Methanococcus vannielii SB, complete genome NC_009634 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 150399606 Nonpathogen - Translin Mevan_0856 23 COG2178 COG2178, Predicted RNA-binding protein of the translin family Translation, ribosomal structure and biogenesis 150399121 Common - V-type ATP synthase subunit A Mevan_0367 247 COG1155 NtpA, Archaeal/vacuolar-type H+-ATPase subunit A Energy production and conversion 150400273 Nonpathogen - hypothetical protein Mevan_1535 1 None None None 150398895 Nonpathogen - hypothetical protein Mevan_0139 1 None None None 150399392 Common - hydrogenase assembly chaperone hypC/hupF Mevan_0641 83 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 150400369 Nonpathogen - hypothetical protein Mevan_1632 1 None None None 150400129 Nonpathogen - amino acid-binding ACT domain protein Mevan_1387 15 COG1707 COG1707, ACT domain-containing protein General function prediction only 150399061 Common - acetyl-CoA decarbonylase/synthase complex subunit delta Mevan_0307 20 COG2069 CdhD, CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein) Energy production and conversion 150399451 Common - permease Mevan_0700 76 COG0701 COG0701, Predicted permeases General function prediction only 150399191 Common - Ribulose-phosphate 3-epimerase Mevan_0439 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 150399007 Common - shikimate 5-dehydrogenase Mevan_0253 223 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 150399825 Common - ammonium transporter Mevan_1080 202 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 150399712 Nonpathogen - protein of unknown function DUF129 Mevan_0964 8 COG4071 COG4071, Uncharacterized protein conserved in archaea Function unknown 150399072 Common - hypothetical protein Mevan_0318 13 None None None 150399762 Common - transcriptional regulator, LysR family Mevan_1014 181 COG0583 LysR, Transcriptional regulator Transcription 150399888 Common - coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein Mevan_1144 34 COG1035 FrhB, Coenzyme F420-reducing hydrogenase, beta subunit Energy production and conversion 150400280 Common - acetolactate synthase catalytic subunit Mevan_1543 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 150399015 Nonpathogen - putative integrase/recombinase Mevan_0261 1 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 150400264 Common - Na/Pi-cotransporter II-related protein Mevan_1525 135 COG1283 NptA, Na+/phosphate symporter Inorganic ion transport and metabolism 150400186 Common - putative molybdopterin-guanine dinucleotide biosynthesis protein A Mevan_1447 63 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 150399616 Common - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Mevan_0866 153 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 150398876 Common - hypothetical protein Mevan_0119 3 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 150399719 Nonpathogen - flagella protein Mevan_0971 9 COG3351 FlaD, Putative archaeal flagellar protein D/E Cell motility and secretion 150399709 Nonpathogen - hypothetical protein Mevan_0961 2 None None None 150398766 Common - 5'-deoxyadenosylcobinamide phosphate nucleotidyltransferase Mevan_0006 47 COG2266 COG2266, GTP:adenosylcobinamide-phosphate guanylyltransferase Coenzyme metabolism 150400238 Common - cytidylate kinase Mevan_1499 36 COG1102 Cmk, Cytidylate kinase Nucleotide transport and metabolism 150400312 Common leuS leucyl-tRNA synthetase Mevan_1575 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150399316 Common - 6-pyruvoyl tetrahydropterin synthase Mevan_0564 35 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 150399140 Nonpathogen - Helix-turn-helix type 11 domain protein Mevan_0387 3 COG1959 COG1959, Predicted transcriptional regulator Transcription 150399424 Common - DNA-directed RNA polymerase subunit alpha Mevan_0673 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 150398944 Nonpathogen - hypothetical protein Mevan_0188 2 None None None 150399377 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit beta Mevan_0626 116 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 150400066 Nonpathogen - hypothetical protein Mevan_1324 3 None None None 150399407 Common - undecaprenyl diphosphate synthase Mevan_0656 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 150399570 Nonpathogen - hypothetical protein Mevan_0819 18 COG1885 COG1885, Uncharacterized protein conserved in archaea Function unknown 150400410 Common - beta-lactamase domain protein Mevan_1673 25 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 150399036 Common - transcriptional regulator, TetR family Mevan_0282 115 COG1309 AcrR, Transcriptional regulator Transcription 150399026 Common - aldo/keto reductase Mevan_0272 70 COG1453 COG1453, Predicted oxidoreductases of the aldo/keto reductase family General function prediction only 150400233 Common - Xylose isomerase domain protein TIM barrel Mevan_1494 16 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 150399748 Nonpathogen - hypothetical protein Mevan_1000 33 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 150399044 Nonpathogen - Protein of unknown function DUF509 Mevan_0290 4 COG1617 COG1617, Uncharacterized conserved protein Function unknown 150400175 Nonpathogen - hypothetical protein Mevan_1435 13 COG1255 COG1255, Uncharacterized protein conserved in archaea Function unknown 150399741 Common - molybdopterin oxidoreductase Mevan_0993 82 COG1029 FwdB, Formylmethanofuran dehydrogenase subunit B Energy production and conversion 150399308 Common - quinolinate synthetase Mevan_0556 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 150399331 Common - glutamyl-tRNA(Gln) amidotransferase subunit D Mevan_0579 141 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 150399000 Common - cytidyltransferase-related domain Mevan_0246 135 COG0615 TagD, Cytidylyltransferase Cell envelope biogenesis, outer membrane / Lipid metabolism 150399904 Nonpathogen - 30S ribosomal protein S19e Mevan_1161 34 COG2238 RPS19A, Ribosomal protein S19E (S16A) Translation, ribosomal structure and biogenesis 150399113 Common - band 7 protein Mevan_0359 221 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 150400082 Nonpathogen - hypothetical protein Mevan_1340 2 COG4013 COG4013, Uncharacterized protein conserved in archaea Function unknown 150399984 Nonpathogen - N(2),N(2)-dimethylguanosine tRNA methyltransferase Mevan_1242 38 COG1867 TRM1, N2,N2-dimethylguanosine tRNA methyltransferase Translation, ribosomal structure and biogenesis 150399663 Common - methyltransferase small Mevan_0913 14 COG4076 COG4076, Predicted RNA methylase General function prediction only 150400151 Common - protein of unknown function DUF1121 Mevan_1410 21 None None None 150399506 Common - methionine aminopeptidase Mevan_0755 183 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 150400363 Nonpathogen - hypothetical protein Mevan_1626 1 None None None 150399873 Common purT phosphoribosylglycinamide formyltransferase 2 Mevan_1128 211 COG0027 PurT, Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) Nucleotide transport and metabolism 150400276 Common - ketol-acid reductoisomerase Mevan_1538 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 150400430 Common - 3-isopropylmalate dehydrogenase Mevan_1693 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 150399139 Common - putative adenylyl cyclase CyaB Mevan_0386 34 COG1437 CyaB, Adenylate cyclase, class 2 (thermophilic) Nucleotide transport and metabolism 150400025 Common - cobalamin synthesis protein P47K Mevan_1283 64 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 150399818 Common - methylenetetrahydromethanopterin reductase Mevan_1073 66 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 150399457 Common - ERCC4 domain protein Mevan_0706 54 COG1111 MPH1, ERCC4-like helicases DNA replication, recombination, and repair 150400394 Nonpathogen - hypothetical protein Mevan_1657 3 COG5428 COG5428, Uncharacterized conserved small protein Function unknown 150400372 Nonpathogen - hypothetical protein Mevan_1635 2 None None None 150399643 Common - putative DNA helicase Mevan_0893 97 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 150399969 Common - aldo/keto reductase Mevan_1226 182 COG1453 COG1453, Predicted oxidoreductases of the aldo/keto reductase family General function prediction only 150398846 Common - Superfamily I DNA and RNA helicase and helicase subunits-like protein Mevan_0087 94 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 150399852 Common - PHP domain protein Mevan_1107 34 COG1379 COG1379, Uncharacterized conserved protein Function unknown 150399171 Common - phosphopantetheine adenylyltransferase Mevan_0418 31 COG1019 COG1019, Predicted nucleotidyltransferase General function prediction only 150399623 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit E Mevan_0873 14 COG4059 MtrE, Tetrahydromethanopterin S-methyltransferase, subunit E Coenzyme metabolism 150399383 Common rps11p 30S ribosomal protein S11P Mevan_0632 248 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 150399523 Common - NADH ubiquinone oxidoreductase 20 kDa subunit Mevan_0772 192 COG3260 COG3260, Ni,Fe-hydrogenase III small subunit Energy production and conversion 150399976 Common - putative manganese-dependent inorganic pyrophosphatase Mevan_1233 54 COG1227 PPX1, Inorganic pyrophosphatase/exopolyphosphatase Energy production and conversion 150400106 Nonpathogen - ATP dependent DNA ligase Mevan_1364 19 COG1423 COG1423, ATP-dependent DNA ligase, homolog of eukaryotic ligase III DNA replication, recombination, and repair 150398819 Common - nitrogenase MoFe cofactor biosynthesis protein NifE Mevan_0060 61 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 150400170 Nonpathogen - 30S ribosomal protein S27ae Mevan_1429 22 COG1998 RPS31, Ribosomal protein S27AE Translation, ribosomal structure and biogenesis 150399130 Common - CoB--CoM heterodisulfide reductase Mevan_0376 90 COG2048 HdrB, Heterodisulfide reductase, subunit B Energy production and conversion 150399382 Common rps4p 30S ribosomal protein S4 Mevan_0631 195 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 150400422 Common - protein tyrosine phosphatase Mevan_1685 65 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 150399755 Nonpathogen - Creatininase Mevan_1007 6 COG1402 COG1402, Uncharacterized protein, putative amidase General function prediction only 150400224 Nonpathogen - hypothetical protein Mevan_1485 1 COG2835 COG2835, Uncharacterized conserved protein Function unknown 150400208 Nonpathogen - fibrillarin Mevan_1469 34 COG1889 NOP1, Fibrillarin-like rRNA methylase Translation, ribosomal structure and biogenesis 150399092 Common gltX glutamyl-tRNA synthetase Mevan_0338 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 150398784 Common - polysaccharide biosynthesis protein Mevan_0024 38 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 150400166 Common - DNA-directed RNA polymerase subunit E' Mevan_1425 75 COG1095 RPB7, DNA-directed RNA polymerase, subunit E' Transcription 150400427 Nonpathogen - Protein of unknown function DUF432 Mevan_1690 7 COG2430 COG2430, Uncharacterized conserved protein Function unknown 150399877 Nonpathogen - H(2)-dependent methylenetetrahydromethanopterin dehydrogenase Mevan_1132 6 COG4074 Mth, H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase Energy production and conversion 150399660 Nonpathogen - protein of unknown function DUF483 Mevan_0910 4 COG1790 COG1790, Uncharacterized protein conserved in archaea Function unknown 150398936 Common - MotA/TolQ/ExbB proton channel Mevan_0180 20 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 150398854 Common - filamentation induced by cAMP protein Fic Mevan_0095 39 COG3177 COG3177, Uncharacterized conserved protein Function unknown 150400132 Common - phosphoglycerate mutase 1 family Mevan_1390 162 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 150400101 Common - protein of unknown function UPF0126 Mevan_1359 132 COG2860 COG2860, Predicted membrane protein Function unknown 150399467 Common - 50S ribosomal protein L29 Mevan_0716 44 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 150398888 Nonpathogen - cellulosome anchoring protein cohesin region Mevan_0132 1 None None None 150399739 Common - thiamine pyrophosphate protein domain protein TPP-binding Mevan_0991 35 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 150398983 Common - CRISPR-associated protein Cas1 Mevan_0229 103 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 150399303 Nonpathogen - hypothetical protein Mevan_0551 1 None None None 150400120 Common - Serine--pyruvate transaminase Mevan_1378 172 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 150399322 Common - hypothetical protein Mevan_0570 6 None None None 150399227 Common - CoB--CoM heterodisulfide reductase Mevan_0475 104 COG2048 HdrB, Heterodisulfide reductase, subunit B Energy production and conversion 150399853 Common - putative transcriptional regulator, GntR family Mevan_1108 227 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 150398798 Common - AIR synthase related protein Mevan_0038 17 COG2144 COG2144, Selenophosphate synthetase-related proteins General function prediction only 150399730 Common - phosphoesterase RecJ domain protein Mevan_0982 33 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 150400338 Common - excinuclease ABC, A subunit Mevan_1601 244 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 150399960 Common - protein of unknown function RIO1 Mevan_1217 47 COG0478 COG0478, RIO-like serine/threonine protein kinase fused to N-terminal HTH domain Signal transduction mechanisms 150399370 Nonpathogen - hypothetical protein Mevan_0619 7 COG4073 COG4073, Uncharacterized protein conserved in archaea Function unknown 150399285 Common - LOR/SDH bifunctional protein conserved domain protein Mevan_0533 33 COG1915 COG1915, Uncharacterized conserved protein Function unknown 150399158 Common - methyltransferase FkbM family Mevan_0405 8 None None None 150400246 Common - methyltransferase small Mevan_1507 47 COG2263 COG2263, Predicted RNA methylase Translation, ribosomal structure and biogenesis 150399083 Common - N-(5'-phosphoribosyl)anthranilate isomerase Mevan_0329 138 COG0135 TrpF, Phosphoribosylanthranilate isomerase Amino acid transport and metabolism 150399633 Common - hydrolase, TatD family Mevan_0883 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 150400087 Common - RNA methyltransferase, TrmH family, group 1 Mevan_1345 155 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 150399620 Nonpathogen - Methyl-coenzyme M reductase operon protein C Mevan_0870 14 COG4056 McrC, Methyl coenzyme M reductase, subunit C Coenzyme metabolism 150399542 Nonpathogen - cobalt transport protein CbiN Mevan_0791 2 COG1930 CbiN, ABC-type cobalt transport system, periplasmic component Inorganic ion transport and metabolism 150399989 Nonpathogen - hypothetical protein Mevan_1247 3 COG1627 COG1627, Uncharacterized protein conserved in archaea Function unknown 150399839 Common - glutamate synthase alpha subunit domain protein Mevan_1094 45 COG0070 GltB, Glutamate synthase domain 3 Amino acid transport and metabolism 150399951 Common - argininosuccinate lyase Mevan_1208 239 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 150400006 Common - proteasome subunit alpha Mevan_1264 44 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 150399927 Nonpathogen - riboflavin synthase Mevan_1184 22 COG1731 COG1731, Archaeal riboflavin synthase Coenzyme metabolism 150398967 Common - dihydroorotate dehydrogenase electron transfer subunit Mevan_0212 94 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 150400424 Nonpathogen - DNA polymerase beta domain protein region Mevan_1687 1 COG1510 COG1510, Predicted transcriptional regulators Transcription 150399262 Nonpathogen - surface protein, anchor region Mevan_0510 1 None None None 150399920 Nonpathogen - Mur ligase middle domain protein Mevan_1177 7 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 150399801 Nonpathogen tfb transcription initiation factor IIB Mevan_1056 34 COG1405 SUA7, Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB Transcription 150398955 Nonpathogen - hypothetical protein Mevan_0200 3 None None None 150399776 Nonpathogen - hypothetical protein Mevan_1028 2 None None None 150399999 Common - phosphoesterase RecJ domain protein Mevan_1257 32 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 150399271 Common - peptidase M24 Mevan_0519 245 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 150398796 Nonpathogen - hypothetical protein Mevan_0036 1 None None None 150399943 Nonpathogen - hypothetical protein Mevan_1200 8 COG4079 COG4079, Uncharacterized protein conserved in archaea Function unknown 150399619 Nonpathogen - Methyl-coenzyme M reductase, protein D Mevan_0869 14 COG4055 McrD, Methyl coenzyme M reductase, subunit D Coenzyme metabolism 150399958 Common - 3-dehydroquinate synthase Mevan_1215 28 COG1465 COG1465, Predicted alternative 3-dehydroquinate synthase Amino acid transport and metabolism 150399341 Common - CrcB protein Mevan_0590 78 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 150400437 Common - AMMECR1 domain protein Mevan_1700 77 COG2078 AMMECR1, Uncharacterized conserved protein Function unknown 150398829 Common - nickel-dependent hydrogenase large subunit Mevan_0070 110 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 150398970 Common - putative phage infection protein Mevan_0215 3 None None None 150400299 Common - regulatory protein, MarR Mevan_1562 14 COG1510 COG1510, Predicted transcriptional regulators Transcription 150399180 Common - phospholipase D/Transphosphatidylase Mevan_0427 19 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 150399599 Nonpathogen - protein of unknown function DUF112 transmembrane Mevan_0848 22 COG1784 COG1784, Predicted membrane protein Function unknown 150400300 Common - ABC transporter related Mevan_1563 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 150400074 Nonpathogen - protein of unknown function DUF447 Mevan_1332 5 COG2457 COG2457, Uncharacterized conserved protein Function unknown 150399203 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Mevan_0451 200 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 150399559 Nonpathogen - hypothetical protein Mevan_0808 11 COG4800 COG4800, Predicted transcriptional regulator with an HTH domain Transcription 150399829 Nonpathogen - putative DNA primase, small subunit Mevan_1084 32 COG1467 PRI1, Eukaryotic-type DNA primase, catalytic (small) subunit DNA replication, recombination, and repair 150400072 Common - precorrin-2 C20-methyltransferase Mevan_1330 126 COG2243 CobF, Precorrin-2 methylase Coenzyme metabolism 150399427 Common - transcription elongation factor NusA-like protein Mevan_0676 47 COG0195 NusA, Transcription elongation factor Transcription 150400408 Common - protein of unknown function UPF0118 Mevan_1671 135 COG0628 PerM, Predicted permease General function prediction only 150398993 Common - Protein of unknown function DUF530 Mevan_0239 6 COG1771 COG1771, Uncharacterized protein conserved in archaea Function unknown 150399592 Common - prephenate dehydratase Mevan_0841 214 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 150399254 Common - peptidase S16, Lon-like protease Mevan_0502 142 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 150399103 Nonpathogen - hypothetical protein Mevan_0349 2 None None None 150399562 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0811 187 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 150398979 Common - chaperonin GroEL Mevan_0224 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 150399992 Nonpathogen - hypothetical protein Mevan_1250 2 None None None 150399671 Nonpathogen - protein of unknown function RIO1 Mevan_0922 14 COG2112 COG2112, Predicted Ser/Thr protein kinase Signal transduction mechanisms 150399519 Common - NADH dehydrogenase (ubiquinone) Mevan_0768 74 COG0650 HyfC, Formate hydrogenlyase subunit 4 Energy production and conversion 150400059 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Mevan_1317 107 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 150399931 Common - Sua5/YciO/YrdC/YwlC family protein Mevan_1188 223 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 150399478 Nonpathogen rpl32e 50S ribosomal protein L32e Mevan_0727 34 COG1717 RPL32, Ribosomal protein L32E Translation, ribosomal structure and biogenesis 150399439 Nonpathogen - hypothetical protein Mevan_0688 1 None None None 150399358 Nonpathogen - coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein Mevan_0607 30 COG1035 FrhB, Coenzyme F420-reducing hydrogenase, beta subunit Energy production and conversion 150398805 Nonpathogen - S-layer protein Mevan_0045 4 None None None 150399938 Common - lysine 2,3-aminomutase YodO family protein Mevan_1195 128 COG1509 KamA, Lysine 2,3-aminomutase Amino acid transport and metabolism 150398889 Nonpathogen - hypothetical protein Mevan_0133 1 None None None 150399705 Common - protein of unknown function DUF43 Mevan_0957 17 COG1568 COG1568, Predicted methyltransferases General function prediction only 150400079 Common metG methionyl-tRNA synthetase Mevan_1337 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150399786 Nonpathogen tfb transcription initiation factor IIB Mevan_1038 34 COG1405 SUA7, Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB Transcription 150400189 Nonpathogen rps17E 30S ribosomal protein S17e Mevan_1450 34 COG1383 RPS17A, Ribosomal protein S17E Translation, ribosomal structure and biogenesis 150400032 Common - beta-ribofuranosylaminobenzene 5'-phosphate synthase family Mevan_1290 37 COG1907 COG1907, Predicted archaeal sugar kinases General function prediction only 150399655 Nonpathogen - domain of unknown function DUF1743 Mevan_0905 15 COG1571 COG1571, Predicted DNA-binding protein containing a Zn-ribbon domain General function prediction only 150399238 Common - NADPH-dependent FMN reductase Mevan_0486 42 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 150399444 Common - coenzyme F420-reducing hydrogenase delta subunit Mevan_0693 47 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 150399797 Nonpathogen - H/ACA RNA-protein complex component Gar1 Mevan_1051 2 COG3277 GAR1, RNA-binding protein involved in rRNA processing Translation, ribosomal structure and biogenesis 150400414 Nonpathogen - hypothetical protein Mevan_1677 12 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 150399572 Nonpathogen - hypothetical protein Mevan_0821 1 None None None 150400252 Common - Na+ antiporter NhaC Mevan_1513 69 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 150399399 Common - coenzyme F420-reducing hydrogenase delta subunit Mevan_0648 34 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 150399492 Common - cation transporter Mevan_0741 121 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 150399549 Common - ATP-NAD/AcoX kinase Mevan_0798 242 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 150398822 Common - nitrogen regulatory protein P-II Mevan_0063 180 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 150400257 Common - TPR repeat-containing protein Mevan_1518 124 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 150399915 Common - daunorubicin resistance ABC transporter ATPase subunit Mevan_1172 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 150399815 Nonpathogen - PUA domain containing protein Mevan_1070 34 COG2016 COG2016, Predicted RNA-binding protein (contains PUA domain) Translation, ribosomal structure and biogenesis 150399405 Common - hypothetical protein Mevan_0654 17 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 150399219 Common - cell division ATPase MinD Mevan_0467 212 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 150399231 Common - Ferritin Dps family protein Mevan_0479 85 COG1528 Ftn, Ferritin-like protein Inorganic ion transport and metabolism 150398920 Common - chymotrypsin serine protease, family S1 Mevan_0164 21 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 150400147 Common - PfkB domain protein Mevan_1406 202 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 150399050 Nonpathogen - hypothetical protein Mevan_0296 20 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 150399843 Nonpathogen - hypothetical protein Mevan_1098 17 COG1356 COG1356, Uncharacterized protein conserved in archaea Function unknown 150400214 Nonpathogen - translation initiation factor IF-1A Mevan_1475 34 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 150399499 Common - DNA topoisomerase VI subunit A Mevan_0748 34 COG1697 COG1697, DNA topoisomerase VI, subunit A DNA replication, recombination, and repair 150399678 Nonpathogen - hypothetical protein Mevan_0929 1 None None None 150398907 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Mevan_0151 249 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 150399697 Nonpathogen - hypothetical protein Mevan_0949 14 COG4022 COG4022, Uncharacterized protein conserved in archaea Function unknown 150399248 Common - periplasmic binding protein Mevan_0496 79 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 150398985 Common - CRISPR-associated protein, Csh2 family Mevan_0231 53 COG3649 COG3649, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 150399077 Common - blue (type 1) copper domain protein Mevan_0323 21 COG3794 PetE, Plastocyanin Energy production and conversion 150398834 Common - Coenzyme F420 hydrogenase Mevan_0075 80 COG1941 FrhG, Coenzyme F420-reducing hydrogenase, gamma subunit Energy production and conversion 150400039 Common - TrkA-N domain protein Mevan_1297 70 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 150400113 Nonpathogen - hypothetical protein Mevan_1371 1 COG4068 COG4068, Uncharacterized protein containing a Zn-ribbon Function unknown 150399585 Nonpathogen - hypothetical protein Mevan_0834 5 COG4077 COG4077, Uncharacterized protein conserved in archaea Function unknown 150399833 Common - Abortive infection protein Mevan_1088 7 None None None 150400051 Nonpathogen - 50S ribosomal protein L15e Mevan_1309 34 COG1632 RPL15A, Ribosomal protein L15E Translation, ribosomal structure and biogenesis 150400118 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_1376 33 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 150399224 Nonpathogen - putative signal transduction protein with CBS domains Mevan_0472 8 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 150398782 Common - ATP/GTP-binding site motif A (P-loop) Mevan_0022 29 COG2603 COG2603, Predicted ATPase General function prediction only 150398812 Common - binding-protein-dependent transport systems inner membrane component Mevan_0053 190 COG4176 ProW, ABC-type proline/glycine betaine transport system, permease component Amino acid transport and metabolism 150400197 Common - HhH-GPD family protein Mevan_1458 95 COG2231 COG2231, Uncharacterized protein related to Endonuclease III DNA replication, recombination, and repair 150399552 Common - orotate phosphoribosyltransferase Mevan_0801 164 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 150399929 Nonpathogen - protein of unknown function DUF120 Mevan_1186 31 COG1339 COG1339, Transcriptional regulator of a riboflavin/FAD biosynthetic operon Transcription / Coenzyme metabolism 150399099 Common - putative signal transduction protein with CBS domains Mevan_0345 146 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 150399168 Common - NAD-dependent epimerase/dehydratase Mevan_0415 234 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 150399313 Nonpathogen - molydopterin dinucleotide-binding region Mevan_0561 15 COG1153 FwdD, Formylmethanofuran dehydrogenase subunit D Energy production and conversion 150398771 Nonpathogen - hypothetical protein Mevan_0011 1 None None None 150400292 Nonpathogen - Ribosomal protein L24E Mevan_1555 31 COG2075 RPL24A, Ribosomal protein L24E Translation, ribosomal structure and biogenesis 150399115 Nonpathogen - A1A0 ATPase, subunit H Mevan_0361 1 None None None 150399850 Nonpathogen - 50S ribosomal protein L21e Mevan_1105 34 COG2139 RPL21A, Ribosomal protein L21E Translation, ribosomal structure and biogenesis 150400084 Common - histidine triad (HIT) protein Mevan_1342 239 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 150398957 Common - polysaccharide biosynthesis protein Mevan_0202 28 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 150400344 Common - L-aspartate dehydrogenase Mevan_1607 52 COG1712 COG1712, Predicted dinucleotide-utilizing enzyme General function prediction only 150399513 Nonpathogen - hypothetical protein Mevan_0762 2 COG4039 COG4039, Predicted membrane protein Function unknown 150399043 Common - uroporphyrin-III C-methyltransferase Mevan_0289 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 150398894 Common - putative CheW protein Mevan_0138 132 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 150399320 Common - phosphoribosylaminoimidazole synthetase Mevan_0568 232 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 150399151 Common - deoxyUTP pyrophosphatase Mevan_0398 28 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 150399811 Common hisE phosphoribosyl-ATP pyrophosphatase Mevan_1066 174 COG0140 HisI, Phosphoribosyl-ATP pyrophosphohydrolase Amino acid transport and metabolism 150400035 Common - phosphoribosylaminoimidazole carboxylase, catalytic subunit Mevan_1293 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 150400412 Common - hypothetical protein Mevan_1675 5 None None None 150400103 Nonpathogen - hypothetical protein Mevan_1361 1 None None None 150400177 Nonpathogen - protein of unknown function Met10 Mevan_1437 34 COG2520 COG2520, Predicted methyltransferase General function prediction only 150399028 Common - protein of unknown function DUF111 Mevan_0274 64 COG1641 COG1641, Uncharacterized conserved protein Function unknown 150399902 Nonpathogen - hypothetical protein Mevan_1159 14 COG4070 COG4070, Predicted peptidyl-prolyl cis-trans isomerase (rotamase), cyclophilin family Posttranslational modification, protein turnover, chaperones 150399726 Common - Xylose isomerase domain protein TIM barrel Mevan_0978 29 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 150399674 Common - protein of unknown function DUF59 Mevan_0925 90 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 150400014 Nonpathogen rplP0 acidic ribosomal protein P0 Mevan_1272 33 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 150400169 Nonpathogen rps24e 30S ribosomal protein S24e Mevan_1428 22 COG2004 RPS24A, Ribosomal protein S24E Translation, ribosomal structure and biogenesis 150400236 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Mevan_1497 22 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 150400286 Common - cation diffusion facilitator family transporter Mevan_1549 214 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 150399200 Nonpathogen - hypothetical protein Mevan_0448 2 COG4083 COG4083, Predicted membrane protein Function unknown 150400361 Common - protein of unknown function DUF74 Mevan_1624 106 COG0393 COG0393, Uncharacterized conserved protein Function unknown 150399005 Common - cobalamin 5'-phosphate synthase Mevan_0251 28 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 150399823 Common - acetylglutamate kinase Mevan_1078 217 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 150399220 Common - amidophosphoribosyltransferase Mevan_0468 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 150400436 Common - molybdenum cofactor synthesis domain Mevan_1699 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 150399760 Nonpathogen - hypothetical protein Mevan_1012 2 COG1711 COG1711, Uncharacterized protein conserved in archaea Function unknown 150399875 Nonpathogen - conserved fibrillarin-like protein Mevan_1130 7 COG4018 COG4018, Uncharacterized protein conserved in archaea Function unknown 150399338 Common - Cupin 2 conserved barrel domain protein Mevan_0587 75 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 150399305 Common - hypothetical protein Mevan_0553 65 COG1606 COG1606, ATP-utilizing enzymes of the PP-loop superfamily General function prediction only 150398844 Common - UvrD/REP helicase Mevan_0085 233 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 150399625 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit C Mevan_0875 14 COG4061 MtrC, Tetrahydromethanopterin S-methyltransferase, subunit C Coenzyme metabolism 150399768 Nonpathogen - Protein of unknown function DUF1495 Mevan_1020 6 COG3373 COG3373, Uncharacterized protein conserved in archaea Function unknown 150399031 Common - phosphoribosylaminoimidazole carboxylase related protein Mevan_0277 64 COG1691 COG1691, NCAIR mutase (PurE)-related proteins General function prediction only 150398961 Common - transferase hexapeptide repeat protein Mevan_0206 101 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 150399737 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0989 56 COG1146 COG1146, Ferredoxin Energy production and conversion 150399714 Nonpathogen - flagellin protein Mevan_0966 8 COG1681 FlaB, Archaeal flagellins Cell motility and secretion 150399133 Common - protein of unknown function DUF181 Mevan_0379 53 COG1944 COG1944, Uncharacterized conserved protein Function unknown 150400314 Common - MATE efflux family protein Mevan_1577 149 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 150399805 Common - Polyprenyl synthetase Mevan_1060 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 150398950 Nonpathogen - Protein of unknown function DUF1616 Mevan_0195 16 COG4743 COG4743, Predicted membrane protein Function unknown 150399614 Common - NADPH-dependent F420 reductase Mevan_0864 45 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 150400042 Common - hydrogenase expression/formation protein HypD Mevan_1300 109 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 150399367 Nonpathogen - Protein of unknown function DUF137 Mevan_0616 30 COG1701 COG1701, Uncharacterized protein conserved in archaea Function unknown 150399435 Common - ribonuclease HII Mevan_0684 150 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 150399909 Common - 2-phosphosulfolactate phosphatase Mevan_1166 40 COG2045 COG2045, Phosphosulfolactate phosphohydrolase and related enzymes Coenzyme metabolism / General function prediction only 150398878 Nonpathogen - hypothetical protein Mevan_0121 1 None None None 150398934 Common - cysteine synthase A Mevan_0178 221 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 150399859 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_1114 45 COG2768 COG2768, Uncharacterized Fe-S center protein General function prediction only 150399318 Common - CBS domain containing protein Mevan_0566 151 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 150400392 Nonpathogen - addiction module toxin, RelE/StbE family Mevan_1655 1 COG3041 COG3041, Uncharacterized protein conserved in bacteria Function unknown 150399343 Nonpathogen - hypothetical protein Mevan_0592 35 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 150400334 Nonpathogen - hypothetical protein Mevan_1597 3 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 150399094 Common - extracellular solute-binding protein family 3 Mevan_0340 159 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 150399469 Nonpathogen - ribonuclease P protein component 1 Mevan_0718 22 COG1588 POP4, RNase P/RNase MRP subunit p29 Translation, ribosomal structure and biogenesis 150398868 Common - CRISPR-associated RAMP protein, Cmr6 family Mevan_0110 12 COG1604 COG1604, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 150399038 Nonpathogen - hypothetical protein Mevan_0284 1 None None None 150399360 Common - carbonic anhydrase Mevan_0609 59 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 150398856 Nonpathogen - hypothetical protein Mevan_0097 1 None None None 150398981 Common - CRISPR-associated protein Cas4 Mevan_0227 8 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 150400336 Common - excinuclease ABC subunit B Mevan_1599 226 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 150400134 Common - LPPG domain containing protein Mevan_1392 39 COG0391 COG0391, Uncharacterized conserved protein Function unknown 150399283 Common - histidinol-phosphate aminotransferase Mevan_0531 240 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 150399063 Common - acetyl-CoA decarbonylase/synthase complex subunit beta Mevan_0309 19 COG1614 CdhC, CO dehydrogenase/acetyl-CoA synthase beta subunit Energy production and conversion 150399415 Common - thiamine biosynthesis/tRNA modification protein ThiI Mevan_0664 94 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 150399325 Common - hypothetical protein Mevan_0573 31 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 150400089 Nonpathogen - Resolvase, Holliday junction-type Mevan_1347 13 COG1591 COG1591, Holliday junction resolvase - archaeal type DNA replication, recombination, and repair 150400329 Nonpathogen - hypothetical protein Mevan_1592 1 None None None 150400226 Common - NADPH-dependent FMN reductase Mevan_1487 47 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 150398786 Common - Tetratricopeptide TPR_2 repeat protein Mevan_0026 26 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 150399085 Common - anthranilate synthase component I Mevan_0331 223 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 150399502 Common - Wyosine base formation domain protein Mevan_0751 35 COG0731 COG0731, Fe-S oxidoreductases Energy production and conversion 150399380 Common - lysyl-tRNA synthetase Mevan_0629 77 COG1384 LysS, Lysyl-tRNA synthetase (class I) Translation, ribosomal structure and biogenesis 150399474 Common rpl5p 50S ribosomal protein L5P Mevan_0723 248 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 150399665 Nonpathogen - hypothetical protein Mevan_0915 2 None None None 150400316 Nonpathogen - hypothetical protein Mevan_1579 10 COG4081 COG4081, Uncharacterized protein conserved in archaea Function unknown 150400367 Nonpathogen - hypothetical protein Mevan_1630 1 None None None 150400278 Common - Bile acid:sodium symporter Mevan_1540 102 COG0385 COG0385, Predicted Na+-dependent transporter General function prediction only 150399896 Common - nitrogenase reductase-like protein Mevan_1152 123 COG1348 NifH, Nitrogenase subunit NifH (ATPase) Inorganic ion transport and metabolism 150399987 Nonpathogen - peptidase A24A prepilin type IV Mevan_1245 5 COG4960 CpaA, Flp pilus assembly protein, protease CpaA Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 150399178 Nonpathogen - transcriptional regulator, TrmB Mevan_0425 5 COG5625 COG5625, Predicted transcription regulator containing HTH domain Transcription 150399982 Common - exsB protein Mevan_1240 175 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 150400374 Nonpathogen - hypothetical protein Mevan_1637 2 None None None 150398861 Common - ATPase Mevan_0103 43 COG3950 COG3950, Predicted ATP-binding protein involved in virulence General function prediction only 150400108 Common - amidohydrolase Mevan_1366 170 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 150399448 Common - protein of unknown function DUF52 Mevan_0697 66 COG1355 COG1355, Predicted dioxygenase General function prediction only 150400219 Common - putative CoA-substrate-specific enzyme activase Mevan_1480 64 COG1924 COG1924, Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) Lipid metabolism 150399645 Common - S-adenosylmethionine decarboxylase related Mevan_0895 75 COG1586 SpeD, S-adenosylmethionine decarboxylase Amino acid transport and metabolism 150400049 Nonpathogen - NMD3 Mevan_1307 33 COG1499 NMD3, NMD protein affecting ribosome stability and mRNA decay Translation, ribosomal structure and biogenesis 150399013 Common - Protein-glutamate O-methyltransferase Mevan_0259 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 150398764 Common - Diaminopimelate epimerase Mevan_0004 203 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 150399974 Common - heavy metal translocating P-type ATPase Mevan_1231 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 150399891 Common - thiamine pyrophosphate protein domain protein TPP-binding Mevan_1147 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 150398800 Common - isopropylmalate/isohomocitrate dehydrogenase Mevan_0040 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 150399508 Nonpathogen - ZPR1-like zinc finger protein Mevan_0757 29 COG1779 COG1779, C4-type Zn-finger protein General function prediction only 150400027 Common - Phosphosulfolactate synthase Mevan_1285 22 COG1809 COG1809, Uncharacterized conserved protein Function unknown 150400385 Nonpathogen - hypothetical protein Mevan_1648 1 None None None 150400091 Common - hypothetical protein Mevan_1349 40 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 150399547 Common - aldehyde dehydrogenase Mevan_0796 224 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 150399879 Common - hypothetical protein Mevan_1134 37 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 150400094 Nonpathogen - flagella protein F Mevan_1352 1 COG3353 FlaF, Putative archaeal flagellar protein F Cell motility and secretion 150399865 Common - nitroreductase Mevan_1120 102 COG0778 NfnB, Nitroreductase Energy production and conversion 150400037 Common - Nucleoside-diphosphate kinase Mevan_1295 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 150399869 Common - biotin--acetyl-CoA-carboxylase ligase Mevan_1124 206 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 150398977 Common - methyl-accepting chemotaxis sensory transducer Mevan_0222 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 150399746 Nonpathogen - methyl-viologen-reducing hydrogenase delta subunit Mevan_0998 32 COG1908 FrhD, Coenzyme F420-reducing hydrogenase, delta subunit Energy production and conversion 150400194 Common - hypothetical protein Mevan_1455 57 COG1237 COG1237, Metal-dependent hydrolases of the beta-lactamase superfamily II General function prediction only 150399280 Common - protein of unknown function DUF35 Mevan_0528 63 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 150398807 Common - Tetratricopeptide TPR_2 repeat protein Mevan_0047 51 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 150399480 Common rpl18p 50S ribosomal protein L18P Mevan_0729 36 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 150399673 Common hisS histidyl-tRNA synthetase Mevan_0924 249 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150399120 Common - V-type ATP synthase subunit F Mevan_0366 14 COG1436 NtpG, Archaeal/vacuolar-type H+-ATPase subunit F Energy production and conversion 150400057 Common - protein of unknown function DUF255 Mevan_1315 105 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 150400217 Common - ribosomal RNA methyltransferase RrmJ/FtsJ Mevan_1478 139 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 150399433 Common - Phosphomannomutase Mevan_0682 242 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 150399141 Nonpathogen - Helix-turn-helix type 11 domain protein Mevan_0388 3 COG1959 COG1959, Predicted transcriptional regulator Transcription 150400030 Common - TraB family protein Mevan_1288 39 COG1916 COG1916, Uncharacterized homolog of PrgY (pheromone shutdown protein) Function unknown 150398814 Common - aminotransferase class-III Mevan_0055 236 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 150398914 Common - DNA topoisomerase I Mevan_0158 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 150400008 Common - CoA-binding domain protein Mevan_1266 192 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 150399259 Common - N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase Mevan_0507 27 COG3252 COG3252, Methenyltetrahydromethanopterin cyclohydrolase Coenzyme metabolism 150399597 Nonpathogen - hypothetical protein Mevan_0846 2 None None None 150399945 Common - hypothetical protein Mevan_1202 8 None None None 150399298 Nonpathogen - thiamine biosynthesis protein Mevan_0546 7 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 150399827 Common - methylated-DNA--protein-cysteine methyltransferase Mevan_1082 185 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 150399925 Common - phosphoribosylformylglycinamidine synthase I Mevan_1182 232 COG0047 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain Nucleotide transport and metabolism 150399127 Common - protein of unknown function DUF88 Mevan_0373 26 COG1432 COG1432, Uncharacterized conserved protein Function unknown 150399550 Nonpathogen - Chromatin associated protein KTI12 Mevan_0799 9 COG4088 COG4088, Predicted nucleotide kinase Nucleotide transport and metabolism 150399953 Common - protein of unknown function DUF124 Mevan_1210 66 COG2013 COG2013, Uncharacterized conserved protein Function unknown 150400183 Common - Cupin 2 conserved barrel domain protein Mevan_1444 115 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 150399808 Nonpathogen - hypothetical protein Mevan_1063 2 None None None 150399471 Common rpl14p 50S ribosomal protein L14P Mevan_0720 247 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 150399362 Common - formate/nitrite transporter Mevan_0611 96 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 150400012 Nonpathogen - transcription factor Mevan_1270 34 COG2101 SPT15, TATA-box binding protein (TBP), component of TFIID and TFIIIB Transcription 150400416 Nonpathogen - hypothetical protein Mevan_1679 1 None None None 150400212 Nonpathogen - hypothetical protein Mevan_1473 1 None None None 150400389 Nonpathogen - hypothetical protein Mevan_1652 1 None None None 150399289 Common radA DNA repair and recombination protein RadA Mevan_0537 50 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 150400406 Common - hypothetical protein Mevan_1669 81 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 150399832 Common - protein of unknown function UPF0153 Mevan_1087 28 COG2983 COG2983, Uncharacterized conserved protein Function unknown 150399837 Common - glutamine amidotransferase class-II Mevan_1092 61 COG0067 GltB, Glutamate synthase domain 1 Amino acid transport and metabolism 150399774 Nonpathogen - hypothetical protein Mevan_1026 6 None None None 150399297 Nonpathogen - putative HAD family hydrolase Mevan_0545 5 COG4087 COG4087, Soluble P-type ATPase General function prediction only 150399557 Nonpathogen - hypothetical protein Mevan_0806 6 COG4019 COG4019, Uncharacterized protein conserved in archaea Function unknown 150399689 Nonpathogen - redox-active disulfide protein 1 Mevan_0941 9 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 150400070 Common - protein of unknown function DUF100 Mevan_1328 37 COG1980 COG1980, Archaeal fructose 1,6-bisphosphatase Carbohydrate transport and metabolism 150399692 Common - Phosphomethylpyrimidine kinase Mevan_0944 199 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 150400044 Common - AIR synthase related protein Mevan_1302 41 COG1973 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 150399605 Nonpathogen - protein of unknown function UPF0132 Mevan_0854 10 COG4818 COG4818, Predicted membrane protein Function unknown 150399205 Nonpathogen - peptide chain release factor 1 Mevan_0453 34 COG1503 eRF1, Peptide chain release factor 1 (eRF1) Translation, ribosomal structure and biogenesis 150399260 Common - Radical SAM domain protein Mevan_0508 30 COG2108 COG2108, Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme General function prediction only 150399181 Common - TfuA domain protein core Mevan_0428 25 COG3482 COG3482, Uncharacterized conserved protein Function unknown 150400206 Nonpathogen - Soluble liver antigen/liver pancreas antigen Mevan_1467 3 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 150399278 Common - hypothetical protein Mevan_0526 162 COG3425 PksG, 3-hydroxy-3-methylglutaryl CoA synthase Lipid metabolism 150399695 Common - small GTP-binding protein Mevan_0947 161 COG0486 ThdF, Predicted GTPase General function prediction only 150399105 Common - protein of unknown function DUF814 Mevan_0351 52 COG1293 COG1293, Predicted RNA-binding protein homologous to eukaryotic snRNP Transcription 150400111 Common - putative ATPase RIL Mevan_1369 249 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 150398778 Nonpathogen - hypothetical protein Mevan_0018 2 None None None 150399267 Common - diaminopimelate decarboxylase Mevan_0515 219 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 150399079 Nonpathogen - hypothetical protein Mevan_0325 1 None None None 150400116 Nonpathogen - microsomal signal peptidase 21 KD subunit Mevan_1374 7 None None None 150398911 Common - type III restriction protein res subunit Mevan_0155 45 COG3587 COG3587, Restriction endonuclease Defense mechanisms 150400199 Common - Radical SAM domain protein Mevan_1460 32 COG1031 COG1031, Uncharacterized Fe-S oxidoreductase Energy production and conversion 150399587 Common secD preprotein translocase subunit SecD Mevan_0836 195 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 150400077 Nonpathogen - hypothetical protein Mevan_1335 6 COG1710 COG1710, Uncharacterized protein conserved in archaea Function unknown 150400302 Common - Rubrerythrin Mevan_1565 77 COG1592 COG1592, Rubrerythrin Energy production and conversion 150398788 Common - CTP synthetase Mevan_0028 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 150399222 Nonpathogen - Like-Sm ribonucleoprotein core Mevan_0470 31 COG1958 LSM1, Small nuclear ribonucleoprotein (snRNP) homolog Transcription 150399372 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0621 48 COG2768 COG2768, Uncharacterized Fe-S center protein General function prediction only 150400164 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_1423 18 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 150400244 Nonpathogen - triosephosphate isomerase Mevan_1505 34 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 150399487 Nonpathogen - tRNA 2'-O-methylase Mevan_0736 31 COG1303 COG1303, Uncharacterized protein conserved in archaea Function unknown 150400001 Nonpathogen - hypothetical protein Mevan_1259 3 COG2892 COG2892, Uncharacterized protein conserved in archaea Function unknown 150400250 Common - uracil-xanthine permease Mevan_1511 127 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 150399214 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0462 17 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 150400064 Nonpathogen - hypothetical protein Mevan_1322 11 COG4048 COG4048, Uncharacterized protein conserved in archaea Function unknown 150399398 Common - selenocysteine-specific translation elongation factor Mevan_0647 249 COG3276 SelB, Selenocysteine-specific translation elongation factor Translation, ribosomal structure and biogenesis 150399169 Common - UTP-glucose-1-phosphate uridylyltransferase Mevan_0416 234 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 150400290 Common rpl7ae 50S ribosomal protein L7Ae Mevan_1553 37 COG1358 RPL8A, Ribosomal protein HS6-type (S12/L30/L7a) Translation, ribosomal structure and biogenesis 150399590 Common - Ribonuclease III Mevan_0839 208 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 150398975 Common - CheA signal transduction histidine kinase Mevan_0220 148 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 150400383 Nonpathogen - hypothetical protein Mevan_1646 1 None None None 150400343 Nonpathogen - PRC-barrel domain protein Mevan_1606 11 COG1873 COG1873, Uncharacterized conserved protein Function unknown 150399403 Common - SMC domain protein Mevan_0652 146 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 150400261 Nonpathogen - 30S ribosomal protein S3Ae Mevan_1522 34 COG1890 RPS1A, Ribosomal protein S3AE Translation, ribosomal structure and biogenesis 150400141 Common - sulfopyruvate decarboxylase subunit alpha Mevan_1399 36 COG4032 COG4032, Predicted thiamine-pyrophosphate-binding protein General function prediction only 150399917 Common - peptidase M50 Mevan_1174 36 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 150399442 Common - beta-lactamase domain protein Mevan_0691 135 COG1782 COG1782, Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain General function prediction only 150399997 Nonpathogen - hypothetical protein Mevan_1255 2 None None None 150399074 Common - transcriptional regulator, XRE family Mevan_0320 65 COG1476 COG1476, Predicted transcriptional regulators Transcription 150399967 Nonpathogen - hypothetical protein Mevan_1224 1 None None None 150400148 Common - putative signal transduction protein with CBS domains Mevan_1407 80 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 150399795 Common - type II secretion system protein E Mevan_1049 223 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 150399574 Common - amino acid carrier protein Mevan_0823 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 150399753 Nonpathogen - hypothetical protein Mevan_1005 2 None None None 150399849 Nonpathogen - RNA polymerase Rpb4 Mevan_1104 16 COG1460 COG1460, Uncharacterized protein conserved in archaea Function unknown 150398904 Nonpathogen - zinc finger protein Mevan_0148 10 COG4855 COG4855, Uncharacterized protein conserved in archaea Function unknown 150399990 Nonpathogen - hypothetical protein Mevan_1248 2 None None None 150399534 Nonpathogen - Protein of unknown function DUF356 Mevan_0783 11 COG1844 COG1844, Uncharacterized protein conserved in archaea Function unknown 150399531 Nonpathogen - prefoldin, alpha subunit Mevan_0780 11 COG1730 GIM5, Predicted prefoldin, molecular chaperone implicated in de novo protein folding Posttranslational modification, protein turnover, chaperones 150399580 Common - chromosome segregation and condensation protein ScpA Mevan_0829 15 COG1354 COG1354, Uncharacterized conserved protein Function unknown 150398921 Nonpathogen - hypothetical protein Mevan_0165 2 None None None 150400397 Nonpathogen - hypothetical protein Mevan_1660 1 None None None 150399641 Nonpathogen rps15p 30S ribosomal protein S15P Mevan_0891 34 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 150398905 Nonpathogen - hypothetical protein Mevan_0149 10 COG4883 COG4883, Uncharacterized protein conserved in archaea Function unknown 150399701 Nonpathogen - hypothetical protein Mevan_0953 7 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 150399412 Common - Radical SAM domain protein Mevan_0661 231 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 150398883 Common - Cobaltochelatase Mevan_0126 89 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 150399634 Nonpathogen - nucleoside recognition domain protein Mevan_0884 14 COG3366 COG3366, Uncharacterized protein conserved in archaea Function unknown 150399340 Common - protein of unknown function DUF190 Mevan_0589 50 COG1993 COG1993, Uncharacterized conserved protein Function unknown 150398863 Common - hypothetical protein Mevan_0105 3 None None None 150399481 Common rps5p 30S ribosomal protein S5P Mevan_0730 203 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 150398763 Common - protein of unknown function DUF6 transmembrane Mevan_0003 138 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 150400284 Nonpathogen - hypothetical protein Mevan_1547 2 None None None 150399526 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0775 104 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 150399175 Common - phosphate ABC transporter, inner membrane subunit PstA Mevan_0422 230 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 150399389 Nonpathogen - RNA polymerase Rpb6 Mevan_0638 16 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 150399354 Common - glycosyl transferase group 1 Mevan_0603 232 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 150400376 Common - KAP P-loop domain protein Mevan_1639 28 COG4928 COG4928, Predicted P-loop ATPase General function prediction only 150399856 Common - major facilitator superfamily MFS_1 Mevan_1111 199 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 150399010 Common - response regulator receiver protein Mevan_0256 225 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 150400143 Common - methyl-accepting chemotaxis sensory transducer Mevan_1402 163 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 150399893 Common - 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase Mevan_1149 179 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 150399215 Common - DEAD/H associated domain protein Mevan_0463 158 COG1201 Lhr, Lhr-like helicases General function prediction only 150399957 Nonpathogen - hypothetical protein Mevan_1214 1 None None None 150399049 Common - transcriptional regulator, MarR family Mevan_0295 36 COG1846 MarR, Transcriptional regulators Transcription 150398843 Nonpathogen - CRISPR locus-related DNA-binding protein Mevan_0084 3 COG1846 MarR, Transcriptional regulators Transcription 150400260 Common - protein of unknown function DUF6 transmembrane Mevan_1521 146 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 150400353 Common - ABC transporter related Mevan_1616 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 150400021 Nonpathogen - hypothetical protein Mevan_1279 6 COG4053 COG4053, Uncharacterized protein conserved in archaea Function unknown 150399971 Common - triphosphoribosyl-dephospho-CoA protein Mevan_1228 30 COG1767 CitG, Triphosphoribosyl-dephospho-CoA synthetase Coenzyme metabolism 150399965 Common - GCN5-related N-acetyltransferase Mevan_1222 19 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 150398851 Common - hypothetical protein Mevan_0092 3 COG5022 COG5022, Myosin heavy chain Cytoskeleton 150399386 Nonpathogen rpl13p 50S ribosomal protein L13P Mevan_0635 34 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 150399575 Common - alanine racemase Mevan_0824 200 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 150398987 Common - CRISPR-associated helicase Cas3 Mevan_0233 80 COG1203 COG1203, Predicted helicases General function prediction only 150398901 Common - zinc finger CDGSH-type domain protein Mevan_0145 14 COG3369 COG3369, Uncharacterized conserved protein Function unknown 150400029 Common - periplasmic copper-binding Mevan_1287 48 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 150399281 Nonpathogen - hypothetical protein Mevan_0529 1 None None None 150399462 Nonpathogen - Protein of unknown function DUF1610 Mevan_0711 31 COG2888 COG2888, Predicted Zn-ribbon RNA-binding protein with a function in translation Translation, ribosomal structure and biogenesis 150399395 Common - chorismate synthase Mevan_0644 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 150398858 Nonpathogen - hypothetical protein Mevan_0099 2 None None None 150400227 Common - tRNA pseudouridine synthase D TruD Mevan_1488 91 COG0585 COG0585, Uncharacterized conserved protein Function unknown 150399813 Common - protein of unknown function DUF34 Mevan_1068 111 COG0327 COG0327, Uncharacterized conserved protein Function unknown 150400390 Nonpathogen - transcriptional regulator PadR family protein Mevan_1653 2 COG1733 COG1733, Predicted transcriptional regulators Transcription 150399488 Common - deoxycytidine triphosphate deaminase Mevan_0737 88 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 150399566 Common - pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit Mevan_0815 78 COG1144 COG1144, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit Energy production and conversion 150399857 Common - protein-L-isoaspartate O-methyltransferase Mevan_1112 167 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 150398996 Common hisG ATP phosphoribosyltransferase Mevan_0242 214 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 150400327 Common - Phenylacetate--CoA ligase Mevan_1590 123 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 150400348 Common - Lysine exporter protein (LYSE/YGGA) Mevan_1611 122 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 150400365 Common - phage integrase family protein Mevan_1628 156 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 150398931 Common - PP-loop domain protein Mevan_0175 167 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 150398980 Common - chaperonin Cpn10 Mevan_0225 213 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 150399646 Common - spermidine synthase Mevan_0896 126 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 150400105 Common - Radical SAM domain protein Mevan_1363 36 COG2100 COG2100, Predicted Fe-S oxidoreductase General function prediction only 150398772 Common - SNARE associated Golgi protein Mevan_0012 140 COG1238 COG1238, Predicted membrane protein Function unknown 150399345 Common - DEAD/DEAH box helicase domain protein Mevan_0594 153 COG1202 COG1202, Superfamily II helicase, archaea-specific General function prediction only 150399509 Nonpathogen - putative transcriptional regulator, XRE family Mevan_0758 2 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 150399359 Common - formate dehydrogenase, alpha subunit Mevan_0608 204 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 150399884 Nonpathogen - hypothetical protein Mevan_1139 6 COG1645 COG1645, Uncharacterized Zn-finger containing protein General function prediction only 150400139 Nonpathogen - hypothetical protein Mevan_1397 8 COG0579 COG0579, Predicted dehydrogenase General function prediction only 150400158 Common - TatD-related deoxyribonuclease Mevan_1417 24 COG1099 COG1099, Predicted metal-dependent hydrolases with the TIM-barrel fold General function prediction only 150399329 Common - protein of unknown function DUF87 Mevan_0577 92 COG0433 COG0433, Predicted ATPase General function prediction only 150399163 Common - polysaccharide biosynthesis protein CapD Mevan_0410 143 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 150399326 Nonpathogen - hypothetical protein Mevan_0574 7 None None None 150399724 Nonpathogen - flagellar assembly protein J Mevan_0976 18 COG1955 FlaJ, Archaeal flagella assembly protein J Cell motility and secretion / Intracellular trafficking and secretion 150399504 Common - regulatory protein ArsR Mevan_0753 176 COG0640 ArsR, Predicted transcriptional regulators Transcription 150398891 Common - hypothetical protein Mevan_0135 4 COG1572 COG1572, Uncharacterized conserved protein Function unknown 150400181 Common - acyl-CoA synthetase Mevan_1442 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 150399822 Nonpathogen - 50S ribosomal protein L31e Mevan_1077 21 COG2097 RPL31A, Ribosomal protein L31E Translation, ribosomal structure and biogenesis 150399771 Common - hypothetical protein Mevan_1023 70 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 150400281 Common - Carbamoyltransferase Mevan_1544 52 COG2192 COG2192, Predicted carbamoyl transferase, NodU family Posttranslational modification, protein turnover, chaperones 150399184 Nonpathogen - hypothetical protein Mevan_0431 1 COG4026 COG4026, Uncharacterized protein containing TOPRIM domain, potential nuclease General function prediction only 150398795 Common - Tetratricopeptide TPR_2 repeat protein Mevan_0035 143 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 150400061 Common - SirA family protein Mevan_1319 26 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 150398926 Common - cysteinyl-tRNA synthetase Mevan_0170 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150399473 Nonpathogen - 30S ribosomal protein S4e Mevan_0722 34 COG1471 RPS4A, Ribosomal protein S4E Translation, ribosomal structure and biogenesis 150399379 Nonpathogen - hypothetical protein Mevan_0628 1 None None None 150399369 Common - putative translaldolase Mevan_0618 168 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 150399716 Nonpathogen - flagellin Mevan_0968 9 COG1681 FlaB, Archaeal flagellins Cell motility and secretion 150399667 Common - phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase Mevan_0917 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 150399429 Common - 30S ribosomal protein S7P Mevan_0678 87 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 150400230 Nonpathogen - hypothetical protein Mevan_1491 5 COG4075 COG4075, Uncharacterized conserved protein, homolog of nitrogen regulatory protein PII Function unknown 150399312 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0560 35 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 150400048 Common - homoserine kinase Mevan_1306 122 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 150399041 Common - TPR repeat-containing protein Mevan_0287 139 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 150399033 Nonpathogen - hypothetical protein Mevan_0279 1 None None None 150399898 Nonpathogen - hypothetical protein Mevan_1155 25 COG2042 COG2042, Uncharacterized conserved protein Function unknown 150399588 Common - preprotein translocase subunit SecF Mevan_0837 76 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 150399143 Common - succinate dehydrogenase/fumarate reductase iron-sulfur subunit Mevan_0390 223 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 150400433 Common - hypothetical protein Mevan_1696 33 COG1340 COG1340, Uncharacterized archaeal coiled-coil protein Function unknown 150400356 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Mevan_1619 80 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 150399225 Common - NADH dehydrogenase (quinone) Mevan_0473 197 COG3261 HycE, Ni,Fe-hydrogenase III large subunit Energy production and conversion 150399603 Nonpathogen - hypothetical protein Mevan_0852 6 None None None 150399743 Nonpathogen - methylviologen-reducing hydrogenase, alpha subunit Mevan_0995 2 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 150400171 Nonpathogen - Dinitrogenase iron-molybdenum cofactor biosynthesis protein Mevan_1430 7 COG1433 COG1433, Uncharacterized conserved protein Function unknown 150399022 Nonpathogen - hypothetical protein Mevan_0268 1 None None None 150400241 Nonpathogen - transcriptional regulator, TrmB Mevan_1502 6 COG3355 COG3355, Predicted transcriptional regulator Transcription 150399003 Nonpathogen - hypothetical protein Mevan_0249 5 None None None 150399194 Common - protein of unknown function UPF0153 Mevan_0442 21 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 150399029 Common - NADPH-dependent FMN reductase Mevan_0275 40 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 150399495 Common - ribosomal protein L11 Mevan_0744 247 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 150400351 Common - protein of unknown function DUF1112 Mevan_1614 28 COG4760 COG4760, Predicted membrane protein Function unknown 150399812 Common - putative signal transduction protein with CBS domains Mevan_1067 151 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 150399441 Common - chlorohydrolase Mevan_0690 91 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 150399185 Nonpathogen - Ribonucleoprotein complex SRP, Srp19 component Mevan_0432 21 COG1400 SEC65, Signal recognition particle 19 kDa protein Intracellular trafficking and secretion 150399235 Common - CutA1 divalent ion tolerance protein Mevan_0483 84 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 150399911 Common - arsenite-activated ATPase ArsA Mevan_1168 95 COG0003 ArsA, Predicted ATPase involved in chromosome partitioning Cell division and chromosome partitioning 150399948 Nonpathogen - Protein of unknown function UPF0113 Mevan_1205 9 COG1374 NIP7, Protein involved in ribosomal biogenesis, contains PUA domain Translation, ribosomal structure and biogenesis 150399364 Common - integral membrane sensor signal transduction histidine kinase Mevan_0613 223 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 150400396 Nonpathogen - hypothetical protein Mevan_1659 1 None None None 150399687 Common - putative monovalent cation/H+ antiporter subunit C Mevan_0938 42 COG1006 MnhC, Multisubunit Na+/H+ antiporter, MnhC subunit Inorganic ion transport and metabolism 150398837 Nonpathogen - hypothetical protein Mevan_0078 6 COG1673 COG1673, Uncharacterized protein conserved in archaea Function unknown 150399537 Nonpathogen - hypothetical protein Mevan_0786 2 None None None 150399895 Nonpathogen - hypothetical protein Mevan_1151 4 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 150399820 Nonpathogen - Ribosomal LX protein Mevan_1075 9 COG2157 RPL20A, Ribosomal protein L20A (L18A) Translation, ribosomal structure and biogenesis 150398830 Common - NADH ubiquinone oxidoreductase 20 kDa subunit Mevan_0071 55 COG1941 FrhG, Coenzyme F420-reducing hydrogenase, gamma subunit Energy production and conversion 150399536 Nonpathogen - hypothetical protein Mevan_0785 1 None None None 150400210 Common - precorrin-6x reductase Mevan_1471 51 COG2099 CobK, Precorrin-6x reductase Coenzyme metabolism 150398791 Common - cobalt transport protein CbiM Mevan_0031 88 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 150398886 Common - transport system permease protein Mevan_0130 190 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 150400321 Common - UDP-glucose/GDP-mannose dehydrogenase Mevan_1584 207 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 150399794 Nonpathogen - type II secretion system protein Mevan_1048 3 COG1955 FlaJ, Archaeal flagella assembly protein J Cell motility and secretion / Intracellular trafficking and secretion 150400435 Common - Radical SAM domain protein Mevan_1698 88 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 150399624 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit D Mevan_0874 14 COG4060 MtrD, Tetrahydromethanopterin S-methyltransferase, subunit D Coenzyme metabolism 150399058 Nonpathogen - hypothetical protein Mevan_0304 3 COG1532 COG1532, Predicted RNA-binding protein General function prediction only 150399408 Nonpathogen - basic helix-loop-helix dimerization domain bHLH Mevan_0657 14 COG4002 COG4002, Predicted phosphotransacetylase General function prediction only 150399581 Common - peptidase M50 Mevan_0830 41 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 150399766 Nonpathogen - H(2)-dependent methylenetetrahydromethanopterin dehydrogenase-related protein Mevan_1018 6 COG4007 COG4007, Predicted dehydrogenase related to H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase General function prediction only 150399265 Common - ABC transporter related Mevan_0513 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 150399676 Common - putative translation initiation factor, aIF-2BI family Mevan_0927 131 COG0182 COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 150399319 Common - protein of unknown function DUF89 Mevan_0567 40 COG1578 COG1578, Uncharacterized conserved protein Function unknown 150400386 Nonpathogen - hypothetical protein Mevan_1649 1 None None None 150398973 Common - putative CheW protein Mevan_0218 132 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 150399086 Common - anthranilate phosphoribosyltransferase Mevan_0332 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 150400114 Common - uridylate kinase, putative Mevan_1372 248 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 150399245 Common - hypothetical protein Mevan_0493 22 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 150399410 Common - hypothetical protein Mevan_0659 213 COG1985 RibD, Pyrimidine reductase, riboflavin biosynthesis Coenzyme metabolism 150398989 Nonpathogen - hypothetical protein Mevan_0235 1 None None None 150398776 Common - Protein of unknown function DUF1867 Mevan_0016 20 COG1751 COG1751, Uncharacterized conserved protein Function unknown 150399936 Common - conserved hypothetical protein 374 Mevan_1193 13 COG0392 COG0392, Predicted integral membrane protein Function unknown 150400404 Common - molybdate ABC transporter, inner membrane subunit Mevan_1667 236 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 150399202 Common - RNA binding S1 domain protein Mevan_0450 216 COG2183 Tex, Transcriptional accessory protein Transcription 150398951 Common - glycosyl transferase family 2 Mevan_0196 125 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 150399924 Nonpathogen - hypothetical protein Mevan_1181 5 None None None 150398923 Nonpathogen - hypothetical protein Mevan_0167 1 None None None 150399207 Common - Malate/L-lactate dehydrogenase Mevan_0455 67 COG2055 COG2055, Malate/L-lactate dehydrogenases Energy production and conversion 150399555 Common - conserved hypothetical radical SAM protein Mevan_0804 88 COG1242 COG1242, Predicted Fe-S oxidoreductase General function prediction only 150399651 Common - carbamoyl phosphate synthase small subunit Mevan_0901 233 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 150398870 Nonpathogen - hypothetical protein Mevan_0112 2 None None None 150398998 Nonpathogen - Aldehyde ferredoxin oxidoreductase Mevan_0244 20 COG2414 COG2414, Aldehyde:ferredoxin oxidoreductase Energy production and conversion 150398825 Nonpathogen - hypothetical protein Mevan_0066 10 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 150399799 Nonpathogen - type II secretion system protein Mevan_1054 3 COG1955 FlaJ, Archaeal flagella assembly protein J Cell motility and secretion / Intracellular trafficking and secretion 150399292 Common - cobalt-precorrin-6Y C(5)-methyltransferase Mevan_0540 61 COG2241 CobL, Precorrin-6B methylase 1 Coenzyme metabolism 150400304 Common - iron dependent repressor Mevan_1567 112 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 150399955 Nonpathogen - DNA polymerase II small subunit Mevan_1212 24 COG1311 HYS2, Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B DNA replication, recombination, and repair 150399125 Nonpathogen - hypothetical protein Mevan_0371 4 COG2083 COG2083, Uncharacterized protein conserved in archaea Function unknown 150399251 Common - ABC transporter related Mevan_0499 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 150400041 Common - CBS domain containing protein Mevan_1299 90 COG4109 COG4109, Predicted transcriptional regulator containing CBS domains Transcription 150399434 Nonpathogen purP 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase Mevan_0683 20 COG1759 COG1759, ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases) General function prediction only 150400009 Common - carbohydrate kinase, YjeF related protein Mevan_1267 196 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 150400124 Nonpathogen - hypothetical protein Mevan_1382 2 None None None 150399275 Common - translation initiation factor IF-2 subunit gamma Mevan_0523 249 COG5257 GCD11, Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase) Translation, ribosomal structure and biogenesis 150399889 Common - (NiFe) hydrogenase maturation protein HypF Mevan_1145 113 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 150399546 Common - MscS Mechanosensitive ion channel Mevan_0795 193 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 150399595 Common - AIR synthase related protein Mevan_0844 47 COG2144 COG2144, Selenophosphate synthetase-related proteins General function prediction only 150400295 Nonpathogen - hypothetical protein Mevan_1558 1 None None None 150398982 Nonpathogen - CRISPR-associated protein Cas2 Mevan_0228 12 COG1343 COG1343, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 150400204 Nonpathogen - hypothetical protein Mevan_1465 4 None None None 150399468 Common - translation initiation factor Sui1 Mevan_0717 84 COG0023 SUI1, Translation initiation factor 1 (eIF-1/SUI1) and related proteins Translation, ribosomal structure and biogenesis 150399062 Common - Cobyrinic acid ac-diamide synthase Mevan_0308 118 COG3640 CooC, CO dehydrogenase maturation factor Cell division and chromosome partitioning 150399867 Nonpathogen - protein of unknown function DUF121 Mevan_1122 23 COG1920 COG1920, Uncharacterized conserved protein Function unknown 150400345 Common - elongation factor Tu domain 2 protein Mevan_1608 224 COG3276 SelB, Selenocysteine-specific translation elongation factor Translation, ribosomal structure and biogenesis 150399565 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Mevan_0814 134 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 150399510 Nonpathogen - hypothetical protein Mevan_0759 2 COG4042 COG4042, Predicted membrane protein Function unknown 150399882 Common - branched-chain amino acid aminotransferase Mevan_1137 215 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 150399055 Common - putative molybdenum ABC transporter, solute-binding protein Mevan_0301 71 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 150399680 Common - NADH ubiquinone oxidoreductase 20 kDa subunit Mevan_0931 192 COG3260 COG3260, Ni,Fe-hydrogenase III small subunit Energy production and conversion 150399302 Nonpathogen - hypothetical protein Mevan_0550 25 COG2122 COG2122, Uncharacterized conserved protein Function unknown 150398948 Common - protein of unknown function DUF58 Mevan_0193 18 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 150400015 Common rpl1P 50S ribosomal protein L1P Mevan_1273 237 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 150399863 Nonpathogen - hypothetical protein Mevan_1118 2 None None None 150399423 Common - DNA-directed RNA polymerase subunit B' Mevan_0672 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 150399684 Common - putative monovalent cation/H+ antiporter subunit B Mevan_0935 55 COG2111 MnhB, Multisubunit Na+/H+ antiporter, MnhB subunit Inorganic ion transport and metabolism 150400075 Common - replication factor C large subunit Mevan_1333 173 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 150399295 Nonpathogen - DNA polymerase beta domain protein region Mevan_0543 18 COG1665 COG1665, Uncharacterized protein conserved in archaea Function unknown 150399012 Common - CheC, inhibitor of MCP methylation Mevan_0258 6 COG1776 CheC, Chemotaxis protein CheC, inhibitor of MCP methylation Cell motility and secretion / Signal transduction mechanisms 150398808 Common - porphobilinogen deaminase Mevan_0048 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 150398841 Common - type I site-specific deoxyribonuclease, HsdR family Mevan_0082 137 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 150398916 Common - hypothetical protein Mevan_0160 3 None None None 150399258 Common - peptidylprolyl isomerase FKBP-type Mevan_0506 136 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 150399210 Common - Rubrerythrin Mevan_0458 30 COG1592 COG1592, Rubrerythrin Energy production and conversion 150399286 Common - helicase c2 Mevan_0534 131 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 150399996 Nonpathogen - hypothetical protein Mevan_1254 7 COG5306 COG5306, Uncharacterized conserved protein Function unknown 150400333 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_1596 29 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 150400417 Nonpathogen - hypothetical protein Mevan_1680 1 None None None 150399939 Nonpathogen - DNA polymerase II large subunit Mevan_1196 25 COG1933 COG1933, Archaeal DNA polymerase II, large subunit DNA replication, recombination, and repair 150399067 Common ksgA dimethyladenosine transferase Mevan_0313 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 150399166 Common - UDP-glucose 6-dehydrogenase Mevan_0413 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 150400229 Common radB DNA repair and recombination protein RadB Mevan_1490 31 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 150399017 Common - N-6 DNA methylase Mevan_0263 147 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 150398873 Nonpathogen - CRISPR-associated protein Cas2 Mevan_0115 6 COG1343 COG1343, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 150400068 Common - indolepyruvate oxidoreductase subunit B Mevan_1326 77 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 150398848 Common - Tetratricopeptide TPR_2 repeat protein Mevan_0089 102 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 150399669 Nonpathogen - hypothetical protein Mevan_0920 2 None None None 150400046 Common - aldolase Mevan_1304 77 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 150399835 Common - Radical SAM domain protein Mevan_1090 91 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 150400222 Nonpathogen - beta-lactamase domain protein Mevan_1483 4 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 150399482 Nonpathogen rpl30p 50S ribosomal protein L30P Mevan_0731 34 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 150400325 Common - thiamine pyrophosphate protein domain protein TPP-binding Mevan_1588 113 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 150399648 Nonpathogen - hypothetical protein Mevan_0898 2 None None None 150399327 Nonpathogen - hypothetical protein Mevan_0575 2 None None None 150398770 Common - NADPH-dependent FMN reductase Mevan_0010 108 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 150400235 Common - protein of unknown function DUF124 Mevan_1496 38 COG2013 COG2013, Uncharacterized conserved protein Function unknown 150399732 Common - metallophosphoesterase Mevan_0984 33 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 150400195 Common valS valyl-tRNA synthetase Mevan_1456 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150399419 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0668 77 COG2768 COG2768, Uncharacterized Fe-S center protein General function prediction only 150400248 Common - signal recognition particle-docking protein FtsY Mevan_1509 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 150399750 Common - SSS sodium solute transporter superfamily Mevan_1002 166 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 150400156 Nonpathogen - Ribonuclease P Mevan_1415 17 COG1603 RPP1, RNase P/RNase MRP subunit p30 Translation, ribosomal structure and biogenesis 150399096 Common - Radical SAM domain protein Mevan_0342 28 COG1244 COG1244, Predicted Fe-S oxidoreductase General function prediction only 150398938 Common - ornithine carbamoyltransferase Mevan_0182 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 150398780 Common - small GTP-binding protein Mevan_0020 174 COG1084 COG1084, Predicted GTPase General function prediction only 150399464 Nonpathogen - hypothetical protein Mevan_0713 1 None None None 150400137 Common - CBS domain containing protein Mevan_1395 171 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 150399347 Nonpathogen - DNA primase Mevan_0596 34 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 150399173 Common - phosphate binding protein Mevan_0420 145 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 150399854 Common - putative transcriptional regulator, XRE family Mevan_1109 84 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 150398900 Common - putative PAS/PAC sensor protein Mevan_0144 106 COG2202 AtoS, FOG: PAS/PAC domain Signal transduction mechanisms 150399986 Common - cysteine-rich small domain Mevan_1244 16 COG2158 COG2158, Uncharacterized protein containing a Zn-finger-like domain General function prediction only 150400432 Common - phosphoserine phosphatase SerB Mevan_1695 159 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 150400267 Nonpathogen - hypothetical protein Mevan_1528 1 None None None 150399374 Nonpathogen - flap endonuclease-1 Mevan_0623 34 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 150399290 Nonpathogen - hypothetical protein Mevan_0538 14 COG4065 COG4065, Uncharacterized protein conserved in archaea Function unknown 150399886 Common - 3-isopropylmalate dehydratase, small subunit Mevan_1141 213 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 150400220 Nonpathogen - peptidyl-tRNA hydrolase Mevan_1481 34 COG1990 COG1990, Uncharacterized conserved protein Function unknown 150400378 Nonpathogen - hypothetical protein Mevan_1641 1 None None None 150399453 Common - aspartate-semialdehyde dehydrogenase Mevan_0702 211 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 150398865 Common - CRISPR-associated TM1793 family protein Mevan_0107 3 COG1769 COG1769, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 150399394 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Mevan_0643 208 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 150398897 Nonpathogen - hypothetical protein Mevan_0141 1 None None None 150398816 Nonpathogen - putative signal transduction protein with CBS domains Mevan_0057 6 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 150398881 Common - von Willebrand factor type A Mevan_0124 62 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 150400413 Common - protein of unknown function DUF214 Mevan_1676 163 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 150400266 Nonpathogen - protein of unknown function DUF125 transmembrane Mevan_1527 5 COG1814 COG1814, Uncharacterized membrane protein Function unknown 150399959 Nonpathogen - hypothetical protein Mevan_1216 1 None None None 150399458 Common - aminotransferase Mevan_0707 230 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 150399577 Common - Variant SH3 domain protein Mevan_0826 8 None None None 150400023 Common - hypothetical protein Mevan_1281 64 COG1641 COG1641, Uncharacterized conserved protein Function unknown 150399529 Nonpathogen - Helix-turn-helix type 11 domain protein Mevan_0778 3 None None None 150399522 Nonpathogen - (NiFe)-hydrogenase-3-type complex Eha, EhaM Mevan_0771 4 COG4084 COG4084, Uncharacterized protein conserved in archaea Function unknown 150399384 Common - RNA polymerase insert Mevan_0633 36 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 150399445 Common - NADH ubiquinone oxidoreductase 20 kDa subunit Mevan_0694 89 COG1941 FrhG, Coenzyme F420-reducing hydrogenase, gamma subunit Energy production and conversion 150398797 Nonpathogen - hypothetical protein Mevan_0037 2 None None None 150400341 Common - MATE efflux family protein Mevan_1604 75 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 150399387 Nonpathogen rps9p 30S ribosomal protein S9P Mevan_0636 34 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 150399479 Nonpathogen rpl19e 50S ribosomal protein L19e Mevan_0728 34 COG2147 RPL19A, Ribosomal protein L19E Translation, ribosomal structure and biogenesis 150400381 Nonpathogen - hypothetical protein Mevan_1644 3 None None None 150399528 Common - putative signal transduction protein with CBS domains Mevan_0777 56 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 150399024 Common - transcriptional regulator, TetR family Mevan_0270 138 COG1309 AcrR, Transcriptional regulator Transcription 150399132 Nonpathogen - protein of unknown function DUF167 Mevan_0378 12 COG1872 COG1872, Uncharacterized conserved protein Function unknown 150399757 Common - translation initiation factor IF-2 subunit alpha Mevan_1009 220 COG1093 SUI2, Translation initiation factor 2, alpha subunit (eIF-2alpha) Translation, ribosomal structure and biogenesis 150399420 Common - protein of unknown function DUF39 Mevan_0669 127 COG1900 COG1900, Uncharacterized conserved protein Function unknown 150400010 Common - PHP domain protein Mevan_1268 38 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 150399056 Nonpathogen - Protein of unknown function DUF166 Mevan_0302 9 COG1810 COG1810, Uncharacterized protein conserved in archaea Function unknown 150400425 Nonpathogen - HEPN domain protein Mevan_1688 1 COG1895 COG1895, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 150398942 Nonpathogen - hypothetical protein Mevan_0186 5 None None None 150400355 Common - NifC-like ABC-type porter Mevan_1618 213 COG0555 CysU, ABC-type sulfate transport system, permease component Posttranslational modification, protein turnover, chaperones 150398890 Nonpathogen - hypothetical protein Mevan_0134 1 None None None 150400122 Common - phosphodiesterase, MJ0936 family Mevan_1380 58 COG0622 COG0622, Predicted phosphoesterase General function prediction only 150399111 Common - dTMP kinase Mevan_0357 181 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 150399356 Common - glucose-6-phosphate isomerase Mevan_0605 210 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 150399196 Common - integral membrane sensor signal transduction histidine kinase Mevan_0444 223 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 150399568 Common - protein of unknown function DUF161 Mevan_0817 59 COG1284 COG1284, Uncharacterized conserved protein Function unknown 150399636 Common - 8-amino-7-oxononanoate synthase Mevan_0886 190 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 150400097 Common - phosphate binding protein Mevan_1355 129 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 150399035 Common - cation diffusion facilitator family transporter Mevan_0281 20 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 150400080 Common - thymidine phosphorylase Mevan_1338 144 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 150399223 Common - homoaconitate hydratase family protein Mevan_0471 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 150399978 Nonpathogen - hypothetical protein Mevan_1236 3 None None None 150399932 Common - thiamine biosynthesis protein ThiC Mevan_1189 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 150399154 Common - hypothetical protein Mevan_0401 8 None None None 150399670 Nonpathogen - protein of unknown function DUF75 Mevan_0921 32 COG2047 COG2047, Uncharacterized protein (ATP-grasp superfamily) General function prediction only 150399707 Common pyrB aspartate carbamoyltransferase catalytic subunit Mevan_0959 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 150398761 Common - flavin reductase domain protein FMN-binding Mevan_0001 77 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 150399778 Common - regulatory protein ArsR Mevan_1030 10 COG1474 CDC6, Cdc6-related protein, AAA superfamily ATPase DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones 150400358 Nonpathogen - hypothetical protein Mevan_1621 1 None None None 150400215 Common - Non-specific serine/threonine protein kinase Mevan_1476 66 COG1718 RIO1, Serine/threonine protein kinase involved in cell cycle control Signal transduction mechanisms / Cell division and chromosome partitioning 150399722 Common - flagellar accessory protein FlaH Mevan_0974 21 COG2874 FlaH, Predicted ATPases involved in biogenesis of archaeal flagella Cell motility and secretion / Intracellular trafficking and secretion 150400271 Common - Radical SAM domain protein Mevan_1533 72 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 150399627 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit A Mevan_0877 17 COG4063 MtrA, Tetrahydromethanopterin S-methyltransferase, subunit A Coenzyme metabolism 150400310 Common - Proteasome endopeptidase complex Mevan_1573 48 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 150400019 Common - MscS Mechanosensitive ion channel Mevan_1277 195 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 150399784 Nonpathogen - type II secretion system protein Mevan_1036 3 COG1955 FlaJ, Archaeal flagella assembly protein J Cell motility and secretion / Intracellular trafficking and secretion 150399703 Common - hypothetical protein Mevan_0955 5 None None None 150398953 Common - UDP-N-acetylglucosamine 2-epimerase Mevan_0198 153 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 150399088 Common - hypothetical protein Mevan_0334 13 COG3815 COG3815, Predicted membrane protein Function unknown 150399069 Common - DNA topoisomerase VI subunit B Mevan_0315 34 COG1389 COG1389, DNA topoisomerase VI, subunit B DNA replication, recombination, and repair 150400131 Common - hypothetical protein Mevan_1389 20 COG2512 COG2512, Uncharacterized membrane-associated protein/domain Function unknown 150399333 Nonpathogen - Domain of unkown function DUF1786 putative pyruvate format-lyase activating enzyme Mevan_0581 12 COG4012 COG4012, Uncharacterized protein conserved in archaea Function unknown 150399137 Common - hypothetical protein Mevan_0384 84 COG1750 COG1750, Archaeal serine proteases General function prediction only 150398949 Nonpathogen - hypothetical protein Mevan_0194 1 None None None 150399610 Common rpl2p 50S ribosomal protein L2P Mevan_0860 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 150399802 Nonpathogen - H/ACA RNA-protein complex component Gar1 Mevan_1057 2 COG3277 GAR1, RNA-binding protein involved in rRNA processing Translation, ribosomal structure and biogenesis 150399101 Common - (R)-citramalate synthase Mevan_0347 223 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 150399021 Common - MCM family protein Mevan_0267 51 COG1241 MCM2, Predicted ATPase involved in replication control, Cdc46/Mcm family DNA replication, recombination, and repair 150398965 Nonpathogen - hypothetical protein Mevan_0210 1 None None None 150399718 Nonpathogen - flagella protein Mevan_0970 9 COG3351 FlaD, Putative archaeal flagellar protein D/E Cell motility and secretion 150399711 Common - protein of unknown function DUF521 Mevan_0963 39 COG1679 COG1679, Uncharacterized conserved protein Function unknown 150398960 Common - Glutamine--scyllo-inositol transaminase Mevan_0205 194 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 150399720 Nonpathogen - flagella protein F Mevan_0972 2 COG3353 FlaF, Putative archaeal flagellar protein F Cell motility and secretion 150400347 Nonpathogen - hypothetical protein Mevan_1610 1 None None None 150399764 Common - Roadblock/LC7 family protein Mevan_1016 26 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 150400318 Common - protein of unknown function DUF752 Mevan_1581 28 COG4121 COG4121, Uncharacterized conserved protein Function unknown 150400159 Common - putative flavodoxin Mevan_1418 23 COG0716 FldA, Flavodoxins Energy production and conversion 150400085 Common - protein of unknown function DUF92 transmembrane Mevan_1343 48 COG1836 COG1836, Predicted membrane protein Function unknown 150399476 Common rps8p 30S ribosomal protein S8P Mevan_0725 225 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 150399583 Common - binding-protein-dependent transport systems inner membrane component Mevan_0832 228 COG0555 CysU, ABC-type sulfate transport system, permease component Posttranslational modification, protein turnover, chaperones 150398839 Common - restriction modification system DNA specificity domain Mevan_0080 35 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 150399243 Common - CDP-diacylglycerol--serine O-phosphatidyltransferase Mevan_0491 152 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 150399436 Common - tRNA methyltransferase complex GCD14 subunit Mevan_0685 61 COG2519 GCD14, tRNA(1-methyladenosine) methyltransferase and related methyltransferases Translation, ribosomal structure and biogenesis 150399629 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit G Mevan_0879 14 COG4064 MtrG, Tetrahydromethanopterin S-methyltransferase, subunit G Coenzyme metabolism 150399053 Common - permease Mevan_0299 80 COG0701 COG0701, Predicted permeases General function prediction only 150400168 Nonpathogen - Protein of unknown function DUF359 Mevan_1427 30 COG1909 COG1909, Uncharacterized protein conserved in archaea Function unknown 150399446 Common - coenzyme F420-reducing hydrogenase subunit beta Mevan_0695 36 COG1035 FrhB, Coenzyme F420-reducing hydrogenase, beta subunit Energy production and conversion 150398928 Common - homoserine O-acetyltransferase Mevan_0172 201 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 150399461 Common - aspartate/glutamate/uridylate kinase Mevan_0710 28 COG2054 COG2054, Uncharacterized archaeal kinase related to aspartokinases, uridylate kinases General function prediction only 150399934 Nonpathogen - FeoA family protein Mevan_1191 2 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 150399070 Nonpathogen - hypothetical protein Mevan_0316 28 COG1650 COG1650, Uncharacterized protein conserved in archaea Function unknown 150399157 Common - glycosyl transferase family 2 Mevan_0404 176 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 150400112 Nonpathogen - S-layer protein Mevan_1370 3 None None None 150399612 Common - hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit Mevan_0862 143 COG1838 FumA, Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain Energy production and conversion 150400173 Common - hypothetical protein Mevan_1433 27 COG1433 COG1433, Uncharacterized conserved protein Function unknown 150399826 Common - nitrogen regulatory protein P-II Mevan_1081 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 150400004 Nonpathogen rpl37ae 50S ribosomal protein L37Ae Mevan_1262 34 COG1997 RPL43A, Ribosomal protein L37AE/L43A Translation, ribosomal structure and biogenesis 150399256 Nonpathogen - hypothetical protein Mevan_0504 26 COG1698 COG1698, Uncharacterized protein conserved in archaea Function unknown 150398820 Common - Nitrogenase Mevan_0061 57 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 150398774 Nonpathogen - transcriptional regulator, TrmB Mevan_0014 11 COG3355 COG3355, Predicted transcriptional regulator Transcription 150398991 Common - translation initiation factor IF-5A Mevan_0237 41 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 150399081 Common trpA tryptophan synthase subunit alpha Mevan_0327 218 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 150399240 Common - ABC transporter related Mevan_0488 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 150399401 Common - protein of unknown function DUF890 Mevan_0650 82 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 150399848 Nonpathogen - Protein of unknown function DUF655 Mevan_1103 33 COG1491 COG1491, Predicted RNA-binding protein Translation, ribosomal structure and biogenesis 150399497 Nonpathogen secE preprotein translocase subunit SecE Mevan_0746 2 COG2443 Sss1, Preprotein translocase subunit Sss1 Intracellular trafficking and secretion 150399539 Nonpathogen - protein of unknown function DUF147 Mevan_0788 25 COG1624 COG1624, Uncharacterized conserved protein Function unknown 150399512 Nonpathogen - hypothetical protein Mevan_0761 4 COG4040 COG4040, Predicted membrane protein Function unknown 150399233 Nonpathogen - hypothetical protein Mevan_0481 8 None None None 150399491 Nonpathogen - transcription termination factor Tfs Mevan_0740 33 COG1594 RPB9, DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS Transcription 150399406 Nonpathogen - hypothetical protein Mevan_0655 1 None None None 150399862 Common - phosphonopyruvate decarboxylase-related protein Mevan_1117 51 COG3635 COG3635, Predicted phosphoglycerate mutase, AP superfamily Carbohydrate transport and metabolism 150399963 Nonpathogen - hypothetical protein Mevan_1220 2 COG4014 COG4014, Uncharacterized protein conserved in archaea Function unknown 150399498 Common - cell division protein FtsZ Mevan_0747 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 150399941 Common - protein of unknown function DUF114 Mevan_1198 43 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 150399187 Nonpathogen - hypothetical protein Mevan_0435 5 COG1822 COG1822, Predicted archaeal membrane protein Function unknown 150400056 Nonpathogen - N-glycosylase/DNA lyase Mevan_1314 12 COG4047 COG4047, Uncharacterized protein conserved in archaea Function unknown 150399657 Nonpathogen - PUA domain containing protein Mevan_0907 22 COG1549 COG1549, Queuine tRNA-ribosyltransferases, contain PUA domain Translation, ribosomal structure and biogenesis 150400398 Nonpathogen - formylmethanofuran dehydrogenase subunit E region Mevan_1661 13 COG2191 COG2191, Formylmethanofuran dehydrogenase subunit E Energy production and conversion 150399845 Common hemA glutamyl-tRNA reductase Mevan_1100 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 150399454 Common - protein of unknown function UPF0027 Mevan_0703 120 COG1690 RtcB, Uncharacterized conserved protein Function unknown 150398793 Common - Stress responsive alpha-beta barrel domain protein Mevan_0033 29 None None None 150399913 Common - daunorubicin resistance ABC transporter, inner membrane subunit B Mevan_1170 204 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 150399544 Common - cobalt ABC transporter, ATPase subunit Mevan_0793 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 150400017 Nonpathogen - hypothetical protein Mevan_1275 2 COG3286 COG3286, Uncharacterized protein conserved in archaea Function unknown 150399417 Common - PP-loop domain protein Mevan_0666 127 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 150399197 Common - translation-associated GTPase Mevan_0445 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 150399263 Nonpathogen - hypothetical protein Mevan_0511 2 None None None 150399642 Common - dihydropteroate synthase-related protein Mevan_0892 33 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 150400190 Common - chorismate mutase Mevan_1451 20 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 150400202 Nonpathogen - hypothetical protein Mevan_1463 1 None None None 150399324 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Mevan_0572 245 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 150399658 Nonpathogen - protein of unknown function DUF95 transmembrane Mevan_0908 9 COG1300 SpoIIM, Uncharacterized membrane protein Function unknown 150399698 Common - aspartate/glutamate/uridylate kinase Mevan_0950 40 COG1608 COG1608, Predicted archaeal kinase General function prediction only 150399682 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0933 107 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 150398832 Common - nickel-dependent hydrogenase large subunit Mevan_0073 105 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 150399579 Common - thermosome Mevan_0828 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 150400033 Common - phosphoribosyl-AMP cyclohydrolase Mevan_1291 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 150399425 Common - DNA-directed RNA polymerase subunit A'' Mevan_0674 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 150399600 Nonpathogen - nucleic acid binding OB-fold tRNA/helicase-type Mevan_0849 2 COG4085 COG4085, Predicted RNA-binding protein, contains TRAM domain General function prediction only 150398818 Common - Nitrogenase Mevan_0059 59 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 150399065 Nonpathogen - acetyl-CoA decarbonylase/synthase complex subunit alpha Mevan_0311 13 COG1152 CdhA, CO dehydrogenase/acetyl-CoA synthase alpha subunit Energy production and conversion 150399560 Common - cell division protein FtsZ Mevan_0809 233 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 150398803 Common - nicotinate-nucleotide pyrophosphorylase Mevan_0043 203 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 150399212 Common - hydroxyethylthiazole kinase Mevan_0460 77 COG2145 ThiM, Hydroxyethylthiazole kinase, sugar kinase family Coenzyme metabolism 150399517 Common - putative transmembrane subunit of a hydrogenase Mevan_0766 16 COG4078 COG4078, Predicted membrane protein Function unknown 150399553 Nonpathogen - S-layer protein Mevan_0802 3 None None None 150399906 Nonpathogen - ExsB family protein Mevan_1163 19 COG2117 COG2117, Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 150400095 Common - putative ATP binding protein Mevan_1353 43 COG2102 COG2102, Predicted ATPases of PP-loop superfamily General function prediction only 150400330 Nonpathogen - hypothetical protein Mevan_1593 1 None None None 150399146 Nonpathogen - hypothetical protein Mevan_0393 2 COG1241 MCM2, Predicted ATPase involved in replication control, Cdc46/Mcm family DNA replication, recombination, and repair 150398871 Nonpathogen - hypothetical protein Mevan_0113 5 None None None 150399922 Nonpathogen - hypothetical protein Mevan_1179 1 None None None 150400339 Common - exodeoxyribonuclease VII small subunit Mevan_1602 2 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 150399803 Common - isopentenyl pyrophosphate isomerase Mevan_1058 86 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 150400306 Common - ferrous iron transport protein B Mevan_1569 193 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 150399484 Common - preprotein translocase subunit SecY Mevan_0733 51 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 150400187 Nonpathogen gatC aspartyl/glutamyl-tRNA amidotransferase subunit C Mevan_1448 2 None None None 150399366 Common - domain of unknown function DUF1745 Mevan_0615 12 COG3287 COG3287, Uncharacterized conserved protein Function unknown 150399019 Common - type III restriction protein res subunit Mevan_0265 130 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 150399376 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit gamma Mevan_0625 69 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 150399781 Nonpathogen - transcription initiation factor E subunit alpha Mevan_1033 32 COG1675 TFA1, Transcription initiation factor IIE, alpha subunit Transcription 150398827 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0068 45 COG1148 HdrA, Heterodisulfide reductase, subunit A and related polyferredoxins Energy production and conversion 150400419 Nonpathogen - hypothetical protein Mevan_1682 1 None None None 150399217 Common - Tetratricopeptide TPR_2 repeat protein Mevan_0465 17 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 150398935 Nonpathogen - hypothetical protein Mevan_0179 7 COG4744 COG4744, Uncharacterized conserved protein Function unknown 150399609 Common rplW 50S ribosomal protein L23 Mevan_0859 139 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 150399593 Common - Methyltransferase type 11 Mevan_0842 9 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 150400297 Common - regulatory protein ArsR Mevan_1560 11 COG0640 ArsR, Predicted transcriptional regulators Transcription 150399639 Common - histone acetyltransferase, ELP3 family Mevan_0889 99 COG1243 ELP3, Histone acetyltransferase Transcription / Chromatin structure and dynamics 150399792 Nonpathogen - H/ACA RNA-protein complex component Gar1 Mevan_1045 2 COG3277 GAR1, RNA-binding protein involved in rRNA processing Translation, ribosomal structure and biogenesis 150399209 Common - flavodoxin/nitric oxide synthase Mevan_0457 79 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 150400402 Common - molybdenum cofactor synthesis domain Mevan_1665 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 150399273 Common - glutamine synthetase, type I Mevan_0521 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 150399691 Common - Radical SAM domain protein Mevan_0943 40 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 150400200 Common - glycosyl transferase family 2 Mevan_1461 138 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 150399091 Common - pseudouridine synthase, RluA family Mevan_0337 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 150400423 Common - sulfate transporter Mevan_1686 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 150400298 Nonpathogen - hypothetical protein Mevan_1561 5 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 150399584 Common - hydrogenase accessory protein HypB Mevan_0833 152 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 150398992 Common - cobalamin biosynthesis protein CobD Mevan_0238 148 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 150399694 Common - Haloacid dehalogenase domain protein hydrolase Mevan_0946 142 COG4087 COG4087, Soluble P-type ATPase General function prediction only 150400073 Nonpathogen - shikimate kinase Mevan_1331 25 COG1685 COG1685, Archaeal shikimate kinase Amino acid transport and metabolism / Coenzyme metabolism 150400071 Common - dihydroxy-acid dehydratase Mevan_1329 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 150399080 Nonpathogen - Protein of unknown function DUF650 Mevan_0326 32 COG1602 COG1602, Uncharacterized conserved protein Function unknown 150398968 Common - S-adenosyl-L-homocysteine hydrolase Mevan_0213 177 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 150398821 Common - nitrogenase alpha chain Mevan_0062 57 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 150400209 Common - Phosphoglycerate mutase Mevan_1470 47 COG3635 COG3635, Predicted phosphoglycerate mutase, AP superfamily Carbohydrate transport and metabolism 150398828 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0069 109 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 150399809 Common - carbonic anhydrase (gamma family Zn(II)-dependent enzyme) Mevan_1064 215 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 150399926 Common - Phosphoribosylformylglycinamidine synthase Mevan_1183 233 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 150398956 Common - glycosyl transferase group 1 Mevan_0201 175 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 150399618 Nonpathogen - Coenzyme-B sulfoethylthiotransferase Mevan_0868 14 COG4054 McrB, Methyl coenzyme M reductase, beta subunit Coenzyme metabolism 150399928 Common - 3,4-dihydroxy-2-butanone 4-phosphate synthase Mevan_1185 228 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 150398806 Common - Methyltransferase type 12 Mevan_0046 45 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 150398971 Common - dihydrodipicolinate reductase Mevan_0216 217 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 150398922 Nonpathogen - hypothetical protein Mevan_0166 8 COG2373 COG2373, Large extracellular alpha-helical protein General function prediction only 150400011 Common hisH imidazole glycerol phosphate synthase subunit HisH Mevan_1269 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 150399800 Common - type II secretion system protein E Mevan_1055 223 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 150400415 Common - ABC transporter related Mevan_1678 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 150399282 Common - cobyric acid synthase Mevan_0530 152 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 150399296 Common - modD protein Mevan_0544 201 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 150399272 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Mevan_0520 239 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 150399688 Common - ABC transporter related Mevan_0939 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 150399172 Common - phosphoenolpyruvate synthase Mevan_0419 236 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 150399662 Common - alpha-L-glutamate ligase, RimK family Mevan_0912 136 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 150399432 Common rps10p 30S ribosomal protein S10P Mevan_0681 244 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 150400407 Nonpathogen - hypothetical protein Mevan_1670 20 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 150400031 Common - putative signal transduction protein with CBS domains Mevan_1289 155 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 150400179 Common - protein of unknown function DUF201 Mevan_1440 19 COG1821 COG1821, Predicted ATP-utilizing enzyme (ATP-grasp superfamily) General function prediction only 150399149 Nonpathogen - putative monovalent cation/H+ antiporter subunit G Mevan_0396 5 COG1320 MnhG, Multisubunit Na+/H+ antiporter, MnhG subunit Inorganic ion transport and metabolism 150399106 Nonpathogen - hypothetical protein Mevan_0352 3 None None None 150399672 Nonpathogen - chromatin protein Mevan_0923 28 COG1581 Ssh10b, Archaeal DNA-binding protein Transcription 150400093 Common - pyruvate carboxylase subunit A Mevan_1351 238 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 150399944 Common - nickel responsive regulator Mevan_1201 66 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 150400144 Common - threonyl-tRNA synthetase Mevan_1403 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150399950 Common truD tRNA pseudouridine synthase D Mevan_1207 90 COG0585 COG0585, Uncharacterized conserved protein Function unknown 150400193 Common - magnesium transporter Mevan_1454 170 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 150399930 Common - purine phosphorylase family 2 Mevan_1187 165 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 150398833 Common - coenzyme F420-reducing hydrogenase delta subunit Mevan_0074 33 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 150399561 Common - phosphodiesterase, MJ0936 family Mevan_0810 73 COG0622 COG0622, Predicted phosphoesterase General function prediction only 150399994 Nonpathogen - hypothetical protein Mevan_1252 5 COG5306 COG5306, Uncharacterized conserved protein Function unknown 150399470 Common rps17p 30S ribosomal protein S17P Mevan_0719 59 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 150399189 Nonpathogen - hypothetical protein Mevan_0437 3 None None None 150399438 Nonpathogen - hypothetical protein Mevan_0687 6 COG1800 COG1800, Predicted transglutaminase-like proteases General function prediction only 150399991 Nonpathogen - Protein of unknown function DUF361 Mevan_1249 2 COG1991 COG1991, Uncharacterized conserved protein Function unknown 150399485 Common - glycosyl transferase family 4 Mevan_0734 76 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 150399679 Common - energy conserving hydrogenase B integral membrane subunit Mevan_0930 10 COG0650 HyfC, Formate hydrogenlyase subunit 4 Energy production and conversion 150400119 Common - protein of unknown function DUF84 Mevan_1377 38 COG1986 COG1986, Uncharacterized conserved protein Function unknown 150400213 Common - orotidine 5'-phosphate decarboxylase Mevan_1474 113 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 150399051 Common - hypothetical protein Mevan_0297 66 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 150400288 Nonpathogen - hypothetical protein Mevan_1551 13 COG4020 COG4020, Uncharacterized protein conserved in archaea Function unknown 150400371 Common - phage integrase family protein Mevan_1634 216 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 150399533 Nonpathogen - hypothetical protein Mevan_0782 19 COG1458 COG1458, Predicted DNA-binding protein containing PIN domain General function prediction only 150399846 Common - siroheme synthase Mevan_1101 64 COG1648 CysG, Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) Coenzyme metabolism 150399543 Common - cobalt ABC transporter, inner membrane subunit CbiQ Mevan_0792 53 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 150400293 Common - glutamate dehydrogenase Mevan_1556 169 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 150399045 Common hisD histidinol dehydrogenase Mevan_0291 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 150399277 Nonpathogen - helix-turn-helix domain protein Mevan_0525 29 COG1709 COG1709, Predicted transcriptional regulator Transcription 150399232 Common - hypothetical protein Mevan_0480 4 COG1773 COG1773, Rubredoxin Energy production and conversion 150400007 Nonpathogen - hypothetical protein Mevan_1265 1 None None None 150399914 Common - MATE efflux family protein Mevan_1171 159 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 150399530 Nonpathogen - putative monovalent cation/H+ antiporter subunit E Mevan_0779 18 COG1863 MnhE, Multisubunit Na+/H+ antiporter, MnhE subunit Inorganic ion transport and metabolism 150399443 Common - nickel-dependent hydrogenase large subunit Mevan_0692 107 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 150399268 Common - nuclease (SNase domain protein) Mevan_0516 38 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 150399798 Nonpathogen - hypothetical protein Mevan_1053 3 None None None 150399571 Common - extracellular solute-binding protein family 3 Mevan_0820 149 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 150399816 Common - FO synthase subunit 2 Mevan_1071 88 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 150400256 Common - transcriptional regulator, XRE family Mevan_1517 67 COG1476 COG1476, Predicted transcriptional regulators Transcription 150400253 Common - hypothetical protein Mevan_1514 33 COG1395 COG1395, Predicted transcriptional regulator Transcription 150400163 Common - glutamate--cysteine ligase GCS2 Mevan_1422 9 COG2170 COG2170, Uncharacterized conserved protein Function unknown 150399404 Nonpathogen - Nucleotide binding protein PINc Mevan_0653 11 COG1412 COG1412, Uncharacterized proteins of PilT N-term./Vapc superfamily General function prediction only 150399349 Common - UbiD family decarboxylase Mevan_0598 151 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 150399124 Nonpathogen - Protein of unknown function DUF22 Mevan_0370 5 COG1417 COG1417, Uncharacterized conserved protein Function unknown 150400198 Nonpathogen - diphthine synthase Mevan_1459 34 COG1798 DPH5, Diphthamide biosynthesis methyltransferase Translation, ribosomal structure and biogenesis 150400000 Nonpathogen - prefoldin, beta subunit Mevan_1258 25 COG1382 GimC, Prefoldin, chaperonin cofactor Posttranslational modification, protein turnover, chaperones 150400382 Nonpathogen - hypothetical protein Mevan_1645 2 None None None 150400368 Nonpathogen - hypothetical protein Mevan_1631 2 None None None 150400058 Common - 2-oxoacid ferredoxin oxidoreductase subunit beta Mevan_1316 110 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 150398783 Common argJ bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein Mevan_0023 167 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 150400052 Common - N-6 DNA methylase Mevan_1310 79 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 150399769 Common - hypothetical protein Mevan_1021 4 None None None 150399255 Common - class II aldolase/adducin family protein Mevan_0503 158 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 150398906 Nonpathogen - hypothetical protein Mevan_0150 2 None None None 150398917 Nonpathogen - hypothetical protein Mevan_0161 1 None None None 150399098 Common - diaminopimelate dehydrogenase Mevan_0344 16 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 150399160 Nonpathogen - HpcH/HpaI aldolase Mevan_0407 5 COG3836 HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase Carbohydrate transport and metabolism 150400099 Common - GPR1/FUN34/yaaH family protein Mevan_1357 51 COG1584 COG1584, Predicted membrane protein Function unknown 150400342 Nonpathogen - hypothetical protein Mevan_1605 1 None None None 150400110 Common - 3-isopropylmalate dehydratase, small subunit Mevan_1368 220 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 150399242 Common - glycosyl transferase family 2 Mevan_0490 173 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 150398910 Common - Site-specific DNA-methyltransferase (adenine-specific) Mevan_0154 94 COG2189 COG2189, Adenine specific DNA methylase Mod DNA replication, recombination, and repair 150399249 Common - periplasmic binding protein Mevan_0497 85 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 150398986 Common - CRISPR-associated protein Cas5, Hmari subtype Mevan_0232 12 None None None 150399156 Nonpathogen - hypothetical protein Mevan_0403 1 None None None 150399391 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0640 41 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 150398929 Common - aminotransferase class V Mevan_0173 241 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 150399073 Nonpathogen - hypothetical protein Mevan_0319 2 None None None 150399204 Common - protein of unknown function UPF0047 Mevan_0452 137 COG0432 COG0432, Uncharacterized conserved protein Function unknown 150398811 Common - glycine betaine/L-proline ABC transporter, ATPase subunit Mevan_0052 249 COG4175 ProV, ABC-type proline/glycine betaine transport system, ATPase component Amino acid transport and metabolism 150400301 Common - protein of unknown function DUF214 Mevan_1564 188 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 150400324 Common - magnesium and cobalt transport protein CorA Mevan_1587 184 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 150399617 Common - protein of unknown function DUF512 Mevan_0867 15 COG1625 COG1625, Fe-S oxidoreductase, related to NifB/MoaA family Energy production and conversion 150399307 Nonpathogen - hypothetical protein Mevan_0555 2 None None None 150400185 Common - peptidylprolyl isomerase FKBP-type Mevan_1446 50 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 150399068 Common - RNA methyltransferase related protein Mevan_0314 13 COG1867 TRM1, N2,N2-dimethylguanosine tRNA methyltransferase Translation, ribosomal structure and biogenesis 150399729 Common - hypothetical protein Mevan_0981 142 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 150399860 Common - hypothetical protein Mevan_1115 16 None None None 150399016 Common - phage integrase family protein Mevan_0262 211 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 150400180 Nonpathogen - hypothetical protein Mevan_1441 6 COG1365 COG1365, Predicted ATPase (PP-loop superfamily) General function prediction only 150399129 Nonpathogen - regulatory protein Crp Mevan_0375 22 COG1497 COG1497, Predicted transcriptional regulator Transcription 150400239 Nonpathogen rpl34e 50S ribosomal protein L34e Mevan_1500 16 COG2174 RPL34A, Ribosomal protein L34E Translation, ribosomal structure and biogenesis 150400054 Common - hydrogenase nickel insertion protein HypA Mevan_1312 65 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 150399452 Nonpathogen - hypothetical protein Mevan_0701 2 None None None 150399378 Nonpathogen - hypothetical protein Mevan_0627 4 None None None 150400038 Common - translation initiation factor IF-2 Mevan_1296 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 150399134 Common - Protein of unknown function DUF1722 Mevan_0380 57 COG3272 COG3272, Uncharacterized conserved protein Function unknown 150399314 Common - Amidohydrolase 3 Mevan_0562 24 COG1229 FwdA, Formylmethanofuran dehydrogenase subunit A Energy production and conversion 150398958 Common - UDP-glucose/GDP-mannose dehydrogenase Mevan_0203 206 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 150399393 Common - SNARE associated Golgi protein Mevan_0642 78 COG1238 COG1238, Predicted membrane protein Function unknown 150398874 Common - hypothetical protein Mevan_0116 27 COG4938 COG4938, Uncharacterized conserved protein Function unknown 150398962 Common - carbonic anhydrase Mevan_0207 49 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 150399607 Common rpl3p 50S ribosomal protein L3P Mevan_0857 171 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 150400130 Common - methionine synthase Mevan_1388 76 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 150399644 Nonpathogen - pyruvoyl-dependent arginine decarboxylase Mevan_0894 33 COG1945 COG1945, Uncharacterized conserved protein Function unknown 150400060 Nonpathogen - zinc finger SWIM domain protein Mevan_1318 5 COG4715 COG4715, Uncharacterized conserved protein Function unknown 150399047 Common - DNA ligase I, ATP-dependent Dnl1 Mevan_0293 105 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 150399332 Nonpathogen - hypothetical protein Mevan_0580 1 None None None 150399306 Common - Sep-tRNA:Cys-tRNA synthetase Mevan_0554 84 COG1103 COG1103, Archaea-specific pyridoxal phosphate-dependent enzymes General function prediction only 150399885 Common - threonine synthase Mevan_1140 222 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 150399330 Common - glutamyl-tRNA(Gln) amidotransferase subunit E Mevan_0578 212 COG2511 GatE, Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain) Translation, ribosomal structure and biogenesis 150399001 Common - protein of unknown function DUF81 Mevan_0247 176 COG0730 COG0730, Predicted permeases General function prediction only 150399148 Common - aminotransferase class I and II Mevan_0395 241 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 150399337 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0585 7 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 150400176 Common - intracellular protease, PfpI family Mevan_1436 162 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 150399221 Nonpathogen rpl37e 50S ribosomal protein L37e Mevan_0469 29 COG2126 RPL37A, Ribosomal protein L37E Translation, ribosomal structure and biogenesis 150398845 Common - hypothetical protein Mevan_0086 8 None None None 150399008 Nonpathogen - hypothetical protein Mevan_0254 7 COG4016 COG4016, Uncharacterized protein conserved in archaea Function unknown 150400313 Nonpathogen - Uncharacterised conserved protein UCP006577 Mevan_1576 13 COG4033 COG4033, Uncharacterized protein conserved in archaea Function unknown 150399150 Nonpathogen - hypothetical protein Mevan_0397 7 COG1563 COG1563, Predicted subunit of the Multisubunit Na+/H+ antiporter Inorganic ion transport and metabolism 150398767 Nonpathogen - protein of unknown function DUF75 Mevan_0007 31 COG1938 COG1938, Archaeal enzymes of ATP-grasp superfamily General function prediction only 150399025 Common - membrane protein Mevan_0271 65 COG1073 COG1073, Hydrolases of the alpha/beta superfamily General function prediction only 150399114 Common - protein of unknown function DUF163 Mevan_0360 166 COG1576 COG1576, Uncharacterized conserved protein Function unknown 150398919 Nonpathogen - hypothetical protein Mevan_0163 1 None None None 150399159 Common - Methyltransferase type 11 Mevan_0406 28 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 150399630 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit H Mevan_0880 17 COG1962 MtrH, Tetrahydromethanopterin S-methyltransferase, subunit H Coenzyme metabolism 150400337 Common uvrC excinuclease ABC subunit C Mevan_1600 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 150400045 Nonpathogen - hypothetical protein Mevan_1303 1 None None None 150399824 Common - nitrogen regulatory protein P-II Mevan_1079 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 150399414 Common - putative thiazole biosynthetic enzyme Mevan_0663 35 COG1635 THI4, Flavoprotein involved in thiazole biosynthesis Coenzyme metabolism 150399838 Common - Glutamate synthase (NADPH) Mevan_1093 212 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 150399704 Common - SNO glutamine amidotransferase Mevan_0956 85 COG0311 PDX2, Predicted glutamine amidotransferase involved in pyridoxine biosynthesis Coenzyme metabolism 150399190 Common - Transketolase central region Mevan_0438 228 COG3958 COG3958, Transketolase, C-terminal subunit Carbohydrate transport and metabolism 150399890 Nonpathogen - DNA topoisomerase type IA zn finger domain protein Mevan_1146 2 COG1754 COG1754, Uncharacterized C-terminal domain of topoisomerase IA General function prediction only 150400107 Nonpathogen - PHP domain protein Mevan_1365 24 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 150399878 Common - cyclase family protein Mevan_1133 46 COG1878 COG1878, Predicted metal-dependent hydrolase General function prediction only 150400081 Nonpathogen - Protein of unknown function DUF63 Mevan_1339 16 COG1967 COG1967, Predicted membrane protein Function unknown 150399977 Nonpathogen - hypothetical protein Mevan_1235 2 None None None 150398768 Nonpathogen - Protein of unknown function DUF473 Mevan_0008 9 COG1935 COG1935, Uncharacterized conserved protein Function unknown 150399381 Common rps13p 30S ribosomal protein S13P Mevan_0630 178 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 150399961 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit alpha Mevan_1218 132 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 150399505 Common - small GTP-binding protein Mevan_0754 247 COG1163 DRG, Predicted GTPase General function prediction only 150400395 Common - Cobaltochelatase Mevan_1658 89 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 150399777 Nonpathogen - regulatory protein ArsR Mevan_1029 2 None None None 150399179 Common - acetylornithine and succinylornithine aminotransferase Mevan_0426 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 150399817 Common - FO synthase subunit 2 Mevan_1072 85 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 150399981 Common - Glutamate-1-semialdehyde 2,1-aminomutase Mevan_1239 53 COG0371 GldA, Glycerol dehydrogenase and related enzymes Energy production and conversion 150398867 Common - CRISPR-associated protein, Cmr5 family Mevan_0109 3 COG3337 COG3337, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 150398860 Common - hypothetical protein Mevan_0102 8 None None None 150400026 Common - ABC transporter related Mevan_1284 247 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 150400285 Common - malate dehydrogenase Mevan_1548 163 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 150398898 Common - PAS/PAC sensor signal transduction histidine kinase Mevan_0142 223 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 150399321 Common pheT phenylalanyl-tRNA synthetase subunit beta Mevan_0569 210 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 150399500 Common - SCP-like extracellular Mevan_0749 68 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 150400263 Common rps2P 30S ribosomal protein S2 Mevan_1524 105 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 150400128 Common - peptidase M48 Ste24p Mevan_1386 198 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 150400234 Common - ADP-ribosylation/Crystallin J1 Mevan_1495 82 COG1397 DraG, ADP-ribosylglycohydrolase Posttranslational modification, protein turnover, chaperones 150399628 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit A Mevan_0878 17 COG4063 MtrA, Tetrahydromethanopterin S-methyltransferase, subunit A Coenzyme metabolism 150399328 Nonpathogen - protein of unknown function UPF0153 Mevan_0576 2 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 150399355 Common - glycosyl transferase group 1 Mevan_0604 143 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 150398799 Nonpathogen - hypothetical protein Mevan_0039 1 None None None 150399731 Nonpathogen - hypothetical protein Mevan_0983 1 None None None 150399874 Nonpathogen - membrane-bound metal-dependent hydrolase Mevan_1129 5 None None None 150399871 Nonpathogen - hypothetical protein Mevan_1126 1 None None None 150398880 Common - SMF family protein Mevan_0123 208 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 150399261 Nonpathogen - hypothetical protein Mevan_0509 2 None None None 150398875 Nonpathogen - hypothetical protein Mevan_0118 1 None None None 150399899 Nonpathogen rpl40e 50S ribosomal protein L40e Mevan_1156 26 COG1552 RPL40A, Ribosomal protein L40E Translation, ribosomal structure and biogenesis 150398933 Common - serine O-acetyltransferase Mevan_0177 206 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 150399082 Common - tryptophan synthase subunit beta Mevan_0328 226 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 150399621 Nonpathogen - Methyl-coenzyme M reductase, gamma subunit Mevan_0871 14 COG4057 McrG, Methyl coenzyme M reductase, gamma subunit Coenzyme metabolism 150399066 Nonpathogen - Protein of unknown function DUF166 Mevan_0312 11 COG1810 COG1810, Uncharacterized protein conserved in archaea Function unknown 150400225 Common - Acetolactate decarboxylase Mevan_1486 40 COG3527 AlsD, Alpha-acetolactate decarboxylase Secondary metabolites biosynthesis, transport, and catabolism 150398853 Nonpathogen - hypothetical protein Mevan_0094 1 None None None 150399708 Common - hypothetical protein Mevan_0960 7 COG2456 COG2456, Uncharacterized conserved protein Function unknown 150399093 Common - exodeoxyribonuclease III Xth Mevan_0339 198 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 150399761 Nonpathogen - proliferating cell nuclear antigen PcnA Mevan_1013 34 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 150400373 Nonpathogen - hypothetical protein Mevan_1636 1 None None None 150400133 Common - Glycosyltransferase 28 domain Mevan_1391 27 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 150398787 Common - GMP synthase subunit B Mevan_0027 241 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 150399942 Nonpathogen - protein of unknown function DUF192 Mevan_1199 8 COG1430 COG1430, Uncharacterized conserved protein Function unknown 150398941 Nonpathogen - TatD-related deoxyribonuclease Mevan_0185 26 COG1831 COG1831, Predicted metal-dependent hydrolase (urease superfamily) General function prediction only 150399851 Nonpathogen - THUMP domain protein Mevan_1106 33 COG1258 COG1258, Predicted pseudouridylate synthase Translation, ribosomal structure and biogenesis 150399342 Common - GCN5-related N-acetyltransferase Mevan_0591 82 COG0456 RimI, Acetyltransferases General function prediction only 150399903 Common - protein of unknown function UPF0044 Mevan_1160 63 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 150400154 Nonpathogen - vanadium nitrogenase-associated related protein N Mevan_1413 16 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 150400262 Nonpathogen - hypothetical protein Mevan_1523 18 COG1326 COG1326, Uncharacterized archaeal Zn-finger protein General function prediction only 150400165 Common - dihydroorotate dehydrogenase 1B Mevan_1424 221 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 150400123 Common - Uroporphyrinogen III synthase HEM4 Mevan_1381 54 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 150398946 Nonpathogen - hypothetical protein Mevan_0190 3 None None None 150399430 Common - elongation factor EF-2 Mevan_0679 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 150399118 Common - H+transporting two-sector ATPase E subunit Mevan_0364 11 COG1390 NtpE, Archaeal/vacuolar-type H+-ATPase subunit E Energy production and conversion 150399831 Common - argininosuccinate synthase Mevan_1086 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 150399916 Common - transcriptional regulator, PadR-like family Mevan_1173 28 COG1695 COG1695, Predicted transcriptional regulators Transcription 150399266 Common - phosphate uptake regulator, PhoU Mevan_0514 47 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 150399563 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0812 170 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 150399937 Common - GTP-binding protein HSR1-related Mevan_1194 157 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 150399507 Common - GMP synthase subunit A Mevan_0756 241 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 150398813 Common - Substrate-binding region of ABC-type glycine betaine transport system Mevan_0054 75 COG2113 ProX, ABC-type proline/glycine betaine transport systems, periplasmic components Amino acid transport and metabolism 150400218 Nonpathogen - Protein of unknown function DUF128 Mevan_1479 16 COG1693 COG1693, Uncharacterized protein conserved in archaea Function unknown 150398994 Nonpathogen - tRNA CCA-pyrophosphorylase Mevan_0240 34 COG1746 CCA1, tRNA nucleotidyltransferase (CCA-adding enzyme) Translation, ribosomal structure and biogenesis 150399541 Common - cobalt transport protein CbiM Mevan_0790 74 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 150399745 Common - NADH ubiquinone oxidoreductase 20 kDa subunit Mevan_0997 51 COG1941 FrhG, Coenzyme F420-reducing hydrogenase, gamma subunit Energy production and conversion 150399785 Common - type II secretion system protein E Mevan_1037 223 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 150399828 Nonpathogen - glutamate synthase alpha subunit domain protein Mevan_1083 10 COG2218 FwdC, Formylmethanofuran dehydrogenase subunit C Energy production and conversion 150398978 Common - hypothetical protein Mevan_0223 5 None None None 150398801 Common - seryl-tRNA synthetase Mevan_0041 22 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 150399054 Common - hypothetical protein Mevan_0300 22 COG0348 NapH, Polyferredoxin Energy production and conversion 150399361 Nonpathogen - hypothetical protein Mevan_0610 4 None None None 150399426 Nonpathogen - 50S ribosomal protein L30e Mevan_0675 28 COG1911 RPL30, Ribosomal protein L30E Translation, ribosomal structure and biogenesis 150399299 Common - formate dehydrogenase family accessory protein FdhD Mevan_0547 129 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 150400388 Nonpathogen - Protein of unknown function DUF1610 Mevan_1651 1 None None None 150399693 Common - S-adenosylmethionine synthetase Mevan_0945 43 COG1812 MetK, Archaeal S-adenosylmethionine synthetase Amino acid transport and metabolism 150399288 Common - precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit Mevan_0536 83 COG2242 CobL, Precorrin-6B methylase 2 Coenzyme metabolism 150399199 Common - thiamine-monophosphate kinase Mevan_0447 189 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 150400211 Nonpathogen - hypothetical protein Mevan_1472 1 None None None 150400117 Common - geranylgeranyl reductase Mevan_1375 139 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 150400146 Common - phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Mevan_1405 216 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 150399558 Nonpathogen - hypothetical protein Mevan_0807 7 COG4017 COG4017, Uncharacterized protein conserved in archaea Function unknown 150399773 Common - cobyrinic acid a,c-diamide synthase Mevan_1025 33 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 150399654 Common - tryptophanyl-tRNA synthetase Mevan_0904 234 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150400275 Nonpathogen - hypothetical protein Mevan_1537 1 None None None 150399182 Common - aspartate carbamoyltransferase regulatory subunit Mevan_0429 65 COG1781 PyrI, Aspartate carbamoyltransferase, regulatory subunit Nucleotide transport and metabolism 150399206 Nonpathogen - tRNA-splicing endonuclease subunit alpha Mevan_0454 34 COG1676 SEN2, tRNA splicing endonuclease Translation, ribosomal structure and biogenesis 150400135 Nonpathogen - GTP cyclohydrolase III Mevan_1393 15 COG2429 COG2429, Uncharacterized conserved protein Function unknown 150399604 Nonpathogen - hypothetical protein Mevan_0853 6 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 150400207 Nonpathogen - Pre-mRNA processing ribonucleoprotein, binding region Mevan_1468 34 COG1498 SIK1, Protein implicated in ribosomal biogenesis, Nop56p homolog Translation, ribosomal structure and biogenesis 150399591 Common - aspartate aminotransferase Mevan_0840 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 150400258 Common - 2-dehydropantoate 2-reductase Mevan_1519 121 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 150399598 Nonpathogen - hypothetical protein Mevan_0847 30 COG1936 COG1936, Predicted nucleotide kinase (related to CMP and AMP kinases) Nucleotide transport and metabolism 150400043 Nonpathogen nac nascent polypeptide-associated complex protein Mevan_1301 18 COG1308 EGD2, Transcription factor homologous to NACalpha-BTF3 Transcription 150399675 Common aspC aspartyl-tRNA synthetase Mevan_0926 249 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 150399253 Common - hydrogenase maturation protease HycI Mevan_0501 45 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 150399952 Common - CoA-binding domain protein Mevan_1209 120 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 150400251 Common upp uracil phosphoribosyltransferase Mevan_1512 165 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 150399793 Nonpathogen - hypothetical protein Mevan_1047 3 None None None 150399213 Common thiE thiamine-phosphate pyrophosphorylase Mevan_0461 199 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 150399807 Common - Radical SAM domain protein Mevan_1062 194 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 150400126 Common alaS alanyl-tRNA synthetase Mevan_1384 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150399686 Common - hydrogenase subunit F Mevan_0937 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 150400184 Common moaA molybdenum cofactor biosynthesis protein A Mevan_1445 202 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 150398823 Common - nitrogen regulatory protein P-II Mevan_0064 189 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 150400063 Nonpathogen - hypothetical protein Mevan_1321 14 COG1590 COG1590, Uncharacterized conserved protein Function unknown 150400161 Nonpathogen - hypothetical protein Mevan_1420 5 None None None 150399371 Nonpathogen - IMP cyclohydrolase Mevan_0620 13 COG3363 COG3363, Archaeal IMP cyclohydrolase Nucleotide transport and metabolism 150398903 Common - MIP family channel protein Mevan_0147 135 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 150400002 Nonpathogen - ribosomal biogenesis protein Mevan_1260 13 COG2136 IMP4, Predicted exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component, contains IMP4 domain Translation, ribosomal structure and biogenesis / RNA processing and modification 150399397 Common - mevalonate kinase Mevan_0646 52 COG1577 ERG12, Mevalonate kinase Lipid metabolism 150399270 Common cbiD cobalt-precorrin-6A synthase Mevan_0518 90 COG1903 CbiD, Cobalamin biosynthesis protein CbiD Coenzyme metabolism 150399516 Nonpathogen - hypothetical protein Mevan_0765 8 COG4036 COG4036, Predicted membrane protein Function unknown 150399736 Common - H/ACA RNA-protein complex component Cbf5p Mevan_0988 242 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 150400291 Nonpathogen rps28e 30S ribosomal protein S28e Mevan_1554 33 COG2053 RPS28A, Ribosomal protein S28E/S33 Translation, ribosomal structure and biogenesis 150399640 Common - nicotinamide-nucleotide adenylyltransferase Mevan_0890 38 COG1056 NadR, Nicotinamide mononucleotide adenylyltransferase Coenzyme metabolism 150399486 Common - Oligosaccharyl transferase STT3 subunit Mevan_0735 24 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 150399767 Common - Methyltransferase type 12 Mevan_1019 17 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 150400315 Common - transcriptional regulator, PadR-like family Mevan_1578 8 COG1695 COG1695, Predicted transcriptional regulators Transcription 150400245 Common - fructose-bisphosphate aldolase Mevan_1506 91 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 150399247 Common - periplasmic binding protein Mevan_0495 76 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 150398835 Common - coenzyme F420-reducing hydrogenase subunit beta Mevan_0076 39 COG1035 FrhB, Coenzyme F420-reducing hydrogenase, beta subunit Energy production and conversion 150400191 Nonpathogen - protein of unknown function DUF115 Mevan_1452 31 COG1634 COG1634, Uncharacterized Rossmann fold enzyme General function prediction only 150400237 Nonpathogen - 50S ribosomal protein L14e Mevan_1498 18 COG2163 RPL14A, Ribosomal protein L14E/L6E/L27E Translation, ribosomal structure and biogenesis 150398779 Common - hypothetical protein Mevan_0019 31 COG1786 COG1786, Uncharacterized conserved protein Function unknown 150400308 Common - Xanthine/uracil/vitamin C permease Mevan_1571 135 COG2252 COG2252, Permeases General function prediction only 150399161 Common - branched-chain amino acid aminotransferase Mevan_0408 215 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 150398912 Nonpathogen - hypothetical protein Mevan_0156 1 None None None 150398939 Common - methyltransferase small Mevan_0183 86 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 150400196 Common - UspA domain protein Mevan_1457 61 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 150400050 Nonpathogen - translation initiation factor IF-2 subunit beta Mevan_1308 34 COG1601 GCD7, Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain Translation, ribosomal structure and biogenesis 150398789 Common - Exonuclease RNase T and DNA polymerase III Mevan_0029 67 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 150400303 Nonpathogen - ATP/GTP-binding site motif A (P-loop) Mevan_1566 1 None None None 150399844 Common - 3-hydroxy-3-methylglutaryl Coenzyme A reductase Mevan_1099 56 COG1257 HMG1, Hydroxymethylglutaryl-CoA reductase Lipid metabolism 150399230 Nonpathogen - MTH865-like family protein Mevan_0478 3 COG4746 COG4746, Uncharacterized protein conserved in archaea Function unknown 150399294 Nonpathogen - FUN14 family protein Mevan_0542 4 COG2383 COG2383, Uncharacterized conserved protein Function unknown 150399754 Nonpathogen - hypothetical protein Mevan_1006 14 COG4008 COG4008, Predicted metal-binding transcription factor Transcription 150399535 Common ileS isoleucyl-tRNA synthetase Mevan_0784 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150399551 Common - amidohydrolase Mevan_0800 176 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 150399352 Common - Alpha-amylase Mevan_0601 24 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 150399108 Nonpathogen - adenylate kinase Mevan_0354 23 COG2019 AdkA, Archaeal adenylate kinase Nucleotide transport and metabolism 150399946 Common - transcriptional regulator, LysR family Mevan_1203 7 COG0583 LysR, Transcriptional regulator Transcription 150399532 Common - protein of unknown function DUF795 Mevan_0781 13 COG1323 COG1323, Predicted nucleotidyltransferase General function prediction only 150399866 Common argC N-acetyl-gamma-glutamyl-phosphate reductase Mevan_1121 218 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 150400150 Nonpathogen - conserved archael hypothetical protein Mevan_1409 2 None None None 150398976 Common - CheD, stimulates methylation of MCP proteins Mevan_0221 87 COG1871 CheD, Chemotaxis protein; stimulates methylation of MCP proteins Cell motility and secretion / Signal transduction mechanisms 150399075 Nonpathogen - hypothetical protein Mevan_0321 5 None None None 150400092 Common - pyruvate carboxylase subunit B Mevan_1350 204 COG5016 COG5016, Pyruvate/oxaloacetate carboxyltransferase Energy production and conversion 150399493 Nonpathogen - 2-phosphoglycerate kinase Mevan_0742 14 COG2074 COG2074, 2-phosphoglycerate kinase Carbohydrate transport and metabolism 150399122 Common - V-type ATP synthase subunit B Mevan_0368 247 COG1156 NtpB, Archaeal/vacuolar-type H+-ATPase subunit B Energy production and conversion 150399076 Nonpathogen - hypothetical protein Mevan_0322 1 None None None 150398924 Common - hypothetical protein Mevan_0168 3 None None None 150399390 Common - enolase Mevan_0639 106 COG0148 Eno, Enolase Carbohydrate transport and metabolism 150399402 Common - metallophosphoesterase Mevan_0651 67 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 150399796 Nonpathogen tfb transcription initiation factor IIB Mevan_1050 34 COG1405 SUA7, Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB Transcription 150400149 Nonpathogen - hypothetical protein Mevan_1408 14 COG4052 COG4052, Uncharacterized protein related to methyl coenzyme M reductase subunit C General function prediction only 150399973 Nonpathogen - hypothetical protein Mevan_1230 1 None None None 150399841 Common - methyl-accepting chemotaxis sensory transducer Mevan_1096 169 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 150399573 Common gatA aspartyl/glutamyl-tRNA amidotransferase subunit A Mevan_0822 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 150400411 Nonpathogen - hypothetical protein Mevan_1674 1 None None None 150399300 Common - UBA/THIF-type NAD/FAD binding protein Mevan_0548 222 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 150400232 Common - ABC transporter related Mevan_1493 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 150399747 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0999 45 COG1148 HdrA, Heterodisulfide reductase, subunit A and related polyferredoxins Energy production and conversion 150399740 Common - hisA/hisF family protein Mevan_0992 155 COG1411 COG1411, Uncharacterized protein related to proFAR isomerase (HisA) General function prediction only 150400036 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_1294 15 COG0716 FldA, Flavodoxins Energy production and conversion 150399037 Common - extracellular solute-binding protein family 3 Mevan_0283 179 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 150399335 Common - pyruvate ferredoxin/flavodoxin oxidoreductase Mevan_0583 110 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 150399136 Common - protein of unknown function UPF0029 Mevan_0383 130 COG1739 COG1739, Uncharacterized conserved protein Function unknown 150400178 Nonpathogen - hypothetical protein Mevan_1439 11 COG4090 COG4090, Uncharacterized protein conserved in archaea Function unknown 150400013 Nonpathogen rpl12p 50S ribosomal protein L12P Mevan_1271 32 COG2058 RPP1A, Ribosomal protein L12E/L44/L45/RPP1/RPP2 Translation, ribosomal structure and biogenesis 150398765 Nonpathogen - PRC-barrel domain protein Mevan_0005 3 COG1873 COG1873, Uncharacterized conserved protein Function unknown 150399752 Common - homoserine dehydrogenase Mevan_1004 219 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 150399632 Nonpathogen - hypothetical protein Mevan_0882 2 COG4009 COG4009, Uncharacterized protein conserved in archaea Function unknown 150399042 Nonpathogen - hypothetical protein Mevan_0288 1 None None None 150399315 Common - Formylmethanofuran dehydrogenase Mevan_0563 22 COG2218 FwdC, Formylmethanofuran dehydrogenase subunit C Energy production and conversion 150399116 Common - V-type ATP synthase subunit I Mevan_0362 51 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 150400065 Nonpathogen - hypothetical protein Mevan_1323 14 COG4050 COG4050, Uncharacterized protein conserved in archaea Function unknown 150399586 Common - conserved hypothetical protein 374 Mevan_0835 33 COG0392 COG0392, Predicted integral membrane protein Function unknown 150399152 Common - Nucleotidyl transferase Mevan_0399 242 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 150399713 Nonpathogen - hypothetical protein Mevan_0965 1 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 150399661 Common - TrkA-N domain protein Mevan_0911 183 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 150398893 Common - methyl-accepting chemotaxis sensory transducer Mevan_0137 163 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 150399514 Nonpathogen - hypothetical protein Mevan_0763 8 COG4038 COG4038, Predicted membrane protein Function unknown 150399228 Nonpathogen - Carboxymuconolactone decarboxylase Mevan_0476 5 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 150400121 Common - phosphoribosylamine--glycine ligase Mevan_1379 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 150399027 Common - Cupin 2 conserved barrel domain protein Mevan_0273 68 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 150399060 Common - acetyl-CoA decarbonylase/synthase complex subunit gamma Mevan_0306 23 COG1456 CdhE, CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) Energy production and conversion 150399192 Common - Transketolase Mevan_0440 222 COG3959 COG3959, Transketolase, N-terminal subunit Carbohydrate transport and metabolism 150399858 Common - pyridoxine biosynthesis protein Mevan_1113 87 COG0214 SNZ1, Pyridoxine biosynthesis enzyme Coenzyme metabolism 150399615 Common - signal recognition particle protein Srp54 Mevan_0865 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 150399806 Nonpathogen - hypothetical protein Mevan_1061 7 COG4072 COG4072, Uncharacterized protein conserved in archaea Function unknown 150399653 Common - cobalamin (vitamin B12) biosynthesis CbiG protein Mevan_0903 59 COG2073 CbiG, Cobalamin biosynthesis protein CbiG Coenzyme metabolism 150399734 Nonpathogen - hypothetical protein Mevan_0986 2 None None None 150399918 Common - alpha-L-glutamate ligase, RimK family Mevan_1175 107 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 150399727 Nonpathogen - Protein of unknown function UPF0179 Mevan_0979 23 COG1860 COG1860, Uncharacterized protein conserved in archaea Function unknown 150399309 Nonpathogen - UBA/THIF-type NAD/FAD binding protein Mevan_0557 7 COG4015 COG4015, Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family General function prediction only 150400393 Nonpathogen - hypothetical protein Mevan_1656 2 None None None 150400083 Common cbiC precorrin-8X methylmutase Mevan_1341 119 COG2082 CobH, Precorrin isomerase Coenzyme metabolism 150399208 Common - beta-lactamase domain protein Mevan_0456 79 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 150398896 Common - integral membrane sensor signal transduction histidine kinase Mevan_0140 222 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 150398969 Nonpathogen - RNAse P, Rpr2/Rpp21 subunit Mevan_0214 21 COG2023 RPR2, RNase P subunit RPR2 Translation, ribosomal structure and biogenesis 150399030 Common - aldo/keto reductase Mevan_0276 170 COG1453 COG1453, Predicted oxidoreductases of the aldo/keto reductase family General function prediction only 150400362 Nonpathogen - hypothetical protein Mevan_1625 2 None None None 150399759 Nonpathogen rpl44e 50S ribosomal protein L44e Mevan_1011 32 COG1631 RPL42A, Ribosomal protein L44E Translation, ribosomal structure and biogenesis 150399006 Common - F420-0--gamma-glutamyl ligase Mevan_0252 44 COG1478 COG1478, Uncharacterized conserved protein Function unknown 150398964 Common - hypothetical protein Mevan_0209 22 COG2406 COG2406, Protein distantly related to bacterial ferritins General function prediction only 150399310 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0558 20 COG1148 HdrA, Heterodisulfide reductase, subunit A and related polyferredoxins Energy production and conversion 150400243 Nonpathogen - hypothetical protein Mevan_1504 1 None None None 150400269 Common - adenine phosphoribosyltransferase Mevan_1531 190 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 150400405 Common - transcriptional regulator, TetR family Mevan_1668 46 COG1309 AcrR, Transcriptional regulator Transcription 150399357 Nonpathogen - ADP-specific phosphofructokinase Mevan_0606 8 COG4809 COG4809, Archaeal ADP-dependent phosphofructokinase/glucokinase Carbohydrate transport and metabolism 150399170 Common - Auxin Efflux Carrier Mevan_0417 138 COG0679 COG0679, Predicted permeases General function prediction only 150399622 Nonpathogen - Coenzyme-B sulfoethylthiotransferase Mevan_0872 14 COG4058 McrA, Methyl coenzyme M reductase, alpha subunit Coenzyme metabolism 150400270 Common - peptidase U32 Mevan_1532 140 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 150399501 Common - cofactor-independent phosphoglycerate mutase Mevan_0750 60 COG3635 COG3635, Predicted phosphoglycerate mutase, AP superfamily Carbohydrate transport and metabolism 150400328 Common - amino acid-binding ACT domain protein Mevan_1591 38 COG4747 COG4747, ACT domain-containing protein General function prediction only 150399084 Common - anthranilate synthase component II Mevan_0330 241 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 150399524 Common - NADH dehydrogenase (quinone) Mevan_0773 195 COG3261 HycE, Ni,Fe-hydrogenase III large subunit Energy production and conversion 150400323 Common - hypothetical protein Mevan_1586 26 COG1891 COG1891, Uncharacterized protein conserved in archaea Function unknown 150400283 Common - protein of unknown function DUF101 Mevan_1546 41 COG1371 COG1371, Uncharacterized conserved protein Function unknown 150399908 Common - Phenylacetate--CoA ligase Mevan_1165 113 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 150398877 Nonpathogen - hypothetical protein Mevan_0120 2 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 150398855 Common - hypothetical protein Mevan_0096 59 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 150399368 Common - methyltransferase related protein Mevan_0617 139 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 150399344 Nonpathogen - hypothetical protein Mevan_0593 1 None None None 150399456 Common - 3-dehydroquinate dehydratase, type I Mevan_0705 54 COG0710 AroD, 3-dehydroquinate dehydratase Amino acid transport and metabolism 150398943 Common - hypothetical protein Mevan_0187 6 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 150399988 Nonpathogen - hypothetical protein Mevan_1246 2 COG1991 COG1991, Uncharacterized conserved protein Function unknown 150399788 Nonpathogen - hypothetical protein Mevan_1041 3 None None None 150399876 Common - biotin synthase Mevan_1131 195 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 150398887 Common - periplasmic binding protein Mevan_0131 24 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 150400152 Nonpathogen - hypothetical protein Mevan_1411 2 None None None 150400335 Nonpathogen - hypothetical protein Mevan_1598 1 None None None 150399095 Common - carbamoyl-phosphate synthase, large subunit Mevan_0341 236 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 150399901 Common aksA trans-homoaconitate synthase Mevan_1158 218 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 150400028 Common - hydrogenase expression/formation protein HypE Mevan_1286 181 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 150399968 Common - MATE efflux family protein Mevan_1225 116 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 150399892 Nonpathogen - hypothetical protein Mevan_1148 9 COG4069 COG4069, Uncharacterized protein conserved in archaea Function unknown 150399014 Nonpathogen - hypothetical protein Mevan_0260 1 None None None 150399466 Common rps3p 30S ribosomal protein S3P Mevan_0715 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 150399548 Common - peptidase U62 modulator of DNA gyrase Mevan_0797 169 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 150398984 Nonpathogen - CRISPR-associated protein, TM1802 family Mevan_0230 7 None None None 150399975 Common - regulatory protein ArsR Mevan_1232 140 COG0640 ArsR, Predicted transcriptional regulators Transcription 150399131 Common - CoB--CoM heterodisulfide reductase Mevan_0377 43 COG1150 HdrC, Heterodisulfide reductase, subunit C Energy production and conversion 150399449 Common - redox-active disulfide protein 2 Mevan_0698 54 None None None 150400384 Common - phage integrase family protein Mevan_1647 212 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 150399475 Nonpathogen rps14P 30S ribosomal protein S14P Mevan_0724 33 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 150400350 Common - hypothetical protein Mevan_1613 12 COG3904 COG3904, Predicted periplasmic protein Function unknown 150400429 Nonpathogen - hypothetical protein Mevan_1692 1 None None None 150399177 Common - phosphate uptake regulator, PhoU Mevan_0424 193 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 150399819 Nonpathogen - hypothetical protein Mevan_1074 4 None None None 150400277 Nonpathogen - hypothetical protein Mevan_1539 1 None None None 150400109 Common - DNA polymerase Pol2 Mevan_1367 66 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 150398862 Common - hypothetical protein Mevan_0104 2 None None None 150399664 Common - protein of unknown function DUF39 Mevan_0914 35 COG1900 COG1900, Uncharacterized conserved protein Function unknown 150400100 Common - putative CoA-substrate-specific enzyme activase Mevan_1358 65 COG1924 COG1924, Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) Lipid metabolism 150399880 Common - fumarate hydratase Mevan_1135 148 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 150399775 Common - MCM family protein Mevan_1027 37 COG1241 MCM2, Predicted ATPase involved in replication control, Cdc46/Mcm family DNA replication, recombination, and repair 150398869 Common - hypothetical protein Mevan_0111 4 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 150399887 Common - putative deoxyhypusine synthase Mevan_1142 55 COG1899 DYS1, Deoxyhypusine synthase Posttranslational modification, protein turnover, chaperones 150399810 Common ribH riboflavin synthase subunit beta Mevan_1065 189 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 150399450 Common - major facilitator superfamily MFS_1 Mevan_0699 25 None None None 150400016 Nonpathogen - RNA polymerase dimerisation Mevan_1274 2 COG1761 RPB11, DNA-directed RNA polymerase, subunit L Transcription 150399135 Common cysS cysteinyl-tRNA synthetase Mevan_0382 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150399440 Common thyA thymidylate synthase Mevan_0689 93 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 150400434 Nonpathogen - protein of unknown function DUF98 Mevan_1697 12 COG3161 UbiC, 4-hydroxybenzoate synthetase (chorismate lyase) Coenzyme metabolism 150399842 Nonpathogen - putative translation factor pelota Mevan_1097 33 COG1537 PelA, Predicted RNA-binding proteins General function prediction only 150398790 Common - DEAD/DEAH box helicase domain protein Mevan_0030 143 COG1204 COG1204, Superfamily II helicase General function prediction only 150399052 Nonpathogen - hypothetical protein Mevan_0298 1 None None None 150399059 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0305 167 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 150400317 Common - alpha-L-glutamate ligase, RimK family Mevan_1580 106 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 150399910 Common - protein of unknown function DUF116 Mevan_1167 31 COG1852 COG1852, Uncharacterized conserved protein Function unknown 150399447 Common - conserved hypothetical protein 341 Mevan_0696 56 COG1808 COG1808, Predicted membrane protein Function unknown 150399477 Common rpl6p 50S ribosomal protein L6P Mevan_0726 186 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 150399494 Common - adenylosuccinate synthetase Mevan_0743 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 150399735 Nonpathogen - hypothetical protein Mevan_0987 2 COG1991 COG1991, Uncharacterized conserved protein Function unknown 150399868 Common - beta-lactamase domain protein Mevan_1123 176 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 150399940 Common - AAA ATPase central domain protein Mevan_1197 249 COG1223 COG1223, Predicted ATPase (AAA+ superfamily) General function prediction only 150399998 Nonpathogen - Protein of unknown function DUF372 Mevan_1256 20 COG2098 COG2098, Uncharacterized protein conserved in archaea Function unknown 150399751 Nonpathogen - amino acid-binding ACT domain protein Mevan_1003 18 COG2061 COG2061, ACT-domain-containing protein, predicted allosteric regulator of homoserine dehydrogenase Amino acid transport and metabolism 150400375 Nonpathogen - hypothetical protein Mevan_1638 1 None None None 150399186 Nonpathogen - Protein of unknown function DUF373 Mevan_0434 29 COG2237 COG2237, Predicted membrane protein Function unknown 150399128 Common - stationary-phase survival protein SurE Mevan_0374 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 150399538 Common - cobyrinic acid a,c-diamide synthase Mevan_0787 136 COG1797 CobB, Cobyrinic acid a,c-diamide synthase Coenzyme metabolism 150398836 Common - Flavodoxin-like protein Mevan_0077 37 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 150400167 Nonpathogen - DNA-directed RNA polymerase subunit E, RpoE2 Mevan_1426 20 COG2093 COG2093, DNA-directed RNA polymerase, subunit E'' Transcription 150400387 Nonpathogen - hypothetical protein Mevan_1650 1 None None None 150399109 Nonpathogen - replication factor A Mevan_0355 30 COG1599 RFA1, Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins DNA replication, recombination, and repair 150398913 Common - succinyl-CoA synthetase subunit alpha Mevan_0157 216 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 150399239 Common - Archaeoflavoprotein AfpA Mevan_0487 20 COG1036 COG1036, Archaeal flavoproteins Energy production and conversion 150400078 Nonpathogen - glyceraldehyde-3-phosphate dehydrogenase Mevan_1336 34 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 150399078 Common - protein of unknown function DUF340 membrane Mevan_0324 49 COG2431 COG2431, Predicted membrane protein Function unknown 150399339 Common sdhA succinate dehydrogenase flavoprotein subunit Mevan_0588 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 150399518 Nonpathogen - hypothetical protein Mevan_0767 1 None None None 150398963 Common - zinc/iron permease Mevan_0208 89 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 150399787 Nonpathogen - H/ACA RNA-protein complex component Gar1 Mevan_1039 2 COG3277 GAR1, RNA-binding protein involved in rRNA processing Translation, ribosomal structure and biogenesis 150400242 Common - GCN5-related N-acetyltransferase Mevan_1503 91 COG3153 COG3153, Predicted acetyltransferase General function prediction only 150398815 Common - sodium/hydrogen exchanger Mevan_0056 154 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 150400216 Nonpathogen - KH type 1 domain protein Mevan_1477 34 COG1094 COG1094, Predicted RNA-binding protein (contains KH domains) General function prediction only 150400003 Nonpathogen - RNA polymerase Rbp10 Mevan_1261 2 COG1996 RPC10, DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger) Transcription 150399652 Common - ExsB family protein Mevan_0902 10 COG1365 COG1365, Predicted ATPase (PP-loop superfamily) General function prediction only 150400259 Common - hypothetical protein Mevan_1520 22 COG4895 COG4895, Uncharacterized conserved protein Function unknown 150399919 Common - conserved hypothetical protein 245 Mevan_1176 70 COG0390 COG0390, ABC-type uncharacterized transport system, permease component General function prediction only 150400322 Common - sodium/hydrogen exchanger Mevan_1585 91 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 150400346 Nonpathogen - hypothetical protein Mevan_1609 10 COG3672 COG3672, Predicted periplasmic protein Function unknown 150399520 Nonpathogen - hypothetical protein Mevan_0769 1 None None None 150399246 Common - periplasmic binding protein Mevan_0494 84 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 150398974 Common - response regulator receiver modulated CheB methylesterase Mevan_0219 219 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 150400160 Common - protein of unknown function DUF378 Mevan_1419 24 COG2155 COG2155, Uncharacterized conserved protein Function unknown 150399087 Common trpC indole-3-glycerol-phosphate synthase Mevan_0333 219 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 150399765 Common - small GTP-binding protein Mevan_1017 226 COG2229 COG2229, Predicted GTPase General function prediction only 150398925 Common - PP-loop domain protein Mevan_0169 127 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 150400115 Nonpathogen - Transcription factor CBF/NF-Y histone Mevan_1373 23 COG2036 HHT1, Histones H3 and H4 Chromatin structure and dynamics 150399780 Common - protein of unknown function DUF201 Mevan_1032 23 COG2232 COG2232, Predicted ATP-dependent carboligase related to biotin carboxylase General function prediction only 150398995 Nonpathogen - Protein of unknown function UPF0058 Mevan_0241 13 COG1745 COG1745, Predicted metal-binding protein General function prediction only 150399252 Nonpathogen - GCN5-related N-acetyltransferase Mevan_0500 3 COG0456 RimI, Acetyltransferases General function prediction only 150399791 Nonpathogen tfb transcription initiation factor IIB Mevan_1044 34 COG1405 SUA7, Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB Transcription 150400125 Common - Phosphopyruvate hydratase Mevan_1383 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 150400205 Common - Citrate transporter Mevan_1466 125 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 150400294 Nonpathogen - hypothetical protein Mevan_1557 1 None None None 150399864 Nonpathogen - Xylose isomerase domain protein TIM barrel Mevan_1119 6 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 150400090 Nonpathogen - hypothetical protein Mevan_1348 14 COG4029 COG4029, Uncharacterized protein conserved in archaea Function unknown 150399276 Nonpathogen - hypothetical protein Mevan_0524 7 COG1630 COG1630, Uncharacterized protein conserved in archaea Function unknown 150400020 Common - multiple antibiotic resistance (MarC)-related protein Mevan_1278 157 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 150399804 Common - beta-lactamase domain protein Mevan_1059 161 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 150400055 Nonpathogen - Rubredoxin-type Fe(Cys)4 protein Mevan_1313 1 COG1773 COG1773, Rubredoxin Energy production and conversion 150399923 Common - AAA family ATPase, CDC48 subfamily Mevan_1180 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 150399690 Common - protein of unknown function DUF169 Mevan_0942 27 COG2043 COG2043, Uncharacterized protein conserved in archaea Function unknown 150398997 Common gatB aspartyl/glutamyl-tRNA amidotransferase subunit B Mevan_0243 214 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 150399954 Nonpathogen - DNA primase, large subunit Mevan_1211 3 COG2219 PRI2, Eukaryotic-type DNA primase, large subunit DNA replication, recombination, and repair 150399677 Common - molybdenum cofactor synthesis domain Mevan_0928 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 150398802 Nonpathogen - Ribonuclease P-related Mevan_0042 13 COG1369 POP5, RNase P/RNase MRP subunit POP5 Translation, ribosomal structure and biogenesis 150398824 Common nifH nitrogenase reductase Mevan_0065 70 COG1348 NifH, Nitrogenase subunit NifH (ATPase) Inorganic ion transport and metabolism 150398959 Common - oxidoreductase domain protein Mevan_0204 190 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 150398952 Nonpathogen - protein of unknown function DUF354 Mevan_0197 13 COG1817 COG1817, Uncharacterized protein conserved in archaea Function unknown 150400034 Common - PilT protein domain protein Mevan_1292 41 COG1855 COG1855, ATPase (PilT family) General function prediction only 150399011 Common - CheC, inhibitor of MCP methylation Mevan_0257 26 COG1776 CheC, Chemotaxis protein CheC, inhibitor of MCP methylation Cell motility and secretion / Signal transduction mechanisms 150398809 Common - protein of unknown function DUF214 Mevan_0049 189 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 150398849 Nonpathogen - hypothetical protein Mevan_0090 6 None None None 150399293 Nonpathogen - hypothetical protein Mevan_0541 2 None None None 150399596 Common pgk phosphoglycerate kinase Mevan_0845 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 150399995 Nonpathogen - hypothetical protein Mevan_1253 2 None None None 150398940 Nonpathogen - Peptidase A24B, FlaK-like protein Mevan_0184 5 COG4960 CpaA, Flp pilus assembly protein, protease CpaA Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 150400403 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Mevan_1666 163 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 150399540 Common - homoaconitate hydratase family protein Mevan_0789 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 150398947 Nonpathogen - hypothetical protein Mevan_0191 7 None None None 150399145 Common - signal peptide peptidase SppA, 36K type Mevan_0392 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 150399881 Common - Pyridoxal-dependent decarboxylase Mevan_1136 125 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 150399900 Common - Citrate transporter Mevan_1157 187 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 150400140 Common - ribose-phosphate pyrophosphokinase Mevan_1398 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 150399681 Common - ferredoxin Mevan_0932 33 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 150399363 Nonpathogen - hypothetical protein Mevan_0612 1 None None None 150399564 Common - pyruvate ferredoxin oxidoreductase subunit beta Mevan_0813 123 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 150399601 Nonpathogen - cytochrome c heme-binding site Mevan_0850 3 None None None 150399685 Nonpathogen - hypothetical protein Mevan_0936 2 None None None 150399437 Common - phage shock protein C, PspC Mevan_0686 23 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 150399894 Common - adenine phosphoribosyltransferase Mevan_1150 164 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 150400352 Nonpathogen - hypothetical protein Mevan_1615 1 None None None 150398826 Common - molybdopterin oxidoreductase Mevan_0067 146 COG1029 FwdB, Formylmethanofuran dehydrogenase subunit B Energy production and conversion 150399576 Common - alanine dehydrogenase Mevan_0825 167 COG0686 Ald, Alanine dehydrogenase Amino acid transport and metabolism 150399418 Nonpathogen - thiamineS protein Mevan_0667 1 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 150399966 Common - lysine 2,3-aminomutase YodO family protein Mevan_1223 127 COG1509 KamA, Lysine 2,3-aminomutase Amino acid transport and metabolism 150400309 Common - beta-lactamase domain protein Mevan_1572 150 COG1782 COG1782, Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain General function prediction only 150400240 Common - TOBE domain protein Mevan_1501 72 COG3585 MopI, Molybdopterin-binding protein Coenzyme metabolism 150399972 Common - non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family Mevan_1229 226 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 150400418 Nonpathogen - transcriptional regulator, TrmB Mevan_1681 5 COG2512 COG2512, Uncharacterized membrane-associated protein/domain Function unknown 150399385 Nonpathogen - 50S ribosomal protein L18e Mevan_0634 34 COG1727 RPL18A, Ribosomal protein L18E Translation, ribosomal structure and biogenesis 150398884 Common - ABC transporter related Mevan_0128 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 150400272 Common - hypothetical protein Mevan_1534 44 COG3830 COG3830, ACT domain-containing protein Signal transduction mechanisms 150399388 Nonpathogen - DNA-directed RNA polymerase subunit N Mevan_0637 34 COG1644 RPB10, DNA-directed RNA polymerase, subunit N (RpoN/RPB10) Transcription 150399413 Common - ribosomal-protein-alanine acetyltransferase Mevan_0662 58 COG0456 RimI, Acetyltransferases General function prediction only 150399503 Common - molybdopterin-guanine dinucleotide biosynthesis protein B Mevan_0752 55 COG1763 MobB, Molybdopterin-guanine dinucleotide biosynthesis protein Coenzyme metabolism 150399666 Common - pyruvate kinase Mevan_0916 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 150399985 Common - metal dependent phosphohydrolase Mevan_1243 47 COG3481 COG3481, Predicted HD-superfamily hydrolase General function prediction only 150399635 Common - dethiobiotin synthase Mevan_0885 160 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 150400142 Common - MiaB-like tRNA modifying enzyme Mevan_1400 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 150400360 Common - 2-hydroxyglutaryl-CoA dehydratase D-component Mevan_1623 35 COG1775 HgdB, Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB Amino acid transport and metabolism 150399373 Nonpathogen - hypothetical protein Mevan_0622 2 None None None 150400326 Common - indolepyruvate oxidoreductase subunit B Mevan_1589 83 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 150400391 Nonpathogen - hypothetical protein Mevan_1654 1 None None None 150399980 Common - DNA alkylation repair enzyme Mevan_1238 28 COG4912 COG4912, Predicted DNA alkylation repair enzyme DNA replication, recombination, and repair 150399700 Common - proteasome-activating nucleotidase Mevan_0952 249 COG1222 RPT1, ATP-dependent 26S proteasome regulatory subunit Posttranslational modification, protein turnover, chaperones 150399647 Common - putative agmatinase Mevan_0897 147 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 150400069 Common - thiamine pyrophosphate protein domain protein TPP-binding Mevan_1327 130 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 150398879 Common - hypothetical protein Mevan_0122 3 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 150398842 Common - seryl-tRNA synthetase-like protein Mevan_0083 11 COG4443 COG4443, Uncharacterized protein conserved in bacteria Function unknown 150398932 Nonpathogen - hypothetical protein Mevan_0176 26 COG2522 COG2522, Predicted transcriptional regulator General function prediction only 150398850 Common - heat shock protein DnaJ domain protein Mevan_0091 46 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 150400127 Nonpathogen - GHMP kinase Mevan_1385 30 COG1829 COG1829, Predicted archaeal kinase (sugar kinase superfamily) General function prediction only 150400162 Common - RimK domain protein ATP-grasp Mevan_1421 72 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 150398937 Nonpathogen - hypothetical protein Mevan_0181 8 COG4827 COG4827, Predicted transporter General function prediction only 150399463 Nonpathogen ef1B elongation factor 1-beta Mevan_0712 14 COG2092 EFB1, Translation elongation factor EF-1beta Translation, ribosomal structure and biogenesis 150400138 Common - H+-transporting two-sector ATPase, A subunit Mevan_1396 10 COG3367 COG3367, Uncharacterized conserved protein Function unknown 150398864 Common - CRISPR-associated protein, Crm2 family Mevan_0106 16 COG1353 COG1353, Predicted hydrolase of the HD superfamily (permuted catalytic motifs) General function prediction only 150399039 Nonpathogen - hypothetical protein Mevan_0285 5 COG3373 COG3373, Uncharacterized protein conserved in archaea Function unknown 150400157 Common - beta-lactamase domain protein Mevan_1416 165 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 150400192 Common - anaerobic ribonucleoside-triphosphate reductase activating protein Mevan_1453 93 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 150400268 Common - putative ATP binding related protein Mevan_1529 26 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 150398902 Common - formylmethanofuran dehydrogenase subunit E region Mevan_0146 37 COG2191 COG2191, Formylmethanofuran dehydrogenase subunit E Energy production and conversion 150399396 Common - GTP-binding protein HSR1-related Mevan_0645 110 COG1161 COG1161, Predicted GTPases General function prediction only 150399346 Nonpathogen - hypothetical protein Mevan_0595 4 COG3233 COG3233, Predicted deacetylase General function prediction only 150399758 Nonpathogen rps27e 30S ribosomal protein S27e Mevan_1010 33 COG2051 RPS27A, Ribosomal protein S27E Translation, ribosomal structure and biogenesis 150399489 Common - hypothetical protein Mevan_0738 48 COG2848 COG2848, Uncharacterized conserved protein Function unknown 150400420 Common - arsenical-resistance protein Mevan_1683 130 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 150398945 Nonpathogen - hypothetical protein Mevan_0189 2 None None None 150399556 Common pheS phenylalanyl-tRNA synthetase subunit alpha Mevan_0805 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 150398857 Nonpathogen - hypothetical protein Mevan_0098 3 None None None 150399567 Common - pyruvate ferredoxin oxidoreductase subunit gamma Mevan_0816 72 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 150399855 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_1110 155 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 150399216 Common - metallophosphoesterase Mevan_0464 37 COG1407 COG1407, Predicted ICC-like phosphoesterases General function prediction only 150400228 Nonpathogen - domain of unknown function DUF1743 Mevan_1489 33 COG1571 COG1571, Predicted DNA-binding protein containing a Zn-ribbon domain General function prediction only 150400279 Common ilvH acetolactate synthase 3 regulatory subunit Mevan_1542 194 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 150399870 Nonpathogen - nucleic acid binding OB-fold tRNA/helicase-type Mevan_1125 3 COG3390 COG3390, Uncharacterized protein conserved in archaea Function unknown 150400377 Nonpathogen - DNA replication protein; MCM family; putative Mevan_1640 5 COG1241 MCM2, Predicted ATPase involved in replication control, Cdc46/Mcm family DNA replication, recombination, and repair 150398777 Common - selenophosphate synthetase Mevan_0017 140 COG0709 SelD, Selenophosphate synthase Amino acid transport and metabolism 150399100 Common - aspartate kinase Mevan_0346 236 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 150399715 Nonpathogen - flagellin protein Mevan_0967 9 COG1681 FlaB, Archaeal flagellins Cell motility and secretion 150400366 Common - DEAD/DEAH box helicase domain protein Mevan_1629 242 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 150400172 Nonpathogen - hypothetical protein Mevan_1431 1 None None None 150399821 Nonpathogen - translation initiation factor IF-6 Mevan_1076 32 COG1976 TIF6, Translation initiation factor 6 (eIF-6) Translation, ribosomal structure and biogenesis 150400062 Common - DsrE family protein Mevan_1320 37 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 150399472 Common rpl24p 50S ribosomal protein L24P Mevan_0721 35 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 150399162 Common - Orn/DAP/Arg decarboxylase 2 Mevan_0409 158 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 150399515 Nonpathogen - hypothetical protein Mevan_0764 8 COG4037 COG4037, Predicted membrane protein Function unknown 150398966 Common - asparagine synthase (glutamine-hydrolyzing) Mevan_0211 172 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 150399613 Common - Xylose isomerase domain protein TIM barrel Mevan_0863 44 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 150399912 Common - sirohydrochlorin cobaltochelatase Mevan_1169 59 COG2138 COG2138, Uncharacterized conserved protein Function unknown 150399317 Common - putative signal-transduction protein with CBS domains Mevan_0565 168 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 150399725 Common - (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase Mevan_0977 52 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 150399183 Common - succinyl-CoA synthetase, beta subunit Mevan_0430 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 150399830 Common - Hydantoinase/oxoprolinase Mevan_1085 24 COG1548 COG1548, Predicted transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 150399004 Common - HAD superfamily (subfamily IA) hydrolase, TIGR02253 Mevan_0250 114 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 150399947 Common - hypothetical protein Mevan_1204 16 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 150399198 Common - Radical SAM domain protein Mevan_0446 71 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 150399138 Common - 2-isopropylmalate synthase Mevan_0385 225 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 150399772 Common - imidazoleglycerol phosphate synthase, cyclase subunit Mevan_1024 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 150399351 Common - GTP-binding protein Mevan_0600 161 COG0218 COG0218, Predicted GTPase General function prediction only 150399117 Nonpathogen - V-type ATP synthase subunit K Mevan_0363 2 None None None 150399153 Common - Phosphoglucosamine mutase Mevan_0400 243 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 150399142 Common - putative molybdenum cofactor biosynthesis protein C Mevan_0389 196 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 150400249 Common - hypothetical protein Mevan_1510 18 None None None 150400357 Common - transcriptional regulator, TetR family Mevan_1620 75 COG1309 AcrR, Transcriptional regulator Transcription 150400086 Common - ATPase, P-type (transporting), HAD superfamily, subfamily IC Mevan_1344 232 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 150399744 Common - nickel-dependent hydrogenase large subunit Mevan_0996 102 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 150399193 Common - Cellulase Mevan_0441 92 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 150400102 Nonpathogen - F420-dependent methylenetetrahydromethanopterin dehydrogenase Mevan_1360 15 COG1927 Mtd, Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase Energy production and conversion 150399935 Common - hypothetical protein Mevan_1192 7 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 150399421 Nonpathogen rpoH DNA-directed RNA polymerase subunit H Mevan_0670 33 COG2012 RPB5, DNA-directed RNA polymerase, subunit H, RpoH/RPB5 Transcription 150399431 Common - elongation factor 1-alpha Mevan_0680 249 COG5256 TEF1, Translation elongation factor EF-1alpha (GTPase) Translation, ribosomal structure and biogenesis 150400282 Common - RNA 3'-terminal-phosphate cyclase Mevan_1545 47 COG0430 RCL1, RNA 3'-terminal phosphate cyclase RNA processing and modification 150399525 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0774 117 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 150399428 Common rps12P 30S ribosomal protein S12P Mevan_0677 154 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 150400231 Common - protein of unknown function DUF134 Mevan_1492 36 COG1342 COG1342, Predicted DNA-binding proteins General function prediction only 150399110 Nonpathogen - hypothetical protein Mevan_0356 1 None None None 150398885 Common - transport system permease protein Mevan_0129 190 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 150399107 Nonpathogen - protein of unknown function DUF106 transmembrane Mevan_0353 8 COG1422 COG1422, Predicted membrane protein Function unknown 150398954 Common - glycosyl transferase group 1 Mevan_0199 228 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 150399336 Common - 2-ketoisovalerate ferredoxin reductase Mevan_0584 124 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 150399032 Common - cell surface protein Mevan_0278 26 None None None 150399176 Common - phosphate ABC transporter, ATPase subunit Mevan_0423 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 150399040 Nonpathogen - hypothetical protein Mevan_0286 1 None None None 150399236 Common - Heavy metal transport/detoxification protein Mevan_0484 9 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 150399071 Common - hypothetical protein Mevan_0317 68 COG1691 COG1691, NCAIR mutase (PurE)-related proteins General function prediction only 150398831 Nonpathogen - methyl-viologen-reducing hydrogenase delta subunit Mevan_0072 32 COG1908 FrhD, Coenzyme F420-reducing hydrogenase, delta subunit Energy production and conversion 150400289 Common - transporter, putative Mevan_1552 4 None None None 150399104 Common argS arginyl-tRNA synthetase Mevan_0350 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150400400 Common - Formylmethanofuran dehydrogenase Mevan_1663 62 COG2218 FwdC, Formylmethanofuran dehydrogenase subunit C Energy production and conversion 150399840 Common - coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein Mevan_1095 27 COG1035 FrhB, Coenzyme F420-reducing hydrogenase, beta subunit Energy production and conversion 150399229 Common - Desulfoferrodoxin ferrous iron-binding region Mevan_0477 24 COG2033 COG2033, Desulfoferrodoxin Energy production and conversion 150399847 Common - glycosyl transferase group 1 Mevan_1102 226 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 150398915 Nonpathogen - hypothetical protein Mevan_0159 1 None None None 150399301 Common - molybdopterin biosynthesis MoaE protein Mevan_0549 155 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 150399763 Nonpathogen - hypothetical protein Mevan_1015 6 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 150400320 Common - UDP-N-acetylglucosamine 2-epimerase Mevan_1583 156 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 150398785 Common - TPR repeat-containing protein Mevan_0025 25 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 150399350 Nonpathogen rpl10e 50S ribosomal protein L10e Mevan_0599 34 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 150399460 Common - succinyl-diaminopimelate desuccinylase Mevan_0709 200 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 150399244 Common - peroxiredoxin Mevan_0492 212 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 150398927 Common - O-acetylhomoserine/O-acetylserine sulfhydrylase Mevan_0171 207 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 150399046 Nonpathogen - hypothetical protein Mevan_0292 1 None None None 150399279 Common - acetyl-CoA acetyltransferase Mevan_0527 141 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 150398775 Common - ribonuclease Z Mevan_0015 117 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 150400438 Nonpathogen - phosphoesterase RecJ domain protein Mevan_1701 27 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 150399631 Nonpathogen - hypothetical protein Mevan_0881 3 COG4010 COG4010, Uncharacterized protein conserved in archaea Function unknown 150399521 Nonpathogen - hypothetical protein Mevan_0770 2 COG4035 COG4035, Predicted membrane protein Function unknown 150399400 Nonpathogen - hypothetical protein Mevan_0649 1 None None None 150400399 Common - Amidohydrolase 3 Mevan_1662 39 COG1229 FwdA, Formylmethanofuran dehydrogenase subunit A Energy production and conversion 150400098 Common - 2-hydroxyglutaryl-CoA dehydratase D-component Mevan_1356 37 COG1775 HgdB, Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB Amino acid transport and metabolism 150400018 Common - tyrosyl-tRNA synthetase Mevan_1276 166 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150399034 Common - signal transduction histidine kinase, LytS Mevan_0280 14 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 150399057 Common - Cobyrinic acid ac-diamide synthase Mevan_0303 92 COG3640 CooC, CO dehydrogenase maturation factor Cell division and chromosome partitioning 150399234 Common - beta-lactamase domain protein Mevan_0482 82 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 150399416 Common - transferase hexapeptide repeat protein Mevan_0665 150 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 150398909 Common - hypothetical protein Mevan_0153 4 None None None 150399409 Nonpathogen - Transcription factor CBF/NF-Y histone Mevan_0658 24 COG2036 HHT1, Histones H3 and H4 Chromatin structure and dynamics 150400053 Nonpathogen - Protein of unknown function DUF54 Mevan_1311 22 COG1325 COG1325, Predicted exosome subunit Translation, ribosomal structure and biogenesis 150399241 Common - SufBD protein Mevan_0489 188 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 150400426 Common - MscS Mechanosensitive ion channel Mevan_1689 230 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 150399511 Nonpathogen - hypothetical protein Mevan_0760 8 COG4041 COG4041, Predicted membrane protein Function unknown 150398838 Common - type I restriction-modification system, M subunit Mevan_0079 159 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 150399490 Nonpathogen - hypothetical protein Mevan_0739 1 None None None 150399496 Nonpathogen nusG transcription antitermination protein NusG Mevan_0745 34 COG0250 NusG, Transcription antiterminator Transcription 150399188 Nonpathogen - Protein of unknown function DUF70 Mevan_0436 6 COG1822 COG1822, Predicted archaeal membrane protein Function unknown 150398908 Common - helicase domain protein Mevan_0152 107 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 150399962 Common - L-seryl-tRNA selenium transferase Mevan_1219 11 COG1921 SelA, Selenocysteine synthase [seryl-tRNASer selenium transferase] Amino acid transport and metabolism 150400319 Common - Cobyrinic acid ac-diamide synthase Mevan_1582 229 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 150399126 Nonpathogen - multiple resistance and pH regulation protein F Mevan_0372 3 None None None 150399422 Common - DNA-directed RNA polymerase subunit beta'' Mevan_0671 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 150398804 Common cofG FO synthase subunit 1 Mevan_0044 57 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 150399257 Common - ribose 5-phosphate isomerase Mevan_0505 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 150399834 Nonpathogen - deoxyribonuclease/rho motif-related TRAM Mevan_1089 10 COG3269 COG3269, Predicted RNA-binding protein, contains TRAM domain General function prediction only 150400331 Common - putative transcriptional regulator, CopG family Mevan_1594 34 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 150399907 Nonpathogen rpl39e 50S ribosomal protein L39e Mevan_1164 3 COG2167 RPL39, Ribosomal protein L39E Translation, ribosomal structure and biogenesis 150399250 Common - transport system permease protein Mevan_0498 192 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 150399365 Common - response regulator receiver protein Mevan_0614 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 150399211 Common - putative transcriptional regulator, AsnC family Mevan_0459 162 COG1522 Lrp, Transcriptional regulators Transcription 150399789 Nonpathogen - type II secretion system protein Mevan_1042 3 COG1955 FlaJ, Archaeal flagella assembly protein J Cell motility and secretion / Intracellular trafficking and secretion 150399883 Common - inosine-5'-monophosphate dehydrogenase Mevan_1138 242 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 150399237 Common - heavy metal translocating P-type ATPase Mevan_0485 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 150399167 Common - polysaccharide biosynthesis protein Mevan_0414 63 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 150399287 Common - alpha-glucan phosphorylase Mevan_0535 85 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 150399147 Nonpathogen - Protein of unknown function DUF54 Mevan_0394 23 COG1931 COG1931, Uncharacterized protein conserved in archaea Function unknown 150399993 Nonpathogen - hypothetical protein Mevan_1251 2 None None None 150398872 Common - CRISPR-associated protein Cas1 Mevan_0114 101 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 150399064 Nonpathogen - acetyl-CoA decarbonylase/synthase complex subunit epsilon Mevan_0310 10 COG1880 CdhB, CO dehydrogenase/acetyl-CoA synthase epsilon subunit Energy production and conversion 150400340 Common xseA exodeoxyribonuclease VII large subunit Mevan_1603 205 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 150399659 Nonpathogen - phosphatidylglycerophosphatase A Mevan_0909 15 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 150399582 Common - ABC transporter related Mevan_0831 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 150400096 Nonpathogen - hypothetical protein Mevan_1354 1 None None None 150400203 Common - cell division ATPase MinD Mevan_1464 190 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 150399683 Nonpathogen - hypothetical protein Mevan_0934 1 None None None 150400307 Common - O-phosphoseryl-tRNA synthetase Mevan_1570 56 COG2024 COG2024, Phenylalanyl-tRNA synthetase alpha subunit (archaeal type) Translation, ribosomal structure and biogenesis 150399742 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0994 136 COG2768 COG2768, Uncharacterized Fe-S center protein General function prediction only 150399291 Common - geranylgeranyl reductase Mevan_0539 78 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 150399749 Nonpathogen - hypothetical protein Mevan_1001 4 None None None 150399201 Common - putative RNA methylase, NOL1/NOP2/sun family Mevan_0449 205 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 150399638 Nonpathogen - hypothetical protein Mevan_0888 1 None None None 150400409 Nonpathogen - hypothetical protein Mevan_1672 2 None None None 150399608 Nonpathogen rpl4lp 50S ribosomal protein L4P Mevan_0858 34 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 150399956 Common - geranylgeranylglyceryl phosphate synthase-like protein Mevan_1213 26 COG1646 COG1646, Predicted phosphate-binding enzymes, TIM-barrel fold General function prediction only 150399554 Common - protein of unknown function DUF366 Mevan_0803 16 COG2029 COG2029, Uncharacterized conserved protein Function unknown 150399589 Common - peptidase U62 modulator of DNA gyrase Mevan_0838 159 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 150399649 Common - protein of unknown function DUF6 transmembrane Mevan_0899 5 COG2510 COG2510, Predicted membrane protein Function unknown 150400296 Nonpathogen - hypothetical protein Mevan_1559 27 COG4880 COG4880, Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats General function prediction only 150400022 Common truA tRNA pseudouridine synthase A Mevan_1280 125 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 150399274 Nonpathogen - 30S ribosomal protein S6e Mevan_0522 34 COG2125 RPS6A, Ribosomal protein S6E (S10) Translation, ribosomal structure and biogenesis 150399696 Nonpathogen - hypothetical protein Mevan_0948 2 COG2450 COG2450, Uncharacterized conserved protein Function unknown 150398781 Common - Rhodanese domain protein Mevan_0021 64 COG2603 COG2603, Predicted ATPase General function prediction only 150398990 Common - precorrin-3B C17-methyltransferase Mevan_0236 125 COG1010 CobJ, Precorrin-3B methylase Coenzyme metabolism 150399545 Common - molybdenum cofactor synthesis domain Mevan_0794 177 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 150400153 Common rfc replication factor C small subunit Mevan_1412 249 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 150400201 Nonpathogen - hypothetical protein Mevan_1462 2 None None None 150399650 Common - D-3-phosphoglycerate dehydrogenase Mevan_0900 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 150400076 Nonpathogen - protein of unknown function Met10 Mevan_1334 35 COG2520 COG2520, Predicted methyltransferase General function prediction only 150399269 Common - protein of unknown function UPF0066 Mevan_0517 59 COG1720 COG1720, Uncharacterized conserved protein Function unknown 150398999 Common - protein of unknown function UPF0118 Mevan_0245 129 COG0628 PerM, Predicted permease General function prediction only 150400188 Common - dihydrodipicolinate synthase Mevan_1449 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 150399921 Common - metal dependent phosphohydrolase Mevan_1178 88 COG1078 COG1078, HD superfamily phosphohydrolases General function prediction only 150400005 Nonpathogen - Shwachman-Bodian-Diamond syndrome protein Mevan_1263 34 COG1500 COG1500, Predicted exosome subunit Translation, ribosomal structure and biogenesis 150400401 Common - molybdenum containing formylmethanofuran dehydrogenase, subunit B Mevan_1664 140 COG1029 FwdB, Formylmethanofuran dehydrogenase subunit B Energy production and conversion 150399375 Common - phosphoesterase RecJ domain protein Mevan_0624 27 COG1107 COG1107, Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain DNA replication, recombination, and repair 150399699 Nonpathogen - helix-turn-helix domain protein Mevan_0951 31 COG1813 COG1813, Predicted transcription factor, homolog of eukaryotic MBF1 Transcription 150400067 Common - Phenylacetate--CoA ligase Mevan_1325 115 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 150399782 Common - metal dependent phosphohydrolase Mevan_1034 24 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 150399465 Common rpl22p 50S ribosomal protein L22P Mevan_0714 76 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 150399733 Nonpathogen - hypothetical protein Mevan_0985 1 COG1991 COG1991, Uncharacterized conserved protein Function unknown 150400265 Nonpathogen - hypothetical protein Mevan_1526 7 COG4066 COG4066, Uncharacterized protein conserved in archaea Function unknown 150400024 Nonpathogen - Fe-S cluster domain protein Mevan_1282 16 COG2000 COG2000, Predicted Fe-S protein General function prediction only 150400136 Nonpathogen - putative TIM-barrel protein Mevan_1394 14 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 150400155 Nonpathogen - protein of unknown function DUF211 Mevan_1414 23 COG1888 COG1888, Uncharacterized protein conserved in archaea Function unknown 150399353 Common - glycoside hydrolase 15-related Mevan_0602 30 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 150400349 Common - methionine-R-sulfoxide reductase Mevan_1612 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 150399594 Nonpathogen - hypothetical protein Mevan_0843 2 None None None 150398840 Common - putative transcriptional regulator Mevan_0081 54 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 150400104 Nonpathogen - hypothetical protein Mevan_1362 25 COG1439 COG1439, Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module General function prediction only 150399155 Common - glycosyl transferase family 2 Mevan_0402 180 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 150399048 Common - adenylosuccinate lyase Mevan_0294 241 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 150400311 Common - prolyl-tRNA synthetase Mevan_1574 237 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 150399226 Common - CoB--CoM heterodisulfide reductase Mevan_0474 45 COG1150 HdrC, Heterodisulfide reductase, subunit C Energy production and conversion 150398810 Common - CMP/dCMP deaminase zinc-binding Mevan_0051 210 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 150398852 Common - 2-alkenal reductase Mevan_0093 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 150400332 Common - hydroxylamine reductase Mevan_1595 75 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 150399090 Common - dihydroorotase, multifunctional complex type Mevan_0336 213 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 150400223 Common - 2'-5' RNA ligase Mevan_1484 84 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 150398972 Common - hypothetical protein Mevan_0217 24 COG1901 COG1901, Uncharacterized conserved protein Function unknown 150399527 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0776 153 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 150398930 Common - nitrogen-fixing NifU domain protein Mevan_0174 163 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 150399018 Common - restriction modification system DNA specificity domain Mevan_0264 77 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 150398859 Nonpathogen - hypothetical protein Mevan_0100 1 None None None 150399165 Common - NAD-dependent epimerase/dehydratase Mevan_0412 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 150399218 Common - Bacitracin resistance protein BacA Mevan_0466 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 150400047 Common - Pyrrolo-quinoline quinone Mevan_1305 51 COG1520 COG1520, FOG: WD40-like repeat Function unknown 150399872 Nonpathogen - hypothetical protein Mevan_1127 4 None None None 150399264 Common - binding-protein-dependent transport systems inner membrane component Mevan_0512 211 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 150399304 Common - biotin synthase Mevan_0552 175 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 150399483 Common rpl15p 50S ribosomal protein L15P Mevan_0732 34 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 150400221 Common - archaeosine tRNA-ribosyltransferase Mevan_1482 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 150399097 Nonpathogen - Transcription factor CBF/NF-Y histone Mevan_0343 2 COG2036 HHT1, Histones H3 and H4 Chromatin structure and dynamics 150399836 Nonpathogen - orotate phosphoribosyltransferase Mevan_1091 19 COG0856 COG0856, Orotate phosphoribosyltransferase homologs Nucleotide transport and metabolism 150399905 Nonpathogen - hypothetical protein Mevan_1162 33 COG2118 COG2118, DNA-binding protein General function prediction only 150398794 Common - cobalt ABC transporter, inner membrane subunit CbiQ Mevan_0034 62 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 150399738 Nonpathogen - hypothetical protein Mevan_0990 2 None None None 150400364 Nonpathogen - hypothetical protein Mevan_1627 2 None None None 150398773 Common - putative signal transduction protein with CBS domains Mevan_0013 78 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 150400380 Common - hypothetical protein Mevan_1643 2 None None None 150399578 Common - prephenate dehydrogenase Mevan_0827 174 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 150400145 Common - O-sialoglycoprotein endopeptidase/protein kinase Mevan_1404 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 150399779 Common - protein of unknown function DUF198 Mevan_1031 62 COG1469 COG1469, Uncharacterized conserved protein Function unknown 150398988 Nonpathogen - hypothetical protein Mevan_0234 5 None None None 150399964 Common - sodium/hydrogen exchanger Mevan_1221 204 COG4651 RosB, Kef-type K+ transport system, predicted NAD-binding component Inorganic ion transport and metabolism 150399459 Common - chromosome segregation protein SMC Mevan_0708 209 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 150399983 Common - anaerobic ribonucleoside-triphosphate reductase Mevan_1241 106 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 150400305 Nonpathogen - FeoA family protein Mevan_1568 8 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 150399323 Common - delta-aminolevulinic acid dehydratase Mevan_0571 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 150399174 Common - phosphate ABC transporter, inner membrane subunit PstC Mevan_0421 225 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 150399668 Common - tetrahydromethanopterin formyltransferase Mevan_0919 24 COG2037 Ftr, Formylmethanofuran:tetrahydromethanopterin formyltransferase Energy production and conversion 150399970 Common - glycyl-tRNA synthetase Mevan_1227 90 COG0423 GRS1, Glycyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 150400354 Common - hypothetical protein Mevan_1617 10 None None None 150398769 Common - 4-oxalocrotonate tautomerase Mevan_0009 9 COG1942 COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog General function prediction only 150399814 Common - putative methylase Mevan_1069 186 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 150398866 Common - CRISPR-associated RAMP protein, Cmr4 family Mevan_0108 29 COG1336 COG1336, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 150400431 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase Mevan_1694 152 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 150399637 Common - 6-carboxyhexanoate--CoA ligase Mevan_0887 8 COG1424 BioW, Pimeloyl-CoA synthetase Coenzyme metabolism 150400274 Nonpathogen - hypothetical protein Mevan_1536 10 COG4051 COG4051, Uncharacterized protein conserved in archaea Function unknown 150398817 Nonpathogen - Dinitrogenase iron-molybdenum cofactor biosynthesis protein Mevan_0058 26 COG1433 COG1433, Uncharacterized conserved protein Function unknown 150399979 Common - glutamate-1-semialdehyde aminotransferase Mevan_1237 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 150398882 Common - Magnesium chelatase Mevan_0125 78 COG1239 ChlI, Mg-chelatase subunit ChlI Coenzyme metabolism 150399656 Nonpathogen - hypothetical protein Mevan_0906 2 None None None 150399284 Nonpathogen - hypothetical protein Mevan_0532 4 COG4024 COG4024, Uncharacterized protein conserved in archaea Function unknown 150399164 Common - glycosyl transferase group 1 Mevan_0411 208 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 150399195 Nonpathogen - hypothetical protein Mevan_0443 3 None None None 150399455 Nonpathogen - Protein of unknown function DUF371 Mevan_0704 27 COG2090 COG2090, Uncharacterized protein conserved in archaea Function unknown 150399897 Common - putative RNA methylase Mevan_1154 49 COG1041 COG1041, Predicted DNA modification methylase DNA replication, recombination, and repair 150400247 Common - heat shock protein Hsp20 Mevan_1508 64 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 150400088 Nonpathogen - hypothetical protein Mevan_1346 2 None None None 150399602 Common - transporter component Mevan_0851 12 None None None 150400174 Common - CBS domain containing protein Mevan_1434 99 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 150400359 Common - ribonuclease H Mevan_1622 18 COG3341 COG3341, Predicted double-stranded RNA/RNA-DNA hybrid binding protein General function prediction only 150399348 Nonpathogen - Protein of unknown function UPF0058 Mevan_0597 16 COG1745 COG1745, Predicted metal-binding protein General function prediction only 150399144 Common - Na+/Ca+ antiporter, CaCA family Mevan_0391 101 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 150399611 Common rps19p 30S ribosomal protein S19P Mevan_0861 146 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 150399933 Nonpathogen - diphthamide biosynthesis protein Mevan_1190 34 COG1736 DPH2, Diphthamide synthase subunit DPH2 Translation, ribosomal structure and biogenesis 150399002 Common - hypothetical protein Mevan_0248 92 COG5270 COG5270, PUA domain (predicted RNA-binding domain) Translation, ribosomal structure and biogenesis 150399119 Common - V-type ATP synthase subunit C Mevan_0365 32 COG1527 NtpC, Archaeal/vacuolar-type H+-ATPase subunit C Energy production and conversion 150399023 Nonpathogen - hypothetical protein Mevan_0269 1 None None None 150399706 Nonpathogen - 30S ribosomal protein S8e Mevan_0958 34 COG2007 RPS8A, Ribosomal protein S8E Translation, ribosomal structure and biogenesis 150399756 Nonpathogen - H/ACA RNA-protein complex component Nop10p Mevan_1008 21 COG2260 COG2260, Predicted Zn-ribbon RNA-binding protein Translation, ribosomal structure and biogenesis 150399112 Nonpathogen - protein of unknown function DUF107 Mevan_0358 15 COG1030 NfeD, Membrane-bound serine protease (ClpP class) Posttranslational modification, protein turnover, chaperones 150398847 Common - Resolvase domain Mevan_0088 142 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 150398899 Common - iron-containing alcohol dehydrogenase Mevan_0143 173 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 150399009 Nonpathogen - Protein of unknown function DUF439 Mevan_0255 9 COG2469 COG2469, Uncharacterized conserved protein Function unknown 150399411 Common - NAD+ synthetase Mevan_0660 225 COG0171 NadE, NAD synthase Coenzyme metabolism 150398918 Common - aldehyde dehydrogenase Mevan_0162 219 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 150400428 Common - DNA-(apurinic or apyrimidinic site) lyase Mevan_1691 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 150398792 Nonpathogen - cobalt transport protein CbiN Mevan_0032 8 None None None 150400379 Nonpathogen - hypothetical protein Mevan_1642 1 None None None 150399311 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Mevan_0559 170 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 150399861 Common - hypothetical protein Mevan_1116 2 None None None 150399334 Common - bifunctional hexulose-6-phosphate synthase/ribonuclease regulator Mevan_0582 128 COG0269 SgbH, 3-hexulose-6-phosphate synthase and related proteins Carbohydrate transport and metabolism 150399123 Common - V-type ATP synthase subunit D Mevan_0369 44 COG1394 NtpD, Archaeal/vacuolar-type H+-ATPase subunit D Energy production and conversion 150399102 Common - MCM family protein Mevan_0348 46 COG1241 MCM2, Predicted ATPase involved in replication control, Cdc46/Mcm family DNA replication, recombination, and repair 150398892 Common - transcriptional regulator, MarR family Mevan_0136 53 COG1846 MarR, Transcriptional regulators Transcription 150399710 Common - precorrin-4 C11-methyltransferase Mevan_0962 203 COG2875 CobM, Precorrin-4 methylase Coenzyme metabolism 150399569 Nonpathogen - Protein of unknown function DUF357 Mevan_0818 15 COG1849 COG1849, Uncharacterized protein conserved in archaea Function unknown 150400255 Nonpathogen - hypothetical protein Mevan_1516 3 COG4854 COG4854, Predicted membrane protein Function unknown 150400254 Nonpathogen - hypothetical protein Mevan_1515 11 COG4090 COG4090, Uncharacterized protein conserved in archaea Function unknown 150399717 Nonpathogen - Flagella accessory C family protein Mevan_0969 7 COG3352 FlaC, Putative archaeal flagellar protein C Cell motility and secretion 150399721 Nonpathogen - flagella protein G Mevan_0973 9 COG3354 FlaG, Putative archaeal flagellar protein G Cell motility and secretion 150400421 Common - redox-active disulfide protein 2 Mevan_1684 64 None None None 150399783 Nonpathogen - type II secretion system protein Mevan_1035 4 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 150398762 Common - Imidazoleglycerol-phosphate dehydratase Mevan_0002 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 150399702 Common - hypothetical protein Mevan_0954 26 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 150399728 Common - glucosamine--fructose-6-phosphate aminotransferase, isomerizing Mevan_0980 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 150400370 Common - DNA-cytosine methyltransferase Mevan_1633 133 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 150399626 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit B Mevan_0876 8 COG4062 MtrB, Tetrahydromethanopterin S-methyltransferase, subunit B Coenzyme metabolism 150399020 Nonpathogen - hypothetical protein Mevan_0266 6 COG1673 COG1673, Uncharacterized protein conserved in archaea Function unknown 150399949 Common - hypothetical protein Mevan_1206 3 None None None 150400287 Common - protein of unknown function DUF354 Mevan_1550 23 COG1817 COG1817, Uncharacterized protein conserved in archaea Function unknown 150400182 Common - hypothetical protein Mevan_1443 47 COG0824 FcbC, Predicted thioesterase General function prediction only 150399790 Common - type II secretion system protein E Mevan_1043 223 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 150400040 Nonpathogen - hypothetical protein Mevan_1298 2 COG1531 COG1531, Uncharacterized protein conserved in archaea Function unknown 150399723 Common - type II secretion system protein E Mevan_0975 225 COG0630 VirB11, Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis Cell motility and secretion / Intracellular trafficking and secretion 150399770 Nonpathogen - hypothetical protein Mevan_1022 2 None None None 150399089 Nonpathogen - hypothetical protein Mevan_0335 2 None None None