 12 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 153004753 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Anae109_1891 106 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 153005915 Common - hypothetical protein Anae109_3060 27 None None None 153006604 Common - Radical SAM domain protein Anae109_3766 61 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 153005361 Common - FHA domain containing protein Anae109_2501 40 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 153003528 Common - methyl-accepting chemotaxis sensory transducer Anae109_0656 151 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153005378 Nonpathogen - hypothetical protein Anae109_2518 1 None None None 153006182 Common - transport-associated Anae109_3339 13 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 153006737 Common - putative esterase Anae109_3899 27 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 153004515 Common - GreA/GreB family elongation factor Anae109_1652 163 COG0782 GreA, Transcription elongation factor Transcription 153003003 Common - SpoVG family protein Anae109_0126 24 COG2088 SpoVG, Uncharacterized protein, involved in the regulation of septum location Cell envelope biogenesis, outer membrane 153004053 Common - signal peptide peptidase SppA, 36K type Anae109_1186 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 153004759 Common - Tetratricopeptide TPR_2 repeat protein Anae109_1897 86 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153003308 Nonpathogen - hypothetical protein Anae109_0434 4 None None None 153004914 Common - Glu/Leu/Phe/Val dehydrogenase Anae109_2052 180 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 153005557 Common - protein of unknown function DUF152 Anae109_2697 182 COG1496 COG1496, Uncharacterized conserved protein Function unknown 153005144 Nonpathogen - hypothetical protein Anae109_2283 2 None None None 153005112 Common - ferric uptake regulator, Fur family Anae109_2251 194 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 153006943 Common - Polysulphide reductase NrfD Anae109_4106 21 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 153003098 Common - major facilitator superfamily MFS_1 Anae109_0221 70 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153005740 Common - putative thioesterase Anae109_2881 14 COG0824 FcbC, Predicted thioesterase General function prediction only 153004635 Common - protein of unknown function DUF214 Anae109_1773 42 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 153006205 Common - alpha/beta hydrolase fold Anae109_3362 148 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153006258 Nonpathogen - hypothetical protein Anae109_3415 3 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153004787 Common - ribosomal protein S8 Anae109_1925 247 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 153006565 Common - hypothetical protein Anae109_3727 19 None None None 153005475 Common - Non-specific protein-tyrosine kinase Anae109_2615 122 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 153006583 Common - competence/damage-inducible protein CinA Anae109_3745 169 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 153006187 Nonpathogen - protein of unknown function DUF395 YeeE/YedE Anae109_3344 20 None None None 153003673 Common - histidine kinase Anae109_0803 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153007188 Common - GCN5-related N-acetyltransferase Anae109_4351 51 COG2153 ElaA, Predicted acyltransferase General function prediction only 153003450 Common - regulatory protein ArsR Anae109_0577 33 COG0640 ArsR, Predicted transcriptional regulators Transcription 153003161 Nonpathogen - hypothetical protein Anae109_0284 1 None None None 153004812 Nonpathogen - hypothetical protein Anae109_1950 3 None None None 153006888 Common - urease accessory protein UreG Anae109_4051 114 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 153004603 Common - ybaK/ebsC protein Anae109_1741 122 COG2606 EbsC, Uncharacterized conserved protein Function unknown 153005388 Common - TonB family protein Anae109_2528 4 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 153003599 Common - general secretion pathway protein G Anae109_0727 76 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 153003866 Nonpathogen - HNH endonuclease Anae109_0998 3 COG1403 McrA, Restriction endonuclease Defense mechanisms 153006039 Nonpathogen - hypothetical protein Anae109_3184 1 None None None 153003843 Common - PHA accumulation regulator DNA-binding protein Anae109_0975 65 COG5394 COG5394, Uncharacterized protein conserved in bacteria Function unknown 153003131 Common - protein of unknown function DUF163 Anae109_0254 167 COG1576 COG1576, Uncharacterized conserved protein Function unknown 153006991 Common - proton-translocating NADH-quinone oxidoreductase, chain N Anae109_4154 209 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 153004209 Nonpathogen - hypothetical protein Anae109_1342 1 None None None 153006152 Common - nitroreductase Anae109_3308 54 COG0778 NfnB, Nitroreductase Energy production and conversion 153003636 Nonpathogen - protein of unknown function DUF81 Anae109_0765 1 COG0730 COG0730, Predicted permeases General function prediction only 153006368 Common - protein of unknown function DUF583 Anae109_3528 70 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 153004283 Nonpathogen - hypothetical protein Anae109_1417 2 None None None 153005659 Nonpathogen - hypothetical protein Anae109_2800 4 None None None 153007240 Common - Sulfate adenylyltransferase Anae109_4403 42 COG2046 MET3, ATP sulfurylase (sulfate adenylyltransferase) Inorganic ion transport and metabolism 153003540 Common - twitching motility protein Anae109_0668 215 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 153003955 Common - isochorismatase hydrolase Anae109_1088 70 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 153006937 Common - heavy metal translocating P-type ATPase Anae109_4100 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 153005443 Nonpathogen - PHP domain protein Anae109_2583 27 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 153006776 Nonpathogen - NHL repeat protein Anae109_3939 6 COG4257 Vgb, Streptogramin lyase Defense mechanisms 153003485 Common - Diaminopimelate epimerase Anae109_0613 195 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 153004150 Common - NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Anae109_1283 12 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 153006815 Common - seryl-tRNA synthetase Anae109_3978 243 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 153002919 Common - amino acid-binding ACT domain protein Anae109_0040 38 COG4747 COG4747, ACT domain-containing protein General function prediction only 153005357 Common - 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Anae109_2497 185 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 153005229 Common - methyl-accepting chemotaxis sensory transducer Anae109_2368 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153005454 Nonpathogen - hypothetical protein Anae109_2594 3 None None None 153003887 Common - hypothetical protein Anae109_1019 16 COG2267 PldB, Lysophospholipase Lipid metabolism 153003427 Nonpathogen - protein of unknown function DUF1468 Anae109_0554 3 None None None 153006330 Common - CBS domain containing protein Anae109_3488 143 COG0517 COG0517, FOG: CBS domain General function prediction only 153007246 Nonpathogen - LigA Anae109_4409 1 None None None 153006520 Nonpathogen - hypothetical protein Anae109_3681 1 None None None 153003694 Common - response regulator receiver protein Anae109_0824 221 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153006642 Common - protein of unknown function DUF833 Anae109_3804 47 COG3332 COG3332, Uncharacterized conserved protein Function unknown 153004395 Common - response regulator receiver protein Anae109_1530 214 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153003820 Common - peptidase S9 prolyl oligopeptidase active site domain protein Anae109_0952 133 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 153004692 Nonpathogen - cytochrome c family protein Anae109_1830 2 None None None 153005898 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_3042 162 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153007300 Common - putative CheW protein Anae109_4463 10 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153007021 Nonpathogen - hypothetical protein Anae109_4184 1 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153005281 Nonpathogen - hypothetical protein Anae109_2421 2 None None None 153006702 Common - short-chain dehydrogenase/reductase SDR Anae109_3864 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153003074 Common - histidine triad (HIT) protein Anae109_0197 226 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 153003533 Common - protein of unknown function DUF28 Anae109_0661 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 153003046 Common - Biopolymer transport protein ExbD/TolR Anae109_0169 23 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 153004597 Common - transcriptional regulator, SARP family Anae109_1735 43 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 153005676 Nonpathogen - hypothetical protein Anae109_2817 2 None None None 153006516 Common - IS66 Orf2 family protein Anae109_3677 50 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 153003975 Common - RNA polymerase sigma-70 Anae109_1108 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 153004521 Nonpathogen - hypothetical protein Anae109_1658 1 None None None 153004045 Common - putative lipoprotein transmembrane Anae109_1178 18 None None None 153006509 Nonpathogen - hypothetical protein Anae109_3670 1 None None None 153003468 Common - carbohydrate kinase, thermoresistant glucokinase family Anae109_0595 80 COG3265 GntK, Gluconate kinase Carbohydrate transport and metabolism 153006730 Common - Polypeptide-transport-associated domain protein FtsQ-type Anae109_3892 43 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 153004713 Common - ribosomal protein L3 Anae109_1851 234 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 153006142 Nonpathogen - hypothetical protein Anae109_3294 1 None None None 153003386 Common - hydrogenase accessory protein HypB Anae109_0513 107 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 153004746 Common - phenylalanyl-tRNA synthetase, beta subunit Anae109_1884 218 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 153006445 Common - threonine synthase Anae109_3605 117 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 153005263 Common - alpha/beta hydrolase fold Anae109_2403 66 COG0429 COG0429, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 153003829 Nonpathogen - hypothetical protein Anae109_0961 1 None None None 153005615 Common - response regulator receiver protein Anae109_2756 221 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153003686 Common - HNH endonuclease Anae109_0816 5 COG1403 McrA, Restriction endonuclease Defense mechanisms 153005180 Common - glutamine amidotransferase class-II Anae109_2319 95 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 153006478 Common - YceI family protein Anae109_3639 119 COG2353 COG2353, Uncharacterized conserved protein Function unknown 153007260 Common - hypothetical protein Anae109_4423 12 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 153004349 Common - integral membrane protein MviN Anae109_1483 194 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 153005800 Common - GTP-binding protein HSR1-related Anae109_2941 18 COG1160 COG1160, Predicted GTPases General function prediction only 153007267 Common - protein tyrosine phosphatase Anae109_4430 129 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 153003741 Common - MotA/TolQ/ExbB proton channel Anae109_0873 138 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 153005566 Nonpathogen - type IV pilus assembly PilZ Anae109_2706 3 None None None 153007322 Common - ATP synthase F0, B subunit Anae109_4485 111 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 153005978 Common - ABC transporter related Anae109_3123 240 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 153006998 Common - hypothetical protein Anae109_4161 6 None None None 153004101 Nonpathogen - hypothetical protein Anae109_1234 1 None None None 153003516 Common - response regulator receiver modulated CheB methylesterase Anae109_0644 216 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 153004512 Common - AMP-dependent synthetase and ligase Anae109_1649 210 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153004358 Common - histidine kinase Anae109_1492 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153005825 Nonpathogen - hypothetical protein Anae109_2967 1 None None None 153007068 Nonpathogen - hypothetical protein Anae109_4231 4 None None None 153003193 Common - 4-alpha-glucanotransferase Anae109_0318 120 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 153005627 Common - hypothetical protein Anae109_2768 31 None None None 153004275 Common - glycosyl transferase group 1 Anae109_1409 196 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153005821 Common - malate synthase A Anae109_2963 131 COG2224 AceA, Isocitrate lyase Energy production and conversion 153002964 Nonpathogen - hypothetical protein Anae109_0085 2 None None None 153004000 Common - exodeoxyribonuclease VII, small subunit Anae109_1133 73 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 153004581 Nonpathogen - hypothetical protein Anae109_1718 1 None None None 153003289 Common - two component transcriptional regulator, winged helix family Anae109_0415 216 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153005540 Common - Argininosuccinate synthase Anae109_2680 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 153005333 Nonpathogen - hypothetical protein Anae109_2473 1 None None None 153003419 Common - OmpA/MotB domain protein Anae109_0546 172 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 153006532 Common - Tetratricopeptide TPR_2 repeat protein Anae109_3694 82 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 153004593 Common - cation diffusion facilitator family transporter Anae109_1731 168 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 153004503 Common - sulfate ABC transporter, inner membrane subunit CysW Anae109_1640 178 COG4208 CysW, ABC-type sulfate transport system, permease component Inorganic ion transport and metabolism 153003209 Common - putative lipoprotein Anae109_0335 14 None None None 153007030 Common - hypothetical protein Anae109_4193 6 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 153005328 Common - Lytic transglycosylase catalytic Anae109_2468 132 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 153005853 Nonpathogen - hypothetical protein Anae109_2997 2 COG3115 ZipA, Cell division protein Cell division and chromosome partitioning 153004709 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_1847 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153005527 Common - 5,10-methylenetetrahydrofolate reductase Anae109_2667 139 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 153006770 Common - transcriptional regulator, BadM/Rrf2 family Anae109_3932 166 COG1959 COG1959, Predicted transcriptional regulator Transcription 153003610 Common - ribonuclease, Rne/Rng family Anae109_0738 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 153003523 Nonpathogen - hypothetical protein Anae109_0651 1 None None None 153005093 Common - alpha-L-glutamate ligase, RimK family Anae109_2232 83 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 153006974 Nonpathogen - hypothetical protein Anae109_4137 1 None None None 153005423 Common - H+transporting two-sector ATPase alpha/beta subunit central region Anae109_2563 247 COG1156 NtpB, Archaeal/vacuolar-type H+-ATPase subunit B Energy production and conversion 153006304 Common - acetate--CoA ligase Anae109_3461 215 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 153003901 Common - multi-sensor signal transduction histidine kinase Anae109_1033 210 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153007262 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_4425 174 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153006095 Common - Amidase Anae109_3242 210 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 153007339 Common - Cobyrinic acid ac-diamide synthase Anae109_4502 205 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 153004142 Common - Arginase/agmatinase/formiminoglutamase Anae109_1275 152 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 153004390 Common - GMP synthase, large subunit Anae109_1525 240 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 153007105 Common - Fmu (Sun) domain protein Anae109_4268 190 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 153005938 Common - hypothetical protein Anae109_3083 32 COG3571 COG3571, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 153004766 Common - manganese and iron superoxide dismutase Anae109_1904 187 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 153005749 Common - Ferritin Dps family protein Anae109_2890 141 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 153003058 Common - acetylglutamate kinase Anae109_0181 218 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 153004771 Common - translation elongation factor G Anae109_1909 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 153005108 Common - hypothetical protein Anae109_2247 20 None None None 153006295 Common - hypothetical protein Anae109_3452 24 None None None 153003394 Common - glycosyl transferase family 39 Anae109_0521 56 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 153005304 Nonpathogen - transcriptional regulator, TraR/DksA family Anae109_2444 1 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 153003252 Common - glycosyl transferase family 25 Anae109_0378 12 COG3306 COG3306, Glycosyltransferase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 153004643 Nonpathogen - kinase-like protein Anae109_1781 6 COG4639 COG4639, Predicted kinase General function prediction only 153005213 Common - response regulator receiver sensor signal transduction histidine kinase Anae109_2352 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153006324 Common - fumarylacetoacetate (FAA) hydrolase Anae109_3482 100 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 153006884 Common - Urease accessory protein UreD Anae109_4047 77 COG0829 UreH, Urease accessory protein UreH Posttranslational modification, protein turnover, chaperones 153006529 Common - protein of unknown function DUF583 Anae109_3691 28 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 153006251 Common - histidine kinase Anae109_3408 219 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 153006012 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Anae109_3157 14 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 153006689 Common - protein of unknown function Met10 Anae109_3851 109 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 153004224 Nonpathogen - hypothetical protein Anae109_1358 1 None None None 153006872 Common - ROK family protein Anae109_4035 58 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 153006570 Common - Alcohol dehydrogenase GroES domain protein Anae109_3732 205 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 153006491 Common - putative adenylate/guanylate cyclase Anae109_3652 37 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 153005426 Nonpathogen - H+transporting two-sector ATPase C (AC39) subunit Anae109_2566 1 COG1527 NtpC, Archaeal/vacuolar-type H+-ATPase subunit C Energy production and conversion 153003796 Nonpathogen - Radical SAM domain protein Anae109_0928 2 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 153004449 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Anae109_1586 197 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 153002997 Common - ribosomal protein L9 Anae109_0120 215 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 153005999 Common - transport-associated Anae109_3144 13 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 153005028 Common - thiamine biosynthesis protein ThiC Anae109_2167 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 153006435 Common - nitrate reductase, alpha subunit Anae109_3595 130 COG5013 NarG, Nitrate reductase alpha subunit Energy production and conversion 153003785 Common - translation initiation factor SUI1 Anae109_0917 40 COG0023 SUI1, Translation initiation factor 1 (eIF-1/SUI1) and related proteins Translation, ribosomal structure and biogenesis 153003616 Nonpathogen - export protein FliQ family 3 Anae109_0744 1 COG1987 FliQ, Flagellar biosynthesis pathway, component FliQ Cell motility and secretion / Intracellular trafficking and secretion 153002948 Common - lipolytic protein G-D-S-L family Anae109_0069 56 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 153003872 Common - hypothetical protein Anae109_1004 12 None None None 153006728 Nonpathogen - hypothetical protein Anae109_3890 1 None None None 153003459 Nonpathogen - hypothetical protein Anae109_0586 2 None None None 153005930 Common - HNH endonuclease Anae109_3075 4 COG1403 McrA, Restriction endonuclease Defense mechanisms 153007154 Nonpathogen - hypothetical protein Anae109_4317 1 None None None 153005846 Common - hypothetical protein Anae109_2990 8 None None None 153006966 Common - Alcohol dehydrogenase zinc-binding type 2 Anae109_4129 203 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 153003633 Common - RNA polymerase, sigma 70 subunit, RpoD Anae109_0762 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 153005859 Common - aldehyde dehydrogenase Anae109_3003 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 153006671 Common - membrane protein Anae109_3833 54 COG4327 COG4327, Predicted membrane protein Function unknown 153007126 Nonpathogen - phospholipid/glycerol acyltransferase Anae109_4289 1 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 153003922 Common - oxidoreductase FAD/NAD(P)-binding domain protein Anae109_1054 168 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 153006011 Common - Cupin 2 conserved barrel domain protein Anae109_3156 28 COG4101 COG4101, Predicted mannose-6-phosphate isomerase Carbohydrate transport and metabolism 153004934 Common - carbamoyl-phosphate synthase, large subunit Anae109_2072 235 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 153006795 Common - peptidase U62 modulator of DNA gyrase Anae109_3958 169 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 153005704 Common - hypothetical protein Anae109_2845 5 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 153003935 Common - DNA binding domain, excisionase family Anae109_1068 6 COG2452 COG2452, Predicted site-specific integrase-resolvase DNA replication, recombination, and repair 153003377 Nonpathogen - hypothetical protein Anae109_0504 1 None None None 153004162 Common - NADH dehydrogenase (quinone) Anae109_1295 183 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 153004676 Common - polysaccharide biosynthesis protein Anae109_1814 28 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 153005620 Common - uncharacterised conserved protein UCP033563 Anae109_2761 44 COG4198 COG4198, Uncharacterized conserved protein Function unknown 153003086 Common - 3-dehydroquinate dehydratase, type II Anae109_0209 169 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 153006827 Common - hypothetical protein Anae109_3990 7 None None None 153004033 Common - carbonic anhydrase Anae109_1166 32 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 153003587 Common - GCN5-related N-acetyltransferase Anae109_0715 6 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 153003343 Common - CheA signal transduction histidine kinase Anae109_0469 221 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 153003989 Common - UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase Anae109_1122 146 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 153007002 Nonpathogen - ParB domain protein nuclease Anae109_4165 3 None None None 153004178 Common - (p)ppGpp synthetase I, SpoT/RelA Anae109_1311 207 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 153004591 Nonpathogen - hypothetical protein Anae109_1729 3 None None None 153003015 Common - galactose-1-phosphate uridylyltransferase Anae109_0138 78 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 153003639 Common - peptide deformylase Anae109_0768 215 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 153007314 Nonpathogen - Tetratricopeptide TPR_4 Anae109_4477 6 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153003804 Common - hypothetical protein Anae109_0936 9 None None None 153004683 Common - glycosyl transferase family 2 Anae109_1821 154 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 153005102 Nonpathogen - Septum formation initiator Anae109_2241 6 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 153005367 Common - transcriptional regulator, TetR family Anae109_2507 138 COG1309 AcrR, Transcriptional regulator Transcription 153006223 Common - ABC transporter related Anae109_3380 244 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 153003246 Common - Phosphoribosylanthranilate isomerase Anae109_0372 187 COG0135 TrpF, Phosphoribosylanthranilate isomerase Amino acid transport and metabolism 153004573 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Anae109_1710 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 153003201 Common - Arginase/agmatinase/formiminoglutamase Anae109_0327 130 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 153004170 Nonpathogen - response regulator receiver and SARP domain protein Anae109_1303 1 COG3947 COG3947, Response regulator containing CheY-like receiver and SARP domains Signal transduction mechanisms 153005728 Nonpathogen - hypothetical protein Anae109_2869 1 None None None 153004474 Nonpathogen - hypothetical protein Anae109_1611 1 None None None 153004505 Common - Phosphoadenylyl-sulfate reductase (thioredoxin), Adenylyl-sulfate kinase Anae109_1642 180 COG0529 CysC, Adenylylsulfate kinase and related kinases Inorganic ion transport and metabolism 153005287 Common - cytochrome b subunit of nitric oxide reductase Anae109_2427 73 COG3256 NorB, Nitric oxide reductase large subunit Inorganic ion transport and metabolism 153004405 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Anae109_1540 42 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 153003281 Common - hypothetical protein Anae109_0407 7 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 153007175 Common - glutamyl-tRNA(Gln) amidotransferase, A subunit Anae109_4338 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 153004225 Common - Fructose-bisphosphate aldolase Anae109_1359 61 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 153005006 Common - nuclease SbcCD, D subunit Anae109_2145 114 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 153003570 Common - protein of unknown function DUF490 Anae109_0698 25 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 153005306 Common - metal dependent phosphohydrolase Anae109_2446 48 COG3481 COG3481, Predicted HD-superfamily hydrolase General function prediction only 153006159 Common - glycogen debranching enzyme GlgX Anae109_3315 162 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 153005650 Nonpathogen - UspA domain protein Anae109_2791 3 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 153007017 Common - Thimet oligopeptidase Anae109_4180 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 153003894 Nonpathogen - hypothetical protein Anae109_1026 1 None None None 153005081 Common - DNA-directed RNA polymerase, beta' subunit Anae109_2220 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 153003797 Common - transcriptional regulator, XRE family Anae109_0929 121 COG1396 HipB, Predicted transcriptional regulators Transcription 153005692 Common - hypothetical protein Anae109_2833 20 COG5552 COG5552, Uncharacterized conserved protein Function unknown 153003853 Nonpathogen - hypothetical protein Anae109_0985 1 None None None 153004625 Common - protein of unknown function DUF218 Anae109_1763 90 COG1434 COG1434, Uncharacterized conserved protein Function unknown 153006625 Nonpathogen - hypothetical protein Anae109_3787 1 None None None 153006673 Common - protein of unknown function DUF485 Anae109_3835 50 COG3162 COG3162, Predicted membrane protein Function unknown 153007211 Nonpathogen - hypothetical protein Anae109_4374 1 None None None 153005755 Nonpathogen - Electron transfer flavoprotein alpha/beta-subunit Anae109_2896 2 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 153006128 Nonpathogen - hypothetical protein Anae109_3280 1 None None None 153003669 Common - anti-sigma-factor antagonist Anae109_0799 33 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 153003684 Common - Exonuclease RNase T and DNA polymerase III Anae109_0814 83 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 153002884 Common - 3-oxoacyl-(acyl-carrier-protein) synthase III Anae109_0005 214 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 153004301 Common - protein of unknown function DUF162 Anae109_1435 32 COG1556 COG1556, Uncharacterized conserved protein Function unknown 153003413 Common - GAF sensor hybrid histidine kinase Anae109_0540 226 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153004315 Nonpathogen - HNH endonuclease Anae109_1449 3 COG1403 McrA, Restriction endonuclease Defense mechanisms 153005030 Nonpathogen - hypothetical protein Anae109_2169 1 None None None 153006333 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Anae109_3491 16 COG3565 COG3565, Predicted dioxygenase of extradiol dioxygenase family General function prediction only 153004213 Common - thiazole biosynthesis family protein Anae109_1346 166 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 153003762 Common - ABC transporter related Anae109_0894 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 153006807 Nonpathogen - TadE family protein Anae109_3970 1 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 153003707 Common - Leucyltransferase Anae109_0837 134 COG2360 Aat, Leu/Phe-tRNA-protein transferase Posttranslational modification, protein turnover, chaperones 153005222 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Anae109_2361 247 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 153006800 Common - TPR repeat-containing protein Anae109_3963 88 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153004128 Nonpathogen - hypothetical protein Anae109_1261 2 None None None 153004889 Common - phosphoenolpyruvate-protein phosphotransferase Anae109_2027 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 153007038 Common - putative glycosyl hydrolase Anae109_4201 13 COG3934 COG3934, Endo-beta-mannanase Carbohydrate transport and metabolism 153006993 Common - proton-translocating NADH-quinone oxidoreductase, chain L Anae109_4156 209 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 153006719 Common - phospho-N-acetylmuramoyl-pentapeptide-transferase Anae109_3881 211 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 153007289 Common - Inorganic diphosphatase Anae109_4452 98 COG3808 OVP1, Inorganic pyrophosphatase Energy production and conversion 153004762 Common - NAD-dependent epimerase/dehydratase Anae109_1900 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153006424 Common - hypothetical protein Anae109_3584 4 COG0546 Gph, Predicted phosphatases General function prediction only 153006564 Nonpathogen - hypothetical protein Anae109_3726 1 None None None 153004081 Common - HAD-superfamily subfamily IB hydrolase, TIGR01490 Anae109_1214 126 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 153004633 Common - PAS/PAC sensor hybrid histidine kinase Anae109_1771 201 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153006380 Nonpathogen - hypothetical protein Anae109_3540 8 COG4663 FcbT1, TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 153007027 Common - aspartate-semialdehyde dehydrogenase Anae109_4190 189 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 153006137 Nonpathogen - hypothetical protein Anae109_3289 1 None None None 153006892 Common - protein of unknown function DUF81 Anae109_4055 8 COG0730 COG0730, Predicted permeases General function prediction only 153002906 Common - multi-sensor hybrid histidine kinase Anae109_0027 208 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153002896 Nonpathogen - hypothetical protein Anae109_0017 1 None None None 153005837 Nonpathogen - hypothetical protein Anae109_2979 1 None None None 153004509 Common - metallophosphoesterase Anae109_1646 29 COG1409 Icc, Predicted phosphohydrolases General function prediction only 153005183 Common - YD repeat protein Anae109_2322 61 COG3209 RhsA, Rhs family protein Cell envelope biogenesis, outer membrane 153005250 Common - HAD-superfamily hydrolase, subfamily IIB Anae109_2389 76 COG1877 OtsB, Trehalose-6-phosphatase Carbohydrate transport and metabolism 153003934 Nonpathogen - hypothetical protein Anae109_1067 4 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 153003676 Common - UspA domain protein Anae109_0806 172 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 153006064 Common - transcriptional regulator, LysR family Anae109_3210 157 COG0583 LysR, Transcriptional regulator Transcription 153003844 Nonpathogen - MJ0042 family finger-like protein Anae109_0976 2 COG5373 COG5373, Predicted membrane protein Function unknown 153004773 Common - ribosomal protein S10 Anae109_1911 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 153003100 Nonpathogen - hypothetical protein Anae109_0223 6 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 153005892 Nonpathogen - hypothetical protein Anae109_3036 1 None None None 153006750 Common - multi-sensor signal transduction histidine kinase Anae109_3912 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153006379 Common - methyl-accepting chemotaxis sensory transducer Anae109_3539 154 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153003594 Common - Fimbrial assembly family protein Anae109_0722 12 COG4972 PilM, Tfp pilus assembly protein, ATPase PilM Cell motility and secretion / Intracellular trafficking and secretion 153004011 Common - tRNA pseudouridine synthase B Anae109_1144 244 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 153003369 Nonpathogen - protein of unknown function DUF214 Anae109_0496 2 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 153005039 Common - metallophosphoesterase Anae109_2178 61 COG0622 COG0622, Predicted phosphoesterase General function prediction only 153005790 Common - L-threonine 3-dehydrogenase Anae109_2931 210 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 153004833 Nonpathogen - transcriptional regulator, XRE family Anae109_1971 1 COG1476 COG1476, Predicted transcriptional regulators Transcription 153004649 Common - acriflavin resistance protein Anae109_1787 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 153006871 Common - Antibiotic biosynthesis monooxygenase Anae109_4034 33 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 153004936 Common - ATP-dependent DNA helicase RecG Anae109_2074 230 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 153007093 Common - diguanylate phosphodiesterase Anae109_4256 117 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 153003431 Common - major facilitator superfamily MFS_1 Anae109_0558 88 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153007208 Nonpathogen - putative sigma 54 modulation protein/ribosomal protein S30EA Anae109_4371 3 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 153007303 Common - histidine kinase Anae109_4466 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153003462 Common - putative transcriptional regulator Anae109_0589 35 COG1510 COG1510, Predicted transcriptional regulators Transcription 153004350 Nonpathogen - hypothetical protein Anae109_1484 2 COG4575 ElaB, Uncharacterized conserved protein Function unknown 153002920 Common - Phenylacetate--CoA ligase Anae109_0041 124 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 153003548 Nonpathogen - hypothetical protein Anae109_0676 1 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 153003002 Common - ribose-phosphate pyrophosphokinase Anae109_0125 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 153005628 Nonpathogen - hypothetical protein Anae109_2769 1 None None None 153003400 Common - protein of unknown function DUF195 Anae109_0527 143 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 153006084 Nonpathogen - hypothetical protein Anae109_3230 1 None None None 153005738 Common - amino acid-binding ACT domain protein Anae109_2879 30 COG4747 COG4747, ACT domain-containing protein General function prediction only 153004307 Common - signal transduction histidine kinase, LytS Anae109_1441 104 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 153007342 Common - single-stranded nucleic acid binding R3H domain protein Anae109_4505 43 COG1847 Jag, Predicted RNA-binding protein General function prediction only 153003818 Common - deoxyribose-phosphate aldolase Anae109_0950 137 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 153006617 Common - putative PTS IIA-like nitrogen-regulatory protein PtsN Anae109_3779 74 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 153006572 Nonpathogen - LrgA family protein Anae109_3734 1 COG1380 COG1380, Putative effector of murein hydrolase LrgA General function prediction only 153006803 Common - type II secretion system protein E Anae109_3966 169 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 153003360 Common - Lytic transglycosylase catalytic Anae109_0486 167 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 153003112 Common - protein kinase Anae109_0235 155 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153004135 Common - protein of unknown function DUF52 Anae109_1268 65 COG1355 COG1355, Predicted dioxygenase General function prediction only 153006557 Common - thioesterase superfamily protein Anae109_3719 46 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 153005299 Common - response regulator receiver protein Anae109_2439 169 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153005088 Nonpathogen - preprotein translocase, SecE subunit Anae109_2227 2 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 153007204 Common - PAS/PAC sensor hybrid histidine kinase Anae109_4367 213 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153006882 Nonpathogen - hypothetical protein Anae109_4045 1 None None None 153004882 Nonpathogen - hypothetical protein Anae109_2020 5 None None None 153003316 Common - response regulator receiver protein Anae109_0442 221 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153006521 Common - glycosyl transferase family 9 Anae109_3683 35 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 153005389 Common - glycosyl transferase family 51 Anae109_2529 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 153007062 Common - putative transcriptional regulator, MerR family Anae109_4225 26 COG0789 SoxR, Predicted transcriptional regulators Transcription 153005311 Common - DNA polymerase III, delta prime subunit Anae109_2451 207 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 153004054 Common - thymidylate synthase, flavin-dependent Anae109_1187 55 COG1351 THY1, Predicted alternative thymidylate synthase Nucleotide transport and metabolism 153005257 Common - amino acid-binding ACT domain protein Anae109_2396 36 COG4747 COG4747, ACT domain-containing protein General function prediction only 153006615 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_3777 171 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153006633 Common - histidine kinase Anae109_3795 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153003379 Common - sigma54 specific transcriptional regulator, Fis family Anae109_0506 175 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 153005886 Common - nitrogenase iron protein Anae109_3030 101 COG1348 NifH, Nitrogenase subunit NifH (ATPase) Inorganic ion transport and metabolism 153007341 Common - methyltransferase GidB Anae109_4504 55 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 153003870 Nonpathogen - hypothetical protein Anae109_1002 1 None None None 153004274 Common - glycosyl transferase family 2 Anae109_1408 223 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153005874 Common - aldo/keto reductase Anae109_3018 150 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 153005484 Nonpathogen - hypothetical protein Anae109_2624 2 None None None 153004857 Common - dehydrogenase complex catalytic domain Anae109_1995 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 153004428 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_1565 135 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153005815 Common - aminotransferase class V Anae109_2957 169 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 153006296 Nonpathogen - hypothetical protein Anae109_3453 1 None None None 153007083 Nonpathogen - hypothetical protein Anae109_4246 1 None None None 153005983 Common - Cellulose synthase (UDP-forming) Anae109_3128 59 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 153002941 Nonpathogen - sec-independent translocation protein mttA/Hcf106 Anae109_0062 2 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 153005766 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Anae109_2907 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 153003340 Common - Protein-glutamate O-methyltransferase Anae109_0466 150 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 153003053 Common - SNARE associated Golgi protein Anae109_0176 101 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 153005564 Common - glycosyl transferase group 1 Anae109_2704 99 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153006721 Common - cell division protein FtsW Anae109_3883 206 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 153006398 Common - protein kinase Anae109_3558 173 COG2319 COG2319, FOG: WD40 repeat General function prediction only 153006699 Common - biotin/lipoyl attachment domain-containing protein Anae109_3861 153 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 153006025 Common - AMP-dependent synthetase and ligase Anae109_3170 222 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 153005646 Nonpathogen - hypothetical protein Anae109_2787 3 COG1913 COG1913, Predicted Zn-dependent proteases General function prediction only 153005470 Common - cellulose biosynthesis (CelD)-like protein Anae109_2610 20 COG5653 COG5653, Protein involved in cellulose biosynthesis (CelD) Cell envelope biogenesis, outer membrane 153006165 Common - hypothetical protein Anae109_3322 50 COG3247 HdeD, Uncharacterized conserved protein Function unknown 153004216 Common - putative transposase Anae109_1349 54 None None None 153006451 Nonpathogen - hypothetical protein Anae109_3611 1 None None None 153004913 Common - hypothetical protein Anae109_2051 26 COG4412 COG4412, Uncharacterized protein conserved in bacteria Function unknown 153006053 Nonpathogen - HNH endonuclease Anae109_3198 4 COG1403 McrA, Restriction endonuclease Defense mechanisms 153003273 Common - metallophosphoesterase Anae109_0399 104 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 153003483 Common - acetylornithine deacetylase (ArgE) Anae109_0611 199 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 153007139 Common - Silent information regulator protein Sir2 Anae109_4302 140 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 153007328 Common - glutamate-1-semialdehyde-2,1-aminomutase Anae109_4491 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 153005585 Common - protein of unknown function DUF470 Anae109_2725 68 COG2898 COG2898, Uncharacterized conserved protein Function unknown 153006535 Nonpathogen - hypothetical protein Anae109_3697 4 None None None 153007010 Common - oxidoreductase FAD/NAD(P)-binding domain protein Anae109_4173 130 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 153005967 Nonpathogen - hypothetical protein Anae109_3112 2 None None None 153005949 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Anae109_3094 124 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 153003652 Common - hypothetical protein Anae109_0781 16 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 153004517 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Anae109_1654 54 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 153004957 Nonpathogen - NAD-dependent epimerase/dehydratase Anae109_2095 2 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153006704 Nonpathogen - sodium/hydrogen exchanger Anae109_3866 2 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 153004814 Common - signal transduction histidine kinase, nitrogen specific, NtrB Anae109_1952 223 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 153003941 Common - hypothetical protein Anae109_1074 6 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 153004879 Common - Amidohydrolase 3 Anae109_2017 103 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 153003127 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_0250 125 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153004254 Common - FAD dependent oxidoreductase Anae109_1388 152 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 153007144 Common - methyl-viologen-reducing hydrogenase delta subunit Anae109_4307 54 COG1908 FrhD, Coenzyme F420-reducing hydrogenase, delta subunit Energy production and conversion 153003206 Common - oligopeptide transporters, OPT superfamily Anae109_0332 38 COG1297 COG1297, Predicted membrane protein Function unknown 153007040 Common - UbiD family decarboxylase Anae109_4203 152 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 153006069 Nonpathogen - hypothetical protein Anae109_3215 11 COG4641 COG4641, Uncharacterized protein conserved in bacteria Function unknown 153004718 Nonpathogen - hypothetical protein Anae109_1856 2 None None None 153007245 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_4408 39 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153006151 Common - phage integrase family protein Anae109_3306 92 None None None 153004186 Common - Queuosine biosynthesis protein Anae109_1319 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 153004448 Common - ATP dependent DNA ligase Anae109_1585 74 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 153006111 Common - Methyltransferase type 11 Anae109_3259 63 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153005128 Nonpathogen - hypothetical protein Anae109_2267 4 None None None 153005534 Nonpathogen - hypothetical protein Anae109_2674 2 None None None 153006359 Nonpathogen - hypothetical protein Anae109_3519 2 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 153006861 Nonpathogen - hypothetical protein Anae109_4024 2 None None None 153007069 Nonpathogen - hypothetical protein Anae109_4232 1 None None None 153004539 Common - inner-membrane translocator Anae109_1676 130 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 153004022 Nonpathogen - hypothetical protein Anae109_1155 1 None None None 153005903 Common - formate dehydrogenase family accessory protein FdhD Anae109_3047 134 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 153004601 Common - DTW domain containing protein Anae109_1739 28 COG3148 COG3148, Uncharacterized conserved protein Function unknown 153003260 Common - penicillin-binding protein transpeptidase Anae109_0386 165 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 153006003 Nonpathogen - hypothetical protein Anae109_3148 1 None None None 153006579 Common - peptidase M23B Anae109_3741 187 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 153005413 Common - Ferredoxin-like protein Anae109_2553 93 COG3411 COG3411, Ferredoxin Energy production and conversion 153005348 Common - excinuclease ABC, C subunit Anae109_2488 224 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 153006261 Common - ATP-dependent protease La Anae109_3418 216 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 153006341 Common - Spore coat protein CotH Anae109_3499 11 COG5337 CotH, Spore coat assembly protein Cell envelope biogenesis, outer membrane 153004282 Nonpathogen - hypothetical protein Anae109_1416 4 None None None 153005745 Common - aldo/keto reductase Anae109_2886 204 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 153005134 Common - UBA/THIF-type NAD/FAD binding protein Anae109_2273 6 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 153003009 Nonpathogen - hypothetical protein Anae109_0132 2 COG5415 COG5415, Predicted integral membrane metal-binding protein General function prediction only 153003790 Common - Methylated-DNA-(protein)-cysteine S-methyltransferase DNA binding Anae109_0922 46 COG3695 COG3695, Predicted methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 153004404 Nonpathogen - putative transcriptional regulator Anae109_1539 7 COG2345 COG2345, Predicted transcriptional regulator Transcription 153005464 Common - succinate dehydrogenase and fumarate reductase iron-sulfur protein Anae109_2604 64 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 153005172 Common - acetyl-CoA carboxylase, carboxyl transferase, alpha subunit Anae109_2311 190 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 153005856 Common - Glutamate dehydrogenase (NADP(+)) Anae109_3000 167 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 153007121 Nonpathogen - SNARE associated Golgi protein Anae109_4284 7 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 153005079 Common - putative transcriptional regulator, CopG family Anae109_2218 66 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 153004494 Common - ABC transporter related Anae109_1631 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 153006863 Common - glycosyltransferase 36 Anae109_4026 47 COG3459 COG3459, Cellobiose phosphorylase Carbohydrate transport and metabolism 153004725 Nonpathogen - response regulator receiver protein Anae109_1863 5 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153005382 Common - glycine cleavage system T protein Anae109_2522 179 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 153006944 Nonpathogen - hypothetical protein Anae109_4107 16 None None None 153006925 Nonpathogen - protein of unknown function DUF169 Anae109_4088 24 COG2043 COG2043, Uncharacterized protein conserved in archaea Function unknown 153003611 Common - putative ribonuclease BN Anae109_0739 128 COG1295 Rbn, Predicted membrane protein Function unknown 153003151 Common - 2-nitropropane dioxygenase NPD Anae109_0274 92 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 153003337 Common - UDP-N-acetylglucosamine pyrophosphorylase Anae109_0463 230 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 153004192 Common - Auxin Efflux Carrier Anae109_1325 14 COG0679 COG0679, Predicted permeases General function prediction only 153003645 Common - AAA ATPase central domain protein Anae109_0774 222 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 153004905 Common - ATP-dependent metalloprotease FtsH Anae109_2043 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 153003980 Common - protein kinase Anae109_1113 155 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153006744 Nonpathogen - hypothetical protein Anae109_3906 1 None None None 153007251 Common - inner-membrane translocator Anae109_4414 148 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 153006318 Common - protein of unknown function DUF201 Anae109_3475 44 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 153004823 Nonpathogen - hypothetical protein Anae109_1961 1 None None None 153004343 Common - valyl-tRNA synthetase Anae109_1477 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153004530 Common - UBA/THIF-type NAD/FAD binding protein Anae109_1667 207 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 153003778 Common - hypothetical protein Anae109_0910 8 COG3652 COG3652, Predicted outer membrane protein Function unknown 153005233 Nonpathogen - hypothetical protein Anae109_2372 2 None None None 153005070 Nonpathogen - hypothetical protein Anae109_2209 2 None None None 153002991 Nonpathogen - hypothetical protein Anae109_0114 1 None None None 153004926 Common - putative methyltransferase Anae109_2064 203 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 153005116 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Anae109_2255 4 None None None 153006985 Common - Hsp33 protein Anae109_4148 96 COG1281 COG1281, Disulfide bond chaperones of the HSP33 family Posttranslational modification, protein turnover, chaperones 153007031 Common - Polyprenyl synthetase Anae109_4194 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 153005256 Common - Patatin Anae109_2395 52 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 153004074 Nonpathogen - hypothetical protein Anae109_1207 1 None None None 153005211 Common - RNA modification enzyme, MiaB family Anae109_2350 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 153003407 Nonpathogen - hypothetical protein Anae109_0534 1 None None None 153005592 Common - ATP-cone domain protein Anae109_2732 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 153005666 Nonpathogen - Glyoxalase/bleomycin resistance protein/dioxygenase Anae109_2807 14 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 153004487 Common - hypothetical protein Anae109_1624 6 None None None 153004546 Common - metallophosphoesterase Anae109_1683 10 COG1409 Icc, Predicted phosphohydrolases General function prediction only 153006686 Common - putative nitric-oxide reductase Anae109_3848 72 COG3256 NorB, Nitric oxide reductase large subunit Inorganic ion transport and metabolism 153002975 Common - beta-lactamase domain protein Anae109_0096 160 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 153006232 Common - hypothetical protein Anae109_3389 4 None None None 153006547 Common - DNA replication protein-like protein Anae109_3709 47 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 153003736 Common - Cupin 2 conserved barrel domain protein Anae109_0866 29 COG3837 COG3837, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 153004119 Common - aconitate hydratase 2 Anae109_1252 215 COG1049 AcnB, Aconitase B Energy production and conversion 153005576 Common - MazG family protein Anae109_2716 156 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 153003917 Nonpathogen - hypothetical protein Anae109_1049 2 None None None 153002998 Common - ribosomal protein S18 Anae109_0121 212 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 153003712 Common - Polysulphide reductase NrfD Anae109_0842 41 COG5557 COG5557, Polysulphide reductase Energy production and conversion 153002985 Common - Stress responsive alpha-beta barrel domain protein Anae109_0108 33 None None None 153003333 Common - PHP domain protein Anae109_0459 80 COG1796 POL4, DNA polymerase IV (family X) DNA replication, recombination, and repair 153005510 Common - HNH endonuclease Anae109_2650 26 COG1403 McrA, Restriction endonuclease Defense mechanisms 153004991 Common - Mg2 transporter protein CorA family protein Anae109_2129 148 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 153005207 Common - acyl-CoA hydrolase Anae109_2346 19 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 153004153 Common - NADH dehydrogenase (quinone) Anae109_1286 191 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 153005294 Nonpathogen - putative transcriptional regulator, Crp/Fnr family Anae109_2434 3 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 153005344 Nonpathogen - hypothetical protein Anae109_2484 1 None None None 153005570 Nonpathogen - CopG domain protein DNA-binding domain protein Anae109_2710 1 None None None 153003297 Common - putative phosphohistidine phosphatase, SixA Anae109_0423 53 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 153005398 Common - protein of unknown function DUF444 Anae109_2538 71 COG2718 COG2718, Uncharacterized conserved protein Function unknown 153005000 Common - acetate kinase Anae109_2138 163 COG3957 COG3957, Phosphoketolase Carbohydrate transport and metabolism 153005111 Common - small GTP-binding protein Anae109_2250 173 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 153004850 Common - methylmalonyl-CoA mutase, large subunit Anae109_1988 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 153006814 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_3977 85 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153005179 Nonpathogen - protein of unknown function DUF99 Anae109_2318 14 COG1628 COG1628, Uncharacterized conserved protein Function unknown 153003198 Common - aminotransferase class I and II Anae109_0323 222 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 153003860 Common - crossover junction endodeoxyribonuclease RuvC Anae109_0992 193 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 153006921 Common - NAD-dependent epimerase/dehydratase Anae109_4084 176 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153003290 Common - PAS/PAC sensor signal transduction histidine kinase Anae109_0416 220 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 153003442 Common - efflux transporter, RND family, MFP subunit Anae109_0569 151 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153007321 Common - GTP-binding protein YchF Anae109_4484 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 153006856 Nonpathogen - hypothetical protein Anae109_4019 1 None None None 153005292 Common - molybdopterin-guanine dinucleotide biosynthesis protein B Anae109_2432 75 COG1763 MobB, Molybdopterin-guanine dinucleotide biosynthesis protein Coenzyme metabolism 153006407 Common - alpha/beta hydrolase fold Anae109_3567 59 COG1647 COG1647, Esterase/lipase General function prediction only 153003657 Common - oxidoreductase FAD/NAD(P)-binding domain protein Anae109_0786 76 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 153004416 Common - hypothetical protein Anae109_1552 20 None None None 153006320 Nonpathogen - hypothetical protein Anae109_3477 1 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 153007273 Common - glycosyl transferase group 1 Anae109_4436 214 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153003495 Common - putative DeoR-family transcriptional regulator Anae109_0623 41 COG2378 COG2378, Predicted transcriptional regulator Transcription 153005770 Common - biotin/lipoyl attachment domain-containing protein Anae109_2911 32 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 153006942 Common - ferrous iron transport protein B Anae109_4105 209 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 153003577 Common - Biopolymer transport protein ExbD/TolR Anae109_0705 136 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 153004664 Common - glycine cleavage H-protein Anae109_1802 147 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 153002954 Common - thiamine-phosphate pyrophosphorylase Anae109_0075 109 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 153003090 Common - putative regulatory protein, FmdB family Anae109_0213 65 COG2331 COG2331, Uncharacterized protein conserved in bacteria Function unknown 153003372 Common - hypothetical protein Anae109_0499 3 None None None 153006662 Common - putative CBS domain and cyclic nucleotide-regulated nucleotidyltransferase Anae109_3824 109 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 153004862 Nonpathogen - hypothetical protein Anae109_2000 1 None None None 153003130 Common - teichoic acid biosynthesis related protein Anae109_0253 23 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 153005065 Common - thioredoxin Anae109_2204 232 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 153003534 Common - pyrimidine-nucleoside phosphorylase Anae109_0662 122 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 153005377 Common - Adenosine deaminase Anae109_2517 104 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 153006636 Common - Citrate (Si)-synthase Anae109_3798 190 COG0372 GltA, Citrate synthase Energy production and conversion 153002918 Common - Phenylacetate--CoA ligase Anae109_0039 120 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 153004559 Common - binding-protein-dependent transport systems inner membrane component Anae109_1696 139 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 153003635 Common - ribonuclease H Anae109_0764 41 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 153006830 Common - type III restriction protein res subunit Anae109_3993 138 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 153004188 Common - queuine tRNA-ribosyltransferase Anae109_1321 228 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 153003923 Common - oxidoreductase molybdopterin binding Anae109_1055 87 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 153002972 Common - Methyltransferase type 12 Anae109_0093 7 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 153004650 Common - efflux transporter, RND family, MFP subunit Anae109_1788 116 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153004208 Common - helicase domain protein Anae109_1341 223 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 153004951 Nonpathogen - hypothetical protein Anae109_2089 1 None None None 153003484 Common - formiminoglutamate deiminase Anae109_0612 113 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 153004602 Nonpathogen - hypothetical protein Anae109_1740 1 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 153006840 Common - hypothetical protein Anae109_4003 8 None None None 153005057 Common - signal peptidase I Anae109_2196 198 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 153003956 Common - thiamine pyrophosphate protein central region Anae109_1089 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 153006990 Nonpathogen - response regulator receiver protein Anae109_4153 1 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153006177 Nonpathogen - hypothetical protein Anae109_3334 1 None None None 153006196 Nonpathogen - hypothetical protein Anae109_3353 1 None None None 153004895 Common - short-chain dehydrogenase/reductase SDR Anae109_2033 232 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153003057 Common - N-acetyl-gamma-glutamyl-phosphate reductase Anae109_0180 209 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 153003052 Common - integral membrane protein-like protein Anae109_0175 3 COG5650 COG5650, Predicted integral membrane protein Function unknown 153005920 Common - Alcohol dehydrogenase GroES domain protein Anae109_3065 212 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 153004191 Common - protein-export membrane protein SecF Anae109_1324 208 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 153003014 Common - major facilitator superfamily MFS_1 Anae109_0137 148 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153003558 Common - type IV pilus assembly protein PilM Anae109_0686 94 COG4972 PilM, Tfp pilus assembly protein, ATPase PilM Cell motility and secretion / Intracellular trafficking and secretion 153004031 Nonpathogen - hypothetical protein Anae109_1164 2 None None None 153005677 Common - 5'-3' exonuclease Anae109_2818 216 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 153004805 Common - 16S rRNA processing protein RimM Anae109_1943 44 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 153006231 Common - hypothetical protein Anae109_3388 4 None None None 153004786 Common - ribosomal protein S14 Anae109_1924 186 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 153003426 Common - protein of unknown function DUF112 transmembrane Anae109_0553 75 COG3333 COG3333, Uncharacterized protein conserved in bacteria Function unknown 153004067 Common - channel protein, hemolysin III family Anae109_1200 116 COG1272 COG1272, Predicted membrane protein, hemolysin III homolog General function prediction only 153004553 Nonpathogen - outer membrane efflux protein Anae109_1690 2 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 153006918 Common - amine oxidase Anae109_4081 43 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 153006331 Nonpathogen - hypothetical protein Anae109_3489 2 None None None 153002936 Common - putative mRNA 3'-end processing factor Anae109_0057 81 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 153005730 Common - hypothetical protein Anae109_2871 12 None None None 153003472 Common - 6-phosphogluconolactonase Anae109_0599 115 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 153004618 Nonpathogen - aldo/keto reductase Anae109_1756 6 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 153003326 Common - MOFRL domain protein Anae109_0452 84 COG2379 GckA, Putative glycerate kinase Carbohydrate transport and metabolism 153005614 Common - ABC transporter related Anae109_2755 224 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 153003227 Common - diaminopimelate decarboxylase Anae109_0353 218 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 153003045 Common - TonB family protein Anae109_0168 22 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 153004598 Common - Tetratricopeptide TPR_2 repeat protein Anae109_1736 19 None None None 153005282 Common - hypothetical protein Anae109_2422 65 COG4301 COG4301, Uncharacterized conserved protein Function unknown 153005991 Nonpathogen - hypothetical protein Anae109_3136 2 None None None 153004466 Common - response regulator receiver protein Anae109_1603 212 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 153005530 Common - Endonuclease/exonuclease/phosphatase Anae109_2670 82 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 153004520 Nonpathogen - hypothetical protein Anae109_1657 1 None None None 153006104 Common - OsmC family protein Anae109_3252 88 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 153006767 Common - hypothetical protein Anae109_3929 14 None None None 153003482 Common - type III restriction protein res subunit Anae109_0610 121 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 153004815 Common - Lytic transglycosylase catalytic Anae109_1953 146 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 153003251 Common - aspartate 1-decarboxylase Anae109_0377 130 COG0853 PanD, Aspartate 1-decarboxylase Coenzyme metabolism 153003888 Common - transcriptional regulator, TetR family Anae109_1020 63 COG1309 AcrR, Transcriptional regulator Transcription 153006703 Common - pyridoxal-phosphate dependent TrpB-like enzyme Anae109_3865 225 COG1350 COG1350, Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) General function prediction only 153005897 Common - putative formate dehydrogenase formation protein Anae109_3041 38 COG3058 FdhE, Uncharacterized protein involved in formate dehydrogenase formation Posttranslational modification, protein turnover, chaperones 153006515 Nonpathogen - hypothetical protein Anae109_3676 2 None None None 153005476 Common - lipopolysaccharide biosynthesis protein Anae109_2616 29 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 153006760 Nonpathogen - hypothetical protein Anae109_3922 1 None None None 153004255 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Anae109_1389 49 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 153004436 Common - molybdate ABC transporter, inner membrane subunit Anae109_1573 225 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 153003049 Common - hypothetical protein Anae109_0172 10 None None None 153005362 Nonpathogen - hypothetical protein Anae109_2502 1 None None None 153006907 Common - superoxide dismutase copper/zinc binding Anae109_4070 87 COG2032 SodC, Cu/Zn superoxide dismutase Inorganic ion transport and metabolism 153004799 Common - RNA-binding S4 domain protein Anae109_1937 241 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 153003307 Common - ABC transporter related Anae109_0433 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 153003267 Nonpathogen - hypothetical protein Anae109_0393 4 None None None 153006214 Common - MJ0042 family finger-like protein Anae109_3371 4 COG5373 COG5373, Predicted membrane protein Function unknown 153004364 Common - GAF sensor signal transduction histidine kinase Anae109_1498 219 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 153005979 Common - outer membrane efflux protein Anae109_3124 18 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 153005264 Nonpathogen - acyltransferase family protein Anae109_2404 2 COG3503 COG3503, Predicted membrane protein Function unknown 153004495 Common - HNH endonuclease Anae109_1632 4 COG1403 McrA, Restriction endonuclease Defense mechanisms 153007297 Common - CheC, inhibitor of MCP methylation Anae109_4460 18 COG1776 CheC, Chemotaxis protein CheC, inhibitor of MCP methylation Cell motility and secretion / Signal transduction mechanisms 153003341 Common - response regulator receiver protein Anae109_0467 224 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 153004580 Nonpathogen - hypothetical protein Anae109_1717 1 None None None 153004127 Nonpathogen - hypothetical protein Anae109_1260 2 None None None 153006141 Common - hypothetical protein Anae109_3293 25 COG4898 COG4898, Uncharacterized protein conserved in bacteria Function unknown 153007007 Common - hypothetical protein Anae109_4170 4 None None None 153004677 Common - Methyltransferase type 11 Anae109_1815 27 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153005495 Common - polysaccharide biosynthesis protein CapD Anae109_2635 191 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153006485 Nonpathogen - cytochrome c biogenesis protein transmembrane region Anae109_3646 1 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 153003411 Common - Spore coat U domain protein Anae109_0538 5 COG5430 COG5430, Uncharacterized secreted protein Function unknown 153002940 Common - protein of unknown function DUF55 Anae109_0061 94 COG2947 COG2947, Uncharacterized conserved protein Function unknown 153005123 Nonpathogen - cobalamin biosynthesis protein CbiD Anae109_2262 1 None None None 153003612 Common - histone family protein DNA-binding protein Anae109_0740 197 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 153003350 Common - 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase Anae109_0476 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 153004674 Nonpathogen - hypothetical protein Anae109_1812 4 None None None 153005329 Nonpathogen - hypothetical protein Anae109_2469 2 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 153006833 Common - ExsB family protein Anae109_3996 95 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 153007197 Common - hypothetical protein Anae109_4360 3 None None None 153003149 Nonpathogen - hypothetical protein Anae109_0272 1 COG4244 COG4244, Predicted membrane protein Function unknown 153004094 Common - Endonuclease/exonuclease/phosphatase Anae109_1227 26 COG3021 COG3021, Uncharacterized protein conserved in bacteria Function unknown 153004956 Common - protein kinase Anae109_2094 155 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153003803 Common - band 7 protein Anae109_0935 217 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 153005551 Common - gid protein Anae109_2691 81 COG1206 Gid, NAD(FAD)-utilizing enzyme possibly involved in translation Translation, ribosomal structure and biogenesis 153005158 Common - CheA signal transduction histidine kinase Anae109_2297 219 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 153005317 Nonpathogen - hypothetical protein Anae109_2457 1 None None None 153004079 Common - AMP-dependent synthetase and ligase Anae109_1212 220 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 153006181 Nonpathogen - hypothetical protein Anae109_3338 1 None None None 153005080 Common - RNA polymerase, sigma 32 subunit, RpoH Anae109_2219 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 153005869 Common - putative heat-shock chaperone protein Anae109_3013 85 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 153006219 Nonpathogen - hypothetical protein Anae109_3376 2 None None None 153006984 Nonpathogen - hypothetical protein Anae109_4147 1 None None None 153003020 Common - glycine oxidase ThiO Anae109_0143 167 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 153003566 Common - acetyl-CoA carboxylase, biotin carboxyl carrier protein Anae109_0694 179 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 153003062 Nonpathogen - SNARE associated Golgi protein Anae109_0185 1 COG1238 COG1238, Predicted membrane protein Function unknown 153003241 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Anae109_0367 157 COG2876 AroA, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 153005902 Common - putative PAS/PAC sensor protein Anae109_3046 54 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 153004756 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Anae109_1894 110 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 153004869 Common - molybdopterin oxidoreductase Fe4S4 region Anae109_2007 167 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 153004779 Common - ribosomal protein S3 Anae109_1917 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 153006206 Nonpathogen - Disintegrin Anae109_3363 3 None None None 153004062 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Anae109_1195 126 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 153006785 Common - Cobyrinic acid ac-diamide synthase Anae109_3948 199 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 153005746 Nonpathogen - hypothetical protein Anae109_2887 1 None None None 153005522 Nonpathogen - hypothetical protein Anae109_2662 1 None None None 153003968 Common - filamentation induced by cAMP protein Fic Anae109_1101 35 COG3177 COG3177, Uncharacterized conserved protein Function unknown 153004201 Nonpathogen - hypothetical protein Anae109_1334 1 None None None 153005007 Nonpathogen - hypothetical protein Anae109_2146 1 None None None 153005166 Common - cobalamin (vitamin B12) biosynthesis CbiM protein Anae109_2305 53 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 153005556 Nonpathogen - hypothetical protein Anae109_2696 1 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 153004695 Common - lipoprotein, putative Anae109_1833 9 COG4380 COG4380, Uncharacterized protein conserved in bacteria Function unknown 153006536 Nonpathogen - Fibronectin type III domain protein Anae109_3698 2 None None None 153004387 Common - DedA Anae109_1522 95 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 153005276 Nonpathogen - major facilitator superfamily MFS_1 Anae109_2416 1 None None None 153006736 Common - hemerythrin-like metal-binding protein Anae109_3898 40 COG2703 COG2703, Hemerythrin Inorganic ion transport and metabolism 153004454 Common - acetate kinase Anae109_1591 161 COG0282 ackA, Acetate kinase Energy production and conversion 153006720 Common - UDP-N-acetylmuramoylalanine--D-glutamate ligase Anae109_3882 210 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 153005503 Nonpathogen - hypothetical protein Anae109_2643 1 None None None 153003230 Common - 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase Anae109_0356 180 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 153004706 Nonpathogen - hypothetical protein Anae109_1844 1 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 153005303 Common - Radical SAM domain protein Anae109_2443 14 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 153005107 Common - hypothetical protein Anae109_2246 9 None None None 153006817 Common - phage integrase family protein Anae109_3980 128 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 153006038 Nonpathogen - hypothetical protein Anae109_3183 1 None None None 153005406 Nonpathogen - membrane protein Anae109_2546 1 None None None 153005797 Nonpathogen - hypothetical protein Anae109_2938 1 None None None 153004161 Common - ferredoxin Anae109_1294 184 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 153002955 Common - peptidase C26 Anae109_0076 121 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 153004562 Common - Pyridoxal 5'-phosphate synthase Anae109_1699 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 153005424 Common - H+transporting two-sector ATPase alpha/beta subunit central region Anae109_2564 247 COG1155 NtpA, Archaeal/vacuolar-type H+-ATPase subunit A Energy production and conversion 153004752 Common - FAD linked oxidase domain protein Anae109_1890 201 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 153004136 Common - Abortive infection protein Anae109_1269 5 None None None 153004569 Nonpathogen - NAD-dependent epimerase/dehydratase Anae109_1706 5 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153005719 Nonpathogen - cytochrome c oxidase subunit III Anae109_2860 1 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 153004881 Nonpathogen - hypothetical protein Anae109_2019 1 None None None 153003212 Common - hypothetical protein Anae109_0338 7 None None None 153005586 Nonpathogen - peptidase M17 leucyl aminopeptidase domain protein Anae109_2726 2 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 153006492 Common - phosphodiesterase, MJ0936 family Anae109_3653 87 COG0622 COG0622, Predicted phosphoesterase General function prediction only 153005087 Common - NusG antitermination factor Anae109_2226 215 COG0250 NusG, Transcription antiterminator Transcription 153006793 Common - response regulator receiver protein Anae109_3956 223 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153003530 Common - response regulator receiver modulated CheB methylesterase Anae109_0658 181 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 153005838 Common - transcriptional regulator, TetR family Anae109_2980 100 COG1309 AcrR, Transcriptional regulator Transcription 153004961 Nonpathogen - hypothetical protein Anae109_2099 1 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153003535 Common - inosine guanosine and xanthosine phosphorylase family Anae109_0663 139 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 153003588 Common - glycosyl transferase family 2 Anae109_0716 150 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 153006252 Nonpathogen - hypothetical protein Anae109_3409 3 None None None 153004396 Common - Sterol-binding domain protein Anae109_1531 13 COG3255 COG3255, Putative sterol carrier protein Lipid metabolism 153006462 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_3622 51 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153003775 Common - SUF system FeS assembly protein, NifU family Anae109_0907 150 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 153005429 Common - V-type ATPase 116 kDa subunit Anae109_2569 32 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 153005453 Common - cytochrome c family protein Anae109_2593 21 None None None 153003784 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Anae109_0916 17 COG0748 HugZ, Putative heme iron utilization protein Inorganic ion transport and metabolism 153006826 Common - helicase domain protein Anae109_3989 149 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 153003704 Common - methyl-accepting chemotaxis sensory transducer Anae109_0834 82 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153005678 Common - Quinone oxidoreductase putative YhdH/YhfP Anae109_2819 139 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 153005305 Common - Nicotinamidase Anae109_2445 83 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 153005931 Common - FAD dependent oxidoreductase Anae109_3076 43 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 153006727 Common - hypothetical protein Anae109_3889 4 None None None 153004246 Nonpathogen - hypothetical protein Anae109_1380 2 None None None 153007153 Common - 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family Anae109_4316 96 COG1778 COG1778, Low specificity phosphatase (HAD superfamily) General function prediction only 153005703 Nonpathogen - hypothetical protein Anae109_2844 6 None None None 153006586 Common - hypothetical protein Anae109_3748 104 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 153005565 Common - twitching motility protein Anae109_2705 222 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 153005199 Common - ATP-dependent metalloprotease FtsH Anae109_2338 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 153004046 Common - acyl-CoA dehydrogenase domain protein Anae109_1179 164 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 153003823 Common - Nitrite reductase (cytochrome; ammonia-forming) Anae109_0955 40 COG3303 NrfA, Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit Inorganic ion transport and metabolism 153004935 Common - transcription elongation factor GreA Anae109_2073 204 COG0782 GreA, Transcription elongation factor Transcription 153006692 Common - tRNA synthetase class II (D K and N) Anae109_3854 200 COG2269 COG2269, Truncated, possibly inactive, lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 153006601 Common - CMP/dCMP deaminase zinc-binding Anae109_3763 214 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 153004034 Common - phospholipase D/Transphosphatidylase Anae109_1167 139 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 153006508 Common - alpha/beta hydrolase fold Anae109_3669 143 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153003697 Common - hypothetical protein Anae109_0827 26 None None None 153006288 Nonpathogen - hypothetical protein Anae109_3445 1 None None None 153005372 Common - phosphoribosylformylglycinamidine cyclo-ligase Anae109_2512 227 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 153004295 Common - peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin Anae109_1429 22 COG1876 VanY, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 153005027 Common - pyruvate carboxyltransferase Anae109_2166 187 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 153003458 Nonpathogen - hypothetical protein Anae109_0585 1 None None None 153002965 Common - sigma54 specific transcriptional regulator, Fis family Anae109_0086 175 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 153005019 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Anae109_2158 174 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 153003441 Common - transporter, hydrophobe/amphiphile efflux-1 (HAE1) family Anae109_0568 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 153004745 Common - phenylalanyl-tRNA synthetase, alpha subunit Anae109_1883 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 153003828 Nonpathogen - hypothetical protein Anae109_0960 1 None None None 153003261 Nonpathogen - hypothetical protein Anae109_0387 4 None None None 153003745 Common - peptidase C14 caspase catalytic subunit p20 Anae109_0877 9 None None None 153003914 Common - transcriptional regulator, TetR family Anae109_1046 75 COG1309 AcrR, Transcriptional regulator Transcription 153003974 Nonpathogen - glycosyl transferase group 1 Anae109_1107 11 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153003358 Common - regulatory protein ArsR Anae109_0484 93 COG0640 ArsR, Predicted transcriptional regulators Transcription 153003238 Common - putative transaldolase Anae109_0364 154 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 153003902 Common - flavin reductase domain protein FMN-binding Anae109_1034 99 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 153004014 Common - deoxyuridine 5'-triphosphate nucleotidohydrolase Dut Anae109_1147 183 COG0756 Dut, dUTPase Nucleotide transport and metabolism 153005826 Common - trehalose synthase Anae109_2968 174 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 153003469 Common - 6-phosphogluconate dehydrogenase, decarboxylating Anae109_0596 185 COG1023 Gnd, Predicted 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 153007261 Nonpathogen - hypothetical protein Anae109_4424 6 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 153003145 Common - protein of unknown function DUF558 Anae109_0268 104 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 153004267 Common - phosphoribosylaminoimidazole carboxylase, catalytic subunit Anae109_1401 228 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 153005910 Nonpathogen - protein of unknown function DUF1469 Anae109_3054 1 None None None 153005822 Nonpathogen - hypothetical protein Anae109_2964 7 None None None 153005796 Common - protein of unknown function DUF399 Anae109_2937 32 COG3016 PhuW, Uncharacterized iron-regulated protein Function unknown 153006626 Common - GCN5-related N-acetyltransferase Anae109_3788 46 COG0456 RimI, Acetyltransferases General function prediction only 153006004 Nonpathogen - hypothetical protein Anae109_3149 3 None None None 153003192 Common - malto-oligosyltrehalose synthase Anae109_0317 109 COG3280 TreY, Maltooligosyl trehalose synthase Carbohydrate transport and metabolism 153007137 Common - alkylhydroperoxidase like protein, AhpD family Anae109_4300 13 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 153006663 Common - putative CBS domain and cyclic nucleotide-regulated nucleotidyltransferase Anae109_3825 111 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 153005651 Common - UspA domain protein Anae109_2792 139 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 153007174 Nonpathogen - hypothetical protein Anae109_4337 1 None None None 153003833 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_0965 213 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153005848 Common - rhodanese-like domain protein Anae109_2992 15 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 153006259 Common - two component transcriptional regulator, LytTR family Anae109_3416 149 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 153004781 Nonpathogen - ribosomal protein L29 Anae109_1919 1 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 153006598 Common - recombination protein RecR Anae109_3760 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 153006938 Nonpathogen - Methyltransferase type 11 Anae109_4101 7 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 153003385 Common - regulatory protein ArsR Anae109_0512 26 COG0640 ArsR, Predicted transcriptional regulators Transcription 153004050 Common - protein kinase Anae109_1183 136 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153004659 Nonpathogen - peptidase zinc-dependent Anae109_1797 30 COG1913 COG1913, Predicted Zn-dependent proteases General function prediction only 153006070 Common - NAD-dependent epimerase/dehydratase Anae109_3216 231 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153006224 Common - methylthioadenosine phosphorylase Anae109_3381 138 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 153005449 Common - lipid-A-disaccharide synthase Anae109_2589 139 COG0763 LpxB, Lipid A disaccharide synthetase Cell envelope biogenesis, outer membrane 153007106 Common - dihydroxy-acid dehydratase Anae109_4269 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 153006077 Nonpathogen - hypothetical protein Anae109_3223 10 COG3664 XynB, Beta-xylosidase Carbohydrate transport and metabolism 153004594 Common - Diphosphate--fructose-6-phosphate 1-phosphotransferase Anae109_1732 154 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 153003113 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Anae109_0236 124 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 153005327 Common - Radical SAM domain protein Anae109_2467 178 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 153003028 Common - HPr kinase Anae109_0151 59 COG1493 HprK, Serine kinase of the HPr protein, regulates carbohydrate metabolism Signal transduction mechanisms 153006999 Common - 3-hydroxyacyl-CoA dehydrogenase NAD-binding Anae109_4162 181 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 153005712 Common - putative lipoprotein Anae109_2853 17 None None None 153006393 Nonpathogen - hypothetical protein Anae109_3553 1 None None None 153003279 Common - amino acid/peptide transporter Anae109_0405 79 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 153007056 Common - phage integrase family protein Anae109_4219 84 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 153006640 Common - malto-oligosyltrehalose trehalohydrolase Anae109_3802 153 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 153007221 Common - peptidase M24 Anae109_4384 159 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 153003960 Common - ribosomal RNA methyltransferase RrmJ/FtsJ Anae109_1093 138 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 153006775 Nonpathogen - DNA repair protein RadC Anae109_3938 6 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 153003517 Common - Protein-glutamate O-methyltransferase Anae109_0645 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 153005543 Common - 2-alkenal reductase Anae109_2683 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 153006558 Common - hypothetical protein Anae109_3720 6 None None None 153003272 Nonpathogen - hypothetical protein Anae109_0398 13 COG4932 COG4932, Predicted outer membrane protein Cell envelope biogenesis, outer membrane 153006438 Common - nitrite transporter Anae109_3598 79 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 153005320 Common - glycyl-tRNA synthetase, alpha subunit Anae109_2460 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 153006094 Common - transcriptional regulator, TetR family Anae109_3241 65 COG1309 AcrR, Transcriptional regulator Transcription 153005483 Common - protein of unknown function DUF201 Anae109_2623 26 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 153003306 Nonpathogen - major facilitator superfamily transporter Anae109_0432 1 None None None 153005784 Common - hypothetical protein Anae109_2925 100 None None None 153003522 Common - response regulator receiver protein Anae109_0650 225 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153006893 Nonpathogen - hypothetical protein Anae109_4056 1 None None None 153004029 Common - AMMECR1 domain protein Anae109_1162 78 COG2078 AMMECR1, Uncharacterized conserved protein Function unknown 153005334 Common - chaperone DnaJ domain protein Anae109_2474 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 153004455 Common - alpha/beta hydrolase fold Anae109_1592 77 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153005953 Common - 4-oxalocrotonate tautomerase family enzyme Anae109_3098 33 COG1942 COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog General function prediction only 153007282 Nonpathogen - hypothetical protein Anae109_4445 4 COG1503 eRF1, Peptide chain release factor 1 (eRF1) Translation, ribosomal structure and biogenesis 153006853 Common - transcriptional regulator-like protein Anae109_4016 32 COG2378 COG2378, Predicted transcriptional regulator Transcription 153007071 Nonpathogen - hypothetical protein Anae109_4234 1 None None None 153003763 Common - ABC-2 type transporter Anae109_0895 114 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 153006658 Common - major facilitator superfamily MFS_1 Anae109_3820 45 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153007180 Common - protein of unknown function DUF205 Anae109_4343 170 COG0344 COG0344, Predicted membrane protein Function unknown 153003276 Common - protein of unknown function DUF423 Anae109_0402 52 COG2363 COG2363, Uncharacterized small membrane protein Function unknown 153005625 Common - Cytochrome-c peroxidase Anae109_2766 96 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 153004906 Nonpathogen - hypothetical protein Anae109_2044 2 None None None 153006569 Common - hypothetical protein Anae109_3731 7 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 153006453 Common - Bile acid:sodium symporter Anae109_3613 77 COG0385 COG0385, Predicted Na+-dependent transporter General function prediction only 153003951 Common - restriction endonuclease Anae109_1084 45 COG1715 Mrr, Restriction endonuclease Defense mechanisms 153006947 Common - molybdopterin oxidoreductase Anae109_4110 184 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 153004667 Common - cytochrome C family protein Anae109_1805 20 None None None 153006930 Common - Propionyl-CoA carboxylase Anae109_4093 146 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 153004770 Common - ribosomal protein S7 Anae109_1908 248 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 153006948 Common - membrane protein involved in aromatic hydrocarbon degradation Anae109_4111 53 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 153003644 Common - protein of unknown function UPF0227 Anae109_0773 11 COG3150 COG3150, Predicted esterase General function prediction only 153004243 Common - hypothetical protein Anae109_1377 3 None None None 153006939 Nonpathogen - hypothetical protein Anae109_4102 1 None None None 153004834 Common - peptidase M16 domain protein Anae109_1972 189 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 153005891 Common - protease-associated PA domain protein Anae109_3035 56 COG3227 LasB, Zinc metalloprotease (elastase) Amino acid transport and metabolism 153003134 Common - phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent Anae109_0257 125 COG0696 GpmI, Phosphoglyceromutase Carbohydrate transport and metabolism 153004017 Common - BioH protein, putative Anae109_1150 3 COG2267 PldB, Lysophospholipase Lipid metabolism 153006552 Common - chaperonin Cpn10 Anae109_3714 216 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 153006926 Common - lipid A biosynthesis acyltransferase Anae109_4089 126 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 153003759 Common - outer membrane efflux protein Anae109_0891 6 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 153007032 Nonpathogen - permease YjgP/YjgQ family protein Anae109_4195 11 COG0795 COG0795, Predicted permeases General function prediction only 153007302 Common - thiamine-monophosphate kinase Anae109_4465 188 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 153004978 Common - Sua5/YciO/YrdC/YwlC family protein Anae109_2116 237 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 153005760 Nonpathogen - hypothetical protein Anae109_2901 2 None None None 153007254 Common - response regulator receiver protein Anae109_4417 194 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153005731 Nonpathogen - hypothetical protein Anae109_2872 1 None None None 153003631 Common - GatB/Yqey domain protein Anae109_0760 152 COG1610 COG1610, Uncharacterized conserved protein Function unknown 153004410 Common - hypothetical protein Anae109_1546 5 None None None 153006154 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Anae109_3310 97 COG0546 Gph, Predicted phosphatases General function prediction only 153003661 Common - stationary-phase survival protein SurE Anae109_0790 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 153004118 Common - Non-specific protein-tyrosine kinase Anae109_1251 124 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 153003322 Common - NusB/RsmB/TIM44 Anae109_0448 201 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 153003735 Common - Redoxin domain protein Anae109_0865 107 COG2077 Tpx, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 153003869 Common - UDP-3-0-acyl N-acetylglucosamine deacetylase Anae109_1001 139 COG0774 LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase Cell envelope biogenesis, outer membrane 153003576 Common - TonB family protein Anae109_0704 4 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 153002977 Common - UvrD/REP helicase Anae109_0098 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 153003184 Common - protein of unknown function DUF344 Anae109_0309 127 COG2326 COG2326, Uncharacterized conserved protein Function unknown 153003682 Common - protein of unknown function DUF224 cysteine-rich region domain protein Anae109_0812 151 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 153005900 Common - molybdopterin oxidoreductase Fe4S4 region Anae109_3044 175 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 153005399 Common - SpoVR family protein Anae109_2539 71 COG2719 SpoVR, Uncharacterized conserved protein Function unknown 153003382 Common - hypothetical protein Anae109_0509 25 COG3875 COG3875, Uncharacterized conserved protein Function unknown 153007202 Common - PAS/PAC sensor signal transduction histidine kinase Anae109_4365 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153004626 Nonpathogen - hemerythrin-like metal-binding protein Anae109_1764 9 COG2703 COG2703, Hemerythrin Inorganic ion transport and metabolism 153005660 Common - death-on-curing family protein Anae109_2801 50 COG3654 Doc, Prophage maintenance system killer protein General function prediction only 153005341 Common - type II secretion system protein E Anae109_2481 222 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 153004819 Nonpathogen - hypothetical protein Anae109_1957 5 None None None 153004827 Common - hypothetical protein Anae109_1965 10 None None None 153004305 Common - FAD linked oxidase domain protein Anae109_1439 198 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 153007320 Nonpathogen - phosphoesterase PA-phosphatase related Anae109_4483 3 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 153005533 Nonpathogen - hypothetical protein Anae109_2673 9 None None None 153006813 Nonpathogen - hypothetical protein Anae109_3976 1 None None None 153004398 Nonpathogen - hypothetical protein Anae109_1533 1 None None None 153006650 Common - dimethyladenosine transferase Anae109_3812 243 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 153006274 Nonpathogen - putative RecX protein Anae109_3431 1 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 153005288 Common - Hemerythrin HHE cation binding domain protein Anae109_2428 20 COG3945 COG3945, Uncharacterized conserved protein Function unknown 153003091 Nonpathogen - hypothetical protein Anae109_0214 1 None None None 153006668 Common - universal stress family protein Anae109_3830 45 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 153004059 Common - protein of unknown function DUF1028 Anae109_1192 28 COG3342 COG3342, Uncharacterized conserved protein Function unknown 153006314 Common - protein of unknown function DUF1130 Anae109_3471 47 COG5483 COG5483, Uncharacterized conserved protein Function unknown 153004077 Nonpathogen - hypothetical protein Anae109_1210 1 None None None 153004359 Nonpathogen - hypothetical protein Anae109_1493 2 None None None 153005783 Common - TRAP dicarboxylate transporter- DctP subunit Anae109_2924 93 COG4663 FcbT1, TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 153006780 Common - 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase Anae109_3943 137 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 153002999 Common - ribosomal protein S6 Anae109_0122 89 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 153005591 Common - riboflavin biosynthesis protein RibD Anae109_2731 228 COG1985 RibD, Pyrimidine reductase, riboflavin biosynthesis Coenzyme metabolism 153004826 Common - arginine decarboxylase Anae109_1964 74 COG1166 SpeA, Arginine decarboxylase (spermidine biosynthesis) Amino acid transport and metabolism 153006439 Nonpathogen - hypothetical protein Anae109_3599 1 None None None 153004215 Common - thiamine-phosphate pyrophosphorylase Anae109_1348 127 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 153004293 Common - NAD-dependent epimerase/dehydratase Anae109_1427 35 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153004925 Nonpathogen - hypothetical protein Anae109_2063 1 None None None 153005739 Nonpathogen - hypothetical protein Anae109_2880 4 None None None 153005555 Common - Peptidoglycan-binding LysM Anae109_2695 46 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 153006955 Nonpathogen - hypothetical protein Anae109_4118 1 None None None 153004728 Common - Hydroxyacylglutathione hydrolase Anae109_1866 180 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 153006864 Nonpathogen - hypothetical protein Anae109_4027 1 None None None 153003245 Common - tryptophan synthase, beta subunit Anae109_0371 224 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 153004964 Nonpathogen - hypothetical protein Anae109_2102 1 COG2268 COG2268, Uncharacterized protein conserved in bacteria Function unknown 153006585 Common - hypothetical protein Anae109_3747 6 None None None 153006172 Common - hypothetical protein Anae109_3329 19 COG5502 COG5502, Uncharacterized conserved protein Function unknown 153007327 Common - aminotransferase class V Anae109_4490 201 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 153002989 Common - hypothetical protein Anae109_0112 18 None None None 153003000 Common - Aminoacyl-tRNA hydrolase Anae109_0123 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 153004565 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Anae109_1702 6 None None None 153005808 Common - putative signal transduction protein with CBS domains Anae109_2950 102 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 153003670 Common - anti-sigma-factor antagonist Anae109_0800 30 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 153006430 Common - beta-lactamase domain protein Anae109_3590 216 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 153004098 Common - GCN5-related N-acetyltransferase Anae109_1231 10 COG0456 RimI, Acetyltransferases General function prediction only 153003998 Common - HAD-superfamily hydrolase, subfamily IIB Anae109_1131 68 COG1877 OtsB, Trehalose-6-phosphatase Carbohydrate transport and metabolism 153007124 Nonpathogen - metallophosphoesterase Anae109_4287 1 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 153005003 Common - histidine kinase Anae109_2142 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153004027 Common - molybdopterin converting factor, subunit 1 Anae109_1160 156 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 153005878 Nonpathogen - HNH endonuclease Anae109_3022 1 None None None 153004415 Nonpathogen - hypothetical protein Anae109_1551 1 None None None 153005047 Common - isocitrate dehydrogenase, NADP-dependent Anae109_2186 222 COG0538 Icd, Isocitrate dehydrogenases Energy production and conversion 153007039 Nonpathogen - hypothetical protein Anae109_4202 1 None None None 153003608 Common - acylphosphatase Anae109_0736 56 COG1254 AcyP, Acylphosphatases Energy production and conversion 153003406 Common - protein of unknown function UPF0016 Anae109_0533 74 COG2119 COG2119, Predicted membrane protein Function unknown 153005643 Common - DNA methylase N-4/N-6 domain protein Anae109_2784 131 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 153006423 Common - response regulator receiver modulated diguanylate cyclase Anae109_3583 214 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153006855 Nonpathogen - LigA Anae109_4018 1 None None None 153005392 Common - putative cold-shock DNA-binding domain protein Anae109_2532 182 COG1278 CspC, Cold shock proteins Transcription 153004261 Nonpathogen - hypothetical protein Anae109_1395 4 None None None 153006305 Common - protein of unknown function UPF0118 Anae109_3462 158 COG0628 PerM, Predicted permease General function prediction only 153003997 Common - Ferrochelatase Anae109_1130 176 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 153004403 Common - PAS/PAC sensor signal transduction histidine kinase Anae109_1538 213 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153004929 Common - TPR repeat-containing protein Anae109_2067 88 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153004688 Common - cytochrome C family protein Anae109_1826 12 None None None 153004943 Common - molybdopterin binding domain Anae109_2081 156 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 153004371 Common - 3-oxoacid CoA-transferase, A subunit Anae109_1505 99 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 153005223 Common - hypothetical protein Anae109_2362 4 None None None 153004171 Common - molybdenum cofactor synthesis domain Anae109_1304 190 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 153004538 Common - inner-membrane translocator Anae109_1675 119 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 153004878 Common - glycosyl transferase family 2 Anae109_2016 127 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 153005251 Common - Alpha,alpha-trehalose-phosphate synthase (UDP-forming) Anae109_2390 96 COG0380 OtsA, Trehalose-6-phosphate synthase Carbohydrate transport and metabolism 153006202 Common - transcriptional regulator, NifA subfamily, Fis Family Anae109_3359 185 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 153003389 Common - hydrogenase formation HypD protein Anae109_0516 109 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 153005964 Nonpathogen - hypothetical protein Anae109_3109 1 COG5569 COG5569, Uncharacterized conserved protein Function unknown 153004498 Common - major facilitator superfamily MFS_1 Anae109_1635 14 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153003943 Common - transposase mutator type Anae109_1076 84 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 153006910 Common - bacterioferritin Anae109_4073 99 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 153003651 Common - preprotein translocase, SecA subunit Anae109_0780 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 153005721 Common - cytochrome c oxidase subunit II Anae109_2862 135 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 153006145 Nonpathogen - hypothetical protein Anae109_3297 1 None None None 153006342 Common - hypothetical protein Anae109_3500 12 None None None 153003685 Common - intracellular protease, PfpI family Anae109_0815 167 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 153005857 Common - putative PAS/PAC sensor protein Anae109_3001 15 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 153004266 Common - phosphoribosylamine--glycine ligase Anae109_1400 232 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 153004510 Nonpathogen - hypothetical protein Anae109_1647 1 None None None 153006344 Nonpathogen - hypothetical protein Anae109_3502 1 None None None 153006873 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Anae109_4036 42 COG3607 COG3607, Predicted lactoylglutathione lyase General function prediction only 153004543 Common - cell wall/surface repeat protein Anae109_1680 63 None None None 153006970 Nonpathogen - hypothetical protein Anae109_4133 1 None None None 153006287 Common - hypothetical protein Anae109_3444 16 None None None 153005379 Nonpathogen - hypothetical protein Anae109_2519 1 None None None 153007140 Common - hypothetical protein Anae109_4303 10 None None None 153003422 Common - hypothetical protein Anae109_0549 10 None None None 153004876 Nonpathogen - DNA uptake protein Anae109_2014 10 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 153005767 Nonpathogen - hypothetical protein Anae109_2908 3 None None None 153004772 Common - translation elongation factor Tu Anae109_1910 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 153005875 Common - ABC transporter related Anae109_3019 249 COG3638 COG3638, ABC-type phosphate/phosphonate transport system, ATPase component Inorganic ion transport and metabolism 153007086 Nonpathogen - hypothetical protein Anae109_4249 1 None None None 153006989 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_4152 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153005709 Common - peptidase M19 renal dipeptidase Anae109_2850 100 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 153003077 Nonpathogen - hypothetical protein Anae109_0200 2 None None None 153005761 Common - hypothetical protein Anae109_2902 3 None None None 153006735 Common - metal dependent phophohydrolase Anae109_3897 31 COG2316 COG2316, Predicted hydrolase (HD superfamily) General function prediction only 153006597 Nonpathogen - Roadblock/LC7 family protein Anae109_3759 12 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 153005472 Common - cellulose biosynthesis (CelD)-like protein Anae109_2612 19 COG5653 COG5653, Protein involved in cellulose biosynthesis (CelD) Cell envelope biogenesis, outer membrane 153003449 Common - DoxX family protein Anae109_0576 30 COG2259 COG2259, Predicted membrane protein Function unknown 153005547 Common - heat shock protein HslVU, ATPase subunit HslU Anae109_2687 209 COG1220 HslU, ATP-dependent protease HslVU (ClpYQ), ATPase subunit Posttranslational modification, protein turnover, chaperones 153006499 Common - beta-lactamase domain protein Anae109_3660 16 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 153006548 Common - aspartate kinase Anae109_3710 233 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 153003172 Nonpathogen - hypothetical protein Anae109_0296 4 COG4469 CoiA, Competence protein General function prediction only 153006033 Nonpathogen - amine oxidase Anae109_3178 6 COG1231 COG1231, Monoamine oxidase Amino acid transport and metabolism 153003150 Common - putative cold-shock DNA-binding domain protein Anae109_0273 183 COG1278 CspC, Cold shock proteins Transcription 153004741 Common - ketol-acid reductoisomerase Anae109_1879 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 153006717 Common - UDP-N-acetylmuramyl-tripeptide synthetase Anae109_3879 208 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 153005883 Common - nitrogenase MoFe cofactor biosynthesis protein NifE Anae109_3027 54 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 153005310 Nonpathogen - DNA polymerase III delta Anae109_2450 11 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 153002899 Common - Stage II sporulation E family protein Anae109_0020 39 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 153004716 Common - histidine kinase Anae109_1854 223 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 153003765 Common - ABC transporter related Anae109_0897 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 153003366 Common - Smr protein/MutS2 Anae109_0493 103 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 153004198 Nonpathogen - hypothetical protein Anae109_1331 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 153005071 Common - Lytic transglycosylase catalytic Anae109_2210 135 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 153004634 Common - ABC transporter related Anae109_1772 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 153005432 Common - phage SPO1 DNA polymerase-related protein Anae109_2572 151 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 153006475 Common - ammonium transporter Anae109_3636 200 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 153004010 Common - ribosome-binding factor A Anae109_1143 183 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 153005157 Common - methyl-accepting chemotaxis sensory transducer Anae109_2296 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153003368 Common - ABC transporter related Anae109_0495 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 153003001 Common - ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5 Anae109_0124 191 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 153005258 Common - pyridoxal phosphate-dependent enzyme, D-cysteine desulfhydrase family Anae109_2397 66 COG2515 Acd, 1-aminocyclopropane-1-carboxylate deaminase Amino acid transport and metabolism 153006376 Common - methyl-accepting chemotaxis sensory transducer Anae109_3536 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153003708 Nonpathogen - hypothetical protein Anae109_0838 1 None None None 153004987 Nonpathogen - putative transmembrane anti-sigma factor Anae109_2125 1 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 153002992 Common - peptidase M14 carboxypeptidase A Anae109_0115 16 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 153004997 Common - Enoyl-CoA hydratase/isomerase Anae109_2135 190 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 153005575 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Anae109_2715 2 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 153007332 Common - ATP synthase F1, beta subunit Anae109_4495 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 153003257 Common - SirA family protein Anae109_0383 59 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 153006264 Common - ATP-dependent Clp protease, proteolytic subunit ClpP Anae109_3421 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 153005083 Common - ribosomal protein L7/L12 Anae109_2222 211 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 153003826 Nonpathogen - putative anti-sigma regulatory factor, serine/threonine protein kinase Anae109_0958 2 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 153007022 Common - 3-Oxoacyl-(acyl-carrier-protein (ACP)) synthase III domain protein Anae109_4185 118 COG3424 BcsA, Predicted naringenin-chalcone synthase Secondary metabolites biosynthesis, transport, and catabolism 153003937 Common - Domain of unknown function DUF1814 Anae109_1070 14 None None None 153004645 Nonpathogen - hypothetical protein Anae109_1783 3 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 153006466 Common - methionine-R-sulfoxide reductase Anae109_3626 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 153007076 Common - monooxygenase FAD-binding Anae109_4239 13 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 153003405 Nonpathogen - GCN5-related N-acetyltransferase Anae109_0532 3 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 153004858 Common - TatD-related deoxyribonuclease Anae109_1996 223 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 153007340 Common - GYD family protein Anae109_4503 14 COG4274 COG4274, Uncharacterized conserved protein Function unknown 153006574 Nonpathogen - hypothetical protein Anae109_3736 1 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 153004769 Common - ribosomal protein S12 Anae109_1907 240 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 153003929 Common - Domain of unknown function DUF1801 Anae109_1062 26 COG5649 COG5649, Uncharacterized conserved protein Function unknown 153004087 Nonpathogen - hypothetical protein Anae109_1220 2 None None None 153004794 Common - Adenylate kinase Anae109_1932 230 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 153005369 Nonpathogen - hypothetical protein Anae109_2509 2 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 153006614 Common - FHA domain containing protein Anae109_3776 29 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 153007194 Nonpathogen - hypothetical protein Anae109_4357 2 None None None 153006743 Nonpathogen - putative lipoprotein Anae109_3905 1 None None None 153004335 Nonpathogen - hypothetical protein Anae109_1469 1 None None None 153004482 Common - Alcohol dehydrogenase GroES domain protein Anae109_1619 209 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 153003317 Nonpathogen - hypothetical protein Anae109_0443 1 None None None 153006628 Common - phage shock protein C, PspC Anae109_3790 14 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 153006922 Common - Cystathionine beta-lyase Anae109_4085 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 153007114 Common - acyl-CoA dehydrogenase domain protein Anae109_4277 166 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 153003083 Common - Chorismate synthase Anae109_0206 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 153005752 Nonpathogen - hypothetical protein Anae109_2893 1 None None None 153006081 Nonpathogen - protein of unknown function DUF1003 Anae109_3227 11 COG4420 COG4420, Predicted membrane protein Function unknown 153003728 Common - major facilitator superfamily MFS_1 Anae109_0858 101 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 153006842 Nonpathogen - hypothetical protein Anae109_4005 1 None None None 153005690 Common - DGPFAETKE family protein Anae109_2831 46 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 153006908 Common - transcriptional regulator, MarR family Anae109_4071 41 COG1846 MarR, Transcriptional regulators Transcription 153003284 Nonpathogen - hypothetical protein Anae109_0410 1 None None None 153004806 Common - tRNA (guanine-N1)-methyltransferase Anae109_1944 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 153003714 Common - hypothetical protein Anae109_0844 30 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 153005669 Common - ribosome small subunit-dependent GTPase A Anae109_2810 163 COG1162 COG1162, Predicted GTPases General function prediction only 153004210 Common - peptidase M16 domain protein Anae109_1343 190 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 153007210 Nonpathogen - hypothetical protein Anae109_4373 2 None None None 153003207 Nonpathogen - hypothetical protein Anae109_0333 1 None None None 153005948 Common - UspA domain protein Anae109_3093 51 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 153003215 Common - protein of unknown function DUF938 Anae109_0341 49 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153006054 Common - sodium/hydrogen exchanger Anae109_3199 87 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 153007306 Nonpathogen - hypothetical protein Anae109_4469 2 None None None 153007041 Common - ubiquinone/menaquinone biosynthesis methyltransferase Anae109_4204 195 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153007313 Common - heat-inducible transcription repressor HrcA Anae109_4476 148 COG1420 HrcA, Transcriptional regulator of heat shock gene Transcription 153007169 Nonpathogen - protein of unknown function DUF1232 Anae109_4332 2 COG3339 COG3339, Uncharacterized conserved protein Function unknown 153005486 Nonpathogen - hypothetical protein Anae109_2626 1 None None None 153005754 Common - transcriptional regulator, LysR family Anae109_2895 95 COG0583 LysR, Transcriptional regulator Transcription 153005941 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_3086 175 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153006778 Nonpathogen - hypothetical protein Anae109_3941 1 None None None 153007151 Nonpathogen - OstA family protein Anae109_4314 6 COG1934 COG1934, Uncharacterized protein conserved in bacteria Function unknown 153006234 Common - protein of unknown function DUF192 Anae109_3391 88 COG1430 COG1430, Uncharacterized conserved protein Function unknown 153004302 Common - protein of unknown function DUF162 Anae109_1436 94 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 153005506 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_2646 72 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 153003691 Common - prolipoprotein diacylglyceryl transferase Anae109_0821 33 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 153005775 Common - putative GAF sensor protein Anae109_2916 16 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 153004765 Common - monofunctional biosynthetic peptidoglycan transglycosylase Anae109_1903 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 153006127 Common - short-chain dehydrogenase/reductase SDR Anae109_3278 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153006477 Common - YceI family protein Anae109_3638 120 COG2353 COG2353, Uncharacterized conserved protein Function unknown 153006659 Nonpathogen - hypothetical protein Anae109_3821 1 None None None 153004152 Common - NADH dehydrogenase (quinone) Anae109_1285 182 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 153005131 Nonpathogen - CopG-like DNA-binding protein Anae109_2270 2 None None None 153004121 Nonpathogen - hypothetical protein Anae109_1254 3 COG1633 COG1633, Uncharacterized conserved protein Function unknown 153004322 Nonpathogen - hypothetical protein Anae109_1456 6 None None None 153007160 Common - putative transcriptional regulator, GntR family Anae109_4323 213 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 153006685 Common - aminoglycoside phosphotransferase Anae109_3847 91 COG3178 COG3178, Predicted phosphotransferase related to Ser/Thr protein kinases General function prediction only 153003845 Nonpathogen - hypothetical protein Anae109_0977 2 None None None 153006446 Common - thiamineS protein Anae109_3606 36 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 153006881 Common - domain of unknown function DUF1745 Anae109_4044 41 COG4398 COG4398, Uncharacterized protein conserved in bacteria Function unknown 153004493 Common - protein of unknown function DUF309 Anae109_1630 13 COG1547 COG1547, Uncharacterized conserved protein Function unknown 153006059 Nonpathogen - hypothetical protein Anae109_3204 1 None None None 153004132 Nonpathogen - hypothetical protein Anae109_1265 4 None None None 153004735 Common - threonyl-tRNA synthetase Anae109_1873 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153005309 Common - methionyl-tRNA synthetase Anae109_2449 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153006334 Common - FAD dependent oxidoreductase Anae109_3492 82 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 153006195 Common - major facilitator superfamily MFS_1 Anae109_3352 127 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153004556 Nonpathogen - Carboxymuconolactone decarboxylase Anae109_1693 9 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 153003414 Common - Protein-glutamate O-methyltransferase Anae109_0541 148 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 153005323 Common - hypothetical protein Anae109_2463 25 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 153005518 Nonpathogen - hypothetical protein Anae109_2658 1 None None None 153007052 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase Anae109_4215 211 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 153004351 Nonpathogen - hypothetical protein Anae109_1485 1 None None None 153007049 Nonpathogen - LigA Anae109_4212 1 None None None 153003675 Common - RarD protein, DMT superfamily transporter Anae109_0805 93 COG2962 RarD, Predicted permeases General function prediction only 153003895 Common - histidine kinase Anae109_1027 217 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153005832 Common - Alcohol dehydrogenase GroES domain protein Anae109_2974 193 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 153003852 Common - protein of unknown function DUF255 Anae109_0984 106 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 153003228 Common - dihydrodipicolinate synthase Anae109_0354 230 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 153005437 Common - cytidyltransferase-related domain Anae109_2577 142 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 153004043 Common - ABC transporter related Anae109_1176 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 153006801 Common - type II secretion system protein Anae109_3964 88 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion 153006138 Common - 6-aminohexanoate-dimer hydrolase Anae109_3290 57 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 153004954 Common - transcriptional regulator, NifA subfamily, Fis Family Anae109_2092 177 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 153005202 Nonpathogen - hypothetical protein Anae109_2341 1 None None None 153004158 Common - NADH-quinone oxidoreductase, B subunit Anae109_1291 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 153003514 Common - ferredoxin Anae109_0642 114 COG0633 Fdx, Ferredoxin Energy production and conversion 153006644 Nonpathogen - metal dependent phosphohydrolase Anae109_3806 1 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 153003834 Common - multi-sensor signal transduction histidine kinase Anae109_0966 188 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 153005058 Common - GTP-binding protein LepA Anae109_2197 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 153006755 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Anae109_3917 2 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153003692 Nonpathogen - heat shock protein DnaJ-like protein Anae109_0822 2 None None None 153006114 Nonpathogen - hypothetical protein Anae109_3262 1 None None None 153004174 Common - 4-amino-4-deoxy-L-arabinose transferase Anae109_1307 30 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 153006044 Common - hypothetical protein Anae109_3189 8 None None None 153005714 Common - hypothetical protein Anae109_2855 3 COG3258 COG3258, Cytochrome c Energy production and conversion 153006530 Common - protein of unknown function DUF583 Anae109_3692 59 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 153005302 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_2442 204 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153005430 Nonpathogen - NUDIX hydrolase Anae109_2570 3 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 153005907 Common - hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit Anae109_3051 147 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 153002962 Nonpathogen - hypothetical protein Anae109_0083 1 None None None 153004933 Common - hypothetical protein Anae109_2071 11 None None None 153007171 Common - eIF-2B alpha/beta/delta-related uncharacterized protein Anae109_4334 130 COG0182 COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 153004139 Common - 2-alkenal reductase Anae109_1272 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 153005269 Common - Radical SAM domain protein Anae109_2409 202 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 153003521 Nonpathogen - GAF domain protein Anae109_0649 4 None None None 153003649 Common - peptidase M23B Anae109_0778 191 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 153007274 Nonpathogen - O-antigen polymerase Anae109_4437 1 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 153004890 Common - putative signal-transduction protein with CBS domains Anae109_2028 112 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 153004675 Common - glycosyl transferase group 1 Anae109_1813 97 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153004435 Common - molybdate ABC transporter, ATPase subunit Anae109_1572 248 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 153003116 Common - FAD dependent oxidoreductase Anae109_0239 49 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 153003239 Nonpathogen - hypothetical protein Anae109_0365 2 None None None 153004256 Common - metalloenzyme domain protein Anae109_1390 19 COG0696 GpmI, Phosphoglyceromutase Carbohydrate transport and metabolism 153005529 Nonpathogen - hypothetical protein Anae109_2669 1 None None None 153006293 Nonpathogen - hypothetical protein Anae109_3450 1 COG4982 COG4982, 3-oxoacyl- acyl-carrier protein 153004637 Common - (Isocitrate dehydrogenase (NADP(+))) kinase Anae109_1775 29 COG4579 COG4579, Isocitrate dehydrogenase kinase/phosphatase Signal transduction mechanisms 153003827 Common - Stage II sporulation E family protein Anae109_0959 105 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 153006769 Nonpathogen - hypothetical protein Anae109_3931 1 None None None 153005448 Common - Dolichyl-phosphate beta-D-mannosyltransferase Anae109_2588 185 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 153003962 Common - metallophosphoesterase Anae109_1095 81 COG1692 COG1692, Uncharacterized protein conserved in bacteria Function unknown 153003375 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), Phosphate acetyltransferase Anae109_0502 211 COG0281 SfcA, Malic enzyme Energy production and conversion 153005132 Common - hypothetical protein Anae109_2271 64 COG1606 COG1606, ATP-utilizing enzymes of the PP-loop superfamily General function prediction only 153003384 Common - Activator of Hsp90 ATPase 1 family protein Anae109_0511 49 COG3832 COG3832, Uncharacterized conserved protein Function unknown 153003567 Common - acetyl-CoA carboxylase, biotin carboxylase Anae109_0695 223 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 153003305 Common - glycosyl transferase family 2 Anae109_0431 23 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 153004005 Common - protein of unknown function DUF150 Anae109_1138 177 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 153004329 Nonpathogen - hypothetical protein Anae109_1463 2 COG0622 COG0622, Predicted phosphoesterase General function prediction only 153003031 Nonpathogen - PTS system sorbose subfamily IIB component Anae109_0154 7 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 153003103 Common - glutamate 5-kinase Anae109_0226 189 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 153005823 Nonpathogen - hypothetical protein Anae109_2965 1 None None None 153004651 Common - outer membrane efflux protein Anae109_1789 9 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 153004680 Common - glycosyl transferase family 2 Anae109_1818 210 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 153007102 Nonpathogen - hypothetical protein Anae109_4265 1 None None None 153005339 Common - GCN5-related N-acetyltransferase Anae109_2479 11 None None None 153007222 Common - beta-lactamase domain protein Anae109_4385 111 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 153004652 Common - glutaredoxin 3 Anae109_1790 132 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 153002926 Common - hypothetical protein Anae109_0047 19 None None None 153005607 Common - cytochrome c assembly protein Anae109_2747 116 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 153005851 Common - pyruvate carboxylase Anae109_2995 237 COG1038 PycA, Pyruvate carboxylase Energy production and conversion 153006568 Common - ATP/ADP translocase-like protein Anae109_3730 14 COG3202 COG3202, ATP/ADP translocase Energy production and conversion 153005637 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Anae109_2778 225 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 153006874 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_4037 151 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153006897 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_4060 96 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153004549 Common - protein of unknown function DUF542 ScdA domain protein Anae109_1686 43 COG2846 COG2846, Regulator of cell morphogenesis and NO signaling Cell division and chromosome partitioning 153007265 Common - Non-specific protein-tyrosine kinase Anae109_4428 163 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 153006326 Common - 4-hydroxyphenylpyruvate dioxygenase Anae109_3484 77 COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins Amino acid transport and metabolism / General function prediction only 153005418 Common - phosphoenolpyruvate synthase Anae109_2558 10 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 153005802 Common - diacylglycerol kinase catalytic region Anae109_2943 91 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 153006700 Common - response regulator receiver protein Anae109_3862 25 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153004456 Nonpathogen - response regulator receiver protein Anae109_1593 1 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153006018 Common - hypothetical protein Anae109_3163 8 None None None 153006061 Common - Alcohol dehydrogenase GroES domain protein Anae109_3207 150 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 153003744 Nonpathogen - hypothetical protein Anae109_0876 1 None None None 153006306 Common - peptidylprolyl isomerase FKBP-type Anae109_3463 137 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 153005322 Common - DNA repair protein RecO Anae109_2462 26 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 153006857 Nonpathogen - hypothetical protein Anae109_4020 1 None None None 153003981 Nonpathogen - hypothetical protein Anae109_1114 5 COG3330 COG3330, Uncharacterized protein conserved in bacteria Function unknown 153006754 Common - carboxyl-terminal protease Anae109_3916 181 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 153004912 Nonpathogen - hypothetical protein Anae109_2050 1 None None None 153003717 Common - SCO1/SenC family protein Anae109_0847 19 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 153005173 Common - tRNA delta(2)-isopentenylpyrophosphate transferase Anae109_2312 208 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 153003881 Common - protein of unknown function DUF541 Anae109_1013 51 COG2968 COG2968, Uncharacterized conserved protein Function unknown 153005511 Nonpathogen - hypothetical protein Anae109_2651 1 None None None 153005997 Common - putative CBS domain and cyclic nucleotide-regulated nucleotidyltransferase Anae109_3142 84 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 153005835 Common - peptidase S41 Anae109_2977 32 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 153004705 Common - hypothetical protein Anae109_1843 4 COG4485 COG4485, Predicted membrane protein Function unknown 153005889 Nonpathogen - NAD(+)--dinitrogen-reductase ADP-D-ribosyltransferase Anae109_3033 11 None None None 153005160 Common - hypothetical protein Anae109_2299 5 None None None 153005798 Common - Radical SAM domain protein Anae109_2939 57 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 153006794 Common - peptidase U62 modulator of DNA gyrase Anae109_3957 160 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 153003944 Common - hypothetical protein Anae109_1077 8 None None None 153003060 Common - Radical SAM domain protein Anae109_0183 72 COG1964 COG1964, Predicted Fe-S oxidoreductases General function prediction only 153004748 Common - integration host factor, alpha subunit Anae109_1886 211 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 153005988 Common - IMP dehydrogenase family protein Anae109_3133 237 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 153006321 Nonpathogen - hypothetical protein Anae109_3478 1 None None None 153007013 Common - proteinase inhibitor I4 serpin Anae109_4176 29 COG4826 COG4826, Serine protease inhibitor Posttranslational modification, protein turnover, chaperones 153005468 Nonpathogen - O-antigen polymerase Anae109_2608 3 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 153006047 Common - YceI family protein Anae109_3192 116 COG2353 COG2353, Uncharacterized conserved protein Function unknown 153005928 Nonpathogen - hypothetical protein Anae109_3073 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 153003536 Nonpathogen - type IV pilus assembly PilZ Anae109_0664 2 None None None 153003025 Common - metallophosphoesterase Anae109_0148 21 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 153005509 Common - phage integrase family protein Anae109_2649 137 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 153007237 Common - glutamine synthetase, type I Anae109_4400 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 153004222 Nonpathogen - ATP-dependent nuclease subunit B-like protein Anae109_1356 7 COG3857 AddB, ATP-dependent nuclease, subunit B DNA replication, recombination, and repair 153005932 Nonpathogen - hypothetical protein Anae109_3077 2 None None None 153004973 Common - N-acetylmuramoyl-L-alanine amidase Anae109_2111 178 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 153003709 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_0839 168 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153004108 Common - glycosyl transferase group 1 Anae109_1241 158 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153005356 Common - cysteinyl-tRNA synthetase Anae109_2496 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153006527 Common - orotate phosphoribosyltransferase Anae109_3689 94 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 153005332 Common - ribosomal-protein-alanine acetyltransferase Anae109_2472 203 COG0456 RimI, Acetyltransferases General function prediction only 153003250 Common - anthranilate synthase component I Anae109_0376 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 153006467 Common - peptide methionine sulfoxide reductase Anae109_3627 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 153004617 Common - peptidase M48 Ste24p Anae109_1755 129 COG4784 COG4784, Putative Zn-dependent protease General function prediction only 153004447 Common - DNA polymerase LigD polymerase domain Anae109_1584 66 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 153006726 Common - hypothetical protein Anae109_3888 2 None None None 153006221 Common - metallophosphoesterase Anae109_3378 33 None None None 153006394 Common - GCN5-related N-acetyltransferase Anae109_3554 7 None None None 153006525 Common - L-aspartate oxidase Anae109_3687 226 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 153003396 Common - nickel-dependent hydrogenase large subunit Anae109_0523 108 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 153006176 Nonpathogen - hypothetical protein Anae109_3333 1 None None None 153005652 Common - ATP-dependent protease, putative Anae109_2793 91 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 153003921 Common - hypothetical protein Anae109_1053 4 None None None 153004780 Common - ribosomal protein L16 Anae109_1918 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 153007019 Common - monooxygenase FAD-binding Anae109_4182 7 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 153006029 Common - inner-membrane translocator Anae109_3174 106 COG4603 COG4603, ABC-type uncharacterized transport system, permease component General function prediction only 153007132 Common - efflux transporter, RND family, MFP subunit Anae109_4295 88 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 153004149 Common - NADH-ubiquinone oxidoreductase chain 4L Anae109_1282 123 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 153005702 Common - protein of unknown function UPF0089 Anae109_2843 19 COG4908 COG4908, Uncharacterized protein containing a NRPS condensation (elongation) domain General function prediction only 153005428 Nonpathogen - H+transporting two-sector ATPase C subunit Anae109_2568 4 None None None 153004996 Common - 3-hydroxybutyryl-CoA dehydrogenase Anae109_2134 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 153006493 Nonpathogen - hypothetical protein Anae109_3654 1 None None None 153006105 Common - 3-demethylubiquinone-9 3-methyltransferase Anae109_3253 64 COG3865 COG3865, Uncharacterized protein conserved in bacteria Function unknown 153003928 Common - sigma54 specific transcriptional regulator, Fis family Anae109_1061 184 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 153006255 Common - Xanthine/uracil/vitamin C permease Anae109_3412 135 COG2252 COG2252, Permeases General function prediction only 153006602 Nonpathogen - hypothetical protein Anae109_3764 2 None None None 153007152 Nonpathogen - hypothetical protein Anae109_4315 3 None None None 153004467 Common - hypothetical protein Anae109_1604 35 COG3030 FxsA, Protein affecting phage T7 exclusion by the F plasmid General function prediction only 153003794 Common - protein of unknown function DUF477 Anae109_0926 41 COG3762 COG3762, Predicted membrane protein Function unknown 153004604 Nonpathogen - hypothetical protein Anae109_1742 5 None None None 153002983 Common - integral membrane sensor signal transduction histidine kinase Anae109_0106 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153006269 Common - N-acetylmuramoyl-L-alanine amidase Anae109_3426 149 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 153005004 Nonpathogen - hypothetical protein Anae109_2143 1 None None None 153005142 Common - Phosphoglycerate kinase Anae109_2281 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 153007291 Common - TolR protein Anae109_4454 6 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 153003547 Nonpathogen - hypothetical protein Anae109_0675 1 COG4967 PilV, Tfp pilus assembly protein PilV Cell motility and secretion / Intracellular trafficking and secretion 153006239 Common - Homoserine kinase Anae109_3396 65 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 153006854 Nonpathogen - LigA Anae109_4017 1 None None None 153007296 Common - hypothetical protein Anae109_4459 64 COG1691 COG1691, NCAIR mutase (PurE)-related proteins General function prediction only 153003539 Common - type IV-A pilus assembly ATPase PilB Anae109_0667 204 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 153006248 Common - penicillin-binding protein, 1A family Anae109_3405 200 COG5009 MrcA, Membrane carboxypeptidase/penicillin-binding protein Cell envelope biogenesis, outer membrane 153005149 Common - arginyl-tRNA synthetase Anae109_2288 246 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153006894 Common - Non-specific serine/threonine protein kinase Anae109_4057 130 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 153006412 Common - TonB-dependent receptor plug Anae109_3572 55 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 153003475 Common - regulatory protein ArsR Anae109_0602 48 COG0640 ArsR, Predicted transcriptional regulators Transcription 153003061 Nonpathogen - outer membrane lipoprotein carrier protein LolA Anae109_0184 8 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 153003811 Nonpathogen - hypothetical protein Anae109_0943 1 None None None 153003244 Common - tryptophan synthase, alpha subunit Anae109_0370 216 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 153002935 Common - uracil-xanthine permease Anae109_0056 123 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 153006135 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Anae109_3287 6 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 153005316 Common - FHA domain containing protein Anae109_2456 45 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 153005695 Nonpathogen - Vitamin K epoxide reductase Anae109_2836 2 COG4243 COG4243, Predicted membrane protein Function unknown 153006367 Common - OmpA/MotB domain protein Anae109_3527 140 COG1360 MotB, Flagellar motor protein Cell motility and secretion 153006941 Common - FeoA family protein Anae109_4104 67 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 153005921 Common - transcriptional regulator, TraR/DksA family Anae109_3066 16 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 153006607 Common - tRNA pseudouridine synthase D TruD Anae109_3769 77 COG0585 COG0585, Uncharacterized conserved protein Function unknown 153005440 Common - tetraacyldisaccharide 4'-kinase Anae109_2580 125 COG1663 LpxK, Tetraacyldisaccharide-1-P 4'-kinase Cell envelope biogenesis, outer membrane 153002890 Nonpathogen - DSBA oxidoreductase Anae109_0011 2 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 153003621 Nonpathogen - hypothetical protein Anae109_0749 2 None None None 153004542 Common - ABC transporter related Anae109_1679 248 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 153004365 Nonpathogen - hypothetical protein Anae109_1499 5 None None None 153005165 Nonpathogen - hypothetical protein Anae109_2304 1 None None None 153004949 Common - phospholipid/glycerol acyltransferase Anae109_2087 63 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 153003557 Nonpathogen - putative transcriptional regulator, XRE family Anae109_0685 4 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 153004361 Common - phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase Anae109_1495 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 153006096 Common - GreA/GreB family elongation factor Anae109_3244 66 COG0782 GreA, Transcription elongation factor Transcription 153005711 Nonpathogen - hypothetical protein Anae109_2852 3 None None None 153003667 Nonpathogen - Radical SAM domain protein Anae109_0797 4 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 153005498 Nonpathogen - PBS lyase HEAT domain protein repeat-containing protein Anae109_2638 1 None None None 153004615 Common - 2-isopropylmalate synthase/homocitrate synthase family protein Anae109_1753 200 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 153004755 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_1893 43 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 153005355 Nonpathogen - hypothetical protein Anae109_2495 1 None None None 153003991 Common - acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase Anae109_1124 152 COG1043 LpxA, Acyl- acyl carrier protein 153005013 Common - NUDIX hydrolase Anae109_2152 18 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 153006282 Nonpathogen - hypothetical protein Anae109_3439 1 None None None 153004273 Common - Methyltransferase type 11 Anae109_1407 3 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 153006915 Nonpathogen - membrane protein-like protein Anae109_4078 4 COG2324 COG2324, Predicted membrane protein Function unknown 153005363 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Anae109_2503 2 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 153003357 Common - Activator of Hsp90 ATPase 1 family protein Anae109_0483 22 COG3832 COG3832, Uncharacterized conserved protein Function unknown 153006786 Nonpathogen - HEAT domain containing protein Anae109_3949 2 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 153006983 Common - NAD-dependent epimerase/dehydratase Anae109_4146 111 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153006020 Common - Electron transfer flavoprotein alpha subunit Anae109_3165 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 153004145 Common - PHP domain protein Anae109_1278 118 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 153005917 Common - channel protein, hemolysin III family Anae109_3062 62 COG1272 COG1272, Predicted membrane protein, hemolysin III homolog General function prediction only 153005807 Common - tRNA/rRNA methyltransferase (SpoU) Anae109_2949 153 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 153004757 Common - thiamine pyrophosphate protein domain protein TPP-binding Anae109_1895 111 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 153007147 Common - putative PTS IIA-like nitrogen-regulatory protein PtsN Anae109_4310 133 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 153006976 Common - exodeoxyribonuclease III Xth Anae109_4139 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 153004897 Common - rhodanese domain protein Anae109_2035 2 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 153005950 Common - tRNA synthetase class I (M) Anae109_3095 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153005273 Common - Chloride channel core Anae109_2413 146 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 153006762 Common - ferric uptake regulator, Fur family Anae109_3924 190 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 153003166 Common - MotA/TolQ/ExbB proton channel Anae109_0290 150 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 153003163 Common - pseudouridine synthase, RluA family Anae109_0287 214 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 153003344 Common - response regulator receiver modulated CheB methylesterase Anae109_0470 151 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 153004166 Common - major facilitator superfamily MFS_1 Anae109_1299 109 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153006454 Common - hypothetical protein Anae109_3614 41 COG1741 COG1741, Pirin-related protein General function prediction only 153003550 Common - hypothetical protein Anae109_0678 13 None None None 153007281 Common - glycosyl transferase family 2 Anae109_4444 147 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 153004690 Common - hypothetical protein Anae109_1828 6 COG4485 COG4485, Predicted membrane protein Function unknown 153003487 Common - response regulator receiver protein Anae109_0615 184 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153006185 Nonpathogen - hypothetical protein Anae109_3342 1 None None None 153007248 Nonpathogen - phosphate-selective porin O and P Anae109_4411 1 COG3746 OprP, Phosphate-selective porin Inorganic ion transport and metabolism 153005215 Nonpathogen - hypothetical protein Anae109_2354 1 None None None 153005246 Nonpathogen - hypothetical protein Anae109_2385 1 None None None 153006649 Nonpathogen - hypothetical protein Anae109_3811 1 None None None 153004789 Common - ribosomal protein L18 Anae109_1927 211 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 153005247 Nonpathogen - hypothetical protein Anae109_2386 2 None None None 153003048 Common - protein of unknown function DUF814 Anae109_0171 66 COG1293 COG1293, Predicted RNA-binding protein homologous to eukaryotic snRNP Transcription 153003662 Nonpathogen - transcriptional regulator, MarR family Anae109_0791 5 COG1846 MarR, Transcriptional regulators Transcription 153004197 Common - GCN5-related N-acetyltransferase Anae109_1330 90 COG2153 ElaA, Predicted acyltransferase General function prediction only 153005066 Common - two component transcriptional regulator, Fis family Anae109_2205 225 COG4567 COG4567, Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain Signal transduction mechanisms / Transcription 153004628 Common - glycoside hydrolase family 57 Anae109_1766 24 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 153005441 Common - lipopolysaccharide heptosyltransferase II Anae109_2581 70 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 153006537 Common - aspartate-semialdehyde dehydrogenase Anae109_3699 169 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 153002917 Nonpathogen - hypothetical protein Anae109_0038 1 None None None 153004068 Common - GTPase-like protein Anae109_1201 18 COG2229 COG2229, Predicted GTPase General function prediction only 153004574 Nonpathogen - hypothetical protein Anae109_1711 1 None None None 153004285 Common - peptidase S58 DmpA Anae109_1419 44 COG3191 DmpA, L-aminopeptidase/D-esterase Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153003425 Common - Uncharacterized protein UPF0065 Anae109_0552 67 COG3181 COG3181, Uncharacterized protein conserved in bacteria Function unknown 153004032 Nonpathogen - hypothetical protein Anae109_1165 1 None None None 153005538 Common - hypothetical protein Anae109_2678 28 COG2030 MaoC, Acyl dehydratase Lipid metabolism 153003232 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Anae109_0358 2 None None None 153006280 Common - ribosomal protein L13 Anae109_3437 219 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 153005617 Common - Nitric-oxide reductase Anae109_2758 100 COG3256 NorB, Nitric oxide reductase large subunit Inorganic ion transport and metabolism 153006962 Common - cytochrome c biogenesis protein transmembrane region Anae109_4125 74 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 153003642 Nonpathogen - hypothetical protein Anae109_0771 2 COG5373 COG5373, Predicted membrane protein Function unknown 153006969 Common - hypothetical protein Anae109_4132 23 None None None 153007217 Common - DNA-3-methyladenine glycosylase Anae109_4380 84 COG2094 Mpg, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 153004523 Common - protein of unknown function DUF355 Anae109_1660 33 COG1839 COG1839, Uncharacterized conserved protein Function unknown 153005976 Common - secretion protein HlyD family protein Anae109_3121 98 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 153007229 Nonpathogen - Tetratricopeptide TPR_4 Anae109_4392 2 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 153006514 Nonpathogen - hypothetical protein Anae109_3675 1 None None None 153003977 Common - integral membrane sensor signal transduction histidine kinase Anae109_1110 196 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 153004397 Common - L-carnitine dehydratase/bile acid-inducible protein F Anae109_1532 115 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 153004078 Common - NAD-dependent epimerase/dehydratase Anae109_1211 180 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153004471 Nonpathogen - hypothetical protein Anae109_1608 2 None None None 153005559 Common - response regulator receiver Anae109_2699 33 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 153005477 Nonpathogen - hypothetical protein Anae109_2617 2 None None None 153003507 Nonpathogen - hypothetical protein Anae109_0635 3 None None None 153004304 Common - L-lactate transport Anae109_1438 102 COG1620 LldP, L-lactate permease Energy production and conversion 153003477 Common - Activator of Hsp90 ATPase 1 family protein Anae109_0604 53 COG3832 COG3832, Uncharacterized conserved protein Function unknown 153006824 Common - protein of unknown function DUF1156 Anae109_3987 46 COG1743 COG1743, Adenine-specific DNA methylase containing a Zn-ribbon DNA replication, recombination, and repair 153003786 Common - TfuA domain protein core Anae109_0918 25 COG3482 COG3482, Uncharacterized conserved protein Function unknown 153006592 Common - NmrA family protein Anae109_3754 35 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153005042 Common - protein of unknown function DUF21 Anae109_2181 219 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 153004234 Common - rod shape-determining protein MreC Anae109_1368 132 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 153004842 Common - TonB family protein Anae109_1980 32 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 153005371 Common - acetyl-CoA carboxylase, carboxyl transferase, beta subunit Anae109_2511 218 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 153005816 Nonpathogen - hypothetical protein Anae109_2958 1 None None None 153006213 Common - hypothetical protein Anae109_3370 4 None None None 153003177 Common - Ribonuclease H Anae109_0302 208 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 153005674 Common - MOSC domain containing protein Anae109_2815 126 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 153006356 Nonpathogen - hypothetical protein Anae109_3514 1 None None None 153006507 Common - response regulator receiver protein Anae109_3668 142 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 153005095 Nonpathogen - diacylglycerol kinase catalytic region Anae109_2234 3 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 153004122 Nonpathogen - NUDIX hydrolase Anae109_1255 2 None None None 153005346 Common - Serine O-acetyltransferase Anae109_2486 190 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 153007125 Common - phospholipid/glycerol acyltransferase Anae109_4288 23 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 153003912 Common - protein of unknown function DUF214 Anae109_1044 29 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 153007080 Nonpathogen - hypothetical protein Anae109_4243 9 None None None 153003659 Common - adenine phosphoribosyltransferase Anae109_0788 170 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 153004165 Nonpathogen - hypothetical protein Anae109_1298 1 None None None 153006357 Nonpathogen - hypothetical protein Anae109_3517 2 None None None 153004955 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Anae109_2093 2 None None None 153005404 Common - DEAD/DEAH box helicase domain protein Anae109_2544 241 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 153004528 Common - methylmalonate-semialdehyde dehydrogenase Anae109_1665 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 153005374 Nonpathogen - phytoene dehydrogenase Anae109_2514 3 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 153006580 Nonpathogen - hypothetical protein Anae109_3742 1 None None None 153003607 Common - DNA ligase, NAD-dependent Anae109_0735 220 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 153004544 Common - aldo/keto reductase Anae109_1681 202 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 153003034 Common - Phosphotransferase system, phosphocarrier protein HPr Anae109_0157 156 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 153004928 Common - aminotransferase class I and II Anae109_2066 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 153003915 Common - hypothetical protein Anae109_1047 18 COG4087 COG4087, Soluble P-type ATPase General function prediction only 153006171 Common - transport-associated Anae109_3328 44 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 153007326 Nonpathogen - hypothetical protein Anae109_4489 2 COG5336 COG5336, Uncharacterized protein conserved in bacteria Function unknown 153004328 Common - uncharacterised conserved protein UCP016719 Anae109_1462 51 COG3876 COG3876, Uncharacterized protein conserved in bacteria Function unknown 153003258 Common - thiamine biosynthesis protein Anae109_0384 29 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 153006005 Nonpathogen - hypothetical protein Anae109_3150 1 None None None 153004877 Nonpathogen - MJ0042 family finger-like protein Anae109_2015 4 None None None 153004138 Common - glutamine amidotransferase, class-II Anae109_1271 21 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 153004414 Common - glutathione-dependent formaldehyde-activating GFA Anae109_1550 51 COG3791 COG3791, Uncharacterized conserved protein Function unknown 153003440 Common - RND efflux system, outer membrane lipoprotein, NodT family Anae109_0567 107 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 153005519 Nonpathogen - hypothetical protein Anae109_2659 1 None None None 153006476 Common - glycosyl transferase group 1 Anae109_3637 93 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153005415 Common - Alcohol dehydrogenase GroES domain protein Anae109_2555 200 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 153003982 Common - Domain of unknown function DUF1957 Anae109_1115 35 COG1543 COG1543, Uncharacterized conserved protein Function unknown 153005563 Common - Amylo-alpha-16-glucosidase Anae109_2703 53 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 153006169 Common - glucose-6-phosphate 1-dehydrogenase Anae109_3326 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 153003990 Common - beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ Anae109_1123 185 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 153006313 Common - hypothetical protein Anae109_3470 4 COG4095 COG4095, Uncharacterized conserved protein Function unknown 153007305 Common - helicase c2 Anae109_4468 130 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 153006311 Common - DEAD/DEAH box helicase domain protein Anae109_3468 125 COG4581 COG4581, Superfamily II RNA helicase DNA replication, recombination, and repair 153004271 Common - ABC-2 type transporter Anae109_1405 115 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 153005170 Common - cytidylate kinase Anae109_2309 204 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 153003758 Common - integral membrane sensor signal transduction histidine kinase Anae109_0890 204 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153004250 Common - ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent Anae109_1384 224 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 153004352 Nonpathogen - hypothetical protein Anae109_1486 2 None None None 153003996 Common - oxygen-independent coproporphyrinogen III oxidase Anae109_1129 202 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 153004821 Nonpathogen - hypothetical protein Anae109_1959 2 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 153005644 Common - CDP-alcohol phosphatidyltransferase Anae109_2785 43 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 153006203 Common - cyclic nucleotide-regulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase Anae109_3360 245 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 153005460 Nonpathogen - hypothetical protein Anae109_2600 2 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 153004903 Common - beta-lactamase domain protein Anae109_2041 123 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 153003291 Common - phosphate-selective porin O and P Anae109_0417 3 None None None 153004372 Common - 3-oxoacid CoA-transferase, B subunit Anae109_1506 91 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 153005384 Common - Glycine dehydrogenase (decarboxylating) Anae109_2524 172 COG0403 GcvP, Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain Amino acid transport and metabolism 153005611 Common - hemerythrin-like metal-binding protein Anae109_2752 12 COG2703 COG2703, Hemerythrin Inorganic ion transport and metabolism 153005252 Nonpathogen - response regulator receiver protein Anae109_2391 1 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153004875 Common - histidine ammonia-lyase Anae109_2013 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 153005685 Nonpathogen - hypothetical protein Anae109_2826 1 None None None 153006486 Common - permease Anae109_3647 88 COG0701 COG0701, Predicted permeases General function prediction only 153005546 Common - acetylornithine and succinylornithine aminotransferase Anae109_2686 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 153004942 Common - dTMP kinase Anae109_2080 166 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 153004970 Nonpathogen - cytochrome c class III Anae109_2108 4 None None None 153003109 Nonpathogen - hypothetical protein Anae109_0232 1 None None None 153007067 Common - hypothetical protein Anae109_4230 32 COG1982 LdcC, Arginine/lysine/ornithine decarboxylases Amino acid transport and metabolism 153006464 Nonpathogen - hypothetical protein Anae109_3624 1 None None None 153003699 Common - 2-oxoglutarate dehydrogenase, E1 subunit Anae109_0829 150 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 153004492 Common - para-aminobenzoate synthase, subunit I Anae109_1629 221 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 153005490 Common - glycosyl transferase group 1 Anae109_2630 216 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153005290 Common - homoserine O-acetyltransferase Anae109_2430 210 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 153006345 Common - hypothetical protein Anae109_3503 8 None None None 153003560 Common - type IV pilus biogenesis protein PilO Anae109_0688 27 COG3167 PilO, Tfp pilus assembly protein PilO Cell motility and secretion / Intracellular trafficking and secretion 153004967 Nonpathogen - hypothetical protein Anae109_2105 1 None None None 153004163 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_1296 176 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 153006447 Common - UBA/THIF-type NAD/FAD binding protein Anae109_3607 232 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 153006113 Common - DsrE family protein Anae109_3261 24 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 153003942 Common - hypothetical protein Anae109_1075 8 None None None 153006343 Common - Endonuclease/exonuclease/phosphatase Anae109_3501 5 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 153006865 Nonpathogen - hypothetical protein Anae109_4028 5 None None None 153003370 Common - protein of unknown function DUF214 Anae109_0497 14 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 153004749 Common - 6-pyruvoyl tetrahydropterin synthase and hypothetical protein Anae109_1887 143 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 153006608 Common - OmpA/MotB domain protein Anae109_3770 174 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 153005122 Common - CMP/dCMP deaminase zinc-binding Anae109_2261 89 COG2131 ComEB, Deoxycytidylate deaminase Nucleotide transport and metabolism 153005899 Common - Formate dehydrogenase Anae109_3043 181 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 153004537 Common - 3-hydroxybutyrate dehydrogenase Anae109_1674 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153006365 Common - glycosyl hydrolase, BNR repeat Anae109_3525 31 None None None 153003654 Nonpathogen - HhH-GPD family protein Anae109_0783 2 COG0122 AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 153006110 Common - Rhodanese domain protein Anae109_3258 131 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 153006167 Nonpathogen - hypothetical protein Anae109_3324 1 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 153003271 Common - Silent information regulator protein Sir2 Anae109_0397 151 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 153006954 Common - putative cold-shock DNA-binding domain protein Anae109_4117 182 COG1278 CspC, Cold shock proteins Transcription 153004727 Nonpathogen - Glyoxalase/bleomycin resistance protein/dioxygenase Anae109_1865 4 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 153006880 Nonpathogen - hypothetical protein Anae109_4043 3 None None None 153006961 Common - hypothetical protein Anae109_4124 11 None None None 153004097 Common - glycosyl transferase group 1 Anae109_1230 93 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153003175 Nonpathogen - hypothetical protein Anae109_0300 1 None None None 153005901 Common - GAF modulated sigma54 specific transcriptional regulator, Fis family Anae109_3045 178 COG3284 AcoR, Transcriptional activator of acetoin/glycerol metabolism Secondary metabolites biosynthesis, transport, and catabolism / Transcription 153007253 Common - Extracellular ligand-binding receptor Anae109_4416 153 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 153004020 Nonpathogen - hypothetical protein Anae109_1153 3 None None None 153006452 Common - hypothetical protein Anae109_3612 8 None None None 153004184 Common - SNARE associated Golgi protein Anae109_1317 167 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 153005680 Common - glutathione-dependent formaldehyde-activating GFA Anae109_2821 47 COG3791 COG3791, Uncharacterized conserved protein Function unknown 153003643 Common - hypothetical protein Anae109_0772 21 None None None 153005599 Common - 3-oxoacyl-(acyl-carrier-protein) synthase III Anae109_2739 221 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 153006927 Nonpathogen - hypothetical protein Anae109_4090 1 None None None 153005732 Common - Saccharopine dehydrogenase Anae109_2873 48 COG3268 COG3268, Uncharacterized conserved protein Function unknown 153006928 Nonpathogen - hypothetical protein Anae109_4091 1 None None None 153003432 Common - DoxX family protein Anae109_0559 49 COG2259 COG2259, Predicted membrane protein Function unknown 153003952 Common - hypothetical protein Anae109_1085 6 None None None 153003976 Common - short-chain dehydrogenase/reductase SDR Anae109_1109 233 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 153004235 Nonpathogen - hypothetical protein Anae109_1369 1 None None None 153004377 Common - Ste24 endopeptidase Anae109_1511 62 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 153004469 Common - FAD linked oxidase domain protein Anae109_1606 85 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 153006931 Common - heavy metal efflux pump, CzcA family Anae109_4094 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 153006153 Common - hypothetical protein Anae109_3309 31 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 153005536 Common - Male sterility domain Anae109_2676 55 COG3320 COG3320, Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 153004421 Common - protein of unknown function DUF692 Anae109_1558 62 COG3220 COG3220, Uncharacterized protein conserved in bacteria Function unknown 153003574 Common - Ppx/GppA phosphatase Anae109_0702 175 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 153003734 Common - superfamily I DNA and RNA helicase-like protein Anae109_0864 32 COG3973 COG3973, Superfamily I DNA and RNA helicases General function prediction only 153005431 Common - protein of unknown function DUF763 Anae109_2571 32 COG1415 COG1415, Uncharacterized conserved protein Function unknown 153005863 Common - DNA photolyase FAD-binding Anae109_3007 28 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 153003321 Common - Ribulose-phosphate 3-epimerase Anae109_0447 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 153004260 Nonpathogen - hypothetical protein Anae109_1394 1 None None None 153002916 Nonpathogen - hypothetical protein Anae109_0037 5 None None None 153003496 Common - transcriptional regulator-like protein Anae109_0624 51 COG2378 COG2378, Predicted transcriptional regulator Transcription 153004550 Common - sigma54 specific transcriptional regulator, Fis family Anae109_1687 166 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 153005040 Common - PfkB domain protein Anae109_2179 101 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 153004979 Common - tyrosine recombinase XerD Anae109_2117 225 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 153004380 Nonpathogen - hypothetical protein Anae109_1515 1 None None None 153005393 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Anae109_2533 2 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153005342 Nonpathogen - putative regulatory protein, FmdB family Anae109_2482 5 COG2331 COG2331, Uncharacterized protein conserved in bacteria Function unknown 153006620 Common - respiratory-chain NADH dehydrogenase, subunit 1 Anae109_3782 57 COG0650 HyfC, Formate hydrogenlyase subunit 4 Energy production and conversion 153004924 Common - cation diffusion facilitator family transporter Anae109_2062 166 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 153003515 Common - protein of unknown function DUF528 Anae109_0643 43 COG2975 COG2975, Uncharacterized protein conserved in bacteria Function unknown 153005768 Common - amino acid permease-associated region Anae109_2909 24 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 153003137 Nonpathogen - hypothetical protein Anae109_0260 4 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 153005532 Common - GTP-binding protein HSR1-related Anae109_2672 208 COG0218 COG0218, Predicted GTPase General function prediction only 153003889 Nonpathogen - hypothetical protein Anae109_1021 3 None None None 153004117 Common - polysaccharide biosynthesis protein CapD Anae109_1250 159 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153005587 Common - NusB antitermination factor Anae109_2727 202 COG0781 NusB, Transcription termination factor Transcription 153004629 Common - AMP-dependent synthetase and ligase Anae109_1767 213 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 153004446 Common - short-chain dehydrogenase/reductase SDR Anae109_1583 231 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153003575 Common - TolB domain protein Anae109_0703 163 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 153003115 Common - acriflavin resistance protein Anae109_0238 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 153004825 Common - ABC transporter related Anae109_1963 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 153005854 Common - hemerythrin-like metal-binding protein Anae109_2998 45 COG2703 COG2703, Hemerythrin Inorganic ion transport and metabolism 153007042 Common - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Anae109_4205 152 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 153004988 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Anae109_2126 152 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153005965 Common - hypothetical protein Anae109_3110 5 None None None 153005352 Common - two component, sigma54 specific, transcriptional regulator, Fis family Anae109_2492 222 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153004870 Common - formate dehydrogenase, alpha subunit Anae109_2008 173 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 153005776 Common - hypothetical protein Anae109_2917 5 None None None 153003890 Nonpathogen - outer membrane efflux protein Anae109_1022 1 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 153004627 Common - phosphomethylpyrimidine kinase Anae109_1765 210 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 153006986 Nonpathogen - phosphoribosyltransferase Anae109_4149 2 COG2236 COG2236, Predicted phosphoribosyltransferases General function prediction only 153007096 Common - TonB family protein Anae109_4259 14 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 153003039 Nonpathogen - hypothetical protein Anae109_0162 3 None None None 153005724 Common - electron transport protein SCO1/SenC Anae109_2865 83 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 153007058 Nonpathogen - hypothetical protein Anae109_4221 1 None None None 153004306 Common - two component transcriptional regulator, LytTR family Anae109_1440 210 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 153004938 Nonpathogen - hypothetical protein Anae109_2076 2 None None None 153004911 Common - ABC transporter related Anae109_2049 248 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 153005782 Common - Tripartite ATP-independent periplasmic transporter DctQ component Anae109_2923 73 COG4665 FcbT2, TRAP-type mannitol/chloroaromatic compound transport system, small permease component Secondary metabolites biosynthesis, transport, and catabolism 153004391 Nonpathogen - hypothetical protein Anae109_1526 1 None None None 153007173 Common - glutamyl-tRNA(Gln) amidotransferase, B subunit Anae109_4336 211 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 153006273 Common - Tetratricopeptide domain protein Anae109_3430 126 COG4105 ComL, DNA uptake lipoprotein General function prediction only 153006812 Nonpathogen - hypothetical protein Anae109_3975 2 None None None 153004666 Common - glycine cleavage H-protein Anae109_1804 145 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 153004907 Common - GrpE protein Anae109_2045 53 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 153002956 Common - Phosphomethylpyrimidine kinase Anae109_0077 141 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 153005668 Common - translation initiation factor IF-1 Anae109_2809 212 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 153007271 Common - glycosyl transferase group 1 Anae109_4434 77 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153003729 Common - molybdenum cofactor biosynthesis protein A Anae109_0859 196 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 153006540 Common - peptidase M22 glycoprotease Anae109_3702 93 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 153004292 Common - glycosyl transferase group 1 Anae109_1426 208 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153006210 Nonpathogen - hypothetical protein Anae109_3367 10 COG4911 COG4911, Uncharacterized conserved protein Function unknown 153005501 Nonpathogen - hypothetical protein Anae109_2641 1 None None None 153006551 Common - hypothetical protein Anae109_3713 6 None None None 153006946 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_4109 159 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153005926 Common - alpha amylase catalytic region Anae109_3071 108 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 153003283 Nonpathogen - Tetratricopeptide TPR_4 Anae109_0409 3 None None None 153005447 Common - multiple antibiotic resistance (MarC)-related protein Anae109_2587 143 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 153005465 Nonpathogen - hypothetical protein Anae109_2605 10 None None None 153005753 Nonpathogen - hypothetical protein Anae109_2894 1 None None None 153003342 Nonpathogen - putative CheW protein Anae109_0468 16 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153003620 Common - secretory protein YscJ/FliF family protein Anae109_0748 74 COG4669 EscJ, Type III secretory pathway, lipoprotein EscJ Intracellular trafficking and secretion 153003720 Common - cytochrome c oxidase subunit III Anae109_0850 158 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 153003802 Nonpathogen - protein of unknown function DUF107 Anae109_0934 1 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 153007011 Common - serine/threonine protein kinase Anae109_4174 151 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153004028 Common - putative membrane-associated zinc metalloprotease Anae109_1161 209 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 153003835 Common - O-acetylhomoserine/O-acetylserine sulfhydrylase Anae109_0967 206 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 153005029 Common - Phosphopyruvate hydratase Anae109_2168 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 153004211 Common - hypothetical protein Anae109_1344 21 None None None 153006627 Common - Methyltransferase type 12 Anae109_3789 3 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153005638 Nonpathogen - hypothetical protein Anae109_2779 1 None None None 153006023 Common - acyl-CoA dehydrogenase domain protein Anae109_3168 146 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 153005110 Nonpathogen - hypothetical protein Anae109_2249 1 None None None 153006130 Common - transposase, IS630 family Anae109_3282 9 None None None 153003214 Nonpathogen - heat shock protein DnaJ-like protein Anae109_0340 4 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 153005189 Nonpathogen - PpiC-type peptidyl-prolyl cis-trans isomerase Anae109_2328 3 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 153005981 Common - Vitamin K epoxide reductase Anae109_3126 62 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 153007134 Common - protein of unknown function DUF214 Anae109_4297 176 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 153005174 Common - histidyl-tRNA synthetase Anae109_2313 248 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153006071 Common - NAD-dependent epimerase/dehydratase Anae109_3217 232 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 153002968 Nonpathogen - hypothetical protein Anae109_0089 1 None None None 153006062 Common - Alcohol dehydrogenase zinc-binding domain protein Anae109_3208 173 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 153003092 Nonpathogen - hypothetical protein Anae109_0215 1 None None None 153003896 Common - sulfatase Anae109_1028 72 COG1368 MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily Cell envelope biogenesis, outer membrane 153006335 Nonpathogen - hypothetical protein Anae109_3493 1 None None None 153003102 Common - hypothetical protein Anae109_0225 4 None None None 153003185 Nonpathogen - hypothetical protein Anae109_0310 3 None None None 153005831 Common - NAD(P)(+) transhydrogenase (AB-specific) Anae109_2973 123 COG1282 PntB, NAD/NADP transhydrogenase beta subunit Energy production and conversion 153007146 Nonpathogen - hypothetical protein Anae109_4309 1 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 153003381 Common - 1-acyl-sn-glycerol-3-phosphate acyltransferase Anae109_0508 204 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 153005616 Nonpathogen - hypothetical protein Anae109_2757 1 None None None 153004131 Common - glutamyl-tRNA synthetase Anae109_1264 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 153005894 Common - amino acid carrier protein Anae109_3038 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 153005224 Common - metallophosphoesterase Anae109_2363 20 COG1409 Icc, Predicted phosphohydrolases General function prediction only 153007161 Common - phospholipid/glycerol acyltransferase Anae109_4324 39 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 153007223 Nonpathogen - hypothetical protein Anae109_4386 1 None None None 153003415 Nonpathogen - hypothetical protein Anae109_0542 1 None None None 153002904 Nonpathogen - response regulator receiver protein Anae109_0025 1 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 153005485 Common - hypothetical protein Anae109_2625 5 COG5434 PGU1, Endopygalactorunase Cell envelope biogenesis, outer membrane 153004129 Common - intracellular protease, PfpI family Anae109_1262 140 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 153004734 Nonpathogen - hypothetical protein Anae109_1872 3 None None None 153004880 Nonpathogen - hypothetical protein Anae109_2018 2 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 153006566 Nonpathogen - cyclic nucleotide-binding protein Anae109_3728 2 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 153006609 Nonpathogen - putative treponemal membrane protein B precursor-like protein Anae109_3771 1 None None None 153005940 Common - Polysulphide reductase NrfD Anae109_3085 49 COG5557 COG5557, Polysulphide reductase Energy production and conversion 153005626 Nonpathogen - hypothetical protein Anae109_2767 5 None None None 153005072 Common - 3'-5' exonuclease Anae109_2211 125 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 153002886 Nonpathogen - hypothetical protein Anae109_0007 4 None None None 153005623 Common - short-chain dehydrogenase/reductase SDR Anae109_2764 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153004321 Common - Extracellular ligand-binding receptor Anae109_1455 144 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 153007048 Common - PAS/PAC sensor signal transduction histidine kinase Anae109_4211 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153003592 Nonpathogen - hypothetical protein Anae109_0720 4 None None None 153004764 Nonpathogen - hypothetical protein Anae109_1902 1 None None None 153003078 Common - chorismate mutase Anae109_0201 39 COG4401 AroH, Chorismate mutase Amino acid transport and metabolism 153005762 Common - pyruvate phosphate dikinase PEP/pyruvate-binding Anae109_2903 16 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 153007051 Common - modification methylase, HemK family Anae109_4214 230 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 153005203 Common - ammonium transporter Anae109_2342 201 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 153004555 Common - acriflavin resistance protein Anae109_1692 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 153003068 Common - TGS domain protein Anae109_0191 115 COG1163 DRG, Predicted GTPase General function prediction only 153006404 Common - hypothetical protein Anae109_3564 41 None None None 153004768 Common - A/G-specific adenine glycosylase Anae109_1906 210 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 153005466 Nonpathogen - hypothetical protein Anae109_2606 4 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 153003876 Common - Ku family containing protein Anae109_1008 63 COG1273 COG1273, Uncharacterized conserved protein Function unknown 153003367 Common - hypothetical protein Anae109_0494 15 None None None 153003847 Nonpathogen - hypothetical protein Anae109_0979 4 None None None 153006980 Common - transcriptional regulator, MarR family Anae109_4143 92 COG1846 MarR, Transcriptional regulators Transcription 153005147 Common - Cupin 2 conserved barrel domain protein Anae109_2286 49 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 153007085 Common - hypothetical protein Anae109_4248 7 None None None 153005884 Common - nitrogenase molybdenum-iron protein beta chain Anae109_3028 50 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 153006758 Nonpathogen - hypothetical protein Anae109_3920 1 None None None 153006734 Nonpathogen - hypothetical protein Anae109_3896 1 None None None 153003715 Common - hypothetical protein Anae109_0845 23 None None None 153003318 Common - Uracil-DNA glycosylase superfamily Anae109_0444 106 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 153004715 Common - GTP-binding protein TypA Anae109_1853 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 153007312 Common - GrpE protein Anae109_4475 125 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 153002903 Common - helix-turn-helix domain protein Anae109_0024 14 COG1813 COG1813, Predicted transcription factor, homolog of eukaryotic MBF1 Transcription 153004088 Nonpathogen - hypothetical protein Anae109_1221 1 None None None 153005698 Common - Appr-1-p processing domain protein Anae109_2839 116 COG2110 COG2110, Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 General function prediction only 153006635 Nonpathogen - hypothetical protein Anae109_3797 2 None None None 153007060 Common - DNA methylase N-4/N-6 domain protein Anae109_4223 45 COG1041 COG1041, Predicted DNA modification methylase DNA replication, recombination, and repair 153005813 Nonpathogen - hypothetical protein Anae109_2955 2 None None None 153003265 Common - MaoC domain protein dehydratase Anae109_0391 35 COG2030 MaoC, Acyl dehydratase Lipid metabolism 153003345 Nonpathogen - TatD-related deoxyribonuclease Anae109_0471 2 COG1099 COG1099, Predicted metal-dependent hydrolases with the TIM-barrel fold General function prediction only 153004199 Nonpathogen - HNH endonuclease Anae109_1332 3 COG1403 McrA, Restriction endonuclease Defense mechanisms 153003777 Common - FHA domain containing protein Anae109_0909 49 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 153004096 Common - UDP-glucose/GDP-mannose dehydrogenase Anae109_1229 207 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 153006559 Common - phospholipase D/Transphosphatidylase Anae109_3721 157 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 153004106 Common - glycosyl transferase family 2 Anae109_1239 31 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 153005452 Common - regulatory protein ArsR Anae109_2592 110 COG0640 ArsR, Predicted transcriptional regulators Transcription 153003448 Nonpathogen - LigA Anae109_0575 3 COG3047 OmpW, Outer membrane protein W Cell envelope biogenesis, outer membrane 153005301 Nonpathogen - hypothetical protein Anae109_2441 1 None None None 153002898 Common - OmpA/MotB domain protein Anae109_0019 164 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 153006160 Common - phospholipase D/Transphosphatidylase Anae109_3316 146 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 153006783 Nonpathogen - hypothetical protein Anae109_3946 2 None None None 153003365 Nonpathogen - hypothetical protein Anae109_0492 1 None None None 153006198 Common - two component transcriptional regulator, LuxR family Anae109_3355 141 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 153005876 Common - phosphonate ABC transporter, inner membrane subunit Anae109_3020 83 COG3639 COG3639, ABC-type phosphate/phosphonate transport system, permease component Inorganic ion transport and metabolism 153006030 Common - inner-membrane translocator Anae109_3175 108 COG1079 COG1079, Uncharacterized ABC-type transport system, permease component General function prediction only 153003816 Common - hypothetical protein Anae109_0948 11 None None None 153007111 Common - response regulator receiver protein Anae109_4274 124 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153006148 Common - Domain of unknown function DUF1814 Anae109_3302 5 COG2253 COG2253, Uncharacterized conserved protein Function unknown 153006385 Common - protein of unknown function zinc metallopeptidase putative Anae109_3545 86 COG2321 COG2321, Predicted metalloprotease General function prediction only 153003764 Common - ABC-2 type transporter Anae109_0896 106 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 153005792 Nonpathogen - hypothetical protein Anae109_2933 2 None None None 153004336 Common - Methyltransferase type 12 Anae109_1470 5 None None None 153005140 Nonpathogen - preprotein translocase, SecG subunit Anae109_2279 1 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 153007333 Common - ATP synthase F1, gamma subunit Anae109_4496 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 153007077 Common - putative flavoprotein Anae109_4240 59 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 153006474 Common - nitrogen regulatory protein P-II Anae109_3635 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 153002993 Nonpathogen - hypothetical protein Anae109_0116 1 None None None 153003051 Common - protein of unknown function DUF490 Anae109_0174 70 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 153003546 Nonpathogen - hypothetical protein Anae109_0674 2 COG4966 PilW, Tfp pilus assembly protein PilW Cell motility and secretion / Intracellular trafficking and secretion 153003581 Common - hypothetical protein Anae109_0709 6 None None None 153007235 Common - signal transduction histidine kinase, nitrogen specific, NtrB Anae109_4398 222 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 153006082 Common - histidine kinase Anae109_3228 217 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153004681 Nonpathogen - hypothetical protein Anae109_1819 1 None None None 153005590 Common - riboflavin synthase, alpha subunit Anae109_2730 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 153007100 Common - efflux transporter, RND family, MFP subunit Anae109_4263 133 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153006718 Common - UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase Anae109_3880 205 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 153006162 Common - hypothetical protein Anae109_3318 34 None None None 153003936 Nonpathogen - hypothetical protein Anae109_1069 1 None None None 153005751 Common - Patatin Anae109_2892 112 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 153006835 Nonpathogen - hypothetical protein Anae109_3998 10 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 153004485 Nonpathogen - hypothetical protein Anae109_1622 3 None None None 153004998 Common - acyl-CoA dehydrogenase domain protein Anae109_2136 167 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 153003926 Common - alpha/beta hydrolase fold Anae109_1059 99 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153005021 Common - LAO/AO transport system ATPase Anae109_2160 99 COG1703 ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family Amino acid transport and metabolism 153004795 Common - methionine aminopeptidase, type I Anae109_1933 230 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 153002943 Common - acetyl-CoA acetyltransferase Anae109_0064 172 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 153005701 Common - OmpA/MotB domain protein Anae109_2842 156 COG1360 MotB, Flagellar motor protein Cell motility and secretion 153003097 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Anae109_0220 123 COG0546 Gph, Predicted phosphatases General function prediction only 153003404 Common - MgtC/SapB transporter Anae109_0531 114 COG1285 SapB, Uncharacterized membrane protein Function unknown 153006573 Common - LrgB family protein Anae109_3735 84 COG1346 LrgB, Putative effector of murein hydrolase Cell envelope biogenesis, outer membrane 153006613 Common - protein kinase Anae109_3775 153 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 153003089 Common - pseudouridine synthase, RluA family Anae109_0212 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 153004568 Common - major facilitator superfamily MFS_1 Anae109_1705 129 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 153005046 Common - malate dehydrogenase, NAD-dependent Anae109_2185 189 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 153005459 Common - heavy metal translocating P-type ATPase Anae109_2599 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 153007009 Common - ABC transporter, inner membrane subunit Anae109_4172 41 COG4587 COG4587, ABC-type uncharacterized transport system, permease component General function prediction only 153005285 Common - methionine aminopeptidase, type I Anae109_2425 248 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 153003080 Common - Prephenate dehydrogenase Anae109_0203 137 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 153006431 Common - short-chain dehydrogenase/reductase SDR Anae109_3591 234 COG0623 FabI, Enoyl- acyl-carrier-protein 153005914 Common - hypothetical protein Anae109_3058 6 None None None 153006245 Common - Tol-Pal system YbgF Anae109_3402 77 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 153004337 Common - protein of unknown function DUF1025 Anae109_1471 40 COG3824 COG3824, Uncharacterized protein conserved in bacteria Function unknown 153005109 Common - iron dependent repressor Anae109_2248 68 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 153006777 Common - YceI family protein Anae109_3940 118 COG2353 COG2353, Uncharacterized conserved protein Function unknown 153005799 Nonpathogen - hypothetical protein Anae109_2940 4 None None None 153004362 Nonpathogen - response regulator receiver protein Anae109_1496 1 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153007238 Common - major facilitator superfamily MFS_1 Anae109_4401 21 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153006325 Common - maleylacetoacetate isomerase Anae109_3483 78 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 153007012 Common - hypothetical protein Anae109_4175 6 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 153006322 Nonpathogen - Methyltransferase type 11 Anae109_3479 1 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153003909 Common - TrkA-N domain protein Anae109_1041 162 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 153005769 Common - putative RNA methylase Anae109_2910 71 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 153005996 Nonpathogen - hypothetical protein Anae109_3141 1 None None None 153003668 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_0798 94 COG0348 NapH, Polyferredoxin Energy production and conversion 153006843 Nonpathogen - hypothetical protein Anae109_4006 1 None None None 153006875 Common - ATP dependent DNA ligase Anae109_4038 110 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 153006263 Common - ATP-dependent Clp protease, ATP-binding subunit ClpX Anae109_3420 227 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 153006670 Common - symporter Anae109_3832 159 COG4147 DhlC, Predicted symporter General function prediction only 153005451 Nonpathogen - hypothetical protein Anae109_2591 1 None None None 153005425 Nonpathogen - V-type ATP synthase, F subunit Anae109_2565 1 COG1436 NtpG, Archaeal/vacuolar-type H+-ATPase subunit F Energy production and conversion 153005508 Common - hypothetical protein Anae109_2648 10 None None None 153007070 Common - Patatin Anae109_4233 19 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 153004373 Common - protein of unknown function DUF62 Anae109_1507 72 COG1912 COG1912, Uncharacterized conserved protein Function unknown 153007159 Nonpathogen - hypothetical protein Anae109_4322 1 None None None 153005214 Common - tRNA cytidylyltransferase Anae109_2353 214 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 153005836 Nonpathogen - hypothetical protein Anae109_2978 2 None None None 153003634 Common - protein of unknown function DUF164 Anae109_0763 30 COG1579 COG1579, Zn-ribbon protein, possibly nucleic acid-binding General function prediction only 153003125 Common - hypothetical protein Anae109_0248 4 None None None 153004560 Common - extracellular solute-binding protein family 1 Anae109_1697 59 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 153006528 Nonpathogen - ParB domain protein nuclease Anae109_3690 2 None None None 153004747 Nonpathogen - hypothetical protein Anae109_1885 1 None None None 153004284 Common - D-alanine--D-alanine ligase Anae109_1418 211 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 153006791 Common - phosphoribosylformylglycinamidine synthase I Anae109_3954 214 COG0047 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain Nucleotide transport and metabolism 153005933 Common - putative transposase Anae109_3078 28 None None None 153006725 Common - D-alanine--D-alanine ligase Anae109_3887 212 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 153003723 Nonpathogen - hypothetical protein Anae109_0853 1 None None None 153006222 Common - Spore coat protein CotH Anae109_3379 9 COG5337 CotH, Spore coat assembly protein Cell envelope biogenesis, outer membrane 153007195 Nonpathogen - hypothetical protein Anae109_4358 3 COG1520 COG1520, FOG: WD40-like repeat Function unknown 153006067 Common - UDP-glucose 6-dehydrogenase Anae109_3213 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 153004107 Common - hypothetical protein Anae109_1240 25 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 153006256 Common - quinolinate synthetase complex, A subunit Anae109_3413 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 153004244 Common - tRNA pseudouridine synthase D TruD Anae109_1378 79 COG0585 COG0585, Uncharacterized conserved protein Function unknown 153003693 Nonpathogen - hypothetical protein Anae109_0823 1 None None None 153005881 Common - Ferredoxin III 4(4Fe-4S) nif-specific Anae109_3025 43 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 153005360 Nonpathogen - hypothetical protein Anae109_2500 2 None None None 153004567 Common - peptide chain release factor 3 Anae109_1704 249 COG4108 PrfC, Peptide chain release factor RF-3 Translation, ribosomal structure and biogenesis 153006395 Common - response regulator receiver protein Anae109_3555 149 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 153005439 Common - lipid A biosynthesis acyltransferase Anae109_2579 128 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 153004835 Common - peptidase M16 domain protein Anae109_1973 166 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 153005845 Nonpathogen - hypothetical protein Anae109_2987 1 None None None 153005653 Nonpathogen - hypothetical protein Anae109_2794 13 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 153005989 Common - peptidase M50 Anae109_3134 81 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 153006526 Nonpathogen - hypothetical protein Anae109_3688 1 None None None 153003220 Common - nucleoside recognition domain protein Anae109_0346 39 COG0700 SpmB, Uncharacterized membrane protein Function unknown 153004044 Common - ABC transporter related Anae109_1177 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 153003167 Nonpathogen - hypothetical protein Anae109_0291 1 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 153003821 Common - Hydroxylamine oxidase Anae109_0953 22 None None None 153004989 Common - Citrate transporter Anae109_2127 55 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 153006494 Common - short-chain dehydrogenase/reductase SDR Anae109_3655 201 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153005022 Nonpathogen - hypothetical protein Anae109_2161 2 None None None 153003582 Common - cell division ATP-binding protein FtsE Anae109_0710 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 153006591 Common - bifunctional deaminase-reductase domain protein Anae109_3753 72 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 153005801 Nonpathogen - hypothetical protein Anae109_2942 1 None None None 153007268 Common - ABC transporter related Anae109_4431 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 153006045 Common - PGAP1 family protein Anae109_3190 17 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 153006967 Common - hypothetical protein Anae109_4130 19 None None None 153004159 Common - NADH (or F420H2) dehydrogenase, subunit C Anae109_1292 175 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 153003474 Common - transcriptional regulator, Fis family Anae109_0601 168 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 153004071 Nonpathogen - mucin-associated surface protein (MASP), putative Anae109_1204 1 None None None 153006022 Common - helix-turn-helix- domain containing protein AraC type Anae109_3167 70 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 153003900 Common - Spermine synthase Anae109_1032 102 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 153006895 Common - zinc finger SWIM domain protein Anae109_4058 39 COG4279 COG4279, Uncharacterized conserved protein Function unknown 153003520 Common - CheD Anae109_0648 85 COG1871 CheD, Chemotaxis protein; stimulates methylation of MCP proteins Cell motility and secretion / Signal transduction mechanisms 153006531 Common - alpha/beta hydrolase fold Anae109_3693 120 COG2267 PldB, Lysophospholipase Lipid metabolism 153006651 Common - putative metalloendopeptidase, glycoprotease family Anae109_3813 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 153006953 Nonpathogen - LigA Anae109_4116 1 None None None 153006701 Common - ATPase, P-type (transporting), HAD superfamily, subfamily IC Anae109_3863 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 153002963 Nonpathogen - hypothetical protein Anae109_0084 3 None None None 153003277 Common - Rhodanese domain protein Anae109_0403 78 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 153004116 Common - AMP-dependent synthetase and ligase Anae109_1249 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153005824 Common - 4-alpha-glucanotransferase Anae109_2966 120 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 153006294 Nonpathogen - hypothetical protein Anae109_3451 1 None None None 153007131 Common - outer membrane efflux protein Anae109_4294 18 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 153007172 Nonpathogen - hypothetical protein Anae109_4335 1 None None None 153004653 Common - peptidase M48 Ste24p Anae109_1791 188 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 153003195 Nonpathogen - hypothetical protein Anae109_0320 1 None None None 153005840 Common - acriflavin resistance protein Anae109_2982 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 153003641 Common - primosomal protein N' Anae109_0770 211 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 153006690 Common - cyclic nucleotide-binding protein Anae109_3852 96 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 153004402 Common - ABC-3 protein Anae109_1537 20 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 153007108 Common - hypothetical protein Anae109_4271 2 None None None 153006858 Common - dual specificity protein phosphatase Anae109_4021 17 COG2453 CDC14, Predicted protein-tyrosine phosphatase Signal transduction mechanisms 153005245 Nonpathogen - hypothetical protein Anae109_2384 3 None None None 153003143 Common - response regulator receiver Anae109_0266 206 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 153006784 Nonpathogen - mucin-associated surface protein (MASP), putative Anae109_3947 1 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 153003795 Common - sodium/hydrogen exchanger Anae109_0927 96 COG3263 COG3263, NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain Inorganic ion transport and metabolism 153006112 Common - SAM-dependent methyltransferase Anae109_3260 7 None None None 153005321 Common - PfkB domain protein Anae109_2461 195 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 153005410 Nonpathogen - hypothetical protein Anae109_2550 6 None None None 153002885 Nonpathogen - peptidase zinc-dependent Anae109_0006 22 COG1913 COG1913, Predicted Zn-dependent proteases General function prediction only 153003270 Common - ApaG domain protein Anae109_0396 89 COG2967 ApaG, Uncharacterized protein affecting Mg2+/Co2+ transport Inorganic ion transport and metabolism 153007088 Common - multi-sensor signal transduction histidine kinase Anae109_4251 166 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 153002925 Common - NAD-dependent epimerase/dehydratase Anae109_0046 33 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153005235 Common - Co/Zn/Cd efflux system component Anae109_2374 61 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 153004502 Common - sulfate ABC transporter, ATPase subunit Anae109_1639 249 COG1118 CysA, ABC-type sulfate/molybdate transport systems, ATPase component Inorganic ion transport and metabolism 153004586 Nonpathogen - BFD domain protein (2Fe-2S)-binding domain protein Anae109_1723 1 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 153005588 Common - 6,7-dimethyl-8-ribityllumazine synthase Anae109_2728 230 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 153006060 Common - aldo/keto reductase Anae109_3206 197 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 153005089 Common - ribosomal protein L33 Anae109_2228 32 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 153003383 Common - bifunctional deaminase-reductase domain protein Anae109_0510 25 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 153003591 Common - chromosome segregation protein SMC Anae109_0719 177 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 153006250 Common - extracellular solute-binding protein family 5 Anae109_3407 7 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 153004175 Nonpathogen - protein of unknown function DUF147 Anae109_1308 29 COG1624 COG1624, Uncharacterized conserved protein Function unknown 153006975 Nonpathogen - transcriptional antiterminator, BglG Anae109_4138 1 COG3711 BglG, Transcriptional antiterminator Transcription 153003084 Common - Shikimate kinase Anae109_0207 151 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 153006019 Common - GCN5-related N-acetyltransferase Anae109_3164 152 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 153007145 Nonpathogen - 4Fe-4S ferredoxin iron-sulfur binding domain protein Anae109_4308 32 COG1148 HdrA, Heterodisulfide reductase, subunit A and related polyferredoxins Energy production and conversion 153006413 Nonpathogen - hypothetical protein Anae109_3573 3 None None None 153003846 Common - glycerophosphoryl diester phosphodiesterase Anae109_0978 152 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 153005574 Nonpathogen - hypothetical protein Anae109_2714 10 None None None 153004072 Common - Methyltransferase type 11 Anae109_1205 13 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153006923 Common - putative ribonuclease BN Anae109_4086 78 COG1295 Rbn, Predicted membrane protein Function unknown 153005820 Common - protein of unknown function DUF955 Anae109_2962 47 COG3800 COG3800, Predicted transcriptional regulator General function prediction only 153004366 Common - phage SPO1 DNA polymerase-related protein Anae109_1500 160 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 153005280 Nonpathogen - hypothetical protein Anae109_2420 1 None None None 153005478 Common - polysaccharide export protein Anae109_2618 116 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 153006571 Nonpathogen - Os11g0538400 Anae109_3733 1 None None None 153005190 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Anae109_2329 105 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 153005060 Nonpathogen - hypothetical protein Anae109_2199 1 None None None 153006630 Common - putative nicotinate phosphoribosyltransferase Anae109_3792 109 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 153004057 Common - aldehyde dehydrogenase Anae109_1190 18 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 153007186 Common - NADH-quinone oxidoreductase, E subunit Anae109_4349 157 COG1905 NuoE, NADH:ubiquinone oxidoreductase 24 kD subunit Energy production and conversion 153003529 Common - CheA signal transduction histidine kinase Anae109_0657 199 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 153003050 Common - surface antigen (D15) Anae109_0173 132 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 153006513 Common - hypothetical protein Anae109_3674 18 COG4683 COG4683, Uncharacterized protein conserved in bacteria Function unknown 153003504 Common - arginine biosynthesis bifunctional protein ArgJ Anae109_0632 219 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 153004330 Common - nicotinate (nicotinamide) nucleotide adenylyltransferase Anae109_1464 180 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 153004807 Common - ribosomal protein L19 Anae109_1945 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 153005094 Common - chaperone protein DnaK Anae109_2233 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 153007247 Common - sulfate ABC transporter, periplasmic sulfate-binding protein Anae109_4410 95 COG1613 Sbp, ABC-type sulfate transport system, periplasmic component Inorganic ion transport and metabolism 153003182 Common - protein of unknown function DUF1458 Anae109_0307 11 COG3360 COG3360, Uncharacterized conserved protein Function unknown 153003476 Common - hypothetical protein Anae109_0603 6 COG3832 COG3832, Uncharacterized conserved protein Function unknown 153005601 Common - ribosomal protein L32 Anae109_2741 14 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 153003486 Common - putative GAF sensor protein Anae109_0614 197 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153004571 Common - peptidase M48 Ste24p Anae109_1708 177 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 153006175 Common - Carbohydrate binding family 6 Anae109_3332 17 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 153004049 Common - hypothetical protein Anae109_1182 9 None None None 153004648 Common - CsbD family protein Anae109_1786 5 None None None 153005558 Common - diguanylate cyclase Anae109_2698 156 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153004837 Common - hypothetical protein Anae109_1975 9 None None None 153004841 Nonpathogen - hypothetical protein Anae109_1979 1 None None None 153003954 Nonpathogen - hypothetical protein Anae109_1087 1 None None None 153007218 Nonpathogen - hypothetical protein Anae109_4381 1 None None None 153004376 Common - AMP-dependent synthetase and ligase Anae109_1510 211 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 153005537 Common - MaoC domain protein dehydratase Anae109_2677 55 COG2030 MaoC, Acyl dehydratase Lipid metabolism 153004616 Common - 3-isopropylmalate dehydrogenase Anae109_1754 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 153004614 Common - hypothetical protein Anae109_1752 32 None None None 153004039 Nonpathogen - protein of unknown function DUF6 transmembrane Anae109_1172 7 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 153003047 Common - MotA/TolQ/ExbB proton channel Anae109_0170 151 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 153004698 Common - cytochrome C family protein Anae109_1836 29 None None None 153006968 Common - RES domain protein Anae109_4131 20 None None None 153004223 Common - UvrD/REP helicase Anae109_1357 141 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 153006204 Common - helix-turn-helix- domain containing protein AraC type Anae109_3361 152 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 153003751 Common - protein of unknown function DUF1470 Anae109_0883 16 COG5516 COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding General function prediction only 153005420 Common - PAS/PAC sensor signal transduction histidine kinase Anae109_2560 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153005675 Nonpathogen - protein of unknown function DUF6 transmembrane Anae109_2816 6 None None None 153003733 Common - molybdopterin oxidoreductase Fe4S4 region Anae109_0863 145 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 153007029 Nonpathogen - hypothetical protein Anae109_4192 2 COG4907 COG4907, Predicted membrane protein Function unknown 153003376 Nonpathogen - hypothetical protein Anae109_0503 5 None None None 153004257 Nonpathogen - hypothetical protein Anae109_1391 2 None None None 153006188 Nonpathogen - hypothetical protein Anae109_3345 14 None None None 153003069 Common - sulfatase Anae109_0192 37 COG3083 COG3083, Predicted hydrolase of alkaline phosphatase superfamily General function prediction only 153007179 Common - cell divisionFtsK/SpoIIIE Anae109_4342 198 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 153003424 Common - S1/P1 nuclease Anae109_0551 20 None None None 153005977 Common - ABC transporter related Anae109_3122 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 153004620 Nonpathogen - hypothetical protein Anae109_1758 1 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 153004693 Common - hypothetical protein Anae109_1831 34 COG3391 COG3391, Uncharacterized conserved protein Function unknown 153006010 Common - Endothelin-converting enzyme 1 Anae109_3155 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 153004788 Common - ribosomal protein L6 Anae109_1926 238 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 153004008 Common - translation initiation factor IF-2 Anae109_1141 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 153004522 Nonpathogen - hypothetical protein Anae109_1659 1 None None None 153006641 Common - Phosphoenolpyruvate carboxykinase (GTP) Anae109_3803 59 COG1274 PckA, Phosphoenolpyruvate carboxykinase (GTP) Energy production and conversion 153003016 Common - glycogen/starch synthase, ADP-glucose type Anae109_0139 139 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 153004065 Nonpathogen - hypothetical protein Anae109_1198 2 COG4907 COG4907, Predicted membrane protein Function unknown 153005958 Common - GAF sensor signal transduction histidine kinase Anae109_3103 215 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 153004476 Common - Spermine synthase Anae109_1613 16 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 153004689 Nonpathogen - cytochrome C family protein Anae109_1827 2 None None None 153003174 Common - formamidopyrimidine-DNA glycosylase Anae109_0299 181 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 153006257 Nonpathogen - hypothetical protein Anae109_3414 1 None None None 153003850 Common - cytochrome bd ubiquinol oxidase subunit II Anae109_0982 133 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 153005713 Common - metallophosphoesterase Anae109_2854 18 COG1409 Icc, Predicted phosphohydrolases General function prediction only 153004468 Nonpathogen - FxsA-like protein Anae109_1605 2 COG3030 FxsA, Protein affecting phage T7 exclusion by the F plasmid General function prediction only 153005041 Common - radical SAM enzyme, Cfr family Anae109_2180 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 153003393 Nonpathogen - hypothetical protein Anae109_0520 1 None None None 153004642 Common - phosphoglucomutase, alpha-D-glucose phosphate-specific Anae109_1780 238 COG0033 Pgm, Phosphoglucomutase Carbohydrate transport and metabolism 153005516 Common - Resolvase domain Anae109_2656 14 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 153005726 Nonpathogen - hypothetical protein Anae109_2867 1 None None None 153006106 Common - transcriptional regulator, TetR family Anae109_3254 86 COG1309 AcrR, Transcriptional regulator Transcription 153003160 Common - protein of unknown function UPF0044 Anae109_0283 98 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 153005014 Common - Pyrrolo-quinoline quinone Anae109_2153 115 COG1520 COG1520, FOG: WD40-like repeat Function unknown 153002934 Common - MltA domain protein Anae109_0055 93 COG2821 MltA, Membrane-bound lytic murein transglycosylase Cell envelope biogenesis, outer membrane 153004148 Common - proton-translocating NADH-quinone oxidoreductase, chain L Anae109_1281 208 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 153007290 Common - adventurous gliding motility protein S Anae109_4453 6 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 153005929 Nonpathogen - hypothetical protein Anae109_3074 1 None None None 153006281 Common - peptidase M28 Anae109_3438 13 COG2234 Iap, Predicted aminopeptidases General function prediction only 153007319 Common - 4-hydroxythreonine-4-phosphate dehydrogenase Anae109_4482 158 COG1995 PdxA, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 153005345 Common - Inorganic diphosphatase Anae109_2485 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 153004783 Common - ribosomal protein L14 Anae109_1921 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 153003913 Common - efflux transporter, RND family, MFP subunit Anae109_1045 68 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 153006300 Common - hypothetical protein Anae109_3457 15 None None None 153006136 Common - IstB domain protein ATP-binding protein Anae109_3288 105 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 153003615 Nonpathogen - type III secretion system inner membrane R protein Anae109_0743 1 COG4791 EscT, Type III secretory pathway, component EscT Intracellular trafficking and secretion 153005059 Common - ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent Anae109_2198 203 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 153006697 Common - FHA domain containing protein Anae109_3859 44 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 153006366 Common - thiamineS Anae109_3526 11 None None None 153004599 Common - Cys/Met metabolism pyridoxal-phosphate-dependent protein Anae109_1737 204 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 153006229 Common - TPR repeat-containing protein Anae109_3386 15 COG4105 ComL, DNA uptake lipoprotein General function prediction only 153002942 Common - Sec-independent protein translocase, TatC subunit Anae109_0063 205 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 153005082 Common - DNA-directed RNA polymerase, beta subunit Anae109_2221 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 153006940 Nonpathogen - FeoA family protein Anae109_4103 3 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 153004513 Nonpathogen - hypothetical protein Anae109_1650 3 None None None 153006216 Nonpathogen - putative lipoprotein Anae109_3373 2 None None None 153005354 Common - putative cold-shock DNA-binding domain protein Anae109_2494 181 COG1278 CspC, Cold shock proteins Transcription 153003229 Common - Dihydrodipicolinate reductase Anae109_0355 212 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 153003451 Nonpathogen - hypothetical protein Anae109_0578 1 None None None 153003568 Common - Tetratricopeptide TPR_2 repeat protein Anae109_0696 29 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 153006992 Common - proton-translocating NADH-quinone oxidoreductase, chain M Anae109_4155 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 153006538 Common - domain of unknown function DUF1731 Anae109_3700 107 COG1090 COG1090, Predicted nucleoside-diphosphate sugar epimerase General function prediction only 153003819 Common - phosphopentomutase Anae109_0951 71 COG1015 DeoB, Phosphopentomutase Carbohydrate transport and metabolism 153005497 Nonpathogen - histidine kinase HAMP region domain protein Anae109_2637 1 None None None 153005383 Common - glycine cleavage system H protein Anae109_2523 188 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 153006487 Common - redox-active disulfide protein 2 Anae109_3648 58 None None None 153004272 Common - ABC transporter related Anae109_1406 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 153004948 Common - Glucose-6-phosphate isomerase Anae109_2086 109 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 153005526 Common - protein of unknown function DUF1452 Anae109_2666 26 COG5478 COG5478, Predicted small integral membrane protein Function unknown 153004389 Common - inosine-5'-monophosphate dehydrogenase Anae109_1524 241 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 153003801 Common - OmpA/MotB domain protein Anae109_0933 127 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 153003460 Nonpathogen - hypothetical protein Anae109_0587 9 None None None 153004754 Common - thiamine pyrophosphate protein domain protein TPP-binding Anae109_1892 113 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 153005554 Common - DNA protecting protein DprA Anae109_2694 209 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 153005870 Common - hypothetical protein Anae109_3014 19 COG5373 COG5373, Predicted membrane protein Function unknown 153005274 Nonpathogen - hypothetical protein Anae109_2414 1 None None None 153004202 Common - peptide methionine sulfoxide reductase Anae109_1335 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 153006637 Common - peptidase M23B Anae109_3799 175 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 153006916 Common - squalene-hopene cyclase Anae109_4079 40 COG1657 SqhC, Squalene cyclase Lipid metabolism 153007299 Common - response regulator receiver protein Anae109_4462 224 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 153004898 Nonpathogen - hypothetical protein Anae109_2036 1 None None None 153004185 Common - SpoIID/LytB domain Anae109_1318 45 COG2385 SpoIID, Sporulation protein and related proteins Cell division and chromosome partitioning 153004434 Nonpathogen - hypothetical protein Anae109_1571 1 None None None 153006021 Common - Electron transfer flavoprotein alpha/beta-subunit Anae109_3166 151 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 153005364 Common - Adenylosuccinate synthase Anae109_2504 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 153004060 Common - helix-turn-helix domain protein Anae109_1193 63 COG1813 COG1813, Predicted transcription factor, homolog of eukaryotic MBF1 Transcription 153005315 Common - DNA polymerase I Anae109_2455 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 153003453 Common - DGPFAETKE family protein Anae109_0580 40 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 153004214 Nonpathogen - hypothetical protein Anae109_1347 1 None None None 153005606 Common - hypothetical protein Anae109_2746 20 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 153007148 Common - sigma 54 modulation protein/ribosomal protein S30EA Anae109_4311 170 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 153005748 Nonpathogen - hypothetical protein Anae109_2889 2 COG1041 COG1041, Predicted DNA modification methylase DNA replication, recombination, and repair 153003569 Common - general secretion pathway protein-related protein Anae109_0697 65 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 153003882 Common - phosphoribosyltransferase Anae109_1014 68 COG1926 COG1926, Predicted phosphoribosyltransferases General function prediction only 153004144 Common - transcriptional regulator, BadM/Rrf2 family Anae109_1277 183 COG1959 COG1959, Predicted transcriptional regulator Transcription