Dichelobacter nodosus VCS1703A, complete genome NC_009446 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 146329797 Pathogen - hypothetical protein DNO_0620 1 None None None 146329146 Pathogen - hypothetical protein DNO_0261 1 None None None 146329293 Common surE acid phosphatase SurE DNO_0959 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 146329716 Common proS prolyl-tRNA synthetase DNO_1137 245 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146329802 Common adk adenylate kinase DNO_1071 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 146328772 Common - hypothetical protein DNO_0749 14 COG4387 COG4387, Mu-like prophage protein gp36 Function unknown 146329835 Common cydD ABC-type transporter involved in cytochrome bd biosynthesis DNO_0102 234 COG4988 CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 146329005 Common - hypothetical protein DNO_0696 11 COG0700 SpmB, Uncharacterized membrane protein Function unknown 146329259 Pathogen - hypothetical protein DNO_0432 1 None None None 146329436 Common holB DNA polymerase III, delta' subunit DNO_1214 203 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 146329496 Common atpE ATP synthase F0, C subunit DNO_1147 86 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 146329905 Common hemL glutamate-1-semialdehyde-2,1-aminomutase DNO_1024 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 146329050 Common - cold-shock DNA-binding domain protein DNO_0162 44 COG3326 COG3326, Predicted membrane protein Function unknown 146329191 Pathogen - hypothetical protein DNO_0424 1 None None None 146328843 Common vapA3 virulence-associated protein VapA3 DNO_1040 64 COG3093 VapI, Plasmid maintenance system antidote protein General function prediction only 146329234 Common - hypothetical protein DNO_1187 116 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 146329265 Common pheT phenylalanyl-tRNA synthetase, beta subunit DNO_1056 244 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 146329885 Common - hydroxymethylglutaryl-CoA synthase DNO_0799 64 COG3425 PksG, 3-hydroxy-3-methylglutaryl CoA synthase Lipid metabolism 146328941 Common - rhodanese-like domain protein DNO_1227 106 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 146329250 Common nrdD anaerobic ribonucleoside triphosphate reductase DNO_0910 65 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 146328759 Pathogen - hypothetical protein DNO_0599 1 None None None 146329555 Common aceE pyruvate dehydrogenase subunit E1 DNO_0544 164 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 146328750 Common - hypothetical protein DNO_0783 3 COG5293 COG5293, Uncharacterized protein conserved in bacteria Function unknown 146329214 Common - oligopeptidase, M3 family DNO_0242 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 146329580 Common rfaE ADP-heptose synthase DNO_0095 190 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 146328666 Common rpsG 30S ribosomal protein S7 DNO_1279 239 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 146329855 Common regA2 regulatory protein RegA2 DNO_0773 28 COG2932 COG2932, Predicted transcriptional regulator Transcription 146329229 Common - ABC-2 type transporter family protein DNO_0335 90 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 146329113 Common - heptosyl transferase I DNO_1031 76 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 146329814 Common - hydrolase, alpha-beta fold family protein DNO_0582 140 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 146329776 Common - chromosome segregation SMC family protein DNO_0609 181 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 146328965 Common - Staphylococcal nuclease family protein DNO_0115 75 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 146329160 Common cydC ABC-type transporter involved in cytochrome bd biosynthesis DNO_0101 245 COG4987 CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 146328790 Common ftsA cell division protein FtsA DNO_0977 176 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 146329525 Common folC folylpolyglutamate synthase DNO_0404 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 146328702 Common - oxidoreductase, aldo-keto reductase family DNO_0829 173 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 146328718 Common gidB glucose inhibited division protein GidB DNO_1150 204 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 146329767 Common - bacterial extracellular solute-binding family protein DNO_0377 4 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 146329365 Common lnt apolipoprotein N-acyltransferase DNO_0247 163 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 146329467 Common xth-1 exodeoxyribonuclease III DNO_0431 196 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 146329400 Common ubiE ubiquinone-menaquinone biosynthesis methyltransferase DNO_0439 216 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 146328856 Common - ABC transporter family protein DNO_0094 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 146329147 Common - long-chain-fatty-acid--CoA ligase DNO_1002 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 146329421 Common fimV type IV fimbrial biogenesis protein FimV DNO_0712 33 COG3170 FimV, Tfp pilus assembly protein FimV Cell motility and secretion / Intracellular trafficking and secretion 146328985 Common - outer membrane multidrug efflux protein DNO_1192 111 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 146328698 Common vrlJ conserved hypothetical protein VrlJ DNO_0182 5 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 146329587 Common yfiA sigma-54 modulation protein/S30EA ribosomal family protein DNO_0614 63 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 146329356 Common ksgA rRNA adenine dimethylase DNO_0922 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 146328864 Common - phosphoserine aminotransferase DNO_0670 100 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 146329062 Common ruvB Holliday junction DNA helicase B DNO_1176 224 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 146328740 Common - hypothetical protein DNO_0159 12 None None None 146328818 Pathogen - chorismate mutase family protein DNO_0926 1 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 146329865 Common purN phosphoribosylglycinamide formyltransferase DNO_0207 222 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 146329422 Common - TatD family DNase DNO_0415 235 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 146328977 Common uvrC excinuclease ABC, C subunit DNO_0305 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 146328644 Common serS seryl-tRNA synthetase DNO_1065 244 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 146329847 Common - OsmC-like family protein DNO_1109 48 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 146329547 Common hemB delta-aminolevulinic acid dehydratase DNO_0510 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 146329403 Common ahpC alkyl hydroperoxide reductase C22 subunit DNO_0143 216 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 146329541 Common pilT twitching motility protein PilT DNO_0675 218 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 146329136 Common sucA 2-oxoglutarate dehydrogenase, E1 component DNO_0329 147 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 146329896 Common tatC sec-independent protein translocase TatC DNO_0451 205 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 146328731 Common cysS cysteinyl-tRNA synthetase class I DNO_0208 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146328745 Common dapA dihydrodipicolinate synthase DNO_1114 232 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 146328693 Common - bacterial extracellular solute-binding family protein DNO_1345 38 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 146329375 Common dnaN DNA polymerase III, beta subunit DNO_0002 209 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 146329126 Common - hypothetical protein DNO_0318 7 None None None 146329725 Common gepA hypothetical protein DNO_0260 26 COG3600 GepA, Uncharacterized phage-associated protein Function unknown 146329622 Common - hypothetical protein DNO_1132 18 None None None 146329678 Common - ABC transporter domain protein DNO_0444 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 146329394 Common spoT guanosine-3',5'-bis(diphosphate) 3'- pyrophosphohydrolase DNO_1020 206 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 146328970 Pathogen - hypothetical protein DNO_0594 1 None None None 146329220 Common - aldo/keto reductase family protein DNO_1295 169 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 146329625 Common - lipoprotein releasing system ATP-binding protein LolD DNO_1229 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 146328901 Common ispZ intracellular septation protein A DNO_0466 91 COG2917 COG2917, Intracellular septation protein A Cell division and chromosome partitioning 146329631 Common - predicted inner membrane peptidase DNO_0048 184 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 146328638 Common - 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain family protein DNO_1136 84 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 146329669 Common - alkaline phosphatase DNO_0105 82 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 146329164 Common - undecaprenol kinase DNO_0291 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 146328686 Common clpX ATP-dependent protease ATP-binding subunit DNO_0228 214 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 146329122 Common glpK glycerol kinase DNO_0213 179 COG0554 GlpK, Glycerol kinase Energy production and conversion 146329318 Common azu azurin DNO_1049 17 COG3241 COG3241, Azurin Energy production and conversion 146329740 Pathogen - hypothetical protein DNO_0232 1 None None None 146328783 Common murD UDP-N-acetylmuramoylalanine-D-glutamate ligase DNO_0983 210 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 146329039 Common pyrE orotate phosphoribosyltransferase DNO_0919 137 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 146329032 Common - peptidase family M48 protein DNO_0795 148 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 146329671 Common rpsQ 30S ribosomal protein S17 DNO_1266 232 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 146329747 Common ung uracil-DNA glycosylase DNO_0631 129 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 146329640 Common - hypothetical protein DNO_0106 35 COG3681 COG3681, Uncharacterized conserved protein Function unknown 146329275 Common - hypothetical protein DNO_0878 49 COG3577 COG3577, Predicted aspartyl protease General function prediction only 146329655 Common - GTPase DNO_0391 172 COG0218 COG0218, Predicted GTPase General function prediction only 146329180 Common - hypothetical protein DNO_0172 19 COG4383 COG4383, Mu-like prophage protein gp29 Function unknown 146329084 Common rplN 50S ribosomal protein L14 DNO_1265 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 146329445 Common - hypothetical protein DNO_0852 86 COG0327 COG0327, Uncharacterized conserved protein Function unknown 146329260 Common - two-component copper resistance response regulator DNO_0901 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 146329244 Common - BioY family protein DNO_1162 109 COG1268 BioY, Uncharacterized conserved protein General function prediction only 146329257 Common - hypothetical protein DNO_1004 208 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 146328656 Common - HAD-superfamily hydrolase DNO_1337 82 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 146329384 Common - hypothetical protein DNO_0516 48 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 146329338 Common - ABC transporter domain protein DNO_0456 249 COG4172 COG4172, ABC-type uncharacterized transport system, duplicated ATPase component General function prediction only 146328838 Common engA GTP-binding family protein DNO_0520 235 COG1160 COG1160, Predicted GTPases General function prediction only 146329174 Common mviN virulence factor MviN family protein DNO_0862 183 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 146329332 Common - GlpG-like proten DNO_1330 56 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 146328872 Common lysS lysyl-tRNA synthetase DNO_0938 249 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 146328882 Common - glycosyl transferase family protein DNO_0339 21 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 146329742 Common brnQ branched-chain amino acid transport system II carrier protein DNO_1103 50 COG1114 BrnQ, Branched-chain amino acid permeases Amino acid transport and metabolism 146329749 Common - SPFH domain - Band 7 family protein DNO_1107 39 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 146329034 Pathogen - hypothetical protein VlrB DNO_0191 1 None None None 146329696 Common ptsI phosphoenolpyruvate-protein phosphotransferase DNO_0118 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 146329662 Common - hypothetical protein DNO_0587 2 None None None 146329017 Common - hypothetical protein DNO_1077 169 COG0344 COG0344, Predicted membrane protein Function unknown 146329102 Common - probable OxrR-like transcriptional regulator, LysR family DNO_0142 185 COG0583 LysR, Transcriptional regulator Transcription 146329686 Common - hypothetical protein DNO_0514 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 146328827 Common - transporter associated domain protein DNO_0936 216 COG4535 CorC, Putative Mg2+ and Co2+ transporter CorC Inorganic ion transport and metabolism 146329704 Common rpoD RNA polymerase sigma-70 factor DNO_1078 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 146329326 Common csy1 hypothetical protein DNO_0167 18 None None None 146329731 Pathogen - hypothetical protein DNO_0566 1 None None None 146329303 Common mdoH glucosyltransferase MdoH DNO_0626 58 COG2943 MdoH, Membrane glycosyltransferase Cell envelope biogenesis, outer membrane 146329305 Common - dipeptidase family protein DNO_0073 101 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 146329837 Pathogen - hypothetical protein DNO_0855 1 COG3113 COG3113, Predicted NTP binding protein (contains STAS domain) General function prediction only 146329480 Common - bacterial extracellular solute-binding family protein DNO_0033 176 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 146329676 Pathogen gepC hypothetical protein DNO_0258 1 COG3326 COG3326, Predicted membrane protein Function unknown 146328825 Pathogen - hypothetical protein DNO_0753 1 None None None 146329476 Common rpsM 30S ribosomal protein S13 DNO_1254 244 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 146329282 Pathogen - hypothetical protein DNO_0103 1 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 146329485 Common rpmH 50S ribosomal protein L34 DNO_0952 197 COG0230 RpmH, Ribosomal protein L34 Translation, ribosomal structure and biogenesis 146329393 Common - HlyD family secretion protein DNO_1190 142 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 146329074 Common - 2-nitropropane dioxygenase family protein DNO_0239 54 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 146329285 Common frdB fumarate reductase, iron-sulfur protein DNO_1027 208 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 146329649 Common rplK 50S ribosomal protein L11 DNO_1286 246 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 146329554 Pathogen - hypothetical protein DNO_0043 1 None None None 146329092 Common - hypothetical protein DNO_0756 8 None None None 146329424 Common fusA translation elongation factor G DNO_1278 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 146329077 Common tufA elongation factor Tu DNO_1277 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 146328927 Common dapF diaminopimelate epimerase DNO_0042 203 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 146329296 Common queA S-adenosylmethionine:tRNA ribosyltransferase- isomerase DNO_0026 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 146329608 Common guaA bifunctional GMP synthase/glutamine amidotransferase protein DNO_0380 240 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 146329756 Common fabA 3-hydroxydecanoyl-(acyl carrier protein) dehydratase DNO_0314 83 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 146329820 Common - glycosyl transferase family protein DNO_0097 48 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 146329871 Common nth endonuclease III DNO_0548 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 146329205 Pathogen - hypothetical protein DNO_0379 1 None None None 146328955 Common vrlG glutamine amidotransferase domain protein VrlG DNO_0185 83 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 146329538 Common galU UTP--glucose-1-phosphate uridylyltransferase DNO_0327 230 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 146329021 Common - type I secretion membrane fusion protein DNO_0549 120 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 146329598 Common pflA pyruvate formate-lyase activating enzyme DNO_1333 86 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 146329291 Common uvrD-1 DNA helicase II DNO_0164 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 146328833 Common hflK HflK protein DNO_0597 127 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 146329272 Pathogen vapG2 virulence-associated protein VapG2 DNO_0269 1 None None None 146329863 Pathogen - hypothetical protein DNO_0671 1 None None None 146328677 Common lepB signal peptidase I DNO_0693 210 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 146329006 Common - 16S rRNA processing protein RimM DNO_1008 168 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 146328926 Common cydA cytochrome bd ubiquinol oxidase, subunit I DNO_0100 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 146328757 Common pdxH pyridoxamine 5'-phosphate oxidase DNO_1023 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 146328868 Common - hypothetical protein DNO_0772 19 None None None 146329614 Common acpP acyl carrier protein DNO_1210 208 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 146329001 Common dnaG DNA primase DNO_1079 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 146329416 Common - hypothetical protein DNO_0130 30 COG3028 COG3028, Uncharacterized protein conserved in bacteria Function unknown 146328893 Common - phosphoglucomutase/phosphomannomutase DNO_0907 232 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 146329345 Pathogen - hypothetical protein DNO_0006 1 None None None 146328728 Common - preprotein translocase, YajC subunit DNO_0040 178 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 146328993 Common - ABC transporter family protein DNO_0454 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 146328791 Common - K+-dependent Na+-Ca+ exchanger related family protein DNO_1111 127 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 146329137 Common recD exonuclease V, alpha subunit DNO_0408 133 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 146329216 Common - DNA-binding protein Hu DNO_0226 212 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 146329714 Common kdsA 2-dehydro-3-deoxyphosphooctonate aldolase DNO_0361 186 COG2877 KdsA, 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase Cell envelope biogenesis, outer membrane 146328809 Common rpsI 30S ribosomal protein S9 DNO_1130 223 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 146329328 Common dnaC DNA replication protein DnaC DNO_0776 113 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 146329321 Common sufS cysteine desulfurase SufS DNO_0834 237 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 146328896 Common atpH ATP synthase F1, delta subunit DNO_1145 123 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 146329574 Common truB tRNA pseudouridine synthase B DNO_0027 244 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 146329115 Common feoB ferrous iron transport protein FeoB DNO_0137 157 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 146328664 Pathogen - hypothetical protein DNO_0762 1 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 146329377 Common - deoxyuridine 5'-triphosphate nucleotidohydrolase DNO_0824 179 COG0756 Dut, dUTPase Nucleotide transport and metabolism 146329543 Common rnpA ribonuclease P protein component DNO_0951 58 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 146328704 Common pilR two-component response regulator PilR DNO_0435 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 146329518 Common purH phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase DNO_0918 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 146329853 Common atpC ATP synthase F1, epsilon subunit DNO_1141 164 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 146329104 Common - endoribonuclease L-PSP family protein DNO_1331 157 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 146328913 Common trpC indole-3-glycerol phosphate synthase DNO_0585 219 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 146328816 Common pheS phenylalanyl-tRNA synthetase, alpha subunit DNO_1055 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 146329804 Common - transposase, IS605 family DNO_1341 76 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 146328963 Common - hypothetical protein DNO_0134 12 None None None 146329358 Common sdaC serine transporter SdaC DNO_1349 38 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 146328774 Common - hypothetical protein DNO_0149 189 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 146329827 Common vrlF conserved hypothetical protein VrlF DNO_0186 3 None None None 146328762 Common - hypothetical protein DNO_0512 88 COG3178 COG3178, Predicted phosphotransferase related to Ser/Thr protein kinases General function prediction only 146329760 Pathogen - hypothetical protein DNO_0241 1 None None None 146329585 Common - SmpA/OmlA family lipoprotein DNO_1064 10 COG2913 SmpA, Small protein A (tmRNA-binding) Translation, ribosomal structure and biogenesis 146329785 Common - GatB-Yqey domain protein DNO_1080 150 COG1610 COG1610, Uncharacterized conserved protein Function unknown 146329619 Common sucB 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase DNO_0331 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 146329816 Common - acyltransferase domain protein DNO_1058 180 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 146328948 Common - hypothetical protein DNO_0022 2 COG2044 COG2044, Predicted peroxiredoxins General function prediction only 146329055 Common ppa inorganic pyrophosphatase DNO_0198 187 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 146328738 Common - hypothetical protein DNO_0467 201 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 146328841 Common pncB nicotinate phosphoribosyltransferase DNO_0196 103 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 146329799 Common nrdG anaerobic ribonucleoside-triphosphate reductase activating protein DNO_0911 9 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 146328726 Pathogen - hypothetical membrane protein DNO_0965 1 None None None 146329388 Common clpB ATP-dependent protease ClpB DNO_0108 216 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 146329833 Common - TPR repeat domain protein DNO_0068 90 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 146329718 Common - outer membrane efflux family protein DNO_0546 32 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 146328848 Common gnd 6-phosphogluconate dehydrogenase, decarboxylating DNO_1236 179 COG0362 Gnd, 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 146329903 Common - hypothetical protein DNO_0425 71 COG1430 COG1430, Uncharacterized conserved protein Function unknown 146329144 Common hsdM type I restriction-modification system, M subunit DNO_0223 159 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 146328987 Common rbfA ribosome-binding factor A DNO_0028 141 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 146329494 Pathogen - hypothetical protein DNO_1033 1 None None None 146329438 Common atpD F0F1 ATP synthase subunit beta DNO_1142 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 146329790 Common - SUF system FeS assembly protein, NifU family DNO_0833 169 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 146329653 Common recJ DNA exonuclease RecJ DNO_0592 192 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 146329455 Common rnfB electron transport complex protein, B subunit DNO_0554 111 COG2878 COG2878, Predicted NADH:ubiquinone oxidoreductase, subunit RnfB Energy production and conversion 146329236 Common - ABC-type lipoprotein releasing system protein LolC DNO_1228 157 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 146329267 Pathogen - hypothetical protein DNO_0893 1 COG4966 PilW, Tfp pilus assembly protein PilW Cell motility and secretion / Intracellular trafficking and secretion 146329887 Common - hypothetical protein DNO_0695 11 COG3314 COG3314, Uncharacterized protein conserved in bacteria Function unknown 146329738 Common - conserved hypothetical lipoprotein DNO_1302 12 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 146328908 Common - hypothetical protein DNO_0760 11 None None None 146329048 Common dprA DNA processing protein DprA DNO_0154 210 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 146329842 Common ppsA phosphoenolpyruvate synthase DNO_0630 234 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 146328716 Common trmU tRNA (5-methylaminomethyl-2-thiouridylate)- methyltransferase DNO_0627 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 146328811 Common - hypothetical protein DNO_0080 32 COG3098 COG3098, Uncharacterized protein conserved in bacteria Function unknown 146329727 Common - polyprenyl synthase DNO_0945 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 146329523 Common - helicase domain protein DNO_0572 131 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 146329627 Common era GTP-binding protein Era DNO_0691 219 COG1159 Era, GTPase General function prediction only 146329152 Common hflX GTP-binding protein HflX DNO_0596 212 COG2262 HflX, GTPases General function prediction only 146329840 Pathogen - hypothetical lipoprotein DNO_0245 1 COG2980 RlpB, Rare lipoprotein B Cell envelope biogenesis, outer membrane 146329898 Common gmhA phosphoheptose isomerase DNO_0290 124 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 146329166 Pathogen - hypothetical protein DNO_0215 1 None None None 146329153 Pathogen - hypothetical protein DNO_0070 1 None None None 146329851 Pathogen - hypothetical protein DNO_0726 1 None None None 146328691 Common ihfA integration host factor, alpha subunit DNO_1057 208 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 146329360 Common thyA thymidylate synthase DNO_0569 140 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 146329316 Common - hypothetical membrane protein DNO_1037 2 COG3503 COG3503, Predicted membrane protein Function unknown 146329745 Common rplQ 50S ribosomal protein L17 DNO_1250 215 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 146329037 Pathogen - hypothetical protein DNO_0406 1 None None None 146329128 Common sufD SufD protein DNO_0835 162 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 146328886 Common recA DNA recombination protein RecA DNO_0288 240 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 146329367 Common - hypothetical protein DNO_0954 167 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 146329667 Common - putative ABC transporter ATP-binding protein DNO_0398 246 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 146328976 Common - quinonprotein alcohol dehydrogenase family protein DNO_0519 99 COG1520 COG1520, FOG: WD40-like repeat Function unknown 146329428 Common sbcC exonuclease SbcC DNO_0366 100 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 146328786 Common - sec-independent protein translocase family protein TatA DNO_0449 6 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 146329167 Pathogen - hypothetical membrane protein DNO_0047 1 None None None 146329098 Common nadE NAD+ synthetase DNO_0197 215 COG0171 NadE, NAD synthase Coenzyme metabolism 146329465 Common tadA adenosine deaminase DNO_0579 209 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 146329491 Common tig trigger factor DNO_0230 214 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 146329849 Common aroQ 3-dehydroquinate dehydratase, type II DNO_0419 169 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 146329405 Common aprV2 acidic extracellular subtilisin-like protease AprV2 DNO_1167 130 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 146329208 Common nusB transcription antitermination factor NusB DNO_0470 133 COG0781 NusB, Transcription termination factor Transcription 146329633 Pathogen - hypothetical protein DNO_0124 1 None None None 146329566 Common hslR ribosome-associated heat shock protein DNO_0912 95 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 146329702 Common - rRNA methyltransferase DNO_0708 158 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 146328854 Pathogen - hypothetical protein DNO_0010 1 None None None 146329774 Common - hypothetical protein DNO_0025 13 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 146329359 Common rplV 50S ribosomal protein L22 DNO_1270 219 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 146329091 Common pilM type IV fimbrial biogenesis protein PilM DNO_0344 49 COG4972 PilM, Tfp pilus assembly protein, ATPase PilM Cell motility and secretion / Intracellular trafficking and secretion 146329584 Common - anaerobic C4-dicarboxylate transporter DNO_0711 36 COG2704 DcuB, Anaerobic C4-dicarboxylate transporter General function prediction only 146329352 Common accC acetyl-CoA carboxylase, biotin carboxylase DNO_0421 235 COG0439 AccC, Biotin carboxylase Lipid metabolism 146328646 Common - peptidase, U32 family DNO_0394 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 146329398 Common chpA chemotaxis protein ChpA DNO_1093 223 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 146329019 Common - hypothetical protein DNO_1203 2 COG2367 PenP, Beta-lactamase class A Defense mechanisms 146328881 Common glpA carbon storage regulator DNO_0284 79 COG1551 CsrA, Carbon storage regulator (could also regulate swarming and quorum sensing) Signal transduction mechanisms 146328931 Common - carboxyl-terminal protease family protein DNO_1034 181 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 146329616 Common xth-2 exodeoxyribonuclease III DNO_0917 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 146329684 Common - glycosyl transferase, group 2 family protein DNO_0870 102 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 146328743 Pathogen - hypothetical protein DNO_0121 1 None None None 146328888 Common - hypothetical protein DNO_0529 26 COG3907 COG3907, PAP2 (acid phosphatase) superfamily protein General function prediction only 146328835 Common rnt ribonuclease T DNO_0307 76 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 146329347 Common def formylmethionine deformylase DNO_0156 214 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 146329660 Common - glutaredoxin-related protein DNO_1301 126 COG0278 COG0278, Glutaredoxin-related protein Posttranslational modification, protein turnover, chaperones 146329682 Common cmk cytidylate kinase DNO_0112 204 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 146328920 Pathogen - hypothetical protein DNO_0316 1 None None None 146329171 Pathogen - hypothetical protein DNO_0560 1 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 146329391 Common - PTS system, fructose IIC subunit DNO_0610 79 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 146329552 Common - D-alanyl-D-alanine carboxypeptidase DNO_0899 156 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 146329694 Common - hypothetical protein DNO_1204 32 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 146329474 Common - membrane-associated zinc metalloprotease, M50 family DNO_0716 209 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 146328650 Common - hypothetical protein DNO_0768 9 COG5377 COG5377, Phage-related protein, predicted endonuclease DNA replication, recombination, and repair 146329575 Common - hypothetical protein DNO_1138 3 None None None 146329280 Common rne ribonuclease E DNO_0302 194 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 146328952 Common mdoG glucan biosynthesis protein G DNO_0625 50 COG3131 MdoG, Periplasmic glucans biosynthesis protein Inorganic ion transport and metabolism 146328800 Common uvrA excinuclease ABC, A subunit DNO_0076 235 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 146329340 Common - conserved hypothetical lipoprotein DNO_1226 132 COG1704 LemA, Uncharacterized conserved protein Function unknown 146328879 Pathogen - hypothetical protein DNO_1169 1 None None None 146329139 Common - N-acetylmuramoyl-L-alanine amidase DNO_0311 178 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 146329262 Common - peptidyl-prolyl cis-trans isomerase, FKBP-type DNO_0012 135 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 146329082 Common kdsB 3-deoxy-D-manno-octulosonate cytidylyltransferase DNO_0304 137 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 146329674 Common pilV hypothetical protein DNO_0894 4 COG4967 PilV, Tfp pilus assembly protein PilV Cell motility and secretion / Intracellular trafficking and secretion 146329064 Common ubiA 4-hydroxybenzoate polyprenyltransferase DNO_0397 137 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 146329246 Common relA GTP pyrophosphokinase DNO_0017 205 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 146329182 Common dcd deoxycytidine triphosphate deaminase DNO_0507 150 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 146329386 Common dtd D-tyrosyl-tRNA deacylase DNO_0491 139 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 146329187 Common - hypothetical protein DNO_0089 49 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 146329447 Pathogen - hypothetical lipoprotein DNO_1016 3 None None None 146328959 Common dnaA chromosomal replication initiator protein DNO_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 146329336 Common - 5-formyltetrahydrofolate cyclo-ligase family protein DNO_1201 161 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 146329226 Common rnfA electron transport complex protein, A subunit DNO_0555 76 COG4657 RnfA, Predicted NADH:ubiquinone oxidoreductase, subunit RnfA Energy production and conversion 146329277 Common hslV ATP-dependent protease peptidase subunit DNO_1346 149 COG5405 HslV, ATP-dependent protease HslVU (ClpYQ), peptidase subunit Posttranslational modification, protein turnover, chaperones 146328659 Pathogen - hypothetical protein DNO_1168 1 None None None 146329822 Common hslU ATP-dependent protease ATP-binding subunit DNO_1347 210 COG1220 HslU, ATP-dependent protease HslVU (ClpYQ), ATPase subunit Posttranslational modification, protein turnover, chaperones 146329601 Common recG ATP-dependent DNA helicase RecG DNO_1018 214 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 146328793 Common - RNA recognition motif protein DNO_0446 66 COG0724 COG0724, RNA-binding proteins (RRM domain) General function prediction only 146328680 Common - alkyl hydroperoxide reductase/thiol specific antioxidant family protein DNO_0557 226 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 146329194 Common ligA DNA ligase, NAD-dependent DNO_0389 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 146328866 Common rpmC 50S ribosomal protein L29 DNO_1267 112 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 146328995 Common ruvA holliday junction DNA helicase RuvA DNO_1177 209 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 146328895 Common - phage terminase, large subunit DNO_0743 25 COG1783 XtmB, Phage terminase large subunit General function prediction only 146329111 Common - hypothetical protein DNO_1300 13 COG2916 Hns, DNA-binding protein H-NS General function prediction only 146329736 Common nrdA ribonucleotide-diphosphate reductase subunit alpha DNO_0607 216 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 146329219 Common aprV5 acidic extracellular subtilisin-like protease precursor AprV5 DNO_0603 137 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 146328713 Pathogen - hypothetical protein DNO_0535 1 COG3117 COG3117, Uncharacterized protein conserved in bacteria Function unknown 146329909 Common - type 4 fimbrial biogenesis protein DNO_0515 20 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 146329207 Common rpsU 30S ribosomal protein S21 DNO_1081 146 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 146328938 Common accB acetyl-CoA carboxylase, biotin carboxyl carrier protein DNO_0420 187 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 146329210 Common tldD TldD protein DNO_0577 170 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 146329440 Common - 1-phosphofructokinase DNO_0583 119 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 146328846 Common - hypothetical protein DNO_0858 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 146329023 Common vrlE conserved hypothetical protein VrlE DNO_0187 15 None None None 146329483 Common deoD purine nucleoside phosphorylase DNO_0699 90 COG0813 DeoD, Purine-nucleoside phosphorylase Nucleotide transport and metabolism 146328663 Common recN DNA repair protein RecN DNO_1063 198 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 146329130 Common pyrC dihydroorotase DNO_0657 96 COG0418 PyrC, Dihydroorotase Nucleotide transport and metabolism 146329162 Pathogen - hypothetical protein DNO_0988 1 COG3116 FtsL, Cell division protein Cell division and chromosome partitioning 146328678 Common hemN-2 oxygen-independent coproporphyrinogen III oxidase HemN DNO_0131 205 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 146328953 Common - NLP-P60 family domain protein DNO_0036 115 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 146329053 Common rpsH 30S ribosomal protein S8 DNO_1261 243 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 146329072 Common - ATP-dependent rna helicase Rhl DNO_0865 230 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 146328755 Common csy2 hypothetical protein DNO_0168 18 None None None 146328687 Common - alpha-beta fold family protein DNO_0125 71 COG0429 COG0429, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 146329307 Common - conserved hypothetical lipoprotein DNO_1170 39 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 146329829 Common rplD 50S ribosomal protein L4 DNO_1274 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 146329501 Common rplP 50S ribosomal protein L16 DNO_1268 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 146329861 Common nagA N-acetylglucosamine-6-phosphate deacetylase DNO_0309 118 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 146329415 Common accD acetyl-CoA carboxylase, carboxyl transferase, beta subunit DNO_0405 218 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 146329873 Common secF preprotein translocase, SecF subunit DNO_0038 206 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 146329536 Common - short chain dehydrogenase family protein DNO_0923 155 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 146328672 Common - FAD dependent oxidoreductase superfamily DNO_0096 8 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 146329407 Common - hypothetical protein DNO_0009 58 COG2985 COG2985, Predicted permease General function prediction only 146328719 Pathogen - hypothetical protein DNO_0761 1 None None None 146328989 Common - glycosyl transferase family 8 protein DNO_0559 33 COG1442 RfaJ, Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases Cell envelope biogenesis, outer membrane 146328770 Common - hypothetical protein DNO_0221 9 None None None 146329404 Common - short chain dehydrogenase family DNO_0503 237 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 146328871 Common miaA tRNA delta(2)-isopentenylpyrophosphate transferase DNO_1117 214 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 146329431 Common ssb-2 single-strand binding protein DNO_0767 214 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 146328787 Common - hypothetical protein DNO_0591 6 COG2900 SlyX, Uncharacterized protein conserved in bacteria Function unknown 146329150 Pathogen - hypothetical protein DNO_0774 1 None None None 146329315 Common rpmF 50S ribosomal protein L32 DNO_1205 95 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 146329892 Common rplL 50S ribosomal protein L7/L12 DNO_1283 213 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 146328937 Common prfB peptide chain release factor 2 DNO_0939 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 146328660 Common - ABC transporter family ATP-binding protein DNO_0730 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 146329635 Common - acyltransferase domain protein DNO_0003 133 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 146329603 Pathogen - hypothetical protein DNO_1133 1 None None None 146328705 Common map methionine aminopeptidase, type I DNO_0724 240 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 146329024 Common - 7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase, HPPK DNO_0117 200 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 146329046 Common - hydrolase, HAD-superfamily DNO_1059 112 COG0241 HisB, Histidinol phosphatase and related phosphatases Amino acid transport and metabolism 146328837 Common - ADP-ribose pyrophosphatase DNO_0957 105 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 146328974 Pathogen - lipoprotein, putative DNO_0632 1 None None None 146329310 Common - BolA family protein DNO_0854 48 COG5007 COG5007, Predicted transcriptional regulator, BolA superfamily Transcription 146329381 Common coaD pantetheine-phosphate adenylyltransferase DNO_1005 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 146329721 Common secB protein export chaperone SecB DNO_0292 107 COG1952 SecB, Preprotein translocase subunit SecB Intracellular trafficking and secretion 146328917 Common - haloacid dehalogenase-like hydrolase family protein DNO_0437 143 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 146329196 Common pgl 6-phosphogluconolactonase DNO_1222 114 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 146328906 Common - hypothetical protein DNO_0388 31 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 146329008 Pathogen - hypothetical protein DNO_0374 1 None None None 146328828 Common - xanthine/uracil permease family protein DNO_0728 135 COG2252 COG2252, Permeases General function prediction only 146328860 Common - flavodoxin family protein DNO_0458 35 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 146329123 Common - Carbon starvation protein CstA family DNO_0132 109 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 146329348 Common - hypothetical protein DNO_0140 72 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 146329169 Common - hypothetical protein DNO_1061 45 COG1444 COG1444, Predicted P-loop ATPase fused to an acetyltransferase General function prediction only 146328697 Common rluD ribosomal large subunit pseudouridine synthase, RluD DNO_1311 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 146329628 Common ndh NADH dehydrogenase DNO_0618 174 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 146329562 Common - transposase IS200-like protein DNO_0386 66 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 146328961 Common tgt queuine tRNA-ribosyltransferase DNO_0319 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 146329054 Common fimP type IV prepilin peptidase DNO_1124 131 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 146329781 Common dgt deoxyguanosinetriphosphate triphosphohydrolase DNO_0254 159 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 146328652 Common - hypothetical protein DNO_0107 32 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 146328634 Common rnhB ribonuclease HII DNO_0687 231 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 146329621 Common - bacterial extracellular solute-binding family protein DNO_0502 181 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 146329254 Common rpoH RNA polymerase sigma-32 factor DNO_0876 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 146329238 Common pilU twitching motility protein PilU DNO_0676 208 COG5008 PilU, Tfp pilus assembly protein, ATPase PilU Cell motility and secretion / Intracellular trafficking and secretion 146328742 Common - 23S rRNA methyltransferase DNO_1083 198 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 146328724 Common hrpA ATP-dependent helicase HrpA DNO_0622 131 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 146329073 Common trmH RNA methyltransferase, TrmH family, group 3 DNO_0602 215 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 146329763 Common - bacterial solute binding family protein DNO_0123 41 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 146329387 Common dcuC C4-dicarboxylate anaerobic carrier DNO_0931 43 COG1288 COG1288, Predicted membrane protein Function unknown 146329369 Pathogen - conserved hypothetical lipoprotein DNO_0194 1 COG3134 COG3134, Predicted outer membrane lipoprotein Function unknown 146328885 Common telA toxic anion resistance protein DNO_0637 30 COG3853 TelA, Uncharacterized protein involved in tellurite resistance Inorganic ion transport and metabolism 146329858 Common - hypothetical protein DNO_0075 77 COG0730 COG0730, Predicted permeases General function prediction only 146328669 Common - Leucine Rich Repeat domain protein DNO_0007 48 COG4886 COG4886, Leucine-rich repeat (LRR) protein Function unknown 146329792 Common ftsH ATP-dependent protease FtsH DNO_1238 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 146329142 Common intB2 integrase B2 DNO_1038 69 None None None 146328777 Common - glycerol-3-phosphate dehydrogenase DNO_0293 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 146328878 Pathogen - hypothetical protein DNO_0770 1 None None None 146329295 Common rluA ribosomal large subunit pseudouridine synthase, RluA DNO_0294 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 146329371 Common - zinc uptake system protein DNO_0354 168 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 146329568 Common dnaQ DNA polymerase III, epsilon subunit DNO_0906 183 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 146329578 Common - Sua5-YciO-YrdC-YwlC domain protein DNO_0237 175 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 146329378 Pathogen - hypothetical protein DNO_1242 1 None None None 146329362 Common rho transcription termination factor Rho DNO_0736 203 COG1158 Rho, Transcription termination factor Transcription 146328714 Common - hypothetical protein DNO_0148 13 None None None 146329735 Common guaB inosine-5'-monophosphate dehydrogenase DNO_0376 241 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 146329521 Common - conserved hypothetical lipoprotein DNO_1327 11 COG3784 COG3784, Uncharacterized protein conserved in bacteria Function unknown 146329516 Common purC phosphoribosylaminoimidazole-succinocarboxamidesynthase DNO_1112 179 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 146329709 Common hsdS type I restriction modification DNA specificity domain protein DNO_0222 105 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 146329806 Pathogen - hypothetical protein DNO_0746 1 None None None 146329170 Common - NUDIX hydrolase domain protein DNO_0658 112 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 146328890 Common rpsL 30S ribosomal protein S12 DNO_1280 233 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 146328700 Common menA 1,4-dihydroxy-2-naphthoate octaprenyltransferase DNO_0709 67 COG1575 MenA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase Coenzyme metabolism 146328946 Common - modification methylase, HemK family DNO_0072 219 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 146329817 Common - ABC transporter domain protein DNO_0364 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 146329211 Common - ATP-NAD kinase DNO_1062 238 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 146329771 Pathogen - hypothetical protein DNO_0085 1 None None None 146329159 Common pilS two-componenent sensor PilS DNO_0434 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 146329711 Common - conserved hypothetical lipoprotein DNO_0700 16 COG3015 CutF, Uncharacterized lipoprotein NlpE involved in copper resistance Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism 146328899 Common - hypothetical protein DNO_1067 148 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 146329901 Common purF amidophosphoribosyltransferase DNO_0088 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 146329116 Common groES co-chaperonin GroES DNO_1340 216 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 146328922 Common pflB pyruvate-formate lyase DNO_1334 59 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 146329604 Common rplE 50S ribosomal protein L5 DNO_1263 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 146329652 Common fabF 3-oxoacyl-(acyl-carrier-protein) synthase II DNO_1211 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 146329611 Common - L-asparaginase II DNO_0393 131 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 146328940 Common - hypothetical lipoprotein DNO_1241 2 None None None 146328753 Common - hypothetical lipoprotein DNO_0128 35 COG3034 COG3034, Uncharacterized protein conserved in bacteria Function unknown 146328967 Common aroE shhikimate 5-dehydrogenase DNO_0509 160 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 146328640 Common - hypothetical protein DNO_0426 217 COG4536 CorB, Putative Mg2+ and Co2+ transporter CorB Inorganic ion transport and metabolism 146328689 Common atpB F0F1 ATP synthase subunit A DNO_1148 181 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 146328853 Common gyrB DNA gyrase, B subunit DNO_0612 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 146329692 Common degQ serine protease DNO_0902 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 146329027 Common fbp fructose-1,6-bisphosphatase DNO_0468 108 COG0158 Fbp, Fructose-1,6-bisphosphatase Carbohydrate transport and metabolism 146329559 Common vrlD conserved hypothetical protein VrlD DNO_0188 3 None None None 146328897 Common - methylenetetrahydrofolate reductase family protein DNO_1022 35 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 146329860 Common pstS phosphate binding family protein DNO_1180 136 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 146329410 Pathogen - hypothetical protein DNO_0308 1 COG4714 COG4714, Uncharacterized membrane-anchored protein conserved in bacteria Function unknown 146328682 Common rpiA ribose 5-phosphate isomerase DNO_0522 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 146329002 Common - hypothetical protein DNO_0567 19 COG3103 COG3103, SH3 domain protein Signal transduction mechanisms 146329875 Common - lipid A biosynthesis lauroyl acyltransferase DNO_0998 100 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 146329368 Common prsA ribose-phosphate pyrophosphokinase DNO_0065 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 146329427 Common - hypothetical protein DNO_0412 91 COG0701 COG0701, Predicted permeases General function prediction only 146329582 Common comL competence protein ComL DNO_1310 127 COG4105 ComL, DNA uptake lipoprotein General function prediction only 146329877 Common lpdA dihydrolipoamide dehydrogenase DNO_1100 238 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 146329397 Common metK S-adenosylmethionine synthetase DNO_0971 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 146328947 Common - oligopeptide transport protein DNO_0452 209 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 146329201 Common glyA serine hydroxymethyltransferase DNO_0476 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 146328862 Pathogen - hypothetical protein DNO_1188 1 None None None 146329081 Common - response regulator receiver domain protein-DNA repair protein RadC DNO_0822 220 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 146329591 Common - hypothetical protein DNO_0937 94 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 146329132 Common dsbD thiol:disulfide interchange protein DsbD DNO_0418 98 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 146329107 Common rpsT 30S ribosomal protein S20 DNO_1025 208 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 146328796 Pathogen - hypothetical protein DNO_0357 1 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 146329868 Pathogen - hypothetical protein DNO_0742 2 None None None 146329618 Common pyrG CTP synthetase DNO_0360 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 146328950 Common - two component phosphate response regulator PhoB DNO_0903 220 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 146328980 Common - MarR family transcriptional regulator DNO_0788 7 COG1846 MarR, Transcriptional regulators Transcription 146328916 Common - hypothetical protein DNO_0717 7 COG3079 COG3079, Uncharacterized protein conserved in bacteria Function unknown 146329471 Common - hypothetical protein DNO_0218 18 COG2958 COG2958, Uncharacterized protein conserved in bacteria Function unknown 146329481 Common mutL DNA mismatch repair protein MutL DNO_1116 191 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 146328821 Common - phosphoglycerate mutase family protein DNO_1344 23 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 146328957 Common - MarC family membrane protein DNO_0849 156 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 146329279 Common - nitroreductase family protein DNO_0866 89 COG0778 NfnB, Nitroreductase Energy production and conversion 146329506 Common nhaA Na+-H+ antiporter NhaA DNO_0816 106 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 146329184 Pathogen - hypothetical protein DNO_0896 1 None None None 146329514 Common xerD tyrosine recombinase XerD DNO_1131 227 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 146328648 Common - recombination factor protein RarA DNO_0485 217 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 146329645 Common polA DNA polymerase I DNO_0206 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 146329309 Pathogen - hypothetical lipoprotein DNO_0623 1 None None None 146329342 Pathogen - hypothetical protein DNO_0996 1 None None None 146329010 Common ribB 3,4-dihydroxy-2-butanone 4-phosphate synthase DNO_0472 229 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 146329466 Common rpoZ DNA-directed RNA polymerase, omega subunit DNO_1021 114 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 146329889 Common - outer membrane protein DNO_0681 159 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 146329413 Common - enoyl-[acyl-carrier-protein] reductase DNO_0074 231 COG0623 FabI, Enoyl- acyl-carrier-protein 146329240 Common ptrB prolyl oligopeptidase DNO_1338 100 COG1770 PtrB, Protease II Amino acid transport and metabolism 146329252 Common rdgB Ham1-like protein DNO_0663 237 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 146329664 Common - two-component phosphate sensor PhoR DNO_0819 220 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 146329067 Common - OmpA family protein DNO_0333 169 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 146329788 Common aspS aspartyl-tRNA synthetase DNO_1118 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146329288 Pathogen - hypothetical lipoprotein DNO_1155 1 None None None 146329333 Common - hypothetical protein DNO_0438 51 COG3536 COG3536, Uncharacterized protein conserved in bacteria Function unknown 146328764 Pathogen vrlM hypothetical protein VrlM DNO_0179 1 None None None 146329013 Common - hypothetical protein DNO_0704 23 COG2731 EbgC, Beta-galactosidase, beta subunit Carbohydrate transport and metabolism 146329753 Pathogen - hypothetical protein DNO_0216 1 None None None 146329459 Common - ABC transporter family ATP-binding protein DNO_0859 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 146329681 Common anmK anhydro-N-acetylmuramic acid kinase DNO_1323 120 COG2377 COG2377, Predicted molecular chaperone distantly related to HSP70-fold metalloproteases Posttranslational modification, protein turnover, chaperones 146329038 Common - macrolide-specific ABC-type efflux carrier protein DNO_0872 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 146329700 Common - aminoacyl-histidine dipeptidase DNO_0049 52 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 146329300 Common glmS glucosamine-fructose-6-phosphate aminotransferase DNO_0528 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 146328933 Common - MarR family transcriptional regulator DNO_0151 144 COG1846 MarR, Transcriptional regulators Transcription 146328779 Pathogen - hypothetical protein DNO_0892 1 COG4726 PilX, Tfp pilus assembly protein PilX Cell motility and secretion / Intracellular trafficking and secretion 146329452 Common rluE ribosomal large subunit pseudouridine synthase, RluE DNO_0584 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 146329643 Common - phospholipase/carboxylesterase family protein DNO_0714 88 COG0400 COG0400, Predicted esterase General function prediction only 146328803 Common tolA TolA protein DNO_1173 3 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 146329088 Common prfA peptide chain release factor 1 DNO_0071 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 146329099 Common clpA ATP-dependent Clp protease ATP-binding subunit ClpA DNO_0655 223 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 146329223 Common - hypothetical protein DNO_0576 178 COG1159 Era, GTPase General function prediction only 146328912 Pathogen - hypothetical protein DNO_0740 1 None None None 146328904 Common trmD tRNA (guanine-N1-)-methyltransferase DNO_1009 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 146329713 Common infB translation initiation factor IF-2 DNO_0029 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 146329672 Common rpmD 50S ribosomal protein L30 DNO_1257 120 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 146329723 Common ribF riboflavin kinase RibF DNO_0082 211 COG0196 RibF, FAD synthase Coenzyme metabolism 146328919 Common - hypothetical protein DNO_1153 85 COG0795 COG0795, Predicted permeases General function prediction only 146329623 Common pilG twitching motility regulator PilG DNO_1097 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 146329409 Common - pseudouridine synthase, TruD family DNO_1134 76 COG0585 COG0585, Uncharacterized conserved protein Function unknown 146329783 Common ntrY histidine kinase, NtrY DNO_0160 212 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 146329564 Common - hypothetical protein DNO_0050 7 None None None 146329778 Common - MoxR family protein DNO_0842 171 COG0714 COG0714, MoxR-like ATPases General function prediction only 146329157 Common apaH diadenosine tetraphosphatase DNO_1294 105 None None None 146329462 Common - GHMP kinase family protein DNO_0800 5 COG1577 ERG12, Mevalonate kinase Lipid metabolism 146329256 Common rplC 50S ribosomal protein L3 DNO_1275 226 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 146329836 Common pnp polynucleotide phosphorylase/polyadenylase DNO_1047 243 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 146329450 Common - alkyl hydroperoxide reductase, F subunit DNO_0144 249 COG3634 AhpF, Alkyl hydroperoxide reductase, large subunit Posttranslational modification, protein turnover, chaperones 146329824 Common coaBC phosphopantothenoylcysteine decarboxylase/phosphopantothenate-cysteine ligase DNO_0823 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 146328869 Common - bacterial extracellular solute-binding family protein DNO_0034 167 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 146328636 Common - hypothetical protein DNO_0775 16 None None None 146328733 Pathogen vrlN hypothetical protein VrlN DNO_0178 1 None None None 146329163 Common prfC peptide chain release factor 3 DNO_0501 249 COG4108 PrfC, Peptide chain release factor RF-3 Translation, ribosomal structure and biogenesis 146328695 Common - LolA family outer membrane lipoprotein carrier protein DNO_0484 62 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 146328978 Common vapE2 virulence-associated protein VapE2 DNO_0266 32 COG5545 COG5545, Predicted P-loop ATPase and inactivated derivatives General function prediction only 146329546 Common - nucleotidyl transferase family protein DNO_0513 212 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 146329469 Common - GHMP kinase family protein DNO_0489 15 COG1577 ERG12, Mevalonate kinase Lipid metabolism 146328883 Common folB dihydroneopterin aldolase DNO_1076 102 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 146329512 Common - AmpG family permaese DNO_1314 103 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 146328944 Common cdsA phosphatidate cytidylyltransferase DNO_0718 215 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 146328780 Common pfs MTA-SAH nucleosidase DNO_0624 90 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 146329845 Common - NAD-dependent deacetylase, Sir2 family DNO_1032 152 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 146328971 Common vrlR hypothetical protein VrlR DNO_0174 2 None None None 146329149 Pathogen - lipoprotein, putative DNO_0997 1 None None None 146329156 Common - conserved hypothetical lipoprotein DNO_0370 57 COG3045 CreA, Uncharacterized protein conserved in bacteria Function unknown 146329457 Common - peptidylprolyl cis-trans isomerase, cyclophilin- type DNO_0209 199 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 146329052 Common phoU phosphate uptake regulator PhoU DNO_1066 177 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 146329856 Common vrlP conserved hypothetical protein VrlP DNO_0176 11 None None None 146329086 Common deoA thymidine phosphorylase DNO_0908 126 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 146329133 Common fabB beta-ketoacyl synthase DNO_0315 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 146329349 Common - glutamine amidotransferase DNO_0653 114 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 146328675 Common pilJ twitching motility protein PilJ DNO_1094 154 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 146328876 Common vapA1 virulence-associated protein VapA1 DNO_0275 64 COG3093 VapI, Plasmid maintenance system antidote protein General function prediction only 146329810 Common rpsD 30S ribosomal protein S4 DNO_1252 228 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 146329118 Common rpoC DNA-directed RNA polymerase, beta' subunit DNO_1281 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 146329176 Common - hypothetical protein DNO_0146 32 COG2229 COG2229, Predicted GTPase General function prediction only 146329140 Common rplX 50S ribosomal protein L24 DNO_1264 210 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 146328781 Common - hypothetical protein DNO_0295 100 COG0628 PerM, Predicted permease General function prediction only 146328747 Common rluC ribosomal large subunit pseudouridine synthase, RluC DNO_1001 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 146328712 Common - AsnC family transcriptional regulator DNO_0469 155 COG1522 Lrp, Transcriptional regulators Transcription 146329364 Common lepA GTP-binding protein LepA DNO_0694 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 146329213 Common rrmJ 23S rRNA methyltransferase DNO_1239 138 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 146329743 Common mgtE magnesium transporter DNO_0796 170 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 146328939 Common - hypothetical protein DNO_1248 78 COG1469 COG1469, Uncharacterized conserved protein Function unknown 146329069 Common rnfC electron transport complex protein, C subunit DNO_0553 73 COG4656 RnfC, Predicted NADH:ubiquinone oxidoreductase, subunit RnfC Energy production and conversion 146329606 Common recB exonuclease V, beta subunit DNO_1165 208 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 146329812 Common - hypothetical protein DNO_0575 26 COG0218 COG0218, Predicted GTPase General function prediction only 146329120 Common ampD N-acetyl-anhydromuranmyl-L-alanine amidase DNO_1202 100 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 146328766 Common - hypothetical protein DNO_0343 186 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 146329224 Common plsX fatty acid-phospholipid synthesis protein PlsX DNO_1206 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 146329819 Common yccS membrane protein DNO_0004 53 COG1289 COG1289, Predicted membrane protein Function unknown 146328707 Common dam DNA adenine methylase DNO_1161 94 COG0338 Dam, Site-specific DNA methylase DNA replication, recombination, and repair 146329794 Common - 4'-phosphopantetheinyl transferase superfamily domain protein DNO_0905 7 COG2091 Sfp, Phosphopantetheinyl transferase Coenzyme metabolism 146328969 Common gidA tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA DNO_0672 191 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 146329443 Common - zinc uptake system ATP-binding protein DNO_0355 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 146329231 Pathogen - hypothetical protein DNO_0747 1 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146329070 Common fabZ beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ DNO_0684 186 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 146329059 Common gshB glutathione synthetase DNO_1218 126 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 146329533 Common - peptidase M20 family DNO_0697 176 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 146329765 Common lpxD UDP-3-O-[3-hydroxymyristoyl] glucosamine N- acyltransferase DNO_0683 155 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 146329589 Common - tripeptide permease family protein DNO_1186 74 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 146329044 Common dusA tRNA-dihydrouridine synthase A DNO_1052 202 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 146329796 Pathogen - hypothetical protein DNO_0262 1 None None None 146329354 Common - hypothetical protein DNO_0427 13 COG4137 COG4137, ABC-type uncharacterized transport system, permease component General function prediction only 146329498 Common upp uracil phosphoribosyltransferase DNO_0586 164 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 146328720 Common - conserved hypothetical lipoprotein DNO_0556 14 None None None 146329373 Common - sulfate transporter family protein DNO_0104 145 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 146329313 Pathogen - hypothetical lipoprotein DNO_0462 1 None None None 146328727 Common nqrA Na(+)-translocating NADH-quinone reductase subunit A DNO_0811 39 COG1726 NqrA, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA Energy production and conversion 146329495 Common - hypothetical protein DNO_1158 53 COG3169 COG3169, Uncharacterized protein conserved in bacteria Function unknown 146328722 Common pilQ type IV fimbrial pore PilQ DNO_0348 140 COG4796 HofQ, Type II secretory pathway, component HofQ Intracellular trafficking and secretion 146329729 Common dsbG protein disulfide isomerase DNO_0924 66 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 146328874 Common rpsS 30S ribosomal protein S19 DNO_1271 247 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 146328807 Common - hypothetical protein DNO_0219 146 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 146328815 Common - hypothetical lipoprotein DNO_0407 2 COG5510 COG5510, Predicted small secreted protein Function unknown 146329190 Common argF-1 ornithine carbamoyltransferase DNO_1074 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 146328851 Common - preprotein translocase subunit YidC DNO_0949 213 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 146329733 Common - hypothetical protein DNO_0739 35 COG3926 zliS, Putative secretion activating protein General function prediction only 146329270 Common rpsK 30S ribosomal protein S11 DNO_1253 248 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 146329593 Common pstB ABC-type phosphate transporter ATP-binding protein DNO_1183 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 146329374 Common - adenine nucleotide alpha hydrolase ATP-binding family protein DNO_1088 161 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 146329298 Common gltX glutamyl-tRNA synthetase DNO_0734 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 146329639 Pathogen - hypothetical protein DNO_0956 1 COG5281 COG5281, Phage-related minor tail protein Function unknown 146329109 Common - exopolyphosphatase DNO_0369 174 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 146328798 Common aroA 3-phosphoshikimate 1-carboxyvinyltransferase DNO_0111 229 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 146329647 Common hflC HflC protein DNO_0598 186 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 146328991 Common - hypothetical protein DNO_0433 205 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 146329221 Common - colicin V family protein CvpA DNO_0402 65 COG1286 CvpA, Uncharacterized membrane protein, required for colicin V production General function prediction only 146328751 Common - thiamine pyrophosphokinase family protein DNO_0090 11 COG1564 THI80, Thiamine pyrophosphokinase Coenzyme metabolism 146329650 Common - thiamine biosynthesis lipoprotein ApbE DNO_0805 141 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 146328858 Common - stringent starvation protein A DNO_0851 91 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 146329030 Common hemN-1 oxygen-independent coproporphyrinogen III oxidase DNO_0087 203 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 146329613 Common - hypothetical protein DNO_0153 35 COG2922 Smg, Uncharacterized protein conserved in bacteria Function unknown 146329659 Common clpS ATP-dependent Clp protease adaptor protein ClpS DNO_0656 119 COG2127 COG2127, Uncharacterized conserved protein Function unknown 146328909 Common pepT-2 peptidase T DNO_1350 61 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 146329690 Common - phosphoesterase domain protein DNO_0925 23 COG4186 COG4186, Predicted phosphoesterase or phosphohydrolase General function prediction only 146329020 Common - hypothetical protein DNO_0464 176 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 146329870 Common iscS cysteine desulfurase DNO_1196 238 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 146329808 Common csy3 hypothetical protein DNO_0169 21 None None None 146329203 Pathogen - hypothetical protein DNO_1154 1 None None None 146329419 Common rplR 50S ribosomal protein L18 DNO_1259 217 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 146329751 Pathogen - hypothetical lipoprotein DNO_0460 1 None None None 146329569 Common - hypothetical protein DNO_1014 18 COG5342 COG5342, Invasion protein B, involved in pathogenesis General function prediction only 146328630 Common alr alanine racemase DNO_0325 199 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 146329433 Common - Bacterial extracellular solute-binding protein DNO_1343 98 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 146329821 Common - response regulator receiver domain protein DNO_0138 2 None None None 146329831 Common - haloacid dehalogenase-like hydrolase, COF family DNO_0120 107 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 146329579 Common - hypothetical protein DNO_0289 37 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 146329015 Common - hypothetical protein DNO_0243 14 None None None 146329100 Common - rare lipoprotein A domain protein DNO_0961 136 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 146328642 Common recO hypothetical protein DNO_1128 9 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 146329572 Common - TetR family transcriptional regulator DNO_1189 67 COG1309 AcrR, Transcriptional regulator Transcription 146328998 Common rplT 50S ribosomal protein L20 DNO_0524 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 146329637 Common - Xanthine/uracil permease family protein DNO_0662 124 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 146328935 Common sucD succinyl-CoA synthetase, alpha subunit DNO_1313 217 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 146329758 Pathogen - hypothetical protein DNO_0790 1 None None None 146329036 Common - hypothetical protein DNO_0332 35 COG3216 COG3216, Uncharacterized protein conserved in bacteria Function unknown 146329324 Common rpmA 50S ribosomal protein L27 DNO_0487 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 146329688 Common - ComEA-related protein DNO_0882 115 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 146329880 Common - outer membrane protein DNO_0861 118 COG0729 COG0729, Outer membrane protein Cell envelope biogenesis, outer membrane 146329508 Common rnfD electron transport complex protein, D subunit DNO_0552 76 COG4658 RnfD, Predicted NADH:ubiquinone oxidoreductase, subunit RnfD Energy production and conversion 146329135 Common glnS glutaminyl-tRNA synthetase DNO_1108 242 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 146329094 Common pgk phosphoglycerate kinase DNO_1036 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 146328769 Common fimA fimbrial subunit FimA DNO_0110 63 COG4969 PilA, Tfp pilus assembly protein, major pilin PilA Cell motility and secretion / Intracellular trafficking and secretion 146329478 Common gatA glutamyl-tRNA(Gln) amidotransferase, A subunit DNO_0969 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 146329079 Common - hypothetical protein DNO_0588 3 None None None 146329707 Common acrF mutidrug efflux protein DNO_1191 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 146328910 Common gatC glutamyl-tRNA(Gln) amidotransferase, C subunit DNO_0968 11 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 146329097 Common mfd transcription-repair coupling factor DNO_0689 225 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 146329558 Common - hypothetical protein DNO_0035 44 COG2949 SanA, Uncharacterized membrane protein Function unknown 146329060 Common - hypothetical protein DNO_0051 132 COG2860 COG2860, Predicted membrane protein Function unknown 146329395 Common vapB2 virulence-associated protein VapB2 DNO_1041 21 COG4456 VagC, Virulence-associated protein and related proteins Function unknown 146329838 Common - hypothetical lipoprotein DNO_0067 6 COG3017 LolB, Outer membrane lipoprotein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 146328805 Pathogen - hypothetical protein DNO_0052 1 None None None 146329355 Common - hypothetical protein DNO_0500 8 None None None 146329186 Common - hypothetical protein DNO_0322 53 COG3152 COG3152, Predicted membrane protein Function unknown 146329287 Common sufC FeS assembly ATPase SufC DNO_0836 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 146328839 Common - ABC transporter family ATP-binding protein DNO_0970 247 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 146329670 Common - hypothetical protein DNO_0754 4 None None None 146329657 Common - hypothetical protein DNO_0950 183 COG0759 COG0759, Uncharacterized conserved protein Function unknown 146328844 Common zur zinc uptake regulation protein DNO_0707 107 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 146328823 Common ntrX response regulator, NtrX DNO_0161 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 146329242 Common - ribonuclease R DNO_0601 199 COG0557 VacB, Exoribonuclease R Transcription 146329596 Common rsmB rRNA SAM-dependent methyltransferase, Fmu DNO_0158 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 146328982 Common gepB hypothetical protein DNO_0259 58 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 146329344 Common purD phosphoribosylglycinamide synthetase DNO_0940 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 146329057 Common - ThiF family domain protein DNO_0416 223 COG1179 COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Coenzyme metabolism 146329894 Common - hypothetical protein DNO_0521 20 COG5505 COG5505, Predicted integral membrane protein Function unknown 146329004 Common ppk polyphosphate kinase DNO_1106 162 COG0855 Ppk, Polyphosphate kinase Inorganic ion transport and metabolism 146329383 Common - voltage-gated chloride channel protein DNO_0396 159 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 146329464 Common xerC site-specific recombinase XerC DNO_0041 222 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 146329475 Common - TPR domain protein DNO_0571 5 None None None 146329748 Common nusA transcription termination factor DNO_0030 217 COG0195 NusA, Transcription elongation factor Transcription 146329331 Common ackA acetate kinase DNO_0447 161 COG0282 ackA, Acetate kinase Energy production and conversion 146329648 Common tkt transketolase DNO_1035 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 146328873 Common - trypsin-like serine and cysteine protease family protein DNO_1320 206 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 146329337 Common - hypothetical protein DNO_0342 38 COG4764 COG4764, Uncharacterized protein conserved in bacteria Function unknown 146329654 Common topA DNA topoisomerase I DNO_0152 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 146328822 Pathogen - hypothetical protein DNO_1050 1 COG3087 FtsN, Cell division protein Cell division and chromosome partitioning 146329274 Common - glutamate racemase DNO_0005 190 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 146329261 Common aroK shikimate kinase I DNO_0611 199 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 146329085 Pathogen - hypothetical lipoprotein DNO_0401 1 None None None 146329299 Common pdxK pyridoxal kinase DNO_0929 83 COG2240 PdxK, Pyridoxal/pyridoxine/pyridoxamine kinase Coenzyme metabolism 146329509 Common - ABC transporter domain protein DNO_0336 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 146328859 Common - Gram-negative porin family protein DNO_0495 44 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 146329732 Common ilvA threonine dehydratase DNO_0323 215 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 146329233 Common metF 5,10-methylenetetrahydrofolate reductase DNO_0863 144 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 146328746 Common dcuCA C4-dicarboxylate anaerobic carrier, DcuC family protein DNO_1353 20 COG3069 DcuC, C4-dicarboxylate transporter Energy production and conversion 146328832 Common - hypothetical protein DNO_0539 2 None None None 146328690 Common - hypothetical protein DNO_0673 16 None None None 146329327 Common pyrD dihydroorotate dehydrogenase DNO_0669 187 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 146329245 Common - D-alanine-D-alanine ligase DNO_0979 211 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 146328986 Common - Rrf2 family protein DNO_0838 117 COG1959 COG1959, Predicted transcriptional regulator Transcription 146329283 Common recF DNA replication and repair protein RecF DNO_0202 160 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 146329488 Pathogen - hypothetical protein DNO_1199 1 None None None 146329093 Pathogen - hypothetical protein DNO_0375 1 None None None 146329423 Pathogen - hypothetical protein DNO_0636 1 None None None 146329204 Common ribH 6,7-dimethyl-8-ribityllumazine synthase DNO_0471 230 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 146328645 Common - type IV fimbrial biogenesis protein DNO_0890 22 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 146329076 Common - hypothetical protein DNO_0832 138 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 146329553 Common rplO 50S ribosomal protein L15 DNO_1256 216 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 146329741 Common rpsP 30S ribosomal protein S16 DNO_1007 174 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 146328930 Common - bacterial extracellular solute-binding family protein DNO_0831 107 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 146329302 Common - patatin-like phospholipase family protein DNO_0802 18 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 146329663 Common rpsN 30S ribosomal protein S14 DNO_1262 209 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 146329090 Common - hypothetical protein DNO_0690 120 COG5665 NOT5, CCR4-NOT transcriptional regulation complex, NOT5 subunit Transcription 146329703 Common uvrB excinuclease ABC subunit B DNO_0558 228 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 146329061 Common - dihydrouridine synthase DNO_0423 208 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 146329537 Common pth peptidyl-tRNA hydrolase DNO_0063 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 146329304 Common - YhbY family protein DNO_1240 91 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 146329687 Pathogen - hypothetical protein DNO_1219 1 None None None 146328894 Common vapE3 virulence-associated protein VapE3 DNO_1043 32 COG5545 COG5545, Predicted P-loop ATPase and inactivated derivatives General function prediction only 146329548 Common - sec-independent protein translocase protein TatB DNO_0450 39 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 146328768 Common - transglutaminase family protein DNO_0839 91 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 146328683 Common hfq Hfq RNA-binding protein DNO_0595 127 COG1923 Hfq, Uncharacterized host factor I protein General function prediction only 146329879 Common - hypothetical protein DNO_0372 29 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 146328799 Common - ABC transporter domain protein DNO_0256 190 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 146329446 Common - lipoprotein DNO_0958 182 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 146329530 Common dnaB replicative DNA helicase DNO_0324 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 146329801 Common murF UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase DNO_0985 209 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 146329864 Pathogen - hypothetical protein DNO_1092 1 None None None 146328849 Common secE preprotein translocase, SecE subunit DNO_1288 12 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 146329435 Common arcA arginine deiminase DNO_1075 51 COG2235 ArcA, Arginine deiminase Amino acid transport and metabolism 146328701 Common recX RecX family regulatory protein DNO_0287 68 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 146329350 Common nqrB Na(+)-translocating NADH-quinone reductase subunit B DNO_0810 76 COG1805 NqrB, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB Energy production and conversion 146329016 Pathogen - hypothetical protein DNO_1139 1 None None None 146328923 Common - hypothetical protein DNO_0879 29 COG2979 COG2979, Uncharacterized protein conserved in bacteria Function unknown 146328867 Common lpxC UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase DNO_0975 139 COG0774 LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase Cell envelope biogenesis, outer membrane 146329823 Common - O-sialoglycoprotein endopeptidase DNO_0018 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 146329697 Common msrA-B methionine sulfoxide reductase MsrA-B DNO_0792 206 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 146328956 Common rpsB ribosomal protein S2 DNO_0723 228 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 146329290 Common - OstA-like family protein DNO_0534 35 COG1934 COG1934, Uncharacterized protein conserved in bacteria Function unknown 146328907 Common vapE1 virulence-associated protein VapE1 DNO_0279 32 COG5545 COG5545, Predicted P-loop ATPase and inactivated derivatives General function prediction only 146329595 Common rnc ribonuclease III DNO_0692 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 146329188 Common - bvg accessory factor family protein DNO_0542 134 COG1521 COG1521, Putative transcriptional regulator, homolog of Bvg accessory factor Transcription 146329161 Common galE UDP-glucose 4-epimerase DNO_0941 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 146328655 Common - helicase family protein DNO_0763 114 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 146329750 Common vapD2 virulence-associated protein VapD2 DNO_0265 7 COG3309 VapD, Uncharacterized virulence-associated protein D Function unknown 146329112 Common - Na+-H+ antiporter family protein DNO_0654 44 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 146329042 Common - ornithine decarboxylase, constitutive DNO_0014 82 COG1982 LdcC, Arginine/lysine/ornithine decarboxylases Amino acid transport and metabolism 146329414 Common - hypothetical protein DNO_1068 10 None None None 146328801 Common gph phosphoglycolate phosphatase DNO_0537 199 COG0546 Gph, Predicted phosphatases General function prediction only 146328808 Common secY preprotein translocase, SecY subunit DNO_1255 240 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 146329502 Common rplU 50S ribosomal protein L21 DNO_0486 213 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 146329049 Pathogen - hypothetical membrane protein DNO_1104 1 None None None 146329179 Pathogen vapF virulence-associated protein VapF DNO_0267 1 None None None 146329320 Common - hypothetical protein DNO_0310 15 COG3691 COG3691, Uncharacterized protein conserved in bacteria Function unknown 146329617 Common - hypothetical protein DNO_0238 64 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 146329757 Common pgpA phosphatidylglycerophosphatase A DNO_0668 97 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 146329493 Common cydB cytochrome bd ubiquinol oxidase, subunit II DNO_0099 156 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 146329228 Common dcpA peptidyl-dipeptidase I DNO_1351 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 146329058 Common - thioesterase family domain protein DNO_0574 23 COG0824 FcbC, Predicted thioesterase General function prediction only 146329264 Common recC Exodeoxyribonuclease V, gamma subunit DNO_0251 62 COG1330 RecC, Exonuclease V gamma subunit DNA replication, recombination, and repair 146329519 Common - aspartate kinase family protein DNO_0285 235 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 146329437 Pathogen - hypothetical protein DNO_0453 1 None None None 146329828 Common - phage tail tape measure family protein DNO_0755 40 COG5283 COG5283, Phage-related tail protein Function unknown 146329777 Common - hypothetical protein DNO_1082 116 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 146329312 Common pcnB poly(A) polymerase PcnB DNO_0116 213 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 146328761 Common - phosphoglycerate mutase DNO_0706 159 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 146329258 Common mraY phospho-N-acetylmuramoyl-pentapeptide-transferase DNO_0984 212 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 146328739 Common - penicillin-binding protein 1B DNO_0570 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 146329510 Common - hypothetical protein DNO_0031 141 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 146329848 Common dnaE DNA polymerase III, alpha subunit DNO_0688 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 146329389 Common - hypothetical protein DNO_0665 137 COG1561 COG1561, Uncharacterized stress-induced protein Function unknown 146328737 Common mutM formamidopyrimidine-DNA glycosylase DNO_1135 181 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 146329470 Common dnaJ chaperone protein DnaJ DNO_0827 235 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 146329531 Common hisS histidyl-tRNA synthetase DNO_0517 248 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146329417 Common ubiG ubiquinone biosynthesis O-methyltransferase DNO_0538 172 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 146328771 Common - manganese superoxide dismutase DNO_1348 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 146329549 Common znuA high-affinity zinc uptake system protein DNO_0889 153 COG4531 ZnuA, ABC-type Zn2+ transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 146329197 Common - endoribonuclease L-PSP DNO_1019 190 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 146329834 Common rng ribonuclease g DNO_0493 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 146328710 Pathogen - hypothetical lipoprotein DNO_1006 1 None None None 146329357 Common - Glutathione S-transferase DNO_0086 88 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 146328730 Pathogen - hypothetical protein DNO_0771 1 None None None 146329597 Common ribE riboflavin synthase subunit alpha DNO_0473 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 146328782 Common regA1 regulatory protein RegA1 DNO_0263 30 COG2932 COG2932, Predicted transcriptional regulator Transcription 146328966 Common dnaX DNA polymerase III, subunits gamma and tau DNO_0955 246 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 146329715 Common - peptidase family U34 protein DNO_0352 22 COG4690 PepD, Dipeptidase Amino acid transport and metabolism 146329590 Common - glycoprotease family protein DNO_0573 178 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 146329705 Common mutY A-G-specific adenine glycosylase DNO_0647 219 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 146329235 Common hemD uroporphyrinogen-III synthase family protein HemD DNO_0298 18 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 146328949 Common leuS leucyl-tRNA synthetase DNO_0246 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146329609 Pathogen - hypothetical lipoprotein DNO_0864 1 None None None 146328911 Common arcC carbamate kinase-like carbamoyl phosphate synthetase DNO_1073 65 COG0549 ArcC, Carbamate kinase Amino acid transport and metabolism 146329815 Common purK phosphoribosylaminoimidazole carboxylase, ATPase subunit DNO_0078 192 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 146328632 Common nrdR hypothetical protein DNO_0475 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 146329215 Common pilH twitching motility regulator PilH DNO_1096 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 146329119 Common dsbC thiol:disulfide interchange protein DsbC DNO_1317 64 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 146329854 Common hsdR type I site-specific deoxyribonuclease DNO_0220 136 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 146329730 Common - PTS system, fructose IIA component DNO_0703 21 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 146329571 Common rnhA RNase H DNO_1102 175 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 146329556 Common ftsK cell division protein, FtsK DNO_0483 199 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 146328667 Common - OmpA family protein DNO_0081 167 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 146329803 Common nqrD NADH:ubiquinone oxidoreductase, Na(+)- translocating, D subunit DNO_0808 76 COG1347 NqrD, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD Energy production and conversion 146329906 Common fimO type IV fimbrial biogenesis protein FimO DNO_1125 148 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 146329376 Common - transposase IS200-like protein DNO_0328 69 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 146329588 Common ubiB 2-polyprenylphenol 6-hydroxylase DNO_0441 184 COG0661 AarF, Predicted unusual protein kinase General function prediction only 146328842 Common - type IV fimbrial biogenesis protein DNO_0891 23 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 146329247 Pathogen - hypothetical lipoprotein DNO_1329 1 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 146328658 Common gap glyceraldehyde-3-phosphate dehydrogenase DNO_0092 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 146329542 Pathogen - hypothetical protein DNO_0729 1 None None None 146328732 Common agcS sodium:alanine symporter family protein DNO_0828 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 146328639 Common - hypothetical protein DNO_0649 163 COG1162 COG1162, Predicted GTPases General function prediction only 146328984 Common - TatD family deoxyribonuclease DNO_0727 235 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 146328692 Common atpG ATP synthase F1, gamma subunit DNO_1143 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 146329668 Common rpsJ 30S ribosomal protein S10 DNO_1276 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 146329630 Common atpA ATP synthase F1, alpha subunit DNO_1144 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 146328699 Common - hypothetical protein DNO_0867 7 COG1406 COG1406, Predicted inhibitor of MCP methylation, homolog of CheC Cell motility and secretion 146328685 Common murG N-acetylglucosaminyltransferase, MurG DNO_0981 207 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 146329402 Common gcvT glycine cleavage system T protein DNO_1197 179 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 146329770 Common - hypothetical protein DNO_0928 86 COG2321 COG2321, Predicted metalloprotease General function prediction only 146328813 Common alaS alanyl-tRNA synthetase DNO_0286 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146329154 Common metG methionyl-trna synthetase DNO_0934 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146329699 Common - phospho-2-dehydro-3-heoxyheptonate aldolase DNO_1003 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 146329125 Common pyrF orotidine 5'-phosphate decarboxylase DNO_0564 161 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 146329882 Common - hypothetical protein DNO_0639 71 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 146329679 Common - cell division protein FtsQ DNO_0978 64 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 146328830 Common rph ribonuclease PH DNO_0664 187 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 146329766 Common - hypothetical protein DNO_1095 3 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 146328715 Pathogen vapG1 virulence-associated protein VapG1 DNO_0280 1 None None None 146328889 Common nqrE Na(+)-translocating NADH-quinone reductase subunit E DNO_0807 76 COG2209 NqrE, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE Energy production and conversion 146329897 Common rpmG 50S ribosomal protein L33 DNO_0061 144 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 146329319 Common rimI ribosomal-protein-alanine acetyltransferase DNO_0933 163 COG0456 RimI, Acetyltransferases General function prediction only 146329528 Common - hypothetical protein DNO_0195 12 COG2013 COG2013, Uncharacterized conserved protein Function unknown 146329192 Common - isopentenyl pyrophosphate isomerase DNO_0798 85 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 146328748 Common trxA thioredoxin I DNO_0737 233 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 146328902 Common - lactoylglutathione lyase DNO_0735 111 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 146328865 Common - TerC family protein DNO_1216 94 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 146329908 Common - hypothetical protein DNO_0841 36 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 146329172 Common - hypothetical protein DNO_0944 10 COG4690 PepD, Dipeptidase Amino acid transport and metabolism 146328657 Common - OmpA family domain protein DNO_0312 4 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 146329330 Common - ATPase family protein DNO_0508 234 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146329486 Common - hypothetical protein DNO_0341 62 COG3108 COG3108, Uncharacterized protein conserved in bacteria Function unknown 146329281 Common - hypothetical protein DNO_0358 193 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 146329695 Common lpxA acyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase DNO_0685 163 COG1043 LpxA, Acyl- acyl carrier protein 146329576 Common pgsA CDP-diacylglycerol--glycerol-3-phosphate 3- phosphatidyltransferase DNO_0306 204 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 146329083 Pathogen - hypothetical protein DNO_0621 1 None None None 146329701 Common pssA CDP-diacylglycerol--serine O- phosphatidyltransferase DNO_0565 148 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 146329641 Common dcpB peptidyl-dipeptidase II DNO_1352 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 146329551 Common pepT-1 peptidase T DNO_0201 63 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 146329726 Common prmA ribosomal protein L11 methyltransferase DNO_0422 171 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 146329138 Common accA acetyl-CoA carboxylase, alpha subunit DNO_1091 203 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 146329685 Common deoC deoxyribose-phosphate aldolase DNO_0909 137 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 146328647 Common csy4 hypothetical protein DNO_0170 18 None None None 146329063 Common - hypothetical protein DNO_0392 137 COG0730 COG0730, Predicted permeases General function prediction only 146328826 Common ychF GTP-binding protein DNO_1325 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 146328932 Common - hypothetical protein DNO_0224 73 COG3176 COG3176, Putative hemolysin General function prediction only 146328834 Common - hypothetical protein DNO_0960 33 None None None 146329018 Common - phosphoribosylformylglycinamidine synthase DNO_1110 233 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 146328792 Common - heptosyltransferase family protein DNO_0888 100 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 146329739 Pathogen vapH virulence-associated protein VapH DNO_0281 1 None None None 146329346 Common - NADPH-dependent FMN reductase DNO_0091 86 COG0431 COG0431, Predicted flavoprotein General function prediction only 146329306 Common - N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase DNO_0652 222 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 146329683 Common - AbgT transporter family protein DNO_0200 38 COG2978 AbgT, Putative p-aminobenzoyl-glutamate transporter Coenzyme metabolism 146329773 Common cca tRNA nucleotidyltransferase DNO_1060 210 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 146329661 Common - carbonic anhydrase DNO_1085 121 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 146329504 Common efp translation elongation factor P DNO_1326 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 146329370 Common frdA fumarate reductase flavoprotein subunit DNO_1026 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 146328744 Common - hypothetical protein DNO_0628 113 COG1806 COG1806, Uncharacterized protein conserved in bacteria Function unknown 146329385 Common ribD riboflavin biosynthesis protein RibD DNO_0474 231 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 146329075 Common vrlC conserved hypothetical protein VrlC DNO_0189 8 None None None 146329399 Common aat leucyl/phenylalanyl-tRNA--protein transferase DNO_0680 134 COG2360 Aat, Leu/Phe-tRNA-protein transferase Posttranslational modification, protein turnover, chaperones 146328925 Common sdaA L-serine dehydratase DNO_0619 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 146329276 Common uvrD-2 DNA helicase UvrD DNO_0381 231 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 146329263 Common - hypothetical protein DNO_0804 28 COG2991 COG2991, Uncharacterized protein conserved in bacteria Function unknown 146328857 Common - hypothetical protein DNO_0368 50 COG2035 COG2035, Predicted membrane protein Function unknown 146329524 Common - hypothetical protein DNO_0629 41 COG2915 COG2915, Uncharacterized protein involved in purine metabolism General function prediction only 146329181 Common - transglycosylase SLT domain protein DNO_0635 169 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 146328824 Common fmt methionyl-tRNA formyltransferase DNO_0157 216 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 146329110 Common - hypothetical protein DNO_0990 65 COG2914 COG2914, Uncharacterized protein conserved in bacteria Function unknown 146328756 Common zwf glucose-6-phosphate 1-dehydrogenase DNO_1223 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 146329677 Common - metallo-beta-lactamase superfamily protein DNO_0993 207 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 146329040 Common - hypothetical protein DNO_0098 2 None None None 146329177 Common hemC porphobilinogen deaminase DNO_0299 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 146329218 Common asd aspartate-semialdehyde dehydrogenase DNO_1053 191 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 146329737 Common - hypothetical protein DNO_0133 45 None None None 146329412 Common fimB fimbrial protein FimB DNO_0109 10 None None None 146329717 Common trmB tRNA (guanine-N(7)-)-methyltransferase DNO_1247 177 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 146329268 Common pal OmpA domain protein DNO_1171 146 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 146329105 Common groEL chaperonin GroEL DNO_1339 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 146329047 Common - cation efflux family protein DNO_0659 205 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 146328840 Pathogen - hypothetical protein DNO_0268 1 None None None 146329080 Common lpxH UDP-2,3-diacylglucosamine hydrolase DNO_0211 73 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 146329872 Common lon ATP-dependent protease La DNO_0227 228 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 146329193 Common - hypothetical protein DNO_0192 18 None None None 146329335 Common - two-component sensor kinase DNO_0900 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 146329322 Common - hypothetical protein DNO_0563 59 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 146329600 Common rpoB DNA-directed RNA polymerase, beta subunit DNO_1282 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 146329755 Common lipB lipoate-protein ligase B DNO_0897 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 146328688 Pathogen - hypothetical protein DNO_1185 1 None None None 146329862 Common - hypothetical protein DNO_0881 7 COG5266 CbiK, ABC-type Co2+ transport system, periplasmic component Inorganic ion transport and metabolism 146328847 Pathogen - hypothetical protein DNO_1315 2 None None None 146328996 Pathogen - hypothetical protein DNO_0759 1 None None None 146329441 Common parC DNA topoisomerase IV subunit A DNO_0678 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 146329448 Common - acyl-CoA thioester hydrolase DNO_0830 132 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 146329535 Common - hypothetical protein DNO_1105 24 COG2841 COG2841, Uncharacterized protein conserved in bacteria Function unknown 146329007 Common murE UDP-N-acetylmuramoylalanyl-D-glutamate--2,6- diaminopimelat e ligase DNO_0986 208 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 146329825 Common pyrB aspartate carbamoyltransferase DNO_0490 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 146328749 Common - NUDIX hydrolase domain protein DNO_0139 102 COG1056 NadR, Nicotinamide mononucleotide adenylyltransferase Coenzyme metabolism 146328928 Common - ROK family protein DNO_0705 152 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 146329297 Common - potential adhesin complex protein DNO_0725 3 None None None 146329145 Common murA UDP-N-acetylglucosamine 1- carboxyvinyltransferase DNO_0853 209 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 146329022 Common vapD1 virulence-associated protein VapD1 DNO_0278 7 COG3309 VapD, Uncharacterized virulence-associated protein D Function unknown 146328964 Common - PTS phosphocarrier protein HPr DNO_0119 128 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 146328775 Common lipA lipoyl synthase DNO_0480 191 COG0320 LipA, Lipoate synthase Coenzyme metabolism 146328670 Common - NUDIX hydrolase domain protein DNO_0972 153 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 146328954 Common rpmE ribosomal protein L31 DNO_0417 175 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 146328662 Common - hypothetical protein DNO_0518 17 COG2976 COG2976, Uncharacterized protein conserved in bacteria Function unknown 146328679 Common cysQ 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'- phosphatase DNO_1011 179 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 146329206 Common - ABC-type phosphate-dependent transport system family protein DNO_1182 222 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 146329586 Common rpsA ribosomal protein S1 DNO_0113 222 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 146328994 Common - hypothetical protein DNO_0135 17 COG5266 CbiK, ABC-type Co2+ transport system, periplasmic component Inorganic ion transport and metabolism 146328773 Common - hypothetical protein DNO_0390 11 COG3115 ZipA, Cell division protein Cell division and chromosome partitioning 146329786 Common - hypothetical protein DNO_0930 48 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 146329884 Common - hypothetical protein DNO_0253 84 COG2961 ComJ, Protein involved in catabolism of external DNA General function prediction only 146329217 Common - transposase, IS200 family DNO_1342 68 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 146329065 Common - hypothetical protein DNO_0782 4 None None None 146329805 Pathogen - hypothetical protein DNO_1030 4 None None None 146328703 Common thrS threonyl-tRNA synthetase DNO_0527 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146329573 Common - Gram-negative porin family protein DNO_0494 38 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 146329768 Common - LysM domain protein DNO_0155 44 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 146328706 Common hemH ferrochelatase DNO_1249 157 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 146329329 Common vrlL S-adenosyl-L-methionine-dependent methyltransferases family protein VrlL DNO_0180 12 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 146328725 Common - hypothetical protein DNO_1160 7 COG4285 COG4285, Uncharacterized conserved protein Function unknown 146328665 Common - RNA methylase family protein DNO_1316 156 COG0116 COG0116, Predicted N6-adenine-specific DNA methylase DNA replication, recombination, and repair 146329852 Common miaB tRNA-i(6)A37 thiotransferase enzyme MiaB DNO_1245 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 146329526 Common - ABC transporter domain protein DNO_0257 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 146328914 Common pilO type IV fimbrial biogenesis protein PilO DNO_0346 35 COG3167 PilO, Tfp pilus assembly protein PilO Cell motility and secretion / Intracellular trafficking and secretion 146329143 Common - hypothetical protein DNO_0037 13 COG5373 COG5373, Predicted membrane protein Function unknown 146329517 Common - arabinose 5-phosphate isomerase DNO_0536 151 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 146329114 Common - hypothetical protein DNO_0898 28 COG2921 COG2921, Uncharacterized conserved protein Function unknown 146329103 Common - phage virion morphogenesis-like protein DNO_0745 25 COG2369 COG2369, Uncharacterized protein, homolog of phage Mu protein gp30 Function unknown 146329565 Common vapI virulence-associated protein VapI DNO_0272 81 COG3093 VapI, Plasmid maintenance system antidote protein General function prediction only 146329056 Pathogen - hypothetical protein DNO_0145 1 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 146329266 Common - paraquat-inducible protein B family DNO_0497 64 COG3008 PqiB, Paraquat-inducible protein B General function prediction only 146329499 Common - hypothetical protein DNO_0651 212 COG0628 PerM, Predicted permease General function prediction only 146328735 Common pgi glucose-6-phosphate isomerase DNO_0163 199 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 146328942 Common tpiA triosephosphate isomerase DNO_0814 215 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 146329439 Common yfeA periplasmic iron-binding protein YfeA DNO_0644 169 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 146329826 Common - penicillin-binding protein 2 DNO_0964 202 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 146329904 Common pyk pyruvate kinase DNO_1200 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 146328709 Common purA adenylosuccinate synthetase DNO_0600 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 146329430 Common toxA1 plasmid maintenance system killer family protein ToxA1 DNO_0274 40 COG3549 HigB, Plasmid maintenance system killer protein General function prediction only 146329420 Common proC pyrroline-5-carboxylate reductase DNO_0674 211 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 146328758 Common - inositol monophosphatase DNO_0803 210 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 146329045 Common kdtA 3-Deoxy-D-manno-octulosonic-acid transferase DNO_1296 126 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 146329890 Common - transglycosylase SLT domain protein DNO_0634 166 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 146329454 Common fabH 3-oxoacyl-(acyl-carrier-protein) synthase III DNO_1207 225 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 146329775 Common gcvP glycine dehydrogenase DNO_1069 172 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 146329366 Common - beta-hexosaminidase DNO_0021 171 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 146329251 Common hemA glutamyl-tRNA reductase DNO_0069 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 146329761 Common - hypothetical protein DNO_0371 24 COG3698 COG3698, Predicted periplasmic protein Function unknown 146329602 Common rplS 50S ribosomal protein L19 DNO_1010 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 146329798 Common parE DNA topoisomerase IV subunit B DNO_0677 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 146329832 Common trmA tRNA (uracil-5-)-methyltransferase DNO_1163 139 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 146329468 Common nqrF Na(+)-translocating NADH-quinone reductase subunit F DNO_0806 163 COG2871 NqrF, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF Energy production and conversion 146329380 Common minD septum site-determining protein MinD DNO_0914 141 COG2894 MinD, Septum formation inhibitor-activating ATPase Cell division and chromosome partitioning 146328819 Common - Septum formation initiator family protein DNO_0363 2 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 146329165 Common vrlO DEAD helicase domain protein VrlO DNO_0177 217 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 146328784 Common rpsC 30S ribosomal protein S3 DNO_1269 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 146329746 Common - hypothetical protein DNO_0297 2 COG2959 HemX, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 146329317 Common - hypothetical protein DNO_1179 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 146329227 Common purE phosphoribosylaminoimidazole carboxylase, catalytic subunit DNO_0077 230 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 146328887 Common - redox-active disulfide protein family DNO_0413 67 None None None 146328810 Common - sulfate transporter family protein DNO_0698 164 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 146329843 Common - Dps family protein DNO_1318 145 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 146328855 Common sbcD exonuclease SbcD DNO_0365 100 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 146329583 Common - short-chain dehydrogenase/reductase family protein DNO_0531 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 146329866 Common glyQ glycyl-tRNA synthetase subunit alpha DNO_0701 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 146328900 Common hemE uroporphyrinogen decarboxylase DNO_1332 182 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 146329392 Common dacB D-alanyl-D-alanine carboxypeptidase C, S13 family DNO_0129 105 COG2027 DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) Cell envelope biogenesis, outer membrane 146329199 Common - peptidylprolyl cis-trans isomerase DNO_0916 90 None None None 146329841 Common rpoN RNA polymerase sigma-54 factor DNO_0532 145 COG1508 RpoN, DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog Transcription 146328863 Common - hypothetical protein DNO_1015 26 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 146329899 Common - ABC transporter family protein DNO_0547 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 146329492 Pathogen - hypothetical membrane protein DNO_1319 1 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 146329209 Common vrlH conserved hypothetical protein VrlH DNO_0184 8 COG2105 COG2105, Uncharacterized conserved protein Function unknown 146329859 Common - stringent starvation protein B DNO_0850 64 COG2969 SspB, Stringent starvation protein B General function prediction only 146329151 Common - lytic murein transglycosylase DNO_0633 149 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 146329473 Common gshA glutamate--cysteine ligase DNO_1217 58 COG2918 GshA, Gamma-glutamylcysteine synthetase Coenzyme metabolism 146329850 Common - tyrosine phenol-lyase DNO_0442 44 COG3033 TnaA, Tryptophanase Amino acid transport and metabolism 146329127 Pathogen omp1D outer membrane protein 1D DNO_0384 1 None None None 146328905 Common pta phosphate acetyltransferase DNO_0448 173 COG0280 Pta, Phosphotransacetylase Energy production and conversion 146329632 Common - TetR family transcriptional regulator DNO_0445 23 COG1309 AcrR, Transcriptional regulator Transcription 146329200 Common - ribonucleotide reductase, beta subunit DNO_0608 85 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 146329249 Common dnaK chaperone protein DnaK DNO_0826 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 146329025 Common mutS DNA mismatch repair protein MutS DNO_1303 202 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 146328880 Common - alanine racemase domain protein DNO_0204 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 146328785 Common - OsmC-like protein DNO_0786 82 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 146329544 Common - hypothetical protein DNO_1224 47 COG3762 COG3762, Predicted membrane protein Function unknown 146329351 Common - tetrapyrrole methylase family protein DNO_0641 209 COG0313 COG0313, Predicted methyltransferases General function prediction only 146329666 Common - transcriptional accessory protein DNO_1159 142 COG2183 Tex, Transcriptional accessory protein Transcription 146329624 Common glmM phosphoglucosamine mutase DNO_0815 240 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 146329429 Common clpP ATP-dependent Clp protease, proteolytic subunit ClpP DNO_0229 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 146329728 Pathogen - hypothetical protein DNO_0974 1 None None None 146329665 Common - bacteriophage P4-like integrase DNO_0784 103 COG0582 XerC, Integrase DNA replication, recombination, and repair 146329418 Common dsbA thiol:disulfide interchange protein DsbA DNO_0511 66 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 146329874 Pathogen - hypothetical protein DNO_0122 1 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 146329534 Common fabD malonyl CoA-acyl carrier protein transacylase DNO_1208 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 146329599 Common argS arginyl-tRNA synthetase DNO_1051 248 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146329581 Common holA DNA polymerase III, delta subunit DNO_0244 60 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 146328951 Common - hypothetical protein DNO_1246 84 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 146329876 Common toxA2 plasmid maintenance system killer family protein ToxA2 DNO_1039 40 COG3549 HigB, Plasmid maintenance system killer protein General function prediction only 146329693 Common - hypothetical protein DNO_1098 92 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 146329426 Common murC UDP-N-acetylmuramate-alanine ligase DNO_0980 209 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 146329131 Common - conserved hypothetical lipoprotein DNO_0248 88 COG2358 Imp, TRAP-type uncharacterized transport system, periplasmic component General function prediction only 146329610 Common vapB1 virulence-associated protein VapB1 DNO_0276 21 COG4456 VagC, Virulence-associated protein and related proteins Function unknown 146328736 Pathogen - hypothetical protein DNO_0461 1 None None None 146329754 Common rnd ribonuclease D DNO_1123 105 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 146329271 Common rodA rod shape determining protein DNO_0963 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 146328852 Common - mce related family protein DNO_0857 101 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 146329026 Common rpsF ribosomal protein S6 DNO_1121 191 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 146329411 Common tolB TolB protein DNO_1172 152 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 146328795 Common kamA lysine 2,3-aminomutase DNO_0590 125 COG1509 KamA, Lysine 2,3-aminomutase Amino acid transport and metabolism 146328990 Common purB adenylosuccinate lyase DNO_0667 234 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 146329379 Common - Mechanosensitive ion channel family DNO_0053 175 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 146328631 Common frdC fumarate reductase, subunit C DNO_1028 22 COG3029 FrdC, Fumarate reductase subunit C Energy production and conversion 146328997 Common trmE tRNA modification GTPase TrmE DNO_0948 225 COG0486 ThdF, Predicted GTPase General function prediction only 146329592 Common maf-2 Maf-like protein DNO_1000 191 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 146329460 Common pilP type IV fimbrial biogenesis protein PilP DNO_0347 4 COG3168 PilP, Tfp pilus assembly protein PilP Cell motility and secretion / Intracellular trafficking and secretion 146328968 Common - chorismate binding family protein DNO_0646 224 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 146329675 Common - hypothetical protein DNO_0171 9 COG1783 XtmB, Phage terminase large subunit General function prediction only 146329108 Common - hypothetical protein DNO_1243 196 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 146329035 Common - hypothetical protein DNO_0045 131 COG1739 COG1739, Uncharacterized conserved protein Function unknown 146329390 Common dapB dihydrodipicolinate reductase DNO_0561 217 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 146328641 Common pyrH uridylate kinase DNO_0721 228 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 146329891 Pathogen - hypothetical protein DNO_0147 1 None None None 146329253 Pathogen - hypothetical protein DNO_0713 1 COG3027 COG3027, Uncharacterized protein conserved in bacteria Function unknown 146329561 Common uspA universal stress family protein DNO_0011 36 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 146329237 Common - hypothetical protein DNO_1152 86 COG0795 COG0795, Predicted permeases General function prediction only 146329888 Common - hypothetical protein DNO_0758 2 None None None 146328958 Common rnfE electron transport complex protein, E subunit DNO_0550 76 COG4660 RnfE, Predicted NADH:ubiquinone oxidoreductase, subunit RnfE Energy production and conversion 146329780 Common rpmI 50S ribosomal protein L35 DNO_0525 3 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 146328651 Common - potential RTX family protein DNO_0334 84 None None None 146329241 Common argF-2 ornithine carbamoyltransferase DNO_1335 238 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 146329286 Common - partioning protein, ParB/SpoJ family DNO_1149 184 COG1475 Spo0J, Predicted transcriptional regulators Transcription 146328981 Common - hypothetical protein DNO_0317 67 COG1636 COG1636, Uncharacterized protein conserved in bacteria Function unknown 146329248 Common - ATP-dependent RNA helicase DNO_1017 241 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 146329278 Common aroC chorismate synthase DNO_1072 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 146328829 Common lpxB lipid-A-disaccharide synthase DNO_0686 140 COG0763 LpxB, Lipid A disaccharide synthetase Cell envelope biogenesis, outer membrane 146329644 Common - peptidase SspA family DNO_0999 160 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 146329505 Common - formate/nitrite transporter family protein DNO_0880 92 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 146329867 Common - hypothetical protein DNO_0942 181 COG1496 COG1496, Uncharacterized conserved protein Function unknown 146329453 Common vapC2 virulence-associated protein VapC2 DNO_1042 62 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 146328674 Common - aminoacyl-histidine dipeptidase DNO_0013 56 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 146329484 Common - SPFH domain - Band 7 family protein DNO_0373 221 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 146329638 Common yfeC ABC iron transporter YfeC DNO_0642 185 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 146329629 Common rpe ribulose-phosphate 3-epimerase DNO_0540 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 146329183 Common - hypothetical protein DNO_0757 10 None None None 146328836 Common ihfB integration host factor, beta subunit DNO_0114 202 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 146329642 Pathogen - hypothetical lipoprotein DNO_0024 1 None None None 146328763 Common mreB rod shape-determining protein MreB DNO_0967 211 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 146329089 Common - S-adenosylmethionine-dependent methyltransferase DNO_0661 36 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 146328754 Common - OmpH family protein DNO_0682 51 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 146329096 Common smpB SsrA-binding protein DNO_0992 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 146328802 Common rplF 50S ribosomal protein L6 DNO_1260 228 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 146329708 Pathogen - hypothetical protein DNO_0927 1 None None None 146329308 Common - methyltransferase family protein DNO_0482 45 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 146328915 Common - aminodeoxychorismate lyase family protein DNO_1212 185 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 146328794 Common scpA hypothetical protein DNO_0477 138 COG1354 COG1354, Uncharacterized conserved protein Function unknown 146329066 Common lpxK tetraacyldisaccharide 4'-kinase DNO_0843 126 COG1663 LpxK, Tetraacyldisaccharide-1-P 4'-kinase Cell envelope biogenesis, outer membrane 146328637 Common - peptidylprolyl cis-trans isomerase, cyclophilin- type DNO_0210 198 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 146329787 Common - leucine aminopeptidase DNO_1151 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 146329289 Common - carboxyl-terminal protease family protein DNO_0543 181 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 146328814 Common - hypothetical membrane protein DNO_1225 83 COG1512 COG1512, Beta-propeller domains of methanol dehydrogenase type General function prediction only 146329720 Pathogen - hypothetical protein DNO_1195 1 None None None 146329489 Common dcuCB C4-dicarboxylate anaerobic carrier, DcuC family protein DNO_1354 24 COG3069 DcuC, C4-dicarboxylate transporter Energy production and conversion 146329479 Common gyrA DNA gyrase subunit A DNO_0321 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 146328934 Common - hypothetical protein DNO_0255 93 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 146328649 Common ftsI cell division protein FtsI DNO_0987 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 146329012 Common - hypoxanthine-guanine phosphoribosyltransferase DNO_0023 147 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 146328877 Common vrlQ conserved hypothetical protein VrlQ DNO_0175 6 None None None 146328776 Common minC septum formation inhibitor MinC DNO_0915 111 COG0850 MinC, Septum formation inhibitor Cell division and chromosome partitioning 146328661 Common - lipoprotein, putative DNO_0580 13 None None None 146329634 Common - hypothetical protein DNO_0400 142 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 146329458 Common - FxsA cytoplasmic membrane protein family DNO_0205 68 COG3030 FxsA, Protein affecting phage T7 exclusion by the F plasmid General function prediction only 146329463 Common phoH phospahte starvation induced protein PhoH DNO_1244 198 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 146329382 Common tilS tRNA(Ile)-lysidine synthetase DNO_0359 213 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 146329294 Common gatB glutamyl-tRNA(Gln) amidotransferase, B subunit DNO_0349 213 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 146328870 Common - TrkA-N domain family protein DNO_0581 53 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 146329406 Common secD preprotein translocase, SecD subunit DNO_0039 218 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 146328988 Pathogen - hypothetical protein DNO_0765 1 None None None 146329189 Common - hydroxymethylglutaryl-coenzyme A reductase DNO_0797 38 COG1257 HMG1, Hydroxymethylglutaryl-CoA reductase Lipid metabolism 146329168 Common secA preprotein translocase, SecA subunit DNO_0973 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 146329503 Pathogen - hypothetical lipoprotein DNO_0300 1 None None None 146329341 Pathogen - hypothetical protein DNO_0715 1 None None None 146328861 Common mraW S-adenosyl-methyltransferase MraW DNO_0989 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 146329158 Pathogen - hypothetical protein DNO_0465 1 None None None 146329269 Common - O-antigen ligase DNO_0791 20 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 146329791 Common - macrolide-specific ABC-type efflux protein DNO_0871 174 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 146329490 Common uppS undecaprenyl diphosphate synthase DNO_0719 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 146329626 Common - hypothetical protein DNO_0752 4 None None None 146328696 Common murB UDP-N-acetylenolpyruvoylglucosamine reductase DNO_0436 186 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 146329782 Common dapD 2,3,4,5-tetrahydropyridine-2-carboxylate N- succinyltransferase DNO_0817 139 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 146329844 Common - para-aminobenzoate synthetase, component II DNO_1127 237 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 146328635 Pathogen - hypothetical lipoprotein DNO_0496 1 COG3009 COG3009, Uncharacterized protein conserved in bacteria Function unknown 146329886 Pathogen - hypothetical protein DNO_0617 1 None None None 146329311 Common - hypothetical protein DNO_0127 83 COG2358 Imp, TRAP-type uncharacterized transport system, periplasmic component General function prediction only 146329710 Common vrlS DEAD-DEAH box helicase domain protein VrlS DNO_0173 102 COG1204 COG1204, Superfamily II helicase General function prediction only 146329907 Common ispA geranyltranstransferase DNO_0648 240 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 146328723 Common pilZ type IV fimbrial biogenesis protein PilZ DNO_1215 33 COG3215 PilZ, Tfp pilus assembly protein PilZ Cell motility and secretion / Intracellular trafficking and secretion 146328653 Common typA GTP-binding protein TypA DNO_0350 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 146329141 Pathogen - hypothetical protein DNO_0303 1 COG2835 COG2835, Uncharacterized conserved protein Function unknown 146329545 Common infA translation initiation factor IF-1 DNO_1198 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 146329893 Common tolR TolR protein DNO_1174 128 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 146328918 Common - hypothetical protein DNO_0141 218 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 146329212 Pathogen - hypothetical protein DNO_0764 1 None None None 146329009 Common - acyltransferase family protein DNO_0225 125 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 146328711 Common ruvC crossover junction endodeoxyribonuclease RuvC DNO_1178 197 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 146329513 Common luxS S-ribosylhomocysteinase DNO_0395 55 COG1854 LuxS, LuxS protein involved in autoinducer AI2 synthesis Signal transduction mechanisms 146329497 Common - hypothetical protein DNO_0150 38 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 146329902 Pathogen - hypothetical protein DNO_0738 1 None None None 146329051 Common - helicase family protein DNO_1054 45 COG3972 COG3972, Superfamily I DNA and RNA helicases General function prediction only 146329432 Common - drug resistance transporter DNO_0505 205 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146329857 Common - hypothetical protein DNO_0616 62 COG5394 COG5394, Uncharacterized protein conserved in bacteria Function unknown 146329651 Common - hypothetical protein DNO_0301 42 COG4582 COG4582, Uncharacterized protein conserved in bacteria Function unknown 146329830 Common - PmbA protein DNO_0578 150 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 146329372 Common rplM 50S ribosomal protein L13 DNO_1129 238 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 146328671 Common - hypothetical protein DNO_0249 31 COG1409 Icc, Predicted phosphohydrolases General function prediction only 146329129 Common rplJ 50S ribosomal protein L10 DNO_1284 202 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 146328708 Common - ABC transporter family ATP-binding protein DNO_0533 249 COG1137 YhbG, ABC-type (unclassified) transport system, ATPase component General function prediction only 146328741 Common - two-component sensor kinase DNO_0869 149 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 146329239 Common tsf elongation factor Ts DNO_0722 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 146329560 Common - hypothetical protein DNO_0499 113 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 146329779 Pathogen - hypothetical protein DNO_0781 1 None None None 146329449 Common rplB 50S ribosomal protein L2 DNO_1272 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 146329722 Common dsbB thiol:disulfide interchange protein DsbB DNO_0666 27 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 146329230 Pathogen - hypothetical protein DNO_0378 1 None None None 146329762 Common folD methylenetetrahydrofolate dehydrogenase DNO_1298 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 146329719 Common - sulfatase domain protein DNO_0530 60 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 146328962 Common eno enolase DNO_0362 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 146329570 Common - choline-carnitine o-acyltransferase family protein DNO_0679 7 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 146328921 Common - hypothetical protein DNO_0062 102 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 146328945 Pathogen - septum formation topological specificity factor MinE superfamily protein DNO_0913 1 COG0851 MinE, Septum formation topological specificity factor Cell division and chromosome partitioning 146329818 Common - haloacid dehalogenase family protein DNO_0593 97 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 146328765 Common yfeB ABC iron transporter ATP-binding protein YfeB DNO_0643 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 146329539 Common folP dihydropteroate synthase DNO_1237 218 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 146329323 Common - hydroxyethylthiazole kinase DNO_0932 77 COG2145 ThiM, Hydroxyethylthiazole kinase, sugar kinase family Coenzyme metabolism 146329178 Common ftsZ cell division protein FtsZ DNO_0976 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 146329225 Common - 7-cyano-7-deazaguanine reductase DNO_0818 145 COG0780 COG0780, Enzyme related to GTP cyclohydrolase I General function prediction only 146328898 Common folA dihydrofolate reductase DNO_0789 145 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 146329567 Pathogen - hypothetical membrane protein DNO_0638 1 None None None 146329605 Common tolQ TolQ protein DNO_1175 151 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 146329772 Common atpF ATP synthase F0, B subunit DNO_1146 138 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 146329577 Common - bacterial extracellular solute-binding family protein DNO_0606 133 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 146329515 Common ftsY signal recognition particle FtsY DNO_0875 248 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 146329361 Common - hypothetical protein DNO_0748 18 None None None 146328975 Common suC succinyl-CoA synthetase, beta subunit DNO_1312 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 146329353 Common - metallo-hydrolase family protein DNO_0785 87 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 146329807 Common - hypothetical protein DNO_1336 142 COG2081 COG2081, Predicted flavoproteins General function prediction only 146329106 Common - M23peptidase domain protein DNO_1322 191 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 146328817 Common - Amino acid transporter superfamily DNO_0015 161 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146328903 Pathogen omp1E outer membrane protein 1E DNO_0383 1 None None None 146329043 Common - competence ComEA family protein DNO_1230 115 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 146329198 Common - competence protein ComEA-related protein DNO_1304 115 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 146329202 Common lspA signal peptidase II DNO_0084 200 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 146329527 Common ileS isoleucyl-tRNA synthetase DNO_0083 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146328729 Common trpS tryptophanyl-tRNA synthetase DNO_0236 232 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146329396 Common vrlK conserved hypothetical protein VrlK DNO_0181 8 None None None 146328992 Common pilN type IV fimbrial assembly protein PilN DNO_0345 13 COG3166 PilN, Tfp pilus assembly protein PilN Cell motility and secretion / Intracellular trafficking and secretion 146329101 Common rplA 50S ribosomal protein L1 DNO_1285 247 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 146328797 Common aceF dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex DNO_0545 197 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 146329033 Pathogen - camphor resistance (CrcB) family protein DNO_1324 1 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 146329759 Common - Mg chelatase family protein DNO_0203 197 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 146328999 Common - bacteriophage recombination function protein DNO_0769 5 None None None 146328875 Common - aminopeptidase, M1 family DNO_0019 158 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 146328850 Common greA transcription elongation factor GreA DNO_1184 204 COG0782 GreA, Transcription elongation factor Transcription 146328633 Common recR recombination protein RecR DNO_0953 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 146329594 Common - guanylate kinase DNO_0645 213 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 146329031 Common rpoA DNA-directed RNA polymerase, alpha subunit DNO_1251 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 146329444 Common - hypothetical protein DNO_0252 24 COG3594 NolL, Fucose 4-O-acetylase and related acetyltransferases Carbohydrate transport and metabolism 146328891 Common rpsR 30S ribosomal protein S18 DNO_1120 215 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 146329173 Common - conserved hypothetical lipoprotein DNO_0313 74 COG2989 COG2989, Uncharacterized protein conserved in bacteria Function unknown 146329028 Common - HemY protein DNO_0296 27 COG3071 HemY, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 146329869 Common - plasmid maintenance system killer family protein DNO_0273 57 COG3549 HigB, Plasmid maintenance system killer protein General function prediction only 146329003 Common - OmpA family protein DNO_0320 165 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 146329532 Pathogen - hypothetical protein DNO_0766 1 COG3311 AlpA, Predicted transcriptional regulator Transcription 146329752 Common holC DNA polymerase III chi subunit DNO_0457 26 COG2927 HolC, DNA polymerase III, chi subunit DNA replication, recombination, and repair 146329477 Common - two-component response regulator DNO_0868 224 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 146329425 Common - VacJ-like lipoprotein DNO_0650 94 COG2853 VacJ, Surface lipoprotein Cell envelope biogenesis, outer membrane 146329658 Common - Aromatic-Rich family protein DNO_0991 102 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 146329878 Common maeB malic enzyme DNO_0020 215 COG0281 SfcA, Malic enzyme Energy production and conversion 146328752 Common ffh signal recognition particle protein DNO_0428 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 146328806 Pathogen - hypothetical protein DNO_0044 1 None None None 146328943 Common - endodeoxyribonuclease RusA family DNO_0780 8 COG4570 Rus, Holliday junction resolvase DNA replication, recombination, and repair 146329691 Pathogen - hypothetical protein DNO_1012 1 None None None 146329612 Common - hypothetical protein DNO_1166 14 None None None 146329011 Common - hypothetical protein DNO_0234 7 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 146328804 Common - fumarate reductase, subunit D DNO_1029 20 COG3080 FrdD, Fumarate reductase subunit D Energy production and conversion 146329500 Common - D-isomer specific 2-hydroxyacid dehydrogenase family protein DNO_0848 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 146329557 Common - response regulator receiver domain protein DNO_0821 220 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 146329883 Common - ABC transporter family protein DNO_0455 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 146329706 Common mvaD diphosphomevalonate decarboxylase DNO_0504 32 COG3407 MVD1, Mevalonate pyrophosphate decarboxylase Lipid metabolism 146329134 Pathogen - hypothetical protein DNO_0840 1 None None None 146329095 Common rpsE 30S ribosomal protein S5 DNO_1258 243 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 146329087 Common pilC type IV fimbrial tip adhesin DNO_0895 27 COG3419 PilY1, Tfp pilus assembly protein, tip-associated adhesin PilY1 Cell motility and secretion / Intracellular trafficking and secretion 146328676 Pathogen - hypothetical protein DNO_0751 1 None None None 146329839 Common - xaa-pro aminopeptidase DNO_0429 221 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 146329000 Pathogen - hypothetical protein DNO_1156 1 None None None 146329222 Common apt adenine phosphoribosyltransferase DNO_0414 177 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 146329078 Pathogen vapG3 virulence-associated protein VapG3 DNO_1044 1 None None None 146329789 Common glf UDP-galactopyranose mutase DNO_0338 58 COG0562 Glf, UDP-galactopyranose mutase Cell envelope biogenesis, outer membrane 146328643 Common frr ribosome recycling factor DNO_0720 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 146329185 Common - ABC transporter domain protein DNO_0443 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 146329068 Common fabG 3-oxoacyl-(acyl-carrier-protein) reductase DNO_1209 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 146328892 Common - membrane-bound lytic murein transglycosylase DNO_0962 103 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 146329325 Common - hypothetical protein DNO_0079 57 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 146329615 Common - sugar transferase family protein DNO_0340 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 146329689 Common rpmB 50S ribosomal protein L28 DNO_0060 159 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 146328812 Common nqrC Na(+)-translocating NADH-quinone reductase subunit C DNO_0809 46 COG2869 NqrC, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC Energy production and conversion 146329487 Common - hypothetical protein DNO_0478 157 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 146329284 Common rpsO 30S ribosomal protein S15 DNO_1048 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 146329301 Common mreC rod shape-determining protein MreC DNO_0966 149 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 146328831 Common - hypothetical protein DNO_0523 35 COG2938 COG2938, Uncharacterized conserved protein Function unknown 146329734 Common - ABC-type phosphate-dependent transport system family protein DNO_1181 227 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 146329520 Common fld flavodoxin DNO_1297 65 COG0716 FldA, Flavodoxins Energy production and conversion 146328681 Common rplY 50S ribosomal protein L25 DNO_0064 194 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 146329451 Common priA primosomal protein N' DNO_0356 211 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 146328820 Common ostA organic solvent tolerance protein DNO_0920 118 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 146329680 Pathogen - hypothetical protein DNO_0741 1 None None None 146329273 Common gcvH glycine cleavage system protein H DNO_1070 185 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 146329472 Common - multidrug efflux protein DNO_0787 176 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 146329014 Pathogen - hypothetical protein DNO_1194 1 None None None 146329482 Common intA1 integrase A1 DNO_0282 110 None None None 146329550 Common - PpiC-type peptidylprolyl cis-trans isomerase DNO_0921 133 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 146328845 Common valS valyl-tRNA synthetase DNO_0351 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146329646 Pathogen - hypothetical lipoprotein DNO_0615 1 None None None 146329656 Common tmk thymidylate kinase DNO_1213 227 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 146329334 Common - ABC transporter family protein DNO_0046 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 146329507 Pathogen - preprotein translocase, SecG subunit DNO_0813 1 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 146329243 Common dksA RNA polymerase-binding protein DksA DNO_0353 157 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 146329343 Common rnfG electron transport complex protein, G subunit DNO_0551 56 COG4659 RnfG, Predicted NADH:ubiquinone oxidoreductase, subunit RnfG Energy production and conversion 146329698 Common sufB FeS assembly protein SufB DNO_0837 184 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 146329620 Common feoA iron transport protein FeoA DNO_0136 53 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 146329124 Common - hypothetical protein DNO_1013 118 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 146329784 Common - conserved hypothetical lipoprotein DNO_1115 26 COG3317 NlpB, Uncharacterized lipoprotein Cell envelope biogenesis, outer membrane 146329511 Common - conserved hypothetical lipoprotein DNO_0873 59 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 146329895 Common - hypothetical protein DNO_0935 165 COG1576 COG1576, Uncharacterized conserved protein Function unknown 146328788 Common - LemA family protein DNO_0794 131 COG1704 LemA, Uncharacterized conserved protein Function unknown 146328734 Common - hypothetical protein DNO_0860 107 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 146329846 Common fumC fumarate hydratase, class II DNO_0506 237 COG0114 FumC, Fumarase Energy production and conversion 146328684 Common glpF major intrinsic protein superfamily, glycerol facilitator protein DNO_0214 131 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 146329712 Common - potassium/proton antiporter DNO_1157 161 COG3263 COG3263, NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain Inorganic ion transport and metabolism 146328673 Common - lytic murein transglycosylase family protein DNO_1086 105 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 146329673 Common fur ferric uptake regulator DNO_0877 192 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 146329339 Common - phage virion morphogenesis-like protein DNO_0750 7 COG5005 COG5005, Mu-like prophage protein gpG General function prediction only 146329155 Common yfeD ABC iron transporter permease YfeD DNO_0640 171 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 146329456 Common - hypothetical protein DNO_1328 15 COG4517 COG4517, Uncharacterized protein conserved in bacteria Function unknown 146328929 Pathogen - hypothetical protein DNO_0057 1 None None None 146329563 Common - toluene tolerance family protein DNO_0856 49 COG2854 Ttg2D, ABC-type transport system involved in resistance to organic solvents, auxiliary component Secondary metabolites biosynthesis, transport, and catabolism 146328789 Pathogen - hypothetical protein DNO_0660 1 None None None 146329881 Pathogen - hypothetical protein DNO_1164 1 None None None 146329314 Common - transposase, IS605 family DNO_0387 69 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 146329292 Common - hypothetical protein DNO_0399 140 COG1660 COG1660, Predicted P-loop-containing kinase General function prediction only 146328973 Common maf-1 Maf-like protein DNO_0492 193 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 146328972 Common - GTP binding domain protein DNO_0488 249 COG0536 Obg, Predicted GTPase General function prediction only 146329461 Common - zinc-binding dehydrogenase family protein DNO_0367 109 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 146328717 Common - FAD dependent oxidoreductase family protein DNO_0212 150 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 146329540 Common - histidine triad (HIT) domain protein DNO_1299 205 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 146329029 Common vapC1 virulence-associated protein VapC1 DNO_0277 62 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 146329408 Common glmU UDP-N-acetylglucosamine pyrophosphorylase DNO_1140 232 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 146328936 Common - NUDIX hydrolase domain protein DNO_0844 19 None None None 146329195 Common vrlI conserved hypothetical protein VrlI DNO_0183 20 None None None 146329724 Pathogen - hypothetical protein DNO_0270 1 None None None 146328979 Common radA DNA repair protein RadA DNO_0326 214 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 146329744 Common birA biotin-acetyl-CoA-carboxylase ligase DNO_0541 184 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 146329636 Common orn oligoribonuclease DNO_0904 88 COG1949 Orn, Oligoribonuclease (3'->5' exoribonuclease) RNA processing and modification 146329607 Common rluB ribosomal large subunit pseudouridine synthase, RluB DNO_0479 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 146329401 Common psd phosphatidylserine decarboxylase DNO_1101 98 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 146329813 Common - hypothetical protein DNO_0820 79 COG1738 COG1738, Uncharacterized conserved protein Function unknown 146328668 Common bprV basic extracellular subtilisin-like protease precursor BprV DNO_0605 125 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 146329121 Common fimN type IV fimbrial biogenesis nucleotide binding protein FimN DNO_1126 197 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 146329809 Common ssb-1 single-strand binding protein DNO_0126 213 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 146329769 Common - lysyl-RNA synthetase DNO_0604 208 COG2269 COG2269, Truncated, possibly inactive, lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 146328767 Common coaE dephospho-CoA kinase DNO_1122 207 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 146329800 Common intA2 integrase A2 DNO_1045 110 None None None 146328721 Common - methyltransferase family protein DNO_0481 64 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 146329148 Common fba fructose-bisphosphate aldolase DNO_0166 166 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 146328760 Common - bacterial extracellular solute-binding fmaily protein DNO_0994 156 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 146329041 Pathogen - hypothetical protein DNO_0430 1 None None None 146329811 Common - calcium binding domain protein DNO_0235 25 COG2931 COG2931, RTX toxins and related Ca2+-binding proteins Secondary metabolites biosynthesis, transport, and catabolism 146329363 Common purM phosphoribosylformylglycinamidine cyclo-ligase DNO_1113 232 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 146329175 Common glyS glycyl-tRNA synthetase, beta subunit DNO_0702 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 146329522 Pathogen - hypothetical protein DNO_0562 1 None None None 146328884 Common tyrS tyrosyl-tRNA synthetase DNO_1321 240 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146328778 Common rplW 50S ribosomal protein L23 DNO_1273 210 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 146328924 Common aspA aspartate ammonia-lyase DNO_0874 236 COG1027 AspA, Aspartate ammonia-lyase Amino acid transport and metabolism 146329117 Common nusG transcription termination-antitermination factor NusG DNO_1287 215 COG0250 NusG, Transcription antiterminator Transcription 146329255 Common aroB 3-dehydroquinate synthase DNO_1084 207 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 146328654 Common - hypothetical protein DNO_0847 24 None None None 146329434 Common lgt prolipoprotein diacylglyceryl transferase DNO_0568 200 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 146328983 Common - hypothetical protein DNO_0801 61 COG2128 COG2128, Uncharacterized conserved protein Function unknown 146329900 Common vapA2 virulence-associated protein VapA2 DNO_0271 62 COG3093 VapI, Plasmid maintenance system antidote protein General function prediction only 146328694 Common - hypothetical protein DNO_0440 3 COG3165 COG3165, Uncharacterized protein conserved in bacteria Function unknown 146328960 Common trxB thioredoxin reductase DNO_1099 248 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 146329529 Common ftsW cell division protein FtsW DNO_0982 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 146329071 Common - hypothetical protein DNO_0240 80 COG4121 COG4121, Uncharacterized conserved protein Function unknown 146329232 Common - competence family protein DNO_0330 15 COG0658 ComEC, Predicted membrane metal-binding protein General function prediction only 146329795 Common grpE co-chaperone GrpE DNO_0825 230 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 146329793 Pathogen - hypothetical membrane protein DNO_0589 1 None None None 146329764 Common - hypothetical protein DNO_0403 2 COG3087 FtsN, Cell division protein Cell division and chromosome partitioning 146329442 Common rplI 50S ribosomal protein L9 DNO_1119 216 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis