Methanobrevibacter smithii ATCC 35061, complete genome NC_009515 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 148642199 Nonpathogen - hypothetical protein Msm_0139 1 None None None 148643661 Nonpathogen - hypothetical protein Msm_1601 1 None None None 148642478 Common - hypothetical protein Msm_0418 96 COG0393 COG0393, Uncharacterized conserved protein Function unknown 148643022 Nonpathogen - glyceraldehyde-3-phosphate dehydrogenase Msm_0962 39 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 148642955 Common - cation transport ATPase, HAD family Msm_0895 232 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 148642461 Nonpathogen - predicted surface protease Msm_0401 2 None None None 148642141 Common - sulfopyruvate decarboxylase, ComE Msm_0081 47 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 148643771 Common - hypothetical protein Msm_1711 6 None None None 148642686 Common - cell division protein FtsZ Msm_0626 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 148642491 Nonpathogen - predicted ATP-dependent carboligase, biotin carboxylase-related Msm_0431 15 COG2232 COG2232, Predicted ATP-dependent carboligase related to biotin carboxylase General function prediction only 148642446 Common - sodium/proline symporter (proline permease), PutP Msm_0386 187 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 148642097 Nonpathogen - hypothetical protein Msm_0037 1 None None None 148642150 Nonpathogen - hypothetical protein Msm_0090 16 COG1745 COG1745, Predicted metal-binding protein General function prediction only 148643497 Common rps2P 30S ribosomal protein S2 Msm_1437 126 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 148642485 Nonpathogen - H/ACA RNA-protein complex component Gar1 Msm_0425 6 COG3277 GAR1, RNA-binding protein involved in rRNA processing Translation, ribosomal structure and biogenesis 148642302 Common - exosome complex exonuclease Rrp41 Msm_0242 233 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 148643304 Nonpathogen - predicted metal-dependent phosphoesterase, PHP family Msm_1244 29 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 148643535 Common - predicted endonuclease III-related protein Msm_1475 76 COG2231 COG2231, Uncharacterized protein related to Endonuclease III DNA replication, recombination, and repair 148642774 Nonpathogen - predicted GTPase Msm_0714 38 COG1163 DRG, Predicted GTPase General function prediction only 148642157 Common - Mg-dependent DNase, TatD Msm_0097 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 148642222 Nonpathogen - hypothetical protein Msm_0162 1 None None None 148643323 Common pyrB aspartate carbamoyltransferase catalytic subunit Msm_1263 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 148642640 Nonpathogen - putative adhesin-like protein Msm_0580 2 None None None 148642261 Nonpathogen - 30S ribosomal protein S6e Msm_0201 34 COG2125 RPS6A, Ribosomal protein S6E (S10) Translation, ribosomal structure and biogenesis 148642314 Nonpathogen - hypothetical protein Msm_0254 1 None None None 148642825 Common - pyruvate carboxylase subunit A Msm_0765 237 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 148642366 Common - polyferredoxin, iron-sulfur binding Msm_0306 89 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 148643419 Common - adenine phosphoribosyltransferase Msm_1359 140 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 148642424 Common - nickel responsive regulator Msm_0364 67 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 148643741 Nonpathogen - hypothetical protein Msm_1681 2 None None None 148642393 Common - 2-oxoisovalerate ferredoxin oxidoreductase, beta subunit Msm_0333 110 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 148643485 Common rps13p 30S ribosomal protein S13P Msm_1425 204 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 148643219 Common hisH imidazole glycerol phosphate synthase subunit HisH Msm_1159 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 148643189 Common - hypothetical protein Msm_1129 34 COG1379 COG1379, Uncharacterized conserved protein Function unknown 148642910 Common - hypothetical protein Msm_0850 35 COG4589 COG4589, Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase General function prediction only 148643341 Common - sirohydrochlorin cobaltochelatase Msm_1281 45 COG2138 COG2138, Uncharacterized conserved protein Function unknown 148643611 Common - glucosamine--fructose-6-phosphate aminotransferase, GlmS Msm_1551 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 148642380 Nonpathogen - predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaG Msm_0320 8 COG4036 COG4036, Predicted membrane protein Function unknown 148642375 Nonpathogen - predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaL Msm_0315 5 COG4035 COG4035, Predicted membrane protein Function unknown 148642530 Nonpathogen - hypothetical protein Msm_0470 1 None None None 148643469 Common - tungsten formylmethanofuran dehydrogenase, subunit F, FwdF Msm_1409 184 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 148643250 Common - cell wall biosynthesis protein, UDP-N-acetylmuramate-alanine ligase family Msm_1190 96 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 148642464 Nonpathogen - predicted transcriptional regulator Msm_0404 11 COG4742 COG4742, Predicted transcriptional regulator Transcription 148642470 Nonpathogen - hypothetical protein Msm_0410 3 None None None 148643203 Common - indole-3-glycerol phosphate synthase, TrpC Msm_1143 219 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 148643735 Common - putative structural protein (prophage psiM100) Msm_1675 5 None None None 148643572 Common - lipopolysaccharide cholinephosphotransferase, LicD family Msm_1512 16 COG3475 COG3475, LPS biosynthesis protein Cell envelope biogenesis, outer membrane 148642205 Nonpathogen - hypothetical protein Msm_0145 2 None None None 148642622 Common - formate dehydrogenase, iron-sulfur subunit Msm_0562 25 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 148643598 Common - CMP-sialic acid synthetase, NeuA Msm_1538 31 COG3980 spsG, Spore coat polysaccharide biosynthesis protein, predicted glycosyltransferase Cell envelope biogenesis, outer membrane 148643657 Nonpathogen - hypothetical protein Msm_1597 1 None None None 148642102 Nonpathogen - hypothetical protein Msm_0042 1 None None None 148642090 Common - hypothetical protein Msm_0030 59 COG1971 COG1971, Predicted membrane protein Function unknown 148643348 Common - hypothetical protein Msm_1288 11 COG5305 COG5305, Predicted membrane protein Function unknown 148642073 Nonpathogen - hypothetical protein Msm_0013 1 None None None 148643159 Nonpathogen - hypothetical protein Msm_1099 8 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 148642188 Nonpathogen - hypothetical protein Msm_0128 3 None None None 148642764 Nonpathogen - translation initiation factor IF-6 Msm_0704 33 COG1976 TIF6, Translation initiation factor 6 (eIF-6) Translation, ribosomal structure and biogenesis 148643600 Common - glycerol-3-phosphate dehydrogenase (NAD) Msm_1540 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 148643521 Nonpathogen - methyl viologen-reducing hydrogenase, delta subunit, MvhD Msm_1461 32 COG1908 FrhD, Coenzyme F420-reducing hydrogenase, delta subunit Energy production and conversion 148642250 Nonpathogen - predicted ATPase Msm_0190 8 COG1365 COG1365, Predicted ATPase (PP-loop superfamily) General function prediction only 148642919 Common - glycerol-3-phosphate cytidylyltransferase Msm_0859 85 COG0615 TagD, Cytidylyltransferase Cell envelope biogenesis, outer membrane / Lipid metabolism 148643003 Nonpathogen - hypothetical protein Msm_0943 1 None None None 148643191 Nonpathogen - hypothetical protein Msm_1131 31 COG2047 COG2047, Uncharacterized protein (ATP-grasp superfamily) General function prediction only 148642636 Common - NIF3-related protein (NGG1p interacting factor 3) Msm_0576 39 COG0327 COG0327, Uncharacterized conserved protein Function unknown 148643171 Common - adhesin-like protein Msm_1111 91 None None None 148643591 Common - Na+-dependent transporter, SNF family Msm_1531 88 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 148643630 Common - cell wall biosynthesis protein, MurD-like peptide ligase family Msm_1570 18 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 148642883 Common - phosphoenolpyruvate synthase/pyruvate phosphate dikinase, PpsA Msm_0823 19 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 148643781 Common - voltage gated chloride channel protein/cation transporter, TrkA family Msm_1721 159 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 148642931 Nonpathogen - putative transposase Msm_0871 4 None None None 148642582 Common - collagenase, peptidase family U32 Msm_0522 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 148643249 Nonpathogen - putative transposase Msm_1189 4 None None None 148643082 Nonpathogen - hypothetical protein Msm_1022 3 None None None 148643844 Nonpathogen - hypothetical protein Msm_1784 1 None None None 148643121 Nonpathogen - energy-converting hydrogenase B, subunit P, EhbP Msm_1061 5 None None None 148642387 Common - UDP-glucose 4-epimerase (NAD dependent) Msm_0327 234 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 148642579 Nonpathogen - hypothetical protein Msm_0519 4 None None None 148642293 Common - nitrogen regulatory protein P-II, GlnK Msm_0233 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 148642168 Common hypA hydrogenase nickel incorporation protein Msm_0108 99 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 148642257 Common - DNA-directed RNA polymerase subunit E' Msm_0197 95 COG1095 RPB7, DNA-directed RNA polymerase, subunit E' Transcription 148643410 Nonpathogen - predicted transcriptional regulator, ArsR family Msm_1350 17 COG1719 COG1719, Predicted hydrocarbon binding protein (contains V4R domain) General function prediction only 148643186 Common - predicted transcriptional regulator, ArsR family Msm_1126 123 COG0640 ArsR, Predicted transcriptional regulators Transcription 148642570 Nonpathogen - predicted ATPase involved in DNA replication control, MCM2/3/5 family Msm_0510 36 COG1241 MCM2, Predicted ATPase involved in replication control, Cdc46/Mcm family DNA replication, recombination, and repair 148643254 Nonpathogen rps15p 30S ribosomal protein S15P Msm_1194 34 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 148642799 Nonpathogen rpl15p 50S ribosomal protein L15P Msm_0739 34 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 148642525 Nonpathogen - hypothetical protein Msm_0465 3 COG1873 COG1873, Uncharacterized conserved protein Function unknown 148643753 Common - predicted ribokinase, PfkB family Msm_1693 11 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 148643609 Common - phosphoribosylformylglycinamidine (FGAM) synthase, PurQ Msm_1549 232 COG0047 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain Nucleotide transport and metabolism 148643222 Common - hypothetical protein Msm_1162 4 None None None 148643037 Nonpathogen - putative biopolymer transport protein, ExbD/TolR family Msm_0977 3 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 148643765 Common - predicted collagenase, peptidase family U32 Msm_1705 140 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 148642457 Common - xanthine/uracil permease, UraA Msm_0397 125 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 148643685 Common - thiol:fumarate reductase, subunit B, TfrB Msm_1625 169 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 148643376 Common - glycosyltransferase, GT2 family Msm_1316 175 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 148643448 Common - thiamine biosynthesis protein ThiC Msm_1388 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 148642204 Nonpathogen - hypothetical protein Msm_0144 1 None None None 148642966 Common - transcription elongation factor NusA-like protein Msm_0906 50 COG0195 NusA, Transcription elongation factor Transcription 148642856 Common - heterodisulfide reductase, subunit C, HdrC Msm_0796 39 COG1150 HdrC, Heterodisulfide reductase, subunit C Energy production and conversion 148643095 Common - FO synthase subunit 1 (SAM-dependent), CofG (F420 biosynthesis) Msm_1035 73 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 148643470 Nonpathogen - tungsten formylmethanofuran dehydrogenase, subunit G, FwdG Msm_1410 19 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 148642324 Common - cysteine desulfurase, NifS Msm_0264 239 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 148643545 Nonpathogen - putative adhesin-like protein Msm_1485 1 None None None 148643208 Common - predicted metal-dependent membrane protease Msm_1148 38 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 148643061 Nonpathogen - methyl viologen-reducing hydrogenase, delta subunit, MvhD Msm_1001 32 COG1908 FrhD, Coenzyme F420-reducing hydrogenase, delta subunit Energy production and conversion 148643458 Common - adhesin-like protein Msm_1398 28 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 148642994 Nonpathogen - predicted phosphatidylglycerophosphatase A-related protein Msm_0934 12 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 148643367 Common - dTDP-glucose pyrophosphorylase, RfbA Msm_1307 233 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 148642998 Nonpathogen - hypothetical protein Msm_0938 1 None None None 148643229 Nonpathogen - hypothetical protein Msm_1169 1 None None None 148643068 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit G Msm_1008 4 COG4064 MtrG, Tetrahydromethanopterin S-methyltransferase, subunit G Coenzyme metabolism 148643810 Common - hypothetical protein Msm_1750 17 None None None 148642344 Common - ribose 5-phosphate isomerase, RpiA Msm_0284 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 148643109 Common - phosphopantothenoylcysteine synthetase/decarboxylase Msm_1049 230 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 148642598 Common - pyruvate formate-lyase activating enzyme, PflA Msm_0538 36 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 148642117 Nonpathogen - adhesin-like protein Msm_0057 1 None None None 148643806 Common - predicted type II restriction enzyme, methylase subunit Msm_1746 21 None None None 148643412 Common - predicted ATP-dependent DNA helicase Msm_1352 44 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 148643670 Common - molybdate ABC transporter, permease component, ModC Msm_1610 226 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 148642868 Common - nitrogenase iron-molybdenum cofactor biosynthesis protein, NifB Msm_0808 109 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 148643035 Common - F420-0--gamma-glutamyl ligase Msm_0975 44 COG1478 COG1478, Uncharacterized conserved protein Function unknown 148642862 Common - methyltransferase Msm_0802 47 COG2520 COG2520, Predicted methyltransferase General function prediction only 148642660 Common - transcriptional regulator, MarR family Msm_0600 17 COG1846 MarR, Transcriptional regulators Transcription 148642913 Common - UDP-N-acetylglucosamine 2-epimerase, WecB Msm_0853 156 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 148643317 Nonpathogen - predicted transcriptional regulator of riboflavin/FAD biosynthetic operon Msm_1257 32 COG1339 COG1339, Transcriptional regulator of a riboflavin/FAD biosynthetic operon Transcription / Coenzyme metabolism 148643076 Nonpathogen - methyl-coenzyme M reductase, gamma subunit, McrG Msm_1016 14 COG4057 McrG, Methyl coenzyme M reductase, gamma subunit Coenzyme metabolism 148642545 Common - universal stress protein, UspA Msm_0485 171 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 148642709 Nonpathogen - hypothetical protein Msm_0649 4 COG1852 COG1852, Uncharacterized conserved protein Function unknown 148642215 Nonpathogen - predicted allosteric regulator of homoserine dehydrogenase Msm_0155 18 COG2061 COG2061, ACT-domain-containing protein, predicted allosteric regulator of homoserine dehydrogenase Amino acid transport and metabolism 148643045 Nonpathogen - hypothetical protein Msm_0985 20 COG2098 COG2098, Uncharacterized protein conserved in archaea Function unknown 148642473 Common - transcriptional regulator, MarR family Msm_0413 39 COG1846 MarR, Transcriptional regulators Transcription 148643817 Nonpathogen - hypothetical protein Msm_1757 1 None None None 148642400 Common - thioredoxin reductase (NADPH), TrxB Msm_0340 249 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 148643635 Nonpathogen - hypothetical protein Msm_1575 1 None None None 148643398 Common - flavoprotein Msm_1338 21 COG1036 COG1036, Archaeal flavoproteins Energy production and conversion 148643513 Nonpathogen - hypothetical protein Msm_1453 1 None None None 148643256 Common - predicted ATPase, AAA+ superfamily Msm_1196 26 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 148643802 Nonpathogen - predicted integrase, phage integrase-like family Msm_1742 3 None None None 148642345 Nonpathogen - hypothetical protein Msm_0285 23 COG1860 COG1860, Uncharacterized protein conserved in archaea Function unknown 148643557 Common - predicted coenzyme PQQ synthesis protein Msm_1497 84 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 148642970 Common - DNA-directed RNA polymerase subunit B' Msm_0910 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 148643562 Common - UDP-galactopyranose mutase Msm_1502 54 COG0562 Glf, UDP-galactopyranose mutase Cell envelope biogenesis, outer membrane 148643483 Common - exopolyphosphatase, GppA Msm_1423 181 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 148643834 Nonpathogen - hypothetical protein Msm_1774 1 None None None 148642613 Common - ATPase, PP-loop superfamily Msm_0553 159 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 148642415 Common - predicted transcription factor (eukaryotic MBF1 related) Msm_0355 34 COG1813 COG1813, Predicted transcription factor, homolog of eukaryotic MBF1 Transcription 148642810 Nonpathogen - ribosomal protein L24p Msm_0750 34 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 148643547 Nonpathogen - hypothetical protein Msm_1487 2 None None None 148642307 Nonpathogen - ribonuclease P protein component 3 Msm_0247 16 COG1603 RPP1, RNase P/RNase MRP subunit p30 Translation, ribosomal structure and biogenesis 148643146 Nonpathogen - hypothetical protein Msm_1086 10 COG4883 COG4883, Uncharacterized protein conserved in archaea Function unknown 148642816 Common rps3p 30S ribosomal protein S3P Msm_0756 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 148643306 Common - 2-isopropylmalate synthase Msm_1246 217 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 148642505 Common - NADH dehydrogenase/NAD(P)H nitroreductase Msm_0445 104 COG0778 NfnB, Nitroreductase Energy production and conversion 148642134 Nonpathogen - hypothetical protein Msm_0074 1 None None None 148643602 Common ispD 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Msm_1542 190 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 148643262 Common - branched-chain-amino-acid aminotransferase, IlvE Msm_1202 217 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 148643135 Nonpathogen - putative monovalent cation/H+ antiporter subunit F Msm_1075 2 None None None 148643097 Common - proteasome, beta subunit Msm_1037 49 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 148643523 Common - formate dehydrogenase, alpha subunit, FdhA Msm_1463 85 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 148643274 Common - threonyl-tRNA synthetase Msm_1214 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 148643360 Common - 3-isopropylmalate dehydratase, large subunit, LeuC Msm_1300 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 148642957 Common rps10p 30S ribosomal protein S10P Msm_0897 238 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 148643403 Common - molybdenum cofactor biosynthesis protein, MoeA Msm_1343 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 148643232 Common leuS leucyl-tRNA synthetase Msm_1172 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 148642269 Common - ferredoxin Msm_0209 63 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 148642190 Common - molybdenum cofactor biosynthesis protein, MoaE Msm_0130 84 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 148643696 Common - ProFAR isomerase-related protein Msm_1636 62 COG1411 COG1411, Uncharacterized protein related to proFAR isomerase (HisA) General function prediction only 148642896 Common - glycosyltransferase, GT1 family Msm_0836 230 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 148642842 Nonpathogen - hypothetical protein Msm_0782 1 None None None 148642409 Nonpathogen - hypothetical protein Msm_0349 1 None None None 148643760 Common - predicted ferredoxin Msm_1700 41 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 148643799 Nonpathogen - hypothetical protein Msm_1739 7 None None None 148643314 Common - cobyrinic acid a,c-diamide synthase Msm_1254 55 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 148642721 Nonpathogen - 30S ribosomal protein S3Ae Msm_0661 34 COG1890 RPS1A, Ribosomal protein S3AE Translation, ribosomal structure and biogenesis 148643778 Common - predicted biopolymer transport protein Msm_1718 16 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 148643381 Common - predicted glycosyltransferase, GT2 family Msm_1321 134 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 148643588 Common - predicted transcriptional regulator, HTH XRE-like family Msm_1528 8 COG1396 HipB, Predicted transcriptional regulators Transcription 148643790 Nonpathogen - hypothetical protein Msm_1730 10 None None None 148643126 Common - energy-converting hydrogenase B, subunit K, EhbK Msm_1066 125 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 148642647 Nonpathogen - hypothetical protein Msm_0587 1 None None None 148642148 Common - hypothetical protein Msm_0088 34 COG2122 COG2122, Uncharacterized conserved protein Function unknown 148643824 Nonpathogen - hypothetical protein Msm_1764 1 None None None 148643286 Common - ornithine carbamoyltransferase, ArgF Msm_1226 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 148642700 Nonpathogen - cell division protein (RNA-binding), PelA Msm_0640 34 COG1537 PelA, Predicted RNA-binding proteins General function prediction only 148642699 Nonpathogen - putative cell wall biosynthesis protein Msm_0639 4 None None None 148642623 Common - fumarate hydratase Msm_0563 145 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 148642327 Common - NAD(P)H-dependent FMN reductase (multimeric flavodoxin) Msm_0267 46 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 148643354 Common - glycosyltransferase, GT2 family Msm_1294 103 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 148643587 Common - predicted ATPase, AAA+ superfamily Msm_1527 35 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 148642238 Nonpathogen - hypothetical protein Msm_0178 4 None None None 148643295 Common - predicted flavoprotein Msm_1235 141 COG2081 COG2081, Predicted flavoproteins General function prediction only 148642183 Nonpathogen - hypothetical protein Msm_0123 8 COG1630 COG1630, Uncharacterized protein conserved in archaea Function unknown 148642830 Common - cobalt ABC transporter, ATPase component, CbiO Msm_0770 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 148642875 Nonpathogen - hypothetical protein Msm_0815 9 COG4069 COG4069, Uncharacterized protein conserved in archaea Function unknown 148642064 Common - predicted lysine decarboxylase Msm_0004 106 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 148642605 Common - hypothetical protein Msm_0545 4 None None None 148643438 Common - putative monooxygenase, ABM family Msm_1378 18 COG1359 COG1359, Uncharacterized conserved protein Function unknown 148643053 Nonpathogen - putative ATPase, glucocorticoid receptor-like (DNA-binding domain) family Msm_0993 4 None None None 148643427 Common - peptidyl-prolyl cis-trans isomerase, PpiB Msm_1367 201 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 148642565 Nonpathogen - hypothetical protein Msm_0505 1 None None None 148643645 Common - adhesin-like protein Msm_1585 30 None None None 148643740 Nonpathogen - hypothetical protein Msm_1680 1 None None None 148643112 Common - prephenate dehydratase, PheA Msm_1052 214 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 148642953 Common - acetyltransferase Msm_0893 105 COG0456 RimI, Acetyltransferases General function prediction only 148642678 Common - pH regulator (monovalent cation:H+ antiporter) Msm_0618 129 COG3263 COG3263, NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain Inorganic ion transport and metabolism 148642738 Nonpathogen - hypothetical protein Msm_0678 3 COG4640 COG4640, Predicted membrane protein Function unknown 148642671 Common radB DNA repair and recombination protein RadB Msm_0611 190 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 148642870 Common - activator of (R)-2-hydroxyglutaryl-CoA dehydratase Msm_0810 63 COG1924 COG1924, Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) Lipid metabolism 148643711 Nonpathogen - hypothetical protein Msm_1651 1 None None None 148642591 Common - adenine/cytosine DNA methyltransferase Msm_0531 9 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 148642247 Common - rubredoxin Msm_0187 60 COG1773 COG1773, Rubredoxin Energy production and conversion 148642334 Common - SAM-dependent methyltransferase (cyclopropane fatty acid synthase-related) Msm_0274 10 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 148642663 Nonpathogen - predicted Zn-ribbon RNA-binding protein involved in translation Msm_0603 18 COG2888 COG2888, Predicted Zn-ribbon RNA-binding protein with a function in translation Translation, ribosomal structure and biogenesis 148642429 Common - glutamate synthase, subunit 3 Msm_0369 58 COG0070 GltB, Glutamate synthase domain 3 Amino acid transport and metabolism 148643164 Common - acetyltransferase, GNAT family Msm_1104 14 COG0456 RimI, Acetyltransferases General function prediction only 148643370 Common - glycosyltransferase, GT2 family Msm_1310 213 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 148643738 Nonpathogen - hypothetical protein Msm_1678 1 None None None 148642600 Common - predicted transcriptional regulator Msm_0540 67 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 148642295 Nonpathogen - hypothetical protein Msm_0235 1 None None None 148642514 Nonpathogen - hypothetical protein Msm_0454 1 None None None 148643787 Common - multimeric flavodoxin Msm_1727 49 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 148643672 Common - predicted UDP-glucose 6-dehydrogenase Msm_1612 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 148643639 Common - excinuclease ABC subunit B Msm_1579 229 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 148642747 Common - deoxycytidine-triphosphate deaminase, Dcd Msm_0687 31 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 148642837 Nonpathogen - hypothetical protein Msm_0777 2 None None None 148642904 Nonpathogen - histone, HmtA Msm_0844 20 COG2036 HHT1, Histones H3 and H4 Chromatin structure and dynamics 148642273 Nonpathogen - histone, HMtA Msm_0213 25 COG2036 HHT1, Histones H3 and H4 Chromatin structure and dynamics 148643405 Nonpathogen - hypothetical protein Msm_1345 1 None None None 148643119 Nonpathogen - predicted RecB family exonuclease Msm_1059 2 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 148643302 Common - tryptophan synthase subunit beta Msm_1242 224 COG1350 COG1350, Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) General function prediction only 148642370 Common - polyferredoxin, iron-sulfur binding Msm_0310 130 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 148642964 Nonpathogen - methyl-coenzyme M reductase, D subunit, McrD Msm_0904 14 COG4055 McrD, Methyl coenzyme M reductase, subunit D Coenzyme metabolism 148642309 Nonpathogen - hypothetical protein Msm_0249 2 COG4640 COG4640, Predicted membrane protein Function unknown 148642287 Common - hydroxymethylglutaryl-CoA (HMG-CoA) reductase, HmgA Msm_0227 69 COG1257 HMG1, Hydroxymethylglutaryl-CoA reductase Lipid metabolism 148643613 Nonpathogen - hypothetical protein Msm_1553 1 None None None 148642161 Common - precorrin-3 methylase, CbiF Msm_0101 203 COG2875 CobM, Precorrin-4 methylase Coenzyme metabolism 148642368 Common - tetrahydromethanopterin formyltransferase Msm_0308 24 COG2037 Ftr, Formylmethanofuran:tetrahydromethanopterin formyltransferase Energy production and conversion 148642827 Common - selenocysteine synthase, SelA Msm_0767 17 COG1921 SelA, Selenocysteine synthase [seryl-tRNASer selenium transferase] Amino acid transport and metabolism 148642081 Common - short chain dehydrogenase (7-alpha-hydroxysteroid dehydrogenase) Msm_0021 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 148643683 Common - glycosyltransferase/dolichyl-phosphate mannose synthase, GT2 family Msm_1623 180 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 148643144 Common - argininosuccinate synthase Msm_1084 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 148642304 Nonpathogen - predicted exosome subunit Msm_0244 34 COG1500 COG1500, Predicted exosome subunit Translation, ribosomal structure and biogenesis 148643195 Nonpathogen rpl44e 50S ribosomal protein L44e Msm_1135 34 COG1631 RPL42A, Ribosomal protein L44E Translation, ribosomal structure and biogenesis 148642229 Nonpathogen - predicted CRISPR-associated protein Msm_0169 7 None None None 148642979 Common - triosephosphate isomerase Msm_0919 37 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 148643747 Nonpathogen - hypothetical protein Msm_1687 2 None None None 148643423 Nonpathogen - preprotein translocase subunit SecG Msm_1363 4 COG4023 SBH1, Preprotein translocase subunit Sec61beta Intracellular trafficking and secretion 148643729 Nonpathogen - hypothetical protein Msm_1669 1 None None None 148643180 Common - methionine aminopeptidase Msm_1120 184 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 148642793 Nonpathogen - 50S ribosomal protein L14e Msm_0733 18 COG2163 RPL14A, Ribosomal protein L14E/L6E/L27E Translation, ribosomal structure and biogenesis 148643621 Common - hypothetical protein Msm_1561 90 COG3425 PksG, 3-hydroxy-3-methylglutaryl CoA synthase Lipid metabolism 148643467 Common - molybdopterin-guanine dinucleotide biosynthesis protein B, MobB Msm_1407 106 COG1763 MobB, Molybdopterin-guanine dinucleotide biosynthesis protein Coenzyme metabolism 148642373 Common - [NiFe]-hydrogenase-3-type complex, small subunit/NADH:quinone oxidoreductase (complex I), subunit PSST/NdhK/NuoB Msm_0313 192 COG3260 COG3260, Ni,Fe-hydrogenase III small subunit Energy production and conversion 148643698 Nonpathogen - hypothetical protein Msm_1638 3 None None None 148642924 Common - predicted transcriptional regulator Msm_0864 74 COG1733 COG1733, Predicted transcriptional regulators Transcription 148642433 Common - isocitrate/isopropylmalate dehydrogenase, LeuB Msm_0373 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 148643508 Common - SAM-dependent methyltransferase Msm_1448 67 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 148643663 Common - hypothetical protein Msm_1603 16 COG1872 COG1872, Uncharacterized conserved protein Function unknown 148643024 Common - calcineurin-like phosphoesterase Msm_0964 75 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 148643079 Nonpathogen - methyl-coenzyme M reductase, beta subunit, McrB Msm_1019 14 COG4054 McrB, Methyl coenzyme M reductase, beta subunit Coenzyme metabolism 148643117 Common - hypothetical protein Msm_1057 16 COG2029 COG2029, Uncharacterized conserved protein Function unknown 148642159 Nonpathogen - hypothetical protein Msm_0099 3 None None None 148642263 Common - nucleoside diphosphate kinase, Ndk Msm_0203 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 148642174 Nonpathogen - hypothetical protein Msm_0114 2 None None None 148642898 Nonpathogen - putative thioredoxin/glutaredoxin Msm_0838 8 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 148643570 Common - putative SAM-dependent methyltransferase Msm_1510 3 None None None 148642853 Nonpathogen - hypothetical protein Msm_0793 6 COG4010 COG4010, Uncharacterized protein conserved in archaea Function unknown 148642602 Common - methylenetetrahydromethanopterin reductase Msm_0542 54 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 148643666 Common - arylsulfatase regulator, AslB Msm_1606 96 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 148642270 Nonpathogen - hypothetical protein Msm_0210 1 None None None 148643005 Common - hydrogenase expression/formation protein, HypD Msm_0945 109 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 148642707 Nonpathogen - predicted RNA-binding protein, contains TRAM domain Msm_0647 2 COG4085 COG4085, Predicted RNA-binding protein, contains TRAM domain General function prediction only 148643326 Common - cobalamin biosynthesis protein D, CobD Msm_1266 146 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 148642546 Common - chlorohydrolase Msm_0486 56 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 148642095 Nonpathogen - hypothetical protein Msm_0035 1 None None None 148642316 Nonpathogen - putative transposase Msm_0256 4 None None None 148643723 Nonpathogen - hypothetical protein Msm_1663 1 None None None 148643767 Common - nitrogenase reductase-like protein Msm_1707 71 COG1348 NifH, Nitrogenase subunit NifH (ATPase) Inorganic ion transport and metabolism 148642398 Nonpathogen - hypothetical protein Msm_0338 1 None None None 148643173 Common - adhesin-like protein Msm_1113 23 None None None 148642441 Nonpathogen - hypothetical protein Msm_0381 4 None None None 148643271 Common - putative phosphoserine phosphatase Msm_1211 49 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 148642488 Common - integrase-recombinase protein, phage integrase family Msm_0428 230 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 148642493 Common - V-type ATP synthase subunit D Msm_0433 45 COG1394 NtpD, Archaeal/vacuolar-type H+-ATPase subunit D Energy production and conversion 148643832 Nonpathogen - hypothetical protein Msm_1772 10 COG1645 COG1645, Uncharacterized Zn-finger containing protein General function prediction only 148643849 Common - predicted ATPase, AAA+ superfamily Msm_1789 33 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 148642291 Common - 3-dehydroquinate dehydratase Msm_0231 57 COG0710 AroD, 3-dehydroquinate dehydratase Amino acid transport and metabolism 148642772 Common - hypothetical protein Msm_0712 27 None None None 148642114 Common - 2'-5' RNA ligase, LigT Msm_0054 92 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 148642665 Nonpathogen - peptidyl-tRNA hydrolase Msm_0605 34 COG1990 COG1990, Uncharacterized conserved protein Function unknown 148643701 Nonpathogen - hypothetical protein Msm_1641 1 None None None 148642391 Common - 2-oxoisovalerate ferredoxin oxidoreductase, delta subunit Msm_0331 26 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 148642615 Common - MoxR-like ATPase Msm_0555 177 COG0714 COG0714, MoxR-like ATPases General function prediction only 148642177 Nonpathogen - hypothetical protein Msm_0117 4 None None None 148642526 Common - predicted tRNA-binding protein Msm_0466 15 COG2517 COG2517, Predicted RNA-binding protein containing a C-terminal EMAP domain General function prediction only 148643352 Common - transcriptional accessory protein, S1 RNA binding family, Tex Msm_1292 185 COG2183 Tex, Transcriptional accessory protein Transcription 148642644 Nonpathogen - cobalt ABC transporter, permease component Msm_0584 6 None None None 148643220 Nonpathogen - nitrogenase molybdenum-iron protein, NifD Msm_1160 31 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 148642200 Nonpathogen - hypothetical protein Msm_0140 30 COG1701 COG1701, Uncharacterized protein conserved in archaea Function unknown 148643755 Common - excinuclease ABC, subunit C, UvrC Msm_1695 224 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 148643359 Common - 3-isopropylmalate dehydratase, small subunit, LeuD Msm_1299 211 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 148643242 Common hisI phosphoribosyl-AMP cyclohydrolase Msm_1182 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 148643579 Nonpathogen - IS element (transposase remnant) Msm_1519 1 None None None 148642477 Nonpathogen - predicted transmembrane protein with a zinc ribbon Msm_0417 4 COG4068 COG4068, Uncharacterized protein containing a Zn-ribbon Function unknown 148642510 Common - hypothetical protein Msm_0450 21 None None None 148642696 Common - hydrogenase expression/formation protein, HypC Msm_0636 41 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 148643503 Common - bifunctional short chain isoprenyl diphosphate synthase, IdsA Msm_1443 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 148642193 Common - predicted thioesterase, FcbC Msm_0133 38 COG0824 FcbC, Predicted thioesterase General function prediction only 148643456 Common - tungsten formylmethanofuran dehydrogenase, subunit E, FwdE Msm_1396 37 COG2191 COG2191, Formylmethanofuran dehydrogenase subunit E Energy production and conversion 148643266 Common - imidazoleglycerol-phosphate dehydrogenase, HisB Msm_1206 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 148643206 Common - anthranilate/para-aminobenzoate synthase component I, TrpE Msm_1146 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 148642322 Common - desulfoferrodoxin (dfx) Msm_0262 26 COG2033 COG2033, Desulfoferrodoxin Energy production and conversion 148643343 Common - thiamine monphosphate kinase, ThiL Msm_1283 210 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 148643365 Common - adhesin-like protein Msm_1305 56 None None None 148642275 Nonpathogen - conserved hypothetical integral membrane protein Msm_0215 Msm_0215 9 COG1300 SpoIIM, Uncharacterized membrane protein Function unknown 148642536 Nonpathogen - hypothetical protein Msm_0476 1 None None None 148642104 Common - PLP dependent aminotransferase (aspartate) Msm_0044 192 COG1168 MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities Amino acid transport and metabolism 148643163 Common - phosphoribosyl-ATP pyrophosphohydrolase, HisE Msm_1103 120 COG0140 HisI, Phosphoribosyl-ATP pyrophosphohydrolase Amino acid transport and metabolism 148642809 Nonpathogen - 30S ribosomal protein S4e Msm_0749 34 COG1471 RPS4A, Ribosomal protein S4E Translation, ribosomal structure and biogenesis 148643581 Nonpathogen - hypothetical protein Msm_1521 2 None None None 148643278 Common - predicted acid phosphatase (survival protein), SurE Msm_1218 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 148643066 Nonpathogen - hypothetical protein Msm_1006 14 COG4065 COG4065, Uncharacterized protein conserved in archaea Function unknown 148643227 Common - cobalt-precorrin-6Y C(5)-methyltransferase Msm_1167 107 COG2241 CobL, Precorrin-6B methylase 1 Coenzyme metabolism 148642385 Nonpathogen - hypothetical protein Msm_0325 8 COG4041 COG4041, Predicted membrane protein Function unknown 148642209 Common - predicted acetylesterase Msm_0149 42 COG0627 COG0627, Predicted esterase General function prediction only 148643733 Nonpathogen - hypothetical protein Msm_1673 1 None None None 148643842 Nonpathogen - hypothetical protein Msm_1782 1 None None None 148642717 Common - cofactor-independent phosphoglycerate mutase Msm_0657 53 COG3635 COG3635, Predicted phosphoglycerate mutase, AP superfamily Carbohydrate transport and metabolism 148642710 Common - transcriptional regulator, TetR/AcrR family Msm_0650 69 COG1309 AcrR, Transcriptional regulator Transcription 148642584 Common - DNA mismatch repair ATPase, MutS Msm_0524 86 COG1193 COG1193, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 148643526 Nonpathogen - hypothetical protein Msm_1466 1 None None None 148642252 Common - argininosuccinate lyase Msm_0192 234 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 148643103 Common - dihydroorotate dehydrogenase electron transfer subunit Msm_1043 138 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 148642202 Common - predicted ATPase (PP-loop superfamily) Msm_0142 48 COG2102 COG2102, Predicted ATPases of PP-loop superfamily General function prediction only 148642802 Nonpathogen rpl18p 50S ribosomal protein L18P Msm_0742 35 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 148642071 Nonpathogen - hypothetical protein Msm_0011 1 None None None 148643329 Nonpathogen - putative Met repressor-like protein Msm_1269 1 None None None 148643084 Common - pheromone shutdown protein, TraB family Msm_1024 39 COG1916 COG1916, Uncharacterized homolog of PrgY (pheromone shutdown protein) Function unknown 148642577 Common - methyltransferase activation protein, MapA Msm_0517 36 COG3894 COG3894, Uncharacterized metal-binding protein General function prediction only 148643655 Common - SAM-dependent methyltransferase, FkbM family Msm_1595 50 COG2263 COG2263, Predicted RNA methylase Translation, ribosomal structure and biogenesis 148642259 Nonpathogen - hypothetical protein Msm_0199 19 COG1412 COG1412, Uncharacterized proteins of PilT N-term./Vapc superfamily General function prediction only 148643492 Nonpathogen - DNA-directed RNA polymerase subunit N Msm_1432 34 COG1644 RPB10, DNA-directed RNA polymerase, subunit N (RpoN/RPB10) Transcription 148643433 Common - methyltransferase, HemK Msm_1373 178 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 148642736 Common - hypothetical protein Msm_0676 15 COG2364 COG2364, Predicted membrane protein Function unknown 148643401 Common ileS isoleucyl-tRNA synthetase Msm_1341 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 148642761 Common - signal recognition particle GTPase SRP54 Msm_0701 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 148642355 Common - formate dehydrogenase accessory protein, FdhD Msm_0295 119 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 148643291 Common argS arginyl-tRNA synthetase Msm_1231 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 148642417 Nonpathogen - hypothetical protein Msm_0357 4 None None None 148642126 Common - N-acetylglucosamine-1-phosphate transferase, GT4 family Msm_0066 211 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 148642790 Nonpathogen - putative transposase Msm_0730 4 None None None 148642431 Common - predicted glutamine amidotransferase involved in pyridoxine biosynthesis, Pdx2 Msm_0371 87 COG0311 PDX2, Predicted glutamine amidotransferase involved in pyridoxine biosynthesis Coenzyme metabolism 148642719 Common - hypothetical protein Msm_0659 46 COG1836 COG1836, Predicted membrane protein Function unknown 148642972 Nonpathogen rpoH DNA-directed RNA polymerase subunit H Msm_0912 17 COG2012 RPB5, DNA-directed RNA polymerase, subunit H, RpoH/RPB5 Transcription 148643565 Nonpathogen - hypothetical protein Msm_1505 1 None None None 148642220 Common - asparagine synthetase, AsnB Msm_0160 180 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 148643308 Common - multidrug ABC transporter, permease component Msm_1248 195 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 148643391 Common - sugar transferase, WcaJ Msm_1331 183 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 148643494 Nonpathogen - hypothetical protein Msm_1434 1 None None None 148642712 Common - pyruvate formate-lyase activating enzyme, PflA Msm_0652 117 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 148643247 Common - ERCC4-like helicase Msm_1187 51 COG1111 MPH1, ERCC4-like helicases DNA replication, recombination, and repair 148642818 Common rps19p 30S ribosomal protein S19P Msm_0758 227 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 148642143 Common - heterodisulfide reductase, subunit B, HdrB Msm_0083 50 COG2048 HdrB, Heterodisulfide reductase, subunit B Energy production and conversion 148642132 Nonpathogen - putative exonuclease SBCC Msm_0072 1 None None None 148643288 Common - Na+-driven multidrug efflux pump Msm_1228 153 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 148642784 Nonpathogen - 4-hydroxybenzoate synthetase (chorismate lyase) Msm_0724 12 COG3161 UbiC, 4-hydroxybenzoate synthetase (chorismate lyase) Coenzyme metabolism 148643137 Nonpathogen - putative permease (transport) Msm_1077 1 None None None 148642121 Common - predicted ATPase (AAA+ superfamily) Msm_0061 46 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 148643300 Nonpathogen - predicted AAA ATPase Msm_1240 5 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 148643539 Common - exodeoxyribonuclease, XthA Msm_1479 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 148643230 Common - arsenite-transporting ATPase Msm_1170 99 COG0003 ArsA, Predicted ATPase involved in chromosome partitioning Cell division and chromosome partitioning 148643093 Common - hypothetical protein Msm_1033 66 COG1469 COG1469, Uncharacterized conserved protein Function unknown 148643479 Nonpathogen - putative transposase Msm_1419 4 None None None 148642574 Nonpathogen - hypothetical protein Msm_0514 2 None None None 148643691 Nonpathogen - predicted DNA-directed RNA polymerase II, subunit RPC10 Msm_1631 2 COG1571 COG1571, Predicted DNA-binding protein containing a Zn-ribbon domain General function prediction only 148643124 Common - energy-converting hydrogenase B, subunit M, EhbM Msm_1064 192 COG3260 COG3260, Ni,Fe-hydrogenase III small subunit Energy production and conversion 148642087 Common - glutamate synthase, domain 2 with rubredoxin Msm_0027 202 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 148642869 Nonpathogen - hypothetical protein Msm_0809 14 COG4051 COG4051, Uncharacterized protein conserved in archaea Function unknown 148643647 Common - adhesin-like protein Msm_1587 30 None None None 148643393 Common radA DNA repair and recombination protein RadA Msm_1333 229 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 148642402 Nonpathogen - putative transposase Msm_0342 4 None None None 148642949 Nonpathogen - hypothetical protein Msm_0889 1 None None None 148642864 Common - translation initiation factor aIF-2B, alpha subunit Msm_0804 132 COG0182 COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 148643826 Common - O-linked GlcNAc transferase Msm_1766 88 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 148642766 Nonpathogen - ribosomal protein L39a Msm_0706 29 COG2167 RPL39, Ribosomal protein L39E Translation, ribosomal structure and biogenesis 148642743 Nonpathogen - hypothetical protein Msm_0683 8 COG3874 COG3874, Uncharacterized conserved protein Function unknown 148642587 Nonpathogen - IS element (transposase remnant) Msm_0527 4 None None None 148642945 Common - adhesin-like protein Msm_0885 42 None None None 148642596 Nonpathogen - hypothetical protein Msm_0536 1 None None None 148642745 Nonpathogen - hypothetical protein Msm_0685 1 None None None 148642347 Common - prolyl-tRNA synthetase Msm_0287 248 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 148643008 Nonpathogen - hypothetical protein Msm_0948 1 None None None 148642217 Common - predicted type I restriction-modification enzyme, subunit S Msm_0157 16 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 148643046 Common - conjugated bile salt acid hydrolase (CBAH) Msm_0986 34 COG3049 COG3049, Penicillin V acylase and related amidases Cell envelope biogenesis, outer membrane 148643511 Common - predicted O-linked GlcNAc transferase Msm_1451 23 COG3071 HemY, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 148642659 Nonpathogen - hypothetical protein Msm_0599 28 COG1784 COG1784, Predicted membrane protein Function unknown 148643815 Common - purine/pyrimidine phosphoribosyl transferase Msm_1755 3 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 148642245 Nonpathogen - hypothetical protein Msm_0185 1 None None None 148643408 Common - rubrerythrin Msm_1348 20 COG1592 COG1592, Rubrerythrin Energy production and conversion 148643528 Common - adenylosuccinate synthetase Msm_1468 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 148642673 Common - phosphatidylglycerophosphate synthase, PgsA Msm_0613 74 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 148642650 Nonpathogen - hypothetical protein Msm_0590 1 None None None 148643264 Nonpathogen - F420-dependent methylenetetrahydromethanopterin dehydrogenase Msm_1204 15 COG1927 Mtd, Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase Energy production and conversion 148642062 Common - integrase-recombinase protein Msm_0002 72 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 148643637 Common - ribose-phosphate pyrophosphokinase Msm_1577 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 148642422 Common - coenzyme F420-reducing hydrogenase (Ni,Fe-hydrogenase maturation protease), delta subunit Msm_0362 42 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 148643800 Common - O-linked GlcNAc transferase Msm_1740 101 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 148643027 Common hemA glutamyl-tRNA reductase Msm_0967 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 148643640 Common - hypothetical protein Msm_1580 3 None None None 148642751 Common - mutator mutT protein (NUDIX domain) Msm_0691 172 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 148643718 Nonpathogen - hypothetical protein Msm_1658 1 None None None 148643537 Common - ATP:dephospho-CoA triphosphoribosyl transferase Msm_1477 33 COG1767 CitG, Triphosphoribosyl-dephospho-CoA synthetase Coenzyme metabolism 148643213 Common - cation transport ATPase, HAD family Msm_1153 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 148642607 Nonpathogen - predicted nucleotidyltransferase, cytidyltransferase-related Msm_0547 5 COG1323 COG1323, Predicted nucleotidyltransferase General function prediction only 148642563 Common - flavodoxin, FldA Msm_0503 27 COG0716 FldA, Flavodoxins Energy production and conversion 148642080 Common - predicted O-linked GlnNAc transferase Msm_0020 4 None None None 148643377 Common - glycosyltransferase (glycogen phosphorylase), GT1 family Msm_1317 22 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 148643758 Common - methyl coenzyme M reductase system, component A2-like protein Msm_1698 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 148643677 Common - orotidine-5'-phosphate decarboxylase, PyrF Msm_1617 149 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 148643383 Common - glycosyltransferase, GT2 family Msm_1323 158 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 148643197 Nonpathogen - DNA polymerase sliding clamp subunit, PCNA family, Pcn Msm_1137 34 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 148643851 Nonpathogen - hypothetical protein Msm_1791 6 None None None 148642808 Common rpl5p 50S ribosomal protein L5P Msm_0748 238 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 148643839 Nonpathogen - hypothetical protein Msm_1779 4 None None None 148643225 Common - predicted phosphohydrolase (metal-dependent) Msm_1165 86 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 148642551 Common - nicotinate-nucleotide pyrophosphorylase (carboxylating), NadC Msm_0491 207 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 148642557 Common - hypothetical protein Msm_0497 38 COG1637 COG1637, Predicted nuclease of the RecB family DNA replication, recombination, and repair 148642285 Common - hypothetical protein Msm_0225 31 COG1852 COG1852, Uncharacterized conserved protein Function unknown 148643298 Common hisD histidinol dehydrogenase Msm_1238 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 148642512 Nonpathogen - predicted DNA-binding protein (regulator) Msm_0452 33 COG1571 COG1571, Predicted DNA-binding protein containing a Zn-ribbon domain General function prediction only 148643425 Common - 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase Msm_1365 25 COG0122 AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 148642959 Common - elongation factor EF-2 Msm_0899 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 148643312 Common - cation transporting P-type ATPase, HAD family Msm_1252 163 COG4087 COG4087, Soluble P-type ATPase General function prediction only 148643096 Nonpathogen - predicted methyltransferase Msm_1036 35 COG2520 COG2520, Predicted methyltransferase General function prediction only 148642844 Nonpathogen - ferredoxin Msm_0784 6 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 148642637 Nonpathogen - predicted dinucleotide-utilizing enzyme, ThiF/HesA family Msm_0577 7 COG4015 COG4015, Predicted dinucleotide-utilizing enzyme of the ThiF/HesA family General function prediction only 148642831 Common - cobalt ABC transporter, permease component, CbiQ Msm_0771 60 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 148643797 Nonpathogen - putative transcription regulator Msm_1737 2 COG4742 COG4742, Predicted transcriptional regulator Transcription 148643054 Common - predicted nucleotidyltransferase Msm_0994 25 COG1323 COG1323, Predicted nucleotidyltransferase General function prediction only 148643596 Common - pleiotropic regulatory protein DegT (PLP-dependent) Msm_1536 192 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 148642980 Nonpathogen - hypothetical protein Msm_0920 1 None None None 148643260 Common - hypothetical protein Msm_1200 40 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 148642236 Common - ribonuclease III (dsRNA-specific), Rnc Msm_0176 216 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 148643462 Nonpathogen - hypothetical protein Msm_1402 6 COG4744 COG4744, Uncharacterized conserved protein Function unknown 148643110 Nonpathogen - hypothetical protein Msm_1050 3 None None None 148642503 Nonpathogen - hypothetical protein Msm_0443 1 None None None 148642332 Common - endonuclease III Msm_0272 241 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 148643284 Common - acetolactate synthase, small subunit (regulatory), IlvH Msm_1224 193 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 148642625 Common - phosphate ABC transporter, ATPase component, PstB Msm_0565 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 148642325 Common - O-acetylhomoserine sulfhydrylase Msm_0265 206 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 148642181 Common - DNA repair exonuclease (SbcD/Mre11-family), Rad32 Msm_0121 71 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 148643239 Common - shikimate 5-dehydrogenase, AroE Msm_1179 225 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 148643334 Nonpathogen - predicted potassium ion transport protein Msm_1274 18 COG3273 COG3273, Uncharacterized conserved protein Function unknown 148642439 Common argJ bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein Msm_0379 167 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 148642834 Common - multidrug ABC transporter, ATPase component Msm_0774 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 148643409 Common - F420H2-oxidase/flavoprotein, FprA Msm_1349 78 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 148643344 Common - pyruvate formate-lyase activating enzyme, PflA Msm_1284 87 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 148643461 Nonpathogen - biopolymer transport protein Msm_1401 6 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 148642692 Common - predicted hydrolase, HD superfamily Msm_0632 32 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 148643731 Nonpathogen - large terminase subunit Msm_1671 2 COG5362 COG5362, Phage-related terminase General function prediction only 148642320 Nonpathogen - archaea-specific RecJ-like exonuclease Msm_0260 21 COG1107 COG1107, Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain DNA replication, recombination, and repair 148642756 Nonpathogen - Fe-S oxidoreductase Msm_0696 11 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 148643363 Common - UDP-N-acetyl-D-mannosaminuronate dehydrogenase Msm_1303 206 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 148642208 Common - predicted oxidoreductase, aldo/keto reductase family Msm_0148 85 COG1453 COG1453, Predicted oxidoreductases of the aldo/keto reductase family General function prediction only 148643372 Common - glycosyltransferase, GT2 family Msm_1312 125 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 148643175 Nonpathogen - putative transposase Msm_1115 3 None None None 148643450 Common - transcriptional regulator, LysR family Msm_1390 12 COG0583 LysR, Transcriptional regulator Transcription 148643653 Common - polysaccharide/polyol phosphate ABC transporter, permease component Msm_1593 152 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 148642642 Common - peptide methionine sulfoxide reductase, PMSR Msm_0582 206 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 148642253 Nonpathogen - ribosomal protein S27ae Msm_0193 22 COG1998 RPS31, Ribosomal protein S27AE Translation, ribosomal structure and biogenesis 148642078 Nonpathogen - hypothetical protein Msm_0018 1 None None None 148642935 Common - lysine-oxoglutarate reductase/Saccharopine dehydrogenase (LOR/SDH) bifunctional enzyme Msm_0875 33 COG1915 COG1915, Uncharacterized conserved protein Function unknown 148643595 Common - predicted dTDP-D-glucose 4,6-dehydratase Msm_1535 164 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 148642297 Common - 3-polyprenyl-4-hydroxybenzoate decarboxylase, UbiX Msm_0237 152 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 148642185 Nonpathogen rpl40e 50S ribosomal protein L40e Msm_0125 23 COG1552 RPL40A, Ribosomal protein L40E Translation, ribosomal structure and biogenesis 148643064 Nonpathogen - photosynthetic reaction centre cytoplasmic domain containing protein Msm_1004 3 COG1873 COG1873, Uncharacterized conserved protein Function unknown 148643033 Nonpathogen - GTP cyclohydrolase III Msm_0973 15 COG2429 COG2429, Uncharacterized conserved protein Function unknown 148642617 Common - pyruvate:ferredoxin oxidoreductase, gamma subunit, PorG Msm_0557 73 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 148642630 Nonpathogen - hypothetical protein Msm_0570 3 None None None 148642987 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit alpha Msm_0927 112 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 148642581 Common - hypothetical protein Msm_0521 7 COG4713 COG4713, Predicted membrane protein Function unknown 148643681 Common - cobalt ABC transporter, ATPase component, CbiO Msm_1621 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 148642559 Nonpathogen - hypothetical protein Msm_0499 1 COG1594 RPB9, DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS Transcription 148643067 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit H Msm_1007 17 COG1962 MtrH, Tetrahydromethanopterin S-methyltransferase, subunit H Coenzyme metabolism 148643200 Nonpathogen - hypothetical protein Msm_1140 1 None None None 148642195 Nonpathogen - coenzyme F420-reducing hydrogenase, beta subunit Msm_0135 23 COG1035 FrhB, Coenzyme F420-reducing hydrogenase, beta subunit Energy production and conversion 148643576 Common - histidinol-phosphate aminotransferase, HisC Msm_1516 222 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 148642639 Common - polyferredoxin, iron-sulfur binding Msm_0579 61 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 148643648 Common - transposase Msm_1588 24 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 148642990 Common - peptidyl-prolyl cis-trans isomerase, FKBP-type Msm_0930 136 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 148642277 Nonpathogen - tRNA-splicing endonuclease subunit alpha Msm_0217 33 COG1676 SEN2, tRNA splicing endonuclease Translation, ribosomal structure and biogenesis 148642474 Common - Na+-driven multidrug efflux pump, NorM Msm_0414 108 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 148642715 Common - glucose-1-phosphate thymidylyltransferase Msm_0655 242 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 148642922 Common - aspartate carbamoyltransferase regulatory subunit Msm_0862 64 COG1781 PyrI, Aspartate carbamoyltransferase, regulatory subunit Nucleotide transport and metabolism 148643676 Nonpathogen - hypothetical protein Msm_1616 4 None None None 148642187 Nonpathogen - hypothetical protein Msm_0127 1 None None None 148643759 Nonpathogen - predicted universal stress protein, UspA Msm_1699 19 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 148643017 Common - adhesin-like protein Msm_0957 5 None None None 148643750 Nonpathogen - hypothetical protein Msm_1690 1 None None None 148643454 Common - iron(III) ABC transporter, permease component Msm_1394 191 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 148642153 Common - conserved hypothetical membrane-spanning protein Msm_0093 Msm_0093 34 COG1511 COG1511, Predicted membrane protein Function unknown 148643444 Nonpathogen - DNA polymerase II large subunit Msm_1384 25 COG1933 COG1933, Archaeal DNA polymerase II, large subunit DNA replication, recombination, and repair 148643028 Common - bifunctional precorrin-2 oxidase/chelatase (siroheme synthase), CysG Msm_0968 91 COG1648 CysG, Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) Coenzyme metabolism 148642442 Nonpathogen - hypothetical protein Msm_0382 7 None None None 148643226 Nonpathogen - hypothetical protein Msm_1166 6 COG1950 COG1950, Predicted membrane protein Function unknown 148642795 Nonpathogen rpl34e 50S ribosomal protein L34e Msm_0735 15 COG2174 RPL34A, Ribosomal protein L34E Translation, ribosomal structure and biogenesis 162330297 Common - tryptophan synthase subunit beta Msm_1142 226 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 148642653 Common - multidrug ABC transporter, ATPase component, CcmA Msm_0593 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 148643048 Common - phosphoenolpyruvate synthase Msm_0988 236 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 148643491 Common rps9p 30S ribosomal protein S9P Msm_1431 245 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 148643105 Common - possible glycosyltransferase Msm_1045 35 None None None 148642310 Nonpathogen - hypothetical protein Msm_0250 1 None None None 148642384 Nonpathogen - hypothetical protein Msm_0324 4 COG4040 COG4040, Predicted membrane protein Function unknown 148642093 Common - ketopantoate reductase, ApbA Msm_0033 88 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 148643051 Common - nitrate/sulfonate/bicarbonate ABC transporter, substrate-binding component Msm_0991 146 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 148642903 Common - 2-deoxyribose-5-phosphate aldolase (DERA), DeoC Msm_0843 134 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 148643717 Nonpathogen - hypothetical protein Msm_1657 1 None None None 148643041 Nonpathogen - hypothetical protein Msm_0981 2 None None None 148643415 Common - ADP-ribose pyrophosphatase, NUDIX hydrolase family Msm_1355 144 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 148643721 Nonpathogen - hypothetical protein Msm_1661 1 COG2411 COG2411, Uncharacterized conserved protein Function unknown 148642119 Nonpathogen - SAM-dependent methyltransferase Msm_0059 4 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 148642235 Common - homoserine O-acetyltransferase, MetX Msm_0175 182 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 148643840 Nonpathogen - hypothetical protein Msm_1780 4 None None None 148643668 Common - predicted oxidoreductase, aldo/keto reductase family Msm_1608 194 COG1453 COG1453, Predicted oxidoreductases of the aldo/keto reductase family General function prediction only 148642086 Common - predicted transcriptional regulator Msm_0026 80 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 148642573 Common - tyrosyl-tRNA synthetase Msm_0513 167 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 148642685 Nonpathogen secE preprotein translocase subunit SecE Msm_0625 1 COG2443 Sss1, Preprotein translocase subunit Sss1 Intracellular trafficking and secretion 148643720 Nonpathogen - hypothetical protein Msm_1660 1 None None None 148642226 Common - predicted helicase Msm_0166 106 COG1203 COG1203, Predicted helicases General function prediction only 148642588 Nonpathogen - IS element (transposase remnant) Msm_0528 1 None None None 148642963 Nonpathogen - methyl-coenzyme M reductase, gamma subunit, McrG Msm_0903 14 COG4057 McrG, Methyl coenzyme M reductase, gamma subunit Coenzyme metabolism 148642495 Common - V-type ATP synthase subunit A Msm_0435 247 COG1155 NtpA, Archaeal/vacuolar-type H+-ATPase subunit A Energy production and conversion 148643847 Common - O-linked GlcNAc transferase Msm_1787 18 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 148643531 Common - acyl-CoA synthetase Msm_1471 176 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 148643498 Common - predicted dioxygenase Msm_1438 65 COG1355 COG1355, Predicted dioxygenase General function prediction only 148642128 Nonpathogen - hypothetical protein Msm_0068 1 None None None 148642900 Nonpathogen - hypothetical protein Msm_0840 7 COG4014 COG4014, Uncharacterized protein conserved in archaea Function unknown 148643506 Common - hydroxylamine reductase Msm_1446 74 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 148642163 Nonpathogen - hypothetical protein Msm_0103 12 COG4033 COG4033, Uncharacterized protein conserved in archaea Function unknown 148642179 Nonpathogen - predicted nuclease Msm_0119 5 None None None 148642535 Nonpathogen - hypothetical protein Msm_0475 1 None None None 148642975 Nonpathogen - hypothetical protein Msm_0915 1 None None None 148642281 Nonpathogen - adhesin-like protein Msm_0221 2 None None None 148643615 Common - SAM-dependent methyltransferase Msm_1555 43 COG4121 COG4121, Uncharacterized conserved protein Function unknown 148642481 Nonpathogen - hypothetical protein Msm_0421 1 None None None 148642454 Common - rRNA methylase, SpoU family Msm_0394 162 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 148642549 Common - carbamoyl phosphate synthase small subunit Msm_0489 234 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 148642929 Common - GTPase, GTP1/OBG family Msm_0869 235 COG1084 COG1084, Predicted GTPase General function prediction only 148642977 Common - thiamine monophosphate synthase, ThiE Msm_0917 204 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 148643477 Nonpathogen - hypothetical protein Msm_1417 16 COG1693 COG1693, Uncharacterized protein conserved in archaea Function unknown 148642260 Common - translation initiation factor IF-2 subunit gamma Msm_0200 249 COG5257 GCD11, Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase) Translation, ribosomal structure and biogenesis 148643480 Common - helicase, UvrD/REP family Msm_1420 229 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 148642066 Nonpathogen - hypothetical protein Msm_0006 1 COG4640 COG4640, Predicted membrane protein Function unknown 148643420 Common - signal recognition particle protein Srp54 Msm_1360 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 148642430 Common - glutamate synthase, subunit 1 Msm_0370 237 COG0067 GltB, Glutamate synthase domain 1 Amino acid transport and metabolism 148642822 Common rpl3p 50S ribosomal protein L3P Msm_0762 151 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 148643489 Nonpathogen - 50S ribosomal protein L18e Msm_1429 34 COG1727 RPL18A, Ribosomal protein L18E Translation, ribosomal structure and biogenesis 148642914 Nonpathogen - hypothetical protein Msm_0854 1 None None None 148643828 Nonpathogen - hypothetical protein Msm_1768 4 None None None 148643610 Common - uroporphyrin-III C-methyltransferase Msm_1550 206 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 148642886 Common - chaperonin, Cpn60/TCP-1/thermosome family, GroL Msm_0826 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 148642396 Nonpathogen - hypothetical protein Msm_0336 1 None None None 148643624 Common - predicted SAM-dependent methyltransferase Msm_1564 52 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 148643650 Common - adhesin-like protein Msm_1590 56 None None None 148643281 Nonpathogen - hypothetical protein Msm_1221 13 COG4020 COG4020, Uncharacterized protein conserved in archaea Function unknown 148642654 Common - multidrug ABC transporter, permease component Msm_0594 9 COG4200 COG4200, Uncharacterized protein conserved in bacteria Function unknown 148643422 Common - molybdenum cofactor biosynthesis protein C, MoaC Msm_1362 196 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 148642467 Common - P-loop containing nucleoside triphosphate hydrolase (NAD(P)-binding) Msm_0407 17 COG3367 COG3367, Uncharacterized conserved protein Function unknown 148643773 Common - predicted regulatory protein, amino acid-binding ACT domain family Msm_1713 38 COG4747 COG4747, ACT domain-containing protein General function prediction only 148643442 Common - hypothetical protein Msm_1382 68 COG1738 COG1738, Uncharacterized conserved protein Function unknown 148642667 Common - putative ATPase RIL Msm_0607 249 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 148642674 Nonpathogen - hypothetical protein Msm_0614 5 COG1849 COG1849, Uncharacterized protein conserved in archaea Function unknown 148642318 Nonpathogen - hypothetical protein Msm_0258 2 COG1439 COG1439, Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module General function prediction only 148643240 Common - predicted metal-dependent membrane protease Msm_1180 48 None None None 148642460 Nonpathogen - hypothetical protein Msm_0400 1 None None None 148642627 Common - phosphate ABC transporter, permease component, PstC Msm_0567 232 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 148643310 Nonpathogen - predicted transcriptional regulator, PadR-like family Msm_1250 7 COG1695 COG1695, Predicted transcriptional regulators Transcription 148643794 Common - predicted thymidylate synthase, ThyA Msm_1734 17 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 148643525 Common - multidrug efflux permease, AraJ Msm_1465 208 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 148642266 Nonpathogen rpl7ae 50S ribosomal protein L7Ae Msm_0206 34 COG1358 RPL8A, Ribosomal protein HS6-type (S12/L30/L7a) Translation, ribosomal structure and biogenesis 148642501 Nonpathogen - vacuolar-type H+-transporting ATP synthase, subunit H Msm_0441 3 None None None 148642695 Nonpathogen - predicted regulator of amino acid metabolism Msm_0635 21 COG2150 COG2150, Predicted regulator of amino acid metabolism, contains ACT domain General function prediction only 148643142 Nonpathogen - hypothetical protein Msm_1082 1 None None None 148642569 Nonpathogen - hypothetical protein Msm_0509 3 None None None 148643358 Common - 3-isopropylmalate dehydrogenase, LeuB Msm_1298 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 148642243 Nonpathogen - RNA-binding protein, PUA domain family Msm_0183 34 COG2016 COG2016, Predicted RNA-binding protein (contains PUA domain) Translation, ribosomal structure and biogenesis 148642846 Common - transglutaminase-like protein, putative cysteine protease Msm_0786 57 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 148642335 Common valS valyl-tRNA synthetase Msm_0275 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 148642547 Nonpathogen - hypothetical protein Msm_0487 1 None None None 148642068 Nonpathogen - putative transposase Msm_0008 4 None None None 148642704 Common - thiamine biosynthesis protein ThiC Msm_0644 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 148642888 Common - possible glycosyltransferase Msm_0828 44 None None None 148642803 Nonpathogen rpl19e 50S ribosomal protein L19e Msm_0743 34 COG2147 RPL19A, Ribosomal protein L19E Translation, ribosomal structure and biogenesis 148643332 Nonpathogen - hypothetical protein Msm_1272 3 None None None 148642537 Nonpathogen - hypothetical protein Msm_0477 1 None None None 148642528 Common - hypothetical protein Msm_0468 31 COG3548 COG3548, Predicted integral membrane protein Function unknown 148643057 Common - dihydroorotase, PyrC Msm_0997 209 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 148642382 Nonpathogen - predicted [NiFe]-hydrogenase-3-type complex Eha, membrane protein EhaE Msm_0322 4 COG4038 COG4038, Predicted membrane protein Function unknown 148642069 Nonpathogen - hypothetical protein Msm_0009 2 None None None 148643761 Common - predicted FAD-dependent dehydrogenase, geranylgeranyl reductase family Msm_1701 132 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 148642734 Nonpathogen - hypothetical protein Msm_0674 1 None None None 148643641 Common - excinuclease ABC, subunit A, UvrA Msm_1581 243 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 148642292 Nonpathogen - signal peptidase I Msm_0232 2 COG2932 COG2932, Predicted transcriptional regulator Transcription 148642518 Common - transposase, homeodomain-like superfamily Msm_0458 26 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 148642367 Common - sugar kinase (ribokinase/pfkB superfamily) Msm_0307 179 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 148643583 Common - transposase Msm_1523 31 None None None 148643331 Nonpathogen - DNA polymerase II small subunit Msm_1271 24 COG1311 HYS2, Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B DNA replication, recombination, and repair 148642362 Common - peptide/nickel ABC transporter, permease component, DppC Msm_0302 217 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 148642511 Common - hypothetical protein Msm_0451 22 None None None 148643783 Common - N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase Msm_1723 27 COG3252 COG3252, Methenyltetrahydromethanopterin cyclohydrolase Coenzyme metabolism 148643388 Common - glycosyltransferase, GT2 family Msm_1328 210 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 148643814 Common - predicted ATP-dependent protease La, Lon Msm_1754 41 COG4930 COG4930, Predicted ATP-dependent Lon-type protease Posttranslational modification, protein turnover, chaperones 148643568 Nonpathogen - hypothetical protein Msm_1508 1 None None None 148643091 Nonpathogen - N(2),N(2)-dimethylguanosine tRNA methyltransferase Msm_1031 38 COG1867 TRM1, N2,N2-dimethylguanosine tRNA methyltransferase Translation, ribosomal structure and biogenesis 148642594 Nonpathogen - putative IS element (transposase remnant) Msm_0534 1 None None None 148643606 Nonpathogen - hypothetical protein Msm_1546 1 None None None 148642113 Nonpathogen - tRNA CCA-pyrophosphorylase Msm_0053 34 COG1746 CCA1, tRNA nucleotidyltransferase (CCA-adding enzyme) Translation, ribosomal structure and biogenesis 148642947 Common - universal stress protein, adenine nucleotide alpha hydrolase-like family Msm_0887 99 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 148643417 Nonpathogen - exosome complex RNA-binding protein Csl4 Msm_1357 23 COG1096 COG1096, Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain) Translation, ribosomal structure and biogenesis 148642418 Nonpathogen - hypothetical protein Msm_0358 4 None None None 148642811 Common rpl14p 50S ribosomal protein L14P Msm_0751 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 148643169 Common - molecular chaperone DnaK Msm_1109 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 148642720 Common - LemA protein Msm_0660 131 COG1704 LemA, Uncharacterized conserved protein Function unknown 148643006 Common - phosphoglycolate phosphatase Msm_0946 112 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 148642727 Nonpathogen - hypothetical protein Msm_0667 1 None None None 148642778 Nonpathogen - hypothetical protein Msm_0718 2 None None None 148642330 Common - serine acetyltransferase, CysE Msm_0270 217 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 148643010 Common - molybdopterin biosynthesis protein, MoeA Msm_0950 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 148642358 Nonpathogen - 50S ribosomal protein L15e Msm_0298 34 COG1632 RPL15A, Ribosomal protein L15E Translation, ribosomal structure and biogenesis 148643693 Nonpathogen - hypothetical protein Msm_1633 7 COG2892 COG2892, Uncharacterized protein conserved in archaea Function unknown 148642819 Common rpl2p 50S ribosomal protein L2P Msm_0759 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 148642349 Common - phosphomethylpyrimidine kinase (HMPP-kinase), ThiD Msm_0289 221 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 148642211 Nonpathogen - hypothetical protein Msm_0151 1 None None None 148643073 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit D Msm_1013 14 COG4060 MtrD, Tetrahydromethanopterin S-methyltransferase, subunit D Coenzyme metabolism 148642763 Nonpathogen - ribosomal protein LX Msm_0703 14 COG2157 RPL20A, Ribosomal protein L20A (L18A) Translation, ribosomal structure and biogenesis 148642404 Nonpathogen - hypothetical protein Msm_0344 1 None None None 148642420 Common - cell wall biosynthesis protein, phospho-N-acetylmuramoyl-pentapeptide-transferase family Msm_0360 227 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 148643270 Common - efflux pump antibiotic resistance protein, MFS permease family Msm_1210 146 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 148642982 Nonpathogen - Fe-S oxidoreductase Msm_0922 33 COG0731 COG0731, Fe-S oxidoreductases Energy production and conversion 148643395 Nonpathogen - hypothetical protein Msm_1335 1 None None None 148642742 Nonpathogen - hypothetical protein Msm_0682 1 None None None 148643487 Common rps11p 30S ribosomal protein S11P Msm_1427 243 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 148643703 Nonpathogen - hypothetical protein Msm_1643 1 None None None 148643464 Common - formate dehydrogenase, alpha subunit, FdhA Msm_1404 202 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 148643131 Common - hydrogenase subunit F Msm_1071 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 148643632 Common - ADP-ribosylglycohydrolase Msm_1572 71 COG1397 DraG, ADP-ribosylglycohydrolase Posttranslational modification, protein turnover, chaperones 148642907 Common - 3-isopropylmalate dehydratase, small subunit, LeuD Msm_0847 206 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 148643745 Nonpathogen - hypothetical protein Msm_1685 1 None None None 148643542 Nonpathogen - hypothetical protein Msm_1482 1 None None None 148642873 Nonpathogen - hypothetical protein Msm_0813 14 COG4070 COG4070, Predicted peptidyl-prolyl cis-trans isomerase (rotamase), cyclophilin family Posttranslational modification, protein turnover, chaperones 148643235 Nonpathogen - hypothetical protein Msm_1175 1 None None None 148643269 Common - multimeric flavodoxin Msm_1209 39 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 148642145 Common - putative ferredoxin Msm_0085 35 COG1900 COG1900, Uncharacterized conserved protein Function unknown 148643584 Common - hypothetical protein Msm_1524 4 None None None 148643087 Common - Ca2+/Na+ antiporter (K+-dependent) Msm_1027 135 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 148643550 Nonpathogen - hypothetical protein Msm_1490 1 None None None 148643321 Common hisG ATP phosphoribosyltransferase Msm_1261 214 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 148642789 Common - molybdopterin biosynthesis protein, MoeB Msm_0729 223 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 148642089 Nonpathogen - putative calcium-binding protein Msm_0029 1 None None None 148643714 Common - putative Gp40-related protein, ERF family single-strand annealing protein (phage) Msm_1654 5 None None None 148642786 Nonpathogen - hypothetical protein Msm_0726 7 COG4073 COG4073, Uncharacterized protein conserved in archaea Function unknown 148642072 Common - hypothetical protein Msm_0012 5 None None None 148643567 Common - glycosyltransferase, GT2 family Msm_1507 172 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 148643215 Common - hypothetical protein Msm_1155 38 COG1786 COG1786, Uncharacterized conserved protein Function unknown 148642768 Nonpathogen - hypothetical protein Msm_0708 33 COG2118 COG2118, DNA-binding protein General function prediction only 148642123 Common - hypothetical protein Msm_0063 46 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 148643224 Common - translation-associated GTPase Msm_1164 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 148642933 Common - hypothetical protein Msm_0873 14 COG2457 COG2457, Uncharacterized conserved protein Function unknown 148643752 Nonpathogen - hypothetical protein Msm_1692 1 None None None 148642739 Nonpathogen - hypothetical protein Msm_0679 2 COG4640 COG4640, Predicted membrane protein Function unknown 148643062 Common - ABC transporter involved in Fe-S cluster assembly, permease component Msm_1002 188 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 148643100 Common - malate/L-lactate dehydrogenase Msm_1040 67 COG2055 COG2055, Malate/L-lactate dehydrogenases Energy production and conversion 148643246 Common - potassium transport system, membrane component, KefB Msm_1186 100 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 148643031 Common - methyl-coenzyme M reductase, component A2 Msm_0971 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 148642369 Nonpathogen - hypothetical protein Msm_0309 5 COG4030 COG4030, Uncharacterized protein conserved in archaea Function unknown 148642937 Nonpathogen - translation initiation factor IF-5A Msm_0877 34 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 148642619 Common - pyruvate:ferredoxin oxidoreductase, alpha subunit, PorA Msm_0559 122 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 148642459 Nonpathogen - hypothetical protein Msm_0399 1 None None None 148643544 Common - multidrug ABC transporter, permease component Msm_1484 138 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 148642806 Common rps8p 30S ribosomal protein S8P Msm_0746 238 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 148643166 Common - hydrogenase maturation factor, HypF Msm_1106 116 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 148643496 Common - ferredoxin Msm_1436 83 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 148643786 Nonpathogen - hypothetical protein Msm_1726 4 None None None 148642107 Common - chloramphenicol O-acetyltransferase Msm_0047 15 COG4845 COG4845, Chloramphenicol O-acetyltransferase Defense mechanisms 148643122 Common - energy-converting hydrogenase B, subunit O, EhbO Msm_1062 117 COG0650 HyfC, Formate hydrogenlyase subunit 4 Energy production and conversion 148643452 Common - formate dehydrogenase accessory protein FdhD, FdhD Msm_1392 134 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 148643015 Common - DNA topoisomerase VI subunit B Msm_0955 34 COG1389 COG1389, DNA topoisomerase VI, subunit B DNA replication, recombination, and repair 148643193 Common - translation initiation factor IF-2 subunit alpha Msm_1133 87 COG1093 SUI2, Translation initiation factor 2, alpha subunit (eIF-2alpha) Translation, ribosomal structure and biogenesis 148643446 Common - cytosine deaminase Msm_1386 206 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 148642813 Nonpathogen - ribonuclease P, subunit P29 Msm_0753 22 COG1588 POP4, RNase P/RNase MRP subunit p29 Translation, ribosomal structure and biogenesis 148643107 Nonpathogen - fibrillarin Msm_1047 34 COG1889 NOP1, Fibrillarin-like rRNA methylase Translation, ribosomal structure and biogenesis 148642713 Common - histidinol-phosphate aminotransferase Msm_0653 239 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 148642100 Nonpathogen - hypothetical protein Msm_0040 1 None None None 148642835 Common - transcriptional regulator, AraC family Msm_0775 115 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 148642912 Common - predicted ATP-utilizing enzyme Msm_0852 25 COG1821 COG1821, Predicted ATP-utilizing enzyme (ATP-grasp superfamily) General function prediction only 148642858 Nonpathogen - hypothetical protein Msm_0798 1 None None None 148642968 Common - DNA-directed RNA polymerase subunit A'' Msm_0908 89 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 148642996 Common - transcription regulator-related ATPase, ExsB Msm_0936 177 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 148643603 Nonpathogen - hypothetical protein Msm_1543 1 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 148643674 Common - predicted transcriptional regulator Msm_1614 132 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 148643688 Common - hypothetical protein Msm_1628 26 COG1891 COG1891, Uncharacterized protein conserved in archaea Function unknown 148642444 Nonpathogen nac nascent polypeptide-associated complex protein Msm_0384 32 COG1308 EGD2, Transcription factor homologous to NACalpha-BTF3 Transcription 148642466 Nonpathogen - hypothetical protein Msm_0406 3 COG2450 COG2450, Uncharacterized conserved protein Function unknown 148642992 Nonpathogen - hypothetical protein Msm_0932 31 COG1303 COG1303, Uncharacterized protein conserved in archaea Function unknown 148642690 Nonpathogen - hypothetical protein Msm_0630 15 COG4071 COG4071, Uncharacterized protein conserved in archaea Function unknown 148643346 Common - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase, UbiD Msm_1286 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 148642290 Nonpathogen - putative transposase Msm_0230 3 None None None 148643154 Common - conserved hypothetical integral membrane protein Msm_1094 Msm_1094 32 COG0392 COG0392, Predicted integral membrane protein Function unknown 148643437 Nonpathogen - 50S ribosomal protein L21e Msm_1377 27 COG2139 RPL21A, Ribosomal protein L21E Translation, ribosomal structure and biogenesis 148643361 Common - predicted Fe-S oxidoreductase Msm_1301 13 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 148643255 Common - xanthosine triphosphate pyrophosphatase, Ham1 family Msm_1195 233 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 148643651 Nonpathogen - hypothetical protein Msm_1591 27 COG2090 COG2090, Uncharacterized protein conserved in archaea Function unknown 148643356 Common ribH riboflavin synthase subunit beta Msm_1296 186 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 148642732 Nonpathogen - thiamine pyrophosphokinase Msm_0672 29 COG1634 COG1634, Uncharacterized Rossmann fold enzyme General function prediction only 148643482 Common - LemA protein Msm_1422 131 COG1704 LemA, Uncharacterized conserved protein Function unknown 148643727 Nonpathogen - hypothetical protein Msm_1667 1 None None None 148642255 Nonpathogen - hypothetical protein Msm_0195 29 COG1909 COG1909, Uncharacterized protein conserved in archaea Function unknown 148642450 Nonpathogen - hypothetical protein Msm_0390 1 None None None 148642497 Common - V-type ATP synthase subunit C Msm_0437 28 COG1527 NtpC, Archaeal/vacuolar-type H+-ATPase subunit C Energy production and conversion 148642632 Nonpathogen - H(2)-dependent methylenetetrahydromethanopterin dehydrogenase Msm_0572 6 COG4074 Mth, H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase Energy production and conversion 148643080 Nonpathogen - Fe-S oxidoreductase, Radical SAM family Msm_1020 14 COG1625 COG1625, Fe-S oxidoreductase, related to NifB/MoaA family Energy production and conversion 148643379 Nonpathogen - hypothetical protein Msm_1319 2 None None None 148642224 Common - conserved hypothetical protein predicted to be involved in DNA repair Msm_0164 Msm_0164 95 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 148642076 Nonpathogen - hypothetical protein Msm_0016 1 None None None 148642943 Common - orotate phosphoribosyltransferase Msm_0883 107 COG0856 COG0856, Orotate phosphoribosyltransferase homologs Nucleotide transport and metabolism 148643504 Common - hypothetical protein Msm_1444 8 COG4713 COG4713, Predicted membrane protein Function unknown 148642283 Nonpathogen - hypothetical protein Msm_0223 7 None None None 148642306 Nonpathogen - ribonuclease P, subunit Rpp14 Msm_0246 11 COG1369 POP5, RNase P/RNase MRP subunit POP5 Translation, ribosomal structure and biogenesis 148642394 Common - glutamyl-tRNA(Gln) amidotransferase subunit D Msm_0334 137 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 148643184 Common - coenzyme F420-reducing hydrogenase, alpha subunit, FrhA Msm_1124 108 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 148642859 Common - hypothetical protein Msm_0799 16 None None None 148642378 Nonpathogen - hypothetical protein Msm_0318 1 None None None 148643518 Nonpathogen - hypothetical protein Msm_1458 1 None None None 148642274 Common - threonine synthase Msm_0214 171 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 148642533 Nonpathogen - hypothetical protein Msm_0473 1 None None None 148643763 Nonpathogen - hypothetical protein Msm_1703 6 COG4026 COG4026, Uncharacterized protein containing TOPRIM domain, potential nuclease General function prediction only 148643198 Common - predicted glutamine amidotransferase, CobB/CobQ-like family Msm_1138 48 COG3442 COG3442, Predicted glutamine amidotransferase General function prediction only 148642679 Common alaS alanyl-tRNA synthetase Msm_0619 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 148642437 Common ispD 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Msm_0377 195 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 148642165 Nonpathogen - hypothetical protein Msm_0105 4 None None None 148642364 Common - peptide/nickel ABC transporter, ATP-binding component, DppF Msm_0304 249 COG1124 DppF, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 148642490 Common - hypothetical protein Msm_0430 15 COG3543 COG3543, Uncharacterized conserved protein Function unknown 148642091 Common - adhesin-like protein Msm_0031 13 None None None 148643205 Common - anthranilate/para-aminobenzoate synthase component II, TrpG Msm_1145 240 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 148642155 Nonpathogen - predicted phosphotransacetylase Msm_0095 14 COG4002 COG4002, Predicted phosphotransacetylase General function prediction only 148642484 Nonpathogen tfb transcription initiation factor IIB Msm_0424 34 COG1405 SUA7, Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB Transcription 148642472 Nonpathogen - putative adhesin-like protein Msm_0412 2 None None None 148642961 Common rps12P 30S ribosomal protein S12P Msm_0901 223 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 148642166 Common - hypothetical protein Msm_0106 22 COG1817 COG1817, Uncharacterized protein conserved in archaea Function unknown 148643238 Nonpathogen - putative ATPase implicated in cell cycle control Msm_1178 3 None None None 148643150 Common - sugar fermentation stimulation protein, SfsA Msm_1090 109 COG1489 SfsA, DNA-binding protein, stimulates sugar fermentation General function prediction only 148642173 Common - DNA helicase Msm_0113 228 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 148643320 Nonpathogen - histone Msm_1260 20 COG2036 HHT1, Histones H3 and H4 Chromatin structure and dynamics 148642824 Common - ribosomal L11 RNA methyltransferase (SAM-dependent) Msm_0764 37 COG2263 COG2263, Predicted RNA methylase Translation, ribosomal structure and biogenesis 148642905 Common - 2-methylthioadenine synthetase, MiaB Msm_0845 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 148642452 Common - indolepyruvate ferredoxin oxidoreductase, alpha subunit Msm_0392 117 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 148642233 Common - adhesin-like protein Msm_0173 106 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 148642241 Nonpathogen rpl37e 50S ribosomal protein L37e Msm_0181 29 COG2126 RPL37A, Ribosomal protein L37E Translation, ribosomal structure and biogenesis 148642262 Common - translation initiation factor IF-2 Msm_0202 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 148643533 Common - metal-dependent hydrolase, beta-lactamase superfamily Msm_1473 43 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 148642389 Common - DNA binding protein (regulator), xenobiotic response element family Msm_0329 80 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 148642063 Nonpathogen - hypothetical protein Msm_0003 1 None None None 148643628 Nonpathogen - putative transcription regulator Msm_1568 1 COG4738 COG4738, Predicted transcriptional regulator Transcription 148642521 Common - adhesin-like protein Msm_0461 25 None None None 148643662 Common - glycosyltransferase/CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase, GT2 family Msm_1602 109 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 148643021 Common - heavy-metal cation transporting ATPase Msm_0961 94 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 148643413 Nonpathogen - putative topoisomerase IV, subunit A Msm_1353 1 None None None 148643001 Common ubiA prenyltransferase Msm_0941 90 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 148642312 Common - Na+-driven multidrug efflux pump, NorM Msm_0252 181 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 148642427 Nonpathogen - hypothetical protein Msm_0367 12 COG4066 COG4066, Uncharacterized protein conserved in archaea Function unknown 148642231 Nonpathogen - hypothetical protein Msm_0171 4 None None None 148643821 Common - predicted ATPase involved in DNA repair Msm_1761 5 None None None 148642522 Nonpathogen - predicted metal-dependent protease, PAD1/JAB1 superfamily Msm_0462 22 COG1310 COG1310, Predicted metal-dependent protease of the PAD1/JAB1 superfamily General function prediction only 148643634 Common - nitroreductase, NfnB Msm_1574 55 COG0778 NfnB, Nitroreductase Energy production and conversion 148642676 Common - adhesin-like protein Msm_0616 123 None None None 148643179 Nonpathogen - hypothetical protein Msm_1119 3 None None None 148643338 Common - predicted ATPase, AAA+ superfamily Msm_1278 47 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 148642740 Common - predicted ATPase, AAA+ superfamily Msm_0680 50 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 148643373 Common - predicted glycosyltransferase (glycogen phosphorylase), GT1 family Msm_1313 48 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 148643643 Common - archaea-specific helicase Msm_1583 203 COG1202 COG1202, Superfamily II helicase, archaea-specific General function prediction only 148642984 Common - succinyl-CoA synthetase, beta subunit, SucC Msm_0924 208 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 148642871 Nonpathogen - hypothetical protein Msm_0811 14 COG4050 COG4050, Uncharacterized protein conserved in archaea Function unknown 148642927 Common - AMMECR1-related protein Msm_0867 78 COG2078 AMMECR1, Uncharacterized conserved protein Function unknown 148642371 Common - polyferredoxin, iron-sulfur binding Msm_0311 105 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 148642425 Nonpathogen - hypothetical protein Msm_0365 3 None None None 148643138 Common - predicted bile acid/sodium symporter Msm_1078 106 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 148642272 Nonpathogen - hypothetical protein Msm_0212 4 None None None 148642516 Common - hypothetical protein Msm_0456 96 COG0393 COG0393, Uncharacterized conserved protein Function unknown 148643617 Common - queuine/archaeosine tRNA-ribosyltransferase Msm_1557 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 148642758 Nonpathogen - hypothetical protein Msm_0698 1 None None None 148642920 Common argC N-acetyl-gamma-glutamyl-phosphate reductase Msm_0860 218 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 148643435 Nonpathogen - predicted RNA-binding protein Msm_1375 33 COG1491 COG1491, Predicted RNA-binding protein Translation, ribosomal structure and biogenesis 148643604 Common - lipopolysaccharide cholinephosphotransferase Msm_1544 16 COG3475 COG3475, LPS biosynthesis protein Cell envelope biogenesis, outer membrane 148642130 Nonpathogen - hypothetical protein Msm_0070 7 COG1771 COG1771, Uncharacterized protein conserved in archaea Function unknown 148642889 Common - aspartate-semialdehyde dehydrogenase Msm_0829 210 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 148643429 Common - MutT-related protein, NUDIX family Msm_1369 92 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 148643808 Common - predicted type II restriction enzyme, methylase subunit Msm_1748 27 None None None 148643555 Common - nuclease, Staphylococcus nuclease-like family Msm_1495 23 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 148643258 Common - O-sialoglycoprotein endopeptidase/protein kinase Msm_1198 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 148642210 Nonpathogen - hypothetical protein Msm_0150 1 None None None 148642079 Nonpathogen - hypothetical protein Msm_0019 1 None None None 148642840 Nonpathogen - hypothetical protein Msm_0780 2 COG3247 HdeD, Uncharacterized conserved protein Function unknown 148643012 Common - serine/threonine protein kinase, RIO1 family Msm_0952 66 COG1718 RIO1, Serine/threonine protein kinase involved in cell cycle control Signal transduction mechanisms / Cell division and chromosome partitioning 148643294 Common cbiC precorrin-8X methylmutase Msm_1234 118 COG2082 CobH, Precorrin isomerase Coenzyme metabolism 148643855 Common - predicted ATPase, AAA+ superfamily Msm_1795 53 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 148642603 Common - DNA repair photolyase, SplB Msm_0543 108 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 148643775 Common - magnesium chelatase subunit Msm_1715 89 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 148642249 Common - acetyl/acyl transferase related protein Msm_0189 183 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 148643148 Nonpathogen - hypothetical protein Msm_1088 1 None None None 148642680 Nonpathogen rpl12p 50S ribosomal protein L12P Msm_0620 23 COG2058 RPP1A, Ribosomal protein L12E/L44/L45/RPP1/RPP2 Translation, ribosomal structure and biogenesis 148643626 Nonpathogen - putative transposase Msm_1566 3 None None None 148642633 Common - biotin synthase Msm_0573 74 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 148642893 Nonpathogen rps17E 30S ribosomal protein S17e Msm_0833 32 COG1383 RPS17A, Ribosomal protein S17E Translation, ribosomal structure and biogenesis 148643058 Common - polyferredoxin, MvhB Msm_0998 168 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 148642848 Common - aspartate aminotransferase Msm_0788 241 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 148642950 Nonpathogen - hypothetical protein Msm_0890 1 None None None 148643593 Common - adhesin-like protein Msm_1533 10 None None None 148642629 Common - phosphate transport system regulator-like protein, PhoU Msm_0569 23 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 148642683 Common rpl11p 50S ribosomal protein L11P Msm_0623 229 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 148642882 Nonpathogen - photosynthetic reaction centre cytoplasmic domain-containing protein Msm_0822 4 COG1873 COG1873, Uncharacterized conserved protein Function unknown 148642656 Common - type II secretion system protein, GspF Msm_0596 48 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 148642723 Nonpathogen - dinitrogenase iron-molybdenum cofactor biosynthesis protein, NifX_NifB family Msm_0663 8 COG1433 COG1433, Uncharacterized conserved protein Function unknown 148643852 Common - hypothetical protein Msm_1792 23 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 148642702 Common - cell division control protein Cdc48, AAA+ ATPase family Msm_0642 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 148642342 Common - adhesin-like protein Msm_0282 14 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 148642140 Common - sulfopyruvate decarboxylase, comD Msm_0080 34 COG4032 COG4032, Predicted thiamine-pyrophosphate-binding protein General function prediction only 148642620 Common - pyruvate ferredoxin oxidoreductase subunit beta Msm_0560 134 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 148643586 Common - hypothetical protein Msm_1526 19 COG1300 SpoIIM, Uncharacterized membrane protein Function unknown 148642268 Nonpathogen - predicted DNA-binding protein Msm_0208 1 None None None 148643114 Common - IMP dehydrogenase related protein Msm_1054 154 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 148642323 Common - nitrogen fixation protein, NifU Msm_0263 169 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 148642508 Common - hypothetical protein Msm_0448 10 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 148643475 Nonpathogen - hypothetical protein Msm_1415 3 COG4013 COG4013, Uncharacterized protein conserved in archaea Function unknown 148642780 Nonpathogen - transcription factor Msm_0720 34 COG2101 SPT15, TATA-box binding protein (TBP), component of TFIID and TFIIIB Transcription 148643267 Common - molybdate transport system regulatory protein Msm_1207 10 COG2005 ModE, N-terminal domain of molybdenum-binding protein General function prediction only 148642413 Nonpathogen - hypothetical protein Msm_0353 2 None None None 148643540 Common - predicted hydrolase, HAD superfamily Msm_1480 102 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 148643679 Common - cobalt transport protein CbiN Msm_1619 18 COG1930 CbiN, ABC-type cobalt transport system, periplasmic component Inorganic ion transport and metabolism 148643002 Nonpathogen - hypothetical protein Msm_0942 3 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 148643133 Nonpathogen - hypothetical protein Msm_1073 14 COG1563 COG1563, Predicted subunit of the Multisubunit Na+/H+ antiporter Inorganic ion transport and metabolism 148643019 Common - hypothetical protein Msm_0959 94 COG1937 COG1937, Uncharacterized protein conserved in bacteria Function unknown 148643430 Common - hypothetical protein Msm_1370 12 COG3274 COG3274, Uncharacterized protein conserved in bacteria Function unknown 148643792 Nonpathogen - hypothetical protein Msm_1732 1 None None None 148642909 Common - molybdenum cofactor biosynthesis-related protein, MoaA Msm_0849 201 COG1964 COG1964, Predicted Fe-S oxidoreductases General function prediction only 148643038 Common - biopolymer transport protein, MotA/TolQ/ExbB proton channel family Msm_0978 115 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 148643744 Common - phage-related minor tail protein Msm_1684 10 COG5412 COG5412, Phage-related protein Function unknown 148642543 Nonpathogen - hypothetical protein Msm_0483 2 None None None 148643129 Nonpathogen - energy-converting hydrogenase B, subunit H, EhbH Msm_1069 5 None None None 148643140 Nonpathogen - predicted deacylase Msm_1080 3 COG3608 COG3608, Predicted deacylase General function prediction only 148642351 Common - nitrate/sulfonate/bicarbonate ABC transporter, permease component, TauC Msm_0291 203 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 148643233 Common - tRNA(1-methyladenosine) methyltransferase Msm_1173 70 COG2519 GCD14, tRNA(1-methyladenosine) methyltransferase and related methyltransferases Translation, ribosomal structure and biogenesis 148643549 Nonpathogen - formylmethanofuran dehydrogenase subunit E, metal-binding Msm_1489 8 COG5643 COG5643, Protein containing a metal-binding domain shared with formylmethanofuran dehydrogenase subunit E General function prediction only 148643251 Common - cell wall biosynthesis protein, MurD-like peptide ligase family Msm_1191 52 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 148642435 Common - acetylglutamate kinase Msm_0375 226 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 148643561 Nonpathogen - signal recognition particle, subunit SRP19 Msm_1501 26 COG1400 SEC65, Signal recognition particle 19 kDa protein Intracellular trafficking and secretion 148642125 Common - hypothetical protein Msm_0065 216 COG1985 RibD, Pyrimidine reductase, riboflavin biosynthesis Coenzyme metabolism 148643089 Common - hypothetical protein Msm_1029 43 COG0011 COG0011, Uncharacterized conserved protein Function unknown 148642749 Nonpathogen - hypothetical protein Msm_0689 1 None None None 148643619 Common - polysaccharide biosynthesis protein, MviN-like family Msm_1559 109 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 148642860 Nonpathogen - hypothetical protein Msm_0800 1 None None None 148643516 Common - hypothetical protein Msm_1456 3 None None None 148643276 Nonpathogen - hypothetical protein Msm_1216 6 COG1822 COG1822, Predicted archaeal membrane protein Function unknown 148642776 Common - oligosaccharyl transferase, STT3 subunit Msm_0716 13 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 148642083 Common - uncharacterized protein predicted to be involved in DNA repair Msm_0023 104 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 148642406 Nonpathogen - hypothetical protein Msm_0346 32 COG1602 COG1602, Uncharacterized conserved protein Function unknown 148643319 Common - predicted metal-dependent hydrolase, TRZ/ATZ family (xenobiotic metabolism) Msm_1259 185 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 148642110 Common - predicted metal-binding protein Msm_0050 5 COG5423 COG5423, Predicted metal-binding protein Function unknown 148642865 Common - polar amino acid ABC transporter, ATPase component Msm_0805 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 148642592 Nonpathogen - putative IS element (transposase remnant) Msm_0532 1 None None None 148642139 Common - CofH protein (7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO)/F420 biosynthesis) Msm_0079 81 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 148643407 Nonpathogen - hypothetical protein Msm_1347 1 None None None 148642725 Common - 5'-methylthioadenosine phosphorylase Msm_0665 168 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 148643386 Common - polysaccharide/polyol phosphate ABC transporter, ATPase component Msm_1326 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 148643120 Nonpathogen - energy-converting hydrogenase B, subunit Q, EhbQ Msm_1060 15 COG1707 COG1707, ACT domain-containing protein General function prediction only 148643705 Common - virulence protein Msm_1645 61 COG3943 COG3943, Virulence protein General function prediction only 148642553 Common - mechanosensitive ion channel protein, Sm-like ribonucleoprotein superfamily, MscS Msm_0493 232 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 148642669 Nonpathogen - ferredoxin, iron-sulfur binding Msm_0609 2 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 148643074 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit E Msm_1014 14 COG4059 MtrE, Tetrahydromethanopterin S-methyltransferase, subunit E Coenzyme metabolism 148642354 Nonpathogen - hypothetical protein Msm_0294 1 None None None 148642941 Common - porphobilinogen deaminase Msm_0881 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 148642989 Common - fumarate hydratase, FumA Msm_0929 131 COG1838 FumA, Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain Energy production and conversion 148642213 Common - cofactor-independent phosphoglycerate mutase Msm_0153 53 COG3635 COG3635, Predicted phosphoglycerate mutase, AP superfamily Carbohydrate transport and metabolism 148643804 Common - predicted type II restriction enzyme, methylase subunit Msm_1744 14 None None None 148643552 Common - hydrogenase maturation factor, HypE Msm_1492 197 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 148643094 Nonpathogen - hypothetical protein Msm_1034 5 COG4077 COG4077, Uncharacterized protein conserved in archaea Function unknown 148643836 Nonpathogen - TPR repeat protein Msm_1776 2 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 148643177 Common - cobalamin biosynthesis protein N, CobN Msm_1117 89 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 148643812 Common - predicted restriction endonuclease Msm_1752 4 COG4293 COG4293, Uncharacterized protein conserved in bacteria Function unknown 148643819 Nonpathogen - hypothetical protein Msm_1759 1 None None None 148642539 Nonpathogen - Zn-dependent protease, peptidase M50 family Msm_0479 29 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 148642877 Nonpathogen - predicted transcriptional regulator Msm_0817 11 COG4742 COG4742, Predicted transcriptional regulator Transcription 148643218 Common - hydrogenase expression/formation protein, HypE Msm_1158 57 COG1973 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 148642567 Common - predicted phosphoesterase, YfcE Msm_0507 88 COG0622 COG0622, Predicted phosphoesterase General function prediction only 148643077 Nonpathogen - methyl-coenzyme M reductase, C subunit, McrC Msm_1017 14 COG4056 McrC, Methyl coenzyme M reductase, subunit C Coenzyme metabolism 148642216 Nonpathogen gatC aspartyl/glutamyl-tRNA amidotransferase subunit C Msm_0156 4 None None None 148643459 Common - adhesin-like protein Msm_1399 24 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 148643328 Nonpathogen - hypothetical protein Msm_1268 28 COG1698 COG1698, Uncharacterized protein conserved in archaea Function unknown 148643522 Nonpathogen - formate dehydrogenase, beta subunit, FdhB Msm_1462 33 COG1035 FrhB, Coenzyme F420-reducing hydrogenase, beta subunit Energy production and conversion 148643478 Common - glutamine synthetase, GlnA Msm_1418 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 148643818 Nonpathogen - hypothetical protein Msm_1758 1 None None None 148642750 Common - helicase Msm_0690 152 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 148643512 Common gltX glutamyl-tRNA synthetase Msm_1452 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 148642341 Nonpathogen - putative adhesin-like protein Msm_0281 13 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 148642180 Common - purine NTPase involved in DNA repair, Rad50 Msm_0120 169 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 148642337 Common pheT phenylalanyl-tRNA synthetase subunit beta Msm_0277 178 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 148643554 Nonpathogen - hypothetical protein Msm_1494 1 None None None 148642504 Nonpathogen - hypothetical protein Msm_0444 1 None None None 148643397 Common glyA serine hydroxymethyltransferase Msm_1337 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 148643803 Common - predicted type II restriction enzyme, methylase subunit Msm_1743 36 None None None 148643843 Nonpathogen - hypothetical protein Msm_1783 1 None None None 148642116 Common - fructose-bisphosphate aldolase Msm_0056 96 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 148643013 Common - hypothetical protein Msm_0953 46 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 148643187 Common - cation transport ATPase, HAD family Msm_1127 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 148642748 Common - 4-oxalocrotonate tautomerase Msm_0688 6 COG1942 COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog General function prediction only 148642127 Common - hypothetical protein Msm_0067 2 None None None 148643546 Nonpathogen - 30S ribosomal protein S8e Msm_1486 34 COG2007 RPS8A, Ribosomal protein S8E Translation, ribosomal structure and biogenesis 148643253 Common - single-stranded DNA-specific exonuclease, DHH family Msm_1193 39 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 148643807 Common - predicted type II restriction enzyme, methylase subunit Msm_1747 32 None None None 148642730 Common - hypothetical protein Msm_0670 11 None None None 148642585 Common - predicted unusual protein kinase, ubiquinone biosynthesis protein-related, AarF Msm_0525 185 COG0661 AarF, Predicted unusual protein kinase General function prediction only 148643471 Nonpathogen - tungsten formylmethanofuran dehydrogenase, subunit D, FwdD Msm_1411 15 COG1153 FwdD, Formylmethanofuran dehydrogenase subunit D Energy production and conversion 148643601 Nonpathogen - hypothetical protein Msm_1541 1 None None None 148642135 Nonpathogen - DNA primase small subunit Msm_0075 30 COG1467 PRI1, Eukaryotic-type DNA primase, catalytic (small) subunit DNA replication, recombination, and repair 148643273 Common - bifunctional formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase Msm_1213 59 COG1795 COG1795, Uncharacterized conserved protein Function unknown 148643265 Nonpathogen - hypothetical protein Msm_1205 1 COG3548 COG3548, Predicted integral membrane protein Function unknown 148643305 Nonpathogen - DNA-binding protein, AlbA Msm_1245 28 COG1581 Ssh10b, Archaeal DNA-binding protein Transcription 148642757 Nonpathogen - hypothetical protein Msm_0697 1 None None None 148642061 Common - exoribonuclease VII, large subunit, XseA Msm_0001 198 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 148642815 Common - ribosomal protein L29p Msm_0755 34 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 148642722 Nonpathogen - putative flagellar protein, FliL Msm_0662 1 None None None 148643156 Common - Trk-type potassium transport system, NAD-binding component, TrkA Msm_1096 182 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 148643134 Nonpathogen - putative monovalent cation/H+ antiporter subunit G Msm_1074 4 COG1320 MnhG, Multisubunit Na+/H+ antiporter, MnhG subunit Inorganic ion transport and metabolism 148643636 Nonpathogen - hypothetical protein Msm_1576 1 None None None 148643709 Nonpathogen - hypothetical protein Msm_1649 1 None None None 148643244 Common - sugar phosphate isomerase/epimerase, AP endonuclease family 2 Msm_1184 52 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 148643231 Common - ammonia-dependent NAD+ synthetase, NadE Msm_1171 231 COG0171 NadE, NAD synthase Coenzyme metabolism 148642239 Nonpathogen - hypothetical protein Msm_0179 1 None None None 148643439 Common - predicted NADP-dependent alcohol dehydrogenase Msm_1379 15 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 148642872 Nonpathogen - hypothetical protein Msm_0812 14 COG4029 COG4029, Uncharacterized protein conserved in archaea Function unknown 148642414 Common - proteasome-activating nucleotidase Msm_0354 249 COG1222 RPT1, ATP-dependent 26S proteasome regulatory subunit Posttranslational modification, protein turnover, chaperones 148642785 Nonpathogen - flap endonuclease-1 Msm_0725 34 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 148642765 Nonpathogen - 50S ribosomal protein L31e Msm_0705 32 COG2097 RPL31A, Ribosomal protein L31E Translation, ribosomal structure and biogenesis 148643261 Common - undecaprenyl-diphosphatase, UppP Msm_1201 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 148642356 Nonpathogen - putative carboxymuconolactone decarboxylase Msm_0296 10 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 148643147 Common - NAD-dependent deacetylase Msm_1087 151 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 148642782 Common aksA trans-homoaconitate synthase Msm_0722 220 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 148643111 Nonpathogen - putative endoglucanase Msm_1051 2 None None None 148643296 Common aspC aspartyl-tRNA synthetase Msm_1236 249 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 148643353 Common - nitroreductase, NADH oxidase/flavin reductase family Msm_1293 66 COG0778 NfnB, Nitroreductase Energy production and conversion 148642841 Nonpathogen - hypothetical protein Msm_0781 3 None None None 148642956 Common - precorrin-6X reductase, CbiJ Msm_0896 54 COG2099 CobK, Precorrin-6x reductase Coenzyme metabolism 148643426 Common - lactoylglutathione lyase, LglU Msm_1366 35 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 148642230 Nonpathogen - conserved hypothetical protein predicted to be involved in DNA repair Msm_0170 Msm_0170 24 COG1583 COG1583, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 148642624 Common - phosphate uptake regulator, PhoU Msm_0564 178 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 148642878 Nonpathogen - predicted transcriptional regulator Msm_0818 11 COG4742 COG4742, Predicted transcriptional regulator Transcription 148643285 Common - acetolactate synthase catalytic subunit Msm_1225 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 148643042 Common - phosphatidylserine synthase, PssA Msm_0982 144 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 148643335 Nonpathogen - mgtE-like divalent cation transporter Msm_1275 17 COG1824 COG1824, Permease, similar to cation transporters Inorganic ion transport and metabolism 148642608 Common - 6-phosphogluconate dehydrogenase, beta-hydroxyacid dehydrogenase related, MmsB Msm_0548 18 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 148643290 Common - transcriptional regulator, MarR family Msm_1230 36 COG1846 MarR, Transcriptional regulators Transcription 148642952 Nonpathogen - putative zinc-binding protein Msm_0892 4 COG4640 COG4640, Predicted membrane protein Function unknown 148642838 Common - predicted RNA-binding protein, eukaryotic snRNP-like protein Msm_0778 58 COG1293 COG1293, Predicted RNA-binding protein homologous to eukaryotic snRNP Transcription 148643234 Common - heat shock protein HtpX (Zn-dependent) Msm_1174 191 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 148642849 Common - cation efflux system protein (zinc/cadmium/cobalt) Msm_0789 215 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 148643055 Common - adhesin-like protein Msm_0995 25 None None None 148643382 Common - glycosyltransferase (glycogen phosphorylase), GT1 family Msm_1322 30 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 148643589 Common - putative Zn peptidase Msm_1529 3 COG2856 COG2856, Predicted Zn peptidase Amino acid transport and metabolism 148642658 Nonpathogen - SAM-dependent methyltransferase Msm_0598 9 COG1867 TRM1, N2,N2-dimethylguanosine tRNA methyltransferase Translation, ribosomal structure and biogenesis 148643770 Common - seryl-tRNA synthetase, SerS Msm_1710 244 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 148642729 Nonpathogen - hypothetical protein Msm_0669 1 None None None 148642147 Nonpathogen - putative transposase Msm_0087 3 None None None 148643695 Nonpathogen - hypothetical protein Msm_1635 2 None None None 148642308 Nonpathogen - hypothetical protein Msm_0248 1 None None None 148643289 Common - Na+-driven multidrug efflux pump Msm_1229 129 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 148643850 Common - predicted ATPase, AAA+ superfamily Msm_1790 34 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 148643009 Common - transcriptional activator Msm_0949 6 COG4978 COG4978, Transcriptional regulator, effector-binding domain/component Transcription / Signal transduction mechanisms 148642109 Common - F420-dependent NADP oxidoreductase, fno Msm_0049 39 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 148643748 Nonpathogen - hypothetical protein Msm_1688 1 None None None 148642556 Common - homoserine O-acetyltransferase Msm_0496 119 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 148643788 Nonpathogen - hypothetical protein Msm_1728 1 COG4925 COG4925, Uncharacterized conserved protein Function unknown 148642333 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Msm_0273 227 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 148643823 Nonpathogen - predicted DNA-directed RNA polymerase, subunit M, RpoM Msm_1763 3 COG1594 RPB9, DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS Transcription 148642296 Common - phosphohydrolase (HD superfamily) Msm_0236 90 COG1078 COG1078, HD superfamily phosphohydrolases General function prediction only 148642401 Nonpathogen - hypothetical protein Msm_0341 1 None None None 148643297 Common - dihydroxy-acid dehydratase, IlvD Msm_1237 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 148643336 Nonpathogen - hypothetical protein Msm_1276 2 None None None 148642550 Common - SAM-dependent methyltransferase, UbiE/CobQ family Msm_0490 29 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 148642198 Common - predicted exonuclease Msm_0138 27 COG3359 COG3359, Predicted exonuclease DNA replication, recombination, and repair 148643118 Nonpathogen - hypothetical protein Msm_1058 18 COG1665 COG1665, Uncharacterized protein conserved in archaea Function unknown 148643404 Nonpathogen - predicted membrane-associated Zn-dependent protease Msm_1344 34 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 148643811 Common - hypothetical protein Msm_1751 32 None None None 148643538 Common pheS phenylalanyl-tRNA synthetase subunit alpha Msm_1478 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 148642564 Nonpathogen - hypothetical protein Msm_0504 1 None None None 148643268 Common - teichoic acid transporter Msm_1208 130 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 148643669 Common - molybdate ABC transporter, substrate-binding component, ModA Msm_1609 159 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 148643214 Common - metal-dependent amidohydrolase Msm_1154 98 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 148643152 Common - tetrahydromethanopterin formyltransferase Msm_1092 24 COG2037 Ftr, Formylmethanofuran:tetrahydromethanopterin formyltransferase Energy production and conversion 148642895 Nonpathogen - shikimate kinase Msm_0835 26 COG1685 COG1685, Archaeal shikimate kinase Amino acid transport and metabolism / Coenzyme metabolism 148642408 Nonpathogen - hypothetical protein Msm_0348 3 COG1617 COG1617, Uncharacterized conserved protein Function unknown 148643167 Nonpathogen - predicted transcriptional regulator Msm_1107 17 COG1777 COG1777, Predicted transcriptional regulators Transcription 148643052 Nonpathogen - hypothetical protein Msm_0992 3 None None None 148642662 Nonpathogen ef1B elongation factor 1-beta Msm_0602 14 COG2092 EFB1, Translation elongation factor EF-1beta Translation, ribosomal structure and biogenesis 148643798 Nonpathogen - putative adhesin-like protein Msm_1738 1 None None None 148642428 Common - glutamate synthase (NADPH), subunit 2 Msm_0368 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 148642670 Common - aspartate aminotransferase Msm_0610 237 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 148642515 Nonpathogen - hypothetical protein Msm_0455 4 None None None 148643712 Nonpathogen - hypothetical protein Msm_1652 1 None None None 148642807 Nonpathogen rps14P 30S ribosomal protein S14P Msm_0747 33 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 148642492 Nonpathogen - hypothetical protein Msm_0432 1 None None None 148642737 Common - aspartate aminotransferase Msm_0677 178 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 148642248 Common - rubredoxin Msm_0188 114 COG1773 COG1773, Rubredoxin Energy production and conversion 148642599 Nonpathogen - putative DNA-directed DNA polymerase Msm_0539 1 None None None 148642800 Nonpathogen rpl30p 50S ribosomal protein L30P Msm_0740 34 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 148643449 Common - sugar kinase, ribokinase/pfkB superfamily Msm_1389 165 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 148643534 Common - chorismate synthase Msm_1474 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 148642399 Nonpathogen - hypothetical protein Msm_0339 1 None None None 148642648 Common - ferrous iron transport protein A, FeoA Msm_0588 53 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 148642641 Nonpathogen - hypothetical protein Msm_0581 7 COG1822 COG1822, Predicted archaeal membrane protein Function unknown 148642836 Nonpathogen - hypothetical protein Msm_0776 22 COG3356 COG3356, Predicted membrane protein Function unknown 148642279 Common - putative cysteine protease (transglutaminase-like superfamily) Msm_0219 40 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 148643484 Common - polyphosphate kinase Msm_1424 161 COG0855 Ppk, Polyphosphate kinase Inorganic ion transport and metabolism 148642555 Nonpathogen - hypothetical protein Msm_0495 2 None None None 148642175 Common - hypothetical protein Msm_0115 25 COG2043 COG2043, Uncharacterized protein conserved in archaea Function unknown 148642098 Nonpathogen - hypothetical protein Msm_0038 1 None None None 148643023 Common - endonuclease IV, xylose isomerase-like TIM barrel family, Nfo Msm_0963 29 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 148643707 Nonpathogen - hypothetical protein Msm_1647 1 None None None 148642499 Common - vacuolar-type H+-transporting ATP synthase, subunit K Msm_0439 21 None None None 148642689 Nonpathogen - putative transposase Msm_0629 4 None None None 148643188 Nonpathogen - hypothetical protein Msm_1128 1 None None None 148642196 Common - putative ferredoxin Msm_0136 14 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 148643779 Nonpathogen - hypothetical protein Msm_1719 7 COG4744 COG4744, Uncharacterized conserved protein Function unknown 148642560 Common - N-carbamoyl-D-amino acid amidohydrolase Msm_0500 207 COG0388 COG0388, Predicted amidohydrolase General function prediction only 148643725 Nonpathogen - hypothetical protein Msm_1665 1 None None None 148643766 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Msm_1706 13 None None None 148643004 Common - CMP-N-acetylneuraminic acid synthetase, NeuA Msm_0944 76 COG1083 NeuA, CMP-N-acetylneuraminic acid synthetase Cell envelope biogenesis, outer membrane 148643737 Nonpathogen - putative major capsid protein gp5 (phage psiM2) Msm_1677 3 None None None 148642170 Nonpathogen - predicted transposase Msm_0110 4 None None None 148643724 Nonpathogen - hypothetical protein Msm_1664 1 None None None 148643664 Common - UDP-glucose pyrophosphorylase, GalU Msm_1604 234 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 148642698 Nonpathogen - cell wall biosynthesis protein, UDP-glycosyltransferase family Msm_0638 3 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 148642313 Common - hypothetical protein Msm_0253 8 None None None 148642321 Nonpathogen - hypothetical protein Msm_0261 2 None None None 148642925 Common - putative glucose-methanol-choline oxidoreductase (FAD-dependent) Msm_0865 21 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 148643303 Nonpathogen - putative actin-like ATPase Msm_1243 12 COG4012 COG4012, Uncharacterized protein conserved in archaea Function unknown 148642286 Nonpathogen - hypothetical protein Msm_0226 1 None None None 148643742 Nonpathogen - hypothetical protein Msm_1682 1 None None None 148642531 Common - type II secretion system protein F, GspF Msm_0471 40 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 148643468 Common - tungsten formylmethanofuran dehydrogenase, subunit E, FwdE Msm_1408 36 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 148642392 Common - 2-ketoisovalerate ferredoxin reductase Msm_0332 119 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 148643181 Common - coenzyme F420-reducing hydrogenase subunit beta Msm_1121 37 COG1035 FrhB, Coenzyme F420-reducing hydrogenase, beta subunit Energy production and conversion 148642826 Common - biotin-[acetyl-CoA-carboxylase] ligase/biotin operon regulator bifunctional protein, BirA Msm_0766 227 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 148642458 Common - uracil phosphoribosyltransferase, Upp Msm_0398 164 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 148642506 Common - citrate synthase Msm_0446 179 COG0372 GltA, Citrate synthase Energy production and conversion 148643699 Common - heavy metal cation (Co/Zn/Cd) efflux system protein, CzcD family Msm_1639 164 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 148642434 Common - long-chain fatty-acid-CoA ligase (AMP-forming), CaiC Msm_0374 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 148643629 Common - ATP-dependent protease La, LonB Msm_1569 199 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 148643196 Nonpathogen - hypothetical protein Msm_1136 3 COG1711 COG1711, Uncharacterized protein conserved in archaea Function unknown 148642301 Common - exosome complex RNA-binding protein Rrp42 Msm_0241 46 COG2123 COG2123, RNase PH-related exoribonuclease Translation, ribosomal structure and biogenesis 148642082 Nonpathogen - hypothetical protein Msm_0022 1 None None None 148642916 Common - antimicrobial peptide ABC transporter, permease component Msm_0856 55 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 148642251 Nonpathogen - hypothetical protein Msm_0191 1 None None None 148642578 Common - methylcobalamin:coenzyme M methyltransferase, MtaA Msm_0518 27 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 148642137 Common - thymidylate kinase Msm_0077 14 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 148642635 Nonpathogen - hypothetical protein Msm_0575 7 COG4017 COG4017, Uncharacterized protein conserved in archaea Function unknown 148642771 Nonpathogen - ribonuclease P, subunit RPR2 Msm_0711 20 COG2023 RPR2, RNase P subunit RPR2 Translation, ribosomal structure and biogenesis 148642621 Common - formate dehydrogenase, iron-sulfur subunit Msm_0561 151 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 148643083 Common - 2-phosphosulpholactate phosphatase, ComB, (coenzyme M biosynthesis) Msm_1023 44 COG2045 COG2045, Phosphosulfolactate phosphohydrolase and related enzymes Coenzyme metabolism / General function prediction only 148643402 Common - phosphoribosylformylglycinamidine (FGAM) synthase, PurL Msm_1342 234 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 148643789 Nonpathogen - hypothetical protein Msm_1729 1 None None None 148643060 Common - methyl viologen-reducing hydrogenase, gamma subunit, MvhG Msm_1000 52 COG1941 FrhG, Coenzyme F420-reducing hydrogenase, gamma subunit Energy production and conversion 148642386 Nonpathogen - hypothetical protein Msm_0326 2 COG4042 COG4042, Predicted membrane protein Function unknown 148642735 Nonpathogen - hypothetical protein Msm_0675 1 None None None 148642583 Common - collagenase, peptidase family U32 Msm_0523 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 148643845 Common - hypothetical protein Msm_1785 3 None None None 148642614 Common - protein containing von Willebrand factor type A (vWA) domain, CoxE Msm_0554 35 COG3552 CoxE, Protein containing von Willebrand factor type A (vWA) domain General function prediction only 148643612 Nonpathogen - hypothetical protein Msm_1552 1 None None None 148643204 Common - anthranilate phosphoribosyltransferase, TrpD Msm_1144 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 148643036 Nonpathogen - IMP cyclohydrolase Msm_0976 13 COG3363 COG3363, Archaeal IMP cyclohydrolase Nucleotide transport and metabolism 148642206 Nonpathogen - type IV leader peptidase Msm_0146 8 COG4960 CpaA, Flp pilus assembly protein, protease CpaA Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 148642532 Common - Xaa-Pro aminopeptidase Msm_0472 247 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 148642445 Common - anaerobic magnesium-protoporphyrin IX monomethyl ester cyclase, Elongator protein 3/MiaB/NifB family Msm_0385 118 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 148643502 Common - predicted RNA hydrolase, metallo-beta-lactamase superfamily Msm_1442 157 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 148643047 Common - tyrosine decarboxylase, MfnA Msm_0987 153 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 148643529 Common - nitrate/sulfonate/bicarbonate ABC transporter, substrate-binding component, TauA Msm_1469 121 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 148643158 Nonpathogen - holliday junction resolvase Msm_1098 22 COG1591 COG1591, Holliday junction resolvase - archaeal type DNA replication, recombination, and repair 148643627 Common - adhesin-like protein Msm_1567 36 COG1520 COG1520, FOG: WD40-like repeat Function unknown 148642463 Common - glycyl-tRNA synthetase Msm_0403 88 COG0423 GRS1, Glycyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 148642855 Common - heterodisulfide reductase, subunit B, HdrB Msm_0795 88 COG2048 HdrB, Heterodisulfide reductase, subunit B Energy production and conversion 148642999 Common - pyruvate carboxylase subunit B Msm_0939 220 COG5016 COG5016, Pyruvate/oxaloacetate carboxyltransferase Energy production and conversion 148643473 Common - tungsten formylmethanofuran dehydrogenase, subunit A, FwdA Msm_1413 24 COG1229 FwdA, Formylmethanofuran dehydrogenase subunit A Energy production and conversion 148643162 Common - IMP dehydrogenase related protein Msm_1102 201 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 148643349 Common - GtrA-like surface polysaccharide biosynthesis protein, GtrA Msm_1289 5 COG2246 COG2246, Predicted membrane protein Function unknown 148643375 Common - predicted transcriptional regulator Msm_1315 69 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 148643190 Nonpathogen - hypothetical protein Msm_1130 14 COG4050 COG4050, Uncharacterized protein conserved in archaea Function unknown 148643658 Common - SAM-dependent methyltransferase Msm_1598 25 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 148643199 Common - cell wall biosynthesis protein, MurD-like peptide ligase family Msm_1139 57 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 148643209 Nonpathogen - hypothetical protein Msm_1149 5 None None None 148642884 Common - putative N-acetyltransferase, GNAT family Msm_0824 47 COG0456 RimI, Acetyltransferases General function prediction only 148643573 Common - aspartate aminotransferase Msm_1513 164 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 148643368 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Msm_1308 168 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 148642524 Common - L-aspartate dehydrogenase Msm_0464 49 COG1712 COG1712, Predicted dinucleotide-utilizing enzyme General function prediction only 148642930 Common - molecular chaperone (small heat shock protein), HSP20/alpha crystallin family Msm_0870 94 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 148643063 Common - ABC transporter involved in Fe-S cluster assembly, ATPase component Msm_1003 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 148643211 Common - adenylosuccinate lyase Msm_1151 241 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 148642346 Common - glycerol 1-phosphate dehydrogenase (Dehydroquinate synthase-like family) Msm_0286 123 COG0371 GldA, Glycerol dehydrogenase and related enzymes Energy production and conversion 148642995 Common - hypothetical protein Msm_0935 64 COG1641 COG1641, Uncharacterized conserved protein Function unknown 148643574 Common - glycerol-3-phosphate cytidyltransferase, TagD Msm_1514 48 COG0615 TagD, Cytidylyltransferase Cell envelope biogenesis, outer membrane / Lipid metabolism 148642796 Nonpathogen - hypothetical protein Msm_0736 24 COG1422 COG1422, Predicted membrane protein Function unknown 148642611 Common - hypothetical protein Msm_0551 40 COG1578 COG1578, Uncharacterized conserved protein Function unknown 148642258 Common - inorganic pyrophosphatase Msm_0198 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 148643411 Common - precorrin-2 C20-methyltransferase, CbiL Msm_1351 140 COG2243 CobF, Precorrin-2 methylase Coenzyme metabolism 148643351 Common - hypothetical protein Msm_1291 9 COG4713 COG4713, Predicted membrane protein Function unknown 148643754 Common - predicted helicase Msm_1694 89 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 148643102 Common - predicted permease Msm_1042 207 COG0628 PerM, Predicted permease General function prediction only 148643178 Nonpathogen - hypothetical protein Msm_1118 3 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 148643307 Common - serine/threonine protein kinase related protein (PQQ-binding) Msm_1247 101 COG1520 COG1520, FOG: WD40-like repeat Function unknown 148642103 Common - peptide methionine sulfoxide reductase, PMSR (protein repair; stress) Msm_0043 206 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 148643644 Nonpathogen - predicted excinuclease ABC, C subunit, UvrC Msm_1584 40 COG1833 COG1833, Uncharacterized conserved protein Function unknown 148643170 Common - molecular chaperone DnaJ Msm_1110 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 148643514 Common - predicted ATPase, AAA+ family Msm_1454 2 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 148643241 Common hisS histidyl-tRNA synthetase Msm_1181 249 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 148642133 Nonpathogen - DNA primase large subunit Msm_0073 5 COG2219 PRI2, Eukaryotic-type DNA primase, large subunit DNA replication, recombination, and repair 148642675 Common - fructose 1,6-bisphosphatase Msm_0615 38 COG1980 COG1980, Archaeal fructose 1,6-bisphosphatase Carbohydrate transport and metabolism 148643136 Common - putative monovalent cation/H+ antiporter subunit E Msm_1076 21 COG1863 MnhE, Multisubunit Na+/H+ antiporter, MnhE subunit Inorganic ion transport and metabolism 148642767 Nonpathogen - predicted subunit of tRNA methyltransferase Msm_0707 19 COG2117 COG2117, Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 148642120 Nonpathogen - predicted kinase (GHMP kinase family) Msm_0060 30 COG1829 COG1829, Predicted archaeal kinase (sugar kinase superfamily) General function prediction only 148642348 Common - hypothetical protein Msm_0288 25 COG1920 COG1920, Uncharacterized conserved protein Function unknown 148643299 Common - predicted DNA-binding protein Msm_1239 56 COG4277 COG4277, Predicted DNA-binding protein with the Helix-hairpin-helix motif General function prediction only 148643389 Common - predicted glycosyltransferase, GT2 family Msm_1329 144 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 148643719 Nonpathogen - hypothetical protein Msm_1659 1 None None None 148643495 Common - enolase Msm_1435 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 148642142 Common - heterodisulfide reductase, subunit A, HdrA Msm_0082 42 COG1148 HdrA, Heterodisulfide reductase, subunit A and related polyferredoxins Energy production and conversion 148642067 Nonpathogen - SAM-dependent methyltransferase Msm_0007 3 None None None 148643400 Common - S-adenosylmethionine synthetase Msm_1340 43 COG1812 MetK, Archaeal S-adenosylmethionine synthetase Amino acid transport and metabolism 148642149 Common - pyrroline-5-carboxylate reductase (NADP oxidoreductase, coenzyme F420-dependent), ProC Msm_0089 67 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 148643796 Common - permease, xanthine/uracil/vitamin C permease family Msm_1736 134 COG2252 COG2252, Permeases General function prediction only 148643564 Common - uroporphyrinogen III synthase, HemD Msm_1504 91 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 148642787 Common - S-adenosyl-L-homocysteine hydrolase Msm_0727 178 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 148643608 Common - phosphoribosylformylglycinamidine (FGAM) synthase, PurS Msm_1548 55 COG1828 PurS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component Nucleotide transport and metabolism 148642711 Common - O-linked GlcNAc transferase Msm_0651 156 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 148643263 Common - Zn-dependent protease, peptidase M48 family Msm_1203 118 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 148642350 Common - nitrate/sulfonate/bicarbonate ABC transporter, ATPase component, TauB Msm_0290 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 148642360 Common - peptide/nickel ABC transporter, solute-binding component Msm_0300 183 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 148643145 Common - aquaporin, MIP superfamily, AqpM Msm_1085 134 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 148643399 Common - hypothetical protein Msm_1339 15 COG1430 COG1430, Uncharacterized conserved protein Function unknown 148643582 Nonpathogen - hypothetical protein Msm_1522 1 None None None 148642099 Nonpathogen - hypothetical protein Msm_0039 1 None None None 148642339 Common - hypothetical protein Msm_0279 72 COG0432 COG0432, Uncharacterized conserved protein Function unknown 148643520 Common - energy-converting hydrogenase B, subunit K, EhbK Msm_1460 113 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 148642237 Nonpathogen - hypothetical protein Msm_0177 1 None None None 148642423 Nonpathogen - predicted RNA methylase Msm_0363 15 COG4076 COG4076, Predicted RNA methylase General function prediction only 148642876 Nonpathogen - hypothetical protein Msm_0816 30 COG1439 COG1439, Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module General function prediction only 148643816 Common - Smf protein Msm_1756 208 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 148642651 Nonpathogen - hypothetical protein Msm_0591 1 None None None 148643071 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit B Msm_1011 9 COG4062 MtrB, Tetrahydromethanopterin S-methyltransferase, subunit B Coenzyme metabolism 148643510 Common - predicted oxidoreductase, aldo/keto reductase family Msm_1450 188 COG1453 COG1453, Predicted oxidoreductases of the aldo/keto reductase family General function prediction only 148643092 Common - transcriptional regulator, Lrp family Msm_1032 131 COG1522 Lrp, Transcriptional regulators Transcription 148642575 Nonpathogen - methanol:cobalamin methyltransferase. MtaB Msm_0515 6 None None None 148643026 Common - predicted 26S protease regulatory subunit (ATP-dependent), AAA+ family ATPase Msm_0966 249 COG1223 COG1223, Predicted ATPase (AAA+ superfamily) General function prediction only 148642752 Nonpathogen - hypothetical protein Msm_0692 5 None None None 148643424 Common - imidazoleglycerol-phosphate synthase, HisF Msm_1364 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 148643127 Nonpathogen - energy-converting hydrogenase B, subunit J, EhbJ Msm_1067 4 None None None 148642597 Nonpathogen - TPR-repeat protein Msm_0537 1 None None None 148642403 Common - GMP synthase subunit A Msm_0343 241 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 148643749 Nonpathogen - putative collagen-like protein B Msm_1689 1 None None None 148642088 Common - SAM-dependent methyltransferase Msm_0028 48 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 148643333 Common - cobalt precorrin-3B C17-methyltransferase, CbiH Msm_1273 119 COG1010 CobJ, Precorrin-3B methylase Coenzyme metabolism 148643563 Common - glycosyltransferase, GT2 family Msm_1503 151 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 148642867 Common - polar amino acid ABC transporter, substrate-binding component Msm_0807 171 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 148642218 Common - type I restriction-modification system methylase, subunit S Msm_0158 50 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 148642973 Nonpathogen - hypothetical protein Msm_0913 1 None None None 148643390 Common - predicted glycosyltransferase, GT2 family Msm_1330 174 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 148642586 Nonpathogen - hypothetical protein Msm_0526 4 None None None 148643825 Common - hypothetical protein Msm_1765 4 None None None 148642746 Common - acetolactate synthase (TPP-requiring), large subunit, IlvB Msm_0686 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 148642744 Nonpathogen - hypothetical protein Msm_0684 1 None None None 148642861 Nonpathogen - diphthine synthase Msm_0801 38 COG1798 DPH5, Diphthamide biosynthesis methyltransferase Translation, ribosomal structure and biogenesis 148642246 Common - hypothetical protein Msm_0186 132 COG1739 COG1739, Uncharacterized conserved protein Function unknown 148642891 Common - dihydrodipicolinate synthase Msm_0831 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 148642558 Nonpathogen - hypothetical protein Msm_0498 1 None None None 148643739 Nonpathogen - hypothetical protein Msm_1679 1 None None None 148642854 Nonpathogen - hypothetical protein Msm_0794 5 COG4009 COG4009, Uncharacterized protein conserved in archaea Function unknown 148643098 Common - predicted metal-dependent RNase Msm_1038 148 COG1782 COG1782, Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain General function prediction only 148642672 Common - putative translation factor, Sua5/YciO/YrdC/YwlC family Msm_0612 241 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 148643165 Common - NCAIR mutase related protein, PurE Msm_1105 78 COG1691 COG1691, NCAIR mutase (PurE)-related proteins General function prediction only 148642315 Nonpathogen - putative transcription regulator (winged helix DNA-binding domain) Msm_0255 3 None None None 148642331 Common - cysteine synthase, CysK Msm_0271 223 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 148643216 Common - tRNA pseudouridine synthase D, TruD Msm_1156 92 COG0585 COG0585, Uncharacterized conserved protein Function unknown 148642890 Common - dihydrodipicolinate reductase Msm_0830 216 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 148642981 Nonpathogen - predicted surface protein Msm_0921 1 None None None 148642759 Common - Na+-dependent transporter, SNF family Msm_0699 89 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 148642513 Nonpathogen - hypothetical protein Msm_0453 32 COG1395 COG1395, Predicted transcriptional regulator Transcription 148642839 Common - predicted Zn-dependent hydrolase, metallo-beta-lactamase superfamily Msm_0779 101 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 148642843 Common - tungsten formylmethanofuran dehydrogenase, subunit F, FwdF Msm_0783 176 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 148643646 Common - adhesin-like protein Msm_1586 47 None None None 148643678 Common - cobalt transport protein CbiM Msm_1618 79 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 148643556 Nonpathogen - hypothetical protein Msm_1496 2 None None None 148642965 Nonpathogen - methyl-coenzyme M reductase, beta subunit, McrB Msm_0905 14 COG4054 McrB, Methyl coenzyme M reductase, beta subunit Coenzyme metabolism 148642365 Common - hypothetical protein Msm_0305 28 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 148643710 Nonpathogen - hypothetical protein Msm_1650 1 None None None 148642562 Common - ATP-dependent helicase, Lhr-like protein Msm_0502 235 COG1201 Lhr, Lhr-like helicases General function prediction only 148642948 Common - glutamate dehydrogenase Msm_0888 164 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 148643116 Common - 6-pyruvoyl-tetrahydropterin synthase Msm_1056 50 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 148643631 Nonpathogen - hypothetical protein Msm_1571 1 None None None 148642664 Common - predicted aspartate/glutamate/uridylate kinase Msm_0604 21 COG2054 COG2054, Uncharacterized archaeal kinase related to aspartokinases, uridylate kinases General function prediction only 148642897 Common cbiD cobalt-precorrin-6A synthase Msm_0837 92 COG1903 CbiD, Cobalamin biosynthesis protein CbiD Coenzyme metabolism 148643757 Nonpathogen - hypothetical protein Msm_1697 1 None None None 148642706 Common - hypothetical protein Msm_0646 84 COG1738 COG1738, Uncharacterized conserved protein Function unknown 148643287 Common - phosphoribosylamine-glycine ligase, PurD Msm_1227 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 148643831 Common - DNA helicase, UvrD/REP helicase family Msm_1771 230 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 148642502 Nonpathogen - hypothetical protein Msm_0442 1 None None None 148643746 Nonpathogen - hypothetical protein Msm_1686 1 None None None 148642462 Common dcd deoxycytidine triphosphate deaminase Msm_0402 170 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 148642626 Common - phosphate ABC transporter, permease component, PstA Msm_0566 228 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 148643292 Common - signal peptidase I Msm_1232 22 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 148643044 Common - sortase (surface protein transpeptidase), SrtA Msm_0984 8 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 148642469 Nonpathogen - C4-type Zinc-finger protein Msm_0409 29 COG1779 COG1779, C4-type Zn-finger protein General function prediction only 148642343 Nonpathogen - hypothetical protein Msm_0283 1 None None None 148642958 Common - elongation factor 1-alpha Msm_0898 249 COG5256 TEF1, Translation elongation factor EF-1alpha (GTPase) Translation, ribosomal structure and biogenesis 148643838 Nonpathogen - hypothetical protein Msm_1778 2 None None None 148643463 Common - formate/nitrite transporter, FdhC Msm_1403 94 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 148643607 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase Msm_1547 229 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 148642638 Nonpathogen - hypothetical protein Msm_0578 7 COG4016 COG4016, Uncharacterized protein conserved in archaea Function unknown 148642832 Common - predicted permease, major facilitator superfamily Msm_0772 12 None None None 148643282 Common - ketol-acid reductoisomerase Msm_1222 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 148643259 Nonpathogen - hypothetical protein Msm_1199 1 None None None 148642228 Nonpathogen - conserved hypothetical protein predicted to be involved in DNA repair Msm_0168 Msm_0168 14 COG1857 COG1857, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 148642954 Nonpathogen - hypothetical protein Msm_0894 10 COG1255 COG1255, Uncharacterized protein conserved in archaea Function unknown 148643697 Nonpathogen - hypothetical protein Msm_1637 1 None None None 148643283 Common - carbonic anhydrase Msm_1223 49 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 148643384 Common - glycosyltransferase, GT2 family Msm_1324 155 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 148643597 Common - predicted acylneuraminate cytidylyltransferase, NeuS Msm_1537 28 COG1861 SpsF, Spore coat polysaccharide biosynthesis protein F, CMP-KDO synthetase homolog Cell envelope biogenesis, outer membrane 148642540 Common - YcaO-like protein Msm_0480 57 COG1944 COG1944, Uncharacterized conserved protein Function unknown 148642191 Common - molybdenum-binding protein, MopI Msm_0131 75 COG3585 MopI, Molybdopterin-binding protein Coenzyme metabolism 148643007 Common - predicted zinc metalloprotease, modulator of DNA gyrase Msm_0947 158 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 148643313 Common gatA aspartyl/glutamyl-tRNA amidotransferase subunit A Msm_1253 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 148643772 Common - predicted ferritin Msm_1712 85 COG1528 Ftn, Ferritin-like protein Inorganic ion transport and metabolism 148642978 Common pgk phosphoglycerate kinase Msm_0918 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 148643656 Nonpathogen - putative transposase Msm_1596 4 None None None 148643194 Nonpathogen rps27e 30S ribosomal protein S27e Msm_1134 33 COG2051 RPS27A, Ribosomal protein S27E Translation, ribosomal structure and biogenesis 148643500 Common - predicted kinase Msm_1440 83 COG1608 COG1608, Predicted archaeal kinase General function prediction only 148642151 Nonpathogen - 2,3-diphosphoglycerate synthase (putative GTPase) Msm_0091 7 COG2403 COG2403, Predicted GTPase General function prediction only 148642911 Common - predicted transcriptional regulator Msm_0851 24 COG1548 COG1548, Predicted transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 148643690 Nonpathogen rpl37ae 50S ribosomal protein L37Ae Msm_1630 34 COG1997 RPL43A, Ribosomal protein L37AE/L43A Translation, ribosomal structure and biogenesis 148642390 Common - acetyl-CoA synthetase, AMP-forming-related, Acs Msm_0330 221 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 148642432 Common - phycobiliprotein (PBS) lyase (HEAT repeat) Msm_0372 42 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 148643466 Common moaA molybdenum cofactor biosynthesis protein A Msm_1406 211 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 148643509 Common - putative O-linked GlcNAc transferase Msm_1449 8 COG2976 COG2976, Uncharacterized protein conserved in bacteria Function unknown 148643301 Common - chromosome partitioning ATPase Msm_1241 231 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 148642160 Nonpathogen - hypothetical protein Msm_0100 3 None None None 148643486 Common rps4p 30S ribosomal protein S4 Msm_1426 132 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 148643716 Nonpathogen - hypothetical protein Msm_1656 1 None None None 148642828 Nonpathogen - hypothetical protein Msm_0768 1 None None None 148642456 Nonpathogen - putative transposase Msm_0396 3 None None None 148642486 Common - demethylmenaquinone methyltransferase Msm_0426 100 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 148642397 Nonpathogen - putative adhesin-like protein Msm_0337 2 None None None 148642494 Common - V-type ATP synthase subunit B Msm_0434 247 COG1156 NtpB, Archaeal/vacuolar-type H+-ATPase subunit B Energy production and conversion 148642918 Common - phosphoribosylformimino-5-aminoimidazole carboxamide ribotide (ProFAR) isomerase, HisA Msm_0858 215 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 148642299 Common - hypothetical protein Msm_0239 15 None None None 148643272 Common - hypothetical protein Msm_1212 13 None None None 148643315 Nonpathogen - hypothetical protein Msm_1255 1 None None None 148643378 Nonpathogen - hypothetical protein Msm_1318 2 None None None 148643833 Nonpathogen - hypothetical protein Msm_1773 4 COG1499 NMD3, NMD protein affecting ribosome stability and mRNA decay Translation, ribosomal structure and biogenesis 148642440 Nonpathogen - hypothetical protein Msm_0380 1 None None None 148643660 Common - putative acetyltransferase, trimeric LpxA-like family Msm_1600 2 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 148642115 Common - 3-dehydroquinate synthase Msm_0055 28 COG1465 COG1465, Predicted alternative 3-dehydroquinate synthase Amino acid transport and metabolism 148643324 Nonpathogen - cell division control protein 6, Cdc6 Msm_1264 31 COG1474 CDC6, Cdc6-related protein, AAA superfamily ATPase DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones 148643702 Nonpathogen - hypothetical protein Msm_1642 1 None None None 148642487 Nonpathogen - DNA primase Msm_0427 34 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 148642176 Common - MobA-related protein Msm_0116 27 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 148642646 Common - cobalt ABC transporter, ATPase component, CbiO Msm_0586 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 148642221 Nonpathogen - hypothetical protein Msm_0161 1 None None None 148643614 Nonpathogen - putative adhesin-like protein Msm_1554 2 None None None 148643078 Nonpathogen - methyl-coenzyme M reductase, D subunit, McrD Msm_1018 14 COG4055 McrD, Methyl coenzyme M reductase, subunit D Coenzyme metabolism 148643791 Common - short chain dehydrogenase/reductase Msm_1731 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 148642158 Nonpathogen - hypothetical protein Msm_0098 1 None None None 148642288 Common - succinyl-CoA synthetase subunit alpha Msm_0228 213 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 148643025 Common - 3-hydroxybutyryl-CoA dehydrogenase Msm_0965 156 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 148642264 Nonpathogen - 50S ribosomal protein L24e Msm_0204 32 COG2075 RPL24A, Ribosomal protein L24E Translation, ribosomal structure and biogenesis 148642708 Common - phosphomannomutase, ManB Msm_0648 243 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 148643418 Nonpathogen - diphthamide synthase, subunit DPH2 Msm_1358 34 COG1736 DPH2, Diphthamide synthase subunit DPH2 Translation, ribosomal structure and biogenesis 148642447 Common - coenzyme F390 synthetase, PaaK Msm_0387 118 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 148643536 Common - delta-aminolevulinic acid dehydratase Msm_1476 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 148642328 Common - cysteinyl-tRNA synthetase, CysS Msm_0268 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 148642096 Nonpathogen - hypothetical protein Msm_0036 1 None None None 148642852 Common - predicted calcineurin-like phosphoesterase Msm_0792 37 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 148643768 Nonpathogen - hypothetical protein Msm_1708 1 None None None 148642939 Common - Poly(P)/ATP NAD kinase, inositol monophosphatase family, PpnK Msm_0879 243 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 148643638 Nonpathogen - hypothetical protein Msm_1578 1 None None None 148643722 Nonpathogen - hypothetical protein Msm_1662 1 None None None 148643172 Common - adhesin-like protein Msm_1112 86 None None None 148643665 Nonpathogen - hypothetical protein Msm_1605 1 None None None 148643160 Nonpathogen - hypothetical protein Msm_1100 2 None None None 148643366 Common - adhesin-like protein Msm_1306 63 COG1520 COG1520, FOG: WD40-like repeat Function unknown 148642280 Common - chaperonin (TCP-1/cpn60 family), alpha subunit Msm_0220 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 148643069 Nonpathogen mtrF tetrahydromethanopterin S-methyltransferase subunit F Msm_1009 2 COG4218 MtrF, Tetrahydromethanopterin S-methyltransferase, subunit F Coenzyme metabolism 148642718 Nonpathogen - hypothetical protein Msm_0658 1 None None None 148643340 Common - sirohydrochlorin cobaltochelatase Msm_1280 34 COG2138 COG2138, Uncharacterized conserved protein Function unknown 148643580 Nonpathogen - IS element (transposase remnant) Msm_1520 1 None None None 148642276 Common - tryptophanyl-tRNA synthetase Msm_0216 102 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 148642376 Nonpathogen - hypothetical protein Msm_0316 1 None None None 148642923 Common - pyridoxamine-phosphate oxidase (FMN-binding) Msm_0863 13 COG5015 COG5015, Uncharacterized conserved protein Function unknown 148643228 Common - putative adhesin-like protein Msm_1168 5 None None None 148642798 Common - preprotein translocase subunit SecY Msm_0738 196 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 148642971 Common - DNA-directed RNA polymerase subunit beta'' Msm_0911 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 148642944 Nonpathogen - adhesin-like protein Msm_0884 6 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 148643756 Nonpathogen - hypothetical protein Msm_1696 2 COG4640 COG4640, Predicted membrane protein Function unknown 148642754 Nonpathogen - hypothetical protein Msm_0694 1 None None None 148643801 Common - hypothetical protein Msm_1741 23 COG3586 COG3586, Uncharacterized conserved protein Function unknown 148642189 Common - nicotinamide mononucleotide adenylyltransferase, NadR Msm_0129 51 COG1056 NadR, Nicotinamide mononucleotide adenylyltransferase Coenzyme metabolism 148643183 Common - coenzyme F420-reducing hydrogenase, delta subunit, FrhD Msm_1123 57 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 148643104 Common - dihydroorotate dehydrogenase 1B Msm_1044 224 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 148643571 Nonpathogen - hypothetical protein Msm_1511 1 None None None 148642801 Common rps5p 30S ribosomal protein S5P Msm_0741 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 148642074 Nonpathogen - putative heat shock related protein Msm_0014 1 None None None 148643686 Common - predicted fumarate reductase Msm_1626 99 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 148642476 Common - Mg-dependent DNase, TatD-related Msm_0416 236 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 148643085 Nonpathogen - hypothetical protein Msm_1025 3 None None None 148642203 Nonpathogen - hypothetical protein Msm_0143 3 None None None 148643440 Common - NADP-dependent alcohol dehydrogenase Msm_1380 112 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 148643782 Common - nitroreductase Msm_1722 117 COG0778 NfnB, Nitroreductase Energy production and conversion 148643622 Common - acetyl-CoA acetyltransferase Msm_1562 178 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 148643457 Common - adhesin-like protein Msm_1397 19 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 148642416 Nonpathogen - hypothetical protein Msm_0356 11 COG1844 COG1844, Uncharacterized protein conserved in archaea Function unknown 148642616 Common - dihydropteroate synthase Msm_0556 36 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 148642885 Common - adenosylcobinamide amidohydrolase, CbiZ Msm_0825 31 COG1865 COG1865, Uncharacterized conserved protein Function unknown 148642576 Common - corrinoid protein (methionine synthase-related), MtaC Msm_0516 164 COG5012 COG5012, Predicted cobalamin binding protein General function prediction only 148643734 Nonpathogen - hypothetical protein Msm_1674 1 None None None 148642645 Common - cobalt ABC transporter, permease component, CbiQ Msm_0585 91 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 148642294 Common - ammonium transporter Msm_0234 202 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 148643277 Nonpathogen - type II restriction endonuclease Msm_1217 3 COG1715 Mrr, Restriction endonuclease Defense mechanisms 148643432 Common - diaminopimelate epimerase, DapF Msm_1372 203 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 148643599 Common - sialic acid synthase, NeuB Msm_1539 78 COG2089 SpsE, Sialic acid synthase Cell envelope biogenesis, outer membrane 148642697 Common - dihydrolipoamide dehydrogenase Msm_0637 242 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 148642791 Common - putative DNA helicase II, UvrD Msm_0731 195 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 148643034 Common - LPPG:FO 2-phospho-L-lactate transferase, CofD Msm_0974 57 COG0391 COG0391, Uncharacterized conserved protein Function unknown 148643527 Nonpathogen - hypothetical protein Msm_1467 1 None None None 148643559 Nonpathogen - predicted transcriptional regulator Msm_1499 22 COG1497 COG1497, Predicted transcriptional regulator Transcription 148643207 Nonpathogen - hypothetical protein Msm_1147 1 None None None 148642471 Common - adhesin-like protein Msm_0411 48 None None None 148642687 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit H Msm_0627 17 COG1962 MtrH, Tetrahydromethanopterin S-methyltransferase, subunit H Coenzyme metabolism 148642449 Nonpathogen - hypothetical protein Msm_0389 1 None None None 148642817 Common rpl22p 50S ribosomal protein L22P Msm_0757 61 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 148643049 Nonpathogen rpl10e 50S ribosomal protein L10e Msm_0989 35 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 148642703 Nonpathogen - hypothetical protein Msm_0643 14 COG4022 COG4022, Uncharacterized protein conserved in archaea Function unknown 148642628 Common - phosphate ABC transporter, phosphate-binding component, PstS Msm_0568 177 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 148643795 Common - adhesin-like protein Msm_1735 43 COG4870 COG4870, Cysteine protease Posttranslational modification, protein turnover, chaperones 148643248 Common - adhesin-like protein Msm_1188 156 None None None 148643311 Common - predicted sugar phosphate isomerase/epimerase, AP endonuclease family 2 Msm_1251 34 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 148642500 Common - V-type ATP synthase subunit I Msm_0440 44 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 148642265 Nonpathogen rps28e 30S ribosomal protein S28e Msm_0205 33 COG2053 RPS28A, Ribosomal protein S28E/S33 Translation, ribosomal structure and biogenesis 148642887 Common - predicted metal-dependent hydrolase, cyclase family Msm_0827 84 COG1878 COG1878, Predicted metal-dependent hydrolase General function prediction only 148643605 Common - glycosyltransferase, GT2 family Msm_1545 178 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 148643524 Nonpathogen - FlpE-related protein Msm_1464 3 None None None 148643357 Common - glycosyltransferase, GT2 family Msm_1297 96 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 148643330 Common - fuculose-1-phosphate aldolase, class II aldolase/adducin family Msm_1270 156 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 148642851 Nonpathogen - 2-phosphoglycerate kinase Msm_0791 14 COG2074 COG2074, 2-phosphoglycerate kinase Carbohydrate transport and metabolism 148643143 Nonpathogen - hypothetical protein Msm_1083 3 COG1316 LytR, Transcriptional regulator Transcription 148643115 Common - coenzyme PQQ synthesis protein, SAM family Msm_1055 163 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 148643592 Common - Na+-dependent transporter, SNF family Msm_1532 88 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 148642845 Common - phosphopantetheine adenylyltransferase Msm_0785 28 COG1019 COG1019, Predicted nucleotidyltransferase General function prediction only 148642760 Common - putative poly-gamma-glutamate synthesis protein, PgsA Msm_0700 81 COG2843 PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) Cell envelope biogenesis, outer membrane 148642899 Common - ATP-dependent helicase Msm_0839 106 COG1204 COG1204, Superfamily II helicase General function prediction only 148643130 Nonpathogen - energy-converting hydrogenase B, subunit G, EhbG Msm_1070 1 None None None 148643280 Nonpathogen - small nucleolar ribonucleoprotein, Sm-like family Msm_1220 2 None None None 148643854 Nonpathogen - predicted tubulin-like protein Msm_1794 6 None None None 148643827 Nonpathogen - hypothetical protein Msm_1767 1 COG4640 COG4640, Predicted membrane protein Function unknown 148642468 Nonpathogen - hypothetical protein Msm_0408 14 COG2074 COG2074, 2-phosphoglycerate kinase Carbohydrate transport and metabolism 148642361 Common - peptide/nickel ABC transporter, permease component, DppB Msm_0301 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 148643774 Common - coenzyme F390 synthetase Msm_1714 125 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 148643392 Nonpathogen - replication factor A Msm_1332 20 COG1599 RFA1, Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins DNA replication, recombination, and repair 148642234 Common - O-acetylhomoserine sulfhydrylase (PLP-dependent), MET17 Msm_0174 206 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 148643692 Nonpathogen - predicted brix-domain ribosomal biogenesis protein Msm_1632 17 COG2136 IMP4, Predicted exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component, contains IMP4 domain Translation, ribosomal structure and biogenesis / RNA processing and modification 148642379 Common - NADH dehydrogenase I, subunit N related Msm_0319 19 COG4078 COG4078, Predicted membrane protein Function unknown 148642453 Common - succinate dehydrogenase/fumarate reductase iron-sulfur subunit Msm_0393 223 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 148643059 Common - methyl viologen-reducing hydrogenase, alpha subunit, MvhA Msm_0999 101 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 148643318 Common sdhA succinate dehydrogenase flavoprotein subunit Msm_1258 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 148643125 Common - ferredoxin Msm_1065 21 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 148642666 Nonpathogen - hypothetical protein Msm_0606 1 None None None 148642105 Common - nucleotide-binding protein (putative ATPase involved in chromosome partitioning) Msm_0045 235 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 148642357 Nonpathogen - predicted exosome subunit Msm_0297 13 COG1325 COG1325, Predicted exosome subunit Translation, ribosomal structure and biogenesis 148643182 Common - coenzyme F420-reducing hydrogenase, gamma subunit, FrhG Msm_1122 53 COG1941 FrhG, Coenzyme F420-reducing hydrogenase, gamma subunit Energy production and conversion 148643474 Common - tungsten formylmethanofuran dehydrogenase, subunit C, FwdC Msm_1414 41 COG2218 FwdC, Formylmethanofuran dehydrogenase subunit C Energy production and conversion 148642244 Nonpathogen - creatinine amidohydrolase Msm_0184 12 COG1402 COG1402, Uncharacterized protein, putative amidase General function prediction only 148643394 Common - predicted permease Msm_1334 142 COG0679 COG0679, Predicted permeases General function prediction only 148642880 Common - molybdenum cofactor biosynthesis protein, MoaB Msm_0820 190 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 148642568 Common - cell division protein J (23S rRNA methylase), FtsJ Msm_0508 139 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 148643434 Common ksgA dimethyladenosine transferase Msm_1374 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 148643501 Common - isopentenyl pyrophosphate isomerase Msm_1441 81 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 148642962 Nonpathogen - methyl-coenzyme M reductase, alpha subunit, McrA Msm_0902 14 COG4058 McrA, Methyl coenzyme M reductase, alpha subunit Coenzyme metabolism 148643715 Nonpathogen - hypothetical protein Msm_1655 1 None None None 148642609 Common - cytochrome C-type biogenesis protein, DsbD Msm_0549 12 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 148642892 Common - aspartate kinase Msm_0832 236 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 148642983 Common - multimeric flavodoxin Msm_0923 45 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 148643293 Common - glutamate-1-semialdehyde aminotransferase Msm_1233 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 148643623 Nonpathogen - hypothetical protein Msm_1563 1 None None None 148642604 Nonpathogen - predicted Fe-S oxidoreductase Msm_0544 28 COG1244 COG1244, Predicted Fe-S oxidoreductase General function prediction only 148642804 Nonpathogen rpl32e 50S ribosomal protein L32e Msm_0744 34 COG1717 RPL32, Ribosomal protein L32E Translation, ribosomal structure and biogenesis 148642529 Common - hypothetical protein Msm_0469 3 COG3548 COG3548, Predicted integral membrane protein Function unknown 148643056 Common - adhesin-like protein Msm_0996 26 None None None 148643339 Common - predicted nucleic-acid-binding protein containing a Zn-ribbon Msm_1279 65 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 148643161 Common gatB aspartyl/glutamyl-tRNA amidotransferase subunit B Msm_1101 214 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 148642519 Nonpathogen - hypothetical protein Msm_0459 1 None None None 148642733 Common - hypothetical protein Msm_0673 14 COG2364 COG2364, Predicted membrane protein Function unknown 148642219 Nonpathogen - adhesin-like protein Msm_0159 2 None None None 148643210 Common - predicted transcriptional regulator Msm_1150 61 COG1476 COG1476, Predicted transcriptional regulators Transcription 148643086 Common - hemolysin-related protein, transporter-associated family, TlyC Msm_1026 219 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 148642212 Common - Na+-driven multidrug efflux pump (MATE family), NorM Msm_0152 179 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 148642326 Common - adhesin-like protein Msm_0266 54 None None None 148643070 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit A Msm_1010 17 COG4063 MtrA, Tetrahydromethanopterin S-methyltransferase, subunit A Coenzyme metabolism 148643659 Common - SAM-dependent methyltransferase Msm_1599 14 COG4627 COG4627, Uncharacterized protein conserved in bacteria Function unknown 148642421 Common - carbamoyl-phosphate synthase, large subunit, CarB Msm_0361 166 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 148642951 Nonpathogen - peptide chain release factor 1 Msm_0891 35 COG1503 eRF1, Peptide chain release factor 1 (eRF1) Translation, ribosomal structure and biogenesis 148642770 Common - RNA-binding protein, CRS1/YhbY family Msm_0710 18 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 148643387 Common - predicted CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase Msm_1327 34 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 148643257 Common - predicted ATPase, AAA+ superfamily Msm_1197 32 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 148642184 Common - geranylgeranylglyceryl phosphate synthase-like protein Msm_0124 37 COG1646 COG1646, Predicted phosphate-binding enzymes, TIM-barrel fold General function prediction only 148643551 Nonpathogen - formylmethanofuran dehydrogenase subunit E, metal-binding Msm_1491 8 COG5643 COG5643, Protein containing a metal-binding domain shared with formylmethanofuran dehydrogenase subunit E General function prediction only 148643090 Common - predicted pyridoxal phosphate-dependent enzyme Msm_1030 197 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 148643416 Nonpathogen - DNA-directed RNA polymerase, subunit L, RpoL Msm_1356 15 COG1761 RPB11, DNA-directed RNA polymerase, subunit L Transcription 148642863 Common - predicted metal-dependent membrane protease, CAAX amino terminal protease family Msm_0803 16 None None None 148642728 Common - hypothetical protein Msm_0668 22 COG1371 COG1371, Uncharacterized conserved protein Function unknown 148642542 Common - ATP-utilizing enzyme, PP-loop superfamily Msm_0482 67 COG1606 COG1606, ATP-utilizing enzymes of the PP-loop superfamily General function prediction only 148643168 Common - molecular chaperone GrpE Msm_1108 227 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 148642112 Common - adhesin-like protein Msm_0052 48 COG1103 COG1103, Archaea-specific pyridoxal phosphate-dependent enzymes General function prediction only 148643706 Nonpathogen - putative ATPase (AAA+ superfamily) Msm_1646 3 COG1474 CDC6, Cdc6-related protein, AAA superfamily ATPase DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones 148643441 Common - putative NADP-dependent alcohol dehydrogenase Msm_1381 7 None None None 148642777 Common - DNA topoisomerase I, TopA Msm_0717 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 148642812 Common rps17p 30S ribosomal protein S17P Msm_0752 36 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 148643139 Nonpathogen - predicted membrane-bound metal-dependent hydrolase, NCS2 family Msm_1079 5 None None None 148643585 Common - hypothetical protein Msm_1525 3 None None None 148642552 Common - ribonuclease Z (zinc-dependent), beta-lactamase superfamily, ElaC Msm_0492 132 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 148642144 Nonpathogen - heterodisulfide reductase, subunit C, HdrC Msm_0084 27 COG1150 HdrC, Heterodisulfide reductase, subunit C Energy production and conversion 148642610 Common - protein disulfide-isomerase, thioredoxin-related Msm_0550 31 COG2143 COG2143, Thioredoxin-related protein Posttranslational modification, protein turnover, chaperones 148643309 Common - multidrug ABC transporter, ATPase component Msm_1249 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 148642303 Nonpathogen - exosome complex RNA-binding protein Rrp4 Msm_0243 24 COG1097 RRP4, RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain) Translation, ribosomal structure and biogenesis 148642788 Common - predicted oxidoreductase, aldo/keto reductase family Msm_0728 181 COG1453 COG1453, Predicted oxidoreductases of the aldo/keto reductase family General function prediction only 148642122 Common - flavodoxin Msm_0062 28 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 148642753 Common - ATPase involved in DNA repair, SbcC Msm_0693 58 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 148643517 Nonpathogen - hypothetical protein Msm_1457 3 None None None 148642694 Common - predicted metal-sulfur cluster biosynthetic enzyme Msm_0634 14 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 148642538 Nonpathogen - hypothetical protein Msm_0478 1 None None None 148643566 Nonpathogen - hypothetical protein Msm_1506 1 None None None 148643837 Nonpathogen - putative transcription regulator Msm_1777 2 COG4742 COG4742, Predicted transcriptional regulator Transcription 148642448 Common - amino acid regulator Msm_0388 38 COG4747 COG4747, ACT domain-containing protein General function prediction only 148643345 Common - hypothetical protein Msm_1285 5 None None None 148643350 Common - glycosyltransferase Msm_1290 129 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 148642769 Nonpathogen - 30S ribosomal protein S19e Msm_0709 34 COG2238 RPS19A, Ribosomal protein S19E (S16A) Translation, ribosomal structure and biogenesis 148643465 Nonpathogen - formate dehydrogenase, beta subunit, FdhB Msm_1405 30 COG1035 FrhB, Coenzyme F420-reducing hydrogenase, beta subunit Energy production and conversion 148643673 Common - predicted UDP-glucose/GDP-mannose dehydrogenase Msm_1613 157 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 148642781 Common - adenylate cyclase, class 2 Msm_0721 35 COG1437 CyaB, Adenylate cyclase, class 2 (thermophilic) Nucleotide transport and metabolism 148642352 Common - predicted metal-dependent membrane protease Msm_0292 13 None None None 148642509 Common - 2-methylcitrate dehydratase, MmgE/PrpD family Msm_0449 59 COG2079 PrpD, Uncharacterized protein involved in propionate catabolism General function prediction only 148642138 Common - dolichol kinase (cytidylyltransferase family) Msm_0078 22 COG0170 SEC59, Dolichol kinase Lipid metabolism 148643364 Common - dTDP-4-dehydrorhamnose reductase, RfbD Msm_1304 178 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 148643633 Common - N-acetyltransferase, GNAT family Msm_1573 91 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 148643558 Common - helicase Msm_1498 233 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 148642946 Nonpathogen - hypothetical protein Msm_0886 1 None None None 148642227 Nonpathogen - conserved hypothetical protein predicted to be involved in DNA repair Msm_0167 Msm_0167 7 COG1688 COG1688, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 148643155 Common - Trk-type potassium transport system, membrane component, TrkH Msm_1095 121 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 148642201 Nonpathogen - dephospho-CoA kinase, CoaE Msm_0141 37 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 148643371 Common - glycosyltransferase, GT2 family Msm_1311 107 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 148643848 Common - O-linked GlcNAc transferase Msm_1788 46 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 148643841 Nonpathogen - hypothetical protein Msm_1781 4 COG4640 COG4640, Predicted membrane protein Function unknown 148642731 Nonpathogen cdc6 cell division control protein 6 Msm_0671 31 COG1474 CDC6, Cdc6-related protein, AAA superfamily ATPase DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones 148642850 Common - CBS-domain-containing protein Msm_0790 179 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 148642643 Common - cobalt transport protein CbiM Msm_0583 79 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 148642077 Nonpathogen - hypothetical protein Msm_0017 1 None None None 148642820 Common - ribosomal protein L23p Msm_0760 65 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 148643322 Common - flavodoxin (protoporphyrinogen oxidase) Msm_1262 9 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 148643151 Common - sugar kinase, YjeF-related protein family Msm_1091 219 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 148642755 Common - DNA repair helicase Msm_0695 140 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 148642906 Nonpathogen - uncharacterized Zn-finger protein Msm_0846 21 COG1326 COG1326, Uncharacterized archaeal Zn-finger protein General function prediction only 148643327 Common - cobalamin biosynthesis protein G, CbiG Msm_1267 99 COG2073 CbiG, Cobalamin biosynthesis protein CbiG Coenzyme metabolism 148642167 Common - hydrogenase expression/formation protein, HypB Msm_0107 135 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 148643732 Nonpathogen - bacteriophage capsid portal protein Msm_1672 2 COG5518 COG5518, Bacteriophage capsid portal protein General function prediction only 148643460 Common - putative antimicrobial peptide ABC transporter, permease component Msm_1400 2 None None None 148642254 Nonpathogen rps24e 30S ribosomal protein S24e Msm_0194 22 COG2004 RPS24A, Ribosomal protein S24E Translation, ribosomal structure and biogenesis 148643594 Common - adhesin-like protein Msm_1534 62 None None None 148643543 Common - multidrug ABC transporter, ATPase component Msm_1483 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 148642976 Common - hydroxyethylthiazole kinase, ThiM Msm_0916 79 COG2145 ThiM, Hydroxyethylthiazole kinase, sugar kinase family Coenzyme metabolism 148643654 Common - glycosyltransferase/CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase, GT2 family Msm_1594 214 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 148643577 Common - ornithine cyclodeaminase Msm_1517 67 COG2423 COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog Amino acid transport and metabolism 148643174 Common - adhesin-like protein Msm_1114 41 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 148642986 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit beta Msm_0926 110 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 148642991 Common - hypothetical protein Msm_0931 32 COG1415 COG1415, Uncharacterized conserved protein Function unknown 148643355 Nonpathogen - predicted DNA-binding protein Msm_1295 19 COG1571 COG1571, Predicted DNA-binding protein containing a Zn-ribbon domain General function prediction only 148642792 Common - H/ACA RNA-protein complex component Cbf5p Msm_0732 243 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 148643106 Nonpathogen - pre-mRNA splicing ribonucleoprotein PRP31 Msm_1046 34 COG1498 SIK1, Protein implicated in ribosomal biogenesis, Nop56p homolog Translation, ribosomal structure and biogenesis 148642278 Common - iron dependent transcriptional regulator (Fe2+-binding) Msm_0218 113 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 148643016 Common - DNA topoisomerase VI subunit A Msm_0956 34 COG1697 COG1697, DNA topoisomerase VI, subunit A DNA replication, recombination, and repair 148642716 Common - phosphomannomutase, ManB Msm_0656 243 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 148643675 Common - deoxyhypusine synthase, Dys Msm_1615 61 COG1899 DYS1, Deoxyhypusine synthase Posttranslational modification, protein turnover, chaperones 148642374 Nonpathogen - hypothetical protein Msm_0314 4 COG4084 COG4084, Uncharacterized protein conserved in archaea Function unknown 148642480 Common - predicted permease Msm_0420 54 COG0730 COG0730, Predicted permeases General function prediction only 148643279 Nonpathogen - hypothetical protein Msm_1219 1 None None None 148642595 Nonpathogen - hypothetical protein Msm_0535 1 None None None 148642186 Nonpathogen - hypothetical protein Msm_0126 25 COG2042 COG2042, Uncharacterized conserved protein Function unknown 148643751 Nonpathogen - putative PeiW-related protein (phage psiM100) Msm_1691 3 None None None 148642934 Common - adenine deaminase, AdeC Msm_0874 69 COG1001 AdeC, Adenine deaminase Nucleotide transport and metabolism 148642152 Nonpathogen - putative adhesin-like protein Msm_0092 2 None None None 148643223 Nonpathogen - hypothetical protein Msm_1163 1 None None None 148642833 Common - multidrug ABC transporter, ATPase component Msm_0773 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 148642693 Nonpathogen - archaeosine tRNA-ribosyltransferase Msm_0633 24 COG1549 COG1549, Queuine tRNA-ribosyltransferases, contain PUA domain Translation, ribosomal structure and biogenesis 148642106 Common - NADH oxidase Msm_0046 245 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 148643032 Common - tRNA-dihydrouridine synthase Msm_0972 52 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 148643704 Nonpathogen - hypothetical protein Msm_1644 1 None None None 148642938 Nonpathogen - pyruvoyl-dependent arginine decarboxylase, PdaD Msm_0878 16 COG1945 COG1945, Uncharacterized conserved protein Function unknown 148642618 Common - pyruvate:ferredoxin oxidoreductase, delta subunit, PorD Msm_0558 82 COG1144 COG1144, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit Energy production and conversion 148643451 Common - predicted sugar phosphate isomerase involved in capsule formation, GutQ Msm_1391 116 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 148643201 Common - tryptophan synthase, alpha subunit, TrpA Msm_1141 218 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 148643245 Common - methylated-DNA-[protein]-cysteine S-methyltransferase Msm_1185 218 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 148643578 Nonpathogen - IS element (transposase remnant) Msm_1518 3 None None None 148643490 Common - ribosomal protein L13p Msm_1430 113 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 148643040 Common - rod shape-determining protein, MreB/Mrl family Msm_0980 235 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 148642928 Nonpathogen - hypothetical protein Msm_0868 1 None None None 148642489 Common - biotin biosynthesis protein, BioY Msm_0429 116 COG1268 BioY, Uncharacterized conserved protein General function prediction only 148643762 Common - UDP-glucose 4-epimerase Msm_1702 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 148642589 Nonpathogen - hypothetical protein Msm_0529 1 None None None 148643700 Nonpathogen - DNA intergrase/recombinase, phage integrase family Msm_1640 3 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 148642572 Nonpathogen - NMD3-related protein (nonsense mediated mRNA decay) Msm_0512 33 COG1499 NMD3, NMD protein affecting ribosome stability and mRNA decay Translation, ribosomal structure and biogenesis 148643728 Nonpathogen - hypothetical protein Msm_1668 1 None None None 148643455 Common - iron(III) ABC transporter, ATPase component Msm_1395 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 148643649 Common - transposase, RNaseH-like family Msm_1589 29 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 148643530 Nonpathogen - hypothetical protein Msm_1470 1 None None None 148642085 Common - acyl-CoA synthetase Msm_0025 225 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 148643784 Nonpathogen - hypothetical protein Msm_1724 3 None None None 148643830 Common - hypothetical protein Msm_1770 11 COG3815 COG3815, Predicted membrane protein Function unknown 148642652 Nonpathogen - hypothetical protein Msm_0592 3 COG3480 SdrC, Predicted secreted protein containing a PDZ domain Signal transduction mechanisms 148642705 Common - ATP-dependent DNA ligase, Cdc9 Msm_0645 108 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 148643029 Nonpathogen - predicted metal-binding transcription factor Msm_0969 14 COG4008 COG4008, Predicted metal-binding transcription factor Transcription 148643237 Common - replication factor C large subunit Msm_1177 160 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 148642178 Common - cell wall biosynthesis protein, MurD-like peptide ligase family Msm_0118 7 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 148643616 Common - hypothetical protein Msm_1556 35 COG3274 COG3274, Uncharacterized protein conserved in bacteria Function unknown 148642094 Nonpathogen - hypothetical protein Msm_0034 1 None None None 148642921 Common - flavodoxin Msm_0861 31 COG0716 FldA, Flavodoxins Energy production and conversion 148643488 Nonpathogen - DNA-directed RNA polymerase subunit D Msm_1428 34 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 148643667 Nonpathogen - hypothetical protein Msm_1607 2 None None None 148642192 Common - hypothetical protein Msm_0132 97 COG1720 COG1720, Uncharacterized conserved protein Function unknown 148642317 Nonpathogen - hypothetical protein Msm_0257 2 None None None 148643493 Nonpathogen - DNA-directed RNA polymerase, subunit K, RpoK Msm_1433 32 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 148642684 Nonpathogen nusG transcription antitermination protein NusG Msm_0624 34 COG0250 NusG, Transcription antiterminator Transcription 148642065 Nonpathogen - hypothetical protein Msm_0005 1 None None None 148643020 Common - cation transport ATPase, HAD family Msm_0960 231 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 148643000 Common - myo-inositol-1-phosphate synthase Msm_0940 55 COG1260 INO1, Myo-inositol-1-phosphate synthase Lipid metabolism 148643342 Common - putative adhesin-like protein Msm_1282 10 COG2373 COG2373, Large extracellular alpha-helical protein General function prediction only 148643476 Nonpathogen - hypothetical protein Msm_1416 2 COG4013 COG4013, Uncharacterized protein conserved in archaea Function unknown 148642821 Nonpathogen rpl4lp 50S ribosomal protein L4P Msm_0761 34 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 148642496 Nonpathogen - V-type ATP synthase subunit F Msm_0436 4 COG1436 NtpG, Archaeal/vacuolar-type H+-ATPase subunit F Energy production and conversion 148642395 Common - glutamyl-tRNA(Gln) amidotransferase subunit E Msm_0335 213 COG2511 GatE, Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain) Translation, ribosomal structure and biogenesis 148643829 Nonpathogen - hypothetical protein Msm_1769 1 COG4307 COG4307, Uncharacterized protein conserved in bacteria Function unknown 148642541 Common - TfuA-like protein Msm_0481 25 COG3482 COG3482, Uncharacterized conserved protein Function unknown 148642527 Common - NADP-dependent glyceraldehyde-3-phosphate dehydrogenase Msm_0467 224 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 148642969 Common - DNA-directed RNA polymerase subunit alpha Msm_0909 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 148642162 Common - methionine synthase Msm_0102 138 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 148642829 Common - fumarate hydratase, class I Msm_0769 148 COG1838 FumA, Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain Energy production and conversion 148642942 Common - 3-chlorobenzoate-3,4-dioxygenase dyhydrogenase Msm_0882 193 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 148642438 Common - SAM-dependent methyltransferase Msm_0378 30 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 148643185 Nonpathogen - predicted endoglucanase (CobN-related) Msm_1125 1 COG4278 COG4278, Uncharacterized conserved protein Function unknown 148642677 Common - thiamine biosynthesis ATP pyrophosphatase, ThiI Msm_0617 97 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 148642383 Nonpathogen - hypothetical protein Msm_0323 5 COG4039 COG4039, Predicted membrane protein Function unknown 148642282 Common - flavoprotein (Metallo-beta-lactamase superfamily), FpaA Msm_0222 79 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 148643421 Nonpathogen - predicted pseudouridylate synthase Msm_1361 31 COG1258 COG1258, Predicted pseudouridylate synthase Translation, ribosomal structure and biogenesis 148642974 Nonpathogen - predicted O-linked GlcNAc transferase Msm_0914 1 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 148642901 Nonpathogen - photosynthetic reaction centre cytoplasmic domain containing protein Msm_0841 3 COG1873 COG1873, Uncharacterized conserved protein Function unknown 148643684 Nonpathogen - hypothetical protein Msm_1624 4 COG2456 COG2456, Uncharacterized conserved protein Function unknown 148642548 Common - carbamoylphosphate synthase, large subunit, CarB Msm_0488 236 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 148642455 Common - ferredoxin, iron-sulfur binding Msm_0395 26 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 148642129 Nonpathogen - hypothetical protein Msm_0069 5 COG1710 COG1710, Uncharacterized protein conserved in archaea Function unknown 148642668 Nonpathogen - putative metal-binding protein Msm_0608 2 None None None 148643236 Common rfc replication factor C small subunit Msm_1176 249 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 148643515 Common - L,L-diaminopimelate aminotransferase Msm_1455 221 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 148642554 Common - quinolinate synthetase Msm_0494 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 148643642 Common - hypothetical protein Msm_1582 50 COG2035 COG2035, Predicted membrane protein Function unknown 148642426 Nonpathogen - hypothetical protein Msm_0366 1 None None None 148643406 Nonpathogen - hypothetical protein Msm_1346 1 None None None 148642724 Common - multimeric flavodoxin, NADPH-dependent FMN reductase family Msm_0664 45 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 148643708 Nonpathogen - hypothetical protein Msm_1648 1 None None None 148642131 Common metG methionyl-tRNA synthetase Msm_0071 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 148643809 Nonpathogen - hypothetical protein Msm_1749 4 None None None 148643713 Nonpathogen - hypothetical protein Msm_1653 1 None None None 148642197 Common - putative flagellar protein D/E Msm_0137 15 None None None 148642701 Common - prephenate dehydrogenase Msm_0641 99 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 148642517 Common - D-3-phosphoglycerate dehydrogenase, SerA Msm_0457 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 148642336 Nonpathogen - hypothetical protein Msm_0276 4 None None None 148642566 Nonpathogen purP 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase Msm_0506 20 COG1759 COG1759, ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases) General function prediction only 148642606 Nonpathogen - hypothetical protein Msm_0546 1 None None None 148643507 Common - hypothetical protein Msm_1447 39 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 148643835 Common - putative topoisomerase IV, subunit A Msm_1775 2 None None None 148643221 Nonpathogen - hypothetical protein Msm_1161 1 None None None 148642523 Common - predicted tRNA(His) guanylyltransferase Msm_0463 17 COG4021 COG4021, Uncharacterized conserved protein Function unknown 148643820 Nonpathogen - hypothetical protein Msm_1760 1 None None None 148642657 Common - type II/IV secretion system protein kinase, GspE Msm_0597 220 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 148642874 Common - phosphoribosylformylglycinamidine synthase-related protein (selenophosphate synthetase) Msm_0814 134 COG2144 COG2144, Selenophosphate synthetase-related proteins General function prediction only 148643337 Nonpathogen - hypothetical protein Msm_1277 3 None None None 148642879 Nonpathogen - putative transcription regulator, ArsR family Msm_0819 11 None None None 148642894 Common - chorismate mutase Msm_0834 14 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 148642681 Nonpathogen rplP0 acidic ribosomal protein P0 Msm_0621 33 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 148643374 Nonpathogen - hypothetical protein Msm_1314 1 None None None 148642242 Nonpathogen - small nuclear ribonucleoprotein Msm_0182 32 COG1958 LSM1, Small nuclear ribonucleoprotein (snRNP) homolog Transcription 148642372 Common - [NiFe]-hydrogenase-3-type complex, large subunit/NADH:quinone oxidoreductase (complex I), subunit 49K/NdhH/NuoD Msm_0312 192 COG3261 HycE, Ni,Fe-hydrogenase III large subunit Energy production and conversion 148643212 Nonpathogen - hypothetical protein Msm_1152 1 None None None 148642985 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit gamma Msm_0925 71 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 148642881 Common - orotate phosphoribosyltransferase, PyrE Msm_0821 166 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 148642164 Nonpathogen - hypothetical protein Msm_0104 10 COG4081 COG4081, Uncharacterized protein conserved in archaea Function unknown 148642847 Common - Fe-S oxidoreductase Msm_0787 76 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 148642688 Common - hypothetical protein Msm_0628 20 COG1751 COG1751, Uncharacterized conserved protein Function unknown 148643853 Nonpathogen - hypothetical protein Msm_1793 3 None None None 148643141 Common - transcriptional regulator (enhancer-binding protein), DNA2/NAM7 helicase family Msm_1081 93 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 148642507 Common - fumarate hydratase, alpha subunit Msm_0447 113 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 148642649 Common - ferrous iron transport protein B, FeoB Msm_0589 153 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 148642267 Common - predicted DNA-binding protein Msm_0207 35 COG1342 COG1342, Predicted DNA-binding proteins General function prediction only 148643590 Common - putative nucleic acid-binding protein Msm_1530 3 COG2405 COG2405, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 148642271 Nonpathogen - hypothetical protein Msm_0211 1 None None None 148642363 Common - peptide/nickel ABC transporter, ATP-binding component, DppD Msm_0303 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 148643736 Nonpathogen - hypothetical protein Msm_1676 1 None None None 148643776 Common - adhesin-like protein Msm_1716 8 None None None 148642232 Nonpathogen - hypothetical protein Msm_0172 1 None None None 148643769 Common - adhesin-like protein Msm_1709 26 None None None 148643380 Common - possible glycosyltransferase Msm_1320 8 None None None 148643548 Common - cobalt ABC transporter, permease component, CbiM Msm_1488 85 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 148643694 Nonpathogen - prefoldin, beta subunit Msm_1634 29 COG1382 GimC, Prefoldin, chaperonin cofactor Posttranslational modification, protein turnover, chaperones 148643625 Common - cobyric acid synthase Msm_1565 160 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 148643011 Nonpathogen - translation initiation factor IF-1A Msm_0951 34 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 148643316 Common - 3,4-dihydroxy-2-butanone 4-phosphate synthase, RibB Msm_1256 229 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 148642544 Common - inosine-5'-monophosphate dehydrogenase related protein Msm_0484 33 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 148642634 Nonpathogen - hypothetical protein Msm_0574 6 COG4019 COG4019, Uncharacterized protein conserved in archaea Function unknown 148643050 Common - nitrate/sulfonate/bicarbonate ABC transporter, ATPase component Msm_0990 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 148643431 Common - diaminopimelate decarboxylase, LysA Msm_1371 217 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 148642223 Common - conserved hypothetical proetin predicted to be involved in DNA repair Msm_0163 Msm_0163 35 COG1343 COG1343, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 148643560 Nonpathogen - ssDNA exonuclease, RecJ Msm_1500 25 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 148643088 Common - predicted ATPase, PP-loop family Msm_1028 161 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 148642612 Nonpathogen - sulfur transfer protein involved in thiamine biosynthesis Msm_0552 1 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 148642902 Common - histone acetyltransferase, radical SAM superfamily Msm_0842 73 COG1243 ELP3, Histone acetyltransferase Transcription / Chromatin structure and dynamics 148642124 Nonpathogen - hypothetical protein Msm_0064 4 COG4066 COG4066, Uncharacterized protein conserved in archaea Function unknown 148643813 Common - hypothetical protein Msm_1753 20 None None None 148642410 Common - 2-isopropylmalate synthase, LeuA Msm_0350 221 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 148642070 Common - N-acetyltransferase, GNAT family Msm_0010 12 COG0456 RimI, Acetyltransferases General function prediction only 148643472 Common - tungsten formylmethanofuran dehydrogenase, subunit B, FwdB Msm_1412 110 COG1029 FwdB, Formylmethanofuran dehydrogenase subunit B Energy production and conversion 148643687 Common - glycosyltransferase, GT2 family Msm_1627 202 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 148643275 Common - cobyrinic acid a,c-diamide synthase, CbiA Msm_1215 136 COG1797 CobB, Cobyrinic acid a,c-diamide synthase Coenzyme metabolism 148643445 Common - predicted acyltransferase Msm_1385 7 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 148643652 Common - polysaccharide/polyol phosphate ABC transporter, ATPase component Msm_1592 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 148642691 Nonpathogen - transcription initiation factor E subunit alpha Msm_0631 29 COG1675 TFA1, Transcription initiation factor IIE, alpha subunit Transcription 148643018 Nonpathogen - predicted 1,4-beta-cellobiosidase Msm_0958 1 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 148642741 Common - hypothetical protein Msm_0681 2 None None None 148642329 Nonpathogen - predicted transcriptional regulator (lambda repressor-like) Msm_0269 20 COG2522 COG2522, Predicted transcriptional regulator General function prediction only 148642783 Common - 3-isopropylmalate dehydratase, LeuC Msm_0723 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 148642412 Common - predicted DNA modification methylase Msm_0352 39 COG1041 COG1041, Predicted DNA modification methylase DNA replication, recombination, and repair 148643671 Common - molybdate ABC transporter, ATPase component Msm_1611 249 COG1118 CysA, ABC-type sulfate/molybdate transport systems, ATPase component Inorganic ion transport and metabolism 148643743 Nonpathogen - hypothetical protein Msm_1683 1 None None None 148643793 Common - rubrerythrin Msm_1733 79 COG1592 COG1592, Rubrerythrin Energy production and conversion 148643252 Common - hypothetical protein Msm_1192 39 COG1679 COG1679, Uncharacterized conserved protein Function unknown 148642136 Nonpathogen - hypothetical protein Msm_0076 1 None None None 148643128 Common - putative monovalent cation/H+ antiporter subunit B Msm_1068 14 COG2111 MnhB, Multisubunit Na+/H+ antiporter, MnhB subunit Inorganic ion transport and metabolism 148643149 Nonpathogen - hypothetical protein Msm_1089 1 None None None 148642353 Common - cation transport ATPase, HAD family Msm_0293 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 148642340 Common - predicted ATPase (AAA+ superfamily) Msm_0280 32 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 148643039 Common - ribonuclease HII, RnhB Msm_0979 213 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 148643075 Nonpathogen - methyl-coenzyme M reductase, alpha subunit, McrA Msm_1015 14 COG4058 McrA, Methyl coenzyme M reductase, alpha subunit Coenzyme metabolism 148643072 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit C Msm_1012 14 COG4061 MtrC, Tetrahydromethanopterin S-methyltransferase, subunit C Coenzyme metabolism 148642940 Common - UDP-N-acetylmuramyl tripeptide synthetase (Mur ligase) Msm_0880 30 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 148642590 Nonpathogen - predicted O-linked GlcNAc transferase Msm_0530 4 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 148642561 Common - phycocyanin alpha phycocyanobilin lyase, CpcE Msm_0501 33 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 148643553 Common - hypothetical protein Msm_1493 4 COG1714 COG1714, Predicted membrane protein/domain Function unknown 148642182 Common - predicted ATPase Msm_0122 105 COG0433 COG0433, Predicted ATPase General function prediction only 148643805 Common - predicted type II restriction enzyme, methylase subunit Msm_1745 21 None None None 148643217 Nonpathogen - hypothetical protein Msm_1157 1 None None None 148642762 Nonpathogen - prefoldin subunit alpha Msm_0702 29 COG1730 GIM5, Predicted prefoldin, molecular chaperone implicated in de novo protein folding Posttranslational modification, protein turnover, chaperones 148642214 Common - homoserine dehydrogenase Msm_0154 217 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 148642156 Common - undecaprenyl pyrophosphate synthase, UppS Msm_0096 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 148642111 Common - adhesin-like protein Msm_0051 10 None None None 148642593 Nonpathogen - putative IS element (transposase remnant) Msm_0533 3 None None None 148643541 Common - DNA-directed DNA polymerase, family B, PolB Msm_1481 52 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 148643113 Common - IMP dehydrogenase related protein Msm_1053 165 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 148642866 Common - polar amino acid ABC transporter, permease component Msm_0806 174 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 148642407 Common - putative pyridoxal phosphate-dependent enzyme Msm_0347 16 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 148643132 Common - putative monovalent cation/H+ antiporter subunit C Msm_1072 36 COG1006 MnhC, Multisubunit Na+/H+ antiporter, MnhC subunit Inorganic ion transport and metabolism 148642775 Common - predicted GTPase Msm_0715 249 COG1163 DRG, Predicted GTPase General function prediction only 148643569 Nonpathogen - hypothetical protein Msm_1509 1 None None None 148643396 Common - heterodisulfide reductase, subunit A, HdrA Msm_1336 48 COG1148 HdrA, Heterodisulfide reductase, subunit A and related polyferredoxins Energy production and conversion 148642908 Common - predicted sugar kinase, GHMP kinase family Msm_0848 37 COG1907 COG1907, Predicted archaeal sugar kinases General function prediction only 148643443 Common - anaerobic ribonucleoside-triphosphate reductase, NrdD Msm_1383 106 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 148643777 Nonpathogen - predicted transporter Msm_1717 10 COG4827 COG4827, Predicted transporter General function prediction only 148642084 Nonpathogen - hypothetical protein Msm_0024 1 None None None 148642726 Common - hypothetical protein Msm_0666 120 COG1690 RtcB, Uncharacterized conserved protein Function unknown 148643014 Nonpathogen - predicted RNA-binding protein Msm_0954 34 COG1094 COG1094, Predicted RNA-binding protein (contains KH domains) General function prediction only 148642917 Common - antimicrobial peptide ABC transporter, ATPase component Msm_0857 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 148642359 Common - hypothetical protein Msm_0299 8 None None None 148642661 Nonpathogen - putative transposase Msm_0601 4 None None None 148642419 Common - cell wall biosynthesis protein, MurD-like peptide ligase family Msm_0359 196 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 148642814 Nonpathogen - translation initiation factor Sui1 Msm_0754 44 COG0023 SUI1, Translation initiation factor 1 (eIF-1/SUI1) and related proteins Translation, ribosomal structure and biogenesis 148643385 Common - predicted polysaccharide/polyol phosphate ABC transporter, permease component Msm_1325 143 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 148643192 Nonpathogen - ribosome biogenesis protein Nop10 Msm_1132 22 COG2260 COG2260, Predicted Zn-ribbon RNA-binding protein Translation, ribosomal structure and biogenesis 148643575 Common - lipopolysaccharide cholinephosphotransferase, LicD family Msm_1515 17 COG3475 COG3475, LPS biosynthesis protein Cell envelope biogenesis, outer membrane 148643101 Common - DNA-dependent DNA polymerase I, PolB1 Msm_1041 67 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 148643682 Nonpathogen - riboflavin synthase Msm_1622 22 COG1731 COG1731, Archaeal riboflavin synthase Coenzyme metabolism 148642534 Nonpathogen - hypothetical protein Msm_0474 1 None None None 148642797 Common - adenylate kinase Msm_0737 26 COG2019 AdkA, Archaeal adenylate kinase Nucleotide transport and metabolism 148643176 Common - adhesin-like protein Msm_1116 37 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 148642993 Common - cobalamin-5-phosphate synthase, CobS Msm_0933 119 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 148642714 Common - carbonic anhydrases/acetyltransferase, isoleucine patch superfamily Msm_0654 217 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 148642805 Common rpl6p 50S ribosomal protein L6P Msm_0745 59 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 148642256 Nonpathogen - DNA-dependent RNA polymerase, subunit E, RpoE Msm_0196 23 COG2093 COG2093, DNA-directed RNA polymerase, subunit E'' Transcription 148643108 Common - phosphopantothenoylcysteine synthetase/decarboxylase Msm_1048 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 148642857 Nonpathogen - archaeosine tRNA-ribosyltransferase Msm_0797 12 COG1549 COG1549, Queuine tRNA-ribosyltransferases, contain PUA domain Translation, ribosomal structure and biogenesis 148642997 Nonpathogen - HD superfamily hydrolase Msm_0937 7 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 148643123 Common - energy-converting hydrogenase B, subunit N, EhbN Msm_1063 195 COG3261 HycE, Ni,Fe-hydrogenase III large subunit Energy production and conversion 148643680 Common - cobalt ABC transporter, permease component, CbiQ Msm_1620 49 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 148642932 Common - glucosamine:fructose-6-phosphate aminotransferase (isomerizing), AgaS Msm_0872 233 COG2222 AgaS, Predicted phosphosugar isomerases Cell envelope biogenesis, outer membrane 148643030 Nonpathogen - hypothetical protein Msm_0970 2 None None None 148643347 Common - phosphoribosylaminoimidazole carboxylase (NCAIR mutase), PurE Msm_1287 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 148642289 Nonpathogen - hypothetical protein Msm_0229 6 COG4053 COG4053, Uncharacterized protein conserved in archaea Function unknown 148642936 Common - arginase/agmatinase/formimionoglutamate hydrolase, SpeB Msm_0876 149 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 148642451 Common - indolepyruvate oxidoreductase subunit B Msm_0391 91 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 148642108 Common - hypothetical protein Msm_0048 6 None None None 148643785 Nonpathogen - hypothetical protein Msm_1725 8 None None None 148642988 Common - 2-oxoglutarate ferredoxin oxidoreductase, delta subunit, KorD Msm_0928 54 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 148643362 Common - hypothetical protein Msm_1302 15 COG4289 COG4289, Uncharacterized protein conserved in bacteria Function unknown 148643780 Nonpathogen - DNA-directed RNA polymerase, subunit M, RpoM Msm_1720 33 COG1594 RPB9, DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS Transcription 148642075 Nonpathogen - hypothetical protein Msm_0015 1 None None None 148642298 Common - precorrin-6B methylase, CbiT Msm_0238 95 COG2242 CobL, Precorrin-6B methylase 2 Coenzyme metabolism 148643447 Common - lysyl-tRNA synthetase (class I), LysS Msm_1387 77 COG1384 LysS, Lysyl-tRNA synthetase (class I) Translation, ribosomal structure and biogenesis 148643846 Common - O-linked GlcNAc transferase Msm_1786 23 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 148642773 Nonpathogen - predicted nucleotide kinase Msm_0713 31 COG1936 COG1936, Predicted nucleotide kinase (related to CMP and AMP kinases) Nucleotide transport and metabolism 148643726 Nonpathogen - hypothetical protein Msm_1666 1 None None None 148642631 Nonpathogen - hypothetical protein Msm_0571 7 COG4018 COG4018, Uncharacterized protein conserved in archaea Function unknown 148643081 Nonpathogen - hypothetical protein Msm_1021 14 COG4052 COG4052, Uncharacterized protein related to methyl coenzyme M reductase subunit C General function prediction only 148643453 Common - iron(III) ABC transporter, substrate-binding component Msm_1393 98 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 148643689 Common - IMP dehydrogenase/GMP reductase, GuaB Msm_1629 244 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 148642388 Nonpathogen - hypothetical protein Msm_0328 2 None None None 148642405 Common - GMP synthase subunit B Msm_0345 238 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 148642475 Common - uridylate kinase, PyrH Msm_0415 239 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 148642465 Common - predicted metal-dependent DNase, TatD-related family Msm_0405 41 COG1099 COG1099, Predicted metal-dependent hydrolases with the TIM-barrel fold General function prediction only 148643065 Common - GTP:adenosylcobinamide-phosphate guanylyltransferase Msm_1005 39 COG2266 COG2266, GTP:adenosylcobinamide-phosphate guanylyltransferase Coenzyme metabolism 148642338 Nonpathogen - hypothetical protein Msm_0278 1 None None None 148642580 Common - thymidylate kinase, Tmk Msm_0520 163 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 148642194 Common - M42 glutamyl aminopeptidase/endo-glucanase Msm_0134 89 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 148643436 Nonpathogen - DNA-directed RNA polymerase subunit F Msm_1376 21 COG1460 COG1460, Uncharacterized protein conserved in archaea Function unknown 148643730 Nonpathogen - hypothetical protein Msm_1670 1 None None None 148643325 Nonpathogen - hypothetical protein Msm_1265 3 COG5440 COG5440, Uncharacterized conserved protein Function unknown 148642207 Common - CTP synthetase Msm_0147 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 148642967 Nonpathogen - 50S ribosomal protein L30e Msm_0907 28 COG1911 RPL30, Ribosomal protein L30E Translation, ribosomal structure and biogenesis 148642779 Common - phosphoserine phosphatase, HAD family, SerB Msm_0719 159 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 148643043 Nonpathogen - hypothetical protein Msm_0983 6 COG1627 COG1627, Uncharacterized protein conserved in archaea Function unknown 148643481 Common - hypothetical protein Msm_1421 18 COG4907 COG4907, Predicted membrane protein Function unknown 148643157 Common - Zn-dependent hydrolase Msm_1097 125 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 148642482 Nonpathogen - hypothetical protein Msm_0422 4 None None None 148642498 Common - vacuolar-type H+-transporting ATP synthase, subunit E Msm_0438 31 COG1390 NtpE, Archaeal/vacuolar-type H+-ATPase subunit E Energy production and conversion 148642169 Nonpathogen - conserved hypothetical membrane-spanning protein Msm_0109 Msm_0109 2 None None None 148643499 Common - mevalonate kinase Msm_1439 49 COG1577 ERG12, Mevalonate kinase Lipid metabolism 148642436 Common - alcohol dehydrogenase (zinc-binding), GroES-like protein Msm_0376 61 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 148642823 Nonpathogen - hypothetical protein Msm_0763 21 COG2106 COG2106, Uncharacterized conserved protein Function unknown 148642960 Common - 30S ribosomal protein S7P Msm_0900 241 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 148642682 Common rpl1P 50S ribosomal protein L1P Msm_0622 248 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 148643243 Common - ATPase, PilT family Msm_1183 90 COG1855 COG1855, ATPase (PilT family) General function prediction only 148643099 Common - phosphoribosylaminoimidazole synthetase Msm_1039 233 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 148642794 Common - cytidylate kinase Msm_0734 36 COG1102 Cmk, Cytidylate kinase Nucleotide transport and metabolism 148642284 Nonpathogen - hypothetical protein Msm_0224 9 None None None 148642305 Common - proteasome subunit alpha Msm_0245 36 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 148642381 Nonpathogen - hypothetical protein Msm_0321 8 COG4037 COG4037, Predicted membrane protein Function unknown 148642377 Common - NADH dehydrogenase (ubiquinone), subunit 1 Msm_0317 73 COG0650 HyfC, Formate hydrogenlyase subunit 4 Energy production and conversion 148642319 Nonpathogen - hypothetical protein Msm_0259 1 COG4640 COG4640, Predicted membrane protein Function unknown 148642092 Nonpathogen - hypothetical protein Msm_0032 1 None None None 148642225 Common - predicted exonuclease Msm_0165 35 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 148643414 Nonpathogen - DNA-directed RNA polymerase subunit M, RpoM Msm_1354 33 COG1594 RPB9, DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS Transcription 148642118 Common - DNA helicase II Msm_0058 236 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 148642101 Nonpathogen - hypothetical protein Msm_0041 1 None None None 148643764 Common - glutamine phosphoribosylpyrophosphate amidotransferase, PurF Msm_1704 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 148642520 Common - predicted transposase Msm_0460 32 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 148643519 Common - multidrug efflux permease, AraJ Msm_1459 218 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 148642146 Common - (2R)-phospho-3-sulfolactate synthase, ComA Msm_0086 24 COG1809 COG1809, Uncharacterized conserved protein Function unknown 148643532 Nonpathogen - hypothetical protein Msm_1472 8 COG4079 COG4079, Uncharacterized protein conserved in archaea Function unknown 148642915 Common truA tRNA pseudouridine synthase A Msm_0855 190 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 148643369 Common - dTDP-D-glucose 4,6-dehydratase, RfbB Msm_1309 234 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 148643428 Common - N-acetylornithine aminotransferase, ArgD Msm_1368 238 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 148642300 Common - molybdopterin-guanine dinucleotide biosynthesis protein A, MobA Msm_0240 80 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 148643620 Common - polysaccharide biosynthesis protein, MviN-like family Msm_1560 156 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 148642443 Common - predicted phosphohydrolase, calcineurin-like superfamily Msm_0383 118 COG1409 Icc, Predicted phosphohydrolases General function prediction only 148642483 Common - glycosyltransferase Msm_0423 122 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 148642655 Common - multidrug ABC transporter, permease component Msm_0595 6 COG4200 COG4200, Uncharacterized protein conserved in bacteria Function unknown 148642311 Nonpathogen - hypothetical protein Msm_0251 1 COG4640 COG4640, Predicted membrane protein Function unknown 148643822 Nonpathogen - hypothetical protein Msm_1762 1 None None None 148643505 Common - predicted transcriptional regulator Msm_1445 39 COG1378 COG1378, Predicted transcriptional regulators Transcription 148642479 Nonpathogen - hypothetical protein Msm_0419 3 COG0393 COG0393, Uncharacterized conserved protein Function unknown 148642171 Nonpathogen - hypothetical protein Msm_0111 1 None None None 148642154 Common - predicted transcription regulator (TetR family) Msm_0094 45 COG1309 AcrR, Transcriptional regulator Transcription 148642571 Nonpathogen - translation initiation factor IF-2 subunit beta Msm_0511 34 COG1601 GCD7, Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain Translation, ribosomal structure and biogenesis 148643153 Nonpathogen - putative transposase Msm_1093 3 None None None 148642926 Common - Zn metalloprotease, TldD Msm_0866 169 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 148643618 Common - SAM-dependent methyltransferase, UbiE family Msm_1558 137 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 148642240 Nonpathogen - hypothetical protein Msm_0180 1 None None None 148642172 Common - ATP-dependent RNA helicase, eIF-4A family Msm_0112 173 COG1205 COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster General function prediction only