Mycobacterium smegmatis str. MC2 155, complete genome NC_008596 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 118467586 Common - transcriptional regulator, GntR family protein MSMEG_3345 134 COG1802 GntR, Transcriptional regulators Transcription 118471247 Common - putative cytochrome P450 123 MSMEG_4818 68 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118471653 Common - carbon-nitrogen hydrolase family protein MSMEG_2988 198 COG0388 COG0388, Predicted amidohydrolase General function prediction only 118467878 Common - ABC nitrate/sulfonate/bicarbonate family protein transporter, inner membrane subunit, putative MSMEG_6495 81 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 118468881 Common - RNA methyltransferase, TrmH family protein, group 2 MSMEG_1636 156 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 118468852 Common - betaine aldehyde dehydrogenase MSMEG_5815 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118471629 Common - peptidoglycan-binding LysM MSMEG_5526 190 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 118471478 Common - secreted protein MSMEG_6202 66 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 118472702 Common trpE anthranilate synthase component I MSMEG_3217 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 118471724 Common - ATP-dependent DNA helicase MSMEG_5935 224 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 118470414 Common - hypothetical protein MSMEG_5215 11 None None None 118472177 Common - halogenase MSMEG_6768 36 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 118473144 Common adk adenylate kinase MSMEG_1484 230 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 118467984 Common - type II/IV secretion system protein MSMEG_6169 204 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 118467933 Common - hypothetical protein MSMEG_6455 1 None None None 118470650 Common - hypothetical protein MSMEG_1170 1 None None None 118470767 Common - indole-3-pyruvate decarboxylase MSMEG_5735 197 COG3961 COG3961, Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only 118470848 Common - polyamine-binding lipoprotein MSMEG_3280 125 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 118472793 Common - porin MSMEG_5483 2 None None None 118469489 Common - acyl-CoA dehydrogenase, middle domain protein MSMEG_0578 136 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473952 Common - PfkB-family protein carbohydrate kinase MSMEG_3785 126 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 118473651 Common - hypothetical protein MSMEG_0145 7 COG3619 COG3619, Predicted membrane protein Function unknown 118471856 Common - mosc domain protein MSMEG_3483 85 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 118470992 Common - phosphotyrosine protein phosphatase ptpb MSMEG_0100 49 COG2365 COG2365, Protein tyrosine/serine phosphatase Signal transduction mechanisms 118472830 Common - thymidylate synthase MSMEG_2744 76 COG0384 COG0384, Predicted epimerase, PhzC/PhzF homolog General function prediction only 118471414 Common - oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_5204 238 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118470765 Common - hypothetical protein MSMEG_5363 2 None None None 118473399 Common - hypothetical protein MSMEG_1773 17 None None None 118471103 Common - propionyl-CoA carboxylase beta chain MSMEG_6391 202 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 118468277 Common - putative beta-1,3-glucanase MSMEG_0645 32 COG2273 SKN1, Beta-glucanase/Beta-glucan synthetase Carbohydrate transport and metabolism 118468648 Common - alpha/beta hydrolase fold family protein MSMEG_2409 121 COG0657 Aes, Esterase/lipase Lipid metabolism 118469636 Common - non-ribosomal peptide synthetase MSMEG_6137 183 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118469628 Common - hydrolase, alpha/beta fold family protein MSMEG_1352 41 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118473415 Pathogen - hypothetical protein MSMEG_0701 1 None None None 118467840 Common - hypothetical protein MSMEG_5934 1 None None None 118470775 Common - putative esterase family protein MSMEG_1034 27 COG0627 COG0627, Predicted esterase General function prediction only 118473200 Common xerC site-specific tyrosine recombinase XerC MSMEG_2515 227 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 118472350 Common - transporter MSMEG_3267 202 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 118471225 Common - NAD dependent epimerase/dehydratase family protein MSMEG_2941 35 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118472573 Common cysS cysteinyl-tRNA synthetase MSMEG_4189 242 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 118471493 Common - hypothetical protein MSMEG_4321 16 None None None 118469524 Common - deoxyribose-phosphate aldolase superfamily protein MSMEG_4662 13 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 118473333 Common - beta-glucosidase MSMEG_2556 88 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 118473035 Common pabB para-aminobenzoate synthase component I MSMEG_5446 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 118467541 Common - hypothetical protein MSMEG_1419 9 None None None 118471518 Common - NAD-binding protein MSMEG_2496 228 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 118467599 Common - hypothetical protein MSMEG_2967 95 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 118471471 Common - alpha subunit of malonate decarboxylase MSMEG_6657 27 COG4670 COG4670, Acyl CoA:acetate/3-ketoacid CoA transferase Lipid metabolism 118470249 Common - eptc-inducible aldehyde dehydrogenase MSMEG_0900 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118473901 Common - ABC-type multidrug transport system ATPase component MSMEG_5312 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 118467886 Common - hypothetical protein MSMEG_2767 3 None None None 118468316 Common - hypothetical protein MSMEG_5549 12 None None None 118473913 Common - competence protein MSMEG_4573 96 COG0658 ComEC, Predicted membrane metal-binding protein General function prediction only 118468736 Common mtnN MTA/SAH nucleosidase MSMEG_1753 110 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 118471205 Common - xanthine/uracil permeases family protein MSMEG_1293 135 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 118468999 Common - short-chain dehydrogenase MSMEG_4722 219 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118473931 Common - FwdC/FmdC family protein MSMEG_6262 60 COG0070 GltB, Glutamate synthase domain 3 Amino acid transport and metabolism 118469054 Common - hypothetical protein MSMEG_2851 1 None None None 118469792 Pathogen - hypothetical protein MSMEG_4031 1 None None None 118470901 Common - AMP-binding enzyme MSMEG_4254 217 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 118469186 Common - sugar ABC transporter permease protein MSMEG_5573 153 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 118472346 Common - ABC transporter, permease/ATP-binding protein MSMEG_0017 245 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 118472188 Common - hypothetical protein MSMEG_3278 3 None None None 118467614 Common - alcohol dehydrogenase MSMEG_3375 88 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 118471231 Common - enoyl-CoA hydratase MSMEG_3362 180 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118468574 Common - hypothetical protein MSMEG_0528 30 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118469111 Common - LysR-family protein transcriptional regulator MSMEG_6882 87 COG0583 LysR, Transcriptional regulator Transcription 118473239 Common - glycosyltransferase, group I MSMEG_1208 20 None None None 118468806 Common - beta subunit of malonate decarboxylase MSMEG_6632 121 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 118467417 Common glpK glycerol kinase MSMEG_6229 179 COG0554 GlpK, Glycerol kinase Energy production and conversion 118471683 Common - hydrolase, alpha/beta fold family protein MSMEG_4295 39 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118468391 Common - aminoglycoside 2'-N-acetyltransferase (AAC(2')-Id) MSMEG_0434 7 None None None 118468184 Common - putative phosphotriesterase MSMEG_0320 35 COG1735 Php, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 118468655 Pathogen - hypothetical protein MSMEG_1402 1 None None None 118473030 Common - permease MSMEG_6060 29 COG0701 COG0701, Predicted permeases General function prediction only 118469329 Common - hypothetical protein MSMEG_5894 3 None None None 118467813 Common - hypothetical protein MSMEG_4984 10 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 118472227 Pathogen - hypothetical protein MSMEG_3711 1 None None None 118471287 Pathogen - hypothetical protein MSMEG_6274 1 None None None 118472404 Common - ISMsm1, transposase orfA MSMEG_1728 34 None None None 118473502 Common - antigen 85-C MSMEG_6396 6 COG0627 COG0627, Predicted esterase General function prediction only 118469093 Common map methionine aminopeptidase MSMEG_2587 249 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 118468712 Common - integral membrane protein MSMEG_2096 52 COG0730 COG0730, Predicted permeases General function prediction only 118467527 Common - transporter permease 2, putative MSMEG_2461 160 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 118471528 Common cyoE protoheme IX farnesyltransferase MSMEG_3105 177 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 118470081 Common - hypothetical protein MSMEG_5904 18 COG1141 Fer, Ferredoxin Energy production and conversion 118469018 Common - NLP/P60 family protein MSMEG_4256 145 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 118470224 Common - transcriptional regulator LysR family protein MSMEG_0471 172 COG0583 LysR, Transcriptional regulator Transcription 118469007 Common - putative ribosome small subunit-dependent GTPase RsgA MSMEG_1889 162 COG1162 COG1162, Predicted GTPases General function prediction only 118473938 Common - gluconolactonase MSMEG_2561 74 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 118473959 Common - possible conserved transmembrane protein MSMEG_4218 18 COG0762 COG0762, Predicted integral membrane protein Function unknown 118469275 Common hypF [NiFe] hydrogenase maturation protein HypF MSMEG_2711 111 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 118468229 Common - transcriptional regulator, GntR family protein MSMEG_5731 115 COG1802 GntR, Transcriptional regulators Transcription 118470215 Common - amino acid adenylation MSMEG_0019 221 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118467874 Common - regulatory protein MSMEG_5019 80 COG3284 AcoR, Transcriptional activator of acetoin/glycerol metabolism Secondary metabolites biosynthesis, transport, and catabolism / Transcription 118471049 Common - two-component system response regulator MSMEG_2807 138 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118473923 Common - probable conserved transmembrane protein MSMEG_3579 190 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 118468006 Common atpC F0F1 ATP synthase subunit epsilon MSMEG_4935 84 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 118471262 Common - universal stress protein family protein MSMEG_1411 10 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 118469544 Common - patatin MSMEG_5743 112 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 118468697 Common - hypothetical protein MSMEG_3613 23 COG5516 COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding General function prediction only 118468691 Common - oligopeptide transport system permease protein AppB MSMEG_4995 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118471554 Common - ferric enterobactin transport ATP-binding protein FepC MSMEG_0015 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 118471951 Pathogen - hypothetical protein MSMEG_0169 1 None None None 118470297 Common - Bacterial extracellular solute-binding protein MSMEG_5061 66 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118472503 Common - tetratricopeptide repeat family protein MSMEG_2120 52 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118472824 Pathogen - hypothetical protein MSMEG_5888 1 None None None 118469503 Common maf Maf-like protein MSMEG_1811 190 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 118469023 Common - transcriptional regulator, Crp/Fnr family protein MSMEG_6189 161 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 118472643 Common - permease membrane component MSMEG_2925 115 COG1174 OpuBB, ABC-type proline/glycine betaine transport systems, permease component Amino acid transport and metabolism 118473576 Common - conserved hypothetical protein TIGR00026 MSMEG_3356 11 None None None 118472570 Common - secreted protein MSMEG_0221 22 None None None 118469601 Common - hypothetical protein MSMEG_0833 16 None None None 118467348 Common - hypothetical protein MSMEG_3806 18 None None None 118468604 Common - NPL/P60-family protein secreted protein MSMEG_1686 117 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 118469251 Common - hypothetical protein MSMEG_5936 1 None None None 118470014 Common - transmembrane transport protein MSMEG_0164 28 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118469805 Common hutU urocanate hydratase MSMEG_1179 97 COG2987 HutU, Urocanate hydratase Amino acid transport and metabolism 118470740 Common - hypothetical protein MSMEG_1244 10 None None None 118472800 Common - hypothetical protein MSMEG_2958 3 None None None 118471743 Common - hypothetical protein MSMEG_5120 17 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 118469814 Pathogen - hypothetical protein MSMEG_3167 1 None None None 118469445 Common - oxidoreductase FAD/NAD MSMEG_6744 48 None None None 118470655 Common - hypothetical protein MSMEG_5180 1 None None None 118472936 Common - acetylcholinesterase MSMEG_1432 97 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 118468899 Common - putative sigma 54 type regulator MSMEG_3008 132 COG3284 AcoR, Transcriptional activator of acetoin/glycerol metabolism Secondary metabolites biosynthesis, transport, and catabolism / Transcription 118472868 Common - peptidase MSMEG_5523 139 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 118470552 Common - hypothetical protein MSMEG_2739 11 COG5479 COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis Cell envelope biogenesis, outer membrane 118470587 Common - cis-3-chloroacrylic acid dehalogenase, putative MSMEG_3359 3 COG1942 COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog General function prediction only 118469376 Common - putrescine importer MSMEG_0446 191 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 118469889 Common - putative acetyltransferase MSMEG_1026 14 COG3393 COG3393, Predicted acetyltransferase General function prediction only 118468068 Common - hypothetical protein MSMEG_6249 91 COG1262 COG1262, Uncharacterized conserved protein Function unknown 118470000 Common - iron-dependent peroxidase MSMEG_6567 35 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 118472677 Pathogen - hypothetical protein MSMEG_3610 1 None None None 118469830 Common - hydrophobic amino acid ABC transporter, putative MSMEG_6880 109 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 118473995 Common era GTP-binding protein Era MSMEG_4493 222 COG1159 Era, GTPase General function prediction only 118470007 Common - hypothetical protein MSMEG_0885 3 None None None 118470099 Common - hypothetical protein MSMEG_1121 3 None None None 118469090 Common - hypothetical protein MSMEG_6215 3 COG2968 COG2968, Uncharacterized conserved protein Function unknown 118468387 Common - hypothetical protein MSMEG_2436 56 COG1837 COG1837, Predicted RNA-binding protein (contains KH domain) General function prediction only 118473528 Common - transcriptional regulator, TetR family protein MSMEG_1010 23 COG1309 AcrR, Transcriptional regulator Transcription 118470271 Common - cytochrome P450 51 MSMEG_5864 10 COG1141 Fer, Ferredoxin Energy production and conversion 118473943 Common - hypothetical protein MSMEG_0370 25 COG4913 COG4913, Uncharacterized protein conserved in bacteria Function unknown 118468257 Common - hypothetical protein MSMEG_5453 1 None None None 118472827 Common - hypothetical protein MSMEG_5989 1 COG5651 COG5651, PPE-repeat proteins Cell motility and secretion 118468870 Common - hypothetical protein MSMEG_6742 3 COG5516 COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding General function prediction only 118468453 Common - lipase MSMEG_4148 124 COG0657 Aes, Esterase/lipase Lipid metabolism 118473279 Pathogen - hypothetical protein MSMEG_0009 1 None None None 118472450 Common - extracellular solute-binding protein, family protein 3 MSMEG_0114 109 COG4521 TauA, ABC-type taurine transport system, periplasmic component Inorganic ion transport and metabolism 118469265 Common - ABC transporter ATP-binding protein MSMEG_6553 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 118473845 Common - caax amino protease family protein MSMEG_5821 4 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 118472878 Common - antibiotic transporter MSMEG_0763 29 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118470527 Common - transcriptional regulator, IclR family protein MSMEG_4174 119 COG1414 IclR, Transcriptional regulator Transcription 118467723 Pathogen - hypothetical protein MSMEG_3938 1 None None None 118467350 Pathogen - hypothetical protein MSMEG_1194 1 None None None 118471940 Common - transcriptional regulator MSMEG_2682 126 COG2186 FadR, Transcriptional regulators Transcription 118471561 Common nuoF NADH-quinone oxidoreductase, F subunit MSMEG_2058 167 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 118469568 Common - HAD-superfamily protein hydrolase subfamily protein IA, variant 3, putative MSMEG_1495 5 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 118468246 Common - DNA-binding protein MSMEG_5685 16 COG5373 COG5373, Predicted membrane protein Function unknown 118467422 Common - possible chalcone synthase Pks10 MSMEG_0808 46 COG3424 BcsA, Predicted naringenin-chalcone synthase Secondary metabolites biosynthesis, transport, and catabolism 118470316 Pathogen - hypothetical protein MSMEG_4993 1 None None None 118470351 Pathogen - hypothetical protein MSMEG_1758 1 None None None 118469147 Common - hypothetical protein MSMEG_6615 3 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118469466 Common - D-aminopeptidase MSMEG_2092 45 COG3191 DmpA, L-aminopeptidase/D-esterase Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118470621 Common - probable peroxiredoxin, putative MSMEG_6683 13 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 118470605 Common - transcription factor WhiB MSMEG_1953 19 None None None 118468017 Common - CBS domain pair protein MSMEG_6234 20 None None None 118472732 Common - hypothetical protein MSMEG_2355 66 COG3176 COG3176, Putative hemolysin General function prediction only 118472816 Common - 6-O-methylguanine DNA methyltransferase, DNA binding domain subfamily protein MSMEG_1939 53 COG3695 COG3695, Predicted methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 118467841 Common - C-5 sterol desaturase MSMEG_0147 68 COG3000 ERG3, Sterol desaturase Lipid metabolism 118470361 Common - hypothetical protein MSMEG_4343 1 None None None 118468024 Common - hypothetical protein MSMEG_5816 5 COG3059 COG3059, Predicted membrane protein Function unknown 118467551 Common - hydrolase MSMEG_2913 125 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118468669 Common - TetR-family protein transcriptional regulator MSMEG_5346 118 COG1309 AcrR, Transcriptional regulator Transcription 118472982 Common - mce related protein MSMEG_1147 17 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118474030 Common - ErfK/YbiS/YcfS/YnhG family protein MSMEG_0674 16 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 118471238 Common - hypothetical protein MSMEG_5329 72 COG2119 COG2119, Predicted membrane protein Function unknown 118469519 Common - hypothetical protein MSMEG_3622 7 COG0829 UreH, Urease accessory protein UreH Posttranslational modification, protein turnover, chaperones 118467521 Common - putative acyl-CoA dehydrogenase MSMEG_0531 151 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118467821 Common - multidrug-efflux transporter protein MSMEG_4472 217 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118470833 Common - IS1137, transposase orfA MSMEG_2676 44 None None None 118471054 Common - MaoC like domain protein MSMEG_0371 30 COG2030 MaoC, Acyl dehydratase Lipid metabolism 118467443 Common nuoB NADH dehydrogenase subunit B MSMEG_2062 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 118469510 Common groEL chaperonin GroEL MSMEG_0880 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 118469575 Common - hypothetical protein MSMEG_0274 2 None None None 118470339 Common - NAD dependent epimerase/dehydratase family protein MSMEG_0386 232 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118473051 Pathogen - hypothetical protein MSMEG_4596 1 None None None 118473598 Common - putative DNA-binding protein MSMEG_6290 23 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 118469453 Common - hypothetical protein MSMEG_5343 2 None None None 118473749 Common - sugar-binding transcriptional regulator, LacI family protein MSMEG_3599 110 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118473322 Common - transcriptional regulator, GntR family protein MSMEG_1572 161 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 118472167 Common - transcriptional regulator, ArsR family protein MSMEG_3382 77 COG0640 ArsR, Predicted transcriptional regulators Transcription 118473905 Common - Rieske 2Fe-2S domain protein MSMEG_0657 82 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 118468780 Common - transcriptional regulator, TetR family protein MSMEG_6032 4 COG1309 AcrR, Transcriptional regulator Transcription 118469649 Common - invasin 1 MSMEG_3146 122 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 118468990 Common - transglutaminase domain protein MSMEG_3018 85 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 118472647 Common - nitrilotriacetate monooxygenase component B MSMEG_6035 123 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 118468050 Common engA GTP-binding protein EngA MSMEG_3738 237 COG1160 COG1160, Predicted GTPases General function prediction only 118467593 Pathogen - hypothetical protein MSMEG_4758 1 None None None 118471801 Common - tagatose-1,6-bisphosphate aldolase GatY MSMEG_1375 160 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 118472357 Common - LipW protein MSMEG_2568 101 COG0657 Aes, Esterase/lipase Lipid metabolism 118472515 Common - hypothetical oxidoreductase YisS MSMEG_4650 97 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 118470984 Common - oxidoreductase, molybdopterin binding MSMEG_4412 88 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 118472199 Common - transcriptional regulator, IclR family protein MSMEG_6174 118 COG1414 IclR, Transcriptional regulator Transcription 118468041 Common - methyltransferase MSMEG_0093 27 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118473270 Common - possible conserved integral membrane protein MSMEG_4241 15 None None None 118469504 Pathogen - hypothetical protein MSMEG_3680 1 None None None 118473972 Common - cyclopropane-fatty-acyl-phospholipid synthase 1 MSMEG_1351 127 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 118469366 Common - UDP-glucose 6-dehydrogenase MSMEG_5982 205 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 118467450 Common - acyl-CoA synthase MSMEG_4876 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118473135 Common gatA glutamyl-tRNA(Gln)/aspartyl-tRNA(Asn) amidotransferase, A subunit MSMEG_1088 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 118472962 Common - enoyl-CoA hydratase/isomerase MSMEG_4873 144 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118473076 Common orB 2-oxoglutarate ferredoxin oxidoreductase subunit beta MSMEG_4645 114 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 118472103 Pathogen - hypothetical protein MSMEG_5601 1 None None None 118472923 Common - probable transcriptional regulatory protein MSMEG_0742 138 COG0583 LysR, Transcriptional regulator Transcription 118468177 Common - acyl-CoA dehydrogenase MSMEG_0108 151 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472651 Common - hypothetical protein MSMEG_1768 22 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 118468632 Pathogen - hypothetical protein MSMEG_1800 1 None None None 118470541 Common - low molecular weight protein antigen 7 MSMEG_0621 2 COG4842 COG4842, Uncharacterized protein conserved in bacteria Function unknown 118471632 Common secD preprotein translocase subunit SecD MSMEG_2961 196 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 118469283 Common - amino acid permease-associated region MSMEG_3557 66 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118471733 Pathogen - hypothetical protein MSMEG_1697 1 None None None 118469843 Pathogen - hypothetical protein MSMEG_2574 1 None None None 118468508 Common - glycine betaine transporter OpuD MSMEG_1883 96 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 118473691 Common - methyltransferase, putative, family protein MSMEG_0607 33 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118470846 Common - helicase, UvrD/Rep family protein MSMEG_1941 51 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 118468210 Common - monooxygenase, flavin-binding family protein MSMEG_2038 69 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118471370 Common - putative Cell division protein FtsQ MSMEG_4225 18 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 118468751 Common - acyl-CoA dehydrogenase MSMEG_3259 38 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118471968 Common - integral membrane protein MSMEG_0468 75 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 118469642 Common - short chain dehydrogenase MSMEG_0863 200 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118468861 Common - IS1096, tnpR protein MSMEG_1002 44 None None None 118472041 Common - ABC transporter permease protein MSMEG_4386 218 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118472723 Common ackA acetate kinase MSMEG_0784 162 COG0282 ackA, Acetate kinase Energy production and conversion 118467519 Common ftsW cell division protein FtsW MSMEG_4228 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 118471505 Pathogen - hypothetical protein MSMEG_0498 1 None None None 118471147 Common - hypothetical protein MSMEG_2896 73 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118471195 Common dnaJ chaperone protein DnaJ MSMEG_4504 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 118473244 Common - hypothetical protein MSMEG_1947 30 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 118472117 Common - chorismate mutase MSMEG_2111 9 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 118473356 Pathogen - hypothetical protein MSMEG_5974 1 None None None 118473505 Common secY preprotein translocase subunit SecY MSMEG_1483 242 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 118473362 Common - hypothetical protein MSMEG_3531 1 COG5373 COG5373, Predicted membrane protein Function unknown 118473917 Pathogen - hypothetical protein MSMEG_1999 1 None None None 118468973 Common - metallo-beta-lactamase superfamily protein MSMEG_5834 17 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 118468110 Common - ATPase associated with various cellular activities, AAA_5 MSMEG_0748 87 COG0714 COG0714, MoxR-like ATPases General function prediction only 118468619 Common - IS1096, tnpR protein MSMEG_1257 44 None None None 118469217 Common metX homoserine O-acetyltransferase MSMEG_1651 130 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 118469130 Common - hypothetical protein MSMEG_5945 7 COG1434 COG1434, Uncharacterized conserved protein Function unknown 118472038 Pathogen - hypothetical protein MSMEG_2759 1 None None None 118472588 Common clpS ATP-dependent Clp protease adaptor protein ClpS MSMEG_4910 17 COG2127 COG2127, Uncharacterized conserved protein Function unknown 118468820 Common - enoyl-CoA hydratase MSMEG_5620 174 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118473089 Common ehuD ectoine/hydroxyectoine ABC transporter, permease protein EhuD MSMEG_5370 172 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 118472175 Common - hypothetical protein MSMEG_3241 3 COG5373 COG5373, Predicted membrane protein Function unknown 118470891 Common - hypothetical protein MSMEG_0344 141 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 118468158 Common pntA NAD(P) transhydrogenase subunit alpha MSMEG_4109 158 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 118468306 Common - probable sugar ABC transporter, permease protein MSMEG_0507 143 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 118471509 Common aceA isocitrate lyase MSMEG_0911 128 COG2224 AceA, Isocitrate lyase Energy production and conversion 118472908 Common - ElaA protein MSMEG_2614 83 COG2153 ElaA, Predicted acyltransferase General function prediction only 118469750 Common - LppK protein MSMEG_3904 1 None None None 118468090 Common - membrane transport protein MSMEG_6513 139 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118471604 Common cydD ABC transporter, CydDC cysteine exporter (CydDC-E) family protein, permease/ATP-binding protein CydD MSMEG_3231 201 COG4988 CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 118469997 Common moxR ATPase, MoxR family protein MSMEG_3147 178 COG0714 COG0714, MoxR-like ATPases General function prediction only 118470343 Common - NAD-dependent deacetylase MSMEG_5175 152 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 118471977 Common - hypothetical protein MSMEG_1833 17 None None None 118470696 Common - hypothetical protein MSMEG_3639 12 None None None 118471004 Common - hypothetical protein MSMEG_3482 1 None None None 118468219 Common - LysA protein MSMEG_5389 2 None None None 118473876 Common - hypothetical protein MSMEG_1340 21 None None None 118469399 Common - ABC transporter, ATP-binding protein MSMEG_6725 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 118470594 Common uvrA excinuclease ABC, A subunit MSMEG_6806 232 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 118469235 Common - glyoxylate reductase MSMEG_2529 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 118467479 Common - F420-0--gamma-glutamyl ligase MSMEG_1829 53 COG1478 COG1478, Uncharacterized conserved protein Function unknown 118471309 Common - conserved exported protein MSMEG_5272 18 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 118469116 Common - glutathione S-transferase MSMEG_5695 79 COG0435 ECM4, Predicted glutathione S-transferase Posttranslational modification, protein turnover, chaperones 118467913 Common resD DNA-binding response regulator ResD MSMEG_0994 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 118473080 Common - RNA polymerase factor sigma-70 MSMEG_0219 158 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118469258 Common - oxidoreductase MSMEG_0686 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 118469397 Common - acyl carrier protein phosphodiesterase MSMEG_3381 15 COG1182 AcpD, Acyl carrier protein phosphodiesterase Lipid metabolism 118468643 Common - oxidoreductase, FAD/FMN-binding MSMEG_6486 177 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 118468162 Common - hypothetical protein MSMEG_3149 62 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 118473629 Common - transcriptional regulator, TetR family protein MSMEG_5811 2 COG1309 AcrR, Transcriptional regulator Transcription 118468238 Common mdcG phosphoribosyl-dephospho-CoA transferase MSMEG_6631 12 None None None 118473348 Common - hypothetical protein MSMEG_3253 8 None None None 118468960 Common - two-component system sensor kinase MSMEG_2804 147 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 118469759 Common - Carboxyl transferase domain protein MSMEG_2255 162 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 118468048 Common - potassium-transporting ATPase C chain MSMEG_5394 92 COG2156 KdpC, K+-transporting ATPase, c chain Inorganic ion transport and metabolism 118469608 Common - metapyrocatechase 1 MSMEG_4865 30 COG3384 COG3384, Uncharacterized conserved protein Function unknown 118469614 Common - hypothetical protein MSMEG_0132 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 118473108 Common - transcriptional regulator, TetR family protein MSMEG_6042 49 COG1309 AcrR, Transcriptional regulator Transcription 118472202 Pathogen - hypothetical protein MSMEG_5356 1 None None None 118471012 Common msrA methionine sulfoxide reductase A MSMEG_6477 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 118468612 Common - proteasome alpha subunit MSMEG_3894 19 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 118473462 Common - hypothetical protein MSMEG_3513 27 COG4552 Eis, Predicted acetyltransferase involved in intracellular survival and related acetyltransferases General function prediction only 118471316 Common - short chain dehydrogenase MSMEG_2026 238 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118468583 Common - carotenoid oxygenase MSMEG_5609 36 COG3670 COG3670, Lignostilbene-alpha,beta-dioxygenase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 118471911 Common - hypothetical protein MSMEG_1136 1 None None None 118468301 Common rpsD 30S ribosomal protein S4 MSMEG_1523 245 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 118470242 Common - LemA protein MSMEG_3063 126 COG1704 LemA, Uncharacterized conserved protein Function unknown 118467341 Common - LppI protein MSMEG_3851 1 None None None 118473685 Common - hypothetical protein MSMEG_0636 8 None None None 118467952 Common - transcription regulator MSMEG_5777 14 COG1846 MarR, Transcriptional regulators Transcription 118467356 Common - amino acid transporter, putative MSMEG_1625 124 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118472236 Common - hypothetical protein MSMEG_1487 12 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 118470665 Common - putative HpcE protein MSMEG_2007 176 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 118473171 Common - alpha-methylacyl-CoA racemase MSMEG_4111 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118468204 Common - 2Fe-2S iron-sulfur cluster binding domain protein MSMEG_4878 95 COG0633 Fdx, Ferredoxin Energy production and conversion 118473457 Common rpsJ ribosomal protein S10 MSMEG_1435 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 118467777 Common panB 3-methyl-2-oxobutanoate hydroxymethyltransferase MSMEG_4298 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 118467864 Common - ABC transporter solute binding lipoprotein MSMEG_6865 194 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 118468486 Common - K+-dependent Na+/Ca+ exchanger related-protein MSMEG_4754 120 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 118472692 Pathogen - hypothetical protein MSMEG_1593 1 None None None 118471039 Common - hypothetical protein MSMEG_2865 4 None None None 118467448 Common - hypothetical protein MSMEG_0767 1 None None None 118468117 Common dnaN DNA polymerase III subunit beta MSMEG_0001 214 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 118471714 Common tig trigger factor MSMEG_4674 215 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 118467623 Common - putative transcriptional regulator MSMEG_0735 2 COG3226 COG3226, Uncharacterized protein conserved in bacteria Function unknown 118471269 Common - hypothetical protein MSMEG_5205 2 None None None 118470877 Common - metallopeptidase, zinc binding MSMEG_3000 86 COG2321 COG2321, Predicted metalloprotease General function prediction only 118472146 Common - transcriptional regulator MSMEG_0155 75 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 118470830 Common - enoyl-CoA hydratase/isomerase MSMEG_0259 114 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118469925 Common - cupin domain protein MSMEG_3484 8 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 118468553 Pathogen - hypothetical protein MSMEG_4749 1 None None None 118471240 Common - membrane protein, MmpL family protein MSMEG_3584 48 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118471536 Common - IS1096, tnpR protein MSMEG_4927 44 None None None 118467893 Common - methane monooxygenase component C MSMEG_1972 181 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 118469556 Common rpoA DNA-directed RNA polymerase subunit alpha MSMEG_1524 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 118469082 Common - sensor-type histidine kinase PrrB MSMEG_2793 187 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 118467410 Common scpA segregation and condensation protein A MSMEG_3742 113 COG1354 COG1354, Uncharacterized conserved protein Function unknown 118472787 Common - nudix hydrolase MSMEG_1268 76 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 118470703 Common - hypothetical protein MSMEG_0058 1 None None None 118467396 Common - hypothetical protein MSMEG_0770 1 None None None 118467734 Common - 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_1070 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471816 Common - cyclase MSMEG_4861 37 COG1878 COG1878, Predicted metal-dependent hydrolase General function prediction only 118469782 Common - aldehyde dehydrogenase MSMEG_0455 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118470216 Common - copper resistance protein D MSMEG_6437 3 COG1276 PcoD, Putative copper export protein Inorganic ion transport and metabolism 118469785 Common dcd deoxycytidine triphosphate deaminase MSMEG_0678 160 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 118474009 Common - O-antigen export system, permease protein MSMEG_6369 82 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 118473412 Common - 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase MSMEG_3515 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118468365 Common - amidase MSMEG_0485 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 118472007 Common - pyridoxamine 5'-phosphate oxidase family protein MSMEG_1668 11 COG3871 COG3871, Uncharacterized stress protein (general stress protein 26) General function prediction only 118470090 Common - alcohol dehydrogenase MSMEG_3726 78 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 118472063 Common - serine esterase, cutinase family protein MSMEG_6354 4 COG0400 COG0400, Predicted esterase General function prediction only 118472950 Common - hypothetical protein MSMEG_5376 3 None None None 118469520 Common - putative conserved exported protein MSMEG_0651 4 None None None 118471861 Common - hypothetical protein MSMEG_4755 184 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 118473714 Common - major facilitator family protein transporter MSMEG_1983 133 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118469907 Common - hypothetical protein MSMEG_0923 3 COG5373 COG5373, Predicted membrane protein Function unknown 118468756 Common - oxidoreductase, 2-nitropropane dioxygenase family protein MSMEG_1660 98 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 118470144 Common murD UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase MSMEG_4229 205 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 118468170 Common - hypothetical protein MSMEG_5292 1 None None None 118467666 Common - dihydroxyacetone kinase, L subunit MSMEG_2122 76 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 118468947 Common - butyryl-CoA dehydrogenase MSMEG_0667 155 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118471581 Common - hypothetical protein MSMEG_4414 3 COG2323 COG2323, Predicted membrane protein Function unknown 118468072 Common - SEC-C motif domain protein MSMEG_1921 88 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 118471365 Common argB acetylglutamate kinase MSMEG_3774 215 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 118471344 Common - integral membrane protein MSMEG_3838 27 COG2339 COG2339, Predicted membrane protein Function unknown 118467363 Pathogen - recombination activating protein 1 MSMEG_3720 1 None None None 118468144 Common - hypothetical protein MSMEG_6394 4 None None None 118469729 Common - hypothetical protein MSMEG_5255 2 None None None 118467652 Common - oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_5624 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118467468 Common - hypothetical protein MSMEG_2732 5 None None None 118469855 Common - glycerol uptake facilitator, MIP channel MSMEG_2124 134 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 118473783 Pathogen - hypothetical protein MSMEG_6578 1 None None None 118473768 Common - two-component system, regulatory protein MSMEG_6236 178 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118471352 Common - R3H domain-containing protein MSMEG_6941 67 COG1847 Jag, Predicted RNA-binding protein General function prediction only 118470473 Common - FAD dependent oxidoreductase, putative MSMEG_0175 42 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 118471895 Common - hypothetical protein MSMEG_0632 1 None None None 118471982 Common - major facilitator superfamily protein MFS_1 MSMEG_4980 175 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118471907 Common - integral membrane protein MSMEG_0720 7 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 118471947 Common - AMP-binding enzyme MSMEG_2216 222 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118473555 Common - nucleoside-diphosphate sugar epimerase MSMEG_3083 104 COG1090 COG1090, Predicted nucleoside-diphosphate sugar epimerase General function prediction only 118472295 Common - hypothetical protein MSMEG_0989 2 None None None 118467678 Common nadE NAD synthetase MSMEG_4617 173 COG0171 NadE, NAD synthase Coenzyme metabolism 118472552 Common - hypothetical protein MSMEG_5246 15 None None None 118472424 Common - hypothetical protein MSMEG_6365 12 None None None 118472976 Common - 3-hydroxyacyl-CoA dehydrogenase MSMEG_4110 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 118469580 Common - ISMsm5, transposase MSMEG_2805 52 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 118468942 Common - transcriptional regulator family protein MSMEG_6580 109 COG1733 COG1733, Predicted transcriptional regulators Transcription 118470720 Pathogen - hypothetical protein MSMEG_5822 1 None None None 118474000 Common - putative methyltransferase MSMEG_2413 197 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 118469292 Common - histidine kinase MSMEG_0993 219 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 118472078 Pathogen - hypothetical protein MSMEG_4223 1 None None None 118471989 Common - MmpS2 protein MSMEG_0186 1 None None None 118470467 Pathogen - hypothetical protein MSMEG_0931 1 None None None 118473797 Common - branched-chain amino acid ABC-type transport system, permease component MSMEG_2981 149 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 118470855 Common - acylphosphatase MSMEG_2422 111 COG1254 AcyP, Acylphosphatases Energy production and conversion 118471925 Common - hypothetical protein MSMEG_4129 20 COG3226 COG3226, Uncharacterized protein conserved in bacteria Function unknown 118471174 Common glmS glucosamine--fructose-6-phosphate aminotransferase, isomerizing MSMEG_5986 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 118473467 Common - transcriptional regulator, TetR family protein MSMEG_4831 35 COG1309 AcrR, Transcriptional regulator Transcription 118470820 Common - IS1096, tnpR protein MSMEG_3165 44 None None None 118472770 Common rarD RarD protein MSMEG_3176 95 COG2962 RarD, Predicted permeases General function prediction only 118473733 Pathogen - hypothetical protein MSMEG_2304 1 None None None 118469026 Pathogen - hypothetical protein MSMEG_3049 1 None None None 118469499 Common - short chain dehydrogenase family protein MSMEG_5235 235 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118473761 Common - quinone binding protein MSMEG_5910 18 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 118470497 Common - hypothetical protein MSMEG_5893 3 None None None 118468967 Pathogen - hypothetical protein MSMEG_2226 1 None None None 118469764 Common - hypothetical protein MSMEG_5317 5 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 118470687 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase MSMEG_1410 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118467803 Common - aminotransferase, class I and II family protein MSMEG_2493 221 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 118472488 Common - hypothetical protein MSMEG_1457 41 COG3193 GlcG, Uncharacterized protein, possibly involved in utilization of glycolate and propanediol General function prediction only 118470278 Common murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase MSMEG_4932 220 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 118468483 Pathogen - hypothetical protein MSMEG_1592 1 None None None 118471348 Common - hypothetical protein MSMEG_4815 1 COG2267 PldB, Lysophospholipase Lipid metabolism 118469539 Common - membrane protein MSMEG_1796 31 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 118471428 Common - acetyl-hydrolase MSMEG_3010 126 COG0657 Aes, Esterase/lipase Lipid metabolism 118471920 Common katG catalase/peroxidase HPI MSMEG_3729 98 COG0376 KatG, Catalase (peroxidase I) Inorganic ion transport and metabolism 118473256 Common - hypothetical protein MSMEG_2809 23 None None None 118470050 Pathogen - hypothetical protein MSMEG_3343 1 None None None 118472714 Pathogen - hypothetical protein MSMEG_2113 1 None None None 118467685 Common hemB delta-aminolevulinic acid dehydratase MSMEG_0956 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 118472527 Common - phosphoadenosine phosphosulfate reductase MSMEG_4528 162 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 118470102 Common soj SpoOJ regulator protein MSMEG_3743 229 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 118470896 Common - hypothetical protein MSMEG_0996 23 COG3222 COG3222, Uncharacterized protein conserved in bacteria Function unknown 118471672 Common thiL thiamine monophosphate kinase MSMEG_2398 175 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 118468545 Common - 3-isopropylmalate dehydratase large subunit MSMEG_2505 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 118473777 Common - hypothetical protein MSMEG_3884 4 COG3115 ZipA, Cell division protein Cell division and chromosome partitioning 118470923 Common edd phosphogluconate dehydratase MSMEG_0313 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 118469971 Pathogen - hypothetical protein MSMEG_2457 1 None None None 118472772 Common - RNA polymerase sigma factor SigB MSMEG_2752 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 118472128 Common - hypothetical protein MSMEG_6135 2 None None None 118467446 Common - phosphoserine aminotransferase MSMEG_5684 176 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 118467537 Common - hypothetical protein MSMEG_2906 14 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118469967 Common - hemerythrin HHE cation binding domain subfamily protein, putative MSMEG_6212 15 None None None 118473479 Common - ferric iron-binding periplasmic protein of ABC transporter MSMEG_3636 126 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 118468924 Common - 3-deoxy-7-phosphoheptulonate synthase MSMEG_4244 73 COG3200 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 118469933 Common - transport protein MSMEG_3314 65 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118470713 Common - short chain dehydrogenase MSMEG_4882 168 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118467676 Common - isoniazid inductible protein IniA MSMEG_0695 34 COG1159 Era, GTPase General function prediction only 118468845 Common - transmembrane transport protein MSMEG_5161 131 COG4147 DhlC, Predicted symporter General function prediction only 118473677 Common rhaB rhamnulokinase MSMEG_0591 77 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 118469084 Common - acyl dehydratase MSMEG_6560 37 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 118469551 Common - Rmt2 protein MSMEG_0387 11 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 118470671 Common - isoflavone reductase MSMEG_6755 9 COG1748 LYS9, Saccharopine dehydrogenase and related proteins Amino acid transport and metabolism 118471749 Common eno phosphopyruvate hydratase MSMEG_5415 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 118473191 Common truA tRNA pseudouridine synthase A MSMEG_1527 234 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 118468136 Common - hydrolase, alpha/beta hydrolase fold family protein MSMEG_6085 83 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118472605 Common - hypothetical protein MSMEG_1639 9 None None None 118469207 Common - universal stress protein family protein MSMEG_3940 37 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 118470937 Common - formate dehydrogenase, alpha subunit MSMEG_0161 213 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 118468530 Common - amidohydrolase 3 MSMEG_0263 38 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 118469352 Common prpB methylisocitrate lyase MSMEG_6646 121 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 118472467 Common - hypothetical protein MSMEG_5747 2 None None None 118472070 Common - hypothetical protein MSMEG_1662 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 118472023 Common - oxidoreductase MSMEG_1214 125 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 118471169 Common - phytase MSMEG_0772 34 COG4222 COG4222, Uncharacterized protein conserved in bacteria Function unknown 118471566 Common - dipeptidyl aminopeptidase/acylaminoacyl peptidase MSMEG_5341 33 COG2267 PldB, Lysophospholipase Lipid metabolism 118469987 Common - LpqB protein MSMEG_1876 17 None None None 118471302 Common rpsL 30S ribosomal protein S12 MSMEG_1398 246 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 118471096 Common - polyamine ABC transporter integral membrane protein MSMEG_3277 216 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 118473851 Common - lipoprotein Lpps MSMEG_0233 22 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 118470027 Common - inner-membrane translocator MSMEG_6878 147 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 118472013 Common - acyl-CoA dehydrogenase MSMEG_2208 166 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118469643 Common - IS1096, tnpA protein MSMEG_0397 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118469590 Common - NHL repeat protein MSMEG_2269 13 None None None 118473383 Common - tetratricopeptide repeat family protein MSMEG_1285 13 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 118472854 Common - esterase MSMEG_3829 137 COG0657 Aes, Esterase/lipase Lipid metabolism 118468029 Common - pyridoxal-phosphate-dependent transferase MSMEG_6246 206 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 118467855 Common - glyoxalase family protein MSMEG_5827 16 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 118469691 Common - IS1096, tnpR protein MSMEG_0801 44 None None None 118473841 Common - SIS domain protein MSMEG_5330 9 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 118469695 Common - D-alanyl-D-alanine carboxypeptidase MSMEG_2433 144 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 118472536 Pathogen - hypothetical protein MSMEG_4660 1 None None None 118467408 Common purE phosphoribosylaminoimidazole carboxylase, catalytic subunit MSMEG_1820 232 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 118468335 Common ddl D-alanyl-alanine synthetase A MSMEG_2395 211 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 118471394 Common - HAD-superfamily protein subfamily protein IB hydrolase MSMEG_3517 106 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 118469101 Common - major facilitator superfamily protein MSMEG_4058 141 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118473663 Common - virulence factor Mce family protein MSMEG_5899 29 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118467638 Common - transcriptional regulator, IclR family protein MSMEG_2386 109 COG1414 IclR, Transcriptional regulator Transcription 118469221 Common - transcriptional regulator, AraC family protein MSMEG_4655 127 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 118471918 Common - acetyl-CoA synthetase, putative MSMEG_0666 54 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 118472581 Common glgX glycogen debranching enzyme GlgX MSMEG_3186 154 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 118470752 Common - vanillate O-demethylase oxidoreductase MSMEG_4371 126 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 118468528 Pathogen - putative ferric uptake regulator MSMEG_0429 1 None None None 118473896 Common - hypothetical protein MSMEG_5497 2 None None None 118472363 Common hrcA heat-inducible transcription repressor MSMEG_4505 150 COG1420 HrcA, Transcriptional regulator of heat shock gene Transcription 118469197 Common - cyclase MSMEG_4048 37 COG1878 COG1878, Predicted metal-dependent hydrolase General function prediction only 118469066 Common - transcriptional regulator, MarR family protein MSMEG_1492 15 COG1846 MarR, Transcriptional regulators Transcription 118468498 Common - DNA-binding protein MSMEG_6794 41 None None None 118471144 Common - isomerase MSMEG_6871 119 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 118473799 Common - putative transposition helper protein MSMEG_2150 95 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 118473251 Common - ATP binding protein of ABC transporter MSMEG_1711 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 118470384 Common - cytochrome P450 hydroxylase MSMEG_4213 80 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118472921 Common ilvB acetolactate synthase 1 catalytic subunit MSMEG_2372 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 118471590 Common - arginine/ornithine transport system ATPase MSMEG_3160 99 COG1703 ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family Amino acid transport and metabolism 118470954 Common - resuscitation-promoting factor MSMEG_4643 12 None None None 118471807 Common - hypothetical protein MSMEG_5153 4 COG4982 COG4982, 3-oxoacyl- acyl-carrier protein 118472216 Common - conserved integral membrane protein MSMEG_2411 15 COG4243 COG4243, Predicted membrane protein Function unknown 118472061 Common truB tRNA pseudouridine synthase B MSMEG_2649 244 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 118468568 Common - ATP-binding protein MSMEG_3237 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 118473469 Common catA catechol 1,2-dioxygenase MSMEG_1911 50 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 118467508 Common - geranylgeranyl reductase MSMEG_2308 98 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 118469868 Common - hypothetical protein MSMEG_5349 9 None None None 118473447 Common - putative periplasmic binding protein MSMEG_2982 145 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 118468201 Common - spermidine/putrescine ABC transporter ATP-binding subunit MSMEG_3281 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 118467859 Common - hypothetical protein MSMEG_2589 15 COG4954 COG4954, Uncharacterized protein conserved in bacteria Function unknown 118472267 Common - glutamyl aminopeptidase, M42 family protein MSMEG_3273 88 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 118470188 Common - sensor histidine kinase MSMEG_4989 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 118467707 Common - hypothetical protein MSMEG_4628 3 None None None 118471777 Common - two-component system response regulator MSMEG_2806 3 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 118470812 Common - transcriptional regulator, AsnC family protein MSMEG_1663 138 COG1522 Lrp, Transcriptional regulators Transcription 118468741 Common - transcriptional regulator, IclR family protein MSMEG_3784 120 COG1414 IclR, Transcriptional regulator Transcription 118468344 Pathogen - hypothetical protein MSMEG_1956 1 None None None 118470432 Common - hypothetical protein MSMEG_2000 5 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 118472059 Common - integral membrane protein MSMEG_3671 37 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 118472474 Common - hypothetical protein MSMEG_6571 2 None None None 118470958 Common galT galactose-1-phosphate uridylyltransferase MSMEG_3691 77 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 118469324 Common - enoyl-CoA hydratase MSMEG_4846 180 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118467938 Common - ATP dependent DNA ligase MSMEG_2105 66 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 118474029 Pathogen - antigen MTB48 MSMEG_0076 1 COG5651 COG5651, PPE-repeat proteins Cell motility and secretion 118471597 Common - hypothetical protein MSMEG_1076 1 None None None 118472068 Common - GlcNAc-PI de-N-acetylase family protein MSMEG_2046 44 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 118469337 Common - hypothetical protein MSMEG_2700 14 None None None 118469979 Common - sodium:dicarboxylate symporter MSMEG_4501 160 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 118471773 Common - glucarate dehydratase MSMEG_6132 111 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 118472994 Common - acyl-CoA dehydrogenase domain protein MSMEG_6512 132 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472544 Common - oxidoreductase MSMEG_6763 7 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118472745 Common - LysR family protein transcriptional regulatory protein MSMEG_4394 179 COG0583 LysR, Transcriptional regulator Transcription 118469615 Common - hypothetical protein MSMEG_5682 7 None None None 118472335 Common - regulatory protein MSMEG_2447 22 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 118471798 Common - hypothetical protein MSMEG_2183 7 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 118473168 Common - replicative DNA helicase MSMEG_6892 221 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 118473726 Common - integral membrane protein MSMEG_4273 16 None None None 118473804 Common - endoribonuclease L-PSP superfamily protein MSMEG_1681 171 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 118472610 Common - hydrolase, NUDIX family protein MSMEG_2390 34 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 118472849 Common - hypothetical protein MSMEG_3593 109 COG1801 COG1801, Uncharacterized conserved protein Function unknown 118472119 Pathogen - hypothetical protein MSMEG_5500 1 None None None 118470047 Common - inner membrane metabolite transport protein YdfJ MSMEG_2912 180 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118472716 Common - hypothetical protein MSMEG_5697 42 COG3304 COG3304, Predicted membrane protein Function unknown 118473983 Common - GntR-family protein transcriptional regulator MSMEG_1043 201 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 118472479 Common - dihydroxyacetone kinase MSMEG_2402 50 COG1461 COG1461, Predicted kinase related to dihydroxyacetone kinase General function prediction only 118473531 Common - zinc finger, UBP-type MSMEG_0765 23 COG5207 UBP14, Isopeptidase T Posttranslational modification, protein turnover, chaperones 118469089 Common - fumarylacetoacetate hydrolase family protein MSMEG_2098 166 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 118472638 Common - putative cell division protein FtsX MSMEG_2090 67 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 118472444 Common - glycerol-3-phosphate dehydrogenase 2 MSMEG_6761 148 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 118471697 Common - aspartate aminotransferase MSMEG_6017 237 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 118473424 Common - hypothetical protein MSMEG_3544 33 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118468104 Common - hypothetical protein MSMEG_0070 1 None None None 118472417 Common - transcriptional regulator, TetR family protein MSMEG_2557 43 COG1309 AcrR, Transcriptional regulator Transcription 118470452 Common - 3-ketosteroid-delta-1-dehydrogenase MSMEG_2867 64 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 118468790 Common - hypothetical protein MSMEG_4271 1 None None None 118468787 Common - putative pyrimidine permease RutG MSMEG_4011 118 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 118467765 Common - hypothetical protein MSMEG_3328 1 None None None 118470057 Common - D-galactonate transporter MSMEG_6178 192 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118472384 Common - hypothetical cytosolic protein MSMEG_1280 11 None None None 118472093 Common - regulatory protein, MarR MSMEG_5688 28 COG1846 MarR, Transcriptional regulators Transcription 118471072 Common - putative transposase MSMEG_1863 7 None None None 118472160 Common - alpha-amylase 3 MSMEG_3576 155 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 118471074 Common - hypothetical protein MSMEG_0654 82 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118473655 Common - hypothetical protein MSMEG_5231 1 None None None 118468263 Common - hypothetical protein MSMEG_3472 10 None None None 118473763 Common - zinc-binding alcohol dehydrogenase family protein MSMEG_3615 198 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 118471870 Common - transposase MSMEG_1864 21 None None None 118467543 Common thiC thiamine biosynthesis protein ThiC MSMEG_0826 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 118470796 Common - DNA-binding protein MSMEG_3121 49 COG2345 COG2345, Predicted transcriptional regulator Transcription 118469141 Common - hypothetical protein MSMEG_4737 3 COG2327 WcaK, Uncharacterized conserved protein Function unknown 118471642 Common - iron-sulfur cluster-binding protein MSMEG_0690 106 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 118471867 Common rplR 50S ribosomal protein L18 MSMEG_1471 215 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 118469733 Common - hypothetical protein MSMEG_5998 11 None None None 118471786 Common - FHA domain protein MSMEG_0035 37 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 118469942 Common - FAD dependent oxidoreductase MSMEG_0481 29 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 118472763 Common - serine/threonine protein kinase PksC MSMEG_6206 151 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 118470745 Common - probable conserved transmembrane protein MSMEG_5613 1 None None None 118471546 Common - signal transduction histidine kinase MSMEG_0980 39 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 118473878 Pathogen - hypothetical protein MSMEG_6566 1 None None None 118471159 Pathogen - hypothetical protein MSMEG_1861 1 None None None 118469382 Common - hypothetical protein MSMEG_4688 16 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118469228 Common - IS1096, tnpR protein MSMEG_6463 44 None None None 118471437 Common - hypothetical protein MSMEG_4494 1 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 118470125 Common - propionate CoA-transferase MSMEG_4168 100 COG4670 COG4670, Acyl CoA:acetate/3-ketoacid CoA transferase Lipid metabolism 118471062 Common - serine/threonine-protein kinase PknD MSMEG_0886 145 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 118471557 Common - ABC transporter permease protein MSMEG_2635 194 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 118468577 Common - hypothetical protein MSMEG_4843 2 None None None 118472084 Common - TetR-family protein transcriptional regulator MSMEG_1509 90 COG1309 AcrR, Transcriptional regulator Transcription 118467755 Common rplS 50S ribosomal protein L19 MSMEG_2440 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 118467631 Common ftsZ cell division protein FtsZ MSMEG_4222 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 118468777 Common - hypothetical protein MSMEG_3252 76 COG1742 COG1742, Uncharacterized conserved protein Function unknown 118472109 Common - oxidoreductase, zinc-binding dehydrogenase family protein MSMEG_2564 124 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 118470363 Common - transcriptional regulator, LysR family protein MSMEG_6776 163 COG0583 LysR, Transcriptional regulator Transcription 118471972 Common - hypothetical protein MSMEG_0231 16 COG0011 COG0011, Uncharacterized conserved protein Function unknown 118473421 Common rpmJ 50S ribosomal protein L36 MSMEG_1520 132 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 118469175 Common - metal dependent hydrolase MSMEG_3427 90 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 118472835 Common - hypothetical protein MSMEG_2968 57 COG3665 COG3665, Uncharacterized conserved protein Function unknown 118468882 Common - peptide/opine/nickel uptake family protein ABC transporter, periplasmic substrate-binding protein, putative MSMEG_1084 211 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 118473820 Common - hypothetical protein MSMEG_2612 15 COG2267 PldB, Lysophospholipase Lipid metabolism 118470619 Common - hypothetical protein MSMEG_2634 98 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 118467761 Common - acetyl-coenzyme a carboxylase carboxyl transferase MSMEG_5642 221 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 118472899 Common - glucarate dehydratase MSMEG_6117 56 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 118471458 Pathogen - hypothetical protein MSMEG_2158 1 None None None 118469706 Pathogen - hypothetical protein MSMEG_5916 1 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 118469718 Common - [NiFe] hydrogenase, gamma subunit, putative MSMEG_3930 121 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 118471289 Common purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase MSMEG_5515 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 118467884 Pathogen - hypothetical protein MSMEG_4021 1 None None None 118471663 Common - transcriptional regulator, LysR family protein MSMEG_0708 189 COG0583 LysR, Transcriptional regulator Transcription 118470926 Pathogen - hypothetical protein MSMEG_1024 1 None None None 118473601 Common pyrC dihydroorotase MSMEG_3044 212 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 118469463 Common gmhA phosphoheptose isomerase MSMEG_2706 119 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 118473301 Pathogen - hypothetical protein MSMEG_6920 1 None None None 118471813 Common - shikimate transporter MSMEG_3386 167 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 118469307 Common - HpcH/HpaI aldolase MSMEG_1994 7 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 118469886 Common - hypothetical protein MSMEG_5264 5 None None None 118469345 Common - hypothetical protein MSMEG_2686 6 None None None 118469076 Common - transcriptional regulator, GntR family protein, putative MSMEG_2480 10 COG2186 FadR, Transcriptional regulators Transcription 118472329 Common - acyl-CoA dehydrogenase fadE12 MSMEG_5494 159 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118468770 Common - Low molecular weight phosphotyrosine protein phosphatase MSMEG_1171 136 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 118469043 Common - ABC transporter permease protein MSMEG_4387 219 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118469955 Common - putative FAD-binding dehydrogenase MSMEG_5835 29 COG3573 COG3573, Predicted oxidoreductase General function prediction only 118471020 Common - integral membrane protein MSMEG_0249 23 COG0628 PerM, Predicted permease General function prediction only 118468368 Common - Pyridine nucleotide-disulphide oxidoreductase MSMEG_1416 236 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 118471829 Common - Fe uptake system integral membrane protein MSMEG_6063 187 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 118468895 Common - transcriptional repressor, CopY family protein MSMEG_3630 33 COG3682 COG3682, Predicted transcriptional regulator Transcription 118467779 Pathogen - hypothetical protein MSMEG_4346 1 None None None 118472895 Common - hypothetical protein MSMEG_1680 39 COG3342 COG3342, Uncharacterized conserved protein Function unknown 118470284 Common - periplasmic binding proteins and sugar binding domain of the LacI family protein, putative MSMEG_4888 115 COG1609 PurR, Transcriptional regulators Transcription 118473770 Common - hypothetical protein MSMEG_0687 27 COG5438 COG5438, Predicted multitransmembrane protein Function unknown 118469330 Common - hypothetical protein MSMEG_3752 1 None None None 118467650 Common - hypothetical protein MSMEG_0071 1 COG5373 COG5373, Predicted membrane protein Function unknown 118470250 Common - RemM protein MSMEG_0986 10 None None None 118471858 Common - hypothetical protein MSMEG_3114 42 COG0434 SgcQ, Predicted TIM-barrel enzyme General function prediction only 118470770 Common - hypothetical protein MSMEG_3414 3 COG4129 COG4129, Predicted membrane protein Function unknown 118469720 Common - ABC transporter periplasmic-binding protein YphF MSMEG_3999 85 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118467645 Common - oxidoreductase FAD-binding region MSMEG_4411 142 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 118470868 Common nusA transcription elongation factor NusA MSMEG_2625 228 COG0195 NusA, Transcription elongation factor Transcription 118471131 Common - Condensation domain protein MSMEG_0409 10 None None None 118467600 Common - methyltransferase MSMEG_0095 31 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118469015 Common - aldehyde dehydrogenase, thermostable MSMEG_6687 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118473843 Common - transcriptional regulator, LysR family protein MSMEG_1678 182 COG0583 LysR, Transcriptional regulator Transcription 118468904 Common - TetR-family protein transcriptional regulator MSMEG_1700 24 COG1309 AcrR, Transcriptional regulator Transcription 118471702 Pathogen - hypothetical protein MSMEG_5952 2 None None None 118470146 Common cobN cobaltochelatase MSMEG_3864 89 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 118473163 Common - hypothetical protein MSMEG_0441 9 None None None 118471116 Common - chitooligosaccharide deacetylase MSMEG_5023 97 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 118470179 Common - aryl-alcohol dehydrogenase MSMEG_2034 173 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 118472260 Common gnd 6-phosphogluconate dehydrogenase MSMEG_3632 185 COG0362 Gnd, 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 118471709 Common - alcohol dehydrogenase MSMEG_6834 205 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 118467924 Common - hypothetical protein MSMEG_5766 1 None None None 118470781 Common - nitrile hydratase regulator1 MSMEG_5339 82 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 118468747 Common - glutamine amidotransferase MSMEG_4214 118 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 118468319 Pathogen - hypothetical protein MSMEG_6659 1 None None None 118472919 Common - NTP pyrophosphohydrolase MSMEG_6185 62 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 118473758 Common - transporter, small conductance mechanosensitive ion channel (MscS) family protein MSMEG_2087 84 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 118473578 Common - hypothetical protein MSMEG_1206 1 None None None 118473642 Common - hypothetical protein MSMEG_1871 5 COG4842 COG4842, Uncharacterized protein conserved in bacteria Function unknown 118472411 Common - MmcJ protein MSMEG_2162 3 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118468122 Common - enoyl-CoA hydratase/isomerase family protein MSMEG_1739 170 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118468468 Common - enoyl-CoA hydratase/isomerase MSMEG_2220 178 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118469548 Common - universal stress protein family protein MSMEG_5245 21 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 118471377 Common argC N-acetyl-gamma-glutamyl-phosphate reductase MSMEG_3776 213 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 118470519 Common - 3-hydroxyisobutyrate dehydrogenase family protein MSMEG_5884 136 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 118470171 Common - siderophore binding protein MSMEG_5191 187 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 118472293 Common murE UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase MSMEG_4232 212 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 118471091 Common - hypothetical protein MSMEG_4982 12 None None None 118473435 Common - DNA repair exonuclease MSMEG_5004 65 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 118471219 Common - amino acid permease-associated region MSMEG_6727 162 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118470507 Common - transcriptional regulator, ArsR family protein MSMEG_3372 35 COG0640 ArsR, Predicted transcriptional regulators Transcription 118470031 Common - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase MSMEG_3209 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 118471466 Common - aldehyde dehydrogenase (NAD) family protein MSMEG_3387 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118470100 Common - hypothetical protein MSMEG_0077 1 None None None 118469318 Common - probable transcriptional regulatory protein MSMEG_0092 36 COG1309 AcrR, Transcriptional regulator Transcription 118469873 Common - thioesterase superfamily protein MSMEG_0128 45 COG0824 FcbC, Predicted thioesterase General function prediction only 118470266 Common - hypothetical protein MSMEG_3591 1 None None None 118474019 Common folA dihydrofolate reductase MSMEG_2671 143 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 118469748 Pathogen - hypothetical protein MSMEG_3917 1 None None None 118472928 Common - hypothetical protein MSMEG_0352 6 None None None 118472612 Common - transcriptional regulator, MerR family protein MSMEG_3644 23 COG0789 SoxR, Predicted transcriptional regulators Transcription 118469711 Common - ABC transporter ATP-binding protein MSMEG_5660 248 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 118473284 Common - polyketide synthetase mbtd MSMEG_4512 97 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118468886 Common - oxygenase MSMEG_1499 128 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118469036 Common - transposase MSMEG_4550 85 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 118469918 Common - dehydrogenase/reductase SDR family protein member 4 MSMEG_5383 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118472730 Common - hypothetical protein MSMEG_2108 18 COG3687 COG3687, Predicted metal-dependent hydrolase General function prediction only 118468515 Common - polyamine ABC transporter permease protein MSMEG_3279 201 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 118468832 Common - putative acyl-CoA dehydrogenase MSMEG_4084 89 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118470446 Common - hypothetical protein MSMEG_1931 12 COG4445 MiaE, Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 118472719 Common - peptidase S9, prolyl oligopeptidase MSMEG_4719 139 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 118472036 Common - esterase MSMEG_5271 120 COG0657 Aes, Esterase/lipase Lipid metabolism 118472858 Common - methyltransferase small domain superfamily protein MSMEG_4544 14 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 118467434 Pathogen - hypothetical protein MSMEG_4677 1 None None None 118469904 Common - transcriptional regulator, GntR family protein MSMEG_0426 160 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 118471480 Common - acyl-CoA dehydrogenase MSMEG_1904 136 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118471430 Common - bacterial extracellular solute-binding protein, family protein 7 MSMEG_3348 102 COG1638 DctP, TRAP-type C4-dicarboxylate transport system, periplasmic component Carbohydrate transport and metabolism 118472505 Common - ISMsm2, transposase MSMEG_0054 52 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 118470106 Common - transporter permease 1 MSMEG_2460 180 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 118468099 Common - estradiol 17-beta-dehydrogenase 8 MSMEG_3112 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118468635 Common - hypothetical protein MSMEG_4540 24 COG4552 Eis, Predicted acetyltransferase involved in intracellular survival and related acetyltransferases General function prediction only 118467352 Common - carveol dehydrogenase MSMEG_4849 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471283 Common - Transcription factor WhiB MSMEG_1597 16 None None None 118471006 Common nhaA Na+/H+ antiporter NhaA MSMEG_2775 105 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 118468606 Pathogen - probable membrane protein MSMEG_0583 1 None None None 118471328 Common - tagatose-1,6-bisphosphate aldolase GatY MSMEG_0898 166 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 118468473 Common - acyl-CoA dehydrogenase, C- domain protein MSMEG_2077 45 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473744 Common wrbA NAD(P)H:quinone oxidoreductase, type IV MSMEG_2375 108 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 118470305 Common - putative oxidoreductase MSMEG_1291 123 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 118467553 Common - TnpC protein MSMEG_1310 9 None None None 118469526 Pathogen - hypothetical protein MSMEG_1273 1 None None None 118472197 Common cobO cob(I)yrinic acid a,c-diamide adenosyltransferase MSMEG_2616 141 COG2109 BtuR, ATP:corrinoid adenosyltransferase Coenzyme metabolism 118467799 Common gap glyceraldehyde-3-phosphate dehydrogenase, type I MSMEG_3084 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 118471451 Common rhaD short chain dehydrogenase MSMEG_0590 236 COG3347 COG3347, Uncharacterized conserved protein Function unknown 118473889 Pathogen - hypothetical protein MSMEG_1089 1 None None None 118468799 Common - MmcI protein MSMEG_6907 39 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118472889 Common - transcriptional regulator LacI family protein MSMEG_6376 129 COG1609 PurR, Transcriptional regulators Transcription 118468476 Common - thiamin pyrophosphokinase, catalytic domain protein MSMEG_3748 19 COG4825 COG4825, Uncharacterized membrane-anchored protein conserved in bacteria Function unknown 118471311 Common pcaC 4-carboxymuconolactone decarboxylase MSMEG_6370 81 COG2128 COG2128, Uncharacterized conserved protein Function unknown 118467750 Common - hypothetical protein MSMEG_3764 15 COG2835 COG2835, Uncharacterized conserved protein Function unknown 118469840 Common - nudix hydrolase MSMEG_6617 39 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 118471084 Common - putative pyrimidine permease RutG MSMEG_0810 118 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 118472286 Pathogen - hypothetical protein MSMEG_3920 1 None None None 118472704 Common - acetyltransferase MSMEG_0356 40 COG2388 COG2388, Predicted acetyltransferase General function prediction only 118472430 Common - 56kDa selenium binding protein MSMEG_2094 18 None None None 118470512 Common - hypothetical protein MSMEG_0060 8 None None None 118472095 Common - haloalkane dehalogenase MSMEG_6837 71 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118469417 Common - hypothetical protein MSMEG_2127 77 COG3189 COG3189, Uncharacterized conserved protein Function unknown 118469962 Common - hypothetical protein MSMEG_5704 4 None None None 118469496 Common - fatty acid desaturase MSMEG_5773 11 None None None 118472302 Common - glucose-methanol-choline oxidoreductase MSMEG_5967 67 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 118468357 Common - ArsR-family protein transcriptional regulator MSMEG_2606 57 COG0640 ArsR, Predicted transcriptional regulators Transcription 118469212 Common - translation initiation inhibitor MSMEG_4061 76 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 118472517 Common - biotin-[acetyl-CoA-carboxylase] ligase MSMEG_1822 219 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 118468196 Common - TrkA protein MSMEG_2771 92 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 118467770 Common - extracellular deoxyribonuclease MSMEG_2404 24 COG3513 COG3513, Uncharacterized protein conserved in bacteria Function unknown 118473428 Common - probable conserved transmembrane protein MSMEG_3946 4 None None None 118470962 Common hydA dihydropyrimidinase MSMEG_4012 194 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 118468403 Common - two-component system response regulator MSMEG_6128 218 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118471736 Common - bacterial membrane flanked domain family protein MSMEG_0865 14 COG3428 COG3428, Predicted membrane protein Function unknown 118472720 Common - hypothetical protein MSMEG_5499 1 None None None 118470439 Common - hypothetical protein MSMEG_4841 4 None None None 118471337 Common - hypothetical protein MSMEG_2840 26 COG0398 COG0398, Uncharacterized conserved protein Function unknown 118472355 Common - binding-protein-dependent transport systems inner membrane component MSMEG_3109 175 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 118469242 Common speB agmatinase MSMEG_1072 160 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 118471332 Pathogen - hypothetical protein MSMEG_3732 1 None None None 118472278 Common - lipoprotein YaeC, putative MSMEG_5809 100 COG1464 NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen Inorganic ion transport and metabolism 118470422 Common - lipoprotein MSMEG_6064 76 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 118469365 Common corA magnesium and cobalt transport protein CorA MSMEG_5056 170 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 118472955 Common - transmembrane protein MSMEG_2946 4 COG3759 COG3759, Predicted membrane protein Function unknown 118473265 Common - cytochrome p450 MSMEG_4823 79 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118473697 Common - glycosyl transferase, family protein 2 MSMEG_0995 170 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 118467993 Common - hypothetical protein MSMEG_6432 5 None None None 118473112 Common - FAD dependent oxidoreductase MSMEG_0670 99 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 118468704 Common - hypothetical protein MSMEG_4701 19 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 118469209 Common - putative DNA-binding protein MSMEG_5679 54 COG0640 ArsR, Predicted transcriptional regulators Transcription 118467697 Common serB phosphoserine phosphatase MSMEG_2321 157 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 118471572 Common - oxidoreductase molybdopterin binding domain, putative MSMEG_6457 5 None None None 118468761 Pathogen - hypothetical protein MSMEG_3182 1 None None None 118473095 Common - alcohol dehydrogenase 1 MSMEG_1138 209 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 118468675 Common - globin MSMEG_5765 27 COG2346 COG2346, Truncated hemoglobins General function prediction only 118469322 Common - ABC transporter ATP-binding protein MSMEG_4761 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 118470801 Common - ATPase, AAA family protein MSMEG_3902 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 118468956 Common - ion-transporting ATPase MSMEG_6195 25 COG0003 ArsA, Predicted ATPase involved in chromosome partitioning Cell division and chromosome partitioning 118472791 Common - coniferyl aldehyde dehydrogenase MSMEG_2242 210 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118469346 Common - acyl-CoA dehydrogenase MSMEG_4715 167 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472594 Common uvrB excinuclease ABC subunit B MSMEG_3816 224 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 118470156 Common - integral membrane protein MSMEG_2178 9 COG3059 COG3059, Predicted membrane protein Function unknown 118468542 Common - phytoene synthase MSMEG_2346 79 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 118471350 Common hemH ferrochelatase MSMEG_3152 74 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 118474010 Common - hypothetical oxidoreductase MSMEG_5857 170 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 118467368 Common - ABC transporter, permease/ATP-binding protein MSMEG_3656 249 COG4178 COG4178, ABC-type uncharacterized transport system, permease and ATPase components General function prediction only 118472965 Common - Phosphotransferase enzyme family protein MSMEG_6337 58 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 118473646 Common - integral membrane protein MSMEG_0697 7 None None None 118470940 Common - 3-oxoacyl-(acyl-carrier-protein) reductase, putative MSMEG_4800 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470038 Common - transcriptional regulator, LysR family protein MSMEG_4025 182 COG0583 LysR, Transcriptional regulator Transcription 118473419 Common - kumamolisin MSMEG_1617 27 COG4934 COG4934, Predicted protease Posttranslational modification, protein turnover, chaperones 118468410 Common - hypothetical protein MSMEG_5763 39 None None None 118472905 Common - alpha/beta hydrolase fold MSMEG_1576 144 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118470190 Common - putative transcriptional regulator MSMEG_2260 43 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 118470332 Common - glyoxalase family protein MSMEG_0608 46 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 118467805 Common - oxidoreductase, zinc-binding dehydrogenase family protein MSMEG_0097 189 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118471677 Common - capreomycidine hydroxylase MSMEG_4372 76 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 118473223 Common - transporter, major facilitator family protein MSMEG_5347 100 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118472973 Common - GntR family protein transcriptional regulator MSMEG_2531 127 COG1802 GntR, Transcriptional regulators Transcription 118470882 Common - immunogenic protein MPB64/MPT64 MSMEG_1051 1 None None None 118467962 Common - possible transcriptional regulatory protein MSMEG_4338 100 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118472662 Common - ribonuclease, putative MSMEG_1658 69 COG1295 Rbn, Predicted membrane protein Function unknown 118469827 Common - sulfate/thiosulfate import ATP-binding protein CysA MSMEG_4520 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 118469256 Common - integral membrane transport protein MSMEG_1169 46 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118471627 Common - hypothetical protein MSMEG_0354 1 None None None 118471587 Common rimI ribosomal-protein-alanine acetyltransferase MSMEG_1579 182 COG0456 RimI, Acetyltransferases General function prediction only 118470730 Common - septum formation initiator subfamily protein, putative MSMEG_5414 26 COG1507 COG1507, Uncharacterized conserved protein Function unknown 118473606 Pathogen pqqA coenzyme PQQ biosynthesis protein A MSMEG_3725 1 None None None 118467788 Pathogen - hypothetical protein MSMEG_4591 1 None None None 118470231 Common gvpK gas vesicle protein K MSMEG_5744 18 None None None 118470569 Common - AP endonuclease, family protein 2 MSMEG_6715 25 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 118471217 Common - Rieske [2Fe-2S] domain protein MSMEG_1459 62 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 118471032 Common - N-carbamoyl-L-amino acid amidohydrolase MSMEG_4014 84 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 118469950 Common - trehalose 6-phosphate phosphorylase MSMEG_3954 50 COG1554 ATH1, Trehalose and maltose hydrolases (possible phosphorylases) Carbohydrate transport and metabolism 118468435 Common - cytochrome P450 107B1 MSMEG_6312 93 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118471923 Common - hypothetical protein MSMEG_3905 13 COG1550 COG1550, Uncharacterized protein conserved in bacteria Function unknown 118470330 Common - cobalamin biosynthesis protein cobIJ MSMEG_3873 160 COG1010 CobJ, Precorrin-3B methylase Coenzyme metabolism 118473680 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen MSMEG_4320 187 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 118471233 Common - dicarboxylate-carrier protein MSMEG_2172 20 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 118473140 Common - universal stress protein family protein MSMEG_5733 42 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 118471445 Common arsC arsenate reductase MSMEG_5428 115 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 118470238 Common - transcriptional regulator, TetR family protein MSMEG_5860 3 COG1309 AcrR, Transcriptional regulator Transcription 118468372 Common - glyoxalase/bleomycin resistance protein/dioxygenase MSMEG_3958 20 None None None 118474039 Common - maleylacetate reductase MSMEG_6712 144 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 118472249 Common - HNH endonuclease MSMEG_0144 6 COG5373 COG5373, Predicted membrane protein Function unknown 118468005 Common - dihydrokaempferol 4-reductase MSMEG_6563 100 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118467836 Common - peptidase M22, glycoprotease MSMEG_1578 173 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 118469655 Common - MerR-family protein transcriptional regulator MSMEG_2194 127 COG0789 SoxR, Predicted transcriptional regulators Transcription 118469311 Common - LpqT protein MSMEG_5429 1 None None None 118473827 Common - YbaK/prolyl-tRNA synthetase associated region MSMEG_5671 63 COG2606 EbsC, Uncharacterized conserved protein Function unknown 118471489 Common - transcriptional regulator, MerR family protein MSMEG_2017 14 COG3585 MopI, Molybdopterin-binding protein Coenzyme metabolism 118469928 Common - hypothetical protein MSMEG_2350 153 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 118473295 Common - transposase IstA protein, putative MSMEG_1857 51 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 118469731 Common - DNA-binding protein MSMEG_6729 41 COG1396 HipB, Predicted transcriptional regulators Transcription 118470825 Common - hypothetical protein MSMEG_6112 24 COG5282 COG5282, Uncharacterized conserved protein Function unknown 118467940 Common - AMP-dependent synthetase and ligase MSMEG_5631 221 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118471253 Common - aldehyde dehydrogenase (NAD) family protein MSMEG_5859 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118469170 Common - GTP cyclohydrolase II MSMEG_1038 26 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 118469666 Common - ribonucleotide-diphosphate reductase subunit alpha MSMEG_1019 218 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 118473009 Common - cytochrome P450 51 MSMEG_5863 81 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118471399 Pathogen - intersectin-EH binding protein Ibp1 MSMEG_5887 1 None None None 118473519 Common - thiocyanate hydrolase beta subunit MSMEG_6266 12 None None None 118471635 Common - rhodanese domain protein/cystathionine beta-lyase MSMEG_4589 21 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 118472304 Common - CinZ protein MSMEG_0461 133 COG1739 COG1739, Uncharacterized conserved protein Function unknown 118467609 Common - transporter, major facilitator family protein MSMEG_0818 140 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118468689 Common - palmitoyl-CoA hydrolase MSMEG_6208 77 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 118470006 Common - hypothetical protein MSMEG_6778 1 None None None 118473431 Common - tetratricopeptide repeat family protein MSMEG_3802 1 None None None 118468594 Common - transcriptional regulator, TetR family protein MSMEG_5597 96 COG1309 AcrR, Transcriptional regulator Transcription 118470644 Common - myo-inositol-1-phosphate synthase MSMEG_6904 56 COG1260 INO1, Myo-inositol-1-phosphate synthase Lipid metabolism 118471831 Common - short chain dehydrogenase MSMEG_3879 78 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118473483 Common - short chain dehydrogenase MSMEG_4330 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118469597 Common - acyl-CoA dehydrogenase MSMEG_3783 158 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118469132 Pathogen - hypothetical protein MSMEG_1104 1 None None None 118472445 Common - histone deacetylase superfamily protein MSMEG_0171 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 118473706 Common - TetR-family protein transcriptional regulator MSMEG_0343 64 COG1309 AcrR, Transcriptional regulator Transcription 118473541 Common - BadF/BadG/BcrA/BcrD ATPase family protein MSMEG_0191 4 COG2971 COG2971, Predicted N-acetylglucosamine kinase Carbohydrate transport and metabolism 118472684 Common - hypothetical protein MSMEG_3330 10 None None None 118473478 Common - peptidase M52, hydrogen uptake protein MSMEG_2264 65 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 118473510 Common - caib/baif family protein MSMEG_4851 114 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118473623 Common - hypothetical protein MSMEG_5691 18 None None None 118469290 Common - O-methyltransferase MdmC MSMEG_0224 113 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 118471764 Common - hypothetical protein MSMEG_3120 14 None None None 118469800 Common - transcriptional regulator, TetR family protein MSMEG_0656 13 COG3226 COG3226, Uncharacterized protein conserved in bacteria Function unknown 118473234 Common - oligoribonuclease MSMEG_4724 88 COG1949 Orn, Oligoribonuclease (3'->5' exoribonuclease) RNA processing and modification 118470206 Common - P-type ATPase - metal cation transport MSMEG_5636 232 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 118473021 Common - acyl-CoA synthetase MSMEG_4772 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118469341 Common bluB cob(II)yrinic acid a,c-diamide reductase MSMEG_6053 112 COG0778 NfnB, Nitroreductase Energy production and conversion 118470015 Common - hypothetical protein MSMEG_6863 96 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 118468682 Common - putative oxidoreductase MSMEG_6264 94 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 118473472 Common - D-amino-acid dehydrogenase MSMEG_1129 116 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 118469773 Common tal transaldolase MSMEG_4415 62 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 118473492 Common - putative diol dehydratase reactivation protein MSMEG_6318 12 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 118468662 Common rpe ribulose-phosphate 3-epimerase MSMEG_3066 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 118469738 Common - oxidoreductase MSMEG_4023 230 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 118472563 Common - hypothetical protein MSMEG_2679 60 COG3214 COG3214, Uncharacterized protein conserved in bacteria Function unknown 118471580 Common - putative monovalent cation/H+ antiporter subunit E MSMEG_0845 37 COG1863 MnhE, Multisubunit Na+/H+ antiporter, MnhE subunit Inorganic ion transport and metabolism 118473232 Common - hypothetical protein MSMEG_1135 1 None None None 118470808 Common - hypothetical protein MSMEG_2256 41 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118469811 Common - putative acyl-CoA dehydrogenase MSMEG_6012 152 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473354 Common - hypothetical protein MSMEG_5105 4 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 118468052 Common - secreted protein MSMEG_1313 38 None None None 118467388 Common - Carboxyl transferase domain protein MSMEG_4717 143 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 118467343 Common - LppL protein MSMEG_4196 5 None None None 118470550 Common - putative acyl-CoA dehydrogenase MSMEG_0102 147 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473658 Common - alcohol dehydrogenase, zinc-containing MSMEG_0303 195 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118470267 Common mutM formamidopyrimidine-DNA glycosylase MSMEG_2419 177 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 118467379 Common ribE riboflavin synthase subunit alpha MSMEG_3071 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 118467908 Common - cadmium transporting P-type ATPase MSMEG_6058 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 118467429 Common - oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_5632 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118467906 Common - ISMsm1, transposase orfB MSMEG_2818 140 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 118471876 Common - transporter, major facilitator family protein MSMEG_6375 76 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118473637 Common priA primosome assembly protein PriA MSMEG_3061 185 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 118467699 Pathogen - hypothetical protein MSMEG_4369 1 None None None 118469563 Common - CDP-diacylglycerol-glycerol-3-phosphate MSMEG_3652 118 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 118470652 Common - IS1096, tnpR protein MSMEG_6162 44 None None None 118469021 Common - Rmt3 protein MSMEG_0391 13 None None None 118470012 Common - glycerol dehydratase large subunit MSMEG_0497 13 COG4909 PduC, Propanediol dehydratase, large subunit Secondary metabolites biosynthesis, transport, and catabolism 118469164 Common - transcriptional regulator, ArsR family protein MSMEG_4175 87 COG0640 ArsR, Predicted transcriptional regulators Transcription 118473945 Common - hypothetical protein MSMEG_6431 7 None None None 118468869 Common - short-chain dehydrogenase/reductase SDR MSMEG_2808 235 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118468039 Common - DNA or RNA helicase of superfamily protein II MSMEG_5706 73 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 118469501 Common - serine/threonine-protein kinase PknD MSMEG_4366 153 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 118473887 Common fabG 3-oxoacyl-(acyl-carrier-protein) reductase MSMEG_0294 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471600 Common metH B12-dependent methionine synthase MSMEG_4185 179 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 118473933 Common deoC deoxyribose-phosphate aldolase MSMEG_3089 135 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 118468808 Common - hypothetical protein MSMEG_3645 76 COG1259 COG1259, Uncharacterized conserved protein Function unknown 118469191 Common - TetR-family protein transcriptional regulator MSMEG_5307 8 COG1309 AcrR, Transcriptional regulator Transcription 118469253 Common - membrane protein MSMEG_0750 163 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 118468066 Common - cupin domain protein MSMEG_0644 11 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 118468701 Common - beta-lactamase MSMEG_0610 77 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 118471373 Common - ABC-2 type transporter superfamily protein MSMEG_6765 44 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 118468639 Common - TetR-family protein transcriptional regulator MSMEG_4033 31 COG1309 AcrR, Transcriptional regulator Transcription 118473600 Common - hypothetical protein MSMEG_4197 8 None None None 118472645 Common - AP endonuclease, family protein 2 MSMEG_4651 61 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 118471538 Common - AraC family protein transcriptional regulator MSMEG_5911 17 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 118467922 Pathogen - hypothetical protein MSMEG_3258 1 None None None 118470536 Common - alpha/beta hydrolase MSMEG_6850 98 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118469577 Common - hypothetical protein MSMEG_2873 52 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 118471563 Pathogen - hypothetical protein MSMEG_5557 2 None None None 118470520 Pathogen - hypothetical protein MSMEG_1201 1 None None None 118469522 Common bioD dithiobiotin synthetase MSMEG_3190 10 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 118468988 Common trpA tryptophan synthase subunit alpha MSMEG_3221 218 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 118471717 Common - transporter, monovalent cation:proton antiporter-2 (CPA2) family protein MSMEG_6769 105 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 118468289 Common - polyphosphate kinase 2 MSMEG_0891 127 COG2326 COG2326, Uncharacterized conserved protein Function unknown 118470585 Common - ABC transporter component A MSMEG_1159 30 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 118469200 Common - Citrate transporter MSMEG_1453 14 None None None 118472725 Common purA adenylosuccinate synthetase MSMEG_0759 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 118469064 Common rpmE ribosomal protein L31 MSMEG_4951 200 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 118472775 Common - hypothetical protein MSMEG_5873 2 None None None 118469553 Common - hypothetical protein MSMEG_1281 31 COG4913 COG4913, Uncharacterized protein conserved in bacteria Function unknown 118470584 Common - transcriptional regulator, TetR family protein MSMEG_0859 10 COG1309 AcrR, Transcriptional regulator Transcription 118468244 Common - acyl-CoA dehydrogenase domain protein MSMEG_5619 144 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118467843 Common - thioesterase MSMEG_1433 16 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 118473320 Common ispH 4-hydroxy-3-methylbut-2-enyl diphosphate reductase MSMEG_5224 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 118467990 Common - antibiotic biosynthesis monooxygenase domain protein MSMEG_2688 20 COG1359 COG1359, Uncharacterized conserved protein Function unknown 118468992 Pathogen - hypothetical protein MSMEG_1212 1 None None None 118468046 Common - probable serine/threonine-protein kinase PknH, putative MSMEG_4595 1 None None None 118473550 Common - phosphohydrolase MSMEG_3679 20 COG4119 COG4119, Predicted NTP pyrophosphohydrolase DNA replication, recombination, and repair / General function prediction only 118469771 Common - putative non-ribosomal peptide synthetase MSMEG_4515 210 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118470340 Common - ABC nitrate/sulfonate/bicarbonate family protein transporter, inner membrane subunit, putative MSMEG_6494 154 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 118469080 Common - xylose transport system permease protein XylH MSMEG_1706 107 COG4214 XylH, ABC-type xylose transport system, permease component Carbohydrate transport and metabolism 118472825 Common - hydantoin racemase MSMEG_5729 45 COG4126 COG4126, Hydantoin racemase Amino acid transport and metabolism 118468913 Common - hypothetical protein MSMEG_4822 34 COG1141 Fer, Ferredoxin Energy production and conversion 118470002 Common - hypothetical protein MSMEG_4191 18 None None None 118468389 Common - phosphoglycerate mutase family protein, putative MSMEG_6338 50 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 118472991 Common - hypothetical protein MSMEG_5342 5 None None None 118472181 Common - ABC transporter ATP-binding protein MSMEG_0795 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 118470228 Common - hypothetical protein MSMEG_4735 5 None None None 118473671 Common moaA molybdenum cofactor biosynthesis protein A MSMEG_5698 194 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 118471934 Common - hypothetical protein MSMEG_0805 1 None None None 118473992 Pathogen - hypothetical protein MSMEG_3443 1 None None None 118469046 Common - hypothetical protein MSMEG_5715 104 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118468055 Common - lipoprotein, putative MSMEG_1395 2 None None None 118468837 Common - dgpf domain family protein MSMEG_1349 29 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 118471172 Common - 3-oxoacyl-(acyl carrier protein) synthase II MSMEG_4327 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118471186 Common - major facilitator family protein transporter MSMEG_3586 137 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118473209 Common hisE phosphoribosyl-ATP pyrophosphatase MSMEG_4181 44 COG0140 HisI, Phosphoribosyl-ATP pyrophosphohydrolase Amino acid transport and metabolism 118470603 Common amt ammonium transporter MSMEG_2425 201 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 118470401 Common - hypothetical protein MSMEG_4970 1 None None None 118473570 Pathogen - hypothetical protein MSMEG_3921 1 None None None 118468045 Common - transcriptional regulator, LysR family protein MSMEG_6677 170 COG0583 LysR, Transcriptional regulator Transcription 118473390 Common - allantoate amidohydrolase MSMEG_1180 84 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 118470844 Common - acetyl-coenzyme A synthetase MSMEG_3986 222 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 118473273 Common - NikQ protein MSMEG_5846 66 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118471640 Common - hydrolase MSMEG_3336 146 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118469910 Common - hypothetical protein MSMEG_0855 7 None None None 118473407 Common - virulence factor Mce family protein, putative MSMEG_0136 17 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118471531 Common - transcriptional regulator, MerR family protein MSMEG_3180 133 COG0789 SoxR, Predicted transcriptional regulators Transcription 118472568 Common - hypothetical protein MSMEG_3569 7 None None None 118473128 Common rplJ 50S ribosomal protein L10 MSMEG_1364 200 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 118467473 Common - dehydrogenase MSMEG_6818 190 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 118472367 Pathogen - PduH protein MSMEG_1550 1 None None None 118470680 Common hpt hypoxanthine phosphoribosyltransferase MSMEG_6110 140 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 118467935 Common - hypothetical protein MSMEG_0558 2 None None None 118471264 Common - N-methylhydantoinase MSMEG_3973 94 COG0146 HyuB, N-methylhydantoinase B/acetone carboxylase, alpha subunit Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118469605 Common - transcriptional regulatory protein MSMEG_6546 68 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 118471898 Common - carboxymethylenebutenolidase MSMEG_3558 108 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 118471171 Pathogen - hypothetical protein MSMEG_4536 1 None None None 118470483 Common - hypothetical protein MSMEG_6772 127 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 118470498 Common - inositol-1-monophosphatase MSMEG_2762 181 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 118472395 Common - proline dipeptidase MSMEG_3881 232 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 118473215 Common - ABC transporter permease protein MSMEG_4764 183 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 118473121 Common - ABC transporter ATP-binding protein MSMEG_5075 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 118472437 Common - hypothetical protein MSMEG_5225 4 None None None 118473067 Common - putative transcriptional regulator MSMEG_1168 5 COG1309 AcrR, Transcriptional regulator Transcription 118472457 Common - putative thiosulfate sulfurtransferase MSMEG_1809 144 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 118471609 Common rpsN 30S ribosomal protein S14 MSMEG_6066 199 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 118467876 Common - transposase MSMEG_6889 33 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 118470689 Common - aldose 1-epimerase subfamily protein MSMEG_0717 13 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 118467441 Common - beta-lactamase related protein MSMEG_6194 8 COG2367 PenP, Beta-lactamase class A Defense mechanisms 118470990 Pathogen - hypothetical protein MSMEG_6228 1 None None None 118473668 Pathogen - hypothetical protein MSMEG_4634 1 None None None 118470416 Common - hypothetical protein MSMEG_0559 180 COG1278 CspC, Cold shock proteins Transcription 118470087 Common cysE serine O-acetyltransferase MSMEG_5947 114 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 118472344 Common - hypothetical protein MSMEG_0948 24 COG2030 MaoC, Acyl dehydratase Lipid metabolism 118472360 Pathogen - hypothetical protein MSMEG_2751 1 None None None 118467588 Common lon ATP-dependent protease La MSMEG_3582 208 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 118468572 Common - sorbitol dehydrogenase MSMEG_3605 212 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 118473568 Common sodC copper/zinc superoxide dismutase MSMEG_0835 65 COG2032 SodC, Cu/Zn superoxide dismutase Inorganic ion transport and metabolism 118468314 Common - hypothetical protein MSMEG_6328 7 None None None 118468695 Common - integral membrane transport protein MSMEG_5464 40 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118472579 Common - ABC nitrate/sulfonate/bicarbonate family protein transporter, inner membrane subunit MSMEG_4588 177 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 118468425 Common - short chain dehydrogenase MSMEG_5862 220 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118468506 Common - two component transcriptional regulatory protein devr MSMEG_3944 203 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118473282 Common - transcriptional regulator MSMEG_6828 46 COG3899 COG3899, Predicted ATPase General function prediction only 118474050 Common - amidohydrolase MSMEG_4842 84 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 118470763 Common - alpha/beta hydrolase fold MSMEG_5652 27 COG2267 PldB, Lysophospholipase Lipid metabolism 118468652 Common - transcriptional regulator, XRE family protein MSMEG_3525 32 COG1709 COG1709, Predicted transcriptional regulator Transcription 118470119 Common - alpha/beta hydrolase fold MSMEG_2777 105 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118471681 Common - hypothetical protein MSMEG_0420 3 None None None 118467982 Pathogen - hypothetical protein MSMEG_6435 1 None None None 118471223 Common - cytochrome p450 MSMEG_1009 92 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118473061 Pathogen - hypothetical protein MSMEG_1421 1 None None None 118469624 Common - IS1096, tnpR protein MSMEG_1405 44 None None None 118473142 Common - inositol-5-monophosphate dehydrogenase MSMEG_1603 220 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 118471346 Common dapF diaminopimelate epimerase MSMEG_2735 173 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 118470543 Common - IS1096, tnpR protein MSMEG_3696 44 None None None 118470034 Common - hypothetical protein MSMEG_6531 3 None None None 118469138 Pathogen - hypothetical protein MSMEG_0123 1 None None None 118468630 Common - acyl-CoA dehydrogenase family protein MSMEG_4592 137 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118469444 Common - dihydroxy-acid dehydratase MSMEG_0482 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 118474046 Common - IS1096, tnpR protein MSMEG_5379 44 None None None 118472486 Common - universal stress protein family protein MSMEG_1624 7 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 118470129 Common - TetR family protein transcriptional repressor LfrR MSMEG_6223 3 COG1309 AcrR, Transcriptional regulator Transcription 118467380 Common accD acetyl-CoA carboxylase, carboxyl transferase, beta subunit MSMEG_2169 198 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 118471897 Pathogen - hypothetical protein MSMEG_3342 1 None None None 118470676 Common nusB transcription antitermination protein NusB MSMEG_3036 78 COG0781 NusB, Transcription termination factor Transcription 118467491 Common - glucosamine--fructose-6-phosphate aminotransferase (isomerizing) MSMEG_0474 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 118469935 Common - hypothetical protein MSMEG_4234 3 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 118470247 Common - transcriptional regulator, TetR family protein MSMEG_2071 69 COG1309 AcrR, Transcriptional regulator Transcription 118467811 Common gyrA DNA gyrase subunit A MSMEG_0006 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 118473746 Common - oxidoreductase alpha (molybdopterin) subunit MSMEG_4668 175 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 118473417 Pathogen - hypothetical protein MSMEG_3340 1 None None None 118470406 Common - major facilitator family protein transporter MSMEG_5713 50 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118470999 Common - cationic amino acid transporter MSMEG_1838 175 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118468708 Common - secreted protein MSMEG_4529 49 COG2138 COG2138, Uncharacterized conserved protein Function unknown 118471991 Pathogen - hypothetical protein MSMEG_3441 1 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 118468393 Common - isochorismatase hydrolase MSMEG_4379 122 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 118472978 Common - hypothetical protein MSMEG_1872 2 COG4842 COG4842, Uncharacterized protein conserved in bacteria Function unknown 118473866 Pathogen - hypothetical protein MSMEG_4678 1 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 118472735 Common atzF allophanate hydrolase MSMEG_2189 218 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 118470894 Common - TetR-family protein transcriptional regulator MSMEG_2305 26 COG1309 AcrR, Transcriptional regulator Transcription 118470041 Common - 5,10-methylenetetrahydromethanopterin reductase MSMEG_2456 45 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118470213 Common - hypothetical protein MSMEG_5560 3 None None None 118467584 Common - cystathionine gamma-synthase MSMEG_5265 209 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 118470009 Common - short chain dehydrogenase MSMEG_1623 214 COG3320 COG3320, Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 118473331 Common - hypothetical protein MSMEG_4804 1 None None None 118473202 Pathogen - hypothetical protein MSMEG_3820 1 None None None 118473314 Common - short chain dehydrogenase MSMEG_5858 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471416 Common - CTP pyrophosphohydrolase MSMEG_5148 159 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 118471472 Pathogen - hypothetical protein MSMEG_6377 1 None None None 118470257 Common - amino acid transporter MSMEG_2680 60 COG0833 LysP, Amino acid transporters Amino acid transport and metabolism 118469638 Common - transcriptional regulator, TetR family protein MSMEG_1506 18 COG3226 COG3226, Uncharacterized protein conserved in bacteria Function unknown 118469594 Common selD selenide, water dikinase MSMEG_1852 99 COG0709 SelD, Selenophosphate synthase Amino acid transport and metabolism 118467372 Pathogen - hypothetical protein MSMEG_1122 1 None None None 118470019 Pathogen - hypothetical protein MSMEG_4797 1 None None None 118472121 Common - peptidase M23B MSMEG_2518 63 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 118470758 Common - short-chain dehydrogenase/reductase SDR MSMEG_2019 236 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118470969 Common - allophanate hydrolase subunit 1 MSMEG_0436 100 COG2049 DUR1, Allophanate hydrolase subunit 1 Amino acid transport and metabolism 118468734 Common - hypothetical protein MSMEG_0901 41 COG3564 COG3564, Uncharacterized protein conserved in bacteria Function unknown 118467901 Common - hydroxydechloroatrazine ethylaminohydrolase MSMEG_1297 176 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 118470299 Common - hypothetical protein MSMEG_2998 7 None None None 118473836 Common - cyclododecanone monooxygenase MSMEG_5625 50 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118469542 Pathogen - hypothetical protein MSMEG_5804 2 None None None 118468897 Common - transcriptional regulator, AsnC family protein MSMEG_1185 57 COG1522 Lrp, Transcriptional regulators Transcription 118467616 Common - Putative neutral zinc metallopeptidase MSMEG_4893 18 COG2321 COG2321, Predicted metalloprotease General function prediction only 118471726 Common - MaoC like domain protein MSMEG_6754 36 COG2030 MaoC, Acyl dehydratase Lipid metabolism 118467596 Common - agmatine deiminase MSMEG_0444 87 COG2957 COG2957, Peptidylarginine deiminase and related enzymes Amino acid transport and metabolism 118470256 Common - hydroxypyruvate isomerase, putative MSMEG_5478 73 COG3622 Hfi, Hydroxypyruvate isomerase Carbohydrate transport and metabolism 118468690 Common - Glycosyl hydrolase family protein 3 MSMEG_0361 167 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 118473028 Common - hypothetical protein MSMEG_4282 8 None None None 118468714 Common - putative serine-threonine protein kinase MSMEG_2410 21 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 118471526 Common - NAD dependent epimerase/dehydratase family protein MSMEG_4034 13 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118469056 Common - dTDP-4-dehydrorhamnose 3,5-epimerase MSMEG_1510 161 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 118469327 Common - GntR-family protein transcriptional regulator MSMEG_4659 131 COG2188 PhnF, Transcriptional regulators Transcription 118468906 Common - hypothetical glycosyl transferase MSMEG_0385 41 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 118473507 Common - hypothetical protein MSMEG_0758 5 None None None 118467862 Common - formamidase MSMEG_4367 61 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 118472138 Common - pe family protein MSMEG_5455 1 None None None 118471047 Common - D-alanyl-D-alanine carboxypeptidase MSMEG_1661 147 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 118469277 Pathogen - hypothetical protein MSMEG_1949 1 None None None 118471710 Common - hypothetical protein MSMEG_6750 1 None None None 118472803 Pathogen - hypothetical protein MSMEG_6397 1 None None None 118473611 Common - large subunit of N,N-dimethylformamidase MSMEG_1080 10 None None None 118469452 Common - rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_0121 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118469335 Pathogen - hypothetical protein MSMEG_0879 1 None None None 118467643 Pathogen - hypothetical protein MSMEG_5905 1 None None None 118470345 Common - ribonucleotide-diphosphate reductase subunit beta MSMEG_0358 19 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 118469582 Common - tetrahydropicolinate succinylase MSMEG_5104 35 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 118470428 Common - FadD16 protein MSMEG_3566 1 None None None 118473345 Common pgm phosphoglucomutase MSMEG_2136 213 COG0033 Pgm, Phosphoglucomutase Carbohydrate transport and metabolism 118469923 Pathogen - hypothetical protein MSMEG_5599 1 None None None 118467683 Common - hypothetical protein MSMEG_5260 3 None None None 118470861 Common - oxidoreductase MSMEG_6859 232 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118471712 Common - biphenyl-2,3-diol 1,2-dioxygenase MSMEG_6036 26 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 118472525 Common - molybdopterin biosynthesis protein MoeA 1 MSMEG_5470 194 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 118472839 Common ligC ATP-dependent DNA ligase MSMEG_6304 97 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 118472901 Common lipA lipoyl synthase MSMEG_4286 191 COG0320 LipA, Lipoate synthase Coenzyme metabolism 118469809 Common - Mpr protein MSMEG_1236 7 None None None 118469780 Common - monoxygenase MSMEG_2045 75 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118470200 Common tal transaldolase MSMEG_3102 134 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 118470858 Common - hypothetical protein MSMEG_3760 6 None None None 118473101 Pathogen - hypothetical protein MSMEG_2149 2 None None None 118468146 Common - dehydrogenase DhgA MSMEG_5402 232 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118469438 Pathogen - hypothetical protein MSMEG_0958 1 None None None 118472234 Common - putative sugar kinase protein MSMEG_3093 181 COG1069 AraB, Ribulose kinase Energy production and conversion 118468641 Pathogen - hypothetical protein MSMEG_6380 1 None None None 118467625 Common nagB glucosamine-6-phosphate deaminase MSMEG_2118 82 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 118468907 Common - Asp/Glu racemase MSMEG_3993 39 COG3473 COG3473, Maleate cis-trans isomerase Secondary metabolites biosynthesis, transport, and catabolism 118471758 Common - phosphoglycerate mutase MSMEG_6088 74 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 118472393 Common - 2-methylcitrate dehydratase 2 MSMEG_6645 69 COG2079 PrpD, Uncharacterized protein involved in propionate catabolism General function prediction only 118472943 Common - hypothetical protein MSMEG_0023 1 None None None 118470794 Common - methyltransferase, putative, family protein MSMEG_1501 20 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118470329 Common - putative transcriptional regulatory protein MSMEG_1963 51 COG3899 COG3899, Predicted ATPase General function prediction only 118472005 Common - PDZ domain family protein MSMEG_1958 96 COG3480 SdrC, Predicted secreted protein containing a PDZ domain Signal transduction mechanisms 118468827 Common - ABC transporter ATP-binding protein, possibly in EF-3 subfamily protein MSMEG_3140 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 118472789 Common rfbD dTDP-4-dehydrorhamnose reductase MSMEG_1825 181 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 118473414 Common - L-carnitine dehydratase/bile acid-inducible protein F MSMEG_0585 115 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118468167 Common - steroid monooxygenase MSMEG_0195 82 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118470559 Common - AMP-binding protein MSMEG_3131 224 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 118470735 Common - transcriptional regulator, putative MSMEG_3360 90 COG1309 AcrR, Transcriptional regulator Transcription 118472671 Common - propanediol utilization protein PduA MSMEG_0272 46 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 118467591 Common ribF bifunctional riboflavin kinase/FMN adenylyltransferase MSMEG_2653 207 COG0196 RibF, FAD synthase Coenzyme metabolism 118473249 Common - putative acyltransferase MSMEG_0390 31 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 118468420 Common - MmpS5 protein MSMEG_1381 1 None None None 118467725 Common add adenosine deaminase MSMEG_1676 111 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 118469481 Common - acetyl-CoA acetyltransferase MSMEG_4920 176 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118472554 Common - anti-sigm factor, ChrR MSMEG_1755 26 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 118468575 Common - HTH-type transcriptional regulator DegA MSMEG_5143 127 COG1609 PurR, Transcriptional regulators Transcription 118468463 Common - ATP-dependent rna helicase, dead/deah box family protein MSMEG_6160 142 COG1205 COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster General function prediction only 118470870 Pathogen - hypothetical protein MSMEG_3919 1 None None None 118470623 Common - antar domain protein MSMEG_0542 20 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 118468724 Common nrdR hypothetical protein MSMEG_2743 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 118468172 Common - hydrolase MSMEG_0806 62 COG2234 Iap, Predicted aminopeptidases General function prediction only 118471984 Common - conserved hypothetical protein TIGR00026 MSMEG_3004 11 None None None 118473630 Common - alpha/beta hydrolase fold MSMEG_0280 120 COG0657 Aes, Esterase/lipase Lipid metabolism 118470822 Common - ABC transporter, permease protein MSMEG_3268 146 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 118471905 Common - transketolase MSMEG_4436 230 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 118468945 Common - cytochrome b561 family protein MSMEG_3710 87 COG3038 CybB, Cytochrome B561 Energy production and conversion 118473557 Common - amino acid permease-associated region MSMEG_1069 162 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118473261 Common - ABC-type transport system ATP-binding protein I MSMEG_1217 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 118468940 Common - LppR protein MSMEG_4555 1 None None None 118472688 Common - 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_3825 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470469 Common - gp236 protein MSMEG_0533 4 None None None 118471836 Common - FadE12_1 MSMEG_4836 162 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118471495 Pathogen - hypothetical protein MSMEG_0584 1 None None None 118468015 Common pstS phosphate ABC transporter, phosphate-binding protein PstS MSMEG_5782 118 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 118471803 Common - glycosyltransferase, group I MSMEG_1207 25 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 118471863 Common - FAD dependent oxidoreductase, putative MSMEG_0288 73 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 118470131 Common - hypothetical protein MSMEG_5172 39 COG3797 COG3797, Uncharacterized protein conserved in bacteria Function unknown 118471406 Common - hypothetical protein MSMEG_5116 8 COG1547 COG1547, Uncharacterized conserved protein Function unknown 118471363 Pathogen - hypothetical protein MSMEG_4224 1 None None None 118468243 Pathogen - hypothetical protein MSMEG_1042 1 None None None 118470853 Common rluB ribosomal large subunit pseudouridine synthase B MSMEG_3740 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 118471190 Common - acetamidase/Formamidase family protein MSMEG_5358 64 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 118470163 Common - crotonobetaine/carnitine-CoA ligase MSMEG_4036 219 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118473903 Common - nitrite extrusion protein MSMEG_0433 61 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 118473811 Common ftsE cell division ATP-binding protein FtsE MSMEG_2089 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 118473589 Pathogen - hypothetical protein MSMEG_5151 1 None None None 118472297 Pathogen - hypothetical protein MSMEG_5461 1 None None None 118469497 Common - methyltransferase MSMEG_1888 23 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118469833 Pathogen - hypothetical protein MSMEG_0493 1 None None None 118474002 Common - hypothetical protein MSMEG_5797 16 None None None 118473040 Common - ribose transport system permease protein RbsC MSMEG_4171 132 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 118467470 Common - hypothetical protein MSMEG_5791 2 None None None 118468809 Common - dehydrogenase/reductase SDR family protein member 10 MSMEG_4382 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118468965 Common - 4-aminobutyrate aminotransferase MSMEG_2487 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 118471249 Common - phosphotransferase enzyme family protein, putative MSMEG_3876 17 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 118469431 Common - sensor protein KdpD MSMEG_5372 207 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 118470737 Common - AP endonuclease, family protein 2 superfamily protein MSMEG_4653 80 COG3622 Hfi, Hydroxypyruvate isomerase Carbohydrate transport and metabolism 118471294 Common - putative magnesium transport protein MSMEG_0111 129 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 118471255 Common - hypothetical protein MSMEG_0934 10 None None None 118469513 Common - hypothetical protein MSMEG_4821 35 COG5470 COG5470, Uncharacterized conserved protein Function unknown 118467692 Common - acyltransferase MSMEG_0947 30 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 118473950 Common - rhizopine catabolism protein MSMEG_1304 200 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 118471354 Common pcrA ATP-dependent DNA helicase PcrA MSMEG_5534 230 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 118469891 Common atpB F0F1 ATP synthase subunit A MSMEG_4942 202 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 118473454 Common - transcriptional regulator MSMEG_0321 41 COG3899 COG3899, Predicted ATPase General function prediction only 118469841 Common - flavin-type hydroxylase MSMEG_2252 144 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118471503 Common - oxidoreductase MSMEG_3137 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 118470705 Common - hypothetical protein MSMEG_5016 27 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 118471417 Pathogen - hypothetical protein MSMEG_2479 1 None None None 118473964 Common - DNA translocase FtsK MSMEG_2690 199 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 118473031 Common - diguanylate cyclase (ggdef) domain protein MSMEG_2774 14 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 118473242 Common - transcriptional regulator, GntR family protein MSMEG_3980 74 COG1802 GntR, Transcriptional regulators Transcription 118470443 Common - transcriptional regulator, AsnC family protein MSMEG_3988 7 COG1522 Lrp, Transcriptional regulators Transcription 118473580 Pathogen - hypothetical protein MSMEG_4160 1 None None None 118467867 Common recB exodeoxyribonuclease V, beta subunit MSMEG_1327 206 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 118468610 Pathogen - hypothetical protein MSMEG_0477 1 None None None 118468258 Common - LprB protein MSMEG_1396 3 None None None 118470609 Common - gp35 protein MSMEG_5315 26 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 118469237 Common - hypothetical protein MSMEG_4410 4 None None None 118469368 Common - hypothetical protein MSMEG_5752 6 None None None 118473455 Common - hypothetical protein MSMEG_1362 1 None None None 118472254 Pathogen - hypothetical protein MSMEG_6517 1 None None None 118467950 Common - acyl-CoA dehydrogenase family protein MSMEG_2070 158 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472043 Common - two-component regulator MSMEG_5987 172 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118467361 Common argR arginine repressor MSMEG_3771 81 COG1438 ArgR, Arginine repressor Transcription 118469285 Common - alpha-amylase family protein MSMEG_4916 61 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 118467785 Common nuoI NADH dehydrogenase subunit I MSMEG_2055 194 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 118468328 Pathogen - hypothetical protein MSMEG_4679 1 None None None 118470911 Common - transposase MSMEG_4106 48 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 118467520 Common - aryl-alcohol dehydrogenase MSMEG_4039 198 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 118470094 Common - probable membrane protein MSMEG_3523 1 None None None 118470591 Common - hypothetical protein MSMEG_0204 4 None None None 118473735 Pathogen - hypothetical protein MSMEG_4016 1 None None None 118468431 Common - IS1096, tnpR protein MSMEG_4402 44 None None None 118473653 Common hybA hydrogenase-2, small subunit MSMEG_2262 79 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 118470322 Common xseB exodeoxyribonuclease VII, small subunit MSMEG_5227 67 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 118467978 Common - hypothetical protein MSMEG_5002 33 COG4717 COG4717, Uncharacterized conserved protein Function unknown 118469391 Common - putative secreted protein MSMEG_5926 9 COG5337 CotH, Spore coat assembly protein Cell envelope biogenesis, outer membrane 118471193 Common - hypothetical protein MSMEG_0090 19 COG1289 COG1289, Predicted membrane protein Function unknown 118473037 Common argF ornithine carbamoyltransferase MSMEG_3772 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 118468160 Common - hypothetical protein MSMEG_1262 2 None None None 118473687 Common - hypothetical protein MSMEG_6656 10 None None None 118467673 Common - short chain dehydrogenase MSMEG_2899 233 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118471398 Common - secreted protein MSMEG_2353 61 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118469995 Common - bacterial extracellular solute-binding protein, family protein 5 MSMEG_2963 12 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 118470460 Common - transcriptional regulator, TetR family protein MSMEG_6764 59 COG1309 AcrR, Transcriptional regulator Transcription 118468308 Common - ATP-binding protein MSMEG_0178 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 118473057 Common - 50S ribosomal protein L25/general stress protein Ctc MSMEG_5431 173 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 118471002 Common mraY phospho-N-acetylmuramoyl-pentapeptide-transferase MSMEG_4230 208 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 118473087 Common pyc pyruvate carboxylase MSMEG_2412 233 COG1038 PycA, Pyruvate carboxylase Energy production and conversion 118471421 Common - cytochrome P450 MSMEG_4829 77 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118467500 Common - dimethylmenaquinone methyltransferase MSMEG_4435 65 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 118470516 Common - hypothetical protein MSMEG_2698 8 COG4308 LimA, Limonene-1,2-epoxide hydrolase Secondary metabolites biosynthesis, transport, and catabolism 118472695 Common - virulence factor Mce family protein MSMEG_0138 6 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118469370 Common - hypothetical protein MSMEG_2620 5 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 118469612 Common - putative rhamnose catabolism operon transcriptional regulator MSMEG_0592 128 COG1609 PurR, Transcriptional regulators Transcription 118467463 Common - D-ribose-binding periplasmic protein RbsB MSMEG_4172 100 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118469909 Common - hypothetical protein MSMEG_0243 1 None None None 118468153 Common - O-methyltransferase MSMEG_2213 29 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 118470663 Common - oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_2013 237 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118467603 Common - transcriptional regulatory protein MSMEG_6125 192 COG0583 LysR, Transcriptional regulator Transcription 118469188 Common - hypothetical protein MSMEG_4353 1 None None None 118471383 Common - glycosyl transferase, group 2 family protein MSMEG_5084 101 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 118468303 Common - RmlD substrate binding domain superfamily protein MSMEG_5233 52 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118468115 Common - transcriptional regulator, MerR family protein MSMEG_0713 82 COG0789 SoxR, Predicted transcriptional regulators Transcription 118471014 Common - Mmp14a protein MSMEG_0381 54 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118470638 Common - secreted protein MSMEG_6482 12 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 118470474 Common - putative HTH-type transcriptional regulator MSMEG_3527 120 COG2186 FadR, Transcriptional regulators Transcription 118468523 Common - probable exported protein MSMEG_5785 5 None None None 118471859 Pathogen - hypothetical protein MSMEG_2551 1 None None None 118473154 Pathogen - hypothetical protein MSMEG_5232 1 None None None 118473106 Common - cell division protein MSMEG_6105 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 118467516 Common - ISMsm3, transposase MSMEG_6146 10 None None None 118472617 Common - putative sugar isomerase, AgaS family protein MSMEG_0511 25 COG2222 AgaS, Predicted phosphosugar isomerases Cell envelope biogenesis, outer membrane 118473657 Common - oxidoreductase MSMEG_6747 169 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118472871 Common - metallo-beta-lactamase family protein MSMEG_6339 43 COG2015 COG2015, Alkyl sulfatase and related hydrolases Secondary metabolites biosynthesis, transport, and catabolism 118473482 Common - integral membrane protein MSMEG_1571 7 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 118468455 Pathogen - keratin associated protein MSMEG_0979 1 None None None 118467915 Common - carboxylate-amine ligase MSMEG_3326 63 COG2170 COG2170, Uncharacterized conserved protein Function unknown 118470657 Common - probable arabinosyltransferase A MSMEG_6389 5 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 118471794 Common - phosphonate-binding periplasmic protein MSMEG_0649 93 COG3221 PhnD, ABC-type phosphate/phosphonate transport system, periplasmic component Inorganic ion transport and metabolism 118467564 Common - transcriptional regulator MSMEG_5282 17 COG1309 AcrR, Transcriptional regulator Transcription 118472472 Common hutF N-formimino-L-glutamate deiminase MSMEG_1181 99 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 118470070 Common - enoyl-CoA hydratase MSMEG_3390 150 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118467959 Common - GntR-family protein transcriptional regulator MSMEG_2323 201 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 118468352 Pathogen - hypothetical protein MSMEG_0803 1 None None None 118469215 Common - glycosyl transferase, group 2 family protein MSMEG_1097 15 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 118469145 Common - Fic protein family protein MSMEG_2140 91 COG3177 COG3177, Uncharacterized conserved protein Function unknown 118468975 Common - hypothetical protein MSMEG_2645 1 None None None 118469309 Common tyrS tyrosyl-tRNA synthetase MSMEG_3758 216 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 118473400 Common - hypothetical protein MSMEG_1150 1 None None None 118469095 Pathogen - hypothetical protein MSMEG_4759 1 None None None 118472927 Common argD acetylornithine aminotransferase MSMEG_3773 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 118473329 Common - diacylglycerol kinase MSMEG_4335 94 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 118469298 Common - hypothetical protein MSMEG_6760 35 COG3832 COG3832, Uncharacterized conserved protein Function unknown 118467574 Common - hypothetical protein MSMEG_3908 16 None None None 118473137 Common - putative acyl-CoA dehydrogenase MSMEG_5491 153 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118468212 Common - ABC-type molybdenum transport system, ATPase component MSMEG_2326 249 COG1119 ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA Inorganic ion transport and metabolism 118473618 Common - cell surface polysaccharide biosynthesis, putative MSMEG_5954 9 COG3944 COG3944, Capsular polysaccharide biosynthesis protein Cell envelope biogenesis, outer membrane 118471037 Common - D-amino acid deaminase MSMEG_3786 56 COG3616 COG3616, Predicted amino acid aldolase or racemase Amino acid transport and metabolism 118469299 Common - hypothetical protein MSMEG_5969 5 None None None 118472694 Common - integral membrane transport protein MSMEG_0190 74 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 118473566 Common malQ 4-alpha-glucanotransferase MSMEG_3673 116 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 118473460 Pathogen - hypothetical protein MSMEG_6357 1 None None None 118472371 Pathogen - hypothetical protein MSMEG_6559 1 None None None 118469379 Common - probable conserved transmembrane protein MSMEG_1817 12 COG2246 COG2246, Predicted membrane protein Function unknown 118471040 Common - hypothetical protein MSMEG_4347 4 None None None 118469263 Common - stas domain, putative MSMEG_0586 1 None None None 118472546 Common - channel protein, hemolysin III family protein MSMEG_5257 118 COG1272 COG1272, Predicted membrane protein, hemolysin III homolog General function prediction only 118471691 Common proA gamma-glutamyl phosphate reductase MSMEG_4584 187 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 118468512 Common - beta-lactamase MSMEG_3376 71 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 118468865 Common - hydrolase, isochorismatase family protein MSMEG_4126 74 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 118472592 Common - transcriptional regulator, GntR family protein MSMEG_1227 92 COG2188 PhnF, Transcriptional regulators Transcription 118469461 Common - diol dehydrase gamma subunit MSMEG_6320 13 COG4910 PduE, Propanediol dehydratase, small subunit Secondary metabolites biosynthesis, transport, and catabolism 118471985 Common - NAD(P)H-dependent glycerol-3-phosphate dehydrogenase MSMEG_1140 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 118471381 Common phoU phosphate transport system regulatory protein PhoU MSMEG_1605 191 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 118469074 Common - dibenzothiophene desulfurization enzyme A MSMEG_6734 67 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118469735 Pathogen - hypothetical protein MSMEG_1859 1 None None None 118473871 Common - metallopeptidase, M24 family protein MSMEG_3034 245 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 118473774 Common - ATP-dependent DNA ligase MSMEG_5570 114 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 118469393 Common - hypothetical protein MSMEG_2445 110 COG0397 COG0397, Uncharacterized conserved protein Function unknown 118471452 Common - hypothetical protein MSMEG_6549 4 None None None 118468931 Common - acyl-CoA dehydrogenase MSMEG_4832 160 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473582 Common - putative conserved membrane alanine rich protein MSMEG_2696 4 None None None 118467486 Common - hypothetical protein MSMEG_5135 1 None None None 118472851 Pathogen - hypothetical protein MSMEG_5646 1 None None None 118469587 Pathogen - hypothetical protein MSMEG_4747 1 None None None 118473975 Common - regulator of polyketide synthase expression, putative MSMEG_0500 26 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 118469300 Common thiG thiazole synthase MSMEG_0793 166 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 118472029 Common - fur family protein transcriptional regulator MSMEG_6253 168 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 118470127 Common - conserved large membrane protein MSMEG_2677 58 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118471771 Common relA GTP pyrophosphokinase MSMEG_2965 207 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 118467406 Common - transcriptional regulator MdcY family protein MSMEG_1995 129 COG1802 GntR, Transcriptional regulators Transcription 118470719 Common - transporter, small conductance mechanosensitive ion channel (MscS) family protein MSMEG_1315 121 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 118470450 Common ssuD nitrilotriacetate monooxygenase component A MSMEG_4552 62 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118468834 Common - acyl-CoA synthetase MSMEG_0411 202 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118469957 Common - putative glycosyltransferase MSMEG_2342 50 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 118468723 Common - enoyl-CoA hydratase MSMEG_5915 180 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118473303 Common - hypothetical protein MSMEG_6498 1 None None None 118469477 Common dxs 1-deoxy-D-xylulose-5-phosphate synthase MSMEG_2776 207 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 118471811 Common hisD histidinol dehydrogenase MSMEG_3205 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 118467529 Common - 1-aminocyclopropane-1-carboxylate deaminase MSMEG_6740 154 COG2515 Acd, 1-aminocyclopropane-1-carboxylate deaminase Amino acid transport and metabolism 118470059 Common - glycosyl transferase, family protein 2 MSMEG_5963 22 COG5653 COG5653, Protein involved in cellulose biosynthesis (CelD) Cell envelope biogenesis, outer membrane 118473193 Common - RhtB family protein transporter MSMEG_3364 57 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 118472583 Common ctaD cytochrome c oxidase, subunit I MSMEG_4437 166 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 118470743 Common - putative transcriptional regulatory protein MSMEG_6480 5 COG1309 AcrR, Transcriptional regulator Transcription 118472757 Common - hypothetical protein MSMEG_4264 1 None None None 118469384 Common - kinase, pfkB family protein MSMEG_6801 41 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 118471125 Common - molybdopterin oxidoreductase MSMEG_6816 186 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 118473724 Pathogen - hypothetical protein MSMEG_5092 1 None None None 118472240 Common - monoglyceride lipase MSMEG_0220 142 COG2267 PldB, Lysophospholipase Lipid metabolism 118471436 Common - monoxygenase MSMEG_4082 74 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118468113 Common - glyoxalase/bleomycin resistance protein/dioxygenase MSMEG_4776 13 None None None 118468521 Common - ABC transporter ATP-binding protein MSMEG_5661 246 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 118467753 Common mdcC malonate decarboxylase acyl carrier protein MSMEG_6633 20 None None None 118469156 Pathogen - hypothetical protein MSMEG_6930 1 None None None 118472113 Common - HNH nuclease MSMEG_4691 8 None None None 118470678 Common - carboxylesterase MSMEG_1570 15 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118472765 Common - putative ECF sigma factor RpoE1 MSMEG_4405 159 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118469664 Pathogen - hypothetical protein MSMEG_0328 1 None None None 118468779 Common - probable sugar ABC transporter, substrate-binding protein, putative MSMEG_0505 74 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118472415 Pathogen - hypothetical protein MSMEG_5585 1 None None None 118470986 Common - probable conserved transmembrane protein rich in alanine MSMEG_6099 3 COG5373 COG5373, Predicted membrane protein Function unknown 118472247 Common - tetracycline-resistance determinant TetV MSMEG_5187 121 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118468617 Common - TetR-family protein transcriptional regulator MSMEG_6244 62 COG1309 AcrR, Transcriptional regulator Transcription 118471659 Common - ABC transporter, ATP-binding protein GluA MSMEG_6911 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 118469798 Common - Na+/H+ antiporter MSMEG_5825 59 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 118472615 Common - hypothetical protein MSMEG_1955 8 None None None 118473166 Common efp elongation factor P MSMEG_3035 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 118471153 Common - regulatory protein, LacI MSMEG_2636 126 COG1609 PurR, Transcriptional regulators Transcription 118468510 Common - ABC transporter ATP-binding protein MSMEG_4388 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 118470365 Common - hypothetical protein MSMEG_3024 106 COG0432 COG0432, Uncharacterized conserved protein Function unknown 118471979 Common - Siderophore-interacting protein MSMEG_5039 61 COG2375 ViuB, Siderophore-interacting protein Inorganic ion transport and metabolism 118467718 Common - hypothetical protein MSMEG_5290 1 None None None 118471548 Common - amino-acid acetyltransferase MSMEG_5612 98 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 118470148 Common - D-xylose-binding periplasmic protein MSMEG_6020 90 COG4213 XylF, ABC-type xylose transport system, periplasmic component Carbohydrate transport and metabolism 118472224 Common - MmpS3 protein MSMEG_4265 1 COG5373 COG5373, Predicted membrane protein Function unknown 118468893 Common - hypothetical protein MSMEG_2716 7 None None None 118474037 Common - regulatory protein MSMEG_2971 47 COG3835 CdaR, Sugar diacid utilization regulator Transcription / Signal transduction mechanisms 118471747 Common - sulfatase MSMEG_1228 71 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 118468003 Common - binding-protein-dependent transport systems inner membrane component MSMEG_3110 156 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 118469716 Common - amidohydrolase MSMEG_4289 108 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 118471742 Common - steroid delta-isomerase MSMEG_5258 9 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 118471101 Common - glycosyltransferase MSMEG_0311 148 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 118471066 Common - beta-lactamase MSMEG_3040 132 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 118472743 Common - taurine transport system permease protein TauC MSMEG_0113 163 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 118469672 Common coaA pantothenate kinase MSMEG_5252 75 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 118469704 Common - carboxylic ester hydrolase MSMEG_3303 12 COG4188 COG4188, Predicted dienelactone hydrolase General function prediction only 118467571 Common - glutaryl-CoA dehydrogenase MSMEG_2466 161 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472086 Common - coenzyme B12-dependent glycerol dehydrogenase small subunit MSMEG_1546 13 COG4910 PduE, Propanediol dehydratase, small subunit Secondary metabolites biosynthesis, transport, and catabolism 118471107 Common - hypothetical protein MSMEG_6469 51 COG2343 COG2343, Uncharacterized protein conserved in bacteria Function unknown 118468234 Common - YhhW family protein MSMEG_0215 147 COG1741 COG1741, Pirin-related protein General function prediction only 118472989 Common - heme peroxidase superfamily protein MSMEG_3136 3 None None None 118473711 Pathogen - hypothetical protein MSMEG_1962 1 None None None 118472324 Common - transcriptional regulator, GntR family protein MSMEG_2453 131 COG1802 GntR, Transcriptional regulators Transcription 118467690 Common - short chain dehydrogenase MSMEG_5812 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471752 Common hutH histidine ammonia-lyase MSMEG_1183 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 118467763 Pathogen - hypothetical protein MSMEG_4789 1 None None None 118469592 Common proB gamma-glutamyl kinase MSMEG_4621 189 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 118473364 Common - gas vesicle synthesis protein MSMEG_5745 1 None None None 118469818 Common - trap transporter, 4tm/12tm fusion protein MSMEG_0984 80 COG4666 COG4666, TRAP-type uncharacterized transport system, fused permease components General function prediction only 118473517 Common - polysaccharide deacetylase, putative MSMEG_4373 123 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 118467461 Common - regulatory protein MSMEG_6700 2 COG2186 FadR, Transcriptional regulators Transcription 118467671 Common - hypothetical protein MSMEG_0052 1 None None None 118471064 Common - enoyl-(acyl carrier protein) reductase MSMEG_3151 193 COG0623 FabI, Enoyl- acyl-carrier-protein 118469617 Common - putative HTH-type transcriptional regulator MSMEG_0180 3 COG1309 AcrR, Transcriptional regulator Transcription 118471661 Common - hypothetical protein MSMEG_4923 37 COG1637 COG1637, Predicted nuclease of the RecB family DNA replication, recombination, and repair 118470510 Common - putative cytochrome P450 123 MSMEG_5038 70 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118472011 Common - putative aliphatic sulfonates transport ATP-binding protein SsuB MSMEG_4587 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 118471871 Common - hypothetical protein MSMEG_6808 2 None None None 118468550 Pathogen - hypothetical protein MSMEG_5506 1 None None None 118468926 Common - sodium/calcium exchanger protein MSMEG_3719 17 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 118471035 Common - carbon monoxide dehydrogenase subunit G (CoxG) family protein MSMEG_0749 31 COG3427 COG3427, Uncharacterized conserved protein Function unknown 118467857 Common pncB nicotinate phosphoribosyltransferase MSMEG_4911 98 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 118468075 Common - hypothetical protein MSMEG_0262 104 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118469180 Common - acyl-CoA synthetase MSMEG_0257 218 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118468169 Common glyS glycyl-tRNA synthetase MSMEG_4485 86 COG0423 GRS1, Glycyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 118473967 Common - Fatty acid desaturase MSMEG_1886 32 COG3239 DesA, Fatty acid desaturase Lipid metabolism 118472330 Common - fasciclin domain protein MSMEG_5196 44 COG2335 COG2335, Secreted and surface protein containing fasciclin-like repeats Cell envelope biogenesis, outer membrane 118471094 Common - acetyltransferase, GNAT family protein MSMEG_3075 25 COG0456 RimI, Acetyltransferases General function prediction only 118471644 Pathogen - hypothetical protein MSMEG_1277 1 None None None 118472381 Common - transcriptional regulator, TetR family protein MSMEG_2225 30 COG1309 AcrR, Transcriptional regulator Transcription 118472465 Common - formate dehydrogenase, beta subunit MSMEG_0160 165 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 118469599 Common - hypothetical protein MSMEG_5362 1 None None None 118472214 Common - hypothetical protein MSMEG_5581 9 COG5522 COG5522, Predicted integral membrane protein Function unknown 118473312 Common - rubredoxin MSMEG_1841 114 COG1773 COG1773, Rubredoxin Energy production and conversion 118468361 Common cobS cobalamin synthase MSMEG_4277 6 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 118468018 Common - 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_3823 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118467853 Pathogen - hypothetical protein MSMEG_0036 1 None None None 118468517 Common - hypothetical protein MSMEG_3170 47 COG2501 COG2501, Uncharacterized conserved protein Function unknown 118473236 Common hemL glutamate-1-semialdehyde aminotransferase MSMEG_0969 236 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 118470386 Common - bacterial extracellular solute-binding protein, family protein 5 MSMEG_2847 189 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 118472021 Common - ATPase associated with various cellular activities, AAA-5 MSMEG_6241 90 COG0714 COG0714, MoxR-like ATPases General function prediction only 118473621 Common - hypothetical protein MSMEG_5505 15 None None None 118467898 Common - membrane-anchored mycosin mycp1 MSMEG_0083 113 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 118472710 Common - methylesterase MSMEG_2343 23 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 118468843 Common - ABC-type drug export system, ATP-binding protein MSMEG_6509 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 118473700 Common - hypothetical protein MSMEG_2498 5 None None None 118470733 Common - putative acyl-CoA dehydrogenase MSMEG_2080 146 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118468264 Common - D-amino acid deaminase MSMEG_6095 48 COG3616 COG3616, Predicted amino acid aldolase or racemase Amino acid transport and metabolism 118469973 Common - acetyl-CoA acetyltransferase MSMEG_5721 172 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118471568 Common sdhC succinate dehydrogenase, cytochrome b556 subunit MSMEG_1672 24 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 118470221 Common - hypothetical protein MSMEG_4693 1 None None None 118469693 Common - hypothetical protein MSMEG_6488 4 COG2140 COG2140, Thermophilic glucose-6-phosphate isomerase and related metalloenzymes Carbohydrate transport and metabolism / General function prediction only 118470063 Common - deoxyguanosinetriphosphate triphosphohydrolase-like protein MSMEG_4483 159 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 118472072 Common - immunogenic protein MPT63 MSMEG_5412 1 None None None 118472657 Common - transcriptional regulator, LacI family protein MSMEG_2011 125 COG1609 PurR, Transcriptional regulators Transcription 118468551 Common - hypothetical protein MSMEG_6624 12 None None None 118471585 Common - tetratricopeptide repeat family protein MSMEG_4339 110 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118471822 Common - peptide synthetase MSMEG_0400 223 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118472534 Common - hypothetical protein MSMEG_2197 1 COG1635 THI4, Flavoprotein involved in thiazole biosynthesis Coenzyme metabolism 118473385 Common - dimethylaniline monooxygenase [N-oxide-forming] 5 MSMEG_2202 78 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118469661 Common - hypothetical protein MSMEG_1356 13 None None None 118468339 Pathogen - hypothetical protein MSMEG_2266 1 None None None 118471599 Common - transcriptional regulator, GntR family protein MSMEG_6300 125 COG1802 GntR, Transcriptional regulators Transcription 118467783 Common - phenoxybenzoate dioxygenase beta subunit MSMEG_4152 73 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 118470948 Common - hypothetical protein MSMEG_1987 8 COG4766 EutQ, Ethanolamine utilization protein Amino acid transport and metabolism 118469791 Pathogen - hypothetical protein MSMEG_3713 1 None None None 118467640 Common - hypothetical protein MSMEG_0230 94 COG1937 COG1937, Uncharacterized protein conserved in bacteria Function unknown 118470410 Common - hypothetical protein MSMEG_5890 3 None None None 118470395 Common - hypothetical protein MSMEG_2109 3 None None None 118470682 Common - hypothetical protein MSMEG_6029 69 COG2267 PldB, Lysophospholipase Lipid metabolism 118469964 Common - DNA polymerase III subunits gamma and tau MSMEG_6285 247 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 118470371 Common - hypothetical protein MSMEG_0254 4 None None None 118468586 Common - Retinal pigment epithelial membrane protein MSMEG_6224 36 COG3670 COG3670, Lignostilbene-alpha,beta-dioxygenase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 118469486 Common fbiC FO synthase MSMEG_5126 85 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 118469645 Common - Trypsin MSMEG_5070 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 118469195 Common - IS1096, tnpR protein MSMEG_0203 44 None None None 118472584 Common - nitroreductase MSMEG_5155 12 COG0778 NfnB, Nitroreductase Energy production and conversion 118469140 Common - conserved membrane-spanning protein MSMEG_5823 16 COG4425 COG4425, Predicted membrane protein Function unknown 118471392 Common - hydrolase MSMEG_0867 99 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 118470430 Pathogen - hypothetical protein MSMEG_2420 1 COG5028 COG5028, Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 Intracellular trafficking and secretion 118470209 Common - hypothetical protein MSMEG_5502 1 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 118471775 Common - hypothetical protein MSMEG_5111 1 None None None 118471076 Common - transporter, major facilitator family protein MSMEG_6379 150 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118473186 Common - carveol dehydrogenase MSMEG_4801 229 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470956 Common rplX 50S ribosomal protein L24 MSMEG_1466 212 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 118467567 Common - metallophosphoesterase MSMEG_2647 11 COG1409 Icc, Predicted phosphohydrolases General function prediction only 118471274 Common - hypothetical protein MSMEG_5091 1 None None None 118470537 Pathogen - hypothetical protein MSMEG_5484 1 None None None 118469969 Common - oxidoreductase, 2-nitropropane dioxygenase family protein MSMEG_3519 41 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 118472365 Common - dipeptide-binding protein of ABC transport system MSMEG_4354 211 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 118467995 Common - LysR-family protein transcriptional regulator MSMEG_5712 178 COG0583 LysR, Transcriptional regulator Transcription 118470814 Common - hypothetical protein MSMEG_2434 11 None None None 118469926 Common - O-acetylhomoserine aminocarboxypropyltransferase MSMEG_1652 206 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 118467453 Common - adenylate and Guanylate cyclase catalytic domain protein MSMEG_3780 25 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 118468986 Common - putative membrane acyltransferase MSMEG_3490 76 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 118473161 Common - DNA polymerase III subunit epsilon MSMEG_6275 189 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 118468677 Common - hypothetical protein MSMEG_6714 9 None None None 118472631 Pathogen - hypothetical protein MSMEG_5938 1 None None None 118468566 Common - hypothetical protein MSMEG_6786 22 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 118471142 Common - probable conserved transmembrane protein MSMEG_1127 4 None None None 118472623 Common - phosphotransferase enzyme family protein MSMEG_2069 54 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 118473173 Common - amidohydrolase family protein MSMEG_0628 32 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118468811 Common - LprG protein MSMEG_3070 5 None None None 118471242 Common deoC deoxyribose-phosphate aldolase MSMEG_0922 136 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 118473367 Pathogen - hypothetical protein MSMEG_6666 1 None None None 118470390 Pathogen - hypothetical protein MSMEG_4613 1 None None None 118469688 Common - hypothetical protein MSMEG_0040 3 None None None 118471941 Common - hypothetical protein MSMEG_2838 5 None None None 118468283 Common - transcriptional regulator, TetR family protein MSMEG_6441 55 COG1309 AcrR, Transcriptional regulator Transcription 118468496 Pathogen - hypothetical protein MSMEG_6640 1 None None None 118471789 Common - cytochrome C biogenesis protein transmembrane region MSMEG_0972 78 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 118467709 Common - integral membrane protein MSMEG_3616 1 COG2261 COG2261, Predicted membrane protein Function unknown 118472464 Common - ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA MSMEG_3215 249 COG1119 ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA Inorganic ion transport and metabolism 118467797 Common - IS1096, tnpR protein MSMEG_2829 44 None None None 118468286 Common - hypothetical protein MSMEG_4782 1 None None None 118470943 Common speB agmatinase MSMEG_3535 152 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 118469989 Common - universal stress protein family protein MSMEG_4207 17 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 118473559 Common - transporter protein MSMEG_2537 154 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118469685 Common - NAD-glutamate dehydrogenase MSMEG_6272 77 COG2902 COG2902, NAD-specific glutamate dehydrogenase Amino acid transport and metabolism 118469697 Common - propionate--CoA ligase MSMEG_5404 219 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 118468461 Common - hypothetical protein MSMEG_0081 1 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 118472397 Common - diacylglycerol kinase, catalytic region MSMEG_1920 66 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 118471551 Common - hypothetical protein MSMEG_4599 1 None None None 118467394 Common - putative glycosyl transferases group 1 MSMEG_0565 184 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 118468954 Common - regulatory protein MSMEG_2600 123 COG1414 IclR, Transcriptional regulator Transcription 118470610 Common - hypothetical protein MSMEG_3836 10 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 118470880 Common - hypothetical protein MSMEG_6158 4 None None None 118473371 Common - hypothetical protein MSMEG_3181 13 None None None 118471607 Common - TPR domain protein MSMEG_3574 26 None None None 118473957 Common - uricase MSMEG_1296 14 COG3648 COG3648, Uricase (urate oxidase) Secondary metabolites biosynthesis, transport, and catabolism 118469136 Common - integral membrane protein MSMEG_3737 46 COG0730 COG0730, Predicted permeases General function prediction only 118468032 Common - 3-Hydroxyacyl-CoA dehydrogenase MSMEG_5183 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470971 Common - regulatory protein GntR, HTH MSMEG_3822 87 COG2186 FadR, Transcriptional regulators Transcription 118469866 Common - oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_4859 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118468412 Common - ABC transporter, membrane spanning protein MSMEG_6523 44 COG4132 COG4132, ABC-type uncharacterized transport system, permease component General function prediction only 118467748 Common - alanine-rich protein MSMEG_0696 1 None None None 118473868 Common - NADH:flavin oxidoreductase/nadh oxidase MSMEG_1645 179 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 118470117 Common - secreted protein MSMEG_2296 97 COG0431 COG0431, Predicted flavoprotein General function prediction only 118469570 Common - NAD dependent epimerase/dehydratase family protein MSMEG_5956 232 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118471215 Pathogen - hypothetical protein MSMEG_0673 1 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 118469223 Common - hypothetical protein MSMEG_2708 1 None None None 118473441 Common - helix-turn-helix, Fis-type MSMEG_0579 15 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 118468501 Common - TetR-family protein transcriptional regulator MSMEG_3520 57 COG1309 AcrR, Transcriptional regulator Transcription 118473433 Common - hypothetical protein MSMEG_5171 59 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 118472975 Common - lyase MSMEG_0212 29 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 118471962 Common - hypothetical protein MSMEG_5768 9 COG1309 AcrR, Transcriptional regulator Transcription 118473649 Common - LamB/YcsF family protein MSMEG_3401 100 COG1540 COG1540, Uncharacterized proteins, homologs of lactam utilization protein B General function prediction only 118468789 Common - glucitol operon repressor MSMEG_0087 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 118468194 Common - quinone oxidoreductase MSMEG_3106 174 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118470334 Common - FMN-dependent monooxygenase MSMEG_5920 53 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118473985 Common - hypothetical protein MSMEG_2040 2 None None None 118473097 Pathogen - hypothetical protein MSMEG_3291 1 None None None 118472907 Common panE 2-dehydropantoate 2-reductase MSMEG_0153 99 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 118470032 Common - fumarate hydratase class I, anaerobic MSMEG_2985 146 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 118467960 Common - transcriptional regulator, TetR family protein MSMEG_2290 23 COG1309 AcrR, Transcriptional regulator Transcription 118468128 Pathogen - hypothetical protein MSMEG_4751 1 None None None 118473115 Common - oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_5966 220 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118472408 Common - putative oxalyl-CoA decarboxylase MSMEG_0157 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 118472874 Common - peptidase S15 MSMEG_1308 59 COG2936 COG2936, Predicted acyl esterases General function prediction only 118474028 Common - glycosyl transferase MSMEG_4987 82 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 118473267 Common - hypothetical protein MSMEG_2996 27 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118470307 Common aroC chorismate synthase MSMEG_3030 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 118471030 Common - dTDP-RhA:a-D-GlcNAc-diphosphoryl polyprenol, a-3-L-rhamnosyl transferase MSMEG_1826 129 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 118471841 Common - oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_1782 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470642 Common - hypothetical protein MSMEG_0562 60 COG2354 COG2354, Uncharacterized protein conserved in bacteria Function unknown 118473221 Common - flavohemoprotein, putative MSMEG_1336 113 COG1017 Hmp, Hemoglobin-like flavoprotein Energy production and conversion 118467668 Common - succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B MSMEG_1899 100 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 118471111 Common - two-component system response regulator MSMEG_4378 173 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118472162 Common - hypothetical protein MSMEG_3857 5 None None None 118472971 Pathogen - hypothetical protein MSMEG_2302 1 None None None 118467823 Common - RNA polymerase sigma factor, sigma-70 family protein MSMEG_4315 34 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118469320 Common - competence-damaged protein MSMEG_2693 45 COG1546 CinA, Uncharacterized protein (competence- and mitomycin-induced) General function prediction only 118468433 Common - tena/thi-4 family protein MSMEG_1458 23 COG5424 COG5424, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C Coenzyme metabolism 118473682 Common - transporter, LysE family protein MSMEG_3203 112 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 118467545 Common - hypothetical protein MSMEG_2416 20 COG3599 DivIVA, Cell division initiation protein Cell division and chromosome partitioning 118474017 Common - bacterial type II secretion system protein F domain MSMEG_6168 5 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 118468623 Common - phenoxybenzoate dioxygenase beta subunit MSMEG_3676 102 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 118470073 Common - GCN5-related N-acetyltransferase MSMEG_5221 26 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 118467366 Common - restriction endonuclease family protein MSMEG_1765 13 COG1787 COG1787, Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes Defense mechanisms 118469426 Common - hypothetical alanine arginine proline rich protein MSMEG_1880 3 None None None 118471056 Common - hypothetical protein MSMEG_6830 6 None None None 118467834 Common - RDD family protein, putative MSMEG_3254 4 COG1714 COG1714, Predicted membrane protein/domain Function unknown 118469679 Common - AmiB MSMEG_1679 114 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 118472179 Common - serine/threonine-protein kinase PK-1 MSMEG_4243 155 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 118470827 Common - isochorismatase family protein MSMEG_2243 76 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 118473822 Common - hypothetical protein MSMEG_4238 10 COG0456 RimI, Acetyltransferases General function prediction only 118468680 Common - hypothetical protein MSMEG_1981 4 None None None 118468686 Common - hypothetical protein MSMEG_1957 24 COG5282 COG5282, Uncharacterized conserved protein Function unknown 118468767 Common - SAM-dependent methyltransferase MSMEG_2330 19 COG1041 COG1041, Predicted DNA modification methylase DNA replication, recombination, and repair 118473898 Common - ammonium transporter family protein MSMEG_4635 195 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 118473476 Common - putative C4 decarboxylate transport protein MSMEG_6846 31 COG3090 DctM, TRAP-type C4-dicarboxylate transport system, small permease component Carbohydrate transport and metabolism 118470649 Common - phosphoribosylglycinamide formyltransferase MSMEG_2361 7 COG3801 COG3801, Uncharacterized protein conserved in bacteria Function unknown 118472603 Common - IS1549, transposase MSMEG_2824 24 COG5421 COG5421, Transposase DNA replication, recombination, and repair 118467792 Common - transcriptional regulator, GntR family protein MSMEG_0874 123 COG2186 FadR, Transcriptional regulators Transcription 118468782 Common - glycosyl transferase MSMEG_1608 50 COG1554 ATH1, Trehalose and maltose hydrolases (possible phosphorylases) Carbohydrate transport and metabolism 118469763 Common - conserved hypothetical proline and threonine rich protein MSMEG_0638 171 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 118472169 Common ahpD alkylhydroperoxidase, AhpD family protein MSMEG_4890 27 COG2128 COG2128, Uncharacterized conserved protein Function unknown 118471326 Common - glutathione peroxidase family protein MSMEG_5837 114 COG0386 BtuE, Glutathione peroxidase Posttranslational modification, protein turnover, chaperones 118467374 Common - glyoxalase/bleomycin resistance protein/dioxygenase MSMEG_4973 21 COG3565 COG3565, Predicted dioxygenase of extradiol dioxygenase family General function prediction only 118467659 Common - alpha/beta hydrolase MSMEG_2203 41 COG1073 COG1073, Hydrolases of the alpha/beta superfamily General function prediction only 118469650 Common hisD histidinol dehydrogenase MSMEG_5656 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 118473639 Common - haloalkane dehalogenase MSMEG_6314 131 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118473437 Common rpmG 50S ribosomal protein L33 MSMEG_6067 130 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 118473829 Common - ABC transporter MSMEG_1704 98 COG4213 XylF, ABC-type xylose transport system, periplasmic component Carbohydrate transport and metabolism 118471833 Common - short chain dehydrogenase MSMEG_3395 236 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118472421 Common - regulatory protein, AsnC/Lrp MSMEG_4457 84 COG1522 Lrp, Transcriptional regulators Transcription 118471482 Common clpP ATP-dependent Clp protease proteolytic subunit MSMEG_4673 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 118467942 Common - formyl-coenzyme A transferase MSMEG_0168 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118473596 Common - transmembrane efflux protein MSMEG_1427 165 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118468441 Common - polysaccharide deacetylase family protein MSMEG_3412 60 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 118469702 Common - oxidoreductase MSMEG_3663 90 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 118471045 Common - hypothetical protein MSMEG_0682 9 None None None 118467891 Common cysM cysteine synthase B MSMEG_4905 221 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 118473882 Common - sensor kinase MSMEG_2813 29 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 118472945 Common - 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_4163 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118468298 Common - nuclear transport factor 2 (NTF2) domain family protein MSMEG_3684 3 None None None 118468375 Common - adenylate and Guanylate cyclase catalytic domain protein MSMEG_0228 101 COG3899 COG3899, Predicted ATPase General function prediction only 118470459 Common - transcriptional regulator, CarD family protein MSMEG_6077 84 COG1329 COG1329, Transcriptional regulators, similar to M. xanthus CarD Transcription 118471652 Common - putative thiolase MSMEG_2236 115 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118473204 Common - glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein MSMEG_2942 34 COG3565 COG3565, Predicted dioxygenase of extradiol dioxygenase family General function prediction only 118472557 Common - glycerol dehydratase large subunit MSMEG_6321 13 COG4909 PduC, Propanediol dehydratase, large subunit Secondary metabolites biosynthesis, transport, and catabolism 118473704 Common rplU 50S ribosomal protein L21 MSMEG_4625 213 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 118469540 Pathogen - hypothetical protein MSMEG_0804 1 None None None 118468660 Common - stress responsive A/B Barrel Domain family protein MSMEG_2886 6 None None None 118469888 Common - secreted protein MSMEG_4210 68 COG3181 COG3181, Uncharacterized protein conserved in bacteria Function unknown 118469825 Common - putative carboxylesterase/lipase MSMEG_6852 88 COG0657 Aes, Esterase/lipase Lipid metabolism 118469804 Common - probable IclR family protein regulator MSMEG_3423 97 COG1414 IclR, Transcriptional regulator Transcription 118472953 Pathogen - hypothetical protein MSMEG_4413 1 None None None 118471854 Common pcaH protocatechuate 3,4-dioxygenase, beta subunit MSMEG_2601 39 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 118472561 Common - short chain dehydrogenase MSMEG_3994 236 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118468628 Pathogen - hypothetical protein MSMEG_4390 1 None None None 118472447 Common - PIN domain protein MSMEG_1284 17 COG3742 COG3742, Uncharacterized protein conserved in bacteria Function unknown 118473543 Common - hypothetical protein MSMEG_0342 2 None None None 118472280 Common - hypothetical protein MSMEG_5262 7 None None None 118471540 Common - succinate dehydrogenase [ubiquinone] flavoprotein subunit MSMEG_1693 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 118467428 Common - HpcH/HpaI aldolase/citrate lyase family protein, putative MSMEG_2667 109 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 118470759 Common - monooxygenase MSMEG_5732 33 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118470260 Common - putative acyl-CoA dehydrogenase MSMEG_5199 187 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118467535 Common - short chain dehydrogenase MSMEG_6581 227 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118470556 Common - FAD-binding 9, siderophore-interacting MSMEG_0011 56 COG2375 ViuB, Siderophore-interacting protein Inorganic ion transport and metabolism 118470574 Pathogen - hypothetical protein MSMEG_5803 1 None None None 118468408 Common - oxygenase KshA MSMEG_2870 83 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 118469722 Common - MmpL11 protein MSMEG_0241 43 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118469411 Common - AMP-dependent synthetase and ligase MSMEG_0318 214 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118470025 Common - hypothetical protein MSMEG_6609 2 None None None 118473632 Pathogen - hypothetical protein MSMEG_6550 1 None None None 118470505 Common - 6-oxocamphor hydrolase MSMEG_2948 145 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118470939 Common - 6-phosphogluconate dehydrogenase, NAD-binding MSMEG_5463 160 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 118470286 Common - saccharopine dehydrogenase MSMEG_4632 31 COG3268 COG3268, Uncharacterized conserved protein Function unknown 118473751 Common - DNA-binding protein MSMEG_6368 10 None None None 118468703 Common - leupeptin-inactivating enzyme 1 MSMEG_0807 51 COG2234 Iap, Predicted aminopeptidases General function prediction only 118470525 Pathogen - hypothetical protein MSMEG_1781 1 None None None 118468203 Common - hypothetical protein MSMEG_6188 1 None None None 118472833 Common speB agmatinase MSMEG_4459 156 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 118468687 Common - Carboxyl transferase domain protein MSMEG_0333 144 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 118472306 Common - ABC transporter, periplasmic substrate-binding protein, putative MSMEG_6668 68 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 118467386 Common - putative ABC transporter, periplasmic protein MSMEG_0486 55 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 118473073 Common ptsI phosphoenolpyruvate-protein phosphotransferase MSMEG_0088 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 118473126 Common - virulence factor mce family protein MSMEG_0351 15 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118473130 Common - ribose transport system permease protein RbsC MSMEG_6803 111 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 118470517 Common - 2-deoxy-scyllo-inosamine dehydrogenase MSMEG_1795 208 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 118473594 Common - orotate phosphoribosyltransferase MSMEG_6520 181 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 118470347 Common - possible drug efflux membrane protein MSMEG_3815 104 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118473853 Common - [NiFe] hydrogenase, alpha subunit, putative MSMEG_3928 91 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 118473046 Pathogen - hypothetical protein MSMEG_4015 1 None None None 118471998 Common - hypothetical protein MSMEG_3032 3 None None None 118471615 Common - virulence factor mce family protein MSMEG_0137 6 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118470888 Common - integral membrane protein MSMEG_3045 9 None None None 118470177 Common - ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components MSMEG_3601 157 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 118471796 Common - hypothetical protein MSMEG_6081 10 None None None 118473003 Common - putative oxalyl-CoA decarboxylase MSMEG_5297 218 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 118473784 Common - metallo-beta-lactamase family protein MSMEG_6190 170 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 118472917 Common - integral membrane protein MSMEG_5178 36 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118469533 Common - probable conserved integral membrane protein MSMEG_4246 6 None None None 118471167 Common - condensation domain protein MSMEG_4728 11 None None None 118468120 Common - transcriptional regulator, TetR family protein MSMEG_1565 117 COG1309 AcrR, Transcriptional regulator Transcription 118467582 Common - phosphocarrier protein hpr MSMEG_0084 30 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 118469746 Common glpK glycerol kinase MSMEG_6756 179 COG0554 GlpK, Glycerol kinase Energy production and conversion 118472822 Common - short-chain dehydrogenase/reductase SDR MSMEG_1760 213 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118469756 Common - hypothetical protein MSMEG_2037 33 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118472136 Common dapB dihydrodipicolinate reductase, N-terminus domain protein MSMEG_3317 21 COG3804 COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase Function unknown 118469847 Common - putative monovalent cation/H+ antiporter subunit D MSMEG_0846 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 118473919 Common - nicotinamidase/pyrazinamidase MSMEG_6506 103 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 118470048 Common mqo malate:quinone oxidoreductase MSMEG_2613 55 COG0579 COG0579, Predicted dehydrogenase General function prediction only 118471375 Common - hypothetical protein MSMEG_1252 99 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 118472050 Common - hypothetical protein MSMEG_5501 1 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 118471464 Common - urease accessory protein UreD, putative MSMEG_1096 8 COG0829 UreH, Urease accessory protein UreH Posttranslational modification, protein turnover, chaperones 118473150 Common - conserved 13e12 repeat family protein MSMEG_3957 5 None None None 118469244 Common - hypothetical protein MSMEG_5677 4 None None None 118469875 Common - dipeptide transport system permease protein DppB MSMEG_6866 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118472034 Common - hypothetical protein MSMEG_0345 150 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 118470068 Common - sugar transporter family protein MSMEG_0985 133 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118472269 Common - hydrolase, carbon-nitrogen family protein MSMEG_0924 197 COG0388 COG0388, Predicted amidohydrolase General function prediction only 118472507 Pathogen - hypothetical protein MSMEG_5875 1 None None None 118468020 Common - glutamate-1-semialdehyde 2,1-aminomutase MSMEG_0661 236 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 118471770 Common - LppW protein MSMEG_2439 9 None None None 118469202 Common - hypothetical protein MSMEG_0027 25 COG3879 COG3879, Uncharacterized protein conserved in bacteria Function unknown 118470097 Common - transcriptional regulator, LytR family protein MSMEG_1824 64 COG1316 LytR, Transcriptional regulator Transcription 118471575 Common - transcriptional regulator, TetR family protein MSMEG_0465 30 COG1309 AcrR, Transcriptional regulator Transcription 118467632 Common - secreted protein MSMEG_1016 97 COG0431 COG0431, Predicted flavoprotein General function prediction only 118469419 Common - hypothetical protein MSMEG_3952 21 None None None 118469657 Common - GAF family protein MSMEG_4614 81 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 118473018 Common - integral membrane protein MSMEG_3234 16 COG3247 HdeD, Uncharacterized conserved protein Function unknown 118472992 Common - putative aldehyde or xanthine dehydrogenase, molybdopterin binding subunit protein MSMEG_0871 87 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 118468797 Pathogen - hypothetical protein MSMEG_3244 1 COG5373 COG5373, Predicted membrane protein Function unknown 118469033 Common - transcriptional regulator, AraC family protein MSMEG_5193 140 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 118472158 Pathogen - hypothetical protein MSMEG_5289 1 None None None 118472097 Common - hypothetical protein MSMEG_3377 1 COG4982 COG4982, 3-oxoacyl- acyl-carrier protein 118471359 Common - mce-family protein mce1f MSMEG_4785 10 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118468394 Common - hypothetical protein MSMEG_6606 3 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 118471809 Common - hypothetical protein MSMEG_0707 39 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 118467436 Common - tetratricopeptide repeat domain protein MSMEG_4917 157 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 118468086 Pathogen - hypothetical protein MSMEG_3202 1 None None None 118469753 Common - membrane protein implicated in regulation of membrane protease activity MSMEG_3154 15 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 118473378 Common - ABC polar amino acid family protein transporter, inner membrane subunit MSMEG_0177 179 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 118468182 Common - bacterial extracellular solute-binding protein, family protein 5 MSMEG_4545 185 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 118467711 Common - hypothetical protein MSMEG_3699 4 None None None 118471361 Common - hypothetical protein MSMEG_5127 1 None None None 118471118 Common - hypothetical protein MSMEG_0223 2 None None None 118471720 Common - hypothetical protein MSMEG_0728 1 None None None 118468324 Common - carveol dehydrogenase MSMEG_5813 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471620 Common - 3-ketoacyl-ACP/CoA redutase MSMEG_2029 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118472510 Common - hypothetical protein MSMEG_1929 5 None None None 118469059 Common - Periplasmic binding protein MSMEG_0020 68 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 118470437 Common - hypothetical protein MSMEG_1288 22 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 118469947 Common - FMN-dependent monooxygenase MSMEG_0339 48 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118472519 Common - 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_4835 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471592 Common - puromycin N-acetyltransferase MSMEG_4563 16 COG3153 COG3153, Predicted acetyltransferase General function prediction only 118468471 Common - amidate substrates transporter protein MSMEG_5336 17 None None None 118472288 Common - AMP-dependent synthetase and ligase MSMEG_2217 214 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118471334 Common - Mov34/MPN/PAD-1 family protein MSMEG_4907 31 COG1310 COG1310, Predicted metal-dependent protease of the PAD1/JAB1 superfamily General function prediction only 118472201 Common - hypothetical protein MSMEG_3503 2 None None None 118472435 Common - putative transcriptional regulatory protein MSMEG_6913 16 COG1846 MarR, Transcriptional regulators Transcription 118467741 Common - transcriptional regulator MSMEG_2182 75 COG1309 AcrR, Transcriptional regulator Transcription 118469210 Common - fumarate reductase iron-sulfur subunit MSMEG_0417 206 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 118468355 Common - hydroxylaminobenzene mutase MSMEG_3456 2 None None None 118473533 Common - integral membrane protein MSMEG_0999 6 COG5305 COG5305, Predicted membrane protein Function unknown 118473298 Common - succinic semialdehyde dehydrogenase MSMEG_0889 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118468745 Common - hypothetical protein MSMEG_0798 1 None None None 118471670 Common - putative transcriptional regulator MSMEG_6479 43 COG1309 AcrR, Transcriptional regulator Transcription 118469494 Common - IS1096, tnpA protein MSMEG_2003 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118471698 Common - short chain dehydrogenase MSMEG_0876 213 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471637 Common - cytochrome P450 FAS1 MSMEG_0762 80 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118469297 Common - ABC transporter, ATP-binding protein MSMEG_6309 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 118468601 Common - DoxX subfamily protein, putative MSMEG_5179 2 COG2259 COG2259, Predicted membrane protein Function unknown 118468867 Pathogen - hypothetical protein MSMEG_4364 1 None None None 118473879 Common - vanillate O-demethylase oxidoreductase MSMEG_4009 46 None None None 118467378 Pathogen - hypothetical protein MSMEG_4503 1 None None None 118471915 Common - putative transporter MSMEG_3990 157 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118469603 Common - hypothetical protein MSMEG_3709 7 None None None 118472620 Common - alpha-mannosidase MSMEG_1361 46 COG0383 AMS1, Alpha-mannosidase Carbohydrate transport and metabolism 118470112 Common - ErfK/YbiS/YcfS/YnhG family protein MSMEG_4745 21 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 118467515 Common - acetyl-CoA acetyltransferase MSMEG_5273 185 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118473085 Common - nudix hydrolase MSMEG_5118 112 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 118472044 Common - hypothetical protein MSMEG_0292 4 None None None 118473288 Common eda 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase MSMEG_0312 125 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 118472453 Pathogen - hypothetical protein MSMEG_0094 1 None None None 118473689 Common - polysaccharide deacetylase family protein MSMEG_4130 59 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 118472108 Common asnB asparagine synthase (glutamine-hydrolyzing) MSMEG_2594 167 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 118468847 Common - IS1096, tnpR protein MSMEG_5093 44 None None None 118469743 Common - hypothetical protein MSMEG_3845 19 COG1872 COG1872, Uncharacterized conserved protein Function unknown 118471738 Common - amidohydrolase 2 MSMEG_5364 44 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118471303 Common - hypothetical protein MSMEG_6145 1 None None None 118472401 Common - hypothetical protein MSMEG_3530 1 None None None 118468173 Common - beta-lactamase MSMEG_6805 155 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 118471573 Common - MmpL4 protein MSMEG_0576 70 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118471199 Common - tetratricopeptide repeat protein, putative MSMEG_1855 4 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 118469227 Common - UsfY protein MSMEG_1791 2 None None None 118467353 Common - ABC-type cobalt transport system MSMEG_6724 33 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 118469514 Common glmS D-fructose-6-phosphate amidotransferase MSMEG_1568 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 118467712 Common - amino acid permease-associated region MSMEG_1137 143 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118469717 Common upp uracil phosphoribosyltransferase MSMEG_3473 166 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 118471616 Common - conserved hypothetical alanine and leucine rich protein MSMEG_2746 20 COG2047 COG2047, Uncharacterized protein (ATP-grasp superfamily) General function prediction only 118472728 Common - hypothetical protein MSMEG_0407 24 COG3804 COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase Function unknown 118468302 Common - aliphatic amidase MSMEG_0566 178 COG0388 COG0388, Predicted amidohydrolase General function prediction only 118470018 Common - peptide synthetase ScpsB, putative MSMEG_3924 6 None None None 118473622 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin MSMEG_4203 73 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 118472147 Pathogen - hypothetical protein MSMEG_1723 1 None None None 118473211 Common - hypothetical protein MSMEG_6352 11 None None None 118470707 Common - hypothetical protein MSMEG_3374 4 COG3662 COG3662, Uncharacterized protein conserved in bacteria Function unknown 118469626 Common - choline dehydrogenase MSMEG_3444 94 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 118467493 Common - MmpL4 protein MSMEG_0225 95 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118473252 Common - starvation-induced DNA protecting protein MSMEG_6467 113 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 118468482 Common - transcriptional regulator, LysR family protein MSMEG_5654 188 COG0583 LysR, Transcriptional regulator Transcription 118470922 Common - hypothetical protein MSMEG_0222 6 None None None 118467465 Common - putative transcriptional regulatory protein MSMEG_0676 3 COG1309 AcrR, Transcriptional regulator Transcription 118468875 Common - hypothetical protein MSMEG_3213 24 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 118469484 Common - monoxygenase MSMEG_4551 73 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118468755 Common - hypothetical protein MSMEG_6280 113 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 118469169 Common - translation initiation inhibitor MSMEG_6191 89 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 118469134 Common - type I topoisomerase MSMEG_1784 44 COG3569 COG3569, Topoisomerase IB DNA replication, recombination, and repair 118468879 Common - methylmalonyl-CoA mutase C-terminal domain protein MSMEG_4880 108 COG2185 Sbm, Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) Lipid metabolism 118469902 Common - TetR-family protein transcriptional regulator MSMEG_3425 80 COG1309 AcrR, Transcriptional regulator Transcription 118467957 Common - ABC transporter substrate-binding protein MSMEG_1232 77 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 118467661 Common - hypothetical protein MSMEG_1870 12 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 118467427 Common rpsK 30S ribosomal protein S11 MSMEG_1522 248 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 118468812 Common ald alanine dehydrogenase MSMEG_2659 168 COG0686 Ald, Alanine dehydrogenase Amino acid transport and metabolism 118468287 Common - hypothetical protein MSMEG_1237 1 None None None 118469355 Common dhaK dihydroxyacetone kinase, DhaK subunit MSMEG_2123 77 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 118473713 Common - transcriptional regulator, GntR family protein MSMEG_2605 138 COG2186 FadR, Transcriptional regulators Transcription 118472002 Common - sec-independent translocase MSMEG_5069 8 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 118469086 Common - riboflavin synthase subunit beta MSMEG_6598 176 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 118471095 Common - universal stress protein family protein MSMEG_3936 61 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 118470139 Common - 3-hydroxyisobutyrate dehydrogenase MSMEG_4123 161 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 118473139 Common - hypothetical protein MSMEG_4443 2 None None None 118470692 Common - IS1096, tnpR protein MSMEG_0398 44 None None None 118471872 Common - LppP protein MSMEG_4475 2 None None None 118468155 Common - RNA polymerase ECF-subfamily protein sigma factor MSMEG_1348 48 COG4941 COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain Transcription 118467917 Common recF recombination protein F MSMEG_0003 162 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 118468397 Common - hypothetical protein MSMEG_1176 1 None None None 118468802 Common - pyruvate dehydrogenase MSMEG_2280 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 118471748 Common - hypothetical protein MSMEG_2084 2 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 118469861 Common fbaA fructose-bisphosphate aldolase MSMEG_0752 139 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 118470907 Common - hypothetical protein MSMEG_0423 1 None None None 118471419 Common - phosphoenolpyruvate synthase MSMEG_3934 235 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 118471273 Common - amine oxidase [flavin-containing] B MSMEG_2035 44 COG1231 COG1231, Monoamine oxidase Amino acid transport and metabolism 118469993 Common - ATP-dependent RNA helicase MSMEG_1540 234 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 118471089 Common ssuD nitrilotriacetate monooxygenase component A MSMEG_4091 70 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118468231 Common - LysR-family protein transcriptional regulator MSMEG_0817 187 COG0583 LysR, Transcriptional regulator Transcription 118468859 Common - hypothetical protein MSMEG_0251 6 COG2054 COG2054, Uncharacterized archaeal kinase related to aspartokinases, uridylate kinases General function prediction only 118469230 Common - sugar transporter family protein MSMEG_0232 106 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118467576 Common - para-aminobenzoate synthase component II MSMEG_0029 236 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 118473452 Common - stas domain protein MSMEG_5551 6 None None None 118473800 Common - GTP-binding protein MSMEG_2736 228 COG2262 HflX, GTPases General function prediction only 118468133 Common - amidohydrolase 2 MSMEG_6547 20 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118471501 Common - LacI-family protein transcriptional regulator MSMEG_2954 126 COG1609 PurR, Transcriptional regulators Transcription 118470261 Pathogen - hypothetical protein MSMEG_2783 1 None None None 118473718 Common - hypothetical protein MSMEG_4697 7 None None None 118467846 Common - glutamyl-tRNA(Gln) amidotransferase subunit A MSMEG_3400 228 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 118474005 Common - magnesium or manganese-dependent protein phosphatase MSMEG_6131 205 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 118469610 Pathogen - hypothetical protein MSMEG_4892 1 None None None 118468978 Common - ribose-5-phosphate isomerase B MSMEG_4684 127 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 118471705 Common - putrescine transport ATP-binding protein PotG MSMEG_0662 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 118467512 Common - histidinol-phosphate aminotransferase 2 MSMEG_1491 231 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 118471000 Common - hypothetical protein MSMEG_3509 16 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 118468322 Pathogen - hypothetical protein MSMEG_1314 1 None None None 118473289 Common - nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase MSMEG_3880 9 None None None 118469372 Common - 3-hydroxybutyryl-CoA dehydrogenase MSMEG_4116 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 118468456 Common - penicillin-binding protein 1 MSMEG_6900 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 118473831 Common rhaI L-rhamnose isomerase MSMEG_0589 33 COG4952 COG4952, Predicted sugar isomerase Cell envelope biogenesis, outer membrane 118468338 Common - hypothetical protein MSMEG_4604 1 None None None 118471753 Common - putative transcriptional regulator family protein MSMEG_5610 102 COG1733 COG1733, Predicted transcriptional regulators Transcription 118470913 Common - glycosyl transferase, group 2 family protein, putative MSMEG_5961 109 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 118473402 Common - sensor protein KdpD MSMEG_5395 218 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 118472498 Common - hypothetical protein MSMEG_3795 9 None None None 118470659 Common cobL precorrin-6Y C5,15-methyltransferase (decarboxylating) MSMEG_3878 99 COG2242 CobL, Precorrin-6B methylase 2 Coenzyme metabolism 118469270 Common - dehydrogenase MSMEG_5287 207 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 118469564 Common - ZbpA protein MSMEG_2201 67 COG2030 MaoC, Acyl dehydratase Lipid metabolism 118473920 Common - membrane protein, TerC family protein MSMEG_6136 100 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 118470491 Common gltA type II citrate synthase MSMEG_5672 194 COG0372 GltA, Citrate synthase Energy production and conversion 118473152 Common - hypothetical protein MSMEG_3156 1 None None None 118468445 Common - integral membrane protein MSMEG_4209 15 None None None 118473072 Common tpiA triosephosphate isomerase MSMEG_6785 215 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 118469126 Common - hypothetical protein MSMEG_4219 46 COG1799 COG1799, Uncharacterized protein conserved in bacteria Function unknown 118470553 Common - cytochrome p450 MSMEG_4780 87 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118470606 Common ilvH acetolactate synthase 3 regulatory subunit MSMEG_2373 193 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 118472116 Common - antioxidant, AhpC/TSA family protein MSMEG_4753 218 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 118468148 Common - carbonic anhydrase MSMEG_6082 151 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 118470966 Common - alcohol dehydrogenase, class IV MSMEG_1392 184 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 118472250 Common - bile-acid 7-alpha dehydratase MSMEG_2245 8 None None None 118473105 Common - acyltransferase MSMEG_0319 12 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 118469788 Common - P49 protein MSMEG_2377 47 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118472245 Common - UsfY protein MSMEG_1777 1 None None None 118469196 Common - acyl-CoA dehydrogenase fadE12 MSMEG_0338 157 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118469821 Common sdhB succinate dehydrogenase iron-sulfur subunit MSMEG_1669 207 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 118467784 Common - hypothetical protein MSMEG_3923 13 None None None 118471848 Common - hypothetical protein MSMEG_5558 1 None None None 118469848 Common - 5'-3' exonuclease MSMEG_3883 216 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 118473546 Common - hypothetical protein MSMEG_3542 2 COG3874 COG3874, Uncharacterized conserved protein Function unknown 118473466 Common - major facilitator superfamily protein MSMEG_1798 126 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118473122 Common - short chain dehydrogenase MSMEG_6662 170 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118467656 Common - ethanolamine utilization protein EutN MSMEG_0273 16 COG4576 CcmL, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 118470463 Common gyrB DNA gyrase subunit B MSMEG_1229 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 118472376 Common - hypothetical protein MSMEG_5449 5 None None None 118472318 Common - diaminopimelate decarboxylase MSMEG_6197 216 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 118467997 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase MSMEG_5903 232 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118473861 Common - putative transcriptional regulator, TetR family protein MSMEG_3406 26 COG1309 AcrR, Transcriptional regulator Transcription 118472523 Common - glycolate oxidase subunit MSMEG_0374 202 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 118471340 Common - NADH:flavin oxidoreductase/nadh oxidase MSMEG_2969 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 118473787 Common - transporter, LysE family protein MSMEG_1478 96 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 118472668 Common - hydrolase MSMEG_3891 130 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118473347 Common - transposase MSMEG_1862 108 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 118467689 Pathogen - hypothetical protein MSMEG_5115 1 None None None 118468946 Common - transthyretin MSMEG_1295 63 COG2351 COG2351, Transthyretin-like protein General function prediction only 118467539 Common - aminoglycoside phosphotransferase MSMEG_0270 29 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 118467382 Common - enoyl-CoA hydratase MSMEG_3139 173 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118470873 Common - shikimate transporter MSMEG_6295 141 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118472314 Common - short-chain dehydrogenase/reductase SDR MSMEG_2885 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118467771 Common - hypothetical protein MSMEG_1789 1 None None None 118473216 Common - glutamine synthetase III MSMEG_6693 220 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 118467808 Common - hypothetical protein MSMEG_2863 1 None None None 118472935 Common - hydroxyquinol 1,2-dioxygenase MSMEG_6713 46 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 118471017 Common - hypothetical protein MSMEG_5565 11 COG5514 COG5514, Uncharacterized conserved protein Function unknown 118473361 Common - hypothetical protein MSMEG_6415 50 COG3824 COG3824, Uncharacterized protein conserved in bacteria Function unknown 118470631 Common - peptide ABC transporter, permease protein MSMEG_4355 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118473034 Common - acyltransferase, ws/dgat/mgat subfamily protein MSMEG_4705 26 None None None 118467732 Common - streptomycin 6-kinase (Streptidine kinase) (Streptomycin6-phosphotransferase) (APH(6)) MSMEG_3480 20 COG3570 StrB, Streptomycin 6-kinase Defense mechanisms 118467561 Common - antigen 85-C MSMEG_6399 9 COG0627 COG0627, Predicted esterase General function prediction only 118471904 Pathogen - hypothetical protein MSMEG_1032 1 None None None 118469781 Common - hypothetical protein MSMEG_1560 1 None None None 118470878 Common - hydrolase of the alpha/beta superfamily protein MSMEG_6597 37 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 118470892 Common - hypothetical protein MSMEG_4216 1 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 118470314 Common ligA NAD-dependent DNA ligase LigA MSMEG_2362 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 118468917 Common - HIT family protein MSMEG_5871 211 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 118472966 Common - transcriptional regulator, LysR family protein MSMEG_1985 164 COG0583 LysR, Transcriptional regulator Transcription 118469406 Common - transcriptional regulator, TetR family protein MSMEG_1397 34 COG1309 AcrR, Transcriptional regulator Transcription 118470159 Common - transcriptional regulator, LuxR family protein MSMEG_0473 163 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118469839 Common dnaE DNA polymerase III subunit alpha MSMEG_3178 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 118473394 Pathogen - hypothetical protein MSMEG_4341 1 None None None 118468140 Common - cinnamoyl ester hydrolase MSMEG_5162 139 COG1733 COG1733, Predicted transcriptional regulators Transcription 118471674 Common iscS cysteine desulfurase IscS MSMEG_1242 229 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 118469893 Common - hypothetical protein MSMEG_0099 5 COG2839 COG2839, Uncharacterized protein conserved in bacteria Function unknown 118471708 Common - acyl-CoA dehydrogenase, C- domain protein MSMEG_2233 80 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473205 Common - L-sorbosone dehydrogenase MSMEG_0214 63 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 118470598 Common - acyl-CoA synthetase MSMEG_5291 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118468076 Common - cupin domain protein MSMEG_1688 3 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 118473737 Common - glutamate decarboxylase MSMEG_1574 71 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 118468331 Common - fmnh2-utilizing oxygenase MSMEG_2177 54 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118470061 Common - D-isomer specific 2-hydroxyacid dehydrogenase MSMEG_6126 230 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 118471369 Common - hypothetical protein MSMEG_3135 1 None None None 118469734 Common - putative colanic acid biosynthesis acetyltransferase WcaF MSMEG_5950 122 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 118473872 Common ksgA dimethyladenosine transferase MSMEG_5438 247 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 118472299 Common - PTS system, glucose-specific IIBC component MSMEG_2116 50 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 118472556 Common - 2-Keto-3-deoxy-gluconate kinase MSMEG_2908 34 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 118471137 Common - citrate synthase MSMEG_4035 28 COG0372 GltA, Citrate synthase Energy production and conversion 118471921 Common - hypothetical protein MSMEG_4322 3 None None None 118471767 Common - ABC-type metal ion transport system, permease component MSMEG_3057 104 COG2011 AbcD, ABC-type metal ion transport system, permease component Inorganic ion transport and metabolism 118470133 Common deoA thymidine phosphorylase MSMEG_1675 119 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 118473810 Common dehII haloacid dehalogenase, type II MSMEG_3450 41 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 118472616 Pathogen - glycosyl transferase, group 2 family protein, putative MSMEG_4732 1 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 118473409 Common - NAD(P)H dehydrogenase, quinone family protein MSMEG_5564 93 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 118473440 Common - putative HTH-type transcriptional regulator MSMEG_3129 2 None None None 118472656 Common - major facilitator superfamily protein MSMEG_0716 124 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118469435 Common - single-strand DNA-binding protein MSMEG_6896 200 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 118473197 Common - probable conserved transmembrane protein MSMEG_0315 7 None None None 118468489 Common - glucosamine-6-phosphate deaminase 1 MSMEG_0501 82 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 118469920 Common - putative transcriptional regulator MSMEG_0778 127 COG2188 PhnF, Transcriptional regulators Transcription 118471886 Common - putative conserved transmembrane protein MSMEG_4484 15 COG1512 COG1512, Beta-propeller domains of methanol dehydrogenase type General function prediction only 118470181 Common - putative thiolase MSMEG_4778 92 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118473974 Common - IS1096, tnpA protein MSMEG_6148 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118473817 Pathogen - hypothetical protein MSMEG_6782 1 None None None 118467975 Common - formyl-coenzyme A transferase MSMEG_1154 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118470161 Common - putative transcriptional regulator MSMEG_2583 20 None None None 118471954 Common - 6-phosphogluconate dehydrogenase-like protein MSMEG_0002 182 COG1023 Gnd, Predicted 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 118468059 Pathogen - hypothetical protein MSMEG_1792 1 None None None 118472739 Common - acyl-CoA synthetase MSMEG_2883 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118469011 Common - ISMsm4, transposase MSMEG_2830 43 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118467365 Common - endonuclease/exonuclease/phosphatase MSMEG_1360 30 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 118471355 Common - endoribonuclease L-psp family protein MSMEG_5723 37 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 118473940 Common - MarR-family protein transcriptional regulator MSMEG_5595 50 COG1846 MarR, Transcriptional regulators Transcription 118473840 Common - tRNA (adenine-N(1)-)-methyltransferase MSMEG_3906 58 COG2519 GCD14, tRNA(1-methyladenosine) methyltransferase and related methyltransferases Translation, ribosomal structure and biogenesis 118473586 Common - transcriptional regulator, GntR family protein MSMEG_0179 108 COG1802 GntR, Transcriptional regulators Transcription 118471986 Common hmgA homogentisate 1,2-dioxygenase MSMEG_2075 36 COG3508 HmgA, Homogentisate 1,2-dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 118471295 Common - putative acyltransferase domain protein MSMEG_3187 70 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 118470546 Pathogen - hypothetical protein MSMEG_0366 1 None None None 118467626 Common - proline imino-peptidase MSMEG_2681 124 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118473192 Common - 3-hydroxyacyl-CoA dehydrogenase MSMEG_0216 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118473565 Common - hypothetical protein MSMEG_2854 149 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 118471882 Common - hypothetical protein MSMEG_6417 2 None None None 118469168 Common - sodium:solute symporter MSMEG_4462 108 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 118468313 Common - chloride channel MSMEG_6465 88 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 118472256 Common - hypothetical protein MSMEG_6928 9 None None None 118469583 Common - IS1549, transposase MSMEG_3433 24 COG5421 COG5421, Transposase DNA replication, recombination, and repair 118472811 Common - dtdp-glucose-46-dehydratase MSMEG_4184 7 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118473334 Common - hypothetical protein MSMEG_5840 8 COG4270 COG4270, Predicted membrane protein Function unknown 118472804 Common - virulence factor MSMEG_4794 8 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118470419 Common - transcriptional regulator, TetR family protein MSMEG_4622 10 COG1309 AcrR, Transcriptional regulator Transcription 118467566 Common - NAD-dependent malic enzyme MSMEG_5055 195 COG0281 SfcA, Malic enzyme Energy production and conversion 118470092 Pathogen - hypothetical protein MSMEG_0394 1 None None None 118469529 Common clpX ATP-dependent protease ATP-binding subunit MSMEG_4671 223 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 118469203 Common - hypothetical protein MSMEG_5842 5 None None None 118472123 Common - methyltransferase MSMEG_0098 175 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118474034 Pathogen - hypothetical protein MSMEG_3038 1 None None None 118472140 Common - hypothetical protein MSMEG_5634 5 COG3427 COG3427, Uncharacterized conserved protein Function unknown 118472432 Pathogen - hypothetical protein MSMEG_6841 1 None None None 118472337 Common galK galactokinase MSMEG_3692 88 COG0153 GalK, Galactokinase Carbohydrate transport and metabolism 118472439 Common - putative transcription regulator MSMEG_6857 105 COG1414 IclR, Transcriptional regulator Transcription 118471222 Common - putative oxidoreductase YdbC MSMEG_6730 199 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 118469239 Common - rrf2 family protein (putative transcriptional regulator) MSMEG_4974 176 COG1959 COG1959, Predicted transcriptional regulator Transcription 118473530 Common - probable cutinase MSMEG_1526 3 None None None 118470003 Common dapA dihydrodipicolinate synthase MSMEG_2684 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 118471044 Common ispF 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase MSMEG_6075 148 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 118470761 Common cysW sulfate ABC transporter, permease protein CysW MSMEG_4531 229 COG4208 CysW, ABC-type sulfate transport system, permease component Inorganic ion transport and metabolism 118472180 Common - porin MSMEG_0965 2 None None None 118470729 Common - regulatory protein, LuxR, putative MSMEG_6568 41 COG4566 TtrR, Response regulator Signal transduction mechanisms 118471728 Common - transcriptional regulatory protein MSMEG_1691 38 COG3899 COG3899, Predicted ATPase General function prediction only 118473613 Common modB molybdate ABC transporter, permease protein MSMEG_2015 177 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 118468348 Common pcaC 4-carboxymuconolactone decarboxylase domain protein MSMEG_5856 23 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 118469279 Common - ABC heavy metal transporter, inner membrane subunit MSMEG_6045 189 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 118473537 Common - integral membrane protein DUF6 MSMEG_2542 25 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 118468608 Common - amidohydrolase MSMEG_1703 167 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 118470084 Common - hypothetical protein MSMEG_2258 7 COG2879 COG2879, Uncharacterized small protein Function unknown 118467595 Common - cysteine desulfurase family protein MSMEG_6363 207 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 118472511 Common - transcriptional regulator, TetR family protein MSMEG_4858 18 COG1309 AcrR, Transcriptional regulator Transcription 118473368 Common - integral membrane protein MSMEG_5066 45 COG4420 COG4420, Predicted membrane protein Function unknown 118468225 Common - transcriptional regulator MSMEG_3960 6 COG1309 AcrR, Transcriptional regulator Transcription 118472777 Common - Transposase IS116/IS110/IS902 family protein MSMEG_1732 32 None None None 118469415 Common - hypothetical protein MSMEG_1475 115 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118473091 Common - hydrolase MSMEG_3555 181 COG0388 COG0388, Predicted amidohydrolase General function prediction only 118472277 Common - hypothetical protein MSMEG_3701 6 None None None 118471290 Common - transmembrane transport protein MSMEG_2795 74 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 118472018 Common - integral membrane transporter MSMEG_3556 69 COG1953 FUI1, Cytosine/uracil/thiamine/allantoin permeases Nucleotide transport and metabolism / Coenzyme metabolism 118469631 Common - 3-isopropylmalate dehydratase large subunit MSMEG_6854 222 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 118468402 Common - IS1096, tnpA protein MSMEG_6155 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118470661 Common - membrane protein MSMEG_0814 1 COG4270 COG4270, Predicted membrane protein Function unknown 118467663 Pathogen - hypothetical protein MSMEG_6433 1 None None None 118467728 Pathogen - hypothetical protein MSMEG_2678 1 None None None 118471183 Common - hypothetical protein MSMEG_3955 24 None None None 118469479 Common - hypothetical protein MSMEG_3707 13 None None None 118469984 Common - transcriptional regulator, GntR family protein MSMEG_4057 130 COG1802 GntR, Transcriptional regulators Transcription 118473501 Common - NAD dependent epimerase/dehydratase family protein MSMEG_2956 201 COG3320 COG3320, Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 118472212 Common - transcriptional regulator, TetR family protein MSMEG_5718 113 COG1309 AcrR, Transcriptional regulator Transcription 118467910 Common - hydrolase, carbon-nitrogen family protein MSMEG_0443 197 COG0388 COG0388, Predicted amidohydrolase General function prediction only 118474025 Common - Lsr2 protein MSMEG_6092 17 None None None 118472807 Common - transcriptional regulator, IclR family protein, putative MSMEG_3335 122 COG1414 IclR, Transcriptional regulator Transcription 118470357 Common aroA 3-phosphoshikimate 1-carboxyvinyltransferase MSMEG_1890 216 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 118470202 Common - short chain dehydrogenase MSMEG_5999 232 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470210 Common - NADPH-flavin oxidoreductase MSMEG_2921 65 COG0778 NfnB, Nitroreductase Energy production and conversion 118468659 Pathogen - hypothetical protein MSMEG_2689 1 None None None 118467681 Common - probable ferredoxin/ferredoxin--NADP reductase MSMEG_5681 210 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 118470626 Common secF preprotein translocase subunit SecF MSMEG_2962 203 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 118467389 Common - hypothetical protein MSMEG_0142 2 None None None 118469450 Common - 2-deoxy-scyllo-inosamine dehydrogenase MSMEG_1370 207 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 118473636 Pathogen - hypothetical protein MSMEG_3096 1 None None None 118468447 Common - transcriptional regulator, TetR family protein MSMEG_3332 43 COG1309 AcrR, Transcriptional regulator Transcription 118473849 Common - hypothetical protein MSMEG_1195 1 COG5373 COG5373, Predicted membrane protein Function unknown 118467987 Common pcaC 4-carboxymuconolactone decarboxylase MSMEG_2604 85 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 118473667 Common - enoyl-CoA hydratase MSMEG_2229 177 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118471756 Common trpS tryptophanyl-tRNA synthetase MSMEG_1657 230 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 118471823 Common - L-ribulose-5-phosphate 4-epimerase MSMEG_1714 155 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 118468525 Common - putative serine/threonine protein kinase MSMEG_5288 47 COG2909 MalT, ATP-dependent transcriptional regulator Transcription 118469135 Common - putative monooxygenase MSMEG_1749 69 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118470235 Common - hypothetical protein MSMEG_2663 6 None None None 118470336 Common - hypothetical protein MSMEG_0887 14 None None None 118473927 Common - transcriptional regulator, GntR family protein, putative MSMEG_6639 126 COG1802 GntR, Transcriptional regulators Transcription 118472925 Pathogen pcaC 4-carboxymuconolactone decarboxylase domain protein MSMEG_2530 1 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 118472233 Pathogen - hypothetical protein MSMEG_1081 1 None None None 118467544 Common - tetrahydrofolate dehydrogenase/cyclohydrolase FolD MSMEG_1647 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 118470834 Common pyrF orotidine 5'-phosphate decarboxylase MSMEG_3048 64 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 118468732 Common - methyltransferase MSMEG_1482 23 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118473934 Common - probable transcriptional regulator, AraC family protein, putative MSMEG_6356 127 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 118468650 Common - regulatory protein, putative MSMEG_3975 6 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 118468570 Common - hypothetical protein MSMEG_1976 20 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 118467825 Pathogen - hypothetical protein MSMEG_0950 1 None None None 118472837 Common - NADH-fmn oxidoreductase MSMEG_0415 94 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 118467719 Common - MmpL protein MSMEG_4741 42 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118469936 Pathogen - hypothetical protein MSMEG_5333 1 None None None 118471687 Common - hypothetical protein MSMEG_1243 10 None None None 118468216 Common - repressor protein MSMEG_3319 33 COG1309 AcrR, Transcriptional regulator Transcription 118470245 Common - transcriptional regulator, TetR family protein MSMEG_5332 4 COG3226 COG3226, Uncharacterized protein conserved in bacteria Function unknown 118473609 Common - nudix hydrolase MSMEG_1047 41 None None None 118467980 Pathogen - hypothetical protein MSMEG_6652 1 None None None 118471266 Pathogen - hypothetical protein MSMEG_5344 1 None None None 118468414 Pathogen - hypothetical protein MSMEG_5588 1 None None None 118468707 Common - hypothetical protein MSMEG_5738 23 COG5207 UBP14, Isopeptidase T Posttranslational modification, protein turnover, chaperones 118468667 Common - putative transcriptional regulator MSMEG_1303 41 COG1396 HipB, Predicted transcriptional regulators Transcription 118471410 Common - Na+/H+ antiporter MSMEG_4682 88 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 118467945 Common thiE thiamine-phosphate pyrophosphorylase MSMEG_0789 166 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 118470640 Common - acetyl-/propionyl-coenzyme A carboxylase alpha chain MSMEG_0334 230 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 118468656 Common - transposase MSMEG_1867 28 None None None 118468062 Common - LpqU protein MSMEG_5416 17 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 118472708 Common - FHA domain protein MSMEG_0034 42 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 118467605 Common - hypothetical protein MSMEG_6059 2 None None None 118470275 Common - transcriptional regulator, LysR family protein MSMEG_4144 187 COG0583 LysR, Transcriptional regulator Transcription 118468188 Common - hypothetical protein MSMEG_4176 20 COG3832 COG3832, Uncharacterized conserved protein Function unknown 118471434 Common - NADH ubiquinone oxidoreductase, 20 kda subunit MSMEG_2720 77 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 118473603 Common - carboxymuconolactone decarboxylase MSMEG_4839 13 COG2128 COG2128, Uncharacterized conserved protein Function unknown 118473508 Pathogen - hypothetical protein MSMEG_3334 1 None None None 118473327 Common - sensor histidine kinase MSMEG_5487 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 118473340 Common - inner membrane permease YgbN MSMEG_6792 78 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 118469144 Common - enoyl-CoA hydratase MSMEG_2880 179 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118469462 Common - N-Acetyl-1-D-myo-Inosityl-2-Amino-2-Deoxy-alpha- D-Glucopyranoside Deacetylase MshB MSMEG_5129 27 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 118469002 Pathogen - hypothetical protein MSMEG_4429 1 None None None 118469507 Common miaA tRNA delta(2)-isopentenylpyrophosphate transferase MSMEG_2734 213 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 118473740 Common - MarR-family protein transcriptional regulator MSMEG_5579 40 COG1846 MarR, Transcriptional regulators Transcription 118469508 Common panE 2-dehydropantoate 2-reductase MSMEG_6374 89 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 118469096 Pathogen - hypothetical protein MSMEG_3368 1 None None None 118473352 Common - RNA polymerase sigma factor SigJ MSMEG_1666 53 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118468994 Common - hypothetical protein MSMEG_6781 2 COG5153 CVT17, Putative lipase essential for disintegration of autophagic bodies inside the vacuole Intracellular trafficking and secretion / Lipid metabolism 118470532 Common - hypothetical protein MSMEG_2261 1 COG2427 COG2427, Uncharacterized conserved protein Function unknown 118471235 Common - hypothetical protein MSMEG_0925 14 None None None 118470478 Common - nucleotidyltransferase domain protein MSMEG_4018 15 COG1708 COG1708, Predicted nucleotidyltransferases General function prediction only 118472755 Common - enoyl-CoA hydratase MSMEG_6774 178 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118469288 Common hslR heat shock protein 15 MSMEG_3455 106 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 118471516 Pathogen - hypothetical protein MSMEG_6461 1 None None None 118470589 Common - clavaldehyde dehydrogenase MSMEG_5568 235 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118473064 Common - short chain dehydrogenase MSMEG_2291 236 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118473807 Common - putative 3-hydroxyacyl-CoA dehydrogenase MSMEG_5720 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 118470486 Common - anion-transporting ATPase MSMEG_6193 49 COG0003 ArsA, Predicted ATPase involved in chromosome partitioning Cell division and chromosome partitioning 118470514 Common - hypothetical protein MSMEG_3843 6 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 118467904 Common - universal stress protein family protein MSMEG_5474 7 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 118470717 Common - N-acyl-D-aspartate deacylase MSMEG_1187 64 COG3653 COG3653, N-acyl-D-aspartate/D-glutamate deacylase Secondary metabolites biosynthesis, transport, and catabolism 118473148 Common thyX FAD-dependent thymidylate synthase MSMEG_2683 45 COG1351 THY1, Predicted alternative thymidylate synthase Nucleotide transport and metabolism 118471715 Common - universal stress protein family protein MSMEG_4362 7 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 118468383 Common - acyl-CoA dehydrogenase MSMEG_5907 135 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118467920 Common - fatty acid synthase MSMEG_4757 210 COG4982 COG4982, 3-oxoacyl- acyl-carrier protein 118467416 Common - cytosine/purines/uracil/thiamine/allantoin permease family protein MSMEG_1177 55 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 118470699 Common - hypothetical protein MSMEG_3949 1 None None None 118473552 Common - choline dehydrogenase MSMEG_0281 89 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 118470654 Common - virulence factor mce family protein MSMEG_5897 24 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118473993 Common recX recombination regulator RecX MSMEG_2724 47 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 118469469 Common - transcriptional regulator, TetR family protein MSMEG_0815 40 COG1309 AcrR, Transcriptional regulator Transcription 118469162 Common - CalR9 protein MSMEG_5250 14 None None None 118468054 Common - hypothetical protein MSMEG_1386 2 None None None 118468166 Common dinB DNA polymerase IV MSMEG_1014 185 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 118472509 Common - negative regulator of genetic competence ClpC/mecB MSMEG_6091 221 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 118467393 Common - nitrilotriacetate monooxygenase component A MSMEG_2175 56 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118473499 Pathogen - hypothetical protein MSMEG_4345 1 None None None 118469441 Common - 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_2536 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470980 Common - anti-anti-sigma factor MSMEG_6127 26 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 118467694 Common - glucosidase MSMEG_0502 54 COG1486 CelF, Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases Carbohydrate transport and metabolism 118473947 Pathogen - hypothetical protein MSMEG_1326 1 None None None 118471110 Common - zinc-binding dehydrogenase MSMEG_6108 196 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 118470582 Common - HAD-superfamily protein hydrolase, subfamily protein IIA MSMEG_2451 108 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 118473176 Common - malyl-CoA lyase MSMEG_5064 114 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 118473023 Pathogen - hypothetical protein MSMEG_2627 1 None None None 118468044 Common - transposase B MSMEG_1866 118 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 118469334 Common cofD lppg:fo 2-phospho-l-lactate transferase MSMEG_1830 39 COG0391 COG0391, Uncharacterized conserved protein Function unknown 118468595 Common - ABC transporter ATP-binding protein MSMEG_2633 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 118471497 Common - serine esterase, cutinase family protein MSMEG_5878 5 None None None 118470373 Common - MarR-family protein transcriptional regulator MSMEG_2405 54 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 118474024 Common - hypothetical protein MSMEG_5690 8 COG3832 COG3832, Uncharacterized conserved protein Function unknown 118468013 Common - Ppx/GppA phosphatase family protein MSMEG_0939 179 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 118469724 Common - putative cyclase MSMEG_3578 115 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 118470601 Common - C-5 sterol desaturase MSMEG_3666 64 COG3000 ERG3, Sterol desaturase Lipid metabolism 118470572 Common rpmE2 50S ribosomal protein L31 type B MSMEG_6070 143 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 118473909 Common - aldo/keto reductase MSMEG_2429 186 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 118469349 Common - shikimate 5-dehydrogenase MSMEG_5457 195 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 118474041 Common - hypothetical protein MSMEG_3001 5 None None None 118470285 Common - transposase MSMEG_6600 74 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 118467475 Common - two-component sensor protein MSMEG_6130 222 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 118472353 Common - 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_2548 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118472640 Common tpx thiol peroxidase MSMEG_3479 116 COG2077 Tpx, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 118472891 Common - ubiquinol-cytochrome c reductase cytochrome c subunit MSMEG_4261 29 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 118467554 Common - aconitate hydratase MSMEG_1112 223 COG1048 AcnA, Aconitase A Energy production and conversion 118472843 Common - serine esterase, cutinase family protein MSMEG_2095 3 None None None 118469184 Common - hypothetical protein MSMEG_4813 3 COG1141 Fer, Ferredoxin Energy production and conversion 118469457 Common - cyclopentanol dehydrogenase MSMEG_6709 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118468427 Common - GAF family protein MSMEG_5241 101 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 118473156 Common - allophanate hydrolase subunit 2 MSMEG_0435 115 COG1984 DUR1, Allophanate hydrolase subunit 2 Amino acid transport and metabolism 118472817 Common - hypothetical protein MSMEG_0938 9 None None None 118470673 Common - HNH endonuclease family protein MSMEG_4694 96 COG1403 McrA, Restriction endonuclease Defense mechanisms 118470978 Common - hypothetical protein MSMEG_1641 78 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 118473418 Common - oxidoreductase MSMEG_2354 70 COG0778 NfnB, Nitroreductase Energy production and conversion 118471680 Common - hypothetical protein MSMEG_0882 2 None None None 118467947 Common - chalcone/stilbene synthase family protein MSMEG_6098 44 COG5495 COG5495, Uncharacterized conserved protein Function unknown 118469934 Common nrdF ribonucleotide-diphosphate reductase subunit beta MSMEG_1033 153 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 118470067 Common - hypothetical protein MSMEG_0731 31 COG2954 COG2954, Uncharacterized protein conserved in bacteria Function unknown 118469914 Common - D-aminoacylase MSMEG_3787 63 COG3653 COG3653, N-acyl-D-aspartate/D-glutamate deacylase Secondary metabolites biosynthesis, transport, and catabolism 118472098 Common - 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_4376 230 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118473015 Common - O-methyltransferase, family protein 3 MSMEG_5003 64 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 118467790 Common - molybdopterin biosynthesis protein MSMEG_5485 162 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 118469413 Common - hypothetical protein MSMEG_3953 193 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 118470503 Common - IolD protein MSMEG_4664 221 COG3962 COG3962, Acetolactate synthase Amino acid transport and metabolism 118467430 Common - hypothetical protein MSMEG_3301 91 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118468297 Common - transcriptional regulator, TetR family protein MSMEG_0712 41 COG1309 AcrR, Transcriptional regulator Transcription 118473753 Pathogen - hypothetical protein MSMEG_1618 1 None None None 118469777 Common - hypothetical protein MSMEG_5509 11 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 118468067 Common - phenazine biosynthesis protein PhzF MSMEG_6780 80 COG0384 COG0384, Predicted epimerase, PhzC/PhzF homolog General function prediction only 118472867 Common - two-component system response regulator MSMEG_0459 89 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118473008 Common - probable sugar transporter sugar binding lipoprotein MSMEG_0515 116 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118467438 Common - 6-aminohexanoate-cyclic-dimer hydrolase MSMEG_6673 215 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 118470757 Common - zinc-binding oxidoreductase MSMEG_4442 186 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118469121 Common sun ribosomal RNA small subunit methyltransferase B MSMEG_3065 205 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 118473698 Common - hypothetical protein MSMEG_6552 1 None None None 118468824 Common argG argininosuccinate synthase MSMEG_3770 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 118473342 Common - bacterial luciferase family protein MSMEG_6621 47 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118473965 Common - adenine deaminase MSMEG_2465 12 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 118470774 Common - hypothetical protein MSMEG_6033 1 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 118472885 Common aroK shikimate kinase MSMEG_0453 80 COG3265 GntK, Gluconate kinase Carbohydrate transport and metabolism 118473013 Common - acyl-[ACP] desaturase MSMEG_5248 8 None None None 118470403 Common ybaK YbaK/ebsC protein MSMEG_1913 107 COG2606 EbsC, Uncharacterized conserved protein Function unknown 118468896 Common - membrane protein MSMEG_6140 3 None None None 118470842 Pathogen - hypothetical protein MSMEG_3161 1 None None None 118472438 Common - putative C4-dicarboxylate transporter MSMEG_5845 12 None None None 118467654 Common - acyl-CoA thioesterase MSMEG_2470 77 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 118473522 Common - para-nitrobenzyl esterase MSMEG_6303 87 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 118471608 Common - oxalate decarboxylase OxdC, putative MSMEG_2254 16 COG2140 COG2140, Thermophilic glucose-6-phosphate isomerase and related metalloenzymes Carbohydrate transport and metabolism / General function prediction only 118471631 Common - alkanesulfonate monooxygenase family protein MSMEG_2651 83 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118474036 Pathogen - hypothetical protein MSMEG_5748 1 None None None 118473617 Common recQ ATP-dependent DNA helicase RecQ MSMEG_5397 228 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 118470886 Common - integral membrane protein MSMEG_4287 19 None None None 118470071 Common - enoyl-CoA hydratase MSMEG_5276 143 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118468980 Common - transposase subunit MSMEG_4105 135 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 118472734 Common - nudix hydrolase MSMEG_0197 43 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 118469428 Common - beta-lactamase MSMEG_6872 145 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 118469336 Common - hypothetical protein MSMEG_2513 8 None None None 118471583 Common - 3-oxoacyl-ACP synthase III MSMEG_1490 180 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 118470141 Common - hypothetical protein MSMEG_4040 40 COG0778 NfnB, Nitroreductase Energy production and conversion 118470865 Common - methyltransferase, UbiE/COQ5 family protein MSMEG_1049 182 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118471973 Common - short chain dehydrogenase MSMEG_5885 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470558 Common - beta-lactamase MSMEG_6087 22 COG2367 PenP, Beta-lactamase class A Defense mechanisms 118472598 Common - TetR family protein regulatory protein MSMEG_1305 74 COG1309 AcrR, Transcriptional regulator Transcription 118473885 Pathogen - hypothetical protein MSMEG_4028 1 None None None 118471462 Common - hydrolase, nudix family protein MSMEG_4488 34 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 118473025 Common - RemK protein MSMEG_2180 28 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 118470380 Pathogen - ABC efflux pump, fused inner membrane and ATPase subunits MSMEG_2817 1 None None None 118472569 Common - catalase MSMEG_3708 48 COG0753 KatE, Catalase Inorganic ion transport and metabolism 118473188 Common - metallo-beta-lactamase superfamily protein, putative MSMEG_6278 110 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 118471611 Common - antibiotic biosynthesis monooxygenase domain protein MSMEG_6890 3 COG1359 COG1359, Uncharacterized conserved protein Function unknown 118472585 Common - hypothetical protein MSMEG_1558 2 None None None 118471638 Common - N-glycosylation MSMEG_4670 57 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 118473625 Common - D-tagatose-bisphosphate aldolase, class II, non-catalytic subunit MSMEG_0510 32 COG4573 GatZ, Predicted tagatose 6-phosphate kinase Carbohydrate transport and metabolism 118469715 Common - hypothetical protein MSMEG_4507 13 COG5450 COG5450, Transcription regulator of the Arc/MetJ class Transcription 118474053 Common - MmcI protein MSMEG_6885 25 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118470535 Pathogen - hypothetical protein MSMEG_2082 1 None None None 118467721 Common - hypothetical protein MSMEG_5334 7 None None None 118472700 Common - hypothetical protein MSMEG_0850 8 None None None 118472391 Common - sugar ABC transporter substrate-binding protein MSMEG_4658 84 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118468270 Common - hypothetical protein MSMEG_1600 4 COG3889 COG3889, Predicted solute binding protein General function prediction only 118470104 Common - secreted protein MSMEG_5107 34 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118470456 Common - response regulator receiver domain protein MSMEG_6243 49 COG3558 COG3558, Uncharacterized protein conserved in bacteria Function unknown 118473290 Common - 3-methyladenine DNA glycosylase MSMEG_3759 74 COG2094 Mpg, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 118469878 Common - hypothetical protein MSMEG_6040 1 None None None 118473376 Common - early secretory antigenic target, 6 kDa MSMEG_0066 2 COG4842 COG4842, Uncharacterized protein conserved in bacteria Function unknown 118471499 Common cobD cobalamin biosynthesis protein MSMEG_4310 149 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 118467737 Common - antigen 85-C MSMEG_3580 16 COG0627 COG0627, Predicted esterase General function prediction only 118468477 Common rpsI ribosomal protein S9 MSMEG_1557 219 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 118472434 Common - cysteine desulphurase, SufS MSMEG_4538 239 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 118470254 Common - glutamine-binding periplasmic protein/glutamine transport system permease protein MSMEG_6307 194 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 118468825 Common - short chain dehydrogenase MSMEG_0779 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118468138 Common - domain of unknown function (306) family protein MSMEG_2661 22 COG3187 HslJ, Heat shock protein Posttranslational modification, protein turnover, chaperones 118467371 Common - lignostilbene-alpha,beta-dioxygenase MSMEG_1564 36 COG3670 COG3670, Lignostilbene-alpha,beta-dioxygenase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 118470561 Common - methyltransferase MSMEG_4303 121 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 118473048 Common - probable conserved alanine rich transmembrane protein MSMEG_2764 9 None None None 118472863 Common - hypothetical protein MSMEG_6345 1 None None None 118468251 Common - carbamoyl-phosphate synthase small chain MSMEG_4726 1 None None None 118473238 Common - transporter, major facilitator family protein MSMEG_6718 123 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118469530 Common - hypothetical protein MSMEG_6192 16 None None None 118472207 Common - LAO/AO transport system ATPase MSMEG_4869 99 COG1703 ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family Amino acid transport and metabolism 118472999 Common - ribonuclease, Rne/Rng family protein MSMEG_4626 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 118473907 Common - cupin domain protein MSMEG_6861 17 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 118473986 Common ureC urease subunit alpha MSMEG_3625 96 COG0804 UreC, Urea amidohydrolase (urease) alpha subunit Amino acid transport and metabolism 118473592 Common - hypothetical protein MSMEG_4819 14 COG1141 Fer, Ferredoxin Energy production and conversion 118471622 Common ehuA ectoine/hydroxyectoine ABC transporter, ATP-binding protein MSMEG_3550 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 118472282 Common - amino acid permease-associated region MSMEG_5848 169 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118469492 Common - acyl-CoA dehydrogenase MSMEG_4118 161 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118468266 Common - NADH:flavin oxidoreductase/nadh oxidase MSMEG_2889 179 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 118473910 Pathogen - hypothetical protein MSMEG_3438 1 None None None 118471490 Common - transport integral membrane protein MSMEG_6758 134 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 118472881 Common - aminotransferase, class V superfamily protein MSMEG_0978 52 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 118469881 Common - substrate binding protein MSMEG_5574 118 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118468199 Common - hypothetical protein MSMEG_4324 26 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 118467649 Common - acyltransferase, ws/dgat/mgat subfamily protein MSMEG_5242 28 None None None 118471329 Common - phosphate/sulphate permease MSMEG_1064 156 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 118470863 Pathogen - hypothetical protein MSMEG_5327 1 None None None 118470293 Common - probable conserved integral membrane protein MSMEG_4179 12 COG3918 COG3918, Predicted membrane protein Function unknown 118472724 Common - hypothetical protein MSMEG_5108 2 None None None 118473981 Common - tRNA-dihydrouridine synthase, putative MSMEG_5774 207 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 118471732 Common - putative permease MSMEG_1186 6 COG2056 COG2056, Predicted permease General function prediction only 118472625 Pathogen - putative transmembrane protein MSMEG_0960 1 None None None 118468621 Common - hypothetical protein MSMEG_1567 5 None None None 118472564 Common - hypothetical protein MSMEG_2032 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 118473386 Common - hypothetical protein MSMEG_2592 4 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118472940 Common - regulatory protein MSMEG_4304 30 COG1396 HipB, Predicted transcriptional regulators Transcription 118473535 Common - glutaryl-CoA dehydrogenase MSMEG_6686 158 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473315 Common - glycerol operon regulatory protein MSMEG_2125 116 COG1414 IclR, Transcriptional regulator Transcription 118472193 Common - enoyl-CoA hydratase, putative MSMEG_4852 50 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118470612 Common - oxidoreductase, FAD-binding MSMEG_6382 150 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 118471336 Common - IS1096, tnpA protein MSMEG_6462 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118467481 Common - glutamine ABC transporter, ATP-binding protein MSMEG_5316 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 118473260 Pathogen - hypothetical protein MSMEG_6205 1 None None None 118470560 Common - putative acyl-CoA dehydrogenase MSMEG_4833 187 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118468557 Common - vanillin dehydrogenase MSMEG_4038 221 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118472449 Common - MmpS1 protein MSMEG_0575 1 None None None 118467949 Common - CBS domain protein MSMEG_0852 1 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 118468417 Common - transcriptional regulator, MerR family protein MSMEG_4765 22 COG0789 SoxR, Predicted transcriptional regulators Transcription 118473823 Common - hypothetical protein MSMEG_4879 53 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118473856 Common - transcriptional regulator, AraC family protein MSMEG_6839 148 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 118470054 Common - hypothetical protein MSMEG_4736 3 COG2327 WcaK, Uncharacterized conserved protein Function unknown 118468684 Common pntB NAD(P) transhydrogenase, beta subunit MSMEG_4108 123 COG1282 PntB, NAD/NADP transhydrogenase beta subunit Energy production and conversion 118470020 Common - metallo-beta-lactamase superfamily protein MSMEG_6071 5 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 118467801 Common - conserved integral membrane protein MSMEG_5537 66 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 118472105 Common - hypothetical protein MSMEG_4192 17 None None None 118471213 Common - peroxisomal trans-2-enoyl-CoA reductase MSMEG_4074 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118472601 Common pyrB aspartate carbamoyltransferase catalytic subunit MSMEG_3043 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 118468725 Common - tetracenomycin polyketide synthesis hydroxylase TcmH MSMEG_0205 12 COG3224 COG3224, Uncharacterized protein conserved in bacteria Function unknown 118473117 Common - hypothetical protein MSMEG_2922 9 None None None 118474015 Common - hypothetical protein MSMEG_6899 15 COG5650 COG5650, Predicted integral membrane protein Function unknown 118473489 Common - probable conserved integral membrane protein MSMEG_3612 4 None None None 118473439 Common - hypothetical protein MSMEG_1832 16 None None None 118467449 Common guaB inositol-5-monophosphate dehydrogenase MSMEG_1602 242 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 118470175 Common - GntR-family protein transcriptional regulator MSMEG_2104 156 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 118468764 Common - preprotein translocase subunit SecA MSMEG_3654 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 118468952 Common - cysteine dioxygenase type I superfamily protein MSMEG_5280 10 None None None 118467713 Common - putative rhamnose tranport protein, MFS family protein MSMEG_0588 59 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118467966 Common - hypothetical protein MSMEG_1289 42 None None None 118472591 Common dinP DNA polymerase IV MSMEG_6443 185 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 118471933 Common - putative transcriptional regulator MSMEG_2890 123 COG1414 IclR, Transcriptional regulator Transcription 118469108 Common - acetyl-/propionyl-coenzyme A carboxylase alpha chain MSMEG_1807 239 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 118468376 Common - peptidase C26 MSMEG_2596 131 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 118470570 Common - ftsk/spoiiie family protein MSMEG_1536 193 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 118468671 Common - IS1096, tnpA protein MSMEG_1059 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118470326 Common - hypothetical protein MSMEG_6529 2 None None None 118470647 Common - nucleotide-binding protein MSMEG_1165 107 COG1666 COG1666, Uncharacterized protein conserved in bacteria Function unknown 118471258 Common rpmB ribosomal protein L28 MSMEG_6068 158 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 118473099 Common murB UDP-N-acetylenolpyruvoylglucosamine reductase MSMEG_0928 200 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 118469796 Common - hypothetical protein MSMEG_4830 1 None None None 118473269 Common - cyclase/dehydrase family protein MSMEG_0129 6 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 118469459 Common - Fatty acid desaturase MSMEG_1211 33 COG3239 DesA, Fatty acid desaturase Lipid metabolism 118468362 Common - virulence factor mce family protein MSMEG_0349 13 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118472032 Common - hypothetical protein MSMEG_2715 7 None None None 118472956 Common - hypothetical protein MSMEG_4639 7 None None None 118472639 Common - integral membrane transport protein MSMEG_3992 125 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 118471667 Common - oxidoreductase, aldo/keto reductase family protein MSMEG_4093 192 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 118469173 Common leuB 3-isopropylmalate dehydrogenase MSMEG_2379 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 118473514 Pathogen - hypothetical protein MSMEG_4961 1 None None None 118471449 Common - hypothetical protein MSMEG_0242 1 None None None 118473129 Common - para-nitrobenzyl esterase MSMEG_3848 87 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 118467832 Common - hypothetical protein MSMEG_0079 1 None None None 118473572 Common - anthranilate dioxygenase reductase MSMEG_3594 208 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 118470565 Common - succinyl-CoA:3-ketoacid-coenzyme A transferase 1, precursor MSMEG_1898 92 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 118468241 Common - short chain dehydrogenase MSMEG_6000 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470279 Common - ABC transporter permease protein, putative MSMEG_0554 145 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 118469700 Common - 2,3-dihydroxybiphenyl 1,2-dioxygenase MSMEG_2006 37 None None None 118470881 Common - amidohydrolase 3 MSMEG_3861 93 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 118468964 Common - TetR-family protein transcriptional regulator MSMEG_1741 38 COG1309 AcrR, Transcriptional regulator Transcription 118470427 Common - hypothetical protein MSMEG_6288 1 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 118468900 Common - amidase MSMEG_1090 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 118473936 Pathogen - HPP family protein MSMEG_5561 1 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 118472262 Common - Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase MSMEG_2097 14 COG4927 COG4927, Predicted choloylglycine hydrolase General function prediction only 118468539 Pathogen - hypothetical protein MSMEG_2803 1 None None None 118471132 Common pgsA CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase MSMEG_2692 204 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 118467442 Common - oligopeptide transport ATP-binding protein AppF MSMEG_0639 249 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 118468351 Common - hypothetical protein MSMEG_0824 35 COG3571 COG3571, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 118468111 Common - transcriptional regulator, ArsR family protein MSMEG_6451 60 COG0640 ArsR, Predicted transcriptional regulators Transcription 118471187 Common - MaoC family protein MSMEG_4173 67 COG2030 MaoC, Acyl dehydratase Lipid metabolism 118468131 Common - FMN oxidoreductase MSMEG_0329 93 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 118472681 Common - oxidoreductase, Gfo/Idh/MocA family protein MSMEG_6717 173 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 118468590 Common - transcriptional regulator, ArsR family protein MSMEG_3497 36 COG0640 ArsR, Predicted transcriptional regulators Transcription 118473299 Common - alpha-ketoglutarate-dependent taurine dioxygenase MSMEG_3870 47 COG2175 TauD, Probable taurine catabolism dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 118471957 Common tylF Macrocin-O-methyltransferase MSMEG_0388 22 None None None 118469669 Common araA L-arabinose isomerase MSMEG_1715 36 COG2160 AraA, L-arabinose isomerase Carbohydrate transport and metabolism 161598320 Common - putative monovalent cation/H+ antiporter subunit A MSMEG_0848 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 118468293 Common - LppZ protein MSMEG_2369 15 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 118469652 Common - aminotransferase class-III MSMEG_0782 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 118473788 Common - DNA-binding protein MSMEG_2211 40 COG1396 HipB, Predicted transcriptional regulators Transcription 118472969 Common - amidohydrolase 2 MSMEG_1975 26 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118473111 Common - IS1096, tnpA protein MSMEG_2339 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118468927 Common - hypothetical protein MSMEG_1535 1 None None None 118472795 Pathogen - hypothetical protein MSMEG_6254 1 None None None 118469802 Common - hypothetical protein MSMEG_5481 13 COG1261 FlgA, Flagellar basal body P-ring biosynthesis protein Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 118473702 Common - glutamate permease MSMEG_2726 174 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 118473529 Common - hypothetical protein MSMEG_2779 18 None None None 118470477 Common - permease of the major facilitator superfamily protein MSMEG_5275 28 COG4760 COG4760, Predicted membrane protein Function unknown 118472492 Common - transporter, monovalent cation:proton antiporter-2 (CPA2) family protein MSMEG_3664 94 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 118473480 Common dacB D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase MSMEG_6113 97 COG2027 DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) Cell envelope biogenesis, outer membrane 118468206 Common - phosphotransferase enzyme family protein MSMEG_2554 13 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 118469620 Common - putative monooxygenase MSMEG_4344 19 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118472052 Common - lipid-transfer protein MSMEG_3844 90 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118472960 Pathogen - hypothetical protein MSMEG_4606 1 None None None 118469898 Common - N-acetylglutamate synthase MSMEG_2691 115 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 118472428 Common - NAD-dependent epimerase/dehydratase MSMEG_3470 102 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118473005 Common - oxidoreductase, aldo/keto reductase family protein MSMEG_6746 190 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 118471485 Common - acetyltransferase, GNAT family protein MSMEG_2789 26 COG0456 RimI, Acetyltransferases General function prediction only 118472608 Pathogen - hypothetical protein MSMEG_1126 1 None None None 118472308 Common - acyl-CoA dehydrogenase MSMEG_2879 157 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118470739 Common - hypothetical protein MSMEG_1434 12 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 118469678 Common - leucine-responsive regulatory protein MSMEG_1763 107 COG1522 Lrp, Transcriptional regulators Transcription 118472663 Common - ABC transporter permease MSMEG_0487 140 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 118472500 Common - integral membrane protein MSMEG_5194 80 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118467618 Common - 30S ribosomal protein S16 MSMEG_2435 213 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 118472577 Common - AMP-dependent synthetase and ligase MSMEG_2469 207 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118470288 Common - ABC transporter permease protein MSMEG_4100 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118471286 Common - calcium-binding protein MSMEG_4005 79 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 118468644 Common - DNA-binding protein MSMEG_0906 53 COG3800 COG3800, Predicted transcriptional regulator General function prediction only 118471788 Common - ABC transporter, permease protein UspE MSMEG_4467 153 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 118472054 Common - ribose transport system permease protein RbsC MSMEG_3090 109 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 118467839 Common - ATP binding protein MSMEG_6485 10 None None None 118467546 Common - major facilitator superfamily protein transporter MSMEG_6775 140 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 118470724 Common cdsA phosphatidate cytidylyltransferase MSMEG_2543 215 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 118472074 Common xth exodeoxyribonuclease III MSMEG_0829 193 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 118473830 Common - hypothetical protein MSMEG_1577 154 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 118472222 Common - oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_0258 235 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118472619 Common - methionine synthase, vitamin-B12 independent MSMEG_2359 20 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 118467424 Common - oxidoreductase MSMEG_5466 232 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471441 Common - mycobacterial family protein 11 protein MSMEG_2850 11 None None None 118470710 Common - ribose-phosphate pyrophosphokinase MSMEG_5427 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 118473837 Common - short-chain dehydrogenase/reductase SDR MSMEG_4850 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118467462 Common - hypothetical protein MSMEG_4781 1 None None None 118467573 Common - putative oxidoreductase MSMEG_1595 159 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118472740 Pathogen - hypothetical protein MSMEG_6308 1 None None None 118471015 Common - ISMsm3, transposase MSMEG_0237 10 None None None 118471202 Common - hypothetical protein MSMEG_6925 2 None None None 118470783 Common - transcriptional regulator, LysR family protein MSMEG_3972 172 COG0583 LysR, Transcriptional regulator Transcription 118473865 Common - NAD dependent epimerase/dehydratase family protein MSMEG_5985 232 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118470836 Common - hypothetical protein MSMEG_3195 7 None None None 118470185 Common ehuB ectoine/hydroxyectoine ABC transporter solute-binding protein MSMEG_3547 96 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 118468565 Common - hypothetical protein MSMEG_5268 6 COG5473 COG5473, Predicted integral membrane protein Function unknown 118471646 Common - type I modular polyketide synthase MSMEG_0408 228 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118471745 Common - universal stress protein family protein MSMEG_3950 101 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 118468280 Common - hypothetical protein MSMEG_3935 4 None None None 118468534 Common - polyketide synthase MSMEG_4513 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118473548 Pathogen - hypothetical protein MSMEG_5587 1 None None None 118469690 Common lepB signal peptidase I MSMEG_2441 168 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 118467532 Pathogen - hypothetical protein MSMEG_1590 1 None None None 118468920 Common - modification methylase, HemK family protein MSMEG_4949 219 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 118468285 Common - amidohydrolase family protein MSMEG_2994 19 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118468000 Pathogen - hypothetical protein MSMEG_2452 1 None None None 118470945 Common - [2Fe-2S] binding domain protein MSMEG_2464 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 118472848 Common - agarase MSMEG_6684 4 None None None 118473793 Pathogen - hypothetical protein MSMEG_1323 1 None None None 118473891 Common - probable monooxygenase MSMEG_4451 50 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118470791 Common - hypothetical protein MSMEG_5629 32 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 118470816 Common - putative Clp protease subunit MSMEG_3761 18 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 118467888 Pathogen - hypothetical protein MSMEG_0700 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 118470436 Common - DNA-binding protein MSMEG_5052 10 COG1396 HipB, Predicted transcriptional regulators Transcription 118473246 Pathogen - hypothetical protein MSMEG_6172 1 None None None 118467970 Common - transcriptional regulator, AraC family protein MSMEG_0307 3 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 118471071 Common - vanillate O-demethylase oxidoreductase MSMEG_4638 104 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 118472634 Common - hypothetical protein MSMEG_6240 27 COG3552 CoxE, Protein containing von Willebrand factor type A (vWA) domain General function prediction only 118467455 Common - hypothetical protein MSMEG_0613 12 COG3662 COG3662, Uncharacterized protein conserved in bacteria Function unknown 118472321 Common - ThiS family protein MSMEG_4906 42 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 118470392 Common - hypothetical protein MSMEG_0597 66 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 118470779 Common - ABC transporter ATP-binding protein MSMEG_3056 249 COG1135 AbcC, ABC-type metal ion transport system, ATPase component Inorganic ion transport and metabolism 118467611 Common - aminotransferase MSMEG_5725 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 118472361 Common - hypothetical protein MSMEG_1271 1 None None None 118473563 Common - beta-lactamase MSMEG_2658 69 COG2367 PenP, Beta-lactamase class A Defense mechanisms 118472463 Common gatA aspartyl/glutamyl-tRNA amidotransferase subunit A MSMEG_2365 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 118469104 Pathogen - hypothetical protein MSMEG_0602 1 None None None 118468105 Common - cytochrome P450 superfamily protein MSMEG_4803 67 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118474052 Common - glutamate--ammonia ligase MSMEG_5374 222 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 118467672 Common - putative methyltransferase MSMEG_5353 68 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 118469945 Common - hypothetical protein MSMEG_6464 3 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 118472456 Common - dipeptide transport ATP-binding protein DppD MSMEG_6121 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 118472782 Common - hypothetical protein MSMEG_6596 2 None None None 118472368 Common - hypothetical protein MSMEG_3141 11 None None None 118472170 Common ilvD dihydroxy-acid dehydratase MSMEG_1290 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 118470930 Common - hypothetical protein MSMEG_0355 4 None None None 118472332 Common - hypothetical protein MSMEG_1514 11 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118470110 Pathogen - hypothetical protein MSMEG_1860 1 None None None 118470675 Common - transcriptional regulator, CadC MSMEG_3297 166 COG3710 CadC, DNA-binding winged-HTH domains Transcription 118471783 Common - hypothetical protein MSMEG_4162 21 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 118469699 Common pgk phosphoglycerate kinase MSMEG_3085 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 118473730 Common - hypothetical protein MSMEG_3144 3 None None None 118468107 Common - hypothetical protein MSMEG_3869 4 None None None 118468938 Common manA mannose-6-phosphate isomerase, class I MSMEG_1836 41 COG1482 ManA, Phosphomannose isomerase Carbohydrate transport and metabolism 118473739 Common - Manganese containing catalase MSMEG_6213 46 COG3546 COG3546, Mn-containing catalase Inorganic ion transport and metabolism 118471474 Common rpmA 50S ribosomal protein L27 MSMEG_4624 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 118471676 Common acnA aconitate hydratase 1 MSMEG_3143 205 COG1048 AcnA, Aconitase A Energy production and conversion 118469659 Common - hypothetical protein MSMEG_5010 7 None None None 118472413 Pathogen - hypothetical protein MSMEG_5325 1 None None None 118472478 Common - conserved secreted protein MSMEG_5504 137 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118473393 Common - para-nitrobenzyl esterase MSMEG_0611 53 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 118470183 Common - rubredoxin MSMEG_1840 9 COG1773 COG1773, Rubredoxin Energy production and conversion 118468505 Common - hypothetical protein MSMEG_5503 1 None None None 118470122 Common - beta-lactamase MSMEG_6575 89 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 118471078 Common - pesticide degrading monooxygenase MSMEG_5001 58 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118470549 Common nagA N-acetylglucosamine-6-phosphate deacetylase MSMEG_2119 118 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 118473721 Common - transcriptional regulator, TetR family protein MSMEG_1015 9 COG1309 AcrR, Transcriptional regulator Transcription 118471372 Common tynA tyramine oxidase MSMEG_2526 22 COG3733 TynA, Cu2+-containing amine oxidase Secondary metabolites biosynthesis, transport, and catabolism 118468564 Pathogen - hypothetical protein MSMEG_5528 1 None None None 118473773 Common - major facilitator superfamily protein MFS_1 MSMEG_0827 197 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118470309 Common - hypothetical protein MSMEG_6412 14 None None None 118469976 Common - 4-hydroxybenzoyl-CoA thioesterase MSMEG_3534 44 COG0824 FcbC, Predicted thioesterase General function prediction only 118468840 Common - aldehyde dehydrogenase family protein MSMEG_0309 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118471209 Common - transcriptional regulatory protein MSMEG_6532 85 COG1309 AcrR, Transcriptional regulator Transcription 118471148 Common phnC phosphonate ABC transporter, ATP-binding protein MSMEG_0647 249 COG3638 COG3638, ABC-type phosphate/phosphonate transport system, ATPase component Inorganic ion transport and metabolism 118467703 Common cysD sulfate adenylyltransferase subunit 2 MSMEG_4979 132 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 118471946 Common - hydrolase, carbon-nitrogen family protein MSMEG_0571 199 COG0388 COG0388, Predicted amidohydrolase General function prediction only 118473498 Common carA carbamoyl phosphate synthase small subunit MSMEG_3046 233 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 118468030 Common - oxidoreductase MSMEG_4565 202 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 118468499 Common - ribonuclease Z MSMEG_4568 12 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 118471113 Common - MmpS5 protein MSMEG_0226 1 None None None 118471703 Common - oxidoreductase, zinc-binding dehydrogenase family protein MSMEG_3094 211 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 118473183 Common - ABC transporter, quaternary amine uptake transporter (QAT) family protein, substrate-binding protein MSMEG_5054 14 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 118471027 Common - cell division control protein Cdc48 MSMEG_0858 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 118472767 Common - hypothetical protein MSMEG_4202 8 COG2267 PldB, Lysophospholipase Lipid metabolism 118471154 Common - hypothetical protein MSMEG_3027 185 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 118468100 Common sthA soluble pyridine nucleotide transhydrogenase MSMEG_2748 245 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 118470115 Common - hypothetical protein MSMEG_3475 2 None None None 118468084 Common - epimerase/dehydratase MSMEG_5976 224 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118468192 Common - LprO protein MSMEG_0210 1 COG4632 EpsL, Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Carbohydrate transport and metabolism 118468094 Common - virulence factor Mce family protein MSMEG_2857 7 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118472470 Common - integral membrane protein MSMEG_4288 13 None None None 118468538 Common - hypothetical protein MSMEG_3943 14 None None None 118469062 Common - O-acyl transferase MSMEG_3429 29 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 118472325 Common - formamidase MSMEG_5335 63 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 118473678 Common clpP ATP-dependent Clp protease proteolytic subunit MSMEG_4672 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 118469187 Common - hypothetical protein MSMEG_5600 1 None None None 118469225 Common dehII haloacid dehalogenase, type II MSMEG_0115 74 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 118471782 Common - hypothetical protein MSMEG_5648 1 None None None 118468849 Common - metallo-beta-lactamase family protein MSMEG_4342 189 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 118472872 Common - ABC transporter integral membrane subunit MSMEG_0796 12 None None None 118469047 Common - steroid monooxygenase MSMEG_2894 65 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118467796 Common - proline dehydrogenase MSMEG_5117 126 COG0506 PutA, Proline dehydrogenase Amino acid transport and metabolism 118469386 Common - transcriptional regulator MSMEG_5301 48 COG1309 AcrR, Transcriptional regulator Transcription 118469069 Common - hypothetical protein MSMEG_4128 40 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118473588 Common purL phosphoribosylformylglycinamidine synthase II MSMEG_5824 234 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 118468213 Common - oxidoreductase, molybdopterin binding MSMEG_0998 95 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 118472759 Common - guanine deaminase MSMEG_1298 153 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 118470043 Common - hypothetical protein MSMEG_3385 2 None None None 118471324 Common - lactoylglutathione lyase MSMEG_6743 7 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 118468891 Common - transglycosylase associated protein MSMEG_3022 3 COG2261 COG2261, Predicted membrane protein Function unknown 118469157 Common nadC nicotinate-nucleotide pyrophosphorylase MSMEG_3201 201 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 118472388 Common - amidohydrolase family protein MSMEG_4063 42 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118470282 Common - hypothetical protein MSMEG_6649 2 None None None 118470806 Common - pe family protein MSMEG_0618 1 None None None 118471123 Common miaB tRNA-I(6)A37 thiotransferase enzyme MiaB MSMEG_2729 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 118469313 Common - short-chain type dehydrogenase/reductase MSMEG_5300 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118472164 Common - short chain dehydrogenase MSMEG_4188 237 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118469151 Common - ABC Polyamine/Opine/Phosphonate transporter, periplasmic ligand binding protein MSMEG_6524 56 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 118470997 Common - TrnB2 protein MSMEG_5901 121 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 118469150 Common - TetR-family protein transcriptional regulator MSMEG_0663 46 COG1309 AcrR, Transcriptional regulator Transcription 118473767 Common - ABC transporter, permease protein ProZ MSMEG_6331 140 COG1174 OpuBB, ABC-type proline/glycine betaine transport systems, permease component Amino acid transport and metabolism 118472219 Common - acyl-CoA synthetase MSMEG_5914 219 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118472184 Common - transcriptional regulator, GntR family protein MSMEG_0268 115 COG2188 PhnF, Transcriptional regulators Transcription 118473306 Common - ATP/GTP-binding protein MSMEG_1640 32 COG2229 COG2229, Predicted GTPase General function prediction only 118471769 Common - integral membrane protein MSMEG_5063 7 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 118471826 Common - ABC transporter ATP-binding protein MSMEG_4098 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 118471390 Common - elongation factor G MSMEG_6535 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 118469269 Common - MmcI protein MSMEG_2904 19 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118468916 Common - LacI-family protein transcriptional regulator MSMEG_6736 117 COG1609 PurR, Transcriptional regulators Transcription 118469951 Common - transcriptional regulator MSMEG_2905 143 COG1733 COG1733, Predicted transcriptional regulators Transcription 118469938 Pathogen - hypothetical protein MSMEG_0908 1 None None None 118469854 Common - tryptophan synthase subunit beta MSMEG_3309 224 COG1350 COG1350, Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) General function prediction only 118469648 Common - hypothetical protein MSMEG_4360 8 None None None 118471271 Common - peroxiredoxin Q MSMEG_3216 212 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 118467495 Common - hypothetical protein MSMEG_5035 14 None None None 118468772 Pathogen - hypothetical protein MSMEG_0112 1 None None None 118469579 Common - O-succinylbenzoate synthase MSMEG_3481 17 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 118469912 Common - hypothetical protein MSMEG_0056 1 None None None 118469468 Common - hypothetical protein MSMEG_3458 11 None None None 118471278 Common - transcriptional regulator, TetR family protein MSMEG_6503 95 COG1309 AcrR, Transcriptional regulator Transcription 118471454 Common - hypothetical protein MSMEG_0546 20 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 118470078 Common - monooxygenase MSMEG_0702 86 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118472531 Common - lipid-transfer protein MSMEG_5990 90 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118473167 Common - hemerythrin HHE cation binding domain subfamily protein, putative MSMEG_3312 11 COG5592 COG5592, Uncharacterized conserved protein Function unknown 118471024 Common - cytochrome P450 MSMEG_5853 71 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118469072 Common rpmF 50S ribosomal protein L32 MSMEG_5489 4 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 118472385 Common - hypothetical protein MSMEG_1812 2 None None None 118469303 Common - two-component system sensor kinase MSMEG_3239 10 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 118470195 Common pcaC 4-carboxymuconolactone decarboxylase domain protein MSMEG_0905 18 COG2128 COG2128, Uncharacterized conserved protein Function unknown 118472915 Common - dihydrodipicolinate reductase MSMEG_0894 36 COG4091 COG4091, Predicted homoserine dehydrogenase Amino acid transport and metabolism 118473673 Common - polysaccharide deacetylase family protein MSMEG_5728 71 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 118468380 Common - lipopolysaccharide biosynthesis acyltransferase, M MSMEG_2021 51 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 118472713 Common - peptidase, M48 family protein MSMEG_3476 24 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 118472027 Common - acyltransferase, ws/dgat/mgat subfamily protein MSMEG_3948 28 COG4908 COG4908, Uncharacterized protein containing a NRPS condensation (elongation) domain General function prediction only 118467620 Common - HesB/YadR/YfhF family protein MSMEG_4272 164 COG0316 IscA, Uncharacterized conserved protein Function unknown 118468989 Common - Fe-S protein, radical SAM family protein MSMEG_2990 103 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 118472549 Common infA translation initiation factor IF-1 MSMEG_1519 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 118468815 Common - iron-sulfur cluster-binding protein, Rieske family protein, putative MSMEG_2718 38 COG0694 COG0694, Thioredoxin-like proteins and domains Posttranslational modification, protein turnover, chaperones 118472271 Common - methylated-DNA--protein-cysteine methyltransferase MSMEG_4928 221 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 118471058 Common - hypothetical protein MSMEG_2396 5 None None None 118470457 Pathogen - hypothetical protein MSMEG_3653 1 None None None 118467851 Common - ISMsm8, transposase MSMEG_1717 64 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 118468494 Common - gaba permease MSMEG_6196 107 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 118467759 Common - hypothetical protein MSMEG_6481 11 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 118471165 Common - ABC transporter, permease protein SugA MSMEG_5060 151 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 118473275 Common coaBC bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase MSMEG_3054 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 118469619 Common - putative Lsr2 protein MSMEG_1060 3 None None None 118469980 Common - nucleotide-sugar dehydrogenase MSMEG_0475 204 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 118471384 Common - aminotransferase AlaT MSMEG_0688 240 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 118470137 Common - cytochrome P450 MSMEG_4856 75 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118467590 Common - muconolactone delta-isomerase MSMEG_4045 21 COG4829 CatC1, Muconolactone delta-isomerase Secondary metabolites biosynthesis, transport, and catabolism 118470989 Pathogen - hypothetical protein MSMEG_0201 1 None None None 118473446 Common - hypothetical protein MSMEG_5212 1 None None None 118472064 Common - cytochrome P450 MSMEG_0822 85 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118469940 Common - putative conserved integral membrane protein MSMEG_2785 4 None None None 118469959 Common - hexapeptide transferase family protein MSMEG_1055 132 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 118467776 Common - cutinase superfamily protein MSMEG_1403 2 None None None 118469301 Common - alpha,alpha-trehalose-phosphate synthase (UDP-forming) MSMEG_5892 97 COG0380 OtsA, Trehalose-6-phosphate synthase Carbohydrate transport and metabolism 118471409 Common etfA electron transfer flavoprotein, alpha subunit MSMEG_2352 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 118469908 Common - hypothetical protein MSMEG_2497 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 118469381 Common - amidohydrolase family protein MSMEG_4855 12 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118469966 Common - 3-(3-hydroxy-phenyl)propionate hydroxylase MSMEG_4866 120 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118472746 Common - transcriptional regulator, ArsR family protein MSMEG_1173 158 COG0640 ArsR, Predicted transcriptional regulators Transcription 118470485 Common - hypothetical protein MSMEG_2862 1 None None None 118471098 Common - oligopeptide transport integral membrane protein MSMEG_4542 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118468269 Common - SNF2 domain protein MSMEG_1196 70 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 118470150 Common - transcriptional regulator, TetR family protein MSMEG_2553 12 COG1309 AcrR, Transcriptional regulator Transcription 118473425 Common gltD glutamate synthase subunit beta MSMEG_6458 215 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 118470749 Pathogen - hypothetical protein MSMEG_2334 1 None None None 118473056 Common - GlcNAc-PI de-N-acetylase family protein MSMEG_5978 10 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 118469547 Common - helix-turn-helix, Fis-type, putative MSMEG_3730 67 COG3284 AcoR, Transcriptional activator of acetoin/glycerol metabolism Secondary metabolites biosynthesis, transport, and catabolism / Transcription 118472986 Pathogen - hypothetical protein MSMEG_2917 1 None None None 118471120 Common - 2-deoxy-D-gluconate 3-dehydrogenase MSMEG_3379 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118472339 Common - transcriptional accessory protein MSMEG_2839 138 COG2183 Tex, Transcriptional accessory protein Transcription 118467896 Common - enoyl-CoA hydratase MSMEG_2227 177 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118472880 Common - hypothetical protein MSMEG_6569 80 COG2847 COG2847, Uncharacterized protein conserved in bacteria Function unknown 118471846 Common - D-aminopeptidase MSMEG_1507 44 COG3191 DmpA, L-aminopeptidase/D-esterase Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118468451 Common ndk nucleoside diphosphate kinase MSMEG_4627 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 118470243 Common pstB phosphate ABC transporter, ATP-binding protein MSMEG_5779 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 118467568 Pathogen - hypothetical protein MSMEG_3540 1 None None None 118472192 Common - conserved hypothetical protein TIGR00026 MSMEG_5030 11 None None None 118470312 Common - aliphatic sulfonate binding protein MSMEG_3852 81 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 118468467 Common - amino acid permease superfamily protein MSMEG_2525 73 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118467628 Common - hypothetical protein MSMEG_4221 162 COG1496 COG1496, Uncharacterized conserved protein Function unknown 118469363 Common - integral membrane protein MSMEG_4408 28 COG3059 COG3059, Predicted membrane protein Function unknown 118469310 Common gltX glutamyl-Q tRNA(Asp) synthetase MSMEG_6306 242 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 118472252 Common - MscS Mechanosensitive ion channel MSMEG_5496 44 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 118472778 Common menB naphthoate synthase MSMEG_1075 176 COG0447 MenB, Dihydroxynaphthoic acid synthase Coenzyme metabolism 118472551 Common - acyl-CoA dehydrogenase domain protein MSMEG_4097 67 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472947 Common - arylsulfatase MSMEG_1451 74 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 118472698 Common - P450 heme-thiolate protein MSMEG_5995 74 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118468919 Common - hypothetical protein MSMEG_2955 5 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 118468186 Pathogen - hypothetical protein MSMEG_2555 1 None None None 118472312 Common - ftsk/spoiiie family protein MSMEG_0061 194 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 118468142 Common - putative acyl-CoA dehydrogenase MSMEG_6016 127 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473486 Pathogen - hypothetical protein MSMEG_3966 1 None None None 118470205 Common - hypothetical ABC transporter ATP-binding protein MSMEG_6554 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 118473044 Pathogen - hypothetical protein MSMEG_3052 1 None None None 118468061 Common - hypothetical protein MSMEG_2192 2 COG3283 TyrR, Transcriptional regulator of aromatic amino acids metabolism Transcription / Amino acid transport and metabolism 118470465 Common - [NADP+] succinate-semialdehyde dehydrogenase MSMEG_2488 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118472101 Common - radical SAM enzyme, Cfr family protein MSMEG_2545 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 118469517 Common - glyoxalase family protein MSMEG_5027 52 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 118470466 Common - hypothetical protein MSMEG_2068 1 None None None 118471721 Common - 4Fe-4S binding domain protein MSMEG_5433 70 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 118467827 Common cobM precorrin-4 C11-methyltransferase MSMEG_3877 203 COG2875 CobM, Precorrin-4 methylase Coenzyme metabolism 118468520 Common - sensor histidine kinase MSMEG_1918 117 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 118472231 Common - flavoprotein involved in K+ transport MSMEG_0569 57 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118472670 Common - transcriptional regulator, CdaR, putative MSMEG_4006 10 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 118470108 Common - ATPase associated with various cellular activities MSMEG_4583 100 COG0714 COG0714, MoxR-like ATPases General function prediction only 118469787 Common - membrane protein MSMEG_5644 33 COG1511 COG1511, Predicted membrane protein Function unknown 118472204 Common - ABC transporter, ATP-binding protein MSMEG_0211 243 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 118469846 Pathogen - hypothetical protein MSMEG_2832 1 None None None 118470353 Common - hypothetical protein MSMEG_3337 2 None None None 118470614 Common - transcriptional regulator MSMEG_6344 149 COG1733 COG1733, Predicted transcriptional regulators Transcription 118472316 Common - GatB/Yqey domain protein MSMEG_6214 144 COG1610 COG1610, Uncharacterized conserved protein Function unknown 118468944 Pathogen - hypothetical protein MSMEG_5361 1 None None None 118470530 Common - cytidine/deoxycytidylate deaminase, zinc-binding region MSMEG_3575 137 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 118470780 Pathogen - hypothetical protein MSMEG_5293 1 None None None 118473146 Common - S30AE family protein MSMEG_1878 83 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 118467606 Common - propanediol utilization: dehydratase, medium subunit MSMEG_1548 13 None None None 118472016 Common - tetracyclin repressor, C- all-alpha domain protein MSMEG_0442 31 COG1309 AcrR, Transcriptional regulator Transcription 118468912 Common - serine/threonine protein kinase MSMEG_0786 130 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 118470135 Common - proteasome component MSMEG_3890 16 None None None 118468070 Common - hypothetical protein MSMEG_5309 10 COG2345 COG2345, Predicted transcriptional regulator Transcription 118472238 Common - fumarylacetoacetate hydrolase family protein MSMEG_2478 177 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 118468164 Pathogen - hypothetical protein MSMEG_4602 1 None None None 118471185 Common - hypothetical protein MSMEG_6325 11 None None None 118472521 Common - hypothetical protein MSMEG_6499 35 COG2343 COG2343, Uncharacterized protein conserved in bacteria Function unknown 118469823 Common - alkylphosphonate uptake protein MSMEG_1302 2 None None None 118467973 Pathogen - hypothetical protein MSMEG_3446 1 None None None 118468844 Common - MarR family protein transcriptional regulatory protein MSMEG_2476 11 COG1846 MarR, Transcriptional regulators Transcription 118471602 Common - hypothetical protein MSMEG_4200 189 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 118472933 Common - hypothetical protein MSMEG_2559 15 COG1141 Fer, Ferredoxin Energy production and conversion 118473520 Common - hypothetical protein MSMEG_1066 7 None None None 118470857 Common hisC histidinol-phosphate aminotransferase MSMEG_3206 230 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 118473608 Common mgtE magnesium transporter MSMEG_6269 176 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 118473814 Common - hydrolase MSMEG_3810 199 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 118467687 Common - metallopeptidase MSMEG_0234 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 118469999 Common - phosphonoacetaldehyde hydrolase MSMEG_4401 63 COG0546 Gph, Predicted phosphatases General function prediction only 118470548 Pathogen - hypothetical protein MSMEG_1022 1 None None None 118468081 Common - acetyltransferase MSMEG_4439 91 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 118470802 Common - phosphoglycerate mutase family protein MSMEG_0970 40 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 118471508 Common - tRNA adenylyltransferase MSMEG_6926 213 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 118472558 Common coaD phosphopantetheine adenylyltransferase MSMEG_2414 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 118471956 Common - bifunctional coenzyme PQQ synthesis protein C/D MSMEG_3722 10 None None None 118469837 Common - aldehyde dehydrogenase MSMEG_6297 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118471342 Common - PAP2 superfamily protein MSMEG_0634 3 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 118473976 Common - hypothetical protein MSMEG_3196 1 None None None 118472904 Common - transcriptional regulator, TetR family protein MSMEG_6564 45 COG1309 AcrR, Transcriptional regulator Transcription 118471909 Common - transcriptional regulator, AraC family protein MSMEG_4601 69 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 118471902 Pathogen - hypothetical protein MSMEG_2831 1 None None None 118467730 Common - [NiFe] hydrogenase, delta subunit, putative MSMEG_3929 45 COG1941 FrhG, Coenzyme F420-reducing hydrogenase, gamma subunit Energy production and conversion 118473339 Common - hypothetical protein MSMEG_3570 6 COG1289 COG1289, Predicted membrane protein Function unknown 118470851 Common ubiE ubiquinone/menaquinone biosynthesis methyltransferase MSMEG_1115 217 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118468753 Common - hypothetical protein MSMEG_2333 10 COG1520 COG1520, FOG: WD40-like repeat Function unknown 118469895 Pathogen - hypothetical protein MSMEG_6348 1 None None None 118471367 Common - ABC transporter, permease protein MSMEG_6669 176 COG4132 COG4132, ABC-type uncharacterized transport system, permease component General function prediction only 118473874 Common trpB tryptophan synthase subunit beta MSMEG_3220 224 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 118467866 Common - hypothetical protein MSMEG_0253 2 None None None 118473584 Common - hypothetical protein MSMEG_1754 3 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 118469447 Common - hypothetical protein MSMEG_6025 6 None None None 118473815 Common - hypothetical protein MSMEG_5927 5 None None None 118473396 Pathogen - hypothetical protein MSMEG_1632 1 None None None 118469057 Common - carbohydrate kinase family protein MSMEG_1573 214 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 118472351 Common - hypothetical protein MSMEG_2787 14 COG1985 RibD, Pyrimidine reductase, riboflavin biosynthesis Coenzyme metabolism 118469863 Pathogen - hypothetical protein MSMEG_4526 1 None None None 118467504 Common - virulence factor Mce family protein MSMEG_2855 6 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118468175 Common - transcriptional regulator, GntR family protein MSMEG_0130 127 COG1802 GntR, Transcriptional regulators Transcription 118473132 Common - flavoprotein disulfide reductase MSMEG_1735 242 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 118470037 Common - hypothetical protein MSMEG_5902 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 118469585 Common - hypothetical protein MSMEG_4802 14 COG1141 Fer, Ferredoxin Energy production and conversion 118469766 Pathogen - flagella membrane glycoprotein 1B, putative MSMEG_4994 1 None None None 118469433 Common - integral membrane transport protein MSMEG_2911 119 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118471251 Common - regulatory protein MSMEG_3997 8 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 118470152 Common - virulence factor MSMEG_0346 6 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118468883 Common - integral membrane protein MSMEG_0403 2 None None None 118467806 Common - hypothetical protein MSMEG_5958 2 None None None 118469142 Common - glycosyl transferase, family protein 39 MSMEG_0627 17 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 118472273 Common - two-component system regulator MSMEG_0981 150 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118467756 Common - hypothetical protein MSMEG_6005 2 None None None 118467556 Common - hypothetical protein MSMEG_4496 101 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 118468759 Common - ATP-dependent DNA helicase RecQ MSMEG_5399 173 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 118467736 Common - transcriptional regulator, TetR family protein MSMEG_4024 17 COG1309 AcrR, Transcriptional regulator Transcription 118471297 Common - putative transposase MSMEG_4132 7 None None None 118471908 Common - peptidase S1 and S6, chymotrypsin/Hap MSMEG_5486 221 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 118469272 Common - glycosyl hydrolase, family protein 57 MSMEG_2349 35 COG1543 COG1543, Uncharacterized conserved protein Function unknown 118471988 Common - IS1096, tnpR protein MSMEG_2002 44 None None None 118474007 Common - hypothetical protein MSMEG_4257 5 None None None 118472859 Common tynA tyramine oxidase MSMEG_3847 22 COG3733 TynA, Cu2+-containing amine oxidase Secondary metabolites biosynthesis, transport, and catabolism 118469487 Common - hypothetical protein MSMEG_4738 2 None None None 118473373 Common - transcriptional regulator, TetR family protein MSMEG_6628 18 COG1309 AcrR, Transcriptional regulator Transcription 118470493 Common - thioredoxin reductase MSMEG_1516 246 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 118468341 Common - HNH endonuclease domain protein MSMEG_3404 5 None None None 118469220 Pathogen - hypothetical protein MSMEG_6534 1 None None None 118471852 Common - acyl-CoA synthetase MSMEG_6393 197 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118469609 Pathogen - hypothetical protein MSMEG_3866 1 None None None 118468877 Common - hypothetical protein MSMEG_5877 9 COG3934 COG3934, Endo-beta-mannanase Carbohydrate transport and metabolism 118469858 Common - cytochrome aa3 controlling protein MSMEG_3117 18 COG1612 CtaA, Uncharacterized protein required for cytochrome oxidase assembly Posttranslational modification, protein turnover, chaperones 118471007 Pathogen - hypothetical protein MSMEG_5112 1 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 118467517 Common pdxH pyridoxamine 5'-phosphate oxidase MSMEG_5675 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 118467559 Common - conserved secreted protein MSMEG_4056 30 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118469295 Common - LysR-family protein transcriptional regulator MSMEG_3840 188 COG0583 LysR, Transcriptional regulator Transcription 118469473 Common - LacI family protein transcriptional regulator MSMEG_2989 128 COG1609 PurR, Transcriptional regulators Transcription 118473229 Common - hypothetical protein MSMEG_6090 12 None None None 118470709 Common regX3 DNA-binding response regulator RegX3 MSMEG_0937 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 118468949 Common - acetyl-/propionyl-coenzyme A carboxylase alpha chain MSMEG_4716 225 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 118468527 Common - acyl-CoA dehydrogenase MSMEG_3668 50 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472046 Common - hypothetical protein MSMEG_1027 82 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118467467 Common - xanthine dehydrogenase MSMEG_0743 116 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 118467848 Common - rhomboid family protein MSMEG_5036 172 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 118472930 Common - esterase MSMEG_0267 124 COG0657 Aes, Esterase/lipase Lipid metabolism 118471307 Common rpmC 50S ribosomal protein L29 MSMEG_1444 145 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 118469751 Common - integral membrane protein MSMEG_0513 3 COG2510 COG2510, Predicted membrane protein Function unknown 118472876 Common - phosphatase YfbT MSMEG_1707 110 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 118469867 Common - 4-hydroxy-2-ketovalerate aldolase MSMEG_5937 192 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 118469294 Common gcl glyoxylate carboligase MSMEG_5476 221 COG3960 COG3960, Glyoxylate carboligase General function prediction only 118468088 Common rocD ornithine--oxo-acid transaminase MSMEG_1413 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 118473459 Pathogen - glucose-6-phosphate isomerase, putative MSMEG_2114 1 COG2140 COG2140, Thermophilic glucose-6-phosphate isomerase and related metalloenzymes Carbohydrate transport and metabolism / General function prediction only 118473083 Common - integral membrane protein MSMEG_5788 3 None None None 118471305 Common - methylenetetrahydrofolate reductase family protein, putative MSMEG_6664 20 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 118467536 Common - oxidoreductase MSMEG_4685 55 COG3491 PcbC, Isopenicillin N synthase and related dioxygenases General function prediction only 118471245 Common - hypothetical protein MSMEG_1537 1 None None None 118471671 Pathogen - hypothetical protein MSMEG_3712 1 None None None 118467359 Common - YghA protein MSMEG_1845 105 COG2860 COG2860, Predicted membrane protein Function unknown 118473213 Common - HNH endonuclease MSMEG_5583 6 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 118468304 Common rplW 50S ribosomal protein L23 MSMEG_1438 123 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 118470264 Common - hypothetical protein MSMEG_5865 6 None None None 118472237 Common - ABC transporter, permease protein MSMEG_6726 22 COG4721 COG4721, Predicted membrane protein Function unknown 118468404 Common - mitomycin radical oxidase MSMEG_1964 55 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 118472451 Common - hypothetical protein MSMEG_1393 2 None None None 118471022 Common - CaiB/BaiF family protein MSMEG_6773 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118470700 Common - alcohol dehydrogenase MSMEG_6833 164 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 118472142 Common - permease, cytosine/purines, uracil, thiamine, allantoin family protein MSMEG_2972 74 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 118468873 Common - cell cycle protein, FtsW/RodA/SpoVE family protein MSMEG_0032 206 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 118470915 Common - [NADP+] succinate-semialdehyde dehydrogenase MSMEG_5538 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118471141 Common - sensor histidine kinase MSMEG_5158 107 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 118471534 Pathogen - hypothetical protein MSMEG_1450 1 None None None 118472048 Common - alkylhydroperoxidase AhpD MSMEG_3956 4 None None None 118471994 Common - regulatory protein MSMEG_5206 37 COG1309 AcrR, Transcriptional regulator Transcription 118471400 Common - 50S ribosomal protein L17 MSMEG_1525 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 118468488 Common - GTP cyclohydrolase II MSMEG_2318 26 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 118469128 Common metG methionyl-tRNA synthetase MSMEG_5441 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 118470905 Common - phosphatidylethanolamine-binding protein MSMEG_6851 82 COG1881 COG1881, Phospholipid-binding protein General function prediction only 118469472 Common - cytochrome P450 107B1 MSMEG_3134 90 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118468857 Common - taurine import ATP-binding protein TauB MSMEG_1234 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 118471318 Common - 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_4169 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470964 Common - ABC-type transporter, substrate binding protein MSMEG_4101 168 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 118469758 Common - TnpC protein MSMEG_4127 6 None None None 118468470 Common - AMP-dependent synthetase and ligase MSMEG_4883 225 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118473833 Common eutC ethanolamine ammonia-lyase small subunit MSMEG_1554 52 COG4302 EutC, Ethanolamine ammonia-lyase, small subunit Amino acid transport and metabolism 118470578 Common - antibiotic biosynthesis monooxygenase MSMEG_1979 10 COG1359 COG1359, Uncharacterized conserved protein Function unknown 118472483 Common thiS sulfur carrier protein ThiS MSMEG_0792 14 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 118473925 Common - membrane transport protein MSMEG_3283 58 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118468398 Common - proton antiporter efflux pump MSMEG_6225 165 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118473458 Common - phospholipase D family protein MSMEG_0375 47 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 118471388 Common - hypothetical protein MSMEG_6525 1 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 118469005 Common - hypothetical protein MSMEG_4102 6 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473757 Common - alpha-methylacyl-CoA racemase, putative MSMEG_5184 115 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118472649 Common - shikimate transporter MSMEG_0483 142 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 118469357 Common - hypothetical protein MSMEG_6504 10 None None None 118472748 Common pcaC 4-carboxymuconolactone decarboxylase domain protein MSMEG_5814 37 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 118469232 Common nrdF ribonucleotide-diphosphate reductase subunit beta MSMEG_2313 153 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 118471913 Common - ABC transporter ATP-binding protein MSMEG_5102 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 118471790 Common - gnat-family protein acetyltransferase MSMEG_2593 71 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 118469943 Common - oxidoreductase, electron transfer component MSMEG_6039 125 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 118469281 Pathogen - hypothetical protein MSMEG_4037 1 None None None 118467403 Common topA DNA topoisomerase I MSMEG_6157 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 118467919 Pathogen - hypothetical protein MSMEG_0910 1 None None None 118468503 Common - alkanesulfonate monooxygenase family protein MSMEG_3850 74 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118469919 Pathogen - hypothetical protein MSMEG_6211 1 None None None 118468614 Pathogen - hypothetical protein MSMEG_4499 1 None None None 118471313 Common - caib/baif family protein MSMEG_6294 115 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118469088 Common - copper resistance protein CopC MSMEG_6436 27 COG2372 CopC, Uncharacterized protein, homolog of Cu resistance protein CopC General function prediction only 118469358 Common - hypothetical protein MSMEG_3436 32 COG4185 COG4185, Uncharacterized protein conserved in bacteria Function unknown 118467514 Common - isochorismate synthase DhbC MSMEG_1925 223 COG1169 MenF, Isochorismate synthase Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118472496 Common ilvE branched-chain amino acid aminotransferase MSMEG_4276 206 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 118473350 Common - hypothetical protein MSMEG_5411 3 None None None 118469408 Common - Periplasmic binding protein MSMEG_0438 62 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 118468833 Common - prophage Lp1 protein 5 MSMEG_1264 8 None None None 118469267 Common - enoyl-CoA hydratase MSMEG_4077 183 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118473991 Common - major facilitator superfamily protein MFS_1 MSMEG_1320 187 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118468458 Common cobH precorrin-8X methylmutase MSMEG_3872 118 COG2082 CobH, Precorrin isomerase Coenzyme metabolism 118467526 Common radA DNA repair protein RadA MSMEG_6079 217 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 118473716 Common - tetracenomycin polyketide synthesis O-methyltransferase TcmP MSMEG_6473 36 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118473464 Common - putative transposase MSMEG_4156 34 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 118469566 Common - hypothetical protein MSMEG_5591 25 COG4195 COG4195, Phage-related replication protein General function prediction only 118473103 Common - glucose-1-dehydrogenase MSMEG_4419 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470976 Pathogen - hypothetical protein MSMEG_6620 2 None None None 118467414 Common - hypothetical protein MSMEG_5997 2 None None None 118473997 Common - integral membrane protein MSMEG_1505 54 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 118472980 Common glmU UDP-N-acetylglucosamine pyrophosphorylase MSMEG_5426 229 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 118471695 Common - S-(hydroxymethyl)glutathione dehydrogenase MSMEG_6616 202 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 118471488 Common - phosphohydrolase MSMEG_1061 45 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 118473969 Common - putative monooxygenase MSMEG_4095 48 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118471237 Common - glutamate synthase family protein MSMEG_6263 191 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 118468385 Common - acetyltransferase MSMEG_0187 50 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 118468253 Common - 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_1071 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118468776 Common - cyclase MSMEG_3991 90 COG1878 COG1878, Predicted metal-dependent hydrolase General function prediction only 118469004 Common - PAP2 superfamily protein MSMEG_6402 5 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 118473532 Common - probable conserved integral membrane alanine and leucine rich protein MSMEG_2770 17 None None None 118469041 Common - enoyl-CoA hydratase MSMEG_2641 181 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118472659 Common - racemase MSMEG_0489 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118473979 Common - hypothetical protein MSMEG_2143 1 None None None 118470809 Common - short-chain dehydrogenase/reductase SDR MSMEG_2872 234 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118472883 Pathogen - hypothetical protein MSMEG_0541 1 None None None 118470295 Common - short-chain dehydrogenase/reductase SDR MSMEG_5234 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118473806 Common - mur ligase family protein MSMEG_6276 47 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 118472442 Pathogen - hypothetical protein MSMEG_2801 1 None None None 118470454 Common - transcriptional regulator, TetR family protein MSMEG_1355 22 COG1309 AcrR, Transcriptional regulator Transcription 118473742 Common - pentachlorophenol 4-monooxygenase MSMEG_1699 154 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118470324 Common - virulence factor Mce family protein MSMEG_5900 6 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118468730 Common - TetR-family protein transcriptional regulator MSMEG_4022 68 COG1309 AcrR, Transcriptional regulator Transcription 118467939 Common - hypothetical protein MSMEG_5520 94 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118471613 Common - transcriptional regulator, Crp/Fnr family protein MSMEG_0539 171 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 118473554 Common - hypothetical protein MSMEG_3331 1 None None None 118471521 Common - hypothetical protein MSMEG_2582 7 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 118469505 Common - transcriptional regulator, PadR family protein MSMEG_2868 17 COG1695 COG1695, Predicted transcriptional regulators Transcription 118470488 Common - hypothetical protein MSMEG_0940 1 None None None 118470529 Common - choline dehydrogenase MSMEG_3431 81 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 118467902 Common hemG protoporphyrinogen oxidase MSMEG_2781 56 COG1232 HemY, Protoporphyrinogen oxidase Coenzyme metabolism 118472753 Common - ABC proline/glycine betaine family protein transporter, periplasmic ligand binding protein MSMEG_5163 49 COG2113 ProX, ABC-type proline/glycine betaine transport systems, periplasmic components Amino acid transport and metabolism 118468009 Common - nitroreductase family protein MSMEG_6627 2 COG0778 NfnB, Nitroreductase Energy production and conversion 118467930 Common - hypothetical protein MSMEG_6860 4 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 118470044 Common - 3-isopropylmalate dehydratase small subunit MSMEG_2504 78 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 118471197 Common rho transcription termination factor Rho MSMEG_4954 213 COG1158 Rho, Transcription termination factor Transcription 118467391 Common - efflux membrane protein MSMEG_5670 219 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118470539 Common - MarR-family protein transcriptional regulator MSMEG_1330 33 COG1846 MarR, Transcriptional regulators Transcription 118471514 Common - glycosyl hydrolase family protein 76 MSMEG_0740 9 COG4833 COG4833, Predicted glycosyl hydrolase Carbohydrate transport and metabolism 118468092 Common - band 7 protein MSMEG_3155 219 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 118469741 Common - hypothetical protein MSMEG_0975 69 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 118471594 Common - acyl-CoA synthetase MSMEG_3767 77 COG3243 PhaC, Poly(3-hydroxyalkanoate) synthetase Lipid metabolism 118473227 Common - putative secreted protein MSMEG_4352 5 None None None 118471943 Pathogen - hypothetical protein MSMEG_2031 1 None None None 118473124 Common - sugar phosphate isomerase/epimerase MSMEG_2005 37 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 118471468 Common - resuscitation-promoting factor RpfB MSMEG_5439 28 COG3583 COG3583, Uncharacterized protein conserved in bacteria Function unknown 118470588 Common rfbA glucose-1-phosphate thymidylyltransferase MSMEG_0384 233 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 118471892 Pathogen - pp24 protein MSMEG_0522 1 None None None 118473949 Common - transcriptional regulatory protein MSMEG_6293 34 COG1309 AcrR, Transcriptional regulator Transcription 118469537 Common - short chain dehydrogenase MSMEG_5544 238 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118471357 Common - hypothetical protein MSMEG_5090 2 None None None 118468042 Common - LpqG protein MSMEG_6109 74 COG2968 COG2968, Uncharacterized conserved protein Function unknown 118467700 Common - xanthine/uracil permease MSMEG_2570 127 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 118470684 Common - conserved hypothetical proline rich protein MSMEG_4349 156 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 118469572 Common - extracellular solute-binding protein, family protein 1 MSMEG_3111 98 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118472799 Common - antar domain protein MSMEG_5554 15 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 118473325 Common - abortive infection protein MSMEG_6420 24 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 118469429 Pathogen - hypothetical protein MSMEG_5750 1 None None None 118472144 Pathogen - hypothetical protein MSMEG_1259 1 None None None 118469038 Common - cobyric acid synthase MSMEG_6277 80 COG3442 COG3442, Predicted glutamine amidotransferase General function prediction only 118467488 Common - acyltransferase, ws/dgat/mgat subfamily protein MSMEG_1882 28 None None None 118468581 Common - peptidase, M24 family protein MSMEG_4854 208 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 118473403 Common - transcriptional regulator, GntR family protein MSMEG_0124 139 COG2186 FadR, Transcriptional regulators Transcription 118468739 Common - probable forkhead-associated protein MSMEG_1634 1 None None None 118470471 Common - DNA-binding response regulator MSMEG_4990 210 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 118472829 Common cobA uroporphyrin-III C-methyltransferase MSMEG_2618 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 118468079 Common - IS1096, tnpA protein MSMEG_5094 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118473694 Common - putative oxidoreductase YdbC MSMEG_2475 163 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 118468984 Common - acyl-CoA synthetase MSMEG_4731 206 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118473574 Common - polysaccharide deacetylase family protein MSMEG_1318 103 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 118469422 Common - glutamine amidotransferase MSMEG_6691 138 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 118472841 Common - oxidoreductase MSMEG_1566 64 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118470218 Common - hypothetical protein MSMEG_1358 10 None None None 118473954 Common - pyridoxamine 5'-phosphate oxidase family protein MSMEG_3179 5 None None None 118468026 Common - hypothetical protein MSMEG_5251 3 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118467524 Common - carrier protein MSMEG_4611 22 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 118470075 Common - 2-nitropropane dioxygenase, NPD MSMEG_0992 118 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 118469874 Common - hydrolase, alpha/beta fold family protein MSMEG_1940 87 COG2267 PldB, Lysophospholipase Lipid metabolism 118473286 Common - acetyl-CoA acetyltransferase MSMEG_5923 90 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118474043 Common - hypothetical protein MSMEG_0287 12 COG4341 COG4341, Predicted HD phosphohydrolase General function prediction only 118470563 Common - cutinase MSMEG_1528 3 None None None 118469098 Pathogen - hypothetical protein MSMEG_2827 1 None None None 118468248 Common - cytochrome C biogenesis protein transmembrane region MSMEG_3541 6 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 118472642 Common - TrkB protein MSMEG_2769 160 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 118469067 Common - zinc-binding alcohol dehydrogenase MSMEG_4064 131 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118469831 Common - hypothetical protein MSMEG_0439 80 COG2855 COG2855, Predicted membrane protein Function unknown 118473158 Common prfB peptide chain release factor 2 MSMEG_2086 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 118472000 Pathogen - hypothetical protein MSMEG_6707 1 None None None 118471560 Common - D-alanyl-D-alanine carboxypeptidase MSMEG_2432 125 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 118473970 Common trxB thioredoxin-disulfide reductase MSMEG_6933 246 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 118467376 Pathogen - hypothetical protein MSMEG_1454 1 None None None 118471884 Common - lipoprotein MSMEG_5017 44 COG3544 COG3544, Uncharacterized protein conserved in bacteria Function unknown 118469032 Common - transcriptional regulator, TetR family protein MSMEG_2030 87 COG1309 AcrR, Transcriptional regulator Transcription 118468654 Common - 3-ketosteroid-delta-1-dehydrogenase MSMEG_4864 67 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 118471260 Common - hypothetical protein MSMEG_0537 6 None None None 118469456 Common - permease, cytosine/purines, uracil, thiamine, allantoin family protein MSMEG_6660 42 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 118471227 Common - hypothetical protein MSMEG_0341 43 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118470083 Common - dehydrogenase MSMEG_6557 129 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118467506 Common - glycosyl transferase, group 2 family protein MSMEG_6367 15 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 118471839 Common - LysR-family protein transcriptional regulator MSMEG_6840 72 COG0583 LysR, Transcriptional regulator Transcription 118467818 Common - enoyl-CoA hydratase/isomerase family protein MSMEG_4020 178 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118468710 Pathogen - hypothetical protein MSMEG_5459 1 None None None 118471109 Common - ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components MSMEG_1373 110 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 118468728 Common - acyltransferase, ws/dgat/mgat subfamily protein MSMEG_4297 28 None None None 118472513 Common purQ phosphoribosylformylglycinamidine synthase subunit I MSMEG_5831 224 COG0047 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain Nucleotide transport and metabolism 118469769 Common - enoyl-CoA hydratase MSMEG_2047 182 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118472802 Common - amino acid permease-associated region MSMEG_0499 69 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118467351 Common - hypothetical protein MSMEG_2562 1 None None None 118471200 Common - hypothetical protein MSMEG_4187 40 COG5361 COG5361, Uncharacterized conserved protein Function unknown 118468318 Common - aminotransferase, class V family protein MSMEG_6591 90 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 118472210 Common - carbonic anhydrase MSMEG_4985 55 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 118468209 Common - transposase, Mutator family protein MSMEG_4154 82 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 118469633 Common fabG 3-oxoacyl-(acyl-carrier-protein) reductase MSMEG_3150 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118473503 Common - virulence factor Mce family protein MSMEG_4793 18 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118471874 Common rdgB non-canonical purine NTP pyrophosphatase, RdgB/HAM1 family protein MSMEG_4899 237 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 118472805 Common - transcriptional regulatory protein MSMEG_5784 197 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 118472125 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase MSMEG_2206 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118473207 Common - DNA-binding protein MSMEG_2428 41 COG1396 HipB, Predicted transcriptional regulators Transcription 118468863 Common - ISMsm5, transposase MSMEG_6589 52 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 118470005 Pathogen - hypothetical protein MSMEG_2324 1 None None None 118470511 Common - penicillin-binding protein 4 MSMEG_5637 122 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 118471177 Common - fructose-1,6-bisphosphate aldolase MSMEG_3507 32 COG3588 COG3588, Fructose-1,6-bisphosphate aldolase Carbohydrate transport and metabolism 118470628 Common - thiopurine S-methyltransferase (tpmt) superfamily protein MSMEG_2539 18 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 118473093 Common - binding protein dependent transport protein MSMEG_5146 147 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 118470405 Common - lipoprotein LpqH MSMEG_6315 2 None None None 118470088 Common rplD 50S ribosomal protein L4 MSMEG_1437 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 118470727 Common - regulatory protein, DeoR MSMEG_3115 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 118472653 Common - SN-glycerol-3-phosphate ABC transporter, ATP-binding protein MSMEG_3270 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 118469028 Pathogen - hypothetical protein MSMEG_0652 1 None None None 118471042 Common - 3'(2'),5'-bisphosphate nucleotidase, putative MSMEG_4977 132 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 118473336 Common lspA lipoprotein signal peptidase MSMEG_3174 44 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 118467665 Common nuoG NADH dehydrogenase subunit G MSMEG_2057 196 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 118470341 Common - ABC transporter permease protein MSMEG_4099 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118471150 Common - hypothetical protein MSMEG_1780 101 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 118472813 Common rpsA 30S ribosomal protein S1 MSMEG_3833 225 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 118470016 Common - two-component sensor histidine kinase MSMEG_1515 215 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 118468854 Common - oxidoreductase MSMEG_3318 74 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118473358 Common - 6-phosphogluconate dehydrogenase, NAD-binding MSMEG_6341 46 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 118470412 Common - 5,10-methylenetetrahydromethanopterin reductase MSMEG_3445 35 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118467581 Common recO DNA repair protein RecO MSMEG_4491 68 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 118470840 Pathogen - hypothetical protein MSMEG_5269 1 None None None 118468588 Common - putative acyl-CoA dehydrogenase MSMEG_2130 131 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118471220 Common - hypothetical protein MSMEG_5434 1 None None None 118471207 Common - MFS permease MSMEG_5556 123 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118468717 Common - cytochrome P450 MSMEG_2240 88 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118469402 Common - hypothetical protein MSMEG_6574 16 None None None 118468970 Common - ABC-type drug export system, membrane protein MSMEG_6510 114 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 118468693 Common - hypothetical protein MSMEG_6343 51 COG0622 COG0622, Predicted phosphoesterase General function prediction only 118473615 Common - iron permease FTR1 MSMEG_5418 100 COG0672 FTR1, High-affinity Fe2+/Pb2+ permease Inorganic ion transport and metabolism 118473310 Pathogen - hypothetical protein MSMEG_6651 1 None None None 118470524 Pathogen - hypothetical protein MSMEG_5535 1 None None None 118468673 Common - hydrolase, alpha/beta fold family protein MSMEG_2036 112 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118468200 Common - IgiC, putative MSMEG_4610 42 COG3473 COG3473, Maleate cis-trans isomerase Secondary metabolites biosynthesis, transport, and catabolism 118467929 Common - ISMsm4, transposase MSMEG_1239 43 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118467425 Pathogen - hypothetical protein MSMEG_3466 1 None None None 118472348 Common - hypothetical protein MSMEG_5079 10 None None None 118469060 Common - ABC transporter MSMEG_4470 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 118468443 Common - sensor histidine kinase PhoR MSMEG_5870 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 118473082 Common - enoyl-CoA hydratase MSMEG_5886 174 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118468409 Common - ATP-dependent protease La (LON) domain subfamily protein MSMEG_0839 51 COG2802 COG2802, Uncharacterized protein, similar to the N-terminal domain of Lon protease General function prediction only 118470355 Common - hypothetical protein MSMEG_2268 92 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 118469986 Common - hypothetical protein MSMEG_5490 35 None None None 118473847 Common - amidohydrolase 2 MSMEG_0362 7 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118468236 Common ispG 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase MSMEG_2580 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 118472855 Common rarD RarD protein MSMEG_5462 16 COG2962 RarD, Predicted permeases General function prediction only 118468705 Common - steroid monooxygenase MSMEG_3011 61 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118468996 Common - transcriptional regulatory protein MSMEG_6731 37 COG1309 AcrR, Transcriptional regulator Transcription 118468794 Common - O-antigen polymerase, putative MSMEG_5960 4 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 118468665 Common - integral membrane protein MSMEG_5165 14 COG3162 COG3162, Predicted membrane protein Function unknown 118468721 Common - aldehyde dehydrogenase (NAD) family protein MSMEG_1306 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118473539 Common ribD riboflavin biosynthesis protein RibD MSMEG_3067 209 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 118467398 Pathogen - hypothetical protein MSMEG_3971 1 None None None 118470995 Common - IS1096, tnpR protein MSMEG_6149 44 None None None 118468135 Common hisC putative aminotransferase MSMEG_6351 239 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 118469440 Common - integral membrane protein MSMEG_5407 12 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 118473526 Common - CDP-diacylglycerol--serine O-phosphatidyltransferase MSMEG_0860 140 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 118467384 Common - LysR-family protein transcriptional regulator MSMEG_2797 180 COG0583 LysR, Transcriptional regulator Transcription 118468342 Pathogen - hypothetical protein MSMEG_0395 1 None None None 118470226 Common - L-carnitine dehydratase/bile acid-inducible protein F MSMEG_2171 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118467347 Common - fructokinase MSMEG_5577 153 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 118470338 Common - twin-arginine translocation pathway signal MSMEG_0872 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 118467871 Common - putative oxidoreductase MSMEG_4425 3 COG0778 NfnB, Nitroreductase Energy production and conversion 118471268 Common ehuC ectoine/hydroxyectoine ABC transporter, permease protein EhuC MSMEG_3548 174 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 118471412 Common - pyruvate decarboxylase MSMEG_5826 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 118469255 Common - short chain dehydrogenase MSMEG_0269 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470273 Common - Low molecular weight antigen MTB12 MSMEG_3903 1 None None None 118470030 Common - transmembrane transport protein MSMEG_4458 30 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 118467881 Common - Adenylate and Guanylate cyclase catalytic domain protein MSMEG_5018 28 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 118472790 Common - aldehyde-alcohol dehydrogenase MSMEG_0276 62 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118468603 Common - short-chain dehydrogenase/reductase SDR MSMEG_3367 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118469016 Common - hypothetical protein MSMEG_6723 16 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 118470731 Common - virulence factor mce family protein MSMEG_4792 25 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118471685 Common - major facilitator superfamily protein MFS_1 MSMEG_3373 65 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118472831 Common - hypothetical protein MSMEG_0751 31 COG3552 CoxE, Protein containing von Willebrand factor type A (vWA) domain General function prediction only 118470875 Common - hypothetical protein MSMEG_3062 4 COG4907 COG4907, Predicted membrane protein Function unknown 118472110 Pathogen - hypothetical protein MSMEG_3282 1 None None None 118473634 Common - MutT/nudix family protein MSMEG_6927 68 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 118473319 Common - LpqV protein MSMEG_5281 1 None None None 118469119 Common - 6-phosphogluconate dehydrogenase, NAD-binding MSMEG_4817 172 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 118470668 Common - hypothetical protein MSMEG_3080 93 COG0391 COG0391, Uncharacterized conserved protein Function unknown 118470233 Common - acetyl-CoA acetyltransferase MSMEG_6008 187 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118470903 Common - sugar ABC transporter substrate-binding protein MSMEG_6804 90 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118467985 Common - beta-lactamase MSMEG_4455 141 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 118468227 Common - hypothetical protein MSMEG_4476 1 None None None 118468634 Common hrpA ATP-dependent helicase HrpA MSMEG_6587 131 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 118472964 Pathogen - gp35 protein MSMEG_2141 1 None None None 118470022 Pathogen - hypothetical protein MSMEG_2253 1 None None None 118470798 Common - amidohydrolase family protein MSMEG_2232 32 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118467724 Common - hypothetical protein MSMEG_2133 3 COG1993 COG1993, Uncharacterized conserved protein Function unknown 118473474 Common - amino acid carrier protein MSMEG_2332 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 118469770 Common - ATP-binding protein MSMEG_6593 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 118471160 Common - hydrolase, alpha/beta fold family protein, putative MSMEG_1655 20 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118472300 Common - cobalt transport protein MSMEG_4469 31 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 118472358 Common - hypothetical protein MSMEG_1000 1 None None None 118472264 Common - 4Fe-4S ferredoxin, iron-sulfur binding protein MSMEG_1847 163 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 118469247 Common - putative hydrolase MSMEG_6906 131 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118472903 Common - universal stress protein family protein, putative MSMEG_3811 92 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 118470113 Common - acyltransferase 3 MSMEG_0206 73 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 118468326 Common - ABC transporter efflux protein, DrrB family protein MSMEG_3118 13 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 118471948 Common - carboxyvinyl-carboxyphosphonate phosphorylmutase MSMEG_4393 109 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 118471487 Common - isovaleryl-CoA dehydrogenase MSMEG_1991 166 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118468438 Common - hypothetical protein MSMEG_0082 4 None None None 118469558 Pathogen - hypothetical protein MSMEG_1261 1 None None None 118471780 Common obgE GTPase ObgE MSMEG_4623 249 COG0536 Obg, Predicted GTPase General function prediction only 118468626 Common - glyoxylate reductase MSMEG_0604 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 118472665 Common - glyoxalase family protein MSMEG_5216 24 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 118470645 Common - hypothetical protein MSMEG_5592 12 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118469014 Common - ATPase MSMEG_3596 22 COG0433 COG0433, Predicted ATPase General function prediction only 118471665 Common - 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase MSMEG_2900 132 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118468102 Common - phosphoglycerate mutase, putative MSMEG_4107 30 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 118471817 Common - hypothetical protein MSMEG_4820 97 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118472088 Common - binding protein MSMEG_5664 127 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 118471051 Common - 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase MSMEG_0935 161 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 118469736 Common - IS1096, tnpA protein MSMEG_4926 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118472153 Common - probable acyltransferase MSMEG_5041 40 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 118468358 Common rpsN ribosomal protein S14p/S29e MSMEG_1468 210 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 118469574 Common - HTH-type transcriptional regulator AlsR MSMEG_1895 190 COG0583 LysR, Transcriptional regulator Transcription 118471009 Common - ABC transporter, ATP-binding protein MSMEG_4557 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 118471230 Common glnA glutamine synthetase, catalytic domain MSMEG_3561 222 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 118473858 Common - hydrolase, alpha/beta fold family protein, putative MSMEG_2517 77 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118472913 Common - hypothetical protein MSMEG_1950 2 None None None 118469249 Common - hypothetical protein MSMEG_4558 11 None None None 118469871 Common - glutamate dehydrogenase MSMEG_5442 171 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 118468109 Common - hypothetical protein MSMEG_0897 44 COG3395 COG3395, Uncharacterized protein conserved in bacteria Function unknown 118468763 Common - hypothetical protein MSMEG_5645 3 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 118471402 Common - ABC-transporter integral membrane protein MSMEG_0133 77 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 118471959 Common - putative aminopeptidase 2 MSMEG_5828 44 COG1362 LAP4, Aspartyl aminopeptidase Amino acid transport and metabolism 118472195 Common - transcriptional regulator, TetR family protein MSMEG_3874 30 COG1309 AcrR, Transcriptional regulator Transcription 118469916 Common - probable membrane sugar transferase MSMEG_1426 137 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 118472341 Common - dienelactone hydrolase family protein MSMEG_2444 101 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 118471935 Common - PntAB protein MSMEG_0151 117 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 118471322 Common glnT glutamine synthetase, type III MSMEG_6260 223 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 118473225 Common - hypothetical protein MSMEG_5498 1 None None None 118468379 Common - hypothetical protein MSMEG_0256 8 None None None 118472221 Common - methyltransferase MSMEG_5980 44 None None None 118467964 Common - carbon-monoxide dehydrogenase, large subunit MSMEG_0746 113 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 118467989 Common - pyruvate dehydrogenase E1 component, alpha subunit MSMEG_4712 155 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 118471843 Common - zinc-containing alcohol dehydrogenase superfamily protein MSMEG_4027 177 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118471766 Common - hypothetical protein MSMEG_4943 1 None None None 118471115 Common - short chain alcohol dehydrogenase MSMEG_5053 238 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118468036 Common - acyltransferase MSMEG_2356 96 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 118469171 Common infC translation initiation factor IF-3 MSMEG_3793 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 118473825 Common - integral membrane protein MSMEG_5604 14 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 118468370 Common - hypothetical protein MSMEG_2997 76 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 118470154 Common - hypothetical protein MSMEG_5928 16 COG1285 SapB, Uncharacterized membrane protein Function unknown 118471280 Common - iron-sulfur binding oxidoreductase MSMEG_0637 49 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 118473113 Common - hypothetical protein MSMEG_2665 11 None None None 118467715 Common ruvA Holliday junction DNA helicase motor protein MSMEG_2944 209 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 118468748 Common - putative esterase MSMEG_3463 50 COG3509 LpqC, Poly(3-hydroxybutyrate) depolymerase Secondary metabolites biosynthesis, transport, and catabolism 118468011 Common - [NAD+] benzaldehyde dehydrogenase MSMEG_4165 221 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118468056 Common - hypothetical cytosolic protein MSMEG_1282 21 COG4924 COG4924, Uncharacterized protein conserved in bacteria Function unknown 118469808 Common - oxidoreductase, FAD/FMN-binding MSMEG_3338 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 118473487 Pathogen - hypothetical protein MSMEG_3965 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 118468321 Common - N5,N10- methylenetetrahydromethanopterin reductase-related protein MSMEG_1996 83 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118473781 Common - transcriptional regulator, GntR family protein MSMEG_0480 127 COG1802 GntR, Transcriptional regulators Transcription 118468291 Common - 2-hydroxy-3-oxopropionate reductase MSMEG_5477 194 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 118467837 Common - serine/threonine-protein kinase PknD MSMEG_1200 195 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 118469726 Common - gp61 protein MSMEG_3289 126 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118471966 Common - transcriptional regulatory protein MSMEG_2179 14 COG1309 AcrR, Transcriptional regulator Transcription 118472303 Common - hypothetical protein MSMEG_1779 2 None None None 118468909 Common - sulfate/thiosulfate import ATP-binding protein CysA 2 MSMEG_6521 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 118472870 Common - oxidoreductase MSMEG_6602 57 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118468969 Common - cytochrome p450 MSMEG_2289 92 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118468902 Common - PPE family protein, putative MSMEG_5350 1 None None None 118468792 Common - alpha-galactosidase MSMEG_0514 54 COG1486 CelF, Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases Carbohydrate transport and metabolism 118471134 Common - peptide transport system ATP-binding protein MSMEG_6120 249 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 118468636 Common - glycerol-3-phosphate dehydrogenase 2 MSMEG_1736 149 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 118469654 Common - 3-hydroxybutyryl-CoA dehydrogenase MSMEG_4115 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 118467411 Common - O-demethylpuromycin-O-methyltransferase MSMEG_0367 45 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 118470567 Common gyrB DNA gyrase subunit B MSMEG_0005 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 118474013 Common - hypothetical protein MSMEG_3766 1 None None None 118473001 Common nadB L-aspartate oxidase MSMEG_3200 226 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 118473258 Common - hypothetical protein MSMEG_6100 4 None None None 118468678 Common - hypothetical protein MSMEG_6450 1 None None None 118473496 Common - integral membrane protein MSMEG_1942 64 COG1814 COG1814, Uncharacterized membrane protein Function unknown 118473262 Common - ISMsm2, transposase MSMEG_3510 52 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 118471211 Pathogen - hypothetical protein MSMEG_1223 1 None None None 118470143 Pathogen - hypothetical protein MSMEG_4642 1 None None None 118469851 Common - 3-hydroxyacyl-CoA dehydrogenase type-2 MSMEG_4871 229 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471019 Common purB adenylosuccinate lyase MSMEG_5847 186 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 118471618 Common - 2-Nitropropane dioxygenase MSMEG_5182 98 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 118467345 Common - Rieske [2Fe-2S] domain protein MSMEG_4840 80 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 118467562 Common - transcriptional regulator LysR family protein MSMEG_4609 183 COG0583 LysR, Transcriptional regulator Transcription 118472574 Common - deoxyribodipyrimidine photo-lyase MSMEG_2576 142 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 118472112 Common - hypothetical protein MSMEG_6119 23 None None None 118467835 Common atpE F0F1 ATP synthase subunit C MSMEG_4941 2 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 118471928 Common - malonyl CoA-acyl carrier protein transacylase MSMEG_4325 203 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 118470951 Common - DEAD/DEAH box helicase MSMEG_3885 117 COG4581 COG4581, Superfamily II RNA helicase DNA replication, recombination, and repair 118468950 Common - probable ribbon-helix-helix transcription factor, family protein MSMEG_1283 6 COG4423 COG4423, Uncharacterized protein conserved in bacteria Function unknown 118469332 Common - peptidyl-prolyl cis-trans isomerase MSMEG_2973 71 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 118468082 Common murG N-acetylglucosaminyl transferase MSMEG_4227 207 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 118468860 Common - two-component system sensor kinase MSMEG_4968 143 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 118468818 Common glyA serine hydroxymethyltransferase MSMEG_5249 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 118468295 Pathogen - hypothetical protein MSMEG_3728 1 None None None 118473178 Common hisS histidyl-tRNA synthetase MSMEG_2976 247 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 118470755 Common - putative ECF sigma factor RpoE1 MSMEG_1690 139 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118471082 Common pntB NAD(P) transhydrogenase, beta subunit MSMEG_0109 123 COG1282 PntB, NAD/NADP transhydrogenase beta subunit Energy production and conversion 118470884 Common - putative transcriptional regulator MSMEG_5032 127 COG1733 COG1733, Predicted transcriptional regulators Transcription 118473863 Common - cyclohexanecarboxylate-CoA ligase MSMEG_4112 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118473988 Common - salicylate hydroxylase MSMEG_4641 66 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118471033 Pathogen - hypothetical protein MSMEG_3439 1 None None None 118471386 Common - choloylglycine hydrolase, putative MSMEG_5454 48 COG3049 COG3049, Penicillin V acylase and related amidases Cell envelope biogenesis, outer membrane 118467456 Common - transcriptional regulator, MerR family protein MSMEG_4397 83 COG0789 SoxR, Predicted transcriptional regulators Transcription 118468157 Common uppS undecaprenyl diphosphate synthase MSMEG_5256 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 118470501 Common - integral membrane protein MSMEG_1761 9 None None None 118468936 Common - glycosidase MSMEG_1209 31 COG2152 COG2152, Predicted glycosylase Carbohydrate transport and metabolism 118470772 Common - 3-hydroxyisobutyrate dehydrogenase family protein MSMEG_2170 182 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 118467830 Common - oxidoreductase, zinc-binding dehydrogenase family protein MSMEG_0127 181 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 118472887 Common - mycothione/glutathione reductase MSMEG_2611 244 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 118473755 Common - hypothetical protein MSMEG_0907 2 None None None 118471327 Common - transcriptional regulator, PadR family protein MSMEG_6903 17 COG1695 COG1695, Predicted transcriptional regulators Transcription 118468962 Common - fatty acid hydroxylase MSMEG_3529 7 None None None 118468129 Common rpoB DNA-directed RNA polymerase subunit beta MSMEG_1367 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 118471792 Common - transcriptional regulator, GntR family protein MSMEG_5630 119 COG2188 PhnF, Transcriptional regulators Transcription 118473524 Common - CAIB/BAIF family protein MSMEG_6689 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118469901 Common - hypothetical protein MSMEG_1111 13 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 118471379 Common - hypothetical protein MSMEG_3799 3 None None None 118472596 Common lpdA dihydrolipoamide dehydrogenase MSMEG_0903 241 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 118470448 Common - prephenate dehydratase MSMEG_6418 206 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 118474022 Pathogen - hypothetical protein MSMEG_3293 1 None None None 118470694 Common - peptide synthetase mbtf MSMEG_4510 204 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118467937 Common - AraC-family protein transcriptional regulator MSMEG_2590 92 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 118469545 Common - transcriptional regulator, CadC MSMEG_3856 166 COG3710 CadC, DNA-binding winged-HTH domains Transcription 118471189 Common - transcriptional repressor, TetR family protein, putative MSMEG_4142 61 COG1309 AcrR, Transcriptional regulator Transcription 118473199 Common - acetaldehyde dehydrogenase MSMEG_4149 38 COG4569 MhpF, Acetaldehyde dehydrogenase (acetylating) Secondary metabolites biosynthesis, transport, and catabolism 118473041 Common - oxidoreductase MSMEG_5596 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470350 Common - ABC transporter, ATP-binding protein MSMEG_1366 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 118473795 Common - acetyl-CoA acetyltransferase MSMEG_5608 120 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118468475 Common map methionine aminopeptidase, type I MSMEG_5683 242 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 118469123 Common - hypothetical protein MSMEG_2107 7 COG3456 COG3456, Uncharacterized conserved protein, contains FHA domain Signal transduction mechanisms 118471739 Common - oxygenase MSMEG_0849 13 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118469166 Common - Rieske [2Fe-2S] domain, putative MSMEG_4809 48 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 118468272 Common ligD DNA polymerase LigD, polymerase domain MSMEG_6301 66 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 118473512 Common - hypothetical protein MSMEG_2624 101 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 118468007 Common metK S-adenosylmethionine synthetase MSMEG_3055 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 118473181 Common - ribose transport ATP-binding protein RbsA MSMEG_3091 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 118471523 Common - DNA-binding response regulator, PhoP family protein MSMEG_2916 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 118471093 Common - serine esterase, cutinase family protein MSMEG_1529 3 COG0400 COG0400, Predicted esterase General function prediction only 118471338 Common - short chain dehydrogenase MSMEG_5711 230 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118468337 Common - probable conserved membrane protein MSMEG_0235 1 None None None 118469709 Common - carbohydrate kinase MSMEG_0504 85 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 118467528 Common - putative cyanamide hydratase MSMEG_5764 22 COG1713 COG1713, Predicted HD superfamily hydrolase involved in NAD metabolism Coenzyme metabolism 118472997 Common - transcriptional regulator, TetR family protein MSMEG_0916 17 COG1309 AcrR, Transcriptional regulator Transcription 118472865 Common - probable transcriptional regulatory protein MSMEG_2309 39 COG1309 AcrR, Transcriptional regulator Transcription 118470065 Common - transcriptional regulator, GntR family protein MSMEG_6881 126 COG1802 GntR, Transcriptional regulators Transcription 118473692 Common - integral membrane protein MSMEG_3276 64 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 118472706 Common - permease of the major facilitator superfamily protein MSMEG_2137 172 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118468465 Common - heparin-binding hemagglutinin MSMEG_0919 5 None None None 118468416 Common - hypothetical protein MSMEG_4306 24 COG1579 COG1579, Zn-ribbon protein, possibly nucleic acid-binding General function prediction only 118469070 Common - hypothetical protein MSMEG_4453 1 None None None 118467647 Common - PE family protein MSMEG_0063 1 None None None 118468597 Pathogen - hypothetical protein MSMEG_4594 1 None None None 118467579 Common - amino acid carrier protein MSMEG_1052 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 118469240 Common - LpqM protein MSMEG_4913 32 COG2321 COG2321, Predicted metalloprotease General function prediction only 118473374 Common - hypothetical protein MSMEG_4003 4 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 118469317 Common - hypothetical protein MSMEG_5314 8 COG2852 COG2852, Uncharacterized protein conserved in bacteria Function unknown 118472151 Common recA protein RecA MSMEG_2723 218 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 118471855 Common - transcriptional regulatory protein MSMEG_6829 96 COG1733 COG1733, Predicted transcriptional regulators Transcription 118473619 Common - Citrate transporter MSMEG_0851 159 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 118471734 Common - pyridoxamine 5'-phosphate oxidase family protein MSMEG_0048 18 COG3871 COG3871, Uncharacterized stress protein (general stress protein 26) General function prediction only 118469343 Common - oxidoreductase MSMEG_3409 195 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118473292 Common - peptidase S9, prolyl oligopeptidase MSMEG_4633 105 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 118471010 Common - cupin domain protein MSMEG_3394 8 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 118471838 Common - hypothetical protein MSMEG_3568 1 COG2906 Bfd, Bacterioferritin-associated ferredoxin Inorganic ion transport and metabolism 118472949 Common - antar domain protein MSMEG_6741 11 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 118471460 Common - hypothetical protein MSMEG_4318 51 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 118469602 Common - 3-hydroxybutyryl-CoA dehydrogenase MSMEG_0912 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 118471425 Common - probable regulatory protein MSMEG_4779 25 COG3226 COG3226, Uncharacterized protein conserved in bacteria Function unknown 118467968 Common - adenylate and Guanylate cyclase catalytic domain protein MSMEG_4279 64 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 118470633 Common - epoxide hydrolase MSMEG_6708 123 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118470124 Common - 5-exo-alcohol dehydrogenase MSMEG_6296 209 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 118468197 Common - acyl-CoA dehydrogenase MSMEG_4166 160 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472614 Common - hypothetical protein MSMEG_4461 8 COG5522 COG5522, Predicted integral membrane protein Function unknown 118470867 Common - transcriptional regulator, GntR family protein MSMEG_2910 116 COG1802 GntR, Transcriptional regulators Transcription 118473883 Common - acyl-CoA dehydrogenase MSMEG_4593 21 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118471413 Common - cytochrome p450 MSMEG_6030 83 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118469490 Common - pe family protein MSMEG_0620 1 None None None 118473644 Common mdcB triphosphoribosyl-dephospho-CoA synthase MdcB MSMEG_6634 41 COG1767 CitG, Triphosphoribosyl-dephospho-CoA synthetase Coenzyme metabolism 118468150 Common - hypothetical protein MSMEG_0369 8 None None None 118471624 Common - Periplasmic binding protein MSMEG_1039 23 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 118470929 Common - aldehyde dehydrogenase MSMEG_2163 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118468804 Common - DNA or RNA helicase of superfamily protein II MSMEG_0866 55 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 118472736 Common - hypothetical protein MSMEG_0873 1 None None None 118473709 Common - antigen 85-C MSMEG_2078 14 COG0627 COG0627, Predicted esterase General function prediction only 118472284 Common - decarboxylase MSMEG_2495 40 COG3473 COG3473, Maleate cis-trans isomerase Secondary metabolites biosynthesis, transport, and catabolism 118468958 Pathogen - hypothetical protein MSMEG_4498 1 None None None 118469883 Common - respiratory-chain NADH dehydrogenase domain, 51 kda subunit MSMEG_4812 172 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 118471596 Common lysS lysyl-tRNA synthetase MSMEG_6094 245 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 118473912 Common - ISMsm7, transposase orfB MSMEG_1249 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 118472039 Common - MK35 lipoprotein MSMEG_5456 1 None None None 118473066 Common - glyoxalase/bleomycin resistance protein/dioxygenase MSMEG_4313 9 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 118469627 Common - organophopsphate acid anhydrase MSMEG_4392 71 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 118473430 Common - dehydrogenase MSMEG_5443 150 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 118473078 Common - hydrolase, alpha/beta hydrolase fold family protein MSMEG_4477 80 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118473590 Common - putative formamidopyrimidine-DNA glycosylase MSMEG_4683 178 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 118467674 Common - flavodoxin/nitric oxide synthase MSMEG_4178 45 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 118471579 Common surE acid phosphatase SurE MSMEG_6820 172 COG0496 SurE, Predicted acid phosphatase General function prediction only 118469117 Common eat ethanolamine permease MSMEG_1552 167 COG0833 LysP, Amino acid transporters Amino acid transport and metabolism 118469713 Common - ion channel membrane protein MSMEG_1945 80 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 118468190 Common - hypothetical protein MSMEG_6811 15 None None None 118470173 Common - drug resistance transporter Bcr/CflA subfamily protein MSMEG_5047 152 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118467745 Common - short-chain dehydrogenase/reductase SDR MSMEG_6592 206 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118469953 Common - glycosyl transferase, putative MSMEG_5981 11 COG5017 COG5017, Uncharacterized conserved protein Function unknown 118467752 Pathogen - hypothetical protein MSMEG_1752 1 None None None 118470942 Pathogen - hypothetical protein MSMEG_1868 1 None None None 118468885 Common - copper-translocating P-type ATPase MSMEG_5014 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 118473640 Common - glutamine synthetase MSMEG_3827 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 118473317 Common - metallopeptidase MSMEG_6138 142 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 118472131 Common - hypothetical protein MSMEG_6329 13 COG3554 COG3554, Uncharacterized protein conserved in bacteria Function unknown 118469153 Common - putative ammonia monooxygenase superfamily protein MSMEG_1698 19 COG3180 AbrB, Putative ammonia monooxygenase General function prediction only 118471828 Pathogen - hypothetical protein MSMEG_1584 1 None None None 118471938 Common - hypothetical protein MSMEG_4141 11 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118468364 Common - short chain dehydrogenase MSMEG_2212 69 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118471029 Common - cystathionine gamma-lyase MSMEG_2394 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 118472066 Common - hypothetical protein MSMEG_1598 3 None None None 118472861 Common - amidase MSMEG_2521 208 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 118471457 Common phoP DNA-binding response regulator PhoP MSMEG_5872 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 118473388 Common - glucose-methanol-choline oxidoreductase MSMEG_5944 68 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 118470375 Common - Pks14 protein MSMEG_4900 19 None None None 118469326 Common - hypothetical protein MSMEG_2928 7 None None None 118470750 Common - calpastatin MSMEG_3577 28 COG5579 COG5579, Uncharacterized conserved protein Function unknown 118467999 Common - cytochrome P450 monooxygenase MSMEG_1213 92 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118473053 Common hemD uroporphyrinogen-III synthase MSMEG_0954 183 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 118471129 Common - hypothetical protein MSMEG_1748 56 COG3542 COG3542, Uncharacterized conserved protein Function unknown 118469177 Common - ABC-type transport system periplasmic substrate-binding protein MSMEG_1216 117 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 118472091 Common - hypothetical protein MSMEG_0360 3 None None None 118472186 Common - hypothetical protein MSMEG_3016 78 COG4196 COG4196, Uncharacterized protein conserved in bacteria Function unknown 118469684 Common - ribose transport system permease protein RbsC MSMEG_4001 111 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 118468929 Common xylB xylulokinase MSMEG_3257 165 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 118472378 Common - Periplasmic binding protein MSMEG_2319 23 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 118467636 Common - two-component system sensor kinase MSMEG_3448 120 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 118469315 Common - creatinine amidohydrolase MSMEG_6870 87 COG1402 COG1402, Uncharacterized protein, putative amidase General function prediction only 118469667 Common - hypothetical protein MSMEG_0563 3 None None None 118471407 Common - two-component system sensor kinase MSMEG_0458 118 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 118473185 Common - putative conserved exported protein MSMEG_0635 24 COG3786 COG3786, Uncharacterized protein conserved in bacteria Function unknown 118471805 Common - enoyl-CoA hydratase MSMEG_2328 182 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118473308 Pathogen - hypothetical protein MSMEG_6611 1 None None None 118470804 Common - putative monovalent cation/H+ antiporter subunit C MSMEG_0847 17 COG1006 MnhC, Multisubunit Na+/H+ antiporter, MnhC subunit Inorganic ion transport and metabolism 118470533 Common - glucose 1-dehydrogenase, putative MSMEG_0655 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118468839 Pathogen - hypothetical protein MSMEG_0173 1 None None None 118471300 Common - binding-protein-dependent transport systems inner membrane component MSMEG_0641 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118472898 Common hisIE phosphoribosyl-AMP pyrophosphatase/phosphoribosyl-ATP cyclohydrolase MSMEG_3212 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 118470076 Common - acyl-CoA synthetase MSMEG_0304 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118471447 Common - transporter, major facilitator family protein, putative MSMEG_0449 49 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 118469991 Common - probable transcriptional regulatory protein, putative MSMEG_3177 48 COG1309 AcrR, Transcriptional regulator Transcription 118470747 Common - hypothetical protein MSMEG_1276 6 COG4997 COG4997, Uncharacterized conserved protein Function unknown 118472542 Common - hydroxylase MSMEG_3511 22 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118473765 Common - monooxygenase, flavin-binding family protein MSMEG_6440 73 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118468727 Common - cytochrome P450 MSMEG_1167 76 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118469078 Common - major facilitator family protein transporter MSMEG_2966 146 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118467432 Common - isocitrate dehydrogenase, NADP-dependent MSMEG_1654 65 COG2838 Icd, Monomeric isocitrate dehydrogenase Energy production and conversion 118467894 Common - hypothetical protein MSMEG_5793 1 None None None 118472797 Common - monooxygenase MSMEG_2310 83 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118471060 Common - hypothetical protein MSMEG_3824 17 None None None 118472149 Common gatB aspartyl/glutamyl-tRNA amidotransferase subunit B MSMEG_2367 212 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 118470917 Common - 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase MSMEG_2566 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118469114 Common - subtilase family protein MSMEG_0624 103 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 118468910 Common - alcohol dehydrogenase, zinc-containing MSMEG_2317 196 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 118472030 Common - transmembrane efflux pump MSMEG_4427 181 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118469205 Common - putative transposase MSMEG_4158 1 None None None 118467757 Common - putative methyltransferase MSMEG_4708 7 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 118471157 Common - monooxygenase MSMEG_3039 60 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118469660 Common - branched-chain amino acid transport system ATP-binding protein MSMEG_6877 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 118471163 Common - peroxidase MSMEG_6324 12 None None None 118473423 Common - hypothetical protein MSMEG_3229 1 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 118467530 Common - nonspecific lipid-transfer protein MSMEG_6561 79 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118469728 Common - hypothetical protein MSMEG_0016 32 COG3251 COG3251, Uncharacterized protein conserved in bacteria Function unknown 118469305 Pathogen - hypothetical protein MSMEG_1722 1 None None None 118471975 Common - hypothetical protein MSMEG_1538 2 COG4842 COG4842, Uncharacterized protein conserved in bacteria Function unknown 118469982 Common - putative inner membrane protein MSMEG_0174 6 COG2149 COG2149, Predicted membrane protein Function unknown 118470928 Common - hypothetical protein MSMEG_0693 1 None None None 118472769 Common ureA urease subunit gamma MSMEG_3627 96 COG0831 UreA, Urea amidohydrolase (urease) gamma subunit Amino acid transport and metabolism 118470193 Common thiD phosphomethylpyrimidine kinase MSMEG_0825 217 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 118468547 Common - transketolase, central region MSMEG_2467 171 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 118470811 Common - thioesterase family protein MSMEG_0760 9 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 118473494 Common - hydrolase, alpha/beta fold family protein MSMEG_2786 27 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118469409 Common - hypothetical protein MSMEG_6936 11 None None None 118469676 Common - cyclohexanone monooxygenase MSMEG_2884 67 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118472920 Common - cupin domain protein MSMEG_5707 14 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 118467497 Common nth endonuclease III MSMEG_6187 238 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 118472761 Common - bacterial alkaline phosphatase MSMEG_1012 84 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 118472383 Common - extracellular solute-binding protein, family protein 3 MSMEG_1612 142 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 118471519 Common - Ku protein MSMEG_5580 63 COG1273 COG1273, Uncharacterized conserved protein Function unknown 118469394 Common - 5-dehydro-4-deoxyglucarate dehydratase MSMEG_6133 209 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 118469836 Common mmsA methylmalonate-semialdehyde dehydrogenase MSMEG_2449 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118471276 Common - aldo/keto reductase MSMEG_5192 199 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 118469775 Common - glutaredoxin MSMEG_1017 37 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 118467774 Common metE 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MSMEG_6638 142 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 118468254 Common - helix-turn-helix, Fis-type MSMEG_6814 16 COG1846 MarR, Transcriptional regulators Transcription 118472502 Pathogen - hypothetical protein MSMEG_3893 2 COG2339 COG2339, Predicted membrane protein Function unknown 118470828 Common - transcriptional regulator, ArsR family protein MSMEG_5603 29 COG0640 ArsR, Predicted transcriptional regulators Transcription 118468822 Common hemA glutamyl-tRNA reductase MSMEG_0952 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 118472259 Common - hypothetical protein MSMEG_3417 6 None None None 118470982 Common - hypothetical glycosyl transferase MSMEG_0389 36 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 118472327 Common - IclR-family protein transcriptional regulator MSMEG_6118 119 COG1414 IclR, Transcriptional regulator Transcription 118469388 Common - putative sialic acid transporter MSMEG_0875 204 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118473293 Common - gp55 protein MSMEG_3163 1 None None None 118468774 Common - hypothetical protein MSMEG_4729 3 None None None 118472190 Common - acetolactate synthase MSMEG_4460 222 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 118471633 Common - oxidoreductase MSMEG_4422 236 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 118469596 Common ssuD nitrilotriacetate monooxygenase component A MSMEG_4590 67 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118467794 Common - hypothetical protein MSMEG_6381 9 None None None 118471888 Common - CalR5 protein MSMEG_4463 30 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 118467548 Common - transcriptional regulator MSMEG_2547 59 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 118473796 Common - acyl-CoA synthetase MSMEG_0599 222 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118472025 Common - glycosyl transferase MSMEG_5948 72 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 118472910 Common - Asp/Glu racemase MSMEG_1319 29 COG3473 COG3473, Maleate cis-trans isomerase Secondary metabolites biosynthesis, transport, and catabolism 118471105 Common - aldehyde dehydrogenase (NAD) family protein MSMEG_2552 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118472076 Common - phosphoglycerate mutase family protein MSMEG_6545 62 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 118470269 Common - branched-chain amino acid ABC transporter, permease protein MSMEG_3249 153 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 118473893 Common - GntR-family protein transcriptional regulator MSMEG_2173 115 COG2186 FadR, Transcriptional regulators Transcription 118470399 Common selA selenocysteine synthase MSMEG_1850 64 COG1921 SelA, Selenocysteine synthase [seryl-tRNASer selenium transferase] Amino acid transport and metabolism 118470187 Common - hypothetical protein MSMEG_5157 1 None None None 118471810 Common - secreted protein MSMEG_1837 23 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118470494 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding MSMEG_3422 226 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 118471555 Common - transcriptional regulator MSMEG_1117 29 COG2186 FadR, Transcriptional regulators Transcription 118467613 Common nadA quinolinate synthetase MSMEG_3199 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 118470722 Common - hypothetical protein MSMEG_3079 140 COG1660 COG1660, Predicted P-loop-containing kinase General function prediction only 118469622 Common - transcriptional regulator, TetR family protein MSMEG_5850 7 COG3226 COG3226, Uncharacterized protein conserved in bacteria Function unknown 118470310 Common - putative monooxygenase MSMEG_4083 72 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118472528 Common - CAIB/BAIF family protein MSMEG_4120 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118470317 Common - hypothetical protein MSMEG_6006 1 None None None 118468982 Common - putative transcriptional regulator MSMEG_5025 26 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 118470785 Common - catalase MSMEG_4204 20 None None None 118470818 Common - hypothetical protein MSMEG_6456 1 None None None 118468421 Common - feruloyl-CoA synthetase MSMEG_4065 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118469931 Common cysT sulfate ABC transporter, permease protein CysT MSMEG_4532 211 COG0555 CysU, ABC-type sulfate transport system, permease component Posttranslational modification, protein turnover, chaperones 118472784 Common - hypothetical protein MSMEG_2861 1 None None None 118472622 Common - short chain dehydrogenase MSMEG_2598 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118472081 Common - bacterial regulatory protein, GntR family protein MSMEG_0596 125 COG2186 FadR, Transcriptional regulators Transcription 118473011 Common - enoyl-CoA hydratase MSMEG_5185 109 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118469193 Common - transcriptional regulator, IclR family protein MSMEG_3396 25 COG1414 IclR, Transcriptional regulator Transcription 118470277 Common - hypothetical protein MSMEG_5921 17 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 118472846 Common - acyl-CoA synthetase MSMEG_3687 212 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118470434 Common - hypothetical protein MSMEG_3130 1 None None None 118468221 Common - acyltransferase, ws/dgat/mgat subfamily protein MSMEG_0290 28 None None None 118472771 Common - ABC-type transporter, permease components MSMEG_4702 25 COG3336 COG3336, Predicted membrane protein Function unknown 118472540 Common - UbiE/COQ5 methyltransferase MSMEG_1893 36 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118469673 Common - ATP-dependent DNA helicase MSMEG_1952 231 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 118470029 Common - UvrD/Rep helicase MSMEG_1255 46 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 118468275 Common mscL large-conductance mechanosensitive channel MSMEG_5482 142 COG1970 MscL, Large-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 118472405 Common - MmpL5 protein MSMEG_1382 75 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118471288 Common - hypothetical protein MSMEG_3157 54 COG0398 COG0398, Uncharacterized conserved protein Function unknown 118468922 Common - hypothetical protein MSMEG_3826 2 None None None 118473779 Common - putative transcriptional regulator MSMEG_2039 11 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 118473732 Common - hypothetical protein MSMEG_4398 32 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118472243 Common - hypothetical protein MSMEG_0942 9 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 118470754 Pathogen - hypothetical protein MSMEG_3892 1 None None None 118469561 Common - alkanesulfonate monooxygenase MSMEG_4103 66 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118472487 Common - endoribonuclease L-PSP MSMEG_4424 57 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 118471541 Common - Rieske [2Fe-2S] domain protein MSMEG_2244 71 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 118470394 Common - patatin MSMEG_5284 119 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 118470686 Common - 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_1689 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118472460 Pathogen - hypothetical protein MSMEG_3352 1 None None None 118470300 Common - gp41 protein MSMEG_5754 66 COG0582 XerC, Integrase DNA replication, recombination, and repair 118473444 Common - glutamine ABC transporter, permease/substrate-binding protein MSMEG_5318 189 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 118472056 Common - transcriptional regulator, LuxR family protein MSMEG_1197 8 COG2771 CsgD, DNA-binding HTH domain-containing proteins Transcription 118471655 Common rnhB ribonuclease HII MSMEG_2442 212 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 118468233 Common - DNA-binding protein MSMEG_3132 42 COG1396 HipB, Predicted transcriptional regulators Transcription 118472461 Common - glycerol operon regulatory protein MSMEG_6757 113 COG1414 IclR, Transcriptional regulator Transcription 118470424 Common - acyltransferase family protein MSMEG_4704 188 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 118473381 Common - ATP-binding protein MSMEG_1934 16 None None None 118472636 Common - 1-phosphofructokinase MSMEG_0086 83 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 118468830 Pathogen - transport-associated, putative MSMEG_6544 1 None None None 118468513 Common prrA DNA-binding response regulator PrrA MSMEG_5662 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 118472334 Common - major facilitator family protein transporter MSMEG_4886 137 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118474055 Common - cupin 2 protein MSMEG_4145 17 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 118468532 Common - citrate-proton symporter MSMEG_1152 167 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118470382 Common - AP endonuclease, family protein 2 MSMEG_0941 22 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 118468785 Common - virulence factor mce family protein MSMEG_4787 30 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118469978 Common - hypothetical protein MSMEG_4857 5 COG1141 Fer, Ferredoxin Energy production and conversion 118471069 Common - major facilitator superfamily protein MSMEG_4087 127 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 118473561 Common ggt gamma-glutamyltransferase MSMEG_3076 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 118471779 Common - DNA-binding protein MSMEG_4574 110 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 118472675 Common - DNA-binding protein MSMEG_4648 28 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118467502 Common - acyl-CoA dehydrogenase family protein MSMEG_2191 152 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118467768 Common - GntR-family protein transcriptional regulator MSMEG_0454 46 COG2186 FadR, Transcriptional regulators Transcription 118468260 Common - short-chain dehydrogenase/reductase SDR MSMEG_4055 229 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118468559 Common - putative CrcB protein MSMEG_2135 1 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 118470777 Common - hypothetical protein MSMEG_6449 1 None None None 118470449 Common - AMP-dependent synthetase and ligase MSMEG_5650 221 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 118471080 Common - putative response regulator MSMEG_1082 113 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118470168 Common - glycosyl hydrolases family protein 16 MSMEG_5345 28 COG2273 SKN1, Beta-glucanase/Beta-glucan synthetase Carbohydrate transport and metabolism 118468768 Common - hypothetical protein MSMEG_1389 6 COG3327 PaaX, Phenylacetic acid-responsive transcriptional repressor Transcription 118469102 Common - 1,3-propanediol dehydrogenase MSMEG_6239 174 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 118472172 Common - linalool 8-monooxygenase MSMEG_3524 68 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118472587 Common - glutamine amidotransferase subunit PdxT MSMEG_2939 90 COG0311 PDX2, Predicted glutamine amidotransferase involved in pyridoxine biosynthesis Coenzyme metabolism 118470932 Common - Dyp-type peroxidase MSMEG_5829 52 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 118469339 Pathogen - hypothetical protein MSMEG_5820 1 None None None 118470192 Common - probable arabinosyltransferase A MSMEG_6387 5 None None None 118469234 Common ureB urease, beta subunit MSMEG_3626 96 COG0832 UreB, Urea amidohydrolase (urease) beta subunit Amino acid transport and metabolism 118468743 Common - permease for cytosine/purines, uracil, thiamine, allantoin transporter MSMEG_5730 54 COG1953 FUI1, Cytosine/uracil/thiamine/allantoin permeases Nucleotide transport and metabolism / Coenzyme metabolism 118473661 Common - hypothetical protein MSMEG_3669 3 None None None 118467490 Common fni isopentenyl-diphosphate delta-isomerase, type 2 MSMEG_2337 80 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 118470936 Common - bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein MSMEG_3072 232 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 118472538 Common - inositol-5-monophosphate dehydrogenase MSMEG_3634 233 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 118469106 Common - esterase/lipase/thioesterase MSMEG_5220 124 COG0657 Aes, Esterase/lipase Lipid metabolism 118470387 Common - hypothetical protein MSMEG_6210 6 None None None 118468419 Common - peptidase, S9A/B/C families MSMEG_0302 60 COG0657 Aes, Esterase/lipase Lipid metabolism 118471146 Common - transcriptional regulator, LysR family protein MSMEG_2544 122 COG0583 LysR, Transcriptional regulator Transcription 118467705 Common - peptidase M52, hydrogen uptake protein MSMEG_2713 34 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 118468544 Common katA catalase KatA MSMEG_6232 125 COG0753 KatE, Catalase Inorganic ion transport and metabolism 118473218 Common - hypothetical protein MSMEG_6533 9 COG2267 PldB, Lysophospholipase Lipid metabolism 118471761 Common katG catalase/peroxidase HPI MSMEG_6384 98 COG0376 KatG, Catalase (peroxidase I) Inorganic ion transport and metabolism 118468555 Common - putative transcriptional regulator MSMEG_6556 3 COG1309 AcrR, Transcriptional regulator Transcription 118471648 Common - B12 binding domain protein MSMEG_6542 15 COG5012 COG5012, Predicted cobalamin binding protein General function prediction only 118470415 Common ribH riboflavin synthase subunit beta MSMEG_3073 215 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 118470542 Common - hypothetical protein MSMEG_6932 1 None None None 118473963 Common - aminoglycoside phosphotransferase MSMEG_1006 59 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 118473165 Common - ErfK/YbiS/YcfS/YnhG family protein MSMEG_3528 28 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 118468562 Common - virulence factor Mce family protein MSMEG_6540 6 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118468536 Common - probable conserved integral membrane protein MSMEG_5077 23 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 118468023 Pathogen - hypothetical protein MSMEG_1759 1 None None None 118468125 Common ureG urease accessory protein UreG MSMEG_3623 137 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 118468560 Common - major membrane protein I MSMEG_4537 25 None None None 118468939 Common lysS lysyl-tRNA synthetase MSMEG_3796 249 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 118472762 Common - phosphoribosyltransferase MSMEG_4215 66 COG1926 COG1926, Predicted phosphoribosyltransferases General function prediction only 118470372 Common - acyl-CoA synthetase MSMEG_0131 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118469475 Common - 6-phosphofructokinase isozyme 2 MSMEG_3947 96 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 118471778 Common - hypothetical protein MSMEG_1938 5 None None None 118472582 Common - 2Fe-2S iron-sulfur cluster binding domain protein MSMEG_1885 120 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 118471438 Common - ubiquinol-cytochrome c reductase cytochrome b subunit MSMEG_4263 147 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 118472248 Pathogen - hypothetical protein MSMEG_3800 1 None None None 118469707 Common - ABC transporter, permease/ATP-binding protein MSMEG_3655 249 COG4178 COG4178, ABC-type uncharacterized transport system, permease and ATPase components General function prediction only 118470721 Common - hypothetical protein MSMEG_5635 8 None None None 118471917 Common - propionyl-CoA carboxylase beta chain MSMEG_1813 212 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 118468028 Common - hypothetical protein MSMEG_6832 6 None None None 118472166 Common - two component transcriptional regulatory protein devr MSMEG_5244 213 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118468497 Common mraW S-adenosyl-methyltransferase MraW MSMEG_4235 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 118473696 Common - 3-isopropylmalate dehydratase small subunit MSMEG_6853 69 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 118469229 Common - hypothetical protein MSMEG_0055 1 None None None 118473198 Common - hypothetical protein MSMEG_6573 6 None None None 118469100 Common - transcriptional regulator MSMEG_1542 65 COG3284 AcoR, Transcriptional activator of acetoin/glycerol metabolism Secondary metabolites biosynthesis, transport, and catabolism / Transcription 118473798 Common - methyltransferase type 11 MSMEG_1650 143 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118468585 Common - AMP-dependent synthetase and ligase MSMEG_4774 225 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118470790 Common - hemerythrin HHE cation binding region MSMEG_2415 22 None None None 118469671 Common - putative long-chain fatty-acid--CoA ligase MSMEG_5739 196 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 118470383 Pathogen - hypothetical protein MSMEG_5034 1 None None None 118469293 Common - acyltransferase domain protein MSMEG_5742 4 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 118470302 Common - methyltransferase, putative, family protein MSMEG_1479 28 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118468345 Common - DNA-binding protein MSMEG_1631 41 None None None 118469829 Common - ankyrin-repeat containing protein MSMEG_1266 4 None None None 118473511 Common - IS6120, transposase MSMEG_1731 83 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 118471760 Common - hypothetical protein MSMEG_6737 1 None None None 118473495 Common - putative transporter MSMEG_0646 154 COG3639 COG3639, ABC-type phosphate/phosphonate transport system, permease component Inorganic ion transport and metabolism 118472111 Common - putative cytochrome P450 144 MSMEG_0675 76 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118467992 Common - integral membrane protein MviN, putative MSMEG_6929 152 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 118470379 Common - membrane protein MSMEG_1793 10 None None None 118473819 Common - hypothetical protein MSMEG_5988 1 COG4982 COG4982, 3-oxoacyl- acyl-carrier protein 118467507 Common - hypothetical protein MSMEG_4752 3 None None None 118468561 Common - probable conserved transmembrane protein, putative MSMEG_0172 3 None None None 118468423 Common - formamidopyrimidine-DNA glycosylase MSMEG_5545 179 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 118470813 Common - thiocyanate hydrolase gamma subunit MSMEG_6267 21 None None None 118470199 Common - acyl-CoA synthase MSMEG_1982 220 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118470396 Common - isoflavone reductase MSMEG_3384 11 COG1748 LYS9, Saccharopine dehydrogenase and related proteins Amino acid transport and metabolism 118473160 Common rpsC 30S ribosomal protein S3 MSMEG_1442 248 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 118468894 Common - hypothetical protein MSMEG_5929 15 COG5036 COG5036, SPX domain-containing protein involved in vacuolar polyphosphate accumulation Inorganic ion transport and metabolism 118468985 Common - O-succinylbenzoic acid--CoA ligase MSMEG_1062 215 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118472635 Common - hypothetical protein MSMEG_0754 14 None None None 118467407 Common - ferredoxin-dependent glutamate synthase MSMEG_5594 205 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 118470953 Pathogen - hypothetical protein MSMEG_3294 1 None None None 118469696 Common ispD 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase MSMEG_6076 198 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 118471797 Common - cadmium inducible protein cadi MSMEG_1174 26 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 118470897 Common - Thioesterase domain protein MSMEG_4514 43 COG3208 GrsT, Predicted thioesterase involved in non-ribosomal peptide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118468546 Common - transcriptional regulatory protein DegU MSMEG_1494 212 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118468771 Common - carboxyvinyl-carboxyphosphonate phosphorylmutase MSMEG_6855 131 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 118470101 Common rpsR 30S ribosomal protein S18 MSMEG_6895 210 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 118469932 Common - 4-hydroxyacetophenone monooxygenase MSMEG_3832 59 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118473534 Common secG preprotein translocase subunit SecG MSMEG_3087 6 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 118472853 Common - putative non-ribosomal peptide synthase MSMEG_0401 78 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118472606 Common - NADH dehydrogenase subunit J MSMEG_2054 48 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 118473791 Common - alkaline phosphatase MSMEG_5508 59 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 118469968 Common - hypothetical protein MSMEG_1644 2 None None None 118469075 Common asnB asparagine synthase (glutamine-hydrolyzing) MSMEG_4269 151 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 118469598 Common - amidohydrolase family protein MSMEG_2235 19 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118469550 Pathogen - hypothetical protein MSMEG_0726 1 None None None 118472627 Common - hydrolase, putative MSMEG_2902 66 COG0388 COG0388, Predicted amidohydrolase General function prediction only 118469740 Common - hypothetical protein MSMEG_4407 2 None None None 118470666 Common - trap-t family protein transporter, dctp MSMEG_6844 117 COG1638 DctP, TRAP-type C4-dicarboxylate transport system, periplasmic component Carbohydrate transport and metabolism 118473914 Common - putative DNA repair polymerase MSMEG_1622 27 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 118472425 Common - putative transport protein MSMEG_3369 160 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118472466 Common - hydroxyquinol 1,2-dioxygenase MSMEG_4041 46 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 118467706 Common narJ nitrate reductase molybdenum cofactor assembly chaperone MSMEG_5138 50 COG2180 NarJ, Nitrate reductase delta subunit Energy production and conversion 118471664 Common - 2,4-dienoyl-coA reductase MSMEG_5124 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 118471832 Pathogen - hypothetical protein MSMEG_1198 1 None None None 118467445 Common - hypothetical protein MSMEG_1247 1 None None None 118469687 Common - endoribonuclease L-PSP, putative MSMEG_3782 178 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 118469470 Common - hypothetical protein MSMEG_2421 7 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 118472069 Common - putative ABC transporter periplasmic oligopeptide-binding protein MSMEG_6124 201 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 118468518 Common - hydrolase, nudix family protein MSMEG_2936 19 COG1704 LemA, Uncharacterized conserved protein Function unknown 118467534 Pathogen - hypothetical protein MSMEG_1099 1 None None None 118473776 Common - carboxyvinyl-carboxyphosphonate phosphorylmutase MSMEG_2506 131 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 118471158 Common - transcriptional regulator, putative MSMEG_2164 134 COG2186 FadR, Transcriptional regulators Transcription 118472446 Common - acyl-CoA dehydrogenase MSMEG_4094 46 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472379 Common - hypothetical protein MSMEG_5238 4 None None None 118469974 Common - O-acetylhomoserine/O-acetylserine sulfhydrylase MSMEG_0238 117 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 118473436 Common - acetylornithine deacetylase MSMEG_2491 194 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 118469591 Common - polyketide synthase MSMEG_6392 210 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118472014 Common - putative amino acid decarboxylase, Pyridoxal-dependent protein MSMEG_3506 87 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 118468578 Common - two-component system response regulator MSMEG_0983 181 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118471565 Common glpX fructose 1,6-bisphosphatase II MSMEG_5239 112 COG1494 GlpX, Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins Carbohydrate transport and metabolism 118472364 Common rbfA ribosome-binding factor A MSMEG_2629 39 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 118469206 Common - hypothetical protein MSMEG_5321 1 None None None 118469988 Common - sensor histidine kinase MSMEG_2915 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 118469155 Common - oligopeptide ABC transporter integral membrane protein MSMEG_6867 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 161598319 Common - 3-ketosteroid-delta-1-dehydrogenase MSMEG_5941 64 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 118469692 Pathogen - hypothetical protein MSMEG_6200 1 None None None 118468729 Common - ppe family protein MSMEG_0619 1 COG5651 COG5651, PPE-repeat proteins Cell motility and secretion 118472545 Common - [Mn] superoxide dismutase MSMEG_6636 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 118469941 Common - dihydroxyacetone kinase MSMEG_6788 77 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 118467856 Common - conserved membrane-spanning protein MSMEG_5278 16 COG4425 COG4425, Predicted membrane protein Function unknown 118471397 Common - putative transcriptional regulator MSMEG_2106 10 COG1309 AcrR, Transcriptional regulator Transcription 118472024 Common - pyridoxamine 5'-phosphate oxidase family protein MSMEG_6576 10 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 118467653 Common - short chain dehydrogenase MSMEG_4872 232 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118468554 Pathogen - hypothetical protein MSMEG_2139 1 None None None 118468336 Common - hypothetical protein MSMEG_5843 9 None None None 118473294 Common - N-carbamoyl-L-amino acid amidohydrolase MSMEG_3995 84 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 118468749 Common - transcriptional regulator, TetR family protein, putative MSMEG_2406 8 COG1309 AcrR, Transcriptional regulator Transcription 118470538 Common hypC hydrogenase assembly chaperone HypC/HupF MSMEG_2712 23 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 118470126 Pathogen - hypothetical protein MSMEG_4054 1 None None None 118467471 Common - glucokinase MSMEG_1363 121 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 118467716 Common - MmpL5 protein MSMEG_4383 59 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118471978 Common - glutathione S-transferase domain protein MSMEG_2757 43 COG3502 COG3502, Uncharacterized protein conserved in bacteria Function unknown 118470364 Common - 5,10-methenyltetrahydrofolate synthetase MSMEG_5472 168 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 118470985 Common - dehydrogenase MSMEG_1794 29 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118468798 Common - hypothetical protein MSMEG_3339 3 None None None 118469051 Common - putative IclR family protein transcriptional regulator MSMEG_2025 117 COG1414 IclR, Transcriptional regulator Transcription 118469308 Common - regulatory protein GntR, HTH MSMEG_5201 94 COG2186 FadR, Transcriptional regulators Transcription 118468835 Common - hypothetical protein MSMEG_1246 11 None None None 118471100 Common - ATP/GTP-binding protein MSMEG_3321 36 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118469176 Common - hypothetical protein MSMEG_4348 196 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 118471127 Common - bacterial type II secretion system protein F domain MSMEG_6167 3 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion 118473187 Common - ribose transport ATP-binding protein RbsA MSMEG_3602 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 118472085 Common - probable transcriptional regulatory protein MSMEG_0120 101 COG1309 AcrR, Transcriptional regulator Transcription 118468591 Common - IS1096, tnpR protein MSMEG_2338 44 None None None 118468972 Common - putative acyl-CoA dehydrogenase MSMEG_0603 151 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118470618 Common - hypothetical protein MSMEG_3471 127 COG0807 RibA, GTP cyclohydrolase II Coenzyme metabolism 118473775 Common - PhoH family protein MSMEG_5247 198 COG1875 COG1875, Predicted ATPase related to phosphate starvation-inducible protein PhoH Signal transduction mechanisms 118473727 Common ruvB Holliday junction DNA helicase B MSMEG_2945 217 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 118470194 Common thiO glycine oxidase ThiO MSMEG_0791 91 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 118470925 Common - hypothetical protein MSMEG_1489 7 None None None 118470522 Common leuD isopropylmalate isomerase small subunit MSMEG_2388 210 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 118470957 Common - Transposase IS116/IS110/IS902 family protein MSMEG_3341 31 None None None 118471063 Common - transcriptional regulator, AraC family protein MSMEG_1106 151 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 118468629 Common - metal-dependent phosphohydrolase, HD subdomain MSMEG_3357 16 COG4341 COG4341, Predicted HD phosphohydrolase General function prediction only 118471106 Common - hypothetical protein MSMEG_2392 11 COG1920 COG1920, Uncharacterized conserved protein Function unknown 118470782 Common - putative ferredoxin FdxA MSMEG_1124 138 COG1146 COG1146, Ferredoxin Energy production and conversion 118473602 Common - dioxygenase, TauD/TfdA family protein MSMEG_0291 49 COG2175 TauD, Probable taurine catabolism dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 118468842 Common - short chain dehydrogenase MSMEG_4280 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118469404 Common ndh NADH dehydrogenase MSMEG_3621 191 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 118467883 Common - Tat (twin-arginine translocation) pathway signal sequence domain protein MSMEG_2623 1 None None None 118468367 Common ffh signal recognition particle protein MSMEG_2430 246 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 118467630 Common sppA signal peptide peptidase SppA, 67K type MSMEG_1476 186 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 118469956 Common - D-methionine transport ATP-binding protein MetN MSMEG_5807 249 COG1135 AbcC, ABC-type metal ion transport system, ATPase component Inorganic ion transport and metabolism 118472896 Common - hypothetical protein MSMEG_1588 1 None None None 118471021 Common - polyketide cyclase MSMEG_2947 58 COG1878 COG1878, Predicted metal-dependent hydrolase General function prediction only 118468740 Common gmk guanylate kinase MSMEG_3051 214 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 118472609 Common prfC peptide chain release factor 3 MSMEG_1316 249 COG4108 PrfC, Peptide chain release factor RF-3 Translation, ribosomal structure and biogenesis 118470431 Common groES co-chaperonin GroES MSMEG_1582 216 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 118470166 Common - ABC nitrate/sulfonate/bicarbonate family protein transporter, periplasmic ligand binding protein MSMEG_4586 39 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 118473516 Common - TetR-family protein transcriptional regulator MSMEG_5190 45 COG1309 AcrR, Transcriptional regulator Transcription 118473762 Common - regulatory protein MSMEG_1928 126 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 118468778 Common - adenylate cyclase, putative MSMEG_4302 15 COG5607 COG5607, Uncharacterized conserved protein Function unknown 118470679 Common - EthD protein MSMEG_1307 13 None None None 118469139 Common - hypothetical protein MSMEG_3977 43 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118470611 Common - glycosyl transferase, family protein 2 MSMEG_5962 47 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 118471124 Common argH argininosuccinate lyase MSMEG_3769 216 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 118469616 Common - pyruvate dehydrogenase alpha subunit MSMEG_2471 188 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 118469218 Pathogen - hypothetical protein MSMEG_3703 1 None None None 118472130 Common ehuA ectoine/hydroxyectoine ABC transporter, ATP-binding protein MSMEG_5371 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 118471774 Common - hypothetical protein MSMEG_5849 41 COG4328 COG4328, Uncharacterized protein conserved in bacteria Function unknown 118472418 Common - DNA-binding protein MSMEG_1151 125 COG1396 HipB, Predicted transcriptional regulators Transcription 118468793 Common - cytochrome P450 monooxygenase MSMEG_3693 84 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118473169 Common - short chain dehydrogenase MSMEG_6011 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118473966 Common rplI 50S ribosomal protein L9 MSMEG_6894 214 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 118473302 Common - transcriptional regulator, LuxR family protein MSMEG_0545 1 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 118469351 Pathogen - hypothetical protein MSMEG_6637 1 None None None 118472744 Common - Fatty acid desaturase MSMEG_6835 31 COG3239 DesA, Fatty acid desaturase Lipid metabolism 118472217 Pathogen - hypothetical protein MSMEG_1814 1 None None None 118474020 Common - CoA-binding protein MSMEG_4075 141 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 118470046 Common - hypothetical protein MSMEG_4195 3 None None None 118472717 Common - hypothetical protein MSMEG_1241 2 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 118472473 Common - membrane protein, MmpL family protein MSMEG_0250 36 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118467480 Common - permease, major facilitator family protein MSMEG_0534 112 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118470744 Common - transcriptional regulator MSMEG_1902 185 COG0583 LysR, Transcriptional regulator Transcription 118469284 Common - hypothetical protein MSMEG_6944 179 COG0759 COG0759, Uncharacterized conserved protein Function unknown 118468127 Common - secreted cell wall-associated hydrolase MSMEG_3145 91 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 118471405 Common - phenolpthIocerol synthesis type-i polyketide synthase ppse MSMEG_3168 1 None None None 118469663 Common - pyridoxamine 5'-phosphate oxidase family protein MSMEG_2791 5 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 118472751 Pathogen - hypothetical protein MSMEG_5543 1 None None None 118471558 Common - hypothetical protein MSMEG_3164 1 None None None 118468159 Common - IS1096, tnpA protein MSMEG_3166 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118472679 Common - hypothetical protein MSMEG_1188 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 118472092 Common - transport protein MSMEG_1007 42 COG0730 COG0730, Predicted permeases General function prediction only 118471168 Common - hypothetical protein MSMEG_1191 2 None None None 118472071 Common - Integral membrane protein MSMEG_4473 85 COG1814 COG1814, Uncharacterized membrane protein Function unknown 118469065 Common - inner membrane permease YgbN MSMEG_0452 74 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 118471429 Common - hypothetical protein MSMEG_0997 10 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 118471075 Pathogen - hypothetical protein MSMEG_4050 1 None None None 118467762 Common - hypothetical protein MSMEG_2115 10 None None None 118468540 Common - cytochrome D ubiquinol oxidase subunit 1 MSMEG_3233 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 118471643 Common - 4Fe-4S ferredoxin, iron-sulfur binding MSMEG_5533 30 COG1146 COG1146, Ferredoxin Energy production and conversion 118470947 Common - hypothetical protein MSMEG_4733 1 None None None 118470787 Common - hypothetical protein MSMEG_2481 10 None None None 118471506 Common - ribonuclease Z MSMEG_1776 116 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 118471545 Common - 5'-nucleotidase MSMEG_4308 180 COG0546 Gph, Predicted phosphatases General function prediction only 118468265 Common - hypothetical protein MSMEG_5992 32 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 118470974 Common - hypothetical protein MSMEG_1629 1 None None None 118469030 Common - Penicillin binding protein transpeptidase domain protein MSMEG_0031 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 118472535 Common - 4-hydroxy-2-oxovalerate aldolase MSMEG_2565 75 COG3836 HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase Carbohydrate transport and metabolism 118469338 Common dapB dihydrodipicolinate reductase MSMEG_2664 217 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 118471939 Common ligB ATP-dependent DNA ligase MSMEG_2277 109 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 118470910 Common - aminoglycosides/tetracycline-transport integral membrane protein MSMEG_3069 222 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118473877 Common - Penicillin binding protein transpeptidase domain protein MSMEG_4384 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 118471983 Common - cysteine desulfurase MSMEG_3125 237 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 118470056 Common - hypothetical protein MSMEG_6165 3 None None None 118468093 Common - hypothetical protein MSMEG_2186 52 COG3665 COG3665, Uncharacterized conserved protein Function unknown 118471073 Common - L-xylulose reductase MSMEG_3262 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118468722 Common lgt prolipoprotein diacylglyceryl transferase MSMEG_5408 87 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 118471114 Common - hypothetical protein MSMEG_5468 3 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 118467478 Common - transmembrane efflux protein MSMEG_2848 179 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118471431 Common - 4-amino-4-deoxychorismate lyase MSMEG_5795 105 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 118471391 Common - hypothetical protein MSMEG_2156 48 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118470508 Common - hypothetical protein MSMEG_6209 3 None None None 118472857 Common - dehydrogenase MSMEG_0600 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470778 Common - deoxyribonuclease MSMEG_5440 232 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 118471450 Common rplM 50S ribosomal protein L13 MSMEG_1556 233 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 118471055 Common sucB dihydrolipoamide acetyltransferase MSMEG_4283 194 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 118468474 Common - integral membrane protein MSMEG_0419 10 None None None 118471415 Common - L-carnitine dehydratase/bile acid-inducible protein F MSMEG_3391 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118472268 Common - phosphohistidine phosphatase MSMEG_5006 51 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 118468766 Common - hypothetical protein MSMEG_5237 86 COG0628 PerM, Predicted permease General function prediction only 118470481 Common - hypothetical protein MSMEG_5919 8 None None None 118470961 Common - beta-lactamase MSMEG_6784 148 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 118472516 Common - benzoate 1,2-dioxygenase alpha subunit MSMEG_1908 81 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 118467433 Common - alcohol dehydrogenase B MSMEG_5866 192 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 118472504 Common sufB FeS assembly protein SufB MSMEG_3122 186 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 118473674 Pathogen - hypothetical protein MSMEG_2401 1 None None None 118472168 Common trpC indole-3-glycerol-phosphate synthase MSMEG_3219 219 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 118473019 Common - DNA-binding response regulator MSMEG_5488 226 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 118467767 Common - Citrate transporter MSMEG_6072 11 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 118470445 Common - hypothetical protein MSMEG_6237 5 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118473660 Common - hypothetical protein MSMEG_0757 1 None None None 118472287 Common - putative acyl-CoA dehydrogenase MSMEG_4875 101 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473648 Common - integral membrane transporter MSMEG_1023 86 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 118469495 Common - hypothetical protein MSMEG_1263 1 None None None 118472685 Common - aldo/keto reductase MSMEG_4654 197 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 118472624 Common cdd cytidine deaminase MSMEG_1673 110 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 118469222 Common - glycerate kinase MSMEG_2528 81 COG1929 COG1929, Glycerate kinase Carbohydrate transport and metabolism 118469623 Common - acetolactate synthase MSMEG_1488 220 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 118468781 Common - hypothetical protein MSMEG_6411 2 None None None 118472595 Common - probable conserved transmembrane protein MSMEG_1110 5 None None None 118469774 Common - amidohydrolase family protein MSMEG_4773 14 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118469543 Common - ferredoxin MSMEG_5122 143 COG1146 COG1146, Ferredoxin Energy production and conversion 118471310 Common - hypothetical protein MSMEG_5946 6 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 118471005 Common - transcriptional regulator, MerR family protein MSMEG_3646 20 COG0789 SoxR, Predicted transcriptional regulators Transcription 118471571 Common - hypothetical protein MSMEG_3526 44 COG2128 COG2128, Uncharacterized conserved protein Function unknown 118469340 Common - DNA-binding protein MSMEG_0260 41 COG1396 HipB, Predicted transcriptional regulators Transcription 118468356 Common - hypothetical protein MSMEG_0692 7 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 118470883 Common - transposase A MSMEG_4155 178 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 118469213 Common - acyl-CoA synthetase MSMEG_5908 220 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118469243 Common - hypothetical protein MSMEG_0325 2 None None None 118473429 Common - hypothetical RNA methyltransferase MSMEG_2773 179 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 118469739 Common - hypothetical protein MSMEG_5357 4 None None None 118473151 Common - conserved hypothetical protein TIGR00026 MSMEG_2027 11 None None None 118470869 Common - glycerol-phosphate porter MSMEG_0508 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 118467925 Common - ABC-type molybdenum transport system, ATPase component MSMEG_1046 249 COG1119 ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA Inorganic ion transport and metabolism 118472860 Common - mycothiol conjugate amidase Mca MSMEG_5261 23 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 118468407 Common - malyl-CoA lyase MSMEG_6298 106 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 118471339 Common hup DNA-binding protein HU MSMEG_2389 189 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 118471744 Common - FAD binding domain, putative MSMEG_4870 56 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 118469721 Common tilS tRNA(Ile)-lysidine synthetase MSMEG_6111 190 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 118471857 Pathogen - hypothetical protein MSMEG_3539 1 None None None 118472495 Pathogen - hypothetical protein MSMEG_2802 1 None None None 118468887 Common - Cof protein MSMEG_4434 129 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 118473054 Common - TROVE domain protein MSMEG_1193 6 None None None 118472911 Common - cyclopropane-fatty-acyl-phospholipid synthase 1 MSMEG_1205 126 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 118467617 Common - linear gramicidin synthetase subunit C MSMEG_3715 214 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118468819 Pathogen - hypothetical protein MSMEG_4068 1 None None None 118471701 Common - sensor histidine kinase MSMEG_1493 143 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 118469865 Common - DeoR-family protein transcriptional regulator MSMEG_1359 78 COG2378 COG2378, Predicted transcriptional regulator Transcription 118473750 Common - putative multidrug resistance protein MSMEG_1455 131 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118471090 Common - Roadblock/LC7 domain protein MSMEG_1638 9 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 118472571 Pathogen - hypothetical protein MSMEG_5769 1 None None None 118469344 Common - 4-hydroxy-2-ketovalerate aldolase MSMEG_4150 165 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 118473599 Common - hypothetical protein MSMEG_0437 71 COG1738 COG1738, Uncharacterized conserved protein Function unknown 118469600 Pathogen - hypothetical protein MSMEG_3688 1 None None None 118468202 Common - bacterial alkaline phosphatase MSMEG_2292 84 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 118472705 Pathogen - hypothetical protein MSMEG_1933 1 None None None 118473370 Common - hypothetical protein MSMEG_2340 1 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 118470635 Common aspA aspartate ammonia-lyase MSMEG_1677 234 COG1027 AspA, Aspartate ammonia-lyase Amino acid transport and metabolism 118472328 Common tag DNA-3-methyladenine glycosylase I MSMEG_5082 132 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 118472873 Common - hypothetical protein MSMEG_0057 2 None None None 118471085 Common - major facilitator superfamily protein MFS_1, putative MSMEG_1329 117 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118470145 Common - putative esterase family protein MSMEG_3797 25 COG0627 COG0627, Predicted esterase General function prediction only 118472578 Common - N-acyl-D-glutamate amidohydrolase MSMEG_6141 58 COG3653 COG3653, N-acyl-D-aspartate/D-glutamate deacylase Secondary metabolites biosynthesis, transport, and catabolism 118473443 Pathogen - hypothetical protein MSMEG_6501 1 None None None 118473643 Common - hypothetical protein MSMEG_3017 88 COG2308 COG2308, Uncharacterized conserved protein Function unknown 118472490 Pathogen - hypothetical protein MSMEG_1256 1 None None None 118470714 Common - MmpS5 protein MSMEG_3495 1 None None None 118473759 Common - ubiquinol-cytochrome c reductase iron-sulfur subunit MSMEG_4262 27 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 118470643 Common - nitrile hydratase MSMEG_0377 18 None None None 118471996 Common - rhomboid family protein MSMEG_4904 29 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 118473470 Common - hypothetical protein MSMEG_5211 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 118467787 Common pyk pyruvate kinase MSMEG_0154 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 118469569 Pathogen - YesF protein MSMEG_3835 2 None None None 118472823 Common - transcriptional regulator, MerR family protein MSMEG_1447 134 COG0789 SoxR, Predicted transcriptional regulators Transcription 118470172 Common - esterase MSMEG_3059 137 COG0657 Aes, Esterase/lipase Lipid metabolism 118469710 Common - cytochrome P450 monooxygenase MSMEG_6622 69 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118467421 Common anmK anhydro-N-acetylmuramic acid kinase MSMEG_0189 120 COG2377 COG2377, Predicted molecular chaperone distantly related to HSP70-fold metalloproteases Posttranslational modification, protein turnover, chaperones 118468605 Common - hypothetical protein MSMEG_4399 3 None None None 118471626 Common - hypothetical protein MSMEG_0075 1 None None None 118468491 Common - virulence factor Mce family protein MSMEG_2856 20 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118468719 Common - 3-ketosteroid-delta-1-dehydrogenase MSMEG_2869 62 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 118472419 Common - ABC transporter efflux protein, DrrB family protein MSMEG_3763 77 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 118469257 Common - Penicillin binding protein transpeptidase domain protein MSMEG_4233 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 118468325 Common - metabolite/sugar transport protein MSMEG_5559 137 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118473854 Common - pe family protein MSMEG_5759 1 None None None 118471467 Common - hypothetical protein MSMEG_0976 1 None None None 118468195 Pathogen - putative adhesin/hemolysin MSMEG_5751 2 None None None 118474018 Common - RNA polymerase ECF-type sigma factor MSMEG_1418 97 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118469319 Common - hypothetical protein MSMEG_6231 2 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118472228 Common - multiphosphoryl transfer protein (MTP) MSMEG_2121 225 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 118471031 Common - ATPase family protein associated with various cellular activities (AAA) MSMEG_3867 172 COG0714 COG0714, MoxR-like ATPases General function prediction only 118468371 Common - NADH dehydrogenase subunit C MSMEG_2061 173 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 118473222 Pathogen - hypothetical protein MSMEG_0543 4 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 118472481 Common cynS cyanate hydratase MSMEG_5359 41 COG1513 CynS, Cyanate lyase Inorganic ion transport and metabolism 118467691 Common - sulfate permease MSMEG_6453 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 118470237 Common - 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_4004 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118473681 Common - ABC transporter, permease protein, putative MSMEG_6670 182 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 118471218 Pathogen - hypothetical protein MSMEG_5749 1 None None None 118470072 Common - transcriptional regulator, AraC family protein MSMEG_3488 129 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 118473828 Common - hypothetical protein MSMEG_4456 11 COG2128 COG2128, Uncharacterized conserved protein Function unknown 118470155 Common - MarR-family protein transcriptional regulator MSMEG_4471 38 COG1846 MarR, Transcriptional regulators Transcription 118469035 Common thpD ectoine hydroxylase MSMEG_3898 35 COG5285 COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin Secondary metabolites biosynthesis, transport, and catabolism 118469131 Common - spore protein MSMEG_5611 151 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 118469629 Common - hypothetical protein MSMEG_4317 24 COG3826 COG3826, Uncharacterized protein conserved in bacteria Function unknown 118467833 Common - acyl-CoA synthetase MSMEG_4896 201 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118473484 Common - metallo-beta-lactamase family protein MSMEG_5385 197 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 118470751 Common - putative esterase family protein MSMEG_2314 27 COG0627 COG0627, Predicted esterase General function prediction only 118472198 Common - short chain dehydrogenase MSMEG_3607 238 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118471446 Pathogen - hypothetical protein MSMEG_4607 1 None None None 118467963 Common - efflux ABC transporter, permease protein, putative MSMEG_2523 1 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 118469448 Common pcaB 3-carboxy-cis,cis-muconate cycloisomerase MSMEG_2603 125 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 118473477 Common - hypothetical protein MSMEG_0616 8 None None None 118472993 Common - nitrate reductase, alpha subunit MSMEG_5140 104 COG5013 NarG, Nitrate reductase alpha subunit Energy production and conversion 118471232 Common - hypothetical protein MSMEG_3418 4 None None None 118473471 Common - AMP-dependent synthetase and ligase MSMEG_0326 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118469779 Pathogen - hypothetical protein MSMEG_1674 1 None None None 118471961 Common - ABC transporter, ATP-binding protein MSMEG_1502 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 118468469 Common - regulatory protein, MarR MSMEG_5338 53 COG1846 MarR, Transcriptional regulators Transcription 118471252 Common ssuD nitrilotriacetate monooxygenase component A MSMEG_2842 71 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118472530 Common - amino acid ABC transporter, permease protein MSMEG_6332 82 COG1174 OpuBB, ABC-type proline/glycine betaine transport systems, permease component Amino acid transport and metabolism 118470207 Pathogen - hypothetical protein MSMEG_5771 1 None None None 118472562 Pathogen - hypothetical protein MSMEG_1664 1 None None None 118469658 Common - ABC transporter, ATP-binding protein MSMEG_5659 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 118469850 Common - dehydrogenase/reductase SDR family protein member 1 MSMEG_2923 94 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470500 Common - TetR-family protein transcriptional regulator MSMEG_1935 132 COG1309 AcrR, Transcriptional regulator Transcription 118467941 Pathogen - RNA polymerase sigma-70 factor MSMEG_5365 1 None None None 118467644 Common - hypothetical protein MSMEG_4739 5 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 118470629 Common - DeoR-family protein transcriptional regulator MSMEG_0503 115 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 118468183 Common - hypothetical protein MSMEG_5101 1 None None None 118468089 Common - pyridoxamine 5'-phosphate oxidase family protein MSMEG_5819 4 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 118471362 Common - hypothetical protein MSMEG_5083 6 None None None 118468903 Common sdhA succinate dehydrogenase flavoprotein subunit MSMEG_0418 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 118468152 Common - acetylornithine deacetylase MSMEG_3397 163 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 118471282 Common rpmG ribosomal protein L33 MSMEG_1339 79 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 118471763 Common - D-alanyl-D-alanine dipeptidase MSMEG_5879 30 COG2173 DdpX, D-alanyl-D-alanine dipeptidase Cell envelope biogenesis, outer membrane 118469929 Common - Glycosyltransferase family protein 28 MSMEG_4740 24 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 118469312 Pathogen - hypothetical protein MSMEG_2250 1 None None None 118474038 Common - oxidoreductase MSMEG_0870 119 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 118471820 Common - hypothetical protein MSMEG_3801 3 None None None 118469410 Common - LprB protein MSMEG_5007 3 None None None 118472305 Common - virulence factor Mce family protein MSMEG_0134 6 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118473493 Common - FAD dependent oxidoreductase MSMEG_1604 65 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 118473022 Common - acyl carrier protein MSMEG_2132 9 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118471853 Common - epoxide hydrolase 1 MSMEG_6858 47 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118468663 Common hisG ATP phosphoribosyltransferase MSMEG_4180 213 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 118468681 Pathogen - hypothetical protein MSMEG_5787 1 None None None 118471690 Common - feruloyl-CoA synthetase MSMEG_3694 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118468955 Common - secreted peptidase MSMEG_0247 73 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 118470251 Common - putative HTH-type transcriptional regulator MSMEG_6908 82 COG1802 GntR, Transcriptional regulators Transcription 118473869 Common - secreted protein MSMEG_6815 7 None None None 118468460 Common - short chain dehydrogenase MSMEG_6916 147 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118473264 Pathogen - hypothetical protein MSMEG_3537 1 None None None 118472261 Common - putative oxidoreductase MSMEG_1511 20 COG0778 NfnB, Nitroreductase Energy production and conversion 118469425 Common - DEAD/DEAH box helicase MSMEG_1930 242 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 118470800 Common - urease accessory protein UreF MSMEG_1092 9 COG0830 UreF, Urease accessory protein UreF Posttranslational modification, protein turnover, chaperones 118468737 Common - M23 peptidase domain protein MSMEG_1192 112 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 118472954 Common - transcriptional regulator MSMEG_3606 66 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 118471866 Common - transcriptional regulator, TetR family protein MSMEG_2995 12 COG1309 AcrR, Transcriptional regulator Transcription 118468101 Common - enoyl-CoA hydratase MSMEG_4709 113 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118471588 Common - oxidoreductase MSMEG_6342 16 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 118472094 Common - hypothetical protein MSMEG_2311 14 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 118473096 Common - cyclohexadienyl dehydratase MSMEG_3442 152 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 118473881 Common - hypothetical protein MSMEG_3855 2 None None None 118468688 Common - cytochrome P450 MSMEG_6695 85 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118474011 Common - acetyltransferase MSMEG_0773 43 COG0456 RimI, Acetyltransferases General function prediction only 118468541 Common ltaE L-threonine aldolase, low-specificity MSMEG_4454 115 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 118470026 Common gpsA NAD(P)H-dependent glycerol-3-phosphate dehydrogenase MSMEG_2393 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 118473647 Common - malyl-CoA lyase MSMEG_6644 117 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 118467608 Common - trap dicarboxylate transporter, dctq subunit, putative MSMEG_3349 7 COG4665 FcbT2, TRAP-type mannitol/chloroaromatic compound transport system, small permease component Secondary metabolites biosynthesis, transport, and catabolism 118472127 Common - ABC transporter ATP-binding protein MSMEG_0488 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 118468674 Common - 5,10-methylenetetrahydromethanopterin reductase MSMEG_2103 36 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118471325 Common - hypothetical protein MSMEG_3500 65 COG3022 COG3022, Uncharacterized protein conserved in bacteria Function unknown 118473043 Pathogen - hypothetical protein MSMEG_4848 1 None None None 118473405 Common smpB SsrA-binding protein MSMEG_2091 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 118470331 Common - short-chain dehydrogenase/reductase SDR MSMEG_3302 233 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118472906 Common - hypothetical protein MSMEG_2270 1 None None None 118473012 Pathogen - hypothetical protein MSMEG_5217 1 None None None 118471576 Pathogen - LysM domain protein MSMEG_3288 1 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 118469795 Pathogen - hypothetical protein MSMEG_6675 1 None None None 118472290 Common - alcohol dehydrogenase, zinc-containing MSMEG_4400 185 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 118472155 Common - alpha/beta hydrolase fold MSMEG_6658 44 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118472944 Common - ThiS family protein MSMEG_5699 11 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 118471216 Common - probable transcriptional regulatory protein MSMEG_5074 12 COG1309 AcrR, Transcriptional regulator Transcription 118468274 Common - glycogen synthase MSMEG_5080 220 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 118469876 Common - short chain dehydrogenase MSMEG_6385 184 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118468502 Common - hypothetical protein MSMEG_0914 8 None None None 118468624 Common - putative acetolactate synthase MSMEG_3389 219 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 118473821 Common - acyl-CoA dehydrogenase domain protein MSMEG_3392 156 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118469828 Common - DEAD/DEAH box helicase MSMEG_1254 121 COG1205 COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster General function prediction only 118472178 Common - NADH:flavin oxidoreductase/nadh oxidase MSMEG_6603 22 None None None 118471481 Common - putative oxidoreductase MSMEG_2516 45 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118470039 Common - chaperone ClpB MSMEG_0732 215 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 118470993 Pathogen - hypothetical protein MSMEG_0557 1 None None None 118472611 Common - inner membrane permease YgbN MSMEG_3789 84 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 118472301 Common - ATP-dependent DNA helicase MSMEG_1943 221 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 118473944 Common - maltose/maltodextrin-binding protein MSMEG_3266 60 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118473332 Common - hypothetical protein MSMEG_6251 1 None None None 118467749 Common - integral membrane protein MSMEG_6273 8 None None None 118471678 Common - GAF domain protein, putative MSMEG_6492 63 COG3835 CdaR, Sugar diacid utilization regulator Transcription / Signal transduction mechanisms 118472972 Common - transcriptional regulator MSMEG_0213 126 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 118468434 Common - methyltransferase MSMEG_3286 158 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118473118 Common - transcriptional regulatory protein MSMEG_4242 15 None None None 118470191 Common crcB CrcB protein MSMEG_2134 11 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 118472241 Common - alpha-amylase family protein MSMEG_4696 146 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 118467667 Common - hypothetical protein MSMEG_1774 15 None None None 118467400 Common - fumarylacetoacetate MSMEG_6588 135 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 118470214 Common - hypothetical protein MSMEG_4898 7 COG4578 GutM, Glucitol operon activator Transcription 118468386 Common - cation ABC transporter, ATP-binding protein, putative MSMEG_6046 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 118468223 Common - hydrolase, nudix family protein, putative MSMEG_1827 15 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 118469793 Common - acyl-CoA dehydrogenase MSMEG_0714 164 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118467583 Common - L-carnitine dehydratase/bile acid-inducible protein F MSMEG_2468 110 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118473060 Common - integral membrane protein MSMEG_6570 56 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 118471376 Pathogen - hypothetical protein MSMEG_3315 1 None None None 118468016 Pathogen - hypothetical protein MSMEG_1083 1 None None None 118467979 Common - putative hydrolase MSMEG_2644 64 COG2936 COG2936, Predicted acyl esterases General function prediction only 118468934 Common lepA GTP-binding protein LepA MSMEG_4556 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 118468399 Common cobB cobyrinic acid a,c-diamide synthase MSMEG_2617 136 COG1797 CobB, Cobyrinic acid a,c-diamide synthase Coenzyme metabolism 118473958 Common - integration host factor MSMEG_3050 16 None None None 118470232 Common - glycoside hydrolase MSMEG_4535 69 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 118473846 Common - hypothetical protein MSMEG_5767 23 COG3662 COG3662, Uncharacterized protein conserved in bacteria Function unknown 118468228 Common - hypothetical protein MSMEG_6147 2 None None None 118467357 Common - hypothetical protein MSMEG_5836 6 COG3233 COG3233, Predicted deacetylase General function prediction only 118472135 Common - putative esterase family protein MSMEG_3437 45 COG0627 COG0627, Predicted esterase General function prediction only 118470040 Common - benzoylformate decarboxylase MSMEG_1606 222 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 118470389 Common - oxidoreductase, 2OG-Fe(II) oxygenase family protein MSMEG_1299 54 COG3491 PcbC, Isopenicillin N synthase and related dioxygenases General function prediction only 118471930 Common - thioesterase family protein MSMEG_2929 10 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 118468668 Common - DNA-binding protein MSMEG_3292 41 None None None 118468692 Common cmk cytidylate kinase MSMEG_3739 204 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 118470258 Common purK phosphoribosylaminoimidazole carboxylase ATPase subunit MSMEG_1819 193 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 118467503 Common - hypothetical protein MSMEG_1959 48 COG1615 COG1615, Uncharacterized conserved protein Function unknown 118468390 Common - hypothetical protein MSMEG_2417 37 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 118470902 Common - hypothetical protein MSMEG_5709 1 None None None 118468025 Common - manganese transport protein MntH MSMEG_5589 108 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 118473610 Common - TetR-family protein transcriptional regulator MSMEG_5340 15 COG1309 AcrR, Transcriptional regulator Transcription 118467816 Pathogen - hypothetical protein MSMEG_1130 1 COG1537 PelA, Predicted RNA-binding proteins General function prediction only 118471997 Pathogen - hypothetical protein MSMEG_1251 1 None None None 118469053 Common - hypothetical protein MSMEG_2999 42 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 118473556 Pathogen - hypothetical protein MSMEG_1687 1 None None None 118472189 Common - hypothetical protein MSMEG_5666 10 None None None 118473734 Common - hypothetical protein MSMEG_1917 148 COG1038 PycA, Pyruvate carboxylase Energy production and conversion 118468256 Common - cytosine deaminase MSMEG_4687 179 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 118468698 Common - enoyl-CoA hydratase MSMEG_0490 188 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118470874 Common - phosphomethylpyrimidine kinase MSMEG_0464 219 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 118473834 Common - DNA polymerase IV MSMEG_3172 184 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 118473029 Common - transcriptional regulator MSMEG_3959 65 COG1802 GntR, Transcriptional regulators Transcription 118467900 Common - hypothetical protein MSMEG_6207 5 None None None 118467550 Common - NAD-dependent formate dehydrogenase delta subunit MSMEG_0162 12 None None None 118471684 Common - carboxylate-amine ligase MSMEG_0836 68 COG2170 COG2170, Uncharacterized conserved protein Function unknown 118469586 Common - polysaccharide deacetylase MSMEG_2970 99 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 118468176 Common - hypothetical protein MSMEG_6346 1 None None None 118472403 Common - endonuclease VIII and dna n-glycosylase with an ap lyase activity MSMEG_1756 166 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 118471173 Common - C-5 sterol desaturase MSMEG_2812 72 COG3000 ERG3, Sterol desaturase Lipid metabolism 118471621 Common - secreted protein, putative MSMEG_0478 74 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 118467458 Common - integral membrane protein MSMEG_2325 29 COG2364 COG2364, Predicted membrane protein Function unknown 118470239 Common - phosphatidylinositol alpha-mannosyltransferase MSMEG_2935 195 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 118467873 Common - hypothetical protein MSMEG_5421 1 None None None 118470831 Common leuA 2-isopropylmalate synthase MSMEG_6271 210 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 118473924 Common - MmpS4 protein MSMEG_0380 1 None None None 118473560 Common - hypothetical protein MSMEG_0753 4 None None None 118473271 Common - hypothetical protein MSMEG_1379 97 COG0579 COG0579, Predicted dehydrogenase General function prediction only 118469274 Common - hypothetical protein MSMEG_4894 3 COG5373 COG5373, Predicted membrane protein Function unknown 118467684 Common - lipase MSMEG_2888 122 COG0657 Aes, Esterase/lipase Lipid metabolism 118471048 Common - acyl-CoA dehydrogenase MSMEG_1821 167 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118470496 Common - toluate 1,2-dioxygenase electron transfer component MSMEG_1906 241 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 118471530 Common - hypothetical protein MSMEG_5109 89 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 118467615 Common - hypothetical protein MSMEG_6539 11 None None None 118471470 Common - acyl-CoA thioesterase II MSMEG_3228 77 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 118473201 Common - pyruvate dehydrogenase MSMEG_3964 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 118468185 Common - 'Cold-shock' DNA-binding domain protein MSMEG_5696 168 COG1278 CspC, Cold shock proteins Transcription 118468868 Common - Rieske iron-sulfur protein MSMEG_6548 57 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 118470849 Common - hypothetical protein MSMEG_6699 3 None None None 118473631 Common - acetyltransferase MSMEG_4972 72 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 118471229 Pathogen - hypothetical protein MSMEG_1541 1 None None None 118472785 Common - chromosome condensation protein MSMEG_0089 145 COG1741 COG1741, Pirin-related protein General function prediction only 118470847 Common - hypothetical protein MSMEG_3128 2 None None None 118473432 Pathogen - hypothetical protein MSMEG_5326 1 None None None 118469606 Common - prephenate dehydrogenase MSMEG_6330 145 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 118470991 Common - pigment production hydroxylase MSMEG_2892 47 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472485 Common - hypothetical protein MSMEG_5128 4 None None None 118467540 Common - Sua5/YciO/YrdC/YwlC family protein MSMEG_4948 233 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 118473904 Common rplK 50S ribosomal protein L11 MSMEG_1346 246 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 118470482 Common - RNA polymerase sigma factor SigF MSMEG_1804 216 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 118470688 Common nudC NADH pyrophosphatase MSMEG_1946 104 COG2816 NPY1, NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding DNA replication, recombination, and repair 118473707 Common - LppU protein MSMEG_2655 3 None None None 118473577 Common - IS1096, tnpR protein MSMEG_2282 44 None None None 118467743 Common - glycine betaine/carnitine/choline transport ATP-binding protein opuCA MSMEG_2926 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 118471875 Common - transcriptional regulator MSMEG_3264 63 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 118470417 Common - base excision DNA repair protein, HhH-GPD family protein MSMEG_6083 200 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 118471226 Common fxsA FxsA MSMEG_3862 1 COG3030 FxsA, Protein affecting phage T7 exclusion by the F plasmid General function prediction only 118470086 Common - death-on-curing protein MSMEG_1278 52 COG3654 Doc, Prophage maintenance system killer protein General function prediction only 118467587 Common - transporter MSMEG_5473 146 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 118467822 Common arsB arsenical-resistance protein MSMEG_1172 129 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 118473542 Common - serine/threonine protein kinase MSMEG_3677 146 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 118467696 Common - hypothetical protein MSMEG_2668 1 None None None 118470766 Common - hypothetical protein MSMEG_5057 5 None None None 118471723 Common - 2,5-diketo-D-gluconic acid reductase A MSMEG_2408 184 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 118469063 Common - amidohydrolase 3 MSMEG_2431 71 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 118470354 Common - putative acyl-CoA dehydrogenase MSMEG_6014 133 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472792 Common - P450 heme-thiolate protein MSMEG_5918 82 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118473942 Common ligC ATP-dependent DNA ligase MSMEG_6302 106 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 118471102 Common - Pyridine nucleotide-disulphide oxidoreductase MSMEG_1460 227 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 118471654 Common - phenoxybenzoate dioxygenase beta subunit MSMEG_1989 110 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 118469194 Common - ATP synthase delta chain MSMEG_4939 104 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 118469521 Common - transcriptional regulator, TetR family protein MSMEG_0532 3 COG1309 AcrR, Transcriptional regulator Transcription 118468047 Common - hydride transferase 1 MSMEG_3609 55 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118469562 Common - transcriptional Regulator, TetR family protein MSMEG_5522 16 COG1309 AcrR, Transcriptional regulator Transcription 118472572 Common trx thioredoxin MSMEG_3138 230 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 118469525 Common - IS1096, tnpA protein MSMEG_0802 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118471492 Common - hypothetical protein MSMEG_3491 1 None None None 118468941 Common - transcriptional regulator, TetR family protein MSMEG_0148 50 COG1309 AcrR, Transcriptional regulator Transcription 118468163 Common - hypothetical protein MSMEG_5460 1 None None None 118473068 Common - integral membrane protein MSMEG_2796 20 COG1275 TehA, Tellurite resistance protein and related permeases Inorganic ion transport and metabolism 118468509 Common - antibiotic biosynthesis monooxygenase MSMEG_1532 16 COG1359 COG1359, Uncharacterized conserved protein Function unknown 118467385 Common - transposase subunit MSMEG_4089 135 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 118472345 Common - phospholipase, patatin family protein MSMEG_5285 29 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 118468276 Pathogen - hypothetical protein MSMEG_1961 1 None None None 118469208 Common - xylose repressor, putative MSMEG_3313 164 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 118473081 Common - hypothetical protein MSMEG_4777 28 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 118471896 Common - hypothetical protein MSMEG_0842 1 None None None 118473145 Common - transcriptional regulator, MarR family protein MSMEG_0448 116 COG1846 MarR, Transcriptional regulators Transcription 118470768 Common - 4-carboxy-4-hydroxy-2-oxoadipate aldolase MSMEG_0706 59 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 118472819 Common - IS1096, tnpA protein MSMEG_1003 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118472141 Common - oxidoreductase MSMEG_4971 96 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 118470393 Common - NAD(P) transhydrogenase beta subunit MSMEG_0150 122 COG1282 PntB, NAD/NADP transhydrogenase beta subunit Energy production and conversion 118468123 Common lipB lipoyltransferase MSMEG_4285 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 118468288 Common glgB glycogen branching enzyme MSMEG_4918 149 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 118473416 Common - hypothetical protein MSMEG_5308 42 COG3391 COG3391, Uncharacterized conserved protein Function unknown 118468239 Common arcA arginine deiminase MSMEG_1409 53 COG2235 ArcA, Arginine deiminase Amino acid transport and metabolism 118473745 Common - hypothetical protein MSMEG_6476 3 None None None 118471117 Common - membrane protein MSMEG_1923 4 None None None 118468311 Common - von Willebrand factor, type A MSMEG_5511 20 COG4867 COG4867, Uncharacterized protein with a von Willebrand factor type A (vWA) domain General function prediction only 118470963 Common - putative secreted alanine rich protein MSMEG_2761 5 None None None 118473900 Common - cyclase/dehydrase MSMEG_4251 8 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 118471053 Common - hypothetical protein MSMEG_4919 10 None None None 118471802 Common dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase MSMEG_2578 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 118470624 Common - binding-protein-dependent transport systems inner membrane component MSMEG_5808 106 COG2011 AbcD, ABC-type metal ion transport system, permease component Inorganic ion transport and metabolism 118471512 Common - polysulphide reductase, NrfD MSMEG_1846 7 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 118472733 Common - hypothetical protein MSMEG_3107 19 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 118469762 Common - NikQ protein MSMEG_2558 66 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118469552 Common - hypothetical protein MSMEG_5388 73 COG1937 COG1937, Uncharacterized protein conserved in bacteria Function unknown 118472672 Common - hypothetical protein MSMEG_3896 4 None None None 118471206 Common - hypothetical protein MSMEG_2826 10 None None None 118468426 Common - isochorismatase family protein MSMEG_4618 52 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 118468805 Common ccsB cytochrome c-type biogenesis protein CcsB MSMEG_0974 167 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 118472120 Common - O-succinylbenzoate synthase MSMEG_1103 70 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 118472828 Common - probable conserved transmembrane protein MSMEG_1394 1 None None None 118474031 Pathogen - hypothetical protein MSMEG_6696 1 None None None 118470544 Common - transcription regulator AmtR MSMEG_4300 101 COG1309 AcrR, Transcriptional regulator Transcription 118472840 Common rbsK ribokinase MSMEG_4585 121 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 118469112 Common - esterase MSMEG_2875 113 COG0657 Aes, Esterase/lipase Lipid metabolism 118473357 Common nuoM NADH dehydrogenase subunit M MSMEG_2051 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 118471239 Common serA D-3-phosphoglycerate dehydrogenase MSMEG_2378 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 118470604 Pathogen - hypothetical protein MSMEG_3849 1 None None None 118473052 Common - hypothetical protein MSMEG_3804 3 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 118471389 Common - ABC transporter, permease/ATP-binding protein MSMEG_4380 141 COG4178 COG4178, ABC-type uncharacterized transport system, permease and ATPase components General function prediction only 118470263 Common - AraC-family protein transcriptional regulator MSMEG_5563 139 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 118469149 Common - amino acid permease MSMEG_0781 151 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118468040 Common - DEAD/DEAH box helicase MSMEG_1757 202 COG1201 Lhr, Lhr-like helicases General function prediction only 118471517 Common - soluble secreted antigen MPT53 MSMEG_3543 51 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 118471641 Common - transcriptional regulator, TetR family protein MSMEG_4983 19 COG1309 AcrR, Transcriptional regulator Transcription 118471543 Common - hydroxylase MSMEG_5801 21 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118471320 Common kdpA potassium-transporting ATPase subunit A MSMEG_5392 96 COG2060 KdpA, K+-transporting ATPase, A chain Inorganic ion transport and metabolism 118470741 Common - oxidoreductase, Gfo/Idh/MocA family protein MSMEG_3300 131 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 118472279 Pathogen - hypothetical protein MSMEG_5097 1 None None None 118472356 Pathogen - hypothetical protein MSMEG_4416 1 None None None 118471275 Common - nitrilotriacetate monooxygenase component A MSMEG_1162 74 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118470229 Common - hypothetical protein MSMEG_3428 18 None None None 118468034 Common - ribonucleotide-diphosphate reductase subunit alpha MSMEG_2299 218 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 118469148 Common - short-chain dehydrogenase/reductase SDR MSMEG_2918 236 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118467451 Common - dehydrogenase MSMEG_6623 232 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118469502 Common - ABC transporter, permease protein MSMEG_0549 191 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 118467829 Common - oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_4125 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118473961 Common - probable membrane protein MSMEG_3504 1 None None None 118472922 Common - oligopeptide transport ATP-binding protein OppD MSMEG_0640 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 118472459 Common - cysteine desulfurase MSMEG_2357 232 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 118469460 Common - hypothetical protein MSMEG_3171 1 None None None 118473134 Common - TonB-dependent receptor MSMEG_3967 99 COG2378 COG2378, Predicted transcriptional regulator Transcription 118468889 Pathogen - hypothetical protein MSMEG_0598 1 None None None 118470656 Common - hypothetical protein MSMEG_0336 11 None None None 118468746 Common - hypothetical protein MSMEG_0050 2 None None None 118473939 Common - TetR-family protein transcriptional regulator MSMEG_5838 58 COG1309 AcrR, Transcriptional regulator Transcription 118469815 Common - transcriptional regulator, GntR family protein MSMEG_6745 109 COG2188 PhnF, Transcriptional regulators Transcription 118469250 Common - hypothetical protein MSMEG_3933 27 COG4908 COG4908, Uncharacterized protein containing a NRPS condensation (elongation) domain General function prediction only 118472644 Common - secreted protein MSMEG_6595 156 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 118468800 Common rpmB 50S ribosomal protein L28 MSMEG_2400 35 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 118473283 Common - transporter, major facilitator family protein MSMEG_6390 145 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118467927 Common - hypothetical protein MSMEG_2575 4 None None None 118469375 Common - ROK family protein MSMEG_0932 71 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 118470098 Common - cyclopropane-fatty-acyl-phospholipid synthase 1 MSMEG_3538 128 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 118470272 Pathogen - hypothetical protein MSMEG_4444 1 None None None 118468247 Common - YiaAB two helix domain protein MSMEG_6444 10 COG4298 COG4298, Uncharacterized protein conserved in bacteria Function unknown 118472877 Common - putative transcription regulator MSMEG_6862 32 COG1309 AcrR, Transcriptional regulator Transcription 118470289 Common - hypothetical protein MSMEG_4572 19 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 118470528 Pathogen - hypothetical protein MSMEG_4608 1 None None None 118468911 Common - hypothetical protein MSMEG_1823 13 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 118473100 Common - macrolide-transport ATP-binding protein abc transporter MSMEG_3768 248 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 118470377 Common - transcriptional regulator MSMEG_4768 6 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 118471562 Common - transcriptional regulator, MerR family protein MSMEG_3424 26 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118469424 Common - putative aliphatic sulfonates transport permease protein SsuC MSMEG_3854 192 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 118469091 Common - tetratricopeptide repeat family protein MSMEG_5088 6 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 118469747 Common - transcriptional regulator, TetR family protein MSMEG_5567 23 COG1309 AcrR, Transcriptional regulator Transcription 118473549 Common - transcriptional Regulator, GntR family protein MSMEG_2546 96 COG1802 GntR, Transcriptional regulators Transcription 118470346 Common - hypothetical protein MSMEG_3148 91 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 118470298 Common - urease accessory protein uref MSMEG_3624 15 COG0830 UreF, Urease accessory protein UreF Posttranslational modification, protein turnover, chaperones 118471990 Common - integral membrane protein MSMEG_3310 14 None None None 118471750 Common - permease binding-protein component MSMEG_2924 90 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 118470370 Common - alpha-ketoglutarate-dependent taurine dioxygenase MSMEG_0181 47 COG2175 TauD, Probable taurine catabolism dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 118472281 Common - transporter, small multidrug resistance (SMR) family protein MSMEG_3670 75 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 118472203 Common - Amidinotransferase MSMEG_1414 39 COG1834 COG1834, N-Dimethylarginine dimethylaminohydrolase Amino acid transport and metabolism 118472689 Common - feruloyl-CoA synthetase MSMEG_5633 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118468642 Pathogen - ornithine carbamoyltransferase MSMEG_4750 1 None None None 118471380 Common - putative acyl-CoA dehydrogenase MSMEG_5993 157 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118470315 Common - hypothetical protein MSMEG_6607 2 None None None 118468442 Common - hypothetical protein MSMEG_6667 13 COG4329 COG4329, Predicted membrane protein Function unknown 118472294 Common - phosphodiesterase MSMEG_3492 25 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 118469637 Common pruA 1-pyrroline-5-carboxylate dehydrogenase MSMEG_5119 218 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118472340 Common ureE urease accessory protein UreE MSMEG_1091 4 COG2371 UreE, Urease accessory protein UreE Posttranslational modification, protein turnover, chaperones 118467861 Common - retinol dehydrogenase 13 MSMEG_5430 214 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118472083 Pathogen - hypothetical protein MSMEG_0421 1 None None None 118467726 Common - putative NagC regulator MSMEG_0316 169 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 118472137 Common - aldo/keto reductase MSMEG_2920 204 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 118470701 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding MSMEG_3380 13 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 118470407 Common - hypothetical protein MSMEG_4311 37 COG3346 COG3346, Uncharacterized conserved protein Function unknown 118467362 Common rpoZ DNA-directed RNA polymerase subunit omega MSMEG_3053 21 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 118471358 Pathogen - hypothetical protein MSMEG_1785 1 None None None 118471038 Common - nicotine dehydrogenase MSMEG_5880 107 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 118473461 Common - hypothetical protein MSMEG_6434 5 None None None 118470502 Common - hypothetical protein MSMEG_4771 4 None None None 118469216 Common groEL chaperonin GroEL MSMEG_1583 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 118470451 Common - hypothetical protein MSMEG_1805 3 None None None 118471248 Common - hypothetical protein MSMEG_2076 39 COG2320 GrpB, Uncharacterized conserved protein Function unknown 118473684 Common - hypothetical protein MSMEG_5366 23 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118467487 Common - short-chain dehydrogenase/reductase SDR MSMEG_5714 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118469607 Pathogen - hypothetical protein MSMEG_2222 1 None None None 118472641 Common - stas domain, putative MSMEG_1786 1 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 118470664 Common - hypothetical protein MSMEG_3325 4 None None None 118471315 Common - Bacterial membrane flanked domain protein MSMEG_1818 17 COG3428 COG3428, Predicted membrane protein Function unknown 118469129 Common - integral membrane protein, putative MSMEG_3573 5 COG1276 PcoD, Putative copper export protein Inorganic ion transport and metabolism 118472693 Common - lipoprotein LpqH MSMEG_3803 3 None None None 118467602 Common - [NADP+] succinate-semialdehyde dehydrogenase MSMEG_6702 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118473951 Common - oxidoreductase MSMEG_4423 167 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118467513 Common - rhodanese-like domain protein MSMEG_5386 163 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 118469849 Common - hypothetical protein MSMEG_0383 1 None None None 118469367 Common - phytoene dehydrogenase MSMEG_5667 38 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118470616 Common - pyridine nucleotide-disulphide oxidoreductase domain protein MSMEG_6582 9 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 118468485 Common argJ bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein MSMEG_3775 167 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 118468855 Common - O-methyltransferase, putative MSMEG_5173 36 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118467401 Common - alcohol dehydrogenase B MSMEG_0217 189 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 118473032 Common - MerR-family protein transcriptional regulator MSMEG_3274 51 COG0789 SoxR, Predicted transcriptional regulators Transcription 118468343 Common - antibiotic biosynthesis monooxygenase domain protein MSMEG_6086 18 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 118469511 Common - beta-lactamase MSMEG_4337 30 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 118473075 Common - ABC transporter, ATP-binding protein MSMEG_3250 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 118467375 Common - transcriptional regulator MSMEG_1745 27 COG1309 AcrR, Transcriptional regulator Transcription 118472215 Common - hypothetical protein MSMEG_5924 1 None None None 118473243 Common - propionyl-CoA carboxylase beta chain MSMEG_4329 158 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 118467766 Common - aminopeptidase, putative MSMEG_2167 106 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 118471577 Common - hypothetical protein MSMEG_3595 4 None None None 118471291 Common - secreted protein MSMEG_4426 22 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118473690 Common - tryptophan-rich sensory protein MSMEG_1131 51 COG3476 COG3476, Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) Signal transduction mechanisms 118468051 Common - proteasome beta subunit MSMEG_3895 45 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 118472104 Common - flavin-containing monooxygenase FMO MSMEG_5022 67 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118469006 Common - GntR-family protein transcriptional regulator MSMEG_0535 65 COG1802 GntR, Transcriptional regulators Transcription 118471477 Common - Rieske [2Fe-2S] domain protein MSMEG_0299 82 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 118472008 Common - alkylated DNA repair protein MSMEG_5451 39 COG3145 AlkB, Alkylated DNA repair protein DNA replication, recombination, and repair 118470595 Common - putative transcriptional regulatory protein MSMEG_0691 24 COG2771 CsgD, DNA-binding HTH domain-containing proteins Transcription 118471312 Common - 4-carboxymuconolactone decarboxylase MSMEG_6150 85 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 118473525 Common - hypothetical protein MSMEG_6430 3 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 118471139 Common otsB trehalose-phosphatase MSMEG_6043 78 COG1877 OtsB, Trehalose-6-phosphatase Carbohydrate transport and metabolism 118473569 Common - transmembrane transport protein MSMEG_0167 72 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118467733 Common - hypothetical protein MSMEG_1581 5 COG5517 COG5517, Small subunit of phenylpropionate dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 118467505 Common - hypothetical protein MSMEG_5452 1 None None None 118467955 Common - methylenomycin A resistance protein MSMEG_3405 193 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118470201 Common - hypothetical protein MSMEG_6305 1 None None None 118473363 Common - formate dehydrogenase, gamma subunit MSMEG_0159 157 COG1905 NuoE, NADH:ubiquinone oxidoreductase 24 kD subunit Energy production and conversion 118472235 Common - IS1549, transposase MSMEG_0074 24 COG5421 COG5421, Transposase DNA replication, recombination, and repair 118469844 Common - ATPase family protein associated with various cellular activities (AAA) MSMEG_6219 176 COG0714 COG0714, MoxR-like ATPases General function prediction only 118471423 Pathogen - hypothetical protein MSMEG_4432 1 None None None 118469630 Common - RNA polymerase sigma-70 factor, family protein MSMEG_1914 172 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118468452 Common - cupin 2, conserved barrel MSMEG_2571 12 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 118470890 Common - alcohol dehydrogenase, zinc-binding MSMEG_4828 162 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118471757 Common - 3-hydroxy-3-methylglutaryl-CoA lyase MSMEG_2072 136 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 118470702 Common - LysR-family protein transcriptional regulator MSMEG_3260 36 COG0583 LysR, Transcriptional regulator Transcription 118471194 Common - hypothetical protein MSMEG_4480 1 None None None 118467466 Common - hypothetical protein MSMEG_5253 2 None None None 118470509 Common - bacterial microcompartments protein family protein MSMEG_0275 18 None None None 118467476 Common - hypothetical protein MSMEG_0047 2 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 118468618 Common cobQ cobyric acid synthase MSMEG_2588 150 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 118468262 Common - ferredoxin MSMEG_1462 71 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 118468998 Common - Bacterial extracellular solute-binding protein, family protein 3 MSMEG_0787 167 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 118469998 Common - hypothetical protein MSMEG_0492 18 COG4330 COG4330, Predicted membrane protein Function unknown 118468307 Common opcA OpcA protein MSMEG_3100 20 COG3429 COG3429, Glucose-6-P dehydrogenase subunit Carbohydrate transport and metabolism 118470291 Common - hypothetical protein MSMEG_4249 3 None None None 118467499 Common - hypothetical protein MSMEG_5390 43 COG3439 COG3439, Uncharacterized conserved protein Function unknown 118469641 Common rpsE 30S ribosomal protein S5 MSMEG_1472 243 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 118471967 Common - transcriptional regulator MSMEG_6886 133 COG1733 COG1733, Predicted transcriptional regulators Transcription 118469115 Common - 50S ribosomal protein L22 MSMEG_1441 213 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 118467469 Common gabT 4-aminobutyrate transaminase MSMEG_0581 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 118473654 Common - hypothetical protein MSMEG_2766 19 None None None 118468829 Common - putative acyl-CoA dehydrogenase MSMEG_6015 107 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473717 Common - hypothetical protein MSMEG_1065 1 None None None 118472174 Common - oxidoreductase, FAD-binding MSMEG_5037 201 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 118467492 Common - serine/threonine specific protein phosphatase MSMEG_5753 13 COG4186 COG4186, Predicted phosphoesterase or phosphohydrolase General function prediction only 118472037 Common - polyamine ABC transporter permease protein MSMEG_0659 165 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 118468091 Common - hypothetical protein MSMEG_5011 1 None None None 118473109 Common - p40 protein MSMEG_0261 21 COG2030 MaoC, Acyl dehydratase Lipid metabolism 118467622 Common - oxidoreductase, 2OG-Fe(II) oxygenase family protein MSMEG_0414 54 COG3491 PcbC, Isopenicillin N synthase and related dioxygenases General function prediction only 118470821 Common - hypothetical protein MSMEG_4744 7 None None None 118472977 Common - hypothetical protein MSMEG_1031 14 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 118469291 Common - LysR-family protein trancsriptional regulator MSMEG_1561 183 COG0583 LysR, Transcriptional regulator Transcription 118472555 Common - ppe family protein MSMEG_2737 1 None None None 118467912 Common - ribonuclease D MSMEG_2778 111 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 118467754 Common - NanT3 MSMEG_1301 9 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118471351 Common purC phosphoribosylaminoimidazole-succinocarboxamide synthase MSMEG_5841 185 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 118470356 Common - transketolase, N- subunit MSMEG_2165 218 COG3959 COG3959, Transketolase, N-terminal subunit Carbohydrate transport and metabolism 118471862 Common - methyltransferase type 11 MSMEG_5176 74 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 118472423 Common dnaK chaperone protein DnaK MSMEG_0709 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 118472806 Common - methyltransferase type 11 MSMEG_1005 176 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118469081 Common - hypothetical protein MSMEG_6796 3 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 118468968 Common - transmembrane transport protein MSMEG_0357 88 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118473125 Common - TM2 domain protein MSMEG_3223 12 COG2314 XynA, Predicted membrane protein Function unknown 118473338 Common - IS1549, transposase MSMEG_5181 24 COG5421 COG5421, Transposase DNA replication, recombination, and repair 118474001 Pathogen - hypothetical protein MSMEG_0525 1 None None None 118471926 Common - ABC transporter, ATP-binding protein MSMEG_1642 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 118469613 Common - succinate-semialdehyde dehydrogenase MSMEG_3007 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118473769 Common - CBS domain protein MSMEG_3637 216 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 118473250 Common - 5-exo-alcohol dehydrogenase MSMEG_2882 209 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 118471906 Pathogen - hypothetical protein MSMEG_1551 1 None None None 118473932 Common katA catalase KatA MSMEG_3486 127 COG0753 KatE, Catalase Inorganic ion transport and metabolism 118473408 Common folE GTP cyclohydrolase I MSMEG_6104 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 118470670 Common def peptide deformylase MSMEG_0832 206 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 118469765 Common - hypothetical protein MSMEG_4580 190 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 118472526 Common - hypothetical protein MSMEG_3969 1 None None None 118471553 Common - flavin-binding monooxygenase MSMEG_0816 74 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118469512 Common - putative TetR-family protein transcriptional regulator MSMEG_3834 23 COG1309 AcrR, Transcriptional regulator Transcription 118472310 Common - 3-hydroxybutyryl-CoA dehydratase MSMEG_4164 181 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118472480 Common - probable conserved transmembrane protein MSMEG_6676 2 None None None 118470852 Common - helix-turn-helix motif MSMEG_5243 11 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 118473468 Common - transcriptional regulator, HTH_3 family protein MSMEG_5542 51 COG1476 COG1476, Predicted transcriptional regulators Transcription 118471815 Common - alcohol dehydrogenase, zinc-containing MSMEG_5021 207 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 118471347 Pathogen - hypothetical protein MSMEG_3498 1 None None None 118473812 Common - Glycine cleavage T-protein (aminomethyl transferase) MSMEG_5796 72 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 118471427 Common - hypothetical protein MSMEG_3408 27 COG5516 COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding General function prediction only 118473259 Common - iron-sulfur cluster binding protein MSMEG_0594 94 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 118467679 Common - putative transcriptional regulator MSMEG_4449 7 COG1309 AcrR, Transcriptional regulator Transcription 118471527 Common acpP acyl carrier protein MSMEG_4326 193 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118472374 Common - hypothetical protein MSMEG_3909 11 None None None 118467565 Common hypB hydrogenase accessory protein HypB MSMEG_2271 122 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 118471261 Common soxR redox-sensitive transcriptional activator SoxR MSMEG_5450 111 COG0789 SoxR, Predicted transcriptional regulators Transcription 118468436 Common - glutamate-1-semialdehyde 2,1-aminomutase MSMEG_5970 232 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 118471889 Common - norsolorinic acid reductase MSMEG_1751 187 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 118471912 Common - hypothetical protein MSMEG_3858 18 None None None 118468573 Pathogen - hypothetical protein MSMEG_1309 1 None None None 118473170 Common - ISMsm7, transposase orfA MSMEG_1250 10 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 118471713 Common - hypothetical protein MSMEG_0626 1 None None None 118473448 Common - arabinose-proton symporter MSMEG_4182 99 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118469924 Common - amidase MSMEG_4492 217 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 118468118 Common - glyoxalase family protein MSMEG_4010 2 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 118468750 Common - SAM-dependent methyltransferase MSMEG_5310 27 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118469890 Common - 4-hydroxybenzoate transporter MSMEG_6711 164 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118471041 Common rplF 50S ribosomal protein L6 MSMEG_1470 244 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 118472939 Common - S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase MSMEG_3388 203 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 118471343 Common - carbon monoxide dehydrogenase F protein MSMEG_0747 52 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 118470630 Common - IS1096, tnpA protein MSMEG_4790 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118469236 Common - hypothetical protein MSMEG_1063 7 None None None 118473583 Pathogen - hypothetical protein MSMEG_5296 1 None None None 118468923 Common - 35 kDa protein MSMEG_2695 17 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 118471241 Common ilvD dihydroxy-acid dehydratase MSMEG_0229 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 118468116 Common - hypothetical protein MSMEG_6502 5 None None None 118472894 Common - F420-dependent glucose-6-phosphate dehydrogenase MSMEG_0777 73 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118472042 Common - SAM-dependent methyltransferase MSMEG_3430 8 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 118473650 Pathogen - hypothetical protein MSMEG_3968 1 None None None 118469783 Common - glycosyl transferase MSMEG_6484 187 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 118472143 Common tatA twin arginine-targeting protein translocase, TatA/E family protein MSMEG_3887 62 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 118473411 Common - transcriptional regulator, TetR family protein MSMEG_6604 10 COG1309 AcrR, Transcriptional regulator Transcription 118470919 Common - ABC transporter MSMEG_5009 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 118467804 Common - hypothetical protein MSMEG_0572 17 None None None 118469834 Pathogen - hypothetical protein MSMEG_0868 1 None None None 118472786 Common - enoyl-CoA hydratase MSMEG_6001 159 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118468611 Common - amino acid ABC transporter, ATP-binding protein MSMEG_6333 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 118473805 Common - monooxygenase, NtaA/SnaA/SoxA family protein MSMEG_4389 64 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118468218 Common - sugar transporter, permease protein MSMEG_4049 88 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118467844 Common - amino acid transporter MSMEG_0812 17 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118468073 Common - ABC-type transport system permease protein II MSMEG_1219 148 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 118473276 Pathogen - hypothetical protein MSMEG_1744 1 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118469398 Common - alcohol dehydrogenase MSMEG_2048 209 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 118470223 Common - major facilitator superfamily protein MSMEG_2810 63 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118472951 Common - oxidoreductase, FAD-binding MSMEG_0301 201 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 118469482 Common - carbon monoxide dehydrogenase medium chain MSMEG_5882 86 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 118467369 Common nuoL NADH dehydrogenase subunit L MSMEG_2052 207 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 118472062 Common rplP 50S ribosomal protein L16 MSMEG_1443 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 118472981 Common - bacterial extracellular solute-binding protein, family protein 5 MSMEG_4999 164 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 118474008 Common - Rieske 2Fe-2S family protein MSMEG_6410 8 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 118467877 Common - hypothetical protein MSMEG_6565 3 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 118467395 Pathogen - hypothetical protein MSMEG_6010 1 None None None 118472773 Common - transcriptional regulator, TetR family protein, putative MSMEG_1611 68 COG1309 AcrR, Transcriptional regulator Transcription 118469396 Common aroQ 3-dehydroquinate dehydratase, type II MSMEG_1922 169 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 118471842 Common - integral membrane protein MSMEG_6221 40 COG1300 SpoIIM, Uncharacterized membrane protein Function unknown 118471605 Common - integral membrane protein MSMEG_1045 29 COG2364 COG2364, Predicted membrane protein Function unknown 118468672 Common - carveol dehydrogenase MSMEG_6031 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471950 Common - integral membrane transporter MSMEG_2303 86 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 118473311 Common glgX glycogen debranching enzyme GlgX MSMEG_6507 164 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 118473382 Common - acetyl-CoA acetyltransferase MSMEG_3608 18 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118469644 Common - TobH protein MSMEG_1835 4 None None None 118470899 Common - nitrogen regulatory protein P-II MSMEG_2426 182 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 118471522 Common - hypothetical protein MSMEG_4307 82 COG3323 COG3323, Uncharacterized protein conserved in bacteria Function unknown 118473038 Common - oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_5628 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118467580 Common - phosphotransferase enzyme family protein MSMEG_0780 28 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 118469198 Common leuC isopropylmalate isomerase large subunit MSMEG_2387 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 118473710 Common - DNA-binding HTH domain containing protein, putative MSMEG_1901 74 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118470987 Pathogen - hypothetical protein MSMEG_4992 1 None None None 118470979 Common - medium-chain fatty acid-CoA ligase MSMEG_5348 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118470458 Common - putative ECF sigma factor RpoE1 MSMEG_0574 154 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118473107 Common - D-2-hydroxyglutarate dehydrogenase MSMEG_5045 200 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 118467717 Common - putative transposase MSMEG_4157 8 None None None 118470147 Common - ABC transporter permease protein MSMEG_0555 147 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 118473141 Common - ABC-type transport system permease protein I MSMEG_1220 126 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 118469705 Pathogen - hypothetical protein MSMEG_5794 1 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 118472087 Pathogen - hypothetical protein MSMEG_6335 1 None None None 118468004 Common lexA LexA repressor MSMEG_2740 173 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 118471741 Common - GAF family protein MSMEG_3941 147 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 118472637 Common - KDP operon transcriptional regulatory protein KdpE MSMEG_5396 220 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 118470170 Common - zinc-containing alcohol dehydrogenase superfamily protein MSMEG_4067 186 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118469464 Common - amino acid permease-associated region MSMEG_1508 84 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118467889 Common - hydrolase MSMEG_5210 8 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118468522 Common grpE co-chaperone GrpE MSMEG_0710 197 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 118473895 Common nuoD NADH dehydrogenase subunit D MSMEG_2060 191 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 118470366 Common pcaG protocatechuate 3,4-dioxygenase, alpha subunit MSMEG_2602 42 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 118471751 Common - transcriptional regulator, LuxR family protein MSMEG_5651 50 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118468360 Common - transcriptional regulator, TetR family protein MSMEG_2295 9 COG1309 AcrR, Transcriptional regulator Transcription 118470283 Common - sugar kinase, ribokinase family protein MSMEG_4661 174 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 118472471 Common - hypothetical protein MSMEG_6373 63 COG3246 COG3246, Uncharacterized conserved protein Function unknown 118472926 Common hybC hydrogenase-2, large subunit MSMEG_2263 92 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 118472988 Common - multimeric flavodoxin WrbA MSMEG_2666 28 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 118473809 Common - DHH family protein MSMEG_2630 58 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 118472794 Common - hypothetical protein MSMEG_0101 2 COG2353 COG2353, Uncharacterized conserved protein Function unknown 118469730 Common - transcriptional regulator, GntR family protein, putative MSMEG_2489 113 COG1802 GntR, Transcriptional regulators Transcription 118471910 Common xseA exodeoxyribonuclease VII large subunit MSMEG_5226 204 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 118473567 Common - L-carnitine dehydratase/bile acid-inducible protein F MSMEG_4046 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118470972 Common - transcriptional regulator, GntR family protein MSMEG_2794 145 COG2186 FadR, Transcriptional regulators Transcription 118468925 Common - hypothetical protein MSMEG_3682 16 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 118470189 Common - hypothetical protein MSMEG_6518 1 None None None 118473241 Common - AMP-binding enzyme MSMEG_3468 215 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118472607 Common - integral membrane protein MSMEG_3650 25 COG3856 Sbp, Uncharacterized conserved protein (small basic protein) Function unknown 118467670 Common - hypothetical protein MSMEG_6739 1 None None None 118473760 Common - aerobic C4-dicarboxylate transport protein MSMEG_5302 150 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 118469412 Common - transcriptional regulator MSMEG_3961 34 COG1309 AcrR, Transcriptional regulator Transcription 118473491 Common - hypothetical protein MSMEG_1240 6 None None None 118470130 Common - putative acyl-CoA dehydrogenase MSMEG_6562 143 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473422 Common - hypothetical protein MSMEG_4743 26 COG4312 COG4312, Uncharacterized protein conserved in bacteria Function unknown 118471065 Common araB ribulokinase MSMEG_1713 104 COG1069 AraB, Ribulose kinase Energy production and conversion 118469262 Common hypD hydrogenase expression/formation protein HypD MSMEG_2275 108 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 118472129 Common - cytochrome bd ubiquinol oxidase, subunit I MSMEG_5605 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 118471812 Common - H-N-H endonuclease F-TflIV MSMEG_5876 2 None None None 118473725 Common - ABC transporter, ATPase subunit MSMEG_3108 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 118470690 Common - two component response transcriptional regulatory protein prra MSMEG_0244 226 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 118468329 Common mtaP 5'-methylthioadenosine phosphorylase MSMEG_0990 138 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 118470051 Common - hypothetical protein MSMEG_3552 6 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 118468932 Common - Mg-chelatase subunits D/I family protein, ComM subfamily protein MSMEG_2509 189 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 118467485 Common - para-nitrobenzyl esterase MSMEG_3667 86 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 118473536 Common - ABC transporter, ATP-binding subunit MSMEG_3119 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 118470319 Common - malonyl CoA decarboxylase MSMEG_2128 43 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 118473313 Common - cell envelope-related function transcriptional attenuator common domain MSMEG_0107 43 COG1316 LytR, Transcriptional regulator Transcription 118471699 Common tpiA triosephosphate isomerase MSMEG_3086 217 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 118473190 Common rplC 50S ribosomal protein L3 MSMEG_1436 225 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 118468103 Common hisD histidinol dehydrogenase MSMEG_2012 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 118471692 Common - alcohol dehydrogenase, zinc-binding MSMEG_5778 100 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118472323 Common - ATPase, AAA family protein MSMEG_0059 94 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 118471645 Common - 3-mercaptopyruvate sulfurtransferase MSMEG_3238 125 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 118471067 Common - MmpL6 protein MSMEG_0185 47 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118468993 Common - serine/threonine-protein kinase PknE MSMEG_5513 152 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 118472058 Common - virulence factor Mce family protein MSMEG_1144 49 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118471772 Common recC exodeoxyribonuclease V, gamma subunit MSMEG_1328 64 COG1330 RecC, Exonuclease V gamma subunit DNA replication, recombination, and repair 118468864 Common - glycine/D-amino acid oxidase MSMEG_6471 98 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 118468259 Common - PTS system, Fru family protein, IIABC components MSMEG_0085 130 COG1299 FruA, Phosphotransferase system, fructose-specific IIC component Carbohydrate transport and metabolism 118472416 Common smc chromosome segregation protein SMC MSMEG_2423 181 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 118471382 Common - monooxygenase MSMEG_3583 80 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118473189 Common - dehydrogenase MSMEG_4433 160 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 118469478 Common - hypothetical protein MSMEG_2066 4 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 118472984 Common - dopamine receptor D4 MSMEG_3522 1 None None None 118468646 Pathogen - hypothetical protein MSMEG_3716 1 None None None 118471949 Common - acyl-CoA dehydrogenase MSMEG_4805 150 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118470815 Common - putative DNA-binding protein MSMEG_0622 3 None None None 118471166 Common - hypothetical protein MSMEG_4692 6 None None None 118471301 Common - hypothetical protein MSMEG_1980 68 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118469427 Common - hypothetical protein MSMEG_0045 4 None None None 118471403 Common - AsnC-family protein transcriptional regulator MSMEG_0838 52 COG1522 Lrp, Transcriptional regulators Transcription 118472756 Common - hypothetical protein MSMEG_2560 17 None None None 118467786 Pathogen - hypothetical protein MSMEG_5299 1 None None None 118469646 Common - ribonuclease activity regulator protein RraA MSMEG_6439 100 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 118469958 Common - hypothetical protein MSMEG_0605 13 COG1647 COG1647, Esterase/lipase General function prediction only 118467420 Common - caax amino protease family protein MSMEG_5188 7 None None None 118473304 Common typA GTP-binding protein TypA/BipA MSMEG_5132 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 118470058 Common - ABC transporter, nucleotide binding/ATPase protein, sn-Glycerol-3-phosphate MSMEG_0518 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 118473384 Common - transporter, major facilitator family protein MSMEG_4104 34 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118471963 Pathogen - hypothetical protein MSMEG_1750 1 None None None 118471515 Common - putative septation inhibitor protein MSMEG_0026 13 None None None 118471323 Common - hypothetical protein MSMEG_0820 5 None None None 118468511 Common - polyprenyl synthetase MSMEG_4240 241 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 118470795 Common rplT 50S ribosomal protein L20 MSMEG_3791 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 118469390 Common - trans-aconitate 2-methyltransferase MSMEG_0629 72 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 118470889 Common - MmpS3 protein MSMEG_1932 1 COG5373 COG5373, Predicted membrane protein Function unknown 118470742 Common - hypothetical protein MSMEG_0007 16 COG0392 COG0392, Predicted integral membrane protein Function unknown 118472683 Common - peptidase, M16 family protein MSMEG_2657 184 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 118471122 Common - oxidoreductase, zinc-binding dehydrogenase family protein MSMEG_2033 173 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118472366 Common - 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase MSMEG_4867 166 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118470955 Common - antigen 85-C MSMEG_6583 13 COG0627 COG0627, Predicted esterase General function prediction only 118468161 Pathogen - hypothetical protein MSMEG_2265 1 None None None 118469961 Pathogen - hypothetical protein MSMEG_4409 1 None None None 118470959 Common - virulence factor mce family protein MSMEG_4786 9 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118471077 Common - hypothetical oxidoreductase YjgI MSMEG_4351 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470411 Common pstA phosphate ABC transporter, permease protein PstA MSMEG_5780 231 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 118469817 Common - D-xylose transport ATP-binding protein XylG MSMEG_1705 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 118473366 Common ftsY signal recognition particle-docking protein FtsY MSMEG_2424 246 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 118469360 Common - oxidoreductase, zinc-binding dehydrogenase family protein MSMEG_3603 199 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 118472246 Common - type I antifreeze protein MSMEG_5479 22 COG2331 COG2331, Uncharacterized protein conserved in bacteria Function unknown 118471459 Common cadA cadmium-translocating P-type ATPase MSMEG_5403 231 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 118472718 Common - hypothetical protein MSMEG_5932 10 None None None 118471971 Common - IS1096, tnpA protein MSMEG_6697 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118470398 Common - hypothetical protein MSMEG_0368 5 None None None 118471420 Common arcA arginine deiminase MSMEG_5448 52 COG2235 ArcA, Arginine deiminase Amino acid transport and metabolism 118471204 Common rnhA RNase H MSMEG_5562 175 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 118468850 Common - sulfate-binding protein MSMEG_4533 98 COG1613 Sbp, ABC-type sulfate transport system, periplasmic component Inorganic ion transport and metabolism 118467710 Common - 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_0715 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118472630 Common - RNA polymerase sigma-70 factor, putative MSMEG_6682 2 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118468171 Common purN phosphoribosylglycinamide formyltransferase MSMEG_5516 220 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 118467994 Common - hypothetical protein MSMEG_1810 1 None None None 118468826 Common - hypothetical protein MSMEG_2749 7 None None None 118467405 Common xerD site-specific tyrosine recombinase XerD MSMEG_3744 226 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 118468576 Common - putative transcription regulator MSMEG_6864 57 COG1414 IclR, Transcriptional regulator Transcription 118471776 Common - hypothetical protein MSMEG_2443 17 None None None 118467452 Common - putative acyl-CoA dehydrogenase MSMEG_4826 158 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118470304 Common - alcohol dehydrogenase MSMEG_3464 208 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 118472422 Common - acyl-CoA dehydrogenase domain protein MSMEG_2190 133 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118467708 Common - Fe-dependent alcohol dehydrogenase MSMEG_3006 162 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 118472626 Common - putative monooxygenase MSMEG_5810 69 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118470442 Common - dehydrogenase MSMEG_5400 53 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118468495 Common - cytochrome P450-terp MSMEG_1431 77 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118471623 Common - transcriptional regulator, LuxR family protein MSMEG_0330 131 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118468567 Common - hypothetical protein MSMEG_0041 3 None None None 118472319 Common - haloacid dehalogenase, type II MSMEG_4059 67 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 118469686 Common moaC molybdenum cofactor biosynthesis protein C MSMEG_5703 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 118471651 Common - transposase IstA protein, putative MSMEG_2151 51 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 118470838 Common - [NiFe] hydrogenase, beta subunit, putative MSMEG_3931 31 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 118469698 Common - amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family protein MSMEG_6909 175 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 118468462 Common - sugar ABC transporter ATP-binding protein MSMEG_4656 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 118468282 Pathogen - hypothetical protein MSMEG_6650 1 None None None 118471444 Common - hypothetical protein MSMEG_0837 1 None None None 118470944 Common - ABC-type amino acid transport system, permease component MSMEG_3236 173 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 118470197 Common - hypothetical protein MSMEG_5071 6 None None None 118470924 Pathogen - hypothetical protein MSMEG_0440 1 None None None 118471662 Pathogen - hypothetical protein MSMEG_2577 1 None None None 118470862 Common - acetyl-CoA acetyltransferases MSMEG_3012 187 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118472632 Common - transcriptional regulator, IclR family protein MSMEG_2483 121 COG1414 IclR, Transcriptional regulator Transcription 118471484 Common - putative cytochrome P450 126 MSMEG_4619 64 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118472225 Common - pyruvate dehydrogenase E1 component subunit beta MSMEG_4711 213 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 118469677 Common - N-acetylmuramoyl-L-alanine amidase MSMEG_6281 40 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 118469892 Common hypA hydrogenase nickel insertion protein HypA MSMEG_2272 8 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 118467764 Common pcaD 3-oxoadipate enol-lactonase MSMEG_1897 135 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118471819 Common - transcription regulator FurA MSMEG_6383 68 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 118467778 Common - hypothetical protein MSMEG_4730 3 None None None 118473676 Common panD aspartate 1-decarboxylase MSMEG_0021 130 COG0853 PanD, Aspartate 1-decarboxylase Coenzyme metabolism 118468019 Common - IS1137, transposase orfA MSMEG_0724 44 None None None 118472004 Common - epoxide hydrolase MSMEG_3407 43 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118467858 Common pheT phenylalanyl-tRNA synthetase subunit beta MSMEG_3777 222 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 118473387 Common - hypothetical protein MSMEG_6793 6 None None None 118473699 Common - acyl-CoA synthetase MSMEG_2131 208 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118468405 Common - hypothetical protein MSMEG_3467 7 COG3688 COG3688, Predicted RNA-binding protein containing a PIN domain General function prediction only 118469385 Common - hypothetical protein MSMEG_6923 11 None None None 118470613 Common - hypothetical protein MSMEG_0971 120 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 118469915 Common rpsB 30S ribosomal protein S2 MSMEG_2519 228 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 118468552 Common - transcriptional regulator MSMEG_0878 83 COG1309 AcrR, Transcriptional regulator Transcription 118470712 Common - salicylate esterase MSMEG_1797 32 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118472604 Common - hypothetical protein MSMEG_3324 1 None None None 118468953 Common - amino acid permease family protein, putative MSMEG_4377 168 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118467892 Pathogen - hypothetical protein MSMEG_4506 1 None None None 118468974 Common - major facilitator superfamily protein MSMEG_1477 132 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118473916 Common - acetyltransferase MSMEG_2581 14 COG3393 COG3393, Predicted acetyltransferase General function prediction only 118469549 Common - hypothetical protein MSMEG_1936 9 None None None 118472012 Common - hydrolase, alpha/beta fold family protein MSMEG_5209 156 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118471799 Common - ABC1 family protein MSMEG_1353 184 COG0661 AarF, Predicted unusual protein kinase General function prediction only 118469576 Common - MarR-family protein transcriptional regulator MSMEG_6508 54 COG1846 MarR, Transcriptional regulators Transcription 118472336 Common - cobalt transport protein ATP-binding subunit MSMEG_2610 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 118467542 Common nusG transcription antitermination protein NusG MSMEG_1345 215 COG0250 NusG, Transcription antiterminator Transcription 118474027 Common - L-carnitine dehydratase/bile acid-inducible protein F MSMEG_1992 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118469682 Common - cytochrome bd-I oxidase subunit II MSMEG_5606 144 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 118469694 Common - hypothetical protein MSMEG_3081 44 COG1481 COG1481, Uncharacterized protein conserved in bacteria Function unknown 118472161 Common - putative inner membrane protein translocase component YidC MSMEG_6942 208 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 118468346 Common - mycocerosic acid synthase MSMEG_6767 210 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118467854 Pathogen - mesocentin MSMEG_6358 1 COG5373 COG5373, Predicted membrane protein Function unknown 118470062 Common - 6-phosphogluconate dehydrogenase, NAD-binding MSMEG_4816 171 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 118470732 Common - hypothetical protein MSMEG_4508 37 COG3251 COG3251, Uncharacterized protein conserved in bacteria Function unknown 118470900 Common - periplasmic binding protein MSMEG_4560 92 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 118472979 Common - ethyl tert-butyl ether degradation EthD MSMEG_2953 14 None None None 118467899 Common - transcriptional regulator, LacI family protein MSMEG_0491 127 COG1609 PurR, Transcriptional regulators Transcription 118472022 Common hemC porphobilinogen deaminase MSMEG_0953 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 118471821 Common - putative acyl-CoA dehydrogenase MSMEG_2878 31 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118471785 Common - hypothetical protein MSMEG_3681 1 None None None 118472629 Common frr ribosome recycling factor MSMEG_2541 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 118471567 Common - amidohydrolase family protein MSMEG_4808 20 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118472114 Common - hypothetical protein MSMEG_2458 57 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 118469662 Common speB agmatinase MSMEG_4374 159 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 118472780 Pathogen - hypothetical protein MSMEG_0364 1 None None None 118473802 Common purS phosphoribosylformylglycinamidine synthase subunit PurS MSMEG_5832 92 COG1828 PurS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component Nucleotide transport and metabolism 118472389 Common - anti-sigma factor antagonist MSMEG_6541 8 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 118468224 Pathogen - putative lipoprotein MSMEG_0472 2 None None None 118472019 Common - hypothetical protein MSMEG_6233 44 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 118469109 Common - nucleoside-diphosphate-sugar epimerase MSMEG_6474 153 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118471395 Pathogen - hypothetical protein MSMEG_5377 1 None None None 118470641 Common - cytosine/purine/uracil/thiamine/allantoin permease family protein MSMEG_5653 41 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 118468214 Common - transcriptional regulator, TetR family protein MSMEG_5854 3 COG1309 AcrR, Transcriptional regulator Transcription 118470222 Common - hypothetical protein MSMEG_0552 41 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 118472929 Common - shikimate 5-dehydrogenase MSMEG_6704 159 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 118469790 Common - luciferase MSMEG_5626 89 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118468137 Common - phytanoyl-CoA dioxygenase MSMEG_4649 13 COG5285 COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin Secondary metabolites biosynthesis, transport, and catabolism 118472836 Common - thioesterase family protein MSMEG_3571 10 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 118470248 Common - glutamate binding protein MSMEG_2727 175 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 118467831 Common - putative ABC transporter ATP-binding protein MSMEG_4700 246 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 118473296 Common hisB imidazoleglycerol-phosphate dehydratase MSMEG_3207 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 118472661 Common - hypothetical protein MSMEG_4814 88 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118467791 Common - linalool 8-monooxygenase MSMEG_3551 70 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118468685 Common - lipoprotein MSMEG_6220 35 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 118473004 Common - zinc-binding alcohol dehydrogenase MSMEG_4032 128 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118468373 Common - cation ABC transporter, periplasmic cation-binding protein, putative MSMEG_6047 73 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 118472448 Common ureC urease subunit alpha MSMEG_1094 96 COG0804 UreC, Urea amidohydrolase (urease) alpha subunit Amino acid transport and metabolism 118473220 Common - transcriptional regulator MSMEG_1596 29 COG1309 AcrR, Transcriptional regulator Transcription 118468593 Common - membrane transport protein MSMEG_0467 78 COG1279 COG1279, Lysine efflux permease General function prediction only 118467373 Common - DoxD family protein/pyridine nucleotide-disulfide oxidoreductase MSMEG_3457 148 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 118472658 Common - ferric uptake regulation protein MSMEG_3460 120 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 118468395 Common - ISMsm5, transposase MSMEG_5891 52 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 118467658 Common - IS1096, tnpA protein MSMEG_6161 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118470826 Common moxR ATPase, MoxR family protein MSMEG_6612 172 COG0714 COG0714, MoxR-like ATPases General function prediction only 118473785 Pathogen - hypothetical protein MSMEG_3068 1 None None None 118468369 Common - gamma-glutamylisopropylamide synthetase MSMEG_2595 224 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 118472122 Common - 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase MSMEG_6037 172 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118473143 Common - D-beta-hydroxybutyrate dehydrogenase MSMEG_4358 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118467943 Common - ribose 5-phosphate isomerase MSMEG_3272 123 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 118469532 Common sufC FeS assembly ATPase SufC MSMEG_3124 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 118469927 Common - hypothetical protein MSMEG_5311 1 None None None 118471483 Common - epoxide hydrolase MSMEG_6719 146 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118472307 Common - hypothetical protein MSMEG_1077 6 None None None 118467775 Common - hypothetical protein MSMEG_0973 22 COG1333 ResB, ResB protein required for cytochrome c biosynthesis Posttranslational modification, protein turnover, chaperones 118471119 Common - drug transporter MSMEG_3563 227 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118473475 Common - hypothetical protein MSMEG_5517 5 None None None 118473705 Common - hypothetical protein MSMEG_6159 181 COG1278 CspC, Cold shock proteins Transcription 118468848 Common - ISMsm1, transposase orfA MSMEG_2819 34 None None None 118471675 Common - hypothetical protein MSMEG_6446 1 None None None 118467747 Common - hypothetical protein MSMEG_0987 1 None None None 118471834 Common cheR CheR methyltransferase, SAM binding domain protein MSMEG_5553 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 118473233 Common rpmD ribosomal protein L30 MSMEG_1473 107 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 118473214 Common - transcriptional regulator, LuxR family protein MSMEG_0331 121 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118469276 Common - cytochrome P450 superfamily protein MSMEG_2563 79 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118470013 Common - ABC transporter, quaternary amine uptake transporter (QAT) family protein, substrate-binding protein MSMEG_6334 78 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 118472560 Common - glyoxalase family protein MSMEG_6625 1 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 118473544 Common - YceI like family protein MSMEG_2065 65 COG2353 COG2353, Uncharacterized conserved protein Function unknown 118471669 Common - hypothetical protein MSMEG_6395 2 None None None 118473929 Common - hypothetical protein MSMEG_0933 160 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 118468661 Common - hypothetical protein MSMEG_2249 31 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118468905 Common - 6-hydroxy-D-nicotine oxidase MSMEG_1746 106 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 118473231 Common - salicylate synthase MbtI MSMEG_4524 221 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 118468676 Common - enoyl-CoA hydratase MSMEG_1048 182 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118468087 Common - AsnC-family protein transcriptional regulator MSMEG_2472 12 COG1522 Lrp, Transcriptional regulators Transcription 118468374 Common - transcriptional regulator, GntR family protein MSMEG_2209 133 COG1802 GntR, Transcriptional regulators Transcription 118467360 Common - major facilitator superfamily protein permease MSMEG_4767 94 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 118473020 Common - putative integral membrane protein MSMEG_5160 5 None None None 118467570 Common - hypothetical protein MSMEG_2707 3 None None None 118468074 Common - hypothetical protein MSMEG_5686 4 None None None 118469885 Common - hypothetical protein MSMEG_0025 5 None None None 118467642 Common gabD2 succinic semialdehyde dehydrogenase MSMEG_5912 222 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118469803 Pathogen - hypothetical protein MSMEG_1101 1 None None None 118469024 Common - carnitinyl-CoA dehydratase MSMEG_1155 185 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118469826 Common - hypothetical protein MSMEG_4199 120 COG1881 COG1881, Phospholipid-binding protein General function prediction only 118471634 Common - hypothetical protein MSMEG_5602 4 COG3339 COG3339, Uncharacterized conserved protein Function unknown 118471704 Common katG catalase/peroxidase HPI MSMEG_3461 98 COG0376 KatG, Catalase (peroxidase I) Inorganic ion transport and metabolism 118468181 Common - 1-acylglycerol-3-phosphate O-acyltransferase MSMEG_4248 182 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 118468411 Common - stress responsive A/B Barrel Domain superfamily protein MSMEG_2010 6 None None None 118467651 Common - IS1096, tnpA protein MSMEG_3697 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118469443 Common - ABC transporter, ATP-binding protein, NodI family protein MSMEG_6766 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 118469347 Common - helix-turn-helix motif MSMEG_5136 9 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 118467367 Common - NAD dependent epimerase/dehydratase family protein MSMEG_0946 123 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118471591 Common - hypothetical protein MSMEG_4518 5 None None None 118469420 Common rpmH 50S ribosomal protein L34 MSMEG_6946 188 None None None 118468622 Common - AP endonuclease, family protein 2 MSMEG_6790 12 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 118468069 Common - hypothetical protein MSMEG_6722 7 COG3662 COG3662, Uncharacterized protein conserved in bacteria Function unknown 118468031 Common - hydrolase MSMEG_2669 103 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 118468791 Common - hydrolase, alpha/beta fold family protein MSMEG_3287 123 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118470178 Common - 30S ribosomal protein S17 MSMEG_1445 224 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 118473174 Common - probable conserved mce associated membrane protein MSMEG_0140 2 None None None 118468928 Common - regulatory protein, TetR MSMEG_5177 70 COG1309 AcrR, Transcriptional regulator Transcription 118473266 Pathogen - hypothetical protein MSMEG_2144 2 None None None 118472916 Common - acyl-CoA dehydrogenase, C- domain protein MSMEG_2993 62 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472398 Common - hypothetical protein MSMEG_6182 14 COG5393 COG5393, Predicted membrane protein Function unknown 118471929 Common - acyl-CoA dehydrogenase domain protein MSMEG_6511 143 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118470807 Common guaA bifunctional GMP synthase/glutamine amidotransferase protein MSMEG_1610 240 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 118473442 Common - morphine 6-dehydrogenase MSMEG_2407 180 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 118471214 Common - hypothetical protein MSMEG_5694 5 None None None 118473098 Common - cupin domain protein MSMEG_5761 5 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 118472970 Common - hypothetical protein MSMEG_1053 10 COG1520 COG1520, FOG: WD40-like repeat Function unknown 118473045 Common - probable acyltransferase MSMEG_6230 13 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 118473010 Common - O-sialoglycoprotein endopeptidase MSMEG_1580 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 118470333 Common - caib/baif family protein MSMEG_6642 113 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118468432 Common - methylated-DNA--protein-cysteine methyltransferase MSMEG_4316 217 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 118472974 Common - NAD-dependent deacetylase 1 MSMEG_4620 151 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 118472073 Common rnpA ribonuclease P protein component MSMEG_6945 21 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 118473254 Common - hypothetical protein MSMEG_0580 16 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 118471730 Common - acyl-CoA synthetase MSMEG_5295 225 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118471586 Common - protein of unknown function DUF6, transmembrane, putative MSMEG_3416 14 COG4975 GlcU, Putative glucose uptake permease Carbohydrate transport and metabolism 118472410 Common - hypothetical protein MSMEG_4922 14 None None None 118472409 Common - beta-lactamase MSMEG_3378 139 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 118472157 Common - LytR/CpsA/Psr family protein MSMEG_5775 61 COG1316 LytR, Transcriptional regulator Transcription 118471360 Common - DNA-binding response regulator, putative MSMEG_5159 205 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 118471682 Common - enoyl-CoA hydratase/isomerase family protein MSMEG_2218 167 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118467669 Common - transcriptional regulator, TetR family protein MSMEG_1430 3 COG1309 AcrR, Transcriptional regulator Transcription 118469182 Common - allantoicase MSMEG_1294 19 COG3195 COG3195, Uncharacterized protein conserved in bacteria Function unknown 118470789 Pathogen - hypothetical protein MSMEG_6706 1 None None None 118469745 Common - hypothetical protein MSMEG_1067 12 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 118470033 Common - putative transcriptional regulatory protein MSMEG_1175 83 COG0640 ArsR, Predicted transcriptional regulators Transcription 118471924 Common - hypothetical protein MSMEG_4151 4 COG1141 Fer, Ferredoxin Energy production and conversion 118471658 Common gidB methyltransferase GidB MSMEG_6940 202 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 118473982 Common - PAP2 superfamily protein MSMEG_1385 4 None None None 118471254 Common - porin MSMEG_0520 2 None None None 118470024 Common - hypothetical protein MSMEG_0044 4 None None None 118472292 Common - secreted protein MSMEG_5700 12 COG5373 COG5373, Predicted membrane protein Function unknown 118470499 Common - acetate operon repressor MSMEG_5475 120 COG1414 IclR, Transcriptional regulator Transcription 118473867 Pathogen - hypothetical protein MSMEG_1856 1 None None None 118474045 Common - short chain oxidoreductase MSMEG_2895 222 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118467961 Common - transposase MSMEG_6023 14 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 118472096 Common - hypothetical protein MSMEG_3686 1 None None None 118473792 Common - oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_3805 235 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118468713 Common - L-lysine aminotransferase MSMEG_1764 236 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 118467860 Common - ABC nitrate/sulfonate/bicarbonate family protein transporter, inner membrane subunit MSMEG_2501 188 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 118472209 Common - putative aliphatic sulfonates transport ATP-binding protein SsuB MSMEG_3853 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 118468388 Common - hypothetical protein MSMEG_0927 10 None None None 118469772 Common - phosphoadenosine phosphosulfate reductase MSMEG_1245 32 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 118472990 Common - hydrolase MSMEG_1078 51 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 118470423 Common - transcriptional regulator, TetR family protein MSMEG_5424 141 COG1309 AcrR, Transcriptional regulator Transcription 118473888 Common - amidohydrolase MSMEG_0297 89 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 118468479 Common - integral membrane transport protein MSMEG_0896 135 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118473662 Common - inositol monophosphatase family protein MSMEG_4190 129 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 118473079 Common - oxidoreductase, FAD-linked MSMEG_0451 1 None None None 118469009 Common - [2Fe-2S] binding domain protein MSMEG_0745 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 118473017 Common - hypothetical protein MSMEG_5689 3 None None None 118472035 Common - lactate 2-monooxygenase MSMEG_3962 122 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 118470776 Common rnc ribonuclease III MSMEG_2418 216 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 118471614 Common - hypothetical protein MSMEG_3261 16 None None None 118474051 Common - DNA gyrase subunit A MSMEG_0456 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 118468783 Common - acyl-CoA dehydrogenase, middle domain protein MSMEG_2234 137 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118468937 Common - hypothetical protein MSMEG_3192 7 None None None 118471145 Common - ATPase MSMEG_5044 58 COG2251 COG2251, Predicted nuclease (RecB family) General function prediction only 118470105 Common - ferric cations import ATP-binding protein FbpC MSMEG_3633 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 118469913 Common - universal stress protein family protein MSMEG_3939 12 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 118473842 Common - hypothetical protein MSMEG_3733 30 None None None 118472275 Common - hypothetical protein MSMEG_0298 4 None None None 118470001 Common - hypothetical protein MSMEG_5089 2 None None None 118470575 Common - glyoxalase family protein MSMEG_3882 41 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 118471574 Common pgi glucose-6-phosphate isomerase MSMEG_5541 201 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 118472764 Common amt ammonium transporter MSMEG_6259 201 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 118472506 Common - protein of unknown function DUF58, putative MSMEG_6610 88 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 118467435 Common - oxidoreductase, 2OG-Fe(II) oxygenase family protein MSMEG_4008 55 COG3491 PcbC, Isopenicillin N synthase and related dioxygenases General function prediction only 118470934 Common - glutaryl-CoA dehydrogenase MSMEG_5267 159 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118468744 Common - antigen 85-A MSMEG_6398 7 COG0627 COG0627, Predicted esterase General function prediction only 118472726 Common - transcriptional regulator, TetR family protein MSMEG_3410 43 COG1309 AcrR, Transcriptional regulator Transcription 118472436 Common - radical SAM domain protein MSMEG_5410 55 COG1964 COG1964, Predicted Fe-S oxidoreductases General function prediction only 118473605 Common - hypothetical protein MSMEG_3781 19 COG3662 COG3662, Uncharacterized protein conserved in bacteria Function unknown 118472150 Common - dTDP-glucose 4,6-dehydratase MSMEG_4136 23 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118470008 Common - hypothetical protein MSMEG_3614 1 None None None 118473624 Common - sugar transporter family protein MSMEG_2380 19 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118468400 Common - hypothetical protein MSMEG_3937 3 None None None 118473297 Pathogen - hypothetical protein MSMEG_4404 1 None None None 118471735 Common - aldehyde dehydrogenase (NAD) family protein MSMEG_4799 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118470950 Pathogen - hypothetical protein MSMEG_2221 1 None None None 118470121 Common - IS1096, tnpR protein MSMEG_6698 44 None None None 118469211 Common - hypothetical protein MSMEG_1884 10 None None None 118472952 Pathogen - hypothetical protein MSMEG_0396 1 None None None 118468354 Common - cyclopropane-fatty-acyl-phospholipid synthase 1 MSMEG_1350 126 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 118468323 Common - cytidine and deoxycytidylate deaminase family protein MSMEG_6327 202 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 118472518 Common - NAD-dependent epimerase/dehydratase MSMEG_6843 158 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118473379 Common - polyprenol-monophosphomannose synthase Ppm1 MSMEG_3860 145 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 118467740 Common - SAM-dependent methyltransferase MSMEG_2632 44 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118469493 Pathogen - hypothetical protein MSMEG_3565 1 None None None 118473153 Common - hypothetical protein MSMEG_1008 7 None None None 118469245 Pathogen - hypothetical protein MSMEG_5384 1 None None None 118470438 Common - hypothetical protein MSMEG_2626 14 COG2740 COG2740, Predicted nucleic-acid-binding protein implicated in transcription termination Transcription 118468267 Common - hypothetical protein MSMEG_0046 6 None None None 118468472 Common - acyl carrier protein MSMEG_3311 5 None None None 118471130 Common - ABC transporter ATP-binding protein MSMEG_5571 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 118473131 Common - sigma factor MSMEG_1970 152 COG3284 AcoR, Transcriptional activator of acetoin/glycerol metabolism Secondary metabolites biosynthesis, transport, and catabolism / Transcription 118472593 Common - 3-alpha-hydroxysteroid dehydrogenase MSMEG_4862 224 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471331 Common - hypothetical protein MSMEG_4363 10 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 118468796 Common - acyl-CoA synthetase MSMEG_5114 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118470118 Common - 3-oxoacyl-(acyl-carrier-protein) reductase, putative MSMEG_6538 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118469224 Common cysNC bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein MSMEG_4978 249 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 118470348 Common dnaJ chaperone protein DnaJ MSMEG_0711 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 118469703 Common - GntR-family protein transcriptional regulator MSMEG_2599 135 COG2186 FadR, Transcriptional regulators Transcription 118472821 Common - RNA polymerase sigma-70 factor, TIGR02957 family protein MSMEG_5444 47 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118470573 Common - hypothetical protein MSMEG_1734 21 None None None 118473427 Common - FAD dependent oxidoreductase MSMEG_3987 31 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 118473595 Common - transcriptional regulator, TetR family protein MSMEG_6009 141 COG1309 AcrR, Transcriptional regulator Transcription 118469541 Common - DNA polymerase I MSMEG_3839 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 118467635 Common - hypothetical protein MSMEG_3837 14 COG2966 COG2966, Uncharacterized conserved protein Function unknown 118472051 Common - phosphoglucomutase/phosphomannomutase MSMEG_1695 183 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 118467619 Common - membrane protein MSMEG_1944 18 COG4270 COG4270, Predicted membrane protein Function unknown 118469723 Pathogen - hypothetical protein MSMEG_2741 1 None None None 118468193 Common tsf elongation factor Ts MSMEG_2520 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 118473597 Common - hypothetical protein MSMEG_0078 1 None None None 118470506 Pathogen - hypothetical protein MSMEG_1260 1 None None None 118469073 Common rimM 16S rRNA-processing protein MSMEG_2437 186 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 118473074 Common - transcriptional regulatory protein MSMEG_2849 133 COG1733 COG1733, Predicted transcriptional regulators Transcription 118473434 Common - hypothetical protein MSMEG_3459 28 COG2966 COG2966, Uncharacterized conserved protein Function unknown 118470555 Common - cytochrome P450 MSMEG_4153 68 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118472576 Common - hypothetical protein MSMEG_6921 119 COG1678 COG1678, Putative transcriptional regulator Transcription 118471598 Common - amino acid-binding ACT MSMEG_2363 9 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 118470518 Common msrA methionine sulfoxide reductase A MSMEG_4417 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 118471284 Common - cyclase/dehydrase MSMEG_5736 8 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 118467601 Common - hypothetical protein MSMEG_1513 11 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118473438 Common - metallo-beta-lactamase superfamily protein MSMEG_0775 91 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 118472200 Common - transcriptional regulator, ArsR family protein MSMEG_5405 61 COG0640 ArsR, Predicted transcriptional regulators Transcription 118468449 Common - glycerol-3-phosphate dehydrogenase 1 MSMEG_4332 148 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 118471868 Common - transcriptional regulatory protein MSMEG_6605 35 COG1695 COG1695, Predicted transcriptional regulators Transcription 118470968 Common - short chain dehydrogenase MSMEG_0283 231 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471795 Common - transcriptional regulator, TetR family protein MSMEG_3193 38 COG1309 AcrR, Transcriptional regulator Transcription 118471057 Common - amidohydrolase 2 MSMEG_4837 21 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118471537 Common - hypothetical protein MSMEG_1332 2 None None None 118473683 Common - molybdopterin oxidoreductase MSMEG_3521 177 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 118467760 Common - ISMsm4, transposase MSMEG_5398 43 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118468334 Pathogen - NAD-dependent epimerase/dehydratase MSMEG_3813 1 None None None 118468429 Common narH nitrate reductase, beta subunit MSMEG_5139 146 COG1140 NarY, Nitrate reductase beta subunit Energy production and conversion 118474016 Common - oxidoreductase, Gfo/Idh/MocA family protein MSMEG_2637 142 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 118468064 Common - hypothetical protein MSMEG_3658 13 None None None 118471465 Common - aldehyde dehydrogenase MSMEG_2881 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118471628 Common - beta-lactamase MSMEG_1586 140 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 118472958 Common - glyoxalase family protein MSMEG_1417 35 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 118469146 Common - beta-glucosidase A MSMEG_5142 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 118470461 Pathogen - hypothetical protein MSMEG_1879 1 None None None 118467633 Common - nucleoside-diphosphate-sugar epimerase MSMEG_5799 126 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118468638 Common - type III restriction enzyme, res subunit MSMEG_1238 113 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 118473670 Common - hypothetical protein MSMEG_6054 100 COG1540 COG1540, Uncharacterized proteins, homologs of lactam utilization protein B General function prediction only 118468154 Pathogen - hypothetical protein MSMEG_5740 1 None None None 118470832 Common - hypothetical protein MSMEG_0593 66 COG1556 COG1556, Uncharacterized conserved protein Function unknown 118468991 Common - CAIB/BAIF family protein MSMEG_2073 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118467522 Common - probable conserved transmembrane protein MSMEG_0245 11 None None None 118472182 Common ilvC ketol-acid reductoisomerase MSMEG_2374 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 118470280 Common - short-chain dehydrogenase/reductase SDR MSMEG_1563 213 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118467991 Common - 4-hydroxybutyrate coenzyme A transferase MSMEG_6310 101 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 118469534 Common - hypothetical protein MSMEG_2157 2 COG4278 COG4278, Uncharacterized conserved protein Function unknown 118473391 Common - hypothetical protein MSMEG_3014 8 COG3801 COG3801, Uncharacterized protein conserved in bacteria Function unknown 118471689 Common - oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_6753 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471808 Common - hypothetical protein MSMEG_4582 40 COG3552 CoxE, Protein containing von Willebrand factor type A (vWA) domain General function prediction only 118469092 Common - 5-oxovalerate dehydrogenase MSMEG_1158 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118469454 Common lipP carboxylesterase, putative MSMEG_4680 84 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 118473127 Common - glucose-methanol-choline oxidoreductase MSMEG_1428 85 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 118470270 Common - MspD protein MSMEG_6057 2 None None None 118470748 Common - Low molecular weight protein antigen 6 MSMEG_2371 6 None None None 118468914 Common dapB dihydrodipicolinate reductase, N-terminus domain protein MSMEG_0560 24 COG3804 COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase Function unknown 118473747 Common - hypothetical protein MSMEG_0065 1 None None None 118468096 Common - hypothetical protein MSMEG_0324 2 None None None 118469446 Common - 2-dehydro-3-deoxy-6-phosphogalactonate aldolase MSMEG_6176 124 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 118469034 Common - amino acid permease MSMEG_2184 56 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118473398 Common pth peptidyl-tRNA hydrolase MSMEG_5432 215 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 118472226 Common - ABC transporter permease protein MSMEG_2846 218 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118471525 Common - ABC-type amino acid transport system, secreted component MSMEG_3235 147 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 118472566 Common - hypothetical protein MSMEG_5026 6 None None None 118470845 Common - mce-family protein mce3c MSMEG_0348 27 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118468580 Common - sugar transporter MSMEG_2001 66 None None None 118468571 Common - flavin-containing monooxygenase FMO MSMEG_1682 63 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118470602 Common - linear gramicidin synthetase subunit B MSMEG_4511 215 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118471510 Common - Mrp protein MSMEG_5068 231 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 118473728 Common - hypothetical protein MSMEG_0669 6 None None None 118473902 Common - secreted protein MSMEG_5067 23 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 118469760 Common - NLP/P60 family protein MSMEG_6821 4 COG3170 FimV, Tfp pilus assembly protein FimV Cell motility and secretion / Intracellular trafficking and secretion 118472815 Common - transcriptional regulator MSMEG_6265 66 COG1396 HipB, Predicted transcriptional regulators Transcription 118472703 Common - IS1137, transposase orfA MSMEG_1720 37 None None None 118469911 Common - acetyltransferase, gnat family protein MSMEG_4548 4 COG0456 RimI, Acetyltransferases General function prediction only 118470400 Common - ISMsm8, transposase MSMEG_2675 64 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 118471263 Common - hypothetical protein MSMEG_6489 59 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118473323 Common - RNA methyltransferase, TrmH family protein, group 3 MSMEG_6073 213 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 118473355 Common - TetR family protein transcriptional regulator MSMEG_3469 20 None None None 118469400 Common - ABC-transporter integral membrane protein MSMEG_1142 149 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 118468715 Common - dihydroxyacetone kinase MSMEG_3271 77 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 118468880 Common - pyridoxine biosynthesis protein MSMEG_2937 87 COG0214 SNZ1, Pyridoxine biosynthesis enzyme Coenzyme metabolism 118468735 Common - transcriptional regulator, Ada family protein/DNA-3-methyladenine glycosylase II MSMEG_4925 119 COG0122 AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 118472646 Common uvrC excinuclease ABC subunit C MSMEG_3078 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 118467742 Common - branched chain amino acid transport ATP-binding protein MSMEG_6876 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 118473240 Common rpsH 30S ribosomal protein S8 MSMEG_1469 247 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 118467880 Common - two-component system response regulator MSMEG_4969 187 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118469022 Common - hemolysin A MSMEG_3751 134 COG1189 COG1189, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 118468702 Pathogen - hypothetical protein MSMEG_3327 1 None None None 118469812 Common - multidrug resistance protein, SMR family protein MSMEG_1659 119 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 118469604 Common alaS alanyl-tRNA synthetase MSMEG_3025 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 118470632 Common - hypothetical protein MSMEG_6129 2 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 118469806 Common - hypothetical protein MSMEG_6608 1 None None None 118473120 Common - secreted protein MSMEG_6049 17 None None None 118473490 Common - peptidase M52, hydrogen uptake protein MSMEG_3927 22 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 118469252 Common - carnitinyl-CoA dehydratase MSMEG_5198 178 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118468600 Common - lipolytic enzyme, G-D-S-L MSMEG_6317 13 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 118467909 Common - ferric enterobactin transport system permease protein FepD MSMEG_0012 191 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 118469378 Common ggt gamma-glutamyltranspeptidase MSMEG_1615 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 118469163 Common - pigment production hydroxylase MSMEG_6038 87 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118469500 Common - PAP2 superfamily protein MSMEG_0633 58 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 118470268 Common - hypothetical protein MSMEG_4796 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 118472255 Common - hypothetical protein MSMEG_5615 57 COG3542 COG3542, Uncharacterized conserved protein Function unknown 118467342 Common - hypothetical protein MSMEG_6252 3 None None None 118471601 Pathogen - hypothetical protein MSMEG_5806 1 None None None 118470091 Common - hypothetical protein MSMEG_4220 194 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 118471539 Common - oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_2876 220 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118470586 Common - hypothetical protein MSMEG_6454 101 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118470658 Common - Na+/solute symporter MSMEG_5166 126 COG4147 DhlC, Predicted symporter General function prediction only 118473330 Common - ABC transporter permease protein MSMEG_2845 209 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118473835 Common - arabitol-phosphate dehydrogenase MSMEG_3265 206 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 118467869 Common - transcriptional regulator, MarR family protein MSMEG_3284 22 COG1846 MarR, Transcriptional regulators Transcription 118472402 Common - transcriptional regulator, LysR family protein MSMEG_0156 186 COG0583 LysR, Transcriptional regulator Transcription 118468807 Common msrB methionine-R-sulfoxide reductase MSMEG_4418 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 118469110 Common - 23s ribosomal RNA methyltransferase MSMEG_5687 213 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 118473998 Common - L-carnitine dehydratase/bile acid-inducible protein F MSMEG_4834 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118467907 Common - MarR-family protein transcriptional regulator MSMEG_2538 6 COG1846 MarR, Transcriptional regulators Transcription 118470909 Common - protein IolB MSMEG_4663 51 COG3718 IolB, Uncharacterized enzyme involved in inositol metabolism Carbohydrate transport and metabolism 118473208 Common - ISMsm4, transposase MSMEG_0430 43 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118468987 Common - virulence factor Mce family protein MSMEG_0135 86 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118470096 Common - conserved hypothetical protein TIGR02611 MSMEG_2930 7 None None None 118470049 Common - hypothetical protein MSMEG_3695 5 None None None 118469201 Common leuS leucyl-tRNA synthetase MSMEG_6917 248 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 118473104 Common - bacterial regulatory protein, GntR family protein MSMEG_0895 135 COG2186 FadR, Transcriptional regulators Transcription 118469405 Common - hypothetical protein MSMEG_3098 2 None None None 118469045 Common - glycosyl transferase, family protein 39 MSMEG_4986 17 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 118470475 Common - lipid A biosynthesis lauroyl acyltransferase MSMEG_2934 45 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 118469578 Common - conserved hypothetical protein TIGR00026 MSMEG_3660 7 None None None 118470824 Common gabT 4-aminobutyrate aminotransferase MSMEG_2959 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 118471520 Common - hypothetical protein MSMEG_6336 1 COG5416 COG5416, Uncharacterized integral membrane protein Function unknown 118473870 Common - penicillin-binding protein, putative MSMEG_2584 168 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 118469040 Common - L-idonate 5-dehydrogenase MSMEG_2914 137 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 118473058 Common - hypothetical protein MSMEG_6770 9 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 118471564 Common - ABC transporter, membrane spanning protein, putative MSMEG_2499 162 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 118467983 Common - carbon monoxide dehydrogenase, medium chain MSMEG_2950 83 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 118471992 Common - cation-transporting ATPase Pma1 MSMEG_3926 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 118470227 Common nuoA NADH dehydrogenase subunit A MSMEG_2063 163 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 118472145 Common - intracellular protease, PfpI family protein MSMEG_0536 166 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 118469523 Common - hypothetical protein MSMEG_0248 6 COG0392 COG0392, Predicted integral membrane protein Function unknown 118473736 Common - Low molecular weight protein-tyrosine-phosphatase MSMEG_4309 134 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 118468607 Common - Transglycosylase MSMEG_6201 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 118467552 Common fdhD formate dehydrogenase accessory protein MSMEG_4669 137 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 118471932 Common snm secretion protein Snm4 MSMEG_0623 1 None None None 118467597 Common purM phosphoribosylaminoimidazole synthetase MSMEG_5798 228 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 118467814 Common - HTH-type transcriptional repressor AcnR MSMEG_3142 83 COG1309 AcrR, Transcriptional regulator Transcription 118467592 Common mtrA DNA-binding response regulator MtrA MSMEG_1874 213 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 118469593 Common - radical SAM domain protein MSMEG_0568 31 COG2516 COG2516, Biotin synthase-related enzyme General function prediction only 118470420 Common - MmpL4 protein MSMEG_0463 48 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118471494 Pathogen - hypothetical protein MSMEG_5230 1 None None None 118469328 Common - hypothetical protein MSMEG_4124 20 COG2079 PrpD, Uncharacterized protein involved in propionate catabolism General function prediction only 118470230 Common - short chain dehydrogenase MSMEG_0831 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118467598 Pathogen - hypothetical protein MSMEG_4137 1 None None None 118473203 Common - xylose repressor, ROK-family protein transcriptional regulator MSMEG_6022 167 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 118473686 Common - ABC transporter, ATP-binding protein MSMEG_5008 231 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 118468696 Common - major facilitator superfamily protein MFS_1 MSMEG_6027 161 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 118469948 Common - putative helicase MSMEG_4912 127 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 118467585 Common - hypothetical protein MSMEG_6601 2 None None None 118468788 Common - hypothetical protein MSMEG_1788 4 None None None 118469029 Common - hypothetical glycosyl transferase MSMEG_0392 39 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 118472774 Common - transcriptional regulator MSMEG_1799 182 COG0583 LysR, Transcriptional regulator Transcription 118468709 Common - hypothetical protein MSMEG_1253 3 None None None 118470793 Common - metal-dependent hydrolase MSMEG_3675 25 COG3687 COG3687, Predicted metal-dependent hydrolase General function prediction only 118470409 Common - FAD binding domain, putative MSMEG_1132 85 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 118471374 Common - LpqJ protein MSMEG_0704 1 None None None 118469527 Common - inner membrane ABC transporter permease protein YjfF MSMEG_1709 114 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 118469055 Common - hypothetical protein MSMEG_3798 2 None None None 118469813 Pathogen - hypothetical protein MSMEG_6470 1 None None None 118474040 Common dnaA chromosomal replication initiation protein MSMEG_6947 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 118472133 Common - hypothetical protein MSMEG_4810 10 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118470212 Common - transcriptional regulator, TetR family protein MSMEG_5040 6 COG1309 AcrR, Transcriptional regulator Transcription 118471180 Common - bacterial extracellular solute-binding protein, family protein 5 MSMEG_5130 37 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 118468658 Pathogen - hypothetical protein MSMEG_6893 1 None None None 118469418 Common - ribonuclease inhibitor MSMEG_0209 4 COG2732 COG2732, Barstar, RNAse (barnase) inhibitor Transcription 118468440 Common - transcriptional regulator MSMEG_0544 180 COG0583 LysR, Transcriptional regulator Transcription 118473612 Common - two-component system sensor kinase MSMEG_2248 102 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 118467627 Common - Transcription factor WhiB MSMEG_6199 19 None None None 118470255 Common - major facilitator superfamily protein MFS_1 MSMEG_5167 36 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118468033 Common - enoyl-CoA hydratase MSMEG_1390 176 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118468392 Common - hypothetical protein MSMEG_5933 17 COG1414 IclR, Transcriptional regulator Transcription 118471532 Common - hypothetical protein MSMEG_0892 2 None None None 118471999 Common - hypothetical protein MSMEG_0479 1 None None None 118473027 Common asd aspartate-semialdehyde dehydrogenase MSMEG_6256 236 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 118471046 Common - phosphoglycerate mutase family protein MSMEG_6416 71 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 118469451 Common - hypothetical protein MSMEG_2198 90 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 118467387 Common - hypothetical protein MSMEG_0672 8 None None None 118471899 Pathogen - hypothetical protein MSMEG_1869 1 None None None 118473090 Common - hypothetical protein MSMEG_0240 1 None None None 118468633 Common - carbon starvation protein A MSMEG_2259 106 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 118468053 Common - acetyl-CoA acetyltransferase MSMEG_5521 21 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118470677 Common - hypothetical protein MSMEG_5401 6 None None None 118470764 Common - integral membrane transport protein MSMEG_2044 135 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118471606 Common - SAM-dependent methyltransferase MSMEG_1050 19 COG1041 COG1041, Predicted DNA modification methylase DNA replication, recombination, and repair 118473956 Common - pyruvate synthase MSMEG_4646 106 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 118470681 Common - branched-chain alpha-keto acid dehydrogenase subunit E2 MSMEG_4710 196 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 118471890 Common - CobW/P47K C- domain protein MSMEG_6069 56 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 118467698 Common - hypothetical protein MSMEG_4811 1 None None None 118469008 Common - transcriptional regulator TetR family protein MSMEG_0285 25 COG1309 AcrR, Transcriptional regulator Transcription 118473844 Common - hypothetical protein MSMEG_2642 4 COG5552 COG5552, Uncharacterized conserved protein Function unknown 118468279 Pathogen - hypothetical protein MSMEG_5737 1 None None None 118473571 Common - major facilitator superfamily protein MSMEG_6490 129 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118471725 Common - regulatory protein GntR, HTH:GntR, C- MSMEG_2009 115 COG1802 GntR, Transcriptional regulators Transcription 118472524 Common - ABC Fe3+-siderophores transporter, periplasmic binding protein MSMEG_4561 111 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 118473669 Common - hypothetical protein MSMEG_4567 105 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 118468211 Common ehuC ectoine/hydroxyectoine ABC transporter, permease protein EhuC MSMEG_5369 173 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 118469017 Common - secreted protein MSMEG_4640 10 None None None 118472343 Common - bacterial regulatory protein, MarR family protein MSMEG_5724 36 COG1846 MarR, Transcriptional regulators Transcription 118467885 Common - hypothetical protein MSMEG_2957 2 None None None 118467875 Common dapB dihydrodipicolinate reductase MSMEG_4350 24 COG3804 COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase Function unknown 118467494 Common - molybdopterin biosynthesis-like protein MoeZ MSMEG_1937 227 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 118471224 Common - para-nitrobenzyl esterase MSMEG_0470 65 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 118468653 Common - spou rRNA methylase family protein MSMEG_0739 28 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 118468898 Common - monooxygenase MSMEG_1030 83 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118469192 Common - TetR-family protein transcriptional regulator MSMEG_1025 26 COG1309 AcrR, Transcriptional regulator Transcription 118469000 Common - hypothetical protein MSMEG_2983 1 None None None 118472826 Pathogen - hypothetical protein MSMEG_2714 1 None None None 118470265 Common - 29 kda antigen Cfp29 MSMEG_5830 20 COG1659 COG1659, Uncharacterized protein, linocin/CFP29 homolog Function unknown 118468317 Common - hypothetical protein MSMEG_2697 3 None None None 118469185 Common trpD anthranilate phosphoribosyltransferase MSMEG_4258 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 118467589 Common - isoprenylcysteine carboxyl methyltransferase MSMEG_0809 14 COG1755 COG1755, Uncharacterized protein conserved in bacteria Function unknown 118471170 Common - LppM protein MSMEG_4239 4 None None None 118468014 Pathogen - hypothetical protein MSMEG_0776 1 None None None 118472458 Common - transcriptional regulator, IclR family protein, C- domain protein MSMEG_4868 83 COG1414 IclR, Transcriptional regulator Transcription 118474047 Pathogen - hypothetical protein MSMEG_6429 1 None None None 118467824 Common - aldehyde dehydrogenase MSMEG_2597 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118473665 Common - Fatty acid desaturase MSMEG_1743 35 COG3239 DesA, Fatty acid desaturase Lipid metabolism 118469625 Common - 3-hydroxybutyrate dehydrogenase MSMEG_6026 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470352 Common - 1-phosphofructokinase MSMEG_1378 87 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 118471552 Common - FAD dependent oxidoreductase MSMEG_5532 8 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 118472176 Common - hypothetical protein MSMEG_2341 15 None None None 118472809 Common - hypothetical protein MSMEG_2585 12 None None None 118468121 Common algD GDP-mannose 6-dehydrogenase AlgD MSMEG_5957 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 118469137 Common - major facilitator family protein transporter MSMEG_0103 88 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118472810 Common - putative monooxygenase MSMEG_2841 73 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118470359 Common - piperideine-6-carboxylic acid dehydrogenase MSMEG_1762 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118471179 Common - methylmalonyl-CoA carboxyltransferase 12S subunit MSMEG_6577 145 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 118472942 Common - putative ScnB protein MSMEG_6268 3 None None None 118471353 Common - hydrolase, alpha/beta fold family protein MSMEG_6710 26 COG2267 PldB, Lysophospholipase Lipid metabolism 118469432 Common kdpB potassium-transporting ATPase subunit B MSMEG_5393 232 COG2216 KdpB, High-affinity K+ transport system, ATPase chain B Inorganic ion transport and metabolism 118472968 Common fumC fumarate hydratase MSMEG_5240 236 COG0114 FumC, Fumarase Energy production and conversion 118469906 Common - amidohydrolase family protein MSMEG_0445 110 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 118473558 Common - MmpL protein MSMEG_0410 40 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118472079 Common - hypothetical protein MSMEG_3489 4 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 118470157 Common - limonene 1,2-monooxygenase MSMEG_6107 119 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118471256 Pathogen - hypothetical protein MSMEG_6681 1 None None None 118469870 Common - bifunctional short chain isoprenyl diphosphate synthase MSMEG_1133 241 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 118469719 Common - alanine and proline-rich secreted protein apa MSMEG_3618 1 COG4982 COG4982, 3-oxoacyl- acyl-carrier protein 118467879 Common ppc phosphoenolpyruvate carboxylase MSMEG_3097 118 COG2352 Ppc, Phosphoenolpyruvate carboxylase Energy production and conversion 118468428 Common - putative secreted protein MSMEG_3494 1 None None None 118470912 Common - probable enoyl-CoA hydratase MSMEG_6777 177 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118469856 Common - alcohol dehydrogenase MSMEG_2079 93 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118471835 Common - proline-rich 28 kDa antigen MSMEG_6919 1 None None None 118471296 Common - thermolabile glutaminase MSMEG_3818 72 COG2066 GlsA, Glutaminase Amino acid transport and metabolism 118474003 Common - GntR-family protein transcriptional regulator MSMEG_4140 167 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 118472754 Common - hypothetical protein MSMEG_0813 1 None None None 118469498 Common phoU phosphate transport system regulatory protein PhoU MSMEG_5776 191 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 118471013 Common - hypothetical protein MSMEG_0966 3 None None None 118473579 Common - oxidoreductase MSMEG_3462 76 COG0778 NfnB, Nitroreductase Energy production and conversion 118473039 Pathogen - hypothetical protein MSMEG_0278 1 None None None 118467444 Common - short chain dehydrogenase MSMEG_1894 211 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471364 Common - IS1096, tnpA protein MSMEG_0202 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118467781 Common - hypothetical protein MSMEG_5792 15 None None None 118467720 Common - inositol-1-monophosphatase MSMEG_3116 185 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 118470241 Common - hypothetical protein MSMEG_4365 7 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 118468757 Common - hypothetical protein MSMEG_0683 2 None None None 118471589 Common dnaE2 error-prone DNA polymerase MSMEG_1633 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 118473062 Common aroE shikimate 5-dehydrogenase MSMEG_3028 206 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 118469010 Common - hypothetical protein MSMEG_4479 5 None None None 118472354 Common - IclR-family protein transcriptional regulator MSMEG_2507 120 COG1414 IclR, Transcriptional regulator Transcription 118470052 Common eutB ethanolamine ammonia-lyase, large subunit MSMEG_1553 55 COG4303 EutB, Ethanolamine ammonia-lyase, large subunit Amino acid transport and metabolism 118467953 Common - D-lactate dehydrogenase MSMEG_2492 203 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 118471293 Common - Sfp-type phosphopantetheinyl transferase MSMEG_2648 35 COG2977 EntD, Phosphopantetheinyl transferase component of siderophore synthetase Secondary metabolites biosynthesis, transport, and catabolism 118467802 Common pyrD dihydroorotate dehydrogenase 2 MSMEG_4198 232 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 118470180 Common - quinone oxidoreductase MSMEG_6362 192 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118470164 Common - amino acid permease MSMEG_3821 102 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118469554 Common - hypothetical protein MSMEG_5279 9 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 118471243 Pathogen - hypothetical protein MSMEG_6721 1 None None None 118471349 Common dapB dihydrodipicolinate reductase, N-terminus domain protein MSMEG_0733 23 COG3804 COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase Function unknown 118472372 Common folP dihydropteroate synthase MSMEG_5085 216 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 118473257 Common lys1 saccharopine dehydrogenase MSMEG_6311 54 COG1748 LYS9, Saccharopine dehydrogenase and related proteins Amino acid transport and metabolism 118469680 Pathogen - hypothetical protein MSMEG_6323 1 None None None 118468484 Common - thymidylate kinase MSMEG_1873 29 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 118470871 Common - hydrolase, alpha/beta fold family protein MSMEG_6184 131 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118470823 Common - putative transport protein MSMEG_0382 59 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118467483 Common - superfamily protein I DNA or RNA helicase MSMEG_2174 31 COG3973 COG3973, Superfamily I DNA and RNA helicases General function prediction only 118468966 Common - probable conserved integral membrane protein MSMEG_4247 12 COG5650 COG5650, Predicted integral membrane protein Function unknown 118471942 Common - L-carnitine dehydratase/bile acid-inducible protein F MSMEG_5623 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118468948 Common - non-heme bromoperoxidase BPO-A2 MSMEG_4707 102 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118467555 Common rpsT 30S ribosomal protein S20 MSMEG_4571 50 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 118473172 Common - hypothetical protein MSMEG_5208 5 None None None 118473652 Common - hypothetical protein MSMEG_5710 1 None None None 118471877 Common - hypothetical protein MSMEG_1733 8 None None None 118470876 Common - hypothetical protein MSMEG_1891 108 COG2135 COG2135, Uncharacterized conserved protein Function unknown 118470860 Common amiF formamidase MSMEG_3403 135 COG0388 COG0388, Predicted amidohydrolase General function prediction only 118471711 Common - hypothetical protein MSMEG_1035 8 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 118472664 Pathogen - hypothetical protein MSMEG_5417 1 None None None 118472900 Common rplE 50S ribosomal protein L5 MSMEG_1467 244 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 118469286 Common - chitin synthase MSMEG_0476 89 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 118467682 Common - metal-dependent phosphohydrolase MSMEG_3487 23 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 118469581 Common serS seryl-tRNA synthetase MSMEG_6413 243 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 118468333 Common - O-methyltransferase, family protein 3 MSMEG_5073 95 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 118470429 Common - oxidoreductase, GMC family protein MSMEG_0526 88 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 118472788 Common - putative thiosulfate sulfurtransferase MSMEG_5789 144 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 118471504 Common - aldehyde dehydrogenase MSMEG_6874 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118473195 Common - hypothetical protein MSMEG_3518 6 None None None 118471234 Common - hypothetical protein MSMEG_0365 2 COG4842 COG4842, Uncharacterized protein conserved in bacteria Function unknown 118473818 Common - gluconate 5-dehydrogenase MSMEG_3420 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118472674 Common - pyridoxamine 5'-phosphate oxidase family protein MSMEG_6519 32 COG0748 HugZ, Putative heme iron utilization protein Inorganic ion transport and metabolism 118471952 Common - putative transcriptional regulator MSMEG_0091 21 COG1309 AcrR, Transcriptional regulator Transcription 118468529 Common - clavaldehyde dehydrogenase MSMEG_4742 172 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118471814 Common - forkhead-associated protein MSMEG_3647 66 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 118467624 Common - transcriptional regulator, LysR family protein MSMEG_0104 190 COG0583 LysR, Transcriptional regulator Transcription 118473504 Common - RNA pseudouridine synthase family protein MSMEG_1737 214 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 118470859 Common - probable conserved transmembrane protein MSMEG_1738 4 None None None 118469820 Common - acyltransferase domain protein MSMEG_0305 21 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 118469238 Common - enoyl-CoA hydratase MSMEG_1331 114 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118473527 Common - acyl-CoA dehydrogenase MSMEG_2650 123 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473344 Common - transcriptional regulator MSMEG_6762 61 COG1777 COG1777, Predicted transcriptional regulators Transcription 118471345 Common - hypothetical protein MSMEG_0881 8 COG2852 COG2852, Uncharacterized protein conserved in bacteria Function unknown 118470328 Common - glycosyl transferase, group 2 family protein MSMEG_3859 155 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 118471849 Common atpD F0F1 ATP synthase subunit beta MSMEG_4936 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 118472937 Common - carboxymuconolactone decarboxylase MSMEG_6536 28 COG2128 COG2128, Uncharacterized conserved protein Function unknown 118473248 Common - nitrate/nitrite transporter protein MSMEG_5141 118 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 118472711 Pathogen - hypothetical protein MSMEG_5889 1 None None None 118468640 Common - short chain dehydrogenase MSMEG_1114 233 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118469485 Common - sugar transport protein MSMEG_3536 117 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118473278 Common - probable serine/threonine-protein kinase PknH, putative MSMEG_4554 1 None None None 118469922 Common - enoyl-CoA hydratase/isomerase family protein MSMEG_2223 157 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118472533 Common - zinc metalloprotease MSMEG_2579 209 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 118468828 Common - RNA polymerase sigma factor SigL MSMEG_1486 144 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118473581 Common - caax amino protease family protein, putative MSMEG_6825 4 COG4449 COG4449, Predicted protease of the Abi (CAAX) family General function prediction only 118473803 Common - hydrolase, alpha/beta fold family protein, putative MSMEG_4860 107 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118470220 Common - hypothetical protein MSMEG_6445 83 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 118473413 Common - putative peroxisomal multifunctional enzyme type 2 MSMEG_5943 26 COG2030 MaoC, Acyl dehydratase Lipid metabolism 118472006 Common - regulatory protein, TetR MSMEG_3363 108 COG1309 AcrR, Transcriptional regulator Transcription 118470208 Common - putative transcriptional regulator MSMEG_5668 4 COG1846 MarR, Transcriptional regulators Transcription 118467349 Pathogen - hypothetical protein MSMEG_3454 1 None None None 118472983 Common - hypothetical protein MSMEG_0271 18 None None None 118469732 Common - hypothetical protein MSMEG_0337 36 None None None 118467977 Common - Clp amino terminal domain protein MSMEG_2792 104 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 118472696 Common valS valyl-tRNA synthetase MSMEG_4630 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 118470515 Common - hypothetical protein MSMEG_2887 5 None None None 118468245 Common - epoxide hydrolase MSMEG_6106 143 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118467575 Common - LacI-family protein transcriptional regulator MSMEG_1369 127 COG1609 PurR, Transcriptional regulators Transcription 118469354 Common - valosin containing protein-1 MSMEG_1854 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 118470468 Common - GntR-family protein transcriptional regulator MSMEG_0650 73 COG2188 PhnF, Transcriptional regulators Transcription 118468130 Common mmsA methylmalonate-semialdehyde dehydrogenase MSMEG_1498 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118468454 Common - hypothetical protein MSMEG_2446 42 COG3651 COG3651, Uncharacterized protein conserved in bacteria Function unknown 118469259 Common - ribose 5-phosphate isomerase MSMEG_6787 125 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 118470697 Common mmsB 3-hydroxyisobutyrate dehydrogenase MSMEG_1496 187 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 118473155 Common - glutaredoxin 2 MSMEG_0951 20 None None None 118473481 Common - hypothetical protein MSMEG_1990 19 None None None 118471479 Common - acetaldehyde dehydrogenase MSMEG_5939 37 COG4569 MhpF, Acetaldehyde dehydrogenase (acetylating) Secondary metabolites biosynthesis, transport, and catabolism 118467914 Common - haloacetate dehalogenase H-1 MSMEG_1984 112 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118470637 Common - DivIVA protein MSMEG_4217 38 COG3599 DivIVA, Cell division initiation protein Cell division and chromosome partitioning 118473723 Common - lipase MSMEG_3197 18 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 118472924 Common - putative monovalent cation/H+ antiporter subunit F MSMEG_0844 4 COG2212 MnhF, Multisubunit Na+/H+ antiporter, MnhF subunit Inorganic ion transport and metabolism 118467870 Common - [2Fe-2S] binding domain protein MSMEG_2951 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 118471418 Common - putative two-component system sensor kinase MSMEG_6238 134 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 118472476 Common - carbon-monoxide dehydrogenase MSMEG_2462 106 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 118472494 Common - dipeptide transport system permease protein DppB MSMEG_1085 218 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118472618 Common - ABC transporter, permease protein MSMEG_0506 143 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 118469353 Common - NAD-dependent epimerase/dehydratase MSMEG_0991 223 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118469377 Pathogen - hypothetical protein MSMEG_2176 1 COG1990 COG1990, Uncharacterized conserved protein Function unknown 118470977 Common - ISMsm1, transposase orfA MSMEG_5096 34 None None None 118468205 Common metZ O-succinylhomoserine sulfhydrylase MSMEG_0769 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 118468500 Pathogen - hypothetical protein MSMEG_2527 1 None None None 118473922 Common - T/U mismatch-specific DNA glycosylase MSMEG_5024 42 COG3663 Mug, G:T/U mismatch-specific DNA glycosylase DNA replication, recombination, and repair 118469439 Common - putative acyl-CoA dehydrogenase MSMEG_5906 152 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472499 Common folK 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase MSMEG_6101 184 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 118468976 Common - L-carnitine dehydratase/bile acid-inducible protein F MSMEG_3981 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118468892 Common - biphenyl-2,3-diol 1,2-dioxygenase 1 MSMEG_2891 26 None None None 118469214 Common mraZ hypothetical protein MSMEG_4236 133 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 118472106 Common - binding-protein-dependent transport systems inner membrane component MSMEG_4523 186 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 118473136 Common - hypothetical protein MSMEG_0823 7 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 118471192 Common - hypothetical protein MSMEG_3546 6 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 118473456 Common - phosphoglycerate mutase family protein MSMEG_4193 92 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 118467355 Common - acetyl-coenzyme A synthetase MSMEG_6179 217 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 118467460 Common - putative periplasmic solute-binding protein MSMEG_0122 76 COG3181 COG3181, Uncharacterized protein conserved in bacteria Function unknown 118467932 Common - putative esterase MSMEG_3842 26 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118467958 Common - HD domain protein MSMEG_0890 21 None None None 118468810 Common - aliphatic nitrilase MSMEG_4138 62 COG0388 COG0388, Predicted amidohydrolase General function prediction only 118473752 Common purD phosphoribosylamine--glycine ligase MSMEG_5852 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 118468353 Common - probable conserved mce associated transmembrane protein MSMEG_0141 4 COG1714 COG1714, Predicted membrane protein/domain Function unknown 118468300 Common - hypothetical protein MSMEG_1790 8 None None None 118470662 Common nuoK NADH dehydrogenase subunit K MSMEG_2053 163 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 118469860 Common hypD hydrogenase expression/formation protein HypD MSMEG_2702 109 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 118473328 Common - hypothetical protein MSMEG_3817 6 COG2306 COG2306, Uncharacterized conserved protein Function unknown 118470132 Common - epoxide hydrolase MSMEG_5658 53 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118472963 Common - hypothetical protein MSMEG_3620 71 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118469618 Common - ABC transporter ATP-binding protein MSMEG_3762 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 118472742 Common - putative monovalent cation/H+ antiporter subunit G MSMEG_0843 64 COG1320 MnhG, Multisubunit Na+/H+ antiporter, MnhG subunit Inorganic ion transport and metabolism 118471036 Common - nudix hydrolase MSMEG_2327 41 None None None 118472687 Common pheS phenylalanyl-tRNA synthetase subunit alpha MSMEG_3778 248 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 118469083 Common - hypothetical protein MSMEG_3685 3 None None None 118468507 Common - glyoxalase/bleomycin resistance protein/dioxygenase MSMEG_1021 43 COG3607 COG3607, Predicted lactoylglutathione lyase General function prediction only 118470368 Common - hydrolase, alpha/beta fold family protein MSMEG_4998 1 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118473365 Common - taurine transport system permease protein TauC MSMEG_1161 198 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 118467868 Common - pyridoxamine 5'-phosphate oxidase family protein MSMEG_3863 12 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 118467739 Pathogen - hypothetical protein MSMEG_5965 1 None None None 118468853 Common - hypothetical protein MSMEG_0183 1 None None None 118472652 Common ectA L-2,4-diaminobutyric acid acetyltransferase MSMEG_3901 29 COG3818 COG3818, Predicted acetyltransferase, GNAT superfamily General function prediction only 118468178 Common - transcriptional regulator, MarR family protein MSMEG_0296 65 COG1846 MarR, Transcriptional regulators Transcription 118473281 Common - carbohydrate kinase, fggy MSMEG_3113 179 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 118472722 Common - transport gene MSMEG_2952 163 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118469842 Common - hypothetical protein MSMEG_3649 20 COG3879 COG3879, Uncharacterized protein conserved in bacteria Function unknown 118469996 Common - transcriptional regulator, TetR family protein, putative MSMEG_4070 11 COG1309 AcrR, Transcriptional regulator Transcription 118470444 Common - hypothetical protein MSMEG_1539 2 COG4842 COG4842, Uncharacterized protein conserved in bacteria Function unknown 118467418 Common - hypothetical protein MSMEG_5726 9 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 118469528 Common carB carbamoyl phosphate synthase large subunit MSMEG_3047 234 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 118469509 Common - O-antigen export system, ATP-binding protein MSMEG_6366 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 118468145 Common bfr bacterioferritin MSMEG_3564 105 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 118469369 Common - ABC-transporter integral membrane protein MSMEG_4795 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 118468649 Common - tuberculin related peptide MSMEG_0834 3 None None None 118470608 Common - phosphotransferase enzyme family protein, putative MSMEG_4981 58 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 118470321 Common - alkane 1-monooxygenase MSMEG_1839 26 COG3239 DesA, Fatty acid desaturase Lipid metabolism 118473627 Common psd phosphatidylserine decarboxylase MSMEG_0861 90 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 118470704 Common hypB hydrogenase accessory protein HypB MSMEG_2721 127 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 118470128 Common - enoyl-CoA hydratase MSMEG_1594 180 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118472020 Common - hypothetical protein MSMEG_2710 3 None None None 118468168 Common - acetyl-CoA acetyltransferase MSMEG_0373 167 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118471755 Common - isochorismatase hydrolase MSMEG_4976 99 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 118470592 Common - exopolyphosphatase MSMEG_5413 177 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 118471097 Common - KanY protein MSMEG_6282 6 None None None 118467510 Common - cobyrinic Acid a,c-diamide synthase MSMEG_1927 230 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 118473349 Common - ABC transporter system integral membrane protein MSMEG_4543 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118471087 Common - hydride transferase 1 MSMEG_2811 80 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118469287 Common - glyoxalase/bleomycin resistance protein/dioxygenase MSMEG_5616 42 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 118472909 Common - arginine decarboxylase MSMEG_0266 83 COG1982 LdcC, Arginine/lysine/ornithine decarboxylases Amino acid transport and metabolism 118471422 Common - NADPH-dependent fmn reductase MSMEG_2800 42 COG0431 COG0431, Predicted flavoprotein General function prediction only 118468309 Common - TnpC protein MSMEG_6654 6 None None None 118468616 Common rplL 50S ribosomal protein L7/L12 MSMEG_1365 204 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 118469611 Common - transcriptional regulatory protein CitT MSMEG_4212 222 COG4565 CitB, Response regulator of citrate/malate metabolism Transcription / Signal transduction mechanisms 118471152 Pathogen - hypothetical protein MSMEG_5294 1 None None None 118471003 Common - acyl-CoA synthetase MSMEG_2231 208 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118471864 Common - sensor-type histidine kinase PrrB MSMEG_0246 179 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 118473715 Pathogen - hypothetical protein MSMEG_0893 1 None None None 118468813 Pathogen - hypothetical protein MSMEG_1767 1 None None None 118473656 Common - D-serine/D-alanine/glycine transporter MSMEG_3587 148 COG1113 AnsP, Gamma-aminobutyrate permease and related permeases Amino acid transport and metabolism 118469588 Common - hypothetical ABC transporter permease protein YliD MSMEG_0642 219 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118473088 Common - hypothetical protein MSMEG_3590 8 COG3662 COG3662, Uncharacterized protein conserved in bacteria Function unknown 118470593 Common - toluate 1,2-dioxygenase beta subunit MSMEG_1907 22 COG5517 COG5517, Small subunit of phenylpropionate dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 118469260 Common - hypothetical protein MSMEG_6551 1 None None None 118469882 Common - ATP/GTP-binding integral membrane protein MSMEG_2788 94 COG1485 COG1485, Predicted ATPase General function prediction only 118468198 Common - major facilitator superfamily protein MSMEG_5051 128 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118468126 Pathogen - hypothetical protein MSMEG_5098 1 None None None 118470455 Common - amidohydrolase, AtzE family protein MSMEG_2986 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 118470079 Common - phosphotransferase enzyme family protein MSMEG_3846 16 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 118471610 Common - D-oliose 4-ketoreductase MSMEG_4652 130 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 118467738 Pathogen - hypothetical protein MSMEG_6034 1 None None None 118472508 Common - hypothetical protein MSMEG_1265 33 None None None 118472701 Common - membrane-bound oxidoreductase MSMEG_2278 112 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 118471869 Common - hypothetical protein MSMEG_2897 10 COG3603 COG3603, Uncharacterized conserved protein Function unknown 118471453 Common - hypothetical protein MSMEG_4578 3 None None None 118468114 Common - DeoR-family protein transcriptional regulator MSMEG_1377 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 118470367 Common - purine nucleoside phosphorylase MSMEG_1701 104 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 118471463 Common - hypothetical protein MSMEG_1422 5 None None None 118470864 Common - transcriptional regulator MSMEG_1380 65 COG1309 AcrR, Transcriptional regulator Transcription 118471143 Common - methyltransferase MSMEG_1481 18 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118469725 Common glcB malate synthase G MSMEG_3640 70 COG2225 AceB, Malate synthase Energy production and conversion 118468963 Pathogen - hypothetical protein MSMEG_0955 1 None None None 118473708 Common - integral membrane transport protein MSMEG_3398 143 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118470320 Common trmB tRNA (guanine-N(7))-methyltransferase MSMEG_0252 174 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 118471850 Common - isonitrile hydratase, putative MSMEG_1107 129 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 118468679 Common - mannose-binding lectin MSMEG_3662 40 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 118470176 Common - RNA polymerase sigma factor SigD MSMEG_1599 56 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118472948 Common - D-alanyl-D-alanine carboxypeptidase family protein MSMEG_1900 10 COG1876 VanY, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 118472882 Common - nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase MSMEG_3347 202 COG0388 COG0388, Predicted amidohydrolase General function prediction only 118469531 Pathogen - BmyD protein MSMEG_4017 1 None None None 118474023 Common - soul heme-binding protein MSMEG_3082 20 None None None 118472914 Common - transcriptional regulator, TetR family protein MSMEG_4718 98 COG1309 AcrR, Transcriptional regulator Transcription 118471212 Common glnD PII uridylyl-transferase MSMEG_2427 124 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 118468596 Common - hypothetical protein MSMEG_0447 89 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 118471793 Common - 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_3830 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118474048 Common - putative enoyl-CoA hydratase MSMEG_6558 8 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118468278 Pathogen - hypothetical protein MSMEG_4575 1 None None None 118472283 Common - hypothetical protein MSMEG_0741 27 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118473864 Common - hypothetical protein MSMEG_4255 7 None None None 118473886 Common - hypothetical protein MSMEG_5131 1 None None None 118473263 Common - Ser/Thr protein phosphatase family protein MSMEG_1269 62 None None None 118469768 Common rpoC DNA-directed RNA polymerase subunit beta' MSMEG_1368 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 118473069 Common - mycocerosic acid synthase MSMEG_4727 216 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118472152 Common - hypothetical protein MSMEG_4066 34 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 118469877 Common - xanthine/uracil permease MSMEG_0564 135 COG2252 COG2252, Permeases General function prediction only 118468464 Common - DNA-binding response regulator, LuxR family protein MSMEG_0856 216 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118468327 Common - immunogenic protein MSMEG_0982 90 COG2358 Imp, TRAP-type uncharacterized transport system, periplasmic component General function prediction only 118467557 Common - cytochrome c oxidase subunit 3 MSMEG_4260 159 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 118470476 Common - AMP-dependent synthetase and ligase MSMEG_4019 221 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118473077 Pathogen - hypothetical protein MSMEG_4600 1 None None None 118471491 Common - ParB-like partition proteins MSMEG_6938 183 COG1475 Spo0J, Predicted transcriptional regulators Transcription 118467648 Common - starvation-inducible DNA-binding protein or fine tangled pili major subunit MSMEG_3242 125 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 118473157 Common - hypothetical protein MSMEG_1199 12 COG0392 COG0392, Predicted integral membrane protein Function unknown 118467967 Common - anti-sigma factor, family protein MSMEG_1915 13 None None None 118473880 Common - methyltransferase MSMEG_0614 30 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118471639 Common - integral membrane protein MSMEG_1530 90 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 118471034 Common - hypothetical protein MSMEG_6414 6 COG5373 COG5373, Predicted membrane protein Function unknown 118467798 Common - ATPase, AAA family protein MSMEG_0615 68 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 118470116 Common - hypothetical protein MSMEG_4689 1 None None None 118471018 Common - hypothetical protein MSMEG_6497 2 None None None 118472737 Common - TetR-type transcriptional regulator of sulfur metabolism MSMEG_4517 78 COG1309 AcrR, Transcriptional regulator Transcription 118473377 Common - hypothetical protein MSMEG_1248 2 None None None 118472053 Common rpsG 30S ribosomal protein S7 MSMEG_1399 245 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 118469963 Common xfp putative phosphoketolase MSMEG_3611 65 COG3957 COG3957, Phosphoketolase Carbohydrate transport and metabolism 118469348 Common treS trehalose synthase MSMEG_6515 170 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 118468191 Common - amino acid permease MSMEG_6701 162 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118468085 Common - putative acyl-CoA dehydrogenase MSMEG_4845 35 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473593 Common trmU tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase MSMEG_2358 215 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 118470408 Common - hypothetical protein MSMEG_3718 3 COG3339 COG3339, Uncharacterized conserved protein Function unknown 118470562 Common - hypothetical protein MSMEG_6694 13 COG1141 Fer, Ferredoxin Energy production and conversion 118473509 Common - regulatory protein MSMEG_6869 132 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 118470066 Common - hypothetical protein MSMEG_0601 3 None None None 118472886 Common - regulatory protein MSMEG_1068 28 COG3835 CdaR, Sugar diacid utilization regulator Transcription / Signal transduction mechanisms 118473754 Common - short chain dehydrogenase MSMEG_0524 238 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118467890 Common panC pantoate--beta-alanine ligase MSMEG_6097 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 118469122 Common - RNA polymerase sigma factor RpoD MSMEG_2758 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 118472134 Common - hypothetical protein MSMEG_6171 14 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 118470290 Common - integral membrane protein MSMEG_3631 16 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 118470718 Common - hypothetical protein MSMEG_6447 1 None None None 118472864 Common - glutaredoxin MSMEG_2297 37 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 118472959 Common - cystathionine beta-synthase MSMEG_5270 221 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 118468296 Common - integral membrane protein DUF6 MSMEG_3305 15 None None None 118471333 Pathogen - hypothetical protein MSMEG_0800 1 None None None 118471931 Common - alpha-methylacyl-CoA racemase MSMEG_5734 114 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118472349 Common - HNH nuclease, putative MSMEG_1275 11 COG1403 McrA, Restriction endonuclease Defense mechanisms 118471435 Common - ribosomal large subunit pseudouridine synthase D MSMEG_3175 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 118470504 Common - hypothetical protein MSMEG_0957 1 None None None 118472941 Common - DNA-binding protein MSMEG_6643 47 COG3800 COG3800, Predicted transcriptional regulator General function prediction only 118472682 Common purT phosphoribosylglycinamide formyltransferase 2 MSMEG_0766 195 COG0027 PurT, Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) Nucleotide transport and metabolism 118472387 Common - ribose operon repressor, putative MSMEG_1708 128 COG1609 PurR, Transcriptional regulators Transcription 118472599 Common - amidohydrolase family protein MSMEG_2230 19 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118468350 Common - integral membrane protein MSMEG_6216 9 None None None 118468951 Common - probable arabinosyltransferase B MSMEG_6388 5 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 118473050 Common - short-chain dehydrogenase/reductase MSMEG_3451 225 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118467897 Common - acetyltransferase, gnat family protein, putative MSMEG_1001 8 COG0456 RimI, Acetyltransferases General function prediction only 118468959 Common - ferritin family protein MSMEG_6422 77 COG1528 Ftn, Ferritin-like protein Inorganic ion transport and metabolism 118468430 Common - type I phosphodiesterase / nucleotide pyrophosphatase superfamily protein MSMEG_6672 15 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 118470866 Pathogen - hypothetical protein MSMEG_1916 1 None None None 118469917 Common - excalibur domain family protein MSMEG_4395 11 None None None 118469778 Common ung uracil-DNA glycosylase MSMEG_2399 129 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 118468683 Common - hypothetical protein MSMEG_5529 67 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 118471001 Common aceA isocitrate lyase MSMEG_3706 123 COG2224 AceA, Isocitrate lyase Energy production and conversion 118467641 Common - regulatory protein MSMEG_6705 118 COG1414 IclR, Transcriptional regulator Transcription 118471151 Common - putative acyl-CoA dehydrogenase MSMEG_3393 9 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118469387 Common - alcohol dehydrogenase B MSMEG_4167 208 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 118470887 Common - virulence factor Mce family protein MSMEG_5896 9 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118468413 Common - acetoin(diacetyl) reductase MSMEG_5020 237 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118467758 Common - hypothetical protein MSMEG_6771 6 None None None 118473899 Pathogen - hypothetical protein MSMEG_3502 1 None None None 118469651 Common - transporter, small multidrug resistance (SMR) family protein MSMEG_3672 134 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 118472796 Common - ECF-family protein sigma factor H MSMEG_3296 162 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118468299 Common - LprC protein MSMEG_5005 3 None None None 118473897 Common - probable conserved transmembrane protein MSMEG_0068 4 None None None 118471965 Common - N-carbamoyl-L-amino acid amidohydrolase MSMEG_0819 84 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 118473047 Common - ABC transporter, ATP-binding protein SugC MSMEG_5058 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 118473006 Common - hypothetical protein MSMEG_4698 19 COG0824 FcbC, Predicted thioesterase General function prediction only 118469248 Pathogen - hypothetical protein MSMEG_6516 1 None None None 118469714 Common - sulfatase-modifying factor 1 MSMEG_1226 97 COG1262 COG1262, Uncharacterized conserved protein Function unknown 118470557 Common - hypothetical protein MSMEG_2586 2 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 118468519 Common - hypothetical protein MSMEG_6528 3 None None None 118468063 Common - Rieske [2Fe-2S] domain protein MSMEG_5627 81 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 118472309 Common - thiredoxin MSMEG_5786 107 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 118468446 Common - virginiamycin B hydrolase MSMEG_4914 37 COG4257 Vgb, Streptogramin lyase Defense mechanisms 118467604 Common - regulatory protein, MarR MSMEG_1696 84 COG1846 MarR, Transcriptional regulators Transcription 118474054 Common - ABC transporter membrane-spanning protein MSMEG_5076 17 COG3559 TnrB3, Putative exporter of polyketide antibiotics Cell envelope biogenesis, outer membrane 118468670 Common dapE dipeptidase MSMEG_5103 196 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 118472852 Common - hypothetical protein MSMEG_3674 1 None None None 118471250 Pathogen - hypothetical protein MSMEG_6438 1 None None None 118470426 Common - ribose ABC transporter, periplasmic binding protein MSMEG_1374 105 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118469801 Common - hypothetical protein MSMEG_0761 1 COG1141 Fer, Ferredoxin Energy production and conversion 118468240 Pathogen - hypothetical protein MSMEG_6270 1 None None None 118473343 Common - ChaB protein MSMEG_1802 10 None None None 118469701 Common ispE 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase MSMEG_5436 188 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 118471593 Pathogen - hypothetical protein MSMEG_3104 1 None None None 118472493 Common - transcriptional regulator, BadM/Rrf2 family protein MSMEG_1335 88 COG1959 COG1959, Predicted transcriptional regulator Transcription 118471837 Common secA preprotein translocase subunit SecA MSMEG_1881 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 118467662 Common - putative membrane protein DcsA MSMEG_0425 40 None None None 118473000 Common - tena/thi-4 family protein MSMEG_3478 75 COG0819 TenA, Putative transcription activator Transcription 118472709 Common - hypothetical protein MSMEG_5387 31 COG0730 COG0730, Predicted permeases General function prediction only 118470738 Common - hypothetical protein MSMEG_5971 6 None None None 118468292 Common - TetR family protein transcriptional regulator MSMEG_3452 58 COG1309 AcrR, Transcriptional regulator Transcription 118471133 Common - F0F1 ATP synthase subunit B MSMEG_4940 90 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 118472296 Common - thioesterase family protein MSMEG_2866 17 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 118473780 Common - translation initiation inhibitor MSMEG_2454 90 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 118470799 Common - 3-isopropylmalate dehydrogenase MSMEG_3285 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 118471619 Common - ribosomal RNA adenine dimethylase family protein MSMEG_1646 146 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 118469555 Common - pyrimidine-specific ribonucleoside hydrolase RihA MSMEG_1621 80 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 118467773 Common - amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine MSMEG_6594 174 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 118472420 Common - cysteine synthase/cystathionine beta-synthase family protein MSMEG_6203 181 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 118470566 Common - hypothetical protein MSMEG_6255 6 None None None 118473664 Pathogen - hypothetical protein MSMEG_2322 1 None None None 118470211 Common - hypothetical protein MSMEG_3589 2 None None None 118468249 Common - putative transcriptional regulator MSMEG_1648 17 COG1309 AcrR, Transcriptional regulator Transcription 118469872 Common - transcriptional regulator, TetR family protein MSMEG_2195 51 COG1309 AcrR, Transcriptional regulator Transcription 118473703 Common - acetyl-CoA carboxylase carboxyltransferase MSMEG_5492 151 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 118470725 Common - ABC transporter branched chain amino acid transport permease MSMEG_3248 143 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 118470349 Pathogen - hypothetical protein MSMEG_2160 1 None None None 118469421 Common - transcriptional regulator MSMEG_4430 85 COG2909 MalT, ATP-dependent transcriptional regulator Transcription 118472194 Common - enoyl-CoA hydratase/isomerase family protein MSMEG_0340 156 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118468439 Common - creatininase subfamily protein MSMEG_1425 78 COG1402 COG1402, Uncharacterized protein, putative amidase General function prediction only 118469414 Common - HNH endonuclease domain protein MSMEG_2148 8 COG1403 McrA, Restriction endonuclease Defense mechanisms 118469491 Common - RNA polymerase sigma-70 factor MSMEG_6931 167 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118469246 Common - ABC polar amino acid transporter, inner membrane subunit MSMEG_1613 174 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 118468620 Pathogen - hypothetical protein MSMEG_2312 1 None None None 118471257 Common - carboxylate-amine ligase Nfa27300 MSMEG_5590 60 COG2170 COG2170, Uncharacterized conserved protein Function unknown 118472961 Common - alkanal monooxygenase alpha chain MSMEG_5029 113 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118469181 Pathogen - hypothetical protein MSMEG_3865 1 None None None 118471385 Common - hypothetical protein MSMEG_5547 27 COG1289 COG1289, Predicted membrane protein Function unknown 118469535 Common - hydrolase, alpha/beta hydrolase fold family protein MSMEG_6831 99 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118470335 Common - extracellular solute-binding protein, family protein 5, putative MSMEG_0643 179 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 118471647 Common - nitrate reductase NarB MSMEG_2837 193 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 118468359 Common - dehydrogenase/reductase SDR family protein member 10 MSMEG_2535 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118473268 Common - base excision DNA repair protein, HhH-GPD family protein MSMEG_5156 11 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 118468478 Common tesB acyl-CoA thioesterase II MSMEG_2938 77 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 118473926 Pathogen - hypothetical protein MSMEG_4445 1 None None None 118472159 Common - acyl-CoA synthetase MSMEG_3465 183 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118468908 Common - pirin domain protein MSMEG_0049 143 COG1741 COG1741, Pirin-related protein General function prediction only 118472567 Common - hypothetical protein MSMEG_4723 79 COG0433 COG0433, Predicted ATPase General function prediction only 118473114 Common - NADP oxidoreductase, coenzyme f420-dependent:6-phosphogluconate dehydrogenase, nad-binding, putative MSMEG_6884 13 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 118471188 Common - Tat-translocated enzyme MSMEG_5420 43 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 118468765 Common - acetyl-CoA synthetase MSMEG_0718 220 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 118468762 Common oppD ABC transporter, ATP-binding protein OppD MSMEG_4997 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 118468271 Common - rifampin ADP-ribosyl transferase MSMEG_1224 2 None None None 118470773 Common - hypothetical protein MSMEG_6749 1 None None None 118473042 Common - transcription factor WhiB family protein MSMEG_0051 1 None None None 118471668 Common - GntT protein, putative MSMEG_2022 81 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 118469799 Common - hypothetical protein MSMEG_3204 3 None None None 118468549 Common - alpha/beta hydrolase fold MSMEG_1587 9 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118473614 Common - hypothetical protein MSMEG_1225 6 None None None 118471660 Common - formamidase MSMEG_0484 66 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 118467399 Pathogen - hypothetical protein MSMEG_2126 1 None None None 118469174 Common - glycosyl transferase MSMEG_1113 178 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 118473226 Common - hypothetical protein MSMEG_6728 7 None None None 118470648 Common - probable antibiotic-transport integral membrane leucine and alanine and valine rich protein abc transporter MSMEG_1504 6 None None None 118471584 Common - hypothetical protein MSMEG_6613 4 None None None 118472902 Common - CBS domain protein MSMEG_4495 218 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 118469761 Common - choline dehydrogenase MSMEG_5305 88 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 118467392 Common pepN aminopeptidase N MSMEG_4690 166 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 118470203 Common - phospho-2-dehydro-3-heoxyheptonate aldolase MSMEG_2799 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 118471321 Common - hypothetical protein MSMEG_5527 1 None None None 118473538 Common - RNA polymerase sigma-70 factor MSMEG_5214 149 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118468627 Common - hypothetical protein MSMEG_0853 2 COG0490 COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels Inorganic ion transport and metabolism 118472154 Common purU formyltetrahydrofolate deformylase MSMEG_2200 215 COG0788 PurU, Formyltetrahydrofolate hydrolase Nucleotide transport and metabolism 118473794 Common - Na+/H+ antiporter MSMEG_0764 81 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 118467948 Common - hypothetical protein MSMEG_3661 2 None None None 118469392 Pathogen - hypothetical protein MSMEG_5665 1 None None None 118470391 Common - IS6120, transposase MSMEG_4159 83 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 118468856 Common - hypothetical protein MSMEG_3074 10 None None None 118470123 Common - protein phosphatase 2C MSMEG_0033 131 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 118473962 Common - enoyl-CoA hydratase MSMEG_1388 164 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118467454 Common - hypothetical protein MSMEG_0630 9 COG4424 COG4424, Uncharacterized protein conserved in bacteria Function unknown 118468108 Common - enoyl-CoA hydratase/isomerase MSMEG_4299 182 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118468537 Pathogen - hypothetical protein MSMEG_5716 1 COG4875 COG4875, Uncharacterized protein conserved in bacteria with a cystatin-like fold Function unknown 118471542 Common - hypothetical protein MSMEG_4161 1 None None None 118472539 Common - hydrogen:quinone oxidoreductase MSMEG_2719 88 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 118467610 Common - transcriptional regulatory protein PadR- MSMEG_0469 92 COG1846 MarR, Transcriptional regulators Transcription 118472244 Common - hypothetical protein MSMEG_6163 1 None None None 118468106 Common - hypothetical protein MSMEG_2154 13 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 118472400 Common - alpha/beta hydrolase fold MSMEG_0460 52 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118468533 Common - DNA-damage-inducible protein MSMEG_2742 1 None None None 118473194 Common - alpha/beta hydrolase MSMEG_4450 29 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 118471196 Common - hypothetical protein MSMEG_0794 10 None None None 118470674 Common - 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase MSMEG_1630 234 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118472369 Common - senescence marker protein-30 MSMEG_6378 69 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 118472462 Common - ISMsm1, transposase orfB MSMEG_1730 140 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 118471475 Pathogen - hypothetical protein MSMEG_2533 1 None None None 118467944 Common - probable serine/threonine-protein kinase PknB MSMEG_5437 137 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 118468841 Common putP sodium/proline symporter MSMEG_5303 161 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 118472322 Common - transcriptional regulator, LysR family protein MSMEG_1391 160 COG0583 LysR, Transcriptional regulator Transcription 118471840 Common - virulence factor Mce family protein MSMEG_5898 37 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118468493 Common - transcriptional regulator, TetR family protein MSMEG_2193 120 COG1309 AcrR, Transcriptional regulator Transcription 118468220 Common - hypothetical protein MSMEG_3435 2 None None None 118467688 Common - hypothetical protein MSMEG_2573 18 COG2343 COG2343, Uncharacterized protein conserved in bacteria Function unknown 118469103 Common - RsbW protein MSMEG_1787 3 None None None 118471958 Common - hypothetical protein MSMEG_6847 9 None None None 118468589 Common - isoniazid inductible protein IniC MSMEG_0698 25 COG0699 COG0699, Predicted GTPases (dynamin-related) General function prediction only 118469595 Common nuoH NADH dehydrogenase subunit H MSMEG_2056 190 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 118468332 Common - NADP-dependent fatty aldehyde dehydrogenase MSMEG_6134 182 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118473738 Common - response regulator receiver domain protein MSMEG_3298 49 COG3558 COG3558, Uncharacterized protein conserved in bacteria Function unknown 118468261 Pathogen - hypothetical protein MSMEG_4069 1 None None None 118471025 Common sdaA L-serine ammonia-lyase MSMEG_3440 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 118468981 Common - hypothetical protein MSMEG_0723 1 None None None 118468021 Common - HIT family protein MSMEG_5028 231 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 118469107 Common - hypothetical protein MSMEG_4447 7 None None None 118471625 Common - enoyl-CoA hydratase MSMEG_5639 169 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118472879 Common ychF translation-associated GTPase MSMEG_5222 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 118471426 Common - AttM/AiiB family protein MSMEG_3925 68 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 118471079 Common - transcriptional regulator, TetR family protein MSMEG_2153 69 COG1309 AcrR, Transcriptional regulator Transcription 118472028 Common - Glycerophosphoryl diester phosphodiesterase family protein MSMEG_6423 169 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 118469975 Common - AsnC-family protein transcriptional regulator MSMEG_1415 139 COG1522 Lrp, Transcriptional regulators Transcription 118472270 Common proS prolyl-tRNA synthetase MSMEG_2621 222 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 118470388 Pathogen - acyl-CoA dehydrogenase MSMEG_4113 1 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118469675 Common - hypothetical protein MSMEG_5229 5 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 118471121 Common - methyltransferase type 11 MSMEG_2285 176 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118470440 Common - hypothetical protein MSMEG_4681 4 COG5164 SPT5, Transcription elongation factor Transcription 118473084 Common - transcriptional regulator, AraC family protein MSMEG_5465 36 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 118468930 Common - aspartate transaminase MSMEG_6286 46 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 118471201 Common - putative acyl-CoA dehydrogenase MSMEG_2205 164 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118467971 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding MSMEG_0684 117 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 118471784 Common - probable conserved membrane protein MSMEG_1534 7 None None None 118467976 Common - transmembrane transport protein MSMEG_0170 89 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118471371 Common - gp15 protein MSMEG_2146 10 COG5280 COG5280, Phage-related minor tail protein Function unknown 118467675 Common - iron(III)-transport system permease protein SfuB MSMEG_3635 179 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 118470421 Common - hypothetical protein MSMEG_5614 27 COG3246 COG3246, Uncharacterized conserved protein Function unknown 118473055 Common - hypothetical protein MSMEG_6579 1 None None None 118467746 Common - hypothetical ABC transporter ATP-binding protein YphE MSMEG_4000 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 118469683 Common - chorismate mutase MSMEG_5536 10 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 118470492 Common - two-component sensor kinase MSMEG_5304 200 COG3290 CitA, Signal transduction histidine kinase regulating citrate/malate metabolism Signal transduction mechanisms 118472223 Common - acyl-CoA dehydrogenase, short-chain specific, putative MSMEG_0323 134 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473164 Common - hypothetical protein MSMEG_3323 3 None None None 118467547 Common - putative conserved membrane protein MSMEG_4534 3 None None None 118472251 Common - secreted protein MSMEG_6218 10 None None None 118467572 Common - transcriptional regulator, TetR family protein, putative MSMEG_6555 4 None None None 118473389 Common - Fe-S metabolism associated SufE MSMEG_1808 53 COG2166 COG2166, SufE protein probably involved in Fe-S center assembly General function prediction only 118470435 Common - metallo-beta-lactamase family protein MSMEG_6679 82 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 118467702 Common - enoyl-CoA hydratase MSMEG_5277 189 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118473235 Common - carbohydrate kinase, PfkB, putative MSMEG_4647 30 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 118467996 Common - glycerol-3-phosphate acyltransferase MSMEG_4703 48 COG2937 PlsB, Glycerol-3-phosphate O-acyltransferase Lipid metabolism 118471804 Common - hypothetical protein MSMEG_3841 79 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118468558 Common - PhoH family protein MSMEG_4497 199 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 118470784 Common - hypothetical protein MSMEG_2864 2 None None None 118472834 Common - hypothetical protein MSMEG_1456 53 COG3835 CdaR, Sugar diacid utilization regulator Transcription / Signal transduction mechanisms 118471016 Common - ABC transporter ATP-binding protein MSMEG_2979 249 COG4674 COG4674, Uncharacterized ABC-type transport system, ATPase component General function prediction only 118470711 Common - ferric uptake regulation protein MSMEG_4487 187 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 118471442 Common - hypothetical protein MSMEG_2500 8 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 118469970 Common - modulator of DNA gyrase MSMEG_4464 166 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 118469571 Common - hypothetical protein MSMEG_0840 1 None None None 118468645 Common - glucose-1-dehydrogenase MSMEG_4440 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118472065 Common - hypothetical protein MSMEG_4245 9 None None None 118472847 Common - endo-type 6-aminohexanoate oligomer hydrolase MSMEG_4908 51 COG3191 DmpA, L-aminopeptidase/D-esterase Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118470946 Common - short chain dehydrogenase MSMEG_5931 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118473838 Common ectC L-ectoine synthase MSMEG_3899 35 None None None 118471086 Common - pantothenate kinase MSMEG_6096 108 COG1521 COG1521, Putative transcriptional regulator, homolog of Bvg accessory factor Transcription 118474014 Common - CBS domain protein MSMEG_4564 154 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 118472382 Common - hypothetical protein MSMEG_3224 7 None None None 118472375 Pathogen - hypothetical protein MSMEG_0945 1 None None None 118470941 Common - serine esterase, cutinase family protein MSMEG_0194 4 None None None 118472163 Common - transcriptional regulator, TetR family protein MSMEG_2239 28 COG1309 AcrR, Transcriptional regulator Transcription 118472055 Common kgd alpha-ketoglutarate decarboxylase MSMEG_5049 179 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 118471140 Common - hydrolase, alpha/beta fold family protein MSMEG_1998 80 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118472541 Common - hypothetical protein MSMEG_3868 3 None None None 118471443 Common - aspartate kinase MSMEG_6257 233 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 118467533 Common - hypothetical protein MSMEG_3951 25 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 118468002 Common - cutinase MSMEG_4465 3 None None None 118473890 Common - methyltransferase MSMEG_6572 74 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118469331 Common - secreted protein MSMEG_6180 8 None None None 118469159 Common - Rieske [2Fe-2S] domain protein MSMEG_0293 75 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 118469952 Common - hypothetical protein MSMEG_0738 1 None None None 118470792 Common - tartrate dehydrogenase MSMEG_1986 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 118469708 Common - 4-coumarate:CoA ligase MSMEG_2360 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118470906 Common - GntR-family protein transcriptional regulator MSMEG_0166 139 COG1802 GntR, Transcriptional regulators Transcription 118473892 Common - LprE protein MSMEG_5043 2 None None None 118467637 Common - putative transcriptional regulator MSMEG_4953 40 COG1309 AcrR, Transcriptional regulator Transcription 118469314 Common - S-(hydroxymethyl)glutathione dehydrogenase MSMEG_0671 206 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 118473918 Common - hypothetical protein MSMEG_2110 3 None None None 118471164 Common - molybdopterin-guanine dinucleotide biosynthesis protein A MSMEG_4644 13 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 118471059 Common - membrane transport protein MSMEG_5674 129 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118471272 Common - hypothetical protein MSMEG_5586 24 COG3804 COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase Function unknown 118468846 Common - hydrolase, carbon-nitrogen family protein MSMEG_5655 187 COG0388 COG0388, Predicted amidohydrolase General function prediction only 118468784 Common - membrane protein MSMEG_6386 5 None None None 118470810 Common - amino acid permease MSMEG_2772 43 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118468381 Common - short chain dehydrogenase MSMEG_0530 205 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118468915 Common - glyoxalase family protein MSMEG_0884 65 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 118467496 Common - probable cytochrome c oxidase polypeptide 4 MSMEG_4267 18 None None None 118473138 Common - hypothetical protein MSMEG_5099 2 None None None 118472932 Common - mce related protein MSMEG_1143 6 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118469071 Common - hypothetical protein MSMEG_3910 8 None None None 118467621 Common - enoyl-CoA hydratase/isomerase family protein MSMEG_2219 179 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118473247 Common - dihydrofolate reductase MSMEG_0308 47 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 118472586 Pathogen - hypothetical protein MSMEG_3643 1 None None None 118468284 Common - hypothetical protein MSMEG_6901 9 None None None 118469304 Common - DNA binding domain, excisionase family protein MSMEG_0944 19 None None None 118469467 Common - hypothetical protein MSMEG_6428 3 None None None 118470998 Common - short chain dehydrogenase MSMEG_1157 232 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118468874 Common - competence damage-inducible protein A MSMEG_3512 214 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 118470069 Common - acyl-CoA dehydrogenase MSMEG_6585 113 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118468514 Pathogen - hypothetical protein MSMEG_5320 1 None None None 118468831 Common uppS undecaprenyl diphosphate synthase MSMEG_4490 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 118470053 Common rfbA glucose-1-phosphate thymidylyltransferase MSMEG_5983 232 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 118472673 Pathogen - hypothetical protein MSMEG_5507 1 None None None 118469483 Common - hypothetical protein MSMEG_3514 1 None None None 118468836 Common nadD nicotinate (nicotinamide) nucleotide adenylyltransferase MSMEG_4581 149 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 118470534 Common - protozoan/cyanobacterial globin family protein MSMEG_4695 63 COG2346 COG2346, Truncated hemoglobins General function prediction only 118470198 Pathogen - hypothetical protein MSMEG_3916 1 None None None 118473274 Common - hypothetical protein MSMEG_6247 65 COG4301 COG4301, Uncharacterized conserved protein Function unknown 118467845 Common - alkanesulfonate monooxygenase MSMEG_4539 80 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118469261 Common - glycosyl transferase, group 1, putative MSMEG_5964 83 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 118469079 Common - probable conserved transmembrane protein MSMEG_6424 3 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 118470526 Common - hypothetical protein MSMEG_2790 1 None None None 118473679 Common - ABC transporter membrane protein MSMEG_4657 115 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 118471636 Common - para-nitrobenzyl esterase MSMEG_3002 56 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 118472475 Common - hypothetical protein MSMEG_4428 4 None None None 118468268 Common - enoyl-CoA hydratase MSMEG_6353 172 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118469302 Common - hypothetical protein MSMEG_5514 1 None None None 118470540 Common - transcriptional regulator, MarR family protein MSMEG_6361 28 COG1846 MarR, Transcriptional regulators Transcription 118468814 Common - ABC1 family protein MSMEG_1954 184 COG0661 AarF, Predicted unusual protein kinase General function prediction only 118473722 Common - polyphosphate kinase 2 superfamily protein MSMEG_0915 127 COG2326 COG2326, Uncharacterized conserved protein Function unknown 118469449 Common - ABC transporter, nucleotide binding/ATPase protein MSMEG_0556 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 118473316 Common pimE mannosyltransferase MSMEG_5149 12 None None None 118471099 Common - cell filamentation protein MSMEG_2181 29 COG2184 Fic, Protein involved in cell division Cell division and chromosome partitioning 118469819 Common - beta-lactamase MSMEG_3162 59 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 118473420 Common - possible lysine decarboxylase superfamily protein MSMEG_4135 114 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 118470981 Common pgl 6-phosphogluconolactonase MSMEG_3099 95 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 118469981 Common - pyridoxamine 5'-phosphate oxidase family protein MSMEG_5717 4 None None None 118470484 Common - major facilitator superfamily protein MFS_1 MSMEG_3705 39 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118473977 Common - amino acid permease MSMEG_1118 134 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118471068 Common hydA dihydropyrimidinase MSMEG_3996 192 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 118468773 Common - hypothetical protein MSMEG_0967 3 None None None 118467782 Common - Rieske [2Fe-2S] domain protein MSMEG_5925 68 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 118473628 Common - hypothetical protein MSMEG_5313 1 None None None 118469061 Common murC UDP-N-acetylmuramate--L-alanine ligase MSMEG_4226 208 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 118471128 Common - mce related protein MSMEG_1148 6 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118471486 Common - alkylhydroperoxide reductase MSMEG_4891 224 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 118469515 Common - hypothetical protein MSMEG_6419 8 None None None 118472045 Common - NfnB protein MSMEG_6505 63 COG0778 NfnB, Nitroreductase Energy production and conversion 118470952 Common - thiamine biosynthesis protein ThiC MSMEG_0149 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 118472747 Common - 14 kDa antigen MSMEG_3932 136 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 118473182 Common - oxidoreductase MSMEG_5719 60 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118472075 Common - putative glutamine-binding periplasmic protein MSMEG_6692 126 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 118471026 Common galU UTP-glucose-1-phosphate uridylyltransferase MSMEG_5471 219 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 118472414 Common - transcriptional regulator MSMEG_6421 57 COG1316 LytR, Transcriptional regulator Transcription 118469887 Common - transcriptional regulator, LysR family protein MSMEG_6674 97 COG0583 LysR, Transcriptional regulator Transcription 118470158 Common - anaerobic dehydrogenase, typically MSMEG_2237 178 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 118472820 Common acpS 4'-phosphopantetheinyl transferase MSMEG_4756 8 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 118472080 Common - ribose transport ATP-binding protein RbsA MSMEG_4170 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 118468890 Common thrC threonine synthase MSMEG_4956 171 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 118473392 Common - nitrilotriacetate monooxygenase component A MSMEG_6641 66 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118472783 Pathogen - hypothetical protein MSMEG_6355 1 None None None 118472766 Common - phytoene dehydrogenase MSMEG_2347 71 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118468823 Common - peptidyl-prolyl cis-trans isomerase, cyclophilin-type MSMEG_2974 75 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 118472455 Pathogen - hypothetical protein MSMEG_1643 1 COG1520 COG1520, FOG: WD40-like repeat Function unknown 118469158 Common hypF [NiFe] hydrogenase maturation protein HypF MSMEG_2273 114 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 118472429 Common - acyl-CoA dehydrogenase-family protein MSMEG_4391 123 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118470376 Common - xylose transport system permease protein XylH MSMEG_6018 100 COG4214 XylH, ABC-type xylose transport system, permease component Carbohydrate transport and metabolism 118472183 Common - protein-tyrosine kinase, putative MSMEG_5955 13 COG3944 COG3944, Capsular polysaccharide biosynthesis protein Cell envelope biogenesis, outer membrane 118469048 Common - rifampin ADP-ribosyl transferase MSMEG_1221 11 None None None 118473766 Common - hypothetical protein MSMEG_2450 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 118472331 Common - peptidase, M50B family protein MSMEG_0756 54 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 118472407 Common - amidohydrolase family protein MSMEG_0883 75 COG3653 COG3653, N-acyl-D-aspartate/D-glutamate deacylase Secondary metabolites biosynthesis, transport, and catabolism 118467484 Common - hypothetical protein MSMEG_1013 38 COG4637 COG4637, Predicted ATPase General function prediction only 118467852 Common glmM phosphoglucosamine mutase MSMEG_1559 234 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 118471050 Common - ABC transporter, permease protein UspA MSMEG_4466 149 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 118469939 Common - glutamyl-tRNA(Gln) amidotransferase subunit A MSMEG_4062 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 118469268 Common - hydrolase, alpha/beta hydrolase fold family protein MSMEG_3508 56 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118468037 Common - ribose transport system permease protein RbsC MSMEG_1710 112 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 118473307 Common - hypothetical protein MSMEG_4909 11 None None None 118470042 Common - 5-carboxymethyl-2-hydroxymuconate delta-isomerase MSMEG_1321 157 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 118469862 Common - polysaccharide biosynthesis protein MSMEG_5968 70 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 118471878 Common - DNA-binding response regulator, LuxR family protein MSMEG_0105 211 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118470921 Common - Transposase IS116/IS110/IS902 family protein MSMEG_4081 31 None None None 118471656 Common - alcohol dehydrogenase, iron-containing MSMEG_6242 167 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 118467865 Common rph ribonuclease PH MSMEG_4901 179 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 118472289 Common - transporter ATPase MSMEG_2459 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 118471104 Pathogen - hypothetical protein MSMEG_5552 1 None None None 118473984 Common - major facilitator superfamily protein, putative MSMEG_0577 28 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118472520 Common - cytochrome P450-terp MSMEG_1429 78 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118468726 Pathogen - hypothetical protein MSMEG_1887 1 None None None 118468097 Common - putative cytochrome P450 135B1 MSMEG_6478 86 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118470306 Common menB naphthoate synthase MSMEG_4114 174 COG0447 MenB, Dihydroxynaphthoic acid synthase Coenzyme metabolism 118471401 Common - CBS domain protein MSMEG_3638 201 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 118472362 Common - glycerol dehydratase large subunit MSMEG_1547 13 COG4909 PduC, Propanediol dehydratase, large subunit Secondary metabolites biosynthesis, transport, and catabolism 118470138 Common - probable transcriptional regulatory protein MSMEG_1029 39 COG1309 AcrR, Transcriptional regulator Transcription 118469152 Common - hypothetical protein MSMEG_3015 1 None None None 118471974 Common - MaoC like domain protein MSMEG_1993 31 COG3777 COG3777, Uncharacterized conserved protein Function unknown 118471161 Common - hypothetical protein MSMEG_0163 2 None None None 118472758 Common - transcriptional regulatory protein MSMEG_0509 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 118471825 Pathogen - hypothetical protein MSMEG_5770 1 None None None 118468215 Pathogen - hypothetical protein MSMEG_4052 1 None None None 118472033 Common - putative oxidoreductase YdbC MSMEG_4686 156 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 118473410 Common - acyl-CoA synthetase MSMEG_2241 200 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118470908 Pathogen - hypothetical protein MSMEG_0494 1 None None None 118468347 Common - hypothetical protein MSMEG_4770 5 None None None 118468396 Common - L-lactate permease MSMEG_6826 104 COG1620 LldP, L-lactate permease Energy production and conversion 118470691 Common mdcH malonate decarboxylase, epsilon subunit MSMEG_6629 131 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 118469085 Common - hypothetical protein MSMEG_3727 2 None None None 118471500 Common cobU Cobinamide kinase / cobinamide phosphate guanyltransferase MSMEG_4274 126 COG2087 CobU, Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase Coenzyme metabolism 118467916 Common - ferredoxin-dependent glutamate synthase 1 MSMEG_3225 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 118473712 Common - hypothetical protein MSMEG_6493 2 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 118468119 Common - methyltransferase type 12 MSMEG_2067 48 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 118471088 Common tuf elongation factor Tu MSMEG_1401 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 118467509 Common - transcriptional regulatory protein MSMEG_4053 52 COG3899 COG3899, Predicted ATPase General function prediction only 118474049 Common - major facilitator superfamily protein MFS_1, putative MSMEG_4147 7 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 118472934 Common - sulfate/thiosulfate import ATP-binding protein CysA MSMEG_6671 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 118472548 Common - hypothetical protein MSMEG_6248 39 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 118469755 Common - HpcH/HpaI aldolase/citrate lyase family protein MSMEG_4713 107 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 118471319 Common - secreted protein MSMEG_0431 34 COG2138 COG2138, Uncharacterized conserved protein Function unknown 118468077 Common - acyl-CoA synthetase MSMEG_4952 217 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118469356 Common - acetyl-CoA acetyltransferase MSMEG_1896 168 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118467577 Common - hypothetical protein MSMEG_5930 22 None None None 118468149 Common - 3-hydroxybutyryl-CoA dehydratase MSMEG_4119 187 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118470262 Common - molybdenum cofactor synthesis domain protein MSMEG_5702 189 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 118471754 Common - putative transcriptional regulator MSMEG_4205 30 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118470360 Common - ABC transporter, ATP-binding protein MSMEG_4541 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 118468457 Common - hypothetical protein MSMEG_4933 9 None None None 118469371 Common - monooxygenase MSMEG_5519 82 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118471396 Common bioB biotin synthase MSMEG_3194 183 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 118469231 Common - proteasome component MSMEG_3897 16 None None None 118474042 Common - trans-2-enoyl-CoA reductase MSMEG_2155 105 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118470490 Common - putative aminotransferase MSMEG_0277 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 118467872 Pathogen - hypothetical protein MSMEG_0648 1 None None None 118470554 Common - muconate cycloisomerase MSMEG_1910 136 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 118474004 Common - MmpS4 protein MSMEG_0462 1 None None None 118471706 Common - integral membrane transport protein MSMEG_3985 178 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118468816 Common - hypothetical protein MSMEG_5298 1 None None None 118473272 Common - hypothetical protein MSMEG_1518 1 None None None 118472497 Common - hypothetical protein MSMEG_6779 9 None None None 118468977 Common - RNA methyltransferase, TrmH family protein MSMEG_3790 149 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 118468801 Pathogen - hypothetical protein MSMEG_1300 1 None None None 118470669 Common - ABC transporter ATP-binding protein MSMEG_2978 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 118472655 Common - hypothetical protein MSMEG_5953 2 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 118471502 Common - hypothetical protein MSMEG_0416 1 None None None 118473506 Common - transcriptional regulator, TetR family protein MSMEG_2043 32 COG1309 AcrR, Transcriptional regulator Transcription 118470895 Common - probable cutinase Cut3 MSMEG_2474 3 COG5153 CVT17, Putative lipase essential for disintegration of autophagic bodies inside the vacuole Intracellular trafficking and secretion / Lipid metabolism 118470140 Common - N-acetylmuramoyl-L-alanine amidase MSMEG_6935 88 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 118473801 Common purT phosphoribosylglycinamide formyltransferase 2 MSMEG_5274 204 COG0027 PurT, Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) Nucleotide transport and metabolism 118469271 Common - two-component system response regulator MSMEG_2064 11 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 118469125 Common - NADH dehydrogenase subunit E MSMEG_2059 156 COG1905 NuoE, NADH:ubiquinone oxidoreductase 24 kD subunit Energy production and conversion 118467934 Common - MmpL4 protein MSMEG_3496 47 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 118472697 Common - putative acyl-CoA dehydrogenase MSMEG_2081 149 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472454 Common - nitroreductase family protein MSMEG_1635 18 COG0778 NfnB, Nitroreductase Energy production and conversion 118473465 Common - integral membrane protein MSMEG_6732 8 None None None 118467660 Common - integral membrane protein MSMEG_4988 17 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 118471953 Common - Erp protein MSMEG_6405 1 COG5164 SPT5, Transcription elongation factor Transcription 118468851 Pathogen - hypothetical protein MSMEG_1948 1 None None None 118467569 Common - hypothetical protein MSMEG_2874 4 None None None 118470149 Common - transcriptional regulator MSMEG_5673 42 COG1309 AcrR, Transcriptional regulator Transcription 118469744 Common - hydrolase, NUDIX family protein MSMEG_0790 14 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 118472727 Common - hypothetical protein MSMEG_4029 6 COG5516 COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding General function prediction only 118473086 Common - hypothetical protein MSMEG_5013 27 COG2013 COG2013, Uncharacterized conserved protein Function unknown 118468866 Common folB dihydroneopterin aldolase MSMEG_6102 124 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 118469361 Common - TetR family protein transcriptional regulatory protein MSMEG_1500 13 COG1309 AcrR, Transcriptional regulator Transcription 118472512 Common - hypothetical protein MSMEG_3322 2 None None None 118470182 Common - dgpf protein MSMEG_1100 40 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 118472274 Common - putative acyl-CoA dehydrogenase MSMEG_4874 143 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118469296 Common - nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase MSMEG_1120 49 COG0388 COG0388, Predicted amidohydrolase General function prediction only 118470914 Common - probable monooxygenase MSMEG_2567 63 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 118471411 Common - putative acyl-CoA dehydrogenase MSMEG_2992 139 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472648 Common - helix-turn-helix domain protein MSMEG_0609 41 COG1396 HipB, Predicted transcriptional regulators Transcription 118470590 Common - hypothetical protein MSMEG_1772 5 None None None 118470441 Common - isonitrile hydratase, putative MSMEG_3366 104 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 118471550 Common - periplasmic sugar-binding proteins MSMEG_3598 109 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118473210 Common - MarR-family protein regulatory protein MSMEG_6824 39 COG1846 MarR, Transcriptional regulators Transcription 118473280 Common pqqE pyrroloquinoline quinone biosynthesis protein PqqE MSMEG_3721 166 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 118472359 Common - putative sugar ABC transporter ATP-binding protein MSMEG_3269 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 118468878 Common - hypothetical protein MSMEG_2782 35 COG3253 COG3253, Uncharacterized conserved protein Function unknown 118471304 Common - hypothetical protein MSMEG_0921 3 None None None 118467795 Common - hypothetical protein MSMEG_2940 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 118472148 Common - hypothetical protein MSMEG_5855 3 None None None 118470639 Common - epoxide hydrolase 1 MSMEG_0182 42 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118471737 Common - ABC transporter, ATP-binding protein MSMEG_2524 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 118471473 Common - ABC transporter oligopeptide binding protein MSMEG_4385 205 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 118472522 Common - 2,2-dialkylglycine decarboxylase MSMEG_6842 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 118468754 Common - 3-hydroxyacyl-CoA dehydrogenase type-2 MSMEG_2279 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118468631 Common - molybdopterin biosynthesis protein MoeA MSMEG_0862 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 118470599 Common - glutamate-ammonia-ligase adenylyltransferase MSMEG_4293 119 COG1391 GlnE, Glutamine synthetase adenylyltransferase Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms 118469754 Common - sarcosine oxidase subunit beta, putative MSMEG_0665 87 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 118467951 Pathogen - hypothetical protein MSMEG_4438 1 None None None 118471244 Common - serine/threonine-protein kinase PknE, putative MSMEG_1215 9 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 118471198 Common - UsfY protein MSMEG_1769 1 None None None 118469903 Common aroB 3-dehydroquinate synthase MSMEG_3033 205 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 118468481 Common secE preprotein translocase subunit SecE MSMEG_1344 9 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 118467887 Common - hypothetical protein MSMEG_1371 49 COG1482 ManA, Phosphomannose isomerase Carbohydrate transport and metabolism 118471617 Common - putative transcriptional regulator family protein MSMEG_3013 96 COG1733 COG1733, Predicted transcriptional regulators Transcription 118469226 Common - chloramphenicol resistance protein MSMEG_6245 102 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118470839 Common - coenzyme A transferase, subunit A MSMEG_6002 55 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 118467956 Common glnA glutamine synthetase, type I MSMEG_4290 224 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 118469280 Common - pyruvate dehydrogenase MSMEG_5593 222 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 118470111 Pathogen - hypothetical protein MSMEG_4359 1 None None None 118470706 Common cbbQ CbbQ protein MSMEG_6809 81 COG0714 COG0714, MoxR-like ATPases General function prediction only 118471299 Common - integral membrane protein of the ABC-type Nat permease for neutral amino acids NatD MSMEG_6879 150 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 118473587 Common - endoglucanase A MSMEG_6752 17 COG5297 CelA, Cellobiohydrolase A (1,4-beta-cellobiosidase A) Carbohydrate transport and metabolism 118471569 Common - muconolactone delta-isomerase 1 MSMEG_1912 24 COG4829 CatC1, Muconolactone delta-isomerase Secondary metabolites biosynthesis, transport, and catabolism 118468180 Common - hypothetical protein MSMEG_4252 4 None None None 118468230 Common - transcriptional regulator, TetR family protein MSMEG_0612 8 COG1309 AcrR, Transcriptional regulator Transcription 118468156 Common - transporter, major facilitator family protein MSMEG_6922 9 None None None 118470169 Common - transposase MSMEG_4088 48 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 118469853 Common - transcriptional regulator, TetR family protein MSMEG_6807 139 COG1309 AcrR, Transcriptional regulator Transcription 118468858 Common - acyl-CoA dehydrogenase, C- domain protein MSMEG_0198 78 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118469012 Common - nitrate/sulfonate/bicarbonate ABC transporter ATPase subunit MSMEG_6496 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 118467731 Common gcvH glycine cleavage system protein H MSMEG_3648 186 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 118470856 Common pyk pyruvate kinase MSMEG_3227 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 118471023 Common trmD tRNA (guanine-N(1)-)-methyltransferase MSMEG_2438 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 118473971 Common - glyoxylate reductase MSMEG_2550 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 118471136 Common - hypothetical protein MSMEG_5254 1 None None None 118468716 Common - aminoglycoside phosphotransferase MSMEG_2286 59 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 118470060 Common - RDD family protein MSMEG_5266 11 COG1714 COG1714, Predicted membrane protein/domain Function unknown 118470301 Common - transcriptional modulator of MazE MSMEG_4448 37 COG2337 MazF, Growth inhibitor Signal transduction mechanisms 118470160 Common - putative esterase MSMEG_6838 22 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118471885 Common - transcriptional regulator, GntR family protein MSMEG_4042 127 COG1802 GntR, Transcriptional regulators Transcription 118468330 Common - probable sugar ABC transporter, substrate-binding protein, putative MSMEG_0553 80 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118471673 Common - dehydrogenase MSMEG_0737 236 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118471533 Common - HicB family protein MSMEG_5186 11 COG4226 HicB, Uncharacterized protein encoded in hypervariable junctions of pilus gene clusters Function unknown 118471693 Common - [2Fe-2S] binding domain protein MSMEG_5883 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 118469880 Common - dihydrodipicolinate synthase MSMEG_0877 234 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 118472298 Common - hypothetical protein MSMEG_5722 2 None None None 118470327 Common - periplasmic sensor signal transduction histidine kinase MSMEG_1637 31 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 118471768 Common - oxidoreductase MSMEG_5189 68 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118469994 Common - dolichyl-phosphate-mannose-protein mannosyltransferase MSMEG_5447 33 COG1928 PMT1, Dolichyl-phosphate-mannose--protein O-mannosyl transferase Posttranslational modification, protein turnover, chaperones 118471903 Common - transcriptional regulator MSMEG_1178 67 COG1737 RpiR, Transcriptional regulators Transcription 118472559 Common - sorbitol utilization protein SOU2 MSMEG_3604 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471404 Common - Transcription factor WhiB MSMEG_1919 19 None None None 118469430 Common - putative transcriptional regulator, TetR family protein MSMEG_2049 15 COG1309 AcrR, Transcriptional regulator Transcription 118473772 Common - hypothetical protein MSMEG_2756 2 None None None 118468647 Common - possible inv protein MSMEG_3477 53 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 118470850 Common - alkylhydroperoxidase AhpD core MSMEG_5319 72 COG2128 COG2128, Uncharacterized conserved protein Function unknown 118472232 Common - glutamate--cysteine ligase MSMEG_6250 54 COG3572 GshA, Gamma-glutamylcysteine synthetase Coenzyme metabolism 118468599 Common - cytochrome c oxidase subunit III family protein MSMEG_6530 59 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 118470545 Common - succinic semialdehyde dehydrogenase MSMEG_0582 221 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118469488 Common - transcriptional regulator, AraC family protein MSMEG_3365 142 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 118470162 Common rpsF 30S ribosomal protein S6 MSMEG_6897 191 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 118473196 Common rplA 50S ribosomal protein L1 MSMEG_1347 243 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 118473395 Common - transcriptional regulator, RpiR family protein MSMEG_0192 169 COG1737 RpiR, Transcriptional regulators Transcription 118469516 Common - dihydrokaempferol 4-reductase MSMEG_2247 120 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118469894 Common - putative ribosylglycohydrolase MSMEG_1272 35 COG1397 DraG, ADP-ribosylglycohydrolase Posttranslational modification, protein turnover, chaperones 118467974 Common sufD FeS assembly protein SufD MSMEG_3123 170 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 118472781 Common - Soj family protein MSMEG_6939 200 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 118471916 Common - hypothetical protein MSMEG_5708 1 None None None 118472752 Common - hypothetical protein MSMEG_1844 54 COG2323 COG2323, Predicted membrane protein Function unknown 118472320 Common - hypothetical protein MSMEG_3657 74 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 118472370 Pathogen - hypothetical protein MSMEG_3617 1 None None None 118469436 Common - serine protease MSMEG_6183 101 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 118473133 Common - putative carbon monoxide dehydrogenase subunit G MSMEG_5881 38 COG3427 COG3427, Uncharacterized conserved protein Function unknown 118473401 Pathogen - hypothetical protein MSMEG_1230 1 COG2149 COG2149, Predicted membrane protein Function unknown 118468179 Common - hypothetical protein MSMEG_4186 22 COG2047 COG2047, Uncharacterized protein (ATP-grasp superfamily) General function prediction only 118473816 Common - dihydrodipicolinate synthetase MSMEG_1156 90 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 118470933 Common - Transposase IS116/IS110/IS902 family protein MSMEG_3984 31 None None None 118470308 Common - alpha-glucan phosphorylase family protein MSMEG_4915 141 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 118469859 Common - peptidase, M24 family protein MSMEG_4853 81 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 118469536 Common - hypothetical protein MSMEG_2508 94 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 118467693 Common - CAIB/BAIF family protein MSMEG_2023 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118471298 Pathogen - hypothetical protein MSMEG_3794 1 None None None 118469289 Common - hypothetical protein MSMEG_6655 3 None None None 118469407 Common - transcriptional regulator MSMEG_1317 139 COG1802 GntR, Transcriptional regulators Transcription 118468147 Common - glutamine synthetase MSMEG_3828 224 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 118471657 Common mfd transcription-repair coupling factor MSMEG_5423 226 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 118473071 Common - putative oxidoreductase MSMEG_6848 64 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118468139 Common - alpha subunit of malonate decarboxylase MSMEG_6635 27 None None None 118473638 Common - succinate dehydrogenase hydrophobic membrane anchor protein SdhD MSMEG_1671 13 COG2142 SdhD, Succinate dehydrogenase, hydrophobic anchor subunit Energy production and conversion 118469437 Common xylA xylose isomerase MSMEG_6021 76 COG2115 XylA, Xylose isomerase Carbohydrate transport and metabolism 118469954 Common - hydrolase, CocE/NonD family protein MSMEG_5283 59 COG2936 COG2936, Predicted acyl esterases General function prediction only 118473786 Common - HIT family protein hydrolase MSMEG_2932 66 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 118469789 Common - two-component system sensor kinase MSMEG_0854 153 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 118468615 Common - DNA-binding protein MSMEG_3449 26 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 118471203 Common - glutamine amidotransferase, class I MSMEG_1119 121 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 118470035 Common - AMP-binding enzyme MSMEG_2215 221 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118467472 Common - TetR-family protein regulatory protein MSMEG_0363 107 COG1309 AcrR, Transcriptional regulator Transcription 118472890 Common - hypothetical protein MSMEG_2381 23 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 118471847 Common - FAD binding domain protein MSMEG_6283 43 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 118469681 Common - transcriptional regulator, AraC family protein MSMEG_0376 112 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 118473346 Common - twin-arginine translocation pathway signal MSMEG_1102 104 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 118470011 Common - putative acyl-CoA dehydrogenase MSMEG_4806 118 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473862 Common - 3-hydroxybutyryl-CoA dehydrogenase MSMEG_6791 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 118470805 Common - NAD-glutamate dehydrogenase MSMEG_4699 77 COG2902 COG2902, NAD-specific glutamate dehydrogenase Amino acid transport and metabolism 118470240 Pathogen - hypothetical protein MSMEG_1324 1 None None None 118468001 Common - trap dicarboxylate transporter, dctm subunit MSMEG_6845 134 COG1593 DctQ, TRAP-type C4-dicarboxylate transport system, large permease component Carbohydrate transport and metabolism 118470462 Common - adenylate cyclase, family protein 3 MSMEG_6154 86 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 118472985 Common - sugar ABC transporter permease protein MSMEG_5572 168 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 118467819 Common - Cof-like hydrolase MSMEG_6407 131 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 118472313 Common - bifunctional uroporphyrinogen-III synthetase/response regulator domain protein MSMEG_0432 43 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 118472396 Common - glyoxylate reductase MSMEG_6299 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 118473688 Pathogen - hypothetical protein MSMEG_1685 1 None None None 118472667 Common - hypothetical protein MSMEG_3499 2 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 118471236 Common - transcription regulator MSMEG_1139 87 COG1396 HipB, Predicted transcriptional regulators Transcription 118467981 Common - LpqE protein MSMEG_6078 6 None None None 118472484 Common - AMP-dependent synthetase and ligase MSMEG_5942 174 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118469845 Pathogen - hypothetical protein MSMEG_5805 1 None None None 118471922 Common gabT 4-aminobutyrate transaminase MSMEG_6685 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 118470313 Common - mini-circle putative transposase for MSMEG_2646 31 None None None 118472317 Common - integral membrane protein MSMEG_2639 49 None None None 118472100 Common - glutamate transport ATP-binding protein GluA MSMEG_2728 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 118473545 Pathogen - hypothetical protein MSMEG_6347 1 None None None 118471507 Common - hypothetical protein MSMEG_0282 5 None None None 118468700 Common - virulence factor Mce family protein MSMEG_0350 14 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118472239 Common - transposase MSMEG_4133 102 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 118470817 Pathogen - hypothetical protein MSMEG_5480 1 None None None 118467657 Common - 2-deoxy-D-gluconate 3-dehydrogenase MSMEG_4117 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118473217 Common - hypothetical protein MSMEG_5949 3 None None None 118467538 Common - oxidoreductase, 2-nitropropane dioxygenase family protein MSMEG_6004 133 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 118470879 Common - dienelactone hydrolase family protein MSMEG_5236 8 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 118469786 Common sucC succinyl-CoA synthetase subunit beta MSMEG_5525 207 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 118473033 Common - integral membrane protein MSMEG_6665 5 None None None 118467560 Common - TetR-family protein transcriptional regulator MSMEG_0042 65 None None None 118469822 Common - metal-dependent hydrolase of the beta-lactamase superfamily protein III MSMEG_4902 49 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 118471718 Common - bifunctional urease subunit gamma/beta MSMEG_1093 96 COG0832 UreB, Urea amidohydrolase (urease) beta subunit Amino acid transport and metabolism 118473102 Common tkt transketolase MSMEG_3103 221 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 118468918 Common - major facilitator superfamily protein MSMEG_2486 171 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118471824 Common - hypothetical protein MSMEG_3641 10 None None None 118467812 Common nthA nitrile hydratase, alpha subunit MSMEG_0378 21 None None None 118471993 Common - zinc-binding oxidoreductase MSMEG_5762 179 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118469589 Common - hypothetical protein MSMEG_2901 5 None None None 118473149 Common - butyryl-CoA dehydrogenase MSMEG_4076 152 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118467426 Pathogen - hypothetical protein MSMEG_6181 1 None None None 118472489 Common - hypothetical protein MSMEG_0679 1 COG5373 COG5373, Predicted membrane protein Function unknown 118473515 Common - amylo-alpha-1,6-glucosidase MSMEG_5640 45 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 118474026 Common - methylmalonyl-CoA mutase, N-terminus of large subunit MSMEG_4881 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 118467988 Common - acyl-CoA synthetase MSMEG_5649 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118470236 Common - short chain dehydrogenase MSMEG_0771 236 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118472850 Common - sensor-type histidine kinase PrrB MSMEG_5663 208 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 118473255 Common atpG F0F1 ATP synthase subunit gamma MSMEG_4937 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 118469832 Common - DNA polymerase III subunit delta' MSMEG_6153 216 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 118470829 Common - cupin domain protein MSMEG_1585 10 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 118468189 Common - 6-aminohexanoate-cyclic-dimer hydrolase MSMEG_3505 211 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 118468132 Common - two component system histidine kinase MSMEG_4211 201 COG3290 CitA, Signal transduction histidine kinase regulating citrate/malate metabolism Signal transduction mechanisms 118467727 Common - hypothetical protein MSMEG_1406 1 None None None 118472208 Common - IS1096, tnpA protein MSMEG_2283 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118473666 Common - hypothetical protein MSMEG_2572 1 None None None 118467911 Common - D-amino-acid dehydrogenase MSMEG_6291 127 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 118468448 Common - integral membrane protein MSMEG_6614 102 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 118468012 Common - secreted protein MSMEG_5015 14 None None None 118470134 Common - 3-dehydroshikimate dehydratase MSMEG_2640 30 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 118471496 Common - transferase MSMEG_5979 97 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 118470634 Common - hexapeptide transferase family protein MSMEG_2335 132 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 118470683 Common - transmembrane transport protein MSMEG_0264 14 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118468382 Common - hypothetical protein MSMEG_6751 1 None None None 118473928 Common - hypothetical protein MSMEG_1149 5 COG2976 COG2976, Uncharacterized protein conserved in bacteria Function unknown 118473635 Common - mce-family protein mce1f MSMEG_0139 19 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118473855 Common ampC beta-lactamase MSMEG_3978 108 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 118470996 Common - indolepyruvate ferredoxin oxidoreductase MSMEG_5100 94 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 118469937 Common - long-chain specific acyl-CoA dehydrogenase MSMEG_5197 157 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472394 Common folP dihydropteroate synthase MSMEG_6103 218 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 118470967 Common - transcriptional regulator, LysR family protein MSMEG_5657 71 COG0583 LysR, Transcriptional regulator Transcription 118473573 Pathogen - hypothetical protein MSMEG_5539 1 None None None 118470577 Common aceE pyruvate dehydrogenase subunit E1 MSMEG_4323 156 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 118468731 Common lppH putative conserved lipoprotein lpph MSMEG_4597 1 None None None 118468666 Common - putative HTH-type transcriptional regulator YnfL MSMEG_1909 184 COG0583 LysR, Transcriptional regulator Transcription 118467826 Common ectB diaminobutyrate--2-oxoglutarate aminotransferase MSMEG_3900 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 118468602 Common - universal stress protein family protein, putative MSMEG_3308 63 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 118469190 Common - putative ECF sigma factor RpoE1 MSMEG_3485 172 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118467381 Common - leucyl aminopeptidase MSMEG_4281 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 118469471 Common - phosphoglycerate mutase family protein MSMEG_4579 174 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 118472115 Common - TPR-repeat-containing protein MSMEG_3754 18 None None None 118470736 Common - TetR family protein transcriptional regulatory protein MSMEG_3354 17 COG1309 AcrR, Transcriptional regulator Transcription 118470835 Common - SUF system FeS assembly protein, NifU family protein MSMEG_3126 139 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 118468207 Common - serine 3-dehydrogenase MSMEG_0930 225 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118468406 Common - transcriptional regulator, ArsR family protein MSMEG_4486 62 COG0640 ArsR, Predicted transcriptional regulators Transcription 118473026 Common - peroxidase MSMEG_3700 24 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 118471265 Common moaE molybdopterin converting factor, subunit 2 MSMEG_5701 53 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 118473908 Common recR recombination protein RecR MSMEG_6279 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 118471191 Common - siderophore utilization protein MSMEG_2511 62 COG2375 ViuB, Siderophore-interacting protein Inorganic ion transport and metabolism 118470975 Common - HNH endonuclease MSMEG_5106 6 None None None 118468733 Pathogen - hypothetical protein MSMEG_3329 1 None None None 118469120 Common - regulatory protein, MarR MSMEG_0538 95 COG1846 MarR, Transcriptional regulators Transcription 118473564 Common - IS1137, transposase orfB MSMEG_1721 140 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 118469325 Common hisH imidazole glycerol phosphate synthase subunit HisH MSMEG_3208 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 118470021 Common phhB pterin-4-alpha-carbinolamine dehydratase MSMEG_5150 104 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 118472812 Common - methylmalonyl-CoA mutase MSMEG_3159 111 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 118472017 Common - metallo-beta-lactamase superfamily protein MSMEG_2685 165 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 118472263 Common rplB 50S ribosomal protein L2 MSMEG_1439 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 118469506 Common - two-component system response regulator MSMEG_5306 78 COG4565 CitB, Response regulator of citrate/malate metabolism Transcription / Signal transduction mechanisms 118469019 Common - bacterial membrane flanked domain family protein MSMEG_0864 16 COG3402 COG3402, Uncharacterized conserved protein Function unknown 118470418 Pathogen - trans-sialidase, putative MSMEG_5012 1 None None None 118470756 Pathogen - hypothetical protein MSMEG_1653 1 None None None 118468651 Common - RNA polymerase sigma factor, sigma-70 family protein MSMEG_3275 2 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118471727 Common - ABC transporter ATP-binding protein MSMEG_5531 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 118472602 Common - glyoxalase family protein MSMEG_6630 7 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 118469278 Common - glycosyl trasferase MSMEG_4947 153 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 118473092 Common - acyltransferase family protein MSMEG_6409 117 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 118470082 Common - alcohol dehydrogenase MSMEG_1977 212 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 118469031 Common - RecB family protein exonuclease MSMEG_3907 21 COG2887 COG2887, RecB family exonuclease DNA replication, recombination, and repair 118472338 Pathogen - hypothetical protein MSMEG_6170 1 None None None 118471178 Common - galactonate dehydratase MSMEG_6177 124 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 118470385 Common ehuD ectoine/hydroxyectoine ABC transporter, permease protein EhuD MSMEG_3549 174 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 118470397 Common - hypothetical protein MSMEG_2591 1 None None None 118468315 Common - trp region conserved hypothetical membrane protein MSMEG_3218 3 None None None 118469897 Common - ISMsm2, transposase MSMEG_4522 52 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 118473228 Pathogen - hypothetical protein MSMEG_2448 1 None None None 118473335 Common - hypothetical protein MSMEG_5959 8 COG5653 COG5653, Protein involved in cellulose biosynthesis (CelD) Cell envelope biogenesis, outer membrane 118473824 Common - gluconolactonase MSMEG_1274 71 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 118470095 Pathogen - hypothetical protein MSMEG_4266 1 None None None 118468609 Common - hypothetical protein MSMEG_6678 3 None None None 118470085 Common - N5,N10- methylenetetrahydromethanopterin reductase-related protein MSMEG_6703 12 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118469632 Common - FAD dependent oxidoreductase MSMEG_0664 86 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118468524 Common - Xaa-Pro aminopeptidase MSMEG_2494 153 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 118472776 Common pntA NAD(P) transhydrogenase subunit alpha MSMEG_0110 161 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 118470762 Pathogen - hypothetical protein MSMEG_2008 1 None None None 118470246 Common - hypothetical protein MSMEG_2074 13 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 118470728 Common rplO 50S ribosomal protein L15 MSMEG_1474 206 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 118472650 Pathogen - hypothetical protein MSMEG_1054 1 None None None 118471881 Common - hypothetical protein MSMEG_2871 4 None None None 118472213 Common - aldehyde dehydrogenase MSMEG_0327 221 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118472124 Common - oxidoreductase, FAD-binding MSMEG_0295 133 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 118472431 Common - Mg/Co/Ni transporter MgtE MSMEG_5065 163 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 118469474 Common dnaG DNA primase MSMEG_4482 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 118471181 Common - phosphatidylinositol synthase MSMEG_2933 74 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 118470219 Common - peroxisomal hydratase-dehydrogenase-epimerase MSMEG_0096 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118469160 Common - amidohydrolase MSMEG_1702 147 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 118471891 Common - hypothetical protein MSMEG_2159 62 COG3220 COG3220, Uncharacterized protein conserved in bacteria Function unknown 118471182 Common - hypothetical protein MSMEG_3592 2 None None None 118470413 Common - hypothetical protein MSMEG_1210 57 COG1432 COG1432, Uncharacterized conserved protein Function unknown 118470325 Common - ABC transporter, permease protein OpuCB MSMEG_2927 148 COG1174 OpuBB, ABC-type proline/glycine betaine transport systems, permease component Amino acid transport and metabolism 118471650 Common - molybdenum import ATP-binding protein ModC MSMEG_2014 249 COG1118 CysA, ABC-type sulfate/molybdate transport systems, ATPase component Inorganic ion transport and metabolism 118469266 Common - morphological differentiation-associated protein MSMEG_6173 85 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 118470523 Common - transcriptional regulator, TetR family protein MSMEG_0606 4 COG1309 AcrR, Transcriptional regulator Transcription 118471880 Common senX3 sensor histidine kinase SenX3 MSMEG_0936 221 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 118473369 Common - transposase MSMEG_1726 102 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 118472003 Common gltX glutamyl-tRNA synthetase MSMEG_2383 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 118469001 Common - TetR-family protein transcriptional regulator MSMEG_3659 17 COG1309 AcrR, Transcriptional regulator Transcription 118468582 Common - amidohydrolase family protein MSMEG_0300 6 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118470374 Common - hypothetical protein MSMEG_5917 8 None None None 118473321 Common - FabG protein MSMEG_3581 233 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118470583 Common - sulfate permease MSMEG_1235 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 118469167 Common - hypothetical protein MSMEG_2877 2 None None None 118468738 Common argS arginyl-tRNA synthetase MSMEG_4959 246 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 118468043 Common - alpha/beta hydrolase fold family protein MSMEG_0289 76 COG0657 Aes, Esterase/lipase Lipid metabolism 118471547 Common - magnesium chelatase MSMEG_5512 64 COG1239 ChlI, Mg-chelatase subunit ChlI Coenzyme metabolism 118469333 Common - MATE efflux family protein MSMEG_2631 67 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 118470402 Common - hypothetical protein MSMEG_4361 8 None None None 118473921 Common - rhodanese-like domain protein MSMEG_6425 158 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 118470734 Common menA 1,4-dihydroxy-2-naphthoate octaprenyltransferase MSMEG_0988 83 COG1575 MenA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase Coenzyme metabolism 118470660 Common - permease of the major facilitator superfamily protein MSMEG_2991 184 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118471964 Common - ISMsm5, transposase MSMEG_0547 52 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 118471936 Common - mandelate racemase/muconate lactonizing enzyme MSMEG_0126 132 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 118472844 Common - endoribonuclease L-PSP family protein MSMEG_6875 30 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 118470769 Common - integral membrane protein MSMEG_6222 29 COG1714 COG1714, Predicted membrane protein/domain Function unknown 118470571 Common - ABC transporter, membrane spanning protein MSMEG_6123 218 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118472440 Common - ABC transporter ATP-binding protein MSMEG_1372 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 118467634 Common - hypothetical protein MSMEG_5062 18 None None None 118473873 Common - ABC-type transport system ATP-binding protein II MSMEG_1218 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 118470253 Common - hypothetical protein MSMEG_6186 51 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 118473175 Common - YtnM protein MSMEG_3735 25 COG0730 COG0730, Predicted permeases General function prediction only 118470646 Common - DNA-binding response regulator, LuxR family protein MSMEG_3240 183 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118471987 Common - glycosyl transferase, group 1 family protein MSMEG_4253 221 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 118472010 Common - putative acyl-CoA dehydrogenase MSMEG_5994 23 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473453 Common - hypothetical protein MSMEG_6590 15 None None None 118467344 Common - nitrite reductase [NAD(P)H] small subunit MSMEG_0428 44 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 118469639 Common - enoyl-CoA hydratase/isomerase MSMEG_0335 176 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118469039 Common - glutamine amidotransferase, class II MSMEG_6261 232 COG0067 GltB, Glutamate synthase domain 1 Amino acid transport and metabolism 118468250 Common - RNA polymerase sigma factor SigE MSMEG_5072 177 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118473287 Common - transferase MSMEG_1892 23 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 118470276 Common - ABC transport protein, ATP-binding subunit MSMEG_6052 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 118468235 Common hypE hydrogenase expression/formation protein HypE MSMEG_2705 180 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 118471944 Common - ferredoxin sulfite reductase MSMEG_4527 162 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 118469094 Common - beta-glucoside-specific EII permease MSMEG_2117 60 COG2190 NagE, Phosphotransferase system IIA components Carbohydrate transport and metabolism 118470294 Common - trehalose synthase-fused probable maltokinase MSMEG_6514 58 COG3281 Ble, Uncharacterized protein, probably involved in trehalose biosynthesis Carbohydrate transport and metabolism 118473955 Common - hypothetical protein MSMEG_0118 23 COG5516 COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding General function prediction only 118471688 Common - cytosine permease, putative MSMEG_3402 87 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 118473305 Common - pyrimidine regulatory protein PyrR MSMEG_3042 109 COG2065 PyrR, Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase Nucleotide transport and metabolism 118468312 Common - hypothetical protein MSMEG_2753 6 None None None 118472352 Common - UDP-glucose 6-dehydrogenase MSMEG_0680 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 118473946 Common - succinate semialdehyde dehydrogenase MSMEG_3304 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118473935 Common - acetyl-CoA acetyltransferase MSMEG_2207 187 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118469565 Common - GntR-family protein transcriptional regulator MSMEG_0286 119 COG2188 PhnF, Transcriptional regulators Transcription 118470600 Common - arylamine N-acetyltransferase MSMEG_0306 45 COG2162 NhoA, Arylamine N-acetyltransferase Secondary metabolites biosynthesis, transport, and catabolism 118472998 Pathogen - hypothetical protein MSMEG_6055 1 None None None 118473987 Common rpsM 30S ribosomal protein S13 MSMEG_1521 246 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 118467722 Common hemE uroporphyrinogen decarboxylase MSMEG_2780 177 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 118468657 Common - drug transporter MSMEG_5046 185 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118473551 Common - hypothetical protein MSMEG_4569 83 COG2307 COG2307, Uncharacterized protein conserved in bacteria Function unknown 118471722 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase MSMEG_0372 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118473353 Common - nicotine dehydrogenase chain A MSMEG_2463 85 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 118470513 Common - hypothetical protein MSMEG_1684 5 None None None 118470342 Common - integral membrane protein MSMEG_6783 2 None None None 118469810 Common - methylase, putative MSMEG_1771 86 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 118469097 Common - acetyltransferase, GNAT family protein MSMEG_5469 106 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 118470620 Common - putative tautomerase MSMEG_1607 3 COG1942 COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog General function prediction only 118471279 Common - IS1096, tnpR protein MSMEG_4946 44 None None None 118469027 Common - acyl-CoA dehydrogenase protein MSMEG_1905 125 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118468862 Pathogen - hypothetical protein MSMEG_2129 1 None None None 118468065 Common - putative permease of the major facilitator superfamily protein MSMEG_0705 199 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118467680 Common - putative secreted protein MSMEG_3493 1 None None None 118473996 Common - hypothetical protein MSMEG_1766 12 None None None 118472257 Common - undecaprenyl-phosphate galactosephosphotransferase MSMEG_5984 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 118467437 Common - subtilase family protein MSMEG_1533 74 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 118470576 Common - prolipoprotein diacylglyceryl transferase MSMEG_3222 155 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 118470651 Common - glycosyl transferase, group 1, putative MSMEG_5951 179 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 118467629 Common - hypothetical protein MSMEG_3214 2 None None None 118470988 Common - hypothetical protein MSMEG_0703 15 None None None 118471433 Common - cyclopropane-fatty-acyl-phospholipid synthase 1 MSMEG_0902 127 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 118474035 Common - aminoglycoside phosphotransferase MSMEG_4827 59 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 118473999 Common - gamma-glutamyltranspeptidase MSMEG_1463 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 118468038 Common - transcriptional regulator MSMEG_3765 49 COG1309 AcrR, Transcriptional regulator Transcription 118470716 Common - 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2, 4-dienoate decarboxylase MSMEG_6487 35 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118469838 Common - phosphoglycerate mutase family protein MSMEG_1926 172 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 118473659 Common - hypothetical protein MSMEG_4489 4 None None None 118471873 Common - alpha/beta hydrolase fold-1 MSMEG_6151 126 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118470580 Common alc allantoicase MSMEG_5727 15 COG4266 Alc, Allantoicase Nucleotide transport and metabolism 118471980 Common - MaoC family protein MSMEG_1341 64 COG2030 MaoC, Acyl dehydratase Lipid metabolism 118469050 Common - cytosine/purine/uracil/thiamine/allantoin permease family protein MSMEG_1683 42 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 118467415 Common - 2-keto-3-deoxy-galactonokinase MSMEG_6175 41 COG3734 DgoK, 2-keto-3-deoxy-galactonokinase Carbohydrate transport and metabolism 118473206 Common gcvT glycine cleavage system aminomethyltransferase T MSMEG_4278 178 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 118469042 Common - nuclear transport factor 2 (NTF2) domain superfamily protein MSMEG_5867 6 None None None 118468242 Common - virulence factor Mce family protein MSMEG_1146 9 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118470487 Common - dehydrogenase MSMEG_2344 15 COG3349 COG3349, Uncharacterized conserved protein Function unknown 118467923 Common - thiopurine S-methyltransferase (tpmt) superfamily protein MSMEG_6235 12 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 118469179 Common - ftsk/spoiiie family protein MSMEG_0062 34 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 118471043 Common - nucleoside-diphosphate-sugar epimerase MSMEG_6142 232 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118473808 Common glgC glucose-1-phosphate adenylyltransferase MSMEG_5078 173 COG0448 GlgC, ADP-glucose pyrophosphorylase Carbohydrate transport and metabolism 118470625 Common - IS1096, tnpA protein MSMEG_1404 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118469020 Pathogen - hypothetical protein MSMEG_3383 1 None None None 118473063 Common - cytochrome P450 MSMEG_4887 84 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118473990 Common - pyridoxamine 5'-phosphate oxidase family protein MSMEG_6526 8 None None None 118469401 Common - geranylgeranyl reductase MSMEG_1028 98 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 118472547 Common - oxidoreductase, molybdopterin-binding subunit MSMEG_0685 81 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 118470843 Common - hypothetical protein MSMEG_1270 1 None None None 118473326 Common groEL chaperonin GroEL MSMEG_1978 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 118467905 Common dapB dihydrodipicolinate reductase, N-terminus domain protein MSMEG_5286 19 COG3804 COG3804, Uncharacterized conserved protein related to dihydrodipicolinate reductase Function unknown 118469161 Common - hypothetical protein MSMEG_5259 105 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 118469559 Common - DNA-binding protein MSMEG_0523 41 COG1396 HipB, Predicted transcriptional regulators Transcription 118473741 Common - ABC transporter periplasmic-binding protein YtfQ MSMEG_1712 117 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118470698 Pathogen - hypothetical protein MSMEG_0727 1 None None None 118472501 Common murQ N-acetylmuramic acid-6-phosphate etherase MSMEG_0193 84 COG2103 COG2103, Predicted sugar phosphate isomerase General function prediction only 118473518 Common - xylulose kinase MSMEG_3263 177 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 118468769 Pathogen - hypothetical protein MSMEG_3963 1 None None None 118467364 Common - conserved hypothetical alanine rich protein MSMEG_2622 6 None None None 118469807 Common - virulence factor Mce family protein MSMEG_0347 80 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118472553 Common cysS cysteinyl-tRNA synthetase MSMEG_6074 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 118472707 Common - phosphotransferase enzyme family protein MSMEG_2042 54 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 118473024 Common - uracil DNA glycosylase superfamily protein MSMEG_0265 144 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 118470142 Common - hypothetical protein MSMEG_2293 38 COG4637 COG4637, Predicted ATPase General function prediction only 118473110 Common - MarR-family protein regulatory protein MSMEG_3415 88 COG1846 MarR, Transcriptional regulators Transcription 118469899 Common - TnpC protein MSMEG_1591 9 None None None 118474056 Common - FAD dependent oxidoreductase MSMEG_1649 75 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118473291 Common - hypothetical protein MSMEG_6061 14 COG3689 COG3689, Predicted membrane protein Function unknown 118470433 Common - probable conserved integral membrane protein MSMEG_3474 9 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 118467838 Common - IS1137, transposase orfB MSMEG_0725 140 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 118473488 Common - probable conserved transmembrane protein MSMEG_6400 5 None None None 118468415 Common - hypothetical protein MSMEG_0785 8 None None None 118470274 Pathogen - hypothetical protein MSMEG_5406 1 None None None 118473701 Pathogen - hypothetical protein MSMEG_4991 1 None None None 118470153 Common - UsfY protein MSMEG_4406 2 None None None 118473300 Common - carbon monoxide dehydrogenase medium chain MSMEG_0744 99 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 118474012 Common - OB-fold nucleic acid binding domain protein MSMEG_2768 12 None None None 118468901 Common - hypothetical protein MSMEG_5323 65 COG3176 COG3176, Putative hemolysin General function prediction only 118473645 Common - hydrolase, alpha/beta fold family protein MSMEG_1108 137 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118469323 Common - major facilitator family protein transporter MSMEG_4122 143 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118473119 Common - lipoprotein, nlpa family protein MSMEG_3058 100 COG1464 NlpA, ABC-type metal ion transport system, periplasmic component/surface antigen Inorganic ion transport and metabolism 118469546 Common - peptidase M20D, amidohydrolase MSMEG_3989 173 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 118469653 Common - hypothetical protein MSMEG_2246 5 None None None 118470103 Common - ATPase involved in DNA repair MSMEG_2731 28 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 118468817 Common - hypothetical protein MSMEG_0722 1 None None None 118473002 Common trx thioredoxin MSMEG_6934 233 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 118468543 Common - ribosyldihydronicotinamide dehydrogenase (quinone) MSMEG_0284 59 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 118471135 Common - hypothetical protein MSMEG_0857 2 None None None 118470337 Common - major facilitator superfamily protein MSMEG_2549 187 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118471595 Common - hypothetical protein MSMEG_5328 19 None None None 118473782 Common - hypothetical protein MSMEG_4030 25 COG3059 COG3059, Predicted membrane protein Function unknown 118473989 Common - hypothetical protein MSMEG_0200 1 COG1390 NtpE, Archaeal/vacuolar-type H+-ATPase subunit E Energy production and conversion 118470568 Common - oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_1628 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118467946 Common thyA thymidylate synthase MSMEG_2670 141 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 118471666 Common - IS1096, tnpR protein MSMEG_4791 44 None None None 118469423 Common - hypothetical protein MSMEG_4421 5 None None None 118471582 Common rpsO 30S ribosomal protein S15 MSMEG_2654 214 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 118471696 Common - hypothetical protein MSMEG_0412 1 None None None 118467965 Common - acyl-CoA dehydrogenase family protein MSMEG_4547 97 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118469172 Common - hypothetical protein MSMEG_4637 19 None None None 118473179 Common - homoserine dehydrogenase MSMEG_4957 212 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 118469455 Common - hypothetical protein MSMEG_6116 17 COG3195 COG3195, Uncharacterized protein conserved in bacteria Function unknown 118472156 Pathogen - hypothetical protein MSMEG_6827 1 None None None 118473116 Common - carboxymuconolactone decarboxylase MSMEG_6797 43 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 118471818 Common - sensory histidine kinase MSMEG_0106 91 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 118473230 Common - N-acetylmuramoyl-L-alanine amidase MSMEG_6406 17 COG5479 COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis Cell envelope biogenesis, outer membrane 118472491 Common - DoxX subfamily protein, putative MSMEG_3255 18 COG2259 COG2259, Predicted membrane protein Function unknown 118469737 Common - hypothetical protein MSMEG_0768 43 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 118472220 Common proC pyrroline-5-carboxylate reductase MSMEG_0943 214 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 118468795 Common pyrH uridylate kinase MSMEG_2540 240 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 118467439 Common - hypothetical protein MSMEG_4570 89 COG2308 COG2308, Uncharacterized conserved protein Function unknown 118469621 Common - ISMsm5, transposase MSMEG_4072 52 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 118471765 Common - virulence factor Mce family protein MSMEG_5818 6 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118468760 Common - hypothetical protein MSMEG_2699 8 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 118469013 Common - carbon-monoxide dehydrogenase MSMEG_2949 109 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 118473859 Common - isochorismatase hydrolase MSMEG_4396 15 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 118468637 Common - putative transposition helper protein MSMEG_1858 95 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 118472196 Common - putative carboxylesterase protein MSMEG_2534 60 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118467677 Common - AP endonuclease, family protein 2 MSMEG_6716 26 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 118471052 Common - glutamine transport ATP-binding protein GlnQ MSMEG_1614 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 118471083 Common - hypothetical protein MSMEG_2755 10 COG1295 Rbn, Predicted membrane protein Function unknown 118468625 Common fmt methionyl-tRNA formyltransferase MSMEG_3064 215 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 118468786 Common - cobalamin synthesis protein/P47K MSMEG_6048 128 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 118467412 Common - O-methyltransferase, putative MSMEG_6661 29 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118468143 Common - hypothetical protein MSMEG_4863 130 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118472342 Common - hypothetical protein MSMEG_0067 40 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 118468720 Common - acetoacetyl-CoA reductase MSMEG_3912 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470627 Common atpA F0F1 ATP synthase subunit alpha MSMEG_4938 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 118470949 Common - amidohydrolase 2 MSMEG_4043 43 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118467714 Common - transcriptional regulator, GntR family protein MSMEG_6789 134 COG1802 GntR, Transcriptional regulators Transcription 118469573 Common - cupin domain protein MSMEG_4441 2 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 118468579 Common - ppe family protein MSMEG_0064 1 COG5651 COG5651, PPE-repeat proteins Cell motility and secretion 118470479 Common - transport protein MSMEG_2287 42 COG0730 COG0730, Predicted permeases General function prediction only 118467440 Common - sensory box/response regulator MSMEG_2196 177 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 118468961 Common - taurine import ATP-binding protein TauB MSMEG_0116 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 118473224 Common - citrate synthase 2 MSMEG_5676 188 COG0372 GltA, Citrate synthase Energy production and conversion 118472654 Pathogen - hypothetical protein MSMEG_3922 1 None None None 118473960 Common - RNA polymerase sigma-70 factor MSMEG_1747 138 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118471112 Common - hypothetical protein MSMEG_1545 6 COG4114 FhuF, Uncharacterized Fe-S protein General function prediction only 118472089 Common - 3-demethylubiquinone-9 3-methyltransferase MSMEG_0218 64 COG3865 COG3865, Uncharacterized protein conserved in bacteria Function unknown 118468437 Common - endonuclease IV MSMEG_1383 107 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 118472333 Common - two-component system response regulator MSMEG_3447 197 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 118470447 Common pyc pyruvate carboxylase MSMEG_6648 233 COG1038 PycA, Pyruvate carboxylase Energy production and conversion 118473014 Common - integral membrane protein MSMEG_6217 11 None None None 118471844 Common - serine-threonine protein kinase MSMEG_0028 158 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 118468035 Common - chloramphenicol resistance protein MSMEG_2028 141 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118471830 Common - hypothetical protein MSMEG_0119 1 None None None 118473341 Common - hypothetical protein MSMEG_0570 16 None None None 118472814 Common - glycosyl transferase, group 1 family protein MSMEG_5641 124 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 118472957 Common - probable conserved mce associated membrane protein MSMEG_0143 2 None None None 118471366 Common - Tat (twin-arginine translocation) pathway signal sequence MSMEG_4521 92 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 118471919 Common - hypothetical protein MSMEG_0466 8 None None None 118470292 Common - putative hydrolase MSMEG_4079 96 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118468492 Common - hypothetical protein MSMEG_3560 14 None None None 118471461 Common rpsS 30S ribosomal protein S19 MSMEG_1440 240 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 118471578 Common - hypothetical protein MSMEG_2980 144 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 118470453 Common - efflux ABC transporter, permease protein MSMEG_2522 1 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 118471731 Common - hypothetical protein MSMEG_6468 23 COG0122 AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 118468290 Common - translation initiation inhibitor MSMEG_1464 64 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 118469118 Common infB translation initiation factor IF-2 MSMEG_2628 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 118471393 Common - L-ornithine 5-monooxygenase MSMEG_0022 52 COG3486 IucD, Lysine/ornithine N-monooxygenase Secondary metabolites biosynthesis, transport, and catabolism 118473375 Common - hypothetical protein MSMEG_0317 8 None None None 118467639 Pathogen - hypothetical protein MSMEG_5692 1 None None None 118472031 Common - sugar binding-protein dependent transporter system permease MSMEG_0517 142 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 118471612 Common - prolyl oligopeptidase family protein MSMEG_0899 102 COG1505 COG1505, Serine proteases of the peptidase family S9A Amino acid transport and metabolism 118470109 Common nuoN NADH dehydrogenase subunit N MSMEG_2050 209 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 118473884 Common - O-acetylhomoserine/O-acetylserine sulfhydrylase MSMEG_0239 207 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 118469241 Common - hypothetical protein MSMEG_4720 1 None None None 118467789 Common - formyl-coenzyme A transferase MSMEG_0158 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118471011 Common - hypothetical protein MSMEG_6089 13 COG5446 COG5446, Predicted integral membrane protein Function unknown 118473693 Common - transcriptional regulator, TetR family protein MSMEG_0227 101 COG1309 AcrR, Transcriptional regulator Transcription 118468112 Common - regulatory protein GntR, HTH MSMEG_5174 126 COG1725 COG1725, Predicted transcriptional regulators Transcription 118472680 Pathogen - hypothetical protein MSMEG_2168 1 None None None 118468957 Pathogen - hypothetical protein MSMEG_3453 1 None None None 118467419 Common - glycolate oxidase MSMEG_0595 164 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 118469342 Common cydB cytochrome D ubiquinol oxidase, subunit II MSMEG_3232 156 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 118468598 Common - xylosidase/arabinosidase MSMEG_5144 168 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 118471469 Common - hypothetical protein MSMEG_5607 1 None None None 118472884 Common - ABC transporter, permease/ATP-binding protein MSMEG_0018 231 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 118469640 Common - membrane spanning protein MSMEG_5546 50 COG1950 COG1950, Predicted membrane protein Function unknown 118471630 Common - integral membrane protein MSMEG_6680 18 COG3059 COG3059, Predicted membrane protein Function unknown 118473857 Common - acyl-CoA dehydrogenase MSMEG_4844 139 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472699 Common - hypothetical protein MSMEG_4783 1 None None None 118469879 Common - hypothetical protein MSMEG_4967 15 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118467969 Common - nitrate transport ATP-binding protein NrtD MSMEG_2102 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 118473404 Common - transcriptional regulator, putative MSMEG_0540 61 COG2808 PaiB, Transcriptional regulator Transcription 118468888 Common - hypothetical protein MSMEG_2733 7 COG3885 COG3885, Uncharacterized conserved protein Function unknown 118469727 Common - virulence factor Mce family protein MSMEG_2859 6 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118468294 Common - ErfK/YbiS/YcfS/YnhG family protein MSMEG_0929 15 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 118467926 Common ureG urease accessory protein UreG MSMEG_1095 157 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 118472285 Pathogen - hypothetical protein MSMEG_3501 1 None None None 118472099 Common - hypothetical protein MSMEG_0888 1 None None None 118473016 Common - sulfatase-modifying factor 1 MSMEG_1452 109 COG1262 COG1262, Uncharacterized conserved protein Function unknown 118472862 Common - hypothetical protein MSMEG_2820 1 None None None 118468078 Common sdhA succinate dehydrogenase flavoprotein subunit MSMEG_1670 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 118470114 Common - hypothetical protein MSMEG_3809 10 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118467646 Common - extracellular solute-binding protein, family protein 1 MSMEG_5145 98 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118472666 Common - FAD binding domain in molybdopterin dehydrogenase protein MSMEG_1292 17 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 118471806 Common - hypothetical protein MSMEG_3191 5 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 118468124 Common - putative esterase superfamily protein MSMEG_5851 7 COG0627 COG0627, Predicted esterase General function prediction only 118467744 Common - integral membrane transporter MSMEG_1448 154 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 118473641 Common - MOSC domain protein MSMEG_3411 49 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 118473007 Common - hypothetical protein MSMEG_5578 1 None None None 118472060 Common - ABC transporter permease protein MSMEG_4763 213 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 118468083 Common - hypothetical protein MSMEG_5409 2 None None None 118469884 Common - FMN-dependent dehydrogenase MSMEG_1424 122 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 118471927 Common - hypothetical protein MSMEG_1806 9 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 118467809 Common dinB DNA polymerase IV MSMEG_2294 185 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 118472067 Pathogen - hypothetical protein MSMEG_5391 1 None None None 118469124 Common - sulfatase family protein MSMEG_1286 41 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 118470564 Common - branched-chain amino acid ABC transporter substrate-binding protein MSMEG_3247 133 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 118473473 Common - peptide synthetase ScpsB, putative MSMEG_4963 26 COG4908 COG4908, Uncharacterized protein containing a NRPS condensation (elongation) domain General function prediction only 118472888 Common recD exodeoxyribonuclease V, alpha subunit MSMEG_1325 128 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 118472477 Common - oxidoreductase MSMEG_3911 17 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118468418 Common - hypothetical protein MSMEG_5352 32 COG2388 COG2388, Predicted acetyltransferase General function prediction only 118470470 Common - TetR-family protein transcriptional regulator MSMEG_1967 5 COG1309 AcrR, Transcriptional regulator Transcription 118473523 Common - recombination factor protein RarA MSMEG_3021 245 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 118473049 Common - hypothetical protein MSMEG_5048 8 None None None 118472265 Common - chromosome replication initiation inhibitor protein MSMEG_0548 111 COG0583 LysR, Transcriptional regulator Transcription 118472600 Common - transcriptional regulator, TetR family protein MSMEG_2898 46 COG1309 AcrR, Transcriptional regulator Transcription 118469395 Common - hypothetical protein MSMEG_5972 3 None None None 118473237 Common rpmI 50S ribosomal protein L35 MSMEG_3792 147 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 118473789 Pathogen - hypothetical protein MSMEG_4481 1 None None None 118472443 Common - hypothetical protein MSMEG_2662 1 None None None 118469852 Common sucD succinyl-CoA synthetase subunit alpha MSMEG_5524 211 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 118468933 Pathogen - hypothetical protein MSMEG_1815 1 None None None 118469776 Common - glutamate transporter permease protein GluD MSMEG_2725 161 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 118471335 Common - polyphosphate glucokinase MSMEG_2760 80 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 118469668 Common - hypothetical protein MSMEG_0963 1 None None None 118473826 Common - secreted protein MSMEG_2112 9 None None None 118468516 Common - putative hydrolase MSMEG_2984 4 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118470695 Common - regulatory protein MSMEG_4370 24 COG3835 CdaR, Sugar diacid utilization regulator Transcription / Signal transduction mechanisms 118472866 Common - Rieske [2Fe-2S] domain protein MSMEG_0734 67 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 118472543 Common - LysR-family protein transcriptional regulator MSMEG_6849 189 COG0583 LysR, Transcriptional regulator Transcription 118471791 Common - efflux protein MSMEG_2619 202 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118473070 Common - uracil-DNA glycosylase superfamily protein MSMEG_5031 74 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 118474021 Common glnA glutamine synthetase, type I MSMEG_4294 227 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 118470174 Common - hypothetical protein MSMEG_4884 3 None None None 118468377 Common - integral membrane transport protein MSMEG_4889 139 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118471960 Common - riboflavin biosynthesis protein RibD C- domain protein MSMEG_5219 33 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 118467655 Common - 3-oxoacyl-(acyl carrier protein) synthase II MSMEG_4328 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118472996 Common - acyl-CoA synthetase MSMEG_5086 188 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118467459 Common - cytochrome P450 MSMEG_0968 83 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118468320 Common - hypothetical protein MSMEG_2638 21 None None None 118468008 Common - linear gramicidin synthetase subunit D MSMEG_0402 218 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 118469416 Common - cytochrome P450 109 MSMEG_5861 83 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118467431 Common - nitrilase 2 MSMEG_5373 57 COG0388 COG0388, Predicted amidohydrolase General function prediction only 118468378 Common - Trypsin MSMEG_6289 220 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 118469900 Pathogen - hypothetical protein MSMEG_5355 1 None None None 118467578 Common dut deoxyuridine 5'-triphosphate nucleotidohydrolase MSMEG_2765 183 COG0756 Dut, dUTPase Nucleotide transport and metabolism 118470885 Common - radical SAM domain protein MSMEG_1423 184 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 118471448 Common - solute-binding lipoprotein MSMEG_6050 148 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 118470064 Pathogen - gp36 protein MSMEG_2142 1 None None None 118472390 Common - sugar ABC-transporter integral membrane protein MSMEG_5147 145 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 118467936 Common lysA diaminopimelate decarboxylase MSMEG_4958 217 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 118467525 Common - hypothetical protein MSMEG_6426 1 None None None 118472590 Common - phosphoglycolate phosphatase, chromosomal MSMEG_4183 186 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 118471092 Common - alkanal monooxygenase MSMEG_4092 133 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118469983 Common - hypothetical protein MSMEG_5582 1 None None None 118470960 Pathogen - hypothetical protein MSMEG_1163 1 None None None 118471070 Common bioF 8-amino-7-oxononanoate synthase MSMEG_3189 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 118470753 Common - choline dehydrogenase MSMEG_3432 92 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 118469465 Common - NTP pyrophosphohydrolase MSMEG_1446 27 COG2816 NPY1, NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding DNA replication, recombination, and repair 118472893 Common - amidase MSMEG_4381 65 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 118471976 Common - beta-lactamase MSMEG_3914 71 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 118469306 Common - peptidase, A24 (type IV prepilin peptidase) family protein MSMEG_3029 1 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 118467402 Pathogen - hypothetical protein MSMEG_0450 1 None None None 118473426 Common - putative dehydrogenase MSMEG_0196 64 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118469113 Common - acyl-CoA synthase MSMEG_2672 136 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118469204 Common greA transcription elongation factor GreA MSMEG_5263 203 COG0782 GreA, Transcription elongation factor Transcription 118472386 Common - oxidoreductase, zinc-binding dehydrogenase family protein MSMEG_4002 196 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 118473839 Common - integral membrane protein MSMEG_4208 75 COG3333 COG3333, Uncharacterized protein conserved in bacteria Function unknown 118472532 Common - NAD/mycothiol-dependent formaldehyde dehydrogenase MSMEG_4340 207 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 118471330 Common - hypothetical protein MSMEG_3419 2 None None None 118471162 Common - putative membrane transport ATPase MSMEG_4250 93 COG0003 ArsA, Predicted ATPase involved in chromosome partitioning Cell division and chromosome partitioning 118472938 Pathogen - hypothetical protein MSMEG_2482 1 None None None 118470927 Common - ABC transporter binding protein MSMEG_4762 123 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 118469380 Common frcK putative fructose transport system kinase MSMEG_6800 39 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 118470196 Common - putative conserved transmembrane protein MSMEG_0959 4 None None None 118473720 Common - peptidase family protein M20/M25/M40 MSMEG_2100 125 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 118472712 Common - putative acyl-CoA dehydrogenase MSMEG_1387 147 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118471387 Common - hypothetical protein MSMEG_4885 13 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 118468281 Common - acetyltransferase, gnat family protein MSMEG_0830 10 COG0456 RimI, Acetyltransferases General function prediction only 118471781 Common - oxidoreductase MSMEG_4013 40 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118472326 Common - hypothetical protein MSMEG_3888 43 COG2378 COG2378, Predicted transcriptional regulator Transcription 118471277 Common cobF precorrin 6A synthase MSMEG_5548 34 COG2243 CobF, Precorrin-2 methylase Coenzyme metabolism 118469960 Pathogen - hypothetical protein MSMEG_1589 1 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 118473277 Common - transcriptional regulator, TetR family protein MSMEG_6527 1 COG1309 AcrR, Transcriptional regulator Transcription 118470983 Common - heat shock protein HtpX MSMEG_1134 192 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 118472845 Common - hydrolase MSMEG_0117 142 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118473162 Common - amino acid permease MSMEG_1412 192 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118468821 Common - glyoxalase/bleomycin resistance protein/dioxygenase MSMEG_5678 44 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 118471156 Common - hypothetical protein MSMEG_0917 49 COG2733 COG2733, Predicted membrane protein Function unknown 118472272 Common - hypothetical protein MSMEG_4784 1 None None None 118472412 Common - flavoprotein MSMEG_4334 174 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 118472621 Common - ISMsm6, transposase MSMEG_1222 24 COG5421 COG5421, Transposase DNA replication, recombination, and repair 118469389 Common - ABC-transporter integral membrane protein MSMEG_1141 128 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 118467498 Common - aldehyde dehydrogenase (NAD) family protein MSMEG_2238 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118467793 Pathogen - hypothetical protein MSMEG_1724 2 None None None 118468255 Common - hypothetical protein MSMEG_5705 15 None None None 118468095 Common - coenzyme B12-dependent glycerol dehydrogenase small subunit MSMEG_0496 13 COG4910 PduE, Propanediol dehydratase, small subunit Secondary metabolites biosynthesis, transport, and catabolism 118471937 Common - IS1096, tnpR protein MSMEG_1058 44 None None None 118472090 Common - bifunctional wax ester synthase/acyl-CoA diacylglycerol acyltransferase MSMEG_6322 27 None None None 118472565 Common - N-acetyltransferase Ats1 MSMEG_1924 80 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 118468997 Common - sodium:solute symporter MSMEG_3689 157 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 118469178 Common - hypothetical protein MSMEG_4284 109 COG1090 COG1090, Predicted nucleoside-diphosphate sugar epimerase General function prediction only 118470819 Common - Holliday junction resolvase-like protein MSMEG_3026 92 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 118471827 Common - oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_5802 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118472082 Common - L-carnitine dehydratase/bile acid-inducible protein F MSMEG_4798 114 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118467482 Common - probable conserved membrane protein MSMEG_0904 1 None None None 118472427 Common - thiopurine S-methyltransferase (tpmt) superfamily protein MSMEG_3041 74 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 118470378 Common - 3-oxoacyl-[acyl carrier protein] reductase MSMEG_4375 217 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118472185 Common - acyl-CoA dehydrogenase family protein member 8 MSMEG_1497 165 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118470771 Common - pe family protein MSMEG_6144 1 None None None 118471945 Common - sugar transport system MSMEG_0516 156 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 118473184 Common - hypothetical protein MSMEG_3819 1 None None None 118468504 Common - regulatory protein MSMEG_3290 20 COG3899 COG3899, Predicted ATPase General function prediction only 118468363 Common - transcriptional regulator, TetR family protein MSMEG_4847 12 COG1309 AcrR, Transcriptional regulator Transcription 118473180 Common - IS1096, tnpA protein MSMEG_4945 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118471969 Common - DoxX subfamily protein, putative MSMEG_5203 28 COG2259 COG2259, Predicted membrane protein Function unknown 118471126 Common - hypothetical protein MSMEG_0399 37 COG3251 COG3251, Uncharacterized protein conserved in bacteria Function unknown 118467780 Common - C5-O-methyltransferase MSMEG_6663 5 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118472749 Common - hypothetical protein MSMEG_0729 5 None None None 118469949 Common - putative oxidoreductase MSMEG_1968 192 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118473309 Common - monooxygenase, FAD-binding MSMEG_2485 124 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118472132 Common - acetyl-CoA synthetase MSMEG_6024 211 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 118469154 Common - oxidoreductase, 2OG-Fe(II) oxygenase family protein MSMEG_2569 52 COG3491 PcbC, Isopenicillin N synthase and related dioxygenases General function prediction only 118473764 Common - dipeptidase 2 MSMEG_3731 102 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 118471544 Common - sigma associated protein MSMEG_0404 27 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 118473771 Pathogen - hypothetical protein MSMEG_4051 1 None None None 118468884 Common - transcriptional regulator, TetR family protein MSMEG_1842 5 COG1309 AcrR, Transcriptional regulator Transcription 118467751 Pathogen - hypothetical protein MSMEG_4944 1 None None None 118470055 Common - penicillin-binding protein, transpeptidase MSMEG_6319 180 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 118470077 Pathogen - hypothetical protein MSMEG_0869 1 None None None 118468273 Common - iron-dependent repressor IdeR MSMEG_2750 85 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 118471408 Common - propane monooxygenase coupling protein MSMEG_1974 9 None None None 118470318 Common - dioxygenase MSMEG_5913 112 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 118469990 Common - ABC transporter, substrate binding protein [nitrate/sulfonate], putative MSMEG_2099 118 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 118468775 Common - putative regulatory protein, FmdB family protein MSMEG_4368 2 COG2331 COG2331, Uncharacterized protein conserved in bacteria Function unknown 118472613 Common - cupin 2, conserved barrel MSMEG_4420 20 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 118472931 Common - carveol dehydrogenase ((+)-trans-carveol dehydrogenase) MSMEG_2204 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471456 Common ppnK inorganic polyphosphate/ATP-NAD kinase MSMEG_3750 239 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 118472768 Common - peptidyl-prolyl cis-trans isomerase, fkbp-type domain protein MSMEG_3434 90 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 118471970 Common - MerR-family protein transcriptional regulator MSMEG_1969 107 COG0789 SoxR, Predicted transcriptional regulators Transcription 118472760 Common ppa inorganic pyrophosphatase MSMEG_6114 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 118471787 Common cobK cobalt-precorrin-6x reductase MSMEG_3875 74 COG2099 CobK, Precorrin-6x reductase Coenzyme metabolism 118472995 Common ileS isoleucyl-tRNA synthetase MSMEG_3169 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 118470746 Common - conserved protein, DUF59 MSMEG_3127 140 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 118471511 Common - decarboxylase MSMEG_2490 34 COG3473 COG3473, Maleate cis-trans isomerase Secondary metabolites biosynthesis, transport, and catabolism 118471455 Common - oxidoreductase MSMEG_5909 195 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118468838 Common - ABC transporter ATP-binding protein MSMEG_6802 248 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 118469797 Common - hypothetical protein MSMEG_1770 3 None None None 118471061 Common aroK shikimate kinase MSMEG_3031 201 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 118470120 Common - putative acetyltransferase MSMEG_2306 14 COG3393 COG3393, Predicted acetyltransferase General function prediction only 118471879 Common - hypothetical protein MSMEG_2315 8 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 118472897 Common - probable conserved transmembrane protein MSMEG_4237 16 None None None 118473547 Common - IS1096, tnpR protein MSMEG_6156 44 None None None 118470970 Common - coenzyme A transferase, subunit B MSMEG_6003 35 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 118470287 Common gcvP glycine dehydrogenase MSMEG_3642 172 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 118468548 Common - putative hydroxyacid aldolase MSMEG_3346 74 COG3836 HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase Carbohydrate transport and metabolism 118470786 Common - protease MSMEG_4296 40 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118468535 Common - transcriptional regulator, TetR family protein MSMEG_4333 22 COG1309 AcrR, Transcriptional regulator Transcription 118472633 Common - transcriptional regulatory protein, AsnC family protein MSMEG_2397 25 COG1522 Lrp, Transcriptional regulators Transcription 118472628 Common cbiM cobalamin biosynthesis protein CbiM MSMEG_2607 79 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 118470931 Common - metallo-beta-lactamase family protein MSMEG_1334 219 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 118470369 Common - virulence factor mce family protein MSMEG_2858 25 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118471378 Common - acyl-CoA synthetase MSMEG_1098 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118469977 Common - hypothetical protein MSMEG_2754 18 None None None 118472537 Pathogen - hypothetical protein MSMEG_1783 1 None None None 118467704 Common hypC hydrogenase assembly chaperone HypC/HupF MSMEG_2274 89 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 118471476 Common - ErfK/YbiS/YcfS/YnhG family protein MSMEG_1322 17 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 118473562 Common - hypothetical protein MSMEG_5844 10 COG2852 COG2852, Uncharacterized protein conserved in bacteria Function unknown 118473980 Pathogen - hypothetical protein MSMEG_0799 1 None None None 118471549 Pathogen - hypothetical protein MSMEG_1627 1 None None None 118468080 Common - hypothetical protein MSMEG_3060 18 COG3714 COG3714, Predicted membrane protein Function unknown 118473626 Common - hypothetical protein MSMEG_0353 3 None None None 118473513 Common - transcriptional regulator, LysR family protein MSMEG_5000 95 COG0583 LysR, Transcriptional regulator Transcription 118467409 Common - hypothetical protein MSMEG_1384 8 COG3450 COG3450, Predicted enzyme of the cupin superfamily General function prediction only 118472026 Pathogen - hypothetical protein MSMEG_5169 1 None None None 118472912 Common - hypothetical protein MSMEG_5154 3 None None None 118468531 Common - P450 heme-thiolate protein MSMEG_0681 66 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118469869 Common - glutamyl-tRNA(Gln) amidotransferase subunit A MSMEG_3970 220 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 118470167 Common - CaiB/BaiF family protein MSMEG_4877 115 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118471762 Common - hypothetical protein MSMEG_6164 1 None None None 118469665 Common - N5,N10-methylene- tetrahydromethanopterin reductase MSMEG_3554 37 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118469647 Common - 2-keto-4-pentenoate hydratase MSMEG_5940 66 COG3971 COG3971, 2-keto-4-pentenoate hydratase Secondary metabolites biosynthesis, transport, and catabolism 118467998 Common - acyl-CoA dehydrogenase MSMEG_3982 162 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118467477 Pathogen - hypothetical protein MSMEG_5200 1 None None None 118472171 Common - hypothetical oxidoreductase YeiQ MSMEG_2907 90 COG0246 MtlD, Mannitol-1-phosphate/altronate dehydrogenases Carbohydrate transport and metabolism 118471649 Common - hypothetical protein MSMEG_4336 17 None None None 118468742 Common - ABC-type sugar transport system ATPase component MSMEG_6019 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 118473497 Common - 2-nitropropane dioxygenase, NPD MSMEG_0332 82 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 118467501 Common - hypothetical protein MSMEG_5445 209 COG0313 COG0313, Predicted methyltransferases General function prediction only 118471081 Common - membrane associated protein MSMEG_3651 24 COG3879 COG3879, Uncharacterized protein conserved in bacteria Function unknown 118473672 Common - transporter ATPase MSMEG_2502 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 118470723 Common - cobalt-zinc-cadmium resistance protein MSMEG_0755 179 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 118471440 Common - biotin sulfoxide reductase MSMEG_2738 168 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 118468022 Common - amino acid permease, putative MSMEG_6735 96 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118470281 Common zwf glucose-6-phosphate 1-dehydrogenase MSMEG_0314 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 118469199 Common nirB nitrite reductase [NAD(P)H], large subunit MSMEG_0427 195 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 118472580 Pathogen - hypothetical protein MSMEG_5152 1 None None None 118472266 Common - phosphoenolpyruvate carboxykinase MSMEG_0255 59 COG1274 PckA, Phosphoenolpyruvate carboxykinase (GTP) Energy production and conversion 118468563 Common - Bacterial extracellular solute-binding protein MSMEG_0660 123 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 118469946 Common - glyoxalase family protein MSMEG_5680 66 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 118470151 Common - hypothetical protein MSMEG_1601 7 None None None 118470898 Common - antigen 34 kDa MSMEG_5518 1 None None None 118471341 Common - transcriptional regulator, TetR family protein MSMEG_3572 2 COG1309 AcrR, Transcriptional regulator Transcription 118467769 Common - methyltransferase, UbiE/COQ5 family protein MSMEG_2329 182 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118473832 Common - transcriptional regulator, LysR family protein MSMEG_4667 178 COG0583 LysR, Transcriptional regulator Transcription 118473380 Common - methyltransferase type 11 MSMEG_6483 152 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118471424 Common - transcriptional regulator MSMEG_3741 144 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 118469364 Common - DoxX subfamily protein, putative MSMEG_2370 11 COG2259 COG2259, Predicted membrane protein Function unknown 118470381 Common - hypothetical protein MSMEG_2484 7 None None None 118470184 Pathogen - hypothetical protein MSMEG_3588 1 None None None 118472575 Common - hypothetical protein MSMEG_3683 2 None None None 118473860 Common - ABC transporter, ATP-binding protein MSMEG_4357 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 118469434 Common - lactate 2-monooxygenase MSMEG_2512 110 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 118470938 Common - ABC transporter, ATP-binding protein MSMEG_2844 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 118467358 Common - immunogenic protein MPT63 MSMEG_5617 1 None None None 118472529 Common dtd D-tyrosyl-tRNA deacylase MSMEG_4291 139 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 118471155 Common - hypothetical protein MSMEG_4734 1 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 118472057 Common - hypothetical protein MSMEG_1189 1 None None None 118467549 Common - glutamine amidotransferase class-I MSMEG_6690 107 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 118469689 Common treZ malto-oligosyltrehalose trehalohydrolase MSMEG_3184 160 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 118468222 Common - hypothetical protein MSMEG_3629 3 None None None 118470920 Common - putative TetR family protein receptor protein MSMEG_0561 5 None None None 118473894 Common - hypothetical protein MSMEG_5207 4 None None None 118469972 Common - oxidoreductase, NAD/FAD-binding MSMEG_2893 135 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 118468422 Common - peptidyl-prolyl cis-trans isomerase B MSMEG_0024 184 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 118470186 Common upp uracil phosphoribosyltransferase MSMEG_1694 164 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 118471285 Common - putative regulatory protein MSMEG_4431 75 COG3899 COG3899, Predicted ATPase General function prediction only 118471746 Common - methylcitrate synthase MSMEG_6647 193 COG0372 GltA, Citrate synthase Energy production and conversion 118468556 Common - ABC transporter, membrane spanning protein MSMEG_6122 219 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118472469 Common - IS1549, transposase MSMEG_1865 24 COG5421 COG5421, Transposase DNA replication, recombination, and repair 118472173 Common - hypothetical protein MSMEG_3545 1 None None None 118469674 Common - NrtC protein MSMEG_4519 20 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472468 Common - hypothetical protein MSMEG_6902 5 None None None 118469105 Common - small membrane hydrophobic protein MSMEG_0039 6 None None None 118467612 Common - oxidoreductase, short chain dehydrogenase/reductase family protein MSMEG_2228 231 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118472377 Common - acyl-ACP thioesterase superfamily protein MSMEG_0909 3 COG3884 FatA, Acyl-ACP thioesterase Lipid metabolism 118468921 Common - urea amidolyase MSMEG_2187 113 COG1984 DUR1, Allophanate hydrolase subunit 2 Amino acid transport and metabolism 118472731 Common - cytochrome c oxidase subunit 2 MSMEG_4268 129 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 118468569 Common - short-chain dehydrogenase/reductase SDR MSMEG_6340 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118473850 Pathogen - hypothetical protein MSMEG_3736 1 None None None 118472676 Common - hypothetical protein MSMEG_5223 4 None None None 118469930 Common - pyridoxamine 5'-phosphate oxidase family protein MSMEG_0964 1 None None None 118472741 Common - serine/threonine-protein kinase PknD MSMEG_1190 151 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 118470617 Pathogen - hypothetical protein MSMEG_3918 1 None None None 118467423 Common - transcriptional regulator, XRE family protein MSMEG_2694 30 COG1396 HipB, Predicted transcriptional regulators Transcription 118472242 Common - hypothetical protein MSMEG_1333 20 COG3673 COG3673, Uncharacterized conserved protein Function unknown 118469321 Common - virulence factor Mce family protein MSMEG_1145 29 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118469560 Pathogen - hypothetical protein MSMEG_2709 1 None None None 118467531 Common - nitroreductase family protein MSMEG_6258 40 COG0778 NfnB, Nitroreductase Energy production and conversion 118470495 Common thrB homoserine kinase MSMEG_4955 70 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 118472406 Pathogen - transcriptional regulator, TetR family protein MSMEG_4964 1 COG1309 AcrR, Transcriptional regulator Transcription 118472218 Common - 5-carboxymethyl-2-hydroxymuconate delta-isomerase MSMEG_2382 180 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 118472165 Common - transcriptional repressor, TetR family protein, putative MSMEG_4825 25 COG1309 AcrR, Transcriptional regulator Transcription 118473778 Common - DNA-binding protein, putative MSMEG_6198 24 COG3835 CdaR, Sugar diacid utilization regulator Transcription / Signal transduction mechanisms 118473852 Common - TRAP transporter, DctM-like membrane protein MSMEG_3350 120 COG1593 DctQ, TRAP-type C4-dicarboxylate transport system, large permease component Carbohydrate transport and metabolism 118472380 Common - ABC-type nitrate/sulfonate/bicarbonate transport system ATPase component MSMEG_1160 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 118471556 Common - transketoloase, C half MSMEG_2166 223 COG3958 COG3958, Transketolase, C-terminal subunit Carbohydrate transport and metabolism 118470607 Common - amino acid permease MSMEG_0279 160 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118473973 Common - glutamyl-tRNA(Gln) amidotransferase subunit A MSMEG_0821 207 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 118473449 Common - hypothetical protein MSMEG_6914 19 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 118471208 Common - hypothetical protein MSMEG_2199 3 None None None 118471603 Common - MoaC domain protein MSMEG_4714 79 COG2030 MaoC, Acyl dehydratase Lipid metabolism 118472077 Common - immunogenic protein MPT63 MSMEG_0828 1 None None None 118469767 Common - [Mn] superoxide dismutase MSMEG_6427 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 118472009 Common bioA adenosylmethionine--8-amino-7-oxononanoate transaminase MSMEG_3188 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 118473790 Pathogen - hypothetical protein MSMEG_3133 1 None None None 118471719 Pathogen - hypothetical protein MSMEG_6460 1 None None None 118467972 Common - arabinose-proton symporter MSMEG_2004 102 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118468232 Common - trypsin domain protein MSMEG_6359 4 None None None 118473607 Common - ATPase component of ABC transporters with duplicated ATPase domains MSMEG_6748 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 118470425 Common - methoxy mycolic acid synthase 1 MSMEG_0913 127 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 118467772 Common - integral membrane protein MSMEG_0668 2 None None None 118470551 Common - hypothetical protein MSMEG_3714 5 None None None 118473813 Common - ABC transporter, permease protein SugB MSMEG_5059 205 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 118471901 Common - hypothetical protein MSMEG_4259 231 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 118470854 Common - putative conserved membrane protein MSMEG_0788 6 None None None 118470028 Common - hypothetical protein MSMEG_6475 5 None None None 118471292 Pathogen - hypothetical protein MSMEG_3295 1 None None None 118470935 Common - hypothetical protein MSMEG_5168 8 None None None 118472426 Pathogen - hypothetical protein MSMEG_1569 1 None None None 118470788 Common - cytochrome P450-terp MSMEG_2257 77 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118473585 Common oppC ABC transporter, permease protein OppC MSMEG_4996 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118471955 Common - IS1096, tnpA protein MSMEG_1258 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118473445 Common - acyl-coA-dehydrogenase MSMEG_0406 145 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118473177 Common - immunogenic protein MPB64/MPT64 MSMEG_2331 1 None None None 118467390 Common - sulfonate binding protein MSMEG_0550 110 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 118471368 Common thrS threonyl-tRNA synthetase MSMEG_2931 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 118470965 Common glf UDP-galactopyranose mutase MSMEG_6404 54 COG0562 Glf, UDP-galactopyranose mutase Cell envelope biogenesis, outer membrane 118471679 Common - hypothetical protein MSMEG_0053 14 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 118473451 Common - putative oxidoreductase MSMEG_6836 38 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 118469254 Common etfB electron transfer flavoprotein, beta subunit MSMEG_2351 153 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 118467895 Common - acetyl-/propionyl-coenzyme A carboxylase alpha chain MSMEG_5493 224 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 118472750 Common - inner membrane metabolite transport protein YdfJ MSMEG_3421 131 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118472660 Common - formate/nitrate transporter MSMEG_5360 86 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 118470080 Pathogen - hypothetical protein MSMEG_6093 1 None None None 118471860 Common - ABC transporter, membrane spanning protein MSMEG_4559 190 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 118473397 Common - acetyl-CoA acetyltransferase MSMEG_5996 177 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118470547 Common - putative transposase MSMEG_1725 7 None None None 118467842 Common - hypothetical protein MSMEG_4631 4 COG5403 COG5403, Uncharacterized conserved protein Function unknown 118472738 Common - IS1096, tnpA protein MSMEG_2828 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118471800 Common - methoxy mycolic acid synthase 1 MSMEG_1203 125 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 118467735 Common - hypothetical protein MSMEG_5817 18 None None None 118467807 Common - dihydropteroate synthase MSMEG_4047 59 COG1237 COG1237, Metal-dependent hydrolases of the beta-lactamase superfamily II General function prediction only 118469896 Common - MarR-family protein transcriptional regulator MSMEG_0188 20 COG1846 MarR, Transcriptional regulators Transcription 118468758 Pathogen - hypothetical protein MSMEG_4131 1 None None None 118467397 Pathogen - hypothetical protein MSMEG_4965 1 None None None 118468752 Common - DNA topoisomerase IV subunit B MSMEG_0457 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 118471259 Pathogen - hypothetical protein MSMEG_6166 1 None None None 118470204 Pathogen - hypothetical protein MSMEG_3698 1 None None None 118470803 Common - extra cytoplasmic sigma factor MSMEG_0405 42 COG4941 COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain Transcription 118469824 Common - IS3 family protein element, transposase orfA MSMEG_1716 42 None None None 118473219 Pathogen - hypothetical protein MSMEG_6898 1 None None None 118470973 Common mce methylmalonyl-CoA epimerase MSMEG_4921 94 COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins Amino acid transport and metabolism / General function prediction only 118470311 Common pqqC pyrroloquinoline quinone biosynthesis protein PqqC MSMEG_3723 40 COG5424 COG5424, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C Coenzyme metabolism 118469362 Common - methyltransferase MSMEG_1480 32 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 118471281 Common gpsI polynucleotide phosphorylase/polyadenylase MSMEG_2656 237 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 118469282 Common - ABC nitrate/sulfonate/bicarbonate transporter, ATPase subunit MSMEG_0551 243 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 118467518 Common - transcriptional regulator, XRE family protein MSMEG_0918 38 COG1396 HipB, Predicted transcriptional regulators Transcription 118470464 Common - enoyl-CoA hydratase/isomerase family protein MSMEG_6795 172 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118468305 Common - TetR-family protein transcriptional regulator MSMEG_0962 7 COG1309 AcrR, Transcriptional regulator Transcription 118471887 Common - Di-/tripeptide transporter MSMEG_3533 80 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 118472987 Common - PduO protein MSMEG_1544 77 COG3193 GlcG, Uncharacterized protein, possibly involved in utilization of glycolate and propanediol General function prediction only 118472191 Common - L-asparaginase MSMEG_3173 122 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 118472311 Common - hypothetical protein MSMEG_5202 5 None None None 118471845 Common - putative xylulose kinase MSMEG_1376 27 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 118472230 Common ltrA low temperature requirement protein LtrA MSMEG_4766 30 COG4292 COG4292, Predicted membrane protein Function unknown 118468466 Common - hypothetical protein MSMEG_5134 1 None None None 118470531 Common - putative acyl-CoA dehydrogenase MSMEG_5621 3 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472047 Common - GntR-family protein regulator MSMEG_6371 162 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 118469749 Common - 3-oxoacyl-[acyl-carrier-protein] reductase MSMEG_2852 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470136 Common - putative ECF sigma factor RpoE1 MSMEG_0573 154 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118470017 Common - oligopeptide transporter, OPT family protein MSMEG_1311 41 COG1297 COG1297, Predicted membrane protein Function unknown 118470615 Common msrB methionine-R-sulfoxide reductase MSMEG_2784 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 118471138 Common - undecaprenyl pyrophosphate phosphatase MSMEG_4194 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 118471716 Common - short-chain dehydrogenase/reductase SDR MSMEG_6823 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471900 Common - RNA polymerase sigma factor, sigma-70 family protein MSMEG_6817 47 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118473485 Common - IS1096, tnpA protein MSMEG_4403 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118472315 Common - GAF domain protein MSMEG_4044 44 COG3835 CdaR, Sugar diacid utilization regulator Transcription / Signal transduction mechanisms 118469670 Pathogen - hypothetical protein MSMEG_5195 1 None None None 118472291 Common - short chain dehydrogenase MSMEG_3426 233 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118468366 Common - putative IclR family protein transcriptional regulator MSMEG_4090 111 COG1414 IclR, Transcriptional regulator Transcription 118472946 Common rhaU L-rhamnose 1-epimerase MSMEG_0587 42 COG3254 COG3254, Uncharacterized conserved protein Function unknown 118472678 Pathogen - hypothetical protein MSMEG_6448 1 None None None 118472102 Pathogen - hypothetical protein MSMEG_2145 1 None None None 118470165 Common hypA hydrogenase nickel insertion protein HypA MSMEG_2722 92 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 118472779 Common - phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase MSMEG_6401 61 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 118468424 Common - O-methyltransferase, family protein 2 MSMEG_5354 44 None None None 118470107 Common cobT nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase MSMEG_4275 118 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 118472669 Common - hypothetical protein MSMEG_6143 7 None None None 118469656 Common rfbC dTDP-4-dehydrorhamnose 3,5-epimerase MSMEG_5977 163 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 118468071 Common - Fmt protein MSMEG_0393 152 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 118469965 Common - putative acyl-CoA dehydrogenase MSMEG_5622 153 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118472967 Common - sensor histidine kinase MtrB MSMEG_1875 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 118469784 Common - aldehyde dehydrogenase (NAD) family protein MSMEG_1665 221 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118473675 Common - hypothetical protein MSMEG_0977 4 None None None 118467370 Common - metallo-beta-lactamase family protein MSMEG_2975 214 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 118470622 Common ehuB ectoine/hydroxyectoine ABC transporter solute-binding protein MSMEG_5368 90 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 118468706 Common - translation initiation factor IF-2 protein MSMEG_0069 1 None None None 118470362 Common - FAD dependent oxidoreductase MSMEG_1153 32 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 118470597 Common cysA sulfate ABC transporter, ATP-binding protein MSMEG_4530 249 COG1118 CysA, ABC-type sulfate/molybdate transport systems, ATPase component Inorganic ion transport and metabolism 118469350 Common hutI imidazolonepropionase MSMEG_1182 98 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 118467489 Common - 2-dehydropantoate 2-reductase MSMEG_2919 36 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 118469273 Common - putative transcriptional regulator MSMEG_4331 92 COG0583 LysR, Transcriptional regulator Transcription 118473731 Common - short chain dehydrogenase MSMEG_3619 161 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118468487 Common - 3-alpha-hydroxysteroid dehydrogenase MSMEG_3704 173 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118467918 Common rbsR ribose operon repressor MSMEG_6798 128 COG1609 PurR, Transcriptional regulators Transcription 118470693 Common - Formyl transferase MSMEG_0014 217 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 118469219 Pathogen - hypothetical protein MSMEG_0689 1 None None None 118470010 Common - DNA-binding protein MSMEG_3976 18 COG1309 AcrR, Transcriptional regulator Transcription 118473930 Pathogen - hypothetical protein MSMEG_6472 1 None None None 118472373 Common - myo-inositol 2-dehydrogenase MSMEG_4666 174 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 118467686 Pathogen - hypothetical protein MSMEG_1079 2 None None None 118471356 Common - transporter, major facilitator family protein MSMEG_5693 9 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118467511 Pathogen - hypothetical protein MSMEG_1778 1 None None None 118469087 Common - hypothetical protein MSMEG_1312 1 COG5336 COG5336, Uncharacterized protein conserved in bacteria Function unknown 118468979 Common rpsR ribosomal protein S18 MSMEG_6065 208 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 118469757 Common - gamma-glutamylisopropylamide synthetase MSMEG_1116 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 118473915 Common - 5-oxovalerate dehydrogenase MSMEG_1461 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118469921 Common glpK glycerol kinase MSMEG_6759 178 COG0554 GlpK, Glycerol kinase Energy production and conversion 118467820 Common - MbtG protein MSMEG_4509 8 COG3486 IucD, Lysine/ornithine N-monooxygenase Secondary metabolites biosynthesis, transport, and catabolism 118470667 Common - N-succinyldiaminopimelate aminotransferase MSMEG_5121 236 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 118472721 Common manB phosphomannomutase/phosphoglucomutase MSMEG_1834 240 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 118471314 Common - MaoC like domain, putative MSMEG_5991 11 None None None 118472139 Common - Transcription factor WhiB MSMEG_1831 19 None None None 118473756 Pathogen - hypothetical protein MSMEG_5351 1 None None None 118468134 Common - hypothetical protein MSMEG_1357 6 None None None 118473748 Common - iron repressor protein MSMEG_2652 100 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 118469233 Common - hypothetical protein MSMEG_5322 1 None None None 118468187 Common - cyclic nucleotide-binding protein MSMEG_5458 77 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 118469373 Common - enoyl-CoA hydratase MSMEG_5495 176 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118470994 Common - hypothetical protein MSMEG_0625 4 COG1647 COG1647, Esterase/lipase General function prediction only 118471317 Pathogen - hypothetical protein MSMEG_3077 1 None None None 118469127 Common - transferase MSMEG_0422 102 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 118471759 Common - GntR-family protein transcriptional regulator MSMEG_4121 143 COG2186 FadR, Transcriptional regulators Transcription 118469905 Pathogen - hypothetical protein MSMEG_4500 1 None None None 118468718 Common - hypothetical protein MSMEG_5324 60 COG3176 COG3176, Putative hemolysin General function prediction only 118468384 Common - hypothetical protein MSMEG_2376 7 None None None 118473620 Common - oxidoreductase, 2OG-Fe(II) oxygenase family protein MSMEG_4007 53 COG3491 PcbC, Isopenicillin N synthase and related dioxygenases General function prediction only 118468217 Common - putative DNA-binding protein MSMEG_1626 41 COG1396 HipB, Predicted transcriptional regulators Transcription 118468174 Common - hypothetical protein MSMEG_3351 3 None None None 118470596 Common - hypothetical protein MSMEG_1960 1 None None None 118469584 Common - carbon monoxide dehydrogenase subunit G (CoxG) superfamily protein MSMEG_2455 31 COG3427 COG3427, Uncharacterized conserved protein Function unknown 118472514 Pathogen - hypothetical protein MSMEG_4838 1 None None None 118472049 Common - IS1096, tnpA protein MSMEG_5378 49 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 118467850 Common - tetratricopeptide repeat domain protein MSMEG_2267 16 None None None 118471700 Pathogen - hypothetical protein MSMEG_4026 1 None None None 118471149 Common - periplasmic binding proteins and sugar binding domain of the LacI family protein, putative MSMEG_6044 124 COG1609 PurR, Transcriptional regulators Transcription 118469864 Common - ABC transporter, inner membrane subunit MSMEG_6522 104 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 118468613 Common - hypothetical protein MSMEG_2643 10 COG4293 COG4293, Uncharacterized protein conserved in bacteria Function unknown 118470036 Common - hypothetical protein MSMEG_2763 19 None None None 118472691 Common - ECF-family protein RNA polymerase sigma factor MSMEG_1692 44 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 118472258 Common - acyl-CoA dehydrogenase MSMEG_5618 125 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118469857 Common - YaeQ protein MSMEG_3358 52 COG4681 COG4681, Uncharacterized protein conserved in bacteria Function unknown 118469359 Common - hypothetical protein MSMEG_0359 9 None None None 118468060 Common - ferredoxin-dependent glutamate synthase 1 MSMEG_6459 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 118469992 Common - amidohydrolase family protein MSMEG_6887 82 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 118468450 Common - D-ribose-binding periplasmic protein MSMEG_3095 112 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118468459 Pathogen - hypothetical protein MSMEG_2798 1 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 118467404 Common - quinone oxidoreductase MSMEG_4146 171 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118472550 Common - HAD-superfamily protein subfamily protein IB hydrolase, TIGR01490 MSMEG_0949 105 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 118473463 Common - hypothetical protein MSMEG_2307 82 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118471570 Common - virulence factor mce family protein MSMEG_2860 10 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118471851 Common - GAF domain, putative MSMEG_4553 7 COG2203 FhlA, FOG: GAF domain Signal transduction mechanisms 118471028 Common - enoyl-CoA hydratase MSMEG_3567 178 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118472253 Common - epoxide hydrolase MSMEG_6720 140 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118473540 Common pta phosphate acetyltransferase MSMEG_0783 178 COG0280 Pta, Phosphotransacetylase Energy production and conversion 118473450 Common - acyl-CoA synthetase MSMEG_4301 202 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118470480 Common - flavohemoprotein MSMEG_0719 86 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 118469058 Common purF amidophosphoribosyltransferase MSMEG_5800 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 118467849 Common - transcriptional regulator, AsnC family protein MSMEG_2660 139 COG1522 Lrp, Transcriptional regulators Transcription 118472875 Common - acyl-CoA thioesterase MSMEG_3812 77 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 118469068 Common recG ATP-dependent DNA helicase RecG MSMEG_2403 230 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 118472918 Common pknA serine/threonine protein kinase PknA MSMEG_0030 157 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 118472187 Common - caib/baif family protein MSMEG_1903 115 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 118472838 Common - regulatory protein MSMEG_6688 17 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 118473059 Common - probable antibiotic-transport integral membrane leucine and valine rich protein abc transporter MSMEG_1503 5 None None None 118470872 Common - hypothetical protein MSMEG_5540 3 None None None 118470303 Common - hypothetical protein MSMEG_1951 2 None None None 118470093 Common - chelatase MSMEG_2615 70 COG1239 ChlI, Mg-chelatase subunit ChlI Coenzyme metabolism 118472107 Pathogen - hypothetical protein MSMEG_1128 1 None None None 118469476 Common ssuD nitrilotriacetate monooxygenase component A MSMEG_4096 54 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118468526 Common - 3-ketoacyl-(acyl-carrier-protein) reductase MSMEG_2687 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470837 Pathogen - hypothetical protein MSMEG_5973 1 None None None 118468141 Common eda 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase MSMEG_3788 126 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 118468349 Pathogen - hypothetical protein MSMEG_1044 1 None None None 118473719 Common - coproporphyrinogen III oxidase MSMEG_4525 203 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 118471008 Common - MarR-family protein transcriptional regulator MSMEG_0207 59 COG1846 MarR, Transcriptional regulators Transcription 118470358 Common - permease of the major facilitator superfamily protein MSMEG_4721 59 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 118470918 Common - hypothetical protein MSMEG_5218 14 COG5485 COG5485, Predicted ester cyclase General function prediction only 118468971 Common - gas vesicle protein MSMEG_5746 6 None None None 118469635 Common - cyclase/dehydrase superfamily protein MSMEG_1287 1 None None None 118469835 Common ppk polyphosphate kinase MSMEG_2391 162 COG0855 Ppk, Polyphosphate kinase Inorganic ion transport and metabolism 118467847 Common - alpha/beta hydrolase, putative MSMEG_6586 133 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 118469264 Common - D-mannonate oxidoreductase MSMEG_5576 90 COG0246 MtlD, Mannitol-1-phosphate/altronate dehydrogenases Carbohydrate transport and metabolism 118472399 Common alr alanine racemase MSMEG_1575 199 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 118473253 Common ssuD nitrilotriacetate monooxygenase component A MSMEG_4086 48 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118472452 Common - inner membrane protein YidH MSMEG_1231 19 COG2149 COG2149, Predicted membrane protein Function unknown 118468876 Common - hypothetical protein MSMEG_0519 1 None None None 118470708 Common - hypothetical protein MSMEG_0736 5 None None None 118467558 Common - virulence factor mce family protein MSMEG_5895 31 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 118467954 Common - zinc-binding alcohol dehydrogenase family protein MSMEG_5164 146 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118468943 Common - short-chain dehydrogenase/reductase SDR MSMEG_6626 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118471306 Common - polyamine ABC-transporter, inner membrane subunit MSMEG_0658 141 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 118472729 Pathogen - hypothetical protein MSMEG_5133 1 None None None 118467800 Common - hypothetical protein MSMEG_1531 23 COG5516 COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding General function prediction only 118468872 Common - TrkA domain protein MSMEG_3665 24 COG0490 COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels Inorganic ion transport and metabolism 118473212 Common - hypothetical protein MSMEG_3942 57 COG2187 COG2187, Uncharacterized protein conserved in bacteria Function unknown 118472589 Common - mosc domain protein MSMEG_0146 20 COG3217 COG3217, Uncharacterized Fe-S protein General function prediction only 118472205 Common - zinc-binding alcohol dehydrogenase MSMEG_3306 190 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 118473372 Common - hydroxymethylglutaryl-CoA lyase MSMEG_2024 198 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 118470916 Common - short chain dehydrogenase MSMEG_3559 36 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118469077 Pathogen - hypothetical protein MSMEG_3344 1 None None None 118467607 Common - lipid-transfer protein MSMEG_5922 54 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118473245 Pathogen - hypothetical protein MSMEG_4314 1 None None None 118472001 Common - methyltransferase type 12, putative MSMEG_5975 37 None None None 118468480 Common - putative short chain dehydrogenase MSMEG_5869 140 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470489 Common - acyltransferase family protein MSMEG_6408 98 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 118471184 Common tatC twin arginine-targeting protein translocase TatC MSMEG_3886 203 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 118469752 Common - CalU12 protein MSMEG_4966 29 COG4312 COG4312, Uncharacterized protein conserved in bacteria Function unknown 118472690 Common selB selenocysteine-specific translation elongation factor MSMEG_1849 249 COG3276 SelB, Selenocysteine-specific translation elongation factor Translation, ribosomal structure and biogenesis 118467464 Common - nitrilotriacetate monooxygenase component A MSMEG_4085 53 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118469316 Common - beta-lactamase MSMEG_6822 9 COG2367 PenP, Beta-lactamase class A Defense mechanisms 118470521 Common - amidohydrolase family protein MSMEG_4807 14 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118471308 Common - hypothetical protein MSMEG_1342 22 COG2030 MaoC, Acyl dehydratase Lipid metabolism 118469133 Common - probable serine/threonine-protein kinase PknK MSMEG_0529 161 COG2909 MalT, ATP-dependent transcriptional regulator Transcription 118468098 Common - inositol monophosphate phosphatase MSMEG_3210 182 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 118473937 Common - amino acid permease-associated region, putative MSMEG_4549 78 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 118469538 Common - hydrolase MSMEG_3753 98 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 118470404 Common - branched-chain amino acid ABC transporter ATP-binding protein MSMEG_3251 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 118471535 Pathogen - hypothetical protein MSMEG_2701 1 None None None 118467695 Common - transporter, major facilitator family protein MSMEG_3316 35 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 118471513 Common - N-acyl-D-glutamate amidohydrolase MSMEG_1997 66 COG3653 COG3653, N-acyl-D-aspartate/D-glutamate deacylase Secondary metabolites biosynthesis, transport, and catabolism 118471529 Common - hydrolase, NUDIX family protein MSMEG_3198 64 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 118470045 Common - IolE protein MSMEG_4665 59 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 118473591 Common - conserved hypothetical proline rich protein MSMEG_0699 61 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 118469037 Common - RsbW protein MSMEG_1803 9 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 118468995 Common pqqB pyrroloquinoline quinone biosynthesis protein PqqB MSMEG_3724 34 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 118472842 Common - Hsp20/alpha crystallin family protein MSMEG_0424 53 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 118467701 Common - universal stress protein family protein MSMEG_3945 31 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 118469183 Common - hypothetical protein MSMEG_0080 1 None None None 118471865 Common - 3-oxoacyl-(acyl carrier protein) synthase II MSMEG_1204 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118468584 Common - hypothetical protein MSMEG_5087 135 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 118469025 Common - transcriptional regulator MSMEG_5566 34 COG1846 MarR, Transcriptional regulators Transcription 118473324 Pathogen - hypothetical protein MSMEG_5868 1 None None None 118472597 Common - probable transcriptional regulator YdhC MSMEG_6738 134 COG1802 GntR, Transcriptional regulators Transcription 118468237 Common - ftsk/spoiiie family protein MSMEG_0617 62 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 118469442 Common hypC hydrogenase assembly chaperone HypC/HupF MSMEG_2703 82 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 118472801 Pathogen - hypothetical protein MSMEG_3597 1 None None None 118473406 Common - glyoxalase/bleomycin resistance protein/dioxygenase MSMEG_2301 43 COG3607 COG3607, Predicted lactoylglutathione lyase General function prediction only 118472798 Pathogen - cytospin-A, putative MSMEG_5772 1 None None None 118468027 Pathogen - hypothetical protein MSMEG_3370 1 None None None 118473695 Common - [NADP+] succinate-semialdehyde dehydrogenase MSMEG_6452 222 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118472808 Pathogen - hypothetical protein MSMEG_3600 1 None None None 118468935 Common - transcriptional regulator, PadR family protein MSMEG_6227 78 COG1695 COG1695, Predicted transcriptional regulators Transcription 118472347 Common - membrane protein MSMEG_6372 12 COG2246 COG2246, Predicted membrane protein Function unknown 118468803 Common - BadF/BadG/BcrA/BcrD ATPase family protein MSMEG_0512 60 COG2971 COG2971, Predicted N-acetylglucosamine kinase Carbohydrate transport and metabolism 118469518 Common - hypothetical protein MSMEG_3019 31 COG4307 COG4307, Uncharacterized protein conserved in bacteria Function unknown 118470074 Common - hypothetical protein MSMEG_0413 1 None None None 118473065 Pathogen - hypothetical protein MSMEG_1202 1 None None None 118471914 Common aspS aspartyl-tRNA synthetase MSMEG_3003 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 118468151 Common tgt queuine tRNA-ribosyltransferase MSMEG_6313 230 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 118473948 Common - amidohydrolase 2 MSMEG_6813 38 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 118469794 Common - hypothetical proline-rich protein MSMEG_2088 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 118468711 Common - aldehyde dehydrogenase MSMEG_6491 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118473123 Common modA molybdate ABC transporter, periplasmic molybdate-binding protein MSMEG_2016 132 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 118473351 Common - acyl-CoA oxidase MSMEG_4474 109 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118468490 Common - hypothetical protein MSMEG_4502 141 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 118470217 Common serB phosphoserine phosphatase MSMEG_1041 157 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 118469742 Common - transcription elongation factor GreA MSMEG_6292 18 COG0782 GreA, Transcription elongation factor Transcription 118473285 Common - Bacterial extracellular solute-binding protein UspC MSMEG_4468 80 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 118468049 Common - alcohol dehydrogenase, zinc-containing MSMEG_1037 196 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 118471559 Common yajC preprotein translocase subunit YajC MSMEG_2960 30 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 118468592 Common fni isopentenyl-diphosphate delta-isomerase, type 2 MSMEG_1057 80 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 118468058 Common - hypothetical protein MSMEG_5081 16 None None None 118470472 Common - protease 2 MSMEG_5839 100 COG1770 PtrB, Protease II Amino acid transport and metabolism 118472715 Common - transcriptional regulator, LysR family protein MSMEG_6028 105 COG0583 LysR, Transcriptional regulator Transcription 118471439 Common - hypothetical protein MSMEG_2185 39 COG3665 COG3665, Uncharacterized conserved protein Function unknown 118470672 Common - acyl-CoA synthetase MSMEG_5435 214 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 118469712 Common - putative aliphatic sulfonates transport permease protein SsuC MSMEG_5530 181 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 118468252 Common hisF imidazole glycerol phosphate synthase subunit HisF MSMEG_3211 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 118467523 Common pstC phosphate ABC transporter, permease protein PstC MSMEG_5781 225 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 118469383 Common - 3-beta hydroxysteroid dehydrogenase/isomerase family protein MSMEG_5228 209 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118470841 Common - acetyl-CoA C-acyltransferase MSMEG_2224 173 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 118469944 Common - hypothetical protein MSMEG_2853 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 118471707 Common - hypothetical protein MSMEG_2503 12 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 118469049 Common - hypothetical protein MSMEG_2717 7 None None None 118469099 Common - serine/threonine dehydratase family protein MSMEG_3532 209 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 118473941 Common - MmpS2 protein MSMEG_3585 1 None None None 118468310 Common - hypothetical metabolite transport protein YaaU MSMEG_4078 123 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 118473743 Common - extradiol ring-cleavage dioxygenase, class III enzyme, subunit B MSMEG_0043 86 COG3384 COG3384, Uncharacterized conserved protein Function unknown 118474033 Common - hypothetical protein MSMEG_1877 4 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 118469003 Common - transcriptional regulator, sugar-binding family protein MSMEG_3092 70 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 118469374 Common - glutamate synthase, NADH/nadph, small subunit MSMEG_3226 200 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 118469480 Common - Fe uptake system permease MSMEG_6062 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 118473553 Common - nucleoside triphosphate pyrophosphohydrolase MSMEG_5422 152 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 118468340 Common - hypothetical protein MSMEG_0920 2 None None None 118473604 Common - inositol monophosphatase MSMEG_2083 191 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 118469044 Common - hypothetical protein MSMEG_1279 17 None None None 118467882 Pathogen - hypothetical protein MSMEG_1801 1 None None None 118467817 Common - aquaporin Z MSMEG_6466 134 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 118469567 Common prfA peptide chain release factor 1 MSMEG_4950 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 118471694 Pathogen - hypothetical protein MSMEG_3678 1 None None None 118467346 Common - glutamine ABC transporter periplasmic-binding protein MSMEG_0176 162 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 118467457 Common - NAD-dependent alcohol dehydrogenase MSMEG_3915 200 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 118467413 Common - ISMsm2, transposase MSMEG_5669 52 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 118474006 Common - hypothetical protein MSMEG_5741 53 COG1434 COG1434, Uncharacterized conserved protein Function unknown 118474032 Common - GntR-family protein transcriptional regulator MSMEG_5375 124 COG2186 FadR, Transcriptional regulators Transcription 118472040 Common - short chain dehydrogenase MSMEG_5584 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118467903 Common rfbB dTDP-glucose 4,6-dehydratase MSMEG_1512 230 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 118467921 Common ilvA threonine dehydratase MSMEG_3183 216 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 118469816 Common - response regulator MSMEG_3246 224 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 118473994 Common pyrG CTP synthetase MSMEG_3746 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 118473360 Common - hypothetical protein MSMEG_4962 104 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 118468871 Common - integral membrane protein MSMEG_2188 34 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 118468664 Common - hypothetical protein MSMEG_3355 60 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 118469165 Common - Alanine dehydrogenase/pyridine nucleotide transhydrogenase MSMEG_0152 166 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 118473616 Common - hypothetical protein MSMEG_6080 28 COG1623 COG1623, Predicted nucleic-acid-binding protein (contains the HHH domain) General function prediction only 118468983 Common - adenine phosphoribosyltransferase MSMEG_2964 165 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 118470893 Common - hypothetical protein MSMEG_0004 21 COG5512 COG5512, Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives General function prediction only 118472441 Common - DegV family protein MSMEG_4577 40 COG1307 DegV, Uncharacterized protein conserved in bacteria Function unknown 118471524 Common - 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase MSMEG_1109 87 COG1165 MenD, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Coenzyme metabolism 118470581 Common - spfh domain/band 7 family protein, putative MSMEG_1517 95 COG2268 COG2268, Uncharacterized protein conserved in bacteria Function unknown 118473575 Common - transcriptional regulator, TetR family protein domain protein, putative MSMEG_2368 8 COG1309 AcrR, Transcriptional regulator Transcription 118469557 Common - 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase MSMEG_3009 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118469403 Common - enoyl-CoA hydratase/isomerase family protein MSMEG_4775 172 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 118472686 Common - lipoprotein LpqH MSMEG_6316 3 None None None 118472869 Common - hydrolase, carbon-nitrogen family protein MSMEG_6733 195 COG0388 COG0388, Predicted amidohydrolase General function prediction only 118473359 Common gatC aspartyl/glutamyl-tRNA amidotransferase subunit C MSMEG_2364 44 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 118467594 Common - eptc-inducible aldehyde dehydrogenase MSMEG_1543 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 118470296 Common - MutT/nudix family protein MSMEG_3745 161 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 118473875 Common - transposase subunit MSMEG_6888 136 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 118470344 Common - dehydrogenase/reductase SDR family protein member 4 MSMEG_1740 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118470653 Common - adenosine kinase MSMEG_4270 66 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 118469052 Common ssuD nitrilotriacetate monooxygenase component A MSMEG_2843 60 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 118473968 Common - putative acyl-CoA dehydrogenase MSMEG_6041 134 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118468010 Common - transferase MSMEG_0184 144 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 118469985 Common - cobalt transport protein CbiM MSMEG_2608 4 None None None 118467729 Common - hypothetical protein MSMEG_4305 164 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 118471210 Common - integral membrane protein MSMEG_6442 4 None None None 118470323 Common - phosphoglycerate dehydrogenase MSMEG_6115 226 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 118471498 Common - cobalamin synthesis protein MSMEG_1123 127 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 118470636 Common - putative HTH-type transcriptional regulator MSMEG_6139 15 COG1309 AcrR, Transcriptional regulator Transcription 118467354 Common cobG precorrin-3B synthase MSMEG_3871 28 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 118468694 Pathogen - hypothetical protein MSMEG_4895 1 None None None 118470252 Common - YceI like family protein MSMEG_5125 118 COG2353 COG2353, Uncharacterized conserved protein Function unknown 118473521 Common - propane monooxygenase hydroxylase large subunit MSMEG_1971 19 None None None 118467931 Common mutA methylmalonyl-CoA mutase, small subunit MSMEG_3158 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 118473848 Common ruvC Holliday junction resolvase MSMEG_2943 193 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 118471686 Common - nitrate/nitrite response regulator protein MSMEG_2251 164 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 118471894 Common - hypothetical protein MSMEG_3361 4 None None None 118468057 Common - integral membrane protein MSMEG_0125 75 COG3333 COG3333, Uncharacterized protein conserved in bacteria Function unknown 118473337 Pathogen - hypothetical protein MSMEG_3353 1 None None None 118472856 Common - probable transcriptional regulatory protein MSMEG_1420 12 COG1309 AcrR, Transcriptional regulator Transcription 118473633 Common aroQ dehydroquinase dehydratase, type II MSMEG_2532 159 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 118470225 Common rplN ribosomal protein L14 MSMEG_1465 247 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 118470904 Common - ABC transporter permease protein MSMEG_1086 219 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118471893 Common - oxidoreductase MSMEG_1742 113 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 118472392 Common - oxidoreductase MSMEG_0811 7 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 118470685 Common - hypothetical protein MSMEG_3153 10 None None None 118472206 Pathogen - hypothetical protein MSMEG_4748 1 None None None 118472892 Common - cytochrome P450 monooxygenase MSMEG_1775 22 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 118473906 Common - repressor MSMEG_5575 58 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 118470259 Common map methionine aminopeptidase, type I MSMEG_5050 246 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 118470760 Common - pyridoxamine 5'-phosphate oxidase family protein MSMEG_5170 10 COG3871 COG3871, Uncharacterized stress protein (general stress protein 26) General function prediction only 118467863 Common - hypothetical protein MSMEG_6500 6 None None None 118474044 Common - hypothetical protein MSMEG_4636 1 None None None 118470023 Common - 3-hydroxyacyl-CoA dehydrogenase MSMEG_3005 148 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 118467383 Common - nitrile hydratase activator P14k MSMEG_0379 8 None None None 118467986 Common - hypothetical protein MSMEG_1988 3 None None None 118468226 Pathogen - hypothetical protein MSMEG_2977 1 None None None 118467447 Common zwf glucose-6-phosphate 1-dehydrogenase MSMEG_3101 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 118469458 Common - acyl-CoA dehydrogenase MSMEG_6584 139 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 118471267 Common cbiQ cobalt ABC transporter, permease protein CbiQ MSMEG_2609 51 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 118472832 Common - oleandomycin glycosyltransferase MSMEG_0730 50 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 118471995 Common - hypothetical protein MSMEG_0926 8 None None None 118467474 Common - transcriptional regulator, PadR family protein domain protein MSMEG_6226 40 COG1695 COG1695, Predicted transcriptional regulators Transcription 118470234 Common - ATP-dependent rna helicase, dead/deah box family protein MSMEG_5042 246 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 118473159 Common - MmgE/PrpD family protein MSMEG_6856 59 COG2079 PrpD, Uncharacterized protein involved in propionate catabolism General function prediction only 118472818 Common - serine esterase, cutinase family protein MSMEG_1184 3 None None None 118468444 Common - 2,3-dihydroxybenzoate-AMP ligase MSMEG_4516 220 COG1021 EntE, Peptide arylation enzymes Secondary metabolites biosynthesis, transport, and catabolism 118470579 Common murI glutamate racemase MSMEG_4903 190 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 118467810 Common - inner membrane ABC transporter permease protein YddQ MSMEG_4356 219 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 118470244 Common - bifunctional udp-galactofuranosyl transferase glft MSMEG_6403 20 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 118473911 Common lppH putative conserved lipoprotein lpph MSMEG_4598 1 None None None 118468699 Common - SseC protein MSMEG_5790 10 None None None 118472229 Common - putative conserved transmembrane protein MSMEG_0236 1 None None None 118471108 Pathogen - hypothetical protein MSMEG_4769 1 None None None 118471175 Common - 2-hydroxycyclohexnecarboxyl-CoA dehydrogenase MSMEG_0527 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118469143 Common - clavaldehyde dehydrogenase MSMEG_5569 233 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118471246 Common narI respiratory nitrate reductase, gamma subunit MSMEG_5137 58 COG2181 NarI, Nitrate reductase gamma subunit Energy production and conversion 118471729 Common - hypothetical protein MSMEG_5643 9 None None None 118471228 Common uvrA excinuclease ABC subunit A MSMEG_3808 237 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 118471432 Pathogen - hypothetical protein MSMEG_1966 1 None None None 118467815 Common - starvation-sensing protein RspA MSMEG_2909 112 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 118472482 Common - hypothetical protein MSMEG_1620 6 None None None 118472118 Common - MmsAB operon regulatory protein MSMEG_3998 133 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 118467377 Common - GntR-family protein regulator MSMEG_5760 164 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 118467563 Pathogen - hypothetical protein MSMEG_1619 1 None None None 118471221 Common - short chain dehydrogenase MSMEG_1073 205 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 118470726 Common - cyclopentanol dehydrogenase MSMEG_2477 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 118472211 Common - SpfH domain protein MSMEG_4576 207 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 118473953 Common - adenylate cyclase, family protein 3 MSMEG_4924 67 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 118470715 Common - hypothetical protein MSMEG_5213 5 None None None 118470797 Common - flavin-nucleotide-binding protein MSMEG_4975 26 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 118471270 Common - hypothetical protein MSMEG_3020 15 None None None 118467828 Common hydA dihydropyrimidinase MSMEG_3553 197 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 118471883 Common fdhD formate dehydrogenase accessory protein MSMEG_0165 137 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 118469189 Common - ribonuclease MSMEG_0208 25 COG4290 COG4290, Guanyl-specific ribonuclease Sa Nucleotide transport and metabolism 118471981 Pathogen - mucin-associated surface protein MSMEG_3256 1 None None None 118473500 Common - ComA operon protein 2 MSMEG_3628 71 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 118472126 Common - hypothetical protein MSMEG_4143 49 COG5470 COG5470, Uncharacterized conserved protein Function unknown 118467664 Common - ATP:cob(I)alamin adenosyltransferase MSMEG_4934 130 COG2096 COG2096, Uncharacterized conserved protein Function unknown 118468587 Common - selenophosphate synthetase MSMEG_0567 37 COG2144 COG2144, Selenophosphate synthetase-related proteins General function prediction only 118470004 Common hypE hydrogenase expression/formation protein HypE MSMEG_2276 132 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 118473978 Common - hypothetical protein MSMEG_4824 1 None None None 118473036 Common - regulatory protein, ArsR MSMEG_1125 18 COG2345 COG2345, Predicted transcriptional regulator Transcription 118468165 Common - integral membrane protein MSMEG_4292 37 COG2259 COG2259, Predicted membrane protein Function unknown 118469634 Common - short chain dehydrogenase MSMEG_1011 236 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 118471176 Pathogen - hypothetical protein MSMEG_5381 1 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 118468208 Common - transcriptional regulator, TetR family protein MSMEG_6537 79 COG1309 AcrR, Transcriptional regulator Transcription 118468401 Common - metallo-beta-lactamase family protein MSMEG_5638 92 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 118473147 Common pcaC 4-carboxymuconolactone decarboxylase domain protein MSMEG_3562 10 COG2128 COG2128, Uncharacterized conserved protein Function unknown 118472276 Common map methionine aminopeptidase MSMEG_1485 247 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 118470089 Common xth exodeoxyribonuclease III MSMEG_1656 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 118472433 Common - cyclopropane-fatty-acyl-phospholipid synthase MSMEG_6284 132 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 118467928 Common - hypothetical protein MSMEG_2288 7 None None None 118472015 Common - TetR-type regulator MSMEG_3807 18 COG1309 AcrR, Transcriptional regulator Transcription 118473318 Common - polysaccharide deacetylase MSMEG_1074 114 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 118473094 Common - UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MSMEG_4231 206 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane