Kineococcus radiotolerans SRS30216, complete genome NC_009664 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 152964875 Common - protein of unknown function UPF0118 Krad_0907 131 COG0628 PerM, Predicted permease General function prediction only 152967744 Common - hypothetical protein Krad_3801 8 COG4963 CpaE, Flp pilus assembly protein, ATPase CpaE Intracellular trafficking and secretion 152964973 Common - major facilitator superfamily MFS_1 Krad_1005 25 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152964811 Nonpathogen - hypothetical protein Krad_0843 1 None None None 152965804 Common - protein of unknown function DUF124 Krad_1838 14 COG2013 COG2013, Uncharacterized conserved protein Function unknown 152964727 Common - alpha/beta hydrolase fold Krad_0758 67 COG2267 PldB, Lysophospholipase Lipid metabolism 152968238 Common - hypothetical protein Krad_4295 19 None None None 152965795 Common - acetyltransferase-like protein Krad_1829 30 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 152965322 Common - fumarylacetoacetate (FAA) hydrolase Krad_1354 179 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 152966981 Common - integral membrane sensor signal transduction histidine kinase Krad_3037 204 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152964955 Common - Phosphoglycerate mutase Krad_0987 13 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 152966914 Common - hypothetical protein Krad_2970 15 None None None 152963987 Nonpathogen - virulence factor MVIN family protein Krad_0015 2 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 152964186 Common - conserved hypothetical protein; putative adenylate cyclase domain Krad_0215 11 COG5607 COG5607, Uncharacterized conserved protein Function unknown 152966700 Common - binding-protein-dependent transport systems inner membrane component Krad_2748 204 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 152964720 Common - putative transcriptional regulator, GntR family Krad_0751 193 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 152968166 Common - transcriptional regulator, MarR family Krad_4223 5 COG1846 MarR, Transcriptional regulators Transcription 152966982 Nonpathogen - hypothetical protein Krad_3038 1 None None None 152965490 Common - transcriptional regulator, GntR family Krad_1522 133 COG1802 GntR, Transcriptional regulators Transcription 152967731 Common - type II secretion system protein Krad_3788 8 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 152964150 Common - diguanylate cyclase/phosphodiesterase with GAF sensor Krad_0179 160 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152964246 Common - Inositol 2-dehydrogenase Krad_0276 98 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152964648 Common - ribosomal protein L7/L12 Krad_0679 214 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 152966122 Common - PfkB domain protein Krad_2158 89 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 152968099 Common - Inositol 2-dehydrogenase Krad_4156 79 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152965095 Common - binding-protein-dependent transport systems inner membrane component Krad_1127 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 152964227 Common - hypothetical protein Krad_0257 9 None None None 152964514 Common - glycosyl transferase group 1 Krad_0545 127 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152965329 Common - EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) Krad_1361 208 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 152967764 Common - ABC transporter-related protein Krad_3821 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 152965551 Common - uroporphyrinogen decarboxylase Krad_1585 174 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 152964502 Common - urea amidolyase related protein Krad_0533 115 COG1984 DUR1, Allophanate hydrolase subunit 2 Amino acid transport and metabolism 152967632 Common - UTP-glucose-1-phosphate uridylyltransferase Krad_3689 232 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 152967713 Common - Tellurite resistance TerB Krad_3770 16 COG3793 TerB, Tellurite resistance protein Inorganic ion transport and metabolism 152964220 Common - HAD-superfamily hydrolase, subfamily IIB Krad_0250 102 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 152966587 Nonpathogen - hypothetical protein Krad_2635 1 None None None 152967420 Common - Rhodanese domain protein Krad_3477 40 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152967504 Common - GCN5-related N-acetyltransferase Krad_3561 11 COG0456 RimI, Acetyltransferases General function prediction only 152967935 Nonpathogen - hypothetical protein Krad_3992 1 None None None 152964000 Common - hypothetical protein Krad_0028 4 None None None 152964681 Common - ribosomal protein L36 Krad_0712 127 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 152964782 Common - hypothetical protein Krad_0814 6 None None None 152964472 Common - transcriptional regulator, XRE family Krad_0503 44 COG1476 COG1476, Predicted transcriptional regulators Transcription 152964604 Common - 1,4-dihydroxy-2-naphthoate octaprenyltransferase Krad_0635 68 COG1575 MenA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase Coenzyme metabolism 152966154 Common - protein of unknown function DUF1330 Krad_2191 7 COG5470 COG5470, Uncharacterized conserved protein Function unknown 152964382 Common - Beta-galactosidase Krad_0412 39 COG1874 LacA, Beta-galactosidase Carbohydrate transport and metabolism 152967067 Common - cell divisionFtsK/SpoIIIE Krad_3123 196 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 152964699 Common - alpha/beta hydrolase fold Krad_0730 61 COG1647 COG1647, Esterase/lipase General function prediction only 152966458 Common - condensation domain protein Krad_2503 3 COG4908 COG4908, Uncharacterized protein containing a NRPS condensation (elongation) domain General function prediction only 152967823 Nonpathogen - putative conserved membrane protein Krad_3880 1 None None None 152967843 Common - UDP-glucose 6-dehydrogenase Krad_3900 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 152967609 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Krad_3666 209 COG0313 COG0313, Predicted methyltransferases General function prediction only 152966337 Nonpathogen - hypothetical protein Krad_2377 1 None None None 152967570 Common - hypothetical protein Krad_3627 8 COG4270 COG4270, Predicted membrane protein Function unknown 152965436 Common - Dihydrodipicolinate reductase Krad_1468 205 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 152965338 Nonpathogen - hypothetical protein Krad_1370 1 None None None 152967639 Common - diguanylate cyclase/phosphodiesterase Krad_3696 175 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152965571 Common - formate/nitrite transporter Krad_1605 102 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 152966049 Common - hypothetical protein Krad_2084 28 COG4188 COG4188, Predicted dienelactone hydrolase General function prediction only 152966167 Common - hypothetical protein Krad_2206 9 COG4188 COG4188, Predicted dienelactone hydrolase General function prediction only 152965420 Common - deoxyxylulose-5-phosphate synthase Krad_1452 205 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 152966443 Common - Asp/Glu racemase Krad_2487 7 COG1794 RacX, Aspartate racemase Cell envelope biogenesis, outer membrane 152967930 Common - magnesium and cobalt transport protein CorA Krad_3987 155 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 152967369 Nonpathogen - LmbE family protein Krad_3426 3 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 152965564 Nonpathogen - protein of unknown function DUF322 Krad_1598 1 COG1302 COG1302, Uncharacterized protein conserved in bacteria Function unknown 152968183 Common - NAD-dependent epimerase/dehydratase Krad_4240 91 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152964634 Common - MaoC domain protein dehydratase Krad_0665 53 COG2030 MaoC, Acyl dehydratase Lipid metabolism 152968066 Nonpathogen - anti-sigma-factor antagonist Krad_4123 1 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 152966473 Common - two component transcriptional regulator, LuxR family Krad_2518 198 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152967917 Nonpathogen - hypothetical protein Krad_3974 1 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 152968395 Common - transcriptional regulator, TetR family Krad_4456 15 COG1309 AcrR, Transcriptional regulator Transcription 152964663 Common - ribosomal protein S3 Krad_0694 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 152968243 Common - diguanylate cyclase Krad_4300 151 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152964999 Common - putative D-amino acid deaminase Krad_1031 48 COG3616 COG3616, Predicted amino acid aldolase or racemase Amino acid transport and metabolism 152966294 Nonpathogen - hypothetical protein Krad_2334 1 None None None 152964008 Common - diguanylate cyclase Krad_0036 9 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152966091 Common - transcriptional regulator, GntR family Krad_2127 127 COG1802 GntR, Transcriptional regulators Transcription 152967134 Common - transcriptional regulator, TraR/DksA family Krad_3190 64 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 152964988 Common - two component transcriptional regulator, winged helix family Krad_1020 196 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152964264 Common - Formamidopyrimidine-DNA glycolase Krad_0294 134 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 152966017 Nonpathogen - hypothetical protein Krad_2052 1 None None None 152966631 Nonpathogen - hypothetical protein Krad_2679 1 None None None 152964412 Common - transport system permease protein Krad_0442 184 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 152966811 Common - NAD-dependent epimerase/dehydratase Krad_2865 123 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152964302 Common - response regulator receiver protein Krad_0332 224 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152968261 Common - transcriptional regulator, TetR family Krad_4318 6 COG1309 AcrR, Transcriptional regulator Transcription 152967775 Common - peptidase S9 prolyl oligopeptidase active site domain protein Krad_3832 101 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 152964963 Nonpathogen - hypothetical protein Krad_0995 1 None None None 152965451 Common - hypothetical protein Krad_1483 5 None None None 152964363 Common - SCP-like extracellular protein Krad_0393 38 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 152968208 Common - permease for cytosine/purines uracil thiamine allantoin Krad_4265 49 COG1953 FUI1, Cytosine/uracil/thiamine/allantoin permeases Nucleotide transport and metabolism / Coenzyme metabolism 152967477 Common - transcriptional regulator, HxlR family Krad_3534 141 COG1733 COG1733, Predicted transcriptional regulators Transcription 152966836 Nonpathogen - hypothetical protein Krad_2891 3 None None None 152964694 Common - holo-acyl-carrier-protein synthase Krad_0725 18 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 152967427 Common - cysteine desulfurase, SufS subfamily Krad_3484 234 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 152966347 Nonpathogen - hypothetical protein Krad_2387 1 None None None 152967689 Common - regulatory protein LacI Krad_3746 31 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152966452 Common - Alcohol dehydrogenase GroES domain protein Krad_2496 137 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 152965259 Common - binding-protein-dependent transport systems inner membrane component Krad_1291 133 COG1174 OpuBB, ABC-type proline/glycine betaine transport systems, permease component Amino acid transport and metabolism 152967717 Common - protein of unknown function DUF179 Krad_3774 127 COG1678 COG1678, Putative transcriptional regulator Transcription 152964554 Common - Oxidoreductase domain protein Krad_0585 41 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152964791 Common - PRC-barrel domain protein Krad_0823 9 COG3861 COG3861, Uncharacterized protein conserved in bacteria Function unknown 152967810 Nonpathogen - hypothetical protein Krad_3867 1 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 152966898 Common - ABC transporter-related protein Krad_2954 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 152966424 Nonpathogen - hypothetical protein Krad_2468 1 None None None 152967592 Nonpathogen - hypothetical protein Krad_3649 1 None None None 152965587 Common - flagellar hook-associated protein 3 Krad_1621 98 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 152966390 Nonpathogen - hypothetical protein Krad_2430 1 None None None 152964319 Common - OsmC family protein Krad_0349 13 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 152966175 Nonpathogen - hypothetical protein Krad_2214 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 152966878 Common - uncharacterised P-loop ATPase protein UPF0042 Krad_2934 140 COG1660 COG1660, Predicted P-loop-containing kinase General function prediction only 152968345 Common - ADP-ribosylation/Crystallin J1 Krad_4406 76 COG1397 DraG, ADP-ribosylglycohydrolase Posttranslational modification, protein turnover, chaperones 152966682 Common - hypothetical protein Krad_2730 31 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152966675 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Krad_2723 176 COG0388 COG0388, Predicted amidohydrolase General function prediction only 152964881 Common - transcriptional regulator, MarR family Krad_0913 22 COG1846 MarR, Transcriptional regulators Transcription 152968155 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Krad_4212 161 COG0388 COG0388, Predicted amidohydrolase General function prediction only 152963991 Common - glycosyl transferase group 1 Krad_0019 60 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152964257 Common - ribosomal protein L28 Krad_0287 141 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 152965737 Nonpathogen - hypothetical protein Krad_1771 1 None None None 152965444 Common - Alcohol dehydrogenase GroES domain protein Krad_1476 142 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 152964926 Common - helix-turn-helix- domain containing protein AraC type Krad_0958 65 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 152964015 Common - NADH dehydrogenase (quinone) Krad_0044 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 152965670 Nonpathogen - hypothetical protein Krad_1704 1 None None None 152968120 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Krad_4177 49 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 152967006 Common - glycosyl transferase group 1 Krad_3062 186 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152965224 Common - ribosomal protein L31 Krad_1256 136 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 152964103 Common - phage shock protein C, PspC Krad_0132 4 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 152968146 Common - Mannitol dehydrogenase rossman domain Krad_4203 63 COG0246 MtlD, Mannitol-1-phosphate/altronate dehydrogenases Carbohydrate transport and metabolism 152967443 Common - formate/nitrite family of transporters-like protein Krad_3500 2 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 152966891 Common - regulatory protein LacI Krad_2947 123 COG1609 PurR, Transcriptional regulators Transcription 152965163 Common - metallophosphoesterase Krad_1195 106 COG4639 COG4639, Predicted kinase General function prediction only 152964249 Common - phage shock protein C, PspC Krad_0279 4 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 152966303 Nonpathogen - hypothetical protein Krad_2343 1 None None None 152964460 Common - DNA polymerase III, delta prime subunit Krad_0490 214 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 152966094 Common - major facilitator superfamily MFS_1 Krad_2130 133 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152966264 Common - aldo/keto reductase Krad_2303 203 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152966385 Nonpathogen - hypothetical protein Krad_2425 1 None None None 152965247 Common - putative cellulose-binding protein Krad_1279 11 COG2268 COG2268, Uncharacterized protein conserved in bacteria Function unknown 152966862 Common - putative transcriptional regulator Krad_2918 15 COG2345 COG2345, Predicted transcriptional regulator Transcription 152964886 Common - sodium/hydrogen exchanger Krad_0918 32 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 152967910 Common - ribonuclease BN Krad_3967 8 COG1295 Rbn, Predicted membrane protein Function unknown 152967400 Common - ribosomal protein L21 Krad_3457 195 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 152966597 Nonpathogen - hypothetical protein Krad_2645 1 None None None 152968055 Common - Chorismate synthase Krad_4112 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 152964285 Common - putative CheW protein Krad_0315 123 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 152966366 Common - hypothetical protein Krad_2406 19 COG5500 COG5500, Predicted integral membrane protein Function unknown 152964389 Common - Bile acid:sodium symporter Krad_0419 74 COG0385 COG0385, Predicted Na+-dependent transporter General function prediction only 152965720 Nonpathogen - hypothetical protein Krad_1754 1 None None None 152966818 Common - NAD-dependent epimerase/dehydratase Krad_2872 106 COG1090 COG1090, Predicted nucleoside-diphosphate sugar epimerase General function prediction only 152964362 Common - diguanylate cyclase with PAS/PAC sensor Krad_0392 188 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152965252 Common - beta-lactamase Krad_1284 86 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 152966871 Common - electron transport protein Krad_2927 19 None None None 152967035 Common - Cobyrinic acid ac-diamide synthase Krad_3091 123 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 152967695 Nonpathogen - hypothetical protein Krad_3752 1 None None None 152966794 Nonpathogen - hypothetical protein Krad_2847 1 None None None 152965652 Nonpathogen - hypothetical protein Krad_1686 1 None None None 152966654 Common - transcriptional regulator, DeoR family Krad_2702 111 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 152967965 Nonpathogen - hypothetical protein Krad_4022 1 None None None 152968173 Common - putative transcriptional regulator, MerR family Krad_4230 38 COG0789 SoxR, Predicted transcriptional regulators Transcription 152965358 Common - chromosome segregation protein SMC Krad_1390 176 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 152968082 Common - hypothetical protein Krad_4139 8 None None None 152967662 Common - protein of unknown function DUF202 Krad_3719 9 COG2149 COG2149, Predicted membrane protein Function unknown 152966269 Common - low temperature requirement A Krad_2308 16 COG4292 COG4292, Predicted membrane protein Function unknown 152967621 Common - glycosyl transferase family 2 Krad_3678 73 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 152967978 Common - transcriptional regulator, XRE family Krad_4035 41 COG1396 HipB, Predicted transcriptional regulators Transcription 152968059 Common - Cna B domain protein Krad_4116 54 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 152964742 Nonpathogen - Phytanoyl-CoA dioxygenase Krad_0774 6 COG5285 COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin Secondary metabolites biosynthesis, transport, and catabolism 152964981 Common - Non-specific serine/threonine protein kinase Krad_1013 127 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 152965111 Common - succinyl-diaminopimelate desuccinylase Krad_1143 99 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 152966997 Common - Holliday junction DNA helicase RuvB Krad_3053 216 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 152966783 Nonpathogen - hypothetical protein Krad_2835 1 None None None 152967211 Common - major facilitator superfamily MFS_1 Krad_3267 172 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152965736 Nonpathogen - hypothetical protein Krad_1770 1 None None None 152966270 Common - NADP oxidoreductase coenzyme F420-dependent Krad_2309 38 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 152964684 Common - DNA-directed RNA polymerase, alpha subunit Krad_0715 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 152967344 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_3400 30 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152964127 Common - putative signal transduction histidine kinase Krad_0156 7 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 152964494 Common - putative transcriptional regulator, MerR family Krad_0525 140 COG0789 SoxR, Predicted transcriptional regulators Transcription 152966569 Nonpathogen - hypothetical protein Krad_2616 1 None None None 152964610 Common - naphthoate synthase Krad_0641 177 COG0447 MenB, Dihydroxynaphthoic acid synthase Coenzyme metabolism 152966181 Common - NAD-dependent epimerase/dehydratase Krad_2220 54 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152967284 Common - 2-oxo-acid dehydrogenase E1 subunit, homodimeric type Krad_3340 154 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 152967983 Common - phosphoribosylformylglycinamidine cyclo-ligase Krad_4040 227 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 152965195 Common - lipolytic protein G-D-S-L family Krad_1227 16 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 152967010 Common - threonyl-tRNA synthetase Krad_3066 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152965136 Common - hypothetical protein Krad_1168 9 COG1913 COG1913, Predicted Zn-dependent proteases General function prediction only 152965641 Nonpathogen - type IV pilus assembly PilZ Krad_1675 2 None None None 152966439 Common - fructose-1,6-bisphosphatase, class II Krad_2483 112 COG1494 GlpX, Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins Carbohydrate transport and metabolism 152965902 Common - low temperature requirement A Krad_1936 12 COG4292 COG4292, Predicted membrane protein Function unknown 152965881 Common - putative transcriptional regulator, MerR family Krad_1915 67 COG0789 SoxR, Predicted transcriptional regulators Transcription 152967137 Common - protein of unknown function DUF552 Krad_3193 51 COG1799 COG1799, Uncharacterized protein conserved in bacteria Function unknown 152967530 Common - transcriptional regulator, MarR family Krad_3587 62 COG1846 MarR, Transcriptional regulators Transcription 152965154 Common - periplasmic binding protein/LacI transcriptional regulator Krad_1186 81 COG4213 XylF, ABC-type xylose transport system, periplasmic component Carbohydrate transport and metabolism 152966851 Common - hypothetical protein Krad_2907 26 COG3346 COG3346, Uncharacterized conserved protein Function unknown 152964807 Common - UspA domain protein Krad_0839 5 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 152964370 Common - hypothetical protein Krad_0400 8 COG2353 COG2353, Uncharacterized conserved protein Function unknown 152967300 Nonpathogen - hypothetical protein Krad_3356 1 None None None 152964994 Common - diguanylate cyclase/phosphodiesterase Krad_1026 172 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152966321 Nonpathogen - hypothetical protein Krad_2361 1 None None None 152966064 Common - helix-turn-helix- domain containing protein AraC type Krad_2099 78 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 152966327 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_2367 84 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152964116 Common - extracellular solute-binding protein family 5 Krad_0145 197 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 152964469 Common - protein tyrosine phosphatase Krad_0500 83 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 152968201 Common - Endopeptidase Clp Krad_4258 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 152965986 Nonpathogen - hypothetical protein Krad_2021 1 None None None 152965379 Common - RNA polymerase, sigma 28 subunit, FliA/WhiG Krad_1411 216 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 152965850 Common - diacylglycerol kinase catalytic region Krad_1884 53 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 152967472 Common - 4-alpha-glucanotransferase Krad_3529 117 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 152967498 Common - major facilitator superfamily MFS_1 Krad_3555 93 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152966283 Nonpathogen - hypothetical protein Krad_2322 1 None None None 152968252 Common - Alpha/beta hydrolase fold-3 domain protein Krad_4309 99 COG0657 Aes, Esterase/lipase Lipid metabolism 152966423 Common - transcriptional regulator, XRE family Krad_2467 53 COG1476 COG1476, Predicted transcriptional regulators Transcription 152967046 Nonpathogen - hypothetical protein Krad_3102 1 None None None 152964945 Nonpathogen - hypothetical protein Krad_0977 1 None None None 152965041 Common - Phosphopyruvate hydratase Krad_1073 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 152964047 Common - FHA domain containing protein Krad_0076 34 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 152965291 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Krad_1323 215 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 152966352 Nonpathogen - hypothetical protein Krad_2392 1 None None None 152967659 Common - Exonuclease RNase T and DNA polymerase III Krad_3716 88 COG1949 Orn, Oligoribonuclease (3'->5' exoribonuclease) RNA processing and modification 152965510 Common - amidohydrolase Krad_1544 131 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 152964499 Common - hypoxanthine phosphoribosyltransferase Krad_0530 153 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 152967680 Common - diguanylate cyclase Krad_3737 174 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152964070 Common - diguanylate cyclase Krad_0099 165 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152965916 Common - NADP oxidoreductase coenzyme F420-dependent Krad_1950 36 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 152965175 Common - Vitamin K epoxide reductase Krad_1207 17 COG4243 COG4243, Predicted membrane protein Function unknown 152965232 Common - ATP synthase F0, A subunit Krad_1264 190 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 152965281 Common - protein of unknown function DUF523 Krad_1313 52 COG1683 COG1683, Uncharacterized conserved protein Function unknown 152964404 Common - aldo/keto reductase Krad_0434 200 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152968070 Common - amidase, hydantoinase/carbamoylase family Krad_4127 84 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 152966697 Common - luciferase family protein Krad_2745 111 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152966080 Common - NAD-dependent epimerase/dehydratase Krad_2115 45 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152968410 Nonpathogen - hypothetical protein Krad_4471 3 None None None 152966621 Common - Endoribonuclease L-PSP Krad_2669 34 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 152964488 Common - putative amino acid transporter Krad_0519 16 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 152964582 Nonpathogen - Protein of unknown function DUF1713 Krad_0613 1 None None None 152966707 Common - DGPFAETKE family protein Krad_2755 2 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 152967619 Nonpathogen - hypothetical protein Krad_3676 1 None None None 152966361 Nonpathogen - hypothetical protein Krad_2401 1 None None None 152967947 Nonpathogen - hypothetical protein Krad_4004 2 None None None 152967123 Common - oxidoreductase domain protein Krad_3179 83 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152965029 Nonpathogen - hypothetical protein Krad_1061 1 None None None 152964574 Common - diguanylate cyclase Krad_0605 173 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152966114 Nonpathogen - PilT protein-like protein Krad_2150 4 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 152964557 Common - oxidoreductase domain protein Krad_0588 126 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152966750 Nonpathogen - hypothetical protein Krad_2800 1 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 152967558 Common - Endonuclease/exonuclease/phosphatase Krad_3615 97 COG2374 COG2374, Predicted extracellular nuclease General function prediction only 152966749 Common - hypothetical protein Krad_2799 18 COG4671 COG4671, Predicted glycosyl transferase General function prediction only 152964078 Common - 2-methylcitrate dehydratase Krad_0107 72 COG2079 PrpD, Uncharacterized protein involved in propionate catabolism General function prediction only 152965677 Nonpathogen - hypothetical protein Krad_1711 1 None None None 152966397 Common - putative GAF sensor protein Krad_2438 37 COG2203 FhlA, FOG: GAF domain Signal transduction mechanisms 152966040 Common - aldehyde oxidase and xanthine dehydrogenase molybdopterin binding Krad_2075 122 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 152965476 Common - ATP-cone domain protein Krad_1508 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 152967652 Common - SSS sodium solute transporter superfamily Krad_3709 67 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 152966740 Common - transcriptional regulator, TetR family Krad_2790 18 COG1309 AcrR, Transcriptional regulator Transcription 152967877 Common - Helix-turn-helix type 11 domain protein Krad_3934 52 COG2378 COG2378, Predicted transcriptional regulator Transcription 152966483 Common - major facilitator superfamily MFS_1 Krad_2528 17 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 152964644 Common - NusG antitermination factor Krad_0675 215 COG0250 NusG, Transcription antiterminator Transcription 152966557 Common - transcriptional regulator, TetR family Krad_2604 30 COG1309 AcrR, Transcriptional regulator Transcription 152966944 Common - orotidine 5'-phosphate decarboxylase Krad_3000 64 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 152964138 Common - glycosyl transferase family 2 Krad_0167 28 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152966142 Nonpathogen - hypothetical protein Krad_2179 1 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 152967166 Nonpathogen - hypothetical protein Krad_3222 7 None None None 152965371 Common - signal peptidase I Krad_1403 70 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 152965202 Common - protein of unknown function DUF21 Krad_1234 213 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 152967361 Nonpathogen - major facilitator superfamily MFS_1 Krad_3417 1 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152968278 Common - ATPase AAA-2 domain protein Krad_4335 232 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 152967339 Nonpathogen - hypothetical protein Krad_3395 6 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 152968077 Common - hypothetical protein Krad_4134 3 None None None 152967703 Common - beta-Ig-H3/fasciclin Krad_3760 61 COG2335 COG2335, Secreted and surface protein containing fasciclin-like repeats Cell envelope biogenesis, outer membrane 152967273 Nonpathogen - protein of unknown function DUF1023 Krad_3329 2 None None None 152964307 Common - alpha/beta hydrolase fold Krad_0337 134 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152967172 Common - Zeta-phytoene desaturase Krad_3228 88 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 152964562 Common - oxidoreductase domain protein Krad_0593 16 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152964588 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Krad_0619 97 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 152963996 Nonpathogen - hypothetical protein Krad_0024 2 None None None 152966402 Common - hypothetical protein Krad_2443 13 None None None 152967081 Common - AMP-dependent synthetase and ligase Krad_3137 219 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152965022 Common - Aminoacyl-tRNA hydrolase Krad_1054 174 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 152967327 Nonpathogen - type I phosphodiesterase/nucleotide pyrophosphatase Krad_3383 6 COG1950 COG1950, Predicted membrane protein Function unknown 152965903 Common - NADPH-dependent FMN reductase Krad_1937 42 COG0431 COG0431, Predicted flavoprotein General function prediction only 152965834 Common - efflux transporter, RND family, MFP subunit Krad_1868 13 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 152967897 Common - succinate dehydrogenase, flavoprotein subunit Krad_3954 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 152965700 Nonpathogen - hypothetical protein Krad_1734 1 None None None 152964511 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Krad_0542 144 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 152967998 Common - Xylose isomerase domain protein TIM barrel Krad_4055 63 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 152966708 Common - protein of unknown function DUF350 Krad_2756 6 None None None 152964842 Common - phosphate ABC transporter, inner membrane subunit PstC Krad_0874 223 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 152964673 Common - ribosomal protein L18 Krad_0704 215 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 152964233 Common - stress protein Krad_0263 24 COG2310 TerZ, Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 Signal transduction mechanisms 152965709 Nonpathogen - hypothetical protein Krad_1743 1 None None None 152965534 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Krad_1568 183 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152965859 Common - major facilitator superfamily MFS_1 Krad_1893 28 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 152967307 Common - CoA-binding domain protein Krad_3363 134 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 152964454 Nonpathogen - putative anti-sigma regulatory factor, serine/threonine protein kinase Krad_0484 4 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152966133 Common - ABC transporter-related protein Krad_2170 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 152967410 Common - binding-protein-dependent transport systems inner membrane component Krad_3467 128 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152963978 Common - DNA gyrase, B subunit Krad_0006 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 152965621 Common - Lytic transglycosylase catalytic Krad_1655 197 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 152966992 Common - (p)ppGpp synthetase I, SpoT/RelA Krad_3048 207 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 152967546 Common - TrkA-N domain protein Krad_3603 83 COG1226 Kch, Kef-type K+ transport systems, predicted NAD-binding component Inorganic ion transport and metabolism 152968016 Common - transcriptional regulator, LysR family Krad_4073 17 COG0583 LysR, Transcriptional regulator Transcription 152967727 Nonpathogen - hypothetical protein Krad_3784 1 None None None 152967417 Common - Methyltransferase type 12 Krad_3474 10 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 152964446 Nonpathogen - hypothetical protein Krad_0476 6 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 152964507 Common - ATP-dependent metalloprotease FtsH Krad_0538 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 152966643 Common - protein of unknown function DUF1470 Krad_2691 25 COG5516 COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding General function prediction only 152967060 Common - phospholipid/glycerol acyltransferase Krad_3116 89 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 152964113 Common - RNA-binding S4 domain protein Krad_0142 99 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 152964938 Nonpathogen - hypothetical protein Krad_0970 1 None None None 152964353 Common - peptidase S8 and S53 subtilisin kexin sedolisin Krad_0383 94 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 152966505 Nonpathogen - hypothetical protein Krad_2550 1 None None None 152967330 Common - protein of unknown function UPF0054 Krad_3386 69 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 152965973 Common - diguanylate cyclase/phosphodiesterase Krad_2008 176 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152968400 Common - putative phosphodiesterase Krad_4461 7 None None None 152965006 Common - Alanine racemase Krad_1038 126 COG1609 PurR, Transcriptional regulators Transcription 152965892 Nonpathogen - Death-on-curing protein Krad_1926 1 COG3654 Doc, Prophage maintenance system killer protein General function prediction only 152966604 Nonpathogen - DoxX family protein Krad_2652 1 None None None 152964800 Common - Tetracyclin repressor domain protein Krad_0832 23 None None None 152967298 Common - glutaredoxin Krad_3354 11 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 152967174 Common - hypothetical protein Krad_3230 15 None None None 152965640 Nonpathogen - hypothetical protein Krad_1674 1 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 152965351 Common - hypothetical protein Krad_1383 36 COG4430 COG4430, Uncharacterized protein conserved in bacteria Function unknown 152966526 Common - NADP oxidoreductase coenzyme F420-dependent Krad_2571 26 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 152968405 Nonpathogen - transcriptional regulator, MarR family Krad_4466 1 COG1846 MarR, Transcriptional regulators Transcription 152966536 Common - extracellular solute-binding protein family 1 Krad_2582 110 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152964825 Common - phosphate acetyltransferase Krad_0857 153 COG0280 Pta, Phosphotransacetylase Energy production and conversion 152965406 Common - Endonuclease/exonuclease/phosphatase Krad_1438 17 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 152965843 Common - peptidylprolyl isomerase FKBP-type Krad_1877 129 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 152966737 Nonpathogen - Clp domain protein Krad_2787 1 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 152967382 Nonpathogen - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_3439 1 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152965012 Common - Transglycosylase domain protein Krad_1044 28 COG3583 COG3583, Uncharacterized protein conserved in bacteria Function unknown 152965314 Nonpathogen - hypothetical protein Krad_1346 3 None None None 152967826 Common - phosphoesterase PA-phosphatase related Krad_3883 7 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 152965549 Common - two component transcriptional regulator, LuxR family Krad_1583 83 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152968265 Common - Silent information regulator protein Sir2 Krad_4322 148 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 152967548 Common - putative cold-shock DNA-binding domain protein Krad_3605 178 COG1278 CspC, Cold shock proteins Transcription 152964025 Nonpathogen - hypothetical protein Krad_0054 1 None None None 152966376 Nonpathogen - hypothetical protein Krad_2416 1 None None None 152968366 Common - hypothetical protein Krad_4427 27 None None None 152965597 Common - protein of unknown function DUF820 Krad_1631 28 COG4636 Uma2, Uncharacterized protein conserved in cyanobacteria Function unknown 152967228 Common - lipoate-protein ligase B Krad_3284 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 152964947 Common - hypothetical protein Krad_0979 10 None None None 152965618 Nonpathogen - flagellar biosynthesis/type III secretory pathway protein-like protein Krad_1652 2 COG1317 FliH, Flagellar biosynthesis/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 152967971 Common - acetyl-CoA acetyltransferase Krad_4028 167 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 152964940 Common - extracellular solute-binding protein family 1 Krad_0972 92 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152965623 Common - flagellar hook capping protein Krad_1657 35 COG1843 FlgD, Flagellar hook capping protein Cell motility and secretion 152965229 Common - glycosyl transferase family 4 Krad_1261 77 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 152966481 Common - glycoside hydrolase family 1 Krad_2526 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 152965616 Common - flagellar M-ring protein FliF Krad_1650 127 COG1766 FliF, Flagellar biosynthesis/type III secretory pathway lipoprotein Cell motility and secretion / Intracellular trafficking and secretion 152964421 Common - major facilitator superfamily MFS_1 Krad_0451 212 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152966908 Common - tryptophan synthase, alpha subunit Krad_2964 212 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 152966801 Common - Epoxide hydrolase domain protein Krad_2855 38 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152965756 Common - protein of unknown function UPF0061 Krad_1790 110 COG0397 COG0397, Uncharacterized conserved protein Function unknown 152964037 Common - Uncharacterized protein UPF0065 Krad_0066 74 COG3181 COG3181, Uncharacterized protein conserved in bacteria Function unknown 152965757 Common - methionine aminopeptidase, type I Krad_1791 234 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 152966213 Nonpathogen - hypothetical protein Krad_2252 1 None None None 152964738 Common - transcriptional regulator, RpiR family Krad_0770 108 COG1737 RpiR, Transcriptional regulators Transcription 152966208 Nonpathogen - hypothetical protein Krad_2247 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 152968288 Common - diguanylate cyclase Krad_4345 176 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152966021 Common - FAD dependent oxidoreductase Krad_2056 67 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 152966636 Nonpathogen - hypothetical protein Krad_2684 1 None None None 152964477 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Krad_0508 98 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 152965868 Common - hypothetical protein Krad_1902 3 COG3541 COG3541, Predicted nucleotidyltransferase General function prediction only 152967460 Common - Endopeptidase Clp Krad_3517 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 152964395 Common - beta-lactamase domain protein Krad_0425 16 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 152964671 Common - ribosomal protein S8 Krad_0702 244 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 152966131 Nonpathogen - Zinc finger protein ZFPM1 Krad_2168 1 None None None 152967536 Common - Xylose isomerase domain protein TIM barrel Krad_3593 23 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 152965181 Common - Anti-sigma factor RshA Krad_1213 13 None None None 152967346 Nonpathogen - GCN5-related N-acetyltransferase Krad_3402 1 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 152967021 Common - high-affinity nickel-transporter Krad_3077 40 COG3376 HoxN, High-affinity nickel permease Inorganic ion transport and metabolism 152967169 Common - Zeta-phytoene desaturase Krad_3225 86 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 152966503 Common - Endo-1,4-beta-xylanase Krad_2548 32 COG3693 XynA, Beta-1,4-xylanase Carbohydrate transport and metabolism 152968096 Common - Acetamidase/Formamidase Krad_4153 64 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 152964225 Common - HAD-superfamily hydrolase, subfamily IIB Krad_0255 81 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 152967337 Common - peptidase S9 prolyl oligopeptidase active site domain protein Krad_3393 142 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 152965909 Nonpathogen - hypothetical protein Krad_1943 1 None None None 152966042 Common - Allantoinase Krad_2077 196 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 152965340 Common - pantetheine-phosphate adenylyltransferase Krad_1372 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 152964714 Common - major facilitator superfamily MFS_1 Krad_0745 12 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152964868 Common - 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Krad_0900 27 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 152964809 Common - aldehyde dehydrogenase Krad_0841 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 152965745 Nonpathogen - hypothetical protein Krad_1779 1 COG1813 COG1813, Predicted transcription factor, homolog of eukaryotic MBF1 Transcription 152967113 Common - translation initiation factor IF-3 Krad_3169 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 152965262 Common - 1,4-alpha-glucan branching enzyme Krad_1294 145 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 152965540 Common - CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase Krad_1574 32 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 152966030 Common - transcriptional regulator, PucR family Krad_2065 13 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 152966054 Common - Alcohol dehydrogenase zinc-binding domain protein Krad_2089 211 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 152964084 Common - NUDIX hydrolase Krad_0113 24 COG4119 COG4119, Predicted NTP pyrophosphohydrolase DNA replication, recombination, and repair / General function prediction only 152968138 Common - Pyridoxal 4-dehydrogenase Krad_4195 37 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152965216 Common - protein of unknown function SprT Krad_1248 5 COG3091 SprT, Uncharacterized protein conserved in bacteria Function unknown 152964328 Nonpathogen - hypothetical protein Krad_0358 1 None None None 152965065 Common - magnesium chelatase, ChlI subunit Krad_1097 50 COG1239 ChlI, Mg-chelatase subunit ChlI Coenzyme metabolism 152964541 Common - SAF domain protein Krad_0572 37 COG4091 COG4091, Predicted homoserine dehydrogenase Amino acid transport and metabolism 152966752 Common - two component transcriptional regulator, winged helix family Krad_2802 211 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152967782 Common - putative transcriptional regulator, RpiR family Krad_3839 18 COG1737 RpiR, Transcriptional regulators Transcription 152966965 Nonpathogen - hypothetical protein Krad_3021 2 COG4726 PilX, Tfp pilus assembly protein PilX Cell motility and secretion / Intracellular trafficking and secretion 152968372 Common - major facilitator superfamily MFS_1 Krad_4433 19 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152967854 Common - maf protein Krad_3911 135 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 152968291 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Krad_4348 6 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152964402 Common - metallophosphoesterase Krad_0432 60 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 152967278 Common - Phosphoglycerate mutase Krad_3334 137 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 152964858 Common - glycosyl transferase group 1 Krad_0890 116 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152965269 Common - monoxygenase Krad_1301 63 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152964216 Common - diguanylate cyclase/phosphodiesterase with GAF sensor Krad_0246 163 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152966410 Nonpathogen - hypothetical protein Krad_2451 1 None None None 152967098 Common - DNA-3-methyladenine glycosylase Krad_3154 84 COG2094 Mpg, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 152965958 Common - two component transcriptional regulator, LuxR family Krad_1992 162 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152964372 Common - peptide deformylase Krad_0402 211 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 152964144 Common - DEAD/DEAH box helicase domain protein Krad_0173 123 COG4581 COG4581, Superfamily II RNA helicase DNA replication, recombination, and repair 152965648 Common - 3-Oxoacyl-(acyl-carrier-protein (ACP)) synthase III domain protein Krad_1682 209 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 152968302 Common - Alcohol dehydrogenase GroES domain protein Krad_4359 199 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 152965415 Common - drug resistance transporter, EmrB/QacA subfamily Krad_1447 205 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152964065 Common - GCN5-related N-acetyltransferase Krad_0094 23 COG0456 RimI, Acetyltransferases General function prediction only 152965253 Common - phenylalanine/histidine ammonia-lyase Krad_1285 106 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 152968329 Common - DEAD/DEAH box helicase domain protein Krad_4387 29 COG1205 COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster General function prediction only 152964208 Common - ABC transporter-related protein Krad_0238 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 152967598 Common - diacylglycerol kinase catalytic region Krad_3655 19 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 152966016 Nonpathogen - hypothetical protein Krad_2051 1 None None None 152966488 Common - alpha-L-rhamnosidase Krad_2533 23 None None None 152966911 Nonpathogen - hypothetical protein Krad_2967 1 None None None 152968049 Common - FAD-binding 9 siderophore-interacting domain protein Krad_4106 63 COG2375 ViuB, Siderophore-interacting protein Inorganic ion transport and metabolism 152964608 Common - diguanylate cyclase/phosphodiesterase Krad_0639 164 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152967249 Common - hypothetical protein Krad_3305 24 None None None 152968435 Common - hypothetical protein Krad_4496 6 None None None 152964049 Common - Arabinan endo-1,5-alpha-L-arabinosidase Krad_0078 19 COG3507 XynB, Beta-xylosidase Carbohydrate transport and metabolism 152967389 Common - luciferase family protein Krad_3446 51 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152965525 Common - nucleic acid binding OB-fold tRNA/helicase-type Krad_1559 13 None None None 152966738 Nonpathogen - hypothetical protein Krad_2788 1 None None None 152968045 Nonpathogen - hypothetical protein Krad_4102 1 None None None 152967254 Common - protein of unknown function DUF475 Krad_3310 42 COG2899 COG2899, Uncharacterized protein conserved in bacteria Function unknown 152964503 Common - protein of unknown function DUF1445 Krad_0534 41 COG4336 COG4336, Uncharacterized conserved protein Function unknown 152967326 Nonpathogen - hypothetical protein Krad_3382 6 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 152966409 Common - peptidase S26B, signal peptidase Krad_2450 4 None None None 152965768 Common - Lytic transglycosylase catalytic Krad_1802 14 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 152964445 Common - penicillin-binding protein transpeptidase Krad_0475 88 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 152964057 Common - NmrA family protein Krad_0086 67 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152965386 Common - ribosome recycling factor Krad_1418 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 152966396 Common - hypothetical protein Krad_2436 13 None None None 152964897 Common - hypothetical protein Krad_0929 16 COG4529 COG4529, Uncharacterized protein conserved in bacteria Function unknown 152967759 Common - integral membrane protein Krad_3816 9 None None None 152964654 Common - translation elongation factor Tu Krad_0685 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 152965660 Nonpathogen - hypothetical protein Krad_1694 1 None None None 152966770 Common - Endoribonuclease L-PSP Krad_2820 52 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 152965118 Common - O-methyltransferase family 3 Krad_1150 45 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 152964195 Common - GAF domain protein Krad_0224 8 None None None 152966319 Common - hypothetical protein Krad_2359 3 None None None 152964314 Common - methyl-accepting chemotaxis sensory transducer Krad_0344 74 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152966312 Common - MOSC domain containing protein Krad_2352 78 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 152967086 Common - glycosyl transferase group 1 Krad_3142 133 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152965057 Nonpathogen - putative signal transduction histidine kinase Krad_1089 1 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152966766 Common - transcriptional regulator, PadR-like family Krad_2816 60 COG1695 COG1695, Predicted transcriptional regulators Transcription 152964428 Common - cyclic nucleotide-binding protein Krad_0458 30 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152967353 Common - luciferase family protein Krad_3409 18 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152965235 Common - ATP synthase F1, delta subunit Krad_1267 123 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 152965567 Common - molybdopterin oxidoreductase Fe4S4 region Krad_1601 147 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 152966036 Common - Urate oxidase Krad_2071 14 COG3648 COG3648, Uricase (urate oxidase) Secondary metabolites biosynthesis, transport, and catabolism 152964432 Common - aspartate-semialdehyde dehydrogenase Krad_0462 236 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 152965033 Nonpathogen - hypothetical protein Krad_1065 1 None None None 152968211 Common - luciferase family protein Krad_4268 42 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152967817 Common - hypothetical protein Krad_3874 4 COG5305 COG5305, Predicted membrane protein Function unknown 152964908 Common - binding-protein-dependent transport systems inner membrane component Krad_0940 203 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 152968352 Common - Amidase Krad_4413 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 152965273 Common - binding-protein-dependent transport systems inner membrane component Krad_1305 132 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 152967960 Common - binding-protein-dependent transport systems inner membrane component Krad_4017 150 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152966371 Nonpathogen - hypothetical protein Krad_2411 1 None None None 152965086 Common - PfkB domain protein Krad_1118 98 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 152967467 Common - hypothetical protein Krad_3524 16 COG3917 NahD, 2-hydroxychromene-2-carboxylate isomerase Secondary metabolites biosynthesis, transport, and catabolism 152967796 Common - cyclase family protein Krad_3853 50 COG1878 COG1878, Predicted metal-dependent hydrolase General function prediction only 152965930 Nonpathogen - protein of unknown function DUF214 Krad_1964 3 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 152968428 Common - major facilitator superfamily MFS_1 Krad_4489 175 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 152965492 Common - 6-phosphogluconate dehydrogenase, decarboxylating Krad_1524 168 COG0362 Gnd, 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 152968199 Common - drug resistance transporter, EmrB/QacA subfamily Krad_4256 54 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 152964101 Common - protein of unknown function DUF6 transmembrane Krad_0130 33 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 152965506 Common - phosphoenolpyruvate-protein phosphotransferase Krad_1540 201 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 152966842 Common - hypothetical protein Krad_2898 7 None None None 152966266 Common - drug resistance transporter, EmrB/QacA subfamily Krad_2305 147 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152964482 Common - O-acetylhomoserine/O-acetylserine sulfhydrylase Krad_0513 206 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 152965664 Nonpathogen - hypothetical protein Krad_1698 1 None None None 152964577 Common - hypothetical protein Krad_0608 9 None None None 152967012 Nonpathogen - hypothetical protein Krad_3068 1 None None None 152968444 Common - hypothetical protein Krad_4505 12 None None None 152968231 Common - Pyruvate dehydrogenase (acetyl-transferring) Krad_4288 152 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 152965034 Common - hypothetical protein Krad_1066 8 None None None 152966563 Nonpathogen - hypothetical protein Krad_2610 1 None None None 152967157 Common - DNA-directed DNA polymerase Krad_3213 186 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 152967862 Common - hypothetical protein Krad_3919 21 None None None 152965638 Common - response regulator receiver protein Krad_1672 219 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152966242 Nonpathogen - hypothetical protein Krad_2281 1 None None None 152968315 Nonpathogen - hypothetical protein Krad_4372 1 None None None 152964293 Common - response regulator receiver protein Krad_0323 217 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152966619 Common - Alpha/beta hydrolase fold-3 domain protein Krad_2667 70 COG0657 Aes, Esterase/lipase Lipid metabolism 152964338 Common - Serine-type D-Ala-D-Ala carboxypeptidase Krad_0368 99 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 152967882 Common - major facilitator superfamily MFS_1 Krad_3939 78 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152964359 Common - oxidoreductase domain protein Krad_0389 56 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152965772 Common - two component transcriptional regulator, winged helix family Krad_1806 217 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152968333 Common - helicase domain protein Krad_4392 125 COG1201 Lhr, Lhr-like helicases General function prediction only 152965689 Common - phage Terminase Krad_1723 4 None None None 152967551 Common - Asparaginase/glutaminase Krad_3608 79 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 152967486 Nonpathogen - hypothetical protein Krad_3543 1 None None None 152968347 Common - UvrD/REP helicase Krad_4408 190 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 152966236 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_2275 4 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152966355 Common - transposase IS3/IS911 family protein Krad_2395 59 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 152965019 Common - UDP-N-acetylglucosamine pyrophosphorylase Krad_1051 232 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 152965714 Nonpathogen - hypothetical protein Krad_1748 1 None None None 152966138 Common - hypothetical protein Krad_2175 72 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152964300 Common - acyltransferase 3 Krad_0330 6 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 152964621 Common - DNA primase small subunit Krad_0652 66 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 152966076 Nonpathogen - hypothetical protein Krad_2111 1 None None None 152967433 Common - Nucleoside-diphosphate kinase Krad_3490 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 152966275 Common - hypothetical protein Krad_2314 15 None None None 152966246 Nonpathogen - hypothetical protein Krad_2285 1 None None None 152966728 Common - major facilitator superfamily MFS_1 Krad_2778 202 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152968080 Common - ABC transporter-related protein Krad_4137 247 COG4586 COG4586, ABC-type uncharacterized transport system, ATPase component General function prediction only 152965956 Nonpathogen - hypothetical protein Krad_1990 1 None None None 152965821 Common - putative RecB family exonuclease Krad_1855 16 COG2887 COG2887, RecB family exonuclease DNA replication, recombination, and repair 152968171 Common - Hemerythrin HHE cation binding domain protein Krad_4228 17 None None None 152967372 Common - hypothetical protein Krad_3429 13 None None None 152965682 Nonpathogen - hypothetical protein Krad_1716 1 None None None 152964331 Nonpathogen - hypothetical protein Krad_0361 1 None None None 152964279 Nonpathogen - Molybdopterin-guanine dinucleotide biosynthesis protein A-like protein Krad_0309 1 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 152968359 Common - binding-protein-dependent transport systems inner membrane component Krad_4420 172 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 152966626 Common - hypothetical protein Krad_2674 9 None None None 152966521 Nonpathogen - hypothetical protein Krad_2566 1 None None None 152965165 Common - integral membrane sensor signal transduction histidine kinase Krad_1197 86 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152966116 Common - putative transcriptional regulator, MerR family Krad_2152 114 COG0789 SoxR, Predicted transcriptional regulators Transcription 152964777 Common - protein of unknown function DUF1469 Krad_0809 4 None None None 152967982 Common - hypothetical protein Krad_4039 13 None None None 152968191 Common - transcriptional regulator, MarR family Krad_4248 15 COG1846 MarR, Transcriptional regulators Transcription 152965636 Common - multi-sensor signal transduction histidine kinase Krad_1670 216 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152965121 Common - peptidase S1 and S6 chymotrypsin/Hap Krad_1153 220 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 152963983 Common - protein tyrosine phosphatase Krad_0011 32 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 152967915 Common - galactose-1-phosphate uridylyltransferase Krad_3972 76 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 152968122 Common - Ankyrin Krad_4179 68 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 152967008 Common - CDP-alcohol phosphatidyltransferase Krad_3064 50 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 152967891 Common - ABC transporter-related protein Krad_3948 249 COG3845 COG3845, ABC-type uncharacterized transport systems, ATPase components General function prediction only 152966858 Common - protein of unknown function DUF59 Krad_2914 138 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 152965729 Nonpathogen - hypothetical protein Krad_1763 1 None None None 152967673 Common - extracellular solute-binding protein family 1 Krad_3730 67 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152967766 Common - Cellulose 1,4-beta-cellobiosidase Krad_3823 17 None None None 152966190 Nonpathogen - hypothetical protein Krad_2229 1 None None None 152964749 Common - heavy metal translocating P-type ATPase Krad_0781 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 152966335 Nonpathogen - hypothetical protein Krad_2375 2 None None None 152966779 Nonpathogen - hypothetical protein Krad_2831 1 None None None 152964747 Common - short-chain dehydrogenase/reductase SDR Krad_0779 221 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152965250 Common - Thioredoxin domain Krad_1282 43 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 152967185 Common - AMP-dependent synthetase and ligase Krad_3241 215 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 152964721 Common - hypothetical protein Krad_0752 8 COG3346 COG3346, Uncharacterized conserved protein Function unknown 152967945 Nonpathogen - hypothetical protein Krad_4002 1 None None None 152964833 Common - Catalase Krad_0865 125 COG0753 KatE, Catalase Inorganic ion transport and metabolism 152964784 Common - endo-1,4-beta-xylanase Krad_0816 7 None None None 152965347 Common - binding-protein-dependent transport systems inner membrane component Krad_1379 162 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152966955 Nonpathogen - hypothetical protein Krad_3011 1 None None None 152964173 Common - PfkB domain protein Krad_0202 57 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 152964322 Nonpathogen - hypothetical protein Krad_0352 1 None None None 152967926 Common - formyltetrahydrofolate deformylase Krad_3983 205 COG0788 PurU, Formyltetrahydrofolate hydrolase Nucleotide transport and metabolism 152965848 Common - sec-independent translocation protein mttA/Hcf106 Krad_1882 12 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 152967313 Common - glycyl-tRNA synthetase Krad_3369 86 COG0423 GRS1, Glycyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 152966575 Nonpathogen - hypothetical protein Krad_2623 1 None None None 152968003 Common - transcriptional regulator, GntR family Krad_4060 121 COG2188 PhnF, Transcriptional regulators Transcription 152964790 Nonpathogen - hypothetical protein Krad_0822 1 None None None 152967057 Common - ABC transporter-related protein Krad_3113 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 152967837 Common - gluconate transporter Krad_3894 80 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 152965608 Common - cytochrome bd ubiquinol oxidase subunit I Krad_1642 161 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 152968382 Nonpathogen - putative sugar transferase Krad_4443 6 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 152967967 Common - short-chain dehydrogenase/reductase SDR Krad_4024 177 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152966093 Common - Mannitol dehydrogenase domain Krad_2129 82 COG0246 MtlD, Mannitol-1-phosphate/altronate dehydrogenases Carbohydrate transport and metabolism 152964272 Common - binding-protein-dependent transport systems inner membrane component Krad_0302 147 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152964238 Common - drug resistance transporter, EmrB/QacA subfamily Krad_0268 194 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152964355 Common - extracellular solute-binding protein family 1 Krad_0385 121 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152966456 Common - short-chain dehydrogenase/reductase SDR Krad_2500 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152967429 Common - putative oxygenase Krad_3486 69 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152968087 Common - putative transcriptional regulator, GntR family Krad_4144 179 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 152964167 Common - TRAP dicarboxylate transporter, DctM subunit Krad_0196 121 COG1593 DctQ, TRAP-type C4-dicarboxylate transport system, large permease component Carbohydrate transport and metabolism 152966345 Nonpathogen - hypothetical protein Krad_2385 1 None None None 152968169 Common - ribose 5-phosphate isomerase Krad_4226 120 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 152966896 Nonpathogen - GCN5-related N-acetyltransferase Krad_2952 1 COG0456 RimI, Acetyltransferases General function prediction only 152964690 Common - ribosomal protein S9 Krad_0721 216 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 152967787 Common - hypothetical protein Krad_3844 9 COG3824 COG3824, Uncharacterized protein conserved in bacteria Function unknown 152964646 Common - ribosomal protein L1 Krad_0677 245 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 152964369 Nonpathogen - hypothetical protein Krad_0399 1 None None None 152965812 Common - putative CheW protein Krad_1846 141 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 152964556 Common - Glucuronate isomerase Krad_0587 60 COG1904 UxaC, Glucuronate isomerase Carbohydrate transport and metabolism 152967422 Common - hypothetical protein Krad_3479 8 None None None 152964317 Common - putative PAS/PAC sensor protein Krad_0347 124 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152968343 Nonpathogen - protein of unknown function DUF214 Krad_4404 4 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 152965453 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Krad_1485 204 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 152968178 Nonpathogen - cobalt transport protein Krad_4235 2 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 152966426 Common - Alcohol dehydrogenase GroES domain protein Krad_2470 209 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 152967079 Common - hypothetical protein Krad_3135 6 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 152965954 Nonpathogen - hypothetical protein Krad_1988 1 None None None 152966460 Nonpathogen - hypothetical protein Krad_2505 1 None None None 152965726 Common - RNA polymerase, sigma 28 subunit, FliA/WhiG family Krad_1760 44 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 152964252 Common - Aldose 1-epimerase Krad_0282 90 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 152966436 Nonpathogen - hypothetical protein Krad_2480 1 None None None 152964764 Common - isochorismatase hydrolase Krad_0796 19 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 152965895 Common - hypothetical protein Krad_1929 3 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 152964147 Common - FAD dependent oxidoreductase Krad_0176 32 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 152964928 Common - hypothetical protein Krad_0960 9 None None None 152965106 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Krad_1138 132 COG1146 COG1146, Ferredoxin Energy production and conversion 152964345 Common - transcriptional regulator, TetR family Krad_0375 86 COG1309 AcrR, Transcriptional regulator Transcription 152964255 Common - ribosomal protein S14 Krad_0285 195 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 152967980 Nonpathogen - diguanylate cyclase Krad_4037 2 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152965082 Common - binding-protein-dependent transport systems inner membrane component Krad_1114 171 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152966656 Common - major facilitator superfamily MFS_1 Krad_2704 37 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 152967623 Common - polysaccharide biosynthesis protein Krad_3680 77 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 152966316 Common - major facilitator superfamily MFS_1 Krad_2356 64 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152964467 Common - NADP oxidoreductase coenzyme F420-dependent Krad_0498 41 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 152966019 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Krad_2054 149 COG0388 COG0388, Predicted amidohydrolase General function prediction only 152968337 Common - Appr-1-p processing domain protein Krad_4398 28 COG2110 COG2110, Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 General function prediction only 152967445 Common - acetyl-CoA acetyltransferase Krad_3502 166 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 152964068 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Krad_0097 8 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152965116 Common - hypothetical protein Krad_1148 16 None None None 152966301 Nonpathogen - hypothetical protein Krad_2341 1 None None None 152966680 Common - alpha/beta hydrolase fold Krad_2728 57 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152965920 Common - hypothetical protein Krad_1954 23 COG5207 UBP14, Isopeptidase T Posttranslational modification, protein turnover, chaperones 152964544 Common - pantoate--beta-alanine ligase Krad_0575 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 152966383 Common - hypothetical protein Krad_2423 7 None None None 152965818 Nonpathogen - hypothetical protein Krad_1852 1 None None None 152966796 Common - Integrase catalytic region Krad_2849 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 152967243 Common - ROK family protein Krad_3299 4 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 152967812 Common - putative ammonia monooxygenase Krad_3869 5 COG3180 AbrB, Putative ammonia monooxygenase General function prediction only 152964606 Common - AMP-dependent synthetase and ligase Krad_0637 52 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152967686 Nonpathogen - anti-sigma-factor antagonist Krad_3743 1 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 152964387 Common - protein of unknown function DUF1469 Krad_0417 4 None None None 152966825 Common - phytase Krad_2879 18 COG4247 Phy, 3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase) Lipid metabolism 152964335 Common - hypothetical protein Krad_0365 6 None None None 152968136 Common - Mandelate racemase/muconate lactonizing protein Krad_4193 107 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 152968350 Common - Appr-1-p processing domain protein Krad_4411 7 COG2110 COG2110, Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 General function prediction only 152964793 Common - cyclase/dehydrase Krad_0825 31 COG5637 COG5637, Predicted integral membrane protein Function unknown 152965429 Common - transcriptional regulator, DeoR family Krad_1461 59 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 152965650 Nonpathogen - protein of unknown function DUF58 Krad_1684 1 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 152965442 Common - Alcohol dehydrogenase GroES domain protein Krad_1474 206 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 152964303 Common - response regulator receiver protein Krad_0333 177 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 152968057 Common - phospholipase D/Transphosphatidylase Krad_4114 150 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 152968157 Common - hypothetical protein Krad_4214 7 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 152967037 Common - putative transcriptional regulator, MerR family Krad_3093 24 COG0789 SoxR, Predicted transcriptional regulators Transcription 152964180 Common - NAD-dependent epimerase/dehydratase Krad_0209 42 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152965205 Nonpathogen - hypothetical protein Krad_1237 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 152965516 Common - type I phosphodiesterase/nucleotide pyrophosphatase Krad_1550 22 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 152965097 Common - hypothetical protein Krad_1129 15 None None None 152966772 Common - transcriptional regulator, LysR family Krad_2822 145 COG0583 LysR, Transcriptional regulator Transcription 152965536 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Krad_1570 9 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152966882 Common - hypothetical protein Krad_2938 13 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152966645 Common - Xylose isomerase domain protein TIM barrel Krad_2693 6 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 152966928 Common - methionyl-tRNA formyltransferase Krad_2984 218 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 152967711 Common - isochorismatase hydrolase Krad_3768 112 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 152966864 Common - ABC-2 type transporter Krad_2920 13 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 152967363 Common - putative lipoprotein Krad_3419 30 None None None 152964961 Common - exodeoxyribonuclease V, beta subunit Krad_0993 168 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 152965438 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Krad_1470 5 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 152964152 Common - putative transcriptional regulator, AsnC family Krad_0181 149 COG1522 Lrp, Transcriptional regulators Transcription 152966589 Nonpathogen - Alpha/beta hydrolase fold-3 domain protein Krad_2637 1 COG0657 Aes, Esterase/lipase Lipid metabolism 152967028 Nonpathogen - hypothetical protein Krad_3084 6 None None None 152965604 Common - ethanolamine transproter Krad_1638 151 COG0833 LysP, Amino acid transporters Amino acid transport and metabolism 152966912 Nonpathogen - hypothetical protein Krad_2968 1 None None None 152966853 Common - hypothetical protein Krad_2909 11 None None None 152966775 Nonpathogen - hypothetical protein Krad_2827 1 None None None 152964018 Common - DNA binding domain, excisionase family Krad_0047 30 COG2452 COG2452, Predicted site-specific integrase-resolvase DNA replication, recombination, and repair 152966581 Nonpathogen - hypothetical protein Krad_2629 1 None None None 152967100 Common - arginine repressor, ArgR Krad_3156 80 COG1438 ArgR, Arginine repressor Transcription 152965317 Common - ABC transporter-related protein Krad_1349 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 152968149 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Krad_4206 75 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 152968226 Nonpathogen - hypothetical protein Krad_4283 1 None None None 152964873 Common - Allophanate hydrolase Krad_0905 210 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 152966813 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_2867 35 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152964500 Nonpathogen - protein of unknown function DUF820 Krad_0531 1 None None None 152964471 Common - arsenical-resistance protein Krad_0502 130 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 152967234 Common - RDD domain containing protein Krad_3290 16 COG1714 COG1714, Predicted membrane protein/domain Function unknown 152966229 Nonpathogen - hypothetical protein Krad_2268 1 None None None 152967890 Common - inner-membrane translocator Krad_3947 65 COG4603 COG4603, ABC-type uncharacterized transport system, permease component General function prediction only 152964229 Common - hypothetical protein Krad_0259 12 None None None 152967733 Common - cell divisionFtsK/SpoIIIE Krad_3790 50 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 152966378 Nonpathogen - hypothetical protein Krad_2418 1 None None None 152968227 Nonpathogen - hypothetical protein Krad_4284 1 None None None 152966034 Common - hypothetical protein Krad_2069 16 COG3195 COG3195, Uncharacterized protein conserved in bacteria Function unknown 152966441 Common - class II aldolase/adducin family protein Krad_2485 103 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 152965186 Common - protein of unknown function DUF664 Krad_1218 13 COG2318 DinB, Uncharacterized protein conserved in bacteria Function unknown 152967470 Nonpathogen - hypothetical protein Krad_3527 4 None None None 152965562 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_1596 135 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152967217 Common - putative GAF sensor protein Krad_3273 55 COG3284 AcoR, Transcriptional activator of acetoin/glycerol metabolism Secondary metabolites biosynthesis, transport, and catabolism / Transcription 152964695 Common - carbohydrate kinase, YjeF related protein Krad_0726 86 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 152967121 Common - hypothetical protein Krad_3177 3 None None None 152965578 Common - diguanylate cyclase/phosphodiesterase Krad_1612 176 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152966281 Nonpathogen - hypothetical protein Krad_2320 1 None None None 152968357 Nonpathogen - hypothetical protein Krad_4418 1 None None None 152967821 Common - LGFP repeat protein Krad_3878 15 COG5479 COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis Cell envelope biogenesis, outer membrane 152965484 Common - ABC transporter-related protein Krad_1516 245 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 152966188 Common - malate synthase A Krad_2227 58 COG2225 AceB, Malate synthase Energy production and conversion 152968115 Common - tRNA/rRNA methyltransferase (SpoU) Krad_4172 17 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 152966705 Nonpathogen - hypothetical protein Krad_2753 1 None None None 152967869 Nonpathogen - hypothetical protein Krad_3926 1 COG5373 COG5373, Predicted membrane protein Function unknown 152967937 Nonpathogen - hypothetical protein Krad_3994 1 None None None 152966292 Nonpathogen - hypothetical protein Krad_2332 1 None None None 152967634 Common - FAD dependent oxidoreductase Krad_3691 54 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 152964591 Common - metallophosphoesterase Krad_0622 8 None None None 152965268 Common - transcriptional regulator, TetR family Krad_1300 11 COG1309 AcrR, Transcriptional regulator Transcription 152965336 Common - DEAD/DEAH box helicase domain protein Krad_1368 210 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 152966069 Common - band 7 protein Krad_2104 38 COG2268 COG2268, Uncharacterized protein conserved in bacteria Function unknown 152964188 Common - hypothetical protein Krad_0217 41 COG0390 COG0390, ABC-type uncharacterized transport system, permease component General function prediction only 152965310 Common - hypothetical protein Krad_1342 39 COG4338 COG4338, Uncharacterized protein conserved in bacteria Function unknown 152964665 Common - ribosomal protein L29 Krad_0696 131 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 152964218 Common - diacylglycerol kinase catalytic region Krad_0248 113 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 152964484 Common - sodium:dicarboxylate symporter Krad_0515 154 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 152967507 Common - binding-protein-dependent transport systems inner membrane component Krad_3564 145 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152965770 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Krad_1804 10 COG3871 COG3871, Uncharacterized stress protein (general stress protein 26) General function prediction only 152965873 Common - UBA/THIF-type NAD/FAD binding protein Krad_1907 204 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 152966541 Common - diguanylate cyclase/phosphodiesterase Krad_2587 177 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152965910 Common - Na+/H+ antiporter Krad_1944 90 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 152967355 Common - putative oxygen-independent coproporphyrinogen III oxidase Krad_3411 213 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 152966332 Nonpathogen - hypothetical protein Krad_2372 1 None None None 152964448 Nonpathogen - hypothetical protein Krad_0478 1 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 152965847 Nonpathogen - hypothetical protein Krad_1881 3 None None None 152966673 Nonpathogen - hypothetical protein Krad_2721 1 None None None 152967780 Common - lipolytic protein G-D-S-L family Krad_3837 11 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 152967426 Common - SUF system FeS assembly protein, NifU family Krad_3483 72 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 152964844 Common - NUDIX hydrolase Krad_0876 15 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 152968014 Common - diguanylate cyclase Krad_4071 149 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152965270 Common - NMT1/THI5 like domain protein Krad_1302 61 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 152967500 Common - quinolinate synthetase complex, A subunit Krad_3557 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 152966667 Common - Alcohol dehydrogenase GroES domain protein Krad_2715 169 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 152967491 Common - RNA-binding S4 domain protein Krad_3548 26 COG2501 COG2501, Uncharacterized conserved protein Function unknown 152966559 Nonpathogen - hypothetical protein Krad_2606 1 None None None 152966412 Common - PAS fold-3 domain protein Krad_2453 48 None None None 152967180 Common - hypothetical protein Krad_3236 2 None None None 152966169 Common - NmrA family protein Krad_2208 46 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152965577 Common - Fibronectin type III domain protein Krad_1611 29 COG3889 COG3889, Predicted solute binding protein General function prediction only 152967069 Nonpathogen - integral membrane protein Krad_3125 6 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 152968424 Common - putative PAS/PAC sensor protein Krad_4485 65 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152966784 Nonpathogen - hypothetical protein Krad_2836 1 None None None 152964968 Common - 3-dehydroquinate dehydratase, type II Krad_1000 169 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 152967654 Common - protein tyrosine phosphatase Krad_3711 136 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 152967406 Common - Acyl-CoA dehydrogenase type 2 domain Krad_3463 101 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 152964615 Common - 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Krad_0646 74 COG1165 MenD, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Coenzyme metabolism 152965949 Common - diguanylate phosphodiesterase Krad_1983 168 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152964992 Common - major facilitator superfamily MFS_1 Krad_1024 134 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152966144 Common - short-chain dehydrogenase/reductase SDR Krad_2181 217 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152965836 Common - protein of unknown function DUF214 Krad_1870 161 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 152965373 Common - Ribonuclease H Krad_1405 214 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 152967101 Common - ornithine carbamoyltransferase Krad_3157 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 152967324 Common - aldo/keto reductase Krad_3380 185 COG4989 COG4989, Predicted oxidoreductase General function prediction only 152968092 Common - periplasmic binding protein/LacI transcriptional regulator Krad_4149 126 COG1609 PurR, Transcriptional regulators Transcription 152964753 Common - MOSC domain containing protein Krad_0785 36 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 152967305 Common - DNA primase Krad_3361 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 152963998 Common - protein of unknown function DUF881 Krad_0026 25 COG3879 COG3879, Uncharacterized protein conserved in bacteria Function unknown 152967218 Common - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Krad_3274 19 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 152966578 Common - monooxygenase FAD-binding Krad_2626 37 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 152966089 Common - Inosine/uridine-preferring nucleoside hydrolase Krad_2125 79 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 152966660 Common - 2,5-didehydrogluconate reductase Krad_2708 182 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 152967453 Common - transcriptional regulator, PadR-like family Krad_3510 13 COG1695 COG1695, Predicted transcriptional regulators Transcription 152965707 Nonpathogen - hypothetical protein Krad_1741 1 None None None 152964263 Common - lipoprotein Krad_0293 30 COG4222 COG4222, Uncharacterized protein conserved in bacteria Function unknown 152966465 Nonpathogen - hypothetical protein Krad_2510 1 None None None 152967870 Common - PHP domain protein Krad_3927 11 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 152964785 Common - membrane protein-like protein Krad_0817 5 COG4129 COG4129, Predicted membrane protein Function unknown 152965204 Common - hypothetical protein Krad_1236 8 None None None 152967511 Common - periplasmic binding protein/LacI transcriptional regulator Krad_3568 127 COG1609 PurR, Transcriptional regulators Transcription 152965826 Common - Rhodanese domain protein Krad_1860 139 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152964851 Common - ferric uptake regulator, Fur family Krad_0883 81 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 152964231 Common - aldo/keto reductase Krad_0261 179 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152965558 Common - secreted protein Krad_1592 16 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 152967062 Common - Prephenate dehydrogenase Krad_3118 145 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 152964758 Common - hypothetical protein Krad_0790 4 COG4994 COG4994, Uncharacterized protein conserved in bacteria Function unknown 152964890 Common - regulatory protein LacI Krad_0922 122 COG1609 PurR, Transcriptional regulators Transcription 152966419 Nonpathogen - hypothetical protein Krad_2463 1 None None None 152967671 Common - periplasmic binding protein/LacI transcriptional regulator Krad_3728 90 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152966308 Common - hypothetical protein Krad_2348 13 None None None 152965478 Common - hypothetical protein Krad_1510 3 None None None 152965734 Nonpathogen - Exonuclease RNase T and DNA polymerase III Krad_1768 1 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 152964011 Common - LGFP repeat protein Krad_0039 13 COG5479 COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis Cell envelope biogenesis, outer membrane 152966099 Common - inositol monophosphatase Krad_2135 140 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 152967393 Common - nicotinate (nicotinamide) nucleotide adenylyltransferase Krad_3450 179 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 152968158 Nonpathogen - hypothetical protein Krad_4215 1 None None None 152967139 Common - protein of unknown function DUF152 Krad_3195 131 COG1496 COG1496, Uncharacterized conserved protein Function unknown 152967641 Common - Stage II sporulation E family protein Krad_3698 80 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152967951 Common - Sua5/YciO/YrdC/YwlC family protein Krad_4008 163 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 152964164 Common - hypothetical protein Krad_0193 9 None None None 152964081 Common - L-asparaginase II Krad_0110 46 COG4448 AnsA, L-asparaginase II Amino acid transport and metabolism 152965585 Common - protein of unknown function DUF180 Krad_1619 34 COG1699 COG1699, Uncharacterized protein conserved in bacteria Function unknown 152964656 Common - ribosomal protein S10 Krad_0687 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 152966995 Common - protein-export membrane protein SecD Krad_3051 201 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 152966932 Common - primosomal protein N' (replication factor Y) Krad_2988 126 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 152968052 Common - Rieske (2Fe-2S) domain protein Krad_4109 66 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 152966254 Common - major facilitator superfamily MFS_1 Krad_2293 150 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152965852 Common - Methyltransferase type 11 Krad_1886 71 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152967888 Common - cytidine deaminase Krad_3945 123 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 152964072 Nonpathogen - hypothetical protein Krad_0101 1 None None None 152965883 Common - Triose-phosphate isomerase Krad_1917 214 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 152964536 Common - glycosyl transferase family 2 Krad_0567 41 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152965156 Common - inner-membrane translocator Krad_1188 98 COG4214 XylH, ABC-type xylose transport system, permease component Carbohydrate transport and metabolism 152965356 Common - peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin Krad_1388 39 COG1876 VanY, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 152966106 Common - binding-protein-dependent transport systems inner membrane component Krad_2142 142 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152965494 Common - hypothetical protein Krad_1526 27 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 152964953 Common - hypothetical protein Krad_0985 11 None None None 152968236 Common - aminoglycoside phosphotransferase Krad_4293 61 COG3001 COG3001, Uncharacterized protein conserved in bacteria Function unknown 152967049 Nonpathogen - hypothetical protein Krad_3105 9 None None None 152965466 Common - ABC transporter-related protein Krad_1498 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 152968317 Common - Resolvase domain Krad_4374 133 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 152967532 Common - hypothetical protein Krad_3589 33 None None None 152966325 Nonpathogen - hypothetical protein Krad_2365 1 None None None 152966484 Common - regulatory protein LacI Krad_2529 123 COG1609 PurR, Transcriptional regulators Transcription 152967148 Common - UDP-N-acetylmuramyl-tripeptide synthetase Krad_3204 207 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 152966942 Common - extracellular solute-binding protein family 5 Krad_2998 198 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 152966889 Common - ABC transporter-related protein Krad_2945 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 152964559 Common - binding-protein-dependent transport systems inner membrane component Krad_0590 144 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152967800 Nonpathogen - hypothetical protein Krad_3857 3 None None None 152964576 Nonpathogen - Methyltransferase type 11 Krad_0607 11 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152965699 Common - hypothetical protein Krad_1733 2 None None None 152968075 Common - band 7 protein Krad_4132 11 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 152964736 Common - kinase-like protein Krad_0768 12 None None None 152965173 Common - Abortive infection protein Krad_1205 21 None None None 152964414 Common - hypothetical protein Krad_0444 16 COG3361 COG3361, Uncharacterized conserved protein Function unknown 152967514 Common - aldo/keto reductase Krad_3571 117 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 152967939 Common - phosphoribosylglycinamide formyltransferase Krad_3996 223 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 152966161 Nonpathogen - anti-sigma-factor antagonist Krad_2198 3 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 152966199 Nonpathogen - hypothetical protein Krad_2238 1 None None None 152964437 Common - hypothetical protein Krad_0467 13 COG5450 COG5450, Transcription regulator of the Arc/MetJ class Transcription 152968254 Common - cation diffusion facilitator family transporter Krad_4311 125 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 152964907 Common - extracellular solute-binding protein family 5 Krad_0939 175 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 152966062 Common - alpha/beta hydrolase fold Krad_2097 140 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152966546 Common - transcriptional regulator, XRE family Krad_2592 17 COG1396 HipB, Predicted transcriptional regulators Transcription 152967906 Common - binding-protein-dependent transport systems inner membrane component Krad_3963 160 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152966363 Nonpathogen - hypothetical protein Krad_2403 3 None None None 152964866 Common - transcriptional regulator, CarD family Krad_0898 83 COG1329 COG1329, Transcriptional regulators, similar to M. xanthus CarD Transcription 152966699 Common - binding-protein-dependent transport systems inner membrane component Krad_2747 174 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 152964846 Common - GCN5-related N-acetyltransferase Krad_0878 15 COG0456 RimI, Acetyltransferases General function prediction only 152968412 Nonpathogen - hypothetical protein Krad_4473 2 None None None 152967448 Common - acyl-CoA dehydrogenase domain protein Krad_3505 156 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 152964632 Common - ribosomal protein L33 Krad_0663 81 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 152965584 Common - PEBP family protein Krad_1618 117 COG1881 COG1881, Phospholipid-binding protein General function prediction only 152967198 Common - short-chain dehydrogenase/reductase SDR Krad_3254 203 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152964659 Common - Ribosomal protein L25/L23 Krad_0690 217 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 152968248 Common - ATP-dependent DNA helicase, RecQ family Krad_4305 212 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 152966727 Common - transcriptional regulator, MarR family Krad_2777 18 COG1846 MarR, Transcriptional regulators Transcription 152967385 Common - GCN5-related N-acetyltransferase Krad_3442 99 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 152965823 Common - tRNA methyltransferase complex GCD14 subunit Krad_1857 60 COG2519 GCD14, tRNA(1-methyladenosine) methyltransferase and related methyltransferases Translation, ribosomal structure and biogenesis 152964028 Common - ABC transporter-related protein Krad_0057 241 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 152964525 Nonpathogen - hypothetical protein Krad_0556 1 None None None 152965718 Nonpathogen - hypothetical protein Krad_1752 2 None None None 152964407 Common - diguanylate cyclase Krad_0437 172 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152964856 Common - D-tyrosyl-tRNA(Tyr) deacylase Krad_0888 139 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 152967475 Common - NmrA family protein Krad_3532 111 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152965327 Common - 3-isopropylmalate dehydratase, small subunit Krad_1359 209 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 152964129 Common - DNA-formamidopyrimidine glycosylase Krad_0158 181 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 152965797 Common - hypothetical protein Krad_1831 2 None None None 152967383 Common - hypothetical protein Krad_3440 14 None None None 152966252 Common - regulatory protein LuxR Krad_2291 24 COG3899 COG3899, Predicted ATPase General function prediction only 152967914 Common - transcriptional regulator, DeoR family Krad_3971 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 152964291 Common - response regulator receiver modulated CheB methylesterase Krad_0321 223 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 152965360 Common - signal recognition particle-docking protein FtsY Krad_1392 246 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 152966732 Common - thioesterase superfamily protein Krad_2782 60 COG0824 FcbC, Predicted thioesterase General function prediction only 152965927 Common - peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin Krad_1961 9 COG1876 VanY, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 152965388 Common - radical SAM enzyme, Cfr family Krad_1420 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 152966496 Common - Xylose isomerase domain protein TIM barrel Krad_2541 31 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 152968374 Common - stress protein Krad_4435 30 COG2310 TerZ, Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 Signal transduction mechanisms 152964282 Nonpathogen - protein of unknown function DUF742 Krad_0312 1 None None None 152966560 Nonpathogen - hypothetical protein Krad_2607 1 None None None 152967293 Common - hypothetical protein Krad_3349 7 None None None 152968319 Nonpathogen - hypothetical protein Krad_4376 5 None None None 152966963 Common - type IV pilus assembly protein PilM Krad_3019 77 COG4972 PilM, Tfp pilus assembly protein, ATPase PilM Cell motility and secretion / Intracellular trafficking and secretion 152968450 Common - protein of unknown function DUF37 Krad_4511 182 COG0759 COG0759, Uncharacterized conserved protein Function unknown 152967573 Common - molybdopterin biosynthesis MoaE protein Krad_3630 32 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 152968426 Common - ABC transporter-related protein Krad_4487 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 152967505 Common - hypothetical protein Krad_3562 4 None None None 152967378 Common - competence protein ComEA helix-hairpin-helix repeat protein Krad_3435 78 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 152965230 Nonpathogen - putative ATP synthase protein I Krad_1262 1 None None None 152966197 Common - putative cell wall binding repeat 2-containing protein Krad_2236 11 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 152966651 Common - hypothetical protein Krad_2699 13 None None None 152966014 Common - zinc finger SWIM domain protein Krad_2049 15 None None None 152968431 Nonpathogen - type IV pilus assembly PilZ Krad_4492 1 None None None 152965147 Common - UvrD/REP helicase Krad_1179 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 152964051 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_0080 90 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152967943 Common - Glycerone kinase Krad_4000 77 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 152967675 Common - binding-protein-dependent transport systems inner membrane component Krad_3732 145 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152965365 Common - amidohydrolase Krad_1397 44 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 152968384 Nonpathogen - hypothetical protein Krad_4445 2 None None None 152965312 Common - O-acetylhomoserine aminocarboxypropyltransferase Krad_1344 206 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 152965345 Common - formamidopyrimidine-DNA glycosylase Krad_1377 179 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 152966594 Nonpathogen - hypothetical protein Krad_2642 1 None None None 152967963 Common - two component transcriptional regulator, LuxR family Krad_4020 97 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152968106 Common - HAD-superfamily hydrolase, subfamily IIA Krad_4163 109 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 152966368 Nonpathogen - hypothetical protein Krad_2408 1 None None None 152965072 Common - Hly-III family protein Krad_1104 106 COG1272 COG1272, Predicted membrane protein, hemolysin III homolog General function prediction only 152964422 Common - ABC transporter-related protein Krad_0452 245 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 152964703 Common - hypothetical protein Krad_0734 22 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 152968438 Nonpathogen - ATP-binding region ATPase domain protein Krad_4499 4 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 152965697 Nonpathogen - hypothetical protein Krad_1731 2 None None None 152968108 Common - protein of unknown function DUF1025 Krad_4165 50 COG3824 COG3824, Uncharacterized protein conserved in bacteria Function unknown 152965669 Common - Fibronectin type III domain protein Krad_1703 2 None None None 152965942 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Krad_1976 18 COG0388 COG0388, Predicted amidohydrolase General function prediction only 152965750 Common - Alkaline phosphatase Krad_1784 59 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 152965413 Common - ribosome-binding factor A Krad_1445 145 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 152965418 Common - acyltransferase 3 Krad_1450 7 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 152965923 Nonpathogen - hypothetical protein Krad_1957 1 None None None 152964396 Common - Endoribonuclease L-PSP Krad_0426 90 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 152968327 Nonpathogen - hypothetical protein Krad_4385 2 None None None 152966725 Common - peptidase S41 Krad_2775 5 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 152966511 Common - hypothetical protein Krad_2556 4 COG1512 COG1512, Beta-propeller domains of methanol dehydrogenase type General function prediction only 152964921 Common - GCN5-related N-acetyltransferase Krad_0953 78 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 152965193 Common - hypothetical protein Krad_1225 18 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 152967591 Common - OsmC family protein Krad_3648 17 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 152965743 Nonpathogen - DNA binding domain, excisionase family Krad_1777 1 None None None 152968203 Common - transcriptional regulator, XRE family Krad_4260 18 COG1396 HipB, Predicted transcriptional regulators Transcription 152965845 Common - transcriptional regulator-like protein Krad_1879 50 COG2378 COG2378, Predicted transcriptional regulator Transcription 152968031 Common - major facilitator superfamily MFS_1 Krad_4088 174 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 152967669 Common - ABC transporter-related protein Krad_3726 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 152968335 Nonpathogen - PilT protein domain protein Krad_4396 5 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 152964936 Common - aldo/keto reductase Krad_0968 200 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152968025 Common - branched-chain amino acid aminotransferase Krad_4082 28 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 152964861 Nonpathogen - hypothetical protein Krad_0893 1 None None None 152967606 Nonpathogen - Capsular polysaccharide biosynthesis protein-like protein Krad_3663 10 COG4421 COG4421, Capsular polysaccharide biosynthesis protein Carbohydrate transport and metabolism 152966024 Common - GCN5-related N-acetyltransferase Krad_2059 129 COG2144 COG2144, Selenophosphate synthetase-related proteins General function prediction only 152966044 Common - amidase, hydantoinase/carbamoylase family Krad_2079 84 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 152966606 Common - NADP oxidoreductase coenzyme F420-dependent Krad_2654 21 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 152968090 Common - extracellular solute-binding protein family 1 Krad_4147 57 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152966713 Common - diguanylate cyclase/phosphodiesterase Krad_2761 177 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152965382 Common - aminotransferase class I and II Krad_1414 236 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 152965519 Common - Inositol-phosphate phosphatase Krad_1553 166 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 152965711 Nonpathogen - hypothetical protein Krad_1745 1 None None None 152965790 Common - cytidyltransferase-related domain Krad_1824 96 COG0615 TagD, Cytidylyltransferase Cell envelope biogenesis, outer membrane / Lipid metabolism 152967742 Common - hypothetical protein Krad_3799 7 None None None 152965966 Common - ABC transporter-related protein Krad_2001 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 152966920 Common - phosphoribosyl-ATP pyrophosphohydrolase Krad_2976 18 COG0140 HisI, Phosphoribosyl-ATP pyrophosphohydrolase Amino acid transport and metabolism 152966809 Common - major facilitator superfamily MFS_1 Krad_2863 21 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152966906 Common - prolipoprotein diacylglyceryl transferase Krad_2962 71 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 152964059 Common - diguanylate cyclase/phosphodiesterase Krad_0088 166 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152964712 Common - IMP dehydrogenase family protein Krad_0743 193 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 152966157 Common - Stage II sporulation E family protein Krad_2194 83 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152968180 Common - ABC transporter, permease protein Krad_4237 9 COG4721 COG4721, Predicted membrane protein Function unknown 152965759 Common - Alcohol dehydrogenase GroES domain protein Krad_1793 205 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 152964031 Common - short-chain dehydrogenase/reductase SDR Krad_0060 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152966528 Common - short-chain dehydrogenase/reductase SDR Krad_2573 231 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 152965140 Common - UvrD/REP helicase Krad_1172 218 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 152967855 Common - Carbamoyl-phosphate synthase L chain ATP-binding Krad_3912 234 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 152966118 Common - hypothetical protein Krad_2154 6 None None None 152967348 Common - methyl-accepting chemotaxis sensory transducer Krad_3404 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152968397 Common - transcriptional regulator, TetR family Krad_4458 37 COG1309 AcrR, Transcriptional regulator Transcription 152964818 Common - aldo/keto reductase Krad_0850 189 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152966211 Nonpathogen - hypothetical protein Krad_2250 1 None None None 152965991 Nonpathogen - hypothetical protein Krad_2026 1 None None None 152965614 Common - protein of unknown function DUF1078 domain protein Krad_1648 118 COG1558 FlgC, Flagellar basal body rod protein Cell motility and secretion 152963989 Common - glycosyl transferase group 1 Krad_0017 168 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152965319 Common - integral membrane sensor signal transduction histidine kinase Krad_1351 129 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152965659 Nonpathogen - hypothetical protein Krad_1693 1 None None None 152967256 Common - protein of unknown function DUF124 Krad_3312 69 COG2013 COG2013, Uncharacterized conserved protein Function unknown 152964373 Common - putative metalloendopeptidase, glycoprotease family Krad_0403 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 152965690 Common - hypothetical protein Krad_1724 2 None None None 152966111 Nonpathogen - hypothetical protein Krad_2147 8 COG1649 COG1649, Uncharacterized protein conserved in bacteria Function unknown 152967335 Common - para-aminobenzoate synthase, subunit I Krad_3391 229 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 152965100 Common - choline/carnitine/betaine transporter Krad_1132 96 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 152965241 Nonpathogen - hypothetical protein Krad_1273 1 None None None 152965404 Common - prolyl-tRNA synthetase Krad_1436 246 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152966128 Common - extracellular solute-binding protein family 1 Krad_2164 87 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152966634 Common - hypothetical protein Krad_2682 7 None None None 152968407 Nonpathogen - hypothetical protein Krad_4468 1 None None None 152966101 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Krad_2137 13 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 152964097 Common - riboflavin biosynthesis protein RibD Krad_0126 229 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 152965971 Common - response regulator receiver and ANTAR domain protein Krad_2006 15 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 152968098 Common - periplasmic binding protein/LacI transcriptional regulator Krad_4155 21 COG1609 PurR, Transcriptional regulators Transcription 152968241 Common - sodium/hydrogen exchanger Krad_4298 31 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 152967193 Common - anthranilate phosphoribosyltransferase Krad_3249 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 152967563 Common - two component transcriptional regulator, winged helix family Krad_3620 218 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152967240 Common - glutamine synthetase, type I Krad_3296 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 152968309 Common - 4-hydroxythreonine-4-phosphate dehydrogenase Krad_4366 160 COG1995 PdxA, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 152968044 Common - membrane protein-like protein Krad_4101 12 COG4129 COG4129, Predicted membrane protein Function unknown 152964775 Common - periplasmic binding protein Krad_0807 52 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 152966074 Common - integral membrane sensor signal transduction histidine kinase Krad_2109 142 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152966834 Nonpathogen - hypothetical protein Krad_2889 1 None None None 152966310 Common - pentapeptide repeat protein Krad_2350 56 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 152966823 Nonpathogen - GCN5-related N-acetyltransferase Krad_2877 5 COG0456 RimI, Acetyltransferases General function prediction only 152967466 Common - hypothetical protein Krad_3523 17 COG4923 COG4923, Uncharacterized conserved protein Function unknown 152967136 Common - hypothetical protein Krad_3192 16 None None None 152966573 Nonpathogen - hypothetical protein Krad_2620 1 None None None 152964352 Common - hypothetical protein Krad_0382 7 COG4127 COG4127, Uncharacterized conserved protein Function unknown 152968160 Common - two component transcriptional regulator, LuxR family Krad_4217 174 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152964046 Common - Protein phosphatase 2C-like protein Krad_0075 137 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 152967096 Common - hypothetical protein Krad_3152 28 COG4198 COG4198, Uncharacterized conserved protein Function unknown 152968001 Common - hypothetical protein Krad_4058 13 None None None 152967728 Common - TadE family protein Krad_3785 7 None None None 152968124 Common - hypothetical protein Krad_4181 30 COG0824 FcbC, Predicted thioesterase General function prediction only 152964196 Common - fatty acid desaturase Krad_0225 30 COG3239 DesA, Fatty acid desaturase Lipid metabolism 152965422 Common - short-chain dehydrogenase/reductase SDR Krad_1454 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152965779 Common - ABC transporter-related protein Krad_1813 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 152967893 Common - amidohydrolase Krad_3950 164 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 152965530 Common - deoxyribonuclease/rho motif-related TRAM Krad_1564 178 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 152967055 Common - NMT1/THI5 like domain protein Krad_3111 38 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 152967814 Common - UDP-glucose 4-epimerase Krad_3871 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 152964133 Common - hypothetical protein Krad_0162 12 None None None 152965127 Common - Ferritin Dps family protein Krad_1159 93 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 152964333 Common - membrane protein-like protein Krad_0363 3 COG3463 COG3463, Predicted membrane protein Function unknown 152964091 Nonpathogen - hypothetical protein Krad_0120 1 None None None 152966004 Nonpathogen - major facilitator superfamily MFS_1 Krad_2039 3 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152965684 Nonpathogen - hypothetical protein Krad_1718 1 None None None 152965706 Nonpathogen - hypothetical protein Krad_1740 1 None None None 152967275 Common - two component transcriptional regulator, LuxR family Krad_3331 154 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152967801 Nonpathogen - hypothetical protein Krad_3858 1 None None None 152967834 Nonpathogen - hypothetical protein Krad_3891 1 None None None 152967709 Common - ATP-dependent Clp protease adaptor protein ClpS Krad_3766 17 COG2127 COG2127, Uncharacterized conserved protein Function unknown 152966447 Nonpathogen - hypothetical protein Krad_2491 1 None None None 152965680 Common - hypothetical protein Krad_1714 3 None None None 152964901 Nonpathogen - hypothetical protein Krad_0933 1 None None None 152966108 Common - extracellular solute-binding protein family 1 Krad_2144 33 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152967370 Common - glycosyl transferase group 1 Krad_3427 209 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152964660 Common - ribosomal protein L2 Krad_0691 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 152965878 Nonpathogen - hypothetical protein Krad_1912 1 None None None 152964688 Common - ABC transporter-related protein Krad_0719 246 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 152965501 Common - hypothetical protein Krad_1533 11 None None None 152966052 Common - short-chain dehydrogenase/reductase SDR Krad_2087 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152966535 Common - short-chain dehydrogenase/reductase SDR Krad_2580 236 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152964343 Common - Alcohol dehydrogenase zinc-binding domain protein Krad_0373 110 COG2130 COG2130, Putative NADP-dependent oxidoreductases General function prediction only 152966491 Common - putative membrane transport protein Krad_2536 40 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 152967315 Common - histone family protein DNA-binding protein Krad_3371 198 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 152966516 Nonpathogen - hypothetical protein Krad_2561 2 None None None 152967026 Common - deoxyribodipyrimidine photolyase-related protein Krad_3082 59 COG3046 COG3046, Uncharacterized protein related to deoxyribodipyrimidine photolyase General function prediction only 152964835 Common - short-chain dehydrogenase/reductase SDR Krad_0867 234 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152966718 Nonpathogen - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_2767 5 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152968193 Common - Thymidine kinase Krad_4250 73 COG1435 Tdk, Thymidine kinase Nucleotide transport and metabolism 152965727 Nonpathogen - hypothetical protein Krad_1761 1 None None None 152967762 Common - ATPase associated with various cellular activities AAA_3 Krad_3819 171 COG0714 COG0714, MoxR-like ATPases General function prediction only 152968110 Common - carbon starvation protein CstA Krad_4167 107 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 152966248 Common - hypothetical protein Krad_2287 10 None None None 152965275 Common - aminotransferase class V Krad_1307 224 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 152964628 Common - protein serine phosphatase with GAF(s) sensor(s) Krad_0659 30 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152965606 Common - ABC transporter CydDC cysteine exporter (CydDC-E) family permease/ATP-binding protein CydD Krad_1640 231 COG4988 CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 152967163 Nonpathogen - hypothetical protein Krad_3219 1 None None None 152965468 Common - tRNA delta(2)-isopentenylpyrophosphate transferase Krad_1500 213 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 152964367 Common - transcriptional regulator, TetR family Krad_0397 14 COG1309 AcrR, Transcriptional regulator Transcription 152965129 Common - Xaa-Pro aminopeptidase Krad_1161 222 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 152965047 Common - Uracil-DNA glycosylase superfamily Krad_1079 59 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 152964528 Nonpathogen - hypothetical protein Krad_0559 3 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 152966769 Nonpathogen - hypothetical protein Krad_2819 1 None None None 152964823 Common - transcriptional activator, TenA family Krad_0855 39 COG0819 TenA, Putative transcription activator Transcription 152965004 Common - hypothetical protein Krad_1036 3 None None None 152968308 Common - transcriptional regulator, DeoR family Krad_4365 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 152967286 Common - putative transcriptional regulator, PucR family Krad_3342 17 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 152965396 Common - peptidase M50 Krad_1428 202 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 152968386 Common - glycosyl transferase family 2 Krad_4447 17 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 152966735 Common - phosphonate ABC transporter, periplasmic phosphonate-binding protein Krad_2785 55 COG3221 PhnD, ABC-type phosphate/phosphonate transport system, periplasmic component Inorganic ion transport and metabolism 152967267 Common - OsmC family protein Krad_3323 88 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 152964111 Common - putative transcriptional regulator, MerR family Krad_0140 113 COG0789 SoxR, Predicted transcriptional regulators Transcription 152968073 Common - FAD linked oxidase domain protein Krad_4130 207 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 152966373 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_2413 6 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152967221 Nonpathogen - hypothetical protein Krad_3277 3 None None None 152968446 Common - Cobyrinic acid ac-diamide synthase Krad_4507 199 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 152964579 Common - pyrroline-5-carboxylate reductase Krad_0610 214 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 152968144 Common - hypothetical protein Krad_4201 15 COG4954 COG4954, Uncharacterized protein conserved in bacteria Function unknown 152967989 Common - glycine cleavage system T protein Krad_4046 179 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 152967889 Common - inner-membrane translocator Krad_3946 107 COG1079 COG1079, Uncharacterized ABC-type transport system, permease component General function prediction only 152967793 Common - transcription factor WhiB Krad_3850 19 None None None 152966059 Common - ABC transporter-related protein Krad_2094 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 152968256 Common - putative integral membrane protein Krad_4313 13 None None None 152965080 Common - fumarate lyase Krad_1112 224 COG0114 FumC, Fumarase Energy production and conversion 152966176 Nonpathogen - hypothetical protein Krad_2215 1 None None None 152967815 Common - Auxin Efflux Carrier Krad_3872 19 COG0679 COG0679, Predicted permeases General function prediction only 152967204 Common - Leucyltransferase Krad_3260 134 COG2360 Aat, Leu/Phe-tRNA-protein transferase Posttranslational modification, protein turnover, chaperones 152968009 Nonpathogen - hypothetical protein Krad_4066 1 None None None 152964434 Nonpathogen - hypothetical protein Krad_0464 4 None None None 152965233 Common - ATP synthase F0, C subunit Krad_1265 96 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 152968409 Common - protein of unknown function DUF322 Krad_4470 37 COG1302 COG1302, Uncharacterized protein conserved in bacteria Function unknown 152965055 Common - protein of unknown function DUF993 Krad_1087 21 None None None 152965303 Common - acetolactate synthase, large subunit, biosynthetic type Krad_1335 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 152967798 Nonpathogen - protein of unknown function DUF6 transmembrane Krad_3855 5 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 152966689 Common - Alpha/beta hydrolase fold-3 domain protein Krad_2737 108 COG0657 Aes, Esterase/lipase Lipid metabolism 152965802 Common - Cysteine--tRNA ligase Krad_1836 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152967050 Common - peptidase C60 sortase A and B Krad_3106 13 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 152966953 Common - translation elongation factor P Krad_3009 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 152967579 Common - chaperonin GroEL Krad_3636 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 152964916 Nonpathogen - hypothetical protein Krad_0948 1 None None None 152967835 Nonpathogen - glycosyl transferase group 1 Krad_3892 1 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152968085 Common - YCII-related Krad_4142 6 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 152967643 Common - carbohydrate kinase, YjeF related protein Krad_3700 142 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 152966974 Common - aminodeoxychorismate lyase Krad_3030 185 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 152967484 Common - diguanylate cyclase Krad_3541 176 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152965646 Common - NAD-dependent epimerase/dehydratase Krad_1680 139 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152964568 Common - HhH-GPD family protein Krad_0599 203 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 152966844 Common - glycogen synthase Krad_2900 132 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152966565 Nonpathogen - hypothetical protein Krad_2612 1 None None None 152966244 Nonpathogen - hypothetical protein Krad_2283 1 None None None 152965932 Nonpathogen - hypothetical protein Krad_1966 1 None None None 152967072 Nonpathogen - hypothetical protein Krad_3128 1 None None None 152965662 Common - WD40 domain protein beta Propeller Krad_1696 40 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 152966617 Nonpathogen - hypothetical protein Krad_2665 1 None None None 152967281 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Krad_3337 52 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 152964175 Common - Mg2 transporter protein CorA family protein Krad_0204 160 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 152964380 Common - binding-protein-dependent transport systems inner membrane component Krad_0410 139 COG4209 LplB, ABC-type polysaccharide transport system, permease component Carbohydrate transport and metabolism 152966268 Common - protein of unknown function DUF1486 Krad_2307 12 COG5485 COG5485, Predicted ester cyclase General function prediction only 152964584 Common - glutaredoxin 2 Krad_0615 20 None None None 152965031 Common - glycoside hydrolase family 5 Krad_1063 14 COG3867 COG3867, Arabinogalactan endo-1,4-beta-galactosidase Carbohydrate transport and metabolism 152965508 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Krad_1542 8 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152965214 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Krad_1246 77 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 152967691 Common - putative secreted protein Krad_3748 19 None None None 152965897 Common - Beta-lactamase Krad_1931 60 COG2367 PenP, Beta-lactamase class A Defense mechanisms 152964546 Nonpathogen - hypothetical protein Krad_0577 1 None None None 152965590 Nonpathogen - hypothetical protein Krad_1624 1 None None None 152966238 Nonpathogen - hypothetical protein Krad_2277 1 None None None 152965922 Common - putative transcriptional regulator, XRE family Krad_1956 41 COG1396 HipB, Predicted transcriptional regulators Transcription 152965781 Common - amino acid permease-associated region Krad_1815 177 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 152968271 Common - hypothetical protein Krad_4328 19 None None None 152966357 Nonpathogen - hypothetical protein Krad_2397 1 None None None 152964002 Common - cell envelope-related transcriptional attenuator Krad_0030 63 COG1316 LytR, Transcriptional regulator Transcription 152965828 Common - ribonuclease BN Krad_1862 6 COG1295 Rbn, Predicted membrane protein Function unknown 152967992 Common - hypothetical protein Krad_4049 30 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152965211 Nonpathogen - hypothetical protein Krad_1243 1 None None None 152967458 Common - ATP-dependent Clp protease, ATP-binding subunit ClpX Krad_3515 223 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 152966224 Common - hypothetical protein Krad_2263 6 None None None 152965645 Common - hypothetical protein Krad_1679 22 COG4850 COG4850, Uncharacterized conserved protein Function unknown 152965857 Nonpathogen - FxsA cytoplasmic membrane protein Krad_1891 1 COG3030 FxsA, Protein affecting phage T7 exclusion by the F plasmid General function prediction only 152964087 Common - binding-protein-dependent transport systems inner membrane component Krad_0116 153 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152965582 Nonpathogen - hypothetical protein Krad_1616 7 None None None 152967014 Common - glycosyl transferase group 1 Krad_3070 83 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152964530 Common - transferase hexapeptide repeat containing protein Krad_0561 216 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 152965884 Common - ribose 5-phosphate isomerase Krad_1918 120 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 152966787 Common - OmpA/MotB domain protein Krad_2839 119 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 152967127 Common - ybaK/ebsC protein Krad_3183 100 COG2606 EbsC, Uncharacterized conserved protein Function unknown 152964456 Common - methyltransferase small Krad_0486 21 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 152966212 Nonpathogen - hypothetical protein Krad_2251 1 None None None 152967112 Common - ribosomal protein L35 Krad_3168 183 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 152967859 Common - integral membrane sensor signal transduction histidine kinase Krad_3916 37 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152967944 Nonpathogen - hypothetical protein Krad_4001 1 None None None 152964374 Common - Uncharacterized protein involved in stress response Krad_0404 18 COG4110 COG4110, Uncharacterized protein involved in stress response General function prediction only 152964902 Common - Rhodanese domain protein Krad_0934 19 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152967576 Common - hypothetical protein Krad_3633 7 None None None 152967999 Common - thiamine pyrophosphate protein central region Krad_4056 221 COG3962 COG3962, Acetolactate synthase Amino acid transport and metabolism 152964841 Common - phosphate ABC transporter, inner membrane subunit PstA Krad_0873 226 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 152968296 Nonpathogen - hypothetical protein Krad_4353 1 None None None 152964658 Common - ribosomal protein L4/L1e Krad_0689 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 152966365 Common - NmrA family protein Krad_2405 18 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152968325 Common - 6-pyruvoyl tetrahydropterin synthase and hypothetical protein Krad_4382 131 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 152967533 Common - hypothetical protein Krad_3590 9 None None None 152968418 Common - luciferase family protein Krad_4479 67 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152965557 Nonpathogen - membrane protein-like protein Krad_1591 1 COG4270 COG4270, Predicted membrane protein Function unknown 152965200 Nonpathogen - hypothetical protein Krad_1232 3 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152966461 Common - short-chain dehydrogenase/reductase SDR Krad_2506 171 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152967407 Common - putative alpha-galactosidase Krad_3464 14 COG3345 GalA, Alpha-galactosidase Carbohydrate transport and metabolism 152968414 Nonpathogen - hypothetical protein Krad_4475 1 None None None 152965199 Common - IMP dehydrogenase family protein Krad_1231 233 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 152965889 Common - GCN5-related N-acetyltransferase Krad_1923 7 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 152966692 Common - diguanylate cyclase Krad_2740 192 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152966979 Common - AAA ATPase central domain protein Krad_3035 203 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 152966687 Common - putative transcriptional regulator, MerR family Krad_2735 48 COG0789 SoxR, Predicted transcriptional regulators Transcription 152965831 Common - aminotransferase class V Krad_1865 63 COG3844 COG3844, Kynureninase Amino acid transport and metabolism 152964893 Common - flavin reductase domain protein FMN-binding Krad_0925 74 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 152966670 Common - helix-turn-helix domain protein Krad_2718 41 None None None 152968133 Common - binding-protein-dependent transport systems inner membrane component Krad_4190 147 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152965625 Common - flagellar FlbD family protein Krad_1659 28 COG1582 FlgEa, Uncharacterized protein, possibly involved in motility Cell motility and secretion 152967646 Common - transport system permease protein Krad_3703 137 COG4606 CeuB, ABC-type enterochelin transport system, permease component Inorganic ion transport and metabolism 152964569 Common - hypothetical protein Krad_0600 14 None None None 152965025 Common - glycosyl transferase family 2 Krad_1057 187 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152966467 Nonpathogen - hypothetical protein Krad_2512 1 None None None 152968074 Common - hypothetical protein Krad_4131 11 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 152966721 Nonpathogen - hypothetical protein Krad_2771 2 None None None 152965482 Common - phosphodiesterase, MJ0936 family Krad_1514 32 COG0622 COG0622, Predicted phosphoesterase General function prediction only 152967349 Common - chaperone protein DnaJ Krad_3405 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 152966941 Common - binding-protein-dependent transport systems inner membrane component Krad_2997 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 152965776 Nonpathogen - hypothetical protein Krad_1810 1 None None None 152966691 Common - short-chain dehydrogenase/reductase SDR Krad_2739 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152965822 Common - peptidase M50 Krad_1856 18 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 152964299 Nonpathogen - hypothetical protein Krad_0329 1 None None None 152965392 Common - 4-aminobutyrate aminotransferase Krad_1424 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 152966222 Nonpathogen - hypothetical protein Krad_2261 1 None None None 152966903 Common - pyruvate kinase Krad_2959 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 152967476 Common - globin Krad_3533 67 COG2346 COG2346, Truncated hemoglobins General function prediction only 152967041 Common - glycine cleavage system H protein Krad_3097 185 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 152966060 Common - methyl-accepting chemotaxis sensory transducer Krad_2095 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152967087 Common - virulence factor MVIN family protein Krad_3143 3 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 152964966 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Krad_0998 179 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 152966501 Common - transcriptional regulator, TetR family Krad_2546 32 COG1309 AcrR, Transcriptional regulator Transcription 152967785 Nonpathogen - hypothetical protein Krad_3842 2 None None None 152967908 Common - Alanine racemase Krad_3965 127 COG1609 PurR, Transcriptional regulators Transcription 152967424 Common - oxidoreductase domain protein Krad_3481 6 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152966084 Common - alpha/beta hydrolase fold Krad_2119 61 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152966100 Common - transcriptional regulator, LysR family Krad_2136 93 COG0583 LysR, Transcriptional regulator Transcription 152964316 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Krad_0346 9 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152966917 Common - hypothetical protein Krad_2973 6 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 152965838 Common - protein of unknown function DUF797 Krad_1872 14 None None None 152964586 Common - Glutamyl-tRNA reductase Krad_0617 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 152967772 Common - protein of unknown function DUF95 transmembrane Krad_3829 37 COG1300 SpoIIM, Uncharacterized membrane protein Function unknown 152965158 Common - hypothetical protein Krad_1190 26 COG5282 COG5282, Uncharacterized conserved protein Function unknown 152965912 Common - short-chain dehydrogenase/reductase SDR Krad_1946 238 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152967074 Nonpathogen - hypothetical protein Krad_3130 5 None None None 152965000 Common - N-acyl-D-amino-acid deacylase Krad_1032 51 COG3653 COG3653, N-acyl-D-aspartate/D-glutamate deacylase Secondary metabolites biosynthesis, transport, and catabolism 152965514 Common - CoA-binding domain protein Krad_1548 157 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 152964074 Common - hypothetical protein Krad_0103 5 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 152964593 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Krad_0624 40 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 152966553 Common - integral membrane sensor signal transduction histidine kinase Krad_2600 54 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152966948 Common - dihydroorotase, multifunctional complex type Krad_3004 213 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 152967696 Common - Endoribonuclease L-PSP Krad_3753 172 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 152964034 Common - SpoOM family protein Krad_0063 20 COG4326 Spo0M, Sporulation control protein General function prediction only 152964149 Common - diguanylate cyclase Krad_0178 176 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152968010 Nonpathogen - hypothetical protein Krad_4067 1 None None None 152964329 Common - peptidase S8 and S53 subtilisin kexin sedolisin Krad_0359 113 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 152964952 Common - oxidoreductase domain protein Krad_0984 81 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152966006 Nonpathogen - hypothetical protein Krad_2041 2 None None None 152966088 Common - inner-membrane translocator Krad_2124 103 COG1079 COG1079, Uncharacterized ABC-type transport system, permease component General function prediction only 152965285 Common - glutamyl-tRNA(Gln) amidotransferase, C subunit Krad_1317 83 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 152965471 Common - small GTP-binding protein Krad_1503 233 COG2262 HflX, GTPases General function prediction only 152968012 Common - phosphoribosylformylglycinamidine synthase I Krad_4069 230 COG0047 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain Nucleotide transport and metabolism 152966162 Nonpathogen - hypothetical protein Krad_2199 1 None None None 152964237 Common - transcriptional regulator, TetR family Krad_0267 24 COG1309 AcrR, Transcriptional regulator Transcription 152964108 Common - NmrA family protein Krad_0137 53 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152967832 Common - acyltransferase 3 Krad_3889 40 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 152967230 Common - luciferase family protein Krad_3286 77 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152964848 Nonpathogen - hypothetical protein Krad_0880 1 None None None 152964990 Common - Transcriptional regulator IclR Krad_1022 92 COG1414 IclR, Transcriptional regulator Transcription 152968274 Common - diguanylate cyclase with PAS/PAC sensor Krad_4331 187 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152967554 Nonpathogen - hypothetical protein Krad_3611 1 None None None 152965539 Nonpathogen - hypothetical protein Krad_1573 1 None None None 152967080 Nonpathogen - SAF domain protein Krad_3136 1 None None None 152966724 Nonpathogen - hypothetical protein Krad_2774 1 None None None 152965917 Common - Alcohol dehydrogenase GroES domain protein Krad_1951 118 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 152965125 Common - protein of unknown function DUF1003 Krad_1157 17 COG4420 COG4420, Predicted membrane protein Function unknown 152966330 Nonpathogen - hypothetical protein Krad_2370 1 None None None 152967303 Common - zinc finger CDGSH-type domain protein Krad_3359 6 None None None 152967970 Common - short-chain dehydrogenase/reductase SDR Krad_4027 233 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152964143 Common - response regulator receiver protein Krad_0172 2 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152967803 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Krad_3860 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 152965810 Nonpathogen - hypothetical protein Krad_1844 1 None None None 152967656 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Krad_3713 11 None None None 152965349 Common - ROK family protein Krad_1381 121 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 152964911 Common - GCN5-related N-acetyltransferase Krad_0943 20 COG3393 COG3393, Predicted acetyltransferase General function prediction only 152966146 Common - putative transcriptional regulator, MerR family Krad_2183 42 COG0789 SoxR, Predicted transcriptional regulators Transcription 152963992 Nonpathogen - hypothetical protein Krad_0020 1 None None None 152965460 Common - recA protein Krad_1492 235 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 152965151 Common - hypothetical protein Krad_1183 10 None None None 152964491 Common - transcriptional regulator, TetR family Krad_0522 24 COG1309 AcrR, Transcriptional regulator Transcription 152965375 Common - protein of unknown function UPF0102 Krad_1407 134 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 152967371 Nonpathogen - protein of unknown function DUF181 Krad_3428 13 COG1944 COG1944, Uncharacterized conserved protein Function unknown 152965980 Common - putative transcriptional regulator, MerR family Krad_2015 57 COG0789 SoxR, Predicted transcriptional regulators Transcription 152964802 Common - urease, gamma subunit Krad_0834 96 COG0831 UreA, Urea amidohydrolase (urease) gamma subunit Amino acid transport and metabolism 152965280 Common - GCN5-related N-acetyltransferase Krad_1312 21 COG0456 RimI, Acetyltransferases General function prediction only 152965982 Common - ABC transporter-related protein Krad_2017 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 152964132 Common - putative cell wall binding repeat 2-containing protein Krad_0161 6 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 152966967 Nonpathogen - hypothetical protein Krad_3023 1 COG4967 PilV, Tfp pilus assembly protein PilV Cell motility and secretion / Intracellular trafficking and secretion 152966712 Common - glutaredoxin Krad_2760 19 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 152967120 Common - histidinol-phosphate aminotransferase Krad_3176 237 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 152965172 Common - UspA domain protein Krad_1204 8 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 152965777 Nonpathogen - hypothetical protein Krad_1811 1 None None None 152967106 Common - short-chain dehydrogenase/reductase SDR Krad_3162 27 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 152965561 Common - protein of unknown function DUF322 Krad_1595 38 COG1302 COG1302, Uncharacterized protein conserved in bacteria Function unknown 152965179 Common - protein of unknown function DUF159 Krad_1211 65 COG2135 COG2135, Uncharacterized conserved protein Function unknown 152967269 Nonpathogen - hypothetical protein Krad_3325 1 None None None 152964613 Common - protein of unknown function DUF470 Krad_0644 78 COG2898 COG2898, Uncharacterized conserved protein Function unknown 152966745 Nonpathogen - hypothetical protein Krad_2795 1 None None None 152965576 Common - diguanylate cyclase Krad_1610 176 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152967872 Nonpathogen - hypothetical protein Krad_3929 1 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 152966137 Nonpathogen - hypothetical protein Krad_2174 1 None None None 152966930 Nonpathogen - hypothetical protein Krad_2986 1 None None None 152964357 Common - binding-protein-dependent transport systems inner membrane component Krad_0387 169 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152968269 Common - DNA-directed DNA polymerase Krad_4326 185 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 152965207 Common - ABC transporter-related protein Krad_1239 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 152967567 Common - hypothetical protein Krad_3624 4 COG4842 COG4842, Uncharacterized protein conserved in bacteria Function unknown 152965694 Nonpathogen - hypothetical protein Krad_1728 1 None None None 152965732 Common - transcription factor WhiB Krad_1766 19 None None None 152968281 Common - single-strand binding protein Krad_4338 202 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 152967260 Common - toxic anion resistance family protein Krad_3316 36 COG3853 TelA, Uncharacterized protein involved in tellurite resistance Inorganic ion transport and metabolism 152966470 Common - restriction endonuclease Krad_2515 15 COG1787 COG1787, Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes Defense mechanisms 152966196 Common - LrgB family protein Krad_2235 84 COG1346 LrgB, Putative effector of murein hydrolase Cell envelope biogenesis, outer membrane 152964787 Common - Rieske (2Fe-2S) domain protein Krad_0819 19 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 152965704 Nonpathogen - hypothetical protein Krad_1738 1 None None None 152966159 Common - phospholipase D/Transphosphatidylase Krad_2196 27 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 152966026 Common - hypothetical protein Krad_2061 17 None None None 152967539 Nonpathogen - hypothetical protein Krad_3596 3 None None None 152964224 Common - hypothetical protein Krad_0254 3 None None None 152965441 Common - beta-phosphoglucomutase family hydrolase Krad_1473 74 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 152966679 Common - glucose-methanol-choline oxidoreductase Krad_2727 94 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 152968054 Common - cutinase Krad_4111 4 None None None 152966952 Common - NusB antitermination factor Krad_3008 176 COG0781 NusB, Transcription termination factor Transcription 152965320 Common - 3-isopropylmalate dehydrogenase Krad_1352 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 152967932 Common - carboxyl transferase Krad_3989 217 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 152964977 Common - FAD dependent oxidoreductase Krad_1009 149 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 152966067 Common - protein of unknown function DUF204 Krad_2102 64 COG1971 COG1971, Predicted membrane protein Function unknown 152967615 Nonpathogen - hypothetical protein Krad_3672 1 COG3944 COG3944, Capsular polysaccharide biosynthesis protein Cell envelope biogenesis, outer membrane 152967001 Common - protein of unknown function DUF28 Krad_3057 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 152967171 Common - Polyprenyl synthetase Krad_3227 225 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 152965142 Common - Endonuclease/exonuclease/phosphatase Krad_1174 6 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 152964601 Nonpathogen - hypothetical protein Krad_0632 1 COG2213 MtlA, Phosphotransferase system, mannitol-specific IIBC component Carbohydrate transport and metabolism 152966097 Common - 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase Krad_2133 125 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 152966543 Common - short-chain dehydrogenase/reductase SDR Krad_2589 236 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152965045 Common - protein of unknown function DUF419 Krad_1077 14 COG2315 MmcQ, Uncharacterized protein conserved in bacteria Function unknown 152966394 Common - Pyruvate, water dikinase Krad_2434 152 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 152967415 Common - ROK family protein Krad_3472 85 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 152967574 Common - hypothetical protein Krad_3631 13 COG1920 COG1920, Uncharacterized conserved protein Function unknown 152965092 Common - GTP-binding protein YchF Krad_1124 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 152965496 Common - hypothetical protein Krad_1528 11 None None None 152967236 Common - hypothetical protein Krad_3292 4 None None None 152966234 Nonpathogen - hypothetical protein Krad_2273 1 None None None 152964390 Common - peptidase S1 and S6 chymotrypsin/Hap Krad_0420 117 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 152964705 Common - chaperonin GroEL Krad_0736 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 152967239 Common - (Glutamate--ammonia-ligase) adenylyltransferase Krad_3295 119 COG1391 GlnE, Glutamine synthetase adenylyltransferase Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms 152967103 Common - acetylglutamate kinase Krad_3159 220 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 152965099 Common - NUDIX hydrolase Krad_1131 10 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 152967867 Common - cobalamin synthesis protein P47K Krad_3924 125 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 152965791 Common - Fibronectin type III domain protein Krad_1825 14 None None None 152965469 Common - Diaminopimelate epimerase Krad_1501 169 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 152967215 Common - protein of unknown function DUF779 Krad_3271 42 COG3564 COG3564, Uncharacterized protein conserved in bacteria Function unknown 152968089 Common - binding-protein-dependent transport systems inner membrane component Krad_4146 143 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152968234 Common - histidinol-phosphate aminotransferase Krad_4291 240 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 152966338 Nonpathogen - hypothetical protein Krad_2378 1 None None None 152968142 Nonpathogen - hypothetical protein Krad_4199 1 None None None 152964565 Common - GCN5-related N-acetyltransferase Krad_0596 112 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 152967457 Common - YceI family protein Krad_3514 116 COG2353 COG2353, Uncharacterized conserved protein Function unknown 152964276 Common - heat shock protein Hsp20 Krad_0306 134 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 152968229 Common - catalytic domain of components of various dehydrogenase complexes Krad_4286 196 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 152967543 Common - protein of unknown function DUF6 transmembrane Krad_3600 5 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 152966583 Nonpathogen - hypothetical protein Krad_2631 2 None None None 152964729 Common - beta-lactamase domain protein Krad_0760 151 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 152968422 Common - Proline dehydrogenase Krad_4483 117 COG0506 PutA, Proline dehydrogenase Amino acid transport and metabolism 152964523 Nonpathogen - hypothetical protein Krad_0554 1 None None None 152966298 Nonpathogen - hypothetical protein Krad_2338 1 None None None 152967365 Common - ribosomal protein S20 Krad_3421 23 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 152965952 Common - putative GAF sensor protein Krad_1986 50 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 152964182 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_0211 83 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152966799 Nonpathogen - hypothetical protein Krad_2852 1 None None None 152967450 Common - diguanylate cyclase Krad_3507 176 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152967141 Common - Polypeptide-transport-associated domain protein FtsQ-type Krad_3197 16 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 152964506 Common - transcriptional regulator, GntR family Krad_0537 118 COG1802 GntR, Transcriptional regulators Transcription 152965054 Common - oxidoreductase domain protein Krad_1086 33 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152967921 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Krad_3978 218 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 152966885 Common - transcriptional regulator, MarR family Krad_2941 16 COG1846 MarR, Transcriptional regulators Transcription 152964004 Common - Alanine racemase Krad_0032 125 COG1609 PurR, Transcriptional regulators Transcription 152964110 Common - short-chain dehydrogenase/reductase SDR Krad_0139 83 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152964879 Common - cysteinyl-tRNA synthetase Krad_0911 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152964984 Common - potassium-transporting ATPase, A subunit Krad_1016 96 COG2060 KdpA, K+-transporting ATPase, A chain Inorganic ion transport and metabolism 152964924 Nonpathogen - GCN5-related N-acetyltransferase Krad_0956 1 COG0456 RimI, Acetyltransferases General function prediction only 152966453 Common - Alanine racemase Krad_2497 128 COG1609 PurR, Transcriptional regulators Transcription 152967342 Common - asparagine synthase (glutamine-hydrolyzing) Krad_3398 153 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 152967225 Common - protein kinase Krad_3281 75 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 152964884 Common - ABC transporter-related protein Krad_0916 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 152965803 Common - Membrane dipeptidase Krad_1837 101 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 152967398 Common - GTP-binding protein Obg/CgtA Krad_3455 249 COG0536 Obg, Predicted GTPase General function prediction only 152965439 Common - Methyltransferase type 11 Krad_1471 22 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152966970 Common - type II secretion system protein Krad_3026 152 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 152967734 Common - GCN5-related N-acetyltransferase Krad_3791 65 COG0456 RimI, Acetyltransferases General function prediction only 152966832 Common - major facilitator superfamily MFS_1 Krad_2887 22 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152964169 Common - Transcriptional regulator IclR Krad_0198 121 COG1414 IclR, Transcriptional regulator Transcription 152968224 Common - amidohydrolase Krad_4281 165 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 152964640 Common - ABC-2 type transporter Krad_0671 58 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 152964545 Common - lysyl-tRNA synthetase Krad_0576 249 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 152964242 Common - hypothetical protein Krad_0272 8 None None None 152965691 Nonpathogen - hypothetical protein Krad_1725 1 None None None 152966900 Common - inner-membrane translocator Krad_2956 134 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 152964399 Common - glycosyl transferase family 51 Krad_0429 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 152966763 Common - regulatory protein TetR Krad_2813 22 None None None 152966150 Common - hypothetical protein Krad_2187 4 None None None 152964651 Common - ribosomal protein S12 Krad_0682 246 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 152965188 Common - ferredoxin Krad_1220 105 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 152966866 Common - transketolase Krad_2922 221 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 152967151 Common - S-adenosyl-methyltransferase MraW Krad_3207 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 152964668 Common - ribosomal protein L24 Krad_0699 208 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 152964019 Common - Excalibur domain protein Krad_0048 24 None None None 152966288 Nonpathogen - hypothetical protein Krad_2327 1 None None None 152965529 Common - putative transporter Krad_1563 43 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 152964347 Common - glycosyl transferase group 1 Krad_0377 194 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152967357 Common - Acetyl xylan esterase Krad_3413 20 COG3458 COG3458, Acetyl esterase (deacetylase) Secondary metabolites biosynthesis, transport, and catabolism 152968067 Common - fructose-bisphosphate aldolase, class II Krad_4124 153 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 152966186 Common - Transcriptional regulator IclR Krad_2225 122 COG1414 IclR, Transcriptional regulator Transcription 152967561 Common - hypothetical protein Krad_3618 15 None None None 152964746 Common - monooxygenase FAD-binding Krad_0778 69 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 152967025 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Krad_3081 12 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 152966894 Common - diguanylate cyclase Krad_2950 175 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152965929 Common - ABC transporter-related protein Krad_1963 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 152968440 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_4501 161 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152964250 Common - hypothetical protein Krad_0280 7 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 152965255 Nonpathogen - amidohydrolase 2 Krad_1287 1 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 152964441 Common - uracil phosphoribosyltransferase Krad_0471 164 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 152964796 Common - short-chain dehydrogenase/reductase SDR Krad_0828 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152965761 Common - rhodopsin Krad_1795 11 COG5524 COG5524, Bacteriorhodopsin General function prediction only 152968062 Common - Adenylosuccinate synthase Krad_4119 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 152968111 Common - Male sterility domain Krad_4168 43 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 152965937 Nonpathogen - hypothetical protein Krad_1971 1 None None None 152967846 Common - alpha/beta hydrolase fold Krad_3903 37 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152966814 Nonpathogen - hypothetical protein Krad_2868 2 None None None 152967828 Common - ABC transporter-related protein Krad_3885 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 152964537 Common - glycosyl transferase group 1 Krad_0568 61 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152967493 Common - ABC transporter-related protein Krad_3550 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 152964202 Common - Stage II sporulation E family protein Krad_0232 57 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152966822 Common - hydrolase family protein Krad_2876 10 COG2267 PldB, Lysophospholipase Lipid metabolism 152965308 Common - Sucraseferredoxin family protein Krad_1340 19 COG4759 COG4759, Uncharacterized protein conserved in bacteria containing thioredoxin-like domain Posttranslational modification, protein turnover, chaperones 152964209 Common - periplasmic solute binding protein Krad_0239 137 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 152967738 Common - transcription factor WhiB Krad_3795 19 None None None 152966448 Common - regulator of ribonuclease activity A Krad_2492 101 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 152965089 Common - exodeoxyribonuclease VII, small subunit Krad_1121 28 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 152966307 Common - hypothetical protein Krad_2347 8 None None None 152966343 Nonpathogen - hypothetical protein Krad_2383 2 None None None 152967760 Common - integral membrane protein Krad_3817 7 None None None 152964177 Common - AzlC family protein Krad_0206 8 COG1296 AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) Amino acid transport and metabolism 152966428 Common - amine oxidase Krad_2472 46 COG1231 COG1231, Monoamine oxidase Amino acid transport and metabolism 152964140 Common - protein serine phosphatase with GAF(s) sensor(s) Krad_0169 68 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152966127 Common - oxidoreductase domain protein Krad_2163 173 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152964624 Common - RarD protein, DMT superfamily transporter Krad_0655 89 COG2962 RarD, Predicted permeases General function prediction only 152964464 Common - hypothetical protein Krad_0495 25 COG4898 COG4898, Uncharacterized protein conserved in bacteria Function unknown 152967404 Common - binding-protein-dependent transport systems inner membrane component Krad_3461 136 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152964330 Common - putative transcriptional regulator Krad_0360 15 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 152967588 Common - adenosine deaminase Krad_3645 95 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 152965896 Common - methyl-accepting chemotaxis sensory transducer Krad_1930 148 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152968161 Common - integral membrane sensor signal transduction histidine kinase Krad_4218 38 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152965244 Common - putative ATP/GTP-binding protein Krad_1276 14 None None None 152964290 Common - nuclear export factor GLE1 Krad_0320 22 COG4549 COG4549, Uncharacterized protein conserved in bacteria Function unknown 152964160 Nonpathogen - hypothetical protein Krad_0189 1 None None None 152965547 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Krad_1581 4 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152967638 Common - SAF domain protein Krad_3695 11 COG3745 CpaB, Flp pilus assembly protein CpaB Intracellular trafficking and secretion 152968125 Common - SNARE associated Golgi protein Krad_4182 120 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 152965817 Common - CheA signal transduction histidine kinase Krad_1851 148 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 152968177 Common - hypothetical protein Krad_4234 15 None None None 152967521 Common - Superoxide dismutase Krad_3578 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 152967009 Common - histidine triad (HIT) protein Krad_3065 116 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 152968341 Common - binding-protein-dependent transport systems inner membrane component Krad_4402 146 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152966658 Common - transcriptional regulator, DeoR family Krad_2706 114 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 152966986 Common - small GTP-binding protein Krad_3042 20 COG2229 COG2229, Predicted GTPase General function prediction only 152964245 Common - drug resistance transporter, EmrB/QacA subfamily Krad_0275 219 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152964344 Common - hypothetical protein Krad_0374 9 COG3759 COG3759, Predicted membrane protein Function unknown 152966839 Common - aromatic amino acid beta-eliminating lyase/threonine aldolase Krad_2895 13 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 152965296 Common - nitrite reductase (NAD(P)H), large subunit Krad_1328 209 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 152967143 Common - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Krad_3199 206 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 152967885 Nonpathogen - hypothetical protein Krad_3942 1 COG3393 COG3393, Predicted acetyltransferase General function prediction only 152966073 Common - two component transcriptional regulator, winged helix family Krad_2108 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152964104 Common - Glucose-6-phosphate 1-dehydrogenase Krad_0133 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 152964296 Common - diguanylate phosphodiesterase Krad_0326 162 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152966620 Common - DNA-binding protein Krad_2668 26 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 152967749 Nonpathogen - hypothetical protein Krad_3806 2 None None None 152967664 Common - oxidoreductase domain protein Krad_3721 41 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152964204 Common - NAD(P)H dehydrogenase (quinone) Krad_0234 76 COG1182 AcpD, Acyl carrier protein phosphodiesterase Lipid metabolism 152966759 Common - Naringenin-chalcone synthase Krad_2809 38 COG3424 BcsA, Predicted naringenin-chalcone synthase Secondary metabolites biosynthesis, transport, and catabolism 152966446 Common - transcriptional regulator, GntR family Krad_2490 118 COG1802 GntR, Transcriptional regulators Transcription 152966518 Nonpathogen - hypothetical protein Krad_2563 1 None None None 152967223 Common - 2-oxoglutarate dehydrogenase E2 component Krad_3279 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 152965398 Common - GCN5-related N-acetyltransferase Krad_1430 16 COG3393 COG3393, Predicted acetyltransferase General function prediction only 152964475 Common - transcriptional regulator, XRE family Krad_0506 14 COG1396 HipB, Predicted transcriptional regulators Transcription 152966261 Common - hypothetical protein Krad_2300 23 None None None 152965053 Common - hypothetical protein Krad_1085 12 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 152968276 Common - replicative DNA helicase Krad_4333 222 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 152964174 Common - Na+/H+ antiporter NhaA Krad_0203 106 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 152966669 Common - Alcohol dehydrogenase GroES domain protein Krad_2717 206 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 152967199 Common - hypothetical protein Krad_3255 5 COG0392 COG0392, Predicted integral membrane protein Function unknown 152968399 Common - Radical SAM domain protein Krad_4460 15 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 152964661 Common - ribosomal protein S19 Krad_0692 238 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 152967722 Common - SsrA-binding protein Krad_3779 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 152964311 Common - diguanylate cyclase/phosphodiesterase Krad_0341 174 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152966348 Nonpathogen - hypothetical protein Krad_2388 1 None None None 152967146 Common - phospho-N-acetylmuramoyl-pentapeptide-transferase Krad_3202 211 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 152964548 Common - ABC transporter-related protein Krad_0579 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 152966627 Common - Antibiotic biosynthesis monooxygenase Krad_2675 31 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 152965876 Common - Rieske (2Fe-2S) domain protein Krad_1910 50 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 152968215 Common - DNA-directed DNA polymerase Krad_4272 135 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 152966807 Common - hypothetical protein Krad_2861 14 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 152966291 Nonpathogen - peptidase domain protein Krad_2330 1 None None None 152967747 Nonpathogen - hypothetical protein Krad_3804 4 None None None 152966939 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Krad_2995 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 152968331 Nonpathogen - hypothetical protein Krad_4389 3 None None None 152968448 Common - single-stranded nucleic acid binding R3H domain protein Krad_4509 62 COG1847 Jag, Predicted RNA-binding protein General function prediction only 152966272 Common - regulatory protein LuxR Krad_2311 14 COG3899 COG3899, Predicted ATPase General function prediction only 152966847 Common - phosphoserine phosphatase SerB Krad_2903 146 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 152965643 Nonpathogen - carbon storage regulator, CsrA Krad_1677 1 COG1551 CsrA, Carbon storage regulator (could also regulate swarming and quorum sensing) Signal transduction mechanisms 152967200 Common - ErfK/YbiS/YcfS/YnhG family protein Krad_3256 19 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 152967153 Common - ATPase associated with various cellular activities AAA_3 Krad_3209 174 COG0714 COG0714, MoxR-like ATPases General function prediction only 152966218 Common - Antibiotic biosynthesis monooxygenase Krad_2257 5 COG1359 COG1359, Uncharacterized conserved protein Function unknown 152965905 Common - conserved hypothetical protein; putative signal peptide Krad_1939 47 COG2843 PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) Cell envelope biogenesis, outer membrane 152964626 Common - Electron transfer flavoprotein alpha/beta-subunit Krad_0657 152 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 152966615 Nonpathogen - hypothetical protein Krad_2663 1 None None None 152968027 Common - glutamate--cysteine ligase GCS2 Krad_4084 68 COG2170 COG2170, Uncharacterized conserved protein Function unknown 152966475 Common - glycoside hydrolase family 35 Krad_2520 6 COG1874 LacA, Beta-galactosidase Carbohydrate transport and metabolism 152966874 Common - Phosphoglycerate kinase Krad_2930 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 152964670 Common - ribosomal protein S14 Krad_0701 205 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 152965934 Nonpathogen - hypothetical protein Krad_1968 1 None None None 152968311 Nonpathogen - hypothetical protein Krad_4368 1 None None None 152967676 Common - glycoside hydrolase family 20 Krad_3733 31 COG3525 Chb, N-acetyl-beta-hexosaminidase Carbohydrate transport and metabolism 152967131 Common - DNA polymerase III, alpha subunit Krad_3187 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 152965133 Nonpathogen - hypothetical protein Krad_1165 1 COG3662 COG3662, Uncharacterized protein conserved in bacteria Function unknown 152967321 Common - 2-isopropylmalate synthase Krad_3377 211 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 152968150 Common - peptide chain release factor 3 Krad_4207 249 COG4108 PrfC, Peptide chain release factor RF-3 Translation, ribosomal structure and biogenesis 152965603 Common - Glutamate--putrescine ligase Krad_1637 223 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 152967375 Common - Xylose isomerase domain protein TIM barrel Krad_3432 7 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 152965668 Nonpathogen - hypothetical protein Krad_1702 1 None None None 152967118 Common - imidazole glycerol phosphate synthase, glutamine amidotransferase subunit Krad_3174 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 152964044 Common - Peptidoglycan glycosyltransferase Krad_0073 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 152967516 Common - extracellular solute-binding protein family 1 Krad_3573 79 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152966171 Common - putative transcriptional regulator, XRE family Krad_2210 16 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 152966655 Common - short-chain dehydrogenase/reductase SDR Krad_2703 109 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 152965783 Common - hypothetical protein Krad_1817 5 COG5406 COG5406, Nucleosome binding factor SPN, SPT16 subunit Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics 152965161 Common - protein of unknown function UPF0182 Krad_1193 48 COG1615 COG1615, Uncharacterized conserved protein Function unknown 152966716 Nonpathogen - hypothetical protein Krad_2765 1 None None None 152966960 Nonpathogen - hypothetical protein Krad_3016 1 None None None 152966232 Common - transposase IS3/IS911 family protein Krad_2271 59 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 152966239 Nonpathogen - hypothetical protein Krad_2278 1 None None None 152968195 Common - hypothetical protein Krad_4252 10 None None None 152965948 Common - diguanylate cyclase Krad_1982 188 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152965424 Common - short-chain dehydrogenase/reductase SDR Krad_1456 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152966102 Common - Methyltransferase type 11 Krad_2138 81 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152966951 Common - transcriptional regulator, XRE family Krad_3007 7 COG1396 HipB, Predicted transcriptional regulators Transcription 152965632 Common - flagellar biosynthetic protein FliP Krad_1666 128 COG1338 FliP, Flagellar biosynthesis pathway, component FliP Cell motility and secretion / Intracellular trafficking and secretion 152967064 Common - pseudouridine synthase Krad_3120 206 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 152967636 Nonpathogen - hypothetical protein Krad_3693 7 COG4632 EpsL, Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Carbohydrate transport and metabolism 152966548 Common - NAD-dependent epimerase/dehydratase Krad_2594 41 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152968020 Common - methyl-accepting chemotaxis sensory transducer Krad_4077 148 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152963984 Common - Non-specific protein-tyrosine kinase Krad_0012 121 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 152966577 Common - Serine-type D-Ala-D-Ala carboxypeptidase Krad_2625 135 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 152967277 Common - MMPL domain protein Krad_3333 16 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 152966662 Nonpathogen - hypothetical protein Krad_2710 1 None None None 152968007 Common - hypothetical protein Krad_4064 19 None None None 152967537 Common - conserved hypothetical protein 698 Krad_3594 90 COG2855 COG2855, Predicted membrane protein Function unknown 152966359 Nonpathogen - hypothetical protein Krad_2399 1 None None None 152967707 Common - glutamate racemase Krad_3764 189 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 152964836 Common - metallophosphoesterase Krad_0868 5 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 152966135 Common - binding-protein-dependent transport systems inner membrane component Krad_2172 216 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 152967482 Common - Alcohol dehydrogenase zinc-binding domain protein Krad_3539 151 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 152966958 Common - Shikimate kinase Krad_3014 200 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 152966829 Nonpathogen - GCN5-related N-acetyltransferase Krad_2884 4 COG1444 COG1444, Predicted P-loop ATPase fused to an acetyltransferase General function prediction only 152965456 Common - Formamidopyrimidine-DNA glycolase Krad_1488 125 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 152964304 Common - PAS/PAC sensor signal transduction histidine kinase Krad_0334 222 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 152967053 Common - isochorismatase hydrolase Krad_3109 50 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 152965168 Common - Glucose-6-phosphate 1-dehydrogenase Krad_1200 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 152967016 Common - ribonuclease BN Krad_3072 28 COG1295 Rbn, Predicted membrane protein Function unknown 152967692 Common - periplasmic solute binding protein Krad_3749 160 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 152967463 Common - Stage II sporulation E family protein Krad_3520 50 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152964159 Common - phosphate transporter Krad_0188 165 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 152964918 Common - diguanylate cyclase/phosphodiesterase Krad_0950 176 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152965801 Common - hypothetical protein Krad_1835 18 None None None 152964427 Common - response regulator receiver modulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase Krad_0457 246 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 152967949 Common - NAD-dependent epimerase/dehydratase Krad_4006 21 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152965271 Common - ABC transporter-related protein Krad_1303 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 152967034 Common - glycine dehydrogenase Krad_3090 172 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 152964773 Common - ribonucleoside-diphosphate reductase, alpha subunit Krad_0805 219 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 152965239 Common - H+transporting two-sector ATPase delta/epsilon subunit Krad_1271 145 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 152967186 Nonpathogen - hypothetical protein Krad_3242 2 None None None 152967648 Common - ABC transporter-related protein Krad_3705 249 COG4604 CeuD, ABC-type enterochelin transport system, ATPase component Inorganic ion transport and metabolism 152967928 Common - UDP-N-acetylglucosamine pyrophosphorylase related protein Krad_3985 17 COG1213 COG1213, Predicted sugar nucleotidyltransferases Cell envelope biogenesis, outer membrane 152964191 Common - GCN5-related N-acetyltransferase Krad_0220 42 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 152968113 Common - Transglycosylase domain protein Krad_4170 12 COG1388 LytE, FOG: LysM repeat Cell envelope biogenesis, outer membrane 152967310 Nonpathogen - UspA domain protein Krad_3366 1 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 152965685 Common - hypothetical protein Krad_1719 6 None None None 152966258 Nonpathogen - hypothetical protein Krad_2297 1 None None None 152966637 Common - bifunctional deaminase-reductase domain protein Krad_2685 60 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 152967740 Common - NAD-glutamate dehydrogenase Krad_3797 76 COG2902 COG2902, NAD-specific glutamate dehydrogenase Amino acid transport and metabolism 152966905 Common - Glutamate synthase (ferredoxin) Krad_2961 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 152967565 Common - peptidase S1 and S6 chymotrypsin/Hap Krad_3622 221 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 152966037 Common - CMP/dCMP deaminase zinc-binding Krad_2072 204 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 152967317 Common - undecaprenyl diphosphate synthase Krad_3373 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 152966492 Common - two component transcriptional regulator, LuxR family Krad_2537 154 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152966608 Nonpathogen - hypothetical protein Krad_2656 1 None None None 152966253 Nonpathogen - hypothetical protein Krad_2292 1 None None None 152965316 Common - protein of unknown function DUF214 Krad_1348 14 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 152965334 Common - thiamine-monophosphate kinase Krad_1366 168 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 152964675 Common - ribosomal protein L30 Krad_0706 134 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 152967508 Common - binding-protein-dependent transport systems inner membrane component Krad_3565 142 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152965612 Common - hypothetical protein Krad_1646 8 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 152965968 Nonpathogen - hypothetical protein Krad_2003 1 None None None 152968000 Common - Myo-inositol catabolism IolB domain protein Krad_4057 51 COG3718 IolB, Uncharacterized enzyme involved in inositol metabolism Carbohydrate transport and metabolism 152964821 Common - thiamine-phosphate pyrophosphorylase Krad_0853 156 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 152965014 Common - 4-diphosphocytidyl-2C-methyl-D-erythritol kinase Krad_1046 83 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 152965009 Common - hypothetical protein Krad_1041 8 None None None 152964341 Common - membrane protein-like protein Krad_0371 3 COG3463 COG3463, Predicted membrane protein Function unknown 152965402 Common - transcriptional regulator, XRE family Krad_1434 59 COG1396 HipB, Predicted transcriptional regulators Transcription 152964053 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Krad_0082 10 COG3871 COG3871, Uncharacterized stress protein (general stress protein 26) General function prediction only 152968083 Common - hypothetical protein Krad_4140 23 COG1846 MarR, Transcriptional regulators Transcription 152964029 Common - Asparaginase/glutaminase Krad_0058 133 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 152964415 Common - protein of unknown function DUF21 Krad_0445 216 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 152965344 Common - Ribonuclease III Krad_1376 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 152966194 Common - 3-oxoadipate enol-lactonase Krad_2233 103 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152966630 Nonpathogen - hypothetical protein Krad_2678 1 None None None 152965941 Common - Activator of Hsp90 ATPase 1 family protein Krad_1975 41 COG3832 COG3832, Uncharacterized conserved protein Function unknown 152968320 Nonpathogen - hypothetical protein Krad_4377 4 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 152965753 Common - ABC transporter-related protein Krad_1787 233 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 152964815 Nonpathogen - hypothetical protein Krad_0847 1 None None None 152967295 Common - protein of unknown function DUF451 Krad_3351 28 COG2822 COG2822, Predicted periplasmic lipoprotein involved in iron transport Inorganic ion transport and metabolism 152964222 Common - Methyltransferase type 12 Krad_0252 44 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 152964451 Nonpathogen - hypothetical protein Krad_0481 1 None None None 152966523 Common - GCN5-related N-acetyltransferase Krad_2568 24 COG3981 COG3981, Predicted acetyltransferase General function prediction only 152966969 Nonpathogen - secretory protein Krad_3025 2 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 152964094 Common - protein of unknown function DUF344 Krad_0123 127 COG2326 COG2326, Uncharacterized conserved protein Function unknown 152964020 Common - methyl-accepting chemotaxis sensory transducer Krad_0049 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152965997 Common - intracellular protease, PfpI family Krad_2032 161 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 152967333 Common - aminotransferase, class IV Krad_3389 53 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 152967631 Common - molybdenum cofactor synthesis domain Krad_3688 194 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 152965860 Common - glycerophosphoryl diester phosphodiesterase Krad_1894 146 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 152966996 Common - preprotein translocase, YajC subunit Krad_3052 8 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 152966802 Common - transcriptional regulator, MarR family Krad_2856 17 COG1846 MarR, Transcriptional regulators Transcription 152964631 Common - protein of unknown function DUF520 Krad_0662 107 COG1666 COG1666, Uncharacterized protein conserved in bacteria Function unknown 152966498 Common - binding-protein-dependent transport systems inner membrane component Krad_2543 166 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152966703 Common - protein of unknown function UPF0157 Krad_2751 14 COG2320 GrpB, Uncharacterized conserved protein Function unknown 152964744 Nonpathogen - stress-inducible protein Krad_0776 1 None None None 152968187 Common - diguanylate phosphodiesterase Krad_4244 52 COG3434 COG3434, Predicted signal transduction protein containing EAL and modified HD-GYP domains Signal transduction mechanisms 152965069 Common - LmbE family protein Krad_1101 26 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 152964995 Common - carbonic anhydrase Krad_1027 50 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 152967093 Common - hemolysin A Krad_3149 130 COG1189 COG1189, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 152964828 Common - beta-lactamase Krad_0860 128 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 152966406 Nonpathogen - hypothetical protein Krad_2447 1 None None None 152964154 Common - Activator of Hsp90 ATPase 1 family protein Krad_0183 9 COG3832 COG3832, Uncharacterized conserved protein Function unknown 152967829 Common - ABC-2 type transporter Krad_3886 83 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 152964386 Common - Endonuclease/exonuclease/phosphatase Krad_0416 11 COG3021 COG3021, Uncharacterized protein conserved in bacteria Function unknown 152965657 Common - phage integrase family protein Krad_1691 166 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 152964817 Common - hypothetical protein Krad_0849 4 None None None 152967769 Common - ABC transporter-related protein Krad_3826 237 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 152965865 Nonpathogen - hypothetical protein Krad_1899 1 None None None 152967956 Common - Lysine exporter protein (LYSE/YGGA) Krad_4013 68 COG1279 COG1279, Lysine efflux permease General function prediction only 152964725 Common - transcriptional regulator, TetR family Krad_0756 27 COG1309 AcrR, Transcriptional regulator Transcription 152966485 Common - glycoside hydrolase family 3 domain protein Krad_2530 118 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 152964409 Common - aliphatic sulfonates family ABC transporter, periplsmic ligand-binding protein Krad_0439 82 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 152964012 Common - monovalent cation/proton antiporter, MnhG/PhaG subunit Krad_0041 6 COG1320 MnhG, Multisubunit Na+/H+ antiporter, MnhG subunit Inorganic ion transport and metabolism 152965871 Common - 5 nucleotidase deoxy cytosolic type C Krad_1905 6 COG4502 COG4502, Uncharacterized protein conserved in bacteria Function unknown 152968390 Common - formiminoglutamate deiminase Krad_4451 140 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 152964061 Common - large conductance mechanosensitive channel protein Krad_0090 138 COG1970 MscL, Large-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 152968298 Common - transcriptional regulator, LysR family Krad_4355 183 COG0583 LysR, Transcriptional regulator Transcription 152967994 Common - Inositol 2-dehydrogenase Krad_4051 150 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152965037 Common - lipolytic protein G-D-S-L family Krad_1069 2 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 152968452 Common - ribosomal protein L34 Krad_4513 184 None None None 152966977 Common - Kojibiose phosphorylase Krad_3033 50 COG1554 ATH1, Trehalose and maltose hydrolases (possible phosphorylases) Carbohydrate transport and metabolism 152967207 Common - hypothetical protein Krad_3263 19 None None None 152967858 Common - two component transcriptional regulator, LuxR family Krad_3915 156 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152964734 Common - FAD linked oxidase domain protein Krad_0766 171 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 152966935 Common - DNA-directed RNA polymerase, omega subunit Krad_2991 20 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 152967244 Common - alpha amylase catalytic region Krad_3300 164 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 152968037 Nonpathogen - LrgA Krad_4094 1 COG1380 COG1380, Putative effector of murein hydrolase LrgA General function prediction only 152965555 Common - methionine-R-sulfoxide reductase Krad_1589 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 152965077 Common - hypothetical protein Krad_1109 7 None None None 152967125 Common - Histidinol dehydrogenase Krad_3181 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 152964198 Common - putative PAS/PAC sensor protein Krad_0227 72 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152964864 Common - two component transcriptional regulator, winged helix family Krad_0896 210 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152968263 Common - GCN5-related N-acetyltransferase Krad_4320 63 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 152964715 Common - short-chain dehydrogenase/reductase SDR Krad_0746 213 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152964356 Common - binding-protein-dependent transport systems inner membrane component Krad_0386 151 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152965266 Common - alpha-glucan phosphorylase Krad_1298 150 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 152967942 Common - succinyl-CoA synthetase, beta subunit Krad_3999 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 152964269 Common - Histidine--tRNA ligase Krad_0299 247 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152966201 Nonpathogen - RDD domain containing protein Krad_2240 1 COG1714 COG1714, Predicted membrane protein/domain Function unknown 152968030 Common - transcriptional regulator, TetR family Krad_4087 30 COG1309 AcrR, Transcriptional regulator Transcription 152964570 Common - protein of unknown function DUF892 Krad_0601 3 COG3685 COG3685, Uncharacterized protein conserved in bacteria Function unknown 152964424 Common - Methyltransferase type 11 Krad_0454 25 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152964756 Common - Domain of unknown function DUF1801 Krad_0788 12 None None None 152966612 Common - hypothetical protein Krad_2660 4 None None None 152968376 Nonpathogen - hypothetical protein Krad_4437 1 COG4907 COG4907, Predicted membrane protein Function unknown 152966642 Common - Epoxide hydrolase domain protein Krad_2690 37 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152968022 Common - transcriptional regulator, PucR family Krad_4079 9 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 152965301 Common - oxidoreductase domain protein Krad_1333 191 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152966507 Common - plasmid encoded RepA protein Krad_2552 19 None None None 152966178 Common - transcriptional regulator, TetR family Krad_2217 16 COG1309 AcrR, Transcriptional regulator Transcription 152965752 Common - hypothetical protein Krad_1786 6 None None None 152965961 Common - putative hydrolase protein Krad_1996 37 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152968360 Common - extracellular solute-binding protein family 3 Krad_4421 76 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 152964931 Common - binding-protein-dependent transport systems inner membrane component Krad_0963 171 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152967250 Common - hypothetical protein Krad_3306 24 None None None 152965741 Nonpathogen - hypothetical protein Krad_1775 1 None None None 152965673 Nonpathogen - hypothetical protein Krad_1707 1 COG4105 ComL, DNA uptake lipoprotein General function prediction only 152964318 Nonpathogen - hypothetical protein Krad_0348 1 None None None 152965544 Common - deoxyxylulose-5-phosphate synthase Krad_1578 207 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 152964766 Common - short-chain dehydrogenase/reductase SDR Krad_0798 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152965410 Common - protein of unknown function DUF448 Krad_1442 3 COG2740 COG2740, Predicted nucleic-acid-binding protein implicated in transcription termination Transcription 152967585 Common - major facilitator superfamily MFS_1 Krad_3642 71 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 152965591 Common - RNA polymerase, sigma 28 subunit, FliA/WhiG Krad_1625 140 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 152965105 Common - GCN5-related N-acetyltransferase Krad_1137 19 COG0456 RimI, Acetyltransferases General function prediction only 152966926 Common - PEP phosphonomutase Krad_2982 87 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 152965062 Common - von Willebrand factor type A Krad_1094 20 COG4867 COG4867, Uncharacterized protein with a von Willebrand factor type A (vWA) domain General function prediction only 152964089 Common - alpha-L-rhamnosidase Krad_0118 23 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 152967626 Common - polysaccharide pyruvyl transferase Krad_3683 18 COG5039 COG5039, Exopolysaccharide biosynthesis protein Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 152967528 Common - putative transcriptional regulator, GntR family Krad_3585 219 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 152965228 Common - Sua5/YciO/YrdC/YwlC family protein Krad_1260 238 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 152968362 Common - protein of unknown function DUF808 Krad_4423 60 COG2354 COG2354, Uncharacterized protein conserved in bacteria Function unknown 152964831 Common - transcriptional regulator, HxlR family Krad_0863 130 COG1733 COG1733, Predicted transcriptional regulators Transcription 152965723 Nonpathogen - hypothetical protein Krad_1757 1 None None None 152968306 Common - alpha/beta hydrolase fold Krad_4363 123 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152965149 Common - transcription factor WhiB Krad_1181 14 None None None 152967974 Common - biotin/lipoate A/B protein ligase Krad_4031 75 COG0095 LplA, Lipoate-protein ligase A Coenzyme metabolism 152967755 Nonpathogen - hypothetical protein Krad_3812 1 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 152965367 Common - hypothetical protein Krad_1399 60 COG1837 COG1837, Predicted RNA-binding protein (contains KH domain) General function prediction only 152968104 Common - diguanylate cyclase Krad_4161 175 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152966551 Nonpathogen - hypothetical protein Krad_2598 2 None None None 152966012 Common - ATPase associated with various cellular activities AAA_5 Krad_2047 49 COG0714 COG0714, MoxR-like ATPases General function prediction only 152967474 Common - MscS Mechanosensitive ion channel Krad_3531 225 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 152964943 Common - hypothetical protein Krad_0975 19 COG3828 COG3828, Uncharacterized protein conserved in bacteria Function unknown 152968369 Common - drug resistance transporter, Bcr/CflA subfamily Krad_4430 133 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152965002 Nonpathogen - hypothetical protein Krad_1034 1 None None None 152967161 Nonpathogen - hypothetical protein Krad_3217 1 None None None 152966086 Common - ABC transporter-related protein Krad_2122 249 COG3845 COG3845, ABC-type uncharacterized transport systems, ATPase components General function prediction only 152964700 Common - peptidase M22 glycoprotease Krad_0731 179 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 152964235 Common - glycoside hydrolase family 4 Krad_0265 50 COG1486 CelF, Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases Carbohydrate transport and metabolism 152967805 Common - binding-protein-dependent transport systems inner membrane component Krad_3862 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 152966909 Common - tryptophan synthase, beta subunit Krad_2965 224 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 152966164 Nonpathogen - hypothetical protein Krad_2201 4 None None None 152966924 Common - Ribulose-phosphate 3-epimerase Krad_2980 215 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 152966816 Common - Helix-turn-helix type 11 domain protein Krad_2870 17 COG2378 COG2378, Predicted transcriptional regulator Transcription 152966946 Common - carbamoyl-phosphate synthase, small subunit Krad_3002 232 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 152967232 Common - lipoic acid synthetase Krad_3288 190 COG0320 LipA, Lipoate synthase Coenzyme metabolism 152964950 Common - iron dependent repressor Krad_0982 44 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 152964106 Nonpathogen - hypothetical protein Krad_0135 3 None None None 152965190 Common - ABC transporter-related protein Krad_1222 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 152967435 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Krad_3492 16 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 152967788 Common - protein of unknown function ATP binding Krad_3845 28 COG2229 COG2229, Predicted GTPase General function prediction only 152965473 Common - hypothetical protein Krad_1505 13 None None None 152965458 Common - protein of unknown function DUF664 Krad_1490 13 None None None 152968420 Common - protein of unknown function DUF1469 Krad_4481 8 None None None 152966148 Nonpathogen - hypothetical protein Krad_2185 1 None None None 152965919 Nonpathogen - hypothetical protein Krad_1953 1 None None None 152966140 Common - acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase Krad_2177 172 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 152964411 Common - periplasmic binding protein Krad_0441 84 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 152964560 Common - binding-protein-dependent transport systems inner membrane component Krad_0591 140 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152963994 Common - Peptidylprolyl isomerase Krad_0022 175 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 152967698 Common - chaperonin Cpn10 Krad_3755 39 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 152967412 Common - extracellular solute-binding protein family 1 Krad_3469 59 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152966184 Common - alpha/beta hydrolase fold Krad_2223 55 COG2267 PldB, Lysophospholipase Lipid metabolism 152967556 Common - Glycerophosphodiester phosphodiesterase Krad_3613 145 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 152965739 Nonpathogen - hypothetical protein Krad_1773 1 None None None 152968206 Common - two component transcriptional regulator, LuxR family Krad_4263 219 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152966790 Nonpathogen - hypothetical protein Krad_2842 1 None None None 152964036 Common - signal transduction histidine kinase regulating citrate/malate metabolism Krad_0065 43 COG3290 CitA, Signal transduction histidine kinase regulating citrate/malate metabolism Signal transduction mechanisms 152964145 Common - aminotransferase class V Krad_0174 89 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 152965370 Common - ribosomal protein L19 Krad_1402 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 152965018 Common - transcriptional regulator, TetR family Krad_1050 98 COG1309 AcrR, Transcriptional regulator Transcription 152967725 Common - peptide chain release factor 2 Krad_3782 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 152967419 Common - O-succinylhomoserine sulfhydrylase Krad_3476 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 152965399 Common - major facilitator superfamily MFS_1 Krad_1431 18 None None None 152964611 Common - putative GAF sensor protein Krad_0642 67 COG2203 FhlA, FOG: GAF domain Signal transduction mechanisms 152966753 Nonpathogen - hypothetical protein Krad_2803 1 None None None 152964013 Nonpathogen - multiple resistance and pH regulation protein F Krad_0042 1 COG2212 MnhF, Multisubunit Na+/H+ antiporter, MnhF subunit Inorganic ion transport and metabolism 152965007 Common - Alcohol dehydrogenase zinc-binding domain protein Krad_1039 147 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 152967308 Common - putative deoxyguanosinetriphosphate triphosphohydrolase Krad_3364 159 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 152964677 Common - preprotein translocase, SecY subunit Krad_0708 226 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 152967108 Common - phenylalanyl-tRNA synthetase, alpha subunit Krad_3164 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 152967495 Common - NLP/P60 protein Krad_3552 136 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 152965462 Common - Antibiotic biosynthesis monooxygenase Krad_1494 3 COG1359 COG1359, Uncharacterized conserved protein Function unknown 152964748 Common - transcriptional regulator, TetR family Krad_0780 6 COG1309 AcrR, Transcriptional regulator Transcription 152965377 Common - DNA protecting protein DprA Krad_1409 201 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 152964403 Common - putative PAS/PAC sensor protein Krad_0433 34 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152966964 Common - peptidase A24A domain protein Krad_3020 117 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 152964509 Common - dihydropteroate synthase Krad_0540 216 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 152966994 Common - protein-export membrane protein SecF Krad_3050 217 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 152967751 Common - diguanylate cyclase/phosphodiesterase Krad_3808 170 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152965696 Nonpathogen - hypothetical protein Krad_1730 1 None None None 152967097 Common - tyrosyl-tRNA synthetase Krad_3153 216 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152968129 Common - orotate phosphoribosyltransferase Krad_4186 72 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 152965596 Nonpathogen - hypothetical protein Krad_1630 1 None None None 152964539 Common - NAD-dependent epimerase/dehydratase Krad_0570 218 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152966999 Common - Carboxymethylenebutenolidase Krad_3055 116 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 152967090 Common - Thiamin pyrophosphokinase catalytic region Krad_3146 19 COG4825 COG4825, Uncharacterized membrane-anchored protein conserved in bacteria Function unknown 152966788 Nonpathogen - hypothetical protein Krad_2840 1 None None None 152964115 Common - protein of unknown function DUF1275 Krad_0144 6 COG3619 COG3619, Predicted membrane protein Function unknown 152966555 Nonpathogen - hypothetical protein Krad_2602 1 None None None 152966139 Common - transposase and inactivated derivatives-like protein Krad_2176 11 None None None 152965138 Common - Methylenetetrahydrofolate reductase (NAD(P)H) Krad_1170 139 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 152965201 Nonpathogen - hypothetical protein Krad_1233 1 None None None 152967985 Common - hypothetical protein Krad_4042 18 None None None 152965021 Common - ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5 Krad_1053 186 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 152965197 Common - integral membrane sensor signal transduction histidine kinase Krad_1229 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152967864 Nonpathogen - hypothetical protein Krad_3921 2 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 152964948 Nonpathogen - hypothetical protein Krad_0980 1 None None None 152966463 Nonpathogen - hypothetical protein Krad_2508 1 None None None 152964813 Nonpathogen - hypothetical protein Krad_0845 1 None None None 152965131 Common - PHP domain protein Krad_1163 126 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 152968313 Nonpathogen - hypothetical protein Krad_4370 1 None None None 152965627 Common - OmpA/MotB domain protein Krad_1661 140 COG1360 MotB, Flagellar motor protein Cell motility and secretion 152966228 Nonpathogen - hypothetical protein Krad_2267 1 None None None 152965332 Nonpathogen - hypothetical protein Krad_1364 3 None None None 152967874 Common - Alcohol dehydrogenase zinc-binding domain protein Krad_3931 150 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 152964516 Common - membrane-flanked domain Krad_0547 26 COG3402 COG3402, Uncharacterized conserved protein Function unknown 152968175 Common - GrpE protein Krad_4232 201 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 152964618 Common - Polyprenyl synthetase Krad_0649 241 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 152966781 Nonpathogen - hypothetical protein Krad_2833 2 None None None 152968017 Common - phenazine biosynthesis protein PhzF family Krad_4074 101 COG0384 COG0384, Predicted epimerase, PhzC/PhzF homolog General function prediction only 152966694 Common - transcriptional regulator, TetR family Krad_2742 87 COG1309 AcrR, Transcriptional regulator Transcription 152968069 Common - luciferase family protein Krad_4126 57 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152964458 Common - acyltransferase 3 Krad_0488 3 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 152967388 Common - Shikimate dehydrogenase substrate binding domain protein Krad_3445 49 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 152968416 Common - response regulator receiver and ANTAR domain protein Krad_4477 18 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 152964320 Common - diguanylate cyclase Krad_0350 165 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152964350 Nonpathogen - hypothetical protein Krad_0380 1 COG4982 COG4982, 3-oxoacyl- acyl-carrier protein 152968072 Nonpathogen - hypothetical protein Krad_4129 1 None None None 152964895 Common - ABC transporter-related protein Krad_0927 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 152968019 Common - solute-binding protein Krad_4076 60 COG4213 XylF, ABC-type xylose transport system, periplasmic component Carbohydrate transport and metabolism 152965028 Nonpathogen - hypothetical protein Krad_1060 13 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 152966113 Nonpathogen - hypothetical protein Krad_2149 1 None None None 152965352 Common - L-lactate dehydrogenase (cytochrome) Krad_1384 111 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 152966672 Common - drug:proton antiporter Krad_2720 148 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 152967658 Common - hypothetical protein Krad_3715 23 COG2339 COG2339, Predicted membrane protein Function unknown 152968140 Common - GntR domain protein Krad_4197 128 COG2186 FadR, Transcriptional regulators Transcription 152967718 Common - NADH:flavin oxidoreductase/NADH oxidase Krad_3775 177 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 152964957 Nonpathogen - hypothetical protein Krad_0989 1 None None None 152966756 Common - major facilitator superfamily MFS_1 Krad_2806 78 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 152965027 Nonpathogen - membrane protein-like protein Krad_1059 8 COG4906 COG4906, Predicted membrane protein Function unknown 152964118 Common - binding-protein-dependent transport systems inner membrane component Krad_0147 218 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 152968218 Common - copper resistance D domain protein Krad_4275 23 COG3336 COG3336, Predicted membrane protein Function unknown 152964532 Nonpathogen - lipopolysaccharide biosynthesis protein Krad_0563 1 COG3944 COG3944, Capsular polysaccharide biosynthesis protein Cell envelope biogenesis, outer membrane 152965048 Common - protein of unknown function DUF1112 Krad_1080 31 COG4760 COG4760, Predicted membrane protein Function unknown 152965298 Common - major facilitator superfamily MFS_1 Krad_1330 65 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 152964504 Common - LamB/YcsF family protein Krad_0535 100 COG1540 COG1540, Uncharacterized proteins, homologs of lactam utilization protein B General function prediction only 152966512 Common - protein of unknown function DUF1016 Krad_2557 49 COG4804 COG4804, Uncharacterized conserved protein Function unknown 152964754 Common - short-chain dehydrogenase/reductase SDR Krad_0786 236 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 152964636 Common - UDP-N-acetylmuramate dehydrogenase Krad_0667 196 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 152965359 Nonpathogen - hypothetical protein Krad_1391 1 None None None 152967535 Common - Protein of unknown function DUF1810 Krad_3592 28 COG5579 COG5579, Uncharacterized conserved protein Function unknown 152964780 Nonpathogen - hypothetical protein Krad_0812 3 None None None 152968131 Common - extracellular solute-binding protein family 1 Krad_4188 33 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152968064 Common - hypothetical protein Krad_4121 14 None None None 152965532 Common - aconitate hydratase 1 Krad_1566 217 COG1048 AcnA, Aconitase A Energy production and conversion 152967604 Nonpathogen - hypothetical protein Krad_3661 2 None None None 152967381 Common - putative transcriptional regulator, XRE family Krad_3438 41 COG1396 HipB, Predicted transcriptional regulators Transcription 152967329 Common - CBS domain containing protein Krad_3385 215 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 152968332 Common - DEAD/DEAH box helicase domain protein Krad_4391 196 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 152967770 Common - beta-lactamase Krad_3827 105 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 152967884 Common - 60 kDa inner membrane insertion protein Krad_3941 15 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 152965764 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Krad_1798 130 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 152966590 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Krad_2638 23 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 152964497 Common - hypothetical protein Krad_0528 26 COG5282 COG5282, Uncharacterized conserved protein Function unknown 152967779 Nonpathogen - hypothetical protein Krad_3836 1 None None None 152966250 Common - NADP oxidoreductase coenzyme F420-dependent Krad_2289 37 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 152967701 Nonpathogen - hypothetical protein Krad_3758 5 COG5343 COG5343, Uncharacterized protein conserved in bacteria Function unknown 152964442 Nonpathogen - hypothetical protein Krad_0472 1 None None None 152964211 Common - hypothetical protein Krad_0241 17 None None None 152965679 Nonpathogen - hypothetical protein Krad_1713 1 None None None 152966471 Nonpathogen - hypothetical protein Krad_2516 1 None None None 152967919 Nonpathogen - hypothetical protein Krad_3976 4 None None None 152964572 Common - DNA repair protein RadA Krad_0603 203 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 152964240 Common - hypothetical protein Krad_0270 9 None None None 152968355 Nonpathogen - NERD domain protein Krad_4416 5 None None None 152964192 Common - putative transcriptional regulator, AsnC family Krad_0221 157 COG1522 Lrp, Transcriptional regulators Transcription 152967048 Common - ATP-dependent helicase HrpA Krad_3104 131 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 152966849 Common - hypothetical protein Krad_2905 9 None None None 152964492 Common - diguanylate cyclase/phosphodiesterase Krad_0523 177 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152964076 Common - hypothetical protein Krad_0105 17 None None None 152964041 Nonpathogen - hypothetical protein Krad_0070 1 None None None 152965925 Common - Helix-turn-helix type 11 domain protein Krad_1959 81 COG2378 COG2378, Predicted transcriptional regulator Transcription 152965886 Common - Xylose isomerase domain protein TIM barrel Krad_1920 7 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 152966613 Nonpathogen - hypothetical protein Krad_2661 1 None None None 152966328 Nonpathogen - hypothetical protein Krad_2368 1 None None None 152964804 Common - Alcohol dehydrogenase zinc-binding domain protein Krad_0836 57 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 152964377 Common - hypothetical protein Krad_0407 4 None None None 152964393 Nonpathogen - hypothetical protein Krad_0423 1 None None None 152965672 Nonpathogen - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Krad_1706 1 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 152966860 Common - FeS assembly protein SufD Krad_2916 176 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 152964692 Common - pantothenate kinase Krad_0723 79 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 152964935 Common - SCP-like extracellular protein Krad_0967 14 COG5479 COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis Cell envelope biogenesis, outer membrane 152966599 Common - transcriptional regulator, TetR family Krad_2647 34 COG1309 AcrR, Transcriptional regulator Transcription 152965939 Nonpathogen - hypothetical protein Krad_1973 1 None None None 152968127 Common - Methyltransferase type 11 Krad_4184 34 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152965774 Common - ATPase associated with various cellular activities AAA_3 Krad_1808 22 COG0714 COG0714, MoxR-like ATPases General function prediction only 152967479 Common - helix-turn-helix domain protein Krad_3536 32 COG3800 COG3800, Predicted transcriptional regulator General function prediction only 152967340 Common - Formamidopyrimidine-DNA glycolase Krad_3396 38 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 152964882 Common - NAD-dependent epimerase/dehydratase Krad_0914 40 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152967502 Common - nicotinate-nucleotide pyrophosphorylase Krad_3559 201 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 152964798 Common - protein of unknown function UPF0126 Krad_0830 119 COG2860 COG2860, Predicted membrane protein Function unknown 152964760 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Krad_0792 23 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 152968442 Common - thioredoxin reductase Krad_4503 247 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 152965166 Common - two component transcriptional regulator, LuxR family Krad_1198 218 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152964595 Common - glutamate-1-semialdehyde-2,1-aminomutase Krad_0626 236 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 152967767 Common - protein of unknown function DUF72 Krad_3824 104 COG1801 COG1801, Uncharacterized conserved protein Function unknown 152966286 Common - regulatory protein LuxR Krad_2325 43 COG3899 COG3899, Predicted ATPase General function prediction only 152967848 Common - phosphoribosylaminoimidazole carboxylase, ATPase subunit Krad_3905 186 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 152966988 Common - pentapeptide repeat protein Krad_3044 10 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 152966876 Common - protein of unknown function DUF199 Krad_2932 39 COG1481 COG1481, Uncharacterized protein conserved in bacteria Function unknown 152964064 Nonpathogen - glycerone kinase Krad_0093 1 None None None 152967672 Common - ROK family protein Krad_3729 118 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 152967840 Common - glycosyl transferase family 2 Krad_3897 62 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152967594 Common - NLPA lipoprotein Krad_3651 100 COG1464 NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen Inorganic ion transport and metabolism 152963974 Common - DNA polymerase III, beta subunit Krad_0002 212 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 152968163 Common - Ribonuclease Z Krad_4220 88 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 152964179 Common - hypothetical protein Krad_0208 9 None None None 152965849 Common - Sec-independent protein translocase, TatC subunit Krad_1883 203 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 152965078 Common - ribosomal protein S4 Krad_1110 244 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 152966341 Nonpathogen - hypothetical protein Krad_2381 1 None None None 152965446 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Krad_1478 118 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 152964163 Common - Camphor resistance CrcB protein Krad_0192 3 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 152964642 Common - aminotransferase class I and II Krad_0673 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 152965183 Common - transcriptional regulator, AraC family Krad_1215 119 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 152965589 Common - hypothetical protein Krad_1623 4 None None None 152967352 Common - hypothetical protein Krad_3408 3 COG3296 COG3296, Uncharacterized protein conserved in bacteria Function unknown 152967075 Nonpathogen - hypothetical protein Krad_3131 1 None None None 152965263 Common - 1,4-alpha-glucan branching enzyme Krad_1295 55 COG3281 Ble, Uncharacterized protein, probably involved in trehalose biosynthesis Carbohydrate transport and metabolism 152964289 Nonpathogen - hypothetical protein Krad_0319 1 None None None 152965908 Common - transcriptional regulator, PadR-like family Krad_1942 34 COG1695 COG1695, Predicted transcriptional regulators Transcription 152965170 Nonpathogen - hypothetical protein Krad_1202 1 COG4095 COG4095, Uncharacterized conserved protein Function unknown 152965568 Common - Formate dehydrogenase Krad_1602 171 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 152966421 Nonpathogen - hypothetical protein Krad_2465 1 None None None 152967523 Common - putative cold-shock DNA-binding domain protein Krad_3580 170 COG1278 CspC, Cold shock proteins Transcription 152966649 Common - NUDIX hydrolase Krad_2697 127 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 152964280 Common - integral membrane sensor signal transduction histidine kinase Krad_0310 87 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152964622 Common - ATP dependent DNA ligase Krad_0653 105 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 152965655 Nonpathogen - hypothetical protein Krad_1689 1 None None None 152966629 Common - death-on-curing family protein Krad_2677 45 COG3654 Doc, Prophage maintenance system killer protein General function prediction only 152967195 Common - cytochrome c class I Krad_3251 35 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 152967247 Nonpathogen - hypothetical protein Krad_3303 1 None None None 152967912 Common - tryptophanyl-tRNA synthetase Krad_3969 229 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152965085 Nonpathogen - Protein involved in cellulose biosynthesis (CelD)-like protein Krad_1117 3 COG5653 COG5653, Protein involved in cellulose biosynthesis (CelD) Cell envelope biogenesis, outer membrane 152964332 Nonpathogen - glycosyl transferase family 39 Krad_0362 1 COG1928 PMT1, Dolichyl-phosphate-mannose--protein O-mannosyl transferase Posttranslational modification, protein turnover, chaperones 152964769 Common - protein of unknown function DUF718 Krad_0801 26 COG3254 COG3254, Uncharacterized conserved protein Function unknown 152968239 Common - adenylosuccinate lyase Krad_4296 232 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 152964462 Common - transcriptional regulator, TetR family Krad_0493 92 COG1309 AcrR, Transcriptional regulator Transcription 152966880 Common - UDP-N-acetylglucosamine 2-epimerase Krad_2936 149 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 152966432 Common - protein of unknown function DUF470 Krad_2476 49 COG2898 COG2898, Uncharacterized conserved protein Function unknown 152965177 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Krad_1209 228 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 152966892 Common - RNA binding S1 domain protein Krad_2948 216 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 152965102 Common - LmbE family protein Krad_1134 29 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 152967586 Common - transcriptional regulator, GntR family Krad_3643 130 COG1802 GntR, Transcriptional regulators Transcription 152965806 Common - protein of unknown function DUF124 Krad_1840 32 COG2013 COG2013, Uncharacterized conserved protein Function unknown 152963976 Common - DNA replication and repair protein RecF Krad_0004 161 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 152968181 Common - hypothetical protein Krad_4238 4 None None None 152965325 Common - Transcriptional regulator IclR Krad_1357 72 COG1414 IclR, Transcriptional regulator Transcription 152967396 Nonpathogen - hypothetical protein Krad_3453 3 None None None 152964638 Nonpathogen - hypothetical protein Krad_0669 1 None None None 152968164 Common - diguanylate cyclase with PAS/PAC sensor Krad_4221 174 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152964324 Nonpathogen - PilT protein domain protein Krad_0354 1 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 152964724 Common - MMPL domain protein Krad_0755 20 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 152967459 Common - Endopeptidase Clp Krad_3516 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 152964979 Common - putative glutamine amidotransferase Krad_1011 165 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 152966677 Common - transcriptional regulator, AraC family Krad_2725 108 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 152964184 Nonpathogen - hypothetical protein Krad_0213 2 None None None 152966020 Common - glycosyl transferase group 1 Krad_2055 74 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152966545 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Krad_2591 45 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 152968294 Common - Adenosine deaminase Krad_4351 58 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 152967934 Common - isopentenyl-diphosphate delta-isomerase, type 1 Krad_3991 51 COG1443 Idi, Isopentenyldiphosphate isomerase Lipid metabolism 152964226 Nonpathogen - hypothetical protein Krad_0256 1 None None None 152967560 Common - protein of unknown function DUF839 Krad_3617 72 COG3211 PhoX, Predicted phosphatase General function prediction only 152965058 Common - two component transcriptional regulator, LuxR family Krad_1090 32 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152966805 Common - NAD(P)H dehydrogenase (quinone) Krad_2859 85 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 152965984 Nonpathogen - hypothetical protein Krad_2019 1 COG4907 COG4907, Predicted membrane protein Function unknown 152967613 Common - glycosyl transferase family 2 Krad_3670 94 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152965573 Common - selenide, water dikinase Krad_1607 102 COG0709 SelD, Selenophosphate synthase Amino acid transport and metabolism 152964975 Common - MIP family channel protein Krad_1007 135 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 152964452 Common - DEAD/DEAH box helicase domain protein Krad_0482 74 COG1205 COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster General function prediction only 152965978 Common - small multidrug resistance protein Krad_2013 140 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 152967452 Common - Myo-inositol-1-phosphate synthase Krad_3509 58 COG1260 INO1, Myo-inositol-1-phosphate synthase Lipid metabolism 152967409 Common - glycoside hydrolase family 2 TIM barrel Krad_3466 72 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 152964877 Common - beta-lactamase domain protein Krad_0909 210 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 152967367 Nonpathogen - hypothetical protein Krad_3424 1 None None None 152966585 Nonpathogen - hypothetical protein Krad_2633 1 None None None 152965574 Common - L-seryl-tRNA(Sec) selenium transferase Krad_1608 64 COG1921 SelA, Selenocysteine synthase [seryl-tRNASer selenium transferase] Amino acid transport and metabolism 152966830 Common - phenazine biosynthesis protein PhzF family Krad_2885 89 COG0384 COG0384, Predicted epimerase, PhzC/PhzF homolog General function prediction only 152967865 Common - ABC-2 type transporter Krad_3922 88 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 152968119 Common - NifC-like ABC-type porter Krad_4176 206 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 152964376 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_0406 139 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152967085 Common - CTP synthase Krad_3141 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 152965840 Common - 20S proteasome A and B subunits Krad_1874 14 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 152964986 Common - potassium-transporting ATPase, C subunit Krad_1018 93 COG2156 KdpC, K+-transporting ATPase, c chain Inorganic ion transport and metabolism 152965944 Common - integral membrane protein Krad_1978 3 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 152966323 Nonpathogen - hypothetical protein Krad_2363 1 None None None 152965833 Common - NUDIX hydrolase Krad_1867 36 COG1443 Idi, Isopentenyldiphosphate isomerase Lipid metabolism 152967140 Common - cell division protein FtsZ Krad_3196 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 152964266 Common - binding-protein-dependent transport systems inner membrane component Krad_0296 141 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152967682 Common - regulatory protein LacI Krad_3739 120 COG1609 PurR, Transcriptional regulators Transcription 152965950 Common - putative TfxG-like immunity protein against TfxA-like peptides Krad_1984 12 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 152964597 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Krad_0628 118 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 152966887 Common - dephospho-CoA kinase Krad_2943 106 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 152965434 Common - guanosine pentaphosphate synthetase I/polyribonucleotide nucleotidyltransferase Krad_1466 236 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 152967051 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_3107 114 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152965432 Common - riboflavin biosynthesis protein RibF Krad_1464 209 COG0196 RibF, FAD synthase Coenzyme metabolism 152968222 Common - ferric uptake regulator, Fur family Krad_4279 43 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 152967401 Common - ribonuclease, Rne/Rng family Krad_3458 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 152967610 Common - glycosyl transferase family 39 Krad_3667 34 COG1928 PMT1, Dolichyl-phosphate-mannose--protein O-mannosyl transferase Posttranslational modification, protein turnover, chaperones 152967923 Common - Methenyltetrahydrofolate cyclohydrolase Krad_3980 223 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 152966868 Common - glucose-6-phosphate 1-dehydrogenase Krad_2924 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 152965448 Common - beta-lactamase domain protein Krad_1480 155 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 152968245 Common - phospholipase D/Transphosphatidylase Krad_4302 151 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 152967777 Common - RDD domain containing protein Krad_3834 12 COG1714 COG1714, Predicted membrane protein/domain Function unknown 152964686 Common - tRNA-pseudouridine synthase I Krad_0717 180 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 152965114 Nonpathogen - hypothetical protein Krad_1146 2 None None None 152968250 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Krad_4307 187 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152966082 Common - GCN5-related N-acetyltransferase Krad_2117 51 COG0456 RimI, Acetyltransferases General function prediction only 152967736 Common - RNA polymerase, sigma 28 subunit, FliA/WhiG family Krad_3793 212 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 152964653 Common - translation elongation factor G Krad_0684 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 152966296 Nonpathogen - hypothetical protein Krad_2336 1 None None None 152968188 Common - Ankyrin Krad_4245 36 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 152965480 Common - NAD-dependent epimerase/dehydratase Krad_1512 16 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152967003 Common - NUDIX hydrolase Krad_3059 12 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 152964136 Common - ribose-phosphate pyrophosphokinase Krad_0165 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 152964970 Common - methyl-accepting chemotaxis sensory transducer Krad_1002 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152965011 Common - hydrolase, TatD family Krad_1043 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 152966857 Nonpathogen - cobalt transport protein Krad_2913 1 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 152965489 Common - phage SPO1 DNA polymerase-related protein Krad_1521 147 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 152966663 Common - helix-turn-helix- domain containing protein AraC type Krad_2711 73 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 152966714 Nonpathogen - hypothetical protein Krad_2763 1 None None None 152966336 Nonpathogen - hypothetical protein Krad_2376 1 None None None 152966078 Common - PilT protein-like protein Krad_2113 5 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 152967603 Common - acyltransferase 3 Krad_3660 46 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 152967896 Common - Succinate dehydrogenase hydrophobic anchor subunit-like protein Krad_3953 13 COG2142 SdhD, Succinate dehydrogenase, hydrophobic anchor subunit Energy production and conversion 152966973 Common - Shikimate dehydrogenase substrate binding domain protein Krad_3029 165 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 152965464 Common - polar amino acid ABC transporter, inner membrane subunit Krad_1496 172 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 152965520 Nonpathogen - hypothetical protein Krad_1554 1 None None None 152965634 Common - flagellar biosynthetic protein FliR Krad_1668 110 COG1684 FliR, Flagellar biosynthesis pathway, component FliR Cell motility and secretion / Intracellular trafficking and secretion 152964171 Common - short-chain dehydrogenase/reductase SDR Krad_0200 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152966415 Common - response regulator receiver and ANTAR domain protein Krad_2459 14 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 152965426 Common - Monosaccharide-transporting ATPase Krad_1458 147 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 152964206 Nonpathogen - hypothetical protein Krad_0236 1 None None None 152968094 Common - polar amino acid ABC transporter, inner membrane subunit Krad_4151 174 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 152967875 Common - GTPase EngC Krad_3932 156 COG1162 COG1162, Predicted GTPases General function prediction only 152964384 Common - regulatory protein LacI Krad_0414 122 COG1609 PurR, Transcriptional regulators Transcription 152966742 Common - hypothetical protein Krad_2792 4 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 152964870 Common - hypothetical protein Krad_0902 41 COG3665 COG3665, Uncharacterized conserved protein Function unknown 152964122 Common - DNA-(apurinic or apyrimidinic site) lyase Krad_0151 147 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 152966531 Common - hypothetical protein Krad_2576 3 None None None 152968005 Common - protein of unknown function DUF336 Krad_4062 20 COG4702 COG4702, Uncharacterized conserved protein Function unknown 152964361 Common - Xylose isomerase domain protein TIM barrel Krad_0391 63 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 152967795 Common - F420-dependent oxidoreductase, putative Krad_3852 16 COG1478 COG1478, Uncharacterized conserved protein Function unknown 152967312 Common - Benzoate membrane transport protein Krad_3368 23 COG3135 BenE, Uncharacterized protein involved in benzoate metabolism Secondary metabolites biosynthesis, transport, and catabolism 152964400 Nonpathogen - hypothetical protein Krad_0430 5 None None None 152965716 Nonpathogen - hypothetical protein Krad_1750 1 None None None 152966795 Common - transposase IS3/IS911 family protein Krad_2848 59 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 152966827 Nonpathogen - hypothetical protein Krad_2881 1 None None None 152968172 Common - putative secreted protein Krad_4229 31 COG2706 COG2706, 3-carboxymuconate cyclase Carbohydrate transport and metabolism 152967066 Common - chromosome segregation and condensation protein ScpA Krad_3122 105 COG1354 COG1354, Uncharacterized conserved protein Function unknown 152966855 Nonpathogen - BioY protein Krad_2911 1 COG1268 BioY, Uncharacterized conserved protein General function prediction only 152967023 Common - Rhodanese domain protein Krad_3079 145 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152966381 Nonpathogen - hypothetical protein Krad_2421 1 None None None 152966956 Nonpathogen - hypothetical protein Krad_3012 1 None None None 152967745 Common - hypothetical protein Krad_3802 8 COG1261 FlgA, Flagellar basal body P-ring biosynthesis protein Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 152964364 Nonpathogen - hypothetical protein Krad_0394 1 None None None 152965306 Nonpathogen - hypothetical protein Krad_1338 1 None None None 152966400 Common - diguanylate phosphodiesterase Krad_2441 150 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152967790 Common - Roadblock/LC7 family protein Krad_3847 12 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 152967969 Common - MaoC domain protein dehydratase Krad_4026 25 COG2030 MaoC, Acyl dehydratase Lipid metabolism 152966041 Common - protein of unknown function DUF182 Krad_2076 116 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 152965283 Common - DNA ligase, NAD-dependent Krad_1315 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 152965815 Common - Protein-glutamate O-methyltransferase Krad_1849 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 152966398 Common - diguanylate cyclase Krad_2439 180 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152964157 Nonpathogen - hypothetical protein Krad_0186 4 None None None 152966007 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Krad_2042 24 None None None 152967160 Nonpathogen - hypothetical protein Krad_3216 1 None None None 152967438 Nonpathogen - hypothetical protein Krad_3495 2 None None None 152967469 Common - transcription factor WhiB Krad_3526 18 None None None 152964701 Common - major facilitator superfamily MFS_1 Krad_0732 78 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 152966430 Nonpathogen - hypothetical protein Krad_2474 1 None None None 152967167 Common - protein of unknown function DUF422 Krad_3223 7 COG2324 COG2324, Predicted membrane protein Function unknown 152967262 Common - phage shock protein C, PspC Krad_3318 25 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 152964055 Common - Endoribonuclease L-PSP Krad_0084 10 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 152964771 Common - glutaredoxin-like protein NrdH Krad_0803 28 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 152965112 Common - conserved hypothetical protein 730 Krad_1144 123 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 152967720 Common - hypothetical protein Krad_3777 4 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 152965505 Common - Phosphotransferase system, phosphocarrier protein HPr Krad_1539 17 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 152964439 Common - CMP/dCMP deaminase zinc-binding Krad_0469 191 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 152967319 Common - DNA repair protein RecO Krad_3375 47 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 152966032 Common - permease for cytosine/purines uracil thiamine allantoin Krad_2067 19 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 152966263 Nonpathogen - hypothetical protein Krad_2302 1 None None None 152966056 Common - binding-protein-dependent transport systems inner membrane component Krad_2091 196 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152964899 Common - putative nitrilotriacetate monoxygenase, component A Krad_0931 61 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152964855 Nonpathogen - hypothetical protein Krad_0887 1 None None None 152965409 Common - NusA antitermination factor Krad_1441 225 COG0195 NusA, Transcription elongation factor Transcription 152967188 Nonpathogen - hypothetical protein Krad_3244 1 None None None 152965963 Common - two component transcriptional regulator, LuxR family Krad_1998 212 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152964326 Common - diguanylate cyclase/phosphodiesterase Krad_0356 159 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152967032 Common - protein of unknown function DUF107 Krad_3088 9 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 152964719 Common - putative PAS/PAC sensor protein Krad_0750 74 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152967901 Common - clavaminate synthase Krad_3958 12 None None None 152967282 Common - hypothetical protein Krad_3338 16 None None None 152967413 Common - transcriptional regulator, DeoR family Krad_3470 112 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 152964941 Common - binding-protein-dependent transport systems inner membrane component Krad_0973 141 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152965109 Common - hypothetical protein Krad_1141 14 None None None 152965936 Common - hypothetical protein Krad_1970 10 None None None 152965051 Common - protein of unknown function DUF214 Krad_1083 8 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 152967666 Common - tRNA (guanine-N(7)-)-methyltransferase Krad_3723 166 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 152965035 Common - transcription-repair coupling factor Krad_1067 218 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 152964473 Common - NAD-dependent epimerase/dehydratase Krad_0504 19 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152967059 Common - small GTP-binding protein Krad_3115 225 COG1160 COG1160, Predicted GTPases General function prediction only 152964781 Common - OsmC family protein Krad_0813 40 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 152966284 Common - regulatory protein LuxR Krad_2323 25 COG3899 COG3899, Predicted ATPase General function prediction only 152967350 Common - heat-inducible transcription repressor HrcA Krad_3406 151 COG1420 HrcA, Transcriptional regulator of heat shock gene Transcription 152967488 Nonpathogen - protein of unknown function DUF6 transmembrane Krad_3545 2 None None None 152965487 Common - Aryl-alcohol dehydrogenase (NADP(+)) Krad_1519 191 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152965498 Common - UspA domain protein Krad_1530 23 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 152966532 Common - short-chain dehydrogenase/reductase SDR Krad_2577 112 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152964294 Nonpathogen - hypothetical protein Krad_0324 5 None None None 152966820 Nonpathogen - hypothetical protein Krad_2874 8 COG2319 COG2319, FOG: WD40 repeat General function prediction only 152965038 Common - MazG family protein Krad_1070 154 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 152968429 Common - ChaB family protein Krad_4490 11 None None None 152966216 Nonpathogen - hypothetical protein Krad_2255 1 None None None 152967441 Common - isoleucyl-tRNA synthetase Krad_3498 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152967849 Nonpathogen - hypothetical protein Krad_3906 1 None None None 152964905 Common - 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase Krad_0937 140 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 152966945 Common - carbamoyl-phosphate synthase, large subunit Krad_3001 234 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 152965874 Common - phage integrase family protein Krad_1908 44 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 152968081 Common - alpha/beta hydrolase fold Krad_4138 19 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152966566 Nonpathogen - hypothetical protein Krad_2613 1 None None None 152967155 Common - transglutaminase domain protein Krad_3211 97 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 152967940 Nonpathogen - hypothetical protein Krad_3997 1 None None None 152968267 Common - short-chain dehydrogenase/reductase SDR Krad_4324 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152966701 Common - extracellular solute-binding protein family 5 Krad_2749 164 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 152968152 Common - hypothetical protein Krad_4209 18 None None None 152965901 Common - methyl-accepting chemotaxis sensory transducer Krad_1935 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152966477 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Krad_2522 99 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 152965369 Common - tRNA (guanine-N1)-methyltransferase Krad_1401 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 152965824 Common - protein of unknown function DUF1037 Krad_1858 19 COG4813 ThuA, Trehalose utilization protein Carbohydrate transport and metabolism 152964086 Common - extracellular solute-binding protein family 1 Krad_0115 41 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152963986 Nonpathogen - glycosyl transferase, group 1 Krad_0014 5 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152967678 Common - uncharacterised conserved protein UCP028846 Krad_3735 19 COG3538 COG3538, Uncharacterized conserved protein Function unknown 152965071 Common - protein of unknown function DUF255 Krad_1103 105 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 152964430 Nonpathogen - hypothetical protein Krad_0460 2 None None None 152968380 Nonpathogen - hypothetical protein Krad_4441 3 None None None 152966647 Nonpathogen - hypothetical protein Krad_2695 1 None None None 152965237 Common - ATP synthase F1, gamma subunit Krad_1269 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 152967462 Common - Glycerate kinase Krad_3519 81 COG1929 COG1929, Glycerate kinase Carbohydrate transport and metabolism 152966000 Common - hypothetical protein Krad_2035 3 None None None 152966610 Common - two component transcriptional regulator, LuxR family Krad_2658 212 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152966601 Nonpathogen - hypothetical protein Krad_2649 1 None None None 152966350 Common - CMP/dCMP deaminase zinc-binding Krad_2390 7 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 152967209 Common - aldo/keto reductase Krad_3265 198 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152964379 Common - extracellular solute-binding protein family 1 Krad_0409 17 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152967259 Nonpathogen - hypothetical protein Krad_3315 5 None None None 152965135 Common - hypothetical protein Krad_1167 17 None None None 152964120 Common - ABC transporter-related protein Krad_0149 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 152966487 Common - glycoside hydrolase family 43 Krad_2532 42 COG3507 XynB, Beta-xylosidase Carbohydrate transport and metabolism 152965552 Common - protoporphyrinogen oxidase Krad_1586 49 COG1232 HemY, Protoporphyrinogen oxidase Coenzyme metabolism 152967191 Common - DNA polymerase III, epsilon subunit Krad_3247 228 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 152964461 Common - TAP domain protein Krad_0491 39 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152964096 Common - GTP cyclohydrolase II Krad_0125 182 COG0807 RibA, GTP cyclohydrolase II Coenzyme metabolism 152967490 Common - alpha/beta hydrolase fold Krad_3547 73 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152968373 Common - transcriptional regulator Krad_4434 26 None None None 152965542 Nonpathogen - hypothetical protein Krad_1576 1 None None None 152964419 Common - Mn2+/Fe2+ transporter, NRAMP family Krad_0449 75 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 152964306 Common - diguanylate cyclase Krad_0336 175 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152966277 Common - Alpha/beta hydrolase fold-3 domain protein Krad_2316 130 COG0657 Aes, Esterase/lipase Lipid metabolism 152964522 Common - amino acid permease-associated region Krad_0553 71 COG0833 LysP, Amino acid transporters Amino acid transport and metabolism 152968039 Common - OmpA/MotB domain protein Krad_4096 43 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 152966685 Common - short-chain dehydrogenase/reductase SDR Krad_2733 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152967526 Nonpathogen - hypothetical protein Krad_3583 1 None None None 152968303 Common - ABC transporter-related protein Krad_4360 234 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 152966696 Common - uncharacterized peroxidase-related enzyme Krad_2744 25 COG4950 COG4950, Uncharacterized protein conserved in bacteria Function unknown 152966777 Nonpathogen - hypothetical protein Krad_2829 1 None None None 152966933 Common - Methionine adenosyltransferase Krad_2989 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 152968378 Common - Thymidylate synthase Krad_4439 143 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 152965946 Common - integral membrane sensor signal transduction histidine kinase Krad_1980 63 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152964286 Nonpathogen - hypothetical protein Krad_0316 1 None None None 152964862 Common - phosphate uptake regulator, PhoU Krad_0894 197 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 152964732 Common - YbaK/prolyl-tRNA synthetase associated region Krad_0764 41 COG2606 EbsC, Uncharacterized conserved protein Function unknown 152965629 Common - flagellar motor switch protein FliM Krad_1663 98 COG1868 FliM, Flagellar motor switch protein Cell motility and secretion 152968035 Common - extracellular solute-binding protein family 1 Krad_4092 42 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152967852 Common - periplasmic binding protein Krad_3909 48 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 152966115 Nonpathogen - hypothetical protein Krad_2151 1 None None None 152964270 Common - Mannitol dehydrogenase domain Krad_0300 88 COG0246 MtlD, Mannitol-1-phosphate/altronate dehydrogenases Carbohydrate transport and metabolism 152967903 Nonpathogen - secreted protein Krad_3960 7 None None None 152964102 Common - SCP-like extracellular protein Krad_0131 17 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 152965523 Common - deoxyuridine 5'-triphosphate nucleotidohydrolase Dut Krad_1557 177 COG0756 Dut, dUTPase Nucleotide transport and metabolism 152966203 Nonpathogen - AAA ATPase Krad_2242 5 None None None 152966509 Common - metallophosphoesterase Krad_2554 37 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 152968117 Common - ABC transporter-related protein Krad_4174 249 COG4152 COG4152, ABC-type uncharacterized transport system, ATPase component General function prediction only 152967018 Common - malto-oligosyltrehalose synthase Krad_3074 58 COG3280 TreY, Maltooligosyl trehalose synthase Carbohydrate transport and metabolism 152967596 Common - binding-protein-dependent transport systems inner membrane component Krad_3653 100 COG2011 AbcD, ABC-type metal ion transport system, permease component Inorganic ion transport and metabolism 152965060 Common - Cystathionine gamma-synthase Krad_1092 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 152967115 Nonpathogen - DoxX family protein Krad_3171 2 COG2259 COG2259, Predicted membrane protein Function unknown 152967583 Common - Aldose 1-epimerase Krad_3640 99 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 152964889 Common - protein kinase Krad_0921 146 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 152965394 Common - hypothetical protein Krad_1426 18 COG3591 COG3591, V8-like Glu-specific endopeptidase Amino acid transport and metabolism 152965222 Common - homoserine kinase Krad_1254 64 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 152966937 Common - hypothetical protein Krad_2993 16 None None None 152967183 Common - putative glucokinase, ROK family Krad_3239 139 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 152965593 Common - flagellar hook-associated 2 domain protein Krad_1627 50 COG1345 FliD, Flagellar capping protein Cell motility and secretion 152967628 Common - GCN5-related N-acetyltransferase Krad_3685 107 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 152967694 Common - hypothetical protein Krad_3751 4 None None None 152967173 Common - Squalene/phytoene synthase Krad_3229 105 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 152965722 Nonpathogen - hypothetical protein Krad_1756 1 None None None 152968371 Nonpathogen - putative DNA polymerase III Krad_4432 1 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 152966640 Nonpathogen - hypothetical protein Krad_2688 1 None None None 152964933 Common - extracellular solute-binding protein family 1 Krad_0965 44 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152965075 Common - PhoH family protein Krad_1107 199 COG1875 COG1875, Predicted ATPase related to phosphate starvation-inducible protein PhoH Signal transduction mechanisms 152967757 Common - integral membrane sensor signal transduction histidine kinase Krad_3814 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152968364 Nonpathogen - ADP-ribosylglycohydrolase Krad_4425 3 None None None 152964778 Common - hypothetical protein Krad_0810 11 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 152964880 Common - RNA methyltransferase, TrmH family, group 3 Krad_0912 213 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 152968024 Common - putative Zn-dependent hydrolase Krad_4081 40 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 152965730 Nonpathogen - hypothetical protein Krad_1764 1 None None None 152967252 Common - stress protein Krad_3308 28 COG2310 TerZ, Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 Signal transduction mechanisms 152968102 Common - diguanylate cyclase Krad_4159 171 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152966010 Common - VWA containing CoxE family protein Krad_2045 25 COG2425 COG2425, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 152965258 Common - ABC transporter-related protein Krad_1290 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 152968047 Common - hypothetical protein Krad_4104 17 COG5542 COG5542, Predicted integral membrane protein Function unknown 152965362 Common - nitrogen regulatory protein P-II Krad_1394 187 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 152966391 Common - putative GAF sensor protein Krad_2431 13 COG2203 FhlA, FOG: GAF domain Signal transduction mechanisms 152968323 Common - exsB protein Krad_4380 177 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 152967839 Common - ABC transporter-related protein Krad_3896 247 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 152965992 Common - bifunctional deaminase-reductase domain protein Krad_2027 30 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 152967197 Common - Cytochrome b/b6 domain Krad_3253 149 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 152965400 Common - amine oxidase Krad_1432 24 COG1231 COG1231, Monoamine oxidase Amino acid transport and metabolism 152967124 Nonpathogen - hypothetical protein Krad_3180 1 None None None 152966153 Common - short-chain dehydrogenase/reductase SDR Krad_2190 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152965976 Common - diguanylate cyclase Krad_2011 172 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152966388 Common - NADH:flavin oxidoreductase/NADH oxidase Krad_2428 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 152967976 Common - Phytanoyl-CoA dioxygenase Krad_4033 15 COG5285 COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin Secondary metabolites biosynthesis, transport, and catabolism 152966374 Nonpathogen - hypothetical protein Krad_2414 2 None None None 152965748 Common - UDP-N-acetylmuramyl-tripeptide synthetase Krad_1782 210 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 152968401 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Krad_4462 170 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152965862 Common - transcriptional regulator, CdaR Krad_1896 19 COG3835 CdaR, Sugar diacid utilization regulator Transcription / Signal transduction mechanisms 152964038 Common - integral membrane protein Krad_0067 9 None None None 152965016 Common - Undecaprenyl-phosphate galactose phosphotransferase Krad_1048 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 152966710 Common - TPR repeat-containing protein Krad_2758 18 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 152965383 Common - ribosomal protein S2 Krad_1415 218 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 152964134 Common - hypothetical protein Krad_0163 4 None None None 152966046 Common - Amidase Krad_2081 116 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 152968213 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Krad_4270 6 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 152965144 Common - NUDIX hydrolase Krad_1176 98 COG2816 NPY1, NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding DNA replication, recombination, and repair 152967331 Common - PhoH family protein Krad_3387 199 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 152965755 Common - beta-lactamase domain protein Krad_1789 159 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 152965417 Common - tRNA pseudouridine synthase B Krad_1449 241 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 152965890 Nonpathogen - hypothetical protein Krad_1924 2 None None None 152967962 Common - major facilitator superfamily MFS_1 Krad_4019 108 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 152966192 Common - binding-protein-dependent transport systems inner membrane component Krad_2231 153 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152965785 Common - glycosyl transferase group 1 Krad_1819 39 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152965218 Common - arginyl-tRNA synthetase Krad_1250 242 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152965610 Common - peptidase M48 Ste24p Krad_1644 15 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 152966525 Nonpathogen - hypothetical protein Krad_2570 1 None None None 152966764 Common - short-chain dehydrogenase/reductase SDR Krad_2814 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152967399 Common - ribosomal protein L27 Krad_3456 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 152967226 Common - amine oxidase Krad_3282 20 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 152965535 Common - putative signal transduction protein Krad_1569 50 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 152964913 Common - aminotransferase class I and II Krad_0945 236 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 152966538 Common - Alanine racemase Krad_2584 126 COG1609 PurR, Transcriptional regulators Transcription 152966622 Common - periplasmic binding protein Krad_2670 68 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 152965619 Common - ATPase, FliI/YscN family Krad_1653 247 COG1157 FliI, Flagellar biosynthesis/type III secretory pathway ATPase Cell motility and secretion / Intracellular trafficking and secretion 152964022 Common - transcriptional regulator, TetR family Krad_0051 56 COG1309 AcrR, Transcriptional regulator Transcription 152965342 Common - protein of unknown function DUF177 Krad_1374 29 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 152965354 Common - rhamnulose-1-phosphate aldolase/alcohol dehydrogenase Krad_1386 236 COG3347 COG3347, Uncharacterized conserved protein Function unknown 152964826 Common - DEAD/DEAH box helicase domain protein Krad_0858 231 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 152966071 Nonpathogen - hypothetical protein Krad_2106 1 None None None 152967958 Common - extracellular solute-binding protein family 1 Krad_4015 106 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152965601 Common - aldehyde dehydrogenase Krad_1635 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 152966494 Common - glycoside hydrolase family 3 domain protein Krad_2539 142 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 152968339 Common - extracellular solute-binding protein family 1 Krad_4400 63 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152964838 Common - protein of unknown function DUF47 Krad_0870 66 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 152965995 Nonpathogen - GCN5-related N-acetyltransferase Krad_2030 3 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 152965323 Nonpathogen - hypothetical protein Krad_1355 1 None None None 152967177 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Krad_3233 73 COG3200 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 152968283 Nonpathogen - integral membrane protein Krad_4340 5 COG5650 COG5650, Predicted integral membrane protein Function unknown 152965245 Common - Threonine aldolase Krad_1277 115 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 152964480 Common - Alcohol dehydrogenase zinc-binding domain protein Krad_0511 207 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 152967091 Common - DNA repair protein RecN Krad_3147 197 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 152968197 Common - short-chain dehydrogenase/reductase SDR Krad_4254 222 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152967660 Nonpathogen - hypothetical protein Krad_3717 1 None None None 152965687 Nonpathogen - hypothetical protein Krad_1721 2 None None None 152966124 Common - ROK family protein Krad_2160 6 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 152968040 Nonpathogen - hypothetical protein Krad_4097 2 None None None 152966104 Common - Hydroxypyruvate isomerase Krad_2140 73 COG3622 Hfi, Hydroxypyruvate isomerase Carbohydrate transport and metabolism 152965867 Common - Inosine/uridine-preferring nucleoside hydrolase Krad_1901 85 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 152967297 Common - threonine dehydratase Krad_3353 188 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 152964023 Common - protein of unknown function DUF6 transmembrane Krad_0052 30 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 152964707 Common - putative transcriptional regulator, MerR family Krad_0738 12 COG0789 SoxR, Predicted transcriptional regulators Transcription 152965793 Common - GDP-mannose 4,6-dehydratase Krad_1827 225 COG1089 Gmd, GDP-D-mannose dehydratase Cell envelope biogenesis, outer membrane 152966205 Nonpathogen - hypothetical protein Krad_2244 1 None None None 152966529 Common - transcriptional regulator, TetR family Krad_2574 49 COG1309 AcrR, Transcriptional regulator Transcription 152965101 Common - GTP-binding protein TypA Krad_1133 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 152966482 Common - glycoside hydrolase family 2 sugar binding Krad_2527 70 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 152965943 Common - ABC transporter-related protein Krad_1977 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 152966778 Nonpathogen - hypothetical protein Krad_2830 1 None None None 152964713 Common - short-chain dehydrogenase/reductase SDR Krad_0744 197 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152966800 Common - GCN5-related N-acetyltransferase Krad_2853 6 COG0456 RimI, Acetyltransferases General function prediction only 152964030 Common - LGFP repeat protein Krad_0059 13 COG5479 COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis Cell envelope biogenesis, outer membrane 152966369 Common - Stage II sporulation E family protein Krad_2409 92 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152965990 Common - putative PAS/PAC sensor protein Krad_2025 134 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152966633 Common - transcriptional regulator, GntR family Krad_2681 112 COG1802 GntR, Transcriptional regulators Transcription 152967022 Common - AFG1-family ATPase Krad_3078 93 COG1485 COG1485, Predicted ATPase General function prediction only 152968015 Common - aspartate racemase Krad_4072 70 COG1794 RacX, Aspartate racemase Cell envelope biogenesis, outer membrane 152967109 Common - PAS/PAC sensor signal transduction histidine kinase Krad_3165 221 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 152966022 Common - hypothetical protein Krad_2057 16 None None None 152965304 Common - acetolactate synthase, small subunit Krad_1336 193 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 152964058 Common - hypothetical protein Krad_0087 26 COG3044 COG3044, Predicted ATPase of the ABC class General function prediction only 152968300 Nonpathogen - hypothetical protein Krad_4357 1 None None None 152966733 Common - binding-protein-dependent transport systems inner membrane component Krad_2783 58 COG3639 COG3639, ABC-type phosphate/phosphonate transport system, permease component Inorganic ion transport and metabolism 152968095 Common - ABC transporter-related protein Krad_4152 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 152968411 Nonpathogen - hypothetical protein Krad_4472 1 None None None 152964325 Common - hypothetical protein Krad_0355 2 COG4118 Phd, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 152967899 Common - ABC-1 domain protein Krad_3956 185 COG0661 AarF, Predicted unusual protein kinase General function prediction only 152965999 Common - transcriptional regulator, XRE family Krad_2034 61 COG1476 COG1476, Predicted transcriptional regulators Transcription 152968404 Common - methyl-accepting chemotaxis sensory transducer Krad_4465 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152964937 Nonpathogen - hypothetical protein Krad_0969 4 None None None 152968348 Nonpathogen - hypothetical protein Krad_4409 5 None None None 152966910 Common - Indole-3-glycerol-phosphate synthase Krad_2966 219 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 152967825 Common - UbiA prenyltransferase Krad_3882 61 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 152968334 Nonpathogen - hypothetical protein Krad_4395 1 None None None 152964801 Common - Agmatine deiminase Krad_0833 87 COG2957 COG2957, Peptidylarginine deiminase and related enzymes Amino acid transport and metabolism 152965617 Common - flagellar motor switch protein FliG Krad_1651 125 COG1536 FliG, Flagellar motor switch protein Cell motility and secretion 152965380 Common - peptidase M23B Krad_1412 18 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 152965050 Common - cystathionine beta-synthase Krad_1082 221 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 152966411 Common - response regulator receiver protein Krad_2452 45 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152965541 Common - UDP-N-acetylglucosamine pyrophosphorylase related protein Krad_1575 12 COG1213 COG1213, Predicted sugar nucleotidyltransferases Cell envelope biogenesis, outer membrane 152965313 Common - dibenzothiophene desulfurization enzyme A Krad_1345 64 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152965972 Common - putative PAS/PAC sensor protein Krad_2007 158 COG2202 AtoS, FOG: PAS/PAC domain Signal transduction mechanisms 152964860 Common - glycosyl transferase group 1 Krad_0892 175 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152965893 Nonpathogen - hypothetical protein Krad_1927 1 None None None 152964730 Nonpathogen - hypothetical protein Krad_0761 1 None None None 152965013 Common - dimethyladenosine transferase Krad_1045 246 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 152966063 Common - Saccharopine dehydrogenase Krad_2098 49 COG3268 COG3268, Uncharacterized conserved protein Function unknown 152965372 Common - signal peptidase I Krad_1404 170 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 152968285 Common - hypothetical protein Krad_4342 18 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 152964205 Common - diguanylate cyclase/phosphodiesterase Krad_0235 176 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152966117 Common - short-chain dehydrogenase/reductase SDR Krad_2153 218 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152968109 Nonpathogen - hypothetical protein Krad_4166 1 None None None 152964050 Common - ThiJ/PfpI domain protein Krad_0079 106 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 152965155 Common - ABC transporter-related protein Krad_1187 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 152967856 Nonpathogen - hypothetical protein Krad_3913 1 None None None 152967721 Common - ABC transporter-related protein Krad_3778 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 152967179 Common - phospholipid/glycerol acyltransferase Krad_3235 148 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 152967667 Common - major facilitator superfamily MFS_1 Krad_3724 38 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 152967290 Common - Beta-ketoacyl synthase Krad_3346 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152964213 Common - putative integral membrane protein Krad_0243 12 None None None 152965122 Common - twin-arginine translocation protein, TatB subunit Krad_1154 12 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 152964026 Nonpathogen - hypothetical protein Krad_0055 1 None None None 152964340 Common - Fibronectin type III domain protein Krad_0370 34 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 152964444 Nonpathogen - hypothetical protein Krad_0474 1 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 152967599 Common - amidohydrolase Krad_3656 43 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 152964869 Common - amino acid permease-associated region Krad_0901 21 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 152967979 Common - PHP domain protein Krad_4036 60 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 152965346 Common - binding-protein-dependent transport systems inner membrane component Krad_1378 145 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152965615 Common - flagellar hook-basal body complex subunit FliE Krad_1649 53 COG1677 FliE, Flagellar hook-basal body protein Cell motility and secretion / Intracellular trafficking and secretion 152966489 Common - major facilitator superfamily MFS_1 Krad_2534 21 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 152964704 Common - chaperonin Cpn10 Krad_0735 216 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 152967763 Common - protein of unknown function DUF58 Krad_3820 47 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 152968301 Common - hypothetical protein Krad_4358 3 None None None 152964620 Common - methyl-accepting chemotaxis sensory transducer Krad_0651 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152964066 Nonpathogen - hypothetical protein Krad_0095 1 None None None 152967681 Common - transcriptional regulator, MarR family Krad_3738 77 COG1846 MarR, Transcriptional regulators Transcription 152965073 Common - extracellular solute-binding protein family 1 Krad_1105 79 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152965364 Common - signal recognition particle protein Krad_1396 246 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 152968443 Common - thioredoxin Krad_4504 233 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 152968328 Nonpathogen - hypothetical protein Krad_4386 3 None None None 152966182 Common - transcriptional regulator, TetR family Krad_2221 69 COG1309 AcrR, Transcriptional regulator Transcription 152965407 Nonpathogen - hypothetical protein Krad_1439 1 None None None 152966015 Nonpathogen - hypothetical protein Krad_2050 1 None None None 152967758 Common - two component transcriptional regulator, winged helix family Krad_3815 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152966408 Nonpathogen - hypothetical protein Krad_2449 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 152967255 Common - stress protein Krad_3311 30 COG2310 TerZ, Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 Signal transduction mechanisms 152968100 Common - Xylose isomerase domain protein TIM barrel Krad_4157 73 COG3622 Hfi, Hydroxypyruvate isomerase Carbohydrate transport and metabolism 152968434 Common - NUDIX hydrolase Krad_4495 13 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 152966739 Common - short-chain dehydrogenase/reductase SDR Krad_2789 212 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152965798 Common - Mg2 transporter protein CorA family protein Krad_1832 163 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 152965385 Common - uridylate kinase Krad_1417 231 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 152968107 Common - hypothetical protein Krad_4164 6 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 152964126 Common - major facilitator superfamily MFS_1 Krad_0155 59 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 152964098 Common - transcriptional regulator, TetR family Krad_0127 60 COG1309 AcrR, Transcriptional regulator Transcription 152967192 Common - putative transcriptional regulator, AsnC family Krad_3248 30 COG1522 Lrp, Transcriptional regulators Transcription 152964048 Common - FHA domain containing protein Krad_0077 58 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 152968046 Common - GCN5-related N-acetyltransferase Krad_4103 46 COG0456 RimI, Acetyltransferases General function prediction only 152965511 Common - hypothetical protein Krad_1545 14 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152964762 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_0794 55 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152965842 Common - peptidylprolyl isomerase FKBP-type Krad_1876 110 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 152965412 Common - protein of unknown function DUF503 Krad_1444 11 COG1550 COG1550, Uncharacterized protein conserved in bacteria Function unknown 152967497 Common - Deoxyribodipyrimidine photo-lyase Krad_3554 131 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 152967077 Nonpathogen - type II secretion system protein Krad_3133 6 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 152967299 Nonpathogen - hypothetical protein Krad_3355 1 None None None 152965746 Nonpathogen - hypothetical protein Krad_1780 1 None None None 152968043 Common - phosphoribosylamine--glycine ligase Krad_4100 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 152966043 Common - Serine--pyruvate transaminase Krad_2078 152 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 152967905 Common - binding-protein-dependent transport systems inner membrane component Krad_3962 156 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152968034 Common - binding-protein-dependent transport systems inner membrane component Krad_4091 142 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152966502 Nonpathogen - hypothetical protein Krad_2547 1 None None None 152966320 Nonpathogen - aminoglycoside phosphotransferase Krad_2360 2 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 152968139 Common - short-chain dehydrogenase/reductase SDR Krad_4196 76 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152964027 Nonpathogen - hypothetical protein Krad_0056 2 None None None 152967095 Nonpathogen - hypothetical protein Krad_3151 4 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 152967114 Common - hypothetical protein Krad_3170 9 None None None 152967581 Common - hypothetical protein Krad_3638 16 None None None 152964549 Common - putative ABC transporter transmembrane protein Krad_0580 7 None None None 152965719 Nonpathogen - hypothetical protein Krad_1753 1 None None None 152964709 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_0740 82 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152964542 Common - metal dependent phosphohydrolase Krad_0573 130 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 152967270 Nonpathogen - hypothetical protein Krad_3326 1 None None None 152968365 Nonpathogen - hypothetical protein Krad_4426 1 None None None 152965653 Nonpathogen - hypothetical protein Krad_1687 1 None None None 152966401 Common - diguanylate cyclase with PAS/PAC sensor Krad_2442 179 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152964737 Nonpathogen - hypothetical protein Krad_0769 1 COG5305 COG5305, Predicted membrane protein Function unknown 152968292 Common - 2,5-didehydrogluconate reductase Krad_4349 188 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 152964859 Common - phosphoglycerate mutase 1 family Krad_0891 130 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 152966826 Nonpathogen - parallel beta-helix repeat Krad_2880 10 None None None 152965261 Common - Substrate-binding region of ABC-type glycine betaine transport system Krad_1293 88 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 152967853 Common - protein of unknown function DUF885 Krad_3910 41 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 152967279 Common - protein of unknown function DUF164 Krad_3335 24 COG1579 COG1579, Zn-ribbon protein, possibly nucleic acid-binding General function prediction only 152965637 Common - multi-sensor signal transduction histidine kinase Krad_1671 209 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 152966265 Common - NADP oxidoreductase coenzyme F420-dependent Krad_2304 45 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 152964578 Common - Ppx/GppA phosphatase Krad_0609 172 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 152964429 Common - hypothetical protein Krad_0459 23 None None None 152965663 Nonpathogen - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_1697 1 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152965780 Common - luciferase family protein Krad_1814 117 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152968130 Common - Acetyl xylan esterase Krad_4187 20 COG3458 COG3458, Acetyl esterase (deacetylase) Secondary metabolites biosynthesis, transport, and catabolism 152968427 Common - transcriptional regulator, TetR family Krad_4488 53 COG1309 AcrR, Transcriptional regulator Transcription 152965220 Common - Homoserine dehydrogenase Krad_1252 216 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 152968026 Common - pyridine nucleotide-disulphide oxidoreductase dimerisation region Krad_4083 231 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 152964853 Nonpathogen - AmfC protein Krad_0885 4 None None None 152964722 Common - hypothetical protein Krad_0753 15 None None None 152967011 Nonpathogen - hypothetical protein Krad_3067 6 COG3217 COG3217, Uncharacterized Fe-S protein General function prediction only 152965738 Nonpathogen - hypothetical protein Krad_1772 1 None None None 152968353 Common - DNA mismatch endonuclease vsr Krad_4414 69 COG3727 Vsr, DNA G:T-mismatch repair endonuclease DNA replication, recombination, and repair 152967861 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Krad_3918 244 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 152965221 Common - threonine synthase Krad_1253 128 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 152964083 Common - ROK family protein Krad_0112 157 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 152966241 Nonpathogen - hypothetical protein Krad_2280 1 None None None 152964153 Common - thiamine pyrophosphate protein TPP binding domain protein Krad_0182 216 COG3961 COG3961, Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only 152966226 Nonpathogen - hypothetical protein Krad_2265 1 None None None 152966235 Nonpathogen - hypothetical protein Krad_2274 1 None None None 152967485 Common - ABC transporter-related protein Krad_3542 245 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 152965005 Common - Alpha-N-arabinofuranosidase Krad_1037 31 COG3534 AbfA, Alpha-L-arabinofuranosidase Carbohydrate transport and metabolism 152965666 Nonpathogen - hypothetical protein Krad_1700 1 None None None 152965509 Common - FAD dependent oxidoreductase Krad_1543 60 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 152966077 Nonpathogen - hypothetical protein Krad_2112 1 None None None 152967966 Common - short-chain dehydrogenase/reductase SDR Krad_4023 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152967807 Common - hypothetical protein Krad_3864 7 COG0392 COG0392, Predicted integral membrane protein Function unknown 152967552 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_3609 114 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152965066 Common - protein of unknown function UPF0118 Krad_1098 111 COG0628 PerM, Predicted permease General function prediction only 152967480 Common - Phosphoenolpyruvate carboxykinase (GTP) Krad_3537 59 COG1274 PckA, Phosphoenolpyruvate carboxykinase (GTP) Energy production and conversion 152966729 Common - short-chain dehydrogenase/reductase SDR Krad_2779 45 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152966517 Nonpathogen - hypothetical protein Krad_2562 1 None None None 152964478 Common - alpha/beta hydrolase fold Krad_0509 28 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152964529 Common - hypothetical protein Krad_0560 4 None None None 152964607 Common - diguanylate cyclase/phosphodiesterase Krad_0638 175 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152967661 Nonpathogen - hypothetical protein Krad_3718 1 None None None 152964969 Common - FAD linked oxidase domain protein Krad_1001 175 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 152964337 Nonpathogen - hypothetical protein Krad_0367 7 None None None 152964194 Common - response regulator receiver and ANTAR domain protein Krad_0223 11 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 152966913 Common - Phosphoribosyl-AMP cyclohydrolase Krad_2969 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 152964551 Common - Altronate dehydratase Krad_0582 73 COG2721 UxaA, Altronate dehydratase Carbohydrate transport and metabolism 152968257 Common - transcriptional regulator, TetR family Krad_4314 5 COG3226 COG3226, Uncharacterized protein conserved in bacteria Function unknown 152966907 Common - DSBA oxidoreductase Krad_2963 14 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 152967792 Nonpathogen - hypothetical protein Krad_3849 1 None None None 152964962 Common - exodeoxyribonuclease V, alpha subunit Krad_0994 112 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 152966921 Common - 6,7-dimethyl-8-ribityllumazine synthase Krad_2977 205 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 152967465 Common - ribose 5-phosphate isomerase Krad_3522 127 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 152966003 Nonpathogen - hypothetical protein Krad_2038 1 None None None 152965236 Common - ATP synthase F1, alpha subunit Krad_1268 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 152966311 Common - aminoglycoside phosphotransferase Krad_2351 18 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 152965119 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_1151 174 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152966172 Common - transcriptional regulator, TetR family Krad_2211 26 COG1309 AcrR, Transcriptional regulator Transcription 152966276 Nonpathogen - hypothetical protein Krad_2315 1 None None None 152965215 Common - Glutathione peroxidase Krad_1247 114 COG0386 BtuE, Glutathione peroxidase Posttranslational modification, protein turnover, chaperones 152966318 Nonpathogen - hypothetical protein Krad_2358 1 None None None 152964433 Common - aspartate kinase Krad_0463 233 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 152968299 Nonpathogen - protein of unknown function UPF0157 Krad_4356 1 None None None 152964278 Common - Quinone oxidoreductase putative PIG3 Krad_0308 186 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 152967203 Common - Cytochrome c oxidase subunit II Krad_3259 139 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 152966975 Common - Holliday junction resolvase YqgF Krad_3031 57 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 152964896 Common - polar amino acid ABC transporter, inner membrane subunit Krad_0928 175 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 152965096 Common - ABC transporter-related protein Krad_1128 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 152966379 Nonpathogen - hypothetical protein Krad_2419 1 None None None 152967797 Common - hypothetical protein Krad_3854 15 COG0122 AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 152965477 Common - protein of unknown function DUF75 Krad_1509 21 COG1938 COG1938, Archaeal enzymes of ATP-grasp superfamily General function prediction only 152967468 Common - aminopeptidase N Krad_3525 154 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 152967019 Common - malto-oligosyltrehalose trehalohydrolase Krad_3075 135 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 152967674 Common - binding-protein-dependent transport systems inner membrane component Krad_3731 138 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152965274 Common - glycogen debranching enzyme GlgX Krad_1306 128 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 152966850 Common - hypothetical protein Krad_2906 8 None None None 152965721 Nonpathogen - hypothetical protein Krad_1755 1 None None None 152968198 Common - transcriptional regulator, TetR family Krad_4255 49 COG1309 AcrR, Transcriptional regulator Transcription 152966334 Common - hypothetical protein Krad_2374 14 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 152966191 Common - binding-protein-dependent transport systems inner membrane component Krad_2230 142 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152964381 Common - binding-protein-dependent transport systems inner membrane component Krad_0411 143 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152965522 Common - membrane protein Krad_1556 14 None None None 152966230 Nonpathogen - hypothetical protein Krad_2269 1 None None None 152967158 Common - Methyltransferase type 12 Krad_3214 7 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152967925 Common - isochorismate synthase Krad_3982 223 COG1169 MenF, Isochorismate synthase Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152967968 Nonpathogen - hypothetical protein Krad_4025 1 None None None 152966070 Common - Na+/H+ antiporter NhaA Krad_2105 103 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 152964687 Common - putative phosphohistidine phosphatase, SixA Krad_0718 16 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 152964832 Nonpathogen - hypothetical protein Krad_0864 1 None None None 152964629 Common - peptidase M48 Ste24p Krad_0660 189 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 152964483 Common - homoserine O-acetyltransferase Krad_0514 132 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 152967368 Common - Amidohydrolase 3 Krad_3425 72 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 152965866 Common - nitroreductase Krad_1900 31 COG0778 NfnB, Nitroreductase Energy production and conversion 152965212 Common - ATP-dependent helicase HrpB Krad_1244 131 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 152966792 Nonpathogen - hypothetical protein Krad_2844 1 None None None 152967133 Common - lipoprotein signal peptidase Krad_3189 47 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 152966354 Nonpathogen - hypothetical protein Krad_2394 1 None None None 152964321 Common - diguanylate cyclase/phosphodiesterase Krad_0351 169 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152966863 Common - ABC transporter-related protein Krad_2919 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 152965607 Common - cytochrome d ubiquinol oxidase, subunit II Krad_1641 145 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 152964271 Common - binding-protein-dependent transport systems inner membrane component Krad_0301 157 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152966092 Common - Mandelate racemase/muconate lactonizing protein Krad_2128 99 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 152968385 Nonpathogen - hypothetical protein Krad_4446 2 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152967838 Common - carbohydrate kinase FGGY Krad_3895 179 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 152967314 Common - ferric uptake regulator, Fur family Krad_3370 190 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 152965180 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_1212 168 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152965713 Nonpathogen - hypothetical protein Krad_1747 1 COG1043 LpxA, Acyl- acyl carrier protein 152966245 Nonpathogen - hypothetical protein Krad_2284 1 None None None 152966623 Nonpathogen - hypothetical protein Krad_2671 1 None None None 152964351 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Krad_0381 210 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 152968392 Common - histidine ammonia-lyase Krad_4453 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 152966771 Common - protein of unknown function DUF6 transmembrane Krad_2821 18 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 152967287 Common - Acyl transferase Krad_3343 179 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 152965681 Nonpathogen - hypothetical protein Krad_1715 1 None None None 152964172 Common - 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase Krad_0201 125 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 152966474 Common - integral membrane sensor signal transduction histidine kinase Krad_2519 30 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152968170 Common - aminoglycoside phosphotransferase Krad_4227 11 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 152964090 Common - alpha-L-rhamnosidase Krad_0119 23 None None None 152966962 Nonpathogen - Fimbrial assembly family protein Krad_3018 1 COG3166 PilN, Tfp pilus assembly protein PilN Cell motility and secretion / Intracellular trafficking and secretion 152965747 Nonpathogen - hypothetical protein Krad_1781 1 None None None 152966130 Common - binding-protein-dependent transport systems inner membrane component Krad_2167 150 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152965566 Common - 2,5-didehydrogluconate reductase Krad_1600 168 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 152964776 Common - hypothetical protein Krad_0808 18 None None None 152965032 Common - glycosyl transferase group 1 Krad_1064 163 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152965421 Common - protein of unknown function DUF477 Krad_1453 9 COG1512 COG1512, Beta-propeller domains of methanol dehydrogenase type General function prediction only 152966520 Nonpathogen - hypothetical protein Krad_2565 1 None None None 152965787 Common - glycosyl transferase family 2 Krad_1821 140 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152967608 Nonpathogen - hypothetical protein Krad_3665 1 None None None 152966107 Common - binding-protein-dependent transport systems inner membrane component Krad_2143 148 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152967916 Common - galactokinase Krad_3973 82 COG0153 GalK, Galactokinase Carbohydrate transport and metabolism 152963980 Common - hypothetical protein Krad_0008 18 None None None 152966668 Common - Cupin 2 conserved barrel domain protein Krad_2716 67 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 152968212 Common - aldo/keto reductase Krad_4269 189 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152965087 Common - fructose-1,6-bisphosphatase, class II Krad_1119 112 COG1494 GlpX, Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins Carbohydrate transport and metabolism 152966027 Nonpathogen - amidohydrolase 2 Krad_2062 2 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 152964100 Common - transcriptional regulator, LysR family Krad_0129 150 COG0583 LysR, Transcriptional regulator Transcription 152967421 Common - GCN5-related N-acetyltransferase Krad_3478 29 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 152965635 Common - type III secretion exporter Krad_1669 129 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 152967058 Common - protein of unknown function UPF0060 Krad_3114 78 COG1742 COG1742, Uncharacterized conserved protein Function unknown 152964915 Common - putative PAS/PAC sensor protein Krad_0947 144 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152965598 Common - putative PAS/PAC sensor protein Krad_1632 58 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152968190 Common - TrkA-N domain protein Krad_4247 99 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 152968272 Common - MIP family channel protein Krad_4329 123 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 152968358 Common - DNA polymerase III, epsilon subunit Krad_4419 185 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 152967824 Common - GtrA family protein Krad_3881 11 COG2246 COG2246, Predicted membrane protein Function unknown 152965146 Common - glutaredoxin-like protein Krad_1178 28 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 152964248 Common - putative signal transduction histidine kinase Krad_0278 13 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152966324 Nonpathogen - hypothetical protein Krad_2364 1 None None None 152966444 Common - 3-isopropylmalate dehydrogenase Krad_2488 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 152964887 Common - HAD-superfamily hydrolase, subfamily IIB Krad_0919 72 COG1877 OtsB, Trehalose-6-phosphatase Carbohydrate transport and metabolism 152965974 Common - putative PAS/PAC sensor protein Krad_2009 94 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152964964 Nonpathogen - hypothetical protein Krad_0996 1 None None None 152966457 Nonpathogen - hypothetical protein Krad_2501 1 None None None 152966155 Nonpathogen - Methyltransferase type 12 Krad_2192 3 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 152966810 Common - transcriptional regulator, MarR family Krad_2864 6 COG1846 MarR, Transcriptional regulators Transcription 152966861 Common - FeS assembly protein SufB Krad_2917 186 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 152964696 Common - alanine racemase Krad_0727 199 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 152966048 Common - hypothetical protein Krad_2083 7 None None None 152965337 Common - ABC transporter-related protein Krad_1369 248 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 152964349 Common - CMP/dCMP deaminase zinc-binding Krad_0379 45 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 152965485 Common - putative ribonuclease BN Krad_1517 80 COG1295 Rbn, Predicted membrane protein Function unknown 152967611 Common - Glycosyltransferase 28 domain Krad_3668 20 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 152964679 Common - methionine aminopeptidase, type I Krad_0710 217 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 152967700 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Krad_3757 205 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 152964301 Nonpathogen - Hpt domain protein Krad_0331 1 None None None 152964007 Nonpathogen - putative integral membrane protein Krad_0035 1 None None None 152965042 Common - Septum formation initiator Krad_1074 18 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 152964590 Common - Aldose 1-epimerase Krad_0621 94 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 152964987 Common - osmosensitive K+ channel signal transduction histidine kinase Krad_1019 156 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 152967359 Common - luciferase family protein Krad_3415 82 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152964635 Common - major facilitator superfamily MFS_1 Krad_0666 45 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 152966644 Common - secreted protein Krad_2692 15 COG1409 Icc, Predicted phosphohydrolases General function prediction only 152968004 Common - sugar transporter Krad_4061 99 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152966472 Common - protein of unknown function DUF418 Krad_2517 4 COG2311 COG2311, Predicted membrane protein Function unknown 152964783 Common - Catalase Krad_0815 46 COG3546 COG3546, Mn-containing catalase Inorganic ion transport and metabolism 152967936 Common - Alkanesulfonate monooxygenase Krad_3993 73 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152966915 Common - imidazoleglycerol phosphate synthase, cyclase subunit Krad_2971 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 152964265 Common - binding-protein-dependent transport systems inner membrane component Krad_0295 141 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152966282 Nonpathogen - protein of unknown function DUF214 Krad_2321 1 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 152964006 Common - hypothetical protein Krad_0034 8 None None None 152965565 Nonpathogen - hypothetical protein Krad_1599 1 None None None 152964637 Nonpathogen - regulatory protein GntR HTH Krad_0668 1 COG1725 COG1725, Predicted transcriptional regulators Transcription 152967569 Common - thiamineS protein Krad_3626 3 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 152965957 Common - PRC-barrel domain protein Krad_1991 9 COG3861 COG3861, Uncharacterized protein conserved in bacteria Function unknown 152967510 Common - Alpha-N-arabinofuranosidase Krad_3567 29 COG3534 AbfA, Alpha-L-arabinofuranosidase Carbohydrate transport and metabolism 152966033 Common - hypothetical protein Krad_2068 15 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 152968394 Common - Acetamidase/Formamidase Krad_4455 66 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 152964974 Common - diguanylate phosphodiesterase Krad_1006 14 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152965475 Nonpathogen - peptidoglycan-binding LysM Krad_1507 2 None None None 152966586 Common - L-carnitine dehydratase/bile acid-inducible protein F Krad_2634 108 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 152965459 Common - Gluconolactonase Krad_1491 70 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 152966929 Common - peptide deformylase Krad_2985 209 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 152965267 Common - adenosine deaminase Krad_1299 97 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 152968167 Nonpathogen - hypothetical protein Krad_4224 1 None None None 152964151 Common - Alkaline phosphatase Krad_0180 86 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 152966125 Common - sugar isomerase (SIS) Krad_2161 128 COG2222 AgaS, Predicted phosphosugar isomerases Cell envelope biogenesis, outer membrane 152966676 Common - peptidase M6 immune inhibitor A Krad_2724 18 COG4412 COG4412, Uncharacterized protein conserved in bacteria Function unknown 152966305 Nonpathogen - hypothetical protein Krad_2345 3 None None None 152964643 Common - preprotein translocase, SecE subunit Krad_0674 9 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 152967981 Common - xylulokinase Krad_4038 116 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 152965550 Common - hypothetical protein Krad_1584 18 None None None 152964980 Common - zinc finger SWIM domain protein Krad_1012 39 COG4279 COG4279, Uncharacterized conserved protein Function unknown 152967629 Common - molybdenum cofactor synthesis domain Krad_3686 186 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 152964520 Common - regulatory protein GntR HTH Krad_0551 16 COG2186 FadR, Transcriptional regulators Transcription 152964455 Common - V-type H(+)-translocating pyrophosphatase Krad_0485 98 COG3808 OVP1, Inorganic pyrophosphatase Energy production and conversion 152964647 Common - ribosomal protein L10 Krad_0678 204 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 152967712 Common - RDD domain containing protein Krad_3769 7 COG1714 COG1714, Predicted membrane protein/domain Function unknown 152964599 Common - ResB family protein Krad_0630 18 COG1333 ResB, ResB protein required for cytochrome c biosynthesis Posttranslational modification, protein turnover, chaperones 152967765 Common - ABC transporter transmembrane region Krad_3822 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 152965796 Common - glycosyl transferase group 1 Krad_1830 5 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152964487 Common - protein of unknown function UPF0118 Krad_0518 102 COG0628 PerM, Predicted permease General function prediction only 152963997 Common - protein of unknown function UPF0233 Krad_0025 17 None None None 152968154 Common - transcriptional regulator, GntR family Krad_4211 98 COG1802 GntR, Transcriptional regulators Transcription 152965491 Common - major facilitator superfamily MFS_1 Krad_1523 115 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 152968220 Common - transcriptional regulator, MarR family Krad_4277 9 COG1846 MarR, Transcriptional regulators Transcription 152966837 Common - NADP oxidoreductase coenzyme F420-dependent Krad_2893 55 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 152963982 Common - AAA ATPase central domain protein Krad_0010 144 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 152967394 Common - glycosyl transferase family 2 Krad_3451 151 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152965164 Nonpathogen - hypothetical protein Krad_1196 1 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 152967633 Common - 5-formyltetrahydrofolate cyclo-ligase Krad_3690 29 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 152966386 Nonpathogen - hypothetical protein Krad_2426 1 None None None 152964014 Common - Multisubunit Na+/H+ antiporter MnhE subunit-like protein Krad_0043 19 COG1863 MnhE, Multisubunit Na+/H+ antiporter, MnhE subunit Inorganic ion transport and metabolism 152967503 Common - aminotransferase class V Krad_3560 237 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 152966302 Nonpathogen - hypothetical protein Krad_2342 1 None None None 152967842 Common - putative cell wall binding repeat 2-containing protein Krad_3899 7 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 152966189 Common - extracellular solute-binding protein family 1 Krad_2228 23 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152967517 Nonpathogen - hypothetical protein Krad_3574 5 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 152968121 Common - DNA binding domain, excisionase family Krad_4178 14 COG3585 MopI, Molybdopterin-binding protein Coenzyme metabolism 152967444 Common - periplasmic binding protein Krad_3501 28 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 152964284 Common - CheA signal transduction histidine kinase Krad_0314 152 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 152964334 Nonpathogen - Smr protein/MutS2 Krad_0364 5 None None None 152967036 Nonpathogen - hypothetical protein Krad_3092 1 None None None 152965223 Common - transcription termination factor Rho Krad_1255 207 COG1158 Rho, Transcription termination factor Transcription 152967005 Common - hypothetical protein Krad_3061 10 None None None 152964752 Common - protein of unknown function DUF156 Krad_0784 61 COG1937 COG1937, Uncharacterized protein conserved in bacteria Function unknown 152966317 Nonpathogen - hypothetical protein Krad_2357 1 None None None 152965321 Common - branched-chain amino acid aminotransferase Krad_1353 207 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 152966367 Nonpathogen - protein tyrosine/serine phosphatase Krad_2407 4 COG2365 COG2365, Protein tyrosine/serine phosphatase Signal transduction mechanisms 152966018 Nonpathogen - hypothetical protein Krad_2053 1 None None None 152967601 Common - protein of unknown function DUF485 Krad_3658 53 COG3162 COG3162, Predicted membrane protein Function unknown 152967778 Common - glycogen debranching enzyme GlgX Krad_3835 160 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 152967863 Common - purine nucleotide phosphorylase Krad_3920 111 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 152967550 Common - ATP-dependent DNA helicase Krad_3607 31 COG3973 COG3973, Superfamily I DNA and RNA helicases General function prediction only 152967454 Common - transcriptional regulator, MarR family Krad_3511 22 COG1846 MarR, Transcriptional regulators Transcription 152967663 Common - transcriptional regulator, TetR family Krad_3720 53 COG1309 AcrR, Transcriptional regulator Transcription 152965771 Common - amino acid permease-associated region Krad_1805 171 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 152968137 Common - short-chain dehydrogenase/reductase SDR Krad_4194 156 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 152967622 Common - glycosyl transferase group 1 Krad_3679 16 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152968063 Common - NAD/FAD-dependent oxidoreductase-like protein Krad_4120 23 COG3380 COG3380, Predicted NAD/FAD-dependent oxidoreductase General function prediction only 152966897 Common - ABC transporter-related protein Krad_2953 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 152968056 Common - diguanylate cyclase Krad_4113 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152965651 Common - ATPase associated with various cellular activities AAA_3 Krad_1685 172 COG0714 COG0714, MoxR-like ATPases General function prediction only 152965559 Common - amine oxidase Krad_1593 14 COG1231 COG1231, Monoamine oxidase Amino acid transport and metabolism 152965695 Nonpathogen - hypothetical protein Krad_1729 1 None None None 152964799 Common - response regulator receiver and ANTAR domain protein Krad_0831 13 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 152964619 Nonpathogen - hypothetical protein Krad_0650 1 None None None 152966095 Common - Alcohol dehydrogenase GroES domain protein Krad_2131 182 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 152965588 Common - flagellar hook-associated protein FlgK Krad_1622 122 COG1256 FlgK, Flagellar hook-associated protein Cell motility and secretion 152967478 Common - nitroreductase Krad_3535 63 COG0778 NfnB, Nitroreductase Energy production and conversion 152964256 Common - ribosomal protein L33 Krad_0286 129 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 152965260 Common - binding-protein-dependent transport systems inner membrane component Krad_1292 71 COG1174 OpuBB, ABC-type proline/glycine betaine transport systems, permease component Amino acid transport and metabolism 152967716 Common - hypothetical protein Krad_3773 19 None None None 152967809 Common - glycosyl transferase family 2 Krad_3866 203 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152965965 Common - putative ABC transporter transmembrane protein Krad_2000 7 None None None 152966899 Common - inner-membrane translocator Krad_2955 157 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 152964693 Common - glucosamine--fructose-6-phosphate aminotransferase, isomerizing Krad_0724 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 152965185 Common - methyl-accepting chemotaxis sensory transducer Krad_1217 63 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152967411 Common - binding-protein-dependent transport systems inner membrane component Krad_3468 161 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152967593 Common - uncharacterized conserved small protein-like protein Krad_3650 15 COG5515 COG5515, Uncharacterized conserved small protein Function unknown 152965813 Common - response regulator receiver modulated CheB methylesterase Krad_1847 222 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 152967040 Common - FHA domain containing protein Krad_3096 52 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 152968168 Common - transcriptional regulator, GntR family Krad_4225 83 COG1802 GntR, Transcriptional regulators Transcription 152965728 Common - parB-like partition protein Krad_1762 180 COG1475 Spo0J, Predicted transcriptional regulators Transcription 152964060 Nonpathogen - hypothetical protein Krad_0089 1 None None None 152967687 Common - putative transcriptional regulator, AsnC family Krad_3744 130 COG1522 Lrp, Transcriptional regulators Transcription 152965074 Common - undecaprenyl diphosphate synthase Krad_1106 241 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 152967995 Common - ABC transporter-related protein Krad_4052 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 152966451 Common - plasmid encoded RepA protein Krad_2495 12 None None None 152967020 Common - NUDIX hydrolase Krad_3076 26 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 152965537 Common - transcriptional regulator, TetR family Krad_1571 10 COG1309 AcrR, Transcriptional regulator Transcription 152965450 Common - cell divisionFtsK/SpoIIIE Krad_1482 198 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 152966174 Common - Alcohol dehydrogenase GroES domain protein Krad_2213 191 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 152968147 Common - short-chain dehydrogenase/reductase SDR Krad_4204 234 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152965437 Common - conserved hypothetical secreted protein Krad_1469 11 None None None 152968232 Nonpathogen - hypothetical protein Krad_4289 1 None None None 152966983 Nonpathogen - phosphoesterase PA-phosphatase related Krad_3039 1 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 152967813 Common - mannose-6-phosphate isomerase, class I Krad_3870 41 COG1482 ManA, Phosphomannose isomerase Carbohydrate transport and metabolism 152966596 Common - putative kinase Krad_2644 8 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 152966683 Nonpathogen - hypothetical protein Krad_2731 1 None None None 152964553 Nonpathogen - hypothetical protein Krad_0584 3 COG3458 COG3458, Acetyl esterase (deacetylase) Secondary metabolites biosynthesis, transport, and catabolism 152964468 Common - chromate transporter, chromate ion transporter (CHR) family Krad_0499 80 COG2059 ChrA, Chromate transport protein ChrA Inorganic ion transport and metabolism 152967818 Common - Protein of unknown function DUF1800 Krad_3875 47 COG5267 COG5267, Uncharacterized protein conserved in bacteria Function unknown 152966879 Common - excinuclease ABC, C subunit Krad_2935 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 152964682 Common - ribosomal protein S13 Krad_0713 224 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 152965445 Common - Xylose isomerase domain protein TIM barrel Krad_1477 33 COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins Amino acid transport and metabolism / General function prediction only 152966877 Common - protein of unknown function UPF0052 and CofD Krad_2933 87 COG0391 COG0391, Uncharacterized conserved protein Function unknown 152966346 Nonpathogen - hypothetical protein Krad_2386 1 None None None 152964925 Nonpathogen - hypothetical protein Krad_0957 1 None None None 152964949 Common - aminotransferase class V Krad_0981 120 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 152964603 Nonpathogen - hypothetical protein Krad_0634 1 None None None 152964228 Nonpathogen - hypothetical protein Krad_0258 1 None None None 152965297 Nonpathogen - hypothetical protein Krad_1329 6 None None None 152964765 Common - short-chain dehydrogenase/reductase SDR Krad_0797 70 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 152965094 Common - binding-protein-dependent transport systems inner membrane component Krad_1126 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 152964259 Common - hypothetical protein Krad_0289 2 None None None 152967428 Common - protein of unknown function DUF1684 Krad_3485 21 COG3358 COG3358, Uncharacterized conserved protein Function unknown 152964405 Common - putative transcriptional regulator, MerR family Krad_0435 74 COG0789 SoxR, Predicted transcriptional regulators Transcription 152965835 Common - ABC transporter-related protein Krad_1869 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 152966449 Common - amidohydrolase 2 Krad_2493 38 COG3618 COG3618, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 152966859 Common - FeS assembly ATPase SufC Krad_2915 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 152967338 Common - protein of unknown function DUF407 Krad_3394 112 COG2308 COG2308, Uncharacterized conserved protein Function unknown 152967948 Nonpathogen - hypothetical protein Krad_4005 1 None None None 152964498 Common - tRNA(Ile)-lysidine synthetase Krad_0529 95 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 152964954 Nonpathogen - hypothetical protein Krad_0986 1 None None None 152967045 Common - CDP-alcohol phosphatidyltransferase Krad_3101 84 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 152965292 Common - cobalamin (vitamin B12) biosynthesis CbiX protein Krad_1324 11 COG2138 COG2138, Uncharacterized conserved protein Function unknown 152966943 Nonpathogen - hypothetical protein Krad_2999 1 None None None 152966602 Nonpathogen - hypothetical protein Krad_2650 1 None None None 152966547 Common - transcriptional regulator, MarR family Krad_2593 90 COG1846 MarR, Transcriptional regulators Transcription 152966295 Nonpathogen - hypothetical protein Krad_2335 1 None None None 152966659 Nonpathogen - transcriptional regulator, TetR family Krad_2707 1 COG1309 AcrR, Transcriptional regulator Transcription 152964946 Common - hypothetical protein Krad_0978 14 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 152965176 Common - GTPase EngC Krad_1208 163 COG1162 COG1162, Predicted GTPases General function prediction only 152964939 Common - periplasmic binding protein/LacI transcriptional regulator Krad_0971 127 COG1609 PurR, Transcriptional regulators Transcription 152965622 Nonpathogen - flagellar hook-length control protein Krad_1656 1 COG3144 FliK, Flagellar hook-length control protein Cell motility and secretion 152967776 Common - protein of unknown function UPF0157 Krad_3833 11 COG2320 GrpB, Uncharacterized conserved protein Function unknown 152966353 Nonpathogen - hypothetical protein Krad_2393 1 None None None 152968202 Common - Endopeptidase Clp Krad_4259 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 152965913 Common - amidohydrolase Krad_1947 131 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 152965231 Nonpathogen - hypothetical protein Krad_1263 1 None None None 152965827 Common - hypothetical protein Krad_1861 55 COG0385 COG0385, Predicted Na+-dependent transporter General function prediction only 152967607 Nonpathogen - hypothetical protein Krad_3664 1 None None None 152966751 Common - integral membrane sensor signal transduction histidine kinase Krad_2801 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152965649 Common - transglutaminase domain protein Krad_1683 104 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 152964558 Common - extracellular solute-binding protein family 1 Krad_0589 43 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152964666 Common - ribosomal protein S17 Krad_0697 231 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 152965513 Nonpathogen - nitroreductase Krad_1547 3 COG0778 NfnB, Nitroreductase Energy production and conversion 152965767 Common - hypothetical protein Krad_1801 10 None None None 152964241 Common - hypothetical protein Krad_0271 15 None None None 152967122 Common - oxidoreductase domain protein Krad_3178 171 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152964616 Common - ubiquinone/menaquinone biosynthesis methyltransferase Krad_0647 215 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152964573 Nonpathogen - hypothetical protein Krad_0604 1 None None None 152966514 Nonpathogen - hypothetical protein Krad_2559 1 None None None 152967649 Common - putative lipase transmembrane protein Krad_3706 3 COG1647 COG1647, Esterase/lipase General function prediction only 152967977 Common - short-chain dehydrogenase/reductase SDR Krad_4034 131 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152966782 Nonpathogen - hypothetical protein Krad_2834 2 None None None 152964533 Nonpathogen - hypothetical protein Krad_0564 2 None None None 152965924 Common - dienelactone hydrolase Krad_1958 15 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 152966180 Nonpathogen - transcriptional regulator, MarR family Krad_2219 1 COG1846 MarR, Transcriptional regulators Transcription 152967345 Common - hypothetical protein Krad_3401 4 None None None 152965194 Common - AAA ATPase Krad_1226 28 COG3910 COG3910, Predicted ATPase General function prediction only 152967642 Common - Phosphoglycerate mutase Krad_3699 85 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 152967492 Nonpathogen - hypothetical protein Krad_3549 1 None None None 152966881 Common - amine oxidase Krad_2937 16 COG1232 HemY, Protoporphyrinogen oxidase Coenzyme metabolism 152968270 Common - protein of unknown function DUF81 Krad_4327 35 COG0730 COG0730, Predicted permeases General function prediction only 152965880 Common - methyl-accepting chemotaxis sensory transducer Krad_1914 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152964124 Nonpathogen - putative integral membrane protein Krad_0153 1 None None None 152965766 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_1800 133 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152967285 Nonpathogen - hypothetical protein Krad_3341 2 None None None 152965735 Common - DNA polymerase III, beta subunit Krad_1769 132 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 152967070 Nonpathogen - hypothetical protein Krad_3126 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 152967719 Common - diguanylate cyclase Krad_3776 176 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152965153 Common - protein of unknown function DUF45 Krad_1185 126 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 152967990 Common - Deoxyribodipyrimidine photolyase-like protein Krad_4047 99 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 152967301 Nonpathogen - hypothetical protein Krad_3357 1 None None None 152967138 Common - alanine racemase domain protein Krad_3194 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 152964117 Common - binding-protein-dependent transport systems inner membrane component Krad_0146 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 152964371 Common - putative PAS/PAC sensor protein Krad_0401 74 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152966168 Common - FAD linked oxidase domain protein Krad_2207 32 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 152966568 Common - hypothetical protein Krad_2615 24 None None None 152968316 Nonpathogen - hypothetical protein Krad_4373 1 None None None 152964512 Nonpathogen - secreted protein Krad_0543 1 None None None 152965701 Nonpathogen - hypothetical protein Krad_1735 1 None None None 152966652 Common - Alcohol dehydrogenase zinc-binding domain protein Krad_2700 203 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 152964874 Common - transcriptional regulator, TetR family Krad_0906 80 COG1309 AcrR, Transcriptional regulator Transcription 152967898 Common - succinate dehydrogenase and fumarate reductase iron-sulfur protein Krad_3955 208 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 152964770 Common - periplasmic binding protein/LacI transcriptional regulator Krad_0802 128 COG1609 PurR, Transcriptional regulators Transcription 152966797 Common - hypothetical protein Krad_2850 6 None None None 152964674 Common - ribosomal protein S5 Krad_0705 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 152964843 Common - phosphate ABC transporter, periplasmic phosphate-binding protein Krad_0875 102 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 152966709 Common - glutathionylspermidine synthase Krad_2757 53 COG0754 Gsp, Glutathionylspermidine synthase Amino acid transport and metabolism 152966991 Nonpathogen - hypothetical protein Krad_3047 1 None None None 152966259 Common - response regulator receiver modulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase Krad_2298 245 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 152964232 Common - short-chain dehydrogenase/reductase SDR Krad_0262 231 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152966922 Common - 3,4-dihydroxy-2-butanone 4-phosphate synthase Krad_2978 228 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 152964165 Common - TRAP dicarboxylate transporter, DctP subunit Krad_0194 96 COG1638 DctP, TRAP-type C4-dicarboxylate transport system, periplasmic component Carbohydrate transport and metabolism 152965869 Common - protein of unknown function DUF159 Krad_1903 102 COG2135 COG2135, Uncharacterized conserved protein Function unknown 152966665 Common - Alcohol dehydrogenase GroES domain protein Krad_2713 213 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 152966698 Common - ABC transporter-related protein Krad_2746 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 152968209 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Krad_4266 192 COG0388 COG0388, Predicted amidohydrolase General function prediction only 152967418 Common - Methionine synthase vitamin-B12 independent Krad_3475 57 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 152968093 Common - extracellular solute-binding protein family 3 Krad_4150 170 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 152965330 Common - Cys/Met metabolism pyridoxal-phosphate-dependent protein Krad_1362 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 152966438 Nonpathogen - hypothetical protein Krad_2482 1 None None None 152964891 Common - GCN5-related N-acetyltransferase Krad_0923 36 COG2388 COG2388, Predicted acetyltransferase General function prediction only 152966143 Nonpathogen - hypothetical protein Krad_2180 1 None None None 152966081 Common - transcriptional regulator, TetR family Krad_2116 98 COG1309 AcrR, Transcriptional regulator Transcription 152966417 Nonpathogen - hypothetical protein Krad_2461 1 None None None 152964993 Common - short-chain dehydrogenase/reductase SDR Krad_1025 236 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 152965805 Common - protein of unknown function DUF124 Krad_1839 25 COG2013 COG2013, Uncharacterized conserved protein Function unknown 152967726 Common - short-chain dehydrogenase/reductase SDR Krad_3783 87 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152967084 Common - NUDIX hydrolase Krad_3140 131 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 152964112 Nonpathogen - hypothetical protein Krad_0141 1 None None None 152966200 Nonpathogen - hypothetical protein Krad_2239 1 None None None 152964495 Common - Inorganic diphosphatase Krad_0526 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 152967651 Common - hypothetical protein Krad_3708 6 None None None 152964187 Common - GCN5-related N-acetyltransferase Krad_0216 88 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 152967264 Common - luciferase family protein Krad_3320 85 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152966002 Common - transcriptional regulator, TetR family Krad_2037 22 COG1309 AcrR, Transcriptional regulator Transcription 152965465 Common - extracellular solute-binding protein family 3 Krad_1497 172 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 152966065 Nonpathogen - hypothetical protein Krad_2100 1 None None None 152967175 Common - Peptidoglycan-binding LysM Krad_3231 99 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 152964077 Common - transcriptional regulator, GntR family Krad_0106 101 COG1802 GntR, Transcriptional regulators Transcription 152966009 Common - NmrA family protein Krad_2044 110 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152966817 Common - hypothetical protein Krad_2871 5 None None None 152964810 Nonpathogen - hypothetical protein Krad_0842 1 None None None 152967557 Common - Alcohol dehydrogenase zinc-binding domain protein Krad_3614 152 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 152964906 Nonpathogen - aminoglycoside phosphotransferase Krad_0938 3 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 152967783 Common - hypothetical protein Krad_3840 3 COG2835 COG2835, Uncharacterized conserved protein Function unknown 152966603 Common - transcriptional regulator, MarR family Krad_2651 17 COG1846 MarR, Transcriptional regulators Transcription 152964139 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Krad_0168 6 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152964806 Common - Putrescine oxidase Krad_0838 31 COG1231 COG1231, Monoamine oxidase Amino acid transport and metabolism 152967618 Nonpathogen - hypothetical protein Krad_3675 1 None None None 152964561 Nonpathogen - hypothetical protein Krad_0592 1 None None None 152968277 Common - MATE efflux family protein Krad_4334 61 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 152967547 Common - hypothetical protein Krad_3604 13 None None None 152967165 Common - alpha/beta hydrolase fold Krad_3221 11 COG2267 PldB, Lysophospholipase Lipid metabolism 152965987 Common - diguanylate cyclase/phosphodiesterase Krad_2022 174 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152966754 Common - putative transcriptional regulator, XRE family Krad_2804 41 COG1396 HipB, Predicted transcriptional regulators Transcription 152965572 Common - methyl-accepting chemotaxis sensory transducer Krad_1606 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152968078 Common - putative membrane protein (DUF990 family) Krad_4135 7 COG4587 COG4587, ABC-type uncharacterized transport system, permease component General function prediction only 152968264 Common - regulatory protein TetR Krad_4321 15 None None None 152966207 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_2246 48 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152965698 Nonpathogen - hypothetical protein Krad_1732 1 None None None 152967212 Common - Dihydroorotate oxidase Krad_3268 161 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 152963979 Common - DNA gyrase, A subunit Krad_0007 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 152967068 Common - protein of unknown function DUF909 Krad_3124 4 COG4842 COG4842, Uncharacterized protein conserved in bacteria Function unknown 152966785 Nonpathogen - hypothetical protein Krad_2837 1 None None None 152968437 Common - NLP/P60 protein Krad_4498 129 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 152968430 Nonpathogen - hypothetical protein Krad_4491 1 None None None 152967836 Common - GntR domain protein Krad_3893 19 COG2186 FadR, Transcriptional regulators Transcription 152965366 Common - ribosomal protein S16 Krad_1398 213 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 152964519 Common - Endo-1,4-beta-xylanase Krad_0550 33 COG3693 XynA, Beta-1,4-xylanase Carbohydrate transport and metabolism 152964158 Common - protein of unknown function DUF344 Krad_0187 127 COG2326 COG2326, Uncharacterized conserved protein Function unknown 152964711 Common - inosine-5'-monophosphate dehydrogenase Krad_0742 243 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 152968326 Common - protein of unknown function DUF165 Krad_4383 4 COG1738 COG1738, Uncharacterized conserved protein Function unknown 152964283 Common - protein of unknown function ATP binding Krad_0313 32 COG2229 COG2229, Predicted GTPase General function prediction only 152966013 Nonpathogen - hypothetical protein Krad_2048 2 None None None 152968425 Common - transcriptional regulator, MarR family Krad_4486 21 COG1846 MarR, Transcriptional regulators Transcription 152964735 Common - 1-aminocyclopropane-1-carboxylate deaminase Krad_0767 55 COG2515 Acd, 1-aminocyclopropane-1-carboxylate deaminase Amino acid transport and metabolism 152964397 Common - hypothetical protein Krad_0427 16 None None None 152964406 Common - Stage II sporulation E family protein Krad_0436 80 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152966342 Nonpathogen - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_2382 3 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152966625 Nonpathogen - hypothetical protein Krad_2673 1 None None None 152966395 Common - hypothetical protein Krad_2435 5 None None None 152967590 Common - permease for cytosine/purines uracil thiamine allantoin Krad_3647 24 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 152965419 Common - phage shock protein A, PspA Krad_1451 21 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 152964128 Nonpathogen - protein of unknown function UPF0016 Krad_0157 13 COG2119 COG2119, Predicted membrane protein Function unknown 152967206 Common - peptidase M20 Krad_3262 156 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 152966510 Common - ATPase-like protein Krad_2555 8 COG0433 COG0433, Predicted ATPase General function prediction only 152964867 Common - 4-diphosphocytidyl-2C-methyl-D-erythritol synthase Krad_0899 37 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 152964273 Common - extracellular solute-binding protein family 1 Krad_0303 86 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152964929 Common - luciferase family protein Krad_0961 23 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152967257 Nonpathogen - hypothetical protein Krad_3313 3 None None None 152966726 Common - 5'-Nucleotidase domain protein Krad_2776 68 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 152967540 Common - pyridoxamine 5'-phosphate oxidase Krad_3597 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 152967248 Common - hypothetical protein Krad_3304 11 None None None 152966504 Common - protein of unknown function UPF0187 Krad_2549 55 COG3781 COG3781, Predicted membrane protein Function unknown 152965148 Nonpathogen - hypothetical protein Krad_1180 1 None None None 152964922 Nonpathogen - hypothetical protein Krad_0954 1 None None None 152967964 Common - integral membrane sensor signal transduction histidine kinase Krad_4021 12 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152968105 Common - deoxyribose-phosphate aldolase Krad_4162 90 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 152967541 Nonpathogen - protein of unknown function DUF218 Krad_3598 2 COG1434 COG1434, Uncharacterized conserved protein Function unknown 152964052 Nonpathogen - hypothetical protein Krad_0081 1 None None None 152964447 Common - type II secretion system protein E Krad_0477 143 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 152966237 Nonpathogen - hypothetical protein Krad_2276 1 None None None 152967145 Common - UDP-N-acetylmuramoylalanine--D-glutamate ligase Krad_3201 210 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 152965064 Nonpathogen - hypothetical protein Krad_1096 4 None None None 152964339 Common - diguanylate cyclase/phosphodiesterase Krad_0369 177 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152966403 Common - diguanylate cyclase/phosphodiesterase Krad_2444 182 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152966605 Common - Extradiol ring-cleavage dioxygenase class III protein subunit B Krad_2653 86 COG3384 COG3384, Uncharacterized conserved protein Function unknown 152965328 Common - histone family protein DNA-binding protein Krad_1360 204 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 152965361 Common - ammonium transporter Krad_1393 199 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 152967289 Common - phosphopantetheine-binding Krad_3345 198 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152965769 Common - diguanylate phosphodiesterase Krad_1803 157 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152964824 Common - acetate kinase Krad_0856 161 COG0282 ackA, Acetate kinase Energy production and conversion 152964465 Common - GCN5-related N-acetyltransferase Krad_0496 29 COG0456 RimI, Acetyltransferases General function prediction only 152965162 Common - Methyltransferase type 12 Krad_1194 14 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 152966177 Common - short-chain dehydrogenase/reductase SDR Krad_2216 211 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152965717 Nonpathogen - hypothetical protein Krad_1751 1 None None None 152967529 Common - diguanylate cyclase/phosphodiesterase Krad_3586 175 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152968041 Common - hypothetical protein Krad_4098 6 None None None 152964080 Common - 2-methylcitrate synthase/citrate synthase II Krad_0109 192 COG0372 GltA, Citrate synthase Energy production and conversion 152964917 Common - UspA domain protein Krad_0949 13 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 152966595 Nonpathogen - hypothetical protein Krad_2643 1 None None None 152964857 Common - hypothetical protein Krad_0889 14 None None None 152967272 Common - Arsenical pump membrane protein Krad_3328 41 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 152966556 Nonpathogen - hypothetical protein Krad_2603 1 None None None 152966198 Common - hypothetical protein Krad_2237 17 None None None 152965928 Nonpathogen - hypothetical protein Krad_1962 1 None None None 152967972 Common - transcriptional regulator, TetR family Krad_4029 53 COG1309 AcrR, Transcriptional regulator Transcription 152966413 Common - diguanylate cyclase Krad_2455 182 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152965254 Common - periplasmic binding protein/LacI transcriptional regulator Krad_1286 122 COG1609 PurR, Transcriptional regulators Transcription 152965174 Common - histidinol-phosphate phosphatase, putative Krad_1206 187 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 152968367 Common - diguanylate cyclase with PAS/PAC sensor Krad_4428 180 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152964071 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_0100 17 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152967029 Common - hypothetical protein Krad_3085 12 COG4329 COG4329, Predicted membrane protein Function unknown 152966029 Common - monoxygenase Krad_2064 66 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152967220 Common - Leucyl aminopeptidase Krad_3276 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 152965996 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Krad_2031 5 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152965647 Common - AMP-dependent synthetase and ligase Krad_1681 36 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152966119 Common - transcriptional regulator, DeoR family Krad_2155 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 152965311 Nonpathogen - hypothetical protein Krad_1343 3 None None None 152967509 Common - extracellular solute-binding protein family 1 Krad_3566 40 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152964819 Nonpathogen - hypothetical protein Krad_0851 1 None None None 152963988 Common - glycosyl transferase group 1 Krad_0016 180 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152967379 Common - glycoside hydrolase family 3 domain protein Krad_3436 119 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 152966954 Nonpathogen - hypothetical protein Krad_3010 1 None None None 152965686 Nonpathogen - hypothetical protein Krad_1720 1 None None None 152967954 Common - protein of unknown function DUF427 Krad_4011 31 COG2343 COG2343, Uncharacterized protein conserved in bacteria Function unknown 152965837 Common - protein of unknown function DUF245 domain protein Krad_1871 15 None None None 152967181 Nonpathogen - Endonuclease/exonuclease/phosphatase Krad_3237 1 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 152968028 Common - alanine dehydrogenase Krad_4085 166 COG0686 Ald, Alanine dehydrogenase Amino acid transport and metabolism 152966256 Common - Cupin 2 conserved barrel domain protein Krad_2295 16 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 152967292 Nonpathogen - hypothetical protein Krad_3348 2 None None None 152965242 Common - anti-sigma-factor antagonist Krad_1274 17 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 152968375 Common - DSBA oxidoreductase Krad_4436 80 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 152967325 Common - aldo/keto reductase Krad_3381 198 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152964909 Common - binding-protein-dependent transport systems inner membrane component Krad_0941 219 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 152968249 Common - hypothetical protein Krad_4306 5 COG2339 COG2339, Predicted membrane protein Function unknown 152966247 Common - regulatory protein LuxR Krad_2286 53 COG3899 COG3899, Predicted ATPase General function prediction only 152964262 Common - YibE/F family protein Krad_0292 18 COG5438 COG5438, Predicted multitransmembrane protein Function unknown 152967564 Common - integral membrane sensor signal transduction histidine kinase Krad_3621 204 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152968406 Common - hypothetical protein Krad_4467 20 COG3662 COG3662, Uncharacterized protein conserved in bacteria Function unknown 152967144 Common - cell division protein FtsW Krad_3200 165 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 152965744 Common - transcriptional regulator, XRE family Krad_1778 4 COG1396 HipB, Predicted transcriptional regulators Transcription 152964774 Common - Ribonucleoside-diphosphate reductase Krad_0806 148 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 152968346 Common - ATP-dependent nuclease subunit B-like protein Krad_4407 10 COG3857 AddB, ATP-dependent nuclease, subunit B DNA replication, recombination, and repair 152968097 Common - DNA primase small subunit Krad_4154 66 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 152967241 Common - NAD+ synthetase Krad_3297 219 COG0171 NadE, NAD synthase Coenzyme metabolism 152965970 Common - histone family protein DNA-binding protein Krad_2005 206 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 152968242 Common - Platelet-activating factor acetylhydrolase plasma/intracellular isoform II Krad_4299 6 COG4188 COG4188, Predicted dienelactone hydrolase General function prediction only 152964910 Common - ABC transporter-related protein Krad_0942 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 152964417 Common - peptidase S9 prolyl oligopeptidase active site domain protein Krad_0447 97 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 152968307 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Krad_4364 169 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152965056 Nonpathogen - hypothetical protein Krad_1088 1 None None None 152966519 Nonpathogen - hypothetical protein Krad_2564 2 None None None 152967668 Common - luciferase family protein Krad_3725 18 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152964420 Common - GCN5-related N-acetyltransferase Krad_0450 61 COG0456 RimI, Acetyltransferases General function prediction only 152964759 Common - aryldialkylphosphatase Krad_0791 24 COG1735 Php, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 152965548 Common - 3'-5' exonuclease Krad_1582 87 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 152966129 Common - sugar ABC transporter Krad_2165 139 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152967316 Common - Phosphoenolpyruvate carboxylase Krad_3372 116 COG2352 Ppc, Phosphoenolpyruvate carboxylase Energy production and conversion 152964200 Common - short-chain dehydrogenase/reductase SDR Krad_0229 233 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152966156 Nonpathogen - GCN5-related N-acetyltransferase Krad_2193 1 COG0456 RimI, Acetyltransferases General function prediction only 152968287 Common - molybdopterin oxidoreductase Krad_4344 154 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 152967743 Common - hypothetical protein Krad_3800 63 COG3343 RpoE, DNA-directed RNA polymerase, delta subunit Transcription 152965390 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Krad_1422 8 COG3871 COG3871, Uncharacterized stress protein (general stress protein 26) General function prediction only 152965710 Nonpathogen - hypothetical protein Krad_1744 1 None None None 152968185 Nonpathogen - hypothetical protein Krad_4242 1 None None None 152968436 Common - integral membrane protein MviN Krad_4497 106 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 152966736 Nonpathogen - hypothetical protein Krad_2786 1 None None None 152964837 Nonpathogen - hypothetical protein Krad_0869 1 None None None 152965758 Common - transcriptional regulator, XRE family Krad_1792 5 COG1476 COG1476, Predicted transcriptional regulators Transcription 152966120 Common - hypothetical protein Krad_2156 5 None None None 152964997 Common - diguanylate cyclase/phosphodiesterase Krad_1029 168 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152964032 Common - Pyridoxal-5'-phosphate-dependent protein beta subunit Krad_0061 185 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 152966497 Nonpathogen - hypothetical protein Krad_2542 1 None None None 152964010 Nonpathogen - hypothetical protein Krad_0038 4 None None None 152965381 Common - transcriptional regulator, TraR/DksA family Krad_1413 61 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 152967572 Common - conserved hypothetical protein; putative SAM domain Krad_3629 81 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 152966051 Common - carbohydrate kinase FGGY Krad_2086 182 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 152965531 Nonpathogen - hypothetical protein Krad_1565 1 None None None 152964207 Common - ABC-3 protein Krad_0237 21 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 152965302 Common - dihydroxy-acid dehydratase Krad_1334 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 152965959 Common - integral membrane sensor signal transduction histidine kinase Krad_1993 17 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152964567 Common - Class I peptide chain release factor Krad_0598 34 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 152965613 Common - flagellar basal-body rod protein FlgB Krad_1647 18 COG1815 FlgB, Flagellar basal body protein Cell motility and secretion 152965524 Common - hypothetical protein Krad_1558 15 None None None 152968280 Common - ribosomal protein S18 Krad_4337 215 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 152965960 Common - hypothetical protein Krad_1995 19 None None None 152967690 Common - trehalose synthase Krad_3747 10 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 152966719 Nonpathogen - hypothetical protein Krad_2768 3 COG4325 COG4325, Predicted membrane protein Function unknown 152964485 Common - signal transduction histidine kinase regulating citrate/malate metabolism Krad_0516 154 COG3290 CitA, Signal transduction histidine kinase regulating citrate/malate metabolism Signal transduction mechanisms 152964292 Common - Protein-glutamate O-methyltransferase Krad_0322 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 152965395 Common - 1-deoxy-D-xylulose 5-phosphate reductoisomerase Krad_1427 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 152964368 Common - VanW family protein Krad_0398 35 COG2720 COG2720, Uncharacterized vancomycin resistance protein Defense mechanisms 152968192 Common - major facilitator superfamily MFS_1 Krad_4249 27 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152967705 Common - non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family Krad_3762 235 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 152968114 Common - oxidoreductase domain protein Krad_4171 106 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152964627 Common - Electron transfer flavoprotein alpha subunit Krad_0658 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 152966919 Common - ATP phosphoribosyltransferase Krad_2975 212 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 152965210 Common - DEAD/DEAH box helicase domain protein Krad_1242 226 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 152964366 Common - ABC transporter ATP-binding protein Krad_0396 91 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 152966572 Common - transcriptional regulator, TetR family Krad_2619 8 COG1309 AcrR, Transcriptional regulator Transcription 152965870 Common - drug resistance transporter, Bcr/CflA subfamily Krad_1904 133 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152965249 Common - hypothetical protein Krad_1281 4 None None None 152965046 Common - hypothetical protein Krad_1078 7 None None None 152967879 Common - GCN5-related N-acetyltransferase Krad_3936 117 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 152964001 Nonpathogen - hypothetical protein Krad_0029 1 None None None 152965276 Common - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Krad_1308 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 152965294 Common - uroporphyrin-III C-methyltransferase Krad_1326 200 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 152965820 Common - methyl-accepting chemotaxis sensory transducer Krad_1854 148 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152965213 Common - phosphoribosyltransferase Krad_1245 35 COG2236 COG2236, Predicted phosphoribosyltransferases General function prediction only 152966731 Common - Patatin Krad_2781 56 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 152967761 Common - hypothetical protein Krad_3818 10 None None None 152964944 Common - oxidoreductase domain protein Krad_0976 134 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152964834 Common - ferric uptake regulator, Fur family Krad_0866 38 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 152966949 Common - aspartate carbamoyltransferase Krad_3005 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 152968079 Common - protein of unknown function DUF990 Krad_4136 19 COG3694 COG3694, ABC-type uncharacterized transport system, permease component General function prediction only 152966534 Common - helix-turn-helix domain protein Krad_2579 41 None None None 152966768 Common - hypothetical protein Krad_2818 3 None None None 152967164 Common - YbaK/prolyl-tRNA synthetase associated region Krad_3220 25 COG2606 EbsC, Uncharacterized conserved protein Function unknown 152966773 Nonpathogen - hypothetical protein Krad_2825 1 None None None 152964563 Common - oxidoreductase domain protein Krad_0594 5 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152967135 Common - DivIVA family protein Krad_3191 16 COG4982 COG4982, 3-oxoacyl- acyl-carrier protein 152966425 Nonpathogen - hypothetical protein Krad_2469 1 None None None 152967729 Common - hypothetical protein Krad_3786 8 None None None 152964900 Common - putative monooxygenase Krad_0932 49 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152967373 Common - oxidoreductase domain protein Krad_3430 63 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152964327 Common - putative cell wall binding repeat 2-containing protein Krad_0357 11 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 152964527 Nonpathogen - hypothetical protein Krad_0558 4 None None None 152965454 Common - CinA domain protein Krad_1486 17 COG1546 CinA, Uncharacterized protein (competence- and mitomycin-induced) General function prediction only 152966075 Nonpathogen - hypothetical protein Krad_2110 3 COG5401 COG5401, Spore germination protein General function prediction only 152967027 Common - hypothetical protein Krad_3083 61 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 152968210 Common - dihydropyrimidinase Krad_4267 189 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 152967056 Common - binding-protein-dependent transport systems inner membrane component Krad_3112 145 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 152965599 Common - regulatory protein GntR HTH Krad_1633 105 COG2186 FadR, Transcriptional regulators Transcription 152965683 Nonpathogen - hypothetical protein Krad_1717 1 None None None 152965789 Common - cytidyltransferase-related domain Krad_1823 25 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 152966109 Common - transcriptional regulator, GntR family Krad_2145 117 COG1802 GntR, Transcriptional regulators Transcription 152965287 Common - glutamyl-tRNA(Gln) amidotransferase, B subunit Krad_1319 211 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 152964092 Nonpathogen - putative PAS/PAC sensor protein Krad_0121 4 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152967816 Common - short-chain dehydrogenase/reductase SDR Krad_3873 103 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152965967 Nonpathogen - hypothetical protein Krad_2002 1 None None None 152967802 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Krad_3859 249 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 152968344 Common - ABC transporter-related protein Krad_4405 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 152965423 Common - Alcohol dehydrogenase GroES domain protein Krad_1455 203 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 152967708 Common - hypothetical protein Krad_3765 14 None None None 152967892 Common - basic membrane lipoprotein Krad_3949 96 COG1744 Med, Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein General function prediction only 152965470 Common - methyltransferase small Krad_1502 42 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 152967578 Common - bifunctional deaminase-reductase domain protein Krad_3635 41 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 152966243 Nonpathogen - hypothetical protein Krad_2282 1 None None None 152965931 Common - LGFP repeat protein Krad_1965 13 COG5479 COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis Cell envelope biogenesis, outer membrane 152965705 Nonpathogen - hypothetical protein Krad_1739 1 None None None 152964181 Common - putative transcriptional regulator, MerR family Krad_0210 18 COG0789 SoxR, Predicted transcriptional regulators Transcription 152966747 Nonpathogen - glycosyl transferase group 1 Krad_2797 12 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152967946 Nonpathogen - hypothetical protein Krad_4003 2 None None None 152967030 Nonpathogen - hypothetical protein Krad_3086 1 COG3336 COG3336, Predicted membrane protein Function unknown 152968321 Nonpathogen - hypothetical protein Krad_4378 9 None None None 152967280 Common - protein of unknown function DUF34 Krad_3336 66 COG0327 COG0327, Uncharacterized conserved protein Function unknown 152965443 Nonpathogen - protein of unknown function DUF1469 Krad_1475 1 None None None 152967013 Common - sporulation and cell division protein SsgA Krad_3069 8 None None None 152966618 Nonpathogen - putative signal transduction histidine kinase Krad_2666 2 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152966843 Nonpathogen - hypothetical protein Krad_2899 1 None None None 152967644 Nonpathogen - hypothetical protein Krad_3701 1 None None None 152964583 Common - HAD-superfamily subfamily IB hydrolase, TIGR01490 Krad_0614 74 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 152965090 Common - exodeoxyribonuclease VII, large subunit Krad_1122 203 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 152966356 Common - Integrase catalytic region Krad_2396 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 152967483 Common - Palmitoyl-CoA hydrolase Krad_3540 77 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 152968279 Common - ribosomal protein L9 Krad_4336 210 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 152968351 Nonpathogen - hypothetical protein Krad_4412 2 None None None 152965120 Nonpathogen - hypothetical protein Krad_1152 3 None None None 152965855 Common - Amidohydrolase 3 Krad_1889 77 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 152965030 Common - glycosyl transferase group 1 Krad_1062 224 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152966267 Common - alpha/beta hydrolase fold Krad_2306 45 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152964501 Common - Carbamoyl-phosphate synthase L chain ATP-binding Krad_0532 230 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 152965169 Common - GCN5-related N-acetyltransferase Krad_1201 14 COG3153 COG3153, Predicted acetyltransferase General function prediction only 152967110 Common - tRNA/rRNA methyltransferase (SpoU) Krad_3166 81 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 152968002 Common - PfkB domain protein Krad_4059 61 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 152965782 Common - hypothetical protein Krad_1816 11 None None None 152965003 Common - DNA/RNA non-specific endonuclease Krad_1035 26 COG1864 NUC1, DNA/RNA endonuclease G, NUC1 Nucleotide transport and metabolism 152964476 Common - Methyltransferase type 12 Krad_0507 11 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152966968 Common - secretory protein Krad_3024 34 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 152966214 Nonpathogen - hypothetical protein Krad_2253 1 None None None 152965829 Common - putative esterase Krad_1863 15 COG0657 Aes, Esterase/lipase Lipid metabolism 152965661 Nonpathogen - hypothetical protein Krad_1695 1 None None None 152966223 Nonpathogen - hypothetical protein Krad_2262 1 None None None 152964155 Common - major facilitator superfamily MFS_1 Krad_0184 9 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 152965309 Common - flavodoxin/nitric oxide synthase Krad_1341 94 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 152964609 Nonpathogen - hypothetical protein Krad_0640 1 None None None 152966058 Common - ABC transporter-related protein Krad_2093 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 152967881 Common - transcriptional regulator, LysR family Krad_3938 24 COG0583 LysR, Transcriptional regulator Transcription 152967205 Common - iron-sulfur cluster assembly accessory protein Krad_3261 165 COG0316 IscA, Uncharacterized conserved protein Function unknown 152967434 Common - helix-turn-helix- domain containing protein AraC type Krad_3491 16 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 152965234 Common - ATP synthase F0, B subunit Krad_1266 21 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 152968445 Common - parB-like partition protein Krad_4506 184 COG1475 Spo0J, Predicted transcriptional regulators Transcription 152965139 Common - UvrD/REP helicase Krad_1171 22 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 152965387 Common - phosphatidate cytidylyltransferase Krad_1419 213 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 152964045 Common - cell cycle protein Krad_0074 193 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 152966761 Nonpathogen - hypothetical protein Krad_2811 1 None None None 152965630 Common - flagellar motor switch protein FliN Krad_1664 121 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 152968389 Common - imidazolonepropionase Krad_4450 99 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 152968060 Common - alpha amylase catalytic region Krad_4117 151 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 152967266 Nonpathogen - hypothetical protein Krad_3322 1 None None None 152965251 Common - ABC transporter-related protein Krad_1283 210 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 152965639 Common - flagellar biosynthesis protein FlhA Krad_1673 127 COG1298 FlhA, Flagellar biosynthesis pathway, component FlhA Cell motility and secretion / Intracellular trafficking and secretion 152964435 Common - recombination protein RecR Krad_0465 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 152966562 Common - Enoyl-CoA hydratase/isomerase Krad_2609 178 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 152964423 Nonpathogen - hypothetical protein Krad_0453 1 None None None 152965503 Common - transcriptional regulator, DeoR family Krad_1535 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 152965819 Common - response regulator receiver protein Krad_1853 224 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 152964215 Common - Prephenate dehydratase Krad_0245 201 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 152966372 Nonpathogen - hypothetical protein Krad_2412 1 None None None 152966688 Nonpathogen - Antibiotic biosynthesis monooxygenase Krad_2736 1 COG1359 COG1359, Uncharacterized conserved protein Function unknown 152966274 Common - hypothetical protein Krad_2313 3 None None None 152968259 Common - DNA ligase I, ATP-dependent Dnl1 Krad_4316 99 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 152965500 Common - hypothetical protein Krad_1532 7 COG2839 COG2839, Uncharacterized protein conserved in bacteria Function unknown 152966437 Common - secreted protein Krad_2481 9 COG3868 COG3868, Uncharacterized conserved protein Function unknown 152965879 Common - methyl-accepting chemotaxis sensory transducer Krad_1913 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152967799 Common - transcriptional regulator, LysR family Krad_3856 80 COG0583 LysR, Transcriptional regulator Transcription 152968297 Common - major facilitator superfamily MFS_1 Krad_4354 133 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152967860 Nonpathogen - hypothetical protein Krad_3917 1 None None None 152965921 Common - acetyltransferase-like protein Krad_1955 44 COG2388 COG2388, Predicted acetyltransferase General function prediction only 152968145 Common - transcriptional regulator, AraC family Krad_4202 68 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 152966315 Common - transcriptional regulator, MarR family Krad_2355 3 COG1846 MarR, Transcriptional regulators Transcription 152968058 Common - transcriptional regulator, TetR family Krad_4115 69 COG1309 AcrR, Transcriptional regulator Transcription 152965117 Common - Leucyl aminopeptidase Krad_1149 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 152965428 Common - short-chain dehydrogenase/reductase SDR Krad_1460 235 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 152964680 Common - translation initiation factor IF-1 Krad_0711 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 152967306 Common - O-acetylhomoserine/O-acetylserine sulfhydrylase Krad_3362 206 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 152964605 Common - hypothetical protein Krad_0636 3 None None None 152967811 Common - hypothetical protein Krad_3868 14 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152966384 Common - hypothetical protein Krad_2424 4 None None None 152967584 Common - short-chain dehydrogenase/reductase SDR Krad_3641 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152964803 Common - Urease Krad_0835 96 COG0804 UreC, Urea amidohydrolase (urease) alpha subunit Amino acid transport and metabolism 152965063 Common - methylmalonate-semialdehyde dehydrogenase Krad_1095 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 152966300 Nonpathogen - hypothetical protein Krad_2340 1 None None None 152967038 Common - protein of unknown function DUF151 Krad_3094 76 COG1259 COG1259, Uncharacterized conserved protein Function unknown 152968065 Common - Stage II sporulation E family protein Krad_4122 30 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152967446 Common - 3-hydroxyacyl-CoA dehydrogenase NAD-binding Krad_3503 156 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 152964872 Common - Urea carboxylase Krad_0904 227 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 152964543 Common - NADP oxidoreductase coenzyme F420-dependent Krad_0574 32 COG5495 COG5495, Uncharacterized conserved protein Function unknown 152968230 Common - Transketolase central region Krad_4287 189 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 152965248 Common - protein of unknown function DUF77 Krad_1280 21 COG0011 COG0011, Uncharacterized conserved protein Function unknown 152966681 Common - regulatory protein LuxR Krad_2729 53 COG3899 COG3899, Predicted ATPase General function prediction only 152967242 Common - 3-methyl-2-oxobutanoate hydroxymethyltransferase Krad_3298 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 152965778 Nonpathogen - hypothetical protein Krad_1812 1 None None None 152966221 Common - hypothetical protein Krad_2260 11 None None None 152966824 Nonpathogen - putative transcriptional regulator, PaaX family Krad_2878 1 COG3327 PaaX, Phenylacetic acid-responsive transcriptional repressor Transcription 152966450 Common - GCN5-related N-acetyltransferase Krad_2494 14 COG3393 COG3393, Predicted acetyltransferase General function prediction only 152965527 Common - TrkA-N domain protein Krad_1561 152 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 152967714 Common - hypothetical protein Krad_3771 9 COG4276 COG4276, Uncharacterized conserved protein Function unknown 152967568 Common - molybdenum cofactor biosynthesis protein A Krad_3625 194 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 152968088 Common - binding-protein-dependent transport systems inner membrane component Krad_4145 146 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152964388 Common - alpha/beta hydrolase fold Krad_0418 81 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152966872 Common - preprotein translocase, SecG subunit Krad_2928 3 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 152968260 Nonpathogen - hypothetical protein Krad_4317 2 None None None 152967377 Common - DNA internalization-related competence protein ComEC/Rec2 Krad_3434 97 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 152964161 Common - hypothetical protein Krad_0190 7 None None None 152968336 Nonpathogen - hypothetical protein Krad_4397 2 None None None 152967431 Common - acetate--CoA ligase Krad_3488 218 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 152968387 Common - methyltransferase FkbM family Krad_4448 18 None None None 152967082 Common - Cobyrinic acid ac-diamide synthase Krad_3138 227 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 152964336 Common - glutathione S-transferase-like protein Krad_0366 79 COG0435 ECM4, Predicted glutathione S-transferase Posttranslational modification, protein turnover, chaperones 152966309 Common - protein of unknown function UPF0157 Krad_2349 42 COG2320 GrpB, Uncharacterized conserved protein Function unknown 152968156 Common - putative GAF sensor protein Krad_4213 13 COG2203 FhlA, FOG: GAF domain Signal transduction mechanisms 152967456 Common - drug resistance transporter, EmrB/QacA subfamily Krad_3513 188 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152964982 Common - sugar transporter Krad_1014 121 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152964741 Common - amino acid permease-associated region Krad_0773 43 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 152964614 Nonpathogen - hypothetical protein Krad_0645 1 None None None 152964062 Common - Lycopene beta and epsilon cyclase Krad_0091 14 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 152968290 Common - protein serine phosphatase with GAF(s) sensor(s) Krad_4347 92 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152964710 Nonpathogen - hypothetical protein Krad_0741 1 COG5373 COG5373, Predicted membrane protein Function unknown 152967988 Common - L-serine dehydratase 1 Krad_4045 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 152966344 Nonpathogen - hypothetical protein Krad_2384 1 None None None 152964239 Nonpathogen - hypothetical protein Krad_0269 1 COG4907 COG4907, Predicted membrane protein Function unknown 152966455 Common - major facilitator superfamily MFS_1 Krad_2499 144 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 152964016 Common - NADH-ubiquinone oxidoreductase chain 4L Krad_0045 27 COG1006 MnhC, Multisubunit Na+/H+ antiporter, MnhC subunit Inorganic ion transport and metabolism 152966540 Nonpathogen - hypothetical protein Krad_2586 1 None None None 152964927 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Krad_0959 20 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 152966890 Common - putative sugar ABC transporter Krad_2946 73 COG4213 XylF, ABC-type xylose transport system, periplasmic component Carbohydrate transport and metabolism 152966980 Common - two component transcriptional regulator, winged helix family Krad_3036 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152967991 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_4048 56 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152965725 Common - hypothetical protein Krad_1759 6 None None None 152964166 Common - Tripartite ATP-independent periplasmic transporter DctQ component Krad_0195 44 COG3090 DctM, TRAP-type C4-dicarboxylate transport system, small permease component Carbohydrate transport and metabolism 152966435 Common - transcriptional regulator, TetR family Krad_2479 39 COG1309 AcrR, Transcriptional regulator Transcription 152965107 Common - aminotransferase class I and II Krad_1139 177 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 152964189 Common - putative cold-shock DNA-binding domain protein Krad_0218 181 COG1278 CspC, Cold shock proteins Transcription 152966819 Nonpathogen - hypothetical protein Krad_2873 2 None None None 152966985 Nonpathogen - Roadblock/LC7 family protein Krad_3041 3 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 152964655 Nonpathogen - hypothetical protein Krad_0686 1 None None None 152967887 Common - pyrimidine-nucleoside phosphorylase Krad_3944 119 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 152964555 Common - oxidoreductase domain protein Krad_0586 185 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152968179 Common - ABC transporter-related protein Krad_4236 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 152964346 Common - putative PAS/PAC sensor protein Krad_0376 106 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152968029 Common - putative transcriptional regulator, AsnC family Krad_4086 158 COG1522 Lrp, Transcriptional regulators Transcription 152968123 Common - SNARE associated Golgi protein Krad_4180 163 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 152965808 Common - protein of unknown function DUF75 Krad_1842 21 COG1938 COG1938, Archaeal enzymes of ATP-grasp superfamily General function prediction only 152965226 Common - beta-lactamase Krad_1258 38 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 152966039 Common - molybdopterin dehydrogenase FAD-binding Krad_2074 51 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 152967128 Nonpathogen - hypothetical protein Krad_3184 1 None None None 152964739 Common - Glutamine--fructose-6-phosphate transaminase (isomerizing) Krad_0771 233 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 152967007 Common - lipid A biosynthesis acyltransferase Krad_3063 12 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 152964247 Common - two component transcriptional regulator, LuxR family Krad_0277 173 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152964466 Nonpathogen - hypothetical protein Krad_0497 1 None None None 152964254 Common - 50S ribosomal protein L36 Krad_0284 37 None None None 152965452 Common - MiaB-like tRNA modifying enzyme YliG Krad_1484 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 152965495 Nonpathogen - hypothetical protein Krad_1527 1 None None None 152965081 Common - extracellular solute-binding protein family 1 Krad_1113 75 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152965894 Nonpathogen - hypothetical protein Krad_1928 1 None None None 152966639 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Krad_2687 6 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 152967519 Common - major facilitator superfamily MFS_1 Krad_3576 62 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152965915 Common - transcriptional regulator, XRE family Krad_1949 41 COG1396 HipB, Predicted transcriptional regulators Transcription 152964698 Common - protein of unknown function UPF0079 Krad_0729 186 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 152966579 Common - Helix-turn-helix type 11 domain protein Krad_2627 18 COG2378 COG2378, Predicted transcriptional regulator Transcription 152967520 Common - transcriptional regulator, LysR family Krad_3577 177 COG0583 LysR, Transcriptional regulator Transcription 152965563 Nonpathogen - hypothetical protein Krad_1597 1 None None None 152968356 Common - short-chain dehydrogenase/reductase SDR Krad_4417 143 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152965187 Common - MOSC domain containing protein Krad_1219 25 COG3217 COG3217, Uncharacterized Fe-S protein General function prediction only 152966053 Common - transcriptional regulator, DeoR family Krad_2088 58 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 152967938 Common - phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Krad_3995 218 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 152966370 Nonpathogen - hypothetical protein Krad_2410 1 None None None 152964920 Common - protein of unknown function DUF1486 Krad_0952 32 COG5485 COG5485, Predicted ester cyclase General function prediction only 152967392 Common - iojap-like protein Krad_3449 42 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 152965493 Common - SNARE associated Golgi protein Krad_1525 113 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 152965430 Nonpathogen - hypothetical protein Krad_1462 2 None None None 152967670 Common - Monosaccharide-transporting ATPase Krad_3727 111 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 152965872 Nonpathogen - hypothetical protein Krad_1906 1 None None None 152965278 Common - TAP domain protein Krad_1310 24 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152966442 Common - type III effector Hrp-dependent outers Krad_2486 57 COG3395 COG3395, Uncharacterized protein conserved in bacteria Function unknown 152967512 Common - Alpha-L-fucosidase Krad_3569 32 COG3669 COG3669, Alpha-L-fucosidase Carbohydrate transport and metabolism 152964645 Common - ribosomal protein L11 Krad_0676 248 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 152964972 Common - short-chain dehydrogenase/reductase SDR Krad_1004 233 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152965570 Common - Polysulphide reductase NrfD Krad_1604 7 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 152966812 Common - methylated-DNA--protein-cysteine methyltransferase Krad_2866 205 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 152964592 Common - helix-turn-helix- domain containing protein AraC type Krad_0623 111 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 152966632 Nonpathogen - hypothetical protein Krad_2680 1 None None None 152966219 Common - hypothetical protein Krad_2258 14 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 152964274 Common - transcriptional regulator, DeoR family Krad_0304 63 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 152967822 Common - SpoIID/LytB domain Krad_3879 49 COG2385 SpoIID, Sporulation protein and related proteins Cell division and chromosome partitioning 152964649 Common - DNA-directed RNA polymerase, beta subunit Krad_0680 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 152968237 Common - hypothetical protein Krad_4294 21 None None None 152967710 Common - putative nicotinate phosphoribosyltransferase Krad_3767 102 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 152966835 Common - signal peptidase I Krad_2890 158 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 152964728 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Krad_0759 11 None None None 152966588 Nonpathogen - hypothetical protein Krad_2636 1 None None None 152966646 Common - putative secreted protein Krad_2694 7 COG3889 COG3889, Predicted solute binding protein General function prediction only 152967804 Common - binding-protein-dependent transport systems inner membrane component Krad_3861 222 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 152968228 Nonpathogen - hypothetical protein Krad_4285 4 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 152966289 Common - transcription factor WhiB Krad_2328 19 None None None 152964009 Nonpathogen - hypothetical protein Krad_0037 3 None None None 152966360 Nonpathogen - hypothetical protein Krad_2400 1 None None None 152966674 Common - amino acid permease-associated region Krad_2722 31 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 152966883 Nonpathogen - hypothetical protein Krad_2939 2 None None None 152968225 Common - HpcH/HpaI aldolase Krad_4282 100 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 152967089 Common - hypothetical protein Krad_3145 12 None None None 152966852 Common - short-chain dehydrogenase/reductase SDR Krad_2908 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152965830 Common - tryptophan 23-dioxygenase Krad_1864 41 COG3483 TDO2, Tryptophan 2,3-dioxygenase (vermilion) Amino acid transport and metabolism 152966427 Common - monooxygenase FAD-binding Krad_2471 70 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 152964470 Common - regulatory protein ArsR Krad_0501 121 COG0640 ArsR, Predicted transcriptional regulators Transcription 152967129 Common - major facilitator superfamily MFS_1 Krad_3185 88 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 152965605 Nonpathogen - hypothetical protein Krad_1639 3 None None None 152968342 Common - Mandelate racemase/muconate lactonizing protein Krad_4403 109 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 152964017 Common - NADH dehydrogenase (quinone) Krad_0046 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 152966870 Common - 6-phosphogluconolactonase Krad_2926 82 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 152964131 Common - Orn/Lys/Arg decarboxylase major region Krad_0160 93 COG1982 LdcC, Arginine/lysine/ornithine decarboxylases Amino acid transport and metabolism 152966123 Common - N-acetylglucosamine-6-phosphate deacetylase Krad_2159 118 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 152965899 Common - transcriptional regulator, MarR family Krad_1933 11 COG1846 MarR, Transcriptional regulators Transcription 152966580 Nonpathogen - hypothetical protein Krad_2628 1 None None None 152965350 Common - Xanthine/uracil/vitamin C permease Krad_1382 135 COG2252 COG2252, Permeases General function prediction only 152965318 Common - two component transcriptional regulator, LuxR family Krad_1350 202 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152965955 Common - transcriptional regulator, TetR family Krad_1989 58 COG1309 AcrR, Transcriptional regulator Transcription 152964991 Common - ROK family protein Krad_1023 3 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 152967323 Common - aldo/keto reductase Krad_3379 187 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152968091 Common - protein of unknown function DUF1680 Krad_4148 31 COG3533 COG3533, Uncharacterized protein conserved in bacteria Function unknown 152963999 Common - sortase family protein Krad_0027 29 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 152965712 Nonpathogen - hypothetical protein Krad_1746 1 None None None 152965374 Common - hypothetical protein Krad_1406 17 None None None 152964587 Common - porphobilinogen deaminase Krad_0618 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 152966998 Common - Holliday junction DNA helicase RuvA Krad_3054 201 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 152964750 Common - hypothetical protein Krad_0782 14 None None None 152966187 Common - Mandelate racemase/muconate lactonizing protein Krad_2226 127 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 152965858 Common - hypothetical protein Krad_1892 18 None None None 152966418 Nonpathogen - hypothetical protein Krad_2462 1 None None None 152966653 Common - LGFP repeat protein Krad_2701 11 COG5479 COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis Cell envelope biogenesis, outer membrane 152967616 Nonpathogen - hypothetical protein Krad_3673 1 None None None 152967559 Common - Peptidyl-dipeptidase Dcp Krad_3616 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 152964850 Common - Domain of unknown function DUF1794 Krad_0882 16 None None None 152964510 Common - dihydroneopterin aldolase Krad_0541 99 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 152968247 Common - 2-dehydropantoate 2-reductase Krad_4304 24 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 152964354 Common - regulatory protein LacI Krad_0384 105 COG1609 PurR, Transcriptional regulators Transcription 152966132 Common - putative monooxygenase Krad_2169 75 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152965357 Common - drug resistance transporter, Bcr/CflA subfamily Krad_1389 211 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152964230 Nonpathogen - phosphoesterase PA-phosphatase related Krad_0260 1 None None None 152964786 Common - Alcohol dehydrogenase GroES domain protein Krad_0818 206 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 152965405 Common - putative integral membrane protein Krad_1437 12 None None None 152964260 Common - heavy metal translocating P-type ATPase Krad_0290 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 152965203 Common - protein of unknown function DUF21 Krad_1235 214 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 152967425 Common - Alanine racemase Krad_3482 126 COG1609 PurR, Transcriptional regulators Transcription 152965844 Common - hypothetical protein Krad_1878 12 None None None 152966145 Common - transcriptional regulator, TetR family Krad_2182 34 COG1309 AcrR, Transcriptional regulator Transcription 152967931 Common - isocitrate dehydrogenase, NADP-dependent Krad_3988 68 COG0538 Icd, Isocitrate dehydrogenases Energy production and conversion 152964717 Common - ABC transporter transmembrane region Krad_0748 160 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 152965579 Common - methyl-accepting chemotaxis sensory transducer Krad_1613 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152964845 Common - Polyphosphate kinase Krad_0877 161 COG0855 Ppk, Polyphosphate kinase Inorganic ion transport and metabolism 152966748 Common - glycosyl transferase group 1 Krad_2798 55 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152965110 Common - 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase Krad_1142 35 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 152966570 Nonpathogen - hypothetical protein Krad_2617 1 None None None 152964792 Nonpathogen - hypothetical protein Krad_0824 1 COG3861 COG3861, Uncharacterized protein conserved in bacteria Function unknown 152966333 Common - Antibiotic biosynthesis monooxygenase Krad_2373 5 COG1359 COG1359, Uncharacterized conserved protein Function unknown 152964449 Nonpathogen - type II secretion system protein Krad_0479 1 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion 152967562 Common - hypothetical protein Krad_3619 17 None None None 152966045 Common - transcriptional regulator, RpiR family Krad_2080 19 COG1737 RpiR, Transcriptional regulators Transcription 152968013 Common - phosphoribosylformylglycinamidine synthase, purS Krad_4070 70 COG1828 PurS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component Nucleotide transport and metabolism 152968032 Common - Amidase Krad_4089 194 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 152965811 Common - methyl-accepting chemotaxis sensory transducer Krad_1845 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152964308 Nonpathogen - hypothetical protein Krad_0338 1 None None None 152964440 Nonpathogen - hypothetical protein Krad_0470 1 None None None 152965335 Common - ribosomal protein L28 Krad_1367 61 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 152965518 Common - Ferrochelatase Krad_1552 56 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 152964535 Common - glycosyltransferase-like protein Krad_0566 85 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 152964079 Common - methylisocitrate lyase Krad_0108 132 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 152967531 Common - major facilitator superfamily MFS_1 Krad_3588 151 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152965904 Common - luciferase family protein Krad_1938 115 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152965586 Common - protein of unknown function DUF180 Krad_1620 31 COG1699 COG1699, Uncharacterized protein conserved in bacteria Function unknown 152967753 Common - two component transcriptional regulator, LuxR family Krad_3810 223 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152965989 Common - putative transcriptional regulator, XRE family Krad_2024 41 COG1396 HipB, Predicted transcriptional regulators Transcription 152965467 Common - RNA modification enzyme, MiaB family Krad_1499 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 152967235 Common - glutamine synthetase, type I Krad_3291 224 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 152967653 Nonpathogen - hypothetical protein Krad_3710 8 COG4412 COG4412, Uncharacterized protein conserved in bacteria Function unknown 152965299 Common - molybdopterin oxidoreductase Krad_1331 196 COG0369 CysJ, Sulfite reductase, alpha subunit (flavoprotein) Inorganic ion transport and metabolism 152968204 Common - methyl-accepting chemotaxis sensory transducer Krad_4261 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152966593 Common - Phosphoglycerate mutase Krad_2641 15 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 152966706 Nonpathogen - aminoglycoside phosphotransferase Krad_2754 4 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 152966251 Nonpathogen - hypothetical protein Krad_2290 1 None None None 152968076 Common - NUDIX hydrolase Krad_4133 128 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 152964959 Common - luciferase family protein Krad_0991 97 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152966339 Nonpathogen - hypothetical protein Krad_2379 1 None None None 152964930 Common - Alpha-N-arabinofuranosidase Krad_0962 30 COG3534 AbfA, Alpha-L-arabinofuranosidase Carbohydrate transport and metabolism 152965483 Common - luciferase family protein Krad_1515 105 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152967702 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_3759 75 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152967997 Common - periplasmic binding protein/LacI transcriptional regulator Krad_4054 77 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152967043 Common - protein of unknown function DUF1290 Krad_3099 25 COG3856 Sbp, Uncharacterized conserved protein (small basic protein) Function unknown 152967730 Common - type II secretion system protein Krad_3787 8 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion 152964436 Common - DNA polymerase III, subunits gamma and tau Krad_0466 246 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 152964489 Nonpathogen - hypothetical protein Krad_0520 2 None None None 152966280 Common - ABC transporter-related protein Krad_2319 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 152968255 Common - alpha/beta hydrolase fold Krad_4312 42 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152966160 Nonpathogen - hypothetical protein Krad_2197 4 None None None 152964847 Common - putative two component transcriptional regulator, winged helix family Krad_0879 199 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152966466 Nonpathogen - hypothetical protein Krad_2511 1 None None None 152967499 Common - NUDIX hydrolase Krad_3556 98 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 152967347 Common - PAS sensor protein Krad_3403 87 None None None 152966293 Common - plasmid encoded RepA protein Krad_2333 19 None None None 152968240 Common - Alcohol dehydrogenase zinc-binding domain protein Krad_4297 134 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 152967685 Common - putative PAS/PAC sensor protein Krad_3742 9 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 152967447 Common - methyl-accepting chemotaxis sensory transducer Krad_3504 151 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152965040 Nonpathogen - hypothetical protein Krad_1072 1 None None None 152968176 Common - chaperone protein DnaK Krad_4233 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 152967774 Common - transcriptional regulator, TetR family Krad_3831 10 COG1309 AcrR, Transcriptional regulator Transcription 152967781 Common - adenosylhomocysteinase Krad_3838 177 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 152967336 Common - peptidase M42 family protein Krad_3392 30 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 152964808 Common - amino acid permease-associated region Krad_0840 70 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 152965733 Nonpathogen - hypothetical protein Krad_1767 1 None None None 152964413 Common - ABC transporter-related protein Krad_0443 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 152964575 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Krad_0606 167 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152965882 Common - 3-hydroxyacyl-CoA dehydrogenase NAD-binding Krad_1916 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 152965192 Common - extracellular solute-binding protein family 3 Krad_1224 154 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 152967384 Common - secreted protein Krad_3441 30 None None None 152965624 Common - protein of unknown function DUF1078 domain protein Krad_1658 129 COG1749 FlgE, Flagellar hook protein FlgE Cell motility and secretion 152965885 Common - Glycerone kinase Krad_1919 77 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 152966558 Common - major facilitator superfamily MFS_1 Krad_2605 19 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 152964082 Common - CutC family protein Krad_0111 52 COG3142 CutC, Uncharacterized protein involved in copper resistance Inorganic ion transport and metabolism 152967354 Nonpathogen - hypothetical protein Krad_3410 1 None None None 152967878 Common - adenosine deaminase Krad_3935 103 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 152968318 Nonpathogen - hypothetical protein Krad_4375 1 None None None 152967506 Common - hypothetical protein Krad_3563 8 None None None 152964633 Common - hypothetical protein Krad_0664 24 COG2030 MaoC, Acyl dehydratase Lipid metabolism 152966723 Nonpathogen - hypothetical protein Krad_2773 1 None None None 152965678 Nonpathogen - hypothetical protein Krad_1712 1 None None None 152967952 Common - putative transglycosylase associated protein Krad_4009 6 COG2261 COG2261, Predicted membrane protein Function unknown 152968135 Common - 5-carboxymethyl-2-hydroxymuconate Delta-isomerase Krad_4192 179 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 152967844 Common - cell envelope-related transcriptional attenuator Krad_3901 63 COG1316 LytR, Transcriptional regulator Transcription 152968182 Common - CsbD family protein Krad_4239 3 None None None 152966895 Common - DNA polymerase I Krad_2951 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 152966845 Common - glucose-1-phosphate adenylyltransferase Krad_2901 178 COG0448 GlgC, ADP-glucose pyrophosphorylase Carbohydrate transport and metabolism 152967210 Common - hypothetical protein Krad_3266 7 None None None 152965282 Common - hypothetical protein Krad_1314 36 COG4222 COG4222, Uncharacterized protein conserved in bacteria Function unknown 152967959 Common - binding-protein-dependent transport systems inner membrane component Krad_4016 189 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152967362 Common - GTP-binding protein LepA Krad_3418 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 152965708 Nonpathogen - hypothetical protein Krad_1742 1 None None None 152965853 Common - 5'-3' exonuclease Krad_1887 215 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 152966404 Nonpathogen - hypothetical protein Krad_2445 1 None None None 152965023 Common - glycosyl transferase group 1 Krad_1055 168 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152964538 Common - glucose-1-phosphate cytidylyltransferase Krad_0569 148 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 152965675 Nonpathogen - hypothetical protein Krad_1709 1 None None None 152967147 Common - UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase Krad_3203 200 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 152964581 Common - phage transcriptional regulator, AlpA Krad_0612 26 COG3311 AlpA, Predicted transcriptional regulator Transcription 152967494 Common - HNH endonuclease Krad_3551 95 COG1403 McrA, Restriction endonuclease Defense mechanisms 152967624 Common - Undecaprenyl-phosphate galactose phosphotransferase Krad_3681 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 152965760 Common - hypothetical protein Krad_1794 6 None None None 152964517 Common - membrane-flanked domain Krad_0548 24 COG3428 COG3428, Predicted membrane protein Function unknown 152966959 Common - putative cell wall binding repeat 2-containing protein Krad_3015 5 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 152967015 Nonpathogen - amidohydrolase 2 Krad_3071 6 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 152966846 Common - hypothetical protein Krad_2902 29 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152965277 Common - protein of unknown function DUF445 Krad_1309 49 COG2733 COG2733, Predicted membrane protein Function unknown 152966273 Common - putative transcriptional regulator, MerR family Krad_2312 88 COG0789 SoxR, Predicted transcriptional regulators Transcription 152966358 Nonpathogen - hypothetical protein Krad_2398 1 None None None 152965933 Common - luciferase family protein Krad_1967 87 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152965667 Nonpathogen - hypothetical protein Krad_1701 1 None None None 152965644 Common - diguanylate cyclase with PAS/PAC sensor Krad_1678 168 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152967677 Common - ROK family protein Krad_3734 72 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 152967886 Common - diguanylate cyclase/phosphodiesterase Krad_3943 169 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152967481 Common - alpha amylase catalytic region Krad_3538 158 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 152967263 Common - ROK family protein Krad_3319 35 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 152966110 Common - 6-phosphogluconate dehydrogenase NAD-binding Krad_2146 193 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 152967461 Common - trigger factor Krad_3518 215 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 152968377 Common - Dihydrofolate reductase Krad_4438 144 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 152967334 Common - diguanylate cyclase with PAS/PAC sensor Krad_3390 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152964438 Nonpathogen - hypothetical protein Krad_0468 1 None None None 152965132 Common - multiple antibiotic resistance (MarC)-related protein Krad_1164 128 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 152965602 Common - peptidase C26 Krad_1636 131 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 152968134 Common - twin-arginine translocation pathway signal Krad_4191 17 None None None 152966616 Common - diacylglycerol kinase catalytic region Krad_2664 118 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 152965502 Common - DNA topoisomerase (ATP-hydrolyzing) Krad_1534 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 152965898 Common - luciferase family protein Krad_1932 81 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152968151 Common - Cupin 2 conserved barrel domain protein Krad_4208 8 None None None 152964839 Common - phosphate transporter Krad_0871 165 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 152966240 Nonpathogen - hypothetical protein Krad_2279 1 None None None 152964772 Common - NrdI protein Krad_0804 38 COG1780 NrdI, Protein involved in ribonucleotide reduction Nucleotide transport and metabolism 152966476 Nonpathogen - hypothetical protein Krad_2521 1 None None None 152968310 Nonpathogen - hypothetical protein Krad_4367 2 None None None 152967201 Common - putative integral membrane protein Krad_3257 18 None None None 152966031 Common - Cytosine deaminase Krad_2066 154 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 152965688 Common - hypothetical protein Krad_1722 4 None None None 152967318 Common - Phosphoglycerate mutase Krad_3374 161 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 152966231 Common - GCN5-related N-acetyltransferase Krad_2270 5 COG1444 COG1444, Predicted P-loop ATPase fused to an acetyltransferase General function prediction only 152965784 Common - putative undecaprenol kinase Krad_1818 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 152964043 Common - protein kinase Krad_0072 157 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 152967515 Common - periplasmic binding protein/LacI transcriptional regulator Krad_3572 120 COG1609 PurR, Transcriptional regulators Transcription 152968396 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Krad_4457 25 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 152967119 Common - Imidazoleglycerol-phosphate dehydratase Krad_3175 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 152966445 Common - citrate/H+ symporter, CitMHS family Krad_2489 34 COG2851 CitM, H+/citrate symporter Energy production and conversion 152967489 Common - putative cell wall binding repeat 2-containing protein Krad_3546 8 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 152966808 Common - AAA ATPase central domain protein Krad_2862 79 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 152966961 Nonpathogen - hypothetical protein Krad_3017 3 COG3167 PilO, Tfp pilus assembly protein PilO Cell motility and secretion / Intracellular trafficking and secretion 152967222 Common - dihydrolipoamide dehydrogenase Krad_3278 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 152966023 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Krad_2058 163 COG0388 COG0388, Predicted amidohydrolase General function prediction only 152966260 Common - histidine kinase Krad_2299 184 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152968266 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Krad_4323 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152965115 Common - integral membrane protein Krad_1147 6 COG5542 COG5542, Predicted integral membrane protein Function unknown 152966758 Common - Methyltransferase type 12 Krad_2808 8 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 152967000 Common - crossover junction endodeoxyribonuclease RuvC Krad_3056 181 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 152967449 Common - AMP-dependent synthetase and ligase Krad_3506 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152966375 Nonpathogen - hypothetical protein Krad_2415 1 None None None 152964297 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Krad_0327 65 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 152966734 Common - ABC transporter-related protein Krad_2784 249 COG3638 COG3638, ABC-type phosphate/phosphonate transport system, ATPase component Inorganic ion transport and metabolism 152966314 Nonpathogen - hypothetical protein Krad_2354 1 None None None 152968273 Common - luciferase family protein Krad_4330 115 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152966533 Common - oxidoreductase domain protein Krad_2578 153 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152964830 Common - NmrA family protein Krad_0862 91 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152966299 Nonpathogen - hypothetical protein Krad_2339 1 None None None 152967927 Nonpathogen - hypothetical protein Krad_3984 2 None None None 152966628 Nonpathogen - CopG domain protein DNA-binding domain protein Krad_2676 2 None None None 152966249 Common - NmrA family protein Krad_2288 35 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152966287 Nonpathogen - hypothetical protein Krad_2326 1 None None None 152967920 Common - ABC transporter-related protein Krad_3977 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 152966349 Nonpathogen - hypothetical protein Krad_2389 1 None None None 152967538 Common - periplasmic binding protein/LacI transcriptional regulator Krad_3595 125 COG1609 PurR, Transcriptional regulators Transcription 152965307 Common - Cupin 4 family protein Krad_1339 34 COG2850 COG2850, Uncharacterized conserved protein Function unknown 152967227 Common - peptidase S51 dipeptidase E Krad_3283 13 COG3340 PepE, Peptidase E Amino acid transport and metabolism 152965940 Common - regulatory protein ArsR Krad_1974 49 COG0640 ArsR, Predicted transcriptional regulators Transcription 152966434 Common - drug resistance transporter, EmrB/QacA subfamily Krad_2478 174 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152968381 Nonpathogen - hypothetical protein Krad_4442 6 COG4671 COG4671, Predicted glycosyl transferase General function prediction only 152966490 Common - drug resistance transporter, EmrB/QacA subfamily Krad_2535 226 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152965457 Common - DEAD/H associated domain protein Krad_1489 169 COG1201 Lhr, Lhr-like helicases General function prediction only 152967154 Common - protein of unknown function DUF58 Krad_3210 21 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 152966351 Common - ThiJ/PfpI domain protein Krad_2391 87 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 152967464 Common - DNA-(apurinic or apyrimidinic site) lyase Krad_3521 178 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 152964718 Common - GMP synthase, large subunit Krad_0749 240 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 152964589 Common - Porphobilinogen synthase Krad_0620 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 152966571 Common - hypothetical protein Krad_2618 6 None None None 152964130 Nonpathogen - hypothetical protein Krad_0159 1 None None None 152966884 Common - excinuclease ABC, A subunit Krad_2940 231 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 152968112 Common - phospholipid/glycerol acyltransferase Krad_4169 118 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 152965272 Common - binding-protein-dependent transport systems inner membrane component Krad_1304 101 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 152965225 Common - peptide chain release factor 1 Krad_1257 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 152967311 Common - periplasmic binding protein/LacI transcriptional regulator Krad_3367 128 COG1609 PurR, Transcriptional regulators Transcription 152966600 Common - beta-lactamase domain protein Krad_2648 4 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 152964190 Nonpathogen - glycoside hydrolase 15-related Krad_0219 2 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 152968162 Common - Abortive infection protein Krad_4219 28 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 152964625 Common - Ferredoxin--NADP(+) reductase Krad_0656 181 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 152966389 Nonpathogen - hypothetical protein Krad_2429 1 None None None 152964822 Common - phosphomethylpyrimidine kinase Krad_0854 217 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 152968194 Common - transcriptional regulator, MarR family Krad_4251 45 COG1846 MarR, Transcriptional regulators Transcription 152964854 Common - putative integral membrane protein Krad_0886 9 None None None 152964385 Common - acetate--CoA ligase Krad_0415 216 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 152965425 Common - periplasmic binding protein/LacI transcriptional regulator Krad_1457 108 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152967706 Common - ribonuclease PH Krad_3763 183 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 152967063 Common - chorismate mutase Krad_3119 39 COG4401 AroH, Chorismate mutase Amino acid transport and metabolism 152966743 Nonpathogen - hypothetical protein Krad_2793 1 None None None 152967283 Common - formate dehydrogenase family accessory protein FdhD Krad_3339 136 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 152967635 Common - sodium/hydrogen exchanger Krad_3692 138 COG3263 COG3263, NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain Inorganic ion transport and metabolism 152965631 Nonpathogen - hypothetical protein Krad_1665 1 COG3190 FliO, Flagellar biogenesis protein Cell motility and secretion 152967391 Common - Phosphoglycerate mutase Krad_3448 123 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 152965397 Common - 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase Krad_1429 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 152964305 Nonpathogen - hypothetical protein Krad_0335 1 None None None 152967208 Common - cytochrome oxidase assembly Krad_3264 18 COG1612 CtaA, Uncharacterized protein required for cytochrome oxidase assembly Posttranslational modification, protein turnover, chaperones 152966607 Common - NmrA family protein Krad_2655 89 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152967819 Common - protein of unknown function DUF1501 Krad_3876 46 COG4102 COG4102, Uncharacterized protein conserved in bacteria Function unknown 152964526 Common - Methyltransferase type 11 Krad_0557 47 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152965809 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Krad_1843 148 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 152967432 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Krad_3489 42 COG3607 COG3607, Predicted lactoylglutathione lyase General function prediction only 152963975 Common - 6-phosphogluconate dehydrogenase, decarboxylating Krad_0003 160 COG1023 Gnd, Predicted 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 152965526 Common - hypothetical protein Krad_1560 17 None None None 152967794 Common - LPPG domain containing protein Krad_3851 39 COG0391 COG0391, Uncharacterized conserved protein Function unknown 152966561 Common - transcriptional regulator, HxlR family Krad_2608 133 COG1733 COG1733, Predicted transcriptional regulators Transcription 152964566 Common - carbohydrate kinase, thermoresistant glucokinase family Krad_0597 80 COG3265 GntK, Gluconate kinase Carbohydrate transport and metabolism 152967987 Common - transcriptional regulator, LysR family Krad_4044 187 COG0583 LysR, Transcriptional regulator Transcription 152967054 Common - luciferase family protein Krad_3110 83 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152964275 Common - aldo/keto reductase Krad_0305 203 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152967455 Common - transcriptional regulator, MarR family Krad_3512 22 COG1846 MarR, Transcriptional regulators Transcription 152966217 Common - GCN5-related N-acetyltransferase Krad_2256 13 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 152966576 Nonpathogen - protein of unknown function DUF1648 Krad_2624 1 None None None 152968216 Common - metallophosphoesterase Krad_4273 14 COG1409 Icc, Predicted phosphohydrolases General function prediction only 152966976 Common - alanyl-tRNA synthetase Krad_3032 248 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152966549 Common - hypothetical protein Krad_2595 3 None None None 152966134 Common - binding-protein-dependent transport systems inner membrane component Krad_2171 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 152967294 Common - Dyp-type peroxidase family Krad_3350 44 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 152968186 Common - deoxycytidine triphosphate deaminase Krad_4243 166 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 152966522 Nonpathogen - hypothetical protein Krad_2567 1 None None None 152964743 Common - Alanine racemase Krad_0775 126 COG1609 PurR, Transcriptional regulators Transcription 152966499 Common - binding-protein-dependent transport systems inner membrane component Krad_2544 141 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152964217 Common - diguanylate cyclase Krad_0247 166 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152966966 Nonpathogen - hypothetical protein Krad_3022 1 COG4795 PulJ, Type II secretory pathway, component PulJ Intracellular trafficking and secretion 152964450 Nonpathogen - TadE family protein Krad_0480 1 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 152967630 Common - molybdenum cofactor biosynthesis protein C Krad_3687 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 152964221 Common - hypothetical protein Krad_0251 5 None None None 152964996 Common - Phosphoglycerate mutase Krad_1028 121 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 152968289 Common - peptidase S58 DmpA Krad_4346 47 COG3191 DmpA, L-aminopeptidase/D-esterase Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152967768 Common - ABC transporter transmembrane region Krad_3825 14 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 152965143 Common - aminoglycoside phosphotransferase Krad_1175 15 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 152964726 Common - ATP-dependent DNA helicase PcrA Krad_0757 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 152968408 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_4469 143 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152965794 Common - NAD-dependent epimerase/dehydratase Krad_1828 219 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152965994 Common - GCN5-related N-acetyltransferase Krad_2029 123 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 152966405 Nonpathogen - hypothetical protein Krad_2446 1 None None None 152968008 Common - hypothetical protein Krad_4065 18 COG1846 MarR, Transcriptional regulators Transcription 152964829 Common - hypothetical protein Krad_0861 27 COG3662 COG3662, Uncharacterized protein conserved in bacteria Function unknown 152968282 Common - ribosomal protein S6 Krad_4339 189 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 152966486 Common - glycoside hydrolase family 3 domain protein Krad_2531 156 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 152966592 Nonpathogen - hypothetical protein Krad_2640 1 None None None 152965658 Common - hypothetical protein Krad_1692 7 COG5373 COG5373, Predicted membrane protein Function unknown 152966209 Nonpathogen - hypothetical protein Krad_2248 1 None None None 152966803 Common - NmrA family protein Krad_2857 7 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152964518 Common - Alanine racemase Krad_0549 126 COG1609 PurR, Transcriptional regulators Transcription 152964021 Common - metal dependent phosphohydrolase Krad_0050 6 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 152967955 Common - transcriptional regulator, LysR family Krad_4012 61 COG0583 LysR, Transcriptional regulator Transcription 152966103 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Krad_2139 220 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 152968304 Common - ABC transporter-related protein Krad_4361 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 152967566 Common - hypothetical protein Krad_3623 7 None None None 152964816 Common - thioredoxin Krad_0848 232 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 152967880 Common - protein of unknown function DUF6 transmembrane Krad_3937 14 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 152966163 Common - diguanylate cyclase/phosphodiesterase with GAF sensor Krad_2200 177 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152967130 Nonpathogen - hypothetical protein Krad_3186 1 None None None 152967697 Common - cytochrome P450 Krad_3754 71 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 152963993 Nonpathogen - mucin-associated surface protein (MASP) Krad_0021 1 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 152967741 Common - hypothetical protein Krad_3798 7 None None None 152967196 Common - Rieske (2Fe-2S) domain protein Krad_3252 37 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 152966539 Nonpathogen - putative diguanylate phosphodiesterase Krad_2585 1 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152965076 Common - secreted protein Krad_1108 13 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 152966257 Nonpathogen - hypothetical protein Krad_2296 1 None None None 152966904 Common - glutamate synthase, NADH/NADPH, small subunit Krad_2960 207 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 152965126 Common - MgtE intracellular region Krad_1158 166 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 152964109 Common - Alkaline phosphatase Krad_0138 59 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 152966774 Common - DGPFAETKE family protein Krad_2826 24 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 152964425 Common - alpha/beta hydrolase fold Krad_0455 111 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152966195 Nonpathogen - LrgA family protein Krad_2234 1 COG1380 COG1380, Putative effector of murein hydrolase LrgA General function prediction only 152965611 Nonpathogen - hypothetical protein Krad_1645 1 None None None 152964054 Common - hypothetical protein Krad_0083 6 None None None 152965389 Common - hypothetical protein Krad_1421 8 None None None 152964912 Common - protein of unknown function zinc metallopeptidase putative Krad_0944 87 COG2321 COG2321, Predicted metalloprotease General function prediction only 152965403 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Krad_1435 181 COG0388 COG0388, Predicted amidohydrolase General function prediction only 152965977 Common - Stage II sporulation E family protein Krad_2012 32 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152965015 Common - ABC transporter-related protein Krad_1047 247 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 152967833 Common - glycosyl transferase family 2 Krad_3890 65 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 152966641 Common - putative epoxide hydratase Krad_2689 35 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152966179 Common - Alcohol dehydrogenase zinc-binding domain protein Krad_2218 158 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 152964767 Common - major facilitator superfamily MFS_1 Krad_0799 12 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152966938 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Krad_2994 248 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 152967439 Common - hypothetical protein Krad_3496 8 None None None 152965674 Nonpathogen - hypothetical protein Krad_1708 1 None None None 152965877 Common - hydrolase of the alpha/beta superfamily protein Krad_1911 63 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 152968338 Common - GntR domain protein Krad_4399 83 COG2186 FadR, Transcriptional regulators Transcription 152967941 Common - succinyl-CoA synthetase, alpha subunit Krad_3998 218 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 152965911 Common - short-chain dehydrogenase/reductase SDR Krad_1945 236 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 152967274 Common - integral membrane sensor signal transduction histidine kinase Krad_3330 56 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152968021 Common - aminotransferase class-III Krad_4078 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 152965545 Common - Rhodanese domain protein Krad_1579 16 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152965592 Common - flagellin domain protein Krad_1626 114 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 152965411 Common - translation initiation factor IF-2 Krad_1443 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 152965368 Common - 16S rRNA processing protein RimM Krad_1400 147 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 152964312 Common - protein of unknown function DUF664 Krad_0342 9 None None None 152965240 Common - hypothetical protein Krad_1272 11 None None None 152965391 Common - transcriptional regulator, PucR family Krad_1423 21 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 152965128 Common - hypothetical protein Krad_1160 18 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 152967182 Common - putative glucokinase, ROK family Krad_3238 158 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 152968439 Common - coagulation factor 5/8 type domain protein Krad_4500 21 None None None 152965609 Common - transcriptional repressor, CopY family Krad_1643 38 COG3682 COG3682, Predicted transcriptional regulator Transcription 152967251 Common - putative citrate lyase beta subunit Krad_3307 22 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 152966057 Common - binding-protein-dependent transport systems inner membrane component Krad_2092 147 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152968368 Common - Endothelin-converting enzyme 1 Krad_4429 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 152964932 Common - binding-protein-dependent transport systems inner membrane component Krad_0964 148 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152966927 Common - Fmu (Sun) domain protein Krad_2983 178 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 152968103 Common - FAD linked oxidase domain protein Krad_4160 71 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 152965104 Common - Acyl-CoA dehydrogenase type 2 domain Krad_1136 32 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 152968391 Common - urocanate hydratase Krad_4452 97 COG2987 HutU, Urocanate hydratase Amino acid transport and metabolism 152967625 Common - glycosyl transferase group 1 Krad_3682 129 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152966940 Common - binding-protein-dependent transport systems inner membrane component Krad_2996 216 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 152967190 Common - Methyltransferase type 11 Krad_3246 108 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152967973 Common - acyl-CoA dehydrogenase domain protein Krad_4030 117 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 152967473 Common - Prolyl oligopeptidase Krad_3530 110 COG1505 COG1505, Serine proteases of the peptidase family S9A Amino acid transport and metabolism 152964706 Common - transcription factor WhiB Krad_0737 19 None None None 152965751 Common - hypothetical protein Krad_1785 16 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152968116 Common - putative ABC transporter Krad_4173 37 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 152968128 Nonpathogen - hypothetical protein Krad_4185 1 None None None 152968042 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase Krad_4099 193 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 152967094 Common - HAD-superfamily hydrolase, subfamily IIA Krad_3150 38 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 152964156 Common - transcriptional regulator, GntR family Krad_0185 57 COG1802 GntR, Transcriptional regulators Transcription 152965724 Common - hypothetical protein Krad_1758 2 None None None 152965326 Common - 3-isopropylmalate dehydratase, large subunit Krad_1358 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 152968305 Nonpathogen - hypothetical protein Krad_4362 1 None None None 152964261 Common - major facilitator superfamily MFS_1 Krad_0291 31 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 152964197 Common - ribosomal protein L33 Krad_0226 127 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 152964942 Common - binding-protein-dependent transport systems inner membrane component Krad_0974 152 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152964123 Common - NADH:flavin oxidoreductase/NADH oxidase Krad_0152 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 152968038 Nonpathogen - hypothetical protein Krad_4095 4 None None None 152967245 Common - Pyridoxal-5'-phosphate-dependent protein beta subunit Krad_3301 209 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 152965408 Common - protein of unknown function DUF150 Krad_1440 17 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 152968262 Common - 23S rRNA (uracil-5-)-methyltransferase RumB Krad_4319 188 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 152967542 Common - putative transcriptional regulator, GntR family Krad_3599 167 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 152965947 Common - two component transcriptional regulator, LuxR family Krad_1981 213 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152964210 Common - amino acid permease-associated region Krad_0240 99 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 152968295 Nonpathogen - hypothetical protein Krad_4352 1 None None None 152965265 Common - alpha amylase catalytic region Krad_1297 91 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 152964408 Common - binding-protein-dependent transport systems inner membrane component Krad_0438 181 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 152967322 Common - transcriptional regulator, LysR family Krad_3378 178 COG0583 LysR, Transcriptional regulator Transcription 152966934 Common - phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase Krad_2990 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 152967126 Common - peptidase S16 lon domain protein Krad_3182 100 COG2802 COG2802, Uncharacterized protein, similar to the N-terminal domain of Lon protease General function prediction only 152967900 Nonpathogen - hypothetical protein Krad_3957 3 None None None 152968451 Common - ribonuclease P protein component Krad_4512 29 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 152966493 Common - integral membrane sensor signal transduction histidine kinase Krad_2538 108 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152968324 Common - hypothetical protein Krad_4381 83 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 152965315 Common - Antibiotic biosynthesis monooxygenase Krad_1347 16 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 152964067 Common - glycoside hydrolase 15-related Krad_0096 71 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 152964865 Nonpathogen - putative lipoprotein Krad_0897 1 None None None 152964401 Common - GatB/Yqey domain protein Krad_0431 145 COG1610 COG1610, Uncharacterized conserved protein Function unknown 152966638 Nonpathogen - transcriptional regulator, TetR family Krad_2686 3 COG1309 AcrR, Transcriptional regulator Transcription 152964039 Common - protein of unknown function DUF112 transmembrane Krad_0068 75 COG3333 COG3333, Uncharacterized protein conserved in bacteria Function unknown 152967376 Common - CHAD domain containing protein Krad_3433 51 COG5607 COG5607, Uncharacterized conserved protein Function unknown 152964733 Common - Argininosuccinate synthase Krad_0765 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 152964751 Common - Heavy metal transport/detoxification protein Krad_0783 44 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 152965160 Nonpathogen - hypothetical protein Krad_1192 1 None None None 152965861 Common - peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin Krad_1895 16 COG1876 VanY, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 152966202 Nonpathogen - hypothetical protein Krad_2241 2 None None None 152964093 Common - Stage II sporulation E family protein Krad_0122 76 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152965167 Common - glutamine amidotransferase class-I Krad_1199 171 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 152968432 Common - hypothetical protein Krad_4493 8 None None None 152965036 Common - Endo-1,4-beta-xylanase Krad_1068 35 COG3693 XynA, Beta-1,4-xylanase Carbohydrate transport and metabolism 152965416 Common - transcriptional regulator, TetR family Krad_1448 31 COG1309 AcrR, Transcriptional regulator Transcription 152966722 Nonpathogen - hypothetical protein Krad_2772 1 None None None 152965219 Common - diaminopimelate decarboxylase Krad_1251 218 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 152966664 Common - short-chain dehydrogenase/reductase SDR Krad_2712 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152964892 Common - conserved hypothetical membrane associated protein Krad_0924 8 None None None 152966149 Nonpathogen - hypothetical protein Krad_2186 1 None None None 152966693 Common - glycoside hydrolase family 3 domain protein Krad_2741 110 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 152968086 Common - protein of unknown function DUF161 Krad_4143 25 COG2364 COG2364, Predicted membrane protein Function unknown 152965969 Common - acyltransferase 3 Krad_2004 7 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 152966414 Common - transposase IS3/IS911 family protein Krad_2458 21 None None None 152967684 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Krad_3741 7 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152967961 Nonpathogen - hypothetical protein Krad_4018 1 None None None 152965731 Nonpathogen - hypothetical protein Krad_1765 1 None None None 152964146 Common - aldo/keto reductase Krad_0175 171 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152965157 Common - ROK family protein Krad_1189 109 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 152965676 Common - Transglycosylase domain protein Krad_1710 21 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 152967071 Nonpathogen - hypothetical protein Krad_3127 1 None None None 152964757 Common - cyclase/dehydrase Krad_0789 11 COG4276 COG4276, Uncharacterized conserved protein Function unknown 152966564 Common - hypothetical protein Krad_2611 2 None None None 152965150 Nonpathogen - hypothetical protein Krad_1182 1 None None None 152965209 Common - transport system permease protein Krad_1241 187 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 152964099 Common - Chloride peroxidase Krad_0128 70 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152967216 Common - aldehyde dehydrogenase Krad_3272 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 152965888 Common - peptidase M20 Krad_1922 184 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 152965001 Common - transcriptional regulator, PadR-like family Krad_1033 65 COG1695 COG1695, Predicted transcriptional regulators Transcription 152964298 Common - glycosyl transferase family 2 Krad_0328 115 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152966690 Common - AraC-type transcriptional regulator domain protein Krad_2738 75 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 152965742 Nonpathogen - hypothetical protein Krad_1776 1 None None None 152967288 Common - 3-oxoacyl-(acyl-carrier-protein) synthase III Krad_3344 199 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 152966322 Nonpathogen - hypothetical protein Krad_2362 4 None None None 152965763 Nonpathogen - hypothetical protein Krad_1797 1 COG5653 COG5653, Protein involved in cellulose biosynthesis (CelD) Cell envelope biogenesis, outer membrane 152964958 Common - protein of unknown function DUF1212 Krad_0990 12 COG2966 COG2966, Uncharacterized conserved protein Function unknown 152967933 Nonpathogen - hypothetical protein Krad_3990 1 None None None 152964073 Common - Antibiotic biosynthesis monooxygenase Krad_0102 5 COG1359 COG1359, Uncharacterized conserved protein Function unknown 152965517 Common - DNA-binding protein Krad_1551 17 COG5373 COG5373, Predicted membrane protein Function unknown 152964708 Common - two component transcriptional regulator, LuxR family Krad_0739 180 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152965839 Common - 20S proteasome A and B subunits Krad_1873 48 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 152967907 Common - extracellular solute-binding protein family 1 Krad_3964 29 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152968051 Common - Ku family containing protein Krad_4108 63 COG1273 COG1273, Uncharacterized conserved protein Function unknown 152967857 Nonpathogen - hypothetical protein Krad_3914 1 None None None 152966011 Common - hypothetical protein Krad_2046 22 None None None 152967044 Common - protein of unknown function DUF881 Krad_3100 25 COG3879 COG3879, Uncharacterized protein conserved in bacteria Function unknown 152966061 Common - diguanylate cyclase Krad_2096 182 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152967356 Nonpathogen - protein of unknown function DUF1206 Krad_3412 1 None None None 152967773 Common - Triacylglycerol lipase Krad_3830 13 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 152966068 Common - Stage II sporulation E family protein Krad_2103 58 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152967527 Common - short-chain dehydrogenase/reductase SDR Krad_3584 199 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 152968258 Common - membrane protein Krad_4315 18 None None None 152966468 Nonpathogen - hypothetical protein Krad_2513 1 None None None 152967645 Common - periplasmic binding protein Krad_3702 46 COG4607 CeuA, ABC-type enterochelin transport system, periplasmic component Inorganic ion transport and metabolism 152966462 Common - short-chain dehydrogenase/reductase SDR Krad_2507 68 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152964315 Common - Alcohol dehydrogenase GroES domain protein Krad_0345 200 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 152968312 Nonpathogen - hypothetical protein Krad_4369 1 None None None 152966786 Nonpathogen - hypothetical protein Krad_2838 1 None None None 152965091 Common - hydroxymethylbutenyl pyrophosphate reductase Krad_1123 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 152967754 Common - sigma 54 modulation protein/ribosomal protein S30EA Krad_3811 65 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 152967577 Common - FAD linked oxidase domain protein Krad_3634 30 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 152964199 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Krad_0228 110 COG0546 Gph, Predicted phosphatases General function prediction only 152967986 Common - major facilitator superfamily MFS_1 Krad_4043 2 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152966931 Common - aldo/keto reductase Krad_2987 200 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152964088 Common - binding-protein-dependent transport systems inner membrane component Krad_0117 132 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152964457 Common - DNA topoisomerase I Krad_0487 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 152966854 Common - ABC transporter-related protein Krad_2910 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 152965887 Common - transcriptional regulator, GntR family Krad_1921 120 COG1802 GntR, Transcriptional regulators Transcription 152966990 Common - protein of unknown function DUF349 Krad_3046 37 None None None 152964268 Common - glycerophosphoryl diester phosphodiesterase Krad_0298 41 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 152968148 Common - Mannitol dehydrogenase domain Krad_4205 90 COG0246 MtlD, Mannitol-1-phosphate/altronate dehydrogenases Carbohydrate transport and metabolism 152965863 Common - Integral membrane protein TerC Krad_1897 95 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 152964375 Common - hypothetical protein Krad_0405 2 None None None 152965198 Common - two component transcriptional regulator, winged helix family Krad_1230 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152967111 Common - ribosomal protein L20 Krad_3167 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 152965533 Nonpathogen - hypothetical protein Krad_1567 2 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 152968235 Common - hypothetical protein Krad_4292 7 None None None 152968417 Common - putative PAS/PAC sensor protein Krad_4478 83 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152965762 Nonpathogen - hypothetical protein Krad_1796 1 None None None 152965832 Common - AAA ATPase central domain protein Krad_1866 249 COG1222 RPT1, ATP-dependent 26S proteasome regulatory subunit Posttranslational modification, protein turnover, chaperones 152967806 Common - extracellular solute-binding protein family 5 Krad_3863 206 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 152966429 Nonpathogen - hypothetical protein Krad_2473 1 None None None 152967553 Common - hypothetical protein Krad_3610 15 None None None 152964416 Common - protein of unknown function DUF21 Krad_0446 192 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 152968018 Common - pyridoxal kinase Krad_4075 73 COG2240 PdxK, Pyridoxal/pyridoxine/pyridoxamine kinase Coenzyme metabolism 152964650 Common - DNA-directed RNA polymerase, beta' subunit Krad_0681 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 152965626 Common - MotA/TolQ/ExbB proton channel Krad_1660 84 COG1291 MotA, Flagellar motor component Cell motility and secretion 152967655 Common - methylated-DNA--protein-cysteine methyltransferase Krad_3712 218 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 152968413 Nonpathogen - hypothetical protein Krad_4474 1 None None None 152967405 Common - monoxygenase Krad_3462 75 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152964788 Common - NAD-dependent epimerase/dehydratase Krad_0820 68 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152966582 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_2630 38 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152968132 Common - binding-protein-dependent transport systems inner membrane component Krad_4189 124 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152967364 Common - hypothetical protein Krad_3420 4 COG4371 COG4371, Predicted membrane protein Function unknown 152965376 Common - Mg chelatase, subunit ChlI Krad_1408 187 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 152965981 Common - ABC-2 type transporter Krad_2016 26 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 152966147 Nonpathogen - hypothetical protein Krad_2184 1 None None None 152964998 Common - Endoribonuclease L-PSP Krad_1030 177 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 152968126 Common - protein of unknown function UPF0029 Krad_4183 69 COG1739 COG1739, Uncharacterized conserved protein Function unknown 152965461 Common - regulatory protein RecX Krad_1493 26 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 152965983 Common - putative transcriptional regulator, MerR family Krad_2018 78 COG0789 SoxR, Predicted transcriptional regulators Transcription 152967496 Common - iron dependent repressor Krad_3553 82 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 152964630 Common - hypothetical protein Krad_0661 18 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 152966255 Common - glutathione-dependent formaldehyde-activating GFA Krad_2294 56 COG3791 COG3791, Uncharacterized conserved protein Function unknown 152966420 Nonpathogen - hypothetical protein Krad_2464 1 None None None 152965988 Common - short-chain dehydrogenase/reductase SDR Krad_2023 234 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152968268 Common - HhH-GPD family protein Krad_4325 49 COG0122 AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 152967575 Common - Radical SAM domain protein Krad_3632 54 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 152964135 Common - ATP-dependent DNA helicase Krad_0164 33 COG3973 COG3973, Superfamily I DNA and RNA helicases General function prediction only 152966552 Common - two component transcriptional regulator, LuxR family Krad_2599 206 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152966789 Nonpathogen - hypothetical protein Krad_2841 1 None None None 152967786 Common - hypothetical protein Krad_3843 18 None None None 152967871 Common - aldehyde dehydrogenase Krad_3928 69 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 152967752 Common - protein of unknown function DUF1006 Krad_3809 59 COG3214 COG3214, Uncharacterized protein conserved in bacteria Function unknown 152965556 Common - hypothetical protein Krad_1590 5 None None None 152966947 Common - hypothetical protein Krad_3003 10 None None None 152965854 Nonpathogen - hypothetical protein Krad_1888 1 None None None 152966746 Common - ABC transporter-related protein Krad_2796 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 152967162 Common - hypothetical protein Krad_3218 2 None None None 152968184 Common - 2',3'-cyclic-nucleotide 2'-phosphodiesterase Krad_4241 126 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 152967423 Common - glycoside hydrolase family 3 domain protein Krad_3480 115 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 152966433 Common - sodium/hydrogen exchanger Krad_2477 9 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 152967261 Common - methionine aminopeptidase, type I Krad_3317 249 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 152965206 Common - NAD(+) kinase Krad_1238 221 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 152967831 Common - UDP-galactopyranose mutase Krad_3888 57 COG0562 Glf, UDP-galactopyranose mutase Cell envelope biogenesis, outer membrane 152964657 Common - ribosomal protein L3 Krad_0688 216 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 152965384 Common - translation elongation factor Ts Krad_1416 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 152964814 Nonpathogen - hypothetical protein Krad_0846 1 COG2246 COG2246, Predicted membrane protein Function unknown 152964903 Common - aminotransferase class V Krad_0935 225 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 152966005 Common - regulatory protein ArsR Krad_2040 8 COG0640 ArsR, Predicted transcriptional regulators Transcription 152964951 Common - PfkB domain protein Krad_0983 124 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 152965124 Common - type II secretion system protein E Krad_1156 219 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 152966085 Common - basic membrane lipoprotein Krad_2121 100 COG1744 Med, Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein General function prediction only 152964794 Common - DNA-binding protein Krad_0826 13 None None None 152967231 Common - beta-lactamase Krad_3287 99 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 152964236 Common - hypothetical protein Krad_0266 6 None None None 152968011 Common - phosphoribosylformylglycinamidine synthase II Krad_4068 234 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 152965918 Common - glycerol-phosphate porter Krad_1952 9 None None None 152967894 Common - Mannose-1-phosphate guanylyltransferase (GDP) Krad_3951 160 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 152968205 Common - integral membrane sensor signal transduction histidine kinase Krad_4262 78 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152965191 Common - binding-protein-dependent transport systems inner membrane component Krad_1223 172 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 152965333 Common - secreted protein Krad_1365 7 None None None 152965538 Common - NADPH-dependent FMN reductase Krad_1572 101 COG0431 COG0431, Predicted flavoprotein General function prediction only 152968071 Common - FAD dependent oxidoreductase Krad_4128 23 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 152965600 Common - short-chain dehydrogenase/reductase SDR Krad_1634 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152964849 Nonpathogen - hypothetical protein Krad_0881 1 None None None 152965343 Common - ribosomal protein L32 Krad_1375 15 None None None 152966331 Nonpathogen - hypothetical protein Krad_2371 1 None None None 152967732 Common - type II secretion system protein E Krad_3789 179 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 152965799 Common - Phosphoglycerate mutase Krad_1833 35 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 152965008 Common - hypothetical protein Krad_1040 14 None None None 152965083 Common - binding-protein-dependent transport systems inner membrane component Krad_1115 200 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152967617 Nonpathogen - hypothetical protein Krad_3674 2 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152968219 Nonpathogen - putative anti-sigma regulatory factor, serine/threonine protein kinase Krad_4276 2 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152967156 Common - hypothetical protein Krad_3212 15 None None None 152964676 Common - ribosomal protein L15 Krad_0707 219 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 152964033 Nonpathogen - hypothetical protein Krad_0062 1 None None None 152966901 Common - Extracellular ligand-binding receptor Krad_2957 137 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 152967386 Common - leucyl-tRNA synthetase Krad_3443 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152967922 Common - exodeoxyribonuclease III Xth Krad_3979 192 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 152966648 Common - carbonic anhydrase Krad_2696 148 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 152964960 Common - exodeoxyribonuclease V, gamma subunit Krad_0992 59 COG1330 RecC, Exonuclease V gamma subunit DNA replication, recombination, and repair 152966306 Common - NUDIX hydrolase Krad_2346 11 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 152964983 Nonpathogen - hypothetical protein Krad_1015 1 None None None 152967105 Common - N-acetyl-gamma-glutamyl-phosphate reductase Krad_3161 199 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 152964885 Common - TrkA-C domain protein Krad_0917 35 COG0490 COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels Inorganic ion transport and metabolism 152966760 Common - short-chain dehydrogenase/reductase SDR Krad_2810 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152966886 Common - excinuclease ABC, B subunit Krad_2942 224 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 152968223 Common - Ferritin Dps family protein Krad_4280 107 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 152966918 Nonpathogen - hypothetical protein Krad_2974 1 None None None 152966591 Nonpathogen - hypothetical protein Krad_2639 3 None None None 152967735 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Krad_3792 18 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152965189 Common - NAD-dependent epimerase/dehydratase Krad_1221 155 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152967820 Common - LGFP repeat protein Krad_3877 23 COG5479 COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis Cell envelope biogenesis, outer membrane 152965800 Common - hypothetical protein Krad_1834 17 None None None 152967152 Common - MraZ protein Krad_3208 136 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 152964667 Common - ribosomal protein L14 Krad_0698 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 152967187 Common - glycosyl transferase group 1 Krad_3243 204 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152967343 Common - histidine triad (HIT) protein Krad_3399 214 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 152965288 Nonpathogen - hypothetical protein Krad_1320 1 None None None 152964141 Common - glycosyl transferase family 2 Krad_0170 17 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152967683 Nonpathogen - secreted protein Krad_3740 8 None None None 152966704 Common - Methyltransferase type 12 Krad_2752 62 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152966833 Common - putative transcriptional regulator, XRE family Krad_2888 48 COG3655 COG3655, Predicted transcriptional regulator Transcription 152964697 Common - alpha/beta hydrolase fold Krad_0728 134 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152967033 Nonpathogen - VanZ family protein Krad_3089 1 COG4767 VanZ, Glycopeptide antibiotics resistance protein Defense mechanisms 152966151 Common - alpha/beta hydrolase fold Krad_2188 56 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152966440 Common - UspA domain protein Krad_2484 9 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 152967142 Common - UDP-N-acetylmuramate--alanine ligase Krad_3198 207 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 152965481 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Krad_1513 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 152966717 Nonpathogen - hypothetical protein Krad_2766 1 None None None 152965141 Common - phospholipid/glycerol acyltransferase Krad_1173 92 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 152968174 Common - chaperone DnaJ domain protein Krad_4231 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 152967416 Common - hypothetical protein Krad_3473 17 COG4529 COG4529, Uncharacterized protein conserved in bacteria Function unknown 152964277 Common - glycoside hydrolase 15-related Krad_0307 66 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 152966290 Common - conserved hypothetical protein; putative signal peptide Krad_2329 72 COG2843 PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) Cell envelope biogenesis, outer membrane 152967868 Common - phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I Krad_3925 173 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 152967614 Common - glycosyl transferase family 2 Krad_3671 149 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152964805 Common - transcriptional regulator, TetR family Krad_0837 30 COG1309 AcrR, Transcriptional regulator Transcription 152967170 Common - CDP-alcohol phosphatidyltransferase Krad_3226 14 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 152966025 Common - Radical SAM domain protein Krad_2060 48 COG2516 COG2516, Biotin synthase-related enzyme General function prediction only 152966227 Nonpathogen - hypothetical protein Krad_2266 1 None None None 152967390 Common - beta-lactamase Krad_3447 38 COG2367 PenP, Beta-lactamase class A Defense mechanisms 152967704 Common - oxidoreductase molybdopterin binding Krad_3761 128 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 152964685 Common - ribosomal protein L17 Krad_0716 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 152964600 Common - cytochrome c assembly protein Krad_0631 110 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 152965431 Common - Glucose-6-phosphate isomerase Krad_1463 187 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 152964594 Nonpathogen - hypothetical protein Krad_0625 1 None None None 152964515 Common - ABC transporter-related protein Krad_0546 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 152966393 Nonpathogen - hypothetical protein Krad_2433 1 None None None 152964201 Common - Oxidoreductase FAD-binding domain protein Krad_0231 31 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 152966873 Common - Triose-phosphate isomerase Krad_2929 216 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 152967589 Common - putative monooxygenase, DszA family Krad_3646 67 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152965792 Nonpathogen - hypothetical protein Krad_1826 2 None None None 152964003 Common - oxidoreductase domain protein Krad_0031 80 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152963973 Common - chromosomal replication initiator protein DnaA Krad_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 152966893 Common - Methyltransferase type 11 Krad_2949 139 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152966126 Common - transcriptional regulator, DeoR family Krad_2162 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 152964878 Common - Alcohol dehydrogenase zinc-binding domain protein Krad_0910 204 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 152965355 Common - L-rhamnose isomerase Krad_1387 33 COG4952 COG4952, Predicted sugar isomerase Cell envelope biogenesis, outer membrane 152966121 Common - ketose-bisphosphate aldolase Krad_2157 143 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 152964564 Common - ATPase AAA-2 domain protein Krad_0595 230 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 152964183 Nonpathogen - hypothetical protein Krad_0212 2 None None None 152965953 Common - DNA polymerase beta domain protein region Krad_1987 15 COG1708 COG1708, Predicted nucleotidyltransferases General function prediction only 152967102 Common - acetylornithine and succinylornithine aminotransferase Krad_3158 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 152964978 Nonpathogen - APHP domain protein Krad_1010 5 COG1572 COG1572, Uncharacterized conserved protein Function unknown 152967544 Common - aminotransferase class I and II Krad_3601 240 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 152964612 Common - Mandelate racemase/muconate lactonizing protein Krad_0643 80 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 152968447 Common - methyltransferase GidB Krad_4508 201 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 152968143 Common - hypothetical protein Krad_4200 11 COG3358 COG3358, Uncharacterized conserved protein Function unknown 152966798 Nonpathogen - hypothetical protein Krad_2851 1 None None None 152966730 Common - Alcohol dehydrogenase. zinc-binding type 1 Krad_2780 172 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 152965024 Nonpathogen - hypothetical protein Krad_1056 3 None None None 152965256 Common - cysteine dioxygenase type I Krad_1288 7 None None None 152964176 Nonpathogen - branched-chain amino acid transport Krad_0205 1 None None None 152967513 Common - RbsD or FucU transport Krad_3570 7 COG4154 FucU, Fucose dissimilation pathway protein FucU Carbohydrate transport and metabolism 152967739 Common - signal transduction histidine kinase Krad_3796 85 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 152965243 Common - protein of unknown function DUF91 Krad_1275 38 COG1637 COG1637, Predicted nuclease of the RecB family DNA replication, recombination, and repair 152965238 Common - ATP synthase F1, beta subunit Krad_1270 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 152967219 Common - GCN5-related N-acetyltransferase Krad_3275 9 COG0456 RimI, Acetyltransferases General function prediction only 152967715 Common - type III restriction protein res subunit Krad_3772 28 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 152964550 Common - Alanine racemase Krad_0581 126 COG1609 PurR, Transcriptional regulators Transcription 152967913 Common - Beta-galactosidase Krad_3970 39 COG1874 LacA, Beta-galactosidase Carbohydrate transport and metabolism 152964281 Common - Roadblock/LC7 family protein Krad_0311 13 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 152965846 Common - hypothetical protein Krad_1880 43 COG2378 COG2378, Predicted transcriptional regulator Transcription 152965583 Common - YbaK/prolyl-tRNA synthetase associated region Krad_1617 14 COG2606 EbsC, Uncharacterized conserved protein Function unknown 152965479 Common - transcriptional regulator, TraR/DksA family Krad_1511 24 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 152966362 Nonpathogen - hypothetical protein Krad_2402 1 None None None 152967076 Nonpathogen - type II secretion system protein Krad_3132 3 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion 152968340 Common - binding-protein-dependent transport systems inner membrane component Krad_4401 174 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152966987 Common - hypothetical protein Krad_3043 13 None None None 152967039 Common - putative transcriptional regulator, MerR family Krad_3095 20 COG0789 SoxR, Predicted transcriptional regulators Transcription 152964463 Common - Methyltransferase type 11 Krad_0494 20 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152966984 Common - aspartyl-tRNA synthetase Krad_3040 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152965546 Nonpathogen - hypothetical protein Krad_1580 2 None None None 152964244 Common - transcriptional regulator, TetR family Krad_0274 10 COG1309 AcrR, Transcriptional regulator Transcription 152967061 Common - cytidylate kinase Krad_3117 192 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 152964168 Common - 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase Krad_0197 28 COG3717 KduI, 5-keto 4-deoxyuronate isomerase Carbohydrate transport and metabolism 152964923 Nonpathogen - hypothetical protein Krad_0955 1 None None None 152965816 Common - response regulator receiver protein Krad_1850 221 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152965692 Nonpathogen - hypothetical protein Krad_1726 1 None None None 152967304 Common - putative methylase Krad_3360 34 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 152968246 Common - hypothetical protein Krad_4303 13 None None None 152966382 Nonpathogen - hypothetical protein Krad_2422 1 None None None 152967117 Common - bifunctional HisA/TrpF protein Krad_3173 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 152965938 Nonpathogen - hypothetical protein Krad_1972 1 None None None 152967440 Common - FolC bifunctional protein Krad_3497 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 152964348 Nonpathogen - hypothetical protein Krad_0378 1 None None None 152964398 Common - transcription factor WhiB Krad_0428 19 None None None 152966098 Common - hypothetical protein Krad_2134 20 COG2910 COG2910, Putative NADH-flavin reductase General function prediction only 152964761 Nonpathogen - hypothetical protein Krad_0793 1 None None None 152968159 Common - ATPase AAA-2 domain protein Krad_4216 223 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 152965521 Common - hypothetical protein Krad_1555 19 None None None 152965088 Common - hypothetical protein Krad_1120 7 None None None 152965098 Common - protein of unknown function DUF305 Krad_1130 33 COG3544 COG3544, Uncharacterized protein conserved in bacteria Function unknown 152968388 Common - methyl-accepting chemotaxis sensory transducer Krad_4449 157 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152965656 Nonpathogen - hypothetical protein Krad_1690 1 None None None 152964795 Common - radical SAM domain protein Krad_0827 16 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 152967845 Common - peptidase S8 and S53 subtilisin kexin sedolisin Krad_3902 91 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 152966806 Nonpathogen - hypothetical protein Krad_2860 1 None None None 152965775 Common - hypothetical protein Krad_1809 18 COG3864 COG3864, Uncharacterized protein conserved in bacteria Function unknown 152965293 Common - Uroporphyrinogen III synthase HEM4 Krad_1325 27 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 152966050 Common - regulatory protein TetR Krad_2085 15 None None None 152965182 Common - twitching motility protein Krad_1214 212 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 152965906 Common - Alpha/beta hydrolase fold-3 domain protein Krad_1940 131 COG0657 Aes, Esterase/lipase Lipid metabolism 152968068 Common - intracellular protease, PfpI family Krad_4125 140 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 152964662 Common - ribosomal protein L22 Krad_0693 216 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 152965497 Common - protein of unknown function DUF1232 Krad_1529 3 COG3339 COG3339, Uncharacterized conserved protein Function unknown 152967237 Nonpathogen - hypothetical protein Krad_3293 2 None None None 152965455 Common - helix-turn-helix domain protein Krad_1487 19 None None None 152964967 Common - DNA-3-methyladenine glycosylase I Krad_0999 131 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 152966865 Common - protoheme IX farnesyltransferase Krad_2921 175 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 152964253 Common - diguanylate cyclase Krad_0283 168 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152968423 Common - putative transcriptional regulator, PucR family Krad_4484 12 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 152966791 Nonpathogen - hypothetical protein Krad_2843 1 None None None 152964431 Common - uracil-xanthine permease Krad_0461 116 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 152967052 Nonpathogen - hypothetical protein Krad_3108 2 None None None 152967929 Common - CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase Krad_3986 34 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 152966399 Nonpathogen - hypothetical protein Krad_2440 1 COG5466 COG5466, Predicted small metal-binding protein Function unknown 152967184 Nonpathogen - hypothetical protein Krad_3240 1 None None None 152964005 Common - hypothetical protein Krad_0033 83 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 152965474 Common - SOS-response transcriptional repressor, LexA Krad_1506 171 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 152964789 Common - RNA polymerase, sigma 28 subunit, FliA/WhiG family Krad_0821 164 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 152967487 Common - diguanylate cyclase/phosphodiesterase Krad_3544 177 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152966008 Common - transcriptional regulator, MarR family Krad_2043 31 COG1846 MarR, Transcriptional regulators Transcription 152966678 Common - isochorismatase hydrolase Krad_2726 66 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 152967132 Common - pseudouridine synthase, RluA family Krad_3188 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 152965964 Common - integral membrane sensor signal transduction histidine kinase Krad_1999 26 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152965227 Common - modification methylase, HemK family Krad_1259 213 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 152965284 Common - amidinotransferase Krad_1316 38 COG1834 COG1834, N-Dimethylarginine dimethylaminohydrolase Amino acid transport and metabolism 152964623 Common - hypothetical protein Krad_0654 31 COG3395 COG3395, Uncharacterized protein conserved in bacteria Function unknown 152968196 Common - putative NHL repeat protein Krad_4253 36 None None None 152966972 Common - LGFP repeat protein Krad_3028 12 COG5479 COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis Cell envelope biogenesis, outer membrane 152966055 Common - extracellular solute-binding protein family 1 Krad_2090 69 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152967320 Common - diguanylate cyclase Krad_3376 170 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152966657 Common - regulatory protein LacI Krad_2705 71 COG1609 PurR, Transcriptional regulators Transcription 152967168 Common - glycosyl transferase family 2 Krad_3224 38 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152967522 Common - Haloacid dehalogenase domain protein hydrolase Krad_3579 8 COG0546 Gph, Predicted phosphatases General function prediction only 152966387 Common - alpha/beta hydrolase fold Krad_2427 88 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152965427 Common - ABC transporter-related protein Krad_1459 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 152964383 Common - glycoside hydrolase family 31 Krad_0413 82 COG1501 COG1501, Alpha-glucosidases, family 31 of glycosyl hydrolases Carbohydrate transport and metabolism 152965702 Nonpathogen - hypothetical protein Krad_1736 1 None None None 152966079 Common - hypothetical protein Krad_2114 3 None None None 152964323 Common - putative cold-shock DNA-binding domain protein Krad_0353 23 COG1278 CspC, Cold shock proteins Transcription 152967895 Common - Succinate dehydrogenase cytochrome b556 subunit Krad_3952 14 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 152965715 Nonpathogen - hypothetical protein Krad_1749 1 None None None 152966530 Common - helix-turn-helix domain protein Krad_2575 39 None None None 152964871 Common - hypothetical protein Krad_0903 49 COG3665 COG3665, Uncharacterized conserved protein Function unknown 152967442 Common - glycosyl transferase family 2 Krad_3499 78 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152966262 Nonpathogen - hypothetical protein Krad_2301 1 None None None 152967637 Common - putative regulatory protein, FmdB family Krad_3694 72 COG2331 COG2331, Uncharacterized protein conserved in bacteria Function unknown 152967360 Nonpathogen - hypothetical protein Krad_3416 1 None None None 152964105 Nonpathogen - aldo/keto reductase Krad_0134 10 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152965528 Common - TrkA-N domain protein Krad_1562 130 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 152967065 Common - putative transcriptional regulator Krad_3121 141 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 152967876 Common - hypothetical protein Krad_3933 8 None None None 152967600 Nonpathogen - hypothetical protein Krad_3657 1 None None None 152964481 Nonpathogen - hypothetical protein Krad_0512 1 None None None 152964547 Common - hypothetical protein Krad_0578 17 None None None 152966611 Common - integral membrane sensor signal transduction histidine kinase Krad_2659 84 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152964125 Nonpathogen - putative integral membrane protein Krad_0154 1 None None None 152966650 Nonpathogen - major facilitator superfamily MFS_1 Krad_2698 1 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 152968214 Common - methyl-accepting chemotaxis sensory transducer Krad_4271 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152965633 Common - export protein FliQ family 3 Krad_1667 111 COG1987 FliQ, Flagellar biosynthesis pathway, component FliQ Cell motility and secretion / Intracellular trafficking and secretion 152966741 Common - GCN5-related N-acetyltransferase Krad_2791 71 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 152966840 Nonpathogen - hypothetical protein Krad_2896 1 None None None 152966567 Common - protein of unknown function DUF1016 Krad_2614 35 COG4804 COG4804, Uncharacterized conserved protein Function unknown 152964524 Common - sulphate transporter Krad_0555 149 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 152965289 Common - Putative protein-S-isoprenylcysteine methyltransferase-like protein Krad_1321 26 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 152967791 Common - histidine kinase HAMP region domain protein Krad_3848 9 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152965145 Common - hypothetical protein Krad_1177 9 None None None 152965348 Common - extracellular solute-binding protein family 1 Krad_1380 56 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152968006 Common - aminoglycoside phosphotransferase Krad_4063 20 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 152968330 Nonpathogen - hypothetical protein Krad_4388 1 None None None 152967031 Common - band 7 protein Krad_3087 219 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 152967693 Common - transcriptional regulator, LysR family Krad_3750 171 COG0583 LysR, Transcriptional regulator Transcription 152966478 Common - putative ferredoxin Krad_2523 4 COG1141 Fer, Ferredoxin Energy production and conversion 152967202 Common - Cytochrome c oxidase subunit I type Krad_3258 163 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 152968153 Common - major facilitator superfamily MFS_1 Krad_4210 119 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 152966204 Nonpathogen - hypothetical protein Krad_2243 4 None None None 152968050 Common - hypothetical protein Krad_4107 12 None None None 152967332 Common - protein of unknown function DUF72 Krad_3388 104 COG1801 COG1801, Uncharacterized conserved protein Function unknown 152964426 Nonpathogen - hypothetical protein Krad_0456 1 None None None 152964580 Common - histone deacetylase superfamily Krad_0611 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 152966702 Common - pyridine nucleotide-disulphide oxidoreductase dimerisation region Krad_2750 240 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 152965851 Common - DEAD/DEAH box helicase domain protein Krad_1885 109 COG4581 COG4581, Superfamily II RNA helicase DNA replication, recombination, and repair 152964652 Common - ribosomal protein S7 Krad_0683 245 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 152965504 Common - PfkB domain protein Krad_1536 89 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 152965665 Nonpathogen - hypothetical protein Krad_1699 4 None None None 152967229 Common - glycosyl transferase family 2 Krad_3285 188 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152968084 Nonpathogen - hypothetical protein Krad_4141 1 None None None 152966297 Common - histone family protein DNA-binding protein Krad_2337 205 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 152966480 Common - short-chain dehydrogenase/reductase SDR Krad_2525 233 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152965642 Nonpathogen - hypothetical protein Krad_1676 1 None None None 152967679 Common - hypothetical protein Krad_3736 5 None None None 152966278 Common - aldo/keto reductase Krad_2317 196 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 152967189 Common - hypothetical protein Krad_3245 5 None None None 152964898 Common - hypothetical protein Krad_0930 11 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 152964672 Common - ribosomal protein L6 Krad_0703 246 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 152967748 Common - hypothetical protein Krad_3805 5 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 152968275 Common - modification methylase, HemK family Krad_4332 95 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 152967647 Common - transport system permease protein Krad_3704 36 COG4605 CeuC, ABC-type enterochelin transport system, permease component Inorganic ion transport and metabolism 152964378 Common - glycoside hydrolase family 3 domain protein Krad_0408 81 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 152966479 Common - cytochrome P450 Krad_2524 69 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 152965113 Nonpathogen - hypothetical protein Krad_1145 2 None None None 152966038 Common - transcriptional regulator, PucR family Krad_2073 5 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 152967374 Nonpathogen - hypothetical protein Krad_3431 2 COG1896 COG1896, Predicted hydrolases of HD superfamily General function prediction only 152966407 Nonpathogen - hypothetical protein Krad_2448 2 None None None 152967397 Common - glutamate 5-kinase Krad_3454 187 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 152966271 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_2310 81 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152967841 Nonpathogen - hypothetical protein Krad_3898 1 COG2456 COG2456, Uncharacterized conserved protein Function unknown 152965825 Common - oxidoreductase domain protein Krad_1859 110 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152967258 Nonpathogen - hypothetical protein Krad_3314 3 None None None 152966377 Common - putative transcriptional regulator, MerR family Krad_2417 8 COG0789 SoxR, Predicted transcriptional regulators Transcription 152965134 Common - DEAD/DEAH box helicase domain protein Krad_1166 237 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 152966821 Common - hypothetical protein Krad_2875 11 COG3828 COG3828, Uncharacterized protein conserved in bacteria Function unknown 152966527 Common - transcriptional regulator, TetR family Krad_2572 31 COG1309 AcrR, Transcriptional regulator Transcription 152965305 Common - ketol-acid reductoisomerase Krad_1337 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 152966869 Common - OpcA protein Krad_2925 23 COG3429 COG3429, Glucose-6-P dehydrogenase subunit Carbohydrate transport and metabolism 152966848 Common - 3-oxoacyl-(acyl-carrier-protein) reductase Krad_2904 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152965108 Common - citrate synthase I Krad_1140 194 COG0372 GltA, Citrate synthase Energy production and conversion 152966715 Nonpathogen - hypothetical protein Krad_2764 1 None None None 152964394 Common - putative transcriptional regulator, Crp/Fnr family Krad_0424 160 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 152965543 Nonpathogen - hypothetical protein Krad_1577 1 None None None 152964085 Common - periplasmic binding protein/LacI transcriptional regulator Krad_0114 124 COG1609 PurR, Transcriptional regulators Transcription 152967518 Nonpathogen - copper resistance protein CopC Krad_3575 2 COG2372 CopC, Uncharacterized protein, homolog of Cu resistance protein CopC General function prediction only 152967224 Common - domain of unknown function DUF1731 Krad_3280 105 COG1090 COG1090, Predicted nucleoside-diphosphate sugar epimerase General function prediction only 152966233 Common - Integrase catalytic region Krad_2272 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 152965935 Common - Serine-type D-Ala-D-Ala carboxypeptidase Krad_1969 110 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 152964295 Common - response regulator receiver protein Krad_0325 203 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152967902 Common - Formaldehyde dehydrogenase glutathione-independent Krad_3959 181 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 152965864 Nonpathogen - hypothetical protein Krad_1898 2 COG5466 COG5466, Predicted small metal-binding protein Function unknown 152967640 Common - hypothetical protein Krad_3697 7 COG4581 COG4581, Superfamily II RNA helicase DNA replication, recombination, and repair 152967002 Common - SNO glutamine amidotransferase Krad_3058 85 COG0311 PDX2, Predicted glutamine amidotransferase involved in pyridoxine biosynthesis Coenzyme metabolism 152966542 Nonpathogen - hypothetical protein Krad_2588 1 None None None 152967351 Common - hypothetical protein Krad_3407 15 None None None 152967358 Common - hypothetical protein Krad_3414 5 COG1990 COG1990, Uncharacterized conserved protein Function unknown 152966072 Nonpathogen - anti-sigma-factor antagonist Krad_2107 1 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 152966313 Nonpathogen - hypothetical protein Krad_2353 1 None None None 152966614 Common - MMPL domain protein Krad_2662 64 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 152967437 Common - hypothetical protein Krad_3494 4 None None None 152967017 Common - glycogen debranching enzyme GlgX Krad_3073 150 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 152965875 Common - dihydroxy-acid dehydratase Krad_1909 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 152965507 Common - Carboxylesterase type B Krad_1541 102 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 152968253 Common - transcriptional regulator, TrmB Krad_4310 41 COG0640 ArsR, Predicted transcriptional regulators Transcription 152968449 Common - 60 kDa inner membrane insertion protein Krad_4510 214 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 152966515 Nonpathogen - hypothetical protein Krad_2560 1 None None None 152965393 Common - aldehyde dehydrogenase Krad_1425 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 152967597 Common - periplasmic binding protein Krad_3654 82 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 152968361 Common - ABC transporter-related protein Krad_4422 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 152964310 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Krad_0340 230 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 152967253 Common - Uncharacterized protein involved in stress response-like protein Krad_3309 10 COG4110 COG4110, Uncharacterized protein involved in stress response General function prediction only 152968048 Common - Siderophore-interacting protein Krad_4105 62 COG2375 ViuB, Siderophore-interacting protein Inorganic ion transport and metabolism 152967159 Common - DNA polymerase III, alpha subunit Krad_3215 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 152964934 Common - glycoside hydrolase family 2 sugar binding Krad_0966 69 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 152967116 Common - hypothetical protein Krad_3172 9 None None None 152966755 Common - histone family protein DNA-binding protein Krad_2805 206 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 152967996 Common - inner-membrane translocator Krad_4053 114 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 152965414 Nonpathogen - hypothetical protein Krad_1446 1 None None None 152967627 Nonpathogen - hypothetical protein Krad_3684 2 None None None 152964888 Common - Alpha,alpha-trehalose-phosphate synthase (UDP-forming) Krad_0920 97 COG0380 OtsA, Trehalose-6-phosphate synthase Carbohydrate transport and metabolism 152964365 Common - hypothetical protein Krad_0395 25 COG1511 COG1511, Predicted membrane protein Function unknown 152965257 Common - phenylalanine/histidine ammonia-lyase Krad_1289 104 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 152968101 Common - diguanylate phosphodiesterase Krad_4158 170 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152964212 Common - hypothetical protein Krad_0242 11 None None None 152966711 Nonpathogen - Domain of unknown function DUF1801 Krad_2759 4 COG5649 COG5649, Uncharacterized conserved protein Function unknown 152965907 Nonpathogen - peptidase domain protein Krad_1941 1 None None None 152964779 Nonpathogen - hypothetical protein Krad_0811 2 None None None 152964309 Nonpathogen - diacylglycerol kinase catalytic region Krad_0339 8 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 152965594 Common - flagellar protein FliS Krad_1628 10 COG1516 FliS, Flagellin-specific chaperone FliS Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 152965363 Common - metal dependent phosphohydrolase Krad_1395 119 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 152968383 Common - glycosyl transferase group 1 Krad_4444 59 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152967756 Common - hypothetical protein Krad_3813 14 COG5401 COG5401, Spore germination protein General function prediction only 152967620 Nonpathogen - hypothetical protein Krad_3677 1 None None None 152968023 Common - protein serine phosphatase with GAF(s) sensor(s) Krad_4080 81 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152967904 Common - Beta-glucosidase Krad_3961 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 152964689 Common - ribosomal protein L13 Krad_0720 235 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 152964731 Nonpathogen - hypothetical protein Krad_0762 1 None None None 152964095 Common - Endonuclease/exonuclease/phosphatase Krad_0124 3 COG3021 COG3021, Uncharacterized protein conserved in bacteria Function unknown 152967430 Common - putative oxygenase Krad_3487 50 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152965740 Nonpathogen - hypothetical protein Krad_1774 1 None None None 152968322 Nonpathogen - hypothetical protein Krad_4379 2 None None None 152964360 Common - oxidoreductase domain protein Krad_0390 162 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152966828 Common - 3-oxoacid CoA-transferase, B subunit Krad_2883 97 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 152967975 Nonpathogen - hypothetical protein Krad_4032 1 None None None 152964418 Nonpathogen - hypothetical protein Krad_0448 1 None None None 152967149 Common - Peptidoglycan glycosyltransferase Krad_3205 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 152966215 Nonpathogen - hypothetical protein Krad_2254 1 None None None 152968363 Common - glutamine synthetase catalytic region Krad_4424 184 COG3968 COG3968, Uncharacterized protein related to glutamine synthetase General function prediction only 152968433 Common - polynucleotide adenylyltransferase/metal dependent phosphohydrolase Krad_4494 211 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 152968036 Common - LrgB family protein Krad_4093 84 COG1346 LrgB, Putative effector of murein hydrolase Cell envelope biogenesis, outer membrane 152967276 Common - transcriptional regulator, MarR family Krad_3332 35 COG1846 MarR, Transcriptional regulators Transcription 152964287 Nonpathogen - hypothetical protein Krad_0317 1 None None None 152964540 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Krad_0571 166 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 152967083 Common - phage integrase family protein Krad_3139 222 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 152965786 Common - lipopolysaccharide biosynthesis protein Krad_1820 8 COG3944 COG3944, Capsular polysaccharide biosynthesis protein Cell envelope biogenesis, outer membrane 152967950 Common - GCN5-related N-acetyltransferase Krad_4007 22 COG3393 COG3393, Predicted acetyltransferase General function prediction only 152966666 Common - hypothetical protein Krad_2714 18 COG4925 COG4925, Uncharacterized conserved protein Function unknown 152967851 Common - biotin--acetyl-CoA-carboxylase ligase Krad_3908 196 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 152968379 Common - hypothetical protein Krad_4440 3 None None None 152964142 Nonpathogen - hypothetical protein Krad_0171 1 COG4346 COG4346, Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase Posttranslational modification, protein turnover, chaperones 152964863 Common - histidine kinase Krad_0895 201 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 152964852 Common - glycine cleavage T protein (aminomethyl transferase) Krad_0884 96 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 152964342 Nonpathogen - hypothetical protein Krad_0372 1 None None None 152966936 Common - Guanylate kinase Krad_2992 213 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 152968033 Common - binding-protein-dependent transport systems inner membrane component Krad_4090 140 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 152966416 Common - methyl-accepting chemotaxis sensory transducer Krad_2460 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152967582 Common - Uracil-DNA glycosylase superfamily Krad_3639 128 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 152965246 Common - hypothetical protein Krad_1278 22 COG2945 COG2945, Predicted hydrolase of the alpha/beta superfamily General function prediction only 152967957 Common - Alanine racemase Krad_4014 126 COG1609 PurR, Transcriptional regulators Transcription 152964219 Common - seryl-tRNA synthetase Krad_0249 243 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 152964827 Common - OsmC family protein Krad_0859 75 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 152967099 Common - argininosuccinate lyase Krad_3155 219 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 152965341 Common - hypothetical protein Krad_1373 8 None None None 152966508 Common - SMC domain protein Krad_2553 54 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 152964069 Common - putative PAS/PAC sensor protein Krad_0098 149 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152965353 Common - carbohydrate kinase FGGY Krad_1385 95 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 152964056 Common - L-amino-acid oxidase Krad_0085 36 COG1231 COG1231, Monoamine oxidase Amino acid transport and metabolism 152967571 Common - FAD dependent oxidoreductase Krad_3628 51 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 152965279 Common - hypothetical protein Krad_1311 15 None None None 152965324 Common - glutamyl-tRNA synthetase Krad_1356 247 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 152966495 Common - oxidoreductase domain protein Krad_2540 39 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152966720 Nonpathogen - hypothetical protein Krad_2769 1 None None None 152964914 Nonpathogen - hypothetical protein Krad_0946 1 None None None 152966185 Common - Alcohol dehydrogenase zinc-binding domain protein Krad_2224 203 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 152964820 Common - Hydroxyethylthiazole kinase Krad_0852 75 COG2145 ThiM, Hydroxyethylthiazole kinase, sugar kinase family Coenzyme metabolism 152964521 Common - proline-specific peptidase Krad_0552 124 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152965068 Common - hypothetical protein Krad_1100 5 None None None 152967092 Common - ATP-NAD/AcoX kinase Krad_3148 238 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 152966105 Nonpathogen - hypothetical protein Krad_2141 9 COG1649 COG1649, Uncharacterized protein conserved in bacteria Function unknown 152967549 Common - fatty acid desaturase Krad_3606 30 COG3239 DesA, Fatty acid desaturase Lipid metabolism 152967525 Common - hypothetical protein Krad_3582 6 None None None 152965553 Common - Chlorite dismutase Krad_1587 34 COG3253 COG3253, Uncharacterized conserved protein Function unknown 152965914 Nonpathogen - hypothetical protein Krad_1948 1 None None None 152967213 Common - major facilitator superfamily MFS_1 Krad_3269 130 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 152966609 Common - Alpha/beta hydrolase fold-3 domain protein Krad_2657 78 COG0657 Aes, Esterase/lipase Lipid metabolism 152967291 Common - hypothetical protein Krad_3347 17 None None None 152967296 Common - iron permease FTR1 Krad_3352 33 COG0672 FTR1, High-affinity Fe2+/Pb2+ permease Inorganic ion transport and metabolism 152968284 Common - glycosyl transferase family 51 Krad_4341 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 152965993 Nonpathogen - hypothetical protein Krad_2028 1 COG1963 COG1963, Uncharacterized protein conserved in bacteria Function unknown 152965061 Common - major facilitator superfamily MFS_1 Krad_1093 74 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152968402 Common - diguanylate cyclase/phosphodiesterase Krad_4463 166 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152967953 Common - sodium/hydrogen exchanger Krad_4010 47 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 152964234 Nonpathogen - hypothetical protein Krad_0264 1 None None None 152966902 Common - response regulator receiver and ANTAR domain protein Krad_2958 221 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 152967265 Nonpathogen - hypothetical protein Krad_3321 1 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 152965900 Common - diguanylate cyclase/phosphodiesterase Krad_1934 174 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152968398 Common - Alcohol dehydrogenase zinc-binding domain protein Krad_4459 194 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 152966170 Common - Alcohol dehydrogenase GroES domain protein Krad_2209 166 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 152966537 Nonpathogen - hypothetical protein Krad_2583 1 None None None 152966193 Nonpathogen - hypothetical protein Krad_2232 9 None None None 152966392 Nonpathogen - hypothetical protein Krad_2432 1 None None None 152964024 Common - hypothetical protein Krad_0053 88 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 152967993 Common - Xylose isomerase domain protein TIM barrel Krad_4050 31 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 152965043 Common - protein of unknown function DUF501 Krad_1075 26 COG1507 COG1507, Uncharacterized conserved protein Function unknown 152966978 Common - hypothetical protein Krad_3034 11 None None None 152964040 Common - UspA domain protein Krad_0069 25 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 152965975 Common - diguanylate phosphodiesterase Krad_2010 170 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152965512 Common - DNA topoisomerase (ATP-hydrolyzing) Krad_1546 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 152965017 Common - transcriptional regulator, MarR family Krad_1049 36 COG1846 MarR, Transcriptional regulators Transcription 152966684 Nonpathogen - hypothetical protein Krad_2732 1 None None None 152966767 Nonpathogen - hypothetical protein Krad_2817 1 None None None 152964474 Common - integral membrane sensor signal transduction histidine kinase Krad_0505 76 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 152966923 Common - riboflavin synthase, alpha subunit Krad_2979 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 152965998 Nonpathogen - hypothetical protein Krad_2033 1 None None None 152966776 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Krad_2828 152 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 152966364 Common - helix-turn-helix- domain containing protein AraC type Krad_2404 62 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 152965754 Common - protein of unknown function DUF81 Krad_1788 110 COG0730 COG0730, Predicted permeases General function prediction only 152968403 Common - hypothetical protein Krad_4464 8 None None None 152964716 Common - ABC transporter-related protein Krad_0747 248 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 152966152 Common - transcriptional regulator, TetR family Krad_2189 101 COG1309 AcrR, Transcriptional regulator Transcription 152966001 Common - short-chain dehydrogenase/reductase SDR Krad_2036 201 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152965891 Nonpathogen - hypothetical protein Krad_1925 1 None None None 152967024 Common - Fe-S metabolism associated SufE Krad_3080 31 COG2166 COG2166, SufE protein probably involved in Fe-S center assembly General function prediction only 152965401 Common - putative agmatinase Krad_1433 136 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 152964486 Common - two component transcriptional regulator, Fis family Krad_0517 50 COG4565 CitB, Response regulator of citrate/malate metabolism Transcription / Signal transduction mechanisms 152966047 Common - transcriptional regulator, TetR family Krad_2082 15 COG1309 AcrR, Transcriptional regulator Transcription 152967176 Common - protein kinase Krad_3232 160 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 152964490 Common - PRC-barrel domain protein Krad_0521 10 COG3861 COG3861, Uncharacterized protein conserved in bacteria Function unknown 152968349 Nonpathogen - hypothetical protein Krad_4410 1 None None None 152964678 Common - adenylate kinase Krad_0709 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 152966165 Common - hypothetical protein Krad_2204 30 None None None 152966090 Nonpathogen - hypothetical protein Krad_2126 1 None None None 152965463 Common - polar amino acid ABC transporter, inner membrane subunit Krad_1495 173 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 152965749 Common - putative cell wall binding repeat 2-containing protein Krad_1783 5 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 152966136 Common - extracellular solute-binding protein family 5 Krad_2173 197 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 152966550 Common - short-chain dehydrogenase/reductase SDR Krad_2597 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152968217 Common - 6-phosphofructokinase Krad_4274 161 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 152964740 Common - N-acetylglucosamine-6-phosphate deacetylase Krad_0772 116 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 152966506 Nonpathogen - hypothetical protein Krad_2551 1 None None None 152967309 Common - putative TIM-barrel protein, nifR3 family Krad_3365 207 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 152967534 Common - putative phosphoserine aminotransferase Krad_3591 123 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 152967107 Common - phenylalanyl-tRNA synthetase, beta subunit Krad_3163 220 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 152966083 Common - transcriptional regulator, MarR family Krad_2118 4 COG1846 MarR, Transcriptional regulators Transcription 152966993 Common - Adenine phosphoribosyltransferase Krad_3049 165 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 152965171 Common - MscS Mechanosensitive ion channel Krad_1203 43 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 152965378 Common - protein of unknown function UPF0027 Krad_1410 121 COG1690 RtcB, Uncharacterized conserved protein Function unknown 152964723 Common - NUDIX hydrolase Krad_0754 20 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 152967271 Common - protein of unknown function DUF328 Krad_3327 16 COG3022 COG3022, Uncharacterized protein conserved in bacteria Function unknown 152967750 Common - preprotein translocase, SecA subunit Krad_3807 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 152967873 Common - transcriptional regulator, MarR family Krad_3930 65 COG1846 MarR, Transcriptional regulators Transcription 152965703 Nonpathogen - hypothetical protein Krad_1737 1 None None None 152966744 Nonpathogen - aminoglycoside phosphotransferase Krad_2794 1 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 152966500 Common - extracellular solute-binding protein family 1 Krad_2545 54 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152964114 Common - phosphoglucomutase, alpha-D-glucose phosphate-specific Krad_0143 175 COG0033 Pgm, Phosphoglucomutase Carbohydrate transport and metabolism 152967784 Common - Phosphomannomutase Krad_3841 242 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 152968251 Common - hypothetical protein Krad_4308 8 None None None 152967918 Common - ABC transporter-related protein Krad_3975 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 152967830 Common - glycosyl transferase family 2 Krad_3887 22 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 152964585 Common - CoA-binding domain protein Krad_0616 56 COG2344 COG2344, AT-rich DNA-binding protein General function prediction only 152966574 Common - Alcohol dehydrogenase GroES domain protein Krad_2621 189 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 152965123 Common - protein of unknown function DUF59 Krad_1155 229 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 152965286 Common - glutamyl-tRNA(Gln) amidotransferase, A subunit Krad_1318 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 152966925 Common - FMN-dependent alpha-hydroxy acid dehydrogenase Krad_2981 110 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 152967436 Common - sugar transporter Krad_3493 120 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152966279 Common - ThiJ/PfpI domain protein Krad_2318 154 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 152964358 Common - protein of unknown function DUF1037 Krad_0388 19 COG4813 ThuA, Trehalose utilization protein Carbohydrate transport and metabolism 152966183 Nonpathogen - hypothetical protein Krad_2222 1 None None None 152965208 Common - transport system permease protein Krad_1240 136 COG4779 FepG, ABC-type enterobactin transport system, permease component Inorganic ion transport and metabolism 152966220 Nonpathogen - hypothetical protein Krad_2259 3 None None None 152965926 Nonpathogen - hypothetical protein Krad_1960 1 None None None 152967555 Common - helicase domain protein Krad_3612 71 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 152965856 Common - apolipoprotein N-acyltransferase Krad_1890 151 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 152965554 Nonpathogen - hypothetical protein Krad_1588 1 None None None 152965788 Nonpathogen - hypothetical protein Krad_1822 1 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 152965331 Common - D-alanine--D-alanine ligase Krad_1363 211 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 152967850 Common - GtrA family protein Krad_3907 19 COG2246 COG2246, Predicted membrane protein Function unknown 152964840 Common - phosphate ABC transporter, ATPase subunit Krad_0872 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 152965217 Nonpathogen - protein of unknown function DUF1345 Krad_1249 1 COG4291 COG4291, Predicted membrane protein Function unknown 152965985 Nonpathogen - hypothetical protein Krad_2020 1 None None None 152967302 Common - hypothetical protein Krad_3358 17 None None None 152967233 Common - integral membrane protein Krad_3289 19 None None None 152966765 Nonpathogen - hypothetical protein Krad_2815 1 None None None 152966838 Common - transcriptional regulator, MarR family Krad_2894 57 COG1846 MarR, Transcriptional regulators Transcription 152966513 Nonpathogen - hypothetical protein Krad_2558 1 None None None 152966141 Common - putative transcriptional regulator, AsnC family Krad_2178 125 COG1522 Lrp, Transcriptional regulators Transcription 152964035 Common - response regulator receiver Krad_0064 182 COG4565 CitB, Response regulator of citrate/malate metabolism Transcription / Signal transduction mechanisms 152966459 Nonpathogen - hypothetical protein Krad_2504 1 None None None 152967688 Common - protein of unknown function DUF161 Krad_3745 32 COG1284 COG1284, Uncharacterized conserved protein Function unknown 152966686 Common - hypothetical protein Krad_2734 14 None None None 152966524 Nonpathogen - hypothetical protein Krad_2569 1 None None None 152964812 Common - Excalibur domain protein Krad_0844 2 COG3889 COG3889, Predicted solute binding protein General function prediction only 152964214 Common - transcription factor WhiB Krad_0244 19 None None None 152968370 Common - amino acid permease-associated region Krad_4431 141 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 152964664 Common - ribosomal protein L16 Krad_0695 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 152965049 Nonpathogen - hypothetical protein Krad_1081 1 None None None 152967073 Nonpathogen - TadE family protein Krad_3129 1 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 152967328 Common - GTP-binding protein Era Krad_3384 216 COG1159 Era, GTPase General function prediction only 152967605 Nonpathogen - Capsular polysaccharide biosynthesis protein-like protein Krad_3662 11 COG4421 COG4421, Capsular polysaccharide biosynthesis protein Carbohydrate transport and metabolism 152964193 Common - Rhodanese domain protein Krad_0222 75 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152965159 Common - PDZ/DHR/GLGF domain protein Krad_1191 38 COG3480 SdrC, Predicted secreted protein containing a PDZ domain Signal transduction mechanisms 152965290 Common - glucose sorbosone dehydrogenase Krad_1322 121 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 152964075 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Krad_0104 9 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152968244 Nonpathogen - putative transmembrane protein Krad_4301 1 None None None 152964755 Nonpathogen - hypothetical protein Krad_0787 1 None None None 152964894 Common - extracellular solute-binding protein family 3 Krad_0926 123 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 152968354 Common - HNH nuclease Krad_4415 10 None None None 152964496 Common - D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase Krad_0527 21 COG2027 DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) Cell envelope biogenesis, outer membrane 152967771 Common - AAA ATPase central domain protein Krad_3828 249 COG1222 RPT1, ATP-dependent 26S proteasome regulatory subunit Posttranslational modification, protein turnover, chaperones 152965620 Nonpathogen - hypothetical protein Krad_1654 1 None None None 152965178 Common - DoxX family protein Krad_1210 13 COG2259 COG2259, Predicted membrane protein Function unknown 152967178 Common - 6-phosphofructokinase Krad_3234 161 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 152964493 Common - SMP-30/Gluconolaconase/LRE domain protein Krad_0524 82 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 152966762 Common - hypothetical protein Krad_2812 3 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 152967047 Common - heat shock protein Hsp20 Krad_3103 120 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 152965580 Common - tRNA/rRNA methyltransferase (SpoU) Krad_1614 206 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 152965765 Common - aminoglycoside phosphotransferase Krad_1799 19 COG3231 Aph, Aminoglycoside phosphotransferase Translation, ribosomal structure and biogenesis 152965575 Common - selenocysteine-specific translation elongation factor Krad_1609 133 COG3276 SelB, Selenocysteine-specific translation elongation factor Translation, ribosomal structure and biogenesis 152967042 Common - protein of unknown function DUF881 Krad_3098 25 COG3879 COG3879, Uncharacterized protein conserved in bacteria Function unknown 152966598 Nonpathogen - hypothetical protein Krad_2646 1 None None None 152964571 Common - protein of unknown function DUF147 Krad_0602 28 COG1623 COG1623, Predicted nucleic-acid-binding protein (contains the HHH domain) General function prediction only 152966469 Nonpathogen - hypothetical protein Krad_2514 1 None None None 152965595 Nonpathogen - hypothetical protein Krad_1629 2 None None None 152967268 Nonpathogen - transcriptional regulator, TetR family Krad_3324 3 COG1309 AcrR, Transcriptional regulator Transcription 152967883 Common - intradiol ring-cleavage dioxygenase Krad_3940 29 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 152968419 Nonpathogen - hypothetical protein Krad_4480 1 None None None 152965084 Common - ABC transporter-related protein Krad_1116 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 152968314 Nonpathogen - hypothetical protein Krad_4371 1 None None None 152964042 Common - metallophosphoesterase Krad_0071 59 COG1409 Icc, Predicted phosphohydrolases General function prediction only 152966671 Common - major facilitator superfamily MFS_1 Krad_2719 132 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152965196 Common - 2-oxoglutarate dehydrogenase, E1 subunit Krad_1228 194 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 152966087 Common - inner-membrane translocator Krad_2123 38 COG4603 COG4603, ABC-type uncharacterized transport system, permease component General function prediction only 152965628 Nonpathogen - flagellar basal body-associated protein FliL Krad_1662 1 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 152965130 Common - hypothetical protein Krad_1162 6 None None None 152965137 Common - Methylated-DNA-(protein)-cysteine S-methyltransferase DNA binding Krad_1169 30 COG3695 COG3695, Predicted methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 152964313 Common - Helix-turn-helix type 11 domain protein Krad_0343 31 COG2378 COG2378, Predicted transcriptional regulator Transcription 152966554 Common - Abortive infection protein Krad_2601 32 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 152965067 Common - transcription elongation factor GreA Krad_1099 204 COG0782 GreA, Transcription elongation factor Transcription 152966206 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Krad_2245 23 None None None 152963995 Common - Rhomboid family protein Krad_0023 34 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 152965020 Common - ribose-phosphate pyrophosphokinase Krad_1052 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 152966464 Common - hypothetical protein Krad_2509 2 None None None 152964919 Common - beta-lactamase Krad_0951 35 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 152965472 Common - helicase c2 Krad_1504 119 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 152967909 Nonpathogen - hypothetical protein Krad_3966 4 None None None 152964617 Common - geranylgeranyl reductase Krad_0648 121 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 152964107 Common - transcriptional regulator, TetR family Krad_0136 37 COG1309 AcrR, Transcriptional regulator Transcription 152966210 Nonpathogen - hypothetical protein Krad_2249 1 None None None 152967789 Common - hypothetical protein Krad_3846 6 None None None 152965581 Common - Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) Krad_1615 200 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 152966780 Nonpathogen - hypothetical protein Krad_2832 2 None None None 152966695 Common - hypothetical protein Krad_2743 5 None None None 152968200 Common - secreted protein Krad_4257 7 COG2509 COG2509, Uncharacterized FAD-dependent dehydrogenases General function prediction only 152967650 Nonpathogen - hypothetical protein Krad_3707 1 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 152967380 Common - regulatory protein LuxR Krad_3437 41 COG3899 COG3899, Predicted ATPase General function prediction only 152967587 Common - transcriptional regulator, LysR family Krad_3644 158 COG0583 LysR, Transcriptional regulator Transcription 152966112 Nonpathogen - hypothetical protein Krad_2148 1 None None None 152964178 Common - protein serine phosphatase with GAF(s) sensor(s) Krad_0207 30 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152964531 Nonpathogen - hypothetical protein Krad_0562 4 None None None 152966035 Common - Transthyretin Krad_2070 60 COG2351 COG2351, Transthyretin-like protein General function prediction only 152964410 Common - ABC transporter-related protein Krad_0440 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 152965569 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Krad_1603 157 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 152964602 Common - peptidase S51 dipeptidase E Krad_0633 20 COG3340 PepE, Peptidase E Amino acid transport and metabolism 152967699 Nonpathogen - hypothetical protein Krad_3756 1 None None None 152964459 Common - dTMP kinase Krad_0489 234 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 152964513 Nonpathogen - Endonuclease/exonuclease/phosphatase Krad_0544 1 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 152967724 Common - cell division ATP-binding protein FtsE Krad_3781 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 152967657 Common - malate--quinone oxidoreductase Krad_3714 58 COG0579 COG0579, Predicted dehydrogenase General function prediction only 152966841 Common - ABC transporter-related protein Krad_2897 249 COG1119 ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA Inorganic ion transport and metabolism 152965026 Nonpathogen - hypothetical protein Krad_1058 1 None None None 152966757 Common - monooxygenase FAD-binding Krad_2807 75 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 152964534 Common - hypothetical protein Krad_0565 17 COG4124 ManB, Beta-mannanase Carbohydrate transport and metabolism 152964119 Common - Gamma-glutamyltransferase Krad_0148 140 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 152964683 Common - ribosomal protein S11 Krad_0714 247 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 152964162 Nonpathogen - Camphor resistance CrcB protein Krad_0191 1 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 152964288 Nonpathogen - hypothetical protein Krad_0318 3 None None None 152966422 Common - short-chain dehydrogenase/reductase SDR Krad_2466 173 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152966173 Common - hypothetical protein Krad_2212 11 None None None 152964508 Common - GTP cyclohydrolase I Krad_0539 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 152966624 Nonpathogen - hypothetical protein Krad_2672 1 None None None 152968421 Common - delta-1-pyrroline-5-carboxylate dehydrogenase Krad_4482 218 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 152964258 Common - cobalamin synthesis CobW domain protein Krad_0288 52 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 152965693 Nonpathogen - hypothetical protein Krad_1727 2 None None None 152965499 Common - RNA polymerase, sigma 70 subunit, RpoD family Krad_1531 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 152967911 Common - Phosphoesterase HXTX Krad_3968 9 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 152967078 Common - type II secretion system protein E Krad_3134 178 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 152966793 Common - transposase IS3/IS911 family protein Krad_2846 21 None None None 152967387 Nonpathogen - diguanylate cyclase Krad_3444 1 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152968415 Nonpathogen - hypothetical protein Krad_4476 2 None None None 152964552 Common - Mannitol dehydrogenase domain Krad_0583 86 COG0246 MtlD, Mannitol-1-phosphate/altronate dehydrogenases Carbohydrate transport and metabolism 152966584 Nonpathogen - hypothetical protein Krad_2632 1 None None None 152965070 Common - oxidoreductase domain protein Krad_1102 15 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152965654 Nonpathogen - hypothetical protein Krad_1688 1 None None None 152966804 Common - helix-turn-helix- domain containing protein AraC type Krad_2858 116 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 152966661 Common - aldo/keto reductase Krad_2709 156 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 152965264 Common - trehalose synthase Krad_1296 172 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 152967246 Common - alpha/beta hydrolase fold Krad_3302 12 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152967580 Common - putative cold-shock DNA-binding domain protein Krad_3637 185 COG1278 CspC, Cold shock proteins Transcription 152965560 Nonpathogen - hypothetical protein Krad_1594 1 None None None 152964768 Common - exopolyphosphatase-related protein Krad_0800 11 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 152963981 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Krad_0009 10 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 152965488 Common - PfkB domain protein Krad_1520 62 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 152966454 Common - Histidinol dehydrogenase Krad_2498 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 152965449 Common - hypothetical protein Krad_1481 10 COG3503 COG3503, Predicted membrane protein Function unknown 152967194 Common - cytochrome c oxidase subunit III Krad_3250 158 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 152967403 Common - binding-protein-dependent transport systems inner membrane component Krad_3460 133 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 152964691 Common - phosphoglucosamine mutase Krad_0722 238 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 152965671 Nonpathogen - hypothetical protein Krad_1705 1 None None None 152965044 Common - Ppx/GppA phosphatase Krad_1076 167 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 152967827 Nonpathogen - hypothetical protein Krad_3884 2 None None None 152964763 Nonpathogen - hypothetical protein Krad_0795 1 None None None 152964797 Common - ATP-dependent DNA helicase, RecQ family Krad_0829 234 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 152967847 Common - phosphoribosylaminoimidazole carboxylase, catalytic subunit Krad_3904 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 152966380 Common - Activator of Hsp90 ATPase 1 family protein Krad_2420 6 COG3832 COG3832, Uncharacterized conserved protein Function unknown 152967501 Common - L-aspartate oxidase Krad_3558 225 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 152966028 Common - adenosine deaminase Krad_2063 96 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 152966096 Common - PfkB domain protein Krad_2132 137 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 152965039 Common - ROK family protein Krad_1071 96 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 152967595 Common - ABC transporter-related protein Krad_3652 249 COG1135 AbcC, ABC-type metal ion transport system, ATPase component Inorganic ion transport and metabolism 152964392 Common - endonuclease III Krad_0422 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 152965486 Nonpathogen - hypothetical protein Krad_1518 1 None None None 152968207 Common - transcriptional regulator, LysR family Krad_4264 181 COG0583 LysR, Transcriptional regulator Transcription 152964904 Common - Methylenetetrahydrofolate reductase (NAD(P)H) Krad_0936 137 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 152966329 Nonpathogen - hypothetical protein Krad_2369 1 None None None 152964745 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Krad_0777 7 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152965103 Common - AAA ATPase central domain protein Krad_1135 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 152968441 Nonpathogen - hypothetical protein Krad_4502 1 None None None 152965773 Common - integral membrane sensor signal transduction histidine kinase Krad_1807 214 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152966544 Common - Methyltransferase type 11 Krad_2590 51 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 152966066 Common - hypothetical protein Krad_2101 20 COG4850 COG4850, Uncharacterized conserved protein Function unknown 152964148 Nonpathogen - hypothetical protein Krad_0177 1 None None None 152966950 Common - Uracil phosphoribosyltransferase Krad_3006 109 COG2065 PyrR, Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase Nucleotide transport and metabolism 152964883 Common - hypothetical protein Krad_0915 14 None None None 152964989 Common - glycerol kinase Krad_1021 179 COG0554 GlpK, Glycerol kinase Energy production and conversion 152968141 Common - exodeoxyribonuclease III Xth Krad_4198 196 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 152964443 Common - hypothetical protein Krad_0473 15 COG3428 COG3428, Predicted membrane protein Function unknown 152966989 Common - beta-lactamase domain protein Krad_3045 211 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 152963990 Nonpathogen - O-antigen polymerase Krad_0018 2 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 152966815 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Krad_2869 42 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 152966875 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Krad_2931 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 152965079 Common - sodium/hydrogen exchanger Krad_1111 63 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 152965184 Nonpathogen - ribonuclease BN Krad_1216 2 COG1295 Rbn, Predicted membrane protein Function unknown 152964063 Common - YceI family protein Krad_0092 117 COG2353 COG2353, Uncharacterized conserved protein Function unknown 152968053 Common - putative transcriptional regulator, AsnC family Krad_4110 148 COG1522 Lrp, Transcriptional regulators Transcription 152965447 Common - dihydrodipicolinate synthase Krad_1479 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 152967214 Common - oxidoreductase domain protein Krad_3270 77 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152965152 Nonpathogen - hypothetical protein Krad_1184 6 None None None 152964251 Nonpathogen - hypothetical protein Krad_0281 1 None None None 152966158 Common - diacylglycerol kinase catalytic region Krad_2195 22 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 152966340 Nonpathogen - hypothetical protein Krad_2380 3 None None None 152964121 Common - transcriptional regulator, GntR family Krad_0150 135 COG1802 GntR, Transcriptional regulators Transcription 152965435 Common - peptidase M16 domain protein Krad_1467 201 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 152964971 Common - protein serine phosphatase with GAF(s) sensor(s) Krad_1003 132 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152966326 Nonpathogen - hypothetical protein Krad_2366 1 None None None 152967737 Nonpathogen - integral membrane protein Krad_3794 1 None None None 152964985 Common - K+-transporting ATPase, B subunit Krad_1017 232 COG2216 KdpB, High-affinity K+ transport system, ATPase chain B Inorganic ion transport and metabolism 152965807 Common - protein of unknown function DUF805 Krad_1841 55 COG3152 COG3152, Predicted membrane protein Function unknown 152964267 Common - extracellular solute-binding protein family 1 Krad_0297 93 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152965295 Common - Rieske (2Fe-2S) domain protein Krad_1327 80 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 152967341 Common - GCN5-related N-acetyltransferase Krad_3397 64 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 152965010 Common - methionyl-tRNA synthetase Krad_1042 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152966957 Common - 3-dehydroquinate synthase Krad_3013 205 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 152966304 Nonpathogen - hypothetical protein Krad_2344 1 None None None 152967088 Common - hypothetical protein Krad_3144 6 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 152965433 Common - ribosomal protein S15 Krad_1465 214 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 152965945 Nonpathogen - integral membrane protein Krad_1979 1 None None None 152967924 Common - Glycine hydroxymethyltransferase Krad_3981 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 152968061 Common - GCN5-related N-acetyltransferase Krad_4118 53 COG2153 ElaA, Predicted acyltransferase General function prediction only 152966916 Common - hypothetical protein Krad_2972 14 COG4552 Eis, Predicted acetyltransferase involved in intracellular survival and related acetyltransferases General function prediction only 152964965 Nonpathogen - hypothetical protein Krad_0997 1 None None None 152964505 Common - hypothetical protein Krad_0536 23 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 152967723 Common - protein of unknown function DUF214 Krad_3780 59 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 152966888 Common - Monosaccharide-transporting ATPase Krad_2944 109 COG4214 XylH, ABC-type xylose transport system, permease component Carbohydrate transport and metabolism 152967104 Common - arginine biosynthesis bifunctional protein ArgJ Krad_3160 167 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 152966867 Common - transaldolase Krad_2923 117 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 152967545 Common - diguanylate cyclase Krad_3602 17 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152965515 Common - hypothetical protein Krad_1549 8 None None None 152963985 Common - Undecaprenyl-phosphate galactose phosphotransferase Krad_0013 183 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 152964598 Common - cytochrome c biogenesis protein transmembrane region Krad_0629 79 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 152965951 Nonpathogen - Haem oxygenase Krad_1985 1 COG3230 HemO, Heme oxygenase Inorganic ion transport and metabolism 152967524 Common - hypothetical protein Krad_3581 18 None None None 152966431 Common - SNARE associated Golgi protein Krad_2475 102 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 152965052 Common - ABC transporter-related protein Krad_1084 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 152965962 Common - transcriptional regulator, XRE family Krad_1997 41 COG1396 HipB, Predicted transcriptional regulators Transcription 152966831 Common - peptidase S1 and S6 chymotrypsin/Hap Krad_2886 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 152964137 Common - Rhodanese domain protein Krad_0166 158 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152967414 Common - glycoside hydrolase clan GH-D Krad_3471 41 COG3345 GalA, Alpha-galactosidase Carbohydrate transport and metabolism 152968221 Common - drug resistance transporter, EmrB/QacA subfamily Krad_4278 169 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152964243 Common - hypothetical protein Krad_0273 24 COG4913 COG4913, Uncharacterized protein conserved in bacteria Function unknown 152967402 Common - extracellular solute-binding protein family 1 Krad_3459 94 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152967004 Common - pyridoxine biosynthesis protein Krad_3060 87 COG0214 SNZ1, Pyridoxine biosynthesis enzyme Coenzyme metabolism 152966971 Common - twitching motility protein Krad_3027 208 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 152965300 Common - regulatory protein LacI Krad_1332 126 COG1609 PurR, Transcriptional regulators Transcription 152967395 Common - gamma-glutamyl phosphate reductase Krad_3452 191 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 152965979 Common - dihydrodipicolinate synthetase Krad_2014 69 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 152967602 Common - SSS sodium solute transporter superfamily Krad_3659 140 COG4147 DhlC, Predicted symporter General function prediction only 152964185 Common - Methyltransferase type 11 Krad_0214 35 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152967984 Common - amidophosphoribosyltransferase Krad_4041 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 152968233 Common - transcriptional regulator, XRE family Krad_4290 72 COG1476 COG1476, Predicted transcriptional regulators Transcription 152966285 Common - transcriptional regulator, TetR family Krad_2324 5 COG1309 AcrR, Transcriptional regulator Transcription 152964170 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Krad_0199 225 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 152967808 Common - glycosyl transferase group 1 Krad_3865 26 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152964453 Common - anti-sigma-factor antagonist Krad_0483 52 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 152964223 Common - hypothetical protein Krad_0253 9 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 152964956 Common - phosphoribulokinase/uridine kinase Krad_0988 35 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 152964596 Common - Phosphoglycerate mutase Krad_0627 32 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 152968286 Common - GCN5-related N-acetyltransferase Krad_4343 5 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 152964976 Common - glycerol kinase Krad_1008 179 COG0554 GlpK, Glycerol kinase Energy production and conversion 152967612 Common - transferase hexapeptide repeat containing protein Krad_3669 212 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 152964669 Common - ribosomal protein L5 Krad_0700 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 152963977 Common - protein of unknown function DUF721 Krad_0005 19 COG5512 COG5512, Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives General function prediction only 152967238 Common - luciferase family protein Krad_3294 99 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 152964639 Common - adenosine deaminase Krad_0670 96 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 152964641 Common - ABC transporter-related protein Krad_0672 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 152964391 Common - NUDIX hydrolase Krad_0421 48 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 152965339 Common - putative methyltransferase Krad_1371 65 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 152965059 Common - peptide methionine sulfoxide reductase Krad_1091 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 152967471 Common - transcriptional regulator, winged helix family Krad_3528 28 COG3903 COG3903, Predicted ATPase General function prediction only 152968293 Common - Alpha/beta hydrolase fold-3 domain protein Krad_4350 113 COG0657 Aes, Esterase/lipase Lipid metabolism 152964876 Common - cation diffusion facilitator family transporter Krad_0908 47 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 152965841 Common - protein of unknown function DUF245 domain protein Krad_1875 16 None None None 152968393 Common - Transcriptional regulator IclR Krad_4454 116 COG1414 IclR, Transcriptional regulator Transcription 152965093 Common - 4-phytase Krad_1125 176 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 152966166 Common - transcriptional regulator, TetR family Krad_2205 26 COG1309 AcrR, Transcriptional regulator Transcription 152964479 Common - diguanylate cyclase/phosphodiesterase Krad_0510 178 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152966635 Nonpathogen - hypothetical protein Krad_2683 1 None None None 152966856 Common - ABC transporter-related protein Krad_2912 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 152968118 Common - ABC transporter-related protein Krad_4175 245 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 152966225 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Krad_2264 32 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152967746 Common - putative transcriptional regulator Krad_3803 7 None None None 152967150 Nonpathogen - hypothetical protein Krad_3206 2 None None None 152967366 Common - DNA polymerase III, delta subunit Krad_3422 19 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 152968189 Common - H(+)-transporting two-sector ATPase Krad_4246 85 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 152968165 Nonpathogen - hypothetical protein Krad_4222 1 None None None 152965814 Nonpathogen - PBS lyase heat-like repeat Krad_1848 2 None None None 152964702 Common - ribosomal-protein-alanine acetyltransferase Krad_0733 11 COG0456 RimI, Acetyltransferases General function prediction only 152965440 Common - Kojibiose phosphorylase Krad_1472 50 COG1554 ATH1, Trehalose and maltose hydrolases (possible phosphorylases) Carbohydrate transport and metabolism 152967665 Common - Xylose isomerase domain protein TIM barrel Krad_3722 32 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 152964203 Nonpathogen - putative anti-sigma regulatory factor, serine/threonine protein kinase Krad_0233 5 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 152967408 Common - helix-turn-helix- domain containing protein AraC type Krad_3465 48 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 152967866 Common - daunorubicin resistance ABC transporter ATPase subunit Krad_3923 248 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 152967451 Common - tRNA synthetase valyl/leucyl anticodon-binding Krad_3508 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis