Methanosaeta thermophila PT, complete genome NC_008553 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 116754159 Nonpathogen - hypothetical protein Mthe_0848 11 COG4090 COG4090, Uncharacterized protein conserved in archaea Function unknown 116754539 Common - geranylgeranylglyceryl phosphate synthase-like protein Mthe_1238 35 COG1646 COG1646, Predicted phosphate-binding enzymes, TIM-barrel fold General function prediction only 116753342 Nonpathogen - hypothetical protein Mthe_0017 9 None None None 116753697 Nonpathogen - hypothetical protein Mthe_0382 1 None None None 116754613 Common - CODH nickel-insertion accessory protein Mthe_1313 33 COG3640 CooC, CO dehydrogenase maturation factor Cell division and chromosome partitioning 116754201 Nonpathogen - hypothetical protein Mthe_0891 16 COG3388 COG3388, Uncharacterized protein conserved in archaea Function unknown 116754558 Common - aspartate carbamoyltransferase regulatory subunit Mthe_1257 65 COG1781 PyrI, Aspartate carbamoyltransferase, regulatory subunit Nucleotide transport and metabolism 116753810 Nonpathogen - hypothetical protein Mthe_0497 14 COG4050 COG4050, Uncharacterized protein conserved in archaea Function unknown 116755008 Nonpathogen - Ribonuclease P, Rpp29 Mthe_1720 24 COG1588 POP4, RNase P/RNase MRP subunit p29 Translation, ribosomal structure and biogenesis 116754350 Nonpathogen - response regulator receiver domain protein (CheY-like) Mthe_1044 9 None None None 116753574 Common - Alpha-amylase Mthe_0255 26 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 116755010 Common rps3p 30S ribosomal protein S3P Mthe_1722 248 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 116754591 Common - transcriptional regulator, ArsR family Mthe_1291 182 COG0640 ArsR, Predicted transcriptional regulators Transcription 116754642 Common - beta-lactamase domain protein Mthe_1345 139 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 116754876 Common - NADPH-dependent FMN reductase Mthe_1584 46 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 116754670 Common - protein of unknown function DUF101 Mthe_1373 41 COG1371 COG1371, Uncharacterized conserved protein Function unknown 116754684 Common - nitroreductase Mthe_1387 51 COG0778 NfnB, Nitroreductase Energy production and conversion 116754338 Nonpathogen - hypothetical protein Mthe_1032 1 None None None 116754131 Common - elongation factor EF-2 Mthe_0820 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 116754726 Common - Methyltransferase type 11 Mthe_1429 209 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116753881 Common - zinc transporter ZupT Mthe_0568 102 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 116753843 Common - ABC-2 type transporter Mthe_0530 188 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116754462 Common - hypothetical protein Mthe_1158 13 COG4744 COG4744, Uncharacterized conserved protein Function unknown 116753906 Nonpathogen - hypothetical protein Mthe_0593 6 COG1913 COG1913, Predicted Zn-dependent proteases General function prediction only 116754922 Nonpathogen - transcriptional regulator, XRE family Mthe_1633 11 COG4800 COG4800, Predicted transcriptional regulator with an HTH domain Transcription 116754843 Common - sulfate adenylyltransferase Mthe_1550 77 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 116753859 Nonpathogen - Methyl-coenzyme M reductase operon protein C Mthe_0546 14 COG4056 McrC, Methyl coenzyme M reductase, subunit C Coenzyme metabolism 116754443 Nonpathogen - zinc finger protein Mthe_1138 10 COG4855 COG4855, Uncharacterized protein conserved in archaea Function unknown 116755011 Common - ribosomal protein L22 Mthe_1723 50 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 116753669 Nonpathogen - hypothetical protein Mthe_0354 2 None None None 116754105 Common - pyruvate carboxylase subunit A Mthe_0794 225 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 116753388 Common - response regulator receiver protein Mthe_0064 224 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116754919 Nonpathogen - hypothetical protein Mthe_1630 1 None None None 116753612 Common - cobalamin biosynthesis protein CobD Mthe_0295 148 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 116753702 Nonpathogen - hypothetical protein Mthe_0387 1 None None None 116754162 Common - hypothetical protein Mthe_0851 13 None None None 116753443 Common - phosphoesterase, RecJ domain protein Mthe_0121 43 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 116754547 Common - dTMP kinase Mthe_1246 233 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 116754208 Common - histone acetyltransferase, ELP3 family Mthe_0898 115 COG1243 ELP3, Histone acetyltransferase Transcription / Chromatin structure and dynamics 116754931 Nonpathogen - preprotein translocase subunit SecG Mthe_1642 7 COG4023 SBH1, Preprotein translocase subunit Sec61beta Intracellular trafficking and secretion 116754421 Nonpathogen - hypothetical protein Mthe_1116 4 None None None 116753834 Common - binding-protein-dependent transport systems inner membrane component Mthe_0521 190 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 116754084 Nonpathogen - hypothetical protein Mthe_0772 1 None None None 116753784 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding Mthe_0471 35 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 116754679 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit B Mthe_1382 9 COG4062 MtrB, Tetrahydromethanopterin S-methyltransferase, subunit B Coenzyme metabolism 116754908 Common rps4p 30S ribosomal protein S4 Mthe_1619 196 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 116754898 Common - V-type ATP synthase subunit A Mthe_1609 247 COG1155 NtpA, Archaeal/vacuolar-type H+-ATPase subunit A Energy production and conversion 116754219 Common - Acetolactate decarboxylase Mthe_0909 40 COG3527 AlsD, Alpha-acetolactate decarboxylase Secondary metabolites biosynthesis, transport, and catabolism 116753710 Common - Betaine-aldehyde dehydrogenase Mthe_0395 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 116754850 Common - CRISPR-associated protein Cas4 Mthe_1558 53 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 116754068 Nonpathogen - protein of unknown function DUF1614 Mthe_0756 25 COG4089 COG4089, Predicted membrane protein Function unknown 116754877 Common - Imidazoleglycerol-phosphate dehydratase Mthe_1585 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 116754859 Nonpathogen - translation initiation factor IF-6 Mthe_1567 33 COG1976 TIF6, Translation initiation factor 6 (eIF-6) Translation, ribosomal structure and biogenesis 116754637 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Mthe_1340 161 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 116754470 Common - flavoprotein Mthe_1166 29 COG1036 COG1036, Archaeal flavoproteins Energy production and conversion 116754477 Common - thiamine biosynthesis protein ThiC Mthe_1173 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 116754119 Common - putative adenylyl cyclase CyaB Mthe_0808 34 COG1437 CyaB, Adenylate cyclase, class 2 (thermophilic) Nucleotide transport and metabolism 116754187 Common - Pyrrolo-quinoline quinone Mthe_0877 86 COG1520 COG1520, FOG: WD40-like repeat Function unknown 116754586 Nonpathogen - hypothetical protein Mthe_1286 3 COG2923 DsrF, Uncharacterized protein involved in the oxidation of intracellular sulfur Inorganic ion transport and metabolism 116754627 Nonpathogen - hypothetical protein Mthe_1329 13 COG4083 COG4083, Predicted membrane protein Function unknown 116754341 Common - binding-protein-dependent transport systems inner membrane component Mthe_1035 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 116754927 Common - Lysine exporter protein (LYSE/YGGA) Mthe_1638 31 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 116754494 Nonpathogen - hypothetical protein Mthe_1190 1 COG4068 COG4068, Uncharacterized protein containing a Zn-ribbon Function unknown 116753621 Common - putative signal transduction protein with CBS domains Mthe_0304 153 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 116754984 Nonpathogen - hypothetical protein Mthe_1696 4 None None None 116753452 Common - NADPH-dependent FMN reductase Mthe_0130 39 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 116753739 Nonpathogen - hypothetical protein Mthe_0425 1 None None None 116753740 Nonpathogen - hypothetical protein Mthe_0426 2 None None None 116754045 Common - thermosome Mthe_0733 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 116753470 Common - precorrin-8W decarboxylase Mthe_0148 44 COG2242 CobL, Precorrin-6B methylase 2 Coenzyme metabolism 116754325 Nonpathogen - putative nucleotidyltransferase Mthe_1018 30 COG2266 COG2266, GTP:adenosylcobinamide-phosphate guanylyltransferase Coenzyme metabolism 116754307 Common - histone deacetylase superfamily Mthe_1000 149 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 116754816 Common - putative small multi-drug export Mthe_1522 19 COG2426 COG2426, Predicted membrane protein Function unknown 116753473 Nonpathogen - hypothetical protein Mthe_0151 6 COG1503 eRF1, Peptide chain release factor 1 (eRF1) Translation, ribosomal structure and biogenesis 116753565 Nonpathogen - hypothetical protein Mthe_0246 1 None None None 116754050 Common - hypothetical protein Mthe_0738 35 None None None 116754417 Nonpathogen - Protein of unknown function DUF357 Mthe_1112 4 COG1849 COG1849, Uncharacterized protein conserved in archaea Function unknown 116754314 Nonpathogen - Domain of unknown function DUF1724 Mthe_1007 11 COG4742 COG4742, Predicted transcriptional regulator Transcription 116754650 Common - chorismate mutase Mthe_1353 24 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 116753776 Common - histone deacetylase superfamily Mthe_0463 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 116753819 Nonpathogen - hypothetical protein Mthe_0506 1 None None None 116754764 Common - dihydropteroate synthase Mthe_1468 217 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 116754274 Common - glycosyl transferase, family 2 Mthe_0964 50 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 116753393 Nonpathogen - hypothetical protein Mthe_0069 5 None None None 116753828 Common - major facilitator superfamily MFS_1 Mthe_0515 102 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116753576 Common - CMP/dCMP deaminase, zinc-binding Mthe_0257 117 COG2131 ComEB, Deoxycytidylate deaminase Nucleotide transport and metabolism 116753677 Nonpathogen - Translin Mthe_0362 24 COG2178 COG2178, Predicted RNA-binding protein of the translin family Translation, ribosomal structure and biogenesis 116754020 Nonpathogen - hypothetical protein Mthe_0708 1 None None None 116754090 Common - Alcohol dehydrogenase GroES domain protein Mthe_0778 205 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 116753850 Nonpathogen - hypothetical protein Mthe_0537 1 None None None 116753370 Common - Peptidylprolyl isomerase Mthe_0045 199 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 116754487 Common - hypothetical protein Mthe_1183 10 None None None 116753487 Common - GMP synthase subunit A Mthe_0166 240 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 116753588 Common - hypothetical protein Mthe_0269 13 None None None 116753381 Nonpathogen - hypothetical protein Mthe_0057 1 None None None 116753365 Nonpathogen - hypothetical protein Mthe_0040 1 None None None 116753946 Common - Phenylacetate--CoA ligase Mthe_0633 149 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 116754049 Nonpathogen - hypothetical protein Mthe_0737 5 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 116754910 Nonpathogen - RNA polymerase, insert Mthe_1621 38 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 116754008 Common - magnesium and cobalt transport protein CorA Mthe_0696 185 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 116753962 Common - CRISPR-associated RAMP protein, Cmr1 family Mthe_0650 10 COG1367 COG1367, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 116754029 Common - dihydropteroate synthase-related protein Mthe_0717 34 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 116753595 Common - Myo-inositol-1-phosphate synthase Mthe_0276 56 COG1260 INO1, Myo-inositol-1-phosphate synthase Lipid metabolism 116754001 Common - Rhodanese domain protein Mthe_0689 136 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 116754756 Common - DegT/DnrJ/EryC1/StrS aminotransferase Mthe_1460 194 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 116754152 Common - bifunctional inositol-1 monophosphatase/fructose-1,6-bisphosphatase Mthe_0841 201 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 116753497 Common gatB aspartyl/glutamyl-tRNA amidotransferase subunit B Mthe_0176 214 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 116753767 Common - Diaminopimelate epimerase Mthe_0454 203 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 116753431 Nonpathogen - hypothetical protein Mthe_0107 10 COG3377 COG3377, Uncharacterized conserved protein Function unknown 116754888 Common cobN cobaltochelatase Mthe_1598 89 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 116754562 Common - flavodoxin/nitric oxide synthase Mthe_1261 137 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 116753920 Nonpathogen - PUA domain containing protein Mthe_0607 6 COG1370 COG1370, Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit Posttranslational modification, protein turnover, chaperones 116754012 Nonpathogen - tRNA splicing endonuclease Mthe_0700 34 COG1676 SEN2, tRNA splicing endonuclease Translation, ribosomal structure and biogenesis 116754364 Common - proton-translocating NADH-quinone oxidoreductase, chain L Mthe_1058 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 116753407 Common - Proteasome endopeptidase complex Mthe_0083 49 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 116754285 Nonpathogen - Fe-S cluster domain protein Mthe_0978 10 COG1456 CdhE, CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) Energy production and conversion 116754460 Nonpathogen - hypothetical protein Mthe_1156 11 COG4827 COG4827, Predicted transporter General function prediction only 116754239 Common ileS isoleucyl-tRNA synthetase Mthe_0929 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116753590 Common - glycyl-tRNA synthetase Mthe_0271 86 COG0423 GRS1, Glycyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 116753529 Nonpathogen - hypothetical protein Mthe_0209 2 None None None 116753469 Common - cobalt-precorrin-2 C(20)-methyltransferase Mthe_0147 72 COG2243 CobF, Precorrin-2 methylase Coenzyme metabolism 116754648 Nonpathogen - glutamine amidotransferase class-I Mthe_1351 5 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 116754296 Common - tRNA pseudouridine synthase A Mthe_0989 237 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 116753797 Nonpathogen - transcriptional regulator, XRE family Mthe_0484 23 COG2522 COG2522, Predicted transcriptional regulator General function prediction only 116754749 Nonpathogen - Sjogrens syndrome scleroderma autoantigen 1 Mthe_1453 5 COG1645 COG1645, Uncharacterized Zn-finger containing protein General function prediction only 116754465 Common - chromosome segregation protein SMC Mthe_1161 197 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 116754747 Common - Tetratricopeptide TPR_2 repeat protein Mthe_1451 150 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116753467 Common - cobalamin biosynthesis protein CbiG Mthe_0145 95 COG2073 CbiG, Cobalamin biosynthesis protein CbiG Coenzyme metabolism 116753462 Nonpathogen - hypothetical protein Mthe_0140 5 COG4075 COG4075, Uncharacterized conserved protein, homolog of nitrogen regulatory protein PII Function unknown 116753515 Common - hypothetical protein Mthe_0194 25 COG4095 COG4095, Uncharacterized conserved protein Function unknown 116753899 Nonpathogen - hypothetical protein Mthe_0586 8 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 116754520 Nonpathogen - small GTP-binding protein Mthe_1219 15 COG1100 COG1100, GTPase SAR1 and related small G proteins General function prediction only 116754377 Common - Rhodanese domain protein Mthe_1071 115 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 116754202 Common - thiamine biosynthesis protein Mthe_0892 93 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 116754458 Common - Radical SAM domain protein Mthe_1154 192 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116753894 Common - deoxyribonuclease/rho motif-related TRAM Mthe_0581 28 COG3269 COG3269, Predicted RNA-binding protein, contains TRAM domain General function prediction only 116753752 Common - exsB protein Mthe_0438 159 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 116754754 Common - transferase hexapeptide repeat containing protein Mthe_1458 224 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 116753799 Nonpathogen - hypothetical protein Mthe_0486 1 None None None 116754702 Common - histone deacetylase superfamily Mthe_1405 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 116753410 Common - acetyl-CoA hydrolase/transferase Mthe_0086 152 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 116753987 Nonpathogen - tRNA adenylyltransferase Mthe_0675 34 COG1746 CCA1, tRNA nucleotidyltransferase (CCA-adding enzyme) Translation, ribosomal structure and biogenesis 116753417 Common - TGS domain protein Mthe_0093 40 COG1163 DRG, Predicted GTPase General function prediction only 116753643 Common - protein of unknown function UPF0016 Mthe_0327 72 COG2119 COG2119, Predicted membrane protein Function unknown 116753454 Nonpathogen - hypothetical protein Mthe_0132 12 COG3612 COG3612, Uncharacterized protein conserved in archaea Function unknown 116754175 Nonpathogen - peptidyl-tRNA hydrolase Mthe_0865 36 COG1990 COG1990, Uncharacterized conserved protein Function unknown 116753742 Common - periplasmic binding protein Mthe_0428 84 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 116753759 Common - ABC transporter related Mthe_0446 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 116753424 Nonpathogen - hypothetical protein Mthe_0100 1 None None None 116754309 Common - glutamyl-tRNA(Gln) amidotransferase subunit D Mthe_1002 136 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 116754394 Common - hypothetical protein Mthe_1089 106 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 116753537 Nonpathogen - hypothetical protein Mthe_0217 3 None None None 116754065 Nonpathogen - hypothetical protein Mthe_0753 1 None None None 116754254 Common - glycosyl transferase, family 4 Mthe_0944 185 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 116753997 Common - Superoxide dismutase Mthe_0685 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 116753623 Common - molybdenum cofactor synthesis domain Mthe_0306 179 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 116753542 Nonpathogen - hypothetical protein Mthe_0222 1 None None None 116754426 Common - putative thiazole biosynthetic enzyme Mthe_1121 31 COG1635 THI4, Flavoprotein involved in thiazole biosynthesis Coenzyme metabolism 116753700 Common - cobyric acid synthase Mthe_0385 152 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 116753901 Nonpathogen - hypothetical protein Mthe_0588 2 None None None 116753935 Common - phosphate ABC transporter, ATPase subunit Mthe_0622 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 116754603 Nonpathogen - hypothetical protein Mthe_1303 1 None None None 116754196 Nonpathogen - replication factor A Mthe_0886 26 COG1599 RFA1, Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins DNA replication, recombination, and repair 116753441 Nonpathogen - hypothetical protein Mthe_0119 1 None None None 116753886 Common - Radical SAM domain protein Mthe_0573 147 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116754942 Common - protein of unknown function DUF541 Mthe_1653 7 COG2968 COG2968, Uncharacterized conserved protein Function unknown 116754989 Nonpathogen - hypothetical protein Mthe_1701 1 None None None 116753568 Common - glutamine synthetase, type I Mthe_0249 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 116754789 Common pheT phenylalanyl-tRNA synthetase subunit beta Mthe_1495 240 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 116754955 Nonpathogen - tRNA 2'-O-methylase Mthe_1667 31 COG1303 COG1303, Uncharacterized protein conserved in archaea Function unknown 116753549 Nonpathogen - hypothetical protein Mthe_0229 1 None None None 116754476 Common - thiamine pyrophosphate enzyme domain protein TPP-binding Mthe_1172 89 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 116754837 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Mthe_1544 233 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 116754673 Common - Tetratricopeptide TPR_2 repeat protein Mthe_1376 112 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116753761 Common - periplasmic binding protein Mthe_0448 127 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 116753862 Common - Isocitrate dehydrogenase (NAD(+)) Mthe_0549 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 116754410 Nonpathogen - hypothetical protein Mthe_1105 4 None None None 116753337 Common - protein of unknown function UPF0153 Mthe_0012 25 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 116754689 Nonpathogen - protein of unknown function DUF35 Mthe_1392 40 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 116754824 Common - Methyltransferase type 11 Mthe_1530 178 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 116754624 Nonpathogen - Ribosomal protein S24e Mthe_1324 30 COG2004 RPS24A, Ribosomal protein S24E Translation, ribosomal structure and biogenesis 116754691 Common - DNA gyrase, A subunit Mthe_1394 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 116753489 Nonpathogen - hypothetical protein Mthe_0168 1 None None None 116753637 Common - beta-lactamase domain protein Mthe_0320 80 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 116754284 Common - tungsten formylmethanofuran dehydrogenase subunit B Mthe_0977 22 COG1029 FwdB, Formylmethanofuran dehydrogenase subunit B Energy production and conversion 116754777 Common - protein of unknown function DUF87 Mthe_1482 78 COG0433 COG0433, Predicted ATPase General function prediction only 116753581 Common rfc replication factor C small subunit Mthe_0262 249 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 116754086 Common - formylmethanofuran dehydrogenase subunit E-like Mthe_0774 31 COG2191 COG2191, Formylmethanofuran dehydrogenase subunit E Energy production and conversion 116754740 Nonpathogen - nucleic acid binding, OB-fold, tRNA/helicase-type Mthe_1444 14 COG3390 COG3390, Uncharacterized protein conserved in archaea Function unknown 116754404 Nonpathogen purP hypothetical protein Mthe_1099 20 COG1759 COG1759, ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases) General function prediction only 116754699 Common - TfuA domain protein, core Mthe_1402 25 COG3482 COG3482, Uncharacterized conserved protein Function unknown 116753709 Common - Radical SAM domain protein Mthe_0394 37 COG2516 COG2516, Biotin synthase-related enzyme General function prediction only 116754701 Common - Hydantoinase/oxoprolinase Mthe_1404 119 COG0145 HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116754102 Common - cytidyltransferase-related domain Mthe_0791 152 COG0615 TagD, Cytidylyltransferase Cell envelope biogenesis, outer membrane / Lipid metabolism 116754480 Common - threonyl-tRNA synthetase Mthe_1176 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116753482 Common - molybdenum cofactor synthesis domain Mthe_0160 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 116754126 Common - Protein of unknown function DUF1616 Mthe_0815 18 COG4743 COG4743, Predicted membrane protein Function unknown 116754806 Common - protein of unknown function DUF167 Mthe_1512 18 COG1872 COG1872, Uncharacterized conserved protein Function unknown 116754522 Nonpathogen - hypothetical protein Mthe_1221 13 COG3364 COG3364, Zn-ribbon containing protein General function prediction only 116753686 Common - hypothetical protein Mthe_0371 5 None None None 116754978 Common - conserved repeat domain Mthe_1690 31 None None None 116754518 Common - hypothetical protein Mthe_1217 27 None None None 116753650 Common - Nucleoside-diphosphate kinase Mthe_0334 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 116753375 Nonpathogen - hypothetical protein Mthe_0051 1 None None None 116754901 Common - V-type ATP synthase subunit E Mthe_1612 24 COG1390 NtpE, Archaeal/vacuolar-type H+-ATPase subunit E Energy production and conversion 116754269 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Mthe_0959 20 COG1035 FrhB, Coenzyme F420-reducing hydrogenase, beta subunit Energy production and conversion 116753556 Common - DHHA2 domain protein Mthe_0236 54 COG1227 PPX1, Inorganic pyrophosphatase/exopolyphosphatase Energy production and conversion 116754242 Nonpathogen - Protein of unknown function DUF131 Mthe_0932 1 None None None 116754392 Nonpathogen - hypothetical protein Mthe_1087 7 COG4014 COG4014, Uncharacterized protein conserved in archaea Function unknown 116754095 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding Mthe_0783 23 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 116754263 Common - dTDP-4-dehydrorhamnose reductase Mthe_0953 167 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 116753508 Nonpathogen - hypothetical protein Mthe_0187 7 COG3432 COG3432, Predicted transcriptional regulator Transcription 116753956 Common - hypothetical protein Mthe_0644 7 None None None 116754579 Common - Deoxyribonuclease V Mthe_1279 73 COG1515 Nfi, Deoxyinosine 3'endonuclease (endonuclease V) DNA replication, recombination, and repair 116754652 Nonpathogen - hypothetical protein Mthe_1355 1 None None None 116753904 Nonpathogen - hypothetical protein Mthe_0591 1 None None None 116754167 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Mthe_0857 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 116753357 Common - NusA family KH domain protein Mthe_0032 37 COG0195 NusA, Transcription elongation factor Transcription 116753672 Common - permease Mthe_0357 104 COG0701 COG0701, Predicted permeases General function prediction only 116754501 Common - formylmethanofuran dehydrogenase, subunit C (tungsten) Mthe_1198 97 COG2218 FwdC, Formylmethanofuran dehydrogenase subunit C Energy production and conversion 116754079 Common - triphosphoribosyl-dephospho-CoA protein Mthe_0767 32 COG1767 CitG, Triphosphoribosyl-dephospho-CoA synthetase Coenzyme metabolism 116754762 Common gltX glutamyl-tRNA synthetase Mthe_1466 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 116754665 Nonpathogen - Protein of unknown function DUF54 Mthe_1368 26 COG1325 COG1325, Predicted exosome subunit Translation, ribosomal structure and biogenesis 116754160 Common - phage shock protein A, PspA Mthe_0849 96 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 116754798 Common - adenylate kinases Mthe_1504 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 116753679 Common - ribose 5-phosphate isomerase Mthe_0364 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 116753836 Common - Radical SAM domain protein Mthe_0523 109 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116754677 Nonpathogen mtrF tetrahydromethanopterin S-methyltransferase subunit F Mthe_1380 7 COG4218 MtrF, Tetrahydromethanopterin S-methyltransferase, subunit F Coenzyme metabolism 116754962 Common - glycosyl transferase, family 2 Mthe_1674 34 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116754423 Common - alpha-L-glutamate ligases, RimK family Mthe_1118 144 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 116754891 Common - phosphoribosylaminoimidazole carboxylase related protein Mthe_1601 64 COG1691 COG1691, NCAIR mutase (PurE)-related proteins General function prediction only 116753614 Nonpathogen - hypothetical protein Mthe_0297 1 None None None 116754428 Common - Radical SAM domain protein Mthe_1123 140 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116753883 Nonpathogen - Methyl-coenzyme M reductase, gamma subunit Mthe_0570 14 COG4057 McrG, Methyl coenzyme M reductase, gamma subunit Coenzyme metabolism 116754498 Common - acetate--CoA ligase Mthe_1195 219 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 116754629 Common - CDP-diacylglycerol--serine O-phosphatidyltransferase Mthe_1331 151 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 116754835 Common - anthranilate synthase component I Mthe_1541 223 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 116754211 Common - Nucleotidyl transferase Mthe_0901 242 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 116754718 Common rpl1P 50S ribosomal protein L1P Mthe_1421 243 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 116753704 Common - protein of unknown function DUF87 Mthe_0389 94 COG0433 COG0433, Predicted ATPase General function prediction only 116753770 Nonpathogen - GvpD gas vesicle Mthe_0457 3 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 116754938 Common - protein of unknown function UPF0047 Mthe_1649 137 COG0432 COG0432, Uncharacterized conserved protein Function unknown 116754328 Common - metallophosphoesterase Mthe_1021 36 COG1407 COG1407, Predicted ICC-like phosphoesterases General function prediction only 116753426 Common - Sep-tRNA:Cys-tRNA synthetase Mthe_0102 111 COG1103 COG1103, Archaea-specific pyridoxal phosphate-dependent enzymes General function prediction only 116753712 Nonpathogen - TrkA-C domain protein Mthe_0397 7 COG0490 COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels Inorganic ion transport and metabolism 116753690 Common - Haloacid dehalogenase domain protein hydrolase Mthe_0375 112 COG4087 COG4087, Soluble P-type ATPase General function prediction only 116753344 Common - protein of unknown function DUF39 Mthe_0019 157 COG1900 COG1900, Uncharacterized conserved protein Function unknown 116754725 Common - NADPH-dependent F420 reductase Mthe_1428 36 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 116753664 Nonpathogen - hypothetical protein Mthe_0349 1 None None None 116753681 Common - translation initiation factor Sui1 Mthe_0366 85 COG0023 SUI1, Translation initiation factor 1 (eIF-1/SUI1) and related proteins Translation, ribosomal structure and biogenesis 116753812 Nonpathogen - hypothetical protein Mthe_0499 14 COG4070 COG4070, Predicted peptidyl-prolyl cis-trans isomerase (rotamase), cyclophilin family Posttranslational modification, protein turnover, chaperones 116754108 Common - glycosyl transferase, group 1 Mthe_0797 62 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116754541 Common - conserved hypothetical protein 341 Mthe_1240 52 COG1808 COG1808, Predicted membrane protein Function unknown 116754593 Nonpathogen - 30S ribosomal protein S8e Mthe_1293 34 COG2007 RPS8A, Ribosomal protein S8E Translation, ribosomal structure and biogenesis 116754871 Nonpathogen - hypothetical protein Mthe_1579 5 None None None 116753499 Common - glutamyl-tRNA(Gln) amidotransferase, C subunit Mthe_0178 166 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 116754548 Nonpathogen - hypothetical protein Mthe_1247 1 None None None 116754841 Nonpathogen - Oligosaccharyl transferase, STT3 subunit Mthe_1548 14 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 116754336 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Mthe_1029 229 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 116754483 Common - cobyrinic acid a,c-diamide synthase Mthe_1179 136 COG1797 CobB, Cobyrinic acid a,c-diamide synthase Coenzyme metabolism 116754590 Common - Rhodanese-related sulfurtransferase-like Mthe_1290 107 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 116753928 Nonpathogen - hypothetical protein Mthe_0615 1 None None None 116753675 Nonpathogen - protein of unknown function DUF54 Mthe_0360 22 COG1931 COG1931, Uncharacterized protein conserved in archaea Function unknown 116753806 Common - alkylhydroperoxidase like protein, AhpD family Mthe_0493 18 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 116753391 Common - transcriptional regulator, PadR-like family Mthe_0067 21 COG1695 COG1695, Predicted transcriptional regulators Transcription 116754382 Common - glycosyl transferase, family 2 Mthe_1077 221 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116753786 Common - beta-lactamase domain protein Mthe_0473 161 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 116754278 Nonpathogen - Methyltransferase type 12 Mthe_0968 2 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116753826 Common - FAD dependent oxidoreductase Mthe_0513 29 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 116754019 Common - glutaredoxin Mthe_0707 11 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 116754330 Common - transposase, IS4 family protein Mthe_1023 26 None None None 116753372 Common - putative transcriptional regulator, AsnC family Mthe_0047 59 COG1522 Lrp, Transcriptional regulators Transcription 116753964 Common - transposase, IS4 family protein Mthe_0652 26 None None None 116754022 Common thyA thymidylate synthase Mthe_0710 126 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 116753915 Common - UspA domain protein Mthe_0602 159 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 116753876 Nonpathogen - hypothetical protein Mthe_0563 1 None None None 116754143 Common - histidine triad (HIT) protein Mthe_0832 182 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 116754059 Common - large conductance mechanosensitive channel protein Mthe_0747 91 COG1970 MscL, Large-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 116754639 Nonpathogen - hypothetical protein Mthe_1342 11 COG4048 COG4048, Uncharacterized protein conserved in archaea Function unknown 116754432 Common - protein of unknown function DUF111 Mthe_1127 64 COG1641 COG1641, Uncharacterized conserved protein Function unknown 116753970 Nonpathogen - Protein of unknown function DUF504 Mthe_0658 2 COG1531 COG1531, Uncharacterized protein conserved in archaea Function unknown 116753852 Common - 3-dehydroquinate synthase Mthe_0539 28 COG1465 COG1465, Predicted alternative 3-dehydroquinate synthase Amino acid transport and metabolism 116754272 Nonpathogen - hypothetical protein Mthe_0962 1 None None None 116754092 Common - ribonuclease HII Mthe_0780 73 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 116754564 Common - histidinol-phosphate aminotransferase Mthe_1263 230 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 116753367 Common - acylphosphatase Mthe_0042 41 COG1254 AcyP, Acylphosphatases Energy production and conversion 116754300 Nonpathogen - 50S ribosomal protein L21e Mthe_0993 34 COG2139 RPL21A, Ribosomal protein L21E Translation, ribosomal structure and biogenesis 116754206 Common - preprotein translocase subunit SecF Mthe_0896 110 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 116753398 Nonpathogen - hypothetical protein Mthe_0074 3 None None None 116753520 Nonpathogen - Protein of unknown function DUF650 Mthe_0199 32 COG1602 COG1602, Uncharacterized conserved protein Function unknown 116754964 Common - glycosyl transferase, group 1 Mthe_1676 193 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116754047 Nonpathogen - hypothetical protein Mthe_0735 1 None None None 116753553 Nonpathogen - PUA domain containing protein Mthe_0233 34 COG2016 COG2016, Predicted RNA-binding protein (contains PUA domain) Translation, ribosomal structure and biogenesis 116754993 Common - preprotein translocase subunit SecY Mthe_1705 103 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 116754010 Common - AAA ATPase, central domain protein Mthe_0698 249 COG1223 COG1223, Predicted ATPase (AAA+ superfamily) General function prediction only 116753359 Common - 30S ribosomal protein S7P Mthe_0034 190 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 116754271 Common - glycosyl transferase, family 2 Mthe_0961 225 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116754770 Common - TPR repeat-containing protein Mthe_1474 126 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116754319 Nonpathogen - hypothetical protein Mthe_1012 34 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 116754312 Nonpathogen - hypothetical protein Mthe_1005 4 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 116753746 Common - ABC transporter related Mthe_0432 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 116754260 Common - acylphosphatases-like Mthe_0950 29 COG1254 AcyP, Acylphosphatases Energy production and conversion 116753993 Common - ABC transporter related Mthe_0681 241 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 116753979 Nonpathogen - hypothetical protein Mthe_0667 1 COG3175 COX11, Cytochrome oxidase assembly factor Posttranslational modification, protein turnover, chaperones 116754117 Nonpathogen - hypothetical protein Mthe_0806 25 COG2042 COG2042, Uncharacterized conserved protein Function unknown 116753779 Nonpathogen - hypothetical protein Mthe_0466 1 None None None 116753350 Common - 3-isopropylmalate dehydrogenase Mthe_0025 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 116753695 Common - aldolase Mthe_0380 80 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 116754409 Common - ABC-3 protein Mthe_1104 186 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 116754986 Nonpathogen - hypothetical protein Mthe_1698 21 COG1326 COG1326, Uncharacterized archaeal Zn-finger protein General function prediction only 116754052 Nonpathogen - hypothetical protein Mthe_0740 1 None None None 116753475 Common - peptidase U32 Mthe_0153 138 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 116754874 Common - Ion transport 2 domain protein Mthe_1582 93 None None None 116754917 Nonpathogen - hypothetical protein Mthe_1628 1 None None None 116754958 Common - ABC transporter related Mthe_1670 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116754415 Nonpathogen - hypothetical protein Mthe_1110 1 None None None 116754584 Nonpathogen - hypothetical protein Mthe_1284 2 None None None 116753563 Nonpathogen - hypothetical protein Mthe_0244 13 COG4033 COG4033, Uncharacterized protein conserved in archaea Function unknown 116754779 Common - SMC domain protein Mthe_1484 130 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 116754861 Nonpathogen rpl39e 50S ribosomal protein L39e Mthe_1569 29 COG2167 RPL39, Ribosomal protein L39E Translation, ribosomal structure and biogenesis 116754808 Nonpathogen - hypothetical protein Mthe_1514 1 None None None 116754682 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit E Mthe_1385 14 COG4059 MtrE, Tetrahydromethanopterin S-methyltransferase, subunit E Coenzyme metabolism 116754814 Nonpathogen - TOPRIM domain protein Mthe_1520 13 COG1658 COG1658, Small primase-like proteins (Toprim domain) DNA replication, recombination, and repair 116753918 Common - protein of unknown function DUF169 Mthe_0605 27 COG2043 COG2043, Uncharacterized protein conserved in archaea Function unknown 116754920 Common - heat shock protein Hsp20 Mthe_1631 163 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 116753348 Nonpathogen - Transcription factor Mthe_0023 24 COG2036 HHT1, Histones H3 and H4 Chromatin structure and dynamics 116754451 Nonpathogen - hypothetical protein Mthe_1147 6 None None None 116754641 Nonpathogen - hypothetical protein Mthe_1344 1 None None None 116754708 Common - FAD dependent oxidoreductase Mthe_1411 83 COG2509 COG2509, Uncharacterized FAD-dependent dehydrogenases General function prediction only 116754668 Nonpathogen - hypothetical protein Mthe_1371 14 COG4065 COG4065, Uncharacterized protein conserved in archaea Function unknown 116753616 Common - LOR/SDH bifunctional enzyme conserved domain protein Mthe_0299 33 COG1915 COG1915, Uncharacterized conserved protein Function unknown 116754124 Common - hypothetical protein Mthe_0813 58 COG3174 COG3174, Predicted membrane protein Function unknown 116754389 Nonpathogen - hypothetical protein Mthe_1084 5 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 116753780 Common - Radical SAM domain protein Mthe_0467 101 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 116754783 Common - phosphoesterase, RecJ domain protein Mthe_1489 28 COG1107 COG1107, Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain DNA replication, recombination, and repair 116754819 Nonpathogen - hypothetical protein Mthe_1525 5 COG1933 COG1933, Archaeal DNA polymerase II, large subunit DNA replication, recombination, and repair 116754857 Nonpathogen - prefoldin subunit alpha Mthe_1565 25 COG1730 GIM5, Predicted prefoldin, molecular chaperone implicated in de novo protein folding Posttranslational modification, protein turnover, chaperones 116754231 Nonpathogen - hypothetical protein Mthe_0921 1 None None None 116754445 Nonpathogen - hypothetical protein Mthe_1140 1 None None None 116753999 Common - CoA-binding domain protein Mthe_0687 117 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 116754916 Nonpathogen - hypothetical protein Mthe_1627 1 None None None 116753726 Common - ribose-phosphate pyrophosphokinase Mthe_0412 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 116753510 Common - beta-lactamase domain protein Mthe_0189 118 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 116754739 Nonpathogen - replication factor A Mthe_1443 18 COG1599 RFA1, Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins DNA replication, recombination, and repair 116754380 Common - Methyltransferase type 11 Mthe_1074 56 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116754034 Nonpathogen - DNA primase Mthe_0722 34 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 116754769 Nonpathogen - Protein of unknown function DUF166 Mthe_1473 8 COG1810 COG1810, Uncharacterized protein conserved in archaea Function unknown 116753438 Nonpathogen - hypothetical protein Mthe_0116 2 None None None 116754553 Common - phosphoribosylaminoimidazole synthetase Mthe_1252 234 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 116753535 Nonpathogen - hypothetical protein Mthe_0215 1 None None None 116754067 Common - NADPH-dependent FMN reductase Mthe_0755 46 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 116753540 Nonpathogen - Protein of unknown function UPF0179 Mthe_0220 22 COG1860 COG1860, Uncharacterized protein conserved in archaea Function unknown 116754302 Nonpathogen - Protein of unknown function DUF655 Mthe_0995 33 COG1491 COG1491, Predicted RNA-binding protein Translation, ribosomal structure and biogenesis 116754362 Nonpathogen - F(420)H(2) dehydrogenase, subunit FpoJ Mthe_1056 1 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 116753333 Nonpathogen - hypothetical protein Mthe_0008 9 None None None 116754237 Common - ribonuclease Z Mthe_0927 123 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 116753765 Common - 5-carboxymethyl-2-hydroxymuconate delta-isomerase Mthe_0452 181 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 116753404 Common - ATP phosphoribosyltransferase Mthe_0080 214 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 116754248 Nonpathogen - hypothetical protein Mthe_0938 19 COG1458 COG1458, Predicted DNA-binding protein containing PIN domain General function prediction only 116753405 Nonpathogen - hypothetical protein Mthe_0081 1 None None None 116753841 Common - periplasmic binding protein Mthe_0528 114 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 116753522 Common - Radical SAM domain protein Mthe_0202 51 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116754940 Common - FAD linked oxidase domain protein Mthe_1651 201 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 116753504 Nonpathogen - hypothetical protein Mthe_0183 2 COG1470 COG1470, Predicted membrane protein Function unknown 116753459 Nonpathogen - hypothetical protein Mthe_0137 19 COG2512 COG2512, Uncharacterized membrane-associated protein/domain Function unknown 116753465 Common - Precorrin-8X methylmutase CbiC/CobH Mthe_0143 119 COG2082 CobH, Precorrin isomerase Coenzyme metabolism 116754720 Nonpathogen nusG transcription antitermination protein NusG Mthe_1423 34 COG0250 NusG, Transcription antiterminator Transcription 116753750 Nonpathogen - putative transcriptional regulators, CopG/Arc/MetJ family Mthe_0436 7 COG3609 COG3609, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain Transcription 116753485 Common - NADPH-dependent FMN reductase Mthe_0163 68 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 116753457 Common - lysine 2,3-aminomutase YodO family protein Mthe_0135 127 COG1509 KamA, Lysine 2,3-aminomutase Amino acid transport and metabolism 116754881 Common - methylated-DNA--protein-cysteine methyltransferase Mthe_1589 181 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 116754241 Nonpathogen - Protein of unknown function DUF131 Mthe_0931 4 COG2034 COG2034, Predicted membrane protein Function unknown 116754864 Nonpathogen - 30S ribosomal protein S19e Mthe_1572 34 COG2238 RPS19A, Ribosomal protein S19E (S16A) Translation, ribosomal structure and biogenesis 116753517 Common - transposase, IS4 family protein Mthe_0196 26 None None None 116754527 Nonpathogen - hypothetical protein Mthe_1226 1 None None None 116754293 Common - DNA ligase domain protein Mthe_0986 33 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 116753635 Common - CBS domain containing protein Mthe_0318 166 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 116754145 Common - Periplasmic component of the Tol biopolymer transport system-like Mthe_0834 82 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116753897 Nonpathogen - transcriptional regulator, TrmB Mthe_0584 4 COG2512 COG2512, Uncharacterized membrane-associated protein/domain Function unknown 116754781 Nonpathogen - hypothetical protein Mthe_1487 1 None None None 116754537 Nonpathogen - hypothetical protein Mthe_1236 2 None None None 116754516 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Mthe_1215 48 COG2768 COG2768, Uncharacterized Fe-S center protein General function prediction only 116753628 Nonpathogen - hypothetical protein Mthe_0311 31 COG1936 COG1936, Predicted nucleotide kinase (related to CMP and AMP kinases) Nucleotide transport and metabolism 116754508 Nonpathogen - hypothetical protein Mthe_1205 2 None None None 116754089 Nonpathogen - hypothetical protein Mthe_0777 1 None None None 116754250 Common - UbiD family decarboxylases Mthe_0940 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 116754129 Common - phosphoesterase, RecJ domain protein Mthe_0818 40 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 116753688 Common - MiaB-like tRNA modifying enzyme Mthe_0373 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 116754006 Nonpathogen - PUA domain containing protein Mthe_0694 31 COG1370 COG1370, Prefoldin, molecular chaperone implicated in de novo protein folding, alpha subunit Posttranslational modification, protein turnover, chaperones 116754491 Common - dienelactone hydrolase Mthe_1187 40 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116755009 Nonpathogen - ribosomal protein L29 Mthe_1721 13 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 116753579 Common - Phenylacetate--CoA ligase Mthe_0260 134 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 116754135 Nonpathogen - hypothetical protein Mthe_0824 3 None None None 116753377 Common - hypothetical protein Mthe_0053 16 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 116754259 Common - acylphosphatases-like Mthe_0949 32 COG1254 AcyP, Acylphosphatases Energy production and conversion 116754848 Common - hypothetical protein Mthe_1556 8 None None None 116754097 Nonpathogen - hypothetical protein Mthe_0786 1 None None None 116753902 Common - undecaprenyl diphosphate synthase Mthe_0589 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 116753530 Nonpathogen - hypothetical protein Mthe_0210 3 None None None 116754481 Nonpathogen - S-layer-related duplication domain Mthe_1177 3 None None None 116753326 Common - quinolinate synthetase complex, A subunit Mthe_0001 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 116753656 Common - putative signal-transduction protein with CBS domains Mthe_0340 155 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 116753490 Nonpathogen - translation initiation factor eIF-1A Mthe_0169 34 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 116754267 Common - hypothetical protein Mthe_0957 4 None None None 116753944 Nonpathogen - hypothetical protein Mthe_0631 1 None None None 116754697 Nonpathogen - hypothetical protein Mthe_1400 3 None None None 116754166 Common - isopropylmalate/isohomocitrate dehydrogenases Mthe_0855 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 116753804 Common - arginine biosynthesis bifunctional protein ArgJ Mthe_0491 167 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 116754615 Common - PHP C-terminal domain protein Mthe_1315 91 COG1796 POL4, DNA polymerase IV (family X) DNA replication, recombination, and repair 116754198 Common metG methionyl-tRNA synthetase Mthe_0888 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116754529 Common - daunorubicin resistance ABC transporter ATPase subunit Mthe_1228 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116754080 Common - protein of unknown function DUF447 Mthe_0768 22 COG2457 COG2457, Uncharacterized conserved protein Function unknown 116753335 Common - molybdopterin biosynthesis MoaE Mthe_0010 163 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 116753674 Nonpathogen - peptide chain release factor 1 Mthe_0359 34 COG1503 eRF1, Peptide chain release factor 1 (eRF1) Translation, ribosomal structure and biogenesis 116753506 Common - sugar phosphate isomerase involved in capsule formation-like Mthe_0185 36 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 116754605 Common - orotate phosphoribosyltransferase Mthe_1305 80 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 116753937 Nonpathogen - protein of unknown function DUF115 Mthe_0624 30 COG1634 COG1634, Uncharacterized Rossmann fold enzyme General function prediction only 116753864 Common - hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha subunit Mthe_0551 148 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 116753603 Common - Radical SAM domain protein Mthe_0284 83 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 116754282 Common - ornithine carbamoyltransferase Mthe_0975 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 116753645 Nonpathogen - hypothetical protein Mthe_0329 1 None None None 116754571 Common - sodium/hydrogen exchanger Mthe_1271 205 COG4651 RosB, Kef-type K+ transport system, predicted NAD-binding component Inorganic ion transport and metabolism 116754646 Nonpathogen - hypothetical protein Mthe_1349 1 None None None 116753888 Common - PP-loop domain protein Mthe_0575 176 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 116754467 Common - glutamate synthase (NADPH), homotetrameric Mthe_1163 238 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 116753547 Common - MscS Mechanosensitive ion channel Mthe_0227 177 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 116754687 Common - hypothetical protein Mthe_1390 103 COG3425 PksG, 3-hydroxy-3-methylglutaryl CoA synthase Lipid metabolism 116753871 Common - Radical SAM domain protein Mthe_0558 233 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116754926 Common - phosphoenolpyruvate synthase Mthe_1637 236 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 116753448 Common - protein of unknown function DUF116 Mthe_0126 30 COG1852 COG1852, Uncharacterized conserved protein Function unknown 116753955 Nonpathogen - CRISPR-associated protein, Csx3 family Mthe_0643 4 None None None 116754829 Nonpathogen - hypothetical protein Mthe_1535 1 None None None 116754474 Common - PBS lyase HEAT domain protein repeat-containing protein Mthe_1170 34 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 116754822 Nonpathogen - hypothetical protein Mthe_1528 1 None None None 116754406 Common - hypothetical protein Mthe_1101 13 COG5418 COG5418, Predicted secreted protein Function unknown 116754953 Common - formylmethanofuran dehydrogenase, subunit E region Mthe_1665 39 COG2191 COG2191, Formylmethanofuran dehydrogenase subunit E Energy production and conversion 116754440 Common - Radical SAM domain protein Mthe_1135 176 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116753977 Nonpathogen - protein of unknown function DUF1646 Mthe_0665 11 COG4756 COG4756, Predicted cation transporter General function prediction only 116753925 Nonpathogen - transcriptional regulator, ArsR family Mthe_0612 17 COG1777 COG1777, Predicted transcriptional regulators Transcription 116753735 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Mthe_0421 198 COG0388 COG0388, Predicted amidohydrolase General function prediction only 116753931 Common - methyltransferase FkbM family Mthe_0618 35 COG2519 GCD14, tRNA(1-methyladenosine) methyltransferase and related methyltransferases Translation, ribosomal structure and biogenesis 116754632 Nonpathogen - hypothetical protein Mthe_1334 1 None None None 116754041 Nonpathogen - hypothetical protein Mthe_0729 1 None None None 116754317 Common - MscS Mechanosensitive ion channel Mthe_1010 212 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 116754667 Nonpathogen - hypothetical protein Mthe_1370 1 COG2219 PRI2, Eukaryotic-type DNA primase, large subunit DNA replication, recombination, and repair 116754384 Common - NAD-dependent epimerase/dehydratase Mthe_1079 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116754833 Common - anthranilate phosphoribosyltransferase Mthe_1539 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 116753731 Nonpathogen rps27e 30S ribosomal protein S27e Mthe_0417 34 COG2051 RPS27A, Ribosomal protein S27E Translation, ribosomal structure and biogenesis 116754270 Common - polysaccharide pyruvyl transferase Mthe_0960 24 COG2327 WcaK, Uncharacterized conserved protein Function unknown 116754980 Nonpathogen - conserved hypothetical protein 374 Mthe_1692 12 COG0392 COG0392, Predicted integral membrane protein Function unknown 116754582 Common - Cna B domain protein Mthe_1282 7 None None None 116754561 Nonpathogen - hypothetical protein Mthe_1260 1 None None None 116753521 Common - Radical SAM domain protein Mthe_0201 108 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116754345 Common - transposase Mthe_1039 24 COG5421 COG5421, Transposase DNA replication, recombination, and repair 116753790 Common - hypothetical protein Mthe_0477 69 COG1355 COG1355, Predicted dioxygenase General function prediction only 116754811 Common - integral membrane sensor signal transduction histidine kinase Mthe_1517 222 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 116754654 Nonpathogen - prefoldin, beta subunit Mthe_1357 32 COG1382 GimC, Prefoldin, chaperonin cofactor Posttranslational modification, protein turnover, chaperones 116754310 Common - phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Mthe_1003 215 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 116754083 Nonpathogen - von Willebrand factor, type A Mthe_0771 13 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 116754435 Nonpathogen - hypothetical protein Mthe_1130 1 None None None 116754647 Nonpathogen - hypothetical protein Mthe_1350 1 None None None 116754809 Common - putative small multi-drug export Mthe_1515 19 COG2426 COG2426, Predicted membrane protein Function unknown 116754017 Common - phosphate ABC transporter, inner membrane subunit PstC Mthe_0705 231 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 116754620 Nonpathogen - Nucleotide binding protein, PINc Mthe_1320 24 COG1412 COG1412, Uncharacterized proteins of PilT N-term./Vapc superfamily General function prediction only 116753610 Nonpathogen - acetyl-CoA decarbonylase/synthase complex subunit epsilon Mthe_0291 9 COG1880 CdhB, CO dehydrogenase/acetyl-CoA synthase epsilon subunit Energy production and conversion 116754717 Nonpathogen rplP0 acidic ribosomal protein P0 Mthe_1420 33 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 116753548 Common - DEAD/DEAH box helicase domain protein Mthe_0228 92 COG1111 MPH1, ERCC4-like helicases DNA replication, recombination, and repair 116753913 Common - DNA topoisomerase VI subunit A Mthe_0600 34 COG1697 COG1697, DNA topoisomerase VI, subunit A DNA replication, recombination, and repair 116754024 Nonpathogen - hypothetical protein Mthe_0712 8 None None None 116754459 Common - Phosphoribosyl-AMP cyclohydrolase Mthe_1155 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 116754146 Common - Cobaltochelatase Mthe_0835 89 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 116753386 Common - gas vesicle synthesis protein GvpA Mthe_0062 22 None None None 116754412 Common - permease Mthe_1107 86 COG0701 COG0701, Predicted permeases General function prediction only 116754397 Common - putative molybdenum cofactor biosynthesis protein C Mthe_1092 196 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 116754752 Common - ABC transporter related Mthe_1456 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 116754566 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Mthe_1265 158 COG2768 COG2768, Uncharacterized Fe-S center protein General function prediction only 116754335 Nonpathogen - DNA primase large subunit Mthe_1028 24 COG2219 PRI2, Eukaryotic-type DNA primase, large subunit DNA replication, recombination, and repair 116753361 Common - daunorubicin resistance ABC transporter ATPase subunit Mthe_0036 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116753586 Common - Nucleolar GTP-binding 1 Mthe_0267 213 COG1084 COG1084, Predicted GTPase General function prediction only 116754136 Common - dihydrodipicolinate reductase Mthe_0825 218 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 116754342 Common - binding-protein-dependent transport systems inner membrane component Mthe_1036 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 116754507 Common - ABC transporter tungsten-binding protein Mthe_1204 63 COG2998 TupB, ABC-type tungstate transport system, permease component Coenzyme metabolism 116754277 Common - transposase Mthe_0967 39 None None None 116753328 Common - RNA 3'-terminal-phosphate cyclase Mthe_0003 47 COG0430 RCL1, RNA 3'-terminal phosphate cyclase RNA processing and modification 116754355 Nonpathogen - hypothetical protein Mthe_1049 1 None None None 116754005 Common - PP-loop domain protein Mthe_0693 67 COG1606 COG1606, ATP-utilizing enzymes of the PP-loop superfamily General function prediction only 116753789 Common - mevalonate kinase Mthe_0476 53 COG1577 ERG12, Mevalonate kinase Lipid metabolism 116753847 Nonpathogen - phosphoesterase, putative Mthe_0534 35 COG1407 COG1407, Predicted ICC-like phosphoesterases General function prediction only 116753967 Nonpathogen - hypothetical protein Mthe_0655 13 COG4749 COG4749, Uncharacterized protein conserved in archaea Function unknown 116754936 Common - pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit Mthe_1647 62 COG1144 COG1144, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit Energy production and conversion 116754281 Nonpathogen - hypothetical protein Mthe_0973 1 None None None 116754595 Nonpathogen - hypothetical protein Mthe_1295 3 None None None 116754088 Common - ABC-3 protein Mthe_0776 174 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 116754543 Common - Methenyltetrahydrofolate cyclohydrolase Mthe_1242 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 116754998 Nonpathogen rpl19e 50S ribosomal protein L19e Mthe_1710 34 COG2147 RPL19A, Ribosomal protein L19E Translation, ribosomal structure and biogenesis 116753764 Common - oxidoreductase FAD/NAD(P)-binding domain protein Mthe_0451 108 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 116754674 Common - protein of unknown function UPF0153 Mthe_1377 8 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 116753722 Common - response regulator receiver protein Mthe_0407 123 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 116754076 Common - PHP C-terminal domain protein Mthe_0764 34 COG1379 COG1379, Uncharacterized conserved protein Function unknown 116754037 Nonpathogen - hypothetical protein Mthe_0725 1 None None None 116755004 Nonpathogen - 30S ribosomal protein S4e Mthe_1716 34 COG1471 RPS4A, Ribosomal protein S4E Translation, ribosomal structure and biogenesis 116754073 Nonpathogen - coenzyme M methyltransferase subunit X Mthe_0761 14 COG4002 COG4002, Predicted phosphotransacetylase General function prediction only 116753724 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) Mthe_0409 198 COG0281 SfcA, Malic enzyme Energy production and conversion 116755014 Common - Ribosomal protein L25/L23 Mthe_1726 55 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 116753839 Common - glycosyl transferase, group 1 Mthe_0526 226 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116753440 Common - Ferritin, Dps family protein Mthe_0118 81 COG1528 Ftn, Ferritin-like protein Inorganic ion transport and metabolism 116755015 Nonpathogen rpl4lp 50S ribosomal protein L4P Mthe_1727 34 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 116753714 Common - drug resistance transporter, Bcr/CflA subfamily Mthe_0399 220 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116753830 Common - oxidoreductase FAD/NAD(P)-binding domain protein Mthe_0517 169 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 116753447 Nonpathogen - protein of unknown function DUF1614 Mthe_0125 26 COG4089 COG4089, Predicted membrane protein Function unknown 116753684 Common - signal recognition particle protein Srp54 Mthe_0369 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 116753803 Common - putative signal transduction protein with CBS domains Mthe_0490 173 COG0517 COG0517, FOG: CBS domain General function prediction only 116754212 Nonpathogen - hypothetical protein Mthe_0902 5 COG3432 COG3432, Predicted transcriptional regulator Transcription 116754617 Nonpathogen - hypothetical protein Mthe_1317 1 None None None 116753694 Common - ATPase, P-type (transporting), HAD superfamily, subfamily IC Mthe_0379 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 116753615 Common - hypothetical protein Mthe_0298 30 COG4912 COG4912, Predicted DNA alkylation repair enzyme DNA replication, recombination, and repair 116754258 Common - acylphosphatase Mthe_0948 41 COG1254 AcyP, Acylphosphatases Energy production and conversion 116753396 Common - Gas vesicle K Mthe_0072 16 None None None 116754204 Common - Radical SAM domain protein Mthe_0894 77 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116753666 Common - Polyprenyl synthetase Mthe_0351 242 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 116754320 Nonpathogen - hypothetical protein Mthe_1013 7 COG1110 COG1110, Reverse gyrase DNA replication, recombination, and repair 116754732 Nonpathogen - hypothetical protein Mthe_1435 1 None None None 116753655 Common - metallophosphoesterase Mthe_0339 28 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 116754904 Common - H(+)-transporting ATP synthase, subunit H Mthe_1615 17 None None None 116753878 Common - Cobyrinic acid a,c-diamide synthase Mthe_0565 44 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 116754154 Common hisD histidinol dehydrogenase Mthe_0843 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 116753982 Nonpathogen - ribosomal protein S6e Mthe_0670 34 COG2125 RPS6A, Ribosomal protein S6E (S10) Translation, ribosomal structure and biogenesis 116753352 Common - DNA-directed RNA polymerase subunit beta'' Mthe_0027 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 116754944 Nonpathogen - DNA-binding protein Alba Mthe_1656 28 COG1581 Ssh10b, Archaeal DNA-binding protein Transcription 116754796 Common - Prephenate dehydrogenase Mthe_1502 144 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 116754245 Common - beta-ribofuranosylaminobenzene 5'-phosphate synthase family Mthe_0935 45 COG1907 COG1907, Predicted archaeal sugar kinases General function prediction only 116753809 Common - putative CoA-substrate-specific enzyme activase Mthe_0496 64 COG1924 COG1924, Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) Lipid metabolism 116754860 Nonpathogen - Ribosomal protein L31e Mthe_1568 32 COG2097 RPL31A, Ribosomal protein L31E Translation, ribosomal structure and biogenesis 116754472 Nonpathogen - hypothetical protein Mthe_1168 3 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 116754820 Common - protein of unknown function DUF167 Mthe_1526 18 COG1872 COG1872, Uncharacterized conserved protein Function unknown 116753551 Nonpathogen rpl37e 50S ribosomal protein L37e Mthe_0231 29 COG2126 RPL37A, Ribosomal protein L37E Translation, ribosomal structure and biogenesis 116754712 Nonpathogen - hypothetical protein Mthe_1415 2 None None None 116754280 Common - periplasmic binding protein Mthe_0972 87 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 116754846 Common - putative circadian clock protein, KaiC Mthe_1553 35 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 116753640 Common - major facilitator superfamily MFS_1 Mthe_0323 227 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116753524 Common - protein of unknown function DUF62 Mthe_0204 74 COG1912 COG1912, Uncharacterized conserved protein Function unknown 116753609 Common - acetyl-CoA decarbonylase/synthase complex subunit beta Mthe_0290 19 COG1614 CdhC, CO dehydrogenase/acetyl-CoA synthase beta subunit Energy production and conversion 116754329 Common - hypothetical protein Mthe_1022 26 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 116753602 Nonpathogen - hypothetical protein Mthe_0283 8 COG3270 COG3270, Uncharacterized conserved protein Function unknown 116754375 Nonpathogen - hypothetical protein Mthe_1069 1 None None None 116753824 Common - Cobyrinic acid a,c-diamide synthase Mthe_0511 125 COG3640 CooC, CO dehydrogenase maturation factor Cell division and chromosome partitioning 116753745 Common - transport system permease protein Mthe_0431 191 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 116754226 Common - thermosome Mthe_0916 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 116753653 Nonpathogen - hypothetical protein Mthe_0337 4 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 116753647 Nonpathogen rpl7ae 50S ribosomal protein L7Ae Mthe_0331 34 COG1358 RPL8A, Ribosomal protein HS6-type (S12/L30/L7a) Translation, ribosomal structure and biogenesis 116754656 Nonpathogen - DNA-directed RNA polymerase subunit P Mthe_1359 13 COG1996 RPC10, DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger) Transcription 116754183 Nonpathogen - hypothetical protein Mthe_0873 1 None None None 116754098 Common - Nitrous oxidase accessory protein-like Mthe_0787 50 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 116753953 Common - CRISPR-associated helicase Cas3 Mthe_0641 72 COG1203 COG1203, Predicted helicases General function prediction only 116754003 Common - redox-active disulfide protein 2 Mthe_0691 65 None None None 116753873 Common - Dinitrogenase iron-molybdenum cofactor biosynthesis Mthe_0560 27 COG1433 COG1433, Uncharacterized conserved protein Function unknown 116754793 Common - undecaprenyl diphosphate synthase Mthe_1499 239 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 116753682 Common - Na+/solute symporter Mthe_0367 95 COG4145 PanF, Na+/panthothenate symporter Coenzyme metabolism 116754304 Common - cytochrome c biogenesis protein, transmembrane region Mthe_0997 3 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 116754946 Common - histidine triad (HIT) protein Mthe_1658 104 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 116754192 Nonpathogen - hypothetical protein Mthe_0882 3 COG4098 comFA, Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) DNA replication, recombination, and repair 116753379 Nonpathogen - Gas vesicle synthesis GvpLGvpF Mthe_0055 8 None None None 116753626 Common - Na+/solute symporter Mthe_0309 191 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 116753866 Nonpathogen - hypothetical protein Mthe_0553 17 COG2454 COG2454, Uncharacterized conserved protein Function unknown 116753916 Common - amidohydrolase Mthe_0603 143 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 116753992 Common - Pyridoxal-5'-phosphate-dependent enzyme, beta subunit Mthe_0680 40 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 116754147 Common - periplasmic binding protein Mthe_0836 71 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 116754785 Nonpathogen - hypothetical protein Mthe_1491 1 None None None 116754400 Nonpathogen - molydopterin dinucleotide-binding region Mthe_1095 14 COG1153 FwdD, Formylmethanofuran dehydrogenase subunit D Energy production and conversion 116754951 Common - metal dependent phosphohydrolase Mthe_1663 86 COG1078 COG1078, HD superfamily phosphohydrolases General function prediction only 116754827 Common aksA trans-homoaconitate synthase Mthe_1533 214 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 116754995 Nonpathogen rpl30p 50S ribosomal protein L30P Mthe_1707 34 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 116754479 Nonpathogen - hypothetical protein Mthe_1175 1 None None None 116754974 Nonpathogen - translation initiation factor IF-5A Mthe_1686 34 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 116754104 Common - biotin--acetyl-CoA-carboxylase ligase Mthe_0793 225 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 116753633 Nonpathogen - hypothetical protein Mthe_0316 3 None None None 116753689 Nonpathogen - hypothetical protein Mthe_0374 1 None None None 116753941 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Mthe_0628 54 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 116753814 Common - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Mthe_0501 152 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 116753412 Nonpathogen - hypothetical protein Mthe_0088 1 None None None 116754112 Common - aminotransferase, class I and II Mthe_0801 239 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 116754514 Common - type I restriction-modification system specificity subunit Mthe_1213 52 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 116753608 Common - Cobyrinic acid a,c-diamide synthase Mthe_0289 31 COG3640 CooC, CO dehydrogenase maturation factor Cell division and chromosome partitioning 116753419 Nonpathogen - Protein of unknown function DUF516 Mthe_0095 27 COG1650 COG1650, Uncharacterized protein conserved in archaea Function unknown 116753455 Common - geranylgeranyl reductase Mthe_0133 88 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 116754039 Common - NAD+ synthetase Mthe_0727 229 COG0171 NadE, NAD synthase Coenzyme metabolism 116753338 Common - Phenylacetate--CoA ligase Mthe_0013 135 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 116754555 Common carB carbamoyl phosphate synthase large subunit Mthe_1254 236 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 116754165 Nonpathogen - hypothetical protein Mthe_0854 10 None None None 116754246 Common - hydroxymethylglutaryl-CoA reductase, degradative Mthe_0936 64 COG1257 HMG1, Hydroxymethylglutaryl-CoA reductase Lipid metabolism 116754358 Common - NADH dehydrogenase (ubiquinone) Mthe_1052 191 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 116753498 Common - glutamyl-tRNA(Gln) amidotransferase, A subunit Mthe_0177 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 116753436 Common - ketol-acid reductoisomerase Mthe_0112 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 116754490 Common - transport system permease protein Mthe_1186 192 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 116754469 Nonpathogen - Protein of unknown function DUF63 Mthe_1165 19 COG1967 COG1967, Predicted membrane protein Function unknown 116753460 Nonpathogen - Like-Sm ribonucleoprotein, core Mthe_0138 19 COG1958 LSM1, Small nuclear ribonucleoprotein (snRNP) homolog Transcription 116754221 Common - HhH-GPD family protein Mthe_0911 238 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 116753511 Common - AAA ATPase, central domain protein Mthe_0190 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 116753861 Nonpathogen - protein of unknown function RIO1 Mthe_0548 34 COG0478 COG0478, RIO-like serine/threonine protein kinase fused to N-terminal HTH domain Signal transduction mechanisms 116754525 Common - D-3-phosphoglycerate dehydrogenase Mthe_1224 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 116754464 Common - chromosome segregation and condensation protein ScpA Mthe_1160 28 COG1354 COG1354, Uncharacterized conserved protein Function unknown 116754015 Common - small GTP-binding protein Mthe_0703 168 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 116753502 Nonpathogen rpl10e 50S ribosomal protein L10e Mthe_0181 34 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 116753895 Nonpathogen - hypothetical protein Mthe_0582 1 None None None 116754807 Nonpathogen - TOPRIM domain protein Mthe_1513 13 COG1658 COG1658, Small primase-like proteins (Toprim domain) DNA replication, recombination, and repair 116753331 Nonpathogen - methyltransferase small Mthe_0006 30 COG2263 COG2263, Predicted RNA methylase Translation, ribosomal structure and biogenesis 116754576 Common - ATP-NAD/AcoX kinase Mthe_1276 26 COG3199 COG3199, Uncharacterized conserved protein Function unknown 116754207 Common - nitroreductase Mthe_0897 101 COG0778 NfnB, Nitroreductase Energy production and conversion 116753543 Common - PilT protein domain protein Mthe_0223 82 COG1855 COG1855, ATPase (PilT family) General function prediction only 116754683 Nonpathogen - hypothetical protein Mthe_1386 32 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 116753892 Common - cobalt transport protein CbiN Mthe_0579 34 COG1930 CbiN, ABC-type cobalt transport system, periplasmic component Inorganic ion transport and metabolism 116753909 Common - peptidase U62, modulator of DNA gyrase Mthe_0596 170 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 116754062 Common - phosphoribosyltransferase Mthe_0750 27 COG2236 COG2236, Predicted phosphoribosyltransferases General function prediction only 116753399 Nonpathogen - hypothetical protein Mthe_0075 1 None None None 116753591 Nonpathogen - hypothetical protein Mthe_0272 4 None None None 116754456 Common - uridylate kinase, putative Mthe_1152 217 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 116754534 Nonpathogen - Helix-turn-helix, type 11 domain protein Mthe_1233 22 COG1497 COG1497, Predicted transcriptional regulator Transcription 116753719 Nonpathogen - hypothetical protein Mthe_0404 10 COG4738 COG4738, Predicted transcriptional regulator Transcription 116753961 Common - CRISPR-associated protein, Crm2 family Mthe_0649 23 COG1353 COG1353, Predicted hydrolase of the HD superfamily (permuted catalytic motifs) General function prediction only 116754948 Common - tRNA-guanine transglycosylases, various specificities Mthe_1660 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 116753763 Common - dihydroorotate dehydrogenase 1B Mthe_0450 220 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 116754140 Nonpathogen - hypothetical protein Mthe_0829 1 None None None 116753463 Common - cobalt-precorrin-6Y C(5)-methyltransferase Mthe_0141 51 COG2241 CobL, Precorrin-6B methylase 1 Coenzyme metabolism 116753950 Common - CRISPR-associated protein, TM1802 family Mthe_0638 13 None None None 116753756 Common - transport system permease protein Mthe_0443 191 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 116754743 Common - phosphoribulokinase/uridine kinase Mthe_1447 96 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 116754722 Common - histone deacetylase superfamily Mthe_1425 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 116753561 Common - aspartate dehydrogenase Mthe_0242 49 COG1712 COG1712, Predicted dinucleotide-utilizing enzyme General function prediction only 116754171 Common - Ion transport protein Mthe_0861 101 None None None 116754127 Nonpathogen - hypothetical protein Mthe_0816 1 None None None 116754869 Nonpathogen - hypothetical protein Mthe_1577 2 None None None 116754178 Common - hypothetical protein Mthe_0868 13 COG1510 COG1510, Predicted transcriptional regulators Transcription 116753707 Common - ribosomal-protein-alanine acetyltransferase Mthe_0392 109 COG0456 RimI, Acetyltransferases General function prediction only 116754121 Nonpathogen - hypothetical protein Mthe_0810 4 None None None 116754644 Common - Citrate transporter Mthe_1347 145 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 116753534 Nonpathogen - hypothetical protein Mthe_0214 9 COG4004 COG4004, Uncharacterized protein conserved in archaea Function unknown 116754737 Common - phosphoesterase, RecJ domain protein Mthe_1441 71 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 116754707 Common - multiple antibiotic resistance (MarC)-related proteins Mthe_1410 159 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 116753749 Common - periplasmic binding protein Mthe_0435 80 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 116753428 Common - sirohydrochlorin cobaltochelatase Mthe_0104 53 COG2138 COG2138, Uncharacterized conserved protein Function unknown 116753802 Common argC N-acetyl-gamma-glutamyl-phosphate reductase Mthe_0489 214 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 116754292 Nonpathogen - Protein of unknown function DUF1119 Mthe_0985 15 COG3389 COG3389, Uncharacterized protein conserved in archaea Function unknown 116754257 Nonpathogen - hypothetical protein Mthe_0947 1 None None None 116753453 Nonpathogen - hypothetical protein Mthe_0131 1 None None None 116753539 Common egsA NAD(P)-dependent glycerol-1-phosphate dehydrogenase Mthe_0219 114 COG0371 GldA, Glycerol dehydrogenase and related enzymes Energy production and conversion 116753445 Common - seryl-tRNA synthetase Mthe_0123 9 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 116754750 Nonpathogen - hypothetical protein Mthe_1454 28 COG1698 COG1698, Uncharacterized protein conserved in archaea Function unknown 116754485 Common - Nucleotidyl transferase Mthe_1181 236 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 116754913 Common - thiamine pyrophosphate enzyme domain protein TPP-binding Mthe_1624 35 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 116754924 Nonpathogen - diphthamide biosynthesis protein Mthe_1635 34 COG1736 DPH2, Diphthamide synthase subunit DPH2 Translation, ribosomal structure and biogenesis 116754150 Common - aspartate/glutamate/uridylate kinase Mthe_0839 22 COG2054 COG2054, Uncharacterized archaeal kinase related to aspartokinases, uridylate kinases General function prediction only 116754349 Common - adenylylsulfate kinase Mthe_1043 145 COG0529 CysC, Adenylylsulfate kinase and related kinases Inorganic ion transport and metabolism 116753624 Nonpathogen - hypothetical protein Mthe_0307 1 None None None 116753550 Common - amidophosphoribosyltransferase Mthe_0230 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 116754399 Nonpathogen - hypothetical protein Mthe_1094 4 None None None 116754026 Common - geranylgeranyl reductase Mthe_0714 91 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 116754419 Common - protein of unknown function DUF355 Mthe_1114 33 COG1839 COG1839, Uncharacterized conserved protein Function unknown 116753584 Nonpathogen tfb transcription initiation factor IIB Mthe_0265 34 COG1405 SUA7, Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB Transcription 116754715 Common - protein of unknown function DUF81 Mthe_1418 10 COG0730 COG0730, Predicted permeases General function prediction only 116753617 Nonpathogen - ATP dependent DNA ligase Mthe_0300 19 COG1423 COG1423, ATP-dependent DNA ligase, homolog of eukaryotic ligase III DNA replication, recombination, and repair 116753439 Common - Rubredoxin-type Fe(Cys)4 protein Mthe_0117 124 COG1773 COG1773, Rubredoxin Energy production and conversion 116753363 Nonpathogen - hypothetical protein Mthe_0038 1 None None None 116754353 Common - Tubulin/FtsZ domain protein Mthe_1047 144 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 116753340 Common - UspA domain protein Mthe_0015 130 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 116754987 Common - protein-L-isoaspartate O-methyltransferase Mthe_1699 173 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 116753837 Nonpathogen - hypothetical protein Mthe_0524 1 None None None 116754568 Nonpathogen - hypothetical protein Mthe_1267 14 COG4022 COG4022, Uncharacterized protein conserved in archaea Function unknown 116754971 Common - transcriptional regulator, TrmB Mthe_1683 37 COG1378 COG1378, Predicted transcriptional regulators Transcription 116754634 Nonpathogen - 4Fe-4S ferredoxin, iron-sulfur binding Mthe_1337 5 None None None 116753798 Common - hypothetical protein Mthe_0485 6 None None None 116754758 Common - DOMON domain protein Mthe_1462 15 COG4902 COG4902, Uncharacterized protein conserved in archaea Function unknown 116753969 Common alaS alanyl-tRNA synthetase Mthe_0657 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116753733 Nonpathogen - hypothetical protein Mthe_0419 8 COG1711 COG1711, Uncharacterized protein conserved in archaea Function unknown 116754055 Common - Rubrerythrin Mthe_0743 80 COG1592 COG1592, Rubrerythrin Energy production and conversion 116753933 Nonpathogen - phosphate uptake regulator, PhoU Mthe_0620 29 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 116754189 Common - transcriptional regulator, AsnC family Mthe_0879 124 COG1522 Lrp, Transcriptional regulators Transcription 116754690 Common - DNA gyrase, B subunit Mthe_1393 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 116754831 Nonpathogen - protein of unknown function DUF114 Mthe_1537 32 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 116754327 Nonpathogen - hypothetical protein Mthe_1020 8 None None None 116754818 Common - integral membrane sensor signal transduction histidine kinase Mthe_1524 222 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 116753737 Nonpathogen - hypothetical protein Mthe_0423 1 None None None 116754043 Common - chaperone protein DnaK Mthe_0731 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 116754386 Common - UDP-glucose 6-dehydrogenase Mthe_1081 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 116753923 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding Mthe_0610 8 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 116754587 Common - DsrE family protein Mthe_1287 15 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 116753394 Common - gas vesicle protein GVPa Mthe_0070 22 None None None 116754619 Common - translation initiation factor IF-2 subunit gamma Mthe_1319 249 COG5257 GCD11, Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase) Translation, ribosomal structure and biogenesis 116754315 Common - putative phosphoserine phosphatase Mthe_1008 29 COG1340 COG1340, Uncharacterized archaeal coiled-coil protein Function unknown 116754589 Common - arsenical-resistance protein Mthe_1289 133 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 116753911 Nonpathogen - putative transcriptional regulator, AsnC family Mthe_0598 12 COG1522 Lrp, Transcriptional regulators Transcription 116754672 Common - RNA methyltransferase, TrmH family, group 1 Mthe_1375 155 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 116753384 Common - gas vesicle synthesis protein GvpA Mthe_0060 22 None None None 116754982 Nonpathogen - protein of unknown function UPF0153 Mthe_1694 3 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 116753975 Nonpathogen - hypothetical protein Mthe_0663 8 None None None 116753557 Nonpathogen - Deoxyribodipyrimidine photolyase-like Mthe_0237 12 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 116754433 Nonpathogen - hypothetical protein Mthe_1128 1 None None None 116754157 Nonpathogen - amino acid-binding ACT domain protein Mthe_0846 18 COG2061 COG2061, ACT-domain-containing protein, predicted allosteric regulator of homoserine dehydrogenase Amino acid transport and metabolism 116754180 Nonpathogen - hypothetical protein Mthe_0870 1 None None None 116753875 Common - Radical SAM domain protein Mthe_0562 45 COG0731 COG0731, Fe-S oxidoreductases Energy production and conversion 116754214 Common - YHS domain protein Mthe_0904 40 COG3350 COG3350, Uncharacterized conserved protein Function unknown 116754767 Common - ATPase, P-type (transporting), HAD superfamily, subfamily IC Mthe_1471 232 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 116753832 Common - transposase, IS4 family protein Mthe_0519 26 None None None 116753716 Common - hypothetical protein Mthe_0401 6 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 116754425 Nonpathogen - diphthine synthase Mthe_1120 34 COG1798 DPH5, Diphthamide biosynthesis methyltransferase Translation, ribosomal structure and biogenesis 116754630 Nonpathogen - Protein of unknown function DUF372 Mthe_1332 20 COG2098 COG2098, Uncharacterized protein conserved in archaea Function unknown 116753347 Common - glutamyl-tRNA(Gln) amidotransferase subunit E Mthe_0022 196 COG2511 GatE, Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain) Translation, ribosomal structure and biogenesis 116753356 Nonpathogen - ribosomal protein L7Ae/L30e/S12e/Gadd45 Mthe_0031 26 COG1911 RPL30, Ribosomal protein L30E Translation, ribosomal structure and biogenesis 116753720 Common - phosphate binding protein Mthe_0405 159 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 116754794 Common - protein of unknown function DUF92, transmembrane Mthe_1500 47 COG1836 COG1836, Predicted membrane protein Function unknown 116754886 Common - periplasmic binding protein Mthe_1596 93 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 116754906 Nonpathogen - hypothetical protein Mthe_1617 1 None None None 116753661 Nonpathogen - hypothetical protein Mthe_0345 2 None None None 116754222 Common - 4Fe-4S ferredoxin, iron-sulfur binding Mthe_0912 31 None None None 116754912 Common - Sulfopyruvate decarboxylase Mthe_1623 34 COG4032 COG4032, Predicted thiamine-pyrophosphate-binding protein General function prediction only 116754505 Common - ABC transporter related Mthe_1202 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 116754156 Common - Homoserine dehydrogenase Mthe_0845 218 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 116754878 Nonpathogen - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Mthe_1586 6 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 116754730 Nonpathogen - GHMP kinase Mthe_1433 32 COG1829 COG1829, Predicted archaeal kinase (sugar kinase superfamily) General function prediction only 116753421 Nonpathogen - hypothetical protein Mthe_0097 1 None None None 116754134 Common - GTP-binding protein Mthe_0823 64 COG0218 COG0218, Predicted GTPase General function prediction only 116753374 Common - delta-aminolevulinic acid dehydratase Mthe_0050 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 116753884 Nonpathogen - Methyl-coenzyme M reductase, protein D Mthe_0571 14 COG4055 McrD, Methyl coenzyme M reductase, subunit D Coenzyme metabolism 116754191 Nonpathogen - CDP-alcohol phosphatidyltransferase Mthe_0881 17 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 116754592 Nonpathogen - hypothetical protein Mthe_1292 9 None None None 116753668 Nonpathogen - hypothetical protein Mthe_0353 1 None None None 116754347 Common - transport system permease protein Mthe_1041 192 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 116754934 Common - thiamine pyrophosphate enzyme domain protein TPP-binding Mthe_1645 111 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 116754599 Common - hydrolase, TatD family Mthe_1299 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 116754530 Nonpathogen - hypothetical protein Mthe_1229 1 None None None 116755005 Common rpl24p 50S ribosomal protein L24P Mthe_1717 35 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 116754447 Common - ribosomal RNA methyltransferase RrmJ/FtsJ Mthe_1143 147 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 116754238 Common - protein of unknown function DUF151 Mthe_0928 79 COG1259 COG1259, Uncharacterized conserved protein Function unknown 116754597 Common - hypothetical protein Mthe_1297 26 COG2122 COG2122, Uncharacterized conserved protein Function unknown 116754496 Nonpathogen - hypothetical protein Mthe_1192 1 None None None 116754116 Common - heat shock protein Hsp20 Mthe_0805 41 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 116754625 Nonpathogen - Ribosomal protein S27a Mthe_1325 25 COG1998 RPS31, Ribosomal protein S27AE Translation, ribosomal structure and biogenesis 116754442 Nonpathogen - hypothetical protein Mthe_1137 10 COG4883 COG4883, Uncharacterized protein conserved in archaea Function unknown 116753782 Nonpathogen - hypothetical protein Mthe_0469 4 None None None 116754074 Common - AIR synthase related protein domain protein Mthe_0762 139 COG2144 COG2144, Selenophosphate synthetase-related proteins General function prediction only 116754466 Nonpathogen - hypothetical protein Mthe_1162 1 None None None 116754544 Nonpathogen - hypothetical protein Mthe_1243 8 COG4079 COG4079, Uncharacterized protein conserved in archaea Function unknown 116754228 Common - protein of unknown function DUF214 Mthe_0918 224 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 116755002 Nonpathogen - ribosomal protein S14 Mthe_1714 33 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 116754893 Nonpathogen cdc6 cell division control protein 6 Mthe_1604 31 COG1474 CDC6, Cdc6-related protein, AAA superfamily ATPase DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones 116754071 Common - hypothetical protein Mthe_0759 6 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 116754941 Common - protein of unknown function DUF224, cysteine-rich region domain protein Mthe_1652 143 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 116753816 Nonpathogen - putative transcriptional regulator, AsnC family Mthe_0503 18 COG1522 Lrp, Transcriptional regulators Transcription 116755017 Nonpathogen - Protein of unknown function DUF171 Mthe_1729 22 COG2106 COG2106, Uncharacterized conserved protein Function unknown 116753857 Common - UBA/THIF-type NAD/FAD binding protein Mthe_0544 223 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 116753597 Common - protein of unknown function DUF45 Mthe_0278 121 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 116754356 Common - NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Mthe_1050 162 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 116753800 Common - Methyltransferase type 11 Mthe_0487 40 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116754577 Common - tryptophan synthase subunit beta Mthe_1277 224 COG1350 COG1350, Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) General function prediction only 116754907 Nonpathogen rps13p 30S ribosomal protein S13P Mthe_1618 37 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 116754761 Common - Cl- channel, voltage-gated family protein Mthe_1465 209 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 116754623 Nonpathogen - Protein of unknown function DUF359 Mthe_1323 27 COG1909 COG1909, Uncharacterized protein conserved in archaea Function unknown 116754519 Common - adenylosuccinate lyase Mthe_1218 237 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 116753578 Common - MCM family protein Mthe_0259 38 COG1241 MCM2, Predicted ATPase involved in replication control, Cdc46/Mcm family DNA replication, recombination, and repair 116753414 Nonpathogen - hypothetical protein Mthe_0090 32 COG1439 COG1439, Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module General function prediction only 116753589 Nonpathogen - hypothetical protein Mthe_0270 6 COG0170 SEC59, Dolichol kinase Lipid metabolism 116753948 Common - CRISPR-associated protein Cas2 Mthe_0636 19 COG1343 COG1343, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 116754370 Common - glycosyl transferase, group 1 Mthe_1064 185 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116754444 Common - MIP family channel proteins Mthe_1139 122 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 116754557 Common pyrB aspartate carbamoyltransferase catalytic subunit Mthe_1256 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 116754607 Common ribH riboflavin synthase subunit beta Mthe_1307 210 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 116754694 Common - DNA polymerase Pol2 Mthe_1397 65 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 116754169 Common - binding-protein-dependent transport systems inner membrane component Mthe_0859 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 116754512 Common - putative transcriptional regulator Mthe_1210 73 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 116754804 Common - periplasmic copper-binding Mthe_1510 27 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 116754106 Nonpathogen - hypothetical protein Mthe_0795 1 None None None 116754163 Common - heat shock protein HtpX Mthe_0852 195 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 116754032 Nonpathogen - protein of unknown function DUF75 Mthe_0720 33 COG1938 COG1938, Archaeal enzymes of ATP-grasp superfamily General function prediction only 116754976 Nonpathogen - hypothetical protein Mthe_1688 1 None None None 116753785 Common - Farnesyltranstransferase Mthe_0472 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 116754264 Common - glucose-1-phosphate thymidyltransferase Mthe_0954 238 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 116754825 Common - integral membrane sensor signal transduction histidine kinase Mthe_1531 222 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 116754402 Common - Amidohydrolase 3 Mthe_1097 32 COG1229 FwdA, Formylmethanofuran dehydrogenase subunit A Energy production and conversion 116753959 Common - CRISPR-associated RAMP protein, Cmr4 family Mthe_0647 30 COG1336 COG1336, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 116754287 Common - CoB--CoM heterodisulfide reductase Mthe_0980 146 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 116754438 Common - thioredoxin Mthe_1133 236 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 116754890 Common - transposase Mthe_1600 23 COG5421 COG5421, Transposase DNA replication, recombination, and repair 116753774 Nonpathogen - DNA polymerase, beta domain protein region Mthe_0461 16 COG1665 COG1665, Uncharacterized protein conserved in archaea Function unknown 116754298 Common - amidohydrolase Mthe_0991 177 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 116754602 Common - translation initiation factor IF-2 Mthe_1302 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 116754765 Common - cytidine deaminase Mthe_1469 131 COG1478 COG1478, Uncharacterized conserved protein Function unknown 116753807 Nonpathogen - hypothetical protein Mthe_0494 14 COG4052 COG4052, Uncharacterized protein related to methyl coenzyme M reductase subunit C General function prediction only 116753907 Common - ATPases involved in chromosome partitioning-like Mthe_0594 230 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 116753822 Nonpathogen - hypothetical protein Mthe_0509 8 COG5643 COG5643, Protein containing a metal-binding domain shared with formylmethanofuran dehydrogenase subunit E General function prediction only 116754844 Common - glycosyl transferase, group 1 Mthe_1551 202 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116754601 Common - Rhomboid family protein Mthe_1301 149 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 116754710 Common - acetate--CoA ligase Mthe_1413 216 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 116753670 Common - protein of unknown function DUF198 Mthe_0355 65 COG1469 COG1469, Uncharacterized conserved protein Function unknown 116754651 Nonpathogen - shikimate kinase Mthe_1354 27 COG1685 COG1685, Archaeal shikimate kinase Amino acid transport and metabolism / Coenzyme metabolism 116754194 Common - SPP-like hydrolase Mthe_0884 114 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 116753649 Nonpathogen - Ribosomal protein L24E Mthe_0333 32 COG2075 RPL24A, Ribosomal protein L24E Translation, ribosomal structure and biogenesis 116753484 Common - ribonuclease H Mthe_0162 35 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 116753527 Common - protein of unknown function DUF521 Mthe_0207 39 COG1679 COG1679, Uncharacterized conserved protein Function unknown 116753354 Common - DNA-directed RNA polymerase subunit alpha Mthe_0029 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 116754791 Common - Creatininase Mthe_1497 85 COG1402 COG1402, Uncharacterized protein, putative amidase General function prediction only 116754658 Common - exosome complex RNA-binding protein Rrp42 Mthe_1361 61 COG2123 COG2123, RNase PH-related exoribonuclease Translation, ribosomal structure and biogenesis 116753471 Nonpathogen - S-layer-related duplication domain Mthe_0149 8 COG1749 FlgE, Flagellar hook protein FlgE Cell motility and secretion 116754110 Common - HAD-superfamily hydrolase, subfamily IIB Mthe_0799 99 COG0380 OtsA, Trehalose-6-phosphate synthase Carbohydrate transport and metabolism 116754786 Nonpathogen - protein of unknown function DUF112, transmembrane Mthe_1492 28 COG1784 COG1784, Predicted membrane protein Function unknown 116754373 Nonpathogen - Methyltransferase type 11 Mthe_1067 4 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116753868 Nonpathogen - hypothetical protein Mthe_0555 1 None None None 116753651 Nonpathogen - protein of unknown function DUF99 Mthe_0335 28 COG1628 COG1628, Uncharacterized conserved protein Function unknown 116754965 Common - glycosyl transferase, group 1 Mthe_1677 14 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116753658 Common - periplasmic binding protein Mthe_0342 139 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 116754852 Common - CRISPR-associated protein Cas2 Mthe_1560 17 COG1343 COG1343, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 116754142 Nonpathogen - Pre-mRNA processing ribonucleoprotein, binding region Mthe_0831 34 COG1498 SIK1, Protein implicated in ribosomal biogenesis, Nop56p homolog Translation, ribosomal structure and biogenesis 116754299 Nonpathogen - THUMP domain protein Mthe_0992 33 COG1258 COG1258, Predicted pseudouridylate synthase Translation, ribosomal structure and biogenesis 116753792 Nonpathogen - RNA polymerase Rpb6 Mthe_0479 29 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 116754361 Common - NADH dehydrogenase subunit J Mthe_1055 155 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 116754704 Common - AIR synthase related protein Mthe_1407 111 COG1973 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 116753606 Common - acetyl-CoA decarbonylase/synthase complex subunit gamma Mthe_0287 21 COG1456 CdhE, CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) Energy production and conversion 116754149 Nonpathogen - Protein of unknown function DUF1610 Mthe_0838 26 COG2888 COG2888, Predicted Zn-ribbon RNA-binding protein with a function in translation Translation, ribosomal structure and biogenesis 116754449 Common - UbiA prenyltransferase Mthe_1145 14 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 116753434 Common - acetolactate synthase 3 catalytic subunit Mthe_0110 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 116754216 Nonpathogen - hypothetical protein Mthe_0906 6 COG3462 COG3462, Predicted membrane protein Function unknown 116754021 Nonpathogen - hypothetical protein Mthe_0709 5 None None None 116753532 Common - Glutamate synthase (NADPH) Mthe_0212 208 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 116754390 Common - Bacitracin resistance protein BacA Mthe_1085 83 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 116753989 Nonpathogen - S-layer-related duplication domain Mthe_0677 3 COG5373 COG5373, Predicted membrane protein Function unknown 116754368 Common - NAD-dependent epimerase/dehydratase Mthe_1062 231 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116754252 Nonpathogen - nucleic acid binding, OB-fold, tRNA/helicase-type Mthe_0942 4 None None None 116754680 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit C Mthe_1383 14 COG4061 MtrC, Tetrahydromethanopterin S-methyltransferase, subunit C Coenzyme metabolism 116753401 Common - AAA family ATPase, CDC48 subfamily Mthe_0077 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 116754735 Common - LPPG Mthe_1438 41 COG0391 COG0391, Uncharacterized conserved protein Function unknown 116754174 Nonpathogen - protein of unknown function DUF343 Mthe_0864 12 COG2835 COG2835, Uncharacterized conserved protein Function unknown 116753450 Common - protein of unknown function DUF165 Mthe_0128 43 COG1738 COG1738, Uncharacterized conserved protein Function unknown 116754333 Nonpathogen - Transcription factor TFIIS Mthe_1026 33 COG1594 RPB9, DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS Transcription 116753526 Common - nicotinamide-nucleotide adenylyltransferase Mthe_0206 42 COG1056 NadR, Nicotinamide mononucleotide adenylyltransferase Coenzyme metabolism 116753893 Common - cobalt transport protein CbiM Mthe_0580 84 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 116753994 Common - cobalamin synthesis protein, P47K Mthe_0682 49 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 116754728 Common - deoxyribonuclease/rho motif-related TRAM Mthe_1431 26 COG3269 COG3269, Predicted RNA-binding protein, contains TRAM domain General function prediction only 116754503 Common - putative deoxyhypusine synthase Mthe_1200 63 COG1899 DYS1, Deoxyhypusine synthase Posttranslational modification, protein turnover, chaperones 116753642 Common - molybdopterin-guanine dinucleotide biosynthesis protein B Mthe_0326 53 COG1763 MobB, Molybdopterin-guanine dinucleotide biosynthesis protein Coenzyme metabolism 116753461 Common - nitrogen-fixing NifU domain protein Mthe_0139 94 COG0694 COG0694, Thioredoxin-like proteins and domains Posttranslational modification, protein turnover, chaperones 116754030 Nonpathogen - hypothetical protein Mthe_0718 1 None None None 116754862 Nonpathogen - conserved hypothetical ATP-binding protein Mthe_1570 19 COG2117 COG2117, Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 116753768 Common - bifunctional hexulose-6-phosphate synthase/ribonuclease regulator Mthe_0455 131 COG0269 SgbH, 3-hexulose-6-phosphate synthase and related proteins Carbohydrate transport and metabolism 116753980 Nonpathogen - hypothetical protein Mthe_0668 1 None None None 116754968 Common - glucosamine--fructose-6-phosphate aminotransferase, isomerizing Mthe_1680 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 116753513 Common - tryptophan synthase, alpha subunit Mthe_0192 219 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 116754366 Common - proton-translocating NADH-quinone oxidoreductase, chain N Mthe_1060 210 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 116753639 Common - periplasmic copper-binding Mthe_0322 28 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 116753890 Common - cobalt ABC transporter, ATPase subunit Mthe_0577 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 116754138 Nonpathogen - Ribosomal protein S17E-like Mthe_0827 31 COG1383 RPS17A, Ribosomal protein S17E Translation, ribosomal structure and biogenesis 116754379 Common - glycosyl transferase, group 1 Mthe_1073 200 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116754921 Common - GTP cyclohydrolase II Mthe_1632 232 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 116753599 Common - NAD-dependent epimerase/dehydratase Mthe_0280 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116754745 Nonpathogen - putative transcriptional regulator Mthe_1449 4 COG2345 COG2345, Predicted transcriptional regulator Transcription 116754532 Common - protein of unknown function DUF169 Mthe_1231 24 COG2043 COG2043, Uncharacterized protein conserved in archaea Function unknown 116754775 Common - phosphate binding protein Mthe_1480 162 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 116754661 Nonpathogen - Shwachman-Bodian-Diamond syndrome proteins Mthe_1364 34 COG1500 COG1500, Predicted exosome subunit Translation, ribosomal structure and biogenesis 116754235 Nonpathogen - hypothetical protein Mthe_0925 18 COG1885 COG1885, Uncharacterized protein conserved in archaea Function unknown 116753754 Common - Cobaltochelatase Mthe_0441 89 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 116753631 Common - beta-lactamase domain protein Mthe_0314 223 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 116754306 Nonpathogen - hypothetical protein Mthe_0999 1 None None None 116753495 Common - coenzyme F420 hydrogenase/dehydrogenase beta subunit domain protein Mthe_0174 39 COG1035 FrhB, Coenzyme F420-reducing hydrogenase, beta subunit Energy production and conversion 116753845 Common - fructose-bisphosphate aldolase Mthe_0532 86 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 116753753 Nonpathogen - hypothetical protein Mthe_0440 9 None None None 116754538 Nonpathogen rpl40e 50S ribosomal protein L40e Mthe_1237 25 COG1552 RPL40A, Ribosomal protein L40E Translation, ribosomal structure and biogenesis 116753488 Common - phosphoglyceromutase Mthe_0167 125 COG0696 GpmI, Phosphoglyceromutase Carbohydrate transport and metabolism 116753728 Nonpathogen - protein of unknown function DUF75 Mthe_0414 24 COG2047 COG2047, Uncharacterized protein (ATP-grasp superfamily) General function prediction only 116753528 Common - protein of unknown function DUF126 Mthe_0208 36 COG1786 COG1786, Uncharacterized conserved protein Function unknown 116753963 Nonpathogen - CRISPR-associated protein, TM1812 family Mthe_0651 16 None None None 116753936 Common aspC aspartyl-tRNA synthetase Mthe_0623 249 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 116754865 Common - CoB--CoM heterodisulfide reductase Mthe_1573 51 COG2048 HdrB, Heterodisulfide reductase, subunit B Energy production and conversion 116754000 Common - beta-lactamase domain protein Mthe_0688 200 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 116753406 Common - beta-lactamase domain protein Mthe_0082 172 COG1782 COG1782, Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain General function prediction only 116753432 Common - Radical SAM domain protein Mthe_0108 48 COG0731 COG0731, Fe-S oxidoreductases Energy production and conversion 116754365 Common - proton-translocating NADH-quinone oxidoreductase, chain M Mthe_1059 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 116754709 Common - protein of unknown function DUF163 Mthe_1412 167 COG1576 COG1576, Uncharacterized conserved protein Function unknown 116753430 Nonpathogen - hypothetical protein Mthe_0106 34 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 116754572 Common surE stationary phase survival protein SurE Mthe_1272 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 116753630 Common - acetylornithine and succinylornithine aminotransferases Mthe_0313 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 116753842 Common - ABC transporter related Mthe_0529 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116753468 Common - precorrin-4 C11-methyltransferase Mthe_0146 203 COG2875 CobM, Precorrin-4 methylase Coenzyme metabolism 116754230 Common - SNO glutamine amidotransferase Mthe_0920 88 COG0311 PDX2, Predicted glutamine amidotransferase involved in pyridoxine biosynthesis Coenzyme metabolism 116754746 Common - L-fuculose phosphate aldolase Mthe_1450 136 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 116753376 Nonpathogen - hypothetical protein Mthe_0052 4 None None None 116753451 Common - queuine tRNA-ribosyltransferase Mthe_0129 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 116753794 Common rps9p 30S ribosomal protein S9P Mthe_0481 70 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 116753423 Common - phosphoribosylformylglycinamidine synthase II Mthe_0099 234 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 116754395 Nonpathogen - hypothetical protein Mthe_1090 2 None None None 116754064 Common - hypothetical protein Mthe_0752 28 COG3875 COG3875, Uncharacterized conserved protein Function unknown 116754255 Nonpathogen - lipopolysaccharide biosynthesis Mthe_0945 2 COG3765 WzzB, Chain length determinant protein Cell envelope biogenesis, outer membrane 116753638 Nonpathogen - hypothetical protein Mthe_0321 1 None None None 116753900 Common - ABC transporter related Mthe_0587 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 116753973 Nonpathogen - fibrillarin Mthe_0661 34 COG1889 NOP1, Fibrillarin-like rRNA methylase Translation, ribosomal structure and biogenesis 116753996 Common - Carbonate dehydratase Mthe_0684 165 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 116754969 Common - periplasmic solute binding protein Mthe_1681 53 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 116753437 Nonpathogen - hypothetical protein Mthe_0115 5 None None None 116753921 Common - nuclease (SNase domain protein) Mthe_0608 23 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 116754427 Nonpathogen - Protein of unknown function UPF0146 Mthe_1122 15 COG1255 COG1255, Uncharacterized protein conserved in archaea Function unknown 116753541 Common cofG FO synthase subunit 1 Mthe_0221 46 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 116754236 Common radB DNA repair and recombination protein RadB Mthe_0926 224 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 116754550 Common - carbohydrate kinase, FGGY Mthe_1249 176 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 116753496 Common - translation-associated GTPase Mthe_0175 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 116754450 Common - glucose-6-phosphate isomerase Mthe_1146 18 COG2140 COG2140, Thermophilic glucose-6-phosphate isomerase and related metalloenzymes Carbohydrate transport and metabolism / General function prediction only 116753598 Common - putative methylase Mthe_0279 88 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 116753680 Common - translation initiation factor IF-2B subunit alpha Mthe_0365 132 COG0182 COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 116754856 Common - signal recognition particle-docking protein FtsY Mthe_1564 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 116753644 Common - cation diffusion facilitator family transporter Mthe_0328 207 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 116753519 Common - pentapeptide repeat protein Mthe_0198 117 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 116754114 Common - DJ-1 family protein Mthe_0803 179 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 116753555 Nonpathogen - hypothetical protein Mthe_0235 1 None None None 116753986 Common - 2'-5' RNA ligase Mthe_0674 103 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 116754698 Common - uncharacterized domain protein Mthe_1401 54 COG1944 COG1944, Uncharacterized conserved protein Function unknown 116754981 Common - glutamate--cysteine ligase, GCS2 Mthe_1693 13 COG2170 COG2170, Uncharacterized conserved protein Function unknown 116754823 Common - putative small multi-drug export Mthe_1529 19 COG2426 COG2426, Predicted membrane protein Function unknown 116754405 Nonpathogen - hypothetical protein Mthe_1100 1 None None None 116754774 Common - phage SPO1 DNA polymerase-related protein Mthe_1479 154 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 116754895 Common - Threonyl/alanyl tRNA synthetase, SAD Mthe_1606 248 COG2872 COG2872, Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain General function prediction only 116753703 Nonpathogen - hypothetical protein Mthe_0388 10 COG4738 COG4738, Predicted transcriptional regulator Transcription 116754297 Common - homoaconitate hydratase family protein Mthe_0990 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 116753525 Common - methylenetetrahydromethanopterin reductase Mthe_0205 45 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 116754604 Common - Adenylosuccinate synthase Mthe_1304 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 116753442 Nonpathogen rps15p 30S ribosomal protein S15P Mthe_0120 34 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 116754686 Nonpathogen - transcriptional regulator, XRE family Mthe_1389 29 COG1709 COG1709, Predicted transcriptional regulator Transcription 116754653 Nonpathogen - hypothetical protein Mthe_1356 3 None None None 116753687 Common - protein of unknown function UPF0118 Mthe_0372 134 COG0628 PerM, Predicted permease General function prediction only 116754411 Nonpathogen - cytochrome c biogenesis protein, transmembrane region Mthe_1106 7 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 116754956 Nonpathogen - hypothetical protein Mthe_1668 3 None None None 116753573 Common - glycogen debranching enzyme, putative Mthe_0254 43 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 116753889 Nonpathogen - hypothetical protein Mthe_0576 1 None None None 116754510 Common - type I restriction-modification system restriction subunit Mthe_1207 16 None None None 116754371 Common - ABC-2 type transporter Mthe_1065 120 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116754475 Common - indolepyruvate oxidoreductase subunit B Mthe_1171 67 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 116753336 Common - CutA1 divalent ion tolerance protein Mthe_0011 119 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 116754991 Common - cytidylate kinase Mthe_1703 42 COG1102 Cmk, Cytidylate kinase Nucleotide transport and metabolism 116754838 Nonpathogen - hypothetical protein Mthe_1545 1 None None None 116753981 Nonpathogen - Protein of unknown function DUF128 Mthe_0669 16 COG1693 COG1693, Uncharacterized protein conserved in archaea Function unknown 116754268 Common - polysaccharide biosynthesis protein Mthe_0958 19 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 116753509 Nonpathogen - ribosome biogenesis protein Mthe_0188 18 COG1756 Mra1, Uncharacterized conserved protein Function unknown 116754094 Common - alkylhydroperoxidase like protein, AhpD family Mthe_0782 66 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 116754842 Common - glycosyl transferase, group 1 Mthe_1549 225 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116753870 Common - MRP/NBP35 family ATP-binding protein Mthe_0557 230 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 116753671 Nonpathogen - hypothetical protein Mthe_0356 1 None None None 116753416 Common - ABC transporter related Mthe_0092 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 116754262 Common - UDP-glucose 6-dehydrogenase Mthe_0952 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 116754286 Nonpathogen - hypothetical protein Mthe_0979 1 None None None 116753449 Nonpathogen - Protein of unknown function DUF373 Mthe_0127 29 COG2237 COG2237, Predicted membrane protein Function unknown 116754168 Common - binding-protein-dependent transport systems inner membrane component Mthe_0858 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 116754609 Common - exodeoxyribonuclease VII, large subunit Mthe_1309 204 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 116753400 Nonpathogen - PRC-barrel domain protein Mthe_0076 17 COG1873 COG1873, Uncharacterized conserved protein Function unknown 116753945 Nonpathogen - protein translocase SEC61 complex, gamma subunit Mthe_0632 2 COG2443 Sss1, Preprotein translocase subunit Sss1 Intracellular trafficking and secretion 116754909 Common rps11p 30S ribosomal protein S11P Mthe_1620 138 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 116753582 Common - GPR1/FUN34/yaaH family protein Mthe_0263 51 COG1584 COG1584, Predicted membrane protein Function unknown 116754578 Common - Na+/solute symporter Mthe_1278 153 COG4145 PanF, Na+/panthothenate symporter Coenzyme metabolism 116753500 Nonpathogen - hypothetical protein Mthe_0179 1 None None None 116753708 Nonpathogen - hypothetical protein Mthe_0393 3 None None None 116754376 Common - hypothetical protein Mthe_1070 3 None None None 116753491 Common - protein of unknown function RIO1 Mthe_0170 66 COG1718 RIO1, Serine/threonine protein kinase involved in cell cycle control Signal transduction mechanisms / Cell division and chromosome partitioning 116754805 Common - Phosphoribosylaminoimidazolecarboxamide formyltransferase Mthe_1511 218 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 116754523 Nonpathogen - hypothetical protein Mthe_1222 3 None None None 116754243 Common - histidyl-tRNA synthetase Mthe_0933 249 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116753863 Nonpathogen - Protein of unknown function DUF166 Mthe_0550 10 COG1810 COG1810, Uncharacterized protein conserved in archaea Function unknown 116753604 Common - aconitate hydratase Mthe_0285 223 COG1048 AcnA, Aconitase A Energy production and conversion 116754468 Nonpathogen - Oligosaccharyl transferase, STT3 subunit Mthe_1164 18 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 116754137 Common - dihydrodipicolinate synthase Mthe_0826 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 116754057 Common - diaminopimelate decarboxylase Mthe_0745 217 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 116753395 Nonpathogen - gas vesicle protein GVPa Mthe_0071 11 None None None 116753905 Common - putative transcriptional regulator Mthe_0592 150 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 116753692 Common - ABC transporter related Mthe_0377 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116754429 Common - uroporphyrin-III C-methyltransferase Mthe_1124 206 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 116754521 Nonpathogen - hypothetical protein Mthe_1220 14 COG3365 COG3365, Uncharacterized protein conserved in archaea Function unknown 116755019 Common - protein of unknown function DUF107 Mthe_1731 72 COG1030 NfeD, Membrane-bound serine protease (ClpP class) Posttranslational modification, protein turnover, chaperones 116753711 Common - TrkA-N domain protein Mthe_0396 147 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 116753771 Common - proteasome-activating nucleotidase Mthe_0458 249 COG1222 RPT1, ATP-dependent 26S proteasome regulatory subunit Posttranslational modification, protein turnover, chaperones 116754132 Common - elongation factor 1-alpha Mthe_0821 249 COG5256 TEF1, Translation elongation factor EF-1alpha (GTPase) Translation, ribosomal structure and biogenesis 116753829 Nonpathogen - hypothetical protein Mthe_0516 1 None None None 116754339 Common - ABC transporter related Mthe_1033 249 COG1124 DppF, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 116753844 Common - AAA family ATPase, CDC48 subfamily Mthe_0531 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 116754091 Common - DEAD/DEAH box helicase domain protein Mthe_0779 237 COG1201 Lhr, Lhr-like helicases General function prediction only 116755000 Common - ribosomal protein L6 Mthe_1712 236 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 116754200 Common - cell division protein FtsZ Mthe_0890 233 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 116754763 Common - NUDIX hydrolase Mthe_1467 176 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 116754939 Nonpathogen - Transcription factor TFIIE, alpha subunit Mthe_1650 32 COG1675 TFA1, Transcription initiation factor IIE, alpha subunit Transcription 116753425 Common - glycerophosphoryl diester phosphodiesterase Mthe_0101 170 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 116754559 Common - phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II Mthe_1258 240 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 116753818 Nonpathogen - hypothetical protein Mthe_0505 4 None None None 116754771 Nonpathogen - methyltransferase Mthe_1475 10 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 116754348 Common - periplasmic binding protein Mthe_1042 127 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 116754188 Common - Cobaltochelatase Mthe_0878 164 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 116753619 Common - putative signal transduction protein with CBS domains Mthe_0302 206 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 116753343 Common - Radical SAM domain protein Mthe_0018 52 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116753865 Common - hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta subunit Mthe_0552 126 COG1838 FumA, Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain Energy production and conversion 116753877 Common - Cobyrinic acid a,c-diamide synthase Mthe_0564 120 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 116754517 Common - carbon-monoxide dehydrogenase, catalytic subunit Mthe_1216 24 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 116753968 Common - methionine aminopeptidase Mthe_0656 234 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 116754892 Common - Cna B domain protein Mthe_1602 94 COG4932 COG4932, Predicted outer membrane protein Cell envelope biogenesis, outer membrane 116754643 Nonpathogen - hypothetical protein Mthe_1346 4 None None None 116754087 Common - ABC transporter related Mthe_0775 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 116753382 Common - gas vesicle protein GvpN Mthe_0058 69 COG0714 COG0714, MoxR-like ATPases General function prediction only 116754897 Common - V-type ATP synthase subunit B Mthe_1608 247 COG1156 NtpB, Archaeal/vacuolar-type H+-ATPase subunit B Energy production and conversion 116754900 Common - V-type ATP synthase subunit C Mthe_1611 30 COG1527 NtpC, Archaeal/vacuolar-type H+-ATPase subunit C Energy production and conversion 116754218 Nonpathogen - glutaredoxin Mthe_0908 13 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 116754158 Common - cell surface protein Mthe_0847 35 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 116754499 Common - acetate--CoA ligase Mthe_1196 216 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 116753676 Common - Xylose isomerase domain protein TIM barrel Mthe_0361 52 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116754776 Nonpathogen - hypothetical protein Mthe_1481 3 None None None 116754482 Common - Nitrogenase Mthe_1178 100 COG1348 NifH, Nitrogenase subunit NifH (ATPase) Inorganic ion transport and metabolism 116753880 Common - cation diffusion facilitator family transporter Mthe_0567 185 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 116754853 Nonpathogen - CRISPR locus-related DNA-binding protein Mthe_1561 6 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 116754502 Nonpathogen - hypothetical protein Mthe_1199 1 COG2425 COG2425, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 116753858 Common - proposed homoserine kinase Mthe_0545 57 COG3635 COG3635, Predicted phosphoglycerate mutase, AP superfamily Carbohydrate transport and metabolism 116754224 Common - ferredoxin--NADP(+) reductase subunit alpha Mthe_0914 86 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 116754420 Nonpathogen - hypothetical protein Mthe_1115 1 None None None 116754612 Common - fructose-bisphosphate aldolase Mthe_1312 85 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 116753611 Common - acetyl-CoA decarbonylase/synthase complex subunit alpha Mthe_0292 18 COG1152 CdhA, CO dehydrogenase/acetyl-CoA synthase alpha subunit Energy production and conversion 116753389 Common - PAS/PAC sensor signal transduction histidine kinase Mthe_0065 223 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 116754836 Common - Indole-3-glycerol-phosphate synthase Mthe_1543 219 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 116754161 Common - hypothetical protein Mthe_0850 10 None None None 116754678 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit A Mthe_1381 17 COG4063 MtrA, Tetrahydromethanopterin S-methyltransferase, subunit A Coenzyme metabolism 116753663 Common - hypothetical protein Mthe_0348 26 COG1891 COG1891, Uncharacterized protein conserved in archaea Function unknown 116754930 Common - protein of unknown function DUF201 Mthe_1641 20 COG1821 COG1821, Predicted ATP-utilizing enzyme (ATP-grasp superfamily) General function prediction only 116754023 Common - thioredoxin Mthe_0711 234 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 116753787 Common - isopentenyl-diphosphate delta-isomerase, type 2 Mthe_0474 80 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 116754058 Common - PBS lyase HEAT domain protein repeat-containing protein Mthe_0746 49 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 116753929 Nonpathogen - hypothetical protein Mthe_0616 1 None None None 116754815 Nonpathogen - hypothetical protein Mthe_1521 1 None None None 116753474 Nonpathogen - transcription factor Mthe_0152 34 COG2101 SPT15, TATA-box binding protein (TBP), component of TFIID and TFIIIB Transcription 116753738 Nonpathogen - hypothetical protein Mthe_0424 1 None None None 116754950 Nonpathogen - hypothetical protein Mthe_1662 1 None None None 116753566 Common - O-sialoglycoprotein endopeptidase Mthe_0247 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 116753820 Nonpathogen - protein of unknown function DUF123 Mthe_0507 36 COG1833 COG1833, Uncharacterized conserved protein Function unknown 116754324 Common - cobalamin 5'-phosphate synthase Mthe_1017 110 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 116753392 Common - RecA-superfamily ATPases, implicated in signal transduction Mthe_0068 43 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 116753571 Common - N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase Mthe_0252 27 COG3252 COG3252, Methenyltetrahydromethanopterin cyclohydrolase Coenzyme metabolism 116754308 Common - cobyrinic acid a,c-diamide synthase Mthe_1001 136 COG1797 CobB, Cobyrinic acid a,c-diamide synthase Coenzyme metabolism 116754416 Common - adenine phosphoribosyltransferase Mthe_1111 182 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 116754757 Common - major facilitator superfamily MFS_1 Mthe_1461 112 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116754478 Nonpathogen - hypothetical protein Mthe_1174 1 None None None 116754275 Common - glycosyl transferase, family 2 Mthe_0965 107 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 116755020 Common - acetylglutamate kinase Mthe_1732 219 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 116754028 Common - KaiC Mthe_0716 62 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 116754719 Common - ribosomal protein L11 Mthe_1422 236 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 116754845 Common - glycogen synthase Mthe_1552 10 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 116753978 Nonpathogen - hypothetical protein Mthe_0666 1 COG1470 COG1470, Predicted membrane protein Function unknown 116754044 Common - GrpE protein Mthe_0732 232 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 116754994 Nonpathogen - ribosomal protein L15 Mthe_1706 15 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 116753741 Nonpathogen - hypothetical protein Mthe_0427 1 None None None 116754233 Common - UspA domain protein Mthe_0923 83 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 116754069 Common - phosphoglycerate mutase 1 family Mthe_0757 145 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 116754928 Common - protein of unknown function DUF95, transmembrane Mthe_1639 26 COG1300 SpoIIM, Uncharacterized membrane protein Function unknown 116754431 Common - glutamate-1-semialdehyde aminotransferase Mthe_1126 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 116753587 Nonpathogen - hypothetical protein Mthe_0268 3 COG1710 COG1710, Uncharacterized protein conserved in archaea Function unknown 116753622 Common - putative signal-transduction protein with CBS domains Mthe_0305 161 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 116754887 Common - periplasmic binding protein Mthe_1597 137 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 116755001 Common - ribosomal protein S8 Mthe_1713 205 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 116754983 Common - RimK domain protein ATP-grasp Mthe_1695 74 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 116754692 Common - transposase, IS605 OrfB family Mthe_1395 75 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 116754638 Common - carbon-monoxide dehydrogenase, catalytic subunit Mthe_1341 50 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 116755021 Common - pyruvate carboxylase subunit B Mthe_1733 203 COG5016 COG5016, Pyruvate/oxaloacetate carboxyltransferase Energy production and conversion 116754048 Nonpathogen - protein of unknown function Met10 Mthe_0736 35 COG2520 COG2520, Predicted methyltransferase General function prediction only 116755018 Common - band 7 protein Mthe_1730 220 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 116753596 Nonpathogen - hypothetical protein Mthe_0277 2 None None None 116753516 Nonpathogen - hypothetical protein Mthe_0195 1 None None None 116753575 Common ubiA prenyltransferase Mthe_0256 14 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 116754381 Common - hypothetical protein Mthe_1075 14 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116754563 Common - translation initiation factor IF-2B subunit delta Mthe_1262 132 COG1184 GCD2, Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 116754013 Nonpathogen - hypothetical protein Mthe_0701 30 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 116754151 Common - NAD(+) kinase Mthe_0840 240 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 116754346 Common - dienelactone hydrolase Mthe_1040 33 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116754203 Nonpathogen - protein of unknown function DUF1232 Mthe_0893 7 COG3339 COG3339, Uncharacterized conserved protein Function unknown 116754493 Common - acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase Mthe_1189 23 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 116754918 Common - Bacitracin resistance protein BacA Mthe_1629 198 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 116753947 Common - glutamine synthetase, type I Mthe_0634 226 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 116753629 Common - histidinol-phosphate aminotransferase Mthe_0312 238 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 116754331 Common - pentapeptide repeat protein Mthe_1024 105 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 116754488 Common - transposase, IS4 family protein Mthe_1184 26 None None None 116753518 Common - von Willebrand factor, type A Mthe_0197 76 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 116754066 Nonpathogen - hypothetical protein Mthe_0754 1 None None None 116754738 Nonpathogen - hypothetical protein Mthe_1442 1 None None None 116753758 Nonpathogen - hypothetical protein Mthe_0445 1 None None None 116754528 Common - ABC-2 type transporter Mthe_1227 195 COG1511 COG1511, Predicted membrane protein Function unknown 116754457 Common - putative signal transduction protein with CBS domains Mthe_1153 35 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 116754748 Nonpathogen cdc6 cell division control protein 6 Mthe_1452 31 COG1474 CDC6, Cdc6-related protein, AAA superfamily ATPase DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones 116753505 Nonpathogen purP 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase Mthe_0184 20 COG1759 COG1759, ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases) General function prediction only 116753727 Common - peptidase U62, modulator of DNA gyrase Mthe_0413 162 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 116753872 Common - Dinitrogenase iron-molybdenum cofactor biosynthesis Mthe_0559 40 COG1433 COG1433, Uncharacterized conserved protein Function unknown 116753998 Common - 1-phosphofructokinase Mthe_0686 123 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 116753349 Common leuD 3-isopropylmalate dehydratase small subunit Mthe_0024 210 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 116754945 Common - phosphoribosylglycinamide formyltransferase Mthe_1657 222 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 116754552 Common - protein of unknown function DUF296 Mthe_1251 32 COG1661 COG1661, Predicted DNA-binding protein with PD1-like DNA-binding motif General function prediction only 116754669 Common - Radical SAM domain protein Mthe_1372 51 COG1313 PflX, Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins General function prediction only 116754388 Nonpathogen - Protein of unknown function DUF1616 Mthe_1083 8 COG4743 COG4743, Predicted membrane protein Function unknown 116754854 Nonpathogen - CRISPR-associated protein, TM1814 Mthe_1562 6 COG5551 COG5551, Uncharacterized conserved protein Function unknown 116753781 Common - Na+/solute symporter Mthe_0468 152 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 116754125 Common - hypothetical protein Mthe_0814 3 COG2510 COG2510, Predicted membrane protein Function unknown 116753371 Common - Carbohydrate-binding and sugar hydrolysis Mthe_0046 52 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 116754452 Common moaA molybdenum cofactor biosynthesis protein A Mthe_1148 208 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 116753796 Nonpathogen - 50S ribosomal protein L18e Mthe_0483 34 COG1727 RPL18A, Ribosomal protein L18E Translation, ribosomal structure and biogenesis 116753636 Common - N-glycosylase/DNA lyase Mthe_0319 15 COG1059 COG1059, Thermostable 8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 116754446 Common - UbiA prenyltransferase Mthe_1142 120 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 116754213 Common - dihydrolipoamide dehydrogenase Mthe_0903 244 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 116753849 Common - ABC transporter related Mthe_0536 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 116754802 Common - ferredoxin-dependent glutamate synthase Mthe_1508 43 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 116754574 Common - Rhodanese domain protein Mthe_1274 122 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 116753458 Common - NAD-dependent epimerase/dehydratase Mthe_0136 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116754176 Nonpathogen - hypothetical protein Mthe_0866 16 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 116754721 Nonpathogen - hypothetical protein Mthe_1424 1 None None None 116754849 Common - DEAD/DEAH box helicase domain protein Mthe_1557 19 COG1205 COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster General function prediction only 116754294 Common - metalloenzyme domain protein Mthe_0987 10 COG0696 GpmI, Phosphoglyceromutase Carbohydrate transport and metabolism 116754610 Common - hypothetical protein Mthe_1310 13 None None None 116753898 Common - protein of unknown function DUF214 Mthe_0585 187 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 116754963 Common - glycosyl transferase, group 1 Mthe_1675 209 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116753466 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Mthe_0144 160 COG1010 CobJ, Precorrin-3B methylase Coenzyme metabolism 116753766 Common - Rhodanese domain protein Mthe_0453 120 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 116754882 Nonpathogen - transposase Mthe_1590 3 None None None 116753853 Common - 3-dehydroquinate dehydratase, type I Mthe_0540 56 COG0710 AroD, 3-dehydroquinate dehydratase Amino acid transport and metabolism 116753751 Common - 6-pyruvoyl tetrahydropterin synthase and hypothetical protein Mthe_0437 140 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 116754640 Common - GCN5-related N-acetyltransferase Mthe_1343 148 COG0456 RimI, Acetyltransferases General function prediction only 116754536 Common - UDP-N-acetylglucosamine 2-epimerase Mthe_1235 150 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 116753378 Nonpathogen - hypothetical protein Mthe_0054 1 None None None 116754363 Common - NADH-ubiquinone oxidoreductase, chain 4L Mthe_1057 120 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 116753403 Nonpathogen - 30S ribosomal protein S3Ae Mthe_0079 34 COG1890 RPS1A, Ribosomal protein S3AE Translation, ribosomal structure and biogenesis 116754249 Common - Tetratricopeptide TPR_2 repeat protein Mthe_0939 72 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116754301 Nonpathogen - RNA polymerase Rpb4 Mthe_0994 20 COG1460 COG1460, Uncharacterized protein conserved in archaea Function unknown 116754295 Common - bifunctional formaldehyde-activating enzyme/3-hexulose-6-phosphate synthase Mthe_0988 52 COG1795 COG1795, Uncharacterized conserved protein Function unknown 116754649 Common - putative ATP binding protein Mthe_1352 50 COG2102 COG2102, Predicted ATPases of PP-loop superfamily General function prediction only 116753840 Common - glycosyl transferase, family 2 Mthe_0527 172 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116753760 Common - transport system permease protein Mthe_0447 190 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 116753891 Common - cobalt ABC transporter, inner membrane subunit CbiQ Mthe_0578 72 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 116754051 Nonpathogen - hypothetical protein Mthe_0739 1 None None None 116753478 Common - 2-ketoisovalerate ferredoxin reductase Mthe_0156 111 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 116753332 Common - putative ATPase RIL Mthe_0007 249 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 116753486 Nonpathogen - protein of unknown function UPF0153 Mthe_0165 11 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 116753903 Nonpathogen nac nascent polypeptide-associated complex protein Mthe_0590 31 COG1308 EGD2, Transcription factor homologous to NACalpha-BTF3 Transcription 116753418 Common - Carboxymuconolactone decarboxylase Mthe_0094 55 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 116753538 Common - ABC transporter related Mthe_0218 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 116753507 Common - phosphodiesterase, MJ0936 family Mthe_0186 69 COG0622 COG0622, Predicted phosphoesterase General function prediction only 116753957 Common - CRISPR-associated RAMP protein, Cmr6 family Mthe_0645 28 COG1604 COG1604, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 116753435 Common - acetolactate synthase, small subunit Mthe_0111 193 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 116753493 Nonpathogen - peptidase M50 Mthe_0172 30 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 116753943 Common - multi-sensor signal transduction histidine kinase Mthe_0630 222 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 116753580 Common - amino acid-binding ACT domain protein Mthe_0261 38 COG4747 COG4747, ACT domain-containing protein General function prediction only 116754096 Common - extracellular solute-binding protein, family 5 Mthe_0785 205 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 116753657 Nonpathogen - metallophosphoesterase Mthe_0341 2 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 116754266 Common - dTDP-glucose 4,6-dehydratase Mthe_0956 233 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 116753805 Common - argininosuccinate lyase Mthe_0492 232 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 116754251 Common - beta-lactamase domain protein Mthe_0941 31 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 116754662 Nonpathogen - proteasome subunit alpha Mthe_1365 34 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 116754788 Nonpathogen - protein of unknown function DUF369 Mthe_1494 11 COG2164 COG2164, Uncharacterized conserved protein Function unknown 116754322 Common - histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase HisB Mthe_1015 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 116754337 Nonpathogen - hypothetical protein Mthe_1030 3 None None None 116754489 Common - periplasmic binding protein Mthe_1185 127 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 116754199 Nonpathogen - transcriptional regulator, TrmB Mthe_0889 10 COG4738 COG4738, Predicted transcriptional regulator Transcription 116754007 Nonpathogen - transposase Mthe_0695 2 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 116753673 Nonpathogen - hypothetical protein Mthe_0358 3 None None None 116753990 Common - Mn2+-dependent serine/threonine protein kinase Mthe_0678 37 COG3642 COG3642, Mn2+-dependent serine/threonine protein kinase Signal transduction mechanisms 116754101 Common - phosphopantetheine adenylyltransferase Mthe_0790 29 COG1019 COG1019, Predicted nucleotidyltransferase General function prediction only 116753713 Common truD tRNA pseudouridine synthase D Mthe_0398 92 COG0585 COG0585, Uncharacterized conserved protein Function unknown 116754492 Common - transposase Mthe_1188 23 COG5421 COG5421, Transposase DNA replication, recombination, and repair 116754185 Common - protein of unknown function DUF549 Mthe_0875 19 COG4021 COG4021, Uncharacterized conserved protein Function unknown 116754925 Common - Pyridoxal-dependent decarboxylase Mthe_1636 142 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 116753954 Nonpathogen - hypothetical protein Mthe_0642 5 None None None 116754473 Common - exodeoxyribonuclease VII, small subunit Mthe_1169 138 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 116754828 Common - protein of unknown function DUF814 Mthe_1534 65 COG1293 COG1293, Predicted RNA-binding protein homologous to eukaryotic snRNP Transcription 116754867 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Mthe_1575 129 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 116754655 Nonpathogen - hypothetical protein Mthe_1358 9 COG2892 COG2892, Uncharacterized protein conserved in archaea Function unknown 116754821 Nonpathogen - TOPRIM domain protein Mthe_1527 13 COG1658 COG1658, Small primase-like proteins (Toprim domain) DNA replication, recombination, and repair 116754407 Common - periplasmic solute binding protein Mthe_1102 181 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 116754210 Common - Aldehyde ferredoxin oxidoreductase Mthe_0900 57 COG2414 COG2414, Aldehyde:ferredoxin oxidoreductase Energy production and conversion 116753627 Common - CDP-alcohol phosphatidyltransferase Mthe_0310 85 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 116754035 Nonpathogen - NMD3 Mthe_0723 33 COG1499 NMD3, NMD protein affecting ribosome stability and mRNA decay Translation, ribosomal structure and biogenesis 116754979 Common - Carbonic anhydrases/acetyltransferases isoleucine patch superfamily-like Mthe_1691 184 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 116754947 Nonpathogen - hypothetical protein Mthe_1659 1 None None None 116753620 Common - putative signal transduction protein with CBS domains Mthe_0303 169 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 116754954 Common - protein of unknown function DUF201 Mthe_1666 45 COG2232 COG2232, Predicted ATP-dependent carboligase related to biotin carboxylase General function prediction only 116753646 Nonpathogen - hypothetical protein Mthe_0330 3 None None None 116753938 Nonpathogen - hypothetical protein Mthe_0625 1 None None None 116753334 Common - MoaD family protein Mthe_0009 22 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 116753368 Nonpathogen - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Mthe_0043 1 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 116754676 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit G Mthe_1379 13 COG4064 MtrG, Tetrahydromethanopterin S-methyltransferase, subunit G Coenzyme metabolism 116754515 Nonpathogen - ADP-specific phosphofructokinase Mthe_1214 8 COG4809 COG4809, Archaeal ADP-dependent phosphofructokinase/glucokinase Carbohydrate transport and metabolism 116754081 Common - thermosome Mthe_0769 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 116754594 Nonpathogen - hypothetical protein Mthe_1294 1 None None None 116754834 Common - Phosphoribosylanthranilate isomerase Mthe_1540 193 COG0135 TrpF, Phosphoribosylanthranilate isomerase Amino acid transport and metabolism 116754497 Common - acetate--CoA ligase Mthe_1194 216 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 116754985 Common - protein of unknown function DUF255 Mthe_1697 105 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 116753882 Nonpathogen - Coenzyme-B sulfoethylthiotransferase Mthe_0569 14 COG4058 McrA, Methyl coenzyme M reductase, alpha subunit Coenzyme metabolism 116754851 Common - CRISPR-associated protein Cas1 Mthe_1559 104 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 116754840 Common - peptidylprolyl isomerase, FKBP-type Mthe_1547 153 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 116754899 Nonpathogen - V-type ATP synthase subunit F Mthe_1610 20 COG1436 NtpG, Archaeal/vacuolar-type H+-ATPase subunit F Energy production and conversion 116753879 Nonpathogen - hypothetical protein Mthe_0566 1 None None None 116753705 Nonpathogen - hypothetical protein Mthe_0390 1 None None None 116754484 Common - putative deoxyhypusine synthase Mthe_1180 63 COG1899 DYS1, Deoxyhypusine synthase Posttranslational modification, protein turnover, chaperones 116754209 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Mthe_0899 158 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 116753613 Common - hypothetical protein Mthe_0296 30 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 116754902 Nonpathogen - H+-transporting two-sector ATPase, C subunit Mthe_1613 1 None None None 116754614 Common - ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent Mthe_1314 229 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 116754799 Nonpathogen - FeoA family protein Mthe_1505 1 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 116754078 Nonpathogen - hypothetical protein Mthe_0766 16 COG4008 COG4008, Predicted metal-binding transcription factor Transcription 116754949 Nonpathogen - PUA domain containing protein Mthe_1661 31 COG1549 COG1549, Queuine tRNA-ribosyltransferases, contain PUA domain Translation, ribosomal structure and biogenesis 116754546 Common - Rubredoxin-type Fe(Cys)4 protein Mthe_1245 175 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 116753835 Common - adenine deaminase Mthe_0522 69 COG1001 AdeC, Adenine deaminase Nucleotide transport and metabolism 116754977 Common - hypothetical protein Mthe_1689 14 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 116754961 Common - polysaccharide biosynthesis protein Mthe_1673 64 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 116753984 Common - Na+/solute symporter Mthe_0672 175 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 116754422 Common - transposase, IS605 OrfB family Mthe_1117 77 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 116753665 Common - Radical SAM domain protein Mthe_0350 116 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116754025 Common - alanine dehydrogenase Mthe_0713 101 COG2423 COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog Amino acid transport and metabolism 116753420 Nonpathogen - putative transcriptional regulator, AsnC family Mthe_0096 1 COG1522 Lrp, Transcriptional regulators Transcription 116753723 Common - Wyosine base formation Mthe_0408 35 COG0731 COG0731, Fe-S oxidoreductases Energy production and conversion 116754283 Nonpathogen - molydopterin dinucleotide-binding region Mthe_0976 16 COG1153 FwdD, Formylmethanofuran dehydrogenase subunit D Energy production and conversion 116754077 Common - conserved repeat domain Mthe_0765 16 None None None 116755007 Common - ribosomal protein S17 Mthe_1719 205 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 116753725 Nonpathogen - nucleoside recognition domain protein Mthe_0410 16 COG3366 COG3366, Uncharacterized protein conserved in archaea Function unknown 116754664 Nonpathogen - RNase P subunit p30 Mthe_1367 14 COG1603 RPP1, RNase P/RNase MRP subunit p30 Translation, ribosomal structure and biogenesis 116753773 Common - Sua5/YciO/YrdC/YwlC family protein Mthe_0460 242 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 116754671 Common - protein of unknown function UPF0027 Mthe_1374 119 COG1690 RtcB, Uncharacterized conserved protein Function unknown 116754549 Common - response regulator receiver protein Mthe_1248 68 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 116754130 Common trkA potassium transporter peripheral membrane component Mthe_0819 166 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 116753699 Common - multi-sensor hybrid histidine kinase Mthe_0384 226 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116753327 Nonpathogen - hypothetical protein Mthe_0002 2 None None None 116754509 Common - Carbohydrate-binding and sugar hydrolysis Mthe_1206 43 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 116754461 Common - integral membrane protein Mthe_1157 21 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 116753345 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Mthe_0020 68 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 116754626 Nonpathogen - hypothetical protein Mthe_1326 1 COG3654 Doc, Prophage maintenance system killer protein General function prediction only 116754107 Common - trehalose-6-phosphate synthase Mthe_0796 9 COG0380 OtsA, Trehalose-6-phosphate synthase Carbohydrate transport and metabolism 116755012 Common rps19p 30S ribosomal protein S19P Mthe_1724 127 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 116753811 Nonpathogen - hypothetical protein Mthe_0498 14 COG4029 COG4029, Uncharacterized protein conserved in archaea Function unknown 116754186 Nonpathogen - PRC-barrel domain protein Mthe_0876 19 COG1873 COG1873, Uncharacterized conserved protein Function unknown 116754724 Nonpathogen - hypothetical protein Mthe_1427 1 None None None 116754139 Common - phosphomethylpyrimidine kinase Mthe_0828 223 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 116754197 Common - ABC transporter related Mthe_0887 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 116754875 Common - hypothetical protein Mthe_1583 80 COG1738 COG1738, Uncharacterized conserved protein Function unknown 116754580 Common - NHL repeat containing protein Mthe_1280 73 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 116753698 Common - cyclase family protein Mthe_0383 83 COG1878 COG1878, Predicted metal-dependent hydrolase General function prediction only 116754889 Nonpathogen - hypothetical protein Mthe_1599 4 None None None 116754144 Common - Phosphopyruvate hydratase Mthe_0833 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 116754800 Common - imidazoleglycerol phosphate synthase, cyclase subunit Mthe_1506 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 116754565 Common - anaerobic ribonucleoside-triphosphate reductase Mthe_1264 103 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 116754903 Common - V-type ATPase, 116 kDa subunit Mthe_1614 47 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 116754884 Common - periplasmic binding protein Mthe_1593 119 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 116753855 Common - aminotransferase, class I and II Mthe_0542 240 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 116754937 Common - pyruvate ferredoxin oxidoreductase subunit gamma Mthe_1648 58 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 116754011 Nonpathogen - hypothetical protein Mthe_0699 21 COG2150 COG2150, Predicted regulator of amino acid metabolism, contains ACT domain General function prediction only 116754093 Common - aminotransferase, class V Mthe_0781 177 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 116754383 Nonpathogen - Xylose isomerase domain protein TIM barrel Mthe_1078 11 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116754340 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Mthe_1034 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 116754279 Common - transposase, IS4 family protein Mthe_0969 26 None None None 116753965 Common - HAD-superfamily subfamily IIA hydrolase like protein Mthe_0653 110 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 116754957 Common - ABC-2 type transporter Mthe_1669 140 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 116753914 Common - putative signal transduction protein with CBS domains Mthe_0601 141 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 116753564 Common - flavoprotein Mthe_0245 17 COG1036 COG1036, Archaeal flavoproteins Energy production and conversion 116754018 Nonpathogen - amino acid-binding ACT domain protein Mthe_0706 15 COG1707 COG1707, ACT domain-containing protein General function prediction only 116753476 Common - transcriptional regulator, XRE family Mthe_0154 80 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 116754414 Common - response regulator receiver protein Mthe_1109 164 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116754053 Common - nitrogen-fixing NifU domain protein Mthe_0741 157 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 116754060 Common - hypothetical protein Mthe_0748 3 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 116754778 Common - metallophosphoesterase Mthe_1483 114 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 116754685 Nonpathogen - hypothetical protein Mthe_1388 21 COG2403 COG2403, Predicted GTPase General function prediction only 116753927 Nonpathogen - hypothetical protein Mthe_0614 1 None None None 116753545 Common - Zn-dependent hydrolase of the beta-lactamase fold Mthe_0225 92 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 116754585 Nonpathogen - hypothetical protein Mthe_1285 2 COG2168 DsrH, Uncharacterized conserved protein involved in oxidation of intracellular sulfur Inorganic ion transport and metabolism 116754273 Common - putative transmembrane protein Mthe_0963 6 None None None 116754813 Common - protein of unknown function DUF167 Mthe_1519 18 COG1872 COG1872, Uncharacterized conserved protein Function unknown 116754915 Common - periplasmic copper-binding Mthe_1626 37 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 116754313 Common - putative RNA methylase Mthe_1006 49 COG1041 COG1041, Predicted DNA modification methylase DNA replication, recombination, and repair 116754401 Common - molybdopterin oxidoreductase Mthe_1096 141 COG1029 FwdB, Formylmethanofuran dehydrogenase subunit B Energy production and conversion 116753593 Nonpathogen - Ribonucleoprotein complex SRP, Srp19 component Mthe_0274 30 COG1400 SEC65, Signal recognition particle 19 kDa protein Intracellular trafficking and secretion 116753390 Nonpathogen - hypothetical protein Mthe_0066 4 None None None 116753976 Nonpathogen - hypothetical protein Mthe_0664 1 None None None 116754996 Common rps5p 30S ribosomal protein S5P Mthe_1708 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 116754755 Common - oxidoreductase domain protein Mthe_1459 164 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116754773 Common - DNA mismatch repair protein MutL Mthe_1478 191 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 116754454 Common - Thioredoxin-disulfide reductase Mthe_1150 248 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 116753778 Nonpathogen - protein of unknown function DUF75 Mthe_0465 23 COG2047 COG2047, Uncharacterized protein (ATP-grasp superfamily) General function prediction only 116753827 Nonpathogen - hypothetical protein Mthe_0514 1 None None None 116753971 Nonpathogen - DNA polymerase II small subunit Mthe_0659 24 COG1311 HYS2, Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B DNA replication, recombination, and repair 116754261 Common - acylphosphatases-like Mthe_0951 25 COG1254 AcyP, Acylphosphatases Energy production and conversion 116754118 Common valS valyl-tRNA synthetase Mthe_0807 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116754408 Common - ABC transporter related Mthe_1103 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 116753358 Common rps12P 30S ribosomal protein S12P Mthe_0033 204 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 116753747 Common - Radical SAM domain protein Mthe_0433 139 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 116753380 Nonpathogen - Gas vesicle synthesis family protein Mthe_0056 11 None None None 116754046 Nonpathogen - hypothetical protein Mthe_0734 17 None None None 116753366 Nonpathogen - triosephosphate isomerase Mthe_0041 35 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 116754351 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding Mthe_1045 31 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 116753654 Nonpathogen - hypothetical protein Mthe_0338 1 None None None 116753607 Common - acetyl-CoA decarbonylase/synthase complex subunit delta Mthe_0288 20 COG2069 CdhD, CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein) Energy production and conversion 116753546 Common - GMP synthase subunit B Mthe_0226 238 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 116754374 Common - Methyltransferase type 11 Mthe_1068 170 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116754606 Common - branched-chain amino acid aminotransferase Mthe_1306 218 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 116754657 Nonpathogen rpl37ae 50S ribosomal protein L37Ae Mthe_1360 34 COG1997 RPL43A, Ribosomal protein L37AE/L43A Translation, ribosomal structure and biogenesis 116754182 Common - aminotransferase, class V Mthe_0872 241 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 116754193 Common - protein of unknown function UPF0153 Mthe_0883 17 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 116754792 Nonpathogen - Oligosaccharyl transferase, STT3 subunit Mthe_1498 14 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 116754321 Nonpathogen - hypothetical protein Mthe_1014 9 None None None 116753601 Common - putative RNA methylase, NOL1/NOP2/sun family Mthe_0282 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 116753867 Common - CoA-binding domain protein Mthe_0554 143 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 116753744 Common - band 7 protein Mthe_0430 202 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 116754826 Nonpathogen - hypothetical protein Mthe_1532 5 COG1933 COG1933, Archaeal DNA polymerase II, large subunit DNA replication, recombination, and repair 116754170 Common - transposase, IS4 family protein Mthe_0860 26 None None None 116753625 Common - protein of unknown function DUF77 Mthe_0308 26 COG0011 COG0011, Uncharacterized conserved protein Function unknown 116754797 Common - glycoside hydrolase 15-related Mthe_1503 63 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 116754111 Common - ski2-like helicase Mthe_0800 155 COG1204 COG1204, Superfamily II helicase General function prediction only 116753693 Common - ABC-2 type transporter Mthe_0378 110 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 116754303 Common - dimethyladenosine transferase Mthe_0996 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 116753577 Common - Nucleotidyl transferase Mthe_0258 212 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 116754600 Common - protein of unknown function DUF88 Mthe_1300 17 COG1432 COG1432, Uncharacterized conserved protein Function unknown 116753683 Common - tryptophanyl-tRNA synthetase Mthe_0368 45 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116754439 Common - putative transcriptional regulator, AsnC family Mthe_1134 57 COG1522 Lrp, Transcriptional regulators Transcription 116754713 Common - Peroxidase Mthe_1416 215 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116754554 Common - aspartate kinase Mthe_1253 235 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 116753554 Nonpathogen - hypothetical protein Mthe_0234 1 None None None 116754471 Nonpathogen - protein of unknown function DUF82 Mthe_1167 21 COG1656 COG1656, Uncharacterized conserved protein Function unknown 116753985 Common - dihydroxy-acid dehydratase Mthe_0673 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 116753772 Nonpathogen - transcriptional regulator, XRE family Mthe_0459 31 COG1813 COG1813, Predicted transcription factor, homolog of eukaryotic MBF1 Transcription 116754453 Nonpathogen - hypothetical protein Mthe_1149 1 None None None 116753600 Nonpathogen - hypothetical protein Mthe_0281 1 None None None 116754223 Common - formate dehydrogenase, alpha subunit Mthe_0913 200 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 116754952 Nonpathogen - hypothetical protein Mthe_1664 1 None None None 116753472 Common - leucine rich repeat variant Mthe_0150 18 None None None 116753536 Common argS arginyl-tRNA synthetase Mthe_0216 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116753648 Nonpathogen rps28e 30S ribosomal protein S28e Mthe_0332 33 COG2053 RPS28A, Ribosomal protein S28E/S33 Translation, ribosomal structure and biogenesis 116754247 Common - Prephenate dehydratase Mthe_0937 214 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 116753949 Common - CRISPR-associated protein Cas4 Mthe_0637 23 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 116754780 Nonpathogen - hypothetical protein Mthe_1486 1 None None None 116754265 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Mthe_0955 168 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 116753411 Common - Tetratricopeptide TPR_2 repeat protein Mthe_0087 177 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116754847 Common - hypothetical protein Mthe_1555 9 None None None 116754123 Common - PHP C-terminal domain protein Mthe_0812 66 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 116753952 Common - CRISPR-associated protein Cas5, Hmari subtype Mthe_0640 16 None None None 116753940 Nonpathogen - hypothetical protein Mthe_0627 24 COG1633 COG1633, Uncharacterized conserved protein Function unknown 116753492 Nonpathogen - KH, type 1, domain protein Mthe_0171 32 COG1094 COG1094, Predicted RNA-binding protein (contains KH domains) General function prediction only 116754760 Nonpathogen - hypothetical protein Mthe_1464 1 None None None 116754695 Common - elongation factor Tu, domain 2 protein Mthe_1398 224 COG3276 SelB, Selenocysteine-specific translation elongation factor Translation, ribosomal structure and biogenesis 116753456 Nonpathogen - hypothetical protein Mthe_0134 1 None None None 116754863 Nonpathogen - hypothetical protein Mthe_1571 33 COG2118 COG2118, DNA-binding protein General function prediction only 116754533 Common - DEAD/DEAH box helicase domain protein Mthe_1232 213 COG1202 COG1202, Superfamily II helicase, archaea-specific General function prediction only 116754240 Common - magnesium-translocating P-type ATPase Mthe_0930 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 116754772 Common - DNA mismatch repair protein MutS Mthe_1477 204 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 116754234 Nonpathogen - hypothetical protein Mthe_0924 1 None None None 116753896 Nonpathogen - hypothetical protein Mthe_0583 1 None None None 116754723 Nonpathogen - tRNA (guanine-N(2)-)-methyltransferase Mthe_1426 38 COG1867 TRM1, N2,N2-dimethylguanosine tRNA methyltransferase Translation, ribosomal structure and biogenesis 116753464 Common cbiD cobalt-precorrin-6A synthase Mthe_0142 88 COG1903 CbiD, Cobalamin biosynthesis protein CbiD Coenzyme metabolism 116753402 Common - Porphyromonas-type peptidyl-arginine deiminase Mthe_0078 212 COG2957 COG2957, Peptidylarginine deiminase and related enzymes Amino acid transport and metabolism 116753757 Common - periplasmic binding protein Mthe_0444 123 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 116753480 Common - F420-dependent oxidoreductase, putative Mthe_0158 44 COG1478 COG1478, Uncharacterized conserved protein Function unknown 116753329 Nonpathogen - RNA polymerase, dimerisation Mthe_0004 10 COG1761 RPB11, DNA-directed RNA polymerase, subunit L Transcription 116753634 Common - TraB family protein Mthe_0317 39 COG1916 COG1916, Uncharacterized homolog of PrgY (pheromone shutdown protein) Function unknown 116754973 Nonpathogen - HPr kinase Mthe_1685 3 COG1493 HprK, Serine kinase of the HPr protein, regulates carbohydrate metabolism Signal transduction mechanisms 116754109 Nonpathogen - hypothetical protein Mthe_0798 7 None None None 116753330 Nonpathogen - exosome complex RNA-binding protein Csl4 Mthe_0005 23 COG1096 COG1096, Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain) Translation, ribosomal structure and biogenesis 116753512 Common - lipolytic enzyme, G-D-S-L family Mthe_0191 89 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116754513 Common - N-6 DNA methylase Mthe_1211 160 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 116754463 Common - beta-lactamase domain protein Mthe_1159 44 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 116753995 Nonpathogen - Fe-S cluster domain protein Mthe_0683 14 COG2000 COG2000, Predicted Fe-S protein General function prediction only 116754526 Common - purine phosphorylase, family 2 Mthe_1225 161 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 116753641 Common - acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase Mthe_0325 219 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116754575 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Mthe_1275 139 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 116754883 Common - periplasmic binding protein Mthe_1591 122 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 116754061 Common - protein of unknown function UPF0153 Mthe_0749 27 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 116753503 Nonpathogen - hypothetical protein Mthe_0182 3 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 116753483 Common - chorismate synthase Mthe_0161 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 116753479 Common - thiamine pyrophosphate enzyme domain protein TPP-binding Mthe_0157 110 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 116753433 Common - (R)-citramalate synthase Mthe_0109 214 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 116753385 Common - gas vesicle synthesis protein GvpA Mthe_0061 22 None None None 116754736 Nonpathogen - hypothetical protein Mthe_1440 1 None None None 116753748 Common - cobaltochelatase, CobN subunit Mthe_0434 89 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 116753594 Nonpathogen - protein of unknown function DUF211 Mthe_0275 23 COG1888 COG1888, Uncharacterized protein conserved in archaea Function unknown 116754868 Common - methyl-viologen-reducing hydrogenase, delta subunit Mthe_1576 125 COG1148 HdrA, Heterodisulfide reductase, subunit A and related polyferredoxins Energy production and conversion 116754706 Common - RNA 2'-phosphotransferase-like protein Mthe_1409 42 COG1859 KptA, RNA:NAD 2'-phosphotransferase Translation, ribosomal structure and biogenesis 116753427 Nonpathogen - hypothetical protein Mthe_0103 1 None None None 116754256 Nonpathogen - hypothetical protein Mthe_0946 3 COG1254 AcyP, Acylphosphatases Energy production and conversion 116754660 Nonpathogen - exosome complex RNA-binding protein Rrp4 Mthe_1363 24 COG1097 RRP4, RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain) Translation, ribosomal structure and biogenesis 116753846 Common - DEAD/H associated domain protein Mthe_0533 167 COG1201 Lhr, Lhr-like helicases General function prediction only 116754430 Common hemC porphobilinogen deaminase Mthe_1125 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 116754220 Nonpathogen - hypothetical protein Mthe_0910 1 None None None 116754705 Nonpathogen - hypothetical protein Mthe_1408 2 None None None 116753791 Common rps2P 30S ribosomal protein S2 Mthe_0478 150 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 116753926 Common - AAA family ATPase, CDC48 subfamily Mthe_0613 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 116754177 Common - efflux transporter, putative, hydrophobe/amphiphile efflux-3 (HAE3) family Mthe_0867 118 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 116754027 Common - Na+/solute symporter Mthe_0715 59 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 116754360 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Mthe_1054 175 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 116753706 Nonpathogen - hypothetical protein Mthe_0391 2 None None None 116753533 Common - glutamine amidotransferase, class-II Mthe_0213 79 COG0067 GltB, Glutamate synthase domain 1 Amino acid transport and metabolism 116754782 Common - hypothetical protein Mthe_1488 11 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116754966 Common - glycosyl transferase, group 1 Mthe_1678 129 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116753854 Nonpathogen - hypothetical protein Mthe_0541 4 None None None 116753939 Nonpathogen - putative translation factor pelota Mthe_0626 33 COG1537 PelA, Predicted RNA-binding proteins General function prediction only 116754054 Nonpathogen - Non-histone chromosomal MC1 Mthe_0742 8 None None None 116753477 Common - AMP-dependent synthetase and ligase Mthe_0155 227 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 116754082 Nonpathogen - hypothetical protein Mthe_0770 5 None None None 116754583 Nonpathogen - hypothetical protein Mthe_1283 1 None None None 116754812 Nonpathogen - hypothetical protein Mthe_1518 5 COG1933 COG1933, Archaeal DNA polymerase II, large subunit DNA replication, recombination, and repair 116753569 Common - protein tyrosine phosphatase Mthe_0250 146 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 116753730 Common - translation initiation factor IF-2 subunit alpha Mthe_0416 137 COG1093 SUI2, Translation initiation factor 2, alpha subunit (eIF-2alpha) Translation, ribosomal structure and biogenesis 116753734 Nonpathogen - DNA primase small subunit Mthe_0420 32 COG1467 PRI1, Eukaryotic-type DNA primase, catalytic (small) subunit DNA replication, recombination, and repair 116754628 Common - phosphatidylserine decarboxylase related protein Mthe_1330 91 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 116753924 Nonpathogen - domain of unknown function DUF1743 Mthe_0611 33 COG1571 COG1571, Predicted DNA-binding protein containing a Zn-ribbon domain General function prediction only 116754334 Nonpathogen - DNA polymerase sliding clamp Mthe_1027 34 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 116754970 Common - phosphoserine phosphatase SerB Mthe_1682 167 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 116754318 Common - anaerobic ribonucleoside-triphosphate reductase activating protein Mthe_1011 109 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 116753696 Nonpathogen - hypothetical protein Mthe_0381 1 None None None 116754016 Common - phosphate ABC transporter, inner membrane subunit PstA Mthe_0704 234 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 116754611 Nonpathogen - hypothetical protein Mthe_1311 1 None None None 116754801 Common - imidazole glycerol phosphate synthase, glutamine amidotransferase subunit Mthe_1507 215 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 116754633 Common - serine phosphatase Mthe_1335 31 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 116753974 Common - putative transcriptional regulator, CopG family Mthe_0662 66 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 116753446 Common - hypothetical protein Mthe_0124 78 COG2078 AMMECR1, Uncharacterized conserved protein Function unknown 116754990 Common - putative rRNA pseudouridine synthase Mthe_1702 241 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 116754122 Common - PBS lyase HEAT domain protein repeat-containing protein Mthe_0811 67 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 116754997 Nonpathogen rpl18p 50S ribosomal protein L18P Mthe_1709 34 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 116754832 Common - Radical SAM N-terminal domain protein Mthe_1538 73 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116754040 Common - CRISPR-associated protein Cas4 Mthe_0728 26 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 116754866 Common - putative heterodisulfide reductase, C subunit Mthe_1574 52 COG1150 HdrC, Heterodisulfide reductase, subunit C Energy production and conversion 116754567 Common - proteasome-activating nucleotidase Mthe_1266 249 COG1222 RPT1, ATP-dependent 26S proteasome regulatory subunit Posttranslational modification, protein turnover, chaperones 116753718 Nonpathogen - hypothetical protein Mthe_0403 14 COG1571 COG1571, Predicted DNA-binding protein containing a Zn-ribbon domain General function prediction only 116754905 Common - Ribulose-bisphosphate carboxylase Mthe_1616 68 COG1850 RbcL, Ribulose 1,5-bisphosphate carboxylase, large subunit Carbohydrate transport and metabolism 116753942 Common - orotidine 5'-phosphate decarboxylase Mthe_0629 177 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 116753585 Nonpathogen - hypothetical protein Mthe_0266 16 COG3277 GAR1, RNA-binding protein involved in rRNA processing Translation, ribosomal structure and biogenesis 116753360 Common - formate dehydrogenase family accessory protein FdhD Mthe_0035 137 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 116754696 Common - alpha-glucan phosphorylases Mthe_1399 150 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 116754742 Nonpathogen - transcriptional regulator, XRE family Mthe_1446 32 COG1395 COG1395, Predicted transcriptional regulator Transcription 116754621 Common - DNA-directed RNA polymerase subunit E' Mthe_1321 44 COG1095 RPB7, DNA-directed RNA polymerase, subunit E' Transcription 116754354 Common - tyrosyl-tRNA synthetase Mthe_1048 206 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116753991 Nonpathogen - pyruvate formate-lyase activating enzyme Mthe_0679 12 COG4012 COG4012, Uncharacterized protein conserved in archaea Function unknown 116753562 Nonpathogen - hypothetical protein Mthe_0243 10 COG4081 COG4081, Uncharacterized protein conserved in archaea Function unknown 116754343 Common - Methyltransferase type 12 Mthe_1037 27 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116753618 Common - CBS domain containing membrane protein Mthe_0301 115 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 116754988 Nonpathogen - hypothetical protein Mthe_1700 1 None None None 116754923 Nonpathogen - flap endonuclease-1 Mthe_1634 34 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 116754716 Nonpathogen rpl12p 50S ribosomal protein L12P Mthe_1419 33 COG2058 RPP1A, Ribosomal protein L12E/L44/L45/RPP1/RPP2 Translation, ribosomal structure and biogenesis 116753912 Common - DNA topoisomerase VI subunit B Mthe_0599 34 COG1389 COG1389, DNA topoisomerase VI, subunit B DNA replication, recombination, and repair 116754573 Common - Parallel beta-helix repeat Mthe_1273 44 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 116753960 Nonpathogen - CRISPR-associated protein, Cmr3 family Mthe_0648 11 COG1769 COG1769, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 116753387 Common - gas vesicle synthesis protein GvpA Mthe_0063 22 None None None 116754396 Common - carbohydrate kinase, YjeF related protein Mthe_1091 217 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 116754914 Common - protein of unknown function DUF39 Mthe_1625 34 COG1900 COG1900, Uncharacterized conserved protein Function unknown 116755013 Common rpl2p 50S ribosomal protein L2P Mthe_1725 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 116754359 Common - respiratory-chain NADH dehydrogenase, subunit 1 Mthe_1053 189 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 116754540 Common - peptidase M24 Mthe_1239 232 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 116754872 Common - non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family Mthe_1580 236 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 116753919 Nonpathogen - competence-like protein Mthe_0606 12 None None None 116754894 Nonpathogen - hypothetical protein Mthe_1605 14 COG4022 COG4022, Uncharacterized protein conserved in archaea Function unknown 116754075 Nonpathogen - hypothetical protein Mthe_0763 1 None None None 116754448 Common - protein of unknown function DUF763 Mthe_1144 32 COG1415 COG1415, Uncharacterized conserved protein Function unknown 116754004 Common - Rhodanese domain protein Mthe_0692 97 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 116753775 Common - thymidine phosphorylase Mthe_0462 124 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 116754215 Common - heavy metal translocating P-type ATPase Mthe_0905 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 116754935 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Mthe_1646 133 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 116754500 Common - ATPase associated with various cellular activities, AAA_3 Mthe_1197 17 COG0714 COG0714, MoxR-like ATPases General function prediction only 116753813 Common - ABC transporter related Mthe_0500 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 116753667 Common - TspO and MBR like proteins Mthe_0352 64 COG3476 COG3476, Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) Signal transduction mechanisms 116754596 Common - protein of unknown function DUF1458 Mthe_1296 34 COG3360 COG3360, Uncharacterized conserved protein Function unknown 116753825 Common - protein of unknown function UPF0066 Mthe_0512 97 COG1720 COG1720, Uncharacterized conserved protein Function unknown 116754663 Nonpathogen - Ribonuclease P-related protein Mthe_1366 13 COG1369 POP5, RNase P/RNase MRP subunit POP5 Translation, ribosomal structure and biogenesis 116753848 Common - SufBD protein Mthe_0535 188 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 116754535 Nonpathogen - hypothetical protein Mthe_1234 10 COG4860 COG4860, Uncharacterized protein conserved in archaea Function unknown 116753721 Common - apurinic endonuclease Apn1 Mthe_0406 98 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 116754855 Nonpathogen - hypothetical protein Mthe_1563 1 None None None 116754385 Common - UTP-glucose-1-phosphate uridylyltransferase GalU Mthe_1080 233 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 116754506 Common - binding-protein-dependent transport systems inner membrane component Mthe_1203 199 COG4662 TupA, ABC-type tungstate transport system, periplasmic component Coenzyme metabolism 116754323 Common - protein of unknown function DUF64 Mthe_1016 15 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 116754115 Nonpathogen - hypothetical protein Mthe_0804 4 COG4742 COG4742, Predicted transcriptional regulator Transcription 116754873 Common - RNA-binding S4 domain protein Mthe_1581 134 COG1189 COG1189, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 116754227 Common - protein of unknown function DUF214 Mthe_0917 113 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 116754153 Nonpathogen - riboflavin synthase Mthe_0842 22 COG1731 COG1731, Archaeal riboflavin synthase Coenzyme metabolism 116754733 Nonpathogen - Protein of unknown function DUF1621 Mthe_1436 14 COG2450 COG2450, Uncharacterized conserved protein Function unknown 116754943 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit H Mthe_1654 17 COG1962 MtrH, Tetrahydromethanopterin S-methyltransferase, subunit H Coenzyme metabolism 116753369 Common - geranylgeranyl reductase Mthe_0044 125 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 116753788 Common - aspartate/glutamate/uridylate kinase Mthe_0475 45 COG1608 COG1608, Predicted archaeal kinase General function prediction only 116754184 Nonpathogen - hypothetical protein Mthe_0874 1 None None None 116753983 Common - geranylgeranyl reductase Mthe_0671 114 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 116753885 Nonpathogen - Methyl-coenzyme M reductase, beta subunit Mthe_0572 14 COG4054 McrB, Methyl coenzyme M reductase, beta subunit Coenzyme metabolism 116753783 Common - replication factor C large subunit Mthe_0470 221 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 116754768 Common - Integral membrane protein TerC Mthe_1472 94 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 116753715 Common - hypothetical protein Mthe_0400 40 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 116754133 Common rps10p 30S ribosomal protein S10P Mthe_0822 242 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 116753930 Common - fructose-bisphosphate aldolase Mthe_0617 80 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 116754311 Common - adenosylhomocysteinase Mthe_1004 177 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 116753660 Common - periplasmic binding protein Mthe_0344 10 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 116754616 Nonpathogen - hypothetical protein Mthe_1316 1 None None None 116753346 Common - protein of unknown function Met10 Mthe_0021 52 COG2520 COG2520, Predicted methyltransferase General function prediction only 116753373 Common hemA glutamyl-tRNA reductase Mthe_0049 179 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 116754072 Nonpathogen - hypothetical protein Mthe_0760 1 None None None 116754666 Nonpathogen - 50S ribosomal protein L15e Mthe_1369 34 COG1632 RPL15A, Ribosomal protein L15E Translation, ribosomal structure and biogenesis 116753351 Nonpathogen rpoH DNA-directed RNA polymerase subunit H Mthe_0026 33 COG2012 RPB5, DNA-directed RNA polymerase, subunit H, RpoH/RPB5 Transcription 116754036 Nonpathogen - Protein of unknown function DUF424 Mthe_0724 18 COG2412 COG2412, Uncharacterized conserved protein Function unknown 116754960 Common - helicase c2 Mthe_1672 99 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 116753817 Common - Tetratricopeptide TPR_2 repeat protein Mthe_0504 122 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116754511 Nonpathogen - restriction endonuclease S subunits Mthe_1208 2 None None None 116754164 Common - 3-isopropylmalate dehydratase, small subunit Mthe_0853 211 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 116754784 Common - Radical SAM domain protein Mthe_1490 103 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 116754803 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase Mthe_1509 130 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 116754148 Nonpathogen - translation elongation factor aEF-1 beta Mthe_0837 30 COG2092 EFB1, Translation elongation factor EF-1beta Translation, ribosomal structure and biogenesis 116754033 Common - AAA family ATPase, CDC48 subfamily Mthe_0721 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 116754403 Common - Formylmethanofuran dehydrogenase Mthe_1098 48 COG2218 FwdC, Formylmethanofuran dehydrogenase subunit C Energy production and conversion 116754305 Nonpathogen - hypothetical protein Mthe_0998 1 None None None 116754225 Common - formate dehydrogenase, alpha subunit Mthe_0915 216 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 116753494 Common - Hydantoinase/oxoprolinase Mthe_0173 24 COG1548 COG1548, Predicted transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 116753413 Nonpathogen - orotate phosphoribosyltransferase Mthe_0089 24 COG0856 COG0856, Orotate phosphoribosyltransferase homologs Nucleotide transport and metabolism 116755006 Common rpl14p 50S ribosomal protein L14P Mthe_1718 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 116754933 Nonpathogen - IMP cyclohydrolase Mthe_1644 13 COG3363 COG3363, Archaeal IMP cyclohydrolase Nucleotide transport and metabolism 116754288 Nonpathogen - heterodisulfide reductase, subunit E Mthe_0981 5 COG2181 NarI, Nitrate reductase gamma subunit Energy production and conversion 116754608 Common - aspartate aminotransferase Mthe_1308 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 116754357 Common - NADH-quinone oxidoreductase, B subunit Mthe_1051 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 116754693 Nonpathogen - protein of unknown function DUF125, transmembrane Mthe_1396 6 COG1814 COG1814, Uncharacterized membrane protein Function unknown 116753570 Common - Radical SAM domain protein Mthe_0251 57 COG4277 COG4277, Predicted DNA-binding protein with the Helix-hairpin-helix motif General function prediction only 116753364 Nonpathogen - hypothetical protein Mthe_0039 3 None None None 116754009 Nonpathogen - hypothetical protein Mthe_0697 1 None None None 116754103 Nonpathogen - Mov34 family protein Mthe_0792 21 COG1310 COG1310, Predicted metal-dependent protease of the PAD1/JAB1 superfamily General function prediction only 116753592 Nonpathogen - hypothetical protein Mthe_0273 1 None None None 116753355 Common - DNA-directed RNA polymerase subunit A'' Mthe_0030 248 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 116754289 Nonpathogen - hypothetical protein Mthe_0982 10 COG4738 COG4738, Predicted transcriptional regulator Transcription 116754929 Common - prolyl-tRNA synthetase Mthe_1640 235 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116753951 Common - CRISPR-associated protein, Csh2 family Mthe_0639 54 COG3649 COG3649, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 116754659 Common - exosome complex exonuclease Rrp41 Mthe_1362 233 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 116754741 Common - argininosuccinate synthase Mthe_1445 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 116754002 Common - hypothetical protein Mthe_0690 21 COG4273 COG4273, Uncharacterized conserved protein Function unknown 116754099 Common - 3-isopropylmalate dehydratase Mthe_0788 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 116754790 Common pheS phenylalanyl-tRNA synthetase subunit alpha Mthe_1496 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 116754372 Common - ABC transporter related Mthe_1066 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116753652 Common - pyruvate carboxyltransferase Mthe_0336 189 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 116754787 Common - PAS/PAC sensor signal transduction histidine kinase Mthe_1493 223 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 116754195 Common radA DNA repair and recombination protein RadA Mthe_0885 218 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 116753691 Nonpathogen - hypothetical protein Mthe_0376 17 COG2248 COG2248, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 116753869 Nonpathogen - protein of unknown function DUF134 Mthe_0556 4 COG1342 COG1342, Predicted DNA-binding proteins General function prediction only 116754232 Common - Radical SAM domain protein Mthe_0922 97 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 116754244 Common - peptidase M42 family protein Mthe_0934 88 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 116754975 Common - putative PAS/PAC sensor protein Mthe_1687 21 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 116754437 Common - hypothetical protein Mthe_1132 48 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 116753808 Nonpathogen - hypothetical protein Mthe_0495 14 COG4051 COG4051, Uncharacterized protein conserved in archaea Function unknown 116753572 Common - protein of unknown function DUF124 Mthe_0253 77 COG2013 COG2013, Uncharacterized conserved protein Function unknown 116753552 Nonpathogen - small nuclear ribonucleoprotein Mthe_0232 32 COG1958 LSM1, Small nuclear ribonucleoprotein (snRNP) homolog Transcription 116753908 Common - DNA topoisomerase I Mthe_0595 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 116753559 Nonpathogen - conserved repeat domain Mthe_0240 3 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 116754959 Nonpathogen - hypothetical protein Mthe_1671 10 COG1470 COG1470, Predicted membrane protein Function unknown 116753743 Common - Methyltransferase type 12 Mthe_0429 58 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 116753821 Nonpathogen - protein of unknown function DUF512 Mthe_0508 14 COG1625 COG1625, Fe-S oxidoreductase, related to NifB/MoaA family Energy production and conversion 116753605 Common - uncharacterized domain 1 protein Mthe_0286 49 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 116754711 Nonpathogen - hypothetical protein Mthe_1414 3 None None None 116754551 Nonpathogen - DNA polymerase II large subunit Mthe_1250 25 COG1933 COG1933, Archaeal DNA polymerase II, large subunit DNA replication, recombination, and repair 116753793 Nonpathogen - DNA-directed RNA polymerase subunit N Mthe_0480 34 COG1644 RPB10, DNA-directed RNA polymerase, subunit N (RpoN/RPB10) Transcription 116754645 Nonpathogen - hypothetical protein Mthe_1348 1 None None None 116753833 Common - aliphatic sulfonates family ABC transporter, periplsmic ligand-binding protein Mthe_0520 130 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 116754455 Common - Radical SAM domain protein Mthe_1151 28 COG1244 COG1244, Predicted Fe-S oxidoreductase General function prediction only 116754830 Common - arginine decarboxylase Mthe_1536 109 COG1166 SpeA, Arginine decarboxylase (spermidine biosynthesis) Amino acid transport and metabolism 116754753 Common - UDP-glucose/GDP-mannose dehydrogenase Mthe_1457 205 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 116754744 Common - nitroreductase Mthe_1448 189 COG0778 NfnB, Nitroreductase Energy production and conversion 116754173 Nonpathogen - hypothetical protein Mthe_0863 1 None None None 116753531 Common - glutamate synthase, alpha subunit domain protein Mthe_0211 117 COG0070 GltB, Glutamate synthase domain 3 Amino acid transport and metabolism 116754253 Common - protein of unknown function UPF0047 Mthe_0943 121 COG0432 COG0432, Uncharacterized conserved protein Function unknown 116754734 Nonpathogen - ZPR1-related zinc finger protein Mthe_1437 29 COG1779 COG1779, C4-type Zn-finger protein General function prediction only 116753934 Common - phosphate uptake regulator, PhoU Mthe_0621 197 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 116754217 Nonpathogen - Rubredoxin-type Fe(Cys)4 protein Mthe_0907 17 COG4802 FtrB, Ferredoxin-thioredoxin reductase, catalytic subunit Energy production and conversion 116753383 Nonpathogen - hypothetical protein Mthe_0059 3 None None None 116753860 Nonpathogen - Protein of unknown function DUF460 Mthe_0547 26 COG2433 COG2433, Uncharacterized conserved protein Function unknown 116754378 Nonpathogen - hypothetical protein Mthe_1072 1 None None None 116754141 Nonpathogen - hypothetical protein Mthe_0830 9 COG2083 COG2083, Uncharacterized protein conserved in archaea Function unknown 116754858 Nonpathogen rplX 50S ribosomal protein LX Mthe_1566 5 COG2157 RPL20A, Ribosomal protein L20A (L18A) Translation, ribosomal structure and biogenesis 116754179 Nonpathogen - hypothetical protein Mthe_0869 1 None None None 116754172 Common - CTP synthetase Mthe_0862 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 116754128 Common pgk phosphoglycerate kinase Mthe_0817 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 116754703 Nonpathogen - hypothetical protein Mthe_1406 1 None None None 116753339 Common - Phosphoribosylaminoimidazole carboxylase Mthe_0014 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 116753544 Nonpathogen - hypothetical protein Mthe_0224 2 None None None 116754063 Nonpathogen - hypothetical protein Mthe_0751 2 None None None 116753910 Common - peptidase S16, Lon-like protease Mthe_0597 205 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 116754714 Nonpathogen - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Mthe_1417 17 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 116753988 Common - histone deacetylase superfamily Mthe_0676 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 116754531 Nonpathogen - regulatory protein, ArsR Mthe_1230 3 None None None 116754436 Nonpathogen - hypothetical protein Mthe_1131 4 None None None 116754391 Nonpathogen - hypothetical protein Mthe_1086 9 COG4069 COG4069, Uncharacterized protein conserved in archaea Function unknown 116754291 Nonpathogen - hypothetical protein Mthe_0984 1 None None None 116753762 Common - Magnesium chelatase Mthe_0449 89 COG1239 ChlI, Mg-chelatase subunit ChlI Coenzyme metabolism 116753632 Common - thiamine biosynthesis protein ThiC Mthe_0315 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 116753755 Common - ABC transporter related Mthe_0442 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 116754290 Nonpathogen - hypothetical protein Mthe_0983 4 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 116754504 Nonpathogen - hypothetical protein Mthe_1201 18 COG1356 COG1356, Uncharacterized protein conserved in archaea Function unknown 116753408 Common - ammonium transporter Mthe_0084 202 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 116753801 Common - ADP-ribosylation/Crystallin J1 Mthe_0488 82 COG1397 DraG, ADP-ribosylglycohydrolase Posttranslational modification, protein turnover, chaperones 116754031 Nonpathogen - Protein of unknown function DUF473 Mthe_0719 13 COG1935 COG1935, Uncharacterized conserved protein Function unknown 116754729 Common - bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase Mthe_1432 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 116754700 Common - S-adenosylmethionine synthetase Mthe_1403 43 COG1812 MetK, Archaeal S-adenosylmethionine synthetase Amino acid transport and metabolism 116753701 Common - molybdenum cofactor synthesis domain Mthe_0386 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 116753769 Nonpathogen - Helix-turn-helix, type 11 domain protein Mthe_0456 1 COG4565 CitB, Response regulator of citrate/malate metabolism Transcription / Signal transduction mechanisms 116754556 Common - carbamoyl phosphate synthase small subunit Mthe_1255 234 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 116753409 Common - nitrogen regulatory protein P-II Mthe_0085 186 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 116753514 Common - tryptophan synthase subunit beta Mthe_0193 224 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 116753685 Nonpathogen - hypothetical protein Mthe_0370 1 None None None 116754369 Common - NAD-dependent epimerase/dehydratase Mthe_1063 231 COG1089 Gmd, GDP-D-mannose dehydratase Cell envelope biogenesis, outer membrane 116754120 Nonpathogen - F420-dependent methylenetetrahydromethanopterin dehydrogenase Mthe_0809 15 COG1927 Mtd, Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin dehydrogenase Energy production and conversion 116754367 Common - HesB/YadR/YfhF-family protein Mthe_1061 12 COG0316 IscA, Uncharacterized conserved protein Function unknown 116753481 Nonpathogen - protein of unknown function DUF121 Mthe_0159 20 COG1920 COG1920, Uncharacterized conserved protein Function unknown 116753523 Nonpathogen - metal-binding protein-like Mthe_0203 13 COG5423 COG5423, Predicted metal-binding protein Function unknown 116754570 Common - TrkA-N domain protein Mthe_1269 125 COG1226 Kch, Kef-type K+ transport systems, predicted NAD-binding component Inorganic ion transport and metabolism 116754967 Common - Nucleotidyl transferase Mthe_1679 226 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 116753583 Nonpathogen - hypothetical protein Mthe_0264 1 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 116754581 Common - Radical SAM domain protein Mthe_1281 106 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 116753560 Common - nicotinate-nucleotide pyrophosphorylase Mthe_0241 205 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 116754352 Common - DNA mismatch repair protein MutS domain protein Mthe_1046 162 COG1193 COG1193, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 116753353 Common - DNA-directed RNA polymerase subunit B' Mthe_0028 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 116754972 Common - Radical SAM domain protein Mthe_1684 185 COG1964 COG1964, Predicted Fe-S oxidoreductases General function prediction only 116753362 Common - ABC-2 type transporter Mthe_0037 199 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 116754085 Common lysK lysyl-tRNA synthetase Mthe_0773 77 COG1384 LysS, Lysyl-tRNA synthetase (class I) Translation, ribosomal structure and biogenesis 116754113 Common leuS leucyl-tRNA synthetase Mthe_0802 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116754569 Nonpathogen - hypothetical protein Mthe_1268 7 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 116754635 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Mthe_1338 135 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 116754398 Common - thiamine-monophosphate kinase Mthe_1093 204 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 116754751 Nonpathogen - hypothetical protein Mthe_1455 7 COG2169 Ada, Adenosine deaminase Nucleotide transport and metabolism 116754727 Common - imidazoleglycerol phosphate synthase, cyclase subunit Mthe_1430 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 116754932 Common - tetrahydromethanopterin formyltransferase Mthe_1643 24 COG2037 Ftr, Formylmethanofuran:tetrahydromethanopterin formyltransferase Energy production and conversion 116754100 Common - PHP C-terminal domain protein Mthe_0789 71 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 116753851 Nonpathogen - hypothetical protein Mthe_0538 2 None None None 116754190 Common - aminotransferase, class I and II Mthe_0880 240 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 116754999 Nonpathogen - Ribosomal protein L32e Mthe_1711 34 COG1717 RPL32, Ribosomal protein L32E Translation, ribosomal structure and biogenesis 116754817 Common - Methyltransferase type 11 Mthe_1523 178 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 116754486 Common - putative glycosyl transferase Mthe_1182 98 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116754495 Nonpathogen - hypothetical protein Mthe_1191 1 None None None 116754434 Common - deoxyuridine 5'-triphosphate nucleotidohydrolase Mthe_1129 32 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 116753429 Nonpathogen - Mur ligase, middle domain protein Mthe_0105 9 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 116754413 Common - transcriptional regulator, ArsR family Mthe_1108 160 COG0640 ArsR, Predicted transcriptional regulators Transcription 116753659 Common - transposase, IS4 family protein Mthe_0343 26 None None None 116754681 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit D Mthe_1384 14 COG4060 MtrD, Tetrahydromethanopterin S-methyltransferase, subunit D Coenzyme metabolism 116754560 Common - glycosyl transferase, family 2 Mthe_1259 163 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116754418 Common - dihydroorotase Mthe_1113 211 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 116754588 Nonpathogen - Fe-S cluster domain protein Mthe_1288 17 COG4871 COG4871, Uncharacterized protein conserved in archaea Function unknown 116754688 Common - acetyl-CoA acetyltransferase Mthe_1391 169 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 116754276 Common - transposase Mthe_0966 29 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 116753567 Common - phosphoribosylamine--glycine ligase Mthe_0248 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 116754344 Common - extracellular solute-binding protein, family 5 Mthe_1038 205 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 116754332 Nonpathogen - hypothetical protein Mthe_1025 1 None None None 116754181 Nonpathogen - hypothetical protein Mthe_0871 1 None None None 116753966 Nonpathogen - Protein of unknown function DUF509 Mthe_0654 14 COG1617 COG1617, Uncharacterized conserved protein Function unknown 116754631 Common - protein of unknown function DUF100 Mthe_1333 37 COG1980 COG1980, Archaeal fructose 1,6-bisphosphatase Carbohydrate transport and metabolism 116754014 Common - Protein involved in catabolism of external DNA-like Mthe_0702 35 COG2961 ComJ, Protein involved in catabolism of external DNA General function prediction only 116754880 Common - phosphodiesterase, MJ0936 family Mthe_1588 37 COG0622 COG0622, Predicted phosphoesterase General function prediction only 116754759 Nonpathogen - hypothetical protein Mthe_1463 1 None None None 116753558 Nonpathogen - Tubulin/FtsZ, GTPase Mthe_0239 20 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 116753444 Nonpathogen - hypothetical protein Mthe_0122 4 None None None 116753732 Nonpathogen rpl44e 50S ribosomal protein L44e Mthe_0418 34 COG1631 RPL42A, Ribosomal protein L44E Translation, ribosomal structure and biogenesis 116753729 Nonpathogen - Nucleolar RNA-binding protein Nop10p Mthe_0415 24 COG2260 COG2260, Predicted Zn-ribbon RNA-binding protein Translation, ribosomal structure and biogenesis 116754992 Nonpathogen - protein of unknown function DUF106, transmembrane Mthe_1704 20 COG1422 COG1422, Predicted membrane protein Function unknown 116754911 Common - TPR repeat-containing protein Mthe_1622 139 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116754316 Common - ATPase, P-type (transporting), HAD superfamily, subfamily IC Mthe_1009 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 116754326 Nonpathogen - hypothetical protein Mthe_1019 5 None None None 116754042 Common - chaperone protein DnaJ Mthe_0730 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 116753922 Common - hypothetical protein Mthe_0609 25 COG1901 COG1901, Uncharacterized conserved protein Function unknown 116753736 Common - Radical SAM domain protein Mthe_0422 120 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116754795 Common - shikimate 5-dehydrogenase Mthe_1501 225 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 116753972 Nonpathogen - signal sequence peptidase Mthe_0660 14 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 116753932 Common - acetyl-CoA hydrolase/transferase Mthe_0619 148 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 116754387 Common - conserved hypothetical protein 374 Mthe_1082 27 COG0392 COG0392, Predicted integral membrane protein Function unknown 116754524 Nonpathogen - hypothetical protein Mthe_1223 1 None None None 116754618 Nonpathogen - hypothetical protein Mthe_1318 1 None None None 116754393 Common - ATPase associated with various cellular activities, AAA_3 Mthe_1088 179 COG0714 COG0714, MoxR-like ATPases General function prediction only 116755003 Common rpl5p 50S ribosomal protein L5P Mthe_1715 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 116754879 Common - threonine synthase Mthe_1587 162 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 116754896 Common - V-type ATP synthase subunit D Mthe_1607 45 COG1394 NtpD, Archaeal/vacuolar-type H+-ATPase subunit D Energy production and conversion 116753501 Nonpathogen - translation initiation factor IF-2 subunit beta Mthe_0180 35 COG1601 GCD7, Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain Translation, ribosomal structure and biogenesis 116753662 Common - histidine biosynthesis Mthe_0347 33 COG1411 COG1411, Uncharacterized protein related to proFAR isomerase (HisA) General function prediction only 116754766 Nonpathogen - Protein of unknown function DUF128 Mthe_1470 16 COG1693 COG1693, Uncharacterized protein conserved in archaea Function unknown 116754155 Common - DNA ligase I, ATP-dependent Dnl1 Mthe_0844 111 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 116753887 Common - peptidylprolyl isomerase, FKBP-type Mthe_0574 128 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 116754731 Nonpathogen - Protein of unknown function DUF137 Mthe_1434 30 COG1701 COG1701, Uncharacterized protein conserved in archaea Function unknown 116753678 Common - O-phosphoseryl-tRNA synthetase Mthe_0363 92 COG2024 COG2024, Phenylalanyl-tRNA synthetase alpha subunit (archaeal type) Translation, ribosomal structure and biogenesis 116753815 Common - major facilitator superfamily MFS_1 Mthe_0502 235 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116754636 Common - formate dehydrogenase, alpha subunit Mthe_1339 204 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 116755016 Common rpl3p 50S ribosomal protein L3P Mthe_1728 98 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 116753958 Nonpathogen - CRISPR-associated protein, Cmr5 family Mthe_0646 4 COG3337 COG3337, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 116753874 Common - beta-lactamase domain protein Mthe_0561 59 COG1237 COG1237, Metal-dependent hydrolases of the beta-lactamase superfamily II General function prediction only 116754810 Common - Methyltransferase type 11 Mthe_1516 178 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 116753795 Common - ribosomal protein L13 Mthe_0482 103 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 116753422 Common - phosphoribosylformylglycinamidine synthase I Mthe_0098 232 COG0047 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain Nucleotide transport and metabolism 116754424 Nonpathogen - hypothetical protein Mthe_1119 1 None None None 116754229 Common - pyridoxine biosynthesis protein Mthe_0919 87 COG0214 SNZ1, Pyridoxine biosynthesis enzyme Coenzyme metabolism 116753717 Common - Indolepyruvate ferredoxin oxidoreductase Mthe_0402 66 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 116753831 Common - cation transporter Mthe_0518 133 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 116754038 Common - S-adenosylmethionine synthetase Mthe_0726 43 COG1812 MetK, Archaeal S-adenosylmethionine synthetase Amino acid transport and metabolism 116754545 Common - molybdopterin-guanine dinucleotide biosynthesis protein Mthe_1244 129 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 116753397 Common - Gas vesicle synthesis GvpLGvpF Mthe_0073 18 None None None 116753823 Common - extracellular solute-binding protein, family 5 Mthe_0510 208 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 116754070 Nonpathogen - hypothetical protein Mthe_0758 1 None None None 116754675 Nonpathogen - tetrahydromethanopterin S-methyltransferase subunit H Mthe_1378 17 COG1962 MtrH, Tetrahydromethanopterin S-methyltransferase, subunit H Coenzyme metabolism 116754542 Common - Glycine hydroxymethyltransferase Mthe_1241 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 116753838 Common - tungsten formylmethanofuran dehydrogenase, subunit C-like Mthe_0525 23 COG2218 FwdC, Formylmethanofuran dehydrogenase subunit C Energy production and conversion 116753917 Common - 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase Mthe_0604 211 COG1985 RibD, Pyrimidine reductase, riboflavin biosynthesis Coenzyme metabolism 116753777 Common - protein of unknown function DUF89 Mthe_0464 40 COG1578 COG1578, Uncharacterized conserved protein Function unknown 116754870 Nonpathogen - RNAse P, Rpr2/Rpp21 subunit Mthe_1578 19 COG2023 RPR2, RNase P subunit RPR2 Translation, ribosomal structure and biogenesis 116753856 Nonpathogen - CopG domain protein DNA-binding domain protein Mthe_0543 5 None None None 116754839 Nonpathogen - hypothetical protein Mthe_1546 1 None None None 116754056 Common - nitrite and sulphite reductase 4Fe-4S region Mthe_0744 155 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 116754205 Common secD preprotein translocase subunit SecD Mthe_0895 117 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 116754622 Nonpathogen - DNA-directed RNA polymerase subunit E, RpoE2 Mthe_1322 31 COG2093 COG2093, DNA-directed RNA polymerase, subunit E'' Transcription 116753415 Common - cobalt ABC transporter, inner membrane subunit CbiQ Mthe_0091 68 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 116754885 Common - transposase, IS4 family protein Mthe_1595 26 None None None 116754598 Common - 2-isopropylmalate synthase Mthe_1298 219 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 116753341 Nonpathogen - Radical SAM domain protein Mthe_0016 28 COG2108 COG2108, Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme General function prediction only 116754441 Common - aspartate-semialdehyde dehydrogenase Mthe_1136 194 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism