Metallosphaera sedula DSM 5348, complete genome NC_009440 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 146303953 Nonpathogen - PilT protein domain protein Msed_1184 1 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 146304941 Nonpathogen - hypothetical protein Msed_2194 1 None None None 146304608 Nonpathogen - transcription termination factor Tfs Msed_1860 33 COG1594 RPB9, DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS Transcription 146303812 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Msed_1039 101 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 146303799 Common - ATPase associated with various cellular activities, AAA_5 Msed_1023 19 COG0714 COG0714, MoxR-like ATPases General function prediction only 146304319 Common - histone deacetylase superfamily Msed_1556 160 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 146304663 Nonpathogen - Vacuolar H+-transporting two-sector ATPase, F subunit Msed_1915 6 COG1436 NtpG, Archaeal/vacuolar-type H+-ATPase subunit F Energy production and conversion 146302996 Nonpathogen - hypothetical protein Msed_0211 3 None None None 146304101 Nonpathogen - CopG domain protein DNA-binding domain protein Msed_1335 1 None None None 146304386 Common - nicotinate phosphoribosyltransferase Msed_1623 113 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 146304416 Common pgk phosphoglycerate kinase Msed_1653 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 146303065 Common - putative signal-transduction protein with CBS domains Msed_0280 199 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 146304827 Nonpathogen - hypothetical protein Msed_2079 2 None None None 146304486 Nonpathogen - fibrillarin Msed_1723 34 COG1889 NOP1, Fibrillarin-like rRNA methylase Translation, ribosomal structure and biogenesis 146303096 Nonpathogen - hypothetical protein Msed_0311 1 None None None 146304203 Nonpathogen - transcriptional regulator, TrmB Msed_1438 2 COG3355 COG3355, Predicted transcriptional regulator Transcription 146303080 Common - protein of unknown function DUF224, cysteine-rich region domain protein Msed_0295 143 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 146303465 Nonpathogen - hypothetical protein Msed_0682 2 None None None 146303235 Nonpathogen - protein of unknown function DUF1291 Msed_0450 7 COG3370 COG3370, Uncharacterized protein conserved in archaea Function unknown 146304214 Common - phosphoribosylaminoimidazole carboxylase ATPase subunit Msed_1449 193 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 146303695 Common - (NiFe) hydrogenase maturation protein HypF Msed_0915 114 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 146302845 Nonpathogen - hypothetical protein Msed_0060 1 None None None 146304652 Common - Myo-inositol-1-phosphate synthase Msed_1904 50 COG1260 INO1, Myo-inositol-1-phosphate synthase Lipid metabolism 146304536 Nonpathogen - Bacterio-opsin activator, HTH domain protein Msed_1773 10 COG3413 COG3413, Predicted DNA binding protein General function prediction only 146304787 Nonpathogen - AAA ATPase Msed_2039 2 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 146303729 Nonpathogen - hypothetical protein Msed_0949 1 None None None 146302836 Nonpathogen - hypothetical protein Msed_0051 22 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 146304056 Common - extracellular solute-binding protein, family 1 Msed_1289 32 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 146303140 Common - ATPase-like protein Msed_0355 77 COG0433 COG0433, Predicted ATPase General function prediction only 146304510 Nonpathogen - chromatin protein Msed_1747 28 COG1581 Ssh10b, Archaeal DNA-binding protein Transcription 146302923 Nonpathogen - zinc finger, SWIM domain protein Msed_0138 2 None None None 146304920 Common - ATPase involved in chromosome partitioning-like protein Msed_2173 229 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146303188 Common - peptidase U62, modulator of DNA gyrase Msed_0403 167 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 146303600 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Msed_0817 12 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 146303130 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase Msed_0345 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 146303296 Common - beta-lactamase domain protein Msed_0513 75 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 146304630 Nonpathogen - hypothetical protein Msed_1882 2 None None None 146302948 Nonpathogen - hypothetical protein Msed_0163 2 None None None 146303120 Common - von Willebrand factor, type A Msed_0335 12 COG4245 TerY, Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain General function prediction only 146304648 Nonpathogen - NADH-ubiquinone/plastoquinone oxidoreductase, chain 6 Msed_1900 8 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 146303285 Common - Rieske (2Fe-2S) domain protein Msed_0501 15 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 146304295 Common - protein of unknown function DUF6, transmembrane Msed_1531 133 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 146303790 Nonpathogen - hypothetical protein Msed_1014 4 None None None 146304590 Common - glycosyl transferase, group 1 Msed_1832 31 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 146303681 Nonpathogen - hypothetical protein Msed_0901 2 None None None 146303440 Common - RNA modification enzyme, MiaB family Msed_0657 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 146304192 Common - Alcohol dehydrogenase GroES domain protein Msed_1426 207 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 146303356 Common leuS leucyl-tRNA synthetase Msed_0573 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146304456 Common - Myo-inositol-1-phosphate synthase Msed_1693 61 COG1260 INO1, Myo-inositol-1-phosphate synthase Lipid metabolism 146303898 Common - 5-oxoprolinase (ATP-hydrolyzing) Msed_1128 95 COG0146 HyuB, N-methylhydantoinase B/acetone carboxylase, alpha subunit Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 146304237 Common - coenzyme A transferase Msed_1472 46 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 146303172 Common - protein of unknown function DUF35 Msed_0387 47 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 146303314 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Msed_0531 176 COG0388 COG0388, Predicted amidohydrolase General function prediction only 146303407 Nonpathogen - protein of unknown function DUF115 Msed_0624 29 COG1634 COG1634, Uncharacterized Rossmann fold enzyme General function prediction only 146303889 Common - D-lactate dehydrogenase (cytochrome) Msed_1118 201 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 146304291 Common - isochorismatase hydrolase Msed_1527 160 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 146304229 Nonpathogen - hypothetical protein Msed_1464 4 None None None 146303368 Common - protein of unknown function DUF125, transmembrane Msed_0585 80 COG1814 COG1814, Uncharacterized membrane protein Function unknown 146304183 Common - Starch synthase Msed_1417 208 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 146303946 Common - FAD dependent oxidoreductase Msed_1177 168 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 146304953 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Msed_2207 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 146304814 Common - Uncharacterized membrane-associated protein-like protein Msed_2066 150 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 146304841 Common - ABC-type Fe3+-hydroxamate transport system periplasmic component-like protein Msed_2093 93 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 146304918 Nonpathogen - hypothetical protein Msed_2171 2 None None None 146304780 Common - cytochrome c oxidase, subunit I Msed_2032 175 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 146303495 Common - methionine sulfoxide reductase A Msed_0712 205 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 146303987 Common - acyl-CoA dehydrogenase domain protein Msed_1218 152 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 146303038 Common - UspA domain protein Msed_0253 110 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 146303882 Common - DNA binding domain, excisionase family Msed_1111 31 COG2452 COG2452, Predicted site-specific integrase-resolvase DNA replication, recombination, and repair 146304820 Common - short-chain dehydrogenase/reductase SDR Msed_2072 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 146304041 Nonpathogen - hypothetical protein Msed_1273 1 None None None 146304882 Common - Geranyltranstransferase Msed_2135 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 146303198 Nonpathogen - hypothetical protein Msed_0413 2 None None None 146304028 Nonpathogen - hypothetical protein Msed_1260 1 None None None 146304872 Common - beta-lactamase domain protein Msed_2125 124 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 146303048 Nonpathogen - DoxX family protein Msed_0263 2 COG2259 COG2259, Predicted membrane protein Function unknown 146303426 Nonpathogen - carbon monoxide dehydrogenase subunit G Msed_0643 2 COG3427 COG3427, Uncharacterized conserved protein Function unknown 146304617 Common - Rieske (2Fe-2S) domain protein Msed_1869 26 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 146304365 Common - mevalonate kinase Msed_1602 53 COG1577 ERG12, Mevalonate kinase Lipid metabolism 146304097 Nonpathogen - hypothetical protein Msed_1331 2 None None None 146304149 Common - von Willebrand factor, type A Msed_1383 40 COG2304 COG2304, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 146304548 Common - 2'-5' RNA ligase Msed_1785 108 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 146302979 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Msed_0194 116 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 146303430 Common - metal dependent phosphohydrolase Msed_0647 30 COG1896 COG1896, Predicted hydrolases of HD superfamily General function prediction only 146303050 Common - transcriptional regulator, HxlR family Msed_0265 84 COG1733 COG1733, Predicted transcriptional regulators Transcription 146303524 Common - major facilitator superfamily MFS_1 Msed_0741 7 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 146303956 Nonpathogen - hypothetical protein Msed_1187 3 None None None 146304597 Common - methyltransferase FkbM family Msed_1846 25 COG2263 COG2263, Predicted RNA methylase Translation, ribosomal structure and biogenesis 146305034 Nonpathogen - hypothetical protein Msed_2289 1 None None None 146303702 Nonpathogen - hypothetical protein Msed_0922 1 None None None 146304273 Common - Radical SAM domain protein Msed_1508 87 COG2516 COG2516, Biotin synthase-related enzyme General function prediction only 146302982 Common - cobalamin biosynthesis protein CobD Msed_0197 142 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 146304819 Common - phage SPO1 DNA polymerase-related protein Msed_2071 154 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 146303412 Nonpathogen - 6-pyruvoyl tetrahydropterin synthase and hypothetical protein Msed_0629 2 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 146303651 Nonpathogen - ABC-2 type transporter Msed_0870 13 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 146305000 Common - beta-lactamase domain protein Msed_2254 160 COG1782 COG1782, Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain General function prediction only 146303931 Nonpathogen - protein of unknown function DUF324 Msed_1162 5 COG1337 COG1337, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 146302876 Common rpl3p 50S ribosomal protein L3P Msed_0091 121 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 146303919 Nonpathogen - CRISPR-associated protein Cas4 Msed_1150 5 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 146303395 Nonpathogen - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Msed_0612 8 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 146303073 Common - Rieske (2Fe-2S) domain protein Msed_0288 19 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 146304848 Common - Fmu (Sun) domain protein Msed_2100 180 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 146304601 Nonpathogen - hypothetical protein Msed_1853 1 None None None 146304151 Nonpathogen - PilT protein domain protein Msed_1385 4 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 146304659 Common - CDP-alcohol phosphatidyltransferase Msed_1911 36 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 146304579 Common - hypothetical protein Msed_1817 16 None None None 146303544 Common - metallophosphoesterase Msed_0761 65 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 146303533 Common - phosphoribosyltransferase Msed_0750 67 COG2236 COG2236, Predicted phosphoribosyltransferases General function prediction only 146303374 Nonpathogen - hypothetical protein Msed_0591 2 COG2512 COG2512, Uncharacterized membrane-associated protein/domain Function unknown 146304392 Nonpathogen rplX 50S ribosomal protein LX Msed_1629 12 COG2157 RPL20A, Ribosomal protein L20A (L18A) Translation, ribosomal structure and biogenesis 146303840 Common - ABC transporter related Msed_1068 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 146304736 Common - argininosuccinate lyase Msed_1988 217 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 146302922 Nonpathogen - hypothetical protein Msed_0137 2 COG3355 COG3355, Predicted transcriptional regulator Transcription 146304946 Nonpathogen - hypothetical protein Msed_2199 4 None None None 146303657 Nonpathogen - hypothetical protein Msed_0877 2 None None None 146303615 Nonpathogen - putative transcriptional regulator, AsnC family Msed_0832 4 COG1522 Lrp, Transcriptional regulators Transcription 146304060 Common - heat shock protein Hsp20 Msed_1294 57 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 146304066 Common - peptidase S9, prolyl oligopeptidase active site domain protein Msed_1300 111 COG1505 COG1505, Serine proteases of the peptidase family S9A Amino acid transport and metabolism 146304131 Common - dual specificity protein phosphatase Msed_1365 30 COG2453 CDC14, Predicted protein-tyrosine phosphatase Signal transduction mechanisms 146303557 Nonpathogen - hypothetical protein Msed_0774 27 COG1650 COG1650, Uncharacterized protein conserved in archaea Function unknown 146303403 Nonpathogen - hypothetical protein Msed_0620 4 None None None 146304704 Common - putative transcriptional regulator, AsnC family Msed_1956 119 COG1522 Lrp, Transcriptional regulators Transcription 146303248 Common - major facilitator superfamily MFS_1 Msed_0463 143 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146304199 Common - exodeoxyribonuclease III Xth Msed_1434 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 146303416 Common - inositol monophosphatase Msed_0633 163 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 146303111 Nonpathogen - protein of unknown function DUF1404 Msed_0326 2 None None None 146304776 Nonpathogen - transcriptional regulator, AbrB family Msed_2028 4 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 146304374 Common folE GTP cyclohydrolase I Msed_1611 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 146303905 Common - photosystem I assembly BtpA Msed_1136 41 COG0434 SgcQ, Predicted TIM-barrel enzyme General function prediction only 146304748 Nonpathogen - hypothetical protein Msed_2000 2 None None None 146304015 Nonpathogen - hypothetical protein Msed_1247 2 None None None 146304353 Common - glycosyl transferase, group 1 Msed_1590 194 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 146304150 Nonpathogen - hypothetical protein Msed_1384 6 None None None 146303436 Nonpathogen - KH, type 1, domain protein Msed_0653 33 COG1094 COG1094, Predicted RNA-binding protein (contains KH domains) General function prediction only 146303000 Common - delta-aminolevulinic acid dehydratase Msed_0215 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 146304929 Common - aminotransferase, class I and II Msed_2182 206 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 146302904 Nonpathogen - hypothetical protein Msed_0119 5 None None None 146304835 Common - acyl-CoA dehydrogenase domain protein Msed_2087 165 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 146302812 Nonpathogen rps28e 30S ribosomal protein S28e Msed_0027 33 COG2053 RPS28A, Ribosomal protein S28E/S33 Translation, ribosomal structure and biogenesis 146304051 Common - Radical SAM domain protein Msed_1284 37 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 146303658 Common - transglutaminase, N-terminal domain protein Msed_0878 96 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 146303444 Common - ribonuclease HII Msed_0661 237 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 146304177 Common - GCN5-related N-acetyltransferase Msed_1411 68 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 146304468 Common - ATP-NAD/AcoX kinase Msed_1705 26 COG3199 COG3199, Uncharacterized conserved protein Function unknown 146304873 Common - methionine aminopeptidase Msed_2126 243 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 146303715 Common - amino acid permease-associated region Msed_0935 129 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146303138 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Msed_0353 113 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 146303393 Common - (2Fe-2S)-binding domain protein Msed_0610 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 146304371 Nonpathogen - Mn2+-dependent serine/threonine protein kinase Msed_1608 7 COG3642 COG3642, Mn2+-dependent serine/threonine protein kinase Signal transduction mechanisms 146304122 Nonpathogen - hypothetical protein Msed_1356 3 None None None 146303453 Nonpathogen - hypothetical protein Msed_0670 3 None None None 146302955 Common - acetyl-lysine deacetylase Msed_0170 118 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 146304180 Common - FAD dependent oxidoreductase Msed_1414 40 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 146303189 Nonpathogen - hypothetical protein Msed_0404 2 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146303270 Common - cytochrome c oxidase, subunit I Msed_0485 174 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 146304958 Common - putative agmatinase Msed_2212 148 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 146304903 Nonpathogen - putative translation factor pelota Msed_2156 34 COG1537 PelA, Predicted RNA-binding proteins General function prediction only 146304212 Common - amino acid permease-associated region Msed_1447 33 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146303486 Common - isocitrate dehydrogenase Msed_0703 222 COG0538 Icd, Isocitrate dehydrogenases Energy production and conversion 146305009 Common - ATPase-like protein Msed_2263 99 COG0433 COG0433, Predicted ATPase General function prediction only 146304402 Nonpathogen - protein of unknown function DUF434 Msed_1639 14 COG2454 COG2454, Uncharacterized conserved protein Function unknown 146304857 Common - DNA-(apurinic or apyrimidinic site) lyase Msed_2110 238 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 146303507 Common - NUDIX hydrolase Msed_0724 187 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 146303094 Common - pyruvate ferredoxin oxidoreductase subunit beta Msed_0309 125 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 146304607 Nonpathogen - hypothetical protein Msed_1859 2 None None None 146303354 Nonpathogen - conserved hypothetical selenoprotein Msed_0571 8 COG3526 COG3526, Uncharacterized protein conserved in bacteria Posttranslational modification, protein turnover, chaperones 146303871 Nonpathogen - hypothetical protein Msed_1099 5 None None None 146302892 Common rpl6p 50S ribosomal protein L6P Msed_0107 46 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 146304746 Nonpathogen - protein of unknown function DUF309 Msed_1998 6 COG1547 COG1547, Uncharacterized conserved protein Function unknown 146302806 Common - hypothetical protein Msed_0021 170 COG1985 RibD, Pyrimidine reductase, riboflavin biosynthesis Coenzyme metabolism 146302881 Common rpl22p 50S ribosomal protein L22P Msed_0096 153 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 146304765 Nonpathogen - hypothetical protein Msed_2017 2 None None None 146304611 Nonpathogen - exosome complex RNA-binding protein Csl4 Msed_1863 22 COG1096 COG1096, Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain) Translation, ribosomal structure and biogenesis 146304666 Common - V-type ATP synthase subunit B Msed_1918 247 COG1156 NtpB, Archaeal/vacuolar-type H+-ATPase subunit B Energy production and conversion 146303625 Nonpathogen - hypothetical protein Msed_0843 1 None None None 146304629 Nonpathogen - hypothetical protein Msed_1881 2 None None None 146304963 Nonpathogen - tRNA-splicing endonuclease subunit alpha Msed_2217 33 COG1676 SEN2, tRNA splicing endonuclease Translation, ribosomal structure and biogenesis 146304671 Common - pyridoxine biosynthesis protein Msed_1923 87 COG0214 SNZ1, Pyridoxine biosynthesis enzyme Coenzyme metabolism 146303576 Nonpathogen - twin-arginine translocation protein, TatA/E family subunit Msed_0793 4 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 146304463 Common - aspartate-semialdehyde dehydrogenase Msed_1700 207 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 146304694 Common - imidazoleglycerol phosphate synthase, cyclase subunit Msed_1946 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 146303839 Common - major facilitator superfamily MFS_1 Msed_1067 21 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146304190 Common - Alcohol dehydrogenase, zinc-binding domain protein Msed_1424 215 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 146304133 Nonpathogen - hypothetical protein Msed_1367 2 None None None 146304333 Common - glycine cleavage H-protein Msed_1570 172 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 146304852 Common - type II secretion system protein E Msed_2104 226 COG0630 VirB11, Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis Cell motility and secretion / Intracellular trafficking and secretion 146303209 Nonpathogen - hypothetical protein Msed_0424 2 COG3971 COG3971, 2-keto-4-pentenoate hydratase Secondary metabolites biosynthesis, transport, and catabolism 146304476 Nonpathogen - hypothetical protein Msed_1713 5 None None None 146304581 Common - amino acid permease-associated region Msed_1819 52 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146303168 Nonpathogen - hypothetical protein Msed_0383 3 None None None 146304308 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Msed_1545 64 COG1148 HdrA, Heterodisulfide reductase, subunit A and related polyferredoxins Energy production and conversion 146304994 Common - methionine synthase Msed_2248 149 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 146304451 Common - N-(5'phosphoribosyl)anthranilate isomerase (PRAI) Msed_1688 70 COG0135 TrpF, Phosphoribosylanthranilate isomerase Amino acid transport and metabolism 146304185 Common - Nucleotidyl transferase Msed_1419 234 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 146304734 Nonpathogen - hypothetical protein Msed_1986 1 None None None 146303159 Nonpathogen - TQO small subunit DoxD Msed_0374 3 COG2259 COG2259, Predicted membrane protein Function unknown 146303381 Common - DNA polymerase IV Msed_0598 185 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 146304951 Common - binding-protein-dependent transport systems inner membrane component Msed_2205 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 146303173 Common - Phenylacetate--CoA ligase Msed_0388 113 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 146304911 Common - protein of unknown function DUF87 Msed_2164 36 COG0433 COG0433, Predicted ATPase General function prediction only 146304988 Nonpathogen - PilT protein domain protein Msed_2242 4 COG1412 COG1412, Uncharacterized proteins of PilT N-term./Vapc superfamily General function prediction only 146303279 Nonpathogen - DNA polymerase, beta domain protein region Msed_0494 4 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 146304624 Common - 3-deoxy-7-phosphoheptulonate synthase Msed_1876 184 COG2876 AroA, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 146303020 Nonpathogen - hypothetical protein Msed_0235 2 None None None 146303075 Common - Cytochrome-c oxidase Msed_0290 168 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 146303974 Nonpathogen - hypothetical protein Msed_1205 1 None None None 146303154 Common - beta-lactamase domain protein Msed_0369 215 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 146304075 Common - glutamine amidotransferase class-I Msed_1309 115 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 146303129 Common - Carboxypeptidase Taq Msed_0344 82 COG2317 COG2317, Zn-dependent carboxypeptidase Amino acid transport and metabolism 146303587 Common - Pyrrolo-quinoline quinone Msed_0804 37 COG1520 COG1520, FOG: WD40-like repeat Function unknown 146303866 Common - major facilitator superfamily MFS_1 Msed_1094 180 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 146303046 Nonpathogen - hypothetical protein Msed_0261 2 None None None 146303755 Nonpathogen - hypothetical protein Msed_0978 2 None None None 146303105 Common - cytochrome c oxidase, subunit II Msed_0320 143 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 146303118 Common - FAD dependent oxidoreductase Msed_0333 68 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 146303254 Nonpathogen - hypothetical protein Msed_0469 20 COG0348 NapH, Polyferredoxin Energy production and conversion 146303386 Nonpathogen - protein of unknown function Met10 Msed_0603 35 COG2520 COG2520, Predicted methyltransferase General function prediction only 146304264 Nonpathogen - protein of unknown function DUF929 Msed_1499 3 None None None 146303724 Common - Nickel-iron dehydrogenase small subunit, N-terminal domain protein Msed_0944 75 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 146303379 Common - TIP49-like protein Msed_0596 26 COG1224 TIP49, DNA helicase TIP49, TBP-interacting protein Transcription 146304646 Common - NADH dehydrogenase subunit H Msed_1898 185 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 146304248 Common - sugar fermentation stimulation protein A Msed_1483 100 COG1489 SfsA, DNA-binding protein, stimulates sugar fermentation General function prediction only 146303859 Nonpathogen - protein of unknown function DUF929 Msed_1087 3 None None None 146303195 Nonpathogen - hypothetical protein Msed_0410 1 None None None 146303944 Common - thiamine pyrophosphate enzyme domain protein TPP-binding Msed_1175 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 146304019 Common - putative signal-transduction protein with CBS domains Msed_1251 104 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 146304577 Nonpathogen - hypothetical protein Msed_1815 2 None None None 146303963 Nonpathogen - hypothetical protein Msed_1194 1 None None None 146303779 Common - Methyltransferase type 11 Msed_1003 50 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 146303537 Nonpathogen - hypothetical protein Msed_0754 10 None None None 146303326 Common - molybdenum cofactor synthesis domain Msed_0543 189 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 146304887 Common rps2P 30S ribosomal protein S2 Msed_2140 129 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 146302941 Nonpathogen - hypothetical protein Msed_0156 2 None None None 146304088 Common - glycoside hydrolase 15-related Msed_1322 72 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 146304860 Common - DEAD/H associated domain protein Msed_2113 159 COG1201 Lhr, Lhr-like helicases General function prediction only 146304164 Nonpathogen - hypothetical protein Msed_1398 2 COG2522 COG2522, Predicted transcriptional regulator General function prediction only 146304890 Common rpl13p 50S ribosomal protein L13P Msed_2143 122 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 146302853 Common - Nucleotidyl transferase Msed_0068 240 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 146303916 Common - CRISPR-associated protein Cas1 Msed_1147 96 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 146304899 Common - tyrosyl-tRNA synthetase Msed_2152 146 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146303768 Nonpathogen - Bacterio-opsin activator, HTH domain protein Msed_0992 3 COG3413 COG3413, Predicted DNA binding protein General function prediction only 146302866 Nonpathogen - hypothetical protein Msed_0081 2 None None None 146304427 Common - glycine dehydrogenase subunit 1 Msed_1664 172 COG0403 GcvP, Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain Amino acid transport and metabolism 146304716 Common - phosphate uptake regulator, PhoU Msed_1968 37 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 146303245 Common - hypothetical protein Msed_0460 8 None None None 146303736 Nonpathogen - hypothetical protein Msed_0957 2 None None None 146302826 Common - elongation factor 1-alpha Msed_0041 249 COG5256 TEF1, Translation elongation factor EF-1alpha (GTPase) Translation, ribosomal structure and biogenesis 146304558 Nonpathogen - hypothetical protein Msed_1795 3 None None None 146303666 Nonpathogen - hypothetical protein Msed_0886 2 COG2371 UreE, Urease accessory protein UreE Posttranslational modification, protein turnover, chaperones 146304110 Nonpathogen - hypothetical protein Msed_1344 2 None None None 146303784 Common - Acetyl-CoA acetyltransferase-like protein Msed_1008 90 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 146303089 Nonpathogen - hypothetical protein Msed_0304 2 None None None 146304759 Common - Sua5/YciO/YrdC/YwlC family protein Msed_2011 239 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 146304634 Nonpathogen - hypothetical protein Msed_1886 2 None None None 146304880 Nonpathogen - hypothetical protein Msed_2133 1 None None None 146303727 Common - Fe-S oxidoreductase-like protein Msed_0947 58 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 146304908 Common - lysyl-tRNA synthetase Msed_2161 248 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 146304932 Common - transposase, IS605 OrfB family Msed_2185 30 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 146303609 Nonpathogen - hypothetical protein Msed_0826 2 COG4454 COG4454, Uncharacterized copper-binding protein Inorganic ion transport and metabolism 146302962 Nonpathogen - hypothetical protein Msed_0177 2 None None None 146303340 Common - hypothetical protein Msed_0557 30 None None None 146303756 Common - Thymidylate kinase-like protein Msed_0979 31 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 146304447 Common - aspartate aminotransferase Msed_1684 242 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 146304938 Nonpathogen - hypothetical protein Msed_2191 1 None None None 146303647 Common - General substrate transporter Msed_0866 109 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 146304562 Common - ornithine cyclodeaminase/mu-crystallin Msed_1799 83 COG2423 COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog Amino acid transport and metabolism 146303302 Common - hypothetical protein Msed_0519 6 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146304430 Nonpathogen - hypothetical protein Msed_1667 6 None None None 146303321 Nonpathogen - hypothetical protein Msed_0538 2 None None None 146304081 Nonpathogen - hypothetical protein Msed_1315 1 None None None 146304283 Nonpathogen - hypothetical protein Msed_1519 1 None None None 146303800 Nonpathogen - hypothetical protein Msed_1024 6 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 146304685 Nonpathogen - protein of unknown function DUF211 Msed_1937 23 COG1888 COG1888, Uncharacterized protein conserved in archaea Function unknown 146303566 Common - hypothetical protein Msed_0783 12 COG4911 COG4911, Uncharacterized conserved protein Function unknown 146304792 Nonpathogen - protein of unknown function DUF1288 Msed_2044 5 None None None 146304728 Common - phosphoribosylformylglycinamidine synthase II Msed_1980 235 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 146304750 Common ubiA prenyltransferase Msed_2002 162 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 146303202 Nonpathogen - major facilitator superfamily MFS_1 Msed_0417 9 None None None 146303998 Nonpathogen - hypothetical protein Msed_1229 3 None None None 146302799 Common - FAD dependent oxidoreductase Msed_0014 83 COG2509 COG2509, Uncharacterized FAD-dependent dehydrogenases General function prediction only 146304511 Common - reverse gyrase Msed_1748 232 COG1110 COG1110, Reverse gyrase DNA replication, recombination, and repair 146303980 Nonpathogen - hypothetical protein Msed_1211 3 None None None 146304368 Common - peroxiredoxins-like protein Msed_1605 9 COG2044 COG2044, Predicted peroxiredoxins General function prediction only 146303349 Common - Enoyl-CoA hydratase/isomerase Msed_0566 144 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 146303316 Common - histone deacetylase superfamily Msed_0533 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 146304043 Common - 40-residue YVTN family beta-propeller repeat protein Msed_1275 47 COG3391 COG3391, Uncharacterized conserved protein Function unknown 146303546 Nonpathogen - hypothetical protein Msed_0763 9 COG1630 COG1630, Uncharacterized protein conserved in archaea Function unknown 146303692 Common - glycoside hydrolase, family 13 domain protein Msed_0912 88 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 146303031 Common - protein of unknown function DUF699, ATPase putative Msed_0246 48 COG1444 COG1444, Predicted P-loop ATPase fused to an acetyltransferase General function prediction only 146304269 Nonpathogen - protein of unknown function DUF1286 Msed_1504 4 None None None 146303077 Nonpathogen - protein of unknown function DUF1404 Msed_0292 2 None None None 146304235 Nonpathogen - hypothetical protein Msed_1470 2 None None None 146304974 Nonpathogen - hypothetical protein Msed_2228 3 None None None 146304293 Common - hypothetical protein Msed_1529 29 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 146303896 Common - transcriptional regulator, GntR family Msed_1126 141 COG1802 GntR, Transcriptional regulators Transcription 146304948 Nonpathogen - hypothetical protein Msed_2202 2 None None None 146304458 Nonpathogen - Snf7 Msed_1695 7 COG5491 VPS24, Conserved protein implicated in secretion Cell motility and secretion 146304340 Common - metal dependent phosphohydrolase Msed_1577 88 COG1078 COG1078, HD superfamily phosphohydrolases General function prediction only 146303067 Nonpathogen - hypothetical protein Msed_0282 1 None None None 146304822 Common - Glu/Leu/Phe/Val dehydrogenase, C terminal Msed_2074 180 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 146304270 Nonpathogen - hypothetical protein Msed_1505 4 COG1673 COG1673, Uncharacterized protein conserved in archaea Function unknown 146304312 Common - hypothetical protein Msed_1549 43 COG2210 COG2210, Uncharacterized conserved protein Function unknown 146304394 Common - signal recognition particle-docking protein FtsY Msed_1631 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 146303948 Common - binding-protein-dependent transport systems inner membrane component Msed_1179 131 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 146304523 Common - glycosyl transferase, group 1 Msed_1760 168 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 146304143 Common - ABC transporter related Msed_1377 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 146304546 Nonpathogen - Ser/Thr protein kinase-like protein Msed_1783 9 COG2112 COG2112, Predicted Ser/Thr protein kinase Signal transduction mechanisms 146304232 Common - aconitate hydratase Msed_1467 223 COG1048 AcnA, Aconitase A Energy production and conversion 146302911 Nonpathogen - triphosphoribosyl-dephospho-CoA protein Msed_0126 18 COG1767 CitG, Triphosphoribosyl-dephospho-CoA synthetase Coenzyme metabolism 146305027 Nonpathogen - RecB-family nuclease-like protein Msed_2281 12 COG4080 COG4080, RecB-family nuclease DNA replication, recombination, and repair 146303827 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) Msed_1054 202 COG0281 SfcA, Malic enzyme Energy production and conversion 146304255 Common - FHA domain containing protein Msed_1490 28 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 146303014 Nonpathogen - regulatory protein, ArsR Msed_0229 6 COG4189 COG4189, Predicted transcriptional regulator Transcription 146304870 Common pheT phenylalanyl-tRNA synthetase subunit beta Msed_2123 208 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 146303559 Common - thioredoxin Msed_0776 233 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 146304481 Nonpathogen - hypothetical protein Msed_1718 2 None None None 146304099 Nonpathogen - hypothetical protein Msed_1333 2 None None None 146303860 Common - haloacid dehalogenase, type II Msed_1088 59 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 146304829 Nonpathogen - hypothetical protein Msed_2081 2 None None None 146303709 Common - class II aldolase/adducin family protein Msed_0929 165 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 146304262 Nonpathogen - hypothetical protein Msed_1497 2 None None None 146302822 Common - transcription elongation factor NusA-like protein Msed_0037 35 COG0195 NusA, Transcription elongation factor Transcription 146303570 Common - protein of unknown function DUF255 Msed_0787 106 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 146303653 Nonpathogen - hypothetical protein Msed_0873 8 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146302966 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Msed_0181 18 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 146304205 Common - putative esterase Msed_1440 18 COG0627 COG0627, Predicted esterase General function prediction only 146304983 Common - AAA family ATPase, CDC48 subfamily Msed_2237 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 146303082 Common - Carbon-monoxide dehydrogenase (acceptor) Msed_0297 113 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 146302918 Nonpathogen - hypothetical protein Msed_0133 2 None None None 146304175 Nonpathogen - hypothetical protein Msed_1409 1 None None None 146304349 Common - methylated-DNA--protein-cysteine methyltransferase Msed_1586 220 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 146303663 Nonpathogen - Urease accessory protein UreH-like protein Msed_0883 2 COG0829 UreH, Urease accessory protein UreH Posttranslational modification, protein turnover, chaperones 146304808 Nonpathogen - protein of unknown function DUF1641 Msed_2060 7 COG2427 COG2427, Uncharacterized conserved protein Function unknown 146303626 Common - Radical SAM domain protein Msed_0844 23 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 146302884 Nonpathogen - Ribonuclease P, Rpp29 Msed_0099 6 COG1588 POP4, RNase P/RNase MRP subunit p29 Translation, ribosomal structure and biogenesis 146303457 Nonpathogen - hypothetical protein Msed_0674 3 None None None 146303782 Common - Inosine/uridine-preferring nucleoside hydrolase Msed_1006 84 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 146304153 Common - Xanthine and CO dehydrogenase maturation factor XdhC/CoxF family-like protein Msed_1387 50 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 146302824 Nonpathogen - hypothetical protein Msed_0039 6 COG1259 COG1259, Uncharacterized conserved protein Function unknown 146303141 Common - Rhodanese domain protein Msed_0356 144 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 146303132 Nonpathogen - hypothetical protein Msed_0347 4 None None None 146302895 Nonpathogen rpl18p 50S ribosomal protein L18P Msed_0110 34 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 146304781 Nonpathogen - hypothetical protein Msed_2033 5 None None None 146304400 Nonpathogen rpl12p 50S ribosomal protein L12P Msed_1637 23 COG2058 RPP1A, Ribosomal protein L12E/L44/L45/RPP1/RPP2 Translation, ribosomal structure and biogenesis 146302994 Nonpathogen ef1B elongation factor 1-beta Msed_0209 32 COG2092 EFB1, Translation elongation factor EF-1beta Translation, ribosomal structure and biogenesis 146303744 Nonpathogen - blue (type 1) copper domain protein Msed_0966 4 COG3794 PetE, Plastocyanin Energy production and conversion 146303485 Nonpathogen - hypothetical protein Msed_0702 2 COG5397 COG5397, Uncharacterized conserved protein Function unknown 146303797 Common - hypothetical protein Msed_1021 24 None None None 146304167 Nonpathogen - hypothetical protein Msed_1401 5 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146303236 Common - natural resistance-associated macrophage protein Msed_0451 100 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 146303814 Common - L-lactate permease Msed_1041 104 COG1620 LldP, L-lactate permease Energy production and conversion 146303333 Nonpathogen - hypothetical protein Msed_0550 2 None None None 146303806 Common - ABC transporter related Msed_1033 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 146304411 Common - protein of unknown function DUF35 Msed_1648 55 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 146303170 Common - enoyl-CoA hydratase Msed_0385 155 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 146302906 Common - hypothetical protein Msed_0121 49 COG1371 COG1371, Uncharacterized conserved protein Function unknown 146304539 Common - 4-hydroxyphenylacetate 3-hydroxylase Msed_1776 50 COG2368 COG2368, Aromatic ring hydroxylase Secondary metabolites biosynthesis, transport, and catabolism 146303358 Common - peptidase M1, membrane alanine aminopeptidase Msed_0575 166 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 146304281 Nonpathogen - hypothetical protein Msed_1516 2 None None None 146303550 Common - ferric uptake regulator, Fur family Msed_0767 109 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 146302920 Common - ParB domain protein nuclease Msed_0135 13 COG1475 Spo0J, Predicted transcriptional regulators Transcription 146303319 Nonpathogen - hypothetical protein Msed_0536 2 None None None 146304774 Common - amidohydrolase Msed_2026 164 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 146303617 Nonpathogen - hypothetical protein Msed_0834 2 None None None 146304805 Nonpathogen - hypothetical protein Msed_2057 9 COG4344 COG4344, Uncharacterized protein conserved in archaea Function unknown 146303602 Nonpathogen - hypothetical protein Msed_0819 2 COG5440 COG5440, Uncharacterized conserved protein Function unknown 146303478 Common - band 7 protein Msed_0695 220 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 146303439 Common - acetyl-CoA acetyltransferase Msed_0656 170 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 146304654 Nonpathogen - hypothetical protein Msed_1906 2 None None None 146304496 Nonpathogen - Zinc finger, TFIIB-type domain protein Msed_1733 34 COG1405 SUA7, Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB Transcription 146303846 Common - Carotene hydroxylase Msed_1074 14 None None None 146304534 Nonpathogen - hypothetical protein Msed_1771 5 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 146303773 Common - Rieske (2Fe-2S) domain protein Msed_0997 20 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 146303059 Common - acyl-CoA dehydrogenase domain protein Msed_0274 156 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 146303903 Nonpathogen - hypothetical protein Msed_1134 3 None None None 146304756 Common - UspA domain protein Msed_2008 172 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 146304025 Nonpathogen - hypothetical protein Msed_1257 3 None None None 146303526 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Msed_0743 247 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 146304762 Nonpathogen - major facilitator superfamily MFS_1 Msed_2014 1 None None None 146303335 Common - FAD linked oxidase domain protein Msed_0552 120 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 146303442 Nonpathogen - protein of unknown function DUF424 Msed_0659 21 COG2412 COG2412, Uncharacterized conserved protein Function unknown 146304091 Common - type II secretion system protein E Msed_1325 228 COG0630 VirB11, Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis Cell motility and secretion / Intracellular trafficking and secretion 146304210 Nonpathogen - hypothetical protein Msed_1445 3 None None None 146303113 Nonpathogen - hypothetical protein Msed_0328 2 None None None 146302879 Common rpl2p 50S ribosomal protein L2P Msed_0094 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 146304591 Nonpathogen - hypothetical protein Msed_1833 1 None None None 146304720 Nonpathogen - hypothetical protein Msed_1972 2 None None None 146303928 Nonpathogen - hypothetical protein Msed_1159 2 None None None 146304009 Common - mercuric reductase Msed_1241 245 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 146304418 Nonpathogen - membrane-bound metal-dependent hydrolase Msed_1655 2 None None None 146303713 Common - hydrogenase expression/formation protein HypE Msed_0933 143 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 146304797 Common - replication factor C large subunit Msed_2049 223 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 146304879 Nonpathogen rpl7ae 50S ribosomal protein L7Ae Msed_2132 41 COG1358 RPL8A, Ribosomal protein HS6-type (S12/L30/L7a) Translation, ribosomal structure and biogenesis 146303676 Nonpathogen - hypothetical protein Msed_0896 10 None None None 146302870 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Msed_0085 84 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 146303391 Common - uroporphyrin-III C-methyltransferase Msed_0608 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 146304120 Common - type III restriction enzyme, res subunit Msed_1354 206 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 146303837 Nonpathogen - protein of unknown function DUF217 Msed_1065 6 None None None 146303885 Common - succinate dehydrogenase or fumarate reductase, flavoprotein subunit Msed_1114 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 146302938 Common - glutaredoxin-like domain protein Msed_0153 35 COG3634 AhpF, Alkyl hydroperoxide reductase, large subunit Posttranslational modification, protein turnover, chaperones 146304275 Nonpathogen - hypothetical protein Msed_1510 2 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 146303463 Nonpathogen - hypothetical protein Msed_0680 13 COG3356 COG3356, Predicted membrane protein Function unknown 146304488 Nonpathogen - helix-turn-helix domain protein Msed_1725 31 COG1395 COG1395, Predicted transcriptional regulator Transcription 146303708 Nonpathogen - hypothetical protein Msed_0928 1 None None None 146304702 Nonpathogen - hypothetical protein Msed_1954 2 None None None 146303875 Nonpathogen - hypothetical protein Msed_1103 2 None None None 146304071 Common - high-affinity nickel-transporter Msed_1305 40 COG3376 HoxN, High-affinity nickel permease Inorganic ion transport and metabolism 146304640 Nonpathogen - hypothetical protein Msed_1892 2 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 146303958 Nonpathogen - hypothetical protein Msed_1189 1 None None None 146303914 Nonpathogen - CRISPR locus-related DNA-binding protein Msed_1145 9 COG1414 IclR, Transcriptional regulator Transcription 146304846 Nonpathogen - hypothetical protein Msed_2098 2 None None None 146304572 Common - UDP-glucose 6-dehydrogenase Msed_1810 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 146303961 Nonpathogen - hypothetical protein Msed_1192 2 COG4547 CobT, Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide:5, 6-dimethylbenzimidazole phosphoribosyltransferase) Coenzyme metabolism 146304440 Nonpathogen - hypothetical protein Msed_1677 2 None None None 146303937 Nonpathogen - hypothetical protein Msed_1168 1 None None None 146302931 Common - hypothetical protein Msed_0146 6 None None None 146303216 Common - Pyruvate, water dikinase Msed_0431 134 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 146303226 Common - ABC-type dipeptide transport system periplasmic component-like protein Msed_0441 7 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 146302989 Nonpathogen - transcription elongation factor NusA-like protein Msed_0204 12 COG0195 NusA, Transcription elongation factor Transcription 146304111 Common - thioesterase-like protein Msed_1345 13 COG0824 FcbC, Predicted thioesterase General function prediction only 146303762 Nonpathogen - hypothetical protein Msed_0985 2 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146304409 Common - hypothetical protein Msed_1646 179 COG3425 PksG, 3-hydroxy-3-methylglutaryl CoA synthase Lipid metabolism 146304335 Nonpathogen - hypothetical protein Msed_1572 1 None None None 146304655 Common - DNA polymerase I Msed_1907 61 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 146304799 Common - PEBP family protein Msed_2051 128 COG1881 COG1881, Phospholipid-binding protein General function prediction only 146303577 Nonpathogen - sec-independent translocation protein mttA/Hcf106 Msed_0794 2 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 146302977 Nonpathogen - hypothetical protein Msed_0192 2 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 146303166 Common - Citryl-CoA lyase Msed_0381 112 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 146304037 Common - amino acid permease-associated region Msed_1269 17 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146303103 Nonpathogen - hypothetical protein Msed_0318 2 None None None 146303851 Common - putative peroxiredoxin Msed_1079 220 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 146303829 Common - LmbE family protein Msed_1056 64 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 146304639 Nonpathogen - hypothetical protein Msed_1891 3 COG2014 COG2014, Uncharacterized conserved protein Function unknown 146304850 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Msed_2102 19 COG2241 CobL, Precorrin-6B methylase 1 Coenzyme metabolism 146304221 Common - AMP-dependent synthetase and ligase Msed_1456 220 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 146302929 Common - phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase Msed_0144 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 146304128 Nonpathogen - hypothetical protein Msed_1362 4 COG5440 COG5440, Uncharacterized conserved protein Function unknown 146303758 Common - Ppx/GppA phosphatase Msed_0981 181 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 146305011 Nonpathogen - Zinc finger, TFIIB-type domain protein Msed_2265 3 COG1405 SUA7, Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB Transcription 146303022 Common - Fructose-bisphosphate aldolase Msed_0237 66 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 146303122 Common - protein of unknown function DUF6, transmembrane Msed_0337 190 COG4346 COG4346, Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase Posttranslational modification, protein turnover, chaperones 146304956 Common - translation initiation factor Sui1 Msed_2210 88 COG0023 SUI1, Translation initiation factor 1 (eIF-1/SUI1) and related proteins Translation, ribosomal structure and biogenesis 146305040 Nonpathogen - putative transcriptional regulator, AsnC family Msed_2295 24 COG1522 Lrp, Transcriptional regulators Transcription 146304301 Nonpathogen - hypothetical protein Msed_1538 1 None None None 146302814 Common - Nucleoside-diphosphate kinase Msed_0029 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 146304739 Common - lysine biosynthesis protein LysX Msed_1991 109 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 146303970 Common - pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit Msed_1201 76 COG1144 COG1144, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit Energy production and conversion 146303179 Common - AMP-dependent synthetase and ligase Msed_0394 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 146304913 Nonpathogen - hypothetical protein Msed_2166 28 COG1992 COG1992, Uncharacterized conserved protein Function unknown 146303844 Common - Alpha/beta hydrolase fold-3 domain protein Msed_1072 143 COG0657 Aes, Esterase/lipase Lipid metabolism 146303157 Common - protein of unknown function DUF395, YeeE/YedE Msed_0372 41 COG2391 COG2391, Predicted transporter component General function prediction only 146303895 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Msed_1125 120 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 146303564 Nonpathogen - Selenophosphate synthase-like protein Msed_0781 6 COG0709 SelD, Selenophosphate synthase Amino acid transport and metabolism 146304182 Nonpathogen - thiamineS protein Msed_1416 4 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 146304732 Common - phosphoribosylaminoimidazole synthetase Msed_1984 235 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 146304380 Common - Fmu (Sun) domain protein Msed_1617 206 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 146304073 Nonpathogen - PilT protein domain protein Msed_1307 7 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 146304453 Common trpA tryptophan synthase subunit alpha Msed_1690 216 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 146303581 Nonpathogen - hypothetical protein Msed_0798 1 None None None 146303972 Nonpathogen - hypothetical protein Msed_1203 1 None None None 146303384 Common - Alcohol dehydrogenase GroES domain protein Msed_0601 197 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 146304136 Nonpathogen - hypothetical protein Msed_1370 1 None None None 146303019 Common - hypothetical protein Msed_0234 17 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146304324 Nonpathogen - hypothetical protein Msed_1561 3 None None None 146303451 Common - ATPase associated with various cellular activities, AAA_5 Msed_0668 41 COG0714 COG0714, MoxR-like ATPases General function prediction only 146303294 Common - Radical SAM domain protein Msed_0511 186 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 146303643 Nonpathogen - hypothetical protein Msed_0862 2 None None None 146304104 Nonpathogen - hypothetical protein Msed_1338 2 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 146304569 Nonpathogen - hypothetical protein Msed_1807 2 COG2373 COG2373, Large extracellular alpha-helical protein General function prediction only 146302797 Common - Prephenate dehydratase Msed_0012 208 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 146303539 Common - protein of unknown function DUF557 Msed_0756 17 COG1892 COG1892, Uncharacterized protein conserved in archaea Function unknown 146304793 Nonpathogen - hypothetical protein Msed_2045 2 COG1818 COG1818, Predicted RNA-binding protein, contains THUMP domain General function prediction only 146303781 Common - regulatory protein, ArsR Msed_1005 121 COG0640 ArsR, Predicted transcriptional regulators Transcription 146304837 Common - Cobaltochelatase Msed_2089 89 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 146303505 Nonpathogen - hypothetical protein Msed_0722 2 None None None 146303706 Common - transcriptional regulator, HxlR family Msed_0926 81 COG1733 COG1733, Predicted transcriptional regulators Transcription 146304376 Common - ABC transporter related Msed_1613 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 146303649 Common - transcriptional regulator, PadR-like family Msed_0868 51 COG1695 COG1695, Predicted transcriptional regulators Transcription 146305018 Common - tRNA-guanine transglycosylase, various specificities Msed_2272 213 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 146303182 Common - protein of unknown function DUF35 Msed_0397 46 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 146304387 Nonpathogen - 30S ribosomal protein S19e Msed_1624 34 COG2238 RPS19A, Ribosomal protein S19E (S16A) Translation, ribosomal structure and biogenesis 146303901 Nonpathogen - hypothetical protein Msed_1131 1 None None None 146304560 Common - protein kinase Msed_1797 38 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 146304668 Nonpathogen - V-type ATP synthase subunit K Msed_1920 2 None None None 146303985 Common - MaoC domain protein dehydratase Msed_1216 63 COG2030 MaoC, Acyl dehydratase Lipid metabolism 146304556 Nonpathogen - DNA primase small subunit Msed_1793 31 COG1467 PRI1, Eukaryotic-type DNA primase, catalytic (small) subunit DNA replication, recombination, and repair 146304673 Common - ATPase (PilT family)-like protein Msed_1925 49 COG1855 COG1855, ATPase (PilT family) General function prediction only 146303041 Common - Glyoxylate reductase Msed_0256 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 146304764 Common - FeoA family protein Msed_2016 92 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 146303640 Common - drug resistance transporter, EmrB/QacA subfamily Msed_0859 218 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146303092 Common - pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit Msed_0307 72 COG1144 COG1144, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit Energy production and conversion 146304605 Common - Nucleotidyl transferase Msed_1857 226 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 146303635 Nonpathogen - Rossmann fold nucleotide-binding protein-like protein Msed_0853 18 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 146303711 Common - hydrogenase assembly chaperone hypC/hupF Msed_0931 80 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 146303007 Common - FAD dependent oxidoreductase Msed_0222 102 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 146304934 Nonpathogen - hypothetical protein Msed_2187 2 None None None 146304906 Nonpathogen - nucleotidyltransferase-like protein Msed_2159 12 COG2413 COG2413, Predicted nucleotidyltransferase General function prediction only 146303996 Nonpathogen - Conserved TM helix repeat-containing protein Msed_1227 3 None None None 146304757 Common - pyridine nucleotide-disulphide oxidoreductase dimerisation region Msed_2009 238 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 146303287 Nonpathogen - hypothetical protein Msed_0504 3 COG3889 COG3889, Predicted solute binding protein General function prediction only 146304449 Common - anthranilate synthase component II Msed_1686 240 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 146303718 Nonpathogen - hypothetical protein Msed_0938 2 None None None 146303400 Common - ABC transporter related Msed_0617 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 146304632 Common - Glutamate synthase (NADPH) Msed_1884 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 146304501 Nonpathogen - Wyosine base formation Msed_1738 33 COG0731 COG0731, Fe-S oxidoreductases Energy production and conversion 146303761 Common - amidohydrolase 2 Msed_0984 25 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 146304359 Common - pyruvate ferredoxin/flavodoxin oxidoreductase Msed_1596 80 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 146303304 Common - ABC transporter related Msed_0521 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 146304901 Common - DNA polymerase II Msed_2154 67 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 146304224 Nonpathogen - putative transcriptional regulator Msed_1459 2 COG2345 COG2345, Predicted transcriptional regulator Transcription 146303347 Nonpathogen - hypothetical protein Msed_0564 29 COG1992 COG1992, Uncharacterized conserved protein Function unknown 146304687 Common - ATP--cobalamin adenosyltransferase Msed_1939 131 COG2096 COG2096, Uncharacterized conserved protein Function unknown 146303699 Common - Radical SAM domain protein Msed_0919 151 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 146304889 Common rps9p 30S ribosomal protein S9P Msed_2142 54 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 146304498 Common - diphthine synthase Msed_1735 36 COG1798 DPH5, Diphthamide biosynthesis methyltransferase Translation, ribosomal structure and biogenesis 146304726 Nonpathogen - hypothetical protein Msed_1978 8 COG1828 PurS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component Nucleotide transport and metabolism 146302970 Common - ribokinase Msed_0185 216 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 146303665 Common - Urease accessory protein UreF Msed_0885 24 COG0830 UreF, Urease accessory protein UreF Posttranslational modification, protein turnover, chaperones 146304352 Common - UspA domain protein Msed_1589 139 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 146304323 Common - biotin/lipoate A/B protein ligase Msed_1560 56 COG0095 LplA, Lipoate-protein ligase A Coenzyme metabolism 146304035 Nonpathogen - hypothetical protein Msed_1267 6 COG3432 COG3432, Predicted transcriptional regulator Transcription 146302964 Common - ABC transporter related Msed_0179 244 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 146304517 Common - DNA topoisomerase VI subunit B Msed_1754 34 COG1389 COG1389, DNA topoisomerase VI, subunit B DNA replication, recombination, and repair 146302953 Common - lysine biosynthesis protein LysX Msed_0168 115 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 146304844 Common ubiA prenyltransferase Msed_2096 158 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 146304253 Nonpathogen - hypothetical protein Msed_1488 8 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 146304471 Nonpathogen - hypothetical protein Msed_1708 6 None None None 146305003 Common - S-adenosyl-L-homocysteine hydrolase Msed_2257 178 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 146303481 Nonpathogen - hypothetical protein Msed_0698 1 None None None 146303193 Common - amino acid permease-associated region Msed_0408 185 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 146304972 Common - non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family Msed_2226 237 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 146304049 Nonpathogen - hypothetical protein Msed_1282 3 COG3473 COG3473, Maleate cis-trans isomerase Secondary metabolites biosynthesis, transport, and catabolism 146304310 Nonpathogen - Heterodisulfide reductase subunit C-like protein Msed_1547 28 COG1150 HdrC, Heterodisulfide reductase, subunit C Energy production and conversion 146303572 Nonpathogen - hypothetical protein Msed_0789 2 None None None 146304117 Common - transcriptional activator, TenA family Msed_1351 77 COG0819 TenA, Putative transcription activator Transcription 146303673 Common - protein of unknown function DUF124 Msed_0893 78 COG2013 COG2013, Uncharacterized conserved protein Function unknown 146303857 Nonpathogen - Dehydrogenase (flavoprotein)-like protein Msed_1085 13 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 146302851 Common - tRNA/rRNA methyltransferase (SpoU) Msed_0066 151 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 146303628 Common - General substrate transporter Msed_0846 87 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 146304166 Common - threonine synthase Msed_1400 116 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 146302869 Common - elongation factor EF-2 Msed_0084 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 146303908 Nonpathogen - hypothetical protein Msed_1139 2 None None None 146304423 Nonpathogen - hypothetical protein Msed_1660 2 None None None 146303596 Common - TPR repeat-containing protein Msed_0813 103 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 146304892 Nonpathogen - RNA polymerase, insert Msed_2145 34 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 146303925 Nonpathogen - protein of unknown function DUF395, YeeE/YedE Msed_1156 22 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 146304816 Nonpathogen - hypothetical protein Msed_2068 2 None None None 146302883 Nonpathogen - 50S ribosomal protein L29 Msed_0098 2 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 146304862 Common - putative signal transduction protein with CBS domains Msed_2115 178 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 146304086 Common - formate dehydrogenase family accessory protein FdhD Msed_1320 137 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 146303512 Common - Xylose isomerase domain protein TIM barrel Msed_0729 34 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 146304425 Common - glycine cleavage system protein H Msed_1662 184 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 146304893 Common rps11p 30S ribosomal protein S11P Msed_2146 214 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 146303247 Common - major facilitator superfamily MFS_1 Msed_0462 144 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 146304643 Nonpathogen - NADH dehydrogenase subunit A Msed_1895 5 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 146304864 Nonpathogen - hypothetical protein Msed_2117 3 None None None 146303887 Common - hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit Msed_1116 144 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 146303669 Common - amino acid permease-associated region Msed_0889 162 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146304922 Nonpathogen - transcriptional regulator, TrmB Msed_2175 3 COG3355 COG3355, Predicted transcriptional regulator Transcription 146304330 Nonpathogen - hypothetical protein Msed_1567 2 None None None 146304997 Nonpathogen - Like-Sm ribonucleoprotein, core Msed_2251 31 COG1958 LSM1, Small nuclear ribonucleoprotein (snRNP) homolog Transcription 146303902 Common - hypothetical protein Msed_1132 3 COG1106 COG1106, Predicted ATPases General function prediction only 146304943 Nonpathogen - hypothetical protein Msed_2196 2 None None None 146303492 Common - aspartate-semialdehyde dehydrogenase Msed_0709 208 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 146302843 Common - methyltransferase small Msed_0058 124 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 146304407 Nonpathogen - hypothetical protein Msed_1644 2 None None None 146302807 Nonpathogen - hypothetical protein Msed_0022 2 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 146303631 Nonpathogen - hypothetical protein Msed_0849 2 None None None 146303775 Nonpathogen - DNA polymerase, beta domain protein region Msed_0999 6 None None None 146303749 Common - major facilitator superfamily MFS_1 Msed_0972 29 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146303033 Nonpathogen - hypothetical protein Msed_0248 2 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146303821 Common - binding-protein-dependent transport systems inner membrane component Msed_1048 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 146303540 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Msed_0757 231 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 146303654 Common - Arginine deiminase Msed_0874 57 COG2235 ArcA, Arginine deiminase Amino acid transport and metabolism 146304575 Nonpathogen - hypothetical protein Msed_1813 2 None None None 146303853 Common - sodium/hydrogen exchanger Msed_1081 88 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 146303399 Nonpathogen - hypothetical protein Msed_0616 7 None None None 146304173 Nonpathogen - hypothetical protein Msed_1407 1 None None None 146303275 Common - heavy metal translocating P-type ATPase Msed_0490 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 146305037 Nonpathogen - preprotein translocase subunit SecG Msed_2292 2 COG4023 SBH1, Preprotein translocase subunit Sec61beta Intracellular trafficking and secretion 146304069 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Msed_1303 124 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 146303102 Nonpathogen - hypothetical protein Msed_0317 2 None None None 146303935 Nonpathogen - protein of unknown function DUF324 Msed_1166 2 None None None 146303612 Common leuD 3-isopropylmalate dehydratase small subunit Msed_0829 138 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 146304378 Common - AMP-dependent synthetase and ligase Msed_1615 217 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 146304856 Nonpathogen - hypothetical protein Msed_2109 4 None None None 146303301 Nonpathogen - hypothetical protein Msed_0518 3 None None None 146304103 Common - ATPase involved in chromosome partitioning-like protein Msed_1337 7 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146304126 Common - hypothetical protein Msed_1360 26 COG2324 COG2324, Predicted membrane protein Function unknown 146303698 Common - hypothetical protein Msed_0918 13 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 146304084 Common - formate dehydrogenase, alpha subunit Msed_1318 216 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 146303589 Common - transport system permease protein Msed_0806 184 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 146302908 Nonpathogen - hypothetical protein Msed_0123 1 None None None 146304494 Common - Uncharacterized coiled-coil protein-like protein Msed_1731 39 COG1340 COG1340, Uncharacterized archaeal coiled-coil protein Function unknown 146304531 Common - hypothetical protein Msed_1768 11 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 146303229 Common - binding-protein-dependent transport systems inner membrane component Msed_0444 216 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 146304541 Common - short-chain dehydrogenase/reductase SDR Msed_1778 238 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 146303521 Nonpathogen - hypothetical protein Msed_0738 2 None None None 146305022 Nonpathogen - helix-turn-helix domain protein Msed_2276 33 COG1813 COG1813, Predicted transcription factor, homolog of eukaryotic MBF1 Transcription 146304599 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Msed_1851 166 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 146303548 Nonpathogen - hypothetical protein Msed_0765 2 None None None 146304017 Common - FAD dependent oxidoreductase Msed_1249 53 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 146304002 Common - ABC transporter related Msed_1233 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 146304156 Common - ATPase, BadF/BadG/BcrA/BcrD type Msed_1390 48 COG2971 COG2971, Predicted N-acetylglucosamine kinase Carbohydrate transport and metabolism 146304831 Nonpathogen - hypothetical protein Msed_2083 2 None None None 146303476 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Msed_0693 140 COG2243 CobF, Precorrin-2 methylase Coenzyme metabolism 146303448 Nonpathogen - hypothetical protein Msed_0665 2 None None None 146304708 Common - dihydroorotate dehydrogenase family protein Msed_1960 208 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 146303619 Nonpathogen - hypothetical protein Msed_0836 2 None None None 146303268 Nonpathogen - hypothetical protein Msed_0483 2 None None None 146304135 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Msed_1369 27 COG4934 COG4934, Predicted protease Posttranslational modification, protein turnover, chaperones 146304093 Nonpathogen - hypothetical protein Msed_1327 2 None None None 146303057 Common - acyl-CoA dehydrogenase domain protein Msed_0272 154 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 146304272 Common - Radical SAM domain protein Msed_1507 15 COG1856 COG1856, Uncharacterized homolog of biotin synthetase Function unknown 146304288 Common - metallophosphoesterase Msed_1524 21 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 146304772 Common - Molybdopterin-guanine dinucleotide biosynthesis protein A-like protein Msed_2024 17 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 146303766 Nonpathogen - protein of unknown function DUF973 Msed_0990 2 None None None 146303264 Nonpathogen - hypothetical protein Msed_0479 1 None None None 146304027 Nonpathogen - hypothetical protein Msed_1259 2 None None None 146303528 Nonpathogen - protein of unknown function DUF371 Msed_0745 26 COG2090 COG2090, Uncharacterized protein conserved in archaea Function unknown 146304011 Common - Radical SAM domain protein Msed_1243 121 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 146303719 Common - conserved protein containing a thioredoxin domain-like protein Msed_0939 41 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 146304824 Common - NUDIX hydrolase Msed_2076 163 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 146304520 Common - GTP-binding signal recognition particle SRP54, G- domain Msed_1757 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 146304525 Nonpathogen - hypothetical protein Msed_1762 5 None None None 146304200 Nonpathogen - hypothetical protein Msed_1435 1 None None None 146304681 Common - (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase Msed_1933 64 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 146304207 Nonpathogen - Methyltransferase type 11 Msed_1442 21 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 146303061 Common - acyl-CoA dehydrogenase domain protein Msed_0276 164 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 146303926 Nonpathogen - hypothetical protein Msed_1157 1 None None None 146303568 Nonpathogen - hypothetical protein Msed_0785 2 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 146304047 Common - major facilitator superfamily MFS_1 Msed_1280 178 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146303184 Common - 3-hydroxyacyl-CoA dehydrogenase, NAD-binding Msed_0399 188 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 146304442 Nonpathogen - hypothetical protein Msed_1679 2 None None None 146303984 Nonpathogen - hypothetical protein Msed_1215 4 None None None 146303085 Common - peptidase M1, membrane alanine aminopeptidase Msed_0300 175 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 146304795 Nonpathogen - hypothetical protein Msed_2047 3 None None None 146303421 Common - methylmalonyl-CoA mutase, large subunit Msed_0638 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 146304145 Nonpathogen - hypothetical protein Msed_1379 9 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 146303220 Common - hypothetical protein Msed_0435 21 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 146303685 Common - Alcohol dehydrogenase GroES domain protein Msed_0905 204 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 146303723 Nonpathogen - hypothetical protein Msed_0943 3 None None None 146303213 Common - NADPH-dependent FMN reductase Msed_0428 103 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 146303134 Nonpathogen - hypothetical protein Msed_0349 10 None None None 146304315 Nonpathogen - hypothetical protein Msed_1552 2 None None None 146304838 Nonpathogen - Peptidase A24B, FlaK-like protein Msed_2090 5 None None None 146303146 Common - amino acid permease-associated region Msed_0361 115 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146302980 Nonpathogen - peptidase M48, Ste24p Msed_0195 9 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 146304338 Common - GHMP kinase Msed_1575 17 COG3890 ERG8, Phosphomevalonate kinase Lipid metabolism 146304219 Common - beta-lactamase domain protein Msed_1454 79 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 146302821 Nonpathogen - 50S ribosomal protein L30e Msed_0036 22 COG1911 RPL30, Ribosomal protein L30E Translation, ribosomal structure and biogenesis 146303143 Common - glycosyl transferase, family 2 Msed_0358 28 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 146302936 Common dcd deoxycytidine triphosphate deaminase Msed_0151 150 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 146303292 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Msed_0509 130 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 146303816 Nonpathogen - hypothetical protein Msed_1043 3 COG4345 COG4345, Uncharacterized protein conserved in archaea Function unknown 146304503 Common gatC aspartyl/glutamyl-tRNA amidotransferase subunit C Msed_1740 87 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 146302897 Nonpathogen rpl30p 50S ribosomal protein L30P Msed_0112 34 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 146303469 Nonpathogen - hypothetical protein Msed_0686 2 None None None 146303263 Nonpathogen - hypothetical protein Msed_0478 2 None None None 146304337 Nonpathogen - hypothetical protein Msed_1574 2 None None None 146303331 Common - protein of unknown function DUF1634 Msed_0548 16 COG4272 COG4272, Predicted membrane protein Function unknown 146304821 Common - ATPase-like protein Msed_2073 15 COG1106 COG1106, Predicted ATPases General function prediction only 146303425 Common - elongation factor Tu, domain 2 protein Msed_0642 240 COG5258 GTPBP1, GTPase General function prediction only 146304267 Nonpathogen - protein of unknown function DUF1404 Msed_1502 2 None None None 146302969 Common - phosphomethylpyrimidine kinase Msed_0184 222 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 146303109 Common - Cytochrome-c oxidase Msed_0324 169 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 146303070 Nonpathogen - hypothetical protein Msed_0285 2 None None None 146304570 Common - glycosyl transferase, group 1 Msed_1808 83 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 146304803 Common - cobalamin B12-binding domain protein Msed_2055 111 COG2185 Sbm, Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) Lipid metabolism 146303258 Nonpathogen - hypothetical protein Msed_0473 2 None None None 146304197 Common - Formate hydrogenlyase subunit 4-like protein Msed_1432 75 COG0650 HyfC, Formate hydrogenlyase subunit 4 Energy production and conversion 146303016 Common - S-adenosylmethionine synthetase Msed_0231 43 COG1812 MetK, Archaeal S-adenosylmethionine synthetase Amino acid transport and metabolism 146303079 Common - hypothetical protein Msed_0294 14 None None None 146303787 Common - undecaprenyl pyrophosphate phosphatase Msed_1011 186 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 146303029 Nonpathogen - hypothetical protein Msed_0244 2 None None None 146304644 Common - NADH dehydrogenase subunit C Msed_1896 173 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 146304399 Common rplP0 acidic ribosomal protein P0 Msed_1636 58 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 146303499 Common - NAD+ synthetase Msed_0716 216 COG0171 NadE, NAD synthase Coenzyme metabolism 146304784 Common - dTMP kinase Msed_2036 199 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 146304658 Nonpathogen - hypothetical protein Msed_1910 6 None None None 146302960 Nonpathogen - hypothetical protein Msed_0175 1 None None None 146304613 Nonpathogen rpl10e 50S ribosomal protein L10e Msed_1865 34 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 146303177 Nonpathogen - Rieske (2Fe-2S) domain protein Msed_0392 11 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 146304007 Nonpathogen - protein of unknown function DUF981 Msed_1238 7 COG3374 COG3374, Predicted membrane protein Function unknown 146304130 Common - GMP synthase subunit A Msed_1364 240 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 146303670 Common - beta-lactamase domain protein Msed_0890 77 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 146304552 Common - putative RNA methylase Msed_1789 36 COG1041 COG1041, Predicted DNA modification methylase DNA replication, recombination, and repair 146303893 Common - SAF domain protein Msed_1123 66 COG2721 UxaA, Altronate dehydratase Carbohydrate transport and metabolism 146304260 Nonpathogen - hypothetical protein Msed_1495 3 None None None 146304810 Nonpathogen - hypothetical protein Msed_2062 1 None None None 146304231 Common - protein of unknown function DUF162 Msed_1466 95 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 146302872 Nonpathogen - protein of unknown function DUF447 Msed_0087 3 COG2457 COG2457, Uncharacterized conserved protein Function unknown 146304768 Common - Methyltransferase type 11 Msed_2020 113 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 146303794 Common - Thermopsin Msed_1018 40 COG4953 PbpC, Membrane carboxypeptidase/penicillin-binding protein PbpC Cell envelope biogenesis, outer membrane 146303828 Common - major facilitator superfamily MFS_1 Msed_1055 128 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 146304277 Common - General substrate transporter Msed_1512 153 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146304303 Common - sodium/calcium exchanger membrane region Msed_1540 4 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 146303068 Nonpathogen - hypothetical protein Msed_0283 2 None None None 146303912 Nonpathogen - CRISPR-associated autoregulator, DevR family Msed_1143 13 COG1857 COG1857, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 146302937 Nonpathogen - hypothetical protein Msed_0152 6 None None None 146302839 Common - DEAD/DEAH box helicase domain protein Msed_0054 240 COG1201 Lhr, Lhr-like helicases General function prediction only 146304341 Common - purine or other phosphorylase, family 1 Msed_1578 96 COG2820 Udp, Uridine phosphorylase Nucleotide transport and metabolism 146302885 Nonpathogen rps17p 30S ribosomal protein S17P Msed_0100 34 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 146302987 Nonpathogen - nucleotidyltransferase-like protein Msed_0202 8 COG4914 COG4914, Predicted nucleotidyltransferase General function prediction only 146303979 Common - Rhodanese domain protein Msed_1210 145 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 146304244 Common - putative signal-transduction protein with CBS domains Msed_1479 154 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 146302930 Common - ribosomal-protein-alanine acetyltransferase Msed_0145 167 COG0456 RimI, Acetyltransferases General function prediction only 146304573 Common - putative UTP-glucose-1-phosphate uridylyltransferase GalU Msed_1811 223 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 146303832 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Msed_1059 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 146304421 Common - FeS assembly ATPase SufC Msed_1658 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 146303510 Common - FAD linked oxidase domain protein Msed_0727 162 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 146304362 Nonpathogen nac nascent polypeptide-associated complex protein Msed_1599 32 COG1308 EGD2, Transcription factor homologous to NACalpha-BTF3 Transcription 146303792 Common - ATPase (AAA+ superfamily)-like protein Msed_1016 64 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 146303375 Nonpathogen - S-layer domain-like protein Msed_0592 15 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 146302861 Nonpathogen - exosome complex RNA-binding protein Rrp4 Msed_0076 24 COG1097 RRP4, RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain) Translation, ribosomal structure and biogenesis 146304114 Nonpathogen - HEPN domain protein Msed_1348 9 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 146302967 Nonpathogen - hypothetical protein Msed_0182 2 None None None 146303720 Nonpathogen - hypothetical protein Msed_0940 1 None None None 146303563 Common - Rhodanese domain protein Msed_0780 45 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 146304070 Common - LmbE family protein Msed_1304 70 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 146304413 Common glyA serine hydroxymethyltransferase Msed_1650 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 146303977 Nonpathogen - hypothetical protein Msed_1208 1 None None None 146303818 Common - HEPN domain protein Msed_1045 24 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 146304189 Common - 3-hydroxybutyryl-CoA dehydrogenase Msed_1423 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 146304696 Common - phosphoribosyl-ATP pyrophosphohydrolase Msed_1948 100 COG0140 HisI, Phosphoribosyl-ATP pyrophosphohydrolase Amino acid transport and metabolism 146303849 Nonpathogen - hypothetical protein Msed_1077 2 None None None 146304554 Nonpathogen - protein of unknown function, ATP binding Msed_1791 15 COG1100 COG1100, GTPase SAR1 and related small G proteins General function prediction only 146303241 Nonpathogen - hypothetical protein Msed_0456 12 COG1599 RFA1, Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins DNA replication, recombination, and repair 146304389 Nonpathogen rpl39e 50S ribosomal protein L39e Msed_1626 30 COG2167 RPL39, Ribosomal protein L39E Translation, ribosomal structure and biogenesis 146304252 Common - PP-loop domain protein Msed_1487 162 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 146304937 Common - AAA ATPase Msed_2190 15 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 146304967 Common - putative thiazole biosynthetic enzyme Msed_2221 36 COG1635 THI4, Flavoprotein involved in thiazole biosynthesis Coenzyme metabolism 146303947 Common - Glycerophosphodiester phosphodiesterase Msed_1178 179 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 146303346 Nonpathogen - hypothetical protein Msed_0563 1 None None None 146304753 Common - putative transcriptional regulator, CopG family Msed_2005 42 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 146303637 Nonpathogen - Bacterio-opsin activator, HTH domain protein Msed_0856 10 COG3413 COG3413, Predicted DNA binding protein General function prediction only 146304883 Common - isopentenyl pyrophosphate isomerase Msed_2136 84 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 146304438 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Msed_1675 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 146302832 Nonpathogen - riboflavin synthase Msed_0047 22 COG1731 COG1731, Archaeal riboflavin synthase Coenzyme metabolism 146304675 Common - ketol-acid reductoisomerase Msed_1927 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 146304724 Common - methionyl-tRNA synthetase, beta subunit Msed_1976 182 COG0073 ARC1, EMAP domain General function prediction only 146304566 Nonpathogen rpl44e 50S ribosomal protein L44e Msed_1804 33 COG1631 RPL42A, Ribosomal protein L44E Translation, ribosomal structure and biogenesis 146304895 Common rps13p 30S ribosomal protein S13P Msed_2148 51 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 146303435 Nonpathogen - hypothetical protein Msed_0652 2 None None None 146304259 Common - DEAD/DEAH box helicase domain protein Msed_1494 237 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 146303503 Common - Uracil-DNA glycosylase superfamily Msed_0720 102 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 146303371 Common - amino acid permease-associated region Msed_0588 66 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146302944 Nonpathogen - hypothetical protein Msed_0159 6 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 146303675 Nonpathogen - Cupin 2, conserved barrel domain protein Msed_0895 16 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 146304299 Nonpathogen - transcriptional regulator, AbrB family Msed_1535 4 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 146303325 Nonpathogen - hypothetical protein Msed_0542 1 None None None 146302856 Nonpathogen - protein of unknown function DUF54 Msed_0071 17 COG1325 COG1325, Predicted exosome subunit Translation, ribosomal structure and biogenesis 146304518 Common - DNA topoisomerase VI subunit A Msed_1755 34 COG1697 COG1697, DNA topoisomerase VI, subunit A DNA replication, recombination, and repair 146304602 Nonpathogen - hypothetical protein Msed_1854 1 None None None 146303124 Nonpathogen - hypothetical protein Msed_0339 6 None None None 146303940 Common - CRISPR-associated HD domain protein Msed_1171 42 COG1203 COG1203, Predicted helicases General function prediction only 146303366 Common - type III restriction enzyme, res subunit Msed_0583 118 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 146304382 Common - phage integrase family protein Msed_1619 219 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 146303467 Nonpathogen - hypothetical protein Msed_0684 2 COG0622 COG0622, Predicted phosphoesterase General function prediction only 146303599 Nonpathogen - hypothetical protein Msed_0816 4 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 146302959 Common - NAD-dependent epimerase/dehydratase Msed_0174 232 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 146304638 Common - Nucleotidyl transferase Msed_1890 237 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 146303949 Common - ABC transporter related Msed_1180 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 146304460 Common - UbiD family decarboxylase Msed_1697 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 146303994 Nonpathogen - hypothetical protein Msed_1225 2 None None None 146304433 Nonpathogen - hypothetical protein Msed_1670 7 None None None 146304472 Nonpathogen - hypothetical protein Msed_1709 2 None None None 146303066 Common - methylcitrate synthase Msed_0281 192 COG0372 GltA, Citrate synthase Energy production and conversion 146304979 Common - transcriptional regulator, TrmB Msed_2233 20 COG1378 COG1378, Predicted transcriptional regulators Transcription 146304479 Common - ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent Msed_1716 222 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 146304030 Nonpathogen - hypothetical protein Msed_1262 2 None None None 146304960 Nonpathogen - hypothetical protein Msed_2214 5 None None None 146303584 Nonpathogen - hypothetical protein Msed_0801 2 None None None 146303306 Nonpathogen - hypothetical protein Msed_0523 2 None None None 146302952 Nonpathogen - hypothetical protein Msed_0167 8 None None None 146304063 Common - PfkB domain protein Msed_1297 171 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 146303969 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Msed_1200 115 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 146303868 Common - NAD-dependent deacetylase Msed_1096 152 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 146303594 Nonpathogen - hypothetical protein Msed_0811 2 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 146303735 Common - ATPase involved in chromosome partitioning-like protein Msed_0956 9 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146304970 Common - O-sialoglycoprotein endopeptidase Msed_2224 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 146304584 Common - protein of unknown function DUF1177 Msed_1822 14 None None None 146303009 Nonpathogen - protein of unknown function DUF343 Msed_0224 11 COG2835 COG2835, Uncharacterized conserved protein Function unknown 146302802 Nonpathogen purP 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase Msed_0017 20 COG1759 COG1759, ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases) General function prediction only 146303239 Nonpathogen - hypothetical protein Msed_0454 4 None None None 146302794 Common radA DNA repair and recombination protein RadA Msed_0009 245 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 146304742 Common - Cupin 2, conserved barrel domain protein Msed_1994 34 COG3435 COG3435, Gentisate 1,2-dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 146302841 Nonpathogen - DKCLD domain protein Msed_0056 33 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 146303957 Nonpathogen - hypothetical protein Msed_1188 2 None None None 146303553 Nonpathogen - hypothetical protein Msed_0770 2 None None None 146304670 Nonpathogen - 30S ribosomal protein S26e Msed_1922 10 COG4830 RPS26B, Ribosomal protein S26 Translation, ribosomal structure and biogenesis 146304718 Nonpathogen - regulatory protein, ArsR Msed_1970 10 COG4189 COG4189, Predicted transcriptional regulator Transcription 146304669 Common - prolyl-tRNA synthetase Msed_1921 249 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146304304 Common - protein of unknown function DUF202 Msed_1541 18 COG2149 COG2149, Predicted membrane protein Function unknown 146303688 Nonpathogen - PilT protein domain protein Msed_0908 7 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 146304777 Common - TatD-related deoxyribonuclease Msed_2029 235 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 146303083 Common - (2Fe-2S)-binding domain protein Msed_0298 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 146303261 Nonpathogen - hypothetical protein Msed_0476 2 None None None 146305012 Nonpathogen - tRNA-splicing endonuclease subunit beta Msed_2266 7 COG1676 SEN2, tRNA splicing endonuclease Translation, ribosomal structure and biogenesis 146303164 Nonpathogen - SirA family protein Msed_0379 4 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 146304749 Common - Enoyl-CoA hydratase/isomerase Msed_2001 180 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 146305021 Common - proteasome-activating nucleotidase Msed_2275 249 COG1222 RPT1, ATP-dependent 26S proteasome regulatory subunit Posttranslational modification, protein turnover, chaperones 146303158 Common - SirA family protein Msed_0373 23 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 146303114 Common - protein kinase Msed_0329 36 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 146303176 Common - Amino acid transporter-like protein Msed_0391 10 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146303874 Common - hypothetical protein Msed_1102 6 COG1106 COG1106, Predicted ATPases General function prediction only 146303470 Nonpathogen - FAD dependent oxidoreductase Msed_0687 19 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 146303519 Nonpathogen - hypothetical protein Msed_0736 2 None None None 146303763 Nonpathogen - TENA/THI-4 domain protein Msed_0987 4 COG5424 COG5424, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C Coenzyme metabolism 146304039 Common - hypothetical protein Msed_1271 17 COG1275 TehA, Tellurite resistance protein and related permeases Inorganic ion transport and metabolism 146304616 Nonpathogen - hypothetical protein Msed_1868 2 None None None 146303310 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Msed_0527 106 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 146302975 Common - putative transcriptional regulator, GntR family Msed_0190 210 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 146303743 Nonpathogen - hypothetical protein Msed_0965 2 None None None 146303697 Common - hydrogenase expression/formation protein (HUPF/HYPC) Msed_0917 22 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 146304712 Common pyrB aspartate carbamoyltransferase catalytic subunit Msed_1964 235 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 146304078 Common - amino acid permease-associated region Msed_1312 158 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146303098 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Msed_0313 19 COG4934 COG4934, Predicted protease Posttranslational modification, protein turnover, chaperones 146304990 Nonpathogen - 30S ribosomal protein S6e Msed_2244 34 COG2125 RPS6A, Ribosomal protein S6E (S10) Translation, ribosomal structure and biogenesis 146304119 Common - acetyl-CoA synthetase Msed_1353 214 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 146304053 Common - ABC transporter related Msed_1286 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 146303807 Common - cobalt transport protein Msed_1034 16 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 146305039 Nonpathogen - hypothetical protein Msed_2294 25 COG2042 COG2042, Uncharacterized conserved protein Function unknown 146303013 Common - CTP synthetase Msed_0228 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 146303389 Nonpathogen - hypothetical protein Msed_0606 2 None None None 146303579 Nonpathogen - hypothetical protein Msed_0796 1 None None None 146303479 Nonpathogen - Peptidase A5, thermopsin Msed_0696 4 None None None 146304984 Common - cofactor-independent phosphoglycerate mutase Msed_2238 51 COG3635 COG3635, Predicted phosphoglycerate mutase, AP superfamily Carbohydrate transport and metabolism 146304628 Common - UBA/THIF-type NAD/FAD binding protein Msed_1880 223 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 146303024 Common - putative signal transduction protein with CBS domains Msed_0239 208 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 146304321 Common - Radical SAM domain protein Msed_1558 21 COG2516 COG2516, Biotin synthase-related enzyme General function prediction only 146304226 Nonpathogen - hypothetical protein Msed_1461 2 COG3889 COG3889, Predicted solute binding protein General function prediction only 146303862 Nonpathogen - hypothetical protein Msed_1090 3 None None None 146303205 Common - major facilitator superfamily MFS_1 Msed_0420 8 None None None 146305030 Nonpathogen - hypothetical protein Msed_2284 2 None None None 146304706 Nonpathogen - hypothetical protein Msed_1958 3 None None None 146304842 Nonpathogen - hypothetical protein Msed_2094 2 None None None 146304492 Nonpathogen - hypothetical protein Msed_1729 5 None None None 146303405 Common - Zn-dependent hydrolase of the beta-lactamase fold-like protein Msed_0622 23 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 146303523 Common - NAD(+) kinase Msed_0740 202 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 146304095 Nonpathogen - hypothetical protein Msed_1329 2 None None None 146303315 Common - putative signal-transduction protein with CBS domains Msed_0532 98 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 146304158 Nonpathogen - hypothetical protein Msed_1392 1 None None None 146304465 Nonpathogen - protein of unknown function DUF650, N-terminal domain Msed_1702 32 COG1602 COG1602, Uncharacterized conserved protein Function unknown 146303535 Common - Small-conductance mechanosensitive channel-like protein Msed_0752 82 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 146303225 Common - peptidase S9, prolyl oligopeptidase active site domain protein Msed_0440 106 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 146303474 Common - Polyprenyl synthetase Msed_0691 237 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 146303446 Nonpathogen - hypothetical protein Msed_0663 2 None None None 146303201 Common - major facilitator superfamily MFS_1 Msed_0416 54 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146303509 Common - histidine triad (HIT) protein Msed_0726 211 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 146304770 Common - molybdopterin-guanine dinucleotide biosynthesis protein B Msed_2022 76 COG1763 MobB, Molybdopterin-guanine dinucleotide biosynthesis protein Coenzyme metabolism 146303660 Common - nitrite and sulphite reductase 4Fe-4S region Msed_0880 129 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 146303428 Common - MoaD family protein Msed_0645 111 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 146304752 Common - B3/4 domain protein Msed_2004 40 COG3382 COG3382, Uncharacterized conserved protein Function unknown 146303917 Nonpathogen - hypothetical protein Msed_1148 1 None None None 146304209 Nonpathogen - DNA polymerase B region Msed_1444 30 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 146304738 Common carB carbamoyl phosphate synthase large subunit Msed_1990 237 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 146303910 Common - CRISPR-associated helicase Cas3 Msed_1141 94 COG1203 COG1203, Predicted helicases General function prediction only 146303717 Nonpathogen - hypothetical protein Msed_0937 1 None None None 146305024 Nonpathogen - protein of unknown function DUF127 Msed_2278 31 COG1303 COG1303, Uncharacterized protein conserved in archaea Function unknown 146304076 Common - cyclase family protein Msed_1310 114 COG1878 COG1878, Predicted metal-dependent hydrolase General function prediction only 146302875 Nonpathogen - hypothetical protein Msed_0090 15 COG2106 COG2106, Uncharacterized conserved protein Function unknown 146303266 Nonpathogen - hypothetical protein Msed_0481 2 None None None 146304355 Nonpathogen - hypothetical protein Msed_1592 2 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146304186 Common - glycoside hydrolase 15-related Msed_1420 67 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 146303002 Common - porphobilinogen deaminase Msed_0217 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 146302901 Nonpathogen - hypothetical protein Msed_0116 2 None None None 146303531 Nonpathogen - hypothetical protein Msed_0748 3 None None None 146303747 Nonpathogen - holliday junction resolvase Msed_0969 13 COG1591 COG1591, Holliday junction resolvase - archaeal type DNA replication, recombination, and repair 146304405 Nonpathogen - hypothetical protein Msed_1642 2 None None None 146303730 Common - hypothetical protein Msed_0950 26 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146303063 Common - 2-methylcitrate dehydratase Msed_0278 88 COG2079 PrpD, Uncharacterized protein involved in propionate catabolism General function prediction only 146304999 Common - Spermine synthase Msed_2253 121 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 146304538 Common - 3,4-dihydroxyphenylacetate 2,3-dioxygenase Msed_1775 48 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 146304766 Nonpathogen - hypothetical protein Msed_2018 2 None None None 146304444 Nonpathogen - hypothetical protein Msed_1681 5 None None None 146304595 Common - glycosyl transferase, group 1 Msed_1844 211 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 146303338 Nonpathogen - hypothetical protein Msed_0555 2 None None None 146303222 Common - major facilitator superfamily MFS_1 Msed_0437 38 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 146304866 Nonpathogen - Alcohol dehydrogenase GroES domain protein Msed_2119 3 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 146302848 Nonpathogen - protein of unknown function DUF655 Msed_0063 33 COG1491 COG1491, Predicted RNA-binding protein Translation, ribosomal structure and biogenesis 146303855 Nonpathogen - hypothetical protein Msed_1083 16 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 146304594 Common - glycosyl transferase, family 2 Msed_1843 8 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 146302819 Common - DNA-directed RNA polymerase subunit alpha Msed_0034 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 146303397 Nonpathogen - protein of unknown function DUF137 Msed_0614 30 COG1701 COG1701, Uncharacterized protein conserved in archaea Function unknown 146304241 Nonpathogen - hypothetical protein Msed_1476 2 None None None 146303208 Common - Anaerobic dehydrogenase typically selenocysteine-containing-like protein Msed_0423 111 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 146304346 Common - HhH-GPD family protein Msed_1583 68 COG2231 COG2231, Uncharacterized protein related to Endonuclease III DNA replication, recombination, and repair 146304115 Nonpathogen - hypothetical protein Msed_1349 4 None None None 146304082 Nonpathogen - hypothetical protein Msed_1316 2 None None None 146304058 Common - AMP-dependent synthetase and ligase Msed_1291 219 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 146304945 Nonpathogen - hypothetical protein Msed_2198 1 None None None 146303610 Nonpathogen - hypothetical protein Msed_0827 2 None None None 146304124 Common - 5-carboxymethyl-2-hydroxymuconate Delta-isomerase Msed_1358 173 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 146304105 Nonpathogen - hypothetical protein Msed_1339 2 None None None 146304740 Nonpathogen - Translin Msed_1992 24 COG2178 COG2178, Predicted RNA-binding protein of the translin family Translation, ribosomal structure and biogenesis 146302817 Nonpathogen rpoH DNA-directed RNA polymerase subunit H Msed_0032 33 COG2012 RPB5, DNA-directed RNA polymerase, subunit H, RpoH/RPB5 Transcription 146304714 Common - orotidine 5'-phosphate decarboxylase Msed_1966 51 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 146303921 Nonpathogen - hypothetical protein Msed_1152 3 COG5551 COG5551, Uncharacterized conserved protein Function unknown 146304981 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Msed_2235 59 COG0388 COG0388, Predicted amidohydrolase General function prediction only 146304812 Common - sodium/hydrogen exchanger Msed_2064 93 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 146304217 Common - phosphoenolpyruvate carboxykinase Msed_1452 59 COG1274 PckA, Phosphoenolpyruvate carboxykinase (GTP) Energy production and conversion 146303555 Common - metallophosphoesterase Msed_0772 30 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 146304826 Nonpathogen - bifunctional phosphoglucose/phosphomannose isomerase Msed_2078 16 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 146302914 Common - glycosyl transferase, group 1 Msed_0129 76 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 146304914 Common - drug exporter of the RND superfamily-like protein Msed_2167 41 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 146304195 Common - NADH ubiquinone oxidoreductase, 20 kDa subunit Msed_1430 192 COG3260 COG3260, Ni,Fe-hydrogenase III small subunit Energy production and conversion 146303053 Common - protein of unknown function DUF35 Msed_0268 13 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 146304367 Common - Nucleotidyl transferase Msed_1604 209 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 146303771 Common - 3,4-dihydroxyphenylacetate 2,3-dioxygenase Msed_0995 40 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 146304064 Common - aldehyde dehydrogenase Msed_1298 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 146303950 Nonpathogen - extracellular solute-binding protein, family 1 Msed_1181 11 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 146302925 Nonpathogen - hypothetical protein Msed_0140 2 None None None 146304239 Common - putative signal transduction protein with CBS domains Msed_1474 184 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 146303037 Common - daunorubicin resistance ABC transporter ATPase subunit Msed_0252 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 146304916 Nonpathogen - peptidase M50 Msed_2169 26 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 146302973 Common - transposase, IS605 OrfB Msed_0188 18 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 146304927 Nonpathogen - hypothetical protein Msed_2180 1 None None None 146303679 Nonpathogen - PilT protein domain protein Msed_0899 5 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 146303667 Common ureC urease subunit alpha Msed_0887 97 COG0804 UreC, Urea amidohydrolase (urease) alpha subunit Amino acid transport and metabolism 146304358 Nonpathogen - hypothetical protein Msed_1595 2 None None None 146303542 Common - hypothetical protein Msed_0759 6 None None None 146303414 Common - dihydropteroate synthase-related protein Msed_0631 31 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 146304332 Nonpathogen - hypothetical protein Msed_1569 2 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 146302810 Common - cytidine deaminase Msed_0025 112 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 146304170 Nonpathogen - hypothetical protein Msed_1404 2 None None None 146304013 Nonpathogen - PilT protein domain protein Msed_1245 6 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 146303010 Nonpathogen - hypothetical protein Msed_0225 8 COG4755 COG4755, Uncharacterized protein conserved in archaea Function unknown 146303369 Common - hypothetical protein Msed_0586 25 COG4754 COG4754, Uncharacterized conserved protein Function unknown 146304485 Nonpathogen - Pre-mRNA processing ribonucleoprotein, binding region Msed_1722 34 COG1498 SIK1, Protein implicated in ribosomal biogenesis, Nop56p homolog Translation, ribosomal structure and biogenesis 146303277 Nonpathogen - putative transcriptional regulator, AsnC family Msed_0492 8 COG1522 Lrp, Transcriptional regulators Transcription 146303823 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Msed_1050 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 146304833 Nonpathogen - major facilitator superfamily MFS_1 Msed_2085 2 None None None 146303100 Common - protein of unknown function DUF6, transmembrane Msed_0315 36 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 146304986 Nonpathogen - DNA-directed RNA polymerase subunit E, RpoE2 Msed_2240 22 COG2093 COG2093, DNA-directed RNA polymerase, subunit E'' Transcription 146303107 Common - Rieske (2Fe-2S) domain protein Msed_0322 15 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 146304032 Common - Ferritin, Dps family protein Msed_1264 22 COG2406 COG2406, Protein distantly related to bacterial ferritins General function prediction only 146304279 Nonpathogen - hypothetical protein Msed_1514 3 COG4280 COG4280, Predicted membrane protein Function unknown 146303778 Nonpathogen - hypothetical protein Msed_1002 2 None None None 146304785 Nonpathogen - GTPase or GTP-binding protein-like protein Msed_2037 15 COG1341 COG1341, Predicted GTPase or GTP-binding protein General function prediction only 146304522 Common - 6-phosphogluconate dehydrogenase, NAD-binding Msed_1759 177 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 146304817 Nonpathogen - hypothetical protein Msed_2069 2 None None None 146302998 Common - siroheme synthase Msed_0213 97 COG1648 CysG, Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) Coenzyme metabolism 146303900 Nonpathogen - hypothetical protein Msed_1130 1 COG1106 COG1106, Predicted ATPases General function prediction only 146304649 Common - NADH-ubiquinone oxidoreductase, chain 4L Msed_1901 118 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 146303087 Nonpathogen - hypothetical protein Msed_0302 4 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 146304202 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Msed_1437 19 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 146304141 Common - carboxyl transferase Msed_1375 213 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 146303811 Nonpathogen - hypothetical protein Msed_1038 1 None None None 146303035 Common - amino acid permease-associated region Msed_0250 21 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146303951 Common - amino acid permease-associated region Msed_1182 53 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146303362 Nonpathogen - hypothetical protein Msed_0579 2 None None None 146303490 Common - hypothetical protein Msed_0707 13 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 146303410 Nonpathogen - hypothetical protein Msed_0627 2 None None None 146304108 Common - ATPase involved in chromosome partitioning-like protein Msed_1342 8 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146303496 Nonpathogen - hypothetical protein Msed_0713 1 None None None 146304022 Nonpathogen - hypothetical protein Msed_1254 2 COG3427 COG3427, Uncharacterized conserved protein Function unknown 146304564 Common - translation initiation factor IF-2 subunit alpha Msed_1802 46 COG1093 SUI2, Translation initiation factor 2, alpha subunit (eIF-2alpha) Translation, ribosomal structure and biogenesis 146304137 Common - transcriptional regulator, PadR-like family Msed_1371 54 COG1695 COG1695, Predicted transcriptional regulators Transcription 146304390 Nonpathogen - 50S ribosomal protein L31e Msed_1627 2 COG2097 RPL31A, Ribosomal protein L31E Translation, ribosomal structure and biogenesis 146304527 Nonpathogen - hypothetical protein Msed_1764 2 None None None 146302934 Common - exonuclease of the beta-lactamase fold involved in RNA processing-like protein Msed_0149 68 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 146304642 Common - thymidylate synthase, flavin-dependent Msed_1894 69 COG1351 THY1, Predicted alternative thymidylate synthase Nucleotide transport and metabolism 146303924 Nonpathogen - hypothetical protein Msed_1155 1 None None None 146303489 Nonpathogen - hypothetical protein Msed_0706 2 None None None 146303136 Common - protein of unknown function DUF1641 Msed_0351 7 COG2427 COG2427, Uncharacterized conserved protein Function unknown 146303683 Common - cation diffusion facilitator family transporter Msed_0903 129 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 146304181 Nonpathogen - hypothetical protein Msed_1415 2 None None None 146304557 Nonpathogen - hypothetical protein Msed_1794 2 None None None 146304000 Nonpathogen - Peptidase A5, thermopsin Msed_1231 6 None None None 146304317 Nonpathogen - hypothetical protein Msed_1554 2 COG1458 COG1458, Predicted DNA-binding protein containing PIN domain General function prediction only 146303215 Common - isochorismatase hydrolase Msed_0430 99 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 146303148 Common - TQO small subunit DoxD Msed_0363 6 None None None 146304297 Nonpathogen - hypothetical protein Msed_1533 1 None None None 146303876 Nonpathogen - hypothetical protein Msed_1104 1 None None None 146304802 Nonpathogen - hypothetical protein Msed_2054 2 None None None 146303458 Common - CoB--CoM heterodisulfide reductase Msed_0675 49 COG2048 HdrB, Heterodisulfide reductase, subunit B Energy production and conversion 146304875 Nonpathogen - hypothetical protein Msed_2128 3 None None None 146304436 Nonpathogen - RNA polymerase Rpb6 Msed_1673 21 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 146303992 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase Msed_1223 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 146303423 Common - heat shock protein Hsp20 Msed_0640 104 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 146302786 Nonpathogen - AAA ATPase Msed_0001 31 COG1474 CDC6, Cdc6-related protein, AAA superfamily ATPase DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones 146303344 Nonpathogen - hypothetical protein Msed_0561 2 None None None 146304939 Nonpathogen - hypothetical protein Msed_2192 2 None None None 146303055 Common - acetyl-CoA acetyltransferase Msed_0270 90 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 146303280 Nonpathogen - hypothetical protein Msed_0496 6 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 146304636 Nonpathogen - hypothetical protein Msed_1888 2 None None None 146304020 Nonpathogen - major facilitator superfamily MFS_1 Msed_1252 5 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146303830 Common - Dimethylmenaquinone methyltransferase Msed_1057 55 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 146304257 Common - von Willebrand factor, type A Msed_1492 54 COG2304 COG2304, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 146303813 Common - AAA ATPase Msed_1040 37 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 146303210 Common - Undecaprenyl-diphosphatase Msed_0425 84 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 146304722 Common - Radical SAM domain protein Msed_1974 177 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 146304683 Nonpathogen - hypothetical protein Msed_1935 2 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 146303942 Nonpathogen - hypothetical protein Msed_1173 1 None None None 146304622 Common - Shikimate dehydrogenase substrate binding, N-terminal domain protein Msed_1874 210 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 146304369 Nonpathogen - hypothetical protein Msed_1606 2 None None None 146304431 Common - Phosphopyruvate hydratase Msed_1668 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 146303251 Nonpathogen - putative transcriptional regulator, CopG family Msed_0466 1 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 146304343 Nonpathogen - hypothetical protein Msed_1580 3 None None None 146304513 Common - DEAD/DEAH box helicase domain protein Msed_1750 232 COG1201 Lhr, Lhr-like helicases General function prediction only 146303802 Nonpathogen - hypothetical protein Msed_1029 2 None None None 146303843 Nonpathogen - hypothetical protein Msed_1071 2 None None None 146304516 Common - putative deoxyhypusine synthase Msed_1753 61 COG1899 DYS1, Deoxyhypusine synthase Posttranslational modification, protein turnover, chaperones 146303878 Nonpathogen - hypothetical protein Msed_1106 3 None None None 146304977 Common - Methyltransferase type 11 Msed_2231 93 COG2519 GCD14, tRNA(1-methyladenosine) methyltransferase and related methyltransferases Translation, ribosomal structure and biogenesis 146303753 Common - protein of unknown function DUF1028 Msed_0976 39 COG3342 COG3342, Uncharacterized conserved protein Function unknown 146302957 Nonpathogen - 30S ribosomal protein S8e Msed_0172 34 COG2007 RPS8A, Ribosomal protein S8E Translation, ribosomal structure and biogenesis 146303776 Nonpathogen - hypothetical protein Msed_1000 1 None None None 146303044 Nonpathogen - hypothetical protein Msed_0259 2 None None None 146304005 Common - beta-lactamase domain protein Msed_1236 58 COG1237 COG1237, Metal-dependent hydrolases of the beta-lactamase superfamily II General function prediction only 146304559 Nonpathogen - hypothetical protein Msed_1796 3 None None None 146302991 Nonpathogen - tRNA pseudouridine synthase D, TruD Msed_0206 45 COG0585 COG0585, Uncharacterized conserved protein Function unknown 146303597 Common - Anaerobic dehydrogenase typically selenocysteine-containing-like protein Msed_0814 70 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 146303342 Common - GTP:adenosylcobinamide-phosphate guanylyltransferase-like protein Msed_0559 27 COG2266 COG2266, GTP:adenosylcobinamide-phosphate guanylyltransferase Coenzyme metabolism 146304246 Common - glycine cleavage system protein H Msed_1481 162 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 146304588 Nonpathogen - hypothetical protein Msed_1827 2 None None None 146303620 Common - putative signal transduction protein with CBS domains Msed_0838 125 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 146305007 Nonpathogen - hypothetical protein Msed_2261 2 COG5131 URM1, Ubiquitin-like protein Posttranslational modification, protein turnover, chaperones 146302804 Common - AIR synthase related protein domain protein Msed_0019 175 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 146303703 Common - nickel-dependent hydrogenase, large subunit Msed_0923 97 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 146302985 Common - GMP synthase domain protein Msed_0200 240 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 146302887 Nonpathogen - KOW domain protein Msed_0102 34 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 146304859 Common - glycosyl transferase, family 2 Msed_2112 61 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 146304930 Nonpathogen - Bacterio-opsin activator, HTH domain protein Msed_2183 2 COG3413 COG3413, Predicted DNA binding protein General function prediction only 146304045 Nonpathogen - DNA polymerase, beta domain protein region Msed_1278 11 COG5260 TRF4, DNA polymerase sigma DNA replication, recombination, and repair 146303192 Common - major facilitator superfamily MFS_1 Msed_0407 127 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 146302993 Nonpathogen - protein of unknown function DUF1610 Msed_0208 23 COG2888 COG2888, Predicted Zn-ribbon RNA-binding protein with a function in translation Translation, ribosomal structure and biogenesis 146304744 Nonpathogen - hypothetical protein Msed_1996 2 None None None 146302863 Common - exosome complex RNA-binding protein Rrp42 Msed_0078 176 COG2123 COG2123, RNase PH-related exoribonuclease Translation, ribosomal structure and biogenesis 146303561 Common - protein of unknown function DUF84 Msed_0778 36 COG1986 COG1986, Uncharacterized conserved protein Function unknown 146303591 Common - TrkA-N domain protein Msed_0808 95 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 146303464 Common - geranylgeranyl reductase Msed_0681 92 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 146303323 Common - FAD dependent oxidoreductase Msed_0540 6 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 146304483 Common - glutamyl-tRNA(Gln) amidotransferase subunit D Msed_1720 135 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 146304698 Common - phosphoribosyl-AMP cyclohydrolase Msed_1950 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 146304161 Nonpathogen - hypothetical protein Msed_1395 1 None None None 146303791 Common - AMP-dependent synthetase and ligase Msed_1015 225 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 146303965 Nonpathogen - hypothetical protein Msed_1196 1 None None None 146304905 Nonpathogen - uncharacterised conserved protein UCP017998 Msed_2158 7 COG4353 COG4353, Uncharacterized conserved protein Function unknown 146304505 Nonpathogen - hypothetical protein Msed_1742 2 None None None 146304729 Common - amidophosphoribosyltransferase Msed_1981 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 146302859 Nonpathogen - proteasome subunit alpha Msed_0074 34 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 146304840 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Msed_2092 130 COG1010 CobJ, Precorrin-3B methylase Coenzyme metabolism 146303243 Nonpathogen - hypothetical protein Msed_0458 5 COG3889 COG3889, Predicted solute binding protein General function prediction only 146303765 Common - glycoside hydrolase 15-related Msed_0989 74 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 146304360 Common - thiamine pyrophosphate enzyme domain protein TPP-binding Msed_1597 102 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 146303580 Common - putative transcriptional regulator, AsnC family Msed_0797 40 COG1522 Lrp, Transcriptional regulators Transcription 146304306 Common - Heterodisulfide reductase subunit C-like protein Msed_1543 39 COG1150 HdrC, Heterodisulfide reductase, subunit C Energy production and conversion 146302864 Nonpathogen rpl37ae 50S ribosomal protein L37Ae Msed_0079 32 COG1997 RPL43A, Ribosomal protein L37AE/L43A Translation, ribosomal structure and biogenesis 146303573 Common - glycosyl transferase, family 2 Msed_0790 21 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 146304148 Common - binding-protein-dependent transport systems inner membrane component Msed_1382 211 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 146303607 Nonpathogen - hypothetical protein Msed_0824 1 None None None 146304677 Common - acetolactate synthase catalytic subunit Msed_1929 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 146305014 Common - Proteasome endopeptidase complex Msed_2268 40 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 146304250 Nonpathogen - hypothetical protein Msed_1485 3 None None None 146303116 Common - electron transfer flavoprotein beta-subunit Msed_0331 146 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 146303174 Common - 3-hydroxyacyl-CoA dehydrogenase, NAD-binding Msed_0389 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 146304854 Nonpathogen - hypothetical protein Msed_2107 2 None None None 146303585 Nonpathogen - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Msed_0802 6 COG0348 NapH, Polyferredoxin Energy production and conversion 146303289 Nonpathogen - hypothetical protein Msed_0506 2 None None None 146303825 Common - peptidase M19, renal dipeptidase Msed_1052 102 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 146303437 Common - Non-specific serine/threonine protein kinase Msed_0654 66 COG1718 RIO1, Serine/threonine protein kinase involved in cell cycle control Signal transduction mechanisms / Cell division and chromosome partitioning 146304618 Nonpathogen - 3-dehydroquinate dehydratase-like protein Msed_1870 8 COG0710 AroD, 3-dehydroquinate dehydratase Amino acid transport and metabolism 146304954 Nonpathogen - Selenocysteine-specific translation elongation factor-like protein Msed_2208 17 COG3276 SelB, Selenocysteine-specific translation elongation factor Translation, ribosomal structure and biogenesis 146303199 Nonpathogen - hypothetical protein Msed_0414 2 None None None 146304692 Common - histidine biosynthesis protein Msed_1944 213 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 146304965 Common - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Msed_2219 151 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 146303501 Common - protein of unknown function DUF340, membrane Msed_0718 49 COG2431 COG2431, Predicted membrane protein Function unknown 146303483 Common phhB pterin-4-alpha-carbinolamine dehydratase Msed_0700 114 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 146303517 Common - dTDP-4-dehydrorhamnose reductase Msed_0734 43 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 146304769 Common - putative signal-transduction protein with CBS domains Msed_2021 14 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 146302788 Common - thioesterase superfamily protein Msed_0003 128 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 146305017 Nonpathogen - hypothetical protein Msed_2271 6 None None None 146302834 Nonpathogen - GTP cyclohydrolase IIa Msed_0049 16 COG2429 COG2429, Uncharacterized conserved protein Function unknown 146302854 Common - translation-associated GTPase Msed_0069 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 146305033 Nonpathogen - Uncharacterized metal-binding protein-like protein Msed_2288 2 COG5431 COG5431, Uncharacterized metal-binding protein Function unknown 146304327 Nonpathogen - hypothetical protein Msed_1564 2 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 146303872 Nonpathogen - hypothetical protein Msed_1100 2 None None None 146303207 Nonpathogen - hypothetical protein Msed_0422 2 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 146303633 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Msed_0851 32 COG4934 COG4934, Predicted protease Posttranslational modification, protein turnover, chaperones 146303805 Nonpathogen - hypothetical protein Msed_1032 2 None None None 146304662 Common - V-type ATP synthase subunit I Msed_1914 45 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 146304699 Common - protein of unknown function DUF59 Msed_1951 148 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 146304924 Common - Resolvase helix-turn-helix domain protein Msed_2177 3 None None None 146303026 Common - NAD-dependent epimerase/dehydratase Msed_0241 144 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 146303387 Nonpathogen - amidohydrolase Msed_0604 12 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 146304474 Nonpathogen - hypothetical protein Msed_1711 4 None None None 146303982 Common - Pyruvate dehydrogenase (acetyl-transferring) Msed_1213 154 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 146303156 Nonpathogen - hypothetical protein Msed_0371 2 None None None 146304328 Nonpathogen - hypothetical protein Msed_1565 2 COG3350 COG3350, Uncharacterized conserved protein Function unknown 146303126 Nonpathogen - hypothetical protein Msed_0341 2 None None None 146304586 Nonpathogen - hypothetical protein Msed_1825 2 None None None 146303377 Nonpathogen - hypothetical protein Msed_0594 2 None None None 146304228 Nonpathogen - FAD linked oxidase domain protein Msed_1463 2 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 146303308 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Msed_0525 114 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 146303686 Common - thiamine biosynthesis protein ThiC Msed_0906 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 146303185 Common - acyl-CoA dehydrogenase domain protein Msed_0400 163 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 146302888 Nonpathogen - 30S ribosomal protein S4e Msed_0103 34 COG1471 RPS4A, Ribosomal protein S4E Translation, ribosomal structure and biogenesis 146303967 Nonpathogen - type II secretion system protein Msed_1198 6 COG1955 FlaJ, Archaeal flagella assembly protein J Cell motility and secretion / Intracellular trafficking and secretion 146304600 Common - Chromosome segregation ATPase-like protein Msed_1852 223 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 146303364 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Msed_0581 101 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 146302898 Common rpl15p 50S ribosomal protein L15P Msed_0113 36 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 146304344 Common - ATP-citrate lyase/succinyl-CoA ligase Msed_1581 218 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 146302909 Nonpathogen - protein of unknown function DUF1464 Msed_0124 7 COG2441 COG2441, Predicted butyrate kinase Energy production and conversion 146303638 Nonpathogen - hypothetical protein Msed_0857 5 None None None 146303644 Common - protein kinase Msed_0863 76 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 146302809 Common gatB aspartyl/glutamyl-tRNA amidotransferase subunit B Msed_0024 213 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 146303233 Nonpathogen - zinc finger, RanBP2-type Msed_0448 4 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 146303999 Nonpathogen - Thermopsin Msed_1230 6 None None None 146303989 Common - Vinylacetyl-CoA Delta-isomerase Msed_1220 50 COG2368 COG2368, Aromatic ring hydroxylase Secondary metabolites biosynthesis, transport, and catabolism 146304179 Nonpathogen - hypothetical protein Msed_1413 2 None None None 146302790 Common - protein of unknown function DUF62 Msed_0005 74 COG1912 COG1912, Uncharacterized conserved protein Function unknown 146302846 Nonpathogen - 50S ribosomal protein L21e Msed_0061 34 COG2139 RPL21A, Ribosomal protein L21E Translation, ribosomal structure and biogenesis 146303623 Common - beta-lactamase domain protein Msed_0841 16 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 146303373 Nonpathogen - hypothetical protein Msed_0590 2 None None None 146304187 Common - glycogen debranching enzyme, putative Msed_1421 36 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 146303733 Nonpathogen - hypothetical protein Msed_0954 2 COG0579 COG0579, Predicted dehydrogenase General function prediction only 146302792 Common - putative RNA methylase, NOL1/NOP2/sun family Msed_0007 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 146304467 Nonpathogen - hypothetical protein Msed_1704 7 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 146303299 Nonpathogen - hypothetical protein Msed_0516 2 None None None 146303740 Common - nitrite and sulphite reductase 4Fe-4S region Msed_0961 136 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 146303072 Nonpathogen - hypothetical protein Msed_0287 2 None None None 146304779 Nonpathogen - hypothetical protein Msed_2031 2 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 146303975 Common - blue (type 1) copper domain protein Msed_1206 10 COG3794 PetE, Plastocyanin Energy production and conversion 146303252 Common - major facilitator superfamily MFS_1 Msed_0467 122 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146304061 Common - ABC-1 domain protein Msed_1295 185 COG0661 AarF, Predicted unusual protein kinase General function prediction only 146304885 Nonpathogen - hypothetical protein Msed_2138 2 None None None 146302828 Common - cobyrinic acid a,c-diamide synthase Msed_0043 137 COG1797 CobB, Cobyrinic acid a,c-diamide synthase Coenzyme metabolism 146304171 Nonpathogen - hypothetical protein Msed_1405 2 COG5217 BIM1, Microtubule-binding protein involved in cell cycle control Cell division and chromosome partitioning / Cytoskeleton 146303095 Nonpathogen - major facilitator superfamily MFS_1 Msed_0310 27 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 146303595 Common - Formate-dependent nitrite reductase membrane component-like protein Msed_0812 10 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 146304834 Common - Citrate transporter Msed_2086 108 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 146304580 Nonpathogen - Bacterio-opsin activator, HTH domain protein Msed_1818 9 COG3413 COG3413, Predicted DNA binding protein General function prediction only 146304606 Nonpathogen - hypothetical protein Msed_1858 2 None None None 146302903 Common - cytidylate kinase Msed_0118 44 COG1102 Cmk, Cytidylate kinase Nucleotide transport and metabolism 146303739 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Msed_0960 202 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 146303303 Nonpathogen - hypothetical protein Msed_0520 2 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 146304300 Nonpathogen - hypothetical protein Msed_1536 7 None None None 146304165 Common - CoA-binding domain protein Msed_1399 158 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 146303021 Common - sugar isomerase (SIS) Msed_0236 45 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 146304665 Common - V-type ATP synthase subunit A Msed_1917 247 COG1155 NtpA, Archaeal/vacuolar-type H+-ATPase subunit A Energy production and conversion 146303838 Nonpathogen - hypothetical protein Msed_1066 2 None None None 146303445 Nonpathogen - TGS domain protein Msed_0662 38 COG1163 DRG, Predicted GTPase General function prediction only 146303181 Common - acetyl-CoA acetyltransferase Msed_0396 179 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 146304672 Common - SNO glutamine amidotransferase Msed_1924 85 COG0311 PDX2, Predicted glutamine amidotransferase involved in pyridoxine biosynthesis Coenzyme metabolism 146303295 Common - Radical SAM domain protein Msed_0512 139 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 146303452 Nonpathogen - single-strand DNA-binding protein Msed_0669 14 COG1599 RFA1, Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins DNA replication, recombination, and repair 146304507 Nonpathogen - hypothetical protein Msed_1744 2 None None None 146305002 Common - peptidylprolyl isomerase, FKBP-type Msed_2256 36 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 146303641 Nonpathogen - major facilitator superfamily MFS_1 Msed_0860 5 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146303343 Nonpathogen - protein of unknown function DUF1614 Msed_0560 24 COG4089 COG4089, Predicted membrane protein Function unknown 146303700 Common - Coenzyme F420-reducing hydrogenase alpha subunit-like protein Msed_0920 67 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 146303382 Nonpathogen - hypothetical protein Msed_0599 2 None None None 146303556 Common - Phosphoglycerate mutase Msed_0773 107 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 146304401 Common alaS alanyl-tRNA synthetase Msed_1638 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146304791 Common - MCM family protein Msed_2043 36 COG1241 MCM2, Predicted ATPase involved in replication control, Cdc46/Mcm family DNA replication, recombination, and repair 146303646 Nonpathogen - transcriptional regulator, AbrB family Msed_0865 6 None None None 146303487 Common - Methyltransferase type 11 Msed_0704 3 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 146303506 Common - Chlorite dismutase Msed_0723 29 COG3253 COG3253, Uncharacterized conserved protein Function unknown 146304211 Nonpathogen - protein of unknown function DUF429 Msed_1446 10 COG2410 COG2410, Uncharacterized conserved protein Function unknown 146304745 Common - protein of unknown function DUF355 Msed_1997 33 COG1839 COG1839, Uncharacterized conserved protein Function unknown 146303074 Nonpathogen - cytochrome c oxidase, subunit II Msed_0289 2 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 146304910 Common - protein-L-isoaspartate(D-aspartate) O-methyltransferase Msed_2163 152 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 146305001 Common - 3-dehydroquinate synthase Msed_2255 107 COG0371 GldA, Glycerol dehydrogenase and related enzymes Energy production and conversion 146303153 Nonpathogen - hypothetical protein Msed_0368 1 None None None 146304733 Nonpathogen - hypothetical protein Msed_1985 3 None None None 146303278 Common - amidohydrolase Msed_0493 173 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 146304621 Common - chorismate synthase Msed_1873 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 146303162 Common - hypothetical protein Msed_0377 10 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 146304612 Nonpathogen - diphthamide biosynthesis protein Msed_1864 34 COG1736 DPH2, Diphthamide synthase subunit DPH2 Translation, ribosomal structure and biogenesis 146303831 Common - hypothetical protein Msed_1058 14 None None None 146302916 Nonpathogen - hypothetical protein Msed_0131 2 None None None 146305019 Nonpathogen - protein of unknown function DUF75 Msed_2273 22 COG1938 COG1938, Archaeal enzymes of ATP-grasp superfamily General function prediction only 146302950 Common - acetylglutamate kinase Msed_0165 208 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 146304393 Nonpathogen - prefoldin subunit alpha Msed_1630 8 COG1730 GIM5, Predicted prefoldin, molecular chaperone implicated in de novo protein folding Posttranslational modification, protein turnover, chaperones 146303106 Common - Cytochrome b/b6, N-terminal domain Msed_0321 149 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 146303341 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Msed_0558 91 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 146304309 Common - protein of unknown function DUF224, cysteine-rich region domain protein Msed_1546 22 COG2048 HdrB, Heterodisulfide reductase, subunit B Energy production and conversion 146304462 Common - aspartate kinase Msed_1699 236 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 146304134 Nonpathogen - hypothetical protein Msed_1368 5 None None None 146303915 Nonpathogen - CRISPR-associated protein, Csa1 family Msed_1146 9 COG4343 COG4343, Uncharacterized protein conserved in archaea Function unknown 146304959 Common - glycyl-tRNA synthetase Msed_2213 96 COG0423 GRS1, Glycyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 146304980 Nonpathogen - 30S ribosomal protein S25e Msed_2234 8 COG4901 COG4901, Ribosomal protein S25 Translation, ribosomal structure and biogenesis 146303870 Common - protein of unknown function DUF87 Msed_1098 10 COG0433 COG0433, Predicted ATPase General function prediction only 146303110 Nonpathogen - protein of unknown function DUF1404 Msed_0325 2 None None None 146302796 Common - threonine dehydratase Msed_0011 208 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 146303121 Common - Enoyl-CoA hydratase/isomerase Msed_0336 169 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 146304851 Nonpathogen - hypothetical protein Msed_2103 2 None None None 146304452 Common - anthranilate phosphoribosyltransferase Msed_1689 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 146304993 Nonpathogen rps15p 30S ribosomal protein S15P Msed_2247 34 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 146304693 Common - Imidazoleglycerol-phosphate dehydratase Msed_1945 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 146303167 Nonpathogen - hypothetical protein Msed_0382 2 None None None 146303588 Common - ABC transporter related Msed_0805 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 146304325 Common - CoA-binding domain protein Msed_1562 147 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 146304773 Common - putative ATP binding protein Msed_2025 47 COG2102 COG2102, Predicted ATPases of PP-loop superfamily General function prediction only 146303284 Common - Cytochrome b/b6, N-terminal domain Msed_0500 142 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 146303883 Nonpathogen - hypothetical protein Msed_1112 1 None None None 146303627 Nonpathogen - type I phosphodiesterase/nucleotide pyrophosphatase Msed_0845 11 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 146302942 Nonpathogen - protein of unknown function DUF814 Msed_0157 35 COG1293 COG1293, Predicted RNA-binding protein homologous to eukaryotic snRNP Transcription 146304080 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Msed_1314 229 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 146302803 Common - adenylosuccinate lyase Msed_0018 239 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 146303244 Nonpathogen - hypothetical protein Msed_0459 3 None None None 146303494 Common - dihydroxy-acid dehydratase Msed_0711 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 146302852 Nonpathogen - 30S ribosomal protein S3Ae Msed_0067 34 COG1890 RPS1A, Ribosomal protein S3AE Translation, ribosomal structure and biogenesis 146304868 Common - competence damage-inducible protein A Msed_2121 166 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 146303047 Nonpathogen - hypothetical protein Msed_0262 2 None None None 146304861 Nonpathogen - hypothetical protein Msed_2114 3 COG1310 COG1310, Predicted metal-dependent protease of the PAD1/JAB1 superfamily General function prediction only 146303769 Common - major facilitator superfamily MFS_1 Msed_0993 125 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146303253 Common - putative signal-transduction protein with CBS domains Msed_0468 50 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 146302865 Nonpathogen - exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component contains IMP4 domain-like protein Msed_0080 2 COG2136 IMP4, Predicted exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component, contains IMP4 domain Translation, ribosomal structure and biogenesis / RNA processing and modification 146304898 Nonpathogen - hypothetical protein Msed_2151 2 None None None 146304519 Common - translation initiation factor IF-5A Msed_1756 41 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 146304428 Common - glycine dehydrogenase subunit 2 Msed_1665 172 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 146302882 Common rps3p 30S ribosomal protein S3P Msed_0097 248 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 146304364 Common - Anticodon-binding domain protein Msed_1601 204 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146303480 Nonpathogen - protein of unknown function DUF107 Msed_0697 14 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 146303460 Common sdhA succinate dehydrogenase flavoprotein subunit Msed_0677 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 146303040 Common - major facilitator superfamily MFS_1 Msed_0255 203 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146303990 Nonpathogen - Bacterio-opsin activator, HTH domain protein Msed_1221 2 COG3413 COG3413, Predicted DNA binding protein General function prediction only 146304555 Nonpathogen - Proliferating cell nuclear antigen, PCNA Msed_1792 34 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 146304247 Nonpathogen - protein of unknown function DUF123 Msed_1482 13 COG1833 COG1833, Uncharacterized conserved protein Function unknown 146303997 Nonpathogen - Sulfolobus transposase Msed_1228 2 None None None 146304645 Common - NADH dehydrogenase subunit D Msed_1897 191 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 146304800 Common - Proteasome endopeptidase complex Msed_2052 48 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 146304118 Common - GPR1/FUN34/yaaH family protein Msed_1352 49 COG1584 COG1584, Predicted membrane protein Function unknown 146303757 Common - dTMP kinase Msed_0980 137 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 146303538 Common - Amidase Msed_0755 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 146303311 Nonpathogen - hypothetical protein Msed_0528 2 None None None 146303858 Nonpathogen - protein of unknown function DUF105 Msed_1086 5 COG1865 COG1865, Uncharacterized conserved protein Function unknown 146304578 Common - glycosyl transferase, family 2 Msed_1816 145 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 146303760 Nonpathogen - hypothetical protein Msed_0983 2 None None None 146303622 Nonpathogen - hypothetical protein Msed_0840 2 None None None 146303196 Nonpathogen - PilT protein domain protein Msed_0411 7 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 146304900 Nonpathogen - DNA primase Msed_2153 34 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 146304446 Common valS valyl-tRNA synthetase Msed_1683 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146303694 Common - ATPase involved in chromosome partitioning-like protein Msed_0914 128 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146302835 Common - amidohydrolase Msed_0050 63 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 146303317 Common purT phosphoribosylglycinamide formyltransferase 2 Msed_0534 235 COG0027 PurT, Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) Nucleotide transport and metabolism 146303329 Common - DEAD/DEAH box helicase domain protein Msed_0546 236 COG1205 COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster General function prediction only 146304042 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Msed_1274 11 COG0348 NapH, Polyferredoxin Energy production and conversion 146302971 Common - beta-lactamase domain protein Msed_0186 52 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 146303943 Common - Penicillin amidase Msed_1174 71 COG2366 COG2366, Protein related to penicillin acylase General function prediction only 146303320 Nonpathogen - hypothetical protein Msed_0537 9 None None None 146303801 Nonpathogen - hypothetical protein Msed_1025 1 None None None 146302949 Common argC N-acetyl-gamma-glutamyl-phosphate reductase Msed_0164 199 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 146304964 Nonpathogen - hypothetical protein Msed_2218 7 None None None 146304512 Nonpathogen - Alba, DNA/RNA-binding protein Msed_1749 10 COG1581 Ssh10b, Archaeal DNA-binding protein Transcription 146303565 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Msed_0782 120 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 146304383 Nonpathogen - hypothetical protein Msed_1620 2 None None None 146304888 Nonpathogen - DNA-directed RNA polymerase subunit N Msed_2141 34 COG1644 RPB10, DNA-directed RNA polymerase, subunit N (RpoN/RPB10) Transcription 146303865 Nonpathogen - hypothetical protein Msed_1093 4 None None None 146304686 Common - PP-loop domain protein Msed_1938 130 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 146302963 Nonpathogen - hypothetical protein Msed_0178 3 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 146303203 Common - protein of unknown function DUF72 Msed_0418 74 COG1801 COG1801, Uncharacterized conserved protein Function unknown 146303378 Common - NUDIX hydrolase Msed_0595 55 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 146304561 Nonpathogen - hypothetical protein Msed_1798 1 None None None 146303606 Nonpathogen - hypothetical protein Msed_0823 2 None None None 146304036 Common - NAD(+) kinase Msed_1268 230 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 146304318 Nonpathogen - protein of unknown function DUF1641 Msed_1555 2 None None None 146304909 Common - major facilitator superfamily MFS_1 Msed_2162 131 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 146304256 Common - metallophosphoesterase Msed_1491 19 None None None 146304633 Common - glutamate synthase, alpha subunit domain protein Msed_1885 98 COG0067 GltB, Glutamate synthase domain 1 Amino acid transport and metabolism 146304828 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Msed_2080 247 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 146304475 Nonpathogen - hypothetical protein Msed_1712 5 None None None 146303726 Nonpathogen - hypothetical protein Msed_0946 5 COG2181 NarI, Nitrate reductase gamma subunit Energy production and conversion 146303909 Nonpathogen - CRISPR-associated HD domain protein Msed_1140 3 COG2254 COG2254, Predicted HD superfamily hydrolase, possibly a nuclease DNA replication, recombination, and repair 146304933 Common - transposase IS200-family protein Msed_2186 72 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 146304500 Nonpathogen - protein of unknown function DUF120 Msed_1737 34 COG1339 COG1339, Transcriptional regulator of a riboflavin/FAD biosynthetic operon Transcription / Coenzyme metabolism 146303360 Nonpathogen - hypothetical protein Msed_0577 3 None None None 146303417 Common - AAA ATPase, central domain protein Msed_0634 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 146304524 Common - short-chain dehydrogenase/reductase SDR Msed_1761 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 146302917 Nonpathogen - hypothetical protein Msed_0132 1 None None None 146304395 Nonpathogen secE preprotein translocase subunit SecE Msed_1632 2 COG2443 Sss1, Preprotein translocase subunit Sss1 Intracellular trafficking and secretion 146304347 Nonpathogen - Glycosyltransferase 28, C-terminal domain Msed_1584 7 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 146304919 Common - nucleotide kinase-like protein Msed_2172 34 COG1936 COG1936, Predicted nucleotide kinase (related to CMP and AMP kinases) Nucleotide transport and metabolism 146302947 Common - hypothetical protein Msed_0162 11 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 146304296 Common - TPR repeat-containing protein Msed_1532 83 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 146303456 Common - hypothetical protein Msed_0673 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 146304727 Common - phosphoribosylformylglycinamidine synthase I Msed_1979 232 COG0047 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain Nucleotide transport and metabolism 146303187 Common - peptidase U62, modulator of DNA gyrase Msed_0402 63 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 146303888 Common - major facilitator superfamily MFS_1 Msed_1117 135 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146303608 Nonpathogen - hypothetical protein Msed_0825 1 None None None 146303217 Common - acetolactate synthase catalytic subunit Msed_0432 215 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 146304529 Nonpathogen - PaREP1 domain containing protein Msed_1766 2 None None None 146303297 Common - peptidase U32 Msed_0514 10 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 146302902 Nonpathogen - ribosomal protein L34e Msed_0117 13 COG2174 RPL34A, Ribosomal protein L34E Translation, ribosomal structure and biogenesis 146302910 Nonpathogen - hypothetical protein Msed_0125 6 COG1665 COG1665, Uncharacterized protein conserved in archaea Function unknown 146303558 Common - FAD dependent oxidoreductase Msed_0775 3 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 146304921 Nonpathogen - hypothetical protein Msed_2174 2 None None None 146304193 Common - hydrogenase 4 subunit F Msed_1428 209 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 146304334 Nonpathogen - hypothetical protein Msed_1571 2 None None None 146302844 Nonpathogen - hypothetical protein Msed_0059 2 None None None 146303746 Nonpathogen - hypothetical protein Msed_0968 2 None None None 146303433 Common - type II secretion system protein E Msed_0650 227 COG0630 VirB11, Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis Cell motility and secretion / Intracellular trafficking and secretion 146304813 Common - iron dependent repressor Msed_2065 68 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 146304651 Common - NADH dehydrogenase subunit N Msed_1903 209 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 146303128 Common - hypothetical protein Msed_0343 48 COG2848 COG2848, Uncharacterized conserved protein Function unknown 146303798 Nonpathogen - hypothetical protein Msed_1022 5 None None None 146303785 Common - protein of unknown function DUF35 Msed_1009 14 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 146304385 Nonpathogen - SpoVT/AbrB domain protein Msed_1622 26 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 146303142 Common - Cl- channel, voltage-gated family protein Msed_0357 165 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 146304940 Nonpathogen - hypothetical protein Msed_2193 2 None None None 146302956 Common - undecaprenyl diphosphate synthase Msed_0171 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 146303290 Common - pyruvate/ketoisovalerate oxidoreductase, gamma subunit Msed_0507 77 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 146303406 Common aksA trans-homoaconitate synthase Msed_0623 216 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 146304809 Nonpathogen - P-loop ATPase/GTPase-like protein Msed_2061 9 COG4028 COG4028, Predicted P-loop ATPase/GTPase General function prediction only 146302837 Nonpathogen - hypothetical protein Msed_0052 2 None None None 146304788 Common - hypothetical protein Msed_2040 37 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 146303462 Nonpathogen - hypothetical protein Msed_0679 2 None None None 146303076 Common - Cytochrome b/b6, N-terminal domain Msed_0291 149 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 146303429 Common - phosphomethylpyrimidine kinase Msed_0646 222 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 146303881 Nonpathogen - transposase, IS605 OrfB family Msed_1110 12 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 146303680 Nonpathogen - hypothetical protein Msed_0900 3 None None None 146304029 Nonpathogen - peptidase S26B, signal peptidase Msed_1261 9 None None None 146304881 Nonpathogen - glycosyl transferase, family 4 Msed_2134 13 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 146303603 Common - MscS Mechanosensitive ion channel Msed_0820 36 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 146304415 Nonpathogen - glyceraldehyde-3-phosphate dehydrogenase Msed_1652 38 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 146303197 Nonpathogen - hypothetical protein Msed_0412 2 None None None 146303049 Common - thioesterase superfamily protein Msed_0264 30 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 146305035 Nonpathogen - protein of unknown function DUF701, zinc-binding putative Msed_2290 7 COG4888 COG4888, Uncharacterized Zn ribbon-containing protein General function prediction only 146303824 Common - ATPase Msed_1051 33 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 146303954 Nonpathogen - hypothetical protein Msed_1185 13 COG2430 COG2430, Uncharacterized conserved protein Function unknown 146304450 Common - anthranilate synthase component I Msed_1687 223 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 146304719 Common - pyridine nucleotide-disulphide oxidoreductase dimerisation region Msed_1971 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 146303920 Nonpathogen - CRISPR locus-related DNA-binding protein Msed_1151 3 None None None 146303927 Nonpathogen - hypothetical protein Msed_1158 3 None None None 146304034 Nonpathogen - hypothetical protein Msed_1266 2 None None None 146303367 Nonpathogen - hypothetical protein Msed_0584 17 COG2248 COG2248, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 146302825 Common - 30S ribosomal protein S7P Msed_0040 212 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 146303062 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Msed_0277 109 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 146304292 Common - protein of unknown function DUF214 Msed_1528 175 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 146303313 Nonpathogen - hypothetical protein Msed_0530 1 None None None 146304455 Common - acylphosphatase Msed_1692 144 COG1254 AcyP, Acylphosphatases Energy production and conversion 146304236 Common - coenzyme A transferase Msed_1471 34 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 146303475 Common - alpha-L-glutamate ligase, RimK family Msed_0692 114 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 146304018 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Msed_1250 48 COG2440 FixX, Ferredoxin-like protein Energy production and conversion 146304286 Common - 2-methylcitrate synthase/citrate synthase II Msed_1522 194 COG0372 GltA, Citrate synthase Energy production and conversion 146304952 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Msed_2206 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 146303899 Nonpathogen - hypothetical protein Msed_1129 1 None None None 146304065 Nonpathogen - hypothetical protein Msed_1299 2 None None None 146303995 Common - cob(II)yrinic acid a,c-diamide reductase Msed_1226 113 COG0778 NfnB, Nitroreductase Energy production and conversion 146304129 Common - FAD dependent oxidoreductase Msed_1363 42 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 146304849 Common - cobalamin biosynthesis protein CbiD Msed_2101 95 COG1903 CbiD, Cobalamin biosynthesis protein CbiD Coenzyme metabolism 146304184 Common - Alpha-amylase Msed_1418 23 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 146302877 Nonpathogen rpl4lp 50S ribosomal protein L4P Msed_0092 34 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 146303890 Common - aldehyde dehydrogenase Msed_1119 222 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 146302813 Nonpathogen - ribosomal protein L24E Msed_0028 29 COG2075 RPL24A, Ribosomal protein L24E Translation, ribosomal structure and biogenesis 146302933 Common - biotin/lipoyl attachment domain-containing protein Msed_0148 187 COG1038 PycA, Pyruvate carboxylase Energy production and conversion 146304623 Common aroB 3-dehydroquinate synthase Msed_1875 206 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 146303351 Common - ABC transporter related Msed_0568 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 146303934 Nonpathogen - hypothetical protein Msed_1165 3 None None None 146303754 Common - pyrroline-5-carboxylate reductase Msed_0977 215 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 146303815 Common - malate synthase Msed_1042 54 COG2225 AceB, Malate synthase Energy production and conversion 146303545 Common - SMC domain protein Msed_0762 149 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 146303190 Common - metal-dependent hydrolase Msed_0405 34 COG2872 COG2872, Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain General function prediction only 146303532 Nonpathogen - peptide chain release factor 1 Msed_0749 34 COG1503 eRF1, Peptide chain release factor 1 (eRF1) Translation, ribosomal structure and biogenesis 146304533 Nonpathogen - hypothetical protein Msed_1770 1 None None None 146302891 Common rps8p 30S ribosomal protein S8P Msed_0106 201 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 146304871 Common pheS phenylalanyl-tRNA synthetase subunit alpha Msed_2124 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 146304589 Common - glycosyl transferase, family 2 Msed_1829 24 None None None 146304215 Common - N-terminal domain of molybdenum-binding protein-like protein Msed_1450 40 COG2005 ModE, N-terminal domain of molybdenum-binding protein General function prediction only 146304096 Nonpathogen - flagellin-like protein Msed_1330 2 COG1681 FlaB, Archaeal flagellins Cell motility and secretion 146303913 Nonpathogen - CRISPR-associated protein, Csa5 family Msed_1144 2 None None None 146303282 Common - 5-formyltetrahydrofolate cyclo-ligase Msed_0498 28 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 146304464 Common - PHP C-terminal domain protein Msed_1701 41 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 146303227 Nonpathogen - hypothetical protein Msed_0442 2 None None None 146304074 Nonpathogen - transcriptional regulator, AbrB family Msed_1308 6 None None None 146303973 Common - major facilitator superfamily MFS_1 Msed_1204 10 None None None 146302983 Nonpathogen - cobalamin-5-phosphate synthase CobS Msed_0198 12 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 146304274 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Msed_1509 239 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 146304775 Nonpathogen - transcriptional regulator, TrmB Msed_2027 3 COG3355 COG3355, Predicted transcriptional regulator Transcription 146303906 Nonpathogen - hypothetical protein Msed_1137 2 COG5551 COG5551, Uncharacterized conserved protein Function unknown 146303841 Nonpathogen - hypothetical protein Msed_1069 2 None None None 146304121 Nonpathogen - major facilitator superfamily MFS_1 Msed_1355 5 None None None 146304545 Nonpathogen - hypothetical protein Msed_1782 4 None None None 146304050 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Msed_1283 203 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 146305026 Common - DNA-cytosine methyltransferase Msed_2280 121 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 146304949 Common - extracellular solute-binding protein, family 5 Msed_2203 73 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 146303249 Common - Alcohol dehydrogenase GroES domain protein Msed_0464 171 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 146303650 Common - ABC transporter related Msed_0869 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 146304373 Common - peptidase M24 Msed_1610 248 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 146304139 Common - amino acid permease-associated region Msed_1373 23 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146303119 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Msed_0334 100 COG2440 FixX, Ferredoxin-like protein Energy production and conversion 146304178 Common - Pyruvate kinase Msed_1412 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 146304832 Common - thioesterase superfamily protein Msed_2084 98 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 146304265 Nonpathogen - hypothetical protein Msed_1500 2 None None None 146303001 Common - glutamate-1-semialdehyde-2,1-aminomutase Msed_0216 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 146303392 Common - molybdopterin dehydrogenase, FAD-binding Msed_0609 102 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 146302878 Common - ribosomal protein L25/L23 Msed_0093 38 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 146303712 Nonpathogen - hypothetical protein Msed_0932 1 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 146304609 Nonpathogen - hypothetical protein Msed_1861 1 None None None 154819280 Common - metal dependent phosphohydrolase Msed_2129 88 COG1078 COG1078, HD superfamily phosphohydrolases General function prediction only 146304354 Nonpathogen - hypothetical protein Msed_1591 3 COG3431 COG3431, Predicted membrane protein Function unknown 146302921 Nonpathogen - hypothetical protein Msed_0136 2 None None None 146304403 Nonpathogen - hypothetical protein Msed_1640 2 None None None 146304926 Nonpathogen - Conserved protein implicated in secretion-like protein Msed_2179 7 COG5491 VPS24, Conserved protein implicated in secretion Cell motility and secretion 146303334 Nonpathogen - SpoVT/AbrB domain protein Msed_0551 16 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 146302997 Nonpathogen - flap endonuclease-1 Msed_0212 34 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 146303701 Nonpathogen - hypothetical protein Msed_0921 1 None None None 146303108 Nonpathogen - Sulfocyanin Msed_0323 3 COG4454 COG4454, Uncharacterized copper-binding protein Inorganic ion transport and metabolism 146304664 Nonpathogen - H+-transporting two-sector ATPase, E subunit Msed_1916 10 COG1390 NtpE, Archaeal/vacuolar-type H+-ATPase subunit E Energy production and conversion 146303678 Nonpathogen - hypothetical protein Msed_0898 2 None None None 146304825 Common cysS cysteinyl-tRNA synthetase Msed_2077 242 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146303656 Common - phosphoesterase Msed_0876 27 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 146303276 Common - YHS domain protein Msed_0491 42 COG3350 COG3350, Uncharacterized conserved protein Function unknown 146303336 Common - FAD linked oxidase domain protein Msed_0553 202 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 146303137 Nonpathogen - hypothetical protein Msed_0352 3 COG2210 COG2210, Uncharacterized conserved protein Function unknown 146304703 Nonpathogen - DNA-directed RNA polymerase, M/15 kDa subunit Msed_1955 9 COG1594 RPB9, DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS Transcription 146304109 Common - hypothetical protein Msed_1343 7 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146303515 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Msed_0732 49 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 146303413 Nonpathogen - hypothetical protein Msed_0630 1 None None None 146303402 Common - putative transcriptional regulator, AsnC family Msed_0619 20 COG1522 Lrp, Transcriptional regulators Transcription 146304490 Nonpathogen - hypothetical protein Msed_1727 4 COG3888 COG3888, Predicted transcriptional regulator Transcription 146304598 Common - dTDP-glucose 4,6-dehydratase Msed_1850 232 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 146302857 Nonpathogen - hypothetical protein Msed_0072 2 COG1603 RPP1, RNase P/RNase MRP subunit p30 Translation, ribosomal structure and biogenesis 146304950 Common - binding-protein-dependent transport systems inner membrane component Msed_2204 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 146305041 Nonpathogen - domain of unknown function DUF1743 Msed_2296 33 COG1571 COG1571, Predicted DNA-binding protein containing a Zn-ribbon domain General function prediction only 146304912 Nonpathogen - hypothetical protein Msed_2165 2 None None None 146303112 Nonpathogen - hypothetical protein Msed_0327 1 None None None 146304957 Nonpathogen rpoP DNA-directed RNA polymerase subunit P Msed_2211 5 COG1996 RPC10, DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger) Transcription 146304614 Nonpathogen - thioredoxin/glutaredoxin-like protein Msed_1866 4 COG5494 COG5494, Predicted thioredoxin/glutaredoxin Posttranslational modification, protein turnover, chaperones 146303365 Common - protein of unknown function DUF790 Msed_0582 23 COG3372 COG3372, Uncharacterized conserved protein Function unknown 146303590 Common - periplasmic binding protein Msed_0807 73 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 146303472 Common - 5'-methylthioadenosine phosphorylase II Msed_0689 145 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 146303023 Nonpathogen - hypothetical protein Msed_0238 4 None None None 146304459 Nonpathogen - hypothetical protein Msed_1696 1 None None None 146304434 Nonpathogen - Conserved protein implicated in secretion-like protein Msed_1671 7 COG5491 VPS24, Conserved protein implicated in secretion Cell motility and secretion 146303894 Common - D-galactarate dehydratase/Altronate hydrolase domain protein Msed_1124 73 COG2721 UxaA, Altronate dehydratase Carbohydrate transport and metabolism 146303380 Common - PfkB domain protein Msed_0597 142 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 146304731 Common - phosphoribosylamine--glycine ligase Msed_1983 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 146304747 Common - Radical SAM domain protein Msed_1999 85 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 146303867 Common - major facilitator superfamily MFS_1 Msed_1095 198 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146303750 Nonpathogen - hypothetical protein Msed_0973 8 None None None 146304962 Nonpathogen - hypothetical protein Msed_2216 7 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 146303808 Common - phosphoesterase Msed_1035 35 COG3511 PlcC, Phospholipase C Cell envelope biogenesis, outer membrane 146305013 Common hisS histidyl-tRNA synthetase Msed_2267 249 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146303518 Common - hypothetical protein Msed_0735 40 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 146303018 Nonpathogen - protein of unknown function RIO1 Msed_0233 34 COG0478 COG0478, RIO-like serine/threonine protein kinase fused to N-terminal HTH domain Signal transduction mechanisms 146304619 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Msed_1871 228 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 146303614 Nonpathogen - hypothetical protein Msed_0831 2 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 146303165 Nonpathogen - hypothetical protein Msed_0380 1 None None None 146302976 Common - ornithine cyclodeaminase/mu-crystallin Msed_0191 93 COG2423 COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog Amino acid transport and metabolism 162149625 Common leuS leucyl-tRNA synthetase Msed_1940 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146304656 Nonpathogen - hypothetical protein Msed_1908 7 COG5399 COG5399, Uncharacterized protein conserved in archaea Function unknown 146303160 Nonpathogen - hypothetical protein Msed_0375 2 None None None 146304995 Common - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Msed_2249 22 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 146303648 Nonpathogen - hypothetical protein Msed_0867 2 None None None 146303904 Common - permease for cytosine/purine, uracil, thiamine, allantoin Msed_1135 23 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 146303093 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Msed_0308 139 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 146304763 Nonpathogen - hypothetical protein Msed_2015 5 None None None 146304089 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Msed_1323 132 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 146303419 Common - type I phosphodiesterase/nucleotide pyrophosphatase Msed_0636 28 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 146304604 Nonpathogen - bifunctional phosphoglucose/phosphomannose isomerase Msed_1856 17 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 146303183 Common - Alcohol dehydrogenase GroES domain protein Msed_0398 194 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 146302805 Common - Radical SAM domain protein Msed_0020 96 COG1964 COG1964, Predicted Fe-S oxidoreductases General function prediction only 146304667 Common - V-type ATP synthase subunit D Msed_1919 43 COG1394 NtpD, Archaeal/vacuolar-type H+-ATPase subunit D Energy production and conversion 146303986 Common - Acetyl-CoA hydrolase Msed_1217 93 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 146303737 Nonpathogen - protein of unknown function DUF650, N-terminal domain Msed_0958 32 COG1602 COG1602, Uncharacterized conserved protein Function unknown 146303042 Common - protein of unknown function DUF699, ATPase putative Msed_0257 48 COG1444 COG1444, Predicted P-loop ATPase fused to an acetyltransferase General function prediction only 146303575 Nonpathogen - hypothetical protein Msed_0792 2 None None None 146303255 Common - Vesicle-fusing ATPase Msed_0470 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 146303836 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Msed_1064 105 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 146302954 Common - acetylornithine and succinylornithine aminotransferase Msed_0169 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 146303104 Nonpathogen - hypothetical protein Msed_0319 2 None None None 146303450 Common - von Willebrand factor, type A Msed_0667 26 COG2425 COG2425, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 146303642 Nonpathogen - hypothetical protein Msed_0861 2 None None None 146304553 Common - ribose-phosphate pyrophosphokinase Msed_1790 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 146303780 Common - Isoprenylcysteine carboxyl methyltransferase Msed_1004 68 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 146304674 Nonpathogen - holliday junction resolvase Msed_1926 21 COG1591 COG1591, Holliday junction resolvase - archaeal type DNA replication, recombination, and repair 146304568 Common - hypothetical protein Msed_1806 45 None None None 146303971 Common - putative transcriptional regulator, AsnC family Msed_1202 118 COG1522 Lrp, Transcriptional regulators Transcription 146304072 Common - glycosyl transferase, group 1 Msed_1306 37 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 146303273 Nonpathogen - HEPN domain protein Msed_0488 10 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 146304858 Nonpathogen - ParB domain protein nuclease Msed_2111 10 COG1475 Spo0J, Predicted transcriptional regulators Transcription 146304499 Common - cytidyltransferase-related domain Msed_1736 150 COG0615 TagD, Cytidylyltransferase Cell envelope biogenesis, outer membrane / Lipid metabolism 146303960 Common - Rieske (2Fe-2S) domain protein Msed_1191 59 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 146304653 Nonpathogen - hypothetical protein Msed_1905 5 None None None 146303955 Common - MscS Mechanosensitive ion channel Msed_1186 183 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 146303504 Nonpathogen - protein of unknown function DUF265 Msed_0721 18 COG1618 COG1618, Predicted nucleotide kinase Nucleotide transport and metabolism 146304836 Common - Magnesium chelatase Msed_2088 113 COG1239 ChlI, Mg-chelatase subunit ChlI Coenzyme metabolism 146305010 Common - thermosome Msed_2264 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 146303907 Common - ATPase (AAA+ superfamily)-like protein Msed_1138 53 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 146304782 Nonpathogen - hypothetical protein Msed_2034 28 COG1698 COG1698, Uncharacterized protein conserved in archaea Function unknown 146303348 Common - transcriptional regulator, PadR-like family Msed_0565 78 COG1695 COG1695, Predicted transcriptional regulators Transcription 146304469 Nonpathogen - hypothetical protein Msed_1706 4 None None None 146302978 Nonpathogen - PUA domain containing protein Msed_0193 32 COG2016 COG2016, Predicted RNA-binding protein (contains PUA domain) Translation, ribosomal structure and biogenesis 146303385 Common - glutamine synthetase, catalytic region Msed_0602 223 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 146304048 Nonpathogen - hypothetical protein Msed_1281 4 None None None 146303204 Common - major facilitator superfamily MFS_1 Msed_0419 55 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 146303945 Nonpathogen - carbon monoxide dehydrogenase subunit G Msed_1176 7 COG3427 COG3427, Uncharacterized conserved protein Function unknown 146302965 Common - protein of unknown function UPF0126 Msed_0180 133 COG2860 COG2860, Predicted membrane protein Function unknown 146304388 Nonpathogen - hypothetical protein Msed_1625 33 COG2118 COG2118, DNA-binding protein General function prediction only 146303789 Common - major facilitator superfamily MFS_1 Msed_1013 27 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 146304351 Nonpathogen - hypothetical protein Msed_1588 2 None None None 146303006 Nonpathogen - hypothetical protein Msed_0221 12 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 146303286 Nonpathogen - hypothetical protein Msed_0503 2 None None None 146304935 Nonpathogen - hypothetical protein Msed_2188 2 COG1030 NfeD, Membrane-bound serine protease (ClpP class) Posttranslational modification, protein turnover, chaperones 146304146 Common - ABC transporter related Msed_1380 244 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 146304725 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase Msed_1977 211 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 146304758 Common - biotin--acetyl-CoA-carboxylase ligase Msed_2010 206 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 146303634 Common - major facilitator superfamily MFS_1 Msed_0852 76 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 146303710 Common - hydrogenase formation HypD protein Msed_0930 109 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 146303484 Nonpathogen - AAA ATPase Msed_0701 31 COG1474 CDC6, Cdc6-related protein, AAA superfamily ATPase DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones 146304040 Common - protein of unknown function DUF302 Msed_1272 34 COG3439 COG3439, Uncharacterized conserved protein Function unknown 146304168 Nonpathogen - hypothetical protein Msed_1402 2 None None None 146303327 Nonpathogen - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Msed_0544 3 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 146304631 Nonpathogen - hypothetical protein Msed_1883 2 None None None 146304502 Common - glutamyl-tRNA(Gln) amidotransferase, A subunit Msed_1739 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 146303401 Common - ABC-type Na+ efflux pump permease component-like protein Msed_0618 8 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 146304477 Nonpathogen - hypothetical protein Msed_1714 2 None None None 146304038 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Msed_1270 107 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 146304582 Nonpathogen - hypothetical protein Msed_1820 1 None None None 146304907 Nonpathogen - peptidase M50 Msed_2160 32 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 146304424 Nonpathogen - protein of unknown function DUF75 Msed_1661 33 COG1938 COG1938, Archaeal enzymes of ATP-grasp superfamily General function prediction only 146303305 Common - protein of unknown function DUF125, transmembrane Msed_0522 44 COG1814 COG1814, Uncharacterized membrane protein Function unknown 146302867 Nonpathogen - prefoldin subunit beta Msed_0082 16 COG1382 GimC, Prefoldin, chaperonin cofactor Posttranslational modification, protein turnover, chaperones 146303441 Nonpathogen - translation initiation factor IF-2 subunit beta Msed_0658 34 COG1601 GCD7, Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain Translation, ribosomal structure and biogenesis 146303246 Common - amino acid permease-associated region Msed_0461 149 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 146304454 Common - tryptophan synthase subunit beta Msed_1691 224 COG1350 COG1350, Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) General function prediction only 146303624 Nonpathogen - hypothetical protein Msed_0842 1 None None None 146303978 Common - putative transcriptional regulator, AsnC family Msed_1209 129 COG1522 Lrp, Transcriptional regulators Transcription 146304426 Common gcvT glycine cleavage system aminomethyltransferase T Msed_1663 178 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 146304322 Common - Radical SAM domain protein Msed_1559 17 COG1856 COG1856, Uncharacterized homolog of biotin synthetase Function unknown 146303194 Common - amino acid permease-associated region Msed_0409 125 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146302868 Common - ERCC4 domain protein Msed_0083 35 COG1948 MUS81, ERCC4-type nuclease DNA replication, recombination, and repair 146304863 Nonpathogen - hypothetical protein Msed_2116 9 COG4879 COG4879, Uncharacterized protein conserved in archaea Function unknown 146303513 Common - SPP-like hydrolase Msed_0730 10 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 146304891 Nonpathogen - 50S ribosomal protein L18e Msed_2144 34 COG1727 RPL18A, Ribosomal protein L18E Translation, ribosomal structure and biogenesis 146303578 Common - Sec-independent protein translocase, TatC subunit Msed_0795 205 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 146304509 Nonpathogen - hypothetical protein Msed_1746 6 None None None 146303725 Common - Ni Fe-hydrogenase I large subunit-like protein Msed_0945 59 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 146303672 Common - putative transcriptional regulator, GntR family Msed_0892 230 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 146304715 Nonpathogen - hypothetical protein Msed_1967 4 None None None 146304439 Common - N-glycosylase/DNA lyase Msed_1676 16 COG1059 COG1059, Thermostable 8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 146304975 Nonpathogen - hypothetical protein Msed_2229 3 COG1527 NtpC, Archaeal/vacuolar-type H+-ATPase subunit C Energy production and conversion 146304249 Common - hypothetical protein Msed_1484 192 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 146303693 Common - hydrogenase expression/synthesis, HypA Msed_0913 15 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 146304996 Nonpathogen - proliferating cell nuclear antigen PcnA Msed_2250 29 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 146303593 Nonpathogen - hypothetical protein Msed_0810 2 COG1414 IclR, Transcriptional regulator Transcription 146304311 Common - SirA family protein Msed_1548 122 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 146302940 Common - protein of unknown function DUF82 Msed_0155 44 COG1656 COG1656, Uncharacterized conserved protein Function unknown 146302850 Common - putative methylase Msed_0065 66 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 146303629 Common - cobalt transport protein Msed_0847 22 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 146304448 Common - Indole-3-glycerol-phosphate synthase Msed_1685 219 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 146305004 Common - putative ATPase RIL Msed_2258 249 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 146303759 Common - phosphohistidine phosphatase, SixA Msed_0982 106 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 146303988 Common - amidohydrolase Msed_1219 84 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 146304969 Nonpathogen - ribosomal protein S27a Msed_2223 7 COG1998 RPS31, Ribosomal protein S27AE Translation, ribosomal structure and biogenesis 146302830 Nonpathogen - hypothetical protein Msed_0045 1 None None None 146303856 Nonpathogen - hypothetical protein Msed_1084 1 None None None 146304878 Common gltX glutamyl-tRNA synthetase Msed_2131 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 146303015 Nonpathogen - Like-Sm ribonucleoprotein, core Msed_0230 22 COG1958 LSM1, Small nuclear ribonucleoprotein (snRNP) homolog Transcription 146303256 Nonpathogen - hypothetical protein Msed_0471 1 None None None 146303826 Common - GCN5-related N-acetyltransferase Msed_1053 35 COG3153 COG3153, Predicted acetyltransferase General function prediction only 146303004 Nonpathogen - hypothetical protein Msed_0219 1 None None None 146304098 Nonpathogen - hypothetical protein Msed_1332 2 None None None 146303355 Common - Radical SAM domain protein Msed_0572 47 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 146304234 Nonpathogen - tRNA (guanine-N1-)-methyltransferase Msed_1469 12 COG2419 COG2419, Uncharacterized conserved protein Function unknown 146304982 Common - reverse gyrase Msed_2236 240 COG1110 COG1110, Reverse gyrase DNA replication, recombination, and repair 146303691 Common - Alpha-glucosidase Msed_0911 82 COG1501 COG1501, Alpha-glucosidases, family 31 of glycosyl hydrolases Carbohydrate transport and metabolism 146304254 Nonpathogen - hypothetical protein Msed_1489 4 None None None 146303064 Common - methylisocitrate lyase Msed_0279 136 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 146304928 Common - Threonyl/alanyl tRNA synthetase, SAD Msed_2181 225 COG2872 COG2872, Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain General function prediction only 146304815 Common - protein of unknown function DUF81 Msed_2067 43 COG0730 COG0730, Predicted permeases General function prediction only 146303030 Nonpathogen - MazG nucleotide pyrophosphohydrolase Msed_0245 15 COG1694 MazG, Predicted pyrophosphatase General function prediction only 146304284 Nonpathogen - hypothetical protein Msed_1520 7 None None None 146304470 Nonpathogen - hypothetical protein Msed_1707 6 None None None 146304457 Common - phosphoenolpyruvate synthase Msed_1694 236 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 146302912 Nonpathogen - hypothetical protein Msed_0127 2 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 146304397 Common rpl11p 50S ribosomal protein L11P Msed_1634 247 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 146303897 Common - 5-oxoprolinase (ATP-hydrolyzing) Msed_1127 118 COG0145 HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 146304348 Common - threonyl-tRNA synthetase Msed_1585 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146303454 Common - molybdenum cofactor synthesis domain Msed_0671 197 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 146303180 Common - peptidase S9, prolyl oligopeptidase active site domain protein Msed_0395 105 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 146304807 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Msed_2059 124 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 146303131 Nonpathogen - hypothetical protein Msed_0346 3 None None None 146304680 Nonpathogen - hypothetical protein Msed_1932 5 None None None 146303039 Nonpathogen - major facilitator superfamily MFS_1 Msed_0254 6 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 146302823 Common rps12P 30S ribosomal protein S12P Msed_0038 240 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 146304530 Nonpathogen - hypothetical protein Msed_1767 1 None None None 146304294 Common - ABC transporter related Msed_1530 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 146302995 Common - AAA family ATPase, CDC48 subfamily Msed_0210 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 146303783 Common - short-chain dehydrogenase/reductase SDR Msed_1007 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 146303144 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Msed_0359 230 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 146304710 Nonpathogen - hypothetical protein Msed_1962 2 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 146303664 Common - urease accessory protein UreG Msed_0884 145 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 146303051 Nonpathogen - zinc finger, CDGSH-type domain protein Msed_0266 7 COG3369 COG3369, Uncharacterized conserved protein Function unknown 146303260 Nonpathogen - hypothetical protein Msed_0475 2 None None None 146303219 Common - NAD-dependent epimerase/dehydratase Msed_0434 7 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 146303237 Common - aldo/keto reductase Msed_0452 203 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 146302894 Nonpathogen rpl19e 50S ribosomal protein L19e Msed_0109 33 COG2147 RPL19A, Ribosomal protein L19E Translation, ribosomal structure and biogenesis 146305036 Common - geranylgeranylglyceryl phosphate synthase-like protein Msed_2291 41 COG1646 COG1646, Predicted phosphate-binding enzymes, TIM-barrel fold General function prediction only 146304008 Nonpathogen - Hemerythrin HHE cation binding domain protein Msed_1239 2 COG5592 COG5592, Uncharacterized conserved protein Function unknown 146302939 Common - AMMECR1 domain protein Msed_0154 73 COG2078 AMMECR1, Uncharacterized conserved protein Function unknown 146304290 Nonpathogen - phosphohydrolase (DHH superfamily)-like protein Msed_1526 12 COG2404 COG2404, Predicted phosphohydrolase (DHH superfamily) General function prediction only 146304417 Nonpathogen - hypothetical protein Msed_1654 2 None None None 146304526 Common pyrH uridylate kinase Msed_1763 232 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 146304213 Common - phosphoribosylaminoimidazole carboxylase, catalytic subunit Msed_1448 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 146303408 Nonpathogen - hypothetical protein Msed_0625 2 None None None 146304336 Nonpathogen - hypothetical protein Msed_1573 3 COG3432 COG3432, Predicted transcriptional regulator Transcription 146304480 Nonpathogen - hypothetical protein Msed_1717 4 COG2522 COG2522, Predicted transcriptional regulator General function prediction only 146304865 Nonpathogen - hypothetical protein Msed_2118 4 None None None 146303861 Nonpathogen - hypothetical protein Msed_1089 3 None None None 146304144 Common - DEAD/DEAH box helicase domain protein Msed_1378 200 COG1204 COG1204, Superfamily II helicase General function prediction only 146303081 Common - Rubrerythrin Msed_0296 80 COG1592 COG1592, Rubrerythrin Energy production and conversion 146304441 Nonpathogen - hypothetical protein Msed_1678 6 None None None 146302946 Nonpathogen - hypothetical protein Msed_0161 1 None None None 146304204 Nonpathogen - Cupin 2, conserved barrel domain protein Msed_1439 7 COG4309 COG4309, Uncharacterized conserved protein Function unknown 146303091 Common - pyruvate/ketoisovalerate oxidoreductase, gamma subunit Msed_0306 78 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 146303221 Common - D-lactate dehydrogenase (cytochrome) Msed_0436 201 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 146304263 Nonpathogen - hypothetical protein Msed_1498 2 None None None 146304375 Common - glutamine synthetase, type I Msed_1612 227 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 146303427 Common - carbon monoxide dehydrogenase subunit G Msed_0644 39 COG3427 COG3427, Uncharacterized conserved protein Function unknown 146304550 Nonpathogen - hypothetical protein Msed_1787 25 COG1931 COG1931, Uncharacterized protein conserved in archaea Function unknown 146303659 Common - protein of unknown function DUF404 Msed_0879 89 COG2308 COG2308, Uncharacterized conserved protein Function unknown 146304014 Nonpathogen - hypothetical protein Msed_1246 2 None None None 146305028 Nonpathogen - hypothetical protein Msed_2282 5 COG4342 COG4342, Uncharacterized protein conserved in archaea Function unknown 146303772 Common - 4-hydroxyphenylacetate 3-hydroxylase Msed_0996 50 COG2368 COG2368, Aromatic ring hydroxylase Secondary metabolites biosynthesis, transport, and catabolism 146303058 Common - thioesterase superfamily protein Msed_0273 61 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 146303404 Nonpathogen - CopG domain protein DNA-binding domain protein Msed_0621 5 None None None 146303677 Nonpathogen - protein of unknown function DUF504 Msed_0897 2 COG1531 COG1531, Uncharacterized protein conserved in archaea Function unknown 146304798 Common rfc replication factor C small subunit Msed_2050 249 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 146303834 Common - hypothetical protein Msed_1061 5 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 146304366 Common - D-fructose-6-phosphate amidotransferase Msed_1603 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 146304090 Nonpathogen - flagella assembly protein J-like protein Msed_1324 18 COG1955 FlaJ, Archaeal flagella assembly protein J Cell motility and secretion / Intracellular trafficking and secretion 146303151 Nonpathogen - hypothetical protein Msed_0366 4 None None None 146303745 Common - selenium-binding protein Msed_0967 18 None None None 146304592 Common - polysaccharide biosynthesis protein Msed_1835 25 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 146304755 Common - peptidase U62, modulator of DNA gyrase Msed_2007 115 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 146303139 Common - SirA family protein Msed_0354 6 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 146303332 Common - protein of unknown function DUF81 Msed_0549 44 COG0730 COG0730, Predicted permeases General function prediction only 146303468 Common - peptidase T2, asparaginase 2 Msed_0685 84 COG1446 COG1446, Asparaginase Amino acid transport and metabolism 146303796 Nonpathogen - hypothetical protein Msed_1020 1 None None None 146303390 Nonpathogen - hypothetical protein Msed_0607 2 None None None 146304410 Common - Acetyl-CoA acetyltransferase-like protein Msed_1647 91 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 146304055 Common - binding-protein-dependent transport systems inner membrane component Msed_1288 151 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 146304220 Common - amino acid permease-associated region Msed_1455 175 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146303171 Common - acetyl-CoA acetyltransferase Msed_0386 126 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 146303884 Common - succinate dehydrogenase, cytochrome b subunit Msed_1113 12 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 146304701 Common - Radical SAM domain protein Msed_1953 32 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 146304495 Nonpathogen - H/ACA RNA-protein complex component Gar1 Msed_1732 2 COG3277 GAR1, RNA-binding protein involved in rRNA processing Translation, ribosomal structure and biogenesis 146303551 Common - Inosine/uridine-preferring nucleoside hydrolase Msed_0768 84 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 146303817 Nonpathogen - DNA polymerase, beta domain protein region Msed_1044 9 COG1708 COG1708, Predicted nucleotidyltransferases General function prediction only 146303605 Nonpathogen - band 7 protein Msed_0822 6 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 146304571 Common - NAD-dependent epimerase/dehydratase Msed_1809 232 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 146303652 Common - protein of unknown function DUF488 Msed_0871 77 COG3189 COG3189, Uncharacterized conserved protein Function unknown 146304067 Common - Alcohol dehydrogenase GroES domain protein Msed_1301 186 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 146304003 Nonpathogen - hypothetical protein Msed_1234 3 None None None 146304626 Common - Transketolase, central region Msed_1878 230 COG3958 COG3958, Transketolase, C-terminal subunit Carbohydrate transport and metabolism 146303847 Common - Squalene/phytoene synthase Msed_1075 102 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 146303318 Nonpathogen - hypothetical protein Msed_0535 2 None None None 146304176 Nonpathogen - transcriptional regulator-like protein Msed_1410 18 COG2522 COG2522, Predicted transcriptional regulator General function prediction only 146304543 Common - ABC-type molybdate transport system periplasmic component-like protein Msed_1780 27 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 146303438 Nonpathogen - translation initiation factor IF-1A Msed_0655 34 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 146304789 Nonpathogen - hypothetical protein Msed_2041 2 None None None 146302928 Common - phage integrase family protein Msed_0143 7 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 146302893 Nonpathogen rpl32e 50S ribosomal protein L32e Msed_0108 21 COG1717 RPL32, Ribosomal protein L32E Translation, ribosomal structure and biogenesis 146303962 Nonpathogen - hypothetical protein Msed_1193 1 COG4386 COG4386, Mu-like prophage tail sheath protein gpL General function prediction only 146302815 Common - translation initiation factor IF-2 Msed_0030 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 146303939 Nonpathogen - CRISPR-associated protein Cas6 Msed_1170 19 COG1583 COG1583, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 146303707 Nonpathogen - hypothetical protein Msed_0927 1 None None None 146304152 Nonpathogen - hypothetical protein Msed_1386 2 None None None 146303534 Nonpathogen - hypothetical protein Msed_0751 2 None None None 146302800 Common - adenylosuccinate synthetase Msed_0015 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 146303443 Nonpathogen - NMD3 Msed_0660 27 COG1499 NMD3, NMD protein affecting ribosome stability and mRNA decay Translation, ribosomal structure and biogenesis 146303932 Nonpathogen - hypothetical protein Msed_1163 3 COG1353 COG1353, Predicted hydrolase of the HD superfamily (permuted catalytic motifs) General function prediction only 146302871 Nonpathogen - aminopeptidase Iap family-like protein Msed_0086 2 COG4882 COG4882, Predicted aminopeptidase, Iap family General function prediction only 146303230 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Msed_0445 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 146303795 Nonpathogen - hypothetical protein Msed_1019 1 None None None 146303582 Nonpathogen - hypothetical protein Msed_0799 2 None None None 146304112 Common - major facilitator superfamily MFS_1 Msed_1346 116 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 146304191 Common - putative signal-transduction protein with CBS domains Msed_1425 161 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 146302932 Common - Carbamoyl-phosphate synthase L chain, ATP-binding Msed_0147 234 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 146303353 Common - Cytochrome-c oxidase Msed_0570 174 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 146304847 Common - Precorrin isomerase-like protein Msed_2099 106 COG2082 CobH, Precorrin isomerase Coenzyme metabolism 146303547 Nonpathogen - Methyltransferase type 11 Msed_0764 23 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 146304276 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Msed_1511 57 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 146303525 Nonpathogen - hypothetical protein Msed_0742 2 None None None 146303431 Common - Inorganic diphosphatase Msed_0648 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 146302905 Nonpathogen - hypothetical protein Msed_0120 6 None None None 146303078 Nonpathogen - hypothetical protein Msed_0293 4 None None None 146304289 Common - putative peroxiredoxin Msed_1525 220 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 146303911 Nonpathogen - CRISPR-associated protein Cas5 family Msed_1142 7 COG1688 COG1688, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 146303850 Common - GCN5-related N-acetyltransferase Msed_1078 18 COG3393 COG3393, Predicted acetyltransferase General function prediction only 146303616 Common - protein kinase Msed_0833 111 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 146304487 Nonpathogen - hypothetical protein Msed_1724 5 COG2083 COG2083, Uncharacterized protein conserved in archaea Function unknown 146303493 Nonpathogen - hypothetical protein Msed_0710 4 None None None 146304127 Nonpathogen - hypothetical protein Msed_1361 2 COG5440 COG5440, Uncharacterized conserved protein Function unknown 146303923 Nonpathogen - CRISPR-associated protein, MJ1666 family Msed_1154 8 COG1517 COG1517, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 146304160 Nonpathogen - hypothetical protein Msed_1394 4 None None None 146302829 Nonpathogen - hypothetical protein Msed_0044 8 COG4920 COG4920, Predicted membrane protein Function unknown 146303793 Common - UspA domain protein Msed_1017 158 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 146304894 Nonpathogen rps4p 30S ribosomal protein S4 Msed_2147 37 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 146303191 Common - AMP-dependent synthetase and ligase Msed_0406 221 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 146303674 Common - SirA family protein Msed_0894 20 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 146304188 Common - Coenzyme F390 synthetase-like protein Msed_1422 103 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 146303636 Nonpathogen - Methyltransferase type 11 Msed_0855 11 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 146304985 Nonpathogen - protein of unknown function DUF359 Msed_2239 28 COG1909 COG1909, Uncharacterized protein conserved in archaea Function unknown 146304113 Nonpathogen - DNA polymerase, beta domain protein region Msed_1347 4 COG1708 COG1708, Predicted nucleotidyltransferases General function prediction only 146302968 Common - glycosyl transferase, family 2 Msed_0183 200 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 146302945 Nonpathogen - hypothetical protein Msed_0160 2 None None None 146303562 Common - periplasmic solute-binding protein-like protein Msed_0779 22 COG2107 COG2107, Predicted periplasmic solute-binding protein General function prediction only 146304396 Nonpathogen nusG transcription antitermination protein NusG Msed_1633 35 COG0250 NusG, Transcription antiterminator Transcription 146304031 Common - Rieske (2Fe-2S) domain protein Msed_1263 10 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 146304961 Nonpathogen - hypothetical protein Msed_2215 2 None None None 146303511 Common - peptidase M61 domain protein Msed_0728 55 COG3975 COG3975, Predicted protease with the C-terminal PDZ domain General function prediction only 146304414 Nonpathogen - UspA domain protein Msed_1651 9 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 146304422 Nonpathogen - SpoVT/AbrB domain protein Msed_1659 25 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 146304574 Nonpathogen - hypothetical protein Msed_1812 2 None None None 146304243 Nonpathogen - hypothetical protein Msed_1478 2 None None None 146302838 Common - hypothetical protein Msed_0053 32 COG0433 COG0433, Predicted ATPase General function prediction only 146303218 Nonpathogen - hypothetical protein Msed_0433 1 None None None 146303993 Common - AMP-dependent synthetase and ligase Msed_1224 226 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 146303370 Nonpathogen - hypothetical protein Msed_0587 1 None None None 146303361 Nonpathogen - hypothetical protein Msed_0578 4 None None None 146304794 Nonpathogen cdc6 cell division control protein 6 Msed_2046 31 COG1474 CDC6, Cdc6-related protein, AAA superfamily ATPase DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones 146305020 Nonpathogen - PUA domain containing protein Msed_2274 30 COG1370 COG1370, Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit Posttranslational modification, protein turnover, chaperones 146303257 Nonpathogen - hypothetical protein Msed_0472 1 None None None 146303281 Common - putative agmatinase Msed_0497 150 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 146304320 Nonpathogen - hypothetical protein Msed_1557 4 None None None 146304904 Common - Radical SAM domain protein Msed_2157 30 COG2108 COG2108, Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme General function prediction only 146303571 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase Msed_0788 159 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 146303764 Nonpathogen - hypothetical protein Msed_0988 4 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 146303592 Nonpathogen - hypothetical protein Msed_0809 2 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 146303324 Nonpathogen - hypothetical protein Msed_0541 4 COG1665 COG1665, Uncharacterized protein conserved in archaea Function unknown 146302855 Nonpathogen - 50S ribosomal protein L15e Msed_0070 34 COG1632 RPL15A, Ribosomal protein L15E Translation, ribosomal structure and biogenesis 146303722 Nonpathogen - hypothetical protein Msed_0942 1 None None None 146304357 Common - ATP--cobalamin adenosyltransferase Msed_1594 131 COG2096 COG2096, Uncharacterized conserved protein Function unknown 146304350 Nonpathogen - hypothetical protein Msed_1587 1 None None None 146303845 Common - Phytoene dehydrogenase-related protein Msed_1073 81 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 146304504 Common - CutA1 divalent ion tolerance protein Msed_1741 119 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 146303240 Common - Lactate/malate dehydrogenase Msed_0455 167 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 146303752 Common - major facilitator superfamily MFS_1 Msed_0975 27 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146304222 Common - formate dehydrogenase, alpha subunit Msed_1457 195 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 146303383 Common - RNA 3'-terminal-phosphate cyclase Msed_0600 47 COG0430 RCL1, RNA 3'-terminal phosphate cyclase RNA processing and modification 146303466 Nonpathogen - hypothetical protein Msed_0683 2 None None None 146304169 Common - putative endoribonuclease L-PSP Msed_1403 175 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 146304968 Nonpathogen rps24e 30S ribosomal protein S24e Msed_2222 20 COG2004 RPS24A, Ribosomal protein S24E Translation, ribosomal structure and biogenesis 146304884 Common - aspartate/glutamate/uridylate kinase Msed_2137 36 COG1608 COG1608, Predicted archaeal kinase General function prediction only 146303552 Common - SMC domain protein Msed_0769 83 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 146304046 Common - transcriptional regulator, MarR family Msed_1279 147 COG1846 MarR, Transcriptional regulators Transcription 146304877 Common - SPP-like hydrolase Msed_2130 66 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 146304754 Common - peptidase U62, modulator of DNA gyrase Msed_2006 166 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 146304478 Common argS arginyl-tRNA synthetase Msed_1715 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146304682 Nonpathogen - hypothetical protein Msed_1934 3 None None None 146302831 Common - 3,4-dihydroxy-2-butanone 4-phosphate synthase Msed_0046 219 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 146304723 Common - small GTP-binding protein Msed_1975 246 COG1084 COG1084, Predicted GTPase General function prediction only 146304515 Common - protein of unknown function UPF0027 Msed_1752 121 COG1690 RtcB, Uncharacterized conserved protein Function unknown 146304565 Nonpathogen - ribosomal protein S27E Msed_1803 34 COG2051 RPS27A, Ribosomal protein S27E Translation, ribosomal structure and biogenesis 146303873 Common - hypothetical protein Msed_1101 116 COG2110 COG2110, Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 General function prediction only 146303005 Nonpathogen - type I phosphodiesterase/nucleotide pyrophosphatase Msed_0220 17 COG3379 COG3379, Uncharacterized conserved protein Function unknown 146303705 Nonpathogen - hypothetical protein Msed_0925 1 None None None 146304695 Common - Histidinol dehydrogenase Msed_1947 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 146303115 Nonpathogen - hypothetical protein Msed_0330 3 None None None 146304637 Common - Superoxide dismutase Msed_1889 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 146304497 Nonpathogen - phosphoesterase, putative Msed_1734 34 COG1407 COG1407, Predicted ICC-like phosphoesterases General function prediction only 146303090 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Msed_0305 166 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 146303645 Nonpathogen - PilT protein domain protein Msed_0864 4 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 146304087 Common - Vinylacetyl-CoA Delta-isomerase Msed_1321 50 COG2368 COG2368, Aromatic ring hydroxylase Secondary metabolites biosynthesis, transport, and catabolism 146304206 Nonpathogen - hypothetical protein Msed_1441 2 None None None 146302795 Common - histidine triad (HIT) protein Msed_0010 120 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 146304106 Nonpathogen - hypothetical protein Msed_1340 1 None None None 146303163 Nonpathogen - hypothetical protein Msed_0378 2 None None None 146303742 Common sat sulfate adenylyltransferase Msed_0963 63 COG2046 MET3, ATP sulfurylase (sulfate adenylyltransferase) Inorganic ion transport and metabolism 146304978 Nonpathogen - putative transcriptional regulator, CopG/Arc/MetJ family Msed_2232 8 COG3609 COG3609, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain Transcription 146303689 Nonpathogen - hypothetical protein Msed_0909 2 None None None 146304973 Common - aldo/keto reductase Msed_2227 203 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 146303455 Common - homoserine kinase Msed_0672 107 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 146303307 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit beta Msed_0524 108 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 146302927 Nonpathogen - hypothetical protein Msed_0142 1 None None None 146303976 Nonpathogen - hypothetical protein Msed_1207 3 None None None 146304676 Nonpathogen - hypothetical protein Msed_1928 2 COG3978 COG3978, Acetolactate synthase (isozyme II), small (regulatory) subunit Function unknown 146304583 Common - FAD linked oxidase domain protein Msed_1821 76 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 146303502 Common - Methyltransferase type 11 Msed_0719 67 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 146303966 Common - type II secretion system protein E Msed_1197 211 COG0630 VirB11, Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis Cell motility and secretion / Intracellular trafficking and secretion 146303008 Common - phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I Msed_0223 243 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 146303238 Common - hypothetical protein Msed_0453 7 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146304092 Nonpathogen - flagellar accessory protein FlaH Msed_1326 21 COG2874 FlaH, Predicted ATPases involved in biogenesis of archaeal flagella Cell motility and secretion / Intracellular trafficking and secretion 146304432 Nonpathogen - hypothetical protein Msed_1669 2 None None None 146304054 Common - binding-protein-dependent transport systems inner membrane component Msed_1287 141 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 146302919 Common - DEAD_2 domain protein Msed_0134 26 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 146304223 Common - Aldose 1-epimerase Msed_1458 56 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 146304625 Common - chorismate mutase Msed_1877 55 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 146303012 Common - Orotidine 5'-phosphate decarboxylase Msed_0227 57 COG0269 SgbH, 3-hexulose-6-phosphate synthase and related proteins Carbohydrate transport and metabolism 146303025 Common - Nucleotidyl transferase Msed_0240 206 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 146303613 Common - 3-isopropylmalate dehydratase large subunit Msed_0830 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 146303125 Nonpathogen - Dipeptidyl aminopeptidase/acylaminoacyl-peptidase-like protein Msed_0340 5 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 146303604 Nonpathogen - hypothetical protein Msed_0821 7 None None None 146302860 Nonpathogen - Shwachman-Bodian-Diamond syndrome protein Msed_0075 34 COG1500 COG1500, Predicted exosome subunit Translation, ribosomal structure and biogenesis 146304778 Nonpathogen - hypothetical protein Msed_2030 2 None None None 146303981 Common - Transketolase, central region Msed_1212 199 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 146304855 Common - Precorrin-6B methylase 2-like protein Msed_2108 85 COG2242 CobL, Precorrin-6B methylase 2 Coenzyme metabolism 146303152 Common - aldehyde dehydrogenase Msed_0367 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 146305015 Common - eIF-2B alpha/beta/delta-related uncharacterized protein Msed_2269 132 COG0182 COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 146305029 Nonpathogen - hypothetical protein Msed_2283 2 None None None 146302974 Common - peptidase M24 Msed_0189 247 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 146303482 Common - protein of unknown function UPF0131 Msed_0699 24 COG2105 COG2105, Uncharacterized conserved protein Function unknown 146304544 Common - binding-protein-dependent transport systems inner membrane component Msed_1781 202 COG0555 CysU, ABC-type sulfate transport system, permease component Posttranslational modification, protein turnover, chaperones 146303734 Common - AIR synthase related protein domain protein Msed_0955 106 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 146303175 Nonpathogen - carbonic anhydrase Msed_0390 5 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 146304342 Nonpathogen - hypothetical protein Msed_1579 1 None None None 146304305 Common - CoB--CoM heterodisulfide reductase Msed_1542 54 COG2048 HdrB, Heterodisulfide reductase, subunit B Energy production and conversion 146303835 Common - iron-containing alcohol dehydrogenase Msed_1062 131 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 146303231 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Msed_0446 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 146303350 Common - ABC-2 type transporter Msed_0567 11 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 146303363 Nonpathogen - hypothetical protein Msed_0580 2 None None None 146302808 Common - phosphoribosyltransferase Msed_0023 91 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 146304741 Common - 3-hydroxyacyl-CoA dehydrogenase, NAD-binding Msed_1993 159 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 146302787 Nonpathogen - protein of unknown function DUF99 Msed_0002 10 COG1628 COG1628, Uncharacterized conserved protein Function unknown 146303630 Common - ABC transporter related Msed_0848 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 146304620 Nonpathogen - shikimate kinase Msed_1872 27 COG1685 COG1685, Archaeal shikimate kinase Amino acid transport and metabolism / Coenzyme metabolism 146304079 Nonpathogen - hypothetical protein Msed_1313 4 None None None 146304593 Common - glycosyl transferase, group 1 Msed_1842 66 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 146303671 Common - major facilitator superfamily MFS_1 Msed_0891 194 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146303498 Common - transcriptional regulator, PadR-like family Msed_0715 4 COG1695 COG1695, Predicted transcriptional regulators Transcription 146304085 Nonpathogen - protein of unknown function DUF1641 Msed_1319 3 COG2427 COG2427, Uncharacterized conserved protein Function unknown 146303149 Nonpathogen - TQO small subunit DoxA domain protein Msed_0364 3 None None None 146302842 Common - PUA domain containing protein Msed_0057 144 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 146305038 Nonpathogen - putative transcriptional regulator, XRE family Msed_2293 35 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 146304240 Common - DSBA oxidoreductase Msed_1475 65 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 146303398 Common panB 3-methyl-2-oxobutanoate hydroxymethyltransferase Msed_0615 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 146303662 Common - molybdopterin oxidoreductase Msed_0882 190 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 146303852 Nonpathogen - glutamine amidotransferase-like protein Msed_1080 13 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 146303272 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Msed_0487 242 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 146304225 Nonpathogen - Thermopsin Msed_1460 6 None None None 146302873 Common - isopropylmalate/isohomocitrate dehydrogenase Msed_0088 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 146302816 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) Msed_0031 202 COG0281 SfcA, Malic enzyme Energy production and conversion 146302818 Common - DNA-directed RNA polymerase subunit beta Msed_0033 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 146303300 Common - Uncharacterized flavoprotein-like protein Msed_0517 38 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 146304493 Nonpathogen - protein of unknown function DUF373 Msed_1730 29 COG2237 COG2237, Predicted membrane protein Function unknown 146303741 Common - phosphoadenosine phosphosulfate reductase Msed_0962 162 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 146302849 Common ksgA dimethyladenosine transferase Msed_0064 201 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 146303938 Common - Uncharacterized protein predicted to be involved in DNA repair-like protein Msed_1169 34 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 146303687 Common - major facilitator superfamily MFS_1 Msed_0907 225 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146304537 Common - aldehyde dehydrogenase Msed_1774 224 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 146304923 Common - Lysine exporter protein (LYSE/YGGA) Msed_2176 20 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 146304650 Common - NADH dehydrogenase (quinone) Msed_1902 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 146303043 Nonpathogen - major facilitator superfamily MFS_1 Msed_0258 5 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146304125 Nonpathogen - major facilitator superfamily MFS_1 Msed_1359 15 None None None 146303418 Common - FAD dependent oxidoreductase Msed_0635 83 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 146304100 Nonpathogen - hypothetical protein Msed_1334 1 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146304443 Nonpathogen - hypothetical protein Msed_1680 2 None None None 146304760 Common - NADH-quinone oxidoreductase, B subunit Msed_2012 191 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 146304408 Common - S-adenosylmethionine decarboxylase proenzyme Msed_1645 67 COG1586 SpeD, S-adenosylmethionine decarboxylase Amino acid transport and metabolism 146303968 Common - thiamine pyrophosphate enzyme domain protein TPP-binding Msed_1199 97 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 146304942 Nonpathogen - hypothetical protein Msed_2195 2 None None None 146304068 Common - Radical SAM domain protein Msed_1302 116 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 146304641 Nonpathogen - hypothetical protein Msed_1893 2 COG4847 COG4847, Uncharacterized protein conserved in archaea Function unknown 146304845 Nonpathogen - hypothetical protein Msed_2097 3 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 146303150 Nonpathogen - hypothetical protein Msed_0365 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 146303339 Common - Cobyrinic acid a,c-diamide synthase Msed_0556 212 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146303223 Common - Alcohol dehydrogenase GroES domain protein Msed_0438 200 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 146303206 Nonpathogen - hypothetical protein Msed_0421 1 None None None 146304313 Common - DsrE family protein Msed_1550 5 COG2044 COG2044, Predicted peroxiredoxins General function prediction only 146304370 Common - Pyridoxal-5'-phosphate-dependent enzyme, beta subunit Msed_1607 226 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 146303788 Common - peptidase M48, Ste24p Msed_1012 181 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 146304771 Common - MoeA domain protein, domain I and II Msed_2023 194 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 146304174 Nonpathogen - hypothetical protein Msed_1408 2 None None None 146303265 Common - cytochrome c oxidase, subunit II Msed_0480 18 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 146304377 Common - thioredoxin Msed_1614 233 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 146303527 Nonpathogen - protein of unknown function Met10 Msed_0744 33 COG2520 COG2520, Predicted methyltransferase General function prediction only 146303056 Common - acetyl-CoA acetyltransferase Msed_0271 84 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 146304549 Nonpathogen - Dephospho-CoA kinase-like protein Msed_1786 28 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 146303716 Nonpathogen - hypothetical protein Msed_0936 6 COG3391 COG3391, Uncharacterized conserved protein Function unknown 146304261 Common - Na+/solute symporter Msed_1496 35 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 146302874 Common ileS isoleucyl-tRNA synthetase Msed_0089 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146303099 Nonpathogen - hypothetical protein Msed_0314 2 None None None 146303520 Common - aminotransferase, class V Msed_0737 240 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 146304532 Nonpathogen - hypothetical protein Msed_1769 1 None None None 146304707 Nonpathogen - hypothetical protein Msed_1959 2 None None None 146303774 Nonpathogen - HEPN domain protein Msed_0998 4 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 146304155 Nonpathogen - Zn-dependent protease-like protein Msed_1389 28 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 146303804 Common - hypothetical protein Msed_1031 21 None None None 146304806 Common - hydrolase or acyltransferase (alpha/beta hydrolase superfamily)-like protein Msed_2058 38 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 146303473 Nonpathogen - hypothetical protein Msed_0690 2 None None None 146304287 Common - protein of unknown function DUF763 Msed_1523 32 COG1415 COG1415, Uncharacterized conserved protein Function unknown 146303269 Common - cytochrome c oxidase, subunit I Msed_0484 170 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 146303449 Nonpathogen - hypothetical protein Msed_0666 5 None None None 146302926 Nonpathogen - hypothetical protein Msed_0141 1 None None None 146303228 Common - binding-protein-dependent transport systems inner membrane component Msed_0443 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 146304339 Common - diphosphomevalonate decarboxylase Msed_1576 29 COG3407 MVD1, Mevalonate pyrophosphate decarboxylase Lipid metabolism 146303212 Nonpathogen - hypothetical protein Msed_0427 4 None None None 146304398 Common rpl1P 50S ribosomal protein L1P Msed_1635 126 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 146304154 Common - protein of unknown function UPF0066 Msed_1388 98 COG1720 COG1720, Uncharacterized conserved protein Function unknown 146303145 Nonpathogen - hypothetical protein Msed_0360 2 None None None 146304314 Common - pyridine nucleotide-disulphide oxidoreductase dimerisation region Msed_1551 245 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 146304839 Common - cobalamin (vitamin B12) biosynthesis CbiG protein Msed_2091 61 COG2073 CbiG, Cobalamin biosynthesis protein CbiG Coenzyme metabolism 146302896 Common rps5p 30S ribosomal protein S5P Msed_0111 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 146304329 Nonpathogen - transcriptional regulator, TrmB Msed_1566 4 COG3355 COG3355, Predicted transcriptional regulator Transcription 146304761 Common - Hydroxypyruvate reductase Msed_2013 86 COG2379 GckA, Putative glycerate kinase Carbohydrate transport and metabolism 146305005 Common - protein of unknown function DUF100 Msed_2259 38 COG1980 COG1980, Archaeal fructose 1,6-bisphosphatase Carbohydrate transport and metabolism 146303409 Nonpathogen - hypothetical protein Msed_0626 2 None None None 146304567 Nonpathogen - Oligosaccharyl transferase, STT3 subunit Msed_1805 13 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 146304482 Common - glutamyl-tRNA(Gln) amidotransferase subunit E Msed_1719 192 COG2511 GatE, Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain) Translation, ribosomal structure and biogenesis 146304419 Common - SufBD protein Msed_1656 163 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 146303357 Nonpathogen - hypothetical protein Msed_0574 2 None None None 146302907 Nonpathogen - hypothetical protein Msed_0122 1 None None None 146303424 Nonpathogen - ZPR1-related zinc finger protein Msed_0641 29 COG1779 COG1779, C4-type Zn-finger protein General function prediction only 146304001 Nonpathogen - hypothetical protein Msed_1232 1 None None None 146303293 Common - 2-ketoisovalerate ferredoxin oxidoreductase subunit beta Msed_0510 122 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 146303684 Nonpathogen - hypothetical protein Msed_0904 1 None None None 146304391 Nonpathogen - translation initiation factor IF-6 Msed_1628 33 COG1976 TIF6, Translation initiation factor 6 (eIF-6) Translation, ribosomal structure and biogenesis 146304660 Nonpathogen - DNA primase large subunit Msed_1912 6 COG2219 PRI2, Eukaryotic-type DNA primase, large subunit DNA replication, recombination, and repair 146303491 Nonpathogen - hypothetical protein Msed_0708 2 None None None 146303569 Nonpathogen - hypothetical protein Msed_0786 2 None None None 146302981 Common - Alcohol dehydrogenase GroES domain protein Msed_0196 208 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 146304700 Common - seryl-tRNA synthetase Msed_1952 244 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 146304867 Common - putative transcriptional regulator, GntR family Msed_2120 233 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 146303242 Common - major facilitator superfamily MFS_1 Msed_0457 129 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146304966 Nonpathogen - hypothetical protein Msed_2220 3 None None None 146304489 Nonpathogen - N(2),N(2)-dimethylguanosine tRNA methyltransferase Msed_1726 38 COG1867 TRM1, N2,N2-dimethylguanosine tRNA methyltransferase Translation, ribosomal structure and biogenesis 146304818 Common - major facilitator superfamily MFS_1 Msed_2070 215 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146304006 Common - hypothetical protein Msed_1237 112 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 146303690 Common - Methyltransferase type 11 Msed_0910 58 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 146303084 Common - molybdopterin dehydrogenase, FAD-binding Msed_0299 97 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 146302886 Common rpl14p 50S ribosomal protein L14P Msed_0101 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 146304140 Common - DEAD/DEAH box helicase domain protein Msed_1374 133 COG1204 COG1204, Superfamily II helicase General function prediction only 146303618 Nonpathogen - hypothetical protein Msed_0835 2 None None None 146303497 Nonpathogen - hypothetical protein Msed_0714 1 None None None 146302988 Nonpathogen rpl40e 50S ribosomal protein L40e Msed_0203 18 COG1552 RPL40A, Ribosomal protein L40E Translation, ribosomal structure and biogenesis 146303983 Nonpathogen - PilT protein domain protein Msed_1214 3 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 146303123 Nonpathogen - hypothetical protein Msed_0338 4 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 146304233 Nonpathogen - transcriptional regulator, AbrB family Msed_1468 4 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 146304138 Nonpathogen - Dinitrogenase iron-molybdenum cofactor biosynthesis protein Msed_1372 4 COG1433 COG1433, Uncharacterized conserved protein Function unknown 146304528 Common - 2-isopropylmalate synthase Msed_1765 223 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 146303809 Common ubiA prenyltransferase Msed_1036 94 COG1575 MenA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase Coenzyme metabolism 146304690 Common - histidinol-phosphate aminotransferase Msed_1942 229 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 146303178 Nonpathogen - hypothetical protein Msed_0393 3 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 146304363 Common - beta-lactamase domain protein Msed_1600 158 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 146303549 Common - putative signal transduction protein with CBS domains Msed_0766 180 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 146303259 Nonpathogen - hypothetical protein Msed_0474 2 None None None 146304551 Common - ribonuclease Z Msed_1788 110 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 146303069 Nonpathogen - hypothetical protein Msed_0284 2 None None None 146304302 Common - ammonium transporter Msed_1539 201 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 146303848 Common - hypothetical protein Msed_1076 5 None None None 146304987 Common - DNA-directed RNA polymerase subunit E' Msed_2241 98 COG1095 RPB7, DNA-directed RNA polymerase, subunit E' Transcription 146304278 Common - transposase, IS605 OrfB family Msed_1513 78 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 146304657 Common - hypothetical protein Msed_1909 51 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 146303879 Common - oxidoreductase, molybdopterin binding Msed_1107 125 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 146304230 Common - protein of unknown function DUF224, cysteine-rich region domain protein Msed_1465 33 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 146302913 Nonpathogen - hypothetical protein Msed_0128 8 None None None 146304024 Nonpathogen - hypothetical protein Msed_1256 3 COG3473 COG3473, Maleate cis-trans isomerase Secondary metabolites biosynthesis, transport, and catabolism 146304198 Nonpathogen - Hydrogenase 4 membrane component (E)-like protein Msed_1433 10 COG4237 HyfE, Hydrogenase 4 membrane component (E) Energy production and conversion 146303886 Common - hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit Msed_1115 148 COG1838 FumA, Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain Energy production and conversion 146304268 Nonpathogen - amino acid permease-associated region Msed_1503 8 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 146303819 Common - extracellular solute-binding protein, family 5 Msed_1046 126 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 146303751 Common - hypothetical protein Msed_0974 16 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 146303032 Nonpathogen - hypothetical protein Msed_0247 4 None None None 146304282 Nonpathogen - hypothetical protein Msed_1518 1 None None None 146304412 Common - 3-hydroxy-3-methylglutaryl Coenzyme A reductase Msed_1649 60 COG1257 HMG1, Hydroxymethylglutaryl-CoA reductase Lipid metabolism 146304737 Common - carbamoyl phosphate synthase small subunit Msed_1989 233 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 146303028 Common - Gamma-glutamyltransferase Msed_0243 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 146304730 Common - Amidophosphoribosyltransferase Msed_1982 231 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 146303554 Common - putative signal-transduction protein with CBS domains Msed_0771 197 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 146303071 Nonpathogen - hypothetical protein Msed_0286 2 None None None 146303101 Nonpathogen - hypothetical protein Msed_0316 2 None None None 146303054 Common - protein of unknown function DUF35 Msed_0269 14 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 146303820 Common - binding-protein-dependent transport systems inner membrane component Msed_1047 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 146303420 Common - phosphoribosyltransferase Msed_0637 125 COG2236 COG2236, Predicted phosphoribosyltransferases General function prediction only 146303541 Common - carbohydrate kinase, YjeF related protein Msed_0758 221 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 146303017 Common - protein of unknown function DUF460 Msed_0232 31 COG2433 COG2433, Uncharacterized conserved protein Function unknown 146304021 Common - major facilitator superfamily MFS_1 Msed_1253 172 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 146304361 Nonpathogen - helix-turn-helix domain protein Msed_1598 29 COG1709 COG1709, Predicted transcriptional regulator Transcription 146304514 Nonpathogen - hypothetical protein Msed_1751 6 None None None 146302961 Nonpathogen - transcriptional regulator, AbrB family Msed_0176 1 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 146303833 Common - transcriptional regulator, GntR family Msed_1060 134 COG1802 GntR, Transcriptional regulators Transcription 146304473 Common - thermosome Msed_1710 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 146304563 Nonpathogen - Nucleolar RNA-binding protein Nop10p Msed_1801 19 COG2260 COG2260, Predicted Zn-ribbon RNA-binding protein Translation, ribosomal structure and biogenesis 146302990 Common aspC aspartyl-tRNA synthetase Msed_0205 249 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 146303941 Common - ATPase Msed_1172 15 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 146304684 Common - S-adenosylmethionine decarboxylase proenzyme Msed_1936 69 COG1586 SpeD, S-adenosylmethionine decarboxylase Amino acid transport and metabolism 146303432 Common - glycosyl transferase, family 2 Msed_0649 147 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 146303250 Common - Formamidase Msed_0465 66 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 146302958 Nonpathogen - hypothetical protein Msed_0173 5 COG1400 SEC65, Signal recognition particle 19 kDa protein Intracellular trafficking and secretion 146302798 Common - putative transcriptional regulator, AsnC family Msed_0013 50 COG1522 Lrp, Transcriptional regulators Transcription 146304285 Common - protein of unknown function DUF47 Msed_1521 10 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 146303803 Common - Methyltransferase type 12 Msed_1030 19 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 146303117 Common - electron transfer flavoprotein, alpha subunit Msed_0332 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 146304886 Common - protein of unknown function DUF52 Msed_2139 65 COG1355 COG1355, Predicted dioxygenase General function prediction only 146303598 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Msed_0815 160 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 146304627 Common - Transketolase domain protein Msed_1879 221 COG3959 COG3959, Transketolase, N-terminal subunit Carbohydrate transport and metabolism 146304902 Common - GCN5-related N-acetyltransferase Msed_2155 93 COG0456 RimI, Acetyltransferases General function prediction only 146303714 Nonpathogen - hypothetical protein Msed_0934 1 None None None 146304435 Common - AAA ATPase, central domain protein Msed_1672 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 146302847 Nonpathogen - RNA polymerase Rpb4 Msed_0062 14 COG1460 COG1460, Uncharacterized protein conserved in archaea Function unknown 146302984 Common - CobB/CobQ domain protein glutamine amidotransferase Msed_0199 150 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 146304936 Nonpathogen - hypothetical protein Msed_2189 2 None None None 146304258 Nonpathogen - hypothetical protein Msed_1493 2 None None None 146304721 Nonpathogen - hypothetical protein Msed_1973 15 COG1590 COG1590, Uncharacterized conserved protein Function unknown 146304506 Common - type III restriction enzyme, res subunit Msed_1743 152 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 146303127 Common - ACT domain-containing protein Msed_0342 44 COG3830 COG3830, ACT domain-containing protein Signal transduction mechanisms 146303880 Common - thiamine pyrophosphate enzyme TPP binding domain protein Msed_1108 217 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 146303322 Nonpathogen - protein of unknown function DUF929 Msed_0539 3 None None None 146304052 Common - Carboxymethylenebutenolidase Msed_1285 112 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 146304931 Nonpathogen - hypothetical protein Msed_2184 2 COG2378 COG2378, Predicted transcriptional regulator Transcription 146305008 Nonpathogen - hypothetical protein Msed_2262 2 None None None 146304635 Nonpathogen - hypothetical protein Msed_1887 2 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 146303728 Nonpathogen - hypothetical protein Msed_0948 1 None None None 146304044 Nonpathogen - HEPN domain protein Msed_1277 9 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 146304420 Common - FeS assembly protein SufB Msed_1657 182 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 146304012 Nonpathogen - hypothetical protein Msed_1244 2 None None None 146303376 Nonpathogen - MscS Mechanosensitive ion channel Msed_0593 5 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 146303283 Nonpathogen - Antibiotic biosynthesis monooxygenase Msed_0499 6 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 146303560 Nonpathogen - hypothetical protein Msed_0777 4 None None None 146304162 Nonpathogen - hypothetical protein Msed_1396 3 None None None 146304697 Common hisH imidazole glycerol phosphate synthase subunit HisH Msed_1949 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 146302862 Common - exosome complex exonuclease Rrp41 Msed_0077 93 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 146304216 Common - triosephosphate isomerase Msed_1451 134 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 146302858 Nonpathogen - Ribonuclease P-related protein Msed_0073 7 COG1369 POP5, RNase P/RNase MRP subunit POP5 Translation, ribosomal structure and biogenesis 146303586 Nonpathogen - Vitamin K epoxide reductase Msed_0803 6 COG4243 COG4243, Predicted membrane protein Function unknown 146304976 Nonpathogen - hypothetical protein Msed_2230 4 None None None 146303045 Nonpathogen - metallopeptidase-like protein Msed_0260 6 COG4900 COG4900, Predicted metallopeptidase General function prediction only 146304033 Common - Mn2+ and Fe2+ transporter of the NRAMP family-like protein Msed_1265 52 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 146302992 Nonpathogen - peptidyl-tRNA hydrolase Msed_0207 34 COG1990 COG1990, Uncharacterized conserved protein Function unknown 146303271 Common - putative signal transduction protein with CBS domains Msed_0486 191 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 146303621 Common - DNA topoisomerase, type IA, central domain protein Msed_0839 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 146303704 Common - NADH ubiquinone oxidoreductase, 20 kDa subunit Msed_0924 78 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 146304251 Nonpathogen - hypothetical protein Msed_1486 3 None None None 146304245 Common - biotin/lipoate A/B protein ligase Msed_1480 55 COG0095 LplA, Lipoate-protein ligase A Coenzyme metabolism 146304897 Common - protein of unknown function UPF0047 Msed_2150 137 COG0432 COG0432, Uncharacterized conserved protein Function unknown 146304587 Nonpathogen - hypothetical protein Msed_1826 2 None None None 146303345 Nonpathogen - hypothetical protein Msed_0562 2 None None None 146302935 Common - ATP-dependent DNA ligase Msed_0150 109 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 146304062 Common - dihydrodipicolinate synthetase Msed_1296 227 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 146304971 Common - Mn2+-dependent serine/threonine protein kinase Msed_2225 38 COG3642 COG3642, Mn2+-dependent serine/threonine protein kinase Signal transduction mechanisms 146303372 Nonpathogen - PaREP1 domain containing protein Msed_0589 4 None None None 146304796 Common - putative molybdenum cofactor biosynthesis protein C Msed_2048 196 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 146304896 Common - AIR synthase related protein domain protein Msed_2149 58 COG1973 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 146303721 Nonpathogen - Abortive infection protein Msed_0941 2 None None None 146304429 Nonpathogen - peptidase S26B, signal peptidase Msed_1666 5 None None None 146302972 Nonpathogen - glutamine amidotransferase-like protein Msed_0187 9 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 146303133 Nonpathogen - hypothetical protein Msed_0348 2 None None None 146304194 Common - NADH-ubiquinone oxidoreductase, chain 49kDa Msed_1429 191 COG3261 HycE, Ni,Fe-hydrogenase III large subunit Energy production and conversion 146304326 Nonpathogen - transcriptional regulator, TrmB Msed_1563 4 COG3355 COG3355, Predicted transcriptional regulator Transcription 146302943 Nonpathogen - hypothetical protein Msed_0158 4 None None None 146304944 Nonpathogen - protein of unknown function DUF1286 Msed_2197 4 None None None 146304381 Common - Carbonic anhydrase/acetyltransferase isoleucine patch superfamily-like protein Msed_1618 227 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 146303696 Nonpathogen - hydrogenase maturation protease Msed_0916 1 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 146303388 Nonpathogen - hypothetical protein Msed_0605 4 COG2222 AgaS, Predicted phosphosugar isomerases Cell envelope biogenesis, outer membrane 146303632 Common - hypothetical protein Msed_0850 13 COG3391 COG3391, Uncharacterized conserved protein Function unknown 146303027 Common - heat shock protein HtpX Msed_0242 184 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 146304059 Common - SMP-30/Gluconolaconase/LRE domain protein Msed_1292 62 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 146303567 Nonpathogen - hypothetical protein Msed_0784 1 None None None 146304743 Nonpathogen - protein of unknown function DUF125, transmembrane Msed_1995 2 None None None 146305032 Common - ribose 5-phosphate isomerase Msed_2287 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 146303863 Common - dihydrolipoamide dehydrogenase Msed_1091 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 146303514 Nonpathogen - methyltransferase small Msed_0731 33 COG2263 COG2263, Predicted RNA methylase Translation, ribosomal structure and biogenesis 146304615 Common - DEAD_2 domain protein Msed_1867 45 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 146304717 Nonpathogen - hypothetical protein Msed_1969 2 COG5491 VPS24, Conserved protein implicated in secretion Cell motility and secretion 146303186 Common - AMP-dependent synthetase and ligase Msed_0401 225 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 146302889 Common rpl5p 50S ribosomal protein L5P Msed_0104 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 146304227 Common fumC fumarate hydratase Msed_1462 236 COG0114 FumC, Fumarase Energy production and conversion 146303155 Nonpathogen - peroxiredoxins-like protein Msed_0370 2 COG2044 COG2044, Predicted peroxiredoxins General function prediction only 146304853 Nonpathogen - hypothetical protein Msed_2105 2 None None None 146304691 Common hisG ATP phosphoribosyltransferase Msed_1943 214 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 146305023 Common - small GTP-binding protein Msed_2277 219 COG2262 HflX, GTPases General function prediction only 146304147 Common - ABC-type dipeptide/oligopeptide/nickel transport systems permease components-like protein Msed_1381 98 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 146302827 Common rps10p 30S ribosomal protein S10P Msed_0042 238 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 146303298 Common - Radical SAM domain protein Msed_0515 84 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 146302833 Common ribH riboflavin synthase subunit beta Msed_0048 216 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 146303891 Common - amino acid permease-associated region Msed_1121 86 COG0833 LysP, Amino acid transporters Amino acid transport and metabolism 146304542 Common - TatD-related deoxyribonuclease Msed_1779 212 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 146303434 Nonpathogen - type II secretion system protein Msed_0651 10 COG1955 FlaJ, Archaeal flagella assembly protein J Cell motility and secretion / Intracellular trafficking and secretion 146303161 Common - hypothetical protein Msed_0376 22 COG3391 COG3391, Uncharacterized conserved protein Function unknown 146305016 Nonpathogen - hypothetical protein Msed_2270 3 None None None 146303330 Common - exsB protein Msed_0547 177 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 146302951 Common - putative transcriptional regulator, AsnC family Msed_0166 131 COG1522 Lrp, Transcriptional regulators Transcription 146303288 Common - plasma-membrane proton-efflux P-type ATPase Msed_0505 232 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 146304307 Nonpathogen - hypothetical protein Msed_1544 3 None None None 146304991 Common - sirohydrochlorin cobaltochelatase Msed_2245 53 COG2138 COG2138, Uncharacterized conserved protein Function unknown 146304603 Common - ATPase, BadF/BadG/BcrA/BcrD type Msed_1855 53 COG2971 COG2971, Predicted N-acetylglucosamine kinase Carbohydrate transport and metabolism 146303536 Nonpathogen - membrane protein-like protein Msed_0753 6 COG3371 COG3371, Predicted membrane protein Function unknown 146302880 Common rps19p 30S ribosomal protein S19P Msed_0095 219 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 146304661 Common - methionyl-tRNA synthetase Msed_1913 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146304466 Common - ornithine carbamoyltransferase Msed_1703 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 146303732 Nonpathogen - hypothetical protein Msed_0953 1 None None None 146304266 Common - sodium/hydrogen exchanger Msed_1501 21 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 146304404 Nonpathogen - hypothetical protein Msed_1641 2 None None None 146302791 Common - putative adenylyl cyclase CyaB Msed_0006 36 COG1437 CyaB, Adenylate cyclase, class 2 (thermophilic) Nucleotide transport and metabolism 146304163 Nonpathogen - transcriptional regulator, TrmB Msed_1397 3 COG3355 COG3355, Predicted transcriptional regulator Transcription 146304678 Nonpathogen - magnesium-dependent phosphatase-1 Msed_1930 8 COG4996 COG4996, Predicted phosphatase General function prediction only 146302793 Nonpathogen - hypothetical protein Msed_0008 2 None None None 146303262 Nonpathogen - hypothetical protein Msed_0477 2 None None None 146304585 Common - succinyl-diaminopimelate desuccinylase Msed_1823 175 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 146303508 Nonpathogen - hypothetical protein Msed_0725 6 None None None 146303088 Common - hypothetical protein Msed_0303 5 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 146303869 Common - protein of unknown function DUF81 Msed_1097 166 COG0730 COG0730, Predicted permeases General function prediction only 146303991 Common - major facilitator superfamily MFS_1 Msed_1222 133 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146303359 Common - Fmu (Sun) domain protein Msed_0576 199 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 146303309 Nonpathogen - PaREP1 domain containing protein Msed_0526 5 None None None 146303291 Common - pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit Msed_0508 62 COG1144 COG1144, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit Energy production and conversion 146302801 Nonpathogen purP 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase Msed_0016 20 COG1759 COG1759, ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases) General function prediction only 146303169 Common - Enoyl-CoA hydratase/isomerase Msed_0384 181 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 146304345 Common - Succinate--CoA ligase (ADP-forming) Msed_1582 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 146303352 Nonpathogen - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Msed_0569 5 COG0348 NapH, Polyferredoxin Energy production and conversion 146303842 Nonpathogen - hypothetical protein Msed_1070 2 None None None 146304955 Nonpathogen tfb transcription initiation factor IIB Msed_2209 34 COG1405 SUA7, Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB Transcription 146303500 Nonpathogen - regulatory protein, ArsR Msed_0717 7 COG3398 COG3398, Uncharacterized protein conserved in archaea Function unknown 146302899 Common - preprotein translocase subunit SecY Msed_0114 77 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 146303583 Common - protein of unknown function DUF929 Msed_0800 4 None None None 146303748 Common - putative signal-transduction protein with CBS domains Msed_0970 6 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 146303964 Nonpathogen - hypothetical protein Msed_1195 1 None None None 146303211 Common - major facilitator superfamily MFS_1 Msed_0426 120 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 146302890 Nonpathogen rps14P 30S ribosomal protein S14P Msed_0105 33 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 146303097 Common - major facilitator superfamily MFS_1 Msed_0312 218 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146304711 Common - aspartate carbamoyltransferase regulatory subunit Msed_1963 64 COG1781 PyrI, Aspartate carbamoyltransferase, regulatory subunit Nucleotide transport and metabolism 146303232 Nonpathogen - hypothetical protein Msed_0447 2 None None None 146304709 Common pyrC dihydroorotase Msed_1961 209 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 146302924 Nonpathogen - hypothetical protein Msed_0139 1 None None None 146304751 Common - Homoserine dehydrogenase Msed_2003 218 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 146303661 Common - major facilitator superfamily MFS_1 Msed_0881 86 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 146304010 Nonpathogen - TRASH domain protein Msed_1242 3 None None None 146303929 Common - CRISPR-associated RAMP protein, SSO1426 family Msed_1160 17 COG1337 COG1337, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 146303394 Common - Uncharacterized MobA-related protein-like protein Msed_0611 100 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 146303601 Nonpathogen - hypothetical protein Msed_0818 2 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 146304461 Common - threonine synthase Msed_1698 160 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 146303267 Nonpathogen - hypothetical protein Msed_0482 1 None None None 146304271 Common - biotin/lipoate A/B protein ligase Msed_1506 56 COG0095 LplA, Lipoate-protein ligase A Coenzyme metabolism 146304540 Common - fumarylacetoacetate (FAA) hydrolase Msed_1777 146 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 146304547 Nonpathogen - tRNA CCA-pyrophosphorylase Msed_1784 34 COG1746 CCA1, tRNA nucleotidyltransferase (CCA-adding enzyme) Translation, ribosomal structure and biogenesis 146304172 Common - Creatininase Msed_1406 91 COG1402 COG1402, Uncharacterized protein, putative amidase General function prediction only 146304379 Common - beta-ribofuranosylaminobenzene 5'-phosphate synthase family Msed_1616 35 COG1907 COG1907, Predicted archaeal sugar kinases General function prediction only 146303529 Nonpathogen - RNAse P, Rpr2/Rpp21 subunit Msed_0746 22 COG2023 RPR2, RNase P subunit RPR2 Translation, ribosomal structure and biogenesis 146303922 Nonpathogen - hypothetical protein Msed_1153 2 None None None 146303003 Common - Uroporphyrinogen III synthase HEM4 Msed_0218 16 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 146304372 Common - putative molybdenum cofactor biosynthesis protein A Msed_1609 207 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 146305031 Nonpathogen - hypothetical protein Msed_2285 2 None None None 146304077 Nonpathogen - OsmC family protein Msed_1311 5 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 146303611 Common - aminotransferase, class V Msed_0828 170 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 146304491 Nonpathogen - transcription factor Msed_1728 34 COG2101 SPT15, TATA-box binding protein (TBP), component of TFIID and TFIIIB Transcription 146304159 Nonpathogen - peptidase M28 Msed_1393 3 COG4882 COG4882, Predicted aminopeptidase, Iap family General function prediction only 146303530 Nonpathogen - ribosome biogenesis protein Msed_0747 18 COG1756 Mra1, Uncharacterized conserved protein Function unknown 146303864 Common - Pirin domain protein Msed_1092 148 COG1741 COG1741, Pirin-related protein General function prediction only 146303731 Nonpathogen - hypothetical protein Msed_0952 4 None None None 146303200 Common - NADH:flavin oxidoreductase/NADH oxidase Msed_0415 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 146304705 Common - multiple antibiotic resistance (MarC)-related protein Msed_1957 104 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 146304998 Nonpathogen rpl37e 50S ribosomal protein L37e Msed_2252 29 COG2126 RPL37A, Ribosomal protein L37E Translation, ribosomal structure and biogenesis 146303328 Nonpathogen - hypothetical protein Msed_0545 1 None None None 146304331 Common - ExsB family protein Msed_1568 118 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 146303639 Nonpathogen - hypothetical protein Msed_0858 3 None None None 146303655 Common - metallophosphoesterase Msed_0875 30 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 146304016 Common - electron transfer flavoprotein, alpha subunit Msed_1248 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 146303522 Nonpathogen - nucleic acid-binding protein consists of a PIN domain and a Zn-ribbon module-like protein Msed_0739 30 COG1439 COG1439, Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module General function prediction only 146303471 Common - putative transcriptional regulator, AsnC family Msed_0688 173 COG1522 Lrp, Transcriptional regulators Transcription 146303447 Nonpathogen - protein of unknown function DUF1152 Msed_0664 12 COG4034 COG4034, Uncharacterized protein conserved in archaea Function unknown 146303224 Common - Deoxyribodipyrimidine photo-lyase Msed_0439 132 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 146304157 Common - deoxyUTP pyrophosphatase Msed_1391 33 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 146303234 Common - Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B Msed_0449 95 COG3384 COG3384, Uncharacterized conserved protein Function unknown 146303411 Nonpathogen - hypothetical protein Msed_0628 2 None None None 146302840 Nonpathogen - 50S ribosomal protein L14e Msed_0055 18 COG2163 RPL14A, Ribosomal protein L14E/L6E/L27E Translation, ribosomal structure and biogenesis 146304116 Nonpathogen - hypothetical protein Msed_1350 4 COG4829 CatC1, Muconolactone delta-isomerase Secondary metabolites biosynthesis, transport, and catabolism 146303396 Nonpathogen - GHMP kinase Msed_0613 31 COG1829 COG1829, Predicted archaeal kinase (sugar kinase superfamily) General function prediction only 146302900 Nonpathogen - adenylate kinase Msed_0115 24 COG2019 AdkA, Archaeal adenylate kinase Nucleotide transport and metabolism 146304057 Common - Propanoyl-CoA C-acyltransferase Msed_1290 91 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 146304083 Nonpathogen - hypothetical protein Msed_1317 3 None None None 146304647 Common - NADH dehydrogenase subunit I Msed_1899 194 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 146303767 Nonpathogen - hypothetical protein Msed_0991 8 None None None 146303933 Nonpathogen - protein of unknown function DUF324 Msed_1164 3 COG1337 COG1337, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 146304925 Common - tryptophanyl-tRNA synthetase Msed_2178 95 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 146303516 Nonpathogen - transcriptional regulator containing an HTH domain fused to a Zn-ribbon-like protein Msed_0733 18 COG3357 COG3357, Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon Transcription 146303936 Nonpathogen - hypothetical protein Msed_1167 2 None None None 146304713 Common pyrE orotate phosphoribosyltransferase Msed_1965 236 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 146304823 Nonpathogen - hypothetical protein Msed_2075 2 None None None 146303854 Nonpathogen - hypothetical protein Msed_1082 3 COG3370 COG3370, Uncharacterized protein conserved in archaea Function unknown 146304242 Common - OsmC family protein Msed_1477 15 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 146304610 Nonpathogen - RNA polymerase, dimerisation Msed_1862 17 COG1761 RPB11, DNA-directed RNA polymerase, subunit L Transcription 146304406 Nonpathogen - hypothetical protein Msed_1643 2 None None None 146304811 Common - dihydrodipicolinate synthetase Msed_2063 234 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 146304843 Common - putative alpha-isopropylmalate/homocitrate synthase family transferase Msed_2095 213 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 146303738 Common - Radical SAM domain protein Msed_0959 106 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 146304094 Nonpathogen - hypothetical protein Msed_1328 2 COG3354 FlaG, Putative archaeal flagellar protein G Cell motility and secretion 146304102 Nonpathogen - hypothetical protein Msed_1336 1 None None None 146304356 Nonpathogen - hypothetical protein Msed_1593 1 None None None 146304596 Common - glucose-1-phosphate thymidyltransferase Msed_1845 239 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 146303574 Nonpathogen - hypothetical protein Msed_0791 3 COG2522 COG2522, Predicted transcriptional regulator General function prediction only 146305025 Nonpathogen - Transcription factor TFIIE, alpha subunit Msed_2279 32 COG1675 TFA1, Transcription initiation factor IIE, alpha subunit Transcription 146303337 Common - protein of unknown function DUF224, cysteine-rich region domain protein Msed_0554 149 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 146302811 Common upp uracil phosphoribosyltransferase Msed_0026 164 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 146304123 Nonpathogen - hypothetical protein Msed_1357 5 COG4831 COG4831, Uncharacterized conserved protein Function unknown 146304576 Common - glycosyl transferase, group 1 Msed_1814 79 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 146302789 Nonpathogen - nicotinamide-nucleotide adenylyltransferase Msed_0004 33 COG1056 NadR, Nicotinamide mononucleotide adenylyltransferase Coenzyme metabolism 146304026 Nonpathogen - hypothetical protein Msed_1258 5 COG3432 COG3432, Predicted transcriptional regulator Transcription 146303918 Nonpathogen - CRISPR-associated protein Cas2 Msed_1149 14 COG1343 COG1343, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 146303877 Nonpathogen - hypothetical protein Msed_1105 7 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 146304989 Common - translation initiation factor IF-2 subunit gamma Msed_2243 249 COG5257 GCD11, Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase) Translation, ribosomal structure and biogenesis 146304947 Nonpathogen - Sulfolobus plasmid regulator Msed_2201 2 None None None 146303034 Nonpathogen - hypothetical protein Msed_0249 2 None None None 146303543 Common - protein of unknown function DUF87 Msed_0760 104 COG0433 COG0433, Predicted ATPase General function prediction only 146303312 Nonpathogen - hypothetical protein Msed_0529 3 None None None 146304830 Nonpathogen - AAA ATPase Msed_2082 12 COG0433 COG0433, Predicted ATPase General function prediction only 146303930 Nonpathogen - CRISPR-associated RAMP protein, SSO1426 family Msed_1161 9 COG1337 COG1337, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 146303011 Nonpathogen - hypothetical protein Msed_0226 6 None None None 146303822 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Msed_1049 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 146304992 Common - ribonuclease H Msed_2246 41 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 146304437 Common - aminotransferase, class V Msed_1674 168 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 146302820 Common - DNA-directed RNA polymerase subunit A'' Msed_0035 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 146304679 Common - GTP-binding protein, HSR1-related Msed_1931 90 COG1161 COG1161, Predicted GTPases General function prediction only 146303060 Common - 4-aminobutyrate aminotransferase Msed_0275 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 146304874 Nonpathogen - hypothetical protein Msed_2127 11 COG4046 COG4046, Uncharacterized protein conserved in archaea Function unknown 146303786 Common - phosphoesterase Msed_1010 35 COG3511 PlcC, Phospholipase C Cell envelope biogenesis, outer membrane 146303052 Common - AMP-dependent synthetase and ligase Msed_0267 216 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 146304280 Common - protein of unknown function DUF6, transmembrane Msed_1515 101 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 146304735 Common - Argininosuccinate synthase Msed_1987 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 146304238 Nonpathogen - hypothetical protein Msed_1473 2 None None None 146302915 Nonpathogen - putative transcriptional regulator Msed_0130 2 COG2345 COG2345, Predicted transcriptional regulator Transcription 146304023 Common - dTDP-4-dehydrorhamnose reductase Msed_1255 182 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 146303770 Common - flavin reductase domain protein, FMN-binding Msed_0994 101 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 146304196 Common - hydrogenase 4 subunit B Msed_1431 207 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 146304218 Common - hypothetical protein Msed_1453 11 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146304804 Common - LAO/AO transport system ATPase Msed_2056 99 COG1703 ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family Amino acid transport and metabolism 146303422 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Msed_0639 105 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 146304689 Nonpathogen - hypothetical protein Msed_1941 2 None None None 146305006 Nonpathogen rps17E 30S ribosomal protein S17e Msed_2260 30 COG1383 RPS17A, Ribosomal protein S17E Translation, ribosomal structure and biogenesis 146304132 Common - Deoxyribonuclease V Msed_1366 73 COG1515 Nfi, Deoxyinosine 3'endonuclease (endonuclease V) DNA replication, recombination, and repair 146304915 Nonpathogen - hypothetical protein Msed_2168 2 None None None 146302999 Common hemA glutamyl-tRNA reductase Msed_0214 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 146304384 Common - protein of unknown function DUF711 Msed_1621 47 COG2848 COG2848, Uncharacterized conserved protein Function unknown 146304917 Common - Rhomboid family protein Msed_2170 28 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 146303036 Common - ABC-2 type transporter Msed_0251 169 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 146303477 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Msed_0694 201 COG2875 CobM, Precorrin-4 methylase Coenzyme metabolism 146303461 Common - HAD-superfamily hydrolase, subfamily IIA Msed_0678 93 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 146304107 Common - hypothetical protein Msed_1341 14 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 146304783 Nonpathogen - hypothetical protein Msed_2035 12 COG1645 COG1645, Uncharacterized Zn-finger containing protein General function prediction only 146303892 Common - Malate/L-lactate dehydrogenase Msed_1122 67 COG2055 COG2055, Malate/L-lactate dehydrogenases Energy production and conversion 146303682 Nonpathogen - protein of unknown function DUF973 Msed_0902 2 None None None 146303135 Common - ABC transporter related Msed_0350 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 146304508 Nonpathogen - hypothetical protein Msed_1745 2 None None None 146303415 Common - thioredoxin reductase Msed_0632 246 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 146304535 Common - major facilitator superfamily MFS_1 Msed_1772 127 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146304790 Nonpathogen - hypothetical protein Msed_2042 6 None None None 146303777 Common - major facilitator superfamily MFS_1 Msed_1001 214 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 146304869 Common - alpha/beta hydrolase fold Msed_2122 177 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 146304316 Common - hypothetical protein Msed_1553 41 COG3634 AhpF, Alkyl hydroperoxide reductase, large subunit Posttranslational modification, protein turnover, chaperones 146304208 Nonpathogen - hypothetical protein Msed_1443 2 None None None 146304801 Nonpathogen - regulatory protein, ArsR Msed_2053 5 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 146304767 Nonpathogen - hypothetical protein Msed_2019 2 None None None 146304445 Nonpathogen - Dehydrogenase (flavoprotein)-like protein Msed_1682 10 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 146304484 Nonpathogen - 30S ribosomal protein S30e Msed_1721 10 COG4919 COG4919, Ribosomal protein S30 Translation, ribosomal structure and biogenesis 146303214 Nonpathogen - hypothetical protein Msed_0429 5 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 146303459 Common - succinate dehydrogenase iron-sulfur subunit Msed_0676 202 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 146303488 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Msed_0705 26 COG4934 COG4934, Predicted protease Posttranslational modification, protein turnover, chaperones 146304298 Nonpathogen - PilT protein domain protein Msed_1534 2 COG4374 COG4374, Uncharacterized protein conserved in bacteria Function unknown 146303147 Common - oxidoreductase, molybdopterin binding Msed_0362 133 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 146304142 Common - binding-protein-dependent transport systems inner membrane component Msed_1376 78 COG4986 COG4986, ABC-type anion transport system, duplicated permease component Inorganic ion transport and metabolism 146304004 Common - SMC domain protein Msed_1235 19 COG1106 COG1106, Predicted ATPases General function prediction only 146303810 Common - thiamine pyrophosphate enzyme, central region Msed_1037 222 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 146303668 Common - bifunctional urease subunit gamma/beta Msed_0888 96 COG0832 UreB, Urea amidohydrolase (urease) beta subunit Amino acid transport and metabolism 146303086 Nonpathogen - hypothetical protein Msed_0301 1 None None None 146303274 Nonpathogen - DNA polymerase, beta domain protein region Msed_0489 4 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 146302986 Common - thiamine pyrophosphate enzyme, central region Msed_0201 220 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 146304201 Nonpathogen - hypothetical protein Msed_1436 8 COG5592 COG5592, Uncharacterized conserved protein Function unknown 146303952 Nonpathogen - transcriptional regulator, AbrB family Msed_1183 2 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 146304786 Nonpathogen - hypothetical protein Msed_2038 2 None None None 146303959 Nonpathogen - transcriptional regulator, TrmB Msed_1190 2 COG2512 COG2512, Uncharacterized membrane-associated protein/domain Function unknown 146304521 Nonpathogen - pseudouridylate synthase-like protein Msed_1758 28 COG1258 COG1258, Predicted pseudouridylate synthase Translation, ribosomal structure and biogenesis