Methanococcus aeolicus Nankai-3, complete genome NC_009635 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 150400750 Common - fructose-bisphosphate aldolase Maeo_0316 97 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 150401746 Common - porphobilinogen deaminase Maeo_1324 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 150401551 Nonpathogen rpl34e 50S ribosomal protein L34e Maeo_1128 16 COG2174 RPL34A, Ribosomal protein L34E Translation, ribosomal structure and biogenesis 150401094 Common - filamentation induced by cAMP protein Fic Maeo_0664 33 COG3177 COG3177, Uncharacterized conserved protein Function unknown 150400957 Nonpathogen - hypothetical protein Maeo_0525 1 None None None 150401651 Nonpathogen - hypothetical protein Maeo_1229 1 None None None 150401039 Common - ribonuclease HII Maeo_0608 59 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 150400798 Nonpathogen - hypothetical protein Maeo_0365 1 None None None 150400966 Nonpathogen - hypothetical protein Maeo_0534 1 None None None 150401811 Common rps3p 30S ribosomal protein S3P Maeo_1389 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 150401014 Common - ATP-dependent protease La Maeo_0583 29 COG4930 COG4930, Predicted ATP-dependent Lon-type protease Posttranslational modification, protein turnover, chaperones 150401675 Common - putative ATP binding protein Maeo_1253 43 COG2102 COG2102, Predicted ATPases of PP-loop superfamily General function prediction only 150401277 Common - 2-isopropylmalate synthase Maeo_0849 225 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 150401664 Nonpathogen - hypothetical protein Maeo_1242 1 None None None 150400818 Common - NAD-dependent epimerase/dehydratase Maeo_0386 198 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 150401063 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0633 34 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 150401853 Common - nitrogenase component I, alpha chain Maeo_1431 54 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 150401457 Common - proteasome-activating nucleotidase Maeo_1033 249 COG1222 RPT1, ATP-dependent 26S proteasome regulatory subunit Posttranslational modification, protein turnover, chaperones 150401215 Common - transcription elongation factor NusA-like protein Maeo_0786 39 COG0195 NusA, Transcription elongation factor Transcription 150401638 Common - nickel-dependent hydrogenase large subunit Maeo_1215 99 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 150401200 Nonpathogen - protein of unknown function DUF129 Maeo_0771 9 COG4071 COG4071, Uncharacterized protein conserved in archaea Function unknown 150401750 Common - peptidylprolyl isomerase FKBP-type Maeo_1328 137 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 150400678 Common - TraB family protein Maeo_0242 39 COG1916 COG1916, Uncharacterized homolog of PrgY (pheromone shutdown protein) Function unknown 150401263 Common - deoxyribonuclease/rho motif-related TRAM Maeo_0835 29 COG3269 COG3269, Predicted RNA-binding protein, contains TRAM domain General function prediction only 150401699 Nonpathogen - hypothetical protein Maeo_1277 5 COG4010 COG4010, Uncharacterized protein conserved in archaea Function unknown 150401809 Nonpathogen - hypothetical protein Maeo_1387 1 None None None 150401492 Nonpathogen - hypothetical protein Maeo_1069 5 None None None 150400831 Common - histidinol-phosphate phosphatase family protein Maeo_0399 130 COG0241 HisB, Histidinol phosphatase and related phosphatases Amino acid transport and metabolism 150401723 Common - Glutamate synthase (NADPH) Maeo_1301 204 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 150401371 Nonpathogen - Protein of unknown function DUF356 Maeo_0946 11 COG1844 COG1844, Uncharacterized protein conserved in archaea Function unknown 150401423 Nonpathogen - ExsB family protein Maeo_0999 19 COG2117 COG2117, Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 150401043 Common - transferase hexapeptide repeat containing protein Maeo_0612 213 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 150400515 Nonpathogen - Protein of unknown function DUF473 Maeo_0077 11 COG1935 COG1935, Uncharacterized conserved protein Function unknown 150401913 Nonpathogen - hypothetical protein Maeo_1491 2 None None None 150400910 Common - thiamine pyrophosphate protein domain protein TPP-binding Maeo_0478 111 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 150400717 Nonpathogen - Protein of unknown function DUF359 Maeo_0282 29 COG1909 COG1909, Uncharacterized protein conserved in archaea Function unknown 150401460 Common - protein of unknown function DUF521 Maeo_1036 39 COG1679 COG1679, Uncharacterized conserved protein Function unknown 150401214 Common rps12P 30S ribosomal protein S12P Maeo_0785 168 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 150401692 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit D Maeo_1270 14 COG4060 MtrD, Tetrahydromethanopterin S-methyltransferase, subunit D Coenzyme metabolism 150400791 Nonpathogen - hypothetical protein Maeo_0358 8 COG4041 COG4041, Predicted membrane protein Function unknown 150400671 Common leuS leucyl-tRNA synthetase Maeo_0233 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150400696 Nonpathogen - Flagella accessory C family protein Maeo_0261 6 COG3352 FlaC, Putative archaeal flagellar protein C Cell motility and secretion 150400987 Common - amidohydrolase Maeo_0556 166 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 150401378 Common - Rubrerythrin Maeo_0954 20 COG1592 COG1592, Rubrerythrin Energy production and conversion 150401803 Common - sirohydrochlorin cobaltochelatase Maeo_1381 60 COG2138 COG2138, Uncharacterized conserved protein Function unknown 150400477 Common - transposase IS605 OrfB Maeo_0038 20 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 150400929 Nonpathogen - hypothetical protein Maeo_0497 2 None None None 150401385 Common - TatD-related deoxyribonuclease Maeo_0961 68 COG1099 COG1099, Predicted metal-dependent hydrolases with the TIM-barrel fold General function prediction only 150400595 Common - hypothetical protein Maeo_0157 64 COG1641 COG1641, Uncharacterized conserved protein Function unknown 150401406 Common radA DNA repair and recombination protein RadA Maeo_0982 66 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 150400705 Common - phosphate binding protein Maeo_0270 149 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 150401632 Common - homoserine dehydrogenase Maeo_1209 219 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 150401007 Common - peptidase U32 Maeo_0576 140 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 150401785 Nonpathogen - putative monovalent cation/H+ antiporter subunit E Maeo_1363 5 COG1863 MnhE, Multisubunit Na+/H+ antiporter, MnhE subunit Inorganic ion transport and metabolism 150401347 Common - AAA family ATPase, CDC48 subfamily Maeo_0920 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 150401899 Common - (NiFe) hydrogenase maturation protein HypF Maeo_1477 110 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 150400604 Nonpathogen - glucose-methanol-choline oxidoreductase Maeo_0166 8 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 150401835 Nonpathogen - hypothetical protein Maeo_1413 1 COG4023 SBH1, Preprotein translocase subunit Sec61beta Intracellular trafficking and secretion 150400808 Nonpathogen - CBS domain containing protein Maeo_0375 5 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 150401587 Common - 3-dehydroquinate synthase Maeo_1164 28 COG1465 COG1465, Predicted alternative 3-dehydroquinate synthase Amino acid transport and metabolism 150401524 Common rps13p 30S ribosomal protein S13P Maeo_1101 214 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 150401155 Common - hypothetical protein Maeo_0726 20 COG1751 COG1751, Uncharacterized conserved protein Function unknown 150401138 Common - Cellulase Maeo_0709 92 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 150401363 Common - NADH ubiquinone oxidoreductase 20 kDa subunit Maeo_0938 192 COG3260 COG3260, Ni,Fe-hydrogenase III small subunit Energy production and conversion 150401597 Common - acetyl-CoA decarbonylase/synthase complex subunit alpha Maeo_1174 16 COG1152 CdhA, CO dehydrogenase/acetyl-CoA synthase alpha subunit Energy production and conversion 150401027 Common - histidine triad (HIT) protein Maeo_0596 240 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 150400780 Common - 3-isopropylmalate dehydratase, small subunit Maeo_0347 212 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 150401616 Nonpathogen - Protein of unknown function DUF54 Maeo_1193 25 COG1931 COG1931, Uncharacterized protein conserved in archaea Function unknown 150400862 Common - glycosyl transferase group 1 Maeo_0430 230 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 150401427 Common - protein of unknown function DUF116 Maeo_1003 31 COG1852 COG1852, Uncharacterized conserved protein Function unknown 150400545 Common - magnesium chelatase Maeo_0107 61 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 150400991 Common - ATP-NAD/AcoX kinase Maeo_0560 242 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 150401875 Nonpathogen - hypothetical protein Maeo_1453 1 None None None 150400598 Nonpathogen - OsmC family protein Maeo_0160 3 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 150400874 Common - beta-lactamase domain protein Maeo_0442 23 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 150400973 Nonpathogen - hypothetical protein Maeo_0542 1 None None None 150400561 Common - protein of unknown function DUF105 Maeo_0123 11 COG1865 COG1865, Uncharacterized conserved protein Function unknown 150401918 Common - adenine phosphoribosyltransferase Maeo_1496 169 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 150400883 Common - TrkA-N domain protein Maeo_0451 203 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 150401149 Nonpathogen - putative translation factor pelota Maeo_0720 33 COG1537 PelA, Predicted RNA-binding proteins General function prediction only 150400765 Common - Desulfoferrodoxin ferrous iron-binding region Maeo_0331 31 COG2033 COG2033, Desulfoferrodoxin Energy production and conversion 150400920 Common - Cobyrinic acid ac-diamide synthase Maeo_0488 237 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 150401670 Common - formate dehydrogenase family accessory protein FdhD Maeo_1248 130 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 150400950 Common - Glutamate-1-semialdehyde 2,1-aminomutase Maeo_0518 91 COG0371 GldA, Glycerol dehydrogenase and related enzymes Energy production and conversion 150400660 Common - stationary-phase survival protein SurE Maeo_0222 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 150401192 Nonpathogen - phosphatidate cytidylyltransferase Maeo_0763 6 COG0170 SEC59, Dolichol kinase Lipid metabolism 150400683 Nonpathogen - shikimate kinase Maeo_0247 27 COG1685 COG1685, Archaeal shikimate kinase Amino acid transport and metabolism / Coenzyme metabolism 150401161 Nonpathogen - hypothetical protein Maeo_0732 2 COG1667 COG1667, Uncharacterized protein conserved in archaea Function unknown 150400951 Common - protein of unknown function DUF214 Maeo_0519 187 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 150401788 Common - cation diffusion facilitator family transporter Maeo_1366 214 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 150401185 Common - tRNA pseudouridine synthase D TruD Maeo_0756 79 COG0585 COG0585, Uncharacterized conserved protein Function unknown 150400720 Common radB DNA repair and recombination protein RadB Maeo_0285 159 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 150400728 Common - PHP domain protein Maeo_0293 49 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 150401101 Nonpathogen - RNAse P, Rpr2/Rpp21 subunit Maeo_0671 19 COG2023 RPR2, RNase P subunit RPR2 Translation, ribosomal structure and biogenesis 150401261 Common - homoserine kinase Maeo_0833 121 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 150401283 Common - SirA family protein Maeo_0855 42 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 150400618 Nonpathogen - Shwachman-Bodian-Diamond syndrome protein Maeo_0180 34 COG1500 COG1500, Predicted exosome subunit Translation, ribosomal structure and biogenesis 150400738 Common - putative signal transduction protein with CBS domains Maeo_0304 7 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 150401177 Nonpathogen - hypothetical protein Maeo_0748 1 None None None 150401222 Common - protein of unknown function DUF39 Maeo_0793 113 COG1900 COG1900, Uncharacterized conserved protein Function unknown 150400911 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Maeo_0479 133 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 150400740 Common - NADH dehydrogenase (quinone) Maeo_0306 196 COG3261 HycE, Ni,Fe-hydrogenase III large subunit Energy production and conversion 150400767 Common - extracellular solute-binding protein family 1 Maeo_0333 129 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 150400902 Nonpathogen - hypothetical protein Maeo_0470 1 COG1229 FwdA, Formylmethanofuran dehydrogenase subunit A Energy production and conversion 150401584 Nonpathogen - hypothetical protein Maeo_1161 1 None None None 150400810 Common - UTP-glucose-1-phosphate uridylyltransferase Maeo_0377 234 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 150400942 Common - binding-protein-dependent transport systems inner membrane component Maeo_0510 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150401321 Common - AIR synthase related protein Maeo_0894 50 COG1973 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 150401581 Nonpathogen - Protein of unknown function UPF0113 Maeo_1158 7 COG1374 NIP7, Protein involved in ribosomal biogenesis, contains PUA domain Translation, ribosomal structure and biogenesis 150400760 Common - peroxiredoxin Maeo_0326 215 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 150401563 Common - AAA ATPase central domain protein Maeo_1140 249 COG1223 COG1223, Predicted ATPase (AAA+ superfamily) General function prediction only 150401814 Nonpathogen - ribonuclease P protein component 1 Maeo_1392 26 COG1588 POP4, RNase P/RNase MRP subunit p29 Translation, ribosomal structure and biogenesis 150401343 Common - delta-aminolevulinic acid dehydratase Maeo_0916 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 150400648 Common - acetyl-CoA decarbonylase/synthase complex subunit delta Maeo_0210 20 COG2069 CdhD, CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein) Energy production and conversion 150400507 Nonpathogen - hypothetical protein Maeo_0069 8 COG2083 COG2083, Uncharacterized protein conserved in archaea Function unknown 150401763 Nonpathogen - hypothetical protein Maeo_1341 1 None None None 150400602 Common - CBS domain containing protein Maeo_0164 183 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 150400529 Common - DEAD/DEAH box helicase domain protein Maeo_0091 130 COG1204 COG1204, Superfamily II helicase General function prediction only 150401140 Common - SMC domain protein Maeo_0711 128 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 150401921 Common - Ion transport 2 domain protein Maeo_1499 71 None None None 150401548 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Maeo_1125 25 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 150400949 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0517 46 COG2768 COG2768, Uncharacterized Fe-S center protein General function prediction only 150400558 Common - Cobaltochelatase Maeo_0120 89 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 150400457 Nonpathogen - hypothetical protein Maeo_0018 7 COG1630 COG1630, Uncharacterized protein conserved in archaea Function unknown 150401404 Common - alpha-glucan phosphorylase Maeo_0980 79 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 150401485 Nonpathogen - regulatory protein ArsR Maeo_1061 11 COG3398 COG3398, Uncharacterized protein conserved in archaea Function unknown 150401828 Common rpl15p 50S ribosomal protein L15P Maeo_1406 37 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 150401513 Common - hydrogenase assembly chaperone hypC/hupF Maeo_1090 88 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 150401706 Common - pyruvate ferredoxin oxidoreductase subunit beta Maeo_1284 128 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 150401089 Nonpathogen - Transcription factor CBF/NF-Y histone Maeo_0659 20 COG2036 HHT1, Histones H3 and H4 Chromatin structure and dynamics 150401335 Common - dihydrodipicolinate synthase Maeo_0908 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 150401514 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_1091 37 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 150400486 Common - signal recognition particle-docking protein FtsY Maeo_0048 246 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 150400465 Common - DNA topoisomerase I Maeo_0026 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 150401446 Common - chromosome segregation and condensation protein ScpA Maeo_1022 9 COG1354 COG1354, Uncharacterized conserved protein Function unknown 150400933 Common - DsrE family protein Maeo_0501 16 COG2044 COG2044, Predicted peroxiredoxins General function prediction only 150401685 Nonpathogen - hypothetical protein Maeo_1263 1 None None None 150400983 Common - cell division ATPase MinD Maeo_0552 226 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 150400867 Nonpathogen - diphthine synthase Maeo_0435 34 COG1798 DPH5, Diphthamide biosynthesis methyltransferase Translation, ribosomal structure and biogenesis 150401299 Common - small GTP-binding protein Maeo_0871 246 COG1163 DRG, Predicted GTPase General function prediction only 150401502 Common - CRISPR-associated RAMP protein, Csm5 family Maeo_1079 12 COG1332 COG1332, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 150400635 Common - TatD-related deoxyribonuclease Maeo_0197 43 COG1099 COG1099, Predicted metal-dependent hydrolases with the TIM-barrel fold General function prediction only 150401462 Common - glucosamine--fructose-6-phosphate aminotransferase, isomerizing Maeo_1038 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 150400442 Common - magnesium and cobalt transport protein CorA Maeo_0003 176 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 150401350 Nonpathogen - riboflavin synthase Maeo_0923 22 COG1731 COG1731, Archaeal riboflavin synthase Coenzyme metabolism 150401113 Common ilvH acetolactate synthase 3 regulatory subunit Maeo_0683 194 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 150401845 Common - hypothetical protein Maeo_1423 10 COG2014 COG2014, Uncharacterized conserved protein Function unknown 150401438 Nonpathogen - tRNA-splicing endonuclease subunit alpha Maeo_1014 32 COG1676 SEN2, tRNA splicing endonuclease Translation, ribosomal structure and biogenesis 150400828 Common - glycosyl transferase family 2 Maeo_0396 180 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 150400520 Nonpathogen - formylmethanofuran dehydrogenase subunit E region Maeo_0082 21 COG2191 COG2191, Formylmethanofuran dehydrogenase subunit E Energy production and conversion 150401032 Common - ferredoxin Maeo_0601 42 COG3894 COG3894, Uncharacterized metal-binding protein General function prediction only 150401255 Common - uncharacterized membrane protein Maeo_0826 11 None None None 150401880 Common - RNA 3'-terminal-phosphate cyclase Maeo_1458 47 COG0430 RCL1, RNA 3'-terminal phosphate cyclase RNA processing and modification 150401234 Common rplW 50S ribosomal protein L23 Maeo_0805 176 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 150401383 Common - arsenical-resistance protein Maeo_0959 129 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 150401239 Common - phosphoribosylaminoimidazole synthetase Maeo_0810 232 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 150401671 Nonpathogen - hypothetical protein Maeo_1249 5 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 150400892 Common - Phosphomethylpyrimidine kinase Maeo_0460 218 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 150400731 Common - heavy metal translocating P-type ATPase Maeo_0297 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 150400838 Nonpathogen - hypothetical protein Maeo_0406 1 None None None 150400533 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0095 43 COG1148 HdrA, Heterodisulfide reductase, subunit A and related polyferredoxins Energy production and conversion 150400842 Nonpathogen - hypothetical protein Maeo_0410 3 None None None 150401538 Common trpC indole-3-glycerol-phosphate synthase Maeo_1115 219 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 150401837 Common - hypothetical protein Maeo_1415 22 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 150401927 Common - Transketolase central region Maeo_1505 230 COG3958 COG3958, Transketolase, C-terminal subunit Carbohydrate transport and metabolism 150401575 Nonpathogen - type II secretion system protein Maeo_1152 10 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 150401246 Nonpathogen - putative TIM-barrel protein Maeo_0817 13 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 150401553 Nonpathogen - adenylate kinase Maeo_1130 23 COG2019 AdkA, Archaeal adenylate kinase Nucleotide transport and metabolism 150401777 Nonpathogen - putative monovalent cation/H+ antiporter subunit B Maeo_1355 9 COG2111 MnhB, Multisubunit Na+/H+ antiporter, MnhB subunit Inorganic ion transport and metabolism 150400711 Nonpathogen - hypothetical protein Maeo_0276 6 COG1710 COG1710, Uncharacterized protein conserved in archaea Function unknown 150400554 Nonpathogen - hypothetical protein Maeo_0116 1 None None None 150400858 Common - transferase hexapeptide repeat containing protein Maeo_0426 152 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 150401139 Nonpathogen - Nucleotide binding protein PINc Maeo_0710 15 COG1412 COG1412, Uncharacterized proteins of PilT N-term./Vapc superfamily General function prediction only 150401628 Nonpathogen - hypothetical protein Maeo_1205 2 None None None 150401209 Common - protein of unknown function DUF169 Maeo_0780 27 COG2043 COG2043, Uncharacterized protein conserved in archaea Function unknown 150401317 Nonpathogen - hypothetical protein Maeo_0890 2 None None None 150401253 Nonpathogen - protein of unknown function DUF112 transmembrane Maeo_0824 22 COG1784 COG1784, Predicted membrane protein Function unknown 150401791 Common - aspartate-semialdehyde dehydrogenase Maeo_1369 213 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 150401566 Common - cobyrinic acid a,c-diamide synthase Maeo_1143 20 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 150401666 Nonpathogen - hypothetical protein Maeo_1244 1 None None None 150401851 Nonpathogen - hypothetical protein Maeo_1429 1 None None None 150401124 Common - Roadblock/LC7 family protein Maeo_0695 26 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 150400479 Common - phospholipase D/Transphosphatidylase Maeo_0041 39 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 150400652 Common - NUDIX hydrolase Maeo_0214 155 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 150400834 Common - phosphoheptose isomerase Maeo_0402 124 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 150401824 Nonpathogen rpl19e 50S ribosomal protein L19e Maeo_1402 34 COG2147 RPL19A, Ribosomal protein L19E Translation, ribosomal structure and biogenesis 150400881 Common - molybdopterin biosynthesis MoaE protein Maeo_0449 27 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 150401425 Common - hypothetical protein Maeo_1001 20 None None None 150401592 Common - L-seryl-tRNA selenium transferase Maeo_1169 15 COG1921 SelA, Selenocysteine synthase [seryl-tRNASer selenium transferase] Amino acid transport and metabolism 150401082 Common - 3-isopropylmalate dehydratase, small subunit Maeo_0652 221 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 150401244 Common - DEAD/DEAH box helicase domain protein Maeo_0815 193 COG1202 COG1202, Superfamily II helicase, archaea-specific General function prediction only 150401079 Nonpathogen - S-layer protein Maeo_0649 4 None None None 150401589 Nonpathogen - DNA polymerase II small subunit Maeo_1166 24 COG1311 HYS2, Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B DNA replication, recombination, and repair 150400718 Nonpathogen rps24e 30S ribosomal protein S24e Maeo_0283 22 COG2004 RPS24A, Ribosomal protein S24E Translation, ribosomal structure and biogenesis 150400903 Common - ABC transporter related Maeo_0471 249 COG1135 AbcC, ABC-type metal ion transport system, ATPase component Inorganic ion transport and metabolism 150401421 Nonpathogen - 30S ribosomal protein S19e Maeo_0997 34 COG2238 RPS19A, Ribosomal protein S19E (S16A) Translation, ribosomal structure and biogenesis 150400643 Common - asparagine synthase (glutamine-hydrolyzing) Maeo_0205 192 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 150401408 Common - aminotransferase Maeo_0984 234 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 150400592 Common - ABC transporter related Maeo_0154 247 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 150401005 Common - Radical SAM domain protein Maeo_0574 168 COG1964 COG1964, Predicted Fe-S oxidoreductases General function prediction only 150401202 Nonpathogen - IMP cyclohydrolase Maeo_0773 13 COG3363 COG3363, Archaeal IMP cyclohydrolase Nucleotide transport and metabolism 150401056 Common - peptidase M48 Ste24p Maeo_0626 193 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 150401677 Nonpathogen - Protein of unknown function UPF0058 Maeo_1255 12 COG1745 COG1745, Predicted metal-binding protein General function prediction only 150401877 Common - thiamine-monophosphate kinase Maeo_1455 188 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 150401787 Common - DEAD/DEAH box helicase domain protein Maeo_1365 237 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 150401332 Nonpathogen - diphthamide biosynthesis protein Maeo_0905 30 COG1736 DPH2, Diphthamide synthase subunit DPH2 Translation, ribosomal structure and biogenesis 150401033 Common - spermidine synthase Maeo_0602 124 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 150401752 Nonpathogen - phosphopantetheine adenylyltransferase Maeo_1330 31 COG1019 COG1019, Predicted nucleotidyltransferase General function prediction only 150401279 Nonpathogen - hypothetical protein Maeo_0851 3 COG5306 COG5306, Uncharacterized conserved protein Function unknown 150401608 Common - beta-lactamase domain protein Maeo_1185 158 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 150400668 Common - UvrD/REP helicase Maeo_0230 228 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 150401359 Common - metal dependent phosphohydrolase Maeo_0933 43 COG3481 COG3481, Predicted HD-superfamily hydrolase General function prediction only 150401436 Common - cell division protein FtsZ Maeo_1012 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 150400708 Nonpathogen - hypothetical protein Maeo_0273 18 COG1885 COG1885, Uncharacterized protein conserved in archaea Function unknown 150401061 Common - putative signal-transduction protein with CBS domains Maeo_0631 177 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 150401459 Nonpathogen - hypothetical protein Maeo_1035 1 None None None 150401653 Nonpathogen - hypothetical protein Maeo_1231 1 None None None 150401339 Common - dihydroorotate dehydrogenase 1B Maeo_0912 239 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 150401801 Common - alpha-L-glutamate ligase, RimK family Maeo_1379 100 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 150400539 Nonpathogen - molydopterin dinucleotide-binding region Maeo_0101 17 COG1153 FwdD, Formylmethanofuran dehydrogenase subunit D Energy production and conversion 150400588 Common - glutamine synthetase, type I Maeo_0150 231 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 150400856 Common - Methyltransferase type 11 Maeo_0424 51 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 150401536 Common - hypothetical protein Maeo_1113 12 COG3815 COG3815, Predicted membrane protein Function unknown 150400763 Nonpathogen - glutaredoxin Maeo_0329 12 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 150401611 Common - MiaB-like tRNA modifying enzyme Maeo_1188 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 150401618 Common - branched-chain amino acid aminotransferase Maeo_1195 217 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 150401731 Common - protein of unknown function DUF84 Maeo_1309 38 COG1986 COG1986, Uncharacterized conserved protein Function unknown 150401687 Nonpathogen - Methyl-coenzyme M reductase, protein D Maeo_1265 14 COG4055 McrD, Methyl coenzyme M reductase, subunit D Coenzyme metabolism 150400532 Common - NADPH-dependent FMN reductase Maeo_0094 39 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 150401890 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Maeo_1468 125 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 150400633 Common - MscS Mechanosensitive ion channel Maeo_0195 193 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 150400744 Common - protein of unknown function DUF147 Maeo_0310 27 COG1624 COG1624, Uncharacterized conserved protein Function unknown 150400484 Common - Radical SAM domain protein Maeo_0046 33 COG1244 COG1244, Predicted Fe-S oxidoreductase General function prediction only 150400510 Common - protein of unknown function DUF92 transmembrane Maeo_0072 48 COG1836 COG1836, Predicted membrane protein Function unknown 150400726 Nonpathogen rpl37e 50S ribosomal protein L37e Maeo_0291 29 COG2126 RPL37A, Ribosomal protein L37E Translation, ribosomal structure and biogenesis 150401187 Nonpathogen - hypothetical protein Maeo_0758 21 COG1326 COG1326, Uncharacterized archaeal Zn-finger protein General function prediction only 150400662 Common - tetrahydromethanopterin formyltransferase Maeo_0224 24 COG2037 Ftr, Formylmethanofuran:tetrahydromethanopterin formyltransferase Energy production and conversion 150401096 Nonpathogen - hypothetical protein Maeo_0666 25 COG2042 COG2042, Uncharacterized conserved protein Function unknown 150400955 Nonpathogen - hypothetical protein Maeo_0523 10 COG2881 COG2881, Uncharacterized protein conserved in archaea Function unknown 150400879 Nonpathogen - hypothetical protein Maeo_0447 1 None None None 150401667 Nonpathogen - hypothetical protein Maeo_1245 1 None None None 150401642 Nonpathogen - hypothetical protein Maeo_1220 2 None None None 150401741 Common - PHP domain protein Maeo_1319 34 COG1379 COG1379, Uncharacterized conserved protein Function unknown 150401220 Common - DNA-directed RNA polymerase subunit beta'' Maeo_0791 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 150400989 Common purT phosphoribosylglycinamide formyltransferase 2 Maeo_0558 219 COG0027 PurT, Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) Nucleotide transport and metabolism 150401416 Common - binding-protein-dependent transport systems inner membrane component Maeo_0992 203 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 150400922 Common - MCM family protein Maeo_0490 47 COG1241 MCM2, Predicted ATPase involved in replication control, Cdc46/Mcm family DNA replication, recombination, and repair 150401710 Common - cell division protein FtsZ Maeo_1288 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 150401168 Common - hypothetical protein Maeo_0739 114 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 150400801 Nonpathogen - hypothetical protein Maeo_0368 5 COG4035 COG4035, Predicted membrane protein Function unknown 150400872 Nonpathogen - hypothetical protein Maeo_0440 4 None None None 150401634 Common - hypothetical protein Maeo_1211 37 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 150401349 Common - protein of unknown function DUF1643 Maeo_0922 12 COG4333 COG4333, Uncharacterized protein conserved in bacteria Function unknown 150400593 Common - cobalamin synthesis protein P47K Maeo_0155 66 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 150401431 Common gatA aspartyl/glutamyl-tRNA amidotransferase subunit A Maeo_1007 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 150401738 Common - pyridoxine biosynthesis protein Maeo_1316 87 COG0214 SNZ1, Pyridoxine biosynthesis enzyme Coenzyme metabolism 150401558 Nonpathogen - hypothetical protein Maeo_1135 1 None None None 150401599 Nonpathogen - protein of unknown function DUF81 Maeo_1176 2 COG0730 COG0730, Predicted permeases General function prediction only 150401522 Common rps11p 30S ribosomal protein S11P Maeo_1099 224 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 150400461 Nonpathogen - hypothetical protein Maeo_0022 2 COG1532 COG1532, Predicted RNA-binding protein General function prediction only 150401916 Common - aspartate aminotransferase Maeo_1494 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 150400685 Nonpathogen - acylphosphatase Maeo_0249 2 COG1254 AcyP, Acylphosphatases Energy production and conversion 150400971 Nonpathogen - hypothetical protein Maeo_0540 2 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 150401623 Common - phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Maeo_1200 215 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 150400543 Common - Radical SAM domain protein Maeo_0105 96 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 150400524 Common - molybdenum cofactor synthesis domain Maeo_0086 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 150400572 Common - protein of unknown function UPF0027 Maeo_0134 117 COG1690 RtcB, Uncharacterized conserved protein Function unknown 150401365 Common - NADH dehydrogenase (quinone) Maeo_0940 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 150400445 Common - glucose-6-phosphate isomerase Maeo_0006 211 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 150401546 Common - Dimethylmenaquinone methyltransferase Maeo_1123 74 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 150400677 Common - GCN5-related N-acetyltransferase Maeo_0241 19 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 150400993 Common - S-layer protein Maeo_0562 5 None None None 150400527 Nonpathogen - cobalt transport protein CbiN Maeo_0089 9 None None None 150401595 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_1172 174 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 150401174 Nonpathogen - hypothetical protein Maeo_0745 6 COG4068 COG4068, Uncharacterized protein containing a Zn-ribbon Function unknown 150401748 Nonpathogen - hypothetical protein Maeo_1326 1 None None None 150401345 Common - hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit Maeo_0918 148 COG1838 FumA, Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain Energy production and conversion 150400509 Common - RNA methyltransferase, TrmH family, group 1 Maeo_0071 155 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 150401337 Nonpathogen - chorismate mutase Maeo_0910 12 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 150401888 Common - pyruvate/ketoisovalerate oxidoreductase, gamma subunit Maeo_1466 74 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 150400500 Common - H+transporting two-sector ATPase E subunit Maeo_0062 17 COG1390 NtpE, Archaeal/vacuolar-type H+-ATPase subunit E Energy production and conversion 150401142 Nonpathogen - protein of unknown function DUF890 Maeo_0713 4 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 150401640 Common - hisA/hisF family protein Maeo_1218 36 COG1411 COG1411, Uncharacterized protein related to proFAR isomerase (HisA) General function prediction only 150401882 Common - molybdenum cofactor synthesis domain Maeo_1460 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 150400864 Nonpathogen - hypothetical protein Maeo_0432 2 None None None 150400600 Nonpathogen - protein of unknown function DUF99 Maeo_0162 32 COG1628 COG1628, Uncharacterized conserved protein Function unknown 150401499 Common - CRISPR-associated protein Cas4 Maeo_1076 8 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 150401826 Common rps5p 30S ribosomal protein S5P Maeo_1404 246 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 150401504 Common - CRISPR-associated RAMP protein, Csm3 family Maeo_1081 36 COG1337 COG1337, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 150400576 Common - AMMECR1 domain protein Maeo_0138 76 COG2078 AMMECR1, Uncharacterized conserved protein Function unknown 150401494 Common - CRISPR-associated protein Cas5, Hmari subtype Maeo_1071 16 None None None 150400967 Common - protein of unknown function DUF95 transmembrane Maeo_0535 19 COG1300 SpoIIM, Uncharacterized membrane protein Function unknown 150401004 Common - phosphate uptake regulator, PhoU Maeo_0573 200 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 150401833 Common - deoxycytidine triphosphate deaminase Maeo_1411 84 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 150401864 Common - Formylmethanofuran dehydrogenase Maeo_1442 76 COG2218 FwdC, Formylmethanofuran dehydrogenase subunit C Energy production and conversion 150401698 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit H Maeo_1276 17 COG1962 MtrH, Tetrahydromethanopterin S-methyltransferase, subunit H Coenzyme metabolism 150401122 Common - protein of unknown function DUF366 Maeo_0692 16 COG2029 COG2029, Uncharacterized conserved protein Function unknown 150401315 Nonpathogen - regulatory protein ArsR Maeo_0888 11 COG4189 COG4189, Predicted transcriptional regulator Transcription 150401453 Common - biotin--acetyl-CoA-carboxylase ligase Maeo_1029 85 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 150401478 Nonpathogen - protein of unknown function DUF98 Maeo_1054 12 COG3161 UbiC, 4-hydroxybenzoate synthetase (chorismate lyase) Coenzyme metabolism 150401467 Common - Coenzyme F420 hydrogenase Maeo_1043 77 COG1941 FrhG, Coenzyme F420-reducing hydrogenase, gamma subunit Energy production and conversion 150400694 Nonpathogen - flagellin protein Maeo_0259 9 COG1681 FlaB, Archaeal flagellins Cell motility and secretion 150401489 Nonpathogen - hypothetical protein Maeo_1065 3 None None None 150401708 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_1286 163 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 150401511 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Maeo_1088 208 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 150400845 Nonpathogen - Protein of unknown function DUF1616 Maeo_0413 11 COG4743 COG4743, Predicted membrane protein Function unknown 150401293 Common - putative transcriptional regulator, AsnC family Maeo_0865 162 COG1522 Lrp, Transcriptional regulators Transcription 150400812 Common - glucose-1-phosphate thymidylyltransferase Maeo_0379 234 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 150401482 Common - CDP-diacylglycerol--serine O-phosphatidyltransferase Maeo_1058 146 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 150400844 Nonpathogen - hypothetical protein Maeo_0412 1 None None None 150400940 Common - Nitrogenase Maeo_0508 66 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 150401305 Nonpathogen - DNA polymerase, beta-like region Maeo_0877 18 COG1665 COG1665, Uncharacterized protein conserved in archaea Function unknown 150401376 Common - protein of unknown function DUF795 Maeo_0951 18 COG1323 COG1323, Predicted nucleotidyltransferase General function prediction only 150401314 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0887 13 COG0348 NapH, Polyferredoxin Energy production and conversion 150401226 Common - PP-loop domain protein Maeo_0797 118 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 150400869 Nonpathogen - peptide chain release factor 1 Maeo_0437 35 COG1503 eRF1, Peptide chain release factor 1 (eRF1) Translation, ribosomal structure and biogenesis 150401903 Common - nitrogen regulatory protein P-II Maeo_1481 186 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 150401352 Nonpathogen - protein of unknown function DUF120 Maeo_0925 33 COG1339 COG1339, Transcriptional regulator of a riboflavin/FAD biosynthetic operon Transcription / Coenzyme metabolism 150401727 Nonpathogen - Transcription factor CBF/NF-Y histone Maeo_1305 20 COG2036 HHT1, Histones H3 and H4 Chromatin structure and dynamics 150401115 Nonpathogen - hypothetical protein Maeo_0685 2 None None None 150401908 Nonpathogen - domain of unknown function DUF1743 Maeo_1486 15 COG1571 COG1571, Predicted DNA-binding protein containing a Zn-ribbon domain General function prediction only 150401816 Common rpl14p 50S ribosomal protein L14P Maeo_1394 247 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 150400512 Nonpathogen - hypothetical protein Maeo_0074 2 None None None 150400826 Common - glycosyl transferase group 1 Maeo_0394 233 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 150401129 Nonpathogen - hypothetical protein Maeo_0700 2 None None None 150401097 Common - putative RNA methylase Maeo_0667 42 COG1041 COG1041, Predicted DNA modification methylase DNA replication, recombination, and repair 150400551 Common - transport system permease protein Maeo_0113 183 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 150401414 Common - phosphate uptake regulator, PhoU Maeo_0990 14 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 150401673 Nonpathogen - peptidyl-tRNA hydrolase Maeo_1251 34 COG1990 COG1990, Uncharacterized conserved protein Function unknown 150400894 Common - pyruvate/ketoisovalerate oxidoreductase, gamma subunit Maeo_0462 74 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 150400960 Nonpathogen - hypothetical protein Maeo_0528 1 None None None 150401257 Nonpathogen - hypothetical protein Maeo_0828 6 None None None 150401090 Common - hypothetical protein Maeo_0660 213 COG1985 RibD, Pyrimidine reductase, riboflavin biosynthesis Coenzyme metabolism 150401565 Common - TrkA-N domain protein Maeo_1142 194 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 150401533 Common gltX glutamyl-tRNA synthetase Maeo_1110 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 150400499 Common - V-type ATP synthase subunit K Maeo_0061 9 None None None 150400713 Common - putative translaldolase Maeo_0278 195 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 150401249 Common - Glycosyltransferase 28 domain-containing protein Maeo_0820 18 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 150401775 Common - hydrogenase subunit F Maeo_1353 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 150401236 Common rpl3p 50S ribosomal protein L3P Maeo_0807 176 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 150400748 Nonpathogen - hypothetical protein Maeo_0314 1 None None None 150400775 Nonpathogen - hypothetical protein Maeo_0342 2 None None None 150401190 Nonpathogen - fibrillarin Maeo_0761 34 COG1889 NOP1, Fibrillarin-like rRNA methylase Translation, ribosomal structure and biogenesis 150400759 Common - Rubrerythrin Maeo_0325 79 COG1592 COG1592, Rubrerythrin Energy production and conversion 150401842 Common - 6-carboxyhexanoate--CoA ligase Maeo_1420 8 COG1424 BioW, Pimeloyl-CoA synthetase Coenzyme metabolism 150400936 Common - protein of unknown function DUF169 Maeo_0504 29 COG2043 COG2043, Uncharacterized protein conserved in archaea Function unknown 150400947 Common - beta-lactamase domain protein Maeo_0515 57 COG1237 COG1237, Metal-dependent hydrolases of the beta-lactamase superfamily II General function prediction only 150401568 Nonpathogen - hypothetical protein Maeo_1145 2 COG3355 COG3355, Predicted transcriptional regulator Transcription 150401448 Common - prephenate dehydrogenase Maeo_1024 145 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 150400471 Common - Phosphomannomutase Maeo_0032 238 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 150401132 Common - translation initiation factor IF-2 subunit alpha Maeo_0703 189 COG1093 SUI2, Translation initiation factor 2, alpha subunit (eIF-2alpha) Translation, ribosomal structure and biogenesis 150400467 Common aspC aspartyl-tRNA synthetase Maeo_0028 249 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 150401728 Common - signal peptidase I Maeo_1306 14 None None None 150401704 Common - pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit Maeo_1282 73 COG1144 COG1144, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit Energy production and conversion 150401756 Nonpathogen - hypothetical protein Maeo_1334 2 COG1627 COG1627, Uncharacterized protein conserved in archaea Function unknown 150401896 Common - putative molybdopterin-guanine dinucleotide biosynthesis protein A Maeo_1474 43 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 150400996 Nonpathogen - 4-vinyl reductase 4VR Maeo_0565 16 COG1719 COG1719, Predicted hydrocarbon binding protein (contains V4R domain) General function prediction only 150400913 Common - protein of unknown function DUF77 Maeo_0481 49 COG0011 COG0011, Uncharacterized conserved protein Function unknown 150401391 Common - SirA family protein Maeo_0967 40 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 150401297 Common - GMP synthase subunit A Maeo_0869 241 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 150400637 Nonpathogen - hypothetical protein Maeo_0199 28 COG1698 COG1698, Uncharacterized protein conserved in archaea Function unknown 150401323 Common - hydrogenase expression/formation protein HypD Maeo_0896 108 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 150401621 Common - O-sialoglycoprotein endopeptidase/protein kinase Maeo_1198 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 150400444 Nonpathogen - ADP-specific phosphofructokinase Maeo_0005 8 COG4809 COG4809, Archaeal ADP-dependent phosphofructokinase/glucokinase Carbohydrate transport and metabolism 150401181 Common - putative methylase Maeo_0752 169 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 150400985 Common - Cobyrinic acid ac-diamide synthase Maeo_0554 33 COG3640 CooC, CO dehydrogenase maturation factor Cell division and chromosome partitioning 150401396 Nonpathogen - hypothetical protein Maeo_0972 1 None None None 150400522 Common - Formylmethanofuran dehydrogenase Maeo_0084 37 COG2218 FwdC, Formylmethanofuran dehydrogenase subunit C Energy production and conversion 150400609 Common - protein of unknown function DUF100 Maeo_0171 37 COG1980 COG1980, Archaeal fructose 1,6-bisphosphatase Carbohydrate transport and metabolism 150401398 Nonpathogen - hypothetical protein Maeo_0974 1 None None None 150400491 Common - Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)-like protein Maeo_0053 8 COG1648 CysG, Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) Coenzyme metabolism 150400611 Common - GMP synthase subunit B Maeo_0173 239 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 150401529 Nonpathogen - hypothetical protein Maeo_1106 1 None None None 150400573 Common - putative RNA methylase Maeo_0135 33 COG4076 COG4076, Predicted RNA methylase General function prediction only 150400724 Common - homoaconitate hydratase family protein Maeo_0289 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 150400632 Common - tyrosyl-tRNA synthetase Maeo_0194 175 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150400997 Common - carbamoyl phosphate synthase small subunit Maeo_0566 233 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 150401046 Nonpathogen - hypothetical protein Maeo_0616 2 COG4029 COG4029, Uncharacterized protein conserved in archaea Function unknown 150401144 Common - signal peptide peptidase SppA, 36K type Maeo_0715 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 150401050 Nonpathogen - GHMP kinase Maeo_0620 29 COG1829 COG1829, Predicted archaeal kinase (sugar kinase superfamily) General function prediction only 150401626 Common - putative signal transduction protein with CBS domains Maeo_1203 199 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 150400768 Common - binding-protein-dependent transport systems inner membrane component Maeo_0334 199 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 150401464 Common - (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase Maeo_1040 124 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 150401498 Nonpathogen - CRISPR-associated protein Cas2 Maeo_1075 14 COG1343 COG1343, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 150401841 Common - 8-amino-7-oxononanoate synthase Maeo_1419 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 150401109 Nonpathogen - Transcription factor CBF/NF-Y histone Maeo_0679 2 COG2036 HHT1, Histones H3 and H4 Chromatin structure and dynamics 150401544 Common - nitrogen regulatory protein P-II Maeo_1121 7 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 150400565 Common - acetylglutamate kinase Maeo_0127 219 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 150401367 Common - hydrogenase, component C-formate hydrogenlyase subunit 4-like protein Maeo_0942 57 COG0650 HyfC, Formate hydrogenlyase subunit 4 Energy production and conversion 150401520 Nonpathogen - 50S ribosomal protein L18e Maeo_1097 34 COG1727 RPL18A, Ribosomal protein L18E Translation, ribosomal structure and biogenesis 150401330 Nonpathogen - hypothetical protein Maeo_0903 3 COG1959 COG1959, Predicted transcriptional regulator Transcription 150400870 Common - DNA topoisomerase VI subunit B Maeo_0438 34 COG1389 COG1389, DNA topoisomerase VI, subunit B DNA replication, recombination, and repair 150401268 Common - Methyltransferase type 11 Maeo_0840 100 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 150401760 Nonpathogen - 30S ribosomal protein S8e Maeo_1338 34 COG2007 RPS8A, Ribosomal protein S8E Translation, ribosomal structure and biogenesis 150400663 Nonpathogen - hypothetical protein Maeo_0225 2 None None None 150401288 Common - formylmethanofuran dehydrogenase subunit E region Maeo_0860 36 COG2191 COG2191, Formylmethanofuran dehydrogenase subunit E Energy production and conversion 150400785 Nonpathogen - hypothetical protein Maeo_0352 2 COG2450 COG2450, Uncharacterized conserved protein Function unknown 150401151 Common - hypothetical protein Maeo_0722 38 COG0348 NapH, Polyferredoxin Energy production and conversion 150400924 Common - Wyosine base formation domain protein Maeo_0492 35 COG0731 COG0731, Fe-S oxidoreductases Energy production and conversion 150400511 Common - orotidine 5'-phosphate decarboxylase Maeo_0073 142 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 150400654 Nonpathogen - hypothetical protein Maeo_0216 2 None None None 150401205 Common - selenocysteine-specific translation elongation factor Maeo_0776 249 COG3276 SelB, Selenocysteine-specific translation elongation factor Translation, ribosomal structure and biogenesis 150401674 Common - cobyric acid synthase Maeo_1252 152 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 150400990 Nonpathogen - membrane-bound metal-dependent hydrolase Maeo_0559 6 None None None 150401327 Common - TrkA-N domain protein Maeo_0900 88 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 150400680 Common - beta-ribofuranosylaminobenzene 5'-phosphate synthase family Maeo_0244 39 COG1907 COG1907, Predicted archaeal sugar kinases General function prediction only 150400586 Common - peptidase M24 Maeo_0148 207 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 150401272 Common - protein of unknown function DUF354 Maeo_0844 22 COG1817 COG1817, Uncharacterized protein conserved in archaea Function unknown 150400645 Common - diaminopimelate decarboxylase Maeo_0207 218 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 150401831 Common - Oligosaccharyl transferase STT3 subunit Maeo_1409 7 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 150401388 Common - DsrE family protein Maeo_0964 20 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 150400614 Nonpathogen - hypothetical protein Maeo_0176 2 COG2892 COG2892, Uncharacterized protein conserved in archaea Function unknown 150401669 Common - PilT protein domain protein Maeo_1247 48 COG1855 COG1855, ATPase (PilT family) General function prediction only 150401910 Nonpathogen - PUA domain containing protein Maeo_1488 23 COG1549 COG1549, Queuine tRNA-ribosyltransferases, contain PUA domain Translation, ribosomal structure and biogenesis 150401530 Common - putative ATP binding related protein Maeo_1107 11 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 150401286 Common - ABC transporter related Maeo_0858 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 150401165 Nonpathogen - FeoA family protein Maeo_0736 1 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 150400813 Common - dTDP-glucose 4,6-dehydratase Maeo_0380 236 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 150401080 Nonpathogen - acylphosphatase Maeo_0650 3 COG1254 AcyP, Acylphosphatases Energy production and conversion 150401901 Common - ammonium transporter Maeo_1479 201 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 150401409 Common - chromosome segregation protein SMC Maeo_0985 194 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 150401439 Common - (R)-2-hydroxyacid dehydrogenase Maeo_1015 67 COG2055 COG2055, Malate/L-lactate dehydrogenases Energy production and conversion 150401353 Common - purine phosphorylase family 2 Maeo_0926 168 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 150401402 Nonpathogen - hypothetical protein Maeo_0978 13 COG4020 COG4020, Uncharacterized protein conserved in archaea Function unknown 150401270 Common - protein of unknown function DUF181 Maeo_0842 47 COG1944 COG1944, Uncharacterized conserved protein Function unknown 150400672 Common - prolyl-tRNA synthetase Maeo_0234 248 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150400794 Nonpathogen - hypothetical protein Maeo_0361 8 COG4038 COG4038, Predicted membrane protein Function unknown 150401829 Common - preprotein translocase subunit SecY Maeo_1407 98 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 150400978 Nonpathogen - UBA/THIF-type NAD/FAD binding protein Maeo_0547 7 COG4015 COG4015, Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family General function prediction only 150401555 Common - glutamyl-tRNA(Gln) amidotransferase subunit E Maeo_1132 208 COG2511 GatE, Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain) Translation, ribosomal structure and biogenesis 150401072 Common - Nucleotidyl transferase Maeo_0642 242 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 150401655 Nonpathogen - hypothetical protein Maeo_1233 3 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 150401302 Common - cobalt-precorrin-6Y C(5)-methyltransferase Maeo_0874 27 COG2241 CobL, Precorrin-6B methylase 1 Coenzyme metabolism 150401087 Common - beta-lactamase domain protein Maeo_0657 175 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 150401590 Nonpathogen - DNA primase, large subunit Maeo_1167 2 COG2219 PRI2, Eukaryotic-type DNA primase, large subunit DNA replication, recombination, and repair 150401679 Common - Xylose isomerase domain protein TIM barrel Maeo_1257 53 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 150401077 Nonpathogen - metal-dependent phosphohydrolase 7TM extracellular region Maeo_0647 1 None None None 150400896 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Maeo_0464 134 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 150400675 Nonpathogen - hypothetical protein Maeo_0239 1 None None None 150401068 Common - TatD-related deoxyribonuclease Maeo_0638 27 COG1831 COG1831, Predicted metal-dependent hydrolase (urease superfamily) General function prediction only 150401732 Nonpathogen - Ribonuclease P Maeo_1310 18 COG1603 RPP1, RNase P/RNase MRP subunit p30 Translation, ribosomal structure and biogenesis 150401057 Nonpathogen - glyceraldehyde-3-phosphate dehydrogenase Maeo_0627 34 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 150401022 Nonpathogen - hypothetical protein Maeo_0591 9 COG4051 COG4051, Uncharacterized protein conserved in archaea Function unknown 150401019 Common - cytochrome c biogenesis protein transmembrane region Maeo_0588 167 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 150401867 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase Maeo_1445 171 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 150401647 Common - phage integrase family protein Maeo_1225 201 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 150401805 Common - protein of unknown function DUF52 Maeo_1383 68 COG1355 COG1355, Predicted dioxygenase General function prediction only 150401689 Nonpathogen - Methyl-coenzyme M reductase, gamma subunit Maeo_1267 14 COG4057 McrG, Methyl coenzyme M reductase, gamma subunit Coenzyme metabolism 150401471 Common - beta-lactamase domain protein Maeo_1047 138 COG1782 COG1782, Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain General function prediction only 150401749 Nonpathogen purP 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase Maeo_1327 20 COG1759 COG1759, ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases) General function prediction only 150401717 Common - triphosphoribosyl-dephospho-CoA protein Maeo_1295 31 COG1767 CitG, Triphosphoribosyl-dephospho-CoA synthetase Coenzyme metabolism 150400590 Common - protein of unknown function DUF47 Maeo_0152 8 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 150401859 Common - integral membrane sensor signal transduction histidine kinase Maeo_1437 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 150401870 Common - thiamine pyrophosphate protein domain protein TPP-binding Maeo_1448 219 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 150401713 Nonpathogen - hypothetical protein Maeo_1291 6 COG4019 COG4019, Uncharacterized protein conserved in archaea Function unknown 150400737 Common - Heavy metal transport/detoxification protein Maeo_0303 20 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 150400692 Nonpathogen - flagellin protein Maeo_0257 7 COG1681 FlaB, Archaeal flagellins Cell motility and secretion 150401199 Nonpathogen - protein of unknown function DUF107 Maeo_0770 6 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 150400840 Common - ATPase associated with various cellular activities AAA_3 Maeo_0408 182 COG0714 COG0714, MoxR-like ATPases General function prediction only 150401118 Nonpathogen - Resolvase helix-turn-helix domain protein Maeo_0688 2 COG4189 COG4189, Predicted transcriptional regulator Transcription 150401434 Nonpathogen nusG transcription antitermination protein NusG Maeo_1010 34 COG0250 NusG, Transcription antiterminator Transcription 150400877 Common - protein of unknown function UPF0118 Maeo_0445 103 COG0628 PerM, Predicted permease General function prediction only 150401410 Common - adenylosuccinate lyase Maeo_0986 237 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 150401635 Nonpathogen - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_1212 37 COG1148 HdrA, Heterodisulfide reductase, subunit A and related polyferredoxins Energy production and conversion 150401422 Nonpathogen - hypothetical protein Maeo_0998 33 COG2118 COG2118, DNA-binding protein General function prediction only 150401753 Common - Auxin Efflux Carrier Maeo_1331 130 COG0679 COG0679, Predicted permeases General function prediction only 150401541 Common - anthranilate synthase component II Maeo_1118 240 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 150400464 Common - beta-lactamase domain protein Maeo_0025 159 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 150401894 Common - iron dependent repressor Maeo_1472 108 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 150400616 Nonpathogen - RNA polymerase Rbp10 Maeo_0178 4 COG1996 RPC10, DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger) Transcription 150401066 Nonpathogen - protein of unknown function Met10 Maeo_0636 34 COG2520 COG2520, Predicted methyltransferase General function prediction only 150401134 Nonpathogen - Protein of unknown function DUF530 Maeo_0705 5 COG1771 COG1771, Uncharacterized protein conserved in archaea Function unknown 150401795 Common - dihydroorotate dehydrogenase electron transfer subunit Maeo_1373 112 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 150400638 Nonpathogen - 30S ribosomal protein S6e Maeo_0200 34 COG2125 RPS6A, Ribosomal protein S6E (S10) Translation, ribosomal structure and biogenesis 150401613 Nonpathogen - hypothetical protein Maeo_1190 7 COG1563 COG1563, Predicted subunit of the Multisubunit Na+/H+ antiporter Inorganic ion transport and metabolism 150400833 Common - rfaE bifunctional protein Maeo_0401 149 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 150400732 Nonpathogen - hypothetical protein Maeo_0298 2 None None None 150401876 Common - Radical SAM domain protein Maeo_1454 64 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 150400963 Nonpathogen - hypothetical protein Maeo_0531 7 None None None 150401229 Common - Radical SAM domain protein Maeo_0800 232 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 150401394 Common - hydroxylamine reductase Maeo_0970 74 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 150401725 Common - coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein Maeo_1303 38 COG1035 FrhB, Coenzyme F420-reducing hydrogenase, beta subunit Energy production and conversion 150401572 Nonpathogen - protein of unknown function DUF201 Maeo_1149 14 COG2232 COG2232, Predicted ATP-dependent carboligase related to biotin carboxylase General function prediction only 150400452 Nonpathogen rpl10e 50S ribosomal protein L10e Maeo_0013 34 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 150401507 Nonpathogen - hypothetical protein Maeo_1084 1 None None None 150400607 Common hisE phosphoribosyl-ATP pyrophosphatase Maeo_0169 162 COG0140 HisI, Phosphoribosyl-ATP pyrophosphohydrolase Amino acid transport and metabolism 150400824 Nonpathogen - hypothetical protein Maeo_0392 7 COG4906 COG4906, Predicted membrane protein Function unknown 150401765 Common - hypothetical protein Maeo_1343 114 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 150401238 Common - protein of unknown function DUF368 Maeo_0809 50 COG2035 COG2035, Predicted membrane protein Function unknown 150401645 Nonpathogen - hypothetical protein Maeo_1223 1 COG5336 COG5336, Uncharacterized protein conserved in bacteria Function unknown 150400916 Common - UDP-glucose/GDP-mannose dehydrogenase Maeo_0484 207 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 150400702 Common - type II secretion system protein E Maeo_0267 226 COG0630 VirB11, Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis Cell motility and secretion / Intracellular trafficking and secretion 150401242 Nonpathogen - hypothetical protein Maeo_0813 36 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 150400939 Common - oxidoreductase/nitrogenase component 1 Maeo_0507 28 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 150401657 Nonpathogen - hypothetical protein Maeo_1235 1 None None None 150401010 Common - carbonic anhydrase Maeo_0579 51 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 150400581 Common - cobalt ABC transporter, ATPase subunit Maeo_0143 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 150400754 Common - Archaeoflavoprotein AfpA Maeo_0320 18 COG1036 COG1036, Archaeal flavoproteins Energy production and conversion 150400962 Nonpathogen - hypothetical protein Maeo_0530 1 None None None 150401259 Common - precorrin-3B C17-methyltransferase Maeo_0830 121 COG1010 CobJ, Precorrin-3B methylase Coenzyme metabolism 150401576 Nonpathogen - hypothetical protein Maeo_1153 4 COG1955 FlaJ, Archaeal flagella assembly protein J Cell motility and secretion / Intracellular trafficking and secretion 150401173 Common - uridylate kinase, putative Maeo_0744 247 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 150401355 Common - hypothetical protein Maeo_0929 17 COG2603 COG2603, Predicted ATPase General function prediction only 150401372 Common - hypothetical protein Maeo_0947 10 COG2361 COG2361, Uncharacterized conserved protein Function unknown 150401465 Common - anaerobic ribonucleoside-triphosphate reductase Maeo_1041 106 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 150400538 Common - molybdopterin oxidoreductase Maeo_0100 126 COG1029 FwdB, Formylmethanofuran dehydrogenase subunit B Energy production and conversion 150401250 Common - Putative cell wall-binding domain-like protein Maeo_0821 7 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 150401535 Nonpathogen - hypothetical protein Maeo_1112 1 None None None 150401770 Common - hypothetical protein Maeo_1348 10 COG3672 COG3672, Predicted periplasmic protein Function unknown 150401442 Common - conserved hypothetical protein 374 Maeo_1018 29 COG0392 COG0392, Predicted integral membrane protein Function unknown 150400773 Nonpathogen - hypothetical protein Maeo_0340 2 None None None 150401156 Common - ribonuclease Z Maeo_0727 115 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 150401603 Common - cobalamin 5'-phosphate synthase Maeo_1180 20 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 150401802 Common - peptidase M50 Maeo_1380 14 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 150400847 Common - NAD-dependent epimerase/dehydratase Maeo_0415 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 150401624 Common - PfkB domain protein Maeo_1201 154 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 150400776 Common - hypothetical protein Maeo_0343 33 COG2122 COG2122, Uncharacterized conserved protein Function unknown 150401772 Common - peptidase S16, Lon-like protease Maeo_1350 202 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 150401247 Nonpathogen - GTP cyclohydrolase III Maeo_0818 16 COG2429 COG2429, Uncharacterized conserved protein Function unknown 150400661 Nonpathogen - Helix-turn-helix type 11 domain protein Maeo_0223 23 COG1497 COG1497, Predicted transcriptional regulator Transcription 150401135 Common - cobalamin biosynthesis protein CobD Maeo_0706 149 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 150401036 Common - dihydropteroate synthase-related protein Maeo_0605 37 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 150401274 Nonpathogen - hypothetical protein Maeo_0846 3 COG4024 COG4024, Uncharacterized protein conserved in archaea Function unknown 150401306 Common - archaeosine tRNA-ribosyltransferase Maeo_0878 230 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 150401291 Common hisD histidinol dehydrogenase Maeo_0863 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 150400969 Nonpathogen - hypothetical protein Maeo_0538 1 None None None 150401473 Common thyA thymidylate synthase Maeo_1049 60 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 150400788 Nonpathogen - ZPR1-related zinc finger protein Maeo_0355 29 COG1779 COG1779, C4-type Zn-finger protein General function prediction only 150401579 Nonpathogen - H/ACA RNA-protein complex component Gar1 Maeo_1156 1 COG3277 GAR1, RNA-binding protein involved in rRNA processing Translation, ribosomal structure and biogenesis 150400946 Nonpathogen - Protein of unknown function DUF650 Maeo_0514 32 COG1602 COG1602, Uncharacterized conserved protein Function unknown 150400629 Nonpathogen - conserved hypothetical cytosolic protein Maeo_0191 3 None None None 150400626 Nonpathogen rplP0 acidic ribosomal protein P0 Maeo_0188 33 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 150400456 Common - protein of unknown function DUF190 Maeo_0017 28 COG1993 COG1993, Uncharacterized conserved protein Function unknown 150401450 Common - biotin synthase Maeo_1026 88 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 150400811 Common - NAD-dependent epimerase/dehydratase Maeo_0378 234 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 150400906 Nonpathogen - acetyl-CoA decarbonylase/synthase complex subunit epsilon Maeo_0474 10 COG1880 CdhB, CO dehydrogenase/acetyl-CoA synthase epsilon subunit Energy production and conversion 150400493 Nonpathogen - Protein of unknown function DUF655 Maeo_0055 33 COG1491 COG1491, Predicted RNA-binding protein Translation, ribosomal structure and biogenesis 150401869 Nonpathogen - hypothetical protein Maeo_1447 9 COG4069 COG4069, Uncharacterized protein conserved in archaea Function unknown 150401374 Common - DNA polymerase beta domain protein region Maeo_0949 29 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 150400544 Nonpathogen - nucleoside recognition domain protein Maeo_0106 16 COG3366 COG3366, Uncharacterized protein conserved in archaea Function unknown 150401855 Common - nitrogen regulatory protein P-II Maeo_1433 181 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 150401928 Nonpathogen - hypothetical protein Maeo_1506 2 None None None 150401798 Common cysS cysteinyl-tRNA synthetase Maeo_1376 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150400502 Common - V-type ATP synthase subunit F Maeo_0064 14 COG1436 NtpG, Archaeal/vacuolar-type H+-ATPase subunit F Energy production and conversion 150401681 Common - flavodoxin Maeo_1259 12 COG0716 FldA, Flavodoxins Energy production and conversion 150400446 Common - glycosyl transferase group 1 Maeo_0007 144 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 150401415 Common - ABC transporter related Maeo_0991 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 150400701 Common - flagellar accessory protein FlaH Maeo_0266 25 COG2874 FlaH, Predicted ATPases involved in biogenesis of archaeal flagella Cell motility and secretion / Intracellular trafficking and secretion 150401325 Common - CBS domain containing protein Maeo_0898 153 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 150400888 Common - permease Maeo_0456 66 COG0701 COG0701, Predicted permeases General function prediction only 150401480 Common - major facilitator superfamily MFS_1 Maeo_1056 142 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 150401702 Nonpathogen - Protein of unknown function DUF54 Maeo_1280 16 COG1325 COG1325, Predicted exosome subunit Translation, ribosomal structure and biogenesis 150401821 Common rps8p 30S ribosomal protein S8P Maeo_1399 210 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 150400938 Common - nitrogenase reductase-like protein Maeo_0506 151 COG1348 NifH, Nitrogenase subunit NifH (ATPase) Inorganic ion transport and metabolism 150401860 Common - Radical SAM domain protein Maeo_1438 34 COG1031 COG1031, Uncharacterized Fe-S oxidoreductase Energy production and conversion 150401338 Common cofG FO synthase subunit 1 Maeo_0911 51 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 150400745 Common - 3-isopropylmalate dehydratase Maeo_0311 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 150400469 Common hisS histidyl-tRNA synthetase Maeo_0030 249 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150400454 Common cbiC precorrin-8X methylmutase Maeo_0015 119 COG2082 CobH, Precorrin isomerase Coenzyme metabolism 150400875 Common gatB aspartyl/glutamyl-tRNA amidotransferase subunit B Maeo_0443 214 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 150401030 Common - Uroporphyrinogen-III decarboxylase-like protein Maeo_0599 10 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 150401561 Common - protein of unknown function DUF192 Maeo_1138 10 COG1430 COG1430, Uncharacterized conserved protein Function unknown 150401025 Common - Non-specific serine/threonine protein kinase Maeo_0594 65 COG1718 RIO1, Serine/threonine protein kinase involved in cell cycle control Signal transduction mechanisms / Cell division and chromosome partitioning 150401217 Common - DNA-directed RNA polymerase subunit A'' Maeo_0788 246 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 150400513 Common - Uroporphyrinogen III synthase HEM4 Maeo_0075 46 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 150400535 Common - nickel-dependent hydrogenase large subunit Maeo_0097 111 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 150401188 Common rps2P 30S ribosomal protein S2 Maeo_0759 111 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 150400926 Nonpathogen - hypothetical protein Maeo_0494 2 None None None 150400665 Nonpathogen - hypothetical protein Maeo_0227 4 COG5543 COG5543, Uncharacterized conserved protein Function unknown 150401721 Common - orotate phosphoribosyltransferase Maeo_1299 29 COG0856 COG0856, Orotate phosphoribosyltransferase homologs Nucleotide transport and metabolism 150400898 Common - carbamoyl phosphate synthase small subunit Maeo_0466 236 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 150401762 Nonpathogen - hypothetical protein Maeo_1340 9 COG2456 COG2456, Uncharacterized conserved protein Function unknown 150401212 Common - elongation factor EF-2 Maeo_0783 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 150401412 Common - helicase, putative Maeo_0988 4 None None None 150400783 Common - cell division ATPase MinD Maeo_0350 191 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 150401924 Nonpathogen - NMD3 Maeo_1502 33 COG1499 NMD3, NMD protein affecting ribosome stability and mRNA decay Translation, ribosomal structure and biogenesis 150401281 Nonpathogen - hypothetical protein Maeo_0853 5 COG5306 COG5306, Uncharacterized conserved protein Function unknown 150400752 Common - SufBD protein Maeo_0318 188 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 150401163 Common - glycosyl transferase family 2 Maeo_0734 131 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 150401207 Common - nitrite and sulphite reductase 4Fe-4S region Maeo_0778 78 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 150401386 Nonpathogen - hypothetical protein Maeo_0962 2 None None None 150401016 Common - hypothetical protein Maeo_0585 14 COG4997 COG4997, Uncharacterized conserved protein Function unknown 150401126 Nonpathogen - hypothetical protein Maeo_0697 5 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 150400642 Common - Diaminopimelate epimerase Maeo_0204 202 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 150400548 Nonpathogen - hypothetical protein Maeo_0110 1 COG3366 COG3366, Uncharacterized protein conserved in archaea Function unknown 150401527 Nonpathogen - protein of unknown function DUF125 transmembrane Maeo_1104 8 COG1814 COG1814, Uncharacterized membrane protein Function unknown 150401146 Common - succinate dehydrogenase/fumarate reductase iron-sulfur subunit Maeo_0717 223 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 150400630 Common - DNA methylase N-4/N-6 domain protein Maeo_0192 98 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 150401183 Common - putative signal transduction protein with CBS domains Maeo_0754 106 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 150401092 Common - NAD+ synthetase Maeo_0662 236 COG0171 NadE, NAD synthase Coenzyme metabolism 150401847 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Maeo_1425 100 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 150401700 Nonpathogen - Protein of unknown function DUF749 Maeo_1278 5 COG4009 COG4009, Uncharacterized protein conserved in archaea Function unknown 150401107 Common - putative signal transduction protein with CBS domains Maeo_0677 156 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 150400488 Common - Proteasome endopeptidase complex Maeo_0050 48 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 150401542 Common - N-(5'-phosphoribosyl)anthranilate isomerase Maeo_1119 165 COG0135 TrpF, Phosphoribosylanthranilate isomerase Amino acid transport and metabolism 150401048 Common - thymidine phosphorylase Maeo_0618 179 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 150400599 Nonpathogen - hypothetical protein Maeo_0161 1 None None None 150401342 Common - translation initiation factor IF-5A Maeo_0915 36 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 150400563 Nonpathogen - translation initiation factor IF-6 Maeo_0125 32 COG1976 TIF6, Translation initiation factor 6 (eIF-6) Translation, ribosomal structure and biogenesis 150400460 Common - acetyl-CoA acetyltransferase Maeo_0021 125 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 150400689 Common - band 7 protein Maeo_0253 217 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 150401369 Common valS valyl-tRNA synthetase Maeo_0944 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150401780 Common - ferredoxin Maeo_1358 26 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 150400953 Common - ABC transporter related Maeo_0521 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 150401734 Common - replication factor C small subunit Maeo_1312 214 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 150401557 Nonpathogen - hypothetical protein Maeo_1134 18 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 150401503 Common - CRISPR-associated RAMP protein, Csm4 family Maeo_1080 10 COG1567 COG1567, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 150401060 Common - CBS domain containing protein Maeo_0630 133 COG0517 COG0517, FOG: CBS domain General function prediction only 150400779 Common - threonine synthase Maeo_0346 222 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 150401147 Common - 3-hydroxy-3-methylglutaryl Coenzyme A reductase Maeo_0718 67 COG1257 HMG1, Hydroxymethylglutaryl-CoA reductase Lipid metabolism 150400568 Nonpathogen - hypothetical protein Maeo_0130 1 None None None 150401049 Common metG methionyl-tRNA synthetase Maeo_0619 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150400885 Common - ABC transporter related Maeo_0453 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 150401490 Nonpathogen - hypothetical protein Maeo_1066 5 None None None 150400596 Common truA tRNA pseudouridine synthase A Maeo_0158 107 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 150400579 Common - Imidazoleglycerol-phosphate dehydratase Maeo_0141 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 150400735 Common - ABC transporter related Maeo_0301 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 150401922 Nonpathogen - 50S ribosomal protein L15e Maeo_1500 34 COG1632 RPL15A, Ribosomal protein L15E Translation, ribosomal structure and biogenesis 150401637 Common - NADH ubiquinone oxidoreductase 20 kDa subunit Maeo_1214 52 COG1941 FrhG, Coenzyme F420-reducing hydrogenase, gamma subunit Energy production and conversion 150400927 Common pgk phosphoglycerate kinase Maeo_0495 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 150401719 Common - hypothetical protein Maeo_1297 60 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 150401179 Common - FO synthase subunit 2 Maeo_0750 84 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 150401650 Nonpathogen - hypothetical protein Maeo_1228 2 COG1733 COG1733, Predicted transcriptional regulators Transcription 150401769 Common - putative CoA-substrate-specific enzyme activase Maeo_1347 60 COG1924 COG1924, Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) Lipid metabolism 150401420 Common - protein of unknown function UPF0044 Maeo_0996 71 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 150401059 Common - fumarate hydratase Maeo_0629 147 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 150401715 Common - conserved hypothetical radical SAM protein Maeo_1293 87 COG1242 COG1242, Predicted Fe-S oxidoreductase General function prediction only 150401872 Common - translation-associated GTPase Maeo_1450 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 150401099 Common - hypothetical protein Maeo_0669 24 COG1901 COG1901, Uncharacterized conserved protein Function unknown 150401002 Common - phosphate ABC transporter, inner membrane subunit PstA Maeo_0571 225 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 150401158 Common - putative signal transduction protein with CBS domains Maeo_0729 68 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 150400907 Common - acetyl-CoA decarbonylase/synthase complex subunit alpha Maeo_0475 21 COG1152 CdhA, CO dehydrogenase/acetyl-CoA synthase alpha subunit Energy production and conversion 150400722 Common - ABC transporter related Maeo_0287 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 150401649 Nonpathogen - hypothetical protein Maeo_1227 1 None None None 150400699 Nonpathogen - flagellar protein F Maeo_0264 2 COG3353 FlaF, Putative archaeal flagellar protein F Cell motility and secretion 150401085 Nonpathogen - PHP domain protein Maeo_0655 10 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 150401879 Common - putative RNA methylase, NOL1/NOP2/sun family Maeo_1457 197 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 150401793 Common - putative undecaprenol kinase Maeo_1371 201 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 150400793 Nonpathogen - hypothetical protein Maeo_0360 6 COG4039 COG4039, Predicted membrane protein Function unknown 150400976 Common - Exonuclease RNase T and DNA polymerase III Maeo_0545 8 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 150401915 Common - peptidase U62 modulator of DNA gyrase Maeo_1493 96 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 150400584 Common - cobalt transport protein CbiM Maeo_0146 66 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 150401881 Common - phosphoribosylformylglycinamidine synthase II Maeo_1459 233 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 150401024 Nonpathogen - KH type 1 domain protein Maeo_0593 34 COG1094 COG1094, Predicted RNA-binding protein (contains KH domains) General function prediction only 150401111 Common - Sep-tRNA:Cys-tRNA synthetase Maeo_0681 46 COG1103 COG1103, Archaea-specific pyridoxal phosphate-dependent enzymes General function prediction only 150400656 Nonpathogen - Protein of unknown function DUF128 Maeo_0218 16 COG1693 COG1693, Uncharacterized protein conserved in archaea Function unknown 150400766 Nonpathogen - Carboxymuconolactone decarboxylase Maeo_0332 9 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 150400473 Common - Acetyl coenzyme A synthetase (ADP forming) alpha domain Maeo_0034 151 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 150401070 Common - acetylornithine and succinylornithine aminotransferase Maeo_0640 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 150401429 Common - pyruvate carboxylase subunit B Maeo_1005 206 COG5016 COG5016, Pyruvate/oxaloacetate carboxyltransferase Energy production and conversion 150401304 Nonpathogen - FUN14 family protein Maeo_0876 5 COG2383 COG2383, Uncharacterized conserved protein Function unknown 150401744 Common - phosphoribosylamine--glycine ligase Maeo_1322 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 150401052 Common - argininosuccinate synthase Maeo_0622 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 150400900 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase Maeo_0468 176 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 150401796 Common - hypothetical protein Maeo_1374 71 COG1750 COG1750, Archaeal serine proteases General function prediction only 150400495 Nonpathogen - 50S ribosomal protein L21e Maeo_0057 34 COG2139 RPL21A, Ribosomal protein L21E Translation, ribosomal structure and biogenesis 150401779 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_1357 90 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 150400822 Common - glycosyl transferase family 2 Maeo_0390 80 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 150401380 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0956 69 COG0348 NapH, Polyferredoxin Energy production and conversion 150401357 Common - methionine synthase Maeo_0931 138 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 150401767 Common - phosphate binding protein Maeo_1345 142 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 150401230 Common - small GTP-binding protein Maeo_0801 70 COG1084 COG1084, Predicted GTPase General function prediction only 150401231 Common - plasma-membrane proton-efflux P-type ATPase Maeo_0802 232 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 150401574 Common - metal dependent phosphohydrolase Maeo_1151 23 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 150400704 Nonpathogen - Peptidase A24B, FlaK-like protein Maeo_0269 2 COG4960 CpaA, Flp pilus assembly protein, protease CpaA Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 150400786 Nonpathogen - hypothetical protein Maeo_0353 14 COG4022 COG4022, Uncharacterized protein conserved in archaea Function unknown 150400448 Nonpathogen - hypothetical protein Maeo_0009 3 None None None 150400556 Common - ABC-type Fe3+-hydroxamate transport system periplasmic component-like protein Maeo_0118 22 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 150401170 Nonpathogen - DNA primase Maeo_0741 34 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 150400651 Nonpathogen - transcription termination factor Tfs Maeo_0213 33 COG1594 RPB9, DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS Transcription 150401605 Common - nickel responsive regulator Maeo_1182 66 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 150400918 Nonpathogen - hypothetical protein Maeo_0486 2 None None None 150401550 Common - cytidylate kinase Maeo_1127 35 COG1102 Cmk, Cytidylate kinase Nucleotide transport and metabolism 150401103 Common - translation initiation factor IF-2B subunit delta Maeo_0673 132 COG1184 GCD2, Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 150400932 Nonpathogen - hypothetical protein Maeo_0500 3 None None None 150401660 Nonpathogen - hypothetical protein Maeo_1238 1 COG4371 COG4371, Predicted membrane protein Function unknown 150401370 Common ileS isoleucyl-tRNA synthetase Maeo_0945 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150401444 Common - hydrogenase accessory protein HypB Maeo_1020 154 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 150400526 Common - cobalt ABC transporter, inner membrane subunit CbiQ Maeo_0088 57 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 150401509 Common - elongation factor Tu domain 2 protein Maeo_1086 142 COG3276 SelB, Selenocysteine-specific translation elongation factor Translation, ribosomal structure and biogenesis 150400475 Common - cobalamin (vitamin B12) biosynthesis CbiG protein Maeo_0036 72 COG2073 CbiG, Cobalamin biosynthesis protein CbiG Coenzyme metabolism 150401053 Common - Hydantoinase/oxoprolinase Maeo_0623 24 COG1548 COG1548, Predicted transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 150401392 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0968 70 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 150401009 Common - formate dehydrogenase, alpha subunit Maeo_0578 204 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 150400577 Nonpathogen - phosphoesterase RecJ domain protein Maeo_0139 27 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 150401736 Common argC N-acetyl-gamma-glutamyl-phosphate reductase Maeo_1314 214 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 150401615 Common - aminotransferase class I and II Maeo_1192 239 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 150401663 Nonpathogen - hypothetical protein Maeo_1241 1 None None None 150401227 Common - putative thiazole biosynthetic enzyme Maeo_0798 34 COG1635 THI4, Flavoprotein involved in thiazole biosynthesis Coenzyme metabolism 150400981 Nonpathogen - hypothetical protein Maeo_0550 1 None None None 150401017 Common - Radical SAM domain protein Maeo_0586 68 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 150400965 Nonpathogen - hypothetical protein Maeo_0533 1 None None None 150401639 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_1217 123 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 150400450 Common - Alpha-amylase Maeo_0011 24 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 150401570 Common - regulatory protein ArsR Maeo_1147 14 COG1474 CDC6, Cdc6-related protein, AAA superfamily ATPase DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones 150400806 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0373 77 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 150400851 Common - Fe-S oxidoreductase-like protein Maeo_0419 50 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 150401240 Common - protein of unknown function DUF89 Maeo_0811 41 COG1578 COG1578, Uncharacterized conserved protein Function unknown 150401105 Common - (R)-citramalate synthase Maeo_0675 220 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 150401583 Common truD tRNA pseudouridine synthase D Maeo_1160 85 COG0585 COG0585, Uncharacterized conserved protein Function unknown 150401076 Nonpathogen - hypothetical protein Maeo_0646 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 150400988 Common - peptidase U62 modulator of DNA gyrase Maeo_0557 170 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 150400714 Common - histone acetyltransferase, ELP3 family Maeo_0279 88 COG1243 ELP3, Histone acetyltransferase Transcription / Chromatin structure and dynamics 150401817 Nonpathogen rpl24p 50S ribosomal protein L24P Maeo_1395 34 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 150400504 Common - V-type ATP synthase subunit B Maeo_0066 247 COG1156 NtpB, Archaeal/vacuolar-type H+-ATPase subunit B Energy production and conversion 150401857 Nonpathogen - domain of unknown function DUF1745 Maeo_1435 10 COG3287 COG3287, Uncharacterized conserved protein Function unknown 150401862 Common - Cobyrinic acid ac-diamide synthase Maeo_1440 110 COG3640 CooC, CO dehydrogenase maturation factor Cell division and chromosome partitioning 150401340 Nonpathogen - Ribonuclease P-related Maeo_0913 14 COG1369 POP5, RNase P/RNase MRP subunit POP5 Translation, ribosomal structure and biogenesis 150401311 Common - dethiobiotin synthase Maeo_0883 157 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 150401310 Nonpathogen - putative DNA primase, small subunit Maeo_0882 32 COG1467 PRI1, Eukaryotic-type DNA primase, catalytic (small) subunit DNA replication, recombination, and repair 150400690 Common - nicotinamide-nucleotide adenylyltransferase Maeo_0254 47 COG1056 NadR, Nicotinamide mononucleotide adenylyltransferase Coenzyme metabolism 150401020 Common - Thioredoxin domain Maeo_0589 230 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 150401197 Common - Tetratricopeptide TPR_2 repeat protein Maeo_0768 131 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 150400706 Common - phosphoenolpyruvate synthase Maeo_0271 236 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 150401694 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit B Maeo_1272 8 COG4062 MtrB, Tetrahydromethanopterin S-methyltransferase, subunit B Coenzyme metabolism 150401008 Common - coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein Maeo_0577 36 COG1035 FrhB, Coenzyme F420-reducing hydrogenase, beta subunit Energy production and conversion 150401519 Nonpathogen rpl13p 50S ribosomal protein L13P Maeo_1096 35 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 150401486 Nonpathogen - hypothetical protein Maeo_1062 1 None None None 150401400 Common - hypothetical protein Maeo_0976 2 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 150400640 Nonpathogen - hypothetical protein Maeo_0202 22 COG2266 COG2266, GTP:adenosylcobinamide-phosphate guanylyltransferase Coenzyme metabolism 150400624 Nonpathogen - transcription factor Maeo_0186 34 COG2101 SPT15, TATA-box binding protein (TBP), component of TFIID and TFIIIB Transcription 150400865 Common - Phosphoglucosamine mutase Maeo_0433 243 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 150401276 Common - L-aspartate dehydrogenase Maeo_0848 50 COG1712 COG1712, Predicted dinucleotide-utilizing enzyme General function prediction only 150401137 Nonpathogen - phosphoesterase PA-phosphatase related Maeo_0708 2 None None None 150401755 Nonpathogen - hypothetical protein Maeo_1333 2 None None None 150401362 Common - hypothetical protein Maeo_0936 22 COG3586 COG3586, Uncharacterized conserved protein Function unknown 150401898 Common moaA molybdenum cofactor biosynthesis protein A Maeo_1476 207 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 150401308 Nonpathogen - Uncharacterised conserved protein UCP006577 Maeo_0880 13 COG4033 COG4033, Uncharacterized protein conserved in archaea Function unknown 150401037 Nonpathogen rps15p 30S ribosomal protein S15P Maeo_0606 34 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 150401309 Nonpathogen - hypothetical protein Maeo_0881 10 COG4081 COG4081, Uncharacterized protein conserved in archaea Function unknown 150400743 Common - cobyrinic acid a,c-diamide synthase Maeo_0309 136 COG1797 CobB, Cobyrinic acid a,c-diamide synthase Coenzyme metabolism 150400627 Common rpl1P 50S ribosomal protein L1P Maeo_0189 247 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 150400835 Common - mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase Maeo_0403 164 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 150401084 Common - amidohydrolase Maeo_0654 162 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 150400944 Common - Radical SAM domain protein Maeo_0512 136 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 150401516 Nonpathogen - RNA polymerase Rpb6 Maeo_1093 2 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 150401907 Common - tryptophanyl-tRNA synthetase Maeo_1485 222 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150401452 Nonpathogen - fibrillarin protein-like protein Maeo_1028 7 COG4018 COG4018, Uncharacterized protein conserved in archaea Function unknown 150401810 Common rpl22p 50S ribosomal protein L22P Maeo_1388 66 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 150401884 Common - molybdopterin oxidoreductase Maeo_1462 120 COG1029 FwdB, Formylmethanofuran dehydrogenase subunit B Energy production and conversion 150401562 Common - protein of unknown function DUF114 Maeo_1139 40 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 150401454 Common - aldehyde dehydrogenase Maeo_1030 223 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 150401684 Common - protein of unknown function DUF512 Maeo_1262 22 COG1625 COG1625, Fe-S oxidoreductase, related to NifB/MoaA family Energy production and conversion 150400805 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0372 106 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 150400891 Common - transposase, IS605 OrfB family Maeo_0459 77 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 150400605 Common - ribose-phosphate pyrophosphokinase Maeo_0167 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 150400919 Nonpathogen - hypothetical protein Maeo_0487 3 None None None 150400741 Common - CoB--CoM heterodisulfide reductase Maeo_0307 40 COG1150 HdrC, Heterodisulfide reductase, subunit C Energy production and conversion 150401690 Nonpathogen - Coenzyme-B sulfoethylthiotransferase Maeo_1268 14 COG4058 McrA, Methyl coenzyme M reductase, alpha subunit Coenzyme metabolism 150401757 Common - ABC transporter related Maeo_1335 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 150401344 Nonpathogen - hypothetical protein Maeo_0917 2 None None None 150401336 Nonpathogen rps17E 30S ribosomal protein S17e Maeo_0909 34 COG1383 RPS17A, Ribosomal protein S17E Translation, ribosomal structure and biogenesis 150400578 Common - TPR repeat-containing protein Maeo_0140 26 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 150401580 Nonpathogen - hypothetical protein Maeo_1157 5 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 150401298 Common - methionine aminopeptidase Maeo_0870 189 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 150401361 Nonpathogen - peptidase-like protein Maeo_0935 3 COG4960 CpaA, Flp pilus assembly protein, protease CpaA Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 150401483 Common - hypothetical protein Maeo_1059 26 COG3044 COG3044, Predicted ATPase of the ABC class General function prediction only 150400941 Common - Methyltransferase type 11 Maeo_0509 190 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 150401889 Common - thiamine pyrophosphate protein domain protein TPP-binding Maeo_1467 113 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 150401878 Nonpathogen - hypothetical protein Maeo_1456 2 COG4083 COG4083, Predicted membrane protein Function unknown 150401102 Common - putative signal-transduction protein with CBS domains Maeo_0672 118 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 150400449 Common - glycoside hydrolase 15-related Maeo_0010 32 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 150401619 Nonpathogen - zinc finger SWIM domain protein Maeo_1196 5 COG4715 COG4715, Uncharacterized conserved protein Function unknown 150401123 Nonpathogen - H(2)-dependent methylenetetrahydromethanopterin dehydrogenase-related protein Maeo_0693 6 COG4007 COG4007, Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase General function prediction only 150401195 Common - thioredoxin reductase Maeo_0766 249 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 150401074 Nonpathogen - Protein of unknown function DUF372 Maeo_0644 20 COG2098 COG2098, Uncharacterized protein conserved in archaea Function unknown 150400974 Nonpathogen - hypothetical protein Maeo_0543 3 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 150400873 Common - N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase Maeo_0441 27 COG3252 COG3252, Methenyltetrahydromethanopterin cyclohydrolase Coenzyme metabolism 150401512 Common - SNARE associated Golgi protein Maeo_1089 12 COG1238 COG1238, Predicted membrane protein Function unknown 150401920 Common - 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase Maeo_1498 180 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 150401820 Nonpathogen rps14P 30S ribosomal protein S14P Maeo_1398 33 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 150400846 Common - UDP-glucose 6-dehydrogenase Maeo_0414 209 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 150400587 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Maeo_0149 236 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 150401484 Common - O-phosphoseryl-tRNA synthetase Maeo_1060 65 COG2024 COG2024, Phenylalanyl-tRNA synthetase alpha subunit (archaeal type) Translation, ribosomal structure and biogenesis 150401893 Nonpathogen - hypothetical protein Maeo_1471 2 None None None 150401883 Nonpathogen - hypothetical protein Maeo_1461 1 None None None 150400562 Nonpathogen - Ribosomal LX protein Maeo_0124 15 COG2157 RPL20A, Ribosomal protein L20A (L18A) Translation, ribosomal structure and biogenesis 150401479 Common - Radical SAM domain protein Maeo_1055 88 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 150400861 Nonpathogen - hypothetical protein Maeo_0429 1 None None None 150401707 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_1285 178 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 150401316 Nonpathogen - hypothetical protein Maeo_0889 2 None None None 150400557 Common - APHP domain protein Maeo_0119 16 COG1572 COG1572, Uncharacterized conserved protein Function unknown 150401346 Nonpathogen - hypothetical protein Maeo_0919 5 COG5222 COG5222, Uncharacterized conserved protein, contains RING Zn-finger General function prediction only 150400749 Common - triosephosphate isomerase Maeo_0315 42 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 150401322 Nonpathogen nac nascent polypeptide-associated complex protein Maeo_0895 31 COG1308 EGD2, Transcription factor homologous to NACalpha-BTF3 Transcription 150401171 Nonpathogen - Protein of unknown function UPF0058 Maeo_0742 16 COG1745 COG1745, Predicted metal-binding protein General function prediction only 150401825 Nonpathogen rpl18p 50S ribosomal protein L18P Maeo_1403 34 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 150401813 Common - translation initiation factor Sui1 Maeo_1391 74 COG0023 SUI1, Translation initiation factor 1 (eIF-1/SUI1) and related proteins Translation, ribosomal structure and biogenesis 150401902 Common - nitrogen regulatory protein P-II Maeo_1480 186 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 150401797 Common - protein of unknown function UPF0029 Maeo_1375 125 COG1739 COG1739, Uncharacterized conserved protein Function unknown 150400468 Common - protein of unknown function DUF59 Maeo_0029 94 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 150401000 Common - nuclease (SNase domain protein) Maeo_0569 73 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 150400948 Common - anaerobic ribonucleoside-triphosphate reductase activating protein Maeo_0516 103 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 150400443 Nonpathogen - Ribonucleoprotein complex SRP, Srp19 component Maeo_0004 23 COG1400 SEC65, Signal recognition particle 19 kDa protein Intracellular trafficking and secretion 150401662 Nonpathogen - hypothetical protein Maeo_1240 1 None None None 150400935 Common - redox-active disulfide protein 1 Maeo_0503 20 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 150401729 Common - geranylgeranyl reductase Maeo_1307 110 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 150400516 Common - NADPH-dependent FMN reductase Maeo_0078 92 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 150401294 Nonpathogen - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0866 25 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 150400485 Common - heat shock protein Hsp20 Maeo_0047 65 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 150401782 Common - energy conserving hydrogenase B integral membrane subunit Maeo_1360 15 COG0650 HyfC, Formate hydrogenlyase subunit 4 Energy production and conversion 150401850 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_1428 32 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 150401264 Common - succinyl-diaminopimelate desuccinylase Maeo_0836 191 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 150400553 Common - PKD domain containing protein Maeo_0115 19 None None None 150401245 Nonpathogen - polysaccharide deacetylase Maeo_0816 4 COG3233 COG3233, Predicted deacetylase General function prediction only 150400490 Common hemA glutamyl-tRNA reductase Maeo_0052 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 150401225 Common - thiamine biosynthesis/tRNA modification protein ThiI Maeo_0796 96 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 150400498 Common - V-type ATP synthase subunit I Maeo_0060 47 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 150401390 Common - pyridine nucleotide-disulphide oxidoreductase family protein Maeo_0966 49 COG2210 COG2210, Uncharacterized conserved protein Function unknown 150400984 Nonpathogen - Soluble liver antigen/liver pancreas antigen Maeo_0553 3 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 150401038 Common - tRNA methyltransferase complex GCD14 subunit Maeo_0607 61 COG2519 GCD14, tRNA(1-methyladenosine) methyltransferase and related methyltransferases Translation, ribosomal structure and biogenesis 150400470 Nonpathogen - hypothetical protein Maeo_0031 1 None None None 150401567 Common - MCM family protein Maeo_1144 40 COG1241 MCM2, Predicted ATPase involved in replication control, Cdc46/Mcm family DNA replication, recombination, and repair 150400761 Nonpathogen - rubredoxin-like non-heme iron protein Maeo_0327 3 COG1773 COG1773, Rubredoxin Energy production and conversion 150400719 Nonpathogen - Ribosomal protein S27a Maeo_0284 24 COG1998 RPS31, Ribosomal protein S27AE Translation, ribosomal structure and biogenesis 150401629 Nonpathogen - hypothetical protein Maeo_1206 2 None None None 150401505 Nonpathogen - CRISPR-associated protein, Csm2 family Maeo_1082 2 COG1421 COG1421, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 150401697 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit G Maeo_1275 14 COG4064 MtrG, Tetrahydromethanopterin S-methyltransferase, subunit G Coenzyme metabolism 150400827 Common - glycosyl transferase group 1 Maeo_0395 146 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 150401445 Common - peptidase M50 Maeo_1021 57 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 150401252 Common argJ bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein Maeo_0823 167 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 150401790 Nonpathogen - protein of unknown function DUF39 Maeo_1368 28 COG1900 COG1900, Uncharacterized conserved protein Function unknown 150401382 Common - protein tyrosine phosphatase Maeo_0958 63 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 150401104 Common - S-adenosyl-L-homocysteine hydrolase Maeo_0674 177 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 150400753 Common - ABC transporter related Maeo_0319 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 150400730 Common - carbohydrate kinase, YjeF related protein Maeo_0296 156 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 150400850 Common - Acetyltransferase (isoleucine patch superfamily)-like protein Maeo_0418 165 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 150400841 Nonpathogen - hypothetical protein Maeo_0409 3 None None None 150401926 Common - Ribulose-phosphate 3-epimerase Maeo_1504 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 150400837 Common - PKD domain containing protein Maeo_0405 12 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 150401112 Common - acetolactate synthase catalytic subunit Maeo_0682 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 150401552 Nonpathogen - protein of unknown function DUF106 transmembrane Maeo_1129 12 COG1422 COG1422, Predicted membrane protein Function unknown 150401600 Common - hypothetical protein Maeo_1177 59 COG5270 COG5270, PUA domain (predicted RNA-binding domain) Translation, ribosomal structure and biogenesis 150401774 Common - putative monovalent cation/H+ antiporter subunit C Maeo_1352 39 COG1006 MnhC, Multisubunit Na+/H+ antiporter, MnhC subunit Inorganic ion transport and metabolism 150400829 Common - GDP-mannose 4,6-dehydratase Maeo_0397 232 COG1089 Gmd, GDP-D-mannose dehydratase Cell envelope biogenesis, outer membrane 150401469 Common - nickel-dependent hydrogenase large subunit Maeo_1045 104 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 150401620 Common - inosine-5'-monophosphate dehydrogenase Maeo_1197 242 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 150401665 Nonpathogen - hypothetical protein Maeo_1243 1 None None None 150400622 Common - ExsB family protein Maeo_0184 61 COG1606 COG1606, ATP-utilizing enzymes of the PP-loop superfamily General function prediction only 150401213 Common - 30S ribosomal protein S7P Maeo_0784 199 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 150401055 Nonpathogen - amino acid-binding ACT domain protein Maeo_0625 15 COG1707 COG1707, ACT domain-containing protein General function prediction only 150400790 Nonpathogen - hypothetical protein Maeo_0357 3 COG4042 COG4042, Predicted membrane protein Function unknown 150400667 Common - hypothetical protein Maeo_0229 5 None None None 150401905 Common - seryl-tRNA synthetase Maeo_1483 23 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 150401451 Nonpathogen - putative segregation and condensation protein B Maeo_1027 6 None None None 150401026 Nonpathogen - translation initiation factor IF-1A Maeo_0595 34 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 150400817 Common - glucose-1-phosphate cytidylyltransferase Maeo_0385 162 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 150401364 Common - hydrogenase, component E-formate hydrogenlyase subunit 5-like protein Maeo_0939 172 COG3261 HycE, Ni,Fe-hydrogenase III large subunit Energy production and conversion 150400653 Common - lysyl-tRNA synthetase Maeo_0215 77 COG1384 LysS, Lysyl-tRNA synthetase (class I) Translation, ribosomal structure and biogenesis 150401125 Common - transcriptional regulator, TrmB Maeo_0696 32 COG3287 COG3287, Uncharacterized conserved protein Function unknown 150401015 Common - helicase, putative Maeo_0584 6 None None None 150401152 Common - extracellular solute-binding protein family 1 Maeo_0723 49 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 150401216 Nonpathogen - 50S ribosomal protein L30e Maeo_0787 28 COG1911 RPL30, Ribosomal protein L30E Translation, ribosomal structure and biogenesis 150400658 Common - precorrin-6x reductase Maeo_0220 41 COG2099 CobK, Precorrin-6x reductase Coenzyme metabolism 150400739 Nonpathogen - Ferredoxin-thioredoxin reductase catalytic subunit-like protein Maeo_0305 15 COG4802 FtrB, Ferredoxin-thioredoxin reductase, catalytic subunit Energy production and conversion 150401424 Nonpathogen - Ribosomal protein L39e Maeo_1000 2 COG2167 RPL39, Ribosomal protein L39E Translation, ribosomal structure and biogenesis 150401812 Common - 50S ribosomal protein L29 Maeo_1390 49 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 150401819 Common rpl5p 50S ribosomal protein L5P Maeo_1397 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 150401747 Nonpathogen - chromatin protein Maeo_1325 28 COG1581 Ssh10b, Archaeal DNA-binding protein Transcription 150401208 Common - Domain of unknown function DUF1791 Maeo_0779 23 COG1416 COG1416, Uncharacterized conserved protein Function unknown 150401886 Common - Sua5/YciO/YrdC/YwlC family protein Maeo_1464 246 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 150401428 Common - arsenite-activated ATPase ArsA Maeo_1004 95 COG0003 ArsA, Predicted ATPase involved in chromosome partitioning Cell division and chromosome partitioning 150401379 Common - beta-lactamase domain protein Maeo_0955 79 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 150401437 Common - DNA topoisomerase VI subunit A Maeo_1013 34 COG1697 COG1697, DNA topoisomerase VI, subunit A DNA replication, recombination, and repair 150401411 Common - 2'-5' RNA ligase Maeo_0987 69 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 150401691 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit E Maeo_1269 14 COG4059 MtrE, Tetrahydromethanopterin S-methyltransferase, subunit E Coenzyme metabolism 150400594 Nonpathogen - Fe-S cluster domain protein Maeo_0156 13 COG2000 COG2000, Predicted Fe-S protein General function prediction only 150400670 Common - putative serine/threonine protein kinase Maeo_0232 12 COG2112 COG2112, Predicted Ser/Thr protein kinase Signal transduction mechanisms 150401405 Common - precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit Maeo_0981 93 COG2242 CobL, Precorrin-6B methylase 2 Coenzyme metabolism 150400716 Nonpathogen - DNA-directed RNA polymerase subunit E, RpoE2 Maeo_0281 26 COG2093 COG2093, DNA-directed RNA polymerase, subunit E'' Transcription 150400478 Common cbiD cobalt-precorrin-6A synthase Maeo_0040 89 COG1903 CbiD, Cobalamin biosynthesis protein CbiD Coenzyme metabolism 150401387 Nonpathogen - DsrE family protein Maeo_0963 10 COG2923 DsrF, Uncharacterized protein involved in the oxidation of intracellular sulfur Inorganic ion transport and metabolism 150400832 Common - PfkB domain protein Maeo_0400 141 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 150401006 Nonpathogen - transcriptional regulator, TrmB Maeo_0575 6 COG5625 COG5625, Predicted transcription regulator containing HTH domain Transcription 150401266 Common - Phosphoglycerate mutase Maeo_0838 70 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 150401148 Nonpathogen - hypothetical protein Maeo_0719 18 COG1356 COG1356, Uncharacterized protein conserved in archaea Function unknown 150401081 Common - putative ATPase RIL Maeo_0651 249 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 150400934 Nonpathogen - hypothetical protein Maeo_0502 1 None None None 150401042 Nonpathogen - hypothetical protein Maeo_0611 1 None None None 150401676 Nonpathogen - THUMP domain protein Maeo_1254 31 COG1258 COG1258, Predicted pseudouridylate synthase Translation, ribosomal structure and biogenesis 150400697 Nonpathogen - flagella protein Maeo_0262 8 COG3351 FlaD, Putative archaeal flagellar protein D/E Cell motility and secretion 150401062 Common - 6-pyruvoyl tetrahydropterin synthase Maeo_0632 38 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 150400682 Common - translation initiation factor IF-2 subunit gamma Maeo_0246 249 COG5257 GCD11, Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase) Translation, ribosomal structure and biogenesis 150401617 Common - GTP-binding protein HSR1-related Maeo_1194 126 COG1161 COG1161, Predicted GTPases General function prediction only 150400597 Nonpathogen - hypothetical protein Maeo_0159 6 COG4053 COG4053, Uncharacterized protein conserved in archaea Function unknown 150400956 Nonpathogen - protein of unknown function DUF95 transmembrane Maeo_0524 3 COG1300 SpoIIM, Uncharacterized membrane protein Function unknown 150400992 Common - orotate phosphoribosyltransferase Maeo_0561 200 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 150400884 Nonpathogen - hypothetical protein Maeo_0452 22 COG1786 COG1786, Uncharacterized conserved protein Function unknown 150401221 Nonpathogen rpoH DNA-directed RNA polymerase subunit H Maeo_0792 33 COG2012 RPB5, DNA-directed RNA polymerase, subunit H, RpoH/RPB5 Transcription 150401596 Nonpathogen - acetyl-CoA decarbonylase/synthase complex subunit epsilon Maeo_1173 5 COG1880 CdhB, CO dehydrogenase/acetyl-CoA synthase epsilon subunit Energy production and conversion 150400647 Nonpathogen - hypothetical protein Maeo_0209 2 None None None 150400764 Common - Rubredoxin-type Fe(Cys)4 protein Maeo_0330 106 COG1773 COG1773, Rubredoxin Energy production and conversion 150400589 Common - phosphate transporter Maeo_0151 157 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 150401891 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_1469 62 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 150401069 Common - methyltransferase small Maeo_0639 55 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 150401737 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_1315 44 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 150401722 Common - glutamine amidotransferase class-II Maeo_1300 65 COG0067 GltB, Glutamate synthase domain 1 Amino acid transport and metabolism 150401500 Nonpathogen - hypothetical protein Maeo_1077 4 None None None 150400807 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0374 189 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 150401730 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_1308 41 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 150401836 Common - Mur ligase middle domain protein Maeo_1414 20 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 150401585 Nonpathogen - protein of unknown function RIO1 Maeo_1162 34 COG0478 COG0478, RIO-like serine/threonine protein kinase fused to N-terminal HTH domain Signal transduction mechanisms 150401631 Common - glutamate-1-semialdehyde aminotransferase Maeo_1208 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 150400721 Nonpathogen - hypothetical protein Maeo_0286 5 COG4075 COG4075, Uncharacterized conserved protein, homolog of nitrogen regulatory protein PII Function unknown 150400928 Common - AIR synthase related protein Maeo_0496 123 COG2144 COG2144, Selenophosphate synthetase-related proteins General function prediction only 150400729 Common - transposase, IS605 OrfB family Maeo_0294 77 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 150400483 Common - Carbamoyl-phosphate synthase L chain ATP-binding Maeo_0045 237 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 150401789 Nonpathogen - F420-dependent methylenetetrahydromethanopterin dehydrogenase Maeo_1367 15 COG1927 Mtd, Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase Energy production and conversion 150401282 Nonpathogen - hypothetical protein Maeo_0854 2 None None None 150400617 Nonpathogen rpl37ae 50S ribosomal protein L37Ae Maeo_0179 34 COG1997 RPL43A, Ribosomal protein L37AE/L43A Translation, ribosomal structure and biogenesis 150401641 Common - thiamine pyrophosphate protein domain protein TPP-binding Maeo_1219 41 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 150401652 Nonpathogen - hypothetical protein Maeo_1230 1 None None None 150400501 Common - V-type ATP synthase subunit C Maeo_0063 33 COG1527 NtpC, Archaeal/vacuolar-type H+-ATPase subunit C Energy production and conversion 150401093 Nonpathogen - Creatininase Maeo_0663 6 COG1402 COG1402, Uncharacterized protein, putative amidase General function prediction only 150400802 Nonpathogen - (NiFe)-hydrogenase-3-type complex Eha, EhaM Maeo_0369 4 COG4084 COG4084, Uncharacterized protein conserved in archaea Function unknown 150401162 Nonpathogen - hypothetical protein Maeo_0733 28 COG1650 COG1650, Uncharacterized protein conserved in archaea Function unknown 150401609 Common - Polyprenyl synthetase Maeo_1186 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 150401184 Nonpathogen - domain of unknown function DUF1743 Maeo_0755 33 COG1571 COG1571, Predicted DNA-binding protein containing a Zn-ribbon domain General function prediction only 150401648 Nonpathogen - MCM family protein Maeo_1226 35 COG1241 MCM2, Predicted ATPase involved in replication control, Cdc46/Mcm family DNA replication, recombination, and repair 150400531 Nonpathogen - MTH865-like family protein Maeo_0093 9 COG4746 COG4746, Uncharacterized protein conserved in archaea Function unknown 150401193 Nonpathogen - hypothetical protein Maeo_0764 2 None None None 150401559 Common - undecaprenyl diphosphate synthase Maeo_1136 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 150400541 Common - phosphoribosylaminoimidazole carboxylase, catalytic subunit Maeo_0103 232 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 150401865 Common - Amidohydrolase 3 Maeo_1443 28 COG1229 FwdA, Formylmethanofuran dehydrogenase subunit A Energy production and conversion 150400937 Common - nucleoside recognition domain protein Maeo_0505 13 COG3366 COG3366, Uncharacterized protein conserved in archaea Function unknown 150401100 Common - dihydrodipicolinate reductase Maeo_0670 216 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 150401477 Common - hypothetical protein Maeo_1053 32 COG1340 COG1340, Uncharacterized archaeal coiled-coil protein Function unknown 150401510 Common - phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase Maeo_1087 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 150401705 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Maeo_1283 134 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 150401695 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit A Maeo_1273 17 COG4063 MtrA, Tetrahydromethanopterin S-methyltransferase, subunit A Coenzyme metabolism 150401709 Common - phosphodiesterase, MJ0936 family Maeo_1287 61 COG0622 COG0622, Predicted phosphoesterase General function prediction only 150401324 Common - ATPase, P-type (transporting), HAD superfamily, subfamily IC Maeo_0897 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 150401488 Common - Parallel beta-helix repeat Maeo_1064 14 None None None 150400747 Nonpathogen - hypothetical protein Maeo_0313 31 COG1439 COG1439, Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module General function prediction only 150401672 Common - Ankyrin Maeo_1250 113 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 150401764 Common - precorrin-4 C11-methyltransferase Maeo_1342 201 COG2875 CobM, Precorrin-4 methylase Coenzyme metabolism 150400843 Nonpathogen - hypothetical protein Maeo_0411 2 None None None 150401495 Common - CRISPR-associated protein, Csh2 family Maeo_1072 57 COG3649 COG3649, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 150400863 Common - glycosyl transferase group 1 Maeo_0431 226 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 150400575 Common hisG ATP phosphoribosyltransferase Maeo_0137 214 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 150400603 Common - H+-transporting two-sector ATPase, A subunit Maeo_0165 4 COG3367 COG3367, Uncharacterized conserved protein Function unknown 150401909 Nonpathogen - hypothetical protein Maeo_1487 1 None None None 150400853 Common - protein of unknown function DUF201 Maeo_0421 143 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 150401098 Nonpathogen - hypothetical protein Maeo_0668 7 COG4016 COG4016, Uncharacterized protein conserved in archaea Function unknown 150401456 Common - helix-turn-helix domain protein Maeo_1032 36 COG1813 COG1813, Predicted transcription factor, homolog of eukaryotic MBF1 Transcription 150400815 Common - hypothetical protein Maeo_0382 62 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 150401815 Common rps17p 30S ribosomal protein S17P Maeo_1393 99 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 150400550 Common - ABC transporter related Maeo_0112 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 150401549 Nonpathogen - 50S ribosomal protein L14e Maeo_1126 18 COG2163 RPL14A, Ribosomal protein L14E/L6E/L27E Translation, ribosomal structure and biogenesis 150401848 Common - Nitrogenase Maeo_1426 49 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 150401740 Common - major facilitator superfamily MFS_1 Maeo_1318 238 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 150401564 Nonpathogen - DNA polymerase II large subunit Maeo_1141 27 COG1933 COG1933, Archaeal DNA polymerase II, large subunit DNA replication, recombination, and repair 150400893 Common - S-adenosylmethionine synthetase Maeo_0461 43 COG1812 MetK, Archaeal S-adenosylmethionine synthetase Amino acid transport and metabolism 150401128 Nonpathogen - proliferating cell nuclear antigen PcnA Maeo_0699 34 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 150400848 Common - polysaccharide biosynthesis protein Maeo_0416 72 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 150401578 Nonpathogen tfb transcription initiation factor IIB Maeo_1155 34 COG1405 SUA7, Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB Transcription 150401130 Nonpathogen rpl44e 50S ribosomal protein L44e Maeo_0701 33 COG1631 RPL42A, Ribosomal protein L44E Translation, ribosomal structure and biogenesis 150400762 Common - Ferroxidase Maeo_0328 85 COG1528 Ftn, Ferritin-like protein Inorganic ion transport and metabolism 150401296 Nonpathogen - protein of unknown function DUF447 Maeo_0868 7 COG2457 COG2457, Uncharacterized conserved protein Function unknown 150401919 Nonpathogen - hypothetical protein Maeo_1497 1 None None None 150401313 Common - protein of unknown function DUF362 Maeo_0885 35 COG2006 COG2006, Uncharacterized conserved protein Function unknown 150401759 Nonpathogen - hypothetical protein Maeo_1337 9 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 150401121 Nonpathogen - hypothetical protein Maeo_0691 14 COG4008 COG4008, Predicted metal-binding transcription factor Transcription 150401539 Common - anthranilate phosphoribosyltransferase Maeo_1116 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 150401114 Common - hydrogenase expression/formation protein HypE Maeo_0684 206 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 150401807 Nonpathogen - Protein of unknown function DUF1610 Maeo_1385 30 COG2888 COG2888, Predicted Zn-ribbon RNA-binding protein with a function in translation Translation, ribosomal structure and biogenesis 150400458 Nonpathogen - helix-turn-helix domain protein Maeo_0019 29 COG1709 COG1709, Predicted transcriptional regulator Transcription 150401569 Nonpathogen - hypothetical protein Maeo_1146 2 None None None 150400825 Common - glycosyl transferase family 9 Maeo_0393 56 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 150400534 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0096 116 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 150400709 Nonpathogen - hypothetical protein Maeo_0274 1 None None None 150400625 Nonpathogen rpl12p 50S ribosomal protein L12P Maeo_0187 32 COG2058 RPP1A, Ribosomal protein L12E/L44/L45/RPP1/RPP2 Translation, ribosomal structure and biogenesis 150401751 Common - peptidylprolyl isomerase FKBP-type Maeo_1329 152 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 150401254 Nonpathogen - nucleic acid binding OB-fold tRNA/helicase-type Maeo_0825 2 COG4085 COG4085, Predicted RNA-binding protein, contains TRAM domain General function prediction only 150401029 Common - Uroporphyrinogen decarboxylase (URO-D) Maeo_0598 50 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 150401447 Common - thermosome Maeo_1023 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 150401838 Common - 3-isopropylmalate dehydrogenase Maeo_1416 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 150401929 Nonpathogen - Protein of unknown function DUF70 Maeo_1507 6 COG1822 COG1822, Predicted archaeal membrane protein Function unknown 150401678 Nonpathogen - tRNA CCA-pyrophosphorylase Maeo_1256 34 COG1746 CCA1, tRNA nucleotidyltransferase (CCA-adding enzyme) Translation, ribosomal structure and biogenesis 150401256 Common - transporter component Maeo_0827 23 None None None 150401384 Nonpathogen - 4-vinyl reductase 4VR Maeo_0960 11 COG1719 COG1719, Predicted hydrocarbon binding protein (contains V4R domain) General function prediction only 150401203 Common - succinyl-CoA synthetase subunit alpha Maeo_0774 217 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 150400751 Nonpathogen - DNA methylase Maeo_0317 32 COG2263 COG2263, Predicted RNA methylase Translation, ribosomal structure and biogenesis 150400612 Common - CTP synthetase Maeo_0174 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 150400601 Common - hypothetical protein Maeo_0163 26 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 150400758 Nonpathogen - hypothetical protein Maeo_0324 7 None None None 150401726 Common - cytidyltransferase-related domain Maeo_1304 155 COG0615 TagD, Cytidylyltransferase Cell envelope biogenesis, outer membrane / Lipid metabolism 150400774 Nonpathogen - Xylose isomerase domain protein TIM barrel Maeo_0341 8 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 150401686 Nonpathogen - Coenzyme-B sulfoethylthiotransferase Maeo_1264 14 COG4054 McrB, Methyl coenzyme M reductase, beta subunit Coenzyme metabolism 150400506 Nonpathogen - Protein of unknown function DUF22 Maeo_0068 4 COG1417 COG1417, Uncharacterized conserved protein Function unknown 150400839 Common - protein of unknown function DUF58 Maeo_0407 35 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 150400771 Nonpathogen - hypothetical protein Maeo_0338 1 None None None 150401602 Common - HAD superfamily (subfamily IA) hydrolase, TIGR02253 Maeo_1179 126 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 150400889 Common - redox-active disulfide protein 2 Maeo_0457 59 None None None 150401351 Common - 3,4-dihydroxy-2-butanone 4-phosphate synthase Maeo_0924 229 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 150401358 Common - adenine deaminase Maeo_0932 68 COG1001 AdeC, Adenine deaminase Nucleotide transport and metabolism 150401399 Nonpathogen - hypothetical protein Maeo_0975 1 None None None 150401481 Nonpathogen - hypothetical protein Maeo_1057 15 COG1590 COG1590, Uncharacterized conserved protein Function unknown 150401843 Nonpathogen - hypothetical protein Maeo_1421 1 None None None 150401397 Nonpathogen - hypothetical protein Maeo_0973 1 None None None 150400995 Common - alpha-L-glutamate ligase, RimK family Maeo_0564 112 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 150401233 Common rpl2p 50S ribosomal protein L2P Maeo_0804 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 150401012 Common - formate/nitrite transporter Maeo_0581 97 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 150401418 Common aksA trans-homoaconitate synthase Maeo_0994 214 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 150401852 Common - Nitrogenase Maeo_1430 55 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 150400521 Common - Amidohydrolase 3 Maeo_0083 27 COG1229 FwdA, Formylmethanofuran dehydrogenase subunit A Energy production and conversion 150400492 Common - glycosyl transferase group 1 Maeo_0054 221 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 150401532 Common - putative CoA-substrate-specific enzyme activase Maeo_1109 63 COG1924 COG1924, Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) Lipid metabolism 150400472 Common - adenylosuccinate synthetase Maeo_0033 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 150401131 Nonpathogen rps27e 30S ribosomal protein S27e Maeo_0702 30 COG2051 RPS27A, Ribosomal protein S27E Translation, ribosomal structure and biogenesis 150400796 Nonpathogen - hypothetical protein Maeo_0363 8 COG4036 COG4036, Predicted membrane protein Function unknown 150400619 Common - proteasome subunit alpha Maeo_0181 38 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 150401461 Nonpathogen - Protein of unknown function UPF0179 Maeo_1037 24 COG1860 COG1860, Uncharacterized protein conserved in archaea Function unknown 150400912 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0480 46 COG1146 COG1146, Ferredoxin Energy production and conversion 150401243 Nonpathogen - hypothetical protein Maeo_0814 2 None None None 150401223 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0794 93 COG2768 COG2768, Uncharacterized Fe-S center protein General function prediction only 150401292 Common - DNA ligase I, ATP-dependent Dnl1 Maeo_0864 109 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 150400636 Common - class II aldolase/adducin family protein Maeo_0198 150 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 150401271 Nonpathogen - hypothetical protein Maeo_0843 2 None None None 150401435 Nonpathogen secE preprotein translocase subunit SecE Maeo_1011 11 COG2443 Sss1, Preprotein translocase subunit Sss1 Intracellular trafficking and secretion 150401426 Common - 2-phosphosulfolactate phosphatase Maeo_1002 39 COG2045 COG2045, Phosphosulfolactate phosphohydrolase and related enzymes Coenzyme metabolism / General function prediction only 150400986 Common - Abortive infection protein Maeo_0555 12 None None None 150400695 Nonpathogen - flagellin protein Maeo_0260 9 COG1681 FlaB, Archaeal flagellins Cell motility and secretion 150401169 Nonpathogen - hypothetical protein Maeo_0740 2 None None None 150400591 Common - Phosphosulfolactate synthase Maeo_0153 22 COG1809 COG1809, Uncharacterized conserved protein Function unknown 150401654 Nonpathogen - hypothetical protein Maeo_1232 1 None None None 150401201 Common - exsB protein Maeo_0772 175 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 150401823 Nonpathogen rpl32e 50S ribosomal protein L32e Maeo_1401 34 COG1717 RPL32, Ribosomal protein L32E Translation, ribosomal structure and biogenesis 150400878 Common - hypothetical protein Maeo_0446 2 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 150401407 Common - Radical SAM domain protein Maeo_0983 30 COG2108 COG2108, Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme General function prediction only 150400710 Nonpathogen - protein of unknown function Met10 Maeo_0275 35 COG2520 COG2520, Predicted methyltransferase General function prediction only 150401034 Common - S-adenosylmethionine decarboxylase related Maeo_0603 75 COG1586 SpeD, S-adenosylmethionine decarboxylase Amino acid transport and metabolism 150401804 Common - conserved hypothetical protein 341 Maeo_1382 55 COG1808 COG1808, Predicted membrane protein Function unknown 150400481 Common - succinyl-CoA synthetase, beta subunit Maeo_0043 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 150401432 Common - Pyridoxal-dependent decarboxylase Maeo_1008 123 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 150400676 Common - lysine 2,3-aminomutase YodO family protein Maeo_0240 127 COG1509 KamA, Lysine 2,3-aminomutase Amino acid transport and metabolism 150401278 Common - Dinitrogenase iron-molybdenum cofactor biosynthesis protein Maeo_0850 13 COG1433 COG1433, Uncharacterized conserved protein Function unknown 150401116 Common - Radical SAM domain protein Maeo_0686 148 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 150400979 Nonpathogen - Domain of unkown function DUF1786 putative pyruvate format-lyase activating enzyme Maeo_0548 12 COG4012 COG4012, Uncharacterized protein conserved in archaea Function unknown 150400684 Common - precorrin-2 C20-methyltransferase Maeo_0248 130 COG2243 CobF, Precorrin-2 methylase Coenzyme metabolism 150401028 Common - cobalamin B12-binding domain protein Maeo_0597 168 COG5012 COG5012, Predicted cobalamin binding protein General function prediction only 150400904 Common - binding-protein-dependent transport systems inner membrane component Maeo_0472 71 COG4662 TupA, ABC-type tungstate transport system, periplasmic component Coenzyme metabolism 150400804 Common - NADH-ubiquinone oxidoreductase chain 49kDa Maeo_0371 194 COG3261 HycE, Ni,Fe-hydrogenase III large subunit Energy production and conversion 150401874 Common - putative ABC-2 type transport system permease protein Maeo_1452 29 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 150401366 Common - hypothetical protein Maeo_0941 32 COG4237 HyfE, Hydrogenase 4 membrane component (E) Energy production and conversion 150400669 Nonpathogen - hypothetical protein Maeo_0231 1 None None None 150400921 Nonpathogen - hypothetical protein Maeo_0489 2 None None None 150400552 Common - transport system permease protein Maeo_0114 191 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 150400679 Common - putative signal transduction protein with CBS domains Maeo_0243 162 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 150400655 Nonpathogen - phosphoesterase RecJ domain protein Maeo_0217 29 COG1107 COG1107, Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain DNA replication, recombination, and repair 150401449 Nonpathogen - H(2)-dependent methylenetetrahydromethanopterin dehydrogenase Maeo_1025 6 COG4074 Mth, H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase Energy production and conversion 150400756 Nonpathogen - MTH865-like family protein Maeo_0322 2 COG4746 COG4746, Uncharacterized protein conserved in archaea Function unknown 150400736 Common - hypothetical protein Maeo_0302 11 None None None 150401622 Common - multiple antibiotic resistance (MarC)-related protein Maeo_1199 156 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 150401739 Common - protein-L-isoaspartate O-methyltransferase Maeo_1317 167 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 150401284 Common - DsrE family protein Maeo_0856 34 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 150400727 Common - amidophosphoribosyltransferase Maeo_0292 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 150401607 Common - isopentenyl pyrophosphate isomerase Maeo_1184 86 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 150400546 Common - Magnesium chelatase Maeo_0108 81 COG1239 ChlI, Mg-chelatase subunit ChlI Coenzyme metabolism 150401742 Nonpathogen - hypothetical protein Maeo_1320 14 COG4050 COG4050, Uncharacterized protein conserved in archaea Function unknown 150401300 Common - regulatory protein ArsR Maeo_0872 168 COG0640 ArsR, Predicted transcriptional regulators Transcription 150400895 Common - pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit Maeo_0463 64 COG1144 COG1144, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit Energy production and conversion 150401095 Nonpathogen rpl40e 50S ribosomal protein L40e Maeo_0665 28 COG1552 RPL40A, Ribosomal protein L40E Translation, ribosomal structure and biogenesis 150400972 Common - Alkaline phosphatase Maeo_0541 84 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 150401523 Common rps4p 30S ribosomal protein S4 Maeo_1100 211 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 150401413 Common - hypothetical protein Maeo_0989 14 COG4997 COG4997, Uncharacterized conserved protein Function unknown 150401643 Nonpathogen - hypothetical protein Maeo_1221 1 None None None 150401917 Nonpathogen - hypothetical protein Maeo_1495 3 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 150401537 Nonpathogen - hypothetical protein Maeo_1114 1 None None None 150401348 Common - metal dependent phosphohydrolase Maeo_0921 87 COG1078 COG1078, HD superfamily phosphohydrolases General function prediction only 150400855 Common - UDP-N-acetylglucosamine 2-epimerase Maeo_0423 140 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 150401668 Nonpathogen - hypothetical protein Maeo_1246 1 None None None 150401160 Nonpathogen - hypothetical protein Maeo_0731 2 None None None 150400994 Common - protein of unknown function DUF814 Maeo_0563 55 COG1293 COG1293, Predicted RNA-binding protein homologous to eukaryotic snRNP Transcription 150401598 Common - ketol-acid reductoisomerase Maeo_1175 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 150401554 Nonpathogen - hypothetical protein Maeo_1131 4 COG1645 COG1645, Uncharacterized Zn-finger containing protein General function prediction only 150400462 Common - protein of unknown function DUF35 Maeo_0023 60 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 150401269 Nonpathogen - protein of unknown function DUF167 Maeo_0841 17 COG1872 COG1872, Uncharacterized conserved protein Function unknown 150400871 Common - putative manganese-dependent inorganic pyrophosphatase Maeo_0439 54 COG1227 PPX1, Inorganic pyrophosphatase/exopolyphosphatase Energy production and conversion 150400620 Common - cofactor-independent phosphoglycerate mutase Maeo_0182 55 COG3635 COG3635, Predicted phosphoglycerate mutase, AP superfamily Carbohydrate transport and metabolism 150401071 Nonpathogen - hypothetical protein Maeo_0641 2 None None None 150400649 Common - acetyl-CoA decarbonylase/synthase complex subunit gamma Maeo_0211 23 COG1456 CdhE, CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) Energy production and conversion 150400528 Common - cobalt transport protein CbiM Maeo_0090 71 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 150401219 Common - DNA-directed RNA polymerase subunit B' Maeo_0790 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 150401262 Common - Radical SAM domain protein Maeo_0834 51 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 150400781 Common - phosphatidylserine decarboxylase Maeo_0348 92 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 150401594 Common - bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta Maeo_1171 19 COG1614 CdhC, CO dehydrogenase/acetyl-CoA synthase beta subunit Energy production and conversion 150400687 Nonpathogen - 2-phosphoglycerate kinase Maeo_0251 14 COG2074 COG2074, 2-phosphoglycerate kinase Carbohydrate transport and metabolism 150400571 Nonpathogen - Protein of unknown function DUF371 Maeo_0133 27 COG2090 COG2090, Uncharacterized protein conserved in archaea Function unknown 150401175 Common - Tetratricopeptide TPR_2 repeat protein Maeo_0746 11 None None None 150400518 Nonpathogen rps28e 30S ribosomal protein S28e Maeo_0080 33 COG2053 RPS28A, Ribosomal protein S28E/S33 Translation, ribosomal structure and biogenesis 150401547 Common - molybdenum cofactor synthesis domain Maeo_1124 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 150401154 Common - putative HAD family hydrolase Maeo_0725 17 COG4087 COG4087, Soluble P-type ATPase General function prediction only 150400560 Common - Xylose isomerase domain protein TIM barrel Maeo_0122 38 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 150400882 Common - shikimate 5-dehydrogenase Maeo_0450 225 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 150400809 Common ksgA dimethyladenosine transferase Maeo_0376 245 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 150401141 Common - metallophosphoesterase Maeo_0712 84 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 150401784 Nonpathogen - Helix-turn-helix type 11 domain protein Maeo_1362 3 COG1654 BirA, Biotin operon repressor Transcription 150400909 Common - pyruvate/ketoisovalerate oxidoreductase, gamma subunit Maeo_0477 66 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 150401633 Nonpathogen - amino acid-binding ACT domain protein Maeo_1210 18 COG2061 COG2061, ACT-domain-containing protein, predicted allosteric regulator of homoserine dehydrogenase Amino acid transport and metabolism 150401586 Common - sugar isomerase (SIS) Maeo_1163 43 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 150401475 Common - Carbamoyltransferase Maeo_1051 52 COG2192 COG2192, Predicted carbamoyl transferase, NodU family Posttranslational modification, protein turnover, chaperones 150401013 Nonpathogen - hypothetical protein Maeo_0582 1 None None None 150401834 Common - hypothetical protein Maeo_1412 48 COG2848 COG2848, Uncharacterized conserved protein Function unknown 150400799 Common - NADH dehydrogenase (ubiquinone) Maeo_0366 42 COG0650 HyfC, Formate hydrogenlyase subunit 4 Energy production and conversion 150401497 Common - CRISPR-associated protein Cas1 Maeo_1074 102 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 150400451 Common - GTP-binding protein Maeo_0012 126 COG0218 COG0218, Predicted GTPase General function prediction only 150400803 Common - NADH ubiquinone oxidoreductase 20 kDa subunit Maeo_0370 192 COG3260 COG3260, Ni,Fe-hydrogenase III small subunit Energy production and conversion 150401517 Nonpathogen - DNA-directed RNA polymerase subunit N Maeo_1094 34 COG1644 RPB10, DNA-directed RNA polymerase, subunit N (RpoN/RPB10) Transcription 150401573 Nonpathogen - transcription initiation factor E subunit alpha Maeo_1150 32 COG1675 TFA1, Transcription initiation factor IIE, alpha subunit Transcription 150401241 Common - CrcB protein Maeo_0812 49 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 150401117 Nonpathogen - phage integrase family protein Maeo_0687 3 None None None 150400608 Common - CBS domain containing protein Maeo_0170 109 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 150401476 Common - phosphoserine phosphatase SerB Maeo_1052 167 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 150401506 Common - CRISPR-associated protein, Csm1 family Maeo_1083 25 COG1353 COG1353, Predicted hydrolase of the HD superfamily (permuted catalytic motifs) General function prediction only 150400623 Common hisH imidazole glycerol phosphate synthase subunit HisH Maeo_0185 215 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 150401754 Nonpathogen - Protein of unknown function DUF361 Maeo_1332 2 COG1991 COG1991, Uncharacterized conserved protein Function unknown 150400463 Common - hydrogenase nickel insertion protein HypA Maeo_0024 94 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 150400742 Common - CoB--CoM heterodisulfide reductase Maeo_0308 76 COG2048 HdrB, Heterodisulfide reductase, subunit B Energy production and conversion 150400930 Common - Methyltransferase type 11 Maeo_0498 100 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 150401377 Nonpathogen - hypothetical protein Maeo_0952 14 COG4065 COG4065, Uncharacterized protein conserved in archaea Function unknown 150400570 Common - 3-dehydroquinate dehydratase, type I Maeo_0132 56 COG0710 AroD, 3-dehydroquinate dehydratase Amino acid transport and metabolism 150401854 Common - nitrogen regulatory protein P-II Maeo_1432 187 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 150400474 Common - metallophosphoesterase Maeo_0035 30 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 150401133 Nonpathogen - H/ACA RNA-protein complex component Nop10p Maeo_0704 16 COG2260 COG2260, Predicted Zn-ribbon RNA-binding protein Translation, ribosomal structure and biogenesis 150401395 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0971 23 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 150400866 Common - MscS Mechanosensitive ion channel Maeo_0434 68 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 150401540 Common - anthranilate synthase component I Maeo_1117 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 150401023 Common - ribosomal RNA methyltransferase RrmJ/FtsJ Maeo_0592 138 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 150400447 Common - glycosyl transferase group 1 Maeo_0008 236 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 150401172 Common - sodium/hydrogen exchanger Maeo_0743 204 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 150400887 Nonpathogen - hypothetical protein Maeo_0455 2 None None None 150400975 Common - pyruvate kinase Maeo_0544 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 150401604 Nonpathogen - hypothetical protein Maeo_1181 8 COG4079 COG4079, Uncharacterized protein conserved in archaea Function unknown 150401354 Common - Rhodanese domain protein Maeo_0928 64 COG2603 COG2603, Predicted ATPase General function prediction only 150401656 Nonpathogen - hypothetical protein Maeo_1234 1 None None None 150400489 Common - Phosphoribosyl-AMP cyclohydrolase Maeo_0051 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 150400537 Nonpathogen - methyl-viologen-reducing hydrogenase delta subunit Maeo_0099 32 COG1908 FrhD, Coenzyme F420-reducing hydrogenase, delta subunit Energy production and conversion 150400789 Common - putative transcriptional regulator, XRE family Maeo_0356 3 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 150401534 Common - dihydroorotase, multifunctional complex type Maeo_1111 210 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 150401601 Nonpathogen - hypothetical protein Maeo_1178 5 None None None 150400820 Common - DegT/DnrJ/EryC1/StrS aminotransferase Maeo_0388 195 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 150400734 Common - molybdate ABC transporter, inner membrane subunit Maeo_0300 236 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 150401186 Nonpathogen - 30S ribosomal protein S3Ae Maeo_0757 34 COG1890 RPS1A, Ribosomal protein S3AE Translation, ribosomal structure and biogenesis 150401468 Common - coenzyme F420-reducing hydrogenase delta subunit Maeo_1044 43 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 150400931 Common - prephenate dehydratase Maeo_0499 213 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 150401771 Common - geranylgeranyl reductase Maeo_1349 65 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 150401441 Common secD preprotein translocase subunit SecD Maeo_1017 219 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 150401773 Common - hydrogenase maturation protease HycI Maeo_1351 32 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 150401577 Common - type II secretion system protein E Maeo_1154 223 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 150400494 Nonpathogen - RNA polymerase Rpb4 Maeo_0056 7 COG1460 COG1460, Uncharacterized protein conserved in archaea Function unknown 150400772 Common - phosphonopyruvate decarboxylase-related protein Maeo_0339 53 COG3635 COG3635, Predicted phosphoglycerate mutase, AP superfamily Carbohydrate transport and metabolism 150400508 Nonpathogen - hypothetical protein Maeo_0070 4 None None None 150400823 Common - polysaccharide biosynthesis protein Maeo_0391 99 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 150401258 Common - hypothetical protein Maeo_0829 9 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 150401794 Common - deoxycytidine triphosphate deaminase, putative Maeo_1372 27 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 150401778 Nonpathogen - hypothetical protein Maeo_1356 1 None None None 150400610 Common - polysaccharide biosynthesis protein Maeo_0172 12 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 150400582 Common - cobalt ABC transporter, inner membrane subunit CbiQ Maeo_0144 69 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 150400757 Common - beta-lactamase domain protein Maeo_0323 95 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 150400961 Nonpathogen - hypothetical protein Maeo_0529 1 None None None 150400795 Nonpathogen - hypothetical protein Maeo_0362 8 COG4037 COG4037, Predicted membrane protein Function unknown 150400968 Nonpathogen - hypothetical protein Maeo_0536 1 None None None 150401235 Nonpathogen rpl4lp 50S ribosomal protein L4P Maeo_0806 35 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 150401419 Nonpathogen - hypothetical protein Maeo_0995 14 COG4070 COG4070, Predicted peptidyl-prolyl cis-trans isomerase (rotamase), cyclophilin family Posttranslational modification, protein turnover, chaperones 150401644 Common - H/ACA RNA-protein complex component Cbf5p Maeo_1222 239 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 150401724 Common - glutamate synthase alpha subunit domain protein Maeo_1302 60 COG0070 GltB, Glutamate synthase domain 3 Amino acid transport and metabolism 150400700 Nonpathogen - flagellar protein G Maeo_0265 9 COG3354 FlaG, Putative archaeal flagellar protein G Cell motility and secretion 150401885 Nonpathogen - molydopterin dinucleotide-binding region Maeo_1463 17 COG1153 FwdD, Formylmethanofuran dehydrogenase subunit D Energy production and conversion 150400455 Nonpathogen - Protein of unknown function DUF63 Maeo_0016 15 COG1967 COG1967, Predicted membrane protein Function unknown 150401166 Common - ribose 5-phosphate isomerase Maeo_0737 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 150400905 Common - ABC-type tungstate transport system permease component-like protein Maeo_0473 61 COG2998 TupB, ABC-type tungstate transport system, permease component Coenzyme metabolism 150401906 Common - isopropylmalate/isohomocitrate dehydrogenase Maeo_1484 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 150400849 Common - acylneuraminate cytidylyltransferase Maeo_0417 93 COG1083 NeuA, CMP-N-acetylneuraminic acid synthetase Cell envelope biogenesis, outer membrane 150401625 Common - sodium:neurotransmitter symporter Maeo_1202 88 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 150400814 Common - dTDP-4-dehydrorhamnose reductase Maeo_0381 169 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 150401818 Nonpathogen - 30S ribosomal protein S4e Maeo_1396 34 COG1471 RPS4A, Ribosomal protein S4E Translation, ribosomal structure and biogenesis 150400914 Common - hypothetical protein Maeo_0482 26 COG1891 COG1891, Uncharacterized protein conserved in archaea Function unknown 150401035 Nonpathogen - pyruvoyl-dependent arginine decarboxylase Maeo_0604 30 COG1945 COG1945, Uncharacterized conserved protein Function unknown 150400707 Nonpathogen - Protein of unknown function DUF357 Maeo_0272 17 COG1849 COG1849, Uncharacterized protein conserved in archaea Function unknown 150400859 Common - Glutamine--scyllo-inositol transaminase Maeo_0427 196 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 150401198 Common - band 7 protein Maeo_0769 222 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 150401326 Nonpathogen - hypothetical protein Maeo_0899 2 COG1531 COG1531, Uncharacterized protein conserved in archaea Function unknown 150401861 Common - SNO glutamine amidotransferase Maeo_1439 85 COG0311 PDX2, Predicted glutamine amidotransferase involved in pyridoxine biosynthesis Coenzyme metabolism 150401487 Nonpathogen - hypothetical protein Maeo_1063 3 None None None 150401496 Common - CRISPR-associated protein, TM1802 family Maeo_1073 14 None None None 150400945 Common - molybdenum cofactor synthesis domain Maeo_0513 178 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 150401822 Common rpl6p 50S ribosomal protein L6P Maeo_1400 167 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 150401191 Common - aminotransferase class-III Maeo_0762 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 150400530 Nonpathogen - regulatory protein ArsR Maeo_0092 9 COG4742 COG4742, Predicted transcriptional regulator Transcription 150400482 Common - Carbamoyl-phosphate synthase L chain ATP-binding Maeo_0044 235 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 150401897 Nonpathogen - peptidylprolyl isomerase FKBP-type Maeo_1475 34 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 150400631 Nonpathogen - hypothetical protein Maeo_0193 2 COG3286 COG3286, Uncharacterized protein conserved in archaea Function unknown 150401381 Nonpathogen - Protein of unknown function DUF166 Maeo_0957 8 COG1810 COG1810, Uncharacterized protein conserved in archaea Function unknown 150400503 Common - V-type ATP synthase subunit A Maeo_0065 247 COG1155 NtpA, Archaeal/vacuolar-type H+-ATPase subunit A Energy production and conversion 150401743 Nonpathogen - hypothetical protein Maeo_1321 11 COG4048 COG4048, Uncharacterized protein conserved in archaea Function unknown 150400836 Nonpathogen - hypothetical protein Maeo_0404 4 None None None 150401680 Common - NADPH-dependent F420 reductase Maeo_1258 48 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 150400925 Nonpathogen - hypothetical protein Maeo_0493 28 COG1936 COG1936, Predicted nucleotide kinase (related to CMP and AMP kinases) Nucleotide transport and metabolism 150400517 Nonpathogen - Ribosomal protein L24E Maeo_0079 30 COG2075 RPL24A, Ribosomal protein L24E Translation, ribosomal structure and biogenesis 150401312 Common - anion transporter Maeo_0884 149 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 150401703 Common - pyruvate ferredoxin oxidoreductase subunit gamma Maeo_1281 70 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 150400712 Common - hypothetical protein Maeo_0277 33 COG1395 COG1395, Predicted transcriptional regulator Transcription 150400970 Nonpathogen - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0539 9 COG1146 COG1146, Ferredoxin Energy production and conversion 150401758 Common - protein of unknown function DUF214 Maeo_1336 194 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 150401180 Nonpathogen - PUA domain containing protein Maeo_0751 34 COG2016 COG2016, Predicted RNA-binding protein (contains PUA domain) Translation, ribosomal structure and biogenesis 150401463 Common - Xylose isomerase domain protein TIM barrel Maeo_1039 32 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 150401545 Common trpA tryptophan synthase subunit alpha Maeo_1122 218 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 150401716 Common - glycyl-tRNA synthetase Maeo_1294 88 COG0423 GRS1, Glycyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 150400686 Common - histidinol-phosphate aminotransferase Maeo_0250 238 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 150401588 Common - geranylgeranylglyceryl phosphate synthase-like protein Maeo_1165 27 COG1646 COG1646, Predicted phosphate-binding enzymes, TIM-barrel fold General function prediction only 150400566 Common - hypothetical protein Maeo_0128 10 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 150401682 Common - signal recognition particle protein Srp54 Maeo_1260 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 150400954 Nonpathogen - hypothetical protein Maeo_0522 8 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 150401127 Common - transcriptional regulator, LysR family Maeo_0698 192 COG0583 LysR, Transcriptional regulator Transcription 150401911 Nonpathogen - phosphatidylglycerophosphatase A Maeo_1489 14 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 150401267 Common - protein of unknown function UPF0066 Maeo_0839 61 COG1720 COG1720, Uncharacterized conserved protein Function unknown 150401593 Nonpathogen - hypothetical protein Maeo_1170 9 COG4014 COG4014, Uncharacterized protein conserved in archaea Function unknown 150400897 Common - thiamine pyrophosphate protein domain protein TPP-binding Maeo_0465 124 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 150401143 Nonpathogen - nucleic acid binding OB-fold tRNA/helicase-type Maeo_0714 3 COG5235 RFA2, Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit DNA replication, recombination, and repair 150400574 Common - alpha-L-glutamate ligase, RimK family Maeo_0136 126 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 150401058 Common - DNA-(apurinic or apyrimidinic site) lyase Maeo_0628 238 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 150400549 Common - periplasmic binding protein Maeo_0111 21 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 150400784 Common - small GTP-binding protein Maeo_0351 82 COG0486 ThdF, Predicted GTPase General function prediction only 150400923 Nonpathogen - Chromatin associated protein KTI12 Maeo_0491 3 COG4088 COG4088, Predicted nucleotide kinase Nucleotide transport and metabolism 150401832 Nonpathogen - tRNA 2'-O-methylase Maeo_1410 31 COG1303 COG1303, Uncharacterized protein conserved in archaea Function unknown 150401733 Nonpathogen - protein of unknown function DUF211 Maeo_1311 23 COG1888 COG1888, Uncharacterized protein conserved in archaea Function unknown 150400880 Common - protein of unknown function DUF201 Maeo_0448 18 COG1821 COG1821, Predicted ATP-utilizing enzyme (ATP-grasp superfamily) General function prediction only 150401711 Nonpathogen - hypothetical protein Maeo_1289 11 COG4800 COG4800, Predicted transcriptional regulator with an HTH domain Transcription 150401849 Common - Nitrogenase Maeo_1427 53 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 150400998 Common - D-3-phosphoglycerate dehydrogenase Maeo_0567 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 150401914 Nonpathogen - flap endonuclease-1 Maeo_1492 34 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 150400681 Common sdhA succinate dehydrogenase flavoprotein subunit Maeo_0245 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 150400746 Common - Radical SAM domain protein Maeo_0312 51 COG2100 COG2100, Predicted Fe-S oxidoreductase General function prediction only 150401368 Common - NADH dehydrogenase (quinone) Maeo_0943 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 150401273 Common - LOR/SDH bifunctional protein conserved domain protein Maeo_0845 33 COG1915 COG1915, Uncharacterized conserved protein Function unknown 150401630 Nonpathogen - hypothetical protein Maeo_1207 2 None None None 150400613 Nonpathogen - prefoldin, beta subunit Maeo_0175 23 COG1382 GimC, Prefoldin, chaperonin cofactor Posttranslational modification, protein turnover, chaperones 150400854 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Maeo_0422 78 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 150401528 Common - sulphate transporter Maeo_1105 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 150401285 Common - protein of unknown function Met10 Maeo_0857 144 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 150401531 Common - protein of unknown function DUF124 Maeo_1108 76 COG2013 COG2013, Uncharacterized conserved protein Function unknown 150401260 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0832 80 COG0348 NapH, Polyferredoxin Energy production and conversion 150401466 Common - coenzyme F420-reducing hydrogenase subunit beta Maeo_1042 40 COG1035 FrhB, Coenzyme F420-reducing hydrogenase, beta subunit Energy production and conversion 150400876 Nonpathogen - Aldehyde ferredoxin oxidoreductase Maeo_0444 20 COG2414 COG2414, Aldehyde:ferredoxin oxidoreductase Energy production and conversion 150400777 Common - dTMP kinase Maeo_0344 181 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 150401455 Common - aspartate/glutamate/uridylate kinase Maeo_1031 39 COG1608 COG1608, Predicted archaeal kinase General function prediction only 150401808 Nonpathogen ef1B elongation factor 1-beta Maeo_1386 3 COG2092 EFB1, Translation elongation factor EF-1beta Translation, ribosomal structure and biogenesis 150400816 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Maeo_0383 168 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 150401189 Nonpathogen - Pre-mRNA processing ribonucleoprotein, binding region Maeo_0760 34 COG1498 SIK1, Protein implicated in ribosomal biogenesis, Nop56p homolog Translation, ribosomal structure and biogenesis 150400725 Nonpathogen - Like-Sm ribonucleoprotein core Maeo_0290 31 COG1958 LSM1, Small nuclear ribonucleoprotein (snRNP) homolog Transcription 150401075 Nonpathogen - hypothetical protein Maeo_0645 2 None None None 150401287 Nonpathogen - N-glycosylase/DNA lyase Maeo_0859 11 COG4047 COG4047, Uncharacterized protein conserved in archaea Function unknown 150400585 Common - protein of unknown function DUF752 Maeo_0147 24 COG4121 COG4121, Uncharacterized conserved protein Function unknown 162329870 Common - bifunctional formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase Maeo_0614 59 COG0269 SgbH, 3-hexulose-6-phosphate synthase and related proteins Carbohydrate transport and metabolism 150401688 Nonpathogen - Methyl-coenzyme M reductase operon protein C Maeo_1266 14 COG4056 McrC, Methyl coenzyme M reductase, subunit C Coenzyme metabolism 150400664 Nonpathogen - protein of unknown function DUF75 Maeo_0226 31 COG2047 COG2047, Uncharacterized protein (ATP-grasp superfamily) General function prediction only 150401108 Common - phosphoribosylformylglycinamidine synthase subunit I Maeo_0678 232 COG0047 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain Nucleotide transport and metabolism 150400514 Nonpathogen - protein of unknown function DUF75 Maeo_0076 32 COG1938 COG1938, Archaeal enzymes of ATP-grasp superfamily General function prediction only 150401696 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit A Maeo_1274 17 COG4063 MtrA, Tetrahydromethanopterin S-methyltransferase, subunit A Coenzyme metabolism 150400487 Common - beta-lactamase domain protein Maeo_0049 155 COG1782 COG1782, Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain General function prediction only 150401417 Nonpathogen - hypothetical protein Maeo_0993 2 None None None 150400770 Common - heavy metal translocating P-type ATPase Maeo_0336 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 150400797 Nonpathogen - putative transmembrane subunit of a hydrogenase Maeo_0364 11 COG4078 COG4078, Predicted membrane protein Function unknown 150400657 Nonpathogen - hypothetical protein Maeo_0219 1 None None None 150400915 Common - sodium/hydrogen exchanger Maeo_0483 119 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 150401301 Common - molybdopterin-guanine dinucleotide biosynthesis protein B Maeo_0873 73 COG1763 MobB, Molybdopterin-guanine dinucleotide biosynthesis protein Coenzyme metabolism 150401224 Common - PP-loop domain protein Maeo_0795 144 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 150401712 Nonpathogen - Protein of unknown function DUF1188 Maeo_1290 7 COG4017 COG4017, Uncharacterized protein conserved in archaea Function unknown 150401157 Nonpathogen - transcriptional regulator, TrmB Maeo_0728 11 COG3355 COG3355, Predicted transcriptional regulator Transcription 150401067 Nonpathogen - hypothetical protein Maeo_0637 10 COG1255 COG1255, Uncharacterized protein conserved in archaea Function unknown 150401051 Common alaS alanyl-tRNA synthetase Maeo_0621 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150401556 Common - protein of unknown function DUF87 Maeo_1133 93 COG0433 COG0433, Predicted ATPase General function prediction only 150401900 Nonpathogen - hypothetical protein Maeo_1478 1 None None None 150401088 Common - protein of unknown function DUF121 Maeo_0658 25 COG1920 COG1920, Uncharacterized conserved protein Function unknown 150401167 Common - imidazoleglycerol phosphate synthase, cyclase subunit Maeo_0738 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 150401011 Nonpathogen - hypothetical protein Maeo_0580 3 None None None 150401120 Common - aldolase Maeo_0690 86 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 150401333 Nonpathogen - hypothetical protein Maeo_0906 1 None None None 150401491 Nonpathogen - hypothetical protein Maeo_1067 3 None None None 150401786 Nonpathogen - prefoldin, alpha subunit Maeo_1364 13 COG1730 GIM5, Predicted prefoldin, molecular chaperone implicated in de novo protein folding Posttranslational modification, protein turnover, chaperones 150401472 Common - chlorohydrolase Maeo_1048 84 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 150401659 Nonpathogen - hypothetical protein Maeo_1237 1 None None None 150401295 Nonpathogen - hypothetical protein Maeo_0867 1 None None None 150401430 Common - pyruvate carboxylase subunit A Maeo_1006 235 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 150401521 Nonpathogen - RNA polymerase insert Maeo_1098 34 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 150401871 Common - DNA topoisomerase type IA zn finger domain protein Maeo_1449 3 COG0551 TopA, Zn-finger domain associated with topoisomerase type I DNA replication, recombination, and repair 150400674 Nonpathogen - hypothetical protein Maeo_0238 1 None None None 150400693 Nonpathogen - flagellin protein Maeo_0258 9 COG1681 FlaB, Archaeal flagellins Cell motility and secretion 150400644 Common - F420-0--gamma-glutamyl ligase Maeo_0206 44 COG1478 COG1478, Uncharacterized conserved protein Function unknown 150401119 Common - chorismate synthase Maeo_0689 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 150400542 Common - thiamine biosynthesis protein ThiC Maeo_0104 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 150401210 Common rps10p 30S ribosomal protein S10P Maeo_0781 242 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 150401433 Common - ribosomal protein L11 Maeo_1009 244 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 150400480 Common - aspartate carbamoyltransferase regulatory subunit Maeo_0042 64 COG1781 PyrI, Aspartate carbamoyltransferase, regulatory subunit Nucleotide transport and metabolism 150401003 Common - phosphate ABC transporter, ATPase subunit Maeo_0572 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 150401610 Common - sulfopyruvate decarboxylase subunit alpha Maeo_1187 35 COG4032 COG4032, Predicted thiamine-pyrophosphate-binding protein General function prediction only 150401401 Common - putative transcriptional regulator, CopG family Maeo_0977 37 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 150401021 Common - hypothetical protein Maeo_0590 22 COG4895 COG4895, Uncharacterized conserved protein Function unknown 150400569 Common - DEAD/DEAH box helicase domain protein Maeo_0131 44 COG1111 MPH1, ERCC4-like helicases DNA replication, recombination, and repair 150400523 Common - molybdopterin oxidoreductase Maeo_0085 156 COG1029 FwdB, Formylmethanofuran dehydrogenase subunit B Energy production and conversion 150401045 Common - hypothetical protein Maeo_0615 41 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 150401840 Nonpathogen - hypothetical protein Maeo_1418 1 None None None 150401204 Common - mevalonate kinase Maeo_0775 41 COG1577 ERG12, Mevalonate kinase Lipid metabolism 150401766 Common - phosphoesterase RecJ domain protein Maeo_1344 29 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 150401078 Nonpathogen - hypothetical protein Maeo_0648 2 COG1991 COG1991, Uncharacterized conserved protein Function unknown 150401866 Nonpathogen - zinc finger protein Maeo_1444 3 None None None 150400977 Common - quinolinate synthetase Maeo_0546 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 150401646 Common - nitrogenase reductase-like protein Maeo_1224 106 COG1348 NifH, Nitrogenase subunit NifH (ATPase) Inorganic ion transport and metabolism 150401265 Common - non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family Maeo_0837 209 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 150400519 Common rpl7ae 50S ribosomal protein L7Ae Maeo_0081 39 COG1358 RPL8A, Ribosomal protein HS6-type (S12/L30/L7a) Translation, ribosomal structure and biogenesis 150400980 Common - glycosyl transferase family 2 Maeo_0549 144 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 150401606 Nonpathogen - transcriptional regulator, LysR family Maeo_1183 7 COG0583 LysR, Transcriptional regulator Transcription 150401895 Common - putative deoxyhypusine synthase Maeo_1473 58 COG1899 DYS1, Deoxyhypusine synthase Posttranslational modification, protein turnover, chaperones 150400821 Common - NAD-dependent epimerase/dehydratase Maeo_0389 232 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 150401232 Common rps19p 30S ribosomal protein S19P Maeo_0803 212 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 150400496 Nonpathogen - Protein of unknown function DUF531 Maeo_0058 9 COG1772 COG1772, Uncharacterized protein conserved in archaea Function unknown 150400755 Common - NADPH-dependent FMN reductase Maeo_0321 51 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 150401799 Common pheT phenylalanyl-tRNA synthetase subunit beta Maeo_1377 204 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 150400852 Common - N-acetylneuraminate synthase Maeo_0420 78 COG2089 SpsE, Sialic acid synthase Cell envelope biogenesis, outer membrane 150400917 Common - UDP-N-acetylglucosamine 2-epimerase Maeo_0485 154 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 150401443 Nonpathogen - hypothetical protein Maeo_1019 5 COG4077 COG4077, Uncharacterized protein conserved in archaea Function unknown 150401251 Nonpathogen - hypothetical protein Maeo_0822 2 COG2512 COG2512, Uncharacterized membrane-associated protein/domain Function unknown 150401329 Common - putative adenylyl cyclase CyaB Maeo_0902 33 COG1437 CyaB, Adenylate cyclase, class 2 (thermophilic) Nucleotide transport and metabolism 150400580 Common - protein of unknown function DUF43 Maeo_0142 18 COG1568 COG1568, Predicted methyltransferases General function prediction only 150401237 Nonpathogen - Translin Maeo_0808 20 COG2178 COG2178, Predicted RNA-binding protein of the translin family Translation, ribosomal structure and biogenesis 150401318 Common - hypothetical protein Maeo_0891 14 COG4902 COG4902, Uncharacterized protein conserved in archaea Function unknown 150400787 Common - ornithine carbamoyltransferase Maeo_0354 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 150401904 Common - ammonium transporter Maeo_1482 203 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 150401792 Common - glutamyl-tRNA(Gln) amidotransferase subunit D Maeo_1370 139 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 150401776 Nonpathogen - hypothetical protein Maeo_1354 2 None None None 150401571 Common - protein of unknown function DUF198 Maeo_1148 59 COG1469 COG1469, Uncharacterized conserved protein Function unknown 150400634 Common - CoA-binding domain protein Maeo_0196 143 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 150401178 Common - methylenetetrahydromethanopterin reductase Maeo_0749 48 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 150400999 Nonpathogen - protein of unknown function DUF6 transmembrane Maeo_0568 2 COG2510 COG2510, Predicted membrane protein Function unknown 150400497 Nonpathogen - ATPase A1A0 subunit H Maeo_0059 1 None None None 150401714 Common pheS phenylalanyl-tRNA synthetase subunit alpha Maeo_1292 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 150401525 Common argS arginyl-tRNA synthetase Maeo_1102 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150400525 Common - AIR synthase related protein domain protein Maeo_0087 13 COG2144 COG2144, Selenophosphate synthetase-related proteins General function prediction only 150400982 Nonpathogen - hypothetical protein Maeo_0551 2 None None None 150401887 Common - transferase hexapeptide repeat containing protein Maeo_1465 122 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 150400733 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Maeo_0299 108 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 150401393 Nonpathogen - hypothetical protein Maeo_0969 4 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 150401228 Common - ribosomal-protein-alanine acetyltransferase Maeo_0799 62 COG0456 RimI, Acetyltransferases General function prediction only 150400440 Nonpathogen - Protein of unknown function DUF70 Maeo_0001 2 COG1822 COG1822, Predicted archaeal membrane protein Function unknown 150400778 Nonpathogen - replication factor A Maeo_0345 28 COG1599 RFA1, Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins DNA replication, recombination, and repair 150401614 Nonpathogen - putative monovalent cation/H+ antiporter subunit G Maeo_1191 5 COG1320 MnhG, Multisubunit Na+/H+ antiporter, MnhG subunit Inorganic ion transport and metabolism 150400615 Nonpathogen - ribosomal biogenesis protein Maeo_0177 8 COG2136 IMP4, Predicted exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component, contains IMP4 domain Translation, ribosomal structure and biogenesis / RNA processing and modification 150400476 Common - ExsB family protein Maeo_0037 9 COG1365 COG1365, Predicted ATPase (PP-loop superfamily) General function prediction only 150400639 Nonpathogen - hypothetical protein Maeo_0201 1 None None None 150400857 Common - LmbE family protein Maeo_0425 42 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 150400628 Nonpathogen - RNA polymerase dimerisation Maeo_0190 2 COG1761 RPB11, DNA-directed RNA polymerase, subunit L Transcription 150401320 Common - putative cell wall binding repeat 2-containing protein Maeo_0893 6 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 150401319 Common - putative cell wall binding repeat 2-containing protein Maeo_0892 4 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 150401334 Nonpathogen gatC aspartyl/glutamyl-tRNA amidotransferase subunit C Maeo_0907 4 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 150401844 Common - ABC transporter related Maeo_1422 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 150401196 Nonpathogen - hypothetical protein Maeo_0767 2 None None None 150400641 Nonpathogen - PRC-barrel domain protein Maeo_0203 2 COG1873 COG1873, Uncharacterized conserved protein Function unknown 150401248 Common - LPPG domain containing protein Maeo_0819 42 COG0391 COG0391, Uncharacterized conserved protein Function unknown 150401868 Common - putative agmatinase Maeo_1446 147 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 150401106 Common - aspartate kinase Maeo_0676 236 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 150400698 Nonpathogen - flagella protein Maeo_0263 7 COG3351 FlaD, Putative archaeal flagellar protein D/E Cell motility and secretion 150401582 Nonpathogen - hypothetical protein Maeo_1159 2 None None None 150401526 Nonpathogen - hypothetical protein Maeo_1103 12 COG4066 COG4066, Uncharacterized protein conserved in archaea Function unknown 150400715 Common - DNA-directed RNA polymerase subunit E' Maeo_0280 77 COG1095 RPB7, DNA-directed RNA polymerase, subunit E' Transcription 150400505 Common - V-type ATP synthase subunit D Maeo_0067 44 COG1394 NtpD, Archaeal/vacuolar-type H+-ATPase subunit D Energy production and conversion 150400830 Common - ADP-L-glycero-D-manno-heptose-6-epimerase Maeo_0398 231 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 150401701 Common - hydrolase, TatD family Maeo_1279 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 150401328 Common - translation initiation factor IF-2 Maeo_0901 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 150401474 Common - hypothetical protein Maeo_1050 16 None None None 150400860 Common - polysaccharide biosynthesis protein CapD Maeo_0428 215 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 150401783 Common - replication factor C large subunit Maeo_1361 187 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 150401458 Nonpathogen - hypothetical protein Maeo_1034 7 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 150401501 Nonpathogen - hypothetical protein Maeo_1078 6 None None None 150400621 Common - biotin synthase Maeo_0183 178 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 150401110 Common - dihydroxy-acid dehydratase Maeo_0680 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 150401515 Common - enolase Maeo_1092 76 COG0148 Eno, Enolase Carbohydrate transport and metabolism 150401031 Common - Uroporphyrinogen decarboxylase (URO-D) Maeo_0600 21 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 150400868 Nonpathogen - protein of unknown function UPF0132 Maeo_0436 9 COG4818 COG4818, Predicted membrane protein Function unknown 150401560 Nonpathogen - methlytransferase Maeo_1137 14 COG4002 COG4002, Predicted phosphotransacetylase General function prediction only 150401275 Nonpathogen - PRC-barrel domain protein Maeo_0847 2 COG1873 COG1873, Uncharacterized conserved protein Function unknown 150400453 Common - UbiD family decarboxylase Maeo_0014 153 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 150400782 Nonpathogen - hypothetical protein Maeo_0349 4 COG1365 COG1365, Predicted ATPase (PP-loop superfamily) General function prediction only 150401153 Common - selenophosphate synthetase Maeo_0724 154 COG0709 SelD, Selenophosphate synthase Amino acid transport and metabolism 150401856 Common - nitrogenase iron protein Maeo_1434 70 COG1348 NifH, Nitrogenase subunit NifH (ATPase) Inorganic ion transport and metabolism 150400555 Nonpathogen - cellulosome anchoring protein cohesin region Maeo_0117 1 None None None 150401375 Nonpathogen - hypothetical protein Maeo_0950 19 COG1458 COG1458, Predicted DNA-binding protein containing PIN domain General function prediction only 150401307 Nonpathogen - hypothetical protein Maeo_0879 2 None None None 150400646 Common - Pyrrolo-quinoline quinone Maeo_0208 49 COG1520 COG1520, FOG: WD40-like repeat Function unknown 150401627 Nonpathogen - hypothetical protein Maeo_1204 14 COG4052 COG4052, Uncharacterized protein related to methyl coenzyme M reductase subunit C General function prediction only 150400899 Common - carbamoyl-phosphate synthase, large subunit Maeo_0467 236 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 150400952 Nonpathogen - hypothetical protein Maeo_0520 1 None None None 150401683 Common - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Maeo_1261 152 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 150401440 Common - preprotein translocase subunit SecF Maeo_1016 162 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 150401280 Nonpathogen - hypothetical protein Maeo_0852 2 None None None 150400459 Common - hypothetical protein Maeo_0020 211 COG3425 PksG, 3-hydroxy-3-methylglutaryl CoA synthase Lipid metabolism 150401091 Nonpathogen - hypothetical protein Maeo_0661 9 COG1658 COG1658, Small primase-like proteins (Toprim domain) DNA replication, recombination, and repair 150400943 Common - binding-protein-dependent transport systems inner membrane component Maeo_0511 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 150401925 Common - Transketolase domain protein Maeo_1503 223 COG3959 COG3959, Transketolase, N-terminal subunit Carbohydrate transport and metabolism 150401194 Nonpathogen - Protein of unknown function DUF137 Maeo_0765 30 COG1701 COG1701, Uncharacterized protein conserved in archaea Function unknown 150401083 Common - DNA polymerase Pol2 Maeo_0653 63 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 150400723 Nonpathogen - hypothetical protein Maeo_0288 1 None None None 150400959 Nonpathogen - protein of unknown function DUF95 transmembrane Maeo_0527 6 COG1300 SpoIIM, Uncharacterized membrane protein Function unknown 150401073 Common - phosphoesterase RecJ domain protein Maeo_0643 51 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 150400536 Common - NADH ubiquinone oxidoreductase 20 kDa subunit Maeo_0098 60 COG1941 FrhG, Coenzyme F420-reducing hydrogenase, gamma subunit Energy production and conversion 150400583 Common - cobalt transport protein CbiN Maeo_0145 20 COG1930 CbiN, ABC-type cobalt transport system, periplasmic component Inorganic ion transport and metabolism 150400666 Common - protein of unknown function DUF262 Maeo_0228 52 COG3472 COG3472, Uncharacterized conserved protein Function unknown 150401047 Nonpathogen - Resolvase, Holliday junction-type Maeo_0617 15 COG1591 COG1591, Holliday junction resolvase - archaeal type DNA replication, recombination, and repair 150401892 Common - hypothetical protein Maeo_1470 26 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 150400769 Common - ABC transporter related Maeo_0335 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 150401518 Nonpathogen rps9p 30S ribosomal protein S9P Maeo_1095 34 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 150401720 Common - regulatory protein ArsR Maeo_1298 29 COG1510 COG1510, Predicted transcriptional regulators Transcription 150401781 Common - NADH ubiquinone oxidoreductase 20 kDa subunit Maeo_1359 192 COG3260 COG3260, Ni,Fe-hydrogenase III small subunit Energy production and conversion 150401830 Common - glycosyl transferase family 4 Maeo_1408 101 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 150401136 Common - protein of unknown function UPF0153 Maeo_0707 24 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 150400688 Common - UspA domain protein Maeo_0252 178 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 150400564 Nonpathogen - 50S ribosomal protein L31e Maeo_0126 32 COG2097 RPL31A, Ribosomal protein L31E Translation, ribosomal structure and biogenesis 150401735 Nonpathogen - vanadium nitrogenase-associated related protein N Maeo_1313 15 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 150401164 Common - ferrous iron transport protein B Maeo_0735 183 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 150401543 Common - tryptophan synthase subunit beta Maeo_1120 226 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 150400547 Common cobN cobaltochelatase Maeo_0109 89 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 150401145 Common - Na+/Ca+ antiporter, CaCA family Maeo_0716 120 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 150401150 Common - permease Maeo_0721 105 COG0701 COG0701, Predicted permeases General function prediction only 150400466 Common - putative translation initiation factor, aIF-2BI family Maeo_0027 131 COG0182 COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 150401591 Common - argininosuccinate lyase Maeo_1168 240 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 150400606 Common ribH riboflavin synthase subunit beta Maeo_0168 185 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 150400540 Common - Nucleoside-diphosphate kinase Maeo_0102 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 150400441 Nonpathogen - Protein of unknown function DUF373 Maeo_0002 29 COG2237 COG2237, Predicted membrane protein Function unknown 150401360 Nonpathogen - cysteine-rich small domain Maeo_0934 15 COG2158 COG2158, Uncharacterized protein containing a Zn-finger-like domain General function prediction only 150401064 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0634 165 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 150401693 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit C Maeo_1271 14 COG4061 MtrC, Tetrahydromethanopterin S-methyltransferase, subunit C Coenzyme metabolism 150401493 Common - CRISPR-associated helicase Cas3 Maeo_1070 71 COG1203 COG1203, Predicted helicases General function prediction only 150401341 Common - nicotinate-nucleotide pyrophosphorylase Maeo_0914 204 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 150401182 Common - protein of unknown function DUF34 Maeo_0753 138 COG0327 COG0327, Uncharacterized conserved protein Function unknown 150401912 Common - hypothetical protein Maeo_1490 5 COG2983 COG2983, Uncharacterized conserved protein Function unknown 150401846 Common - binding-protein-dependent transport systems inner membrane component Maeo_1424 210 COG0555 CysU, ABC-type sulfate transport system, permease component Posttranslational modification, protein turnover, chaperones 150401331 Common - putative molybdenum cofactor biosynthesis protein C Maeo_0904 196 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 150401863 Common - 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase Maeo_1441 65 COG1691 COG1691, NCAIR mutase (PurE)-related proteins General function prediction only 150401373 Common - hypothetical protein Maeo_0948 24 COG2361 COG2361, Uncharacterized conserved protein Function unknown 150401827 Nonpathogen rpl30p 50S ribosomal protein L30P Maeo_1405 34 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 150400567 Common - protein of unknown function DUF101 Maeo_0129 39 COG1371 COG1371, Uncharacterized conserved protein Function unknown 150401661 Nonpathogen - hypothetical protein Maeo_1239 1 None None None 150401923 Nonpathogen - translation initiation factor IF-2 subunit beta Maeo_1501 34 COG1601 GCD7, Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain Translation, ribosomal structure and biogenesis 150401018 Common - hypothetical protein Maeo_0587 42 COG3830 COG3830, ACT domain-containing protein Signal transduction mechanisms 150401389 Nonpathogen - DsrH family protein Maeo_0965 1 COG2168 DsrH, Uncharacterized conserved protein involved in oxidation of intracellular sulfur Inorganic ion transport and metabolism 150400890 Nonpathogen - protein of unknown function DUF115 Maeo_0458 29 COG1634 COG1634, Uncharacterized Rossmann fold enzyme General function prediction only 150401873 Common - ABC transporter related protein Maeo_1451 249 COG4152 COG4152, ABC-type uncharacterized transport system, ATPase component General function prediction only 150401176 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Maeo_0747 247 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 150401636 Nonpathogen - methyl-viologen-reducing hydrogenase delta subunit Maeo_1213 31 COG1908 FrhD, Coenzyme F420-reducing hydrogenase, delta subunit Energy production and conversion 150401470 Common glyA serine hydroxymethyltransferase Maeo_1046 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 150401839 Common - phosphoribosylformylglycinamidine synthase subunit PurS Maeo_1417 106 COG1828 PurS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component Nucleotide transport and metabolism 150400691 Nonpathogen - flagellin protein Maeo_0256 9 COG1681 FlaB, Archaeal flagellins Cell motility and secretion 150401508 Nonpathogen - hypothetical protein Maeo_1085 1 None None None 150401001 Common - phosphate ABC transporter, inner membrane subunit PstC Maeo_0570 223 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 150401054 Nonpathogen - N(2),N(2)-dimethylguanosine tRNA methyltransferase Maeo_0624 38 COG1867 TRM1, N2,N2-dimethylguanosine tRNA methyltransferase Translation, ribosomal structure and biogenesis 150401041 Common - malate dehydrogenase Maeo_0610 176 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 150401040 Common - Phosphopyruvate hydratase Maeo_0609 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 150400559 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0121 15 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 150400800 Nonpathogen - hypothetical protein Maeo_0367 1 None None None 150400886 Common - ABC-3 protein Maeo_0454 163 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 150400703 Nonpathogen - flagellar assembly protein J Maeo_0268 18 COG1955 FlaJ, Archaeal flagella assembly protein J Cell motility and secretion / Intracellular trafficking and secretion 150401806 Common - aspartate/glutamate/uridylate kinase Maeo_1384 20 COG2054 COG2054, Uncharacterized archaeal kinase related to aspartokinases, uridylate kinases General function prediction only 150400819 Common - CDP-glucose 4,6-dehydratase Maeo_0387 219 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 150400673 Common - Tetratricopeptide TPR_2 repeat protein Maeo_0235 86 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 150401658 Nonpathogen - hypothetical protein Maeo_1236 1 None None None 150401761 Common pyrB aspartate carbamoyltransferase catalytic subunit Maeo_1339 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 150401768 Common - 2-hydroxyglutaryl-CoA dehydratase D-component Maeo_1346 38 COG1775 HgdB, Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB Amino acid transport and metabolism 150401403 Common - helicase domain protein Maeo_0979 118 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 150401800 Common - conserved hypothetical protein 245 Maeo_1378 70 COG0390 COG0390, ABC-type uncharacterized transport system, permease component General function prediction only 150401206 Common - coenzyme F420-reducing hydrogenase delta subunit Maeo_0777 67 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 150401858 Common - response regulator receiver protein Maeo_1436 220 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 150401290 Nonpathogen - Protein of unknown function DUF509 Maeo_0862 2 COG1617 COG1617, Uncharacterized conserved protein Function unknown 150401612 Common - threonyl-tRNA synthetase Maeo_1189 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150401718 Nonpathogen - hypothetical protein Maeo_1296 18 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 150400964 Nonpathogen - protein of unknown function DUF95 transmembrane Maeo_0532 13 COG1300 SpoIIM, Uncharacterized membrane protein Function unknown 150401289 Common - uroporphyrin-III C-methyltransferase Maeo_0861 204 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 150401303 Nonpathogen - hypothetical protein Maeo_0875 1 None None None 150401745 Common - Alanine--glyoxylate transaminase Maeo_1323 165 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 150401086 Nonpathogen - ATP dependent DNA ligase Maeo_0656 19 COG1423 COG1423, ATP-dependent DNA ligase, homolog of eukaryotic ligase III DNA replication, recombination, and repair 150400958 Nonpathogen - hypothetical protein Maeo_0526 1 None None None 150401159 Common - intracellular protease, PfpI family Maeo_0730 124 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 150401218 Common - DNA-directed RNA polymerase subunit alpha Maeo_0789 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 150400659 Common - protein of unknown function DUF88 Maeo_0221 24 COG1432 COG1432, Uncharacterized conserved protein Function unknown 150400792 Nonpathogen - hypothetical protein Maeo_0359 5 COG4040 COG4040, Predicted membrane protein Function unknown 150400901 Common - Carbonic anhydrase/acetyltransferase isoleucine patch superfamily-like protein Maeo_0469 146 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 150401065 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0635 11 COG1148 HdrA, Heterodisulfide reductase, subunit A and related polyferredoxins Energy production and conversion 150400650 Nonpathogen - Protein of unknown function DUF166 Maeo_0212 10 COG1810 COG1810, Uncharacterized protein conserved in archaea Function unknown 150401356 Common - TPR repeat-containing protein Maeo_0930 154 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 150400908 Nonpathogen - 4Fe-4S ferredoxin iron-sulfur binding domain protein Maeo_0476 4 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 150401211 Common - elongation factor 1-alpha Maeo_0782 249 COG5256 TEF1, Translation elongation factor EF-1alpha (GTPase) Translation, ribosomal structure and biogenesis