Solibacter usitatus Ellin6076, complete genome NC_008536 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 116623795 Common - protein of unknown function DUF6, transmembrane Acid_4707 17 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 116621566 Nonpathogen - hypothetical protein Acid_2448 2 None None None 116621462 Common - hypothetical protein Acid_2344 27 None None None 116622920 Common - putative transcriptional regulators, CopG/Arc/MetJ family Acid_3821 16 COG3609 COG3609, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain Transcription 116622385 Common - TonB-dependent receptor Acid_3279 22 None None None 116623629 Nonpathogen - hypothetical protein Acid_4541 1 None None None 116625193 Common - Tetratricopeptide TPR_2 repeat protein Acid_6138 50 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116619370 Common - methyltransferase small Acid_0228 90 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 116621060 Common - transcriptional regulator, IclR family Acid_1941 122 COG1414 IclR, Transcriptional regulator Transcription 116619928 Nonpathogen - hypothetical protein Acid_0800 2 None None None 116622304 Common - Thymidine kinase Acid_3198 48 COG1435 Tdk, Thymidine kinase Nucleotide transport and metabolism 116620280 Common - glycoside hydrolase 15-related protein Acid_1157 68 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 116626447 Common - glycosyl transferase, group 1 Acid_7409 214 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116626844 Common - Cna B domain protein Acid_7817 17 None None None 116622158 Nonpathogen - DinB family protein Acid_3050 1 COG2318 DinB, Uncharacterized protein conserved in bacteria Function unknown 116624423 Common - cytochrome c, class I Acid_5345 18 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 116626159 Common - glycosyl transferase, family 2 Acid_7119 179 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 116622677 Common - domain of unknown function DUF1730 Acid_3576 131 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 116623195 Common - Multidrug resistance efflux pump-like protein Acid_4102 121 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116623483 Common - serine/threonine protein kinase Acid_4393 154 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116626247 Common - DNA repair protein RecO Acid_7207 16 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 116621432 Common - glutaminase Acid_2314 3 None None None 116626689 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Acid_7661 187 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 116622570 Common - phosphoenolpyruvate carboxykinase Acid_3468 98 COG1866 PckA, Phosphoenolpyruvate carboxykinase (ATP) Energy production and conversion 116626106 Nonpathogen - hypothetical protein Acid_7064 7 COG5450 COG5450, Transcription regulator of the Arc/MetJ class Transcription 116625930 Nonpathogen - hypothetical protein Acid_6887 1 None None None 116626250 Common - O-methyltransferase, family 2 Acid_7210 50 None None None 116622968 Common - Xylose isomerase domain protein TIM barrel Acid_3871 3 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116626040 Common - major facilitator superfamily MFS_1 Acid_6998 19 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116621909 Common - PAS/PAC sensor hybrid histidine kinase Acid_2794 221 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116625672 Nonpathogen - hypothetical protein Acid_6621 1 None None None 116625946 Common - cytochrome c, class I Acid_6904 15 COG2857 CYT1, Cytochrome c1 Energy production and conversion 116623190 Nonpathogen - hypothetical protein Acid_4097 1 None None None 116625797 Common groEL chaperonin GroEL Acid_6747 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 116626529 Nonpathogen - hypothetical protein Acid_7492 1 None None None 116624270 Nonpathogen - hypothetical protein Acid_5188 1 None None None 116622122 Common - NAD-dependent epimerase/dehydratase Acid_3010 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116623168 Nonpathogen - hypothetical protein Acid_4074 20 COG5316 COG5316, Uncharacterized conserved protein Function unknown 116624441 Common - putative deoxyguanosinetriphosphate triphosphohydrolase Acid_5363 161 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 116621726 Nonpathogen - protein of unknown function DUF296 Acid_2608 2 COG1661 COG1661, Predicted DNA-binding protein with PD1-like DNA-binding motif General function prediction only 116620969 Common - hypothetical protein Acid_1850 3 None None None 116620789 Nonpathogen - hypothetical protein Acid_1670 1 None None None 116622229 Common - Pyrrolo-quinoline quinone Acid_3122 76 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116621599 Nonpathogen - hypothetical protein Acid_2481 1 None None None 116619402 Nonpathogen - hypothetical protein Acid_0261 1 None None None 116619166 Common - multi-sensor signal transduction histidine kinase Acid_0021 220 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 116621919 Common - hypothetical protein Acid_2804 18 COG4299 COG4299, Uncharacterized protein conserved in bacteria Function unknown 116621523 Common - Cna B domain protein Acid_2405 22 COG4932 COG4932, Predicted outer membrane protein Cell envelope biogenesis, outer membrane 116623033 Common - phosphoglucomutase Acid_3937 217 COG0033 Pgm, Phosphoglucomutase Carbohydrate transport and metabolism 116622579 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding Acid_3477 51 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 116619647 Common - DNA repair protein RecN Acid_0508 202 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 116619680 Nonpathogen - hypothetical protein Acid_0545 1 None None None 116620544 Common - translation initiation factor IF-3 Acid_1422 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 116621410 Common - transcriptional regulator, TrmB Acid_2292 96 COG4189 COG4189, Predicted transcriptional regulator Transcription 116621779 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Acid_2661 110 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116624428 Nonpathogen - hypothetical protein Acid_5350 1 None None None 116626277 Common - hypothetical protein Acid_7237 16 None None None 116619670 Nonpathogen - hypothetical protein Acid_0533 1 None None None 116624452 Common - response regulator receiver modulated CheB methylesterase Acid_5374 200 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 116624961 Common - Arginine--tRNA ligase Acid_5890 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116620298 Common - amino acid permease-associated region Acid_1175 193 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116622419 Nonpathogen - hypothetical protein Acid_3316 4 None None None 116622999 Common - hypothetical protein Acid_3903 5 None None None 116623200 Nonpathogen - hypothetical protein Acid_4107 1 None None None 116621250 Common - protein of unknown function UPF0066 Acid_2131 99 COG1720 COG1720, Uncharacterized conserved protein Function unknown 116621303 Common - transcriptional regulator, LysR family Acid_2184 187 COG0583 LysR, Transcriptional regulator Transcription 116625593 Nonpathogen - hypothetical protein Acid_6542 10 COG5304 COG5304, Uncharacterized protein conserved in bacteria Function unknown 116621361 Common - Xylose isomerase domain protein TIM barrel Acid_2242 14 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116623987 Common - hypothetical protein Acid_4899 22 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 116619720 Common - serine/threonine protein kinase Acid_0585 148 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116624527 Common - NAD-dependent epimerase/dehydratase Acid_5451 219 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116619462 Common - microcompartments protein Acid_0321 46 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 116624062 Nonpathogen - hypothetical protein Acid_4976 3 None None None 116624375 Common - hypothetical protein Acid_5296 43 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116622186 Common - acyl-CoA dehydrogenase domain protein Acid_3078 150 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 116622918 Nonpathogen - CHRD domain containing protein Acid_3819 1 None None None 116622140 Common - transcriptional regulator, TetR family Acid_3032 15 COG1309 AcrR, Transcriptional regulator Transcription 116624930 Common - molybdopterin oxidoreductase Acid_5857 190 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 116622338 Common - hypothetical protein Acid_3232 14 None None None 116625136 Common - short-chain dehydrogenase/reductase SDR Acid_6073 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116620161 Common - lysyl-tRNA synthetase Acid_1034 249 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 116620916 Nonpathogen - hypothetical protein Acid_1797 4 COG3867 COG3867, Arabinogalactan endo-1,4-beta-galactosidase Carbohydrate transport and metabolism 116622107 Common - putative esterase Acid_2994 59 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 116626063 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_7021 12 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116621852 Common - glycosyl hydrolase, family 88 Acid_2735 20 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 116624666 Common - Cytochrome-c oxidase Acid_5590 174 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 116623473 Nonpathogen - cytochrome oxidase assembly Acid_4383 1 COG1612 CtaA, Uncharacterized protein required for cytochrome oxidase assembly Posttranslational modification, protein turnover, chaperones 116626955 Common - PHP C-terminal domain protein Acid_7932 128 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 116624659 Nonpathogen - hypothetical protein Acid_5583 1 None None None 116620584 Common - hypothetical protein Acid_1463 3 None None None 116621975 Common - Aldehyde reductase Acid_2860 149 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 116622116 Common - Cna B domain protein Acid_3004 24 None None None 116623086 Common - lipolytic enzyme, G-D-S-L family Acid_3990 58 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116624615 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_5539 171 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116624929 Common - serine/threonine protein kinase Acid_5856 184 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116624670 Nonpathogen - hypothetical protein Acid_5594 1 None None None 116622625 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Acid_3524 109 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116623207 Nonpathogen - hypothetical protein Acid_4114 1 None None None 116625053 Nonpathogen - hypothetical protein Acid_5983 1 None None None 116623341 Common - geranylgeranyl reductase Acid_4250 90 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 116626331 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_7291 167 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116625021 Nonpathogen - hypothetical protein Acid_5951 1 None None None 116626816 Common - type II and III secretion system protein Acid_7789 133 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 116624980 Nonpathogen - von Willebrand factor, type A Acid_5910 3 None None None 116621383 Common - protein of unknown function DUF1549 Acid_2264 5 None None None 116621354 Common - large conductance mechanosensitive channel protein Acid_2235 31 COG1970 MscL, Large-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 116620962 Common - prolyl-tRNA synthetase Acid_1843 231 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116622992 Common - Antibiotic biosynthesis monooxygenase Acid_3895 23 COG1359 COG1359, Uncharacterized conserved protein Function unknown 116623453 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Acid_4362 4 None None None 116625548 Common - protein of unknown function DUF214 Acid_6495 16 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620353 Common araD L-ribulose-5-phosphate 4-epimerase Acid_1230 121 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 116623759 Nonpathogen - hypothetical protein Acid_4671 1 None None None 116619832 Common - oxidoreductase domain protein Acid_0702 138 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116623300 Common - two component, sigma54 specific, transcriptional regulator, Fis family Acid_4207 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116623972 Nonpathogen - hypothetical protein Acid_4884 4 None None None 116623580 Nonpathogen - hypothetical protein Acid_4490 1 None None None 116620534 Common - type II secretion system protein E Acid_1412 222 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 116626094 Nonpathogen - hypothetical protein Acid_7052 1 None None None 116624625 Nonpathogen - hypothetical protein Acid_5549 2 None None None 116626321 Nonpathogen - hypothetical protein Acid_7281 1 None None None 116626777 Nonpathogen - hypothetical protein Acid_7750 4 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 116624973 Common - response regulator receiver protein Acid_5903 210 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 116625469 Nonpathogen - hypothetical protein Acid_6415 4 None None None 116622889 Common - NADPH-dependent FMN reductase Acid_3790 64 COG0431 COG0431, Predicted flavoprotein General function prediction only 116623980 Common - protein of unknown function, zinc metallopeptidase putative Acid_4892 87 COG2321 COG2321, Predicted metalloprotease General function prediction only 116626908 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Acid_7885 186 COG2876 AroA, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 116621471 Common - Guanylate kinase Acid_2353 213 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 116622594 Common - hypothetical protein Acid_3492 19 None None None 116623023 Nonpathogen - Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)-like protein Acid_3927 6 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 116626162 Common - Tetratricopeptide TPR_2 repeat protein Acid_7122 40 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116626475 Nonpathogen - hypothetical protein Acid_7438 1 None None None 116621398 Common - hypothetical protein Acid_2280 4 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 116622826 Nonpathogen - hypothetical protein Acid_3726 2 None None None 116626695 Nonpathogen - Mov34/MPN/PAD-1 family protein Acid_7667 1 None None None 116626744 Common - Gluconolactonase Acid_7716 64 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116625979 Nonpathogen - hypothetical protein Acid_6937 1 None None None 116619839 Common - Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit Acid_0709 78 COG4656 RnfC, Predicted NADH:ubiquinone oxidoreductase, subunit RnfC Energy production and conversion 116622783 Nonpathogen - hypothetical protein Acid_3682 6 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116623803 Common - glycosyl transferase, group 1 Acid_4715 32 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116620935 Common - excinuclease ABC, A subunit Acid_1816 239 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 116620042 Common - Dihydrolipoyllysine-residue succinyltransferase Acid_0914 196 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 116620927 Common - TonB-dependent receptor Acid_1808 118 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 116626138 Common - ribose-phosphate pyrophosphokinase Acid_7096 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 116623308 Common - Feruloyl esterase Acid_4215 21 None None None 116619232 Nonpathogen - Electron transfer flavoprotein alpha subunit-like protein Acid_0087 2 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 116620691 Common - MiaB-like tRNA modifying enzyme YliG Acid_1571 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 116626373 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Acid_7333 232 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 116625686 Common - sugar transferase Acid_6635 179 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 116625155 Common - hypothetical protein Acid_6095 14 None None None 116620342 Common rplT 50S ribosomal protein L20 Acid_1219 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 116619355 Common - TonB-dependent receptor Acid_0213 24 None None None 116620655 Common - peptidase M23B Acid_1535 138 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 116620847 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_1728 11 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116626534 Common - UDP-glucose 6-dehydrogenase Acid_7497 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 116621102 Nonpathogen - hypothetical protein Acid_1983 3 None None None 116624269 Nonpathogen - transcriptional regulator, PadR-like family Acid_5187 2 COG1695 COG1695, Predicted transcriptional regulators Transcription 116622370 Nonpathogen - hypothetical protein Acid_3264 1 None None None 116623106 Common - Alpha-L-arabinofuranosidase-like protein Acid_4010 30 COG3534 AbfA, Alpha-L-arabinofuranosidase Carbohydrate transport and metabolism 116619955 Common - ABC-3 protein Acid_0827 173 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 116620349 Common - phosphomethylpyrimidine kinase Acid_1226 218 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 116621083 Common - ASPIC/UnbV domain protein Acid_1964 27 None None None 116623518 Common - Enoyl-CoA hydratase/isomerase Acid_4428 179 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 116622361 Common - acetate kinase Acid_3255 161 COG0282 ackA, Acetate kinase Energy production and conversion 116625323 Nonpathogen - hypothetical protein Acid_6268 1 None None None 116623458 Nonpathogen - hypothetical protein Acid_4367 3 None None None 116624920 Common - transcriptional regulator, PadR-like family Acid_5846 37 COG1695 COG1695, Predicted transcriptional regulators Transcription 116625689 Common - BLUF domain protein Acid_6638 41 None None None 116621751 Common - Inosine/uridine-preferring nucleoside hydrolase Acid_2633 4 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 116625503 Common - glycosyl transferase, family 2 Acid_6450 53 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116621596 Common - arsenate reductase related protein Acid_2478 4 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 116625342 Common - hypothetical protein Acid_6287 67 COG1470 COG1470, Predicted membrane protein Function unknown 116625346 Common - Tetratricopeptide TPR_2 repeat protein Acid_6291 119 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116626738 Nonpathogen - SEFIR domain protein Acid_7710 5 None None None 116620957 Common - integral membrane protein TerC Acid_1838 56 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 116624048 Nonpathogen - Xylose isomerase domain protein TIM barrel Acid_4962 7 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116626748 Common gatB aspartyl/glutamyl-tRNA amidotransferase subunit B Acid_7720 213 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 116619620 Common - glycine dehydrogenase subunit 2 Acid_0481 172 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 116621883 Nonpathogen - hypothetical protein Acid_2766 1 None None None 116624932 Nonpathogen - hypothetical protein Acid_5859 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116619409 Common - putative ribonuclease BN Acid_0268 140 COG1295 Rbn, Predicted membrane protein Function unknown 116621842 Common - Carbohydrate-selective porin OprB Acid_2724 11 COG3659 OprB, Carbohydrate-selective porin Cell envelope biogenesis, outer membrane 116622151 Nonpathogen - hypothetical protein Acid_3043 6 None None None 116625939 Nonpathogen - hypothetical protein Acid_6897 6 COG2319 COG2319, FOG: WD40 repeat General function prediction only 116620915 Common - glycoside hydrolase, family 31 Acid_1796 82 COG1501 COG1501, Alpha-glucosidases, family 31 of glycosyl hydrolases Carbohydrate transport and metabolism 116623635 Common - Phytanoyl-CoA dioxygenase Acid_4547 17 COG5285 COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin Secondary metabolites biosynthesis, transport, and catabolism 116626931 Common - secretion protein HlyD family protein Acid_7908 158 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116620923 Common - Ribonuclease III Acid_1804 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 116625375 Common - Heat shock protein 70 Acid_6320 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 116620225 Common - integral membrane sensor signal transduction histidine kinase Acid_1102 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116626837 Common - glycosyl transferase, group 1 Acid_7810 201 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116626169 Nonpathogen - Cupin 2, conserved barrel domain protein Acid_7129 8 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 116624313 Common - pyrimidine-nucleoside phosphorylase Acid_5231 118 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 116622256 Nonpathogen - hypothetical protein Acid_3149 2 None None None 116624364 Common - glycosyltransferase-like protein Acid_5285 85 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 116625199 Common - protein of unknown function DUF323 Acid_6144 103 COG1262 COG1262, Uncharacterized conserved protein Function unknown 116626353 Common - UDP-N-acetylmuramoylalanine--D-glutamate ligase Acid_7313 211 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 116622100 Common - TonB-dependent receptor Acid_2987 23 None None None 116626405 Common - Abortive infection protein Acid_7367 35 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 116623423 Nonpathogen - Redoxin domain protein Acid_4332 1 None None None 116622129 Common - Phosphoglycerate mutase Acid_3017 100 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 116619963 Common - formate dehydrogenase, gamma subunit Acid_0835 62 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 116623771 Nonpathogen - hypothetical protein Acid_4683 1 None None None 116626842 Common - hypothetical protein Acid_7815 16 None None None 116620910 Common - putative amino acid transporter Acid_1791 25 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 116621967 Nonpathogen - hypothetical protein Acid_2852 1 None None None 116624475 Nonpathogen - hypothetical protein Acid_5397 1 None None None 116619653 Common - Tetratricopeptide TPR_2 repeat protein Acid_0514 69 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 116620490 Common - serine/threonine protein kinase with TPR repeats Acid_1368 161 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116624677 Common - protein of unknown function DUF214 Acid_5601 18 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116626754 Nonpathogen - hypothetical protein Acid_7727 1 None None None 116620547 Nonpathogen - hypothetical protein Acid_1425 1 None None None 116624885 Common - Sel1 domain protein repeat-containing protein Acid_5809 91 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 116621376 Common - microcompartments protein Acid_2257 46 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 116622896 Nonpathogen - hypothetical protein Acid_3797 1 None None None 116623690 Nonpathogen - hypothetical protein Acid_4602 1 None None None 116621961 Nonpathogen - hypothetical protein Acid_2846 1 None None None 116621285 Common - permease for cytosine/purines, uracil, thiamine, allantoin Acid_2166 21 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 116622375 Common - aldo/keto reductase Acid_3269 201 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116621256 Common - Outer membrane protein/protective antigen OMA87-like protein Acid_2137 59 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 116620661 Common - transcriptional regulator, MerR family Acid_1541 118 COG0789 SoxR, Predicted transcriptional regulators Transcription 116619666 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Acid_0529 32 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 116620792 Common - 3-Oxoacyl-(acyl-carrier-protein (ACP)) synthase III C terminal domain protein Acid_1673 191 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 116620945 Common - peptidase S9, prolyl oligopeptidase active site domain protein Acid_1826 162 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116619641 Nonpathogen - hypothetical protein Acid_0502 2 None None None 116623294 Nonpathogen - hypothetical protein Acid_4201 1 None None None 116620114 Common - anthranilate synthase Acid_0987 231 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 116626767 Nonpathogen - hypothetical protein Acid_7740 3 None None None 116620609 Common - transcriptional repressor, CopY family Acid_1488 45 COG3682 COG3682, Predicted transcriptional regulator Transcription 116622408 Common - hypothetical protein Acid_3303 12 COG4334 COG4334, Uncharacterized protein conserved in bacteria Function unknown 116623064 Nonpathogen - hypothetical protein Acid_3968 1 None None None 116622523 Common - NLP/P60 protein Acid_3421 163 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 116624854 Common - putative ribonuclease BN Acid_5778 92 COG1295 Rbn, Predicted membrane protein Function unknown 116619934 Nonpathogen - hypothetical protein Acid_0806 1 None None None 116622147 Common - hypothetical protein Acid_3039 28 COG5649 COG5649, Uncharacterized conserved protein Function unknown 116623318 Nonpathogen - hypothetical protein Acid_4227 1 None None None 116620578 Nonpathogen - hypothetical protein Acid_1457 1 None None None 116623919 Common - Glutamate--ammonia ligase Acid_4831 230 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 116625583 Common - Xylose isomerase domain protein TIM barrel Acid_6532 6 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116621816 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_2698 42 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116625293 Nonpathogen - membrane protein Acid_6238 2 COG1238 COG1238, Predicted membrane protein Function unknown 116620735 Common - hypothetical protein Acid_1616 26 None None None 116619662 Common - Methyltransferase type 11 Acid_0525 159 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116623522 Common - ABC transporter related Acid_4432 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 116625150 Common - hypothetical protein Acid_6090 3 None None None 116619546 Common - hypothetical protein Acid_0405 3 None None None 116622449 Nonpathogen - hypothetical protein Acid_3347 1 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 116626412 Common - hypothetical protein Acid_7374 36 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 116622355 Common - cysteinyl-tRNA synthetase Acid_3249 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116621632 Common - hypothetical protein Acid_2514 3 None None None 116621405 Nonpathogen - hypothetical protein Acid_2287 1 None None None 116625613 Common - Zn finger protein HypA/HybF (possibly regulating hydrogenase expression)-like protein Acid_6562 47 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 116619950 Common - type I phosphodiesterase/nucleotide pyrophosphatase Acid_0822 18 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 116622712 Common - serine phosphatase Acid_3611 92 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 116620318 Nonpathogen - putative adenylyl cyclase CyaB Acid_1195 8 COG1437 CyaB, Adenylate cyclase, class 2 (thermophilic) Nucleotide transport and metabolism 116626110 Common - oxidoreductase domain protein Acid_7068 135 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116626146 Nonpathogen - hypothetical protein Acid_7105 1 None None None 116625913 Nonpathogen - hypothetical protein Acid_6870 9 None None None 116619912 Common - hypothetical protein Acid_0784 85 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 116625852 Common - IstB domain protein ATP-binding protein Acid_6806 110 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 116626286 Nonpathogen - hypothetical protein Acid_7246 1 None None None 116626856 Common - hypothetical protein Acid_7831 22 None None None 116626028 Common - Radical SAM domain protein Acid_6986 74 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116625720 Common - modification methylase, HemK family Acid_6669 222 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 116622061 Common - hypothetical protein Acid_2948 3 None None None 116625709 Common - peptidase S9, prolyl oligopeptidase active site domain protein Acid_6658 57 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116621885 Common - glycoside hydrolase, family 1 Acid_2768 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 116626640 Common - glycoside hydrolase, family 31 Acid_7605 82 COG1501 COG1501, Alpha-glucosidases, family 31 of glycosyl hydrolases Carbohydrate transport and metabolism 116626827 Common - NAD-dependent epimerase/dehydratase Acid_7800 87 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116621923 Common - hypothetical protein Acid_2808 14 None None None 116619458 Common - protein of unknown function DUF1223 Acid_0317 33 COG5429 COG5429, Uncharacterized secreted protein Function unknown 116622500 Common - amidohydrolase Acid_3398 67 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116625893 Common - serine/threonine protein kinase Acid_6847 188 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116622036 Common - aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead Acid_2921 83 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 116625650 Common - protein of unknown function DUF214 Acid_6599 154 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622729 Common - transcriptional regulator, AraC family Acid_3628 112 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 116623962 Nonpathogen - hypothetical protein Acid_4874 1 None None None 116626830 Common - hypothetical protein Acid_7803 25 COG4301 COG4301, Uncharacterized conserved protein Function unknown 116626020 Common - response regulator receiver protein Acid_6978 54 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116625486 Common - hypothetical protein Acid_6432 7 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 116621607 Common - protein of unknown function DUF214 Acid_2489 29 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620076 Nonpathogen - hypothetical protein Acid_0948 1 None None None 116622663 Common - hypothetical protein Acid_3562 56 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 116625240 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Acid_6185 23 None None None 116620124 Common - AMP-dependent synthetase and ligase Acid_0997 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116623656 Common - transport-associated Acid_4568 12 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 116624138 Common - DinB Acid_5054 5 COG2318 DinB, Uncharacterized protein conserved in bacteria Function unknown 116625210 Nonpathogen - hypothetical protein Acid_6155 1 None None None 116624115 Common - transcriptional regulator, MarR family Acid_5031 28 COG1846 MarR, Transcriptional regulators Transcription 116625900 Common - sulfatase Acid_6855 95 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116624649 Common - branched-chain amino acid aminotransferase Acid_5573 218 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 116624041 Common - peptidase M20 Acid_4955 132 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116622217 Nonpathogen - hypothetical protein Acid_3110 1 None None None 116622849 Nonpathogen - hypothetical protein Acid_3749 1 None None None 116624783 Common - WxcM domain protein, C-terminal domain protein Acid_5707 121 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 116623339 Common - cyanophycinase Acid_4248 27 COG4242 CphB, Cyanophycinase and related exopeptidases Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism 116624569 Common - intracellular protease, PfpI family Acid_5493 157 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 116620271 Common - putative esterase Acid_1148 54 COG4099 COG4099, Predicted peptidase General function prediction only 116624092 Common - hypothetical protein Acid_5007 34 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 116623411 Common - two component transcriptional regulator, winged helix family Acid_4320 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116623661 Nonpathogen - putative transcriptional regulator, XRE family Acid_4573 2 None None None 116619482 Common - flagellar motor switch protein FliG Acid_0341 125 COG1536 FliG, Flagellar motor switch protein Cell motility and secretion 116625031 Common - protein of unknown function DUF214 Acid_5961 53 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116626152 Common - protein of unknown function DUF214 Acid_7111 20 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623668 Common - beta-lactamase Acid_4580 149 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116625164 Nonpathogen - hypothetical protein Acid_6107 1 None None None 116622765 Common - hypothetical protein Acid_3664 4 None None None 116623465 Nonpathogen - hypothetical protein Acid_4375 1 None None None 116619971 Nonpathogen - hypothetical protein Acid_0843 1 None None None 116621260 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Acid_2141 227 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 116619385 Common - 3-oxoadipate enol-lactonase Acid_0244 167 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 116626647 Nonpathogen - hypothetical protein Acid_7613 1 None None None 116626913 Common - Indole-3-glycerol-phosphate synthase Acid_7890 217 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 116624541 Common - protein of unknown function DUF214 Acid_5465 40 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116625661 Common - serine/threonine protein kinase Acid_6610 154 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116626722 Nonpathogen - HEAT domain containing protein Acid_7694 3 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 116622583 Common - two component transcriptional regulator, LuxR family Acid_3481 207 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116624065 Common - 3D domain protein Acid_4979 19 COG3584 COG3584, Uncharacterized protein conserved in bacteria Function unknown 116619148 Common - DNA gyrase, B subunit Acid_0003 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 116621501 Nonpathogen - hypothetical protein Acid_2383 2 None None None 116621934 Nonpathogen - hypothetical protein Acid_2819 1 COG1512 COG1512, Beta-propeller domains of methanol dehydrogenase type General function prediction only 116621703 Nonpathogen - hypothetical protein Acid_2585 1 None None None 116620457 Common - protein of unknown function DUF419 Acid_1335 31 COG2315 MmcQ, Uncharacterized protein conserved in bacteria Function unknown 116621450 Common - heat shock protein Hsp20 Acid_2332 148 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 116626554 Common - serine/threonine protein kinase Acid_7517 168 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116621862 Common - chorismate synthase Acid_2745 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 116625835 Nonpathogen - hypothetical protein Acid_6788 1 None None None 116622606 Common - Rieske (2Fe-2S) domain protein Acid_3504 86 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 116621736 Nonpathogen - hypothetical protein Acid_2618 1 None None None 116621621 Common - arginine repressor, ArgR Acid_2503 78 COG1438 ArgR, Arginine repressor Transcription 116622347 Common - undecaprenyl diphosphate synthase Acid_3241 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 116619941 Common - aminotransferase, class I and II Acid_0813 237 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 116624393 Common - acriflavin resistance protein Acid_5314 178 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116626566 Common - beta-Ig-H3/fasciclin Acid_7529 68 COG2335 COG2335, Secreted and surface protein containing fasciclin-like repeats Cell envelope biogenesis, outer membrane 116619292 Nonpathogen - hypothetical protein Acid_0148 1 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 116624537 Nonpathogen - hypothetical protein Acid_5461 4 None None None 116620890 Common - prevent-host-death family protein Acid_1771 11 COG4118 Phd, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 116626398 Common - Enoyl-CoA hydratase/isomerase Acid_7358 180 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 116621512 Common - carbamoyl-phosphate synthase, small subunit Acid_2394 235 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 116621021 Nonpathogen - hypothetical protein Acid_1902 1 None None None 116625510 Common - natural resistance-associated macrophage protein Acid_6457 106 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 116620859 Common - Galactarate dehydratase Acid_1740 73 COG2721 UxaA, Altronate dehydratase Carbohydrate transport and metabolism 116621754 Common - efflux transporter, RND family, MFP subunit Acid_2636 165 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116622880 Nonpathogen - hypothetical protein Acid_3781 1 COG5028 COG5028, Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 Intracellular trafficking and secretion 116623467 Common - phosphonoacetate hydrolase Acid_4377 14 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 116625038 Nonpathogen - hypothetical protein Acid_5968 2 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 116619781 Nonpathogen - hypothetical protein Acid_0651 1 None None None 116621277 Common - carbohydrate kinase, YjeF related protein Acid_2158 211 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 116620431 Common - Radical SAM domain protein Acid_1309 81 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 116626465 Nonpathogen - hypothetical protein Acid_7428 1 None None None 116626127 Nonpathogen - hypothetical protein Acid_7085 1 None None None 116624103 Common - NADH dehydrogenase (quinone) Acid_5018 171 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 116621928 Common - protein of unknown function DUF214 Acid_2813 22 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623223 Nonpathogen - hypothetical protein Acid_4130 1 None None None 116622254 Common - peptidase domain protein Acid_3147 70 COG4995 COG4995, Uncharacterized protein conserved in bacteria Function unknown 116621864 Common - methionyl-tRNA formyltransferase Acid_2747 218 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 116622199 Common - O-methyltransferase, family 3 Acid_3091 105 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 116624133 Nonpathogen - hypothetical protein Acid_5049 9 None None None 116619271 Nonpathogen - hypothetical protein Acid_0127 3 COG1102 Cmk, Cytidylate kinase Nucleotide transport and metabolism 116623140 Common - TPR repeat-containing protein Acid_4046 80 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116626295 Common - transposase IS3/IS911 family protein Acid_7255 2 None None None 116623159 Common - RNA-binding S4 domain protein Acid_4065 110 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 116620703 Nonpathogen - hypothetical protein Acid_1583 1 None None None 116620668 Common - response regulator receiver protein Acid_1548 204 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 116623276 Common - protein of unknown function DUF891 Acid_4183 27 COG4679 COG4679, Phage-related protein Function unknown 116619747 Nonpathogen - hypothetical protein Acid_0613 1 None None None 116621906 Common - protein of unknown function DUF214 Acid_2791 110 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116626415 Nonpathogen - hypothetical protein Acid_7377 2 None None None 116619518 Common - putative dipeptidyl-peptidase III Acid_0377 12 None None None 116625833 Common - two component, sigma54 specific, transcriptional regulator, Fis family Acid_6786 221 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116620720 Common - type II and III secretion system protein Acid_1600 112 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 116621233 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_2114 142 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116621811 Common - hypothetical protein Acid_2693 17 None None None 116625641 Common - oxidoreductase domain protein Acid_6590 14 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116619278 Nonpathogen - hypothetical protein Acid_0134 1 None None None 116625028 Common - Xylose isomerase domain protein TIM barrel Acid_5958 30 COG4952 COG4952, Predicted sugar isomerase Cell envelope biogenesis, outer membrane 116619477 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_0336 9 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116619527 Nonpathogen - hypothetical protein Acid_0386 1 None None None 116621696 Common - protein of unknown function DUF55 Acid_2578 90 COG2947 COG2947, Uncharacterized conserved protein Function unknown 116625305 Nonpathogen - putative esterase Acid_6250 1 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 116625442 Common - protein of unknown function DUF1572 Acid_6387 8 None None None 116620996 Common - transcriptional regulator, ArsR family Acid_1877 51 COG0640 ArsR, Predicted transcriptional regulators Transcription 116623111 Common - two component transcriptional regulator, winged helix family Acid_4015 194 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116623825 Common - Cna B domain protein Acid_4737 21 None None None 116622012 Common - phage integrase family protein Acid_2897 24 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 116622403 Common - protein of unknown function DUF214 Acid_3297 100 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 116621011 Nonpathogen - isochorismatase hydrolase Acid_1892 2 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 116619154 Nonpathogen - hypothetical protein Acid_0009 1 None None None 116625256 Common - peptidase dimerisation domain protein Acid_6201 157 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116626000 Nonpathogen - biotin/lipoyl attachment domain-containing protein Acid_6958 2 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 116624446 Common - CheW protein Acid_5368 130 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 116621144 Common - trigger factor Acid_2025 216 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 116626660 Nonpathogen - hypothetical protein Acid_7629 1 None None None 116624026 Nonpathogen - hypothetical protein Acid_4938 6 COG2043 COG2043, Uncharacterized protein conserved in archaea Function unknown 116619349 Common - transcriptional regulator, LysR family Acid_0207 62 COG0583 LysR, Transcriptional regulator Transcription 116626634 Common - hypothetical protein Acid_7599 39 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116625857 Nonpathogen - hypothetical protein Acid_6811 1 None None None 116619208 Common - LamB/YcsF family protein Acid_0063 100 COG1540 COG1540, Uncharacterized proteins, homologs of lactam utilization protein B General function prediction only 116623171 Common - TonB-dependent receptor, plug Acid_4077 23 None None None 116623684 Nonpathogen - hypothetical protein Acid_4596 1 None None None 116620686 Common - hypothetical protein Acid_1566 3 None None None 116622220 Nonpathogen - hypothetical protein Acid_3113 1 None None None 116622545 Common - peptidase M61 domain protein Acid_3443 56 COG3975 COG3975, Predicted protease with the C-terminal PDZ domain General function prediction only 116624502 Common - Alanine dehydrogenase Acid_5426 165 COG0686 Ald, Alanine dehydrogenase Amino acid transport and metabolism 116624755 Nonpathogen - hypothetical protein Acid_5679 1 None None None 116621156 Nonpathogen - hypothetical protein Acid_2037 1 None None None 116624564 Common - transcriptional repressor, CopY family Acid_5488 27 COG3682 COG3682, Predicted transcriptional regulator Transcription 116620754 Nonpathogen - hypothetical protein Acid_1635 1 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 116623394 Common - signal transduction histidine kinase, LytS Acid_4303 102 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 116624835 Common - lipolytic enzyme, G-D-S-L family Acid_5759 16 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116624349 Common - 40-residue YVTN family beta-propeller repeat protein Acid_5269 68 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116624955 Common - cysteine synthase A Acid_5884 219 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 116626207 Common - hypothetical protein Acid_7167 19 None None None 116619693 Common - Methyltransferase type 12 Acid_0558 161 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116621308 Common - histidine kinase Acid_2189 149 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 116626793 Common - diacylglycerol kinase, catalytic region Acid_7766 111 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 116623838 Nonpathogen - Cupin 2, conserved barrel domain protein Acid_4750 1 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 116626760 Nonpathogen - hypothetical protein Acid_7733 1 None None None 116622517 Common - TonB family protein Acid_3415 20 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 116622860 Common - protein of unknown function DUF1501 Acid_3761 5 COG4102 COG4102, Uncharacterized protein conserved in bacteria Function unknown 116621547 Common - DGPFAETKE family protein Acid_2429 35 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 116623744 Common - putative colanic acid biosynthesis acetyltransferase WcaF Acid_4656 116 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 116620256 Common - DoxX family protein Acid_1133 3 None None None 116619601 Common - ATP synthase F1, delta subunit Acid_0462 171 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 116622909 Common - sodium/calcium exchanger membrane region Acid_3810 45 COG0387 ChaA, Ca2+/H+ antiporter Inorganic ion transport and metabolism 116624246 Nonpathogen - hypothetical protein Acid_5164 1 None None None 116625727 Nonpathogen - hypothetical protein Acid_6676 1 None None None 116622325 Common - glycosyl hydrolase Acid_3219 54 None None None 116625086 Nonpathogen - hypothetical protein Acid_6020 1 None None None 116619377 Common - ImpA domain protein Acid_0235 38 COG3515 COG3515, Uncharacterized protein conserved in bacteria Function unknown 116621173 Nonpathogen - hypothetical protein Acid_2054 2 None None None 116626174 Common - hypothetical protein Acid_7134 20 COG4365 COG4365, Uncharacterized protein conserved in bacteria Function unknown 116622508 Nonpathogen - acetate--CoA ligase Acid_3406 1 None None None 116624000 Nonpathogen - hypothetical protein Acid_4912 1 None None None 116623407 Nonpathogen - hypothetical protein Acid_4316 4 None None None 116623006 Common - protein of unknown function DUF214 Acid_3910 73 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623271 Common - ribonuclease, Rne/Rng family Acid_4178 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 116619441 Nonpathogen - hypothetical protein Acid_0300 1 None None None 116623435 Common - hypothetical protein Acid_4344 4 None None None 116620366 Common - Protein of unknown function DUF1592 Acid_1243 7 None None None 116622094 Common - hypothetical protein Acid_2981 8 None None None 116625106 Nonpathogen - hypothetical protein Acid_6042 1 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116626098 Common - Silent information regulator protein Sir2 Acid_7056 152 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 116625907 Nonpathogen - hypothetical protein Acid_6863 1 None None None 116622278 Common - hypothetical protein Acid_3172 19 COG4289 COG4289, Uncharacterized protein conserved in bacteria Function unknown 116626459 Common - transcription-repair coupling factor Acid_7421 232 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 116622004 Common - putative PAS/PAC sensor protein Acid_2889 129 COG2202 AtoS, FOG: PAS/PAC domain Signal transduction mechanisms 116626318 Common - Neurolysin Acid_7278 124 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 116620139 Common - RecA domain protein Acid_1012 215 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 116620905 Common gabD2 succinic semialdehyde dehydrogenase Acid_1786 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 116620356 Common - SSS sodium solute transporter superfamily Acid_1233 168 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 116623400 Common - Tetratricopeptide TPR_2 repeat protein Acid_4309 20 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116623706 Common - metal dependent phosphohydrolase Acid_4618 208 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 116626421 Nonpathogen - Tat (twin-arginine translocation) pathway signal sequence domain protein Acid_7383 2 None None None 116622091 Nonpathogen - Xylose isomerase domain protein TIM barrel Acid_2978 9 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116620384 Common - NAD-dependent epimerase/dehydratase Acid_1261 215 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116621409 Common - Activator of Hsp90 ATPase 1 family protein Acid_2291 63 COG3832 COG3832, Uncharacterized conserved protein Function unknown 116619181 Nonpathogen - hypothetical protein Acid_0036 2 None None None 116621042 Common - Glucose-6-phosphate isomerase Acid_1923 193 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 116619919 Nonpathogen - hypothetical protein Acid_0791 2 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 116621715 Common - transcriptional regulator, XRE family Acid_2597 38 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 116619677 Common - short-chain dehydrogenase/reductase SDR Acid_0540 235 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 116620616 Common - ABC transporter related Acid_1495 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116622226 Nonpathogen - hypothetical protein Acid_3119 1 None None None 116619714 Common - YdjC family protein Acid_0579 53 COG3394 COG3394, Uncharacterized protein conserved in bacteria Function unknown 116621936 Nonpathogen - hypothetical protein Acid_2821 1 None None None 116624155 Nonpathogen - hypothetical protein Acid_5071 1 None None None 116624803 Nonpathogen - hypothetical protein Acid_5727 2 None None None 116622010 Nonpathogen - hypothetical protein Acid_2895 2 None None None 116623589 Common - NAD-dependent epimerase/dehydratase Acid_4499 33 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116623531 Common - glycoside hydrolase, family 43 Acid_4441 38 COG3507 XynB, Beta-xylosidase Carbohydrate transport and metabolism 116626086 Common - integral membrane sensor signal transduction histidine kinase Acid_7044 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116626731 Common - SUF system FeS assembly protein, NifU family Acid_7703 168 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 116623619 Nonpathogen - protein of unknown function DUF214 Acid_4529 8 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116619774 Common - transposase, IS204/IS1001/IS1096/IS1165 family protein Acid_0644 61 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 116626326 Common - hypothetical protein Acid_7286 24 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 116623529 Common - protein of unknown function DUF214 Acid_4439 60 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116621093 Nonpathogen - putative acyl carrier protein Acid_1974 2 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116621167 Common - Xylose isomerase domain protein TIM barrel Acid_2048 12 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116619863 Common - hypothetical protein Acid_0735 3 None None None 116625538 Common - Multidrug resistance efflux pump-like protein Acid_6485 89 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116619609 Common - Ig family protein Acid_0470 49 None None None 116621985 Common - two component transcriptional regulator, LuxR family Acid_2870 219 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116625386 Common - drug resistance transporter, EmrB/QacA subfamily Acid_6331 225 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116625526 Common - Phosphomannomutase Acid_6473 243 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 116620050 Common - putative CoA-substrate-specific enzyme activase Acid_0922 65 COG1924 COG1924, Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) Lipid metabolism 116623336 Common - Tetratricopeptide TPR_2 repeat protein Acid_4245 32 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116626270 Common - hypothetical protein Acid_7230 3 None None None 116621047 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Acid_1928 3 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116623139 Common - major facilitator superfamily MFS_1 Acid_4045 115 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116620879 Common - tRNA/rRNA methyltransferase (SpoU) Acid_1760 202 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 116620569 Nonpathogen - hypothetical protein Acid_1447 1 None None None 116625969 Common - hydrogenase maturation protease Acid_6927 69 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 116626367 Nonpathogen - hypothetical protein Acid_7327 1 None None None 116619778 Common - ParB domain protein nuclease Acid_0648 10 COG1475 Spo0J, Predicted transcriptional regulators Transcription 116622264 Common - ribosomal protein L21 Acid_3158 184 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 116626257 Nonpathogen - hypothetical protein Acid_7217 1 None None None 116620295 Common - Phosphoglycerate mutase Acid_1172 8 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 116619305 Common - peptidase S9, prolyl oligopeptidase active site domain protein Acid_0161 124 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116622976 Common - NADH-quinone oxidoreductase, chain I Acid_3879 193 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 116621035 Common - protein of unknown function DUF214 Acid_1916 21 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622289 Common - metal dependent phosphohydrolase Acid_3183 31 COG2316 COG2316, Predicted hydrolase (HD superfamily) General function prediction only 116620654 Common - Endothelin-converting enzyme 1 Acid_1534 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 116624326 Common - ABC transporter related Acid_5244 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116620422 Common - GCN5-related N-acetyltransferase Acid_1299 46 COG3153 COG3153, Predicted acetyltransferase General function prediction only 116619705 Common - peptidase S41 Acid_0570 160 COG4946 COG4946, Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system Function unknown 116626632 Common - Beta-galactosidase Acid_7597 39 COG1874 LacA, Beta-galactosidase Carbohydrate transport and metabolism 116626202 Common - amino acid permease-associated region Acid_7162 88 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116622467 Common - protein of unknown function DUF899, thioredoxin family protein Acid_3365 29 COG4312 COG4312, Uncharacterized protein conserved in bacteria Function unknown 116622496 Common - Tetratricopeptide TPR_2 repeat protein Acid_3394 47 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116624372 Common - beta-lactamase Acid_5293 133 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116625991 Common - RND efflux system, outer membrane lipoprotein, NodT family Acid_6949 123 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116621666 Nonpathogen - hypothetical protein Acid_2548 2 None None None 116624873 Nonpathogen - hypothetical protein Acid_5797 1 None None None 116621995 Common - multi-sensor signal transduction histidine kinase Acid_2880 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116622488 Common - protein of unknown function DUF1214 Acid_3386 42 COG5361 COG5361, Uncharacterized conserved protein Function unknown 116625556 Common - phosphopentomutase Acid_6503 70 COG1015 DeoB, Phosphopentomutase Carbohydrate transport and metabolism 116623173 Common - hypothetical protein Acid_4080 18 None None None 116620209 Common - maf protein Acid_1082 199 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 116619876 Common - surface antigen (D15) Acid_0748 154 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 116621235 Nonpathogen - hypothetical protein Acid_2116 1 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116625397 Common - Pyrrolo-quinoline quinone Acid_6342 61 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116619861 Common - GrpE protein Acid_0733 230 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 116626083 Common - transposase IS116/IS110/IS902 family protein Acid_7041 86 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116624570 Common - Xylose isomerase domain protein TIM barrel Acid_5494 71 COG3622 Hfi, Hydroxypyruvate isomerase Carbohydrate transport and metabolism 116620217 Common - ribosomal protein L34 Acid_1093 8 COG0230 RpmH, Ribosomal protein L34 Translation, ribosomal structure and biogenesis 116625998 Common - Methylmalonyl-CoA mutase Acid_6956 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 116626607 Common - hypothetical protein Acid_7570 26 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 116625203 Common - Selenocysteine synthase (seryl-tRNASer selenium transferase)-like protein Acid_6148 30 COG1921 SelA, Selenocysteine synthase [seryl-tRNASer selenium transferase] Amino acid transport and metabolism 116623523 Nonpathogen - hypothetical protein Acid_4433 1 None None None 116624608 Common - ammonium transporter Acid_5532 202 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 116624540 Nonpathogen - hypothetical protein Acid_5464 5 None None None 116623859 Common - hypothetical protein Acid_4771 22 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 116621135 Common - RNA-directed DNA polymerase (Reverse transcriptase) Acid_2016 91 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 116626897 Common - integral membrane sensor signal transduction histidine kinase Acid_7874 223 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 116622748 Nonpathogen - hypothetical protein Acid_3647 2 None None None 116626112 Nonpathogen - hypothetical protein Acid_7070 1 None None None 116621249 Common - Alpha/beta hydrolase fold-3 domain protein Acid_2130 112 COG0657 Aes, Esterase/lipase Lipid metabolism 116621623 Common - ornithine carbamoyltransferase Acid_2505 237 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 116621643 Common - YD repeat protein Acid_2525 63 COG3209 RhsA, Rhs family protein Cell envelope biogenesis, outer membrane 116620773 Common - protein of unknown function DUF214 Acid_1654 73 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 116621542 Nonpathogen - FG-GAP repeat protein Acid_2424 3 None None None 116623084 Nonpathogen - hypothetical protein Acid_3988 1 None None None 116624864 Common - metallophosphoesterase Acid_5788 3 COG1409 Icc, Predicted phosphohydrolases General function prediction only 116623901 Common - FkbH like protein Acid_4813 32 COG3882 FkbH, Predicted enzyme involved in methoxymalonyl-ACP biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 116622823 Nonpathogen - hypothetical protein Acid_3723 5 None None None 116624408 Common - glucuronate isomerase Acid_5330 59 COG1904 UxaC, Glucuronate isomerase Carbohydrate transport and metabolism 116626303 Common - excinuclease ABC, A subunit Acid_7263 244 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 116619982 Common - daunorubicin resistance ABC transporter ATPase subunit Acid_0854 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116624460 Nonpathogen - hypothetical protein Acid_5382 1 None None None 116626224 Nonpathogen - hypothetical protein Acid_7184 4 None None None 116620391 Nonpathogen - hypothetical protein Acid_1268 1 None None None 116619589 Common - membrane protein of unknown function Acid_0450 73 COG1950 COG1950, Predicted membrane protein Function unknown 116622864 Common - response regulator receiver protein Acid_3765 174 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116625692 Common - ribosomal protein L28 Acid_6641 81 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 116620134 Common - RNP-1 like RNA-binding protein Acid_1007 66 COG0724 COG0724, RNA-binding proteins (RRM domain) General function prediction only 116625002 Common - protein of unknown function DUF214 Acid_5932 92 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116621537 Common - (2Fe-2S)-binding domain protein Acid_2419 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 116623079 Common - hypothetical protein Acid_3983 60 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116623560 Nonpathogen - protein of unknown function UPF0153 Acid_4470 2 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 116625100 Nonpathogen - hypothetical protein Acid_6036 1 None None None 116619813 Common - oxidoreductase domain protein Acid_0683 155 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116621388 Nonpathogen - hypothetical protein Acid_2269 5 None None None 116625753 Common - putative transaldolase Acid_6703 158 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 116626645 Nonpathogen - hypothetical protein Acid_7611 1 None None None 116619855 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Acid_0727 52 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 116622396 Common - integral membrane sensor hybrid histidine kinase Acid_3290 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116622616 Common - protein of unknown function DUF214 Acid_3515 16 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623184 Nonpathogen - hypothetical protein Acid_4091 1 None None None 116620062 Common - YD repeat protein Acid_0934 9 None None None 116622610 Common - cytochrome C oxidase, mono-heme subunit/FixO Acid_3508 82 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 116622665 Common - amine oxidase Acid_3564 50 COG3349 COG3349, Uncharacterized conserved protein Function unknown 116624832 Common - serine/threonine protein kinase Acid_5756 134 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116622282 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_3176 11 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 116623136 Common - Ethyl tert-butyl ether degradation EthD Acid_4042 18 None None None 116625863 Nonpathogen - hypothetical protein Acid_6817 1 None None None 116625621 Common - protein of unknown function DUF214 Acid_6570 72 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116625725 Common - Radical SAM domain protein Acid_6674 77 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116621280 Nonpathogen - hypothetical protein Acid_2161 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116625866 Nonpathogen - putative PAS/PAC sensor protein Acid_6820 18 COG2202 AtoS, FOG: PAS/PAC domain Signal transduction mechanisms 116622809 Common - Oligopeptidase B Acid_3709 102 COG1770 PtrB, Protease II Amino acid transport and metabolism 116623567 Common - short-chain dehydrogenase/reductase SDR Acid_4477 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116622869 Common - hypothetical protein Acid_3770 8 None None None 116621793 Common - hypothetical protein Acid_2675 3 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 116625923 Common - hypothetical protein Acid_6880 34 None None None 116621078 Nonpathogen - hypothetical protein Acid_1959 1 None None None 116626364 Common - thiamine pyrophosphate enzyme domain protein TPP-binding Acid_7324 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 116621247 Nonpathogen - hypothetical protein Acid_2128 1 None None None 116626158 Nonpathogen - hypothetical protein Acid_7118 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116624589 Common - dihydroorotase, multifunctional complex type Acid_5513 212 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 116625988 Common - DegT/DnrJ/EryC1/StrS aminotransferase Acid_6946 191 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 116625961 Common - PHP C-terminal domain protein Acid_6919 73 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 116620742 Common - Integrase, catalytic region Acid_1623 11 None None None 116624500 Common - Multidrug resistance efflux pump-like protein Acid_5424 127 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116624898 Common - beta-lactamase Acid_5823 134 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116621393 Common - transposase IS3/IS911 family protein Acid_2274 51 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 116626231 Common - transport-associated Acid_7191 16 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 116620790 Nonpathogen - hypothetical protein Acid_1671 1 None None None 116620551 Nonpathogen - hypothetical protein Acid_1429 1 None None None 116623646 Common - 40-residue YVTN family beta-propeller repeat protein Acid_4558 61 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116623716 Common - multi-sensor hybrid histidine kinase Acid_4628 226 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116623254 Common - SAF domain Acid_4161 65 COG3745 CpaB, Flp pilus assembly protein CpaB Intracellular trafficking and secretion 116624996 Common - putative oxygen-independent coproporphyrinogen III oxidase Acid_5926 204 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 116626119 Nonpathogen - band 7 protein Acid_7077 4 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 116620872 Nonpathogen - hypothetical protein Acid_1753 1 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 116623367 Common - Methyltransferase type 11 Acid_4276 165 COG2519 GCD14, tRNA(1-methyladenosine) methyltransferase and related methyltransferases Translation, ribosomal structure and biogenesis 116626377 Common - peptidase S9, prolyl oligopeptidase active site domain protein Acid_7337 110 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116624904 Common - transposase IS116/IS110/IS902 family protein Acid_5830 87 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116624775 Common - electron transfer flavoprotein, alpha subunit Acid_5699 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 116619878 Common - short-chain dehydrogenase/reductase SDR Acid_0750 238 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 116620886 Nonpathogen - hypothetical protein Acid_1767 1 None None None 116621765 Common - glycosyl hydrolase, BNR repeat Acid_2647 43 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116626068 Common - hypothetical protein Acid_7026 9 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116620641 Common - hypothetical protein Acid_1520 48 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 116619212 Common - glutamine synthetase, type I Acid_0067 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 116619807 Nonpathogen - hypothetical protein Acid_0677 1 None None None 116625096 Nonpathogen - hypothetical protein Acid_6032 4 None None None 116624721 Common - pyruvate carboxylase Acid_5645 241 COG1038 PycA, Pyruvate carboxylase Energy production and conversion 116626571 Nonpathogen - hypothetical protein Acid_7534 1 None None None 116619932 Common - xylulokinase Acid_0804 183 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 116622294 Common - PP-loop domain protein Acid_3188 156 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 116626059 Common - Glycine hydroxymethyltransferase Acid_7017 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 116624249 Common - flavin reductase domain protein, FMN-binding Acid_5167 128 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 116626328 Common - Undecaprenyl-phosphate galactose phosphotransferase Acid_7288 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 116626103 Common - oxidoreductase domain protein Acid_7061 67 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116621189 Common - Sucrose phosphorylase Acid_2070 95 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 116621983 Common - OmpA/MotB domain protein Acid_2868 152 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 116621295 Nonpathogen - hypothetical protein Acid_2176 2 COG2318 DinB, Uncharacterized protein conserved in bacteria Function unknown 116620073 Nonpathogen - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_0945 2 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116623889 Nonpathogen - hypothetical protein Acid_4801 3 None None None 116624789 Common - Pyrrolo-quinoline quinone Acid_5713 70 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116626072 Common - Homoserine dehydrogenase Acid_7030 210 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 116626337 Common - UvrB/UvrC protein Acid_7297 199 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 116620241 Common - Redoxin domain protein Acid_1118 66 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116620848 Common - hypothetical protein Acid_1729 200 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 116624327 Common - protein of unknown function DUF214 Acid_5245 20 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116619424 Common - DegT/DnrJ/EryC1/StrS aminotransferase Acid_0283 196 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 116621184 Common - Xylose isomerase domain protein TIM barrel Acid_2065 5 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116620896 Common - MscS Mechanosensitive ion channel Acid_1777 170 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 116624127 Common - phosphoribosylaminoimidazole carboxylase, ATPase subunit Acid_5043 193 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 116619541 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_0400 163 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 116621365 Common - N-acylneuraminate-9-phosphate synthase Acid_2246 78 COG2089 SpsE, Sialic acid synthase Cell envelope biogenesis, outer membrane 116622725 Nonpathogen - hypothetical protein Acid_3624 1 None None None 116624361 Common - conserved repeat domain Acid_5282 10 None None None 116622510 Common - efflux transporter, RND family, MFP subunit Acid_3408 165 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 116621109 Common - Cna B-type protein Acid_1990 24 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116620386 Common - Alcohol dehydrogenase GroES domain protein Acid_1263 205 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 116622448 Common - Mannonate dehydratase Acid_3346 58 COG1312 UxuA, D-mannonate dehydratase Carbohydrate transport and metabolism 116619633 Common - hypothetical protein Acid_0494 23 None None None 116625284 Common - glycosyl transferase, group 1 Acid_6229 166 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116626862 Nonpathogen - hypothetical protein Acid_7837 1 None None None 116621095 Common - alpha/beta hydrolase fold Acid_1976 182 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 116626423 Common - hypothetical protein Acid_7385 9 None None None 116625824 Common - Cna B domain protein Acid_6775 22 None None None 116622034 Nonpathogen - hypothetical protein Acid_2919 1 None None None 116625381 Common - ribosomal protein L11 Acid_6326 246 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 116619621 Common - glycine dehydrogenase subunit 1 Acid_0482 173 COG0403 GcvP, Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain Amino acid transport and metabolism 116620200 Common - glutamyl-tRNA(Gln) amidotransferase, A subunit Acid_1073 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 116625564 Common - peptidase M28 Acid_6511 44 COG2234 Iap, Predicted aminopeptidases General function prediction only 116620810 Nonpathogen - hypothetical protein Acid_1691 1 None None None 116622476 Common - nicotinamide nucleotide transhydrogenase, subunit alpha Acid_3374 117 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 116624731 Common - Amidohydrolase 3 Acid_5655 105 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 116621067 Common - Pyrrolo-quinoline quinone Acid_1948 59 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116622945 Common - protein of unknown function DUF218 Acid_3847 12 COG1434 COG1434, Uncharacterized conserved protein Function unknown 116625412 Common - response regulator receiver modulated GAF sensor protein Acid_6357 137 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116623892 Common - aromatic amino acid beta-eliminating lyase/threonine aldolase Acid_4804 80 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 116626402 Nonpathogen - hypothetical protein Acid_7364 4 COG3595 COG3595, Uncharacterized conserved protein Function unknown 116620522 Common - thiamine biosynthesis protein ThiC Acid_1400 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 116621118 Common - hypothetical protein Acid_1999 17 None None None 116623592 Nonpathogen - hypothetical protein Acid_4502 1 None None None 116622243 Nonpathogen - response regulator receiver protein Acid_3136 14 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116623210 Nonpathogen - hypothetical protein Acid_4117 1 None None None 116625055 Common - hypothetical protein Acid_5985 4 None None None 116619738 Common - ABC-2 type transporter Acid_0603 198 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116621747 Nonpathogen - hypothetical protein Acid_2629 4 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 116623313 Common - signal recognition particle-docking protein FtsY Acid_4221 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 116623599 Nonpathogen - hypothetical protein Acid_4509 1 None None None 116625066 Nonpathogen - hypothetical protein Acid_5996 1 None None None 116622452 Common - virulence associated protein C Acid_3350 43 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 116625615 Nonpathogen - hypothetical protein Acid_6564 1 None None None 116626876 Common - Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein Acid_7852 105 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116622397 Nonpathogen - hypothetical protein Acid_3291 1 None None None 116623898 Common - MaoC domain protein dehydratase Acid_4810 14 COG2030 MaoC, Acyl dehydratase Lipid metabolism 116620364 Common - sulfatase Acid_1241 94 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116619321 Common - ketol-acid reductoisomerase Acid_0178 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 116624802 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_5726 35 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 116623243 Common - hypothetical protein Acid_4150 42 None None None 116623107 Common - hypothetical protein Acid_4011 23 COG3503 COG3503, Predicted membrane protein Function unknown 116620087 Common - ATP-dependent DNA helicase, RecQ family Acid_0959 224 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 116623673 Common - glutamine amidotransferase class-I Acid_4585 176 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 116621875 Nonpathogen - hypothetical protein Acid_2758 2 None None None 116620984 Common - multi-sensor hybrid histidine kinase Acid_1865 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116626507 Common - Heparinase II/III family protein Acid_7470 31 None None None 116623193 Common - protein of unknown function DUF583 Acid_4100 23 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 116619617 Common - peptidase S10, serine carboxypeptidase Acid_0478 38 COG2939 COG2939, Carboxypeptidase C (cathepsin A) Amino acid transport and metabolism 116619259 Common - respiratory-chain NADH dehydrogenase, subunit 1 Acid_0115 189 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 116623845 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Acid_4757 128 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 116622623 Nonpathogen - hypothetical protein Acid_3522 2 None None None 116623604 Common - peptide methionine sulfoxide reductase Acid_4514 205 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 116621670 Common - membrane protein-like protein Acid_2552 5 COG4872 COG4872, Predicted membrane protein Function unknown 116625765 Nonpathogen - cobalt transport protein Acid_6715 6 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 116624398 Nonpathogen - hypothetical protein Acid_5319 1 None None None 116620486 Common - acyl-protein synthetase, LuxE Acid_1364 21 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116620507 Common - transcriptional regulator, MarR family Acid_1385 47 COG1846 MarR, Transcriptional regulators Transcription 116622900 Nonpathogen - hypothetical protein Acid_3801 1 None None None 116620455 Common - aldehyde dehydrogenase Acid_1333 122 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 116625484 Common - phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Acid_6430 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 116620358 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_1235 139 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116620852 Common - TPR repeat-containing protein Acid_1733 12 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116621194 Common - hypothetical protein Acid_2075 15 None None None 116623095 Nonpathogen - protein of unknown function DUF1469 Acid_3999 1 None None None 116620943 Common - protein of unknown function DUF214 Acid_1824 148 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620039 Common - surface antigen variable number repeat protein Acid_0911 101 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 116626265 Common - Phosphoglycerate mutase Acid_7225 138 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 116620368 Common - amino acid permease-associated region Acid_1245 158 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116620449 Common - AMP-dependent synthetase and ligase Acid_1327 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116620152 Nonpathogen - major facilitator superfamily MFS_1 Acid_1025 1 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 116622819 Common - peptidase S41 Acid_3719 140 COG4946 COG4946, Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system Function unknown 116619261 Common - NADH-ubiquinone oxidoreductase, chain 4L Acid_0117 158 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 116620285 Common - RNA chaperone Hfq Acid_1162 127 COG1923 Hfq, Uncharacterized host factor I protein General function prediction only 116624848 Common - RNP-1 like RNA-binding protein Acid_5772 66 COG0724 COG0724, RNA-binding proteins (RRM domain) General function prediction only 116621994 Common - NHL repeat containing protein Acid_2879 12 COG4386 COG4386, Mu-like prophage tail sheath protein gpL General function prediction only 116622585 Common - Tetratricopeptide TPR_2 repeat protein Acid_3483 61 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116625143 Common - periplasmic ligand-binding sensor domain-like protein Acid_6081 15 COG3292 COG3292, Predicted periplasmic ligand-binding sensor domain Signal transduction mechanisms 116622804 Nonpathogen - hypothetical protein Acid_3704 1 None None None 116626499 Common - export protein FliQ, family 3 Acid_7462 56 COG1987 FliQ, Flagellar biosynthesis pathway, component FliQ Cell motility and secretion / Intracellular trafficking and secretion 116623867 Nonpathogen - hypothetical protein Acid_4779 1 None None None 116619548 Common - alpha-glucan phosphorylase Acid_0409 150 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 116620767 Common - lipopolysaccharide biosynthesis Acid_1648 36 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 116621166 Common - multi-sensor signal transduction histidine kinase Acid_2047 223 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 116626915 Common - protein of unknown function DUF58 Acid_7892 45 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 116626564 Common - glycoside hydrolase family 2, sugar binding Acid_7527 57 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 116623546 Nonpathogen - hypothetical protein Acid_4456 1 None None None 116624810 Nonpathogen - hypothetical protein Acid_5734 1 None None None 116626012 Common - proline iminopeptidase Acid_6970 118 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 116623798 Common - transcription elongation factor GreB Acid_4710 191 COG0782 GreA, Transcription elongation factor Transcription 116625223 Common - hypothetical protein Acid_6168 5 None None None 116619893 Nonpathogen - hypothetical protein Acid_0765 2 None None None 116623666 Common - protein of unknown function DUF214 Acid_4578 153 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116624914 Common - tryptophanyl-tRNA synthetase Acid_5840 228 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116624034 Nonpathogen - hypothetical protein Acid_4948 3 None None None 116620004 Common - LOC465997 Acid_0876 46 None None None 116626665 Nonpathogen - hypothetical protein Acid_7634 1 None None None 116625518 Common - hypothetical protein Acid_6465 24 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116619783 Common - hypothetical protein Acid_0653 5 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 116620149 Nonpathogen - hypothetical protein Acid_1022 1 None None None 116619584 Nonpathogen - hypothetical protein Acid_0445 1 None None None 116619612 Common - GCN5-related N-acetyltransferase Acid_0473 131 COG0456 RimI, Acetyltransferases General function prediction only 116623372 Common - L-carnitine dehydratase/bile acid-inducible protein F Acid_4281 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 116621323 Common - sugar-phosphate isomerases, RpiB/LacA/LacB family Acid_2204 128 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 116622561 Common - ABC transporter related Acid_3459 249 COG1124 DppF, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 116619703 Common - Carbamoyltransferase Acid_0568 52 COG2192 COG2192, Predicted carbamoyl transferase, NodU family Posttranslational modification, protein turnover, chaperones 116625107 Common - membrane bound O-acyl transferase, MBOAT family protein Acid_6043 85 COG1696 DltB, Predicted membrane protein involved in D-alanine export Cell envelope biogenesis, outer membrane 116622377 Common - Sel1 domain protein repeat-containing protein Acid_3271 104 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 116624221 Nonpathogen - hypothetical protein Acid_5137 1 None None None 116620166 Common - siroheme synthase Acid_1039 155 COG1648 CysG, Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) Coenzyme metabolism 116625408 Common - Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein Acid_6353 120 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116626500 Common - type III secretion system inner membrane R protein Acid_7463 92 COG1684 FliR, Flagellar biosynthesis pathway, component FliR Cell motility and secretion / Intracellular trafficking and secretion 116624940 Common - Ig family protein Acid_5867 22 None None None 116624612 Nonpathogen - RNA polymerase, alpha subunit domain protein Acid_5536 1 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 116624579 Nonpathogen - hypothetical protein Acid_5503 2 None None None 116621005 Nonpathogen - hypothetical protein Acid_1886 1 None None None 116621561 Nonpathogen - hypothetical protein Acid_2443 1 None None None 116624939 Common - Dihydroxy-acid dehydratase Acid_5866 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 116621379 Common - conserved hypothetical protein, putative NADH-dependent dyhydrogenase Acid_2260 4 None None None 116620633 Nonpathogen - hypothetical protein Acid_1512 1 COG5617 COG5617, Predicted integral membrane protein Function unknown 116625980 Common - hypothetical protein Acid_6938 22 COG5368 COG5368, Uncharacterized protein conserved in bacteria Function unknown 116619533 Common - integral membrane sensor signal transduction histidine kinase Acid_0392 222 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116621134 Common - Serine/threonine protein kinase-like protein Acid_2015 32 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116626965 Common - Integrase, catalytic region Acid_7942 151 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116620056 Nonpathogen - hypothetical protein Acid_0928 1 None None None 116624553 Common - two component transcriptional regulator, winged helix family Acid_5477 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116619901 Common - Haloacid dehalogenase domain protein hydrolase Acid_0773 23 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 116620756 Common - hypothetical protein Acid_1637 50 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 116624010 Common - peptidase S45, penicillin amidase Acid_4922 67 COG2366 COG2366, Protein related to penicillin acylase General function prediction only 116626186 Common - hypothetical protein Acid_7146 5 None None None 116624652 Common - peptidase M48, Ste24p Acid_5576 128 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116625569 Common - fumarylacetoacetase Acid_6516 66 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 116625878 Nonpathogen - hypothetical protein Acid_6832 1 None None None 116626384 Common - 3-dehydroquinate synthase Acid_7344 209 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 116620067 Nonpathogen - hypothetical protein Acid_0939 1 None None None 116623913 Common - glycoside hydrolase, family 16 Acid_4825 46 COG2273 SKN1, Beta-glucanase/Beta-glucan synthetase Carbohydrate transport and metabolism 116619221 Common - Osmosensitive K+ channel His kinase sensor domain Acid_0076 90 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 116625598 Common - protein of unknown function DUF1549 Acid_6547 8 COG3748 COG3748, Predicted membrane protein Function unknown 116626712 Common - hypothetical protein Acid_7684 13 None None None 116620304 Nonpathogen - hypothetical protein Acid_1181 1 None None None 116622592 Nonpathogen - hypothetical protein Acid_3490 2 None None None 116622789 Common - hypothetical protein Acid_3689 8 None None None 116621252 Nonpathogen - membrane-flanked domain Acid_2133 6 COG3428 COG3428, Predicted membrane protein Function unknown 116626938 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_7915 14 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116622138 Common - Polysulphide reductase, NrfD Acid_3026 8 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 116620082 Common - metallophosphoesterase Acid_0954 104 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 116622316 Common - hypothetical protein Acid_3210 4 COG0327 COG0327, Uncharacterized conserved protein Function unknown 116623053 Nonpathogen - putative squalene-hopene cyclase Acid_3957 2 None None None 116622188 Common - electron transfer flavoprotein beta-subunit Acid_3080 152 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 116624213 Nonpathogen - hypothetical protein Acid_5129 1 None None None 116622539 Common - Hemerythrin HHE cation binding domain protein Acid_3437 36 None None None 116626047 Common - Cna B-type protein Acid_7005 12 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116624766 Common - proton-translocating NADH-quinone oxidoreductase, chain N Acid_5690 210 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 116619717 Common - protein of unknown function DUF140 Acid_0582 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 116622937 Common - transcriptional regulator, PadR-like family Acid_3839 68 COG1695 COG1695, Predicted transcriptional regulators Transcription 116625532 Common - protein of unknown function DUF214 Acid_6479 107 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622214 Nonpathogen - hypothetical protein Acid_3106 1 None None None 116620178 Nonpathogen - transcriptional regulator, Fis family Acid_1051 1 None None None 116619889 Common - Uroporphyrinogen III synthase HEM4 Acid_0761 27 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 116625572 Common - protein of unknown function DUF1680 Acid_6519 29 COG3533 COG3533, Uncharacterized protein conserved in bacteria Function unknown 116620330 Common - carboxyl-terminal protease Acid_1207 182 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 116626452 Nonpathogen - hypothetical protein Acid_7414 6 None None None 116620470 Nonpathogen - conserved hypothetical protein, transmembrane prediction Acid_1348 6 None None None 116621059 Common - SMP-30/Gluconolaconase/LRE domain protein Acid_1940 23 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116619239 Common - acyl-CoA dehydrogenase domain protein Acid_0094 24 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 116622118 Common - short-chain dehydrogenase/reductase SDR Acid_3006 233 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 116625655 Common - PBS lyase HEAT domain protein repeat-containing protein Acid_6604 18 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 116619562 Nonpathogen - hypothetical protein Acid_0423 1 None None None 116622021 Common - response regulator receiver protein Acid_2906 124 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 116621020 Common - Glutamate--ammonia ligase Acid_1901 230 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 116620595 Nonpathogen - hypothetical protein Acid_1474 8 None None None 116621316 Common - Ankyrin Acid_2197 24 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 116620032 Common - uridylate kinase Acid_0904 239 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 116623922 Common - penicillin-binding protein, transpeptidase Acid_4834 171 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 116625431 Nonpathogen - hypothetical protein Acid_6376 1 None None None 116626216 Nonpathogen - hypothetical protein Acid_7176 1 None None None 116620016 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Acid_0888 59 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 116624635 Common - alpha-L-rhamnosidase Acid_5559 26 None None None 116620800 Common - hypothetical protein Acid_1681 42 None None None 116624307 Common - hypothetical protein Acid_5225 13 COG5649 COG5649, Uncharacterized conserved protein Function unknown 116619250 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Acid_0106 35 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 116624585 Common - TonB-dependent receptor Acid_5509 22 None None None 116624888 Common - PBS lyase HEAT domain protein repeat-containing protein Acid_5812 16 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 116622231 Common - hypothetical protein Acid_3124 5 None None None 116624493 Nonpathogen - hypothetical protein Acid_5415 1 None None None 116623734 Common - Acetyltransferase (isoleucine patch superfamily)-like protein Acid_4646 84 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 116625630 Common - proline racemase Acid_6579 47 COG3938 COG3938, Proline racemase Amino acid transport and metabolism 116625787 Common - hypothetical protein Acid_6737 3 None None None 116621335 Nonpathogen - hypothetical protein Acid_2216 1 None None None 116621224 Common - TRAP transporter solute receptor, TAXI family Acid_2105 55 COG2358 Imp, TRAP-type uncharacterized transport system, periplasmic component General function prediction only 116623508 Common - Cna B domain protein Acid_4418 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116619871 Common - beta-ketoacyl synthase Acid_0743 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116621119 Common - hypothetical protein Acid_2000 15 None None None 116624191 Common - ribosomal protein L24 Acid_5107 207 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 116626765 Nonpathogen - hypothetical protein Acid_7738 1 None None None 116620780 Common - D-3-phosphoglycerate dehydrogenase Acid_1661 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 116625129 Common - response regulator receiver protein Acid_6066 19 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116623326 Nonpathogen - hypothetical protein Acid_4235 2 None None None 116622540 Common - Ku domain protein Acid_3438 63 COG1273 COG1273, Uncharacterized conserved protein Function unknown 116625472 Common - peptidase M16 domain protein Acid_6418 137 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 116625951 Common - cytochrome c oxidase, subunit II Acid_6909 161 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 116625457 Nonpathogen - hypothetical protein Acid_6402 1 None None None 116619593 Common - eight transmembrane protein EpsH Acid_0454 34 None None None 116621953 Common - serine/threonine protein kinase Acid_2838 156 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116622957 Common - multi-sensor hybrid histidine kinase Acid_3859 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116625336 Common - YD repeat protein Acid_6281 71 COG3209 RhsA, Rhs family protein Cell envelope biogenesis, outer membrane 116622481 Common - anthranilate phosphoribosyltransferase Acid_3379 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 116622572 Common - protein of unknown function DUF214 Acid_3470 72 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116625600 Common - Nucleotidyl transferase Acid_6549 200 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 116625608 Common - putative nitrogen fixation protein Acid_6557 5 None None None 116626709 Nonpathogen - hypothetical protein Acid_7681 2 None None None 116620048 Nonpathogen - hypothetical protein Acid_0920 1 None None None 116623760 Common - protein of unknown function DUF218 Acid_4672 10 COG1434 COG1434, Uncharacterized conserved protein Function unknown 116619164 Nonpathogen - hypothetical protein Acid_0019 1 None None None 116620622 Common - lipoyl synthase Acid_1501 190 COG0320 LipA, Lipoate synthase Coenzyme metabolism 116622798 Nonpathogen - hypothetical protein Acid_3698 1 None None None 116626881 Nonpathogen - hypothetical protein Acid_7857 1 None None None 116623049 Common - protein of unknown function DUF1501 Acid_3953 5 COG4102 COG4102, Uncharacterized protein conserved in bacteria Function unknown 116622706 Nonpathogen - hypothetical protein Acid_3605 1 None None None 116621849 Nonpathogen - hypothetical protein Acid_2732 1 None None None 116622871 Nonpathogen - hypothetical protein Acid_3772 4 None None None 116622950 Common - Imidazoleglycerol-phosphate dehydratase Acid_3852 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 116620836 Common - phosphatidylserine decarboxylase related protein Acid_1717 91 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 116626700 Nonpathogen - hypothetical protein Acid_7672 2 None None None 116619732 Nonpathogen - hypothetical protein Acid_0597 1 None None None 116622062 Common - IstB domain protein ATP-binding protein Acid_2949 98 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 116623729 Common - ABC transporter related Acid_4641 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116624711 Nonpathogen - hypothetical protein Acid_5635 1 None None None 116624809 Common - Redoxin domain protein Acid_5733 75 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116620097 Common - transcriptional regulator, Fis family Acid_0970 14 None None None 116622134 Common - TPR repeat protein Acid_3022 32 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 116620233 Common - multi-sensor hybrid histidine kinase Acid_1110 219 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116622759 Common - type I phosphodiesterase/nucleotide pyrophosphatase Acid_3658 5 COG3083 COG3083, Predicted hydrolase of alkaline phosphatase superfamily General function prediction only 116622351 Common - Xylose isomerase domain protein TIM barrel Acid_3245 28 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116622533 Common - protein of unknown function UPF0153 Acid_3431 14 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 116619754 Nonpathogen - hypothetical protein Acid_0620 1 None None None 116621125 Nonpathogen - hypothetical protein Acid_2006 1 None None None 116625808 Common - ribosomal protein L32 Acid_6759 55 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 116623239 Nonpathogen - hypothetical protein Acid_4146 1 None None None 116619415 Common - hypothetical protein Acid_0274 82 None None None 116622742 Common - putative esterase Acid_3641 6 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 116623415 Common - transcriptional repressor, CopY family Acid_4324 27 COG3682 COG3682, Predicted transcriptional regulator Transcription 116623765 Nonpathogen - hypothetical protein Acid_4677 2 None None None 116626197 Common - hydrolase, HAD-superfamily, subfamily IIIA Acid_7157 130 COG0241 HisB, Histidinol phosphatase and related phosphatases Amino acid transport and metabolism 116626545 Common - glycosyl hydrolase, BNR repeat-containing protein Acid_7508 17 None None None 116621971 Nonpathogen - hypothetical protein Acid_2856 1 None None None 116624216 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_5132 6 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 116619811 Nonpathogen - hypothetical protein Acid_0681 1 None None None 116621637 Nonpathogen - hypothetical protein Acid_2519 3 None None None 116622646 Common - D-aminoacylase domain protein Acid_3545 69 COG3653 COG3653, N-acyl-D-aspartate/D-glutamate deacylase Secondary metabolites biosynthesis, transport, and catabolism 116622776 Common - L-seryl-tRNA(Sec) selenium transferase Acid_3675 72 COG1921 SelA, Selenocysteine synthase [seryl-tRNASer selenium transferase] Amino acid transport and metabolism 116624682 Common - bacteriophage N4 receptor, outer membrane protein Acid_5606 25 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116626516 Common - Abortive infection protein Acid_7479 11 None None None 116625674 Common - Radical SAM domain protein Acid_6623 106 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116619687 Nonpathogen - hypothetical protein Acid_0552 3 None None None 116625945 Common - protein of unknown function DUF336 Acid_6903 87 COG3193 GlcG, Uncharacterized protein, possibly involved in utilization of glycolate and propanediol General function prediction only 116621686 Common - hypothetical protein Acid_2568 8 None None None 116620140 Common - recA protein Acid_1013 228 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 116620267 Common - NHL repeat containing protein Acid_1144 34 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116619551 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Acid_0412 219 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116624418 Nonpathogen - hypothetical protein Acid_5340 1 None None None 116620173 Common - HpcH/HpaI aldolase Acid_1046 74 COG3836 HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase Carbohydrate transport and metabolism 116619880 Common - putative signal-transduction protein with CBS domains Acid_0752 158 COG0517 COG0517, FOG: CBS domain General function prediction only 116622161 Common - transcriptional regulator, PadR-like family Acid_3053 45 COG1695 COG1695, Predicted transcriptional regulators Transcription 116626616 Common - major facilitator superfamily MFS_1 Acid_7579 13 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 116622671 Common - GtrA family protein Acid_3570 11 COG2246 COG2246, Predicted membrane protein Function unknown 116621964 Nonpathogen - hypothetical protein Acid_2849 2 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116619438 Nonpathogen - hypothetical protein Acid_0297 1 None None None 116624477 Nonpathogen - hypothetical protein Acid_5399 5 None None None 116625186 Common - Methyltransferase type 11 Acid_6131 63 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116626051 Common - hypothetical protein Acid_7009 16 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116621760 Common - hypothetical protein Acid_2642 8 COG3678 CpxP, P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism 116626255 Common - peptidase M20 Acid_7215 165 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116620954 Common - amino acid permease-associated region Acid_1835 170 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116625274 Common - von Willebrand factor, type A Acid_6219 26 COG2425 COG2425, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 116619994 Common - urea amidolyase related protein Acid_0866 233 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 116620415 Nonpathogen - hypothetical protein Acid_1292 1 None None None 116622085 Common - hypothetical protein Acid_2972 8 None None None 116626249 Common - transcriptional regulator, PadR-like family Acid_7209 40 COG1695 COG1695, Predicted transcriptional regulators Transcription 116623213 Nonpathogen - hypothetical protein Acid_4120 1 None None None 116626343 Common - glucosamine--fructose-6-phosphate aminotransferase, isomerizing Acid_7303 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 116624410 Nonpathogen - hypothetical protein Acid_5332 2 COG4099 COG4099, Predicted peptidase General function prediction only 116625539 Common - efflux transporter, RND family, MFP subunit Acid_6486 163 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 116622687 Nonpathogen - cell surface glycoprotein (s-layer protein) related protein-like protein Acid_3586 20 None None None 116625350 Nonpathogen - hypothetical protein Acid_6295 1 None None None 116626806 Common - type II secretion system protein Acid_7779 141 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 116623996 Common - oxidoreductase domain protein Acid_4908 180 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116620604 Common - thiamine pyrophosphate enzyme domain protein TPP-binding Acid_1483 221 COG3962 COG3962, Acetolactate synthase Amino acid transport and metabolism 116622387 Common - HpcH/HpaI aldolase Acid_3281 74 COG3836 HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase Carbohydrate transport and metabolism 116623232 Nonpathogen - hypothetical protein Acid_4139 1 None None None 116619655 Nonpathogen - hypothetical protein Acid_0516 1 None None None 116619341 Common - glycoside hydrolase, family 9 Acid_0198 17 None None None 116624496 Common - Patatin Acid_5420 127 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 116619395 Common - major facilitator superfamily MFS_1 Acid_0254 180 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116625635 Common - protein of unknown function, zinc metallopeptidase putative Acid_6584 85 COG2321 COG2321, Predicted metalloprotease General function prediction only 116622566 Common - glycoside hydrolase, family 29 (alpha-L-fucosidase) Acid_3464 32 COG3669 COG3669, Alpha-L-fucosidase Carbohydrate transport and metabolism 116619645 Common - PilT protein domain protein Acid_0506 27 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 116620826 Common - Tetratricopeptide TPR_2 repeat protein Acid_1707 25 COG0457 NrfG, FOG: TPR repeat General function prediction only 116620339 Common - Tetratricopeptide TPR_2 repeat protein Acid_1216 156 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116623142 Nonpathogen - hypothetical protein Acid_4048 1 None None None 116620483 Common - acyl carrier protein Acid_1361 9 None None None 116626485 Common - flagellar protein FliS Acid_7448 90 COG1516 FliS, Flagellin-specific chaperone FliS Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 116625772 Common - phosphoribosylformylglycinamidine cyclo-ligase Acid_6722 226 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 116622636 Nonpathogen - hypothetical protein Acid_3535 1 None None None 116621270 Common - LmbE family protein Acid_2151 18 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 116619171 Common - bifunctional deaminase-reductase domain protein Acid_0026 72 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 116626032 Common - pyruvate ferredoxin/flavodoxin oxidoreductase Acid_6990 61 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 116624470 Nonpathogen - hypothetical protein Acid_5392 2 None None None 116624437 Common - peptidase M28 Acid_5359 42 COG2234 Iap, Predicted aminopeptidases General function prediction only 116625045 Common - peptidase S9, prolyl oligopeptidase active site domain protein Acid_5975 126 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116622076 Common - OmpA/MotB domain protein Acid_2963 166 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 116620674 Common - Haloacid dehalogenase domain protein hydrolase Acid_1554 23 COG0546 Gph, Predicted phosphatases General function prediction only 116620104 Common - putative heat-shock chaperone protein Acid_0977 230 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 116624892 Common - Oligopeptidase A Acid_5816 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 116621988 Common - putative alpha-1,2-mannosidase Acid_2873 26 COG3537 COG3537, Putative alpha-1,2-mannosidase Carbohydrate transport and metabolism 116620816 Common - hypothetical protein Acid_1697 3 None None None 116624937 Nonpathogen - Xylose isomerase domain protein TIM barrel Acid_5864 5 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116625425 Common - hypothetical protein Acid_6370 3 None None None 116626558 Common - penicillin-binding protein, transpeptidase Acid_7521 197 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 116621128 Common - TonB-dependent receptor Acid_2009 26 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116626628 Common - Tetratricopeptide TPR_2 repeat protein Acid_7591 34 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116624319 Common - peptidase M50 Acid_5237 16 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 116621444 Nonpathogen - hypothetical protein Acid_2326 4 None None None 116620040 Common - dihydrolipoamide dehydrogenase Acid_0912 246 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 116623813 Common - selenide, water dikinase Acid_4725 156 COG0709 SelD, Selenophosphate synthase Amino acid transport and metabolism 116622891 Nonpathogen - hypothetical protein Acid_3792 1 None None None 116625114 Nonpathogen - hypothetical protein Acid_6050 1 None None None 116623077 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Acid_3981 58 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116623936 Common - beta-lactamase Acid_4848 152 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116622001 Nonpathogen - hypothetical protein Acid_2886 1 None None None 116625780 Common - exodeoxyribonuclease III Xth Acid_6730 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 116626168 Nonpathogen - type IV pilus assembly PilZ Acid_7128 1 None None None 116619338 Common - transcriptional regulator, GntR family Acid_0195 130 COG1802 GntR, Transcriptional regulators Transcription 116624280 Nonpathogen - hypothetical protein Acid_5198 1 None None None 116625318 Common - serine/threonine protein kinase Acid_6263 145 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116623537 Common - peptidase C26 Acid_4447 123 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 116624689 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Acid_5613 27 COG4934 COG4934, Predicted protease Posttranslational modification, protein turnover, chaperones 116623745 Common - Ig domain protein, group 2 domain protein Acid_4657 19 None None None 116624239 Nonpathogen - hypothetical protein Acid_5156 3 None None None 116624700 Common - Mn2+/Fe2+ transporter, NRAMP family Acid_5624 173 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 116623042 Nonpathogen - hypothetical protein Acid_3946 1 None None None 116625958 Common - hypothetical protein Acid_6916 4 None None None 116622166 Common - hypothetical protein Acid_3058 4 None None None 116622530 Common - Urea carboxylase Acid_3428 50 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 116626921 Common - protein of unknown function DUF1130 Acid_7898 58 COG5483 COG5483, Uncharacterized conserved protein Function unknown 116620260 Common - response regulator receiver protein Acid_1137 205 COG4963 CpaE, Flp pilus assembly protein, ATPase CpaE Intracellular trafficking and secretion 116620722 Common - AAA ATPase, central domain protein Acid_1602 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 116625520 Common - GMP synthase, small subunit Acid_6467 238 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 116623566 Common - protein of unknown function DUF1486 Acid_4476 13 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 116620582 Common - response regulator receiver protein Acid_1461 198 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 116626233 Common - peptidase M28 Acid_7193 42 COG2234 Iap, Predicted aminopeptidases General function prediction only 116621822 Common - major facilitator superfamily MFS_1 Acid_2704 176 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116625749 Common - Rieske (2Fe-2S) domain protein Acid_6699 69 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 116620711 Common - hypothetical protein Acid_1591 23 None None None 116623373 Common - protein of unknown function DUF1486 Acid_4282 30 COG5485 COG5485, Predicted ester cyclase General function prediction only 116623017 Common - alpha/beta hydrolase fold Acid_3921 49 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 116625311 Common - hypothetical protein Acid_6256 65 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116625496 Common - excinuclease ABC, A subunit Acid_6443 231 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 116619529 Nonpathogen - protein of unknown function DUF362 Acid_0388 19 COG2006 COG2006, Uncharacterized conserved protein Function unknown 116626678 Nonpathogen - hypothetical protein Acid_7648 11 COG1874 LacA, Beta-galactosidase Carbohydrate transport and metabolism 116622236 Common - hypothetical protein Acid_3129 3 COG3016 PhuW, Uncharacterized iron-regulated protein Function unknown 116624147 Common - DinB family protein Acid_5063 6 COG2318 DinB, Uncharacterized protein conserved in bacteria Function unknown 116621159 Common - histidine kinase Acid_2040 189 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 116626742 Common - GTP-binding protein Era Acid_7714 231 COG1159 Era, GTPase General function prediction only 116619179 Common - hypothetical protein Acid_0034 21 None None None 116623015 Common - protein of unknown function DUF214 Acid_3919 136 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623197 Common - hypothetical protein Acid_4104 71 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116626673 Common - phage integrase family protein Acid_7642 39 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116626693 Common - protein of unknown function DUF1549 Acid_7665 5 None None None 116620850 Nonpathogen - hypothetical protein Acid_1731 1 None None None 116621813 Common - transcriptional repressor, CopY family Acid_2695 21 COG3682 COG3682, Predicted transcriptional regulator Transcription 116623970 Nonpathogen - O-antigen polymerase Acid_4882 4 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 116624075 Nonpathogen - transcriptional regulator, XRE family Acid_4989 1 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 116623692 Common - hypothetical protein Acid_4604 21 None None None 116624539 Common - hypothetical protein Acid_5463 4 None None None 116625291 Common - peptidase S10, serine carboxypeptidase Acid_6236 37 COG2939 COG2939, Carboxypeptidase C (cathepsin A) Amino acid transport and metabolism 116625307 Common - protein of unknown function DUF214 Acid_6252 106 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116625505 Nonpathogen - hypothetical protein Acid_6452 1 None None None 116621275 Common - short-chain dehydrogenase/reductase SDR Acid_2156 218 COG0623 FabI, Enoyl- acyl-carrier-protein 116622554 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Acid_3452 124 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 116622851 Common - transcriptional regulator, GntR family Acid_3751 127 COG1725 COG1725, Predicted transcriptional regulators Transcription 116624391 Common - zinc finger, CDGSH-type domain protein Acid_5312 22 COG3369 COG3369, Uncharacterized conserved protein Function unknown 116620933 Nonpathogen - hypothetical protein Acid_1814 2 None None None 116622056 Common - transposase IS66 Acid_2942 10 None None None 116625329 Common - hypothetical protein Acid_6274 5 None None None 116621956 Common - transcriptional regulator of molybdate metabolism, XRE family Acid_2841 87 COG1910 COG1910, Periplasmic molybdate-binding protein/domain Inorganic ion transport and metabolism 116622513 Common - hypothetical protein Acid_3411 10 None None None 116625267 Common - Redoxin domain protein Acid_6212 161 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116622322 Common - hypothetical protein Acid_3216 35 COG4117 COG4117, Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) Energy production and conversion 116623810 Common - peptidase M24 Acid_4722 218 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 116619834 Nonpathogen - hypothetical protein Acid_0704 2 None None None 116619727 Common - thioredoxin reductase Acid_0592 246 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 116621458 Common - glycosyl transferase, family 2 Acid_2340 140 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116623451 Common - Methyltransferase type 12 Acid_4360 60 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116626588 Common - protein of unknown function DUF214 Acid_7551 40 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116619616 Common - hypothetical protein Acid_0477 72 COG2924 COG2924, Uncharacterized protein conserved in bacteria Function unknown 116621744 Common - hypothetical protein Acid_2626 21 None None None 116623457 Nonpathogen - transcriptional regulator, AbrB family Acid_4366 1 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 116623805 Common - Chorismate mutase Acid_4717 54 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 116622785 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Acid_3685 234 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 116624971 Common - Peroxidase Acid_5901 209 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116621895 Common - cytochrome P450 Acid_2780 74 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 116625321 Common - hypothetical protein Acid_6266 5 None None None 116622046 Common - transcriptional regulator, Crp/Fnr family Acid_2932 168 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 116622767 Nonpathogen - hypothetical protein Acid_3666 4 COG3503 COG3503, Predicted membrane protein Function unknown 116619353 Common - hypothetical protein Acid_0211 6 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116621856 Nonpathogen - hypothetical protein Acid_2739 1 None None None 116619953 Common - hypothetical protein Acid_0825 14 None None None 116626034 Common - RNA binding S1 domain protein Acid_6992 214 COG2183 Tex, Transcriptional accessory protein Transcription 116623530 Nonpathogen - hypothetical protein Acid_4440 3 COG2267 PldB, Lysophospholipase Lipid metabolism 116624366 Nonpathogen - hypothetical protein Acid_5287 1 None None None 116624833 Nonpathogen - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_5757 2 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116624825 Common - serine/threonine protein kinase Acid_5749 193 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116626762 Common - Radical SAM domain protein Acid_7735 81 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116623753 Nonpathogen - hypothetical protein Acid_4665 1 None None None 116620443 Nonpathogen - hypothetical protein Acid_1321 1 None None None 116625157 Common - hypothetical protein Acid_6097 4 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 116626477 Common - glycosyl transferase, family 2 Acid_7440 91 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 116620560 Common - glycosyl transferase, family 39 Acid_1438 69 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116625373 Common - heat shock protein DnaJ domain protein Acid_6318 33 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 116625626 Nonpathogen - hypothetical protein Acid_6575 1 None None None 116621325 Common - serine phosphatase Acid_2206 151 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 116625344 Common - protein of unknown function DUF1501 Acid_6289 5 None None None 116622353 Nonpathogen - hypothetical protein Acid_3247 4 None None None 116621879 Common - hypothetical protein Acid_2762 12 None None None 116624675 Common - Alcohol dehydrogenase, zinc-binding domain protein Acid_5599 151 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 116619497 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Acid_0356 109 COG4631 XdhB, Xanthine dehydrogenase, molybdopterin-binding subunit B Nucleotide transport and metabolism 116621473 Common - ABC transporter related Acid_2355 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 116623104 Common - hypothetical protein Acid_4008 24 COG3826 COG3826, Uncharacterized protein conserved in bacteria Function unknown 116621421 Common - AAA ATPase, central domain protein Acid_2303 249 COG1222 RPT1, ATP-dependent 26S proteasome regulatory subunit Posttranslational modification, protein turnover, chaperones 116624377 Common - DoxX family protein Acid_5298 22 None None None 116620925 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Acid_1806 2 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 116624829 Common - TonB-dependent receptor Acid_5753 26 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116619742 Common - protein of unknown function DUF1025 Acid_0607 32 COG3824 COG3824, Uncharacterized protein conserved in bacteria Function unknown 116622577 Nonpathogen - hypothetical protein Acid_3475 1 None None None 116619191 Nonpathogen - hypothetical protein Acid_0046 4 COG4972 PilM, Tfp pilus assembly protein, ATPase PilM Cell motility and secretion / Intracellular trafficking and secretion 116624724 Common - hypothetical protein Acid_5648 2 None None None 116625348 Common - hypothetical protein Acid_6293 32 COG1846 MarR, Transcriptional regulators Transcription 116623637 Common - hypothetical protein Acid_4549 9 None None None 116625522 Common - outer membrane chaperone Skp (OmpH) Acid_6469 53 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 116621428 Common - signal transduction histidine kinase, LytS Acid_2310 102 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 116619479 Common - flagellar basal-body rod protein FlgC Acid_0338 122 COG1558 FlgC, Flagellar basal body rod protein Cell motility and secretion 116623009 Common - hypothetical protein Acid_3913 10 None None None 116621809 Common - oxidoreductase domain protein Acid_2691 173 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116624458 Nonpathogen - hypothetical protein Acid_5380 3 None None None 116626864 Common - two component, sigma54 specific, transcriptional regulator, Fis family Acid_7839 223 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116619505 Common - amidase, hydantoinase/carbamoylase family Acid_0364 84 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116620518 Nonpathogen - hypothetical protein Acid_1396 1 None None None 116620921 Common - glycosyl transferase, family 2 Acid_1802 193 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116622258 Nonpathogen - hypothetical protein Acid_3152 2 None None None 116624110 Nonpathogen - hypothetical protein Acid_5025 7 None None None 116619597 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_0458 173 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116626117 Common - tRNA(Ile)-lysidine synthetase Acid_7075 210 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 116622416 Common - phage integrase family protein Acid_3312 217 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116621374 Common - amidohydrolase 2 Acid_2255 43 COG3618 COG3618, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 116626775 Common - response regulator receiver protein Acid_7748 155 COG4963 CpaE, Flp pilus assembly protein, ATPase CpaE Intracellular trafficking and secretion 116621603 Nonpathogen - hypothetical protein Acid_2485 1 None None None 116626448 Nonpathogen - hypothetical protein Acid_7410 2 None None None 116620701 Common - efflux transporter, RND family, MFP subunit Acid_1581 163 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 116625826 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Acid_6777 81 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116623831 Nonpathogen - hypothetical protein Acid_4743 2 None None None 116625064 Common - phage integrase family protein Acid_5994 160 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116624702 Nonpathogen - peptidase M10A and M12B, matrixin and adamalysin Acid_5626 2 None None None 116622793 Common - serine/threonine protein kinase Acid_3693 202 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116620505 Common - short-chain dehydrogenase/reductase SDR Acid_1383 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116626108 Common - oxidoreductase domain protein Acid_7066 174 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116619372 Common - Methyltransferase type 12 Acid_0230 38 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 116625799 Common - PAS/PAC sensor hybrid histidine kinase Acid_6749 225 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116625041 Nonpathogen - hypothetical protein Acid_5971 1 None None None 116619249 Common - TonB-dependent receptor, plug Acid_0105 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116621554 Nonpathogen - hypothetical protein Acid_2436 2 None None None 116621580 Nonpathogen - hypothetical protein Acid_2462 5 None None None 116623644 Nonpathogen - hypothetical protein Acid_4556 2 None None None 116623030 Common - putative esterase Acid_3934 29 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 116624421 Common - hypothetical protein Acid_5343 37 COG4430 COG4430, Uncharacterized protein conserved in bacteria Function unknown 116624602 Common - Radical SAM domain protein Acid_5526 99 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116626042 Nonpathogen - hypothetical protein Acid_7000 1 None None None 116626687 Common - dihydropyrimidinase Acid_7659 206 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 116624934 Common - transcriptional regulator, TraR/DksA family Acid_5861 128 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 116622109 Common - cyclase/dehydrase Acid_2996 34 COG5637 COG5637, Predicted integral membrane protein Function unknown 116622329 Nonpathogen - hypothetical protein Acid_3223 1 None None None 116622302 Nonpathogen - protein of unknown function UPF0150 Acid_3196 3 COG1598 COG1598, Uncharacterized conserved protein Function unknown 116624922 Nonpathogen - hypothetical protein Acid_5848 2 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 116619230 Common - ABC transporter related Acid_0085 248 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 116623025 Common - gamma-glutamyltransferase Acid_3929 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 116622111 Common - putative aminoacid/polyamine transporter, permease protein Acid_2999 43 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116626548 Nonpathogen - hypothetical protein Acid_7511 1 None None None 116623038 Nonpathogen - hypothetical protein Acid_3942 1 None None None 116622156 Common - Carboxylesterase, type B Acid_3048 71 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 116624879 Common - hypothetical protein Acid_5803 19 None None None 116623738 Common - hypothetical protein Acid_4650 8 None None None 116620197 Nonpathogen - ROK family protein Acid_1070 3 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 116621598 Nonpathogen - hypothetical protein Acid_2480 1 None None None 116619750 Common - Methyltransferase type 12 Acid_0616 16 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116624491 Common - Pyrrolo-quinoline quinone Acid_5413 62 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116620434 Nonpathogen - hypothetical protein Acid_1312 3 None None None 116620542 Common - putative adenylate/guanylate cyclase Acid_1420 77 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 116623306 Nonpathogen - hypothetical protein Acid_4213 2 None None None 116619574 Common - FAD linked oxidase domain protein Acid_0435 75 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 116622124 Common - Radical SAM domain protein Acid_3012 71 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116626279 Common - translation initiation factor IF-1 Acid_7239 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 116620536 Common - type II secretion system protein Acid_1414 69 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion 116621103 Common - glycosyl transferase, family 28 Acid_1984 37 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 116621430 Nonpathogen - hypothetical protein Acid_2312 2 None None None 116622875 Common - Methyltransferase type 11 Acid_3776 161 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 116626812 Nonpathogen - Fimbrial assembly family protein Acid_7785 1 COG4972 PilM, Tfp pilus assembly protein, ATPase PilM Cell motility and secretion / Intracellular trafficking and secretion 116626461 Common - Rhodanese domain protein Acid_7424 116 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 116623031 Common - ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp Acid_3935 46 COG0439 AccC, Biotin carboxylase Lipid metabolism 116623320 Common - hypothetical protein Acid_4229 12 COG3918 COG3918, Predicted membrane protein Function unknown 116623627 Common - malic enzyme Acid_4539 212 COG0281 SfcA, Malic enzyme Energy production and conversion 116620376 Common - response regulator receiver protein Acid_1253 199 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 116621564 Common - dihydrodipicolinate synthetase Acid_2446 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 116622678 Common - DNA mismatch repair protein MutS domain protein Acid_3577 195 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 116622692 Common - cyclase family protein Acid_3591 89 COG1878 COG1878, Predicted metal-dependent hydrolase General function prediction only 116619859 Nonpathogen - hypothetical protein Acid_0731 1 None None None 116621038 Common - protein of unknown function DUF132 Acid_1919 15 COG1569 COG1569, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 116622384 Nonpathogen - hypothetical protein Acid_3278 8 None None None 116622045 Common - Fe-S protein, radical SAM family Acid_2931 115 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116624573 Common - Exoribonuclease II Acid_5497 191 COG0557 VacB, Exoribonuclease R Transcription 116623475 Nonpathogen - hypothetical protein Acid_4385 5 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 116621301 Common - GTP cyclohydrolase II Acid_2182 181 COG0807 RibA, GTP cyclohydrolase II Coenzyme metabolism 116623153 Common - protein of unknown function DUF1549 Acid_4059 6 None None None 116620802 Common - ATPase associated with various cellular activities, AAA_5 Acid_1683 21 COG0714 COG0714, MoxR-like ATPases General function prediction only 116622286 Common - transposase IS116/IS110/IS902 family protein Acid_3180 82 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116626093 Nonpathogen - hypothetical protein Acid_7051 1 None None None 116624117 Common - integral membrane sensor signal transduction histidine kinase Acid_5033 197 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116622442 Common - sulphate transporter Acid_3340 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 116626892 Common - deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase Acid_7869 65 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 116625013 Common - phosphoribosylformylglycinamidine synthase I Acid_5943 230 COG0047 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain Nucleotide transport and metabolism 116624435 Common - hypothetical protein Acid_5357 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 116624450 Common - response regulator receiver protein Acid_5372 217 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116621345 Common - Carbon-monoxide dehydrogenase (acceptor) Acid_2226 110 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 116622867 Nonpathogen - hypothetical protein Acid_3768 1 None None None 116626002 Common - carboxyl transferase Acid_6960 214 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 116626061 Common - Anticodon-binding domain protein Acid_7019 186 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116619984 Common - hypothetical protein Acid_0856 45 COG4257 Vgb, Streptogramin lyase Defense mechanisms 116620235 Common - catalase/peroxidase HPI Acid_1112 98 COG0376 KatG, Catalase (peroxidase I) Inorganic ion transport and metabolism 116626585 Common - oxidoreductase Acid_7548 92 COG1453 COG1453, Predicted oxidoreductases of the aldo/keto reductase family General function prediction only 116622208 Common - major facilitator superfamily MFS_1 Acid_3100 100 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116625752 Nonpathogen - hypothetical protein Acid_6702 2 None None None 116626653 Nonpathogen - hypothetical protein Acid_7622 1 None None None 116625871 Nonpathogen - R27-2 protein Acid_6825 1 None None None 116624466 Nonpathogen - Peptidoglycan-binding domain 1 protein Acid_5388 4 COG3409 COG3409, Putative peptidoglycan-binding domain-containing protein Cell envelope biogenesis, outer membrane 116626468 Common - signal transduction histidine kinase, nitrogen specific, NtrB Acid_7431 224 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 116620982 Common - PilT protein domain protein Acid_1863 50 COG4956 COG4956, Integral membrane protein (PIN domain superfamily) General function prediction only 116626154 Common - hypothetical protein Acid_7113 2 None None None 116625684 Common - HPr kinase Acid_6633 8 COG1493 HprK, Serine kinase of the HPr protein, regulates carbohydrate metabolism Signal transduction mechanisms 116625591 Common - protein of unknown function DUF1501 Acid_6540 5 COG4102 COG4102, Uncharacterized protein conserved in bacteria Function unknown 116622170 Common - multicopper oxidase, type 3 Acid_3062 124 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 116621977 Common - protein of unknown function DUF214 Acid_2862 171 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620880 Nonpathogen - protein of unknown function DUF52 Acid_1761 44 COG1355 COG1355, Predicted dioxygenase General function prediction only 116626814 Nonpathogen - hypothetical protein Acid_7787 1 None None None 116621639 Common - phage integrase family protein Acid_2521 132 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116620163 Nonpathogen - hypothetical protein Acid_1036 2 None None None 116623989 Common - glycoside hydrolase family 2, sugar binding Acid_4901 72 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 116625115 Nonpathogen - hypothetical protein Acid_6051 1 None None None 116619387 Common - protocatechuate 3,4-dioxygenase, alpha subunit Acid_0246 40 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 116623364 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_4273 37 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 116623485 Nonpathogen - hypothetical protein Acid_4395 1 None None None 116623778 Nonpathogen - hypothetical protein Acid_4690 1 None None None 116621645 Common - YD repeat protein Acid_2527 49 None None None 116621701 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_2583 23 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 116623343 Nonpathogen - phosphoesterase PHP domain protein Acid_4252 12 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 116626901 Common - two component transcriptional regulator, LuxR family Acid_7878 212 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116625033 Nonpathogen - hypothetical protein Acid_5963 3 None None None 116622519 Nonpathogen - hypothetical protein Acid_3417 1 None None None 116619695 Nonpathogen - hypothetical protein Acid_0560 2 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 116621854 Common - transcriptional regulator, IclR family Acid_2737 124 COG1414 IclR, Transcriptional regulator Transcription 116622642 Nonpathogen - hypothetical protein Acid_3541 9 None None None 116623217 Common - hypothetical protein Acid_4124 11 None None None 116624830 Common - glyoxalase Acid_5754 28 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 116622320 Common - translation elongation factor P Acid_3214 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 116623933 Common - Endoribonuclease L-PSP Acid_4845 91 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 116619719 Nonpathogen - conserved repeat domain Acid_0584 5 None None None 116621640 Common - phage integrase family protein Acid_2522 221 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116619311 Common - protein of unknown function DUF125, transmembrane Acid_0168 78 COG1814 COG1814, Uncharacterized membrane protein Function unknown 116619422 Nonpathogen - hypothetical protein Acid_0281 1 None None None 116625984 Common - glycosyl transferase, family 2 Acid_6942 181 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116621146 Common - ATP-dependent protease La Acid_2027 211 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 116624590 Nonpathogen - hypothetical protein Acid_5514 2 None None None 116620059 Nonpathogen - hypothetical protein Acid_0931 1 None None None 116621439 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_2321 161 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116622309 Nonpathogen - hypothetical protein Acid_3203 1 None None None 116624695 Common - GTP cyclohydrolase I Acid_5619 114 COG0780 COG0780, Enzyme related to GTP cyclohydrolase I General function prediction only 116625855 Nonpathogen - hypothetical protein Acid_6809 1 None None None 116623469 Common - electron transport protein SCO1/SenC Acid_4379 40 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 116623823 Nonpathogen - hypothetical protein Acid_4735 1 None None None 116620382 Common - hydroxymethylbutenyl pyrophosphate reductase Acid_1259 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 116620684 Common - 6-pyruvoyl tetrahydropterin synthase and hypothetical protein Acid_1564 23 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 116620427 Common - hypothetical protein Acid_1304 24 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116619347 Common - Cna B domain protein Acid_0205 24 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116619745 Nonpathogen - hypothetical protein Acid_0611 1 COG2605 COG2605, Predicted kinase related to galactokinase and mevalonate kinase General function prediction only 116624067 Nonpathogen - hypothetical protein Acid_4981 1 None None None 116625051 Common - protein of unknown function DUF214 Acid_5981 171 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116625444 Common - Lanthionine synthetase C family protein Acid_6389 15 COG4403 LcnDR2, Lantibiotic modifying enzyme Defense mechanisms 116625404 Nonpathogen - hypothetical protein Acid_6349 4 None None None 116621306 Common - diaminopimelate decarboxylase Acid_2187 217 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 116625761 Common - CDP-alcohol phosphatidyltransferase Acid_6711 95 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 116623379 Nonpathogen - hypothetical protein Acid_4288 1 COG3157 Hcp, Hemolysin-coregulated protein (uncharacterized) Function unknown 116624265 Common - ribosome-binding factor A Acid_5183 166 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 116624562 Common - 40-residue YVTN family beta-propeller repeat protein Acid_5486 39 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116620994 Nonpathogen - hypothetical protein Acid_1875 1 None None None 116624158 Common - ferrous iron transport protein B Acid_5074 218 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 116626371 Common - AAA ATPase Acid_7331 216 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 116620095 Common - fumarylacetoacetate (FAA) hydrolase Acid_0967 117 COG3970 COG3970, Fumarylacetoacetate (FAA) hydrolase family protein General function prediction only 116623550 Common - sulphate transporter Acid_4460 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 116623113 Common - TonB-dependent receptor, plug Acid_4018 29 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116620254 Common - response regulator receiver protein Acid_1131 220 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 116625433 Common - excinuclease ABC subunit B Acid_6378 224 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 116626791 Common - oxidoreductase domain protein Acid_7764 3 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116622224 Common - hypothetical protein Acid_3117 4 None None None 116623630 Nonpathogen - TadE family protein Acid_4542 1 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 116624953 Common - Cna B domain protein Acid_5882 14 COG4371 COG4371, Predicted membrane protein Function unknown 116622842 Common - alpha-L-rhamnosidase Acid_3742 18 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 116624024 Common - Penicillin amidase Acid_4936 76 COG2366 COG2366, Protein related to penicillin acylase General function prediction only 116621838 Common - peptidase M20 Acid_2720 145 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116625414 Common - CutA1 divalent ion tolerance protein Acid_6359 120 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 116626057 Nonpathogen - hypothetical protein Acid_7015 3 None None None 116623557 Common - Cellulase Acid_4467 92 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 116626008 Common - ABC-2 type transporter Acid_6966 82 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 116619846 Nonpathogen - hypothetical protein Acid_0718 1 None None None 116626175 Common - putative membrane-associated zinc metalloprotease Acid_7135 210 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 116625084 Common - TonB family protein Acid_6018 24 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 116620499 Common - polysaccharide biosynthesis protein Acid_1377 35 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 116626967 Common - protein of unknown function DUF214 Acid_7944 100 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622327 Common - protein of unknown function DUF214 Acid_3221 11 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623250 Nonpathogen - hypothetical protein Acid_4157 4 None None None 116619865 Common - protein of unknown function UPF0047 Acid_0737 95 COG0432 COG0432, Uncharacterized conserved protein Function unknown 116619379 Common - protein of unknown function DUF879 Acid_0237 48 COG3519 COG3519, Uncharacterized protein conserved in bacteria Function unknown 116621762 Common - peptidase M56, BlaR1 Acid_2644 21 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 116624718 Common - ApbE family lipoprotein Acid_5642 108 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 116625122 Common - Integrase, catalytic region Acid_6059 77 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 116621171 Common - transcriptional regulator, NifA subfamily, Fis Family Acid_2052 171 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 116626084 Nonpathogen - hypothetical protein Acid_7042 1 None None None 116622656 Nonpathogen - hypothetical protein Acid_3555 5 COG1915 COG1915, Uncharacterized conserved protein Function unknown 116623391 Common - histidine triad (HIT) protein Acid_4300 107 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 116625957 Common - protein of unknown function DUF892 Acid_6915 36 COG3685 COG3685, Uncharacterized protein conserved in bacteria Function unknown 116619638 Common - cytochrome c oxidase, subunit III Acid_0499 159 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 116622068 Nonpathogen - hypothetical protein Acid_2955 1 None None None 116619772 Nonpathogen - hypothetical protein Acid_0642 1 None None None 116623959 Nonpathogen - hypothetical protein Acid_4871 1 None None None 116619448 Common - glycogen/starch synthases, ADP-glucose type Acid_0307 135 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 116623533 Nonpathogen - hypothetical protein Acid_4443 1 None None None 116624530 Nonpathogen - biotin/lipoyl attachment domain-containing protein Acid_5454 1 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 116625708 Common - GCN5-related N-acetyltransferase Acid_6657 13 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 116626022 Common - dihydrodipicolinate synthase Acid_6980 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 116623958 Common - aquaporin Z Acid_4870 133 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 116626316 Common - thiamine pyrophosphate enzyme domain protein TPP-binding Acid_7276 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 116624782 Nonpathogen - hypothetical protein Acid_5706 2 None None None 116624153 Nonpathogen - hypothetical protein Acid_5069 1 None None None 116623587 Common - serine/threonine protein kinase Acid_4497 157 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116623437 Common - Amidase Acid_4346 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 116624742 Nonpathogen - hypothetical protein Acid_5666 2 None None None 116619776 Common - IstB domain protein ATP-binding protein Acid_0646 93 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 116622520 Common - HNH endonuclease Acid_3418 103 COG1403 McrA, Restriction endonuclease Defense mechanisms 116623402 Nonpathogen - hypothetical protein Acid_4311 5 None None None 116619603 Common - ATP synthase F1, gamma subunit Acid_0464 207 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 116619679 Nonpathogen - hypothetical protein Acid_0542 1 None None None 116620524 Nonpathogen - hypothetical protein Acid_1402 2 None None None 116621014 Nonpathogen - hypothetical protein Acid_1895 1 None None None 116621419 Common - protein of unknown function DUF1175 Acid_2301 13 COG3234 COG3234, Uncharacterized protein conserved in bacteria Function unknown 116625478 Common - DNA internalization-related competence protein ComEC/Rec2 Acid_6424 126 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 116622835 Nonpathogen - hypothetical protein Acid_3735 5 None None None 116623165 Nonpathogen - hypothetical protein Acid_4071 1 None None None 116625909 Nonpathogen - hypothetical protein Acid_6865 2 None None None 116619672 Common - hypothetical protein Acid_0535 3 COG1554 ATH1, Trehalose and maltose hydrolases (possible phosphorylases) Carbohydrate transport and metabolism 116625585 Nonpathogen - hypothetical protein Acid_6534 1 None None None 116622164 Common - transcriptional regulator, PadR-like family Acid_3056 51 COG1695 COG1695, Predicted transcriptional regulators Transcription 116621713 Common - Xylose isomerase domain protein TIM barrel Acid_2595 21 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116621912 Common - peptidase M28 Acid_2797 22 COG2234 Iap, Predicted aminopeptidases General function prediction only 116624169 Common - multi-sensor signal transduction histidine kinase Acid_5085 182 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116626309 Common - Methyltransferase type 12 Acid_7269 67 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116622718 Common - hypothetical protein Acid_3617 6 COG4758 COG4758, Predicted membrane protein Function unknown 116621169 Common - DNA uptake protein and related DNA-binding protein-like protein Acid_2050 27 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 116622650 Nonpathogen - hypothetical protein Acid_3549 2 None None None 116625254 Nonpathogen - hypothetical protein Acid_6199 4 COG4634 COG4634, Uncharacterized protein conserved in bacteria Function unknown 116623952 Common - hypothetical protein Acid_4864 4 None None None 116626593 Nonpathogen - hypothetical protein Acid_7556 1 None None None 116619511 Nonpathogen - anti-ECFsigma factor, ChrR Acid_0370 1 COG3806 ChrR, Transcriptional activator Transcription 116621210 Common - TonB-dependent receptor Acid_2091 23 None None None 116619470 Common - flagellin domain protein Acid_0329 146 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 116623945 Common - glycosyl transferase, group 1 Acid_4857 227 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116626542 Nonpathogen - hypothetical protein Acid_7505 2 None None None 116619668 Common - histidine kinase Acid_0531 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116625217 Common - FG-GAP repeat protein Acid_6162 22 None None None 116624507 Common - Cna B domain protein Acid_5431 26 None None None 116624944 Common - glycoside hydrolase family 2, sugar binding Acid_5873 74 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 116620246 Nonpathogen - Fibronectin, type III domain protein Acid_1123 2 None None None 116620665 Common - putative transmembrane protein Acid_1545 15 None None None 116623334 Common - serine/threonine protein kinase Acid_4243 111 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116620112 Common - peptidyl-prolyl cis-trans isomerase, cyclophilin type Acid_0985 164 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 116619664 Common - anti-sigma-factor antagonist Acid_0527 33 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 116619830 Common - protein of unknown function DUF214 Acid_0700 36 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116626215 Common glpX fructose 1,6-bisphosphatase II Acid_7175 112 COG1494 GlpX, Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins Carbohydrate transport and metabolism 116626729 Common - FeS assembly protein SufD Acid_7701 172 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 116625911 Common - glycoside hydrolase, family 28 Acid_6868 23 COG5434 PGU1, Endopygalactorunase Cell envelope biogenesis, outer membrane 116619999 Common - serine/threonine protein kinase Acid_0871 155 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116619760 Common - conserved repeat domain Acid_0626 105 None None None 116626574 Common - Ferric reductase domain protein transmembrane component, N-terminal domain Acid_7537 75 COG2717 COG2717, Predicted membrane protein Function unknown 116626823 Nonpathogen - protein of unknown function DUF214 Acid_7796 4 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116625389 Nonpathogen - hypothetical protein Acid_6334 1 None None None 116620763 Common - Cna B domain protein Acid_1644 5 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116626125 Common - 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family Acid_7083 105 COG1778 COG1778, Low specificity phosphatase (HAD superfamily) General function prediction only 116622098 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Acid_2985 83 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116626846 Common - lipolytic enzyme, G-D-S-L family Acid_7819 24 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116626148 Common - Transposase and inactivated derivatives-like protein Acid_7107 20 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 116619290 Nonpathogen - hypothetical protein Acid_0146 5 None None None 116622368 Common - serine/threonine protein kinase with TPR repeats Acid_3262 164 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116624647 Nonpathogen - hypothetical protein Acid_5571 4 None None None 116624987 Nonpathogen - hypothetical protein Acid_5917 1 None None None 116626835 Nonpathogen - hypothetical protein Acid_7808 1 None None None 116620845 Common - Tetratricopeptide TPR_2 repeat protein Acid_1726 44 COG4995 COG4995, Uncharacterized protein conserved in bacteria Function unknown 116622710 Common - dipeptidyl aminopeptidase/acylaminoacyl-peptidase-like protein Acid_3609 27 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116624840 Common - hypothetical protein Acid_5764 20 COG5552 COG5552, Uncharacterized conserved protein Function unknown 116625180 Common - Resolvase, N-terminal domain Acid_6125 131 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 116620469 Common - transcriptional regulator, Fis family Acid_1347 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 116625902 Nonpathogen - hypothetical protein Acid_6858 1 None None None 116625337 Common - two component transcriptional regulator, winged helix family Acid_6282 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116621573 Common - serine/threonine protein kinase Acid_2455 154 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116625330 Common - Adenylosuccinate synthase Acid_6275 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 116619456 Common - 2'-5' RNA ligase Acid_0315 96 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 116619480 Common - flagellar hook-basal body complex subunit FliE Acid_0339 69 COG1677 FliE, Flagellar hook-basal body protein Cell motility and secretion / Intracellular trafficking and secretion 116623761 Common - Tetratricopeptide TPR_2 repeat protein Acid_4673 139 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116624135 Common - glycosyl hydrolase, BNR repeat Acid_5051 39 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116621742 Common - outer membrane efflux protein Acid_2624 97 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116626365 Nonpathogen - hypothetical protein Acid_7325 1 None None None 116621605 Nonpathogen - hypothetical protein Acid_2487 1 None None None 116624343 Common - anti-sigma-factor antagonist Acid_5261 60 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 116619380 Common - protein of unknown function DUF1305 Acid_0238 46 COG3520 COG3520, Uncharacterized protein conserved in bacteria Function unknown 116619948 Common - O-methyltransferase, family 2 Acid_0820 57 COG5459 COG5459, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 116625429 Common - formylmethanofuran dehydrogenase, subunit E region Acid_6374 33 COG2191 COG2191, Formylmethanofuran dehydrogenase subunit E Energy production and conversion 116619568 Nonpathogen - hypothetical protein Acid_0429 1 None None None 116622373 Common - Methyltransferase type 11 Acid_3267 128 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116623728 Common - ABC-2 type transporter Acid_4640 109 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116626720 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit beta Acid_7692 108 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 116625288 Common - glycosyl transferase, group 1 Acid_6233 42 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116619544 Nonpathogen - hypothetical protein Acid_0403 5 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 116620078 Common - serine/threonine protein kinase Acid_0950 147 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116620794 Common - Rieske (2Fe-2S) domain protein Acid_1675 79 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 116624901 Nonpathogen - protein of unknown function DUF1552 Acid_5826 6 None None None 116625242 Common - protein of unknown function DUF1501 Acid_6187 5 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116625837 Nonpathogen - hypothetical protein Acid_6790 1 None None None 116624081 Common - hypothetical protein Acid_4995 16 COG4912 COG4912, Predicted DNA alkylation repair enzyme DNA replication, recombination, and repair 116619957 Common - putative esterase Acid_0829 13 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 116623577 Common - ABC transporter related Acid_4487 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 116623658 Common - phage shock protein A, PspA Acid_4570 69 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 116622506 Common - transcriptional regulator, TraR/DksA family Acid_3404 122 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 116624521 Common - glycosyl transferase, family 39 Acid_5445 5 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116621486 Common - binding-protein-dependent transport systems inner membrane component Acid_2368 186 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 116619300 Common - formyltetrahydrofolate deformylase Acid_0156 218 COG0788 PurU, Formyltetrahydrofolate hydrolase Nucleotide transport and metabolism 116624256 Common - ROK family protein Acid_5174 162 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 116626808 Nonpathogen - hypothetical protein Acid_7781 1 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 116624485 Nonpathogen - hypothetical protein Acid_5407 3 COG5373 COG5373, Predicted membrane protein Function unknown 116624730 Common - O-methyltransferase, family 2 Acid_5654 22 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 116625166 Nonpathogen - hypothetical protein Acid_6110 1 None None None 116620189 Common - general secretion pathway protein G Acid_1062 13 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 116621160 Common - two component, sigma54 specific, transcriptional regulator, Fis family Acid_2041 217 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116621800 Nonpathogen - hypothetical protein Acid_2682 1 None None None 116619273 Common - response regulator receiver and unknown domain protein Acid_0129 74 COG4565 CitB, Response regulator of citrate/malate metabolism Transcription / Signal transduction mechanisms 116620476 Common - YceI family protein Acid_1354 17 COG2353 COG2353, Uncharacterized conserved protein Function unknown 116626242 Nonpathogen - hypothetical protein Acid_7202 1 None None None 116625596 Nonpathogen - hypothetical protein Acid_6545 3 COG1724 COG1724, Predicted periplasmic or secreted lipoprotein Cell motility and secretion 116622529 Common - glycoside hydrolase, family 5 Acid_3427 24 COG2730 BglC, Endoglucanase Carbohydrate transport and metabolism 116623355 Common - short chain dehydrogenase Acid_4264 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116622926 Common - glycosyl transferase, family 2 Acid_3828 177 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116622979 Common - short-chain dehydrogenase/reductase SDR Acid_3882 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116624251 Common - peptidase M50 Acid_5169 37 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 116623570 Common - transcriptional regulator, AraC family Acid_4480 145 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 116619921 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_0793 171 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116626874 Common - integral membrane protein-like protein Acid_7849 18 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 116620180 Nonpathogen - hypothetical protein Acid_1053 1 None None None 116621866 Nonpathogen - hypothetical protein Acid_2749 1 None None None 116620316 Common ispG 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase Acid_1193 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 116625743 Common - hypothetical protein Acid_6693 22 COG3794 PetE, Plastocyanin Energy production and conversion 116619643 Common - peptidase M16 domain protein Acid_0504 182 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 116620327 Common - binding-protein-dependent transport systems inner membrane component Acid_1204 135 COG1174 OpuBB, ABC-type proline/glycine betaine transport systems, permease component Amino acid transport and metabolism 116621265 Nonpathogen - hypothetical protein Acid_2146 2 None None None 116621514 Common - peptidyl-prolyl cis-trans isomerase, cyclophilin type Acid_2396 87 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 116623337 Nonpathogen - hypothetical protein Acid_4246 1 None None None 116624668 Common - cytochrome c oxidase, subunit III Acid_5592 159 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 116626785 Common - hypothetical protein Acid_7758 15 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116625058 Common - secretion protein HlyD family protein Acid_5988 164 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116619520 Common - Endonuclease/exonuclease/phosphatase Acid_0379 80 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 116624735 Common - phospholipid/glycerol acyltransferase Acid_5659 207 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 116622439 Nonpathogen - aminoglycoside phosphotransferase Acid_3337 1 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 116620759 Common - peptidase M14, carboxypeptidase A Acid_1640 13 None None None 116626467 Common - Alcohol dehydrogenase, zinc-binding domain protein Acid_7430 188 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 116623225 Common - GCN5-related N-acetyltransferase Acid_4132 54 COG3153 COG3153, Predicted acetyltransferase General function prediction only 116622916 Common - transcriptional regulator, LysR family Acid_3817 185 COG0583 LysR, Transcriptional regulator Transcription 116625543 Common - putative transcriptional regulator Acid_6490 152 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 116624520 Nonpathogen - glycosyl transferase, family 39 Acid_5444 3 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116620314 Nonpathogen - hypothetical protein Acid_1191 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116620593 Common - glycoside hydrolase, clan GH-D Acid_1472 15 COG3345 GalA, Alpha-galactosidase Carbohydrate transport and metabolism 116621887 Nonpathogen - tetratricopeptide repeat protein Acid_2770 2 None None None 116623541 Common - oxidoreductase domain protein Acid_4451 170 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116623682 Common - transcriptional regulator, MarR family Acid_4594 70 COG1846 MarR, Transcriptional regulators Transcription 116621932 Nonpathogen - hypothetical protein Acid_2817 1 None None None 116626556 Common - protein serine/threonine phosphatase Acid_7519 120 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 116621452 Common - peptidase M48, Ste24p Acid_2334 189 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 116624749 Nonpathogen - hypothetical protein Acid_5673 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116625937 Common - two component transcriptional regulator, winged helix family Acid_6895 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116624230 Nonpathogen - hypothetical protein Acid_5147 11 None None None 116622472 Nonpathogen - hypothetical protein Acid_3370 2 None None None 116619739 Common - transcriptional regulator, TetR family Acid_0604 58 COG1309 AcrR, Transcriptional regulator Transcription 116626195 Nonpathogen - Methyltransferase type 12 Acid_7155 7 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116623212 Nonpathogen - hypothetical protein Acid_4119 1 COG4718 COG4718, Phage-related protein Function unknown 116620398 Common - ABC transporter related Acid_1275 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116626532 Common - glycosyl transferase, family 2 Acid_7495 194 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116625566 Common - sulfate adenylyltransferase, large subunit Acid_6513 249 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 116626281 Nonpathogen - hypothetical protein Acid_7241 1 None None None 116626502 Common - flagellar biosynthesis protein FlhA Acid_7465 127 COG1298 FlhA, Flagellar biosynthesis pathway, component FlhA Cell motility and secretion / Intracellular trafficking and secretion 116620650 Common - tartrate dehydrogenase Acid_1530 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 116625976 Common - ABC transporter related Acid_6934 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 116623241 Common - ABC transporter related Acid_4148 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 116623894 Common - glutaredoxin 2 Acid_4806 20 None None None 116620606 Common - Inositol 2-dehydrogenase Acid_1485 186 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116623075 Common - GntR domain protein Acid_3979 125 COG2186 FadR, Transcriptional regulators Transcription 116623597 Common - alpha amylase, catalytic region Acid_4507 67 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 116626509 Common - Cupin 2, conserved barrel domain protein Acid_7472 47 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 116621360 Common - oxidoreductase domain protein Acid_2241 170 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116624760 Common - NADH dehydrogenase I, D subunit Acid_5684 192 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 116624345 Common - Amidase Acid_5263 220 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 116623847 Common anmK anhydro-N-acetylmuramic acid kinase Acid_4759 120 COG2377 COG2377, Predicted molecular chaperone distantly related to HSP70-fold metalloproteases Posttranslational modification, protein turnover, chaperones 116623156 Common - cell surface receptor IPT/TIG domain protein Acid_4062 40 None None None 116621873 Common - lipolytic enzyme, G-D-S-L family Acid_2756 18 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116622432 Nonpathogen - hypothetical protein Acid_3330 3 COG2948 VirB10, Type IV secretory pathway, VirB10 components Intracellular trafficking and secretion 116625390 Common - hypothetical protein Acid_6335 71 COG2706 COG2706, 3-carboxymuconate cyclase Carbohydrate transport and metabolism 116625471 Nonpathogen - type IV pilus assembly PilZ Acid_6417 1 None None None 116622479 Common - succinyl-CoA synthetase, alpha subunit Acid_3377 208 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 116624198 Common - ribosomal protein S19 Acid_5114 247 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 116623512 Common - Strictosidine synthase Acid_4422 46 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116621192 Common - putative esterase Acid_2073 66 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 116620142 Nonpathogen - plasmid stabilization system Acid_1015 3 COG2026 RelE, Cytotoxic translational repressor of toxin-antitoxin stability system Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning 116620337 Common - sugar transferase Acid_1214 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 116619800 Common - hypothetical protein Acid_0670 26 None None None 116626263 Common - Rubrerythrin Acid_7223 23 COG1633 COG1633, Uncharacterized conserved protein Function unknown 116619591 Common - protein of unknown function DUF224, cysteine-rich region domain protein Acid_0452 182 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 116626428 Common - short-chain dehydrogenase/reductase SDR Acid_7390 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116621181 Common - putative transcriptional regulator, XRE family Acid_2062 25 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 116626209 Nonpathogen - hypothetical protein Acid_7169 3 None None None 116624196 Common - ribosomal protein S3 Acid_5112 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 116625790 Nonpathogen - Ankyrin Acid_6740 3 None None None 116619841 Nonpathogen - NAD-dependent epimerase/dehydratase Acid_0711 5 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116620340 Nonpathogen - protein of unknown function DUF1555 Acid_1217 1 None None None 116623920 Common - von Willebrand factor, type A Acid_4832 11 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 116624228 Nonpathogen - putative signal peptide protein Acid_5145 1 None None None 116624942 Common - TonB-dependent receptor, plug Acid_5869 24 None None None 116622312 Common - PAS/PAC sensor hybrid histidine kinase Acid_3206 224 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116620030 Common - homoserine kinase Acid_0902 121 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 116620287 Common - transcriptional regulator, TraR/DksA family Acid_1164 83 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 116625462 Common - Polynucleotide adenylyltransferase region Acid_6407 154 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 116619937 Common - ROK family protein Acid_0809 140 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 116620648 Common - sulfatase Acid_1528 86 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116619323 Common - acetolactate synthase, large subunit, biosynthetic type Acid_0180 222 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 116620830 Nonpathogen - hypothetical protein Acid_1711 1 None None None 116626576 Common - RNP-1 like RNA-binding protein Acid_7539 66 COG0724 COG0724, RNA-binding proteins (RRM domain) General function prediction only 116623315 Common - riboflavin synthase subunit alpha Acid_4223 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 116624812 Common - SEC-C motif domain protein Acid_5736 17 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 116622454 Common - hydrolase, TatD family Acid_3352 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 116625918 Common - TonB-dependent receptor Acid_6875 22 None None None 116620899 Nonpathogen - hypothetical protein Acid_1780 2 None None None 116622478 Common - Nucleoside-diphosphate kinase Acid_3376 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 116623928 Common - Cna B domain protein Acid_4840 24 None None None 116623960 Nonpathogen - helix-hairpin-helix motif protein Acid_4872 2 None None None 116621661 Common - eRF1 domain 3 protein Acid_2543 6 COG1503 eRF1, Peptide chain release factor 1 (eRF1) Translation, ribosomal structure and biogenesis 116624505 Common - acriflavin resistance protein Acid_5429 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116620347 Nonpathogen - peptidase M10A and M12B, matrixin and adamalysin Acid_1224 5 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 116626239 Nonpathogen - PDZ/DHR/GLGF domain protein Acid_7199 5 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 116625160 Common - phage integrase family protein Acid_6102 226 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116621672 Common - RNA-directed DNA polymerase Acid_2554 93 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 116626825 Common - response regulator receiver protein Acid_7798 178 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116619895 Nonpathogen - H+-transporting two-sector ATPase, C subunit Acid_0767 4 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 116625205 Common - ApbE family lipoprotein Acid_6150 139 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 116623714 Common - hypothetical protein Acid_4626 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116625145 Common - Extracellular ligand-binding receptor Acid_6083 116 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 116620108 Common - Heat shock protein 70 Acid_0981 234 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 116623267 Nonpathogen - PilT protein domain protein Acid_4174 1 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 116622394 Common - 3-demethylubiquinone-9 3-methyltransferase Acid_3288 64 COG3865 COG3865, Uncharacterized protein conserved in bacteria Function unknown 116626676 Nonpathogen - hypothetical protein Acid_7646 1 None None None 116622017 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Acid_2902 116 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 116626960 Common - ABC transporter related Acid_7937 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 116621496 Common - beta-lactamase Acid_2378 54 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116622089 Common - aldo/keto reductase Acid_2976 184 COG1453 COG1453, Predicted oxidoreductases of the aldo/keto reductase family General function prediction only 116626471 Nonpathogen - hypothetical protein Acid_7434 2 None None None 116620168 Common - 6-pyruvoyl tetrahydropterin synthase and hypothetical protein Acid_1041 146 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 116625225 Common - two component transcriptional regulator, LuxR family Acid_6170 73 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116626320 Nonpathogen - hypothetical protein Acid_7280 1 None None None 116620824 Nonpathogen - conserved hypothetical protein, signal peptide and transmembrane prediction Acid_1705 2 None None None 116623370 Common - beta-lactamase domain protein Acid_4279 8 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 116626940 Common - methyltransferase GidB Acid_7917 203 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 116625244 Common - response regulator receiver protein Acid_6189 216 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116619848 Common - beta-lactamase domain protein Acid_0720 71 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 116622943 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Acid_3845 198 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 116619227 Nonpathogen - hypothetical protein Acid_0082 1 None None None 116621377 Common - dihydrodipicolinate synthetase Acid_2258 234 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 116620839 Nonpathogen - hypothetical protein Acid_1720 9 None None None 116619361 Common - glycogen debranching enzyme GlgX Acid_0219 160 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 116620006 Common - TPR repeat-containing protein Acid_0878 25 None None None 116620765 Common - multi-sensor signal transduction histidine kinase Acid_1646 223 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116623776 Common - protein of unknown function DUF214 Acid_4688 12 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116624401 Common - Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein Acid_5323 130 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116624550 Common - cyclase/dehydrase Acid_5474 32 COG4276 COG4276, Uncharacterized conserved protein Function unknown 116623044 Nonpathogen - hypothetical protein Acid_3948 1 None None None 116623097 Common - transcriptional regulator, AraC family Acid_4001 120 COG0122 AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 116624656 Common - putative transmembrane protein Acid_5580 8 COG4758 COG4758, Predicted membrane protein Function unknown 116620687 Common - competence/damage-inducible protein CinA Acid_1567 213 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 116621460 Common - Methyltransferase type 11 Acid_2342 88 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116624989 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Acid_5919 2 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116620452 Common - Propanediol utilization protein Acid_1330 36 COG4869 PduL, Propanediol utilization protein Secondary metabolites biosynthesis, transport, and catabolism 116623397 Nonpathogen - protein of unknown function DUF1552 Acid_4306 6 None None None 116623082 Common - PKD domain containing protein Acid_3986 11 COG3291 COG3291, FOG: PKD repeat General function prediction only 116623865 Common - histidine kinase Acid_4777 225 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116619610 Common - Smr protein/MutS2 Acid_0471 29 COG1193 COG1193, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 116620154 Nonpathogen - hypothetical protein Acid_1027 1 None None None 116626335 Common - threonyl-tRNA synthetase Acid_7295 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116624594 Common - acriflavin resistance protein Acid_5518 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116621745 Common - protein of unknown function DUF1080 Acid_2627 9 None None None 116620069 Common - transcriptional regulator, XRE family Acid_0941 28 COG5606 COG5606, Uncharacterized conserved small protein Function unknown 116619939 Nonpathogen - Xylose isomerase domain protein TIM barrel Acid_0811 8 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116621818 Common - short-chain dehydrogenase/reductase SDR Acid_2700 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116626667 Common - serine/threonine protein kinase Acid_7636 156 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116620938 Nonpathogen - hypothetical protein Acid_1819 5 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116624912 Common - YbaK/prolyl-tRNA synthetase associated region Acid_5838 32 COG2606 EbsC, Uncharacterized conserved protein Function unknown 116620063 Common - cell well associated RhsD protein precursor Acid_0935 10 None None None 116623747 Nonpathogen - hypothetical protein Acid_4659 3 None None None 116622873 Common - multi-sensor hybrid histidine kinase Acid_3774 224 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116624277 Nonpathogen - hypothetical protein Acid_5195 1 None None None 116621613 Common - thiol oxidoreductase-like protein Acid_2495 49 COG3488 COG3488, Predicted thiol oxidoreductase Energy production and conversion 116621293 Nonpathogen - hypothetical protein Acid_2174 3 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 116624572 Nonpathogen - hypothetical protein Acid_5496 1 None None None 116620635 Nonpathogen - integral membrane protein-like protein Acid_1514 1 COG5617 COG5617, Predicted integral membrane protein Function unknown 116624032 Common - amino acid permease-associated region Acid_4944 184 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116619729 Common - WD40 domain protein beta Propeller Acid_0594 94 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116619263 Common - proton-translocating NADH-quinone oxidoreductase, chain M Acid_0119 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 116624555 Common - hypothetical protein Acid_5479 7 COG2442 COG2442, Uncharacterized conserved protein Function unknown 116621287 Common - Tetratricopeptide TPR_2 repeat protein Acid_2168 22 COG4785 NlpI, Lipoprotein NlpI, contains TPR repeats General function prediction only 116622586 Common - Tetratricopeptide TPR_2 repeat protein Acid_3484 39 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116625646 Common - hypothetical protein Acid_6595 2 None None None 116623840 Common - phage integrase family protein Acid_4752 224 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116624125 Common - protein of unknown function DUF1501 Acid_5041 14 COG4102 COG4102, Uncharacterized protein conserved in bacteria Function unknown 116620132 Common - protein of unknown function UPF0227 Acid_1005 45 COG1647 COG1647, Esterase/lipase General function prediction only 116621944 Nonpathogen - hypothetical protein Acid_2829 1 None None None 116619857 Common - outer membrane efflux protein Acid_0729 81 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116621469 Common - phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase Acid_2351 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 116625302 Common - oxidoreductase domain protein Acid_6247 25 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116624963 Common - Radical SAM domain protein Acid_5892 60 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116625882 Nonpathogen - hypothetical protein Acid_6836 1 None None None 116625628 Common - hypothetical protein Acid_6577 52 None None None 116620202 Nonpathogen - hypothetical protein Acid_1075 1 None None None 116621587 Nonpathogen - hypothetical protein Acid_2469 1 None None None 116622190 Nonpathogen - hypothetical protein Acid_3082 1 None None None 116622241 Nonpathogen - hypothetical protein Acid_3134 1 None None None 116624374 Nonpathogen - hypothetical protein Acid_5295 4 None None None 116625152 Common - Amidohydrolase 3 Acid_6092 104 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 116620629 Common - Acetamidase/Formamidase Acid_1508 57 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 116626079 Common - RecA domain protein Acid_7037 207 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 116621112 Nonpathogen - hypothetical protein Acid_1993 3 COG5277 COG5277, Actin and related proteins Cytoskeleton 116623163 Common - isopropylmalate isomerase large subunit Acid_4069 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 116625755 Common - protein of unknown function DUF151 Acid_6705 78 COG1259 COG1259, Uncharacterized conserved protein Function unknown 116625648 Nonpathogen - hypothetical protein Acid_6597 1 None None None 116620293 Common - conserved hypothetical protein, transmembrane prediction Acid_1170 7 None None None 116626222 Nonpathogen - hypothetical protein Acid_7182 1 None None None 116621938 Common - amino acid transporters Acid_2823 49 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116625133 Common - transposase IS3/IS911 family protein Acid_6070 51 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 116623857 Nonpathogen - hypothetical protein Acid_4769 1 None None None 116622862 Nonpathogen - peptidase domain protein Acid_3763 4 None None None 116625023 Common - hypothetical protein Acid_5953 8 None None None 116623248 Nonpathogen - hypothetical protein Acid_4155 1 None None None 116625102 Nonpathogen - hypothetical protein Acid_6038 1 None None None 116620371 Common - hypothetical protein Acid_1248 108 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 116624227 Nonpathogen - hypothetical protein Acid_5143 1 None None None 116626895 Common - polysaccharide deacetylase Acid_7872 5 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 116623205 Nonpathogen - hypothetical protein Acid_4112 1 None None None 116624282 Common - alpha/beta hydrolase fold Acid_5200 98 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 116621137 Nonpathogen - hypothetical protein Acid_2018 3 None None None 116626788 Nonpathogen - hypothetical protein Acid_7761 1 None None None 116623421 Common - conserved hypothetical protein, predicted transcription regulator Acid_4330 27 COG5499 COG5499, Predicted transcription regulator containing HTH domain Transcription 116626903 Common - Ankyrin Acid_7880 122 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 116625260 Common - oxidoreductase domain protein Acid_6205 156 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116623653 Nonpathogen - hypothetical protein Acid_4565 2 None None None 116622498 Common - transcriptional regulator, AraC family Acid_3396 117 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 116621540 Common - hypothetical protein Acid_2422 2 None None None 116625399 Common - protein of unknown function DUF418 Acid_6344 58 COG2311 COG2311, Predicted membrane protein Function unknown 116623215 Common - hypothetical protein Acid_4122 2 COG4386 COG4386, Mu-like prophage tail sheath protein gpL General function prediction only 116619961 Common - conserved hypothetical protein, with unknown function Acid_0833 9 COG4453 COG4453, Uncharacterized protein conserved in bacteria Function unknown 116621158 Nonpathogen - hypothetical protein Acid_2039 1 None None None 116624619 Common - gluconate transporter Acid_5543 77 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 116625459 Common - TPR repeat-containing protein Acid_6404 49 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116624088 Common - peptidase M48, Ste24p Acid_5002 110 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116626066 Common - NIPSNAP family containing protein Acid_7024 8 None None None 116623726 Common - polysaccharide export protein Acid_4638 99 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 116626340 Common - protein of unknown function UPF0047 Acid_7300 137 COG0432 COG0432, Uncharacterized conserved protein Function unknown 116621807 Nonpathogen - hypothetical protein Acid_2689 1 None None None 116626301 Common - Abortive infection protein Acid_7261 22 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 116621529 Common - GCN5-related N-acetyltransferase Acid_2411 32 COG0456 RimI, Acetyltransferases General function prediction only 116626410 Nonpathogen - hypothetical protein Acid_7372 2 None None None 116619815 Common - NADH:flavin oxidoreductase/NADH oxidase Acid_0685 177 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 116621795 Common - hypothetical protein Acid_2677 10 None None None 116624985 Common - arsenite-activated ATPase ArsA Acid_5915 98 COG0003 ArsA, Predicted ATPase involved in chromosome partitioning Cell division and chromosome partitioning 116626049 Nonpathogen - hypothetical protein Acid_7007 10 COG1874 LacA, Beta-galactosidase Carbohydrate transport and metabolism 116623252 Common - type II secretion system protein Acid_4159 82 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 116622614 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_3512 114 COG0348 NapH, Polyferredoxin Energy production and conversion 116623365 Common - serine/threonine protein kinase Acid_4274 149 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116620420 Common - tRNA delta(2)-isopentenylpyrophosphate transferase Acid_1297 214 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 116622436 Common - 40-residue YVTN family beta-propeller repeat protein Acid_3334 83 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116623492 Common - dihydroorotate dehydrogenase family protein Acid_4402 236 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 116622821 Common - peptidase S58, DmpA Acid_3721 37 COG3191 DmpA, L-aminopeptidase/D-esterase Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116625534 Common - ABC transporter related Acid_6481 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 116620219 Common - metallophosphoesterase Acid_1096 46 COG1409 Icc, Predicted phosphohydrolases General function prediction only 116620351 Common - hypothetical protein Acid_1228 29 COG3595 COG3595, Uncharacterized conserved protein Function unknown 116622974 Common - Integrase, catalytic region Acid_3877 78 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 116622837 Common - peptidase S9, prolyl oligopeptidase active site domain protein Acid_3737 88 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116622840 Common - MATE efflux family protein Acid_3740 176 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 116623678 Nonpathogen - hypothetical protein Acid_4590 1 None None None 116621535 Nonpathogen - hypothetical protein Acid_2417 1 None None None 116624780 Common - 2-isopropylmalate synthase Acid_5704 212 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 116625850 Nonpathogen - hypothetical protein Acid_6804 1 None None None 116620744 Common - Integrase, catalytic region Acid_1625 153 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116625691 Common - transcriptional regulator, NifA subfamily, Fis Family Acid_6640 176 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 116624547 Common - serine/threonine protein kinase Acid_5471 193 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116622460 Common - hypothetical protein Acid_3358 24 None None None 116622666 Common - hypothetical protein Acid_3565 20 None None None 116621788 Nonpathogen - hypothetical protein Acid_2670 1 None None None 116626496 Common - surface presentation of antigens (SPOA) protein Acid_7459 111 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 116625043 Common - peptidase U62, modulator of DNA gyrase Acid_5973 165 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 116626297 Nonpathogen - hypothetical protein Acid_7257 1 None None None 116619569 Nonpathogen - hypothetical protein Acid_0430 1 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116623821 Common - Integrase, catalytic region Acid_4733 151 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116626132 Common - Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B Acid_7090 88 COG3384 COG3384, Uncharacterized conserved protein Function unknown 116619820 Common - primosomal protein N' Acid_0690 215 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 116622319 Nonpathogen - hypothetical protein Acid_3213 1 None None None 116625120 Nonpathogen - conserved repeat domain Acid_6057 6 None None None 116621245 Nonpathogen - hypothetical protein Acid_2126 1 None None None 116626375 Common - glycogen branching enzyme Acid_7335 148 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 116619809 Common - putative NADH-dependent dehydrogenase Acid_0679 31 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116623133 Nonpathogen - hypothetical protein Acid_4039 4 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 116625212 Common - peptidase M19, renal dipeptidase Acid_6157 101 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 116621097 Common - transcriptional regulator, Fis family Acid_1978 139 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116623519 Nonpathogen - hypothetical protein Acid_4429 1 None None None 116625483 Common - hypothetical protein Acid_6429 5 None None None 116625921 Nonpathogen - hypothetical protein Acid_6878 1 None None None 116623882 Common - Cystathionine gamma-synthase Acid_4794 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 116621655 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_2537 150 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116625868 Common - Integrase, catalytic region Acid_6822 153 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116622461 Common - hypothetical protein Acid_3359 4 None None None 116620301 Common - metallophosphoesterase Acid_1178 81 COG1692 COG1692, Uncharacterized protein conserved in bacteria Function unknown 116621774 Nonpathogen - hypothetical protein Acid_2656 10 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116624777 Common - isocitrate lyase Acid_5701 128 COG2224 AceA, Isocitrate lyase Energy production and conversion 116626624 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_7587 67 COG3336 COG3336, Predicted membrane protein Function unknown 116624949 Common - peptidyl-prolyl cis-trans isomerase, cyclophilin type Acid_5878 81 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 116619850 Nonpathogen - hypothetical protein Acid_0722 4 COG4818 COG4818, Predicted membrane protein Function unknown 116624294 Nonpathogen - hypothetical protein Acid_5212 2 None None None 116626204 Common - Heparinase II/III family protein Acid_7164 19 None None None 116620870 Common - multi-sensor hybrid histidine kinase Acid_1751 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116626543 Common - Pyridoxal-5'-phosphate-dependent enzyme, beta subunit Acid_7506 230 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 116626659 Nonpathogen - hypothetical protein Acid_7628 1 None None None 116624906 Common - hypothetical protein Acid_5832 10 None None None 116622280 Common - serine/threonine protein kinase Acid_3174 155 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116622855 Nonpathogen - Cupin 2, conserved barrel domain protein Acid_3756 13 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 116624601 Nonpathogen - hypothetical protein Acid_5525 1 None None None 116620089 Nonpathogen - hypothetical protein Acid_0961 8 COG4276 COG4276, Uncharacterized conserved protein Function unknown 116620248 Common - hypothetical protein Acid_1125 5 None None None 116621734 Nonpathogen - hypothetical protein Acid_2616 8 None None None 116620273 Nonpathogen - hypothetical protein Acid_1150 1 None None None 116623525 Common - hypothetical protein Acid_4435 8 None None None 116619930 Common - hypothetical protein Acid_0802 177 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116620571 Common - oxidoreductase, molybdopterin binding Acid_1449 123 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 116621395 Common - ABC transporter related Acid_2277 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 116619210 Common - beta-lactamase Acid_0065 140 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116623428 Common - phage shock protein C, PspC Acid_4337 30 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 116623876 Nonpathogen - type IV pilus assembly PilZ Acid_4788 1 None None None 116625785 Common - hypothetical protein Acid_6735 3 None None None 116626947 Common - hypothetical protein Acid_7924 3 None None None 116621130 Common - alanine racemase domain protein Acid_2011 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 116621668 Common - oxidoreductase domain protein Acid_2550 55 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116621910 Common - hypothetical protein Acid_2795 15 None None None 116625098 Nonpathogen - hypothetical protein Acid_6034 1 None None None 116626887 Common - fumarylacetoacetate (FAA) hydrolase Acid_7863 174 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 116622252 Nonpathogen - hypothetical protein Acid_3145 1 None None None 116619553 Common - deoxyuridine 5'-triphosphate nucleotidohydrolase Dut Acid_0414 186 COG0756 Dut, dUTPase Nucleotide transport and metabolism 116626341 Common - glycoside hydrolase family 2, sugar binding Acid_7301 75 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 116619469 Common - protein of unknown function DUF180 Acid_0328 35 COG1699 COG1699, Uncharacterized protein conserved in bacteria Function unknown 116625070 Common - Resolvase, N-terminal domain Acid_6000 70 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 116626520 Common - chaperone DnaJ domain protein Acid_7483 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 116620693 Common - Activator of Hsp90 ATPase 1 family protein Acid_1573 26 COG3832 COG3832, Uncharacterized conserved protein Function unknown 116621057 Common - TonB-dependent receptor, plug Acid_1938 23 COG4932 COG4932, Predicted outer membrane protein Cell envelope biogenesis, outer membrane 116623994 Nonpathogen - hypothetical protein Acid_4906 2 None None None 116626567 Common - transcriptional regulator, XRE family Acid_7530 111 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 116622008 Common - phosphoglucomutase Acid_2893 179 COG0033 Pgm, Phosphoglucomutase Carbohydrate transport and metabolism 116624384 Nonpathogen - hypothetical protein Acid_5305 1 None None None 116621147 Common - small GTP-binding protein Acid_2028 222 COG0218 COG0218, Predicted GTPase General function prediction only 116622181 Common - dienelactone hydrolase Acid_3073 74 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 116620269 Common - protein of unknown function DUF1501 Acid_1146 7 COG4102 COG4102, Uncharacterized protein conserved in bacteria Function unknown 116623788 Common - protein of unknown function DUF214 Acid_4700 13 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623815 Common - Cna B domain protein Acid_4727 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116622074 Nonpathogen - hypothetical protein Acid_2961 1 None None None 116622083 Nonpathogen - hypothetical protein Acid_2970 1 None None None 116620329 Common - 6-phosphogluconate dehydrogenase-like protein Acid_1206 185 COG1023 Gnd, Predicted 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 116620807 Common - Type II site-specific deoxyribonuclease Acid_1688 15 None None None 116625282 Common - dTDP-4-dehydrorhamnose 3,5-epimerase related Acid_6227 150 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 116620402 Common - protein-export membrane protein SecF Acid_1279 217 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 116622410 Common - aldo/keto reductase Acid_3305 201 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116619674 Common - methylated-DNA-(protein)-cysteine S-methyltransferase Acid_0537 47 COG3695 COG3695, Predicted methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 116625276 Common - carboxyl-terminal protease Acid_6221 182 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 116624240 Common - transposase IS3/IS911 family protein Acid_5157 32 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 116625232 Common - inner-membrane translocator Acid_6177 108 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 116622492 Nonpathogen - hypothetical protein Acid_3390 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116622203 Common - hypothetical protein Acid_3095 15 COG3828 COG3828, Uncharacterized protein conserved in bacteria Function unknown 116622568 Common - hypothetical protein Acid_3466 3 None None None 116625774 Nonpathogen - hypothetical protein Acid_6724 1 None None None 116619689 Common - beta-propeller repeat protein Acid_0554 39 None None None 116622428 Common - serine/threonine protein kinase Acid_3325 150 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116619374 Common - protein of unknown function DUF877 Acid_0232 50 COG3517 COG3517, Uncharacterized protein conserved in bacteria Function unknown 116621674 Common - Xanthine/uracil/vitamin C permease Acid_2556 135 COG2252 COG2252, Permeases General function prediction only 116621442 Nonpathogen - hypothetical protein Acid_2324 1 None None None 116624412 Common - hypothetical protein Acid_5334 17 None None None 116620195 Common - ribosomal L11 methyltransferase Acid_1068 164 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 116625994 Common - efflux transporter, RND family, MFP subunit Acid_6952 144 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 116622689 Common - conserved hypothetical protein 730 Acid_3588 113 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 116624051 Common - protein of unknown function DUF214 Acid_4965 19 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116619420 Common - Methyltransferase type 11 Acid_0279 45 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116624733 Common - hypothetical protein Acid_5657 3 None None None 116619436 Nonpathogen - hypothetical protein Acid_0295 7 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 116622423 Common - PAS/PAC sensor hybrid histidine kinase Acid_3320 223 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116625252 Common - hypothetical protein Acid_6197 46 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 116620481 Common - glycosyl transferase, group 1 Acid_1359 215 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116626362 Common - hypothetical protein Acid_7322 3 None None None 116622680 Nonpathogen - hypothetical protein Acid_3579 1 None None None 116624890 Common - PAS/PAC sensor signal transduction histidine kinase Acid_5814 219 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 116624079 Common - orotate phosphoribosyltransferase Acid_4993 146 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 116619513 Common - amino acid/peptide transporter Acid_0372 82 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 116619228 Common - Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes-like protein Acid_0083 13 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 116619404 Nonpathogen - hypothetical protein Acid_0263 1 None None None 116620378 Common - NAD-dependent epimerase/dehydratase Acid_1255 216 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116620116 Common - short-chain dehydrogenase/reductase SDR Acid_0989 235 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 116626228 Common - metal dependent phosphohydrolase Acid_7188 124 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 116626583 Nonpathogen - hypothetical protein Acid_7546 1 None None None 116623695 Common - Beta-galactosidase Acid_4607 72 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 116620771 Common - Tetratricopeptide TPR_2 repeat protein Acid_1652 73 COG4995 COG4995, Uncharacterized protein conserved in bacteria Function unknown 116621206 Common - protein of unknown function DUF1080 Acid_2087 8 None None None 116623564 Nonpathogen - TonB family protein Acid_4474 2 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 116620659 Common - MutT/NUDIX family protein Acid_1539 13 None None None 116623535 Nonpathogen - hypothetical protein Acid_4445 1 None None None 116625427 Common - binding-protein-dependent transport systems inner membrane component Acid_6372 24 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 116622690 Common - UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase Acid_3589 143 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 116619522 Common - microcompartments protein Acid_0381 46 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 116619914 Nonpathogen - hypothetical protein Acid_0786 3 None None None 116620090 Nonpathogen - hypothetical protein Acid_0962 1 COG3115 ZipA, Cell division protein Cell division and chromosome partitioning 116624043 Nonpathogen - hypothetical protein Acid_4957 1 None None None 116624300 Common - hypothetical protein Acid_5218 4 None None None 116622902 Nonpathogen - hypothetical protein Acid_3803 1 None None None 116624866 Common - inositol monophosphatase Acid_5790 197 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 116626437 Common - type II secretion system protein E Acid_7399 162 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 116624707 Common - protein of unknown function DUF1634 Acid_5631 16 COG4272 COG4272, Predicted membrane protein Function unknown 116622058 Common - phage integrase family protein Acid_2945 189 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116624494 Nonpathogen - hypothetical protein Acid_5416 1 None None None 116626928 Nonpathogen - hypothetical protein Acid_7905 2 None None None 116619393 Common - 4-hydroxybenzoate 3-monooxygenase Acid_0252 56 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 116625395 Common - eight transmembrane protein EpsH Acid_6340 34 None None None 116619682 Nonpathogen - hypothetical protein Acid_0547 3 None None None 116621634 Common - hypothetical protein Acid_2516 39 None None None 116620710 Common - Tetratricopeptide TPR_4 Acid_1590 86 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116620262 Common - beta-lactamase domain protein Acid_1139 63 COG1237 COG1237, Metal-dependent hydrolases of the beta-lactamase superfamily II General function prediction only 116619336 Common - Exo-alpha-sialidase Acid_0193 19 COG4409 NanH, Neuraminidase (sialidase) Carbohydrate transport and metabolism 116624883 Common - short-chain dehydrogenase/reductase SDR Acid_5807 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116620492 Nonpathogen - hypothetical protein Acid_1370 1 None None None 116624568 Common - short-chain dehydrogenase/reductase SDR Acid_5492 237 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 116621340 Common - peptidase A24A, prepilin type IV Acid_2221 38 COG4960 CpaA, Flp pilus assembly protein, protease CpaA Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 116621947 Common - transcriptional regulator, PadR-like family Acid_2832 28 COG1695 COG1695, Predicted transcriptional regulators Transcription 116623004 Common - prevent-host-death family protein Acid_3908 41 COG2161 StbD, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 116626719 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_7691 106 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116619906 Common - Hydroxypyruvate reductase Acid_0778 86 COG2379 GckA, Putative glycerate kinase Carbohydrate transport and metabolism 116626081 Common - hypothetical protein Acid_7039 9 None None None 116625491 Common - conserved hypothetical protein, signal peptide prediction Acid_6437 4 None None None 116621530 Nonpathogen - protein of unknown function DUF1555 Acid_2412 2 None None None 116623978 Common - OmpA/MotB domain protein Acid_4890 169 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 116625747 Common - UDP-glucose 6-dehydrogenase Acid_6697 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 116620728 Common - hypothetical protein Acid_1608 16 None None None 116625817 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Acid_6768 126 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116621389 Common - hypothetical protein Acid_2270 5 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116621448 Common - plasmid maintenance system antidote protein, XRE family Acid_2330 78 COG3093 VapI, Plasmid maintenance system antidote protein General function prediction only 116622547 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_3445 13 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116622648 Common - beta-ketoacyl synthase Acid_3547 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116625498 Common - protein of unknown function UPF0182 Acid_6445 48 COG1615 COG1615, Uncharacterized conserved protein Function unknown 116624006 Common - Quinoprotein glucose dehydrogenase Acid_4918 59 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116625228 Common - Pirin domain protein domain protein Acid_6173 148 COG1741 COG1741, Pirin-related protein General function prediction only 116620652 Nonpathogen - hypothetical protein Acid_1532 1 None None None 116620713 Common - ASPIC/UnbV domain protein Acid_1593 30 COG0457 NrfG, FOG: TPR repeat General function prediction only 116623651 Common - major facilitator superfamily MFS_1 Acid_4563 185 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116622981 Common - anti-sigma-factor antagonist Acid_3884 50 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 116625551 Nonpathogen - hypothetical protein Acid_6498 1 None None None 116626518 Common - Peptidoglycan-binding domain 1 protein Acid_7481 17 None None None 116622673 Nonpathogen - hypothetical protein Acid_3572 1 None None None 116620021 Common - CRISPR-associated RAMP protein, Csm3 family Acid_0893 34 COG1337 COG1337, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 116624324 Common - ribonuclease R Acid_5242 192 COG0557 VacB, Exoribonuclease R Transcription 116624610 Common - nitrogen regulatory protein P-II Acid_5534 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 116625167 Common - peptidase M28 Acid_6111 65 COG2234 Iap, Predicted aminopeptidases General function prediction only 116625359 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Acid_6304 206 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 116622537 Nonpathogen - hypothetical protein Acid_3435 1 None None None 116622935 Nonpathogen - hypothetical protein Acid_3837 7 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 116625558 Common - MscS Mechanosensitive ion channel Acid_6505 13 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 116626272 Nonpathogen - hypothetical protein Acid_7232 1 None None None 116622271 Common - DNA polymerase III, subunits gamma and tau Acid_3165 246 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 116620614 Common - peptidase M20 Acid_1493 129 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116623968 Nonpathogen - hypothetical protein Acid_4880 1 None None None 116625574 Common - Resolvase helix-turn-helix domain protein Acid_6522 4 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 116621320 Common - PA14 domain protein Acid_2201 12 None None None 116624684 Common - Heavy metal transport/detoxification protein Acid_5608 34 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 116625500 Common - TonB-dependent receptor, plug Acid_6447 23 None None None 116620488 Common - Radical SAM domain protein Acid_1366 77 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116624142 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Acid_5058 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 116625801 Common - beta-lactamase Acid_6751 97 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116620479 Common - aminotransferase class-III Acid_1357 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 116619887 Common - peptidase S9, prolyl oligopeptidase active site domain protein Acid_0759 87 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116620787 Nonpathogen - hypothetical protein Acid_1668 1 None None None 116623911 Common - HI0933 family protein Acid_4823 137 COG2081 COG2081, Predicted flavoproteins General function prediction only 116622739 Common - Cna B domain protein Acid_3638 13 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116620252 Common - Integrase, catalytic region Acid_1129 78 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 116624183 Common - ribosomal protein L15 Acid_5099 222 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 116624215 Common - GCN5-related N-acetyltransferase Acid_5131 23 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 116622136 Nonpathogen - LmbE-like protein Acid_3024 7 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 116623050 Common - aminotransferase, class I and II Acid_3954 223 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 116622641 Nonpathogen - response regulator receiver protein Acid_3540 3 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 116626650 Common - Integrase, catalytic region Acid_7618 78 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 116620709 Common - ASPIC/UnbV domain protein Acid_1589 27 None None None 116621684 Common rplS 50S ribosomal protein L19 Acid_2566 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 116625993 Common - acriflavin resistance protein Acid_6951 186 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116624218 Nonpathogen - hypothetical protein Acid_5134 1 None None None 116621921 Nonpathogen - Xylose isomerase domain protein TIM barrel Acid_2806 13 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116625147 Common - hypothetical protein Acid_6085 23 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116622770 Common - transcriptional regulator, BadM/Rrf2 family Acid_3669 163 COG1959 COG1959, Predicted transcriptional regulator Transcription 116623602 Common - hypothetical protein Acid_4512 35 COG3247 HdeD, Uncharacterized conserved protein Function unknown 116625437 Nonpathogen - hypothetical protein Acid_6382 1 None None None 116622028 Common - hypothetical protein Acid_2913 21 None None None 116623544 Common - oxidoreductase domain protein Acid_4454 163 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116621820 Nonpathogen - hypothetical protein Acid_2702 5 None None None 116619303 Nonpathogen - amino acid-binding ACT domain protein Acid_0159 15 COG1707 COG1707, ACT domain-containing protein General function prediction only 116624396 Common - 4-alpha-glucanotransferase Acid_5317 120 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 116620931 Nonpathogen - hypothetical protein Acid_1812 1 None None None 116622899 Nonpathogen - Ferric reductase domain protein transmembrane component, N-terminal domain Acid_3800 2 COG4097 COG4097, Predicted ferric reductase Inorganic ion transport and metabolism 116624991 Common - hypothetical protein Acid_5921 24 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116621330 Common - peptidase M20 Acid_2211 169 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116620589 Common - protein of unknown function DUF214 Acid_1468 12 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116621893 Common - putative transposase Acid_2778 31 None None None 116619252 Common - thiamine biosynthesis protein ThiS Acid_0108 43 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 116623600 Nonpathogen - hypothetical protein Acid_4510 2 None None None 116624167 Common - serine/threonine protein kinase Acid_5083 142 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116621223 Common - protein of unknown function DUF303, acetylesterase putative Acid_2104 15 None None None 116620513 Common - Methyltransferase type 11 Acid_1391 39 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116625843 Nonpathogen - hypothetical protein Acid_6796 2 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 116624140 Common - Patatin Acid_5056 14 COG0392 COG0392, Predicted integral membrane protein Function unknown 116624160 Common - hypothetical protein Acid_5076 66 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 116620733 Nonpathogen - hypothetical protein Acid_1614 1 None None None 116624038 Common - Amidase Acid_4952 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 116624101 Common - NADH ubiquinone oxidoreductase, 20 kDa subunit Acid_5016 50 COG1941 FrhG, Coenzyme F420-reducing hydrogenase, gamma subunit Energy production and conversion 116624792 Common - anti-ECFsigma factor, ChrR Acid_5716 7 COG3806 ChrR, Transcriptional activator Transcription 116623286 Nonpathogen - hypothetical protein Acid_4193 2 None None None 116623617 Nonpathogen - hypothetical protein Acid_4527 1 COG2718 COG2718, Uncharacterized conserved protein Function unknown 116622629 Common - Carboxymethylenebutenolidase Acid_3528 100 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 116621829 Nonpathogen - hypothetical protein Acid_2711 1 None None None 116621023 Nonpathogen - hypothetical protein Acid_1904 1 None None None 116619284 Common - glycoside hydrolase, family 18 Acid_0140 22 COG3469 COG3469, Chitinase Carbohydrate transport and metabolism 116622314 Nonpathogen - hypothetical protein Acid_3208 3 COG4980 GvpP, Gas vesicle protein General function prediction only 116620306 Common - Quinoprotein glucose dehydrogenase Acid_1183 65 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116623051 Common - transposase IS116/IS110/IS902 family protein Acid_3955 87 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116624305 Common - putative transcriptional regulator, ArsR family Acid_5223 61 COG0640 ArsR, Predicted transcriptional regulators Transcription 116624444 Common - response regulator receiver protein Acid_5366 223 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116619281 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_0137 59 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116622132 Common - Methyltransferase type 12 Acid_3020 35 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116625738 Common - transposase IS116/IS110/IS902 family protein Acid_6688 86 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116624108 Common - hypothetical protein Acid_5023 9 None None None 116624330 Common - PA14 domain protein Acid_5248 10 None None None 116625079 Nonpathogen - hypothetical protein Acid_6010 1 None None None 116619413 Common - asparagine synthase (glutamine-hydrolyzing) Acid_0272 154 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 116622740 Common - TonB-dependent receptor Acid_3639 56 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116624587 Common - Uracil phosphoribosyltransferase Acid_5511 112 COG2065 PyrR, Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase Nucleotide transport and metabolism 116625653 Common - 40-residue YVTN family beta-propeller repeat protein Acid_6602 56 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116625378 Nonpathogen - ribosomal protein L33 Acid_6323 5 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 116619162 Common - parB-like partition protein Acid_0017 184 COG1475 Spo0J, Predicted transcriptional regulators Transcription 116621282 Common - glycosyl transferase, family 2 Acid_2163 121 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116619500 Common - Urate oxidase Acid_0359 14 COG3648 COG3648, Uricase (urate oxidase) Secondary metabolites biosynthesis, transport, and catabolism 116619734 Common - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Acid_0599 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 116619996 Common - hypothetical protein Acid_0868 52 COG3665 COG3665, Uncharacterized conserved protein Function unknown 116626702 Common - Lytic transglycosylase, catalytic Acid_7674 128 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 116620979 Common - nucleotide-binding protein Acid_1860 11 COG4271 COG4271, Predicted nucleotide-binding protein containing TIR -like domain Transcription 116623444 Common - Alg9 family protein mannosyltransferase Acid_4353 6 COG4745 COG4745, Predicted membrane-bound mannosyltransferase Posttranslational modification, protein turnover, chaperones 116622455 Common - methionyl-tRNA synthetase Acid_3353 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116621213 Common - Alpha-N-arabinofuranosidase Acid_2094 31 COG3534 AbfA, Alpha-L-arabinofuranosidase Carbohydrate transport and metabolism 116626166 Common - oxidoreductase domain protein Acid_7126 102 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116624998 Common - Succinylglutamate desuccinylase/aspartoacylase Acid_5928 50 COG3608 COG3608, Predicted deacylase General function prediction only 116623871 Common - amino acid permease-associated region Acid_4783 170 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116622745 Common - Alpha-N-arabinofuranosidase Acid_3644 33 COG3534 AbfA, Alpha-L-arabinofuranosidase Carbohydrate transport and metabolism 116624673 Nonpathogen - hypothetical protein Acid_5597 2 None None None 116625943 Nonpathogen - hypothetical protein Acid_6901 1 None None None 116625171 Common - basic membrane lipoprotein Acid_6115 79 COG1744 Med, Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein General function prediction only 116623579 Common - protein of unknown function DUF214 Acid_4489 16 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116625127 Common - hypothetical protein Acid_6064 2 COG5621 COG5621, Predicted secreted hydrolase General function prediction only 116623066 Nonpathogen - hypothetical protein Acid_3970 1 None None None 116626014 Common - hypothetical protein Acid_6972 2 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 116624173 Common - ribosomal protein L17 Acid_5089 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 116623121 Common - hypothetical protein Acid_4027 24 None None None 116622483 Common - protein of unknown function DUF1680 Acid_3381 32 COG3533 COG3533, Uncharacterized protein conserved in bacteria Function unknown 116625633 Common - major facilitator superfamily MFS_1 Acid_6582 82 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116623767 Common - transcriptional regulator, TetR family Acid_4679 22 COG1309 AcrR, Transcriptional regulator Transcription 116621052 Common - hypothetical protein Acid_1933 15 None None None 116624623 Common - conserved hypothetical protein 374 Acid_5547 31 COG0392 COG0392, Predicted integral membrane protein Function unknown 116626070 Common - Amidase Acid_7028 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 116619207 Common - urea amidolyase related protein Acid_0062 115 COG1984 DUR1, Allophanate hydrolase subunit 2 Amino acid transport and metabolism 116622727 Nonpathogen - hypothetical protein Acid_3626 1 None None None 116624799 Common - PDZ/DHR/GLGF domain protein Acid_5723 194 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 116625803 Common - response regulator receiver protein Acid_6753 21 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116623590 Nonpathogen - hypothetical protein Acid_4500 1 None None None 116621767 Common - acriflavin resistance protein Acid_2649 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116625602 Common - hydrogenase assembly chaperone hypC/hupF Acid_6551 98 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 116624056 Common - 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase Acid_4970 180 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 116620620 Common - band 7 protein Acid_1499 201 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 116622730 Common - short-chain dehydrogenase/reductase SDR Acid_3629 235 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 116620557 Common - hypothetical protein Acid_1435 51 COG5621 COG5621, Predicted secreted hydrolase General function prediction only 116621187 Common - transcriptional regulator, GntR family Acid_2068 139 COG1609 PurR, Transcriptional regulators Transcription 116620970 Common - integral membrane sensor signal transduction histidine kinase Acid_1851 222 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 116623572 Common - hypothetical protein Acid_4482 6 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 116623328 Common - cytochrome c-type biogenesis protein CcmB Acid_4237 91 COG2386 CcmB, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 116622708 Common - transcriptional regulator, PadR-like family Acid_3607 42 COG1695 COG1695, Predicted transcriptional regulators Transcription 116620014 Nonpathogen - hypothetical protein Acid_0886 1 None None None 116624787 Nonpathogen - hypothetical protein Acid_5711 3 None None None 116625718 Common - transcriptional regulator, LysR family Acid_6667 193 COG0583 LysR, Transcriptional regulator Transcription 116622102 Common - glycoside hydrolase, family 43 Acid_2989 17 COG3507 XynB, Beta-xylosidase Carbohydrate transport and metabolism 116622795 Nonpathogen - hypothetical protein Acid_3695 4 None None None 116625541 Common - hypothetical protein Acid_6488 14 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116621085 Common - hypothetical protein Acid_1966 23 None None None 116621847 Nonpathogen - hypothetical protein Acid_2729 2 None None None 116626149 Nonpathogen - glycosyl hydrolase 53 Acid_7108 1 COG3867 COG3867, Arabinogalactan endo-1,4-beta-galactosidase Carbohydrate transport and metabolism 116623501 Common - transcriptional regulator, ArsR family Acid_4411 88 COG0640 ArsR, Predicted transcriptional regulators Transcription 116619635 Common - electron transport protein SCO1/SenC Acid_0496 22 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 116626858 Common - transcriptional regulator, TetR family Acid_7833 13 COG1309 AcrR, Transcriptional regulator Transcription 116626024 Common - aspartate kinase Acid_6982 235 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 116625482 Common - CMP/dCMP deaminase, zinc-binding Acid_6428 214 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 116625682 Common - Fe-S protein, radical SAM family Acid_6631 70 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116621416 Common - SpoIID/LytB domain Acid_2298 41 COG2385 SpoIID, Sporulation protein and related proteins Cell division and chromosome partitioning 116621061 Common - NAD-dependent epimerase/dehydratase Acid_1942 26 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116622667 Common - glutamine cyclotransferase Acid_3566 22 COG3823 COG3823, Glutamine cyclotransferase Posttranslational modification, protein turnover, chaperones 116621578 Common - transposase IS3/IS911 family protein Acid_2460 51 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 116622788 Common - protein of unknown function DUF6, transmembrane Acid_3688 115 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 116626644 Nonpathogen - hypothetical protein Acid_7610 1 None None None 116620866 Common - hypothetical protein Acid_1747 139 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116619828 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_0698 166 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116619503 Common - Allantoinase Acid_0362 208 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 116623554 Common - putative esterase Acid_4464 57 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 116624273 Common - hypothetical protein Acid_5191 11 None None None 116623833 Nonpathogen - O-antigen polymerase Acid_4745 2 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 116625838 Common - phage integrase family protein Acid_6791 162 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116625904 Nonpathogen - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_6860 2 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116622703 Nonpathogen - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_3602 5 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 116621584 Common - serine/threonine protein kinase with TPR repeats Acid_2466 158 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116620952 Common - ABC transporter related Acid_1833 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 116620511 Common - TonB-dependent receptor, plug Acid_1389 21 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 116625527 Common - hypothetical protein Acid_6474 3 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 116625449 Nonpathogen - hypothetical protein Acid_6394 2 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 116622779 Common - hypothetical protein Acid_3678 14 None None None 116626370 Common - dTMP kinase Acid_7330 228 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 116626289 Nonpathogen - hypothetical protein Acid_7249 1 COG2857 CYT1, Cytochrome c1 Energy production and conversion 116623571 Common - beta-lactamase Acid_4481 86 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116622631 Common - hypothetical protein Acid_3530 48 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116624432 Common - response regulator receiver modulated serine phosphatase Acid_5354 212 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 116619801 Common - glycoside hydrolase, family 28 Acid_0671 28 COG5434 PGU1, Endopygalactorunase Cell envelope biogenesis, outer membrane 116621332 Nonpathogen - hypothetical protein Acid_2213 1 None None None 116620244 Common - hypothetical protein Acid_1121 6 None None None 116625332 Nonpathogen - hypothetical protein Acid_6277 2 None None None 116626833 Nonpathogen - hypothetical protein Acid_7806 2 None None None 116621693 Nonpathogen - hypothetical protein Acid_2575 1 None None None 116621712 Nonpathogen - hypothetical protein Acid_2594 1 None None None 116624260 Common - beta-Ig-H3/fasciclin Acid_5178 70 COG2335 COG2335, Secreted and surface protein containing fasciclin-like repeats Cell envelope biogenesis, outer membrane 116624968 Common solA N-methyltryptophan oxidase Acid_5898 91 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 116619433 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Acid_0292 1 None None None 116624005 Common - peptidase S9, prolyl oligopeptidase active site domain protein Acid_4917 73 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116619299 Nonpathogen - hypothetical protein Acid_0155 1 None None None 116622269 Common - hypothetical protein Acid_3163 55 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 116624472 Common - tRNA/rRNA methyltransferase (SpoU) Acid_5394 209 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 116619472 Common - OmpA/MotB domain protein Acid_0331 145 COG1360 MotB, Flagellar motor protein Cell motility and secretion 116619605 Common - ATP synthase F1, epsilon subunit Acid_0466 38 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 116621314 Common - response regulator receiver protein Acid_2195 216 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 116625724 Common - Deoxyribodipyrimidine photo-lyase Acid_6673 35 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 116621178 Common - protein of unknown function DUF296 Acid_2059 38 COG1661 COG1661, Predicted DNA-binding protein with PD1-like DNA-binding motif General function prediction only 116620574 Common - Altronate dehydratase Acid_1453 73 COG2721 UxaA, Altronate dehydratase Carbohydrate transport and metabolism 116625450 Common - Prolyl 4-hydroxylase, alpha subunit Acid_6395 6 COG3751 EGL-9, Predicted proline hydroxylase Posttranslational modification, protein turnover, chaperones 116625513 Nonpathogen - hypothetical protein Acid_6460 3 COG5620 COG5620, Uncharacterized conserved protein Function unknown 116621930 Common - major facilitator superfamily MFS_1 Acid_2815 84 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116625617 Common - asparagine synthetase AsnA Acid_6566 31 COG2502 AsnA, Asparagine synthetase A Amino acid transport and metabolism 116625339 Common - two component transcriptional regulator, winged helix family Acid_6284 212 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116624910 Common - putative methyltransferase Acid_5836 18 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 116619274 Common - peptidase M20 Acid_0130 176 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116623332 Common - oxidoreductase domain protein Acid_4241 103 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116626193 Common - glycosyl transferase, family 2 Acid_7153 48 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116621836 Nonpathogen - hypothetical protein Acid_2718 1 None None None 116625447 Nonpathogen - hypothetical protein Acid_6392 1 None None None 116626089 Nonpathogen - hypothetical protein Acid_7047 1 None None None 116621660 Common - beta-lactamase Acid_2542 152 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116623486 Common - Beta-galactosidase Acid_4396 39 COG1874 LacA, Beta-galactosidase Carbohydrate transport and metabolism 116619194 Nonpathogen - hypothetical protein Acid_0049 2 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 116624862 Common - protease Do Acid_5786 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 116625173 Common - hypothetical protein Acid_6117 21 None None None 116625910 Common - transposase Acid_6867 15 None None None 116621861 Nonpathogen - hypothetical protein Acid_2744 4 None None None 116622195 Common - TonB-dependent receptor Acid_3087 24 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116625594 Common - protein of unknown function DUF497 Acid_6543 22 COG2929 COG2929, Uncharacterized protein conserved in bacteria Function unknown 116622929 Nonpathogen - hypothetical protein Acid_3831 1 None None None 116619951 Common - cold-shock DNA-binding domain protein Acid_0823 182 COG1278 CspC, Cold shock proteins Transcription 116624523 Common - Hpt protein Acid_5447 2 COG2198 ArcB, FOG: HPt domain Signal transduction mechanisms 116619962 Common - uncharacterized protein involved in formate dehydrogenase formation Acid_0834 42 COG3058 FdhE, Uncharacterized protein involved in formate dehydrogenase formation Posttranslational modification, protein turnover, chaperones 116625233 Common - periplasmic binding protein/LacI transcriptional regulator Acid_6178 99 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 116619585 Common - glutaminase Acid_0446 72 COG2066 GlsA, Glutaminase Amino acid transport and metabolism 116620072 Nonpathogen - hypothetical protein Acid_0944 3 None None None 116620842 Common - ribosomal protein S20 Acid_1723 171 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 116620463 Common - GCN5-related N-acetyltransferase Acid_1341 61 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 116620664 Common - TonB-dependent receptor, plug Acid_1544 119 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116621299 Common - Methyltransferase type 11 Acid_2180 65 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116621138 Nonpathogen - hypothetical protein Acid_2019 2 None None None 116626091 Common - hypothetical protein Acid_7049 10 None None None 116619428 Common - NAD-dependent epimerase/dehydratase Acid_0287 226 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116623932 Common - Peptidyl-dipeptidase A Acid_4844 16 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 116622949 Common - imidazole glycerol phosphate synthase, glutamine amidotransferase subunit Acid_3851 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 116625001 Common - protein of unknown function DUF81 Acid_5931 114 COG0730 COG0730, Predicted permeases General function prediction only 116620980 Common - 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Acid_1861 186 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 116625153 Common - hypothetical protein Acid_6093 81 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 116623353 Common - ATPase AAA-2 domain protein Acid_4262 215 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 116624512 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Acid_5436 153 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 116619762 Nonpathogen - hypothetical protein Acid_0628 1 None None None 116619366 Common - hypothetical protein Acid_0224 33 COG3455 COG3455, Uncharacterized protein conserved in bacteria Function unknown 116625296 Common - protein of unknown function DUF214 Acid_6241 109 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620467 Common - anti-sigma-factor antagonist Acid_1345 31 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 116621868 Common - TrkA-N domain protein Acid_2751 186 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 116625357 Common - glycosyl transferase, family 2 Acid_6302 173 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 116621263 Nonpathogen - DinB family protein Acid_2144 2 COG2318 DinB, Uncharacterized protein conserved in bacteria Function unknown 116621488 Common - extracellular solute-binding protein, family 1 Acid_2370 128 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 116623679 Common - hypothetical protein Acid_4591 13 None None None 116626651 Common - IstB domain protein ATP-binding protein Acid_7619 94 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 116619453 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_0312 170 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116619692 Nonpathogen - hypothetical protein Acid_0557 1 None None None 116620855 Common - transcriptional regulator, PadR-like family Acid_1736 58 COG1695 COG1695, Predicted transcriptional regulators Transcription 116625501 Common - hypothetical protein Acid_6448 26 COG2510 COG2510, Predicted membrane protein Function unknown 116626124 Common - 6-phosphogluconate dehydrogenase Acid_7082 171 COG0362 Gnd, 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 116621162 Common - histidine kinase Acid_2043 216 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 116621707 Nonpathogen - hypothetical protein Acid_2589 1 None None None 116620183 Common - TonB-dependent receptor Acid_1056 117 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116621481 Common - transcriptional regulator, TetR family Acid_2363 133 COG1309 AcrR, Transcriptional regulator Transcription 116619205 Nonpathogen - hypothetical protein Acid_0060 5 COG4485 COG4485, Predicted membrane protein Function unknown 116621998 Common - hypothetical protein Acid_2883 24 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 116624136 Common - Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein Acid_5052 105 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116623323 Common - cytochrome c assembly protein Acid_4232 154 COG1138 CcmF, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 116623725 Nonpathogen - hypothetical protein Acid_4637 1 None None None 116621642 Nonpathogen - hypothetical protein Acid_2524 3 None None None 116623915 Nonpathogen - hypothetical protein Acid_4827 1 None None None 116624846 Common - Ig family protein Acid_5770 84 None None None 116626819 Nonpathogen - hypothetical protein Acid_7792 3 None None None 116621719 Common - transcriptional regulator, GntR family Acid_2601 209 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 116624253 Common - glycosyl transferase, group 1 Acid_5171 175 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116620344 Common - protein of unknown function DUF710 Acid_1221 8 COG3027 COG3027, Uncharacterized protein conserved in bacteria Function unknown 116624386 Common kgd alpha-ketoglutarate decarboxylase Acid_5307 194 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 116622587 Common - ASPIC/UnbV domain protein Acid_3485 29 None None None 116621770 Nonpathogen - hypothetical protein Acid_2652 1 None None None 116624022 Common - protein of unknown function UPF0118 Acid_4934 105 COG0628 PerM, Predicted permease General function prediction only 116626120 Nonpathogen - band 7 protein Acid_7078 6 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 116621087 Common - Cna B domain protein Acid_1968 23 None None None 116625533 Common - hypothetical protein Acid_6480 11 COG3595 COG3595, Uncharacterized conserved protein Function unknown 116626432 Common - glycoside hydrolase, clan GH-D Acid_7394 46 COG3345 GalA, Alpha-galactosidase Carbohydrate transport and metabolism 116626664 Nonpathogen - peptidase C14, caspase catalytic subunit p20 Acid_7633 10 COG4249 COG4249, Uncharacterized protein containing caspase domain General function prediction only 116622761 Common - peptidyl-prolyl cis-trans isomerase, cyclophilin type Acid_3660 191 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 116625298 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_6243 33 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 116624462 Nonpathogen - hypothetical protein Acid_5384 1 None None None 116619896 Nonpathogen - type IV pilus assembly PilZ Acid_0768 2 None None None 116622039 Common - protein of unknown function DUF438 Acid_2924 25 COG2461 COG2461, Uncharacterized conserved protein Function unknown 116621140 Nonpathogen - hypothetical protein Acid_2021 1 None None None 116620126 Common - kinase-like protein Acid_0999 27 COG4639 COG4639, Predicted kinase General function prediction only 116625081 Nonpathogen - hypothetical protein Acid_6012 1 None None None 116622888 Common - ATPase, BadF/BadG/BcrA/BcrD type Acid_3789 38 COG2971 COG2971, Predicted N-acetylglucosamine kinase Carbohydrate transport and metabolism 116625243 Common - cyclic nucleotide-binding protein Acid_6188 131 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 116620312 Common - Cna B domain protein Acid_1189 11 None None None 116621074 Common - putative transposase protein, Y4bF Acid_1955 20 None None None 116625083 Nonpathogen - hypothetical protein Acid_6016 1 None None None 116624069 Common - L-lactate transport Acid_4983 104 COG1620 LldP, L-lactate permease Energy production and conversion 116621515 Common - Methyltransferase type 11 Acid_2397 97 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116620322 Nonpathogen - hypothetical protein Acid_1199 1 None None None 116623942 Common - hypothetical protein Acid_4854 23 COG4313 COG4313, Protein involved in meta-pathway of phenol degradation Energy production and conversion 116619840 Nonpathogen - hypothetical protein Acid_0710 7 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 116624096 Common - glutamyl-tRNA synthetase Acid_5011 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 116621581 Common - Glucose/sorbosone dehydrogenase-like protein Acid_2463 109 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 116622580 Common - alpha/beta hydrolase fold Acid_3478 108 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 116626005 Nonpathogen - protein of unknown function UPF0153 Acid_6963 5 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 116626441 Common - succinate dehydrogenase/fumarate reductase iron-sulfur subunit Acid_7403 61 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 116619744 Nonpathogen - hypothetical protein Acid_0610 1 None None None 116624482 Common - hypothetical protein Acid_5404 18 None None None 116622604 Common - beta-lactamase domain protein Acid_3502 57 COG1237 COG1237, Metal-dependent hydrolases of the beta-lactamase superfamily II General function prediction only 116619940 Common - protein of unknown function DUF1080 Acid_0812 6 None None None 116621519 Common - Stearoyl-CoA 9-desaturase Acid_2401 70 COG1398 OLE1, Fatty-acid desaturase Lipid metabolism 116620681 Nonpathogen - hypothetical protein Acid_1561 1 None None None 116623954 Common - putative 2-phosphosulfolactate phosphatase Acid_4866 17 COG2045 COG2045, Phosphosulfolactate phosphohydrolase and related enzymes Coenzyme metabolism / General function prediction only 116622219 Common - type I phosphodiesterase/nucleotide pyrophosphatase Acid_3112 7 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 116622308 Common - alpha/beta hydrolase fold Acid_3202 63 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 116620453 Common - microcompartments protein Acid_1331 46 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 116620425 Common - hypothetical protein Acid_1302 5 None None None 116620900 Common - hypothetical protein Acid_1781 22 COG5368 COG5368, Uncharacterized protein conserved in bacteria Function unknown 116619683 Nonpathogen - O-antigen polymerase Acid_0548 10 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 116621902 Common - hypothetical protein Acid_2787 6 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116621152 Common - ankyrin Acid_2033 117 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 116626519 Common - transcriptional regulator, MerR family Acid_7482 111 COG0789 SoxR, Predicted transcriptional regulators Transcription 116623688 Nonpathogen - hypothetical protein Acid_4600 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116620213 Common - tRNA modification GTPase TrmE Acid_1088 217 COG0486 ThdF, Predicted GTPase General function prediction only 116621815 Common - DSBA oxidoreductase Acid_2697 41 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 116619523 Common - aldehyde dehydrogenase Acid_0382 183 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 116622066 Common - von Willebrand factor, type A Acid_2953 28 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 116622324 Common - thioesterase superfamily protein Acid_3218 35 COG0824 FcbC, Predicted thioesterase General function prediction only 116619702 Nonpathogen - hypothetical protein Acid_0567 1 None None None 116625746 Common - two component transcriptional regulator, winged helix family Acid_6696 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116626435 Common - RNA polymerase, sigma 54 subunit, RpoN Acid_7397 145 COG1508 RpoN, DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog Transcription 116622526 Common - carbohydrate kinase, FGGY Acid_3424 91 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 116620784 Common - vitamin B12-dependent ribonucleotide reductase Acid_1665 204 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 116623681 Common - major facilitator superfamily MFS_1 Acid_4593 122 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116626512 Common - sulfatase Acid_7475 93 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116623585 Nonpathogen - hypothetical protein Acid_4495 1 None None None 116623293 Common - iron-sulfur cluster assembly accessory protein Acid_4200 166 COG0316 IscA, Uncharacterized conserved protein Function unknown 116623187 Nonpathogen - hypothetical protein Acid_4094 5 None None None 116620895 Common - TonB-dependent receptor Acid_1776 24 None None None 116619307 Common - integral membrane protein-like protein Acid_0164 20 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 116619631 Common - conserved hypothetical protein, transmembrane prediction Acid_0492 18 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 116620531 Common - SAF domain Acid_1409 40 COG3745 CpaB, Flp pilus assembly protein CpaB Intracellular trafficking and secretion 116621973 Common - protein of unknown function DUF1697 Acid_2858 44 COG3797 COG3797, Uncharacterized protein conserved in bacteria Function unknown 116626314 Common - aminotransferase, class I and II Acid_7274 239 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 116620381 Common - methylated-DNA--protein-cysteine methyltransferase Acid_1258 195 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 116622032 Common - twin-arginine translocation pathway signal Acid_2917 46 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 116625060 Common - ABC transporter related Acid_5990 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116624697 Common - NHL repeat containing protein Acid_5621 35 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116625565 Common - sulfate adenylyltransferase, small subunit Acid_6512 134 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 116622716 Nonpathogen - hypothetical protein Acid_3615 2 None None None 116625393 Common - Ig family protein Acid_6338 5 None None None 116622090 Nonpathogen - hypothetical protein Acid_2977 2 None None None 116621939 Common - isocitrate dehydrogenase Acid_2824 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 116620809 Nonpathogen - hypothetical protein Acid_1690 1 None None None 116622769 Nonpathogen - hypothetical protein Acid_3668 1 None None None 116626618 Common - Cytochrome-c oxidase Acid_7581 173 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 116624152 Nonpathogen - hypothetical protein Acid_5068 1 COG4371 COG4371, Predicted membrane protein Function unknown 116621423 Common - transcriptional regulator, PadR-like family Acid_2305 4 COG1695 COG1695, Predicted transcriptional regulators Transcription 116626244 Common - pyruvate phosphate dikinase Acid_7204 231 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 116626178 Common - Lytic transglycosylase, catalytic Acid_7138 155 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 116619153 Common - Methyltransferase type 11 Acid_0008 181 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116619652 Common - OmpA/MotB domain protein Acid_0513 147 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 116623275 Common - hypothetical protein Acid_4182 14 COG5606 COG5606, Uncharacterized conserved small protein Function unknown 116621700 Common - transcriptional regulator, MarR family with acetyltransferase activity Acid_2582 64 COG1846 MarR, Transcriptional regulators Transcription 116621046 Common - amino acid permease-associated region Acid_1927 187 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116621259 Nonpathogen - hypothetical protein Acid_2140 2 None None None 116621461 Common - hypothetical protein Acid_2343 80 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 116623227 Common - Radical SAM domain protein Acid_4134 13 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116619296 Nonpathogen - hypothetical protein Acid_0152 2 None None None 116619710 Common - glycosyl transferase, family 2 Acid_0575 173 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116621238 Common - PAS/PAC sensor hybrid histidine kinase Acid_2119 217 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116626797 Common - glycoside hydrolase, family 28 Acid_7770 26 COG5434 PGU1, Endopygalactorunase Cell envelope biogenesis, outer membrane 116624284 Common - uroporphyrinogen decarboxylase Acid_5202 182 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 116623615 Common - transcriptional regulator, PadR-like family Acid_4525 28 COG1695 COG1695, Predicted transcriptional regulators Transcription 116624744 Common - metallophosphoesterase Acid_5668 7 COG1409 Icc, Predicted phosphohydrolases General function prediction only 116626861 Common - efflux transporter, RND family, MFP subunit Acid_7836 157 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 116624754 Common - Cupin 2, conserved barrel domain protein Acid_5678 19 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 116619945 Common - protein of unknown function DUF164 Acid_0817 41 COG1579 COG1579, Zn-ribbon protein, possibly nucleic acid-binding General function prediction only 116621437 Nonpathogen - type IV pilus assembly PilZ Acid_2319 1 None None None 116621601 Common - seryl-tRNA synthetase Acid_2483 243 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 116626253 Nonpathogen - protein of unknown function DUF214 Acid_7213 11 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116619974 Common - aldo/keto reductase Acid_0846 196 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 116625139 Nonpathogen - hypothetical protein Acid_6077 1 None None None 116621163 Common - multi-sensor signal transduction histidine kinase Acid_2044 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116625182 Nonpathogen - hypothetical protein Acid_6127 2 None None None 116626759 Common - DNA topoisomerase III Acid_7732 248 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 116626929 Common - single-strand binding protein Acid_7906 213 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 116626755 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Acid_7728 114 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116621877 Common - 5'-3' exonuclease Acid_2760 208 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 116625196 Common - protein of unknown function DUF1080 Acid_6141 10 None None None 116619345 Nonpathogen - hypothetical protein Acid_0202 1 None None None 116620204 Common - Alpha/beta hydrolase fold-3 domain protein Acid_1077 145 COG0657 Aes, Esterase/lipase Lipid metabolism 116621026 Nonpathogen - hypothetical protein Acid_1907 1 None None None 116623506 Common - glycoside hydrolase, family 31 Acid_4416 53 COG1501 COG1501, Alpha-glucosidases, family 31 of glycosyl hydrolases Carbohydrate transport and metabolism 116626848 Common - competence protein ComEA helix-hairpin-helix repeat protein Acid_7821 15 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 116626850 Nonpathogen - hypothetical protein Acid_7823 3 None None None 116619490 Common - amine oxidase Acid_0349 65 COG1232 HemY, Protoporphyrinogen oxidase Coenzyme metabolism 116626538 Nonpathogen - hypothetical protein Acid_7501 1 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 116624479 Common - GCN5-related N-acetyltransferase Acid_5401 14 COG0456 RimI, Acetyltransferases General function prediction only 116624445 Common - putative chemotaxis protein CheX Acid_5367 18 COG1406 COG1406, Predicted inhibitor of MCP methylation, homolog of CheC Cell motility and secretion 116619757 Common - methyltransferase FkbM family Acid_0623 63 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116625025 Common - oxidoreductase domain protein Acid_5955 143 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116619724 Common - hypothetical protein Acid_0589 4 None None None 116623703 Common - major facilitator superfamily MFS_1 Acid_4615 82 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116619579 Nonpathogen - hypothetical protein Acid_0440 1 None None None 116626044 Common - histidine kinase internal region Acid_7002 103 COG2972 COG2972, Predicted signal transduction protein with a C-terminal ATPase domain Signal transduction mechanisms 116624427 Common - hypothetical protein Acid_5349 17 COG1554 ATH1, Trehalose and maltose hydrolases (possible phosphorylases) Carbohydrate transport and metabolism 116622705 Nonpathogen - hypothetical protein Acid_3604 6 None None None 116621592 Common - peptidase dimerisation domain protein Acid_2474 24 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116621528 Common - Radical SAM domain protein Acid_2410 83 COG1964 COG1964, Predicted Fe-S oxidoreductases General function prediction only 116626672 Common - phage integrase family protein Acid_7641 217 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116626419 Nonpathogen - hypothetical protein Acid_7381 1 None None None 116622549 Common - hypothetical protein Acid_3447 41 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116619508 Common - hypothetical protein Acid_0367 3 None None None 116622799 Common - Membrane dipeptidase Acid_3699 100 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 116622484 Nonpathogen - hypothetical protein Acid_3382 1 None None None 116622103 Common - Acetyl xylan esterase Acid_2990 19 COG3458 COG3458, Acetyl esterase (deacetylase) Secondary metabolites biosynthesis, transport, and catabolism 116623048 Common - protein of unknown function DUF1549 Acid_3952 9 None None None 116624899 Common - pseudouridine synthase, RluA family Acid_5824 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 116622995 Common - transcriptional regulator, BadM/Rrf2 family Acid_3899 175 COG1959 COG1959, Predicted transcriptional regulator Transcription 116619882 Common - N-acyl-D-amino-acid deacylase Acid_0754 56 COG3653 COG3653, N-acyl-D-aspartate/D-glutamate deacylase Secondary metabolites biosynthesis, transport, and catabolism 116620011 Common - TonB-dependent receptor Acid_0883 27 COG4932 COG4932, Predicted outer membrane protein Cell envelope biogenesis, outer membrane 116624633 Common - cell surface receptor IPT/TIG domain protein Acid_5557 13 COG5492 COG5492, Bacterial surface proteins containing Ig-like domains Cell motility and secretion 116626591 Common - multi-sensor signal transduction histidine kinase Acid_7554 220 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 116619313 Nonpathogen - hypothetical protein Acid_0170 1 None None None 116624977 Common - aldo/keto reductase Acid_5907 17 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116623943 Common - lipopolysaccharide biosynthesis Acid_4855 170 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 116623036 Nonpathogen - hypothetical protein Acid_3940 1 None None None 116626101 Common - LAO/AO transport system ATPase Acid_7059 122 COG1703 ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family Amino acid transport and metabolism 116621775 Nonpathogen - Redoxin domain protein Acid_2657 3 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 116623480 Common - Membrane dipeptidase Acid_4390 103 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 116626036 Common - TonB-dependent receptor, plug Acid_6994 22 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116622261 Common - transposase IS3/IS911 family protein Acid_3155 51 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 116623109 Nonpathogen - hypothetical protein Acid_4013 2 None None None 116622154 Common - Carboxymethylenebutenolidase Acid_3046 112 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 116626319 Nonpathogen - hypothetical protein Acid_7279 1 None None None 116619237 Common - Carboxylesterase, type B Acid_0092 68 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 116624072 Nonpathogen - hypothetical protein Acid_4986 2 None None None 116623624 Nonpathogen - hypothetical protein Acid_4534 1 None None None 116621302 Common - protein of unknown function DUF214 Acid_2183 77 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116626859 Common - RND efflux system, outer membrane lipoprotein, NodT family Acid_7834 127 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116624582 Common - ribonuclease T2 Acid_5506 41 COG3719 Rna, Ribonuclease I Translation, ribosomal structure and biogenesis 116622407 Common - 4-oxalocrotonate tautomerase Acid_3302 16 COG1942 COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog General function prediction only 116626810 Nonpathogen - hypothetical protein Acid_7783 1 COG4795 PulJ, Type II secretory pathway, component PulJ Intracellular trafficking and secretion 116619302 Common - hypothetical protein Acid_0158 30 COG4278 COG4278, Uncharacterized conserved protein Function unknown 116622334 Nonpathogen - hypothetical protein Acid_3228 3 None None None 116622437 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_3335 59 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 116619499 Common - hypothetical protein Acid_0358 56 COG3195 COG3195, Uncharacterized protein conserved in bacteria Function unknown 116622660 Nonpathogen - protein of unknown function DUF214 Acid_3559 10 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620695 Common - hypothetical protein Acid_1575 10 COG3934 COG3934, Endo-beta-mannanase Carbohydrate transport and metabolism 116626463 Common murQ N-acetylmuramic acid-6-phosphate etherase Acid_7426 87 COG2103 COG2103, Predicted sugar phosphate isomerase General function prediction only 116626829 Common - short-chain dehydrogenase/reductase SDR Acid_7802 229 COG0623 FabI, Enoyl- acyl-carrier-protein 116624456 Common - aminotransferase, class I and II Acid_5378 237 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 116619923 Common - hypothetical protein Acid_0795 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 116620540 Nonpathogen - hypothetical protein Acid_1418 2 None None None 116622628 Common - protein of unknown function DUF214 Acid_3527 127 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620187 Common - type II and III secretion system protein Acid_1060 135 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 116626038 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Acid_6996 122 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 116624053 Common - hypothetical protein Acid_4967 24 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116626902 Common - histidine kinase Acid_7879 148 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 116621351 Nonpathogen - hypothetical protein Acid_2232 1 None None None 116620333 Common - Ankyrin Acid_1210 107 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 116620965 Common - GCN5-related N-acetyltransferase Acid_1846 14 COG3375 COG3375, Uncharacterized conserved protein Function unknown 116622988 Common - amidohydrolase Acid_3891 114 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116624683 Common - acetyltransferase, GNAT family Acid_5607 7 None None None 116625009 Common - glycosyl transferase, family 39 Acid_5939 20 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116621455 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding Acid_2337 14 COG3787 COG3787, Uncharacterized protein conserved in bacteria Function unknown 116624203 Common - ribosomal protein S10 Acid_5119 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 116622125 Common - glycosyl transferase, group 1 Acid_3013 99 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116622043 Common - molybdopterin oxidoreductase Acid_2928 189 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 116625767 Common - D-tyrosyl-tRNA(Tyr) deacylase Acid_6717 139 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 116620704 Common - Sua5/YciO/YrdC/YwlC family protein Acid_1584 237 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 116622557 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_3455 92 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116625685 Common - glycosyl transferase, group 1 Acid_6634 117 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116625109 Common - FkbH like protein Acid_6045 31 COG3882 FkbH, Predicted enzyme involved in methoxymalonyl-ACP biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 116624618 Common - Inorganic diphosphatase Acid_5542 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 116622023 Common - aldo/keto reductase Acid_2908 192 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116623131 Common - phospholipase D/Transphosphatidylase Acid_4037 4 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 116623359 Common - protein of unknown function DUF214 Acid_4268 101 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623116 Common - alpha/beta hydrolase fold Acid_4021 170 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 116624728 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_5652 164 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 116619489 Common - MATE efflux family protein Acid_0348 173 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 116623983 Nonpathogen - hypothetical protein Acid_4895 1 None None None 116620303 Common - hypothetical protein Acid_1180 23 None None None 116619836 Nonpathogen - hypothetical protein Acid_0706 2 None None None 116621647 Common - IS66 Orf2 family protein Acid_2529 52 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 116623304 Nonpathogen - hypothetical protein Acid_4211 1 None None None 116622144 Common - transcriptional regulator, ArsR family Acid_3036 86 COG1777 COG1777, Predicted transcriptional regulators Transcription 116622113 Nonpathogen - hypothetical protein Acid_3001 1 None None None 116626481 Common - AMP-dependent synthetase and ligase Acid_7444 215 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 116624669 Common - caa(3)-type oxidase, subunit IV Acid_5593 6 COG5605 COG5605, Predicted small integral membrane protein Function unknown 116620196 Common - methyl-accepting chemotaxis sensory transducer Acid_1069 77 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 116620939 Common - major facilitator superfamily MFS_1 Acid_1820 174 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116619351 Common - hypothetical protein Acid_0209 6 COG4285 COG4285, Uncharacterized conserved protein Function unknown 116624468 Common - cation diffusion facilitator family transporter Acid_5390 212 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 116626682 Common - Cupin 2, conserved barrel domain protein Acid_7653 28 COG4101 COG4101, Predicted mannose-6-phosphate isomerase Carbohydrate transport and metabolism 116620440 Nonpathogen - hypothetical protein Acid_1318 1 None None None 116626918 Nonpathogen - hypothetical protein Acid_7895 2 None None None 116623455 Common - UDP-N-acetylglucosamine diphosphorylase Acid_4364 235 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 116621958 Common - anti-sigma-factor antagonist Acid_2843 60 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 116624823 Nonpathogen - hypothetical protein Acid_5747 1 None None None 116622515 Common - two component, sigma54 specific, transcriptional regulator, Fis family Acid_3413 223 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116625319 Nonpathogen - hypothetical protein Acid_6264 9 COG4274 COG4274, Uncharacterized conserved protein Function unknown 116620588 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_1467 75 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116622621 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_3520 122 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116626134 Common - ribosomal protein S18 Acid_7092 214 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 116619225 Common - ABC-2 type transporter Acid_0080 156 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116620941 Common - amino acid permease-associated region Acid_1822 185 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116622652 Common - transcriptional regulator, TetR family Acid_3551 116 COG1309 AcrR, Transcriptional regulator Transcription 116620919 Nonpathogen - hypothetical protein Acid_1800 2 None None None 116622884 Common - hypothetical protein Acid_3785 9 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 116624438 Nonpathogen - hypothetical protein Acid_5360 1 None None None 116620581 Common - hypothetical protein Acid_1460 6 None None None 116620379 Nonpathogen - hypothetical protein Acid_1256 1 None None None 116619913 Common - beta-lactamase domain protein Acid_0785 109 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 116621358 Common - methyltransferase FkbM family Acid_2239 25 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116619467 Common - carbon storage regulator, CsrA Acid_0326 6 COG1551 CsrA, Carbon storage regulator (could also regulate swarming and quorum sensing) Signal transduction mechanisms 116620562 Nonpathogen - hypothetical protein Acid_1440 1 None None None 116622332 Common - Cupin 2, conserved barrel domain protein Acid_3226 4 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 116623219 Common - protein of unknown function DUF214 Acid_4126 192 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116624279 Common - transcriptional regulator, AraC family Acid_5197 130 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 116626951 Common - Alcohol dehydrogenase GroES domain protein Acid_7928 212 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 116622210 Common - citrate synthase Acid_3102 186 COG0372 GltA, Citrate synthase Energy production and conversion 116625435 Common - serine/threonine protein kinase Acid_6380 112 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116626691 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Acid_7663 196 COG0388 COG0388, Predicted amidohydrolase General function prediction only 116626330 Nonpathogen - putative transmembrane anti-sigma factor Acid_7290 3 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 116620543 Nonpathogen - glycosyl transferase, family 39 Acid_1421 3 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116623596 Nonpathogen - hypothetical protein Acid_4506 1 None None None 116625401 Nonpathogen - hypothetical protein Acid_6346 1 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116625812 Nonpathogen - hypothetical protein Acid_6763 1 None None None 116622972 Common - Propionyl-CoA carboxylase Acid_3875 148 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 116621965 Nonpathogen - hypothetical protein Acid_2850 1 None None None 116622565 Common - DNA-formamidopyrimidine glycosylase Acid_3463 179 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 116621292 Common - hypothetical protein Acid_2173 4 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116625187 Common - Hydroxymethylglutaryl-CoA reductase (NADPH) Acid_6132 41 COG1257 HMG1, Hydroxymethylglutaryl-CoA reductase Lipid metabolism 116625272 Common - von Willebrand factor, type A Acid_6217 56 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 116620211 Common - phosphate acetyltransferase Acid_1084 156 COG0280 Pta, Phosphotransacetylase Energy production and conversion 116625494 Nonpathogen - hypothetical protein Acid_6441 1 None None None 116623013 Common - beta-lactamase domain protein Acid_3917 102 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 116620948 Common - Cna B domain protein Acid_1829 22 None None None 116620191 Common - Fibronectin, type III domain protein Acid_1064 11 COG3401 COG3401, Fibronectin type 3 domain-containing protein General function prediction only 116622019 Common - NHL repeat containing protein Acid_2904 101 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 116624970 Common - hypothetical protein Acid_5900 49 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116623773 Common - Ig family protein Acid_4685 102 None None None 116626456 Common - transcriptional repressor, CopY family Acid_7418 43 COG3682 COG3682, Predicted transcriptional regulator Transcription 116620628 Common - aldo/keto reductase Acid_1507 205 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116625015 Common - amidophosphoribosyltransferase Acid_5945 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 116625704 Common - multi-sensor signal transduction histidine kinase Acid_6653 225 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 116626408 Common - hypothetical protein Acid_7370 26 COG2319 COG2319, FOG: WD40 repeat General function prediction only 116623555 Common - transposase IS116/IS110/IS902 family protein Acid_4465 82 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116622696 Nonpathogen - DinB family protein Acid_3595 3 COG2318 DinB, Uncharacterized protein conserved in bacteria Function unknown 116625820 Common - Demethylmenaquinone methyltransferase-like protein Acid_6771 51 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 116626727 Common - cysteine desulfurase activator complex subunit SufB Acid_7699 185 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 116619572 Common - glycosyl transferase, family 39 Acid_0433 30 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116626866 Common - hypothetical protein Acid_7841 22 None None None 116626391 Common - two component, sigma54 specific, transcriptional regulator, Fis family Acid_7351 202 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116622914 Common - glutamate synthases, NADH/NADPH, small subunit Acid_3815 199 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 116624662 Nonpathogen - hypothetical protein Acid_5586 2 None None None 116626656 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_7625 16 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116623477 Common - Cytochrome b/b6, N-terminal domain Acid_4387 147 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 116619188 Common - outer membrane lipoprotein carrier protein LolA Acid_0043 53 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 116622340 Common - transcriptional regulator, PadR-like family Acid_3234 54 COG1695 COG1695, Predicted transcriptional regulators Transcription 116625034 Nonpathogen - hypothetical protein Acid_5964 1 None None None 116626750 Common - ribonuclease PH Acid_7723 187 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 116624209 Common - response regulator receiver protein Acid_5125 211 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116626156 Common - Sua5/YciO/YrdC/YwlC family protein Acid_7116 238 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 116626182 Common - flagellar hook-associated protein 3 Acid_7142 50 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 116624044 Common - peptidase S1 and S6, chymotrypsin/Hap Acid_4958 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 116620396 Common - integral membrane sensor signal transduction histidine kinase Acid_1273 116 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 116623102 Common - sulfatase Acid_4006 85 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116625791 Common - putative esterase Acid_6741 27 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 116622054 Common - IS66 Orf2 family protein Acid_2940 47 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 116623192 Common - Sporulation domain protein Acid_4099 5 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 116626479 Common - glycosyl transferase, family 2 Acid_7442 203 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 116625062 Common - ABC-2 type transporter Acid_5992 170 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 116623639 Common - hypothetical protein Acid_4551 15 COG2510 COG2510, Predicted membrane protein Function unknown 116623975 Common - outer membrane efflux protein Acid_4887 46 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116622249 Common - NADP oxidoreductase, coenzyme F420-dependent Acid_3142 74 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 116621208 Common - lipolytic enzyme, G-D-S-L family Acid_2089 22 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116624638 Common - protein of unknown function DUF1501 Acid_5562 48 COG4102 COG4102, Uncharacterized protein conserved in bacteria Function unknown 116621106 Nonpathogen - hypothetical protein Acid_1987 5 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 116623513 Common - beta-lactamase domain protein Acid_4423 69 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 116626361 Nonpathogen - Ig domain protein, group 1 domain protein Acid_7321 2 None None None 116620299 Nonpathogen - hypothetical protein Acid_1176 1 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 116622179 Common - cytochrome c, class I Acid_3071 10 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 116624360 Common - glucose-6-phosphate 1-dehydrogenase Acid_5281 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 116623608 Nonpathogen - hypothetical protein Acid_4518 7 None None None 116621859 Common - Tetratricopeptide TPR_2 repeat protein Acid_2742 101 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116623799 Common - oxidoreductase domain protein Acid_4711 159 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116621098 Common - short-chain dehydrogenase/reductase SDR Acid_1979 238 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 116622639 Common - 1-pyrroline-5-carboxylate dehydrogenase Acid_3538 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 116620538 Nonpathogen - hypothetical protein Acid_1416 1 None None None 116622206 Common - hypothetical protein Acid_3098 8 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 116624534 Common - ribosomal protein L7/L12 Acid_5458 215 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 116626273 Common - transposase IS116/IS110/IS902 family protein Acid_7233 87 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116625489 Common - ATPase associated with various cellular activities, AAA_3 Acid_6435 175 COG0714 COG0714, MoxR-like ATPases General function prediction only 116625368 Common - metal dependent phosphohydrolase Acid_6313 63 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 116626550 Common - efflux transporter, RND family, MFP subunit Acid_7513 161 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 116622845 Common - protein of unknown function DUF1501 Acid_3745 5 None None None 116623144 Common - peptidase-like protein Acid_4050 36 COG4099 COG4099, Predicted peptidase General function prediction only 116626801 Nonpathogen - hypothetical protein Acid_7774 1 None None None 116619768 Common - Integrase, catalytic region Acid_0635 153 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116624118 Common - beta-lactamase Acid_5034 150 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116621475 Common - protein of unknown function DUF343 Acid_2357 38 COG2835 COG2835, Uncharacterized conserved protein Function unknown 116622175 Nonpathogen - amidohydrolase 2 Acid_3067 1 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 116623792 Common - Malate dehydrogenase Acid_4704 67 COG2055 COG2055, Malate/L-lactate dehydrogenases Energy production and conversion 116625624 Nonpathogen - hypothetical protein Acid_6573 1 None None None 116623827 Common - Diphosphate--fructose-6-phosphate 1-phosphotransferase Acid_4739 149 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 116626704 Common - peptidase M28 Acid_7676 49 COG2234 Iap, Predicted aminopeptidases General function prediction only 116622005 Common - histidine kinase Acid_2890 214 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116620626 Nonpathogen - hypothetical protein Acid_1505 2 None None None 116619530 Common - hypothetical protein Acid_0389 45 COG3395 COG3395, Uncharacterized protein conserved in bacteria Function unknown 116623696 Common - glycosidase, PH1107-related Acid_4608 26 COG2152 COG2152, Predicted glycosylase Carbohydrate transport and metabolism 116624014 Common - Alcohol dehydrogenase GroES domain protein Acid_4926 193 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 116620731 Nonpathogen - hypothetical protein Acid_1612 2 None None None 116624842 Common - peptidase M50 Acid_5766 83 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 116624144 Common - protein involved in MetA-pathway of phenol degradation Acid_5060 18 COG4313 COG4313, Protein involved in meta-pathway of phenol degradation Energy production and conversion 116623641 Common - Mannose-1-phosphate guanylyltransferase (GDP) Acid_4553 162 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 116622597 Common - hypothetical protein Acid_3495 14 None None None 116625476 Common - transcriptional regulator, MarR family Acid_6422 79 COG1846 MarR, Transcriptional regulators Transcription 116623471 Common - ABC transporter related Acid_4381 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116620223 Common - membrane bound O-acyl transferase, MBOAT family protein Acid_1100 86 COG1696 DltB, Predicted membrane protein involved in D-alanine export Cell envelope biogenesis, outer membrane 116623074 Common - major facilitator superfamily MFS_1 Acid_3978 187 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116624355 Common - protein of unknown function DUF1486 Acid_5275 16 COG5485 COG5485, Predicted ester cyclase General function prediction only 116620052 Common - protein of unknown function DUF485 Acid_0924 24 COG3162 COG3162, Predicted membrane protein Function unknown 116620590 Nonpathogen - hypothetical protein Acid_1469 1 None None None 116619255 Common - NADH dehydrogenase I, D subunit Acid_0111 192 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 116624085 Common - peptidase S9B, dipeptidylpeptidase IV domain protein Acid_4999 144 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116622534 Common - serine phosphatase Acid_3432 121 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 116621611 Common - TPR repeat protein Acid_2493 26 None None None 116624557 Common - hypothetical protein Acid_5481 5 COG3514 COG3514, Uncharacterized protein conserved in bacteria Function unknown 116620372 Common - Pectinesterase Acid_1249 17 COG4677 PemB, Pectin methylesterase Carbohydrate transport and metabolism 116624795 Nonpathogen - hypothetical protein Acid_5719 1 None None None 116626716 Nonpathogen - hypothetical protein Acid_7688 1 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 116622417 Common - phage integrase family protein Acid_3313 203 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116625492 Common - hypothetical protein Acid_6438 45 COG5426 COG5426, Uncharacterized membrane protein Function unknown 116623862 Nonpathogen - hypothetical protein Acid_4774 3 None None None 116624181 Common - adenylate kinase Acid_5097 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 116621801 Common - two component transcriptional regulator, LuxR family Acid_2683 219 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116624515 Nonpathogen - hypothetical protein Acid_5439 1 None None None 116620676 Common - Porphyromonas-type peptidyl-arginine deiminase Acid_1556 88 COG2957 COG2957, Peptidylarginine deiminase and related enzymes Amino acid transport and metabolism 116623235 Common - putative endo-1,4-beta-xylanase B Acid_4142 36 COG0657 Aes, Esterase/lipase Lipid metabolism 116619175 Common - UvrD/REP helicase Acid_0030 222 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 116621572 Common - serine/threonine protein kinase Acid_2454 150 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116626380 Common - ATP-dependent protease peptidase subunit Acid_7340 149 COG5405 HslV, ATP-dependent protease HslVU (ClpYQ), peptidase subunit Posttranslational modification, protein turnover, chaperones 116622082 Common - transcriptional regulator, Fis family Acid_2969 190 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 116619796 Common - 2-dehydropantoate 2-reductase Acid_0666 86 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 116620752 Common - hypothetical protein Acid_1633 3 None None None 116625678 Common - Methyltransferase type 11 Acid_6627 25 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116623068 Nonpathogen - hypothetical protein Acid_3972 1 None None None 116620308 Common - protein of unknown function DUF480 Acid_1185 41 COG3132 COG3132, Uncharacterized protein conserved in bacteria Function unknown 116625705 Common - hypothetical protein Acid_6654 34 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116623412 Common - integral membrane sensor signal transduction histidine kinase Acid_4321 221 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 116622674 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Acid_3573 4 COG4105 ComL, DNA uptake lipoprotein General function prediction only 116620723 Common - two component transcriptional regulator, LuxR family Acid_1603 222 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116620972 Common - PHP C-terminal domain protein Acid_1853 40 COG4464 CapC, Capsular polysaccharide biosynthesis protein Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116620111 Common - protein of unknown function DUF214 Acid_0984 49 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116621827 Nonpathogen - hypothetical protein Acid_2709 2 None None None 116625281 Common - Nucleotidyl transferase Acid_6226 233 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 116626631 Nonpathogen - TadE family protein Acid_7596 1 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 116624629 Common - peptidase M56, BlaR1 Acid_5553 19 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 116624794 Nonpathogen - hypothetical protein Acid_5718 1 None None None 116624993 Common - aldo/keto reductase Acid_5923 205 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116625804 Nonpathogen - hypothetical protein Acid_6754 2 COG4371 COG4371, Predicted membrane protein Function unknown 116625032 Common - transcriptional regulator, PadR-like family Acid_5962 58 COG1695 COG1695, Predicted transcriptional regulators Transcription 116623676 Common - formate dehydrogenase accessory protein FdhD Acid_4588 89 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 116626569 Common - hypothetical protein Acid_7532 10 COG3861 COG3861, Uncharacterized protein conserved in bacteria Function unknown 116621789 Common - ferredoxin Acid_2671 36 COG3894 COG3894, Uncharacterized metal-binding protein General function prediction only 116624545 Common - glycosyl hydrolase, BNR repeat-containing protein Acid_5469 36 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116625419 Common - hypothetical protein Acid_6364 38 None None None 116624175 Common - ribosomal protein S4 Acid_5091 240 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 116625736 Common - Ppx/GppA phosphatase Acid_6686 182 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 116623711 Common - hypothetical protein Acid_4623 38 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116621844 Nonpathogen - hypothetical protein Acid_2726 2 None None None 116621685 Common - TonB-dependent receptor Acid_2567 26 None None None 116625874 Common - response regulator receiver protein Acid_6828 24 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116619905 Common - Shikimate kinase Acid_0777 198 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 116626615 Common - glucose-methanol-choline oxidoreductase Acid_7578 92 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 116623730 Nonpathogen - Methyltransferase type 12 Acid_4642 1 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116620013 Common - glycosyltransferase 36 Acid_0885 47 COG3459 COG3459, Cellobiose phosphorylase Carbohydrate transport and metabolism 116621431 Nonpathogen - hypothetical protein Acid_2313 1 None None None 116622235 Common - hypothetical protein Acid_3128 9 None None None 116623059 Common - hypothetical protein Acid_3963 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116624399 Common - transposase IS116/IS110/IS902 family protein Acid_5320 87 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116626299 Common - Aldose 1-epimerase Acid_7259 58 COG0676 COG0676, Uncharacterized enzymes related to aldose 1-epimerase Carbohydrate transport and metabolism 116620529 Nonpathogen - hypothetical protein Acid_1407 1 None None None 116622942 Common - galactokinase Acid_3844 85 COG0153 GalK, Galactokinase Carbohydrate transport and metabolism 116622130 Nonpathogen - hypothetical protein Acid_3018 12 COG4641 COG4641, Uncharacterized protein conserved in bacteria Function unknown 116620992 Nonpathogen - hypothetical protein Acid_1873 7 None None None 116619649 Common - Biopolymer transport protein ExbD/TolR Acid_0510 100 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 116621312 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_2193 163 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116622720 Common - DSBA oxidoreductase Acid_3619 113 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 116622079 Common - ribonuclease BN Acid_2966 86 COG1295 Rbn, Predicted membrane protein Function unknown 116619537 Common - Cupin 2, conserved barrel domain protein Acid_0396 4 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 116622939 Common - serine/threonine protein kinase Acid_3841 142 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116623057 Nonpathogen - hypothetical protein Acid_3961 4 None None None 116623966 Nonpathogen - hypothetical protein Acid_4878 4 None None None 116626075 Common - Zn-dependent hydrolase of the beta-lactamase fold-like protein Acid_7033 29 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 116620881 Common - peptidase S10, serine carboxypeptidase Acid_1762 4 COG2939 COG2939, Carboxypeptidase C (cathepsin A) Amino acid transport and metabolism 116622934 Common - glycosyl transferase, family 2 Acid_3836 56 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116624489 Common - phospholipid/glycerol acyltransferase Acid_5411 196 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 116622965 Common - integral membrane protein Acid_3868 13 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 116625247 Nonpathogen - hypothetical protein Acid_6192 8 None None None 116624303 Nonpathogen - phosphodiesterase/alkaline phosphatase D Acid_5221 3 None None None 116625604 Common - phosphoheptose isomerase Acid_6553 121 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 116626016 Nonpathogen - hypothetical protein Acid_6974 2 None None None 116621505 Common - major facilitator superfamily MFS_1 Acid_2387 121 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116620822 Common - hypothetical protein Acid_1703 35 None None None 116624893 Common - hypothetical protein Acid_5817 8 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 116621652 Nonpathogen - hypothetical protein Acid_2534 3 None None None 116626852 Common - inner-membrane translocator Acid_7825 118 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 116622778 Common - oxidoreductase domain protein Acid_3677 152 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116625715 Common - major facilitator superfamily MFS_1 Acid_6664 206 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116625967 Common - nickel-dependent hydrogenase, membrane protein Acid_6925 30 COG5557 COG5557, Polysulphide reductase Energy production and conversion 116619915 Common - hypothetical protein Acid_0787 4 None None None 116625540 Common - Multidrug resistance efflux pump-like protein Acid_6487 162 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116620093 Common - regulatory protein RecX Acid_0965 75 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 116624031 Common - amino acid permease-associated region Acid_4943 175 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116624805 Nonpathogen - protein of unknown function DUF214 Acid_5729 7 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 116621066 Common - Xylose isomerase domain protein TIM barrel Acid_1947 25 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116619368 Nonpathogen - hypothetical protein Acid_0226 1 None None None 116622773 Common - Ig domain protein, group 1 domain protein Acid_3672 25 None None None 116623873 Nonpathogen - hypothetical protein Acid_4785 2 None None None 116621120 Common - phosphoribosylglycinamide formyltransferase protein Acid_2001 7 COG2315 MmcQ, Uncharacterized protein conserved in bacteria Function unknown 116621904 Common - Endothelin-converting enzyme 1 Acid_2789 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 116620888 Nonpathogen - hypothetical protein Acid_1769 1 None None None 116623992 Common - adenylate/guanylate cyclase Acid_4904 78 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 116626275 Common - transcriptional regulator, LysR family Acid_7235 192 COG0583 LysR, Transcriptional regulator Transcription 116621274 Common - hypothetical protein Acid_2155 7 None None None 116625074 Common - alpha/beta hydrolase fold Acid_6005 171 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 116625421 Nonpathogen - hypothetical protein Acid_6366 1 None None None 116623154 Common - protein of unknown function DUF1501 Acid_4060 5 COG4102 COG4102, Uncharacterized protein conserved in bacteria Function unknown 116621055 Common - Transketolase domain protein Acid_1936 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 116624925 Nonpathogen - CopG domain protein DNA-binding domain protein Acid_5852 2 None None None 116625072 Nonpathogen - Cupin 2, conserved barrel domain protein Acid_6002 5 COG3837 COG3837, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 116625126 Nonpathogen - type IV pilus assembly PilZ Acid_6063 1 None None None 116626329 Common - Ig family protein Acid_7289 41 None None None 116623786 Common - Gamma-glutamyltransferase Acid_4698 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 116624839 Common - protein of unknown function DUF224, cysteine-rich region domain protein Acid_5763 167 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 116620261 Nonpathogen - peptidase M15B and M15C, D,D-carboxypeptidase VanY/endolysins Acid_1138 1 None None None 116620726 Nonpathogen - protein of unknown function DUF1634 Acid_1606 1 COG4272 COG4272, Predicted membrane protein Function unknown 116625278 Common - Riboflavin synthase Acid_6223 230 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 116619755 Common - NAD+ synthetase Acid_0621 208 COG0171 NadE, NAD synthase Coenzyme metabolism 116624588 Common - aspartate carbamoyltransferase Acid_5512 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 116621832 Common - Hpt protein Acid_2714 10 COG2198 ArcB, FOG: HPt domain Signal transduction mechanisms 116619280 Common - glycosyl transferase, family 2 Acid_0136 116 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 116624149 Common - cell divisionFtsK/SpoIIIE Acid_5065 199 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 116621050 Nonpathogen - hypothetical protein Acid_1931 3 None None None 116624685 Common - heavy metal translocating P-type ATPase Acid_5609 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 116622563 Common - putative cell-cycle regulation histidine triad protein Acid_3461 34 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 116624531 Common - protein of unknown function DUF820 Acid_5455 6 COG4636 Uma2, Uncharacterized protein conserved in cyanobacteria Function unknown 116625940 Common - transposase, IS204/IS1001/IS1096/IS1165 family protein Acid_6898 58 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 116621203 Common - Carboxylesterase, type B Acid_2084 62 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 116624100 Common - nickel-dependent hydrogenase, large subunit Acid_5015 107 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 116624503 Nonpathogen - cyclic nucleotide-binding protein Acid_5427 17 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 116619381 Common - ATPase AAA-2 domain protein Acid_0239 215 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 116619884 Common - thiamineS protein Acid_0756 43 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 116620958 Common - riboflavin biosynthesis protein RibF Acid_1839 211 COG0196 RibF, FAD synthase Coenzyme metabolism 116623504 Common - protein of unknown function DUF167 Acid_4414 79 COG1872 COG1872, Uncharacterized conserved protein Function unknown 116625327 Nonpathogen - hypothetical protein Acid_6272 1 None None None 116621915 Common - arginase Acid_2800 153 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 116626347 Common - cell division protein FtsZ Acid_7307 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 116625536 Common - outer membrane efflux protein Acid_6483 22 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116620860 Nonpathogen - cytochrome c, class I Acid_1741 1 COG3258 COG3258, Cytochrome c Energy production and conversion 116621446 Nonpathogen - hypothetical protein Acid_2328 1 None None None 116622953 Common - Histidinol dehydrogenase Acid_3855 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 116619335 Common - dihydrodipicolinate synthetase Acid_0192 139 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 116624786 Common - WD-40 repeat protein Acid_5710 62 COG2319 COG2319, FOG: WD40 repeat General function prediction only 116622457 Common - PAS/PAC sensor signal transduction histidine kinase Acid_3355 222 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 116622755 Common - short-chain dehydrogenase/reductase SDR Acid_3654 223 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116623632 Nonpathogen - hypothetical protein Acid_4544 1 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 116624381 Common - peptidase S9B, dipeptidylpeptidase IV domain protein Acid_5302 106 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116625671 Common - glycosyl transferase, group 1 Acid_6620 31 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116626055 Common - aminodeoxychorismate lyase Acid_7013 185 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 116623319 Nonpathogen - von Willebrand factor, type A Acid_4228 3 None None None 116619868 Common - ATP-dependent DNA helicase, RecQ family Acid_0740 225 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 116621543 Common - protein of unknown function DUF214 Acid_2425 97 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622806 Nonpathogen - hypothetical protein Acid_3706 2 None None None 116623186 Nonpathogen - anti-ECFsigma factor, ChrR Acid_4093 1 COG3806 ChrR, Transcriptional activator Transcription 116624336 Common - Succinylglutamate desuccinylase/aspartoacylase Acid_5254 53 COG3608 COG3608, Predicted deacylase General function prediction only 116622613 Common - hypothetical protein Acid_3511 32 COG2836 COG2836, Uncharacterized conserved protein Function unknown 116623740 Nonpathogen - conserved hypothetical protein, transmembrane prediction Acid_4652 3 None None None 116626389 Common - protein-L-isoaspartate O-methyltransferase Acid_7349 153 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 116623312 Common - Flp pilus assembly protein ATPase CpaE-like protein Acid_4219 54 COG4963 CpaE, Flp pilus assembly protein, ATPase CpaE Intracellular trafficking and secretion 116620335 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Acid_1212 160 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 116620769 Nonpathogen - hypothetical protein Acid_1650 1 None None None 116626578 Nonpathogen - hypothetical protein Acid_7541 1 None None None 116624332 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase Acid_5250 194 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 116622273 Common - recombination protein RecR Acid_3167 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 116623123 Common - metallophosphoesterase Acid_4029 35 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 116625827 Common - Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein Acid_6778 113 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116626221 Common - dihydrodipicolinate synthetase Acid_7181 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 116623280 Common - hypothetical protein Acid_4187 44 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116619712 Common - putative secreted protein, putative xanthan lyase related Acid_0577 24 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 116625355 Common - Methyltransferase type 11 Acid_6300 11 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116624232 Common - putative alpha-1,2-mannosidase Acid_5149 26 COG3537 COG3537, Putative alpha-1,2-mannosidase Carbohydrate transport and metabolism 116625467 Nonpathogen - hypothetical protein Acid_6413 1 None None None 116626710 Nonpathogen - FG-GAP repeat protein Acid_7682 19 None None None 116619391 Common - transcriptional regulator, IclR family Acid_0250 119 COG1414 IclR, Transcriptional regulator Transcription 116622430 Nonpathogen - hypothetical protein Acid_3328 1 None None None 116623251 Common - type II secretion system protein Acid_4158 73 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion 116621662 Common - alpha/beta hydrolase fold Acid_2544 63 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 116622632 Nonpathogen - hypothetical protein Acid_3531 1 None None None 116622682 Nonpathogen - hypothetical protein Acid_3581 1 None None None 116624242 Nonpathogen - hypothetical protein Acid_5159 3 None None None 116626784 Common - protein of unknown function DUF192 Acid_7757 18 COG1430 COG1430, Uncharacterized conserved protein Function unknown 116623289 Nonpathogen - hypothetical protein Acid_4196 2 None None None 116624704 Common - peptidase M22, glycoprotease Acid_5628 160 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 116623528 Common - peptidase M56, BlaR1 Acid_4438 27 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 116624094 Common - beta-lactamase Acid_5009 137 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116621891 Common - hypothetical protein Acid_2774 13 None None None 116624596 Common - FAD dependent oxidoreductase Acid_5520 153 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 116626139 Common - 4-diphosphocytidyl-2C-methyl-D-erythritol kinase Acid_7097 155 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 116626524 Common - protein of unknown function UPF0153 Acid_7487 21 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 116626674 Common - phage integrase family protein Acid_7643 203 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116620361 Nonpathogen - hypothetical protein Acid_1238 1 None None None 116626153 Common - transcriptional regulator, PadR-like family Acid_7112 63 COG1695 COG1695, Predicted transcriptional regulators Transcription 116625208 Common - TonB-dependent receptor, plug Acid_6153 24 COG3164 COG3164, Predicted membrane protein Function unknown 116621494 Common - Methyltransferase type 11 Acid_2376 16 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116624640 Common - protein of unknown function DUF541 Acid_5564 86 COG2968 COG2968, Uncharacterized conserved protein Function unknown 116621342 Common - short-chain dehydrogenase/reductase SDR Acid_2223 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116620832 Nonpathogen - hypothetical protein Acid_1713 1 None None None 116623127 Nonpathogen - hypothetical protein Acid_4033 2 None None None 116621982 Nonpathogen - hypothetical protein Acid_2867 1 None None None 116619997 Nonpathogen - hypothetical protein Acid_0869 1 None None None 116624414 Common - histidine kinase Acid_5336 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116624651 Nonpathogen - hypothetical protein Acid_5575 1 None None None 116625407 Common - beta-lactamase Acid_6352 112 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116619446 Nonpathogen - hypothetical protein Acid_0305 1 None None None 116620599 Common - TonB-dependent receptor, plug Acid_1478 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116621898 Common - conserved hypothetical protein, putative cycloisomerase Acid_2783 57 COG2706 COG2706, 3-carboxymuconate cyclase Carbohydrate transport and metabolism 116623046 Common - oxidoreductase domain protein Acid_3950 155 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116626385 Common - ubiquinone/menaquinone biosynthesis methyltransferase Acid_7345 214 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116625973 Nonpathogen - hypothetical protein Acid_6931 3 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 116620024 Common - nucleic acid-binding protein contains PIN domain-like protein Acid_0896 17 COG1569 COG1569, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 116621729 Common - protein of unknown function DUF214 Acid_2611 10 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116624074 Common - protein of unknown function DUF500 Acid_4988 30 COG2930 COG2930, Uncharacterized conserved protein Function unknown 116621016 Common - Activator of Hsp90 ATPase 1 family protein Acid_1897 12 COG3832 COG3832, Uncharacterized conserved protein Function unknown 116622072 Nonpathogen - hypothetical protein Acid_2959 2 None None None 116621220 Common - TRAP-type uncharacterized transport system periplasmic component-like protein Acid_2101 20 COG2358 Imp, TRAP-type uncharacterized transport system, periplasmic component General function prediction only 116622163 Common - protein of unknown function DUF214 Acid_3055 125 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620475 Common - hypothetical protein Acid_1353 22 None None None 116625794 Nonpathogen - OstA family protein Acid_6744 2 COG1934 COG1934, Uncharacterized protein conserved in bacteria Function unknown 116625315 Common - hypothetical protein Acid_6260 22 None None None 116622025 Common - hypothetical protein Acid_2910 26 COG0657 Aes, Esterase/lipase Lipid metabolism 116626163 Common - glycosyl transferase, group 1 Acid_7123 200 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116624316 Common - cytidine deaminase Acid_5234 113 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 116625221 Nonpathogen - hypothetical protein Acid_6166 1 None None None 116624443 Common - flagellar motor switch protein FliM Acid_5365 105 COG1868 FliM, Flagellar motor switch protein Cell motility and secretion 116625784 Common - aldo/keto reductase Acid_6734 162 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116619525 Common - single-stranded-DNA-specific exonuclease RecJ Acid_0384 194 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 116623490 Common - hypothetical protein Acid_4400 8 COG2234 Iap, Predicted aminopeptidases General function prediction only 116620044 Common tynA tyramine oxidase Acid_0916 22 COG3733 TynA, Cu2+-containing amine oxidase Secondary metabolites biosynthesis, transport, and catabolism 116626290 Common - Glutathione peroxidase Acid_7250 114 COG0386 BtuE, Glutathione peroxidase Posttranslational modification, protein turnover, chaperones 116619838 Common - microcompartments protein Acid_0708 40 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 116624870 Common - RND efflux system, outer membrane lipoprotein, NodT family Acid_5794 131 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116619555 Nonpathogen - hypothetical protein Acid_0416 1 None None None 116620411 Common - Leucyl aminopeptidase Acid_1288 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 116625639 Nonpathogen - hypothetical protein Acid_6588 1 None None None 116620418 Common - TPR repeat-containing protein Acid_1295 39 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116625819 Common - Tetratricopeptide TPR_2 repeat protein Acid_6770 110 COG0457 NrfG, FOG: TPR repeat General function prediction only 116621911 Common - carboxyl-terminal protease Acid_2796 182 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 116624403 Common - oxidoreductase domain protein Acid_5325 159 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116622383 Nonpathogen - hypothetical protein Acid_3277 1 None None None 116625530 Nonpathogen - hypothetical protein Acid_6477 1 None None None 116625176 Nonpathogen - hypothetical protein Acid_6120 1 None None None 116623447 Common - glycosyl transferase, family 2 Acid_4356 79 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116625270 Common - CTP synthetase Acid_6215 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 116625371 Common - protein of unknown function DUF711 Acid_6316 48 COG2848 COG2848, Uncharacterized conserved protein Function unknown 116625663 Common - hypothetical protein Acid_6612 17 None None None 116624066 Common - arsenate reductase related protein Acid_4980 17 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 116622691 Common - TonB-dependent receptor, plug Acid_3590 17 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116626956 Common - adenylylsulfate reductase, thioredoxin dependent Acid_7933 187 COG0529 CysC, Adenylylsulfate kinase and related kinases Inorganic ion transport and metabolism 116620145 Common - peptidase U62, modulator of DNA gyrase Acid_1018 170 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 116624604 Nonpathogen - hypothetical protein Acid_5528 1 None None None 116620960 Common - hypothetical protein Acid_1841 13 None None None 116623169 Common - Quinoprotein glucose dehydrogenase Acid_4075 63 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116626444 Common - DNA polymerase B region Acid_7406 39 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 116623662 Common - transcriptional regulator, ArsR family Acid_4574 35 COG0640 ArsR, Predicted transcriptional regulators Transcription 116623855 Common - hypothetical protein Acid_4767 10 None None None 116621676 Common - cytochrome c, class I Acid_2558 5 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 116619217 Nonpathogen - hypothetical protein Acid_0072 1 None None None 116623917 Common - nicotinate (nicotinamide) nucleotide adenylyltransferase Acid_4829 192 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 116622763 Nonpathogen - hypothetical protein Acid_3662 1 None None None 116621032 Nonpathogen - protein of unknown function DUF820 Acid_1913 3 COG4636 Uma2, Uncharacterized protein conserved in cyanobacteria Function unknown 116626906 Common - protein of unknown function DUF88 Acid_7883 69 COG1432 COG1432, Uncharacterized conserved protein Function unknown 116625118 Nonpathogen - hypothetical protein Acid_6055 1 None None None 116625091 Nonpathogen - hypothetical protein Acid_6026 1 None None None 116622462 Common - glycosyl hydrolase, BNR repeat-containing protein Acid_3360 47 None None None 116625304 Common - beta-lactamase Acid_6249 139 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116619852 Common - acetylglutamate kinase Acid_0724 218 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 116622499 Common - short-chain dehydrogenase/reductase SDR Acid_3397 233 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 116620877 Common - hypothetical protein Acid_1758 6 None None None 116620137 Common - twin-arginine translocation protein, TatA/E family subunit Acid_1010 63 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 116621722 Common - hypothetical protein Acid_2604 20 COG3828 COG3828, Uncharacterized protein conserved in bacteria Function unknown 116623177 Common - Acetamidase/Formamidase Acid_4084 61 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 116620084 Common - Holliday junction DNA helicase RuvA Acid_0956 210 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 116621552 Common - Methyltransferase type 11 Acid_2434 20 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116624617 Common - dimethyladenosine transferase Acid_5541 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 116619822 Common - ATPase associated with various cellular activities, AAA_3 Acid_0692 178 COG0714 COG0714, MoxR-like ATPases General function prediction only 116622735 Nonpathogen - hypothetical protein Acid_3634 1 None None None 116623256 Nonpathogen - hypothetical protein Acid_4163 11 None None None 116622277 Common - multi-sensor hybrid histidine kinase Acid_3171 221 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116624177 Common rpsM 30S ribosomal protein S13 Acid_5093 243 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 116620156 Common hemH ferrochelatase Acid_1029 84 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 116624161 Common ligC ATP-dependent DNA ligase Acid_5077 97 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 116626077 Common - DNA polymerase III, alpha subunit Acid_7035 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 116621441 Common - hypothetical protein Acid_2323 7 None None None 116621328 Common - von Willebrand factor, type A Acid_2209 20 COG4867 COG4867, Uncharacterized protein with a von Willebrand factor type A (vWA) domain General function prediction only 116626636 Common - cell shape determining protein, MreB/Mrl family Acid_7601 208 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 116619327 Common - nitrite reductase (NAD(P)H), large subunit Acid_0184 201 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 116622421 Common - protein of unknown function DUF214 Acid_3318 165 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116626493 Nonpathogen - hypothetical protein Acid_7456 1 None None None 116621039 Common - hypothetical protein Acid_1920 9 None None None 116619990 Common - ABC transporter related protein Acid_0862 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 116625845 Common - phage integrase family protein Acid_6799 218 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116619309 Nonpathogen - hypothetical protein Acid_0166 2 None None None 116623180 Nonpathogen - hypothetical protein Acid_4087 1 None None None 116626696 Common - putative GAF sensor protein Acid_7668 65 COG3605 PtsP, Signal transduction protein containing GAF and PtsI domains Signal transduction mechanisms 116621198 Common - Glycosyl hydrolase family 32, N terminal domain protein Acid_2079 53 COG1621 SacC, Beta-fructosidases (levanase/invertase) Carbohydrate transport and metabolism 116622317 Common - protein of unknown function DUF34 Acid_3211 5 COG0327 COG0327, Uncharacterized conserved protein Function unknown 116620436 Common - beta-lactamase Acid_1314 125 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116626080 Common - PilT protein domain protein Acid_7038 17 COG1569 COG1569, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 116625769 Common - amidohydrolase Acid_6719 39 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116625888 Nonpathogen - hypothetical protein Acid_6842 1 None None None 116621242 Common - glycoside hydrolase 15-related protein Acid_2123 69 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 116622310 Common - hypothetical protein Acid_3204 43 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 116620400 Nonpathogen - preprotein translocase, YajC subunit Acid_1277 1 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 116624671 Nonpathogen - hypothetical protein Acid_5595 5 None None None 116621337 Nonpathogen - hypothetical protein Acid_2218 2 None None None 116619242 Common - transcriptional repressor, CopY family Acid_0097 55 COG3682 COG3682, Predicted transcriptional regulator Transcription 116622986 Common - hypothetical protein Acid_3889 13 None None None 116626942 Nonpathogen - hypothetical protein Acid_7919 2 None None None 116621216 Common - Protein of unknown function DUF1588 Acid_2097 7 None None None 116624710 Common - glycosyl hydrolase, BNR repeat-containing protein Acid_5634 46 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116625777 Common - MgtE intracellular region Acid_6727 168 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 116620645 Nonpathogen - hypothetical protein Acid_1524 9 None None None 116623750 Common - eight transmembrane protein EpsH Acid_4662 27 None None None 116622392 Common - protein of unknown function DUF214 Acid_3286 59 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623091 Common - Pirin domain protein domain protein Acid_3995 141 COG1741 COG1741, Pirin-related protein General function prediction only 116623499 Common - Bile acid:sodium symporter Acid_4409 126 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 116625763 Common - putative transcriptional regulator, CopG family Acid_6713 67 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 116626107 Common - hypothetical protein Acid_7065 5 None None None 116622643 Common - t-RNA-binding domain protein Acid_3542 170 COG0073 ARC1, EMAP domain General function prediction only 116619160 Common - tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA Acid_0015 193 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 116624918 Common - leucyl-tRNA synthetase Acid_5844 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116624080 Common - tRNA pseudouridine synthase A Acid_4994 233 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 116621215 Common - TPR repeat-containing protein Acid_2096 62 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 116621769 Common - putative O-antigen related protein Acid_2651 4 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116622358 Nonpathogen - hypothetical protein Acid_3252 1 None None None 116620130 Nonpathogen - putative L-fucose isomerase Acid_1003 6 COG2407 FucI, L-fucose isomerase and related proteins Carbohydrate transport and metabolism 116625699 Common - hypothetical protein Acid_6648 22 None None None 116621764 Common - conserved hypothetical signal peptide protein Acid_2646 3 None None None 116624771 Common - acetyl-CoA acetyltransferase Acid_5695 178 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 116625048 Nonpathogen - hypothetical protein Acid_5978 2 None None None 116624768 Common - protein of unknown function DUF1080 Acid_5692 7 None None None 116626822 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_7795 34 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116621347 Common - carbon monoxide dehydrogenase subunit G Acid_2228 41 COG3427 COG3427, Uncharacterized conserved protein Function unknown 116621627 Common - penicillin-binding protein, 1A family Acid_2509 203 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 116626541 Common - Radical SAM domain protein Acid_7504 124 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116621231 Common - Pyrrolo-quinoline quinone Acid_2112 76 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116622298 Common - DNA uptake lipoprotein-like protein Acid_3192 114 COG4105 ComL, DNA uptake lipoprotein General function prediction only 116621063 Common - putative transposase protein, Y4bF Acid_1944 20 None None None 116620409 Common - hypothetical protein Acid_1286 26 COG3536 COG3536, Uncharacterized protein conserved in bacteria Function unknown 116624867 Common - hypothetical protein Acid_5791 16 None None None 116626872 Common - AAA ATPase Acid_7847 27 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 116623061 Common - hypothetical protein Acid_3965 83 None None None 116622747 Common - glycoside hydrolase, family 39 Acid_3646 12 COG3664 XynB, Beta-xylosidase Carbohydrate transport and metabolism 116624576 Common - peptidyl-prolyl cis-trans isomerase, cyclophilin type Acid_5500 201 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 116623724 Common - hypothetical protein Acid_4636 6 COG2456 COG2456, Uncharacterized conserved protein Function unknown 116621559 Common - Isoprenylcysteine carboxyl methyltransferase Acid_2441 36 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 116622753 Nonpathogen - hypothetical protein Acid_3652 2 None None None 116620275 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_1152 9 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 116620100 Common - protein of unknown function DUF477 Acid_0973 87 COG1512 COG1512, Beta-propeller domains of methanol dehydrogenase type General function prediction only 116624690 Common - peptidase S9, prolyl oligopeptidase active site domain protein Acid_5614 145 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116619791 Common - Methyltransferase type 11 Acid_0661 22 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116624725 Common - PIN domain family protein Acid_5649 6 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 116620946 Common - hypothetical protein Acid_1827 8 None None None 116621179 Common - short chain dehydrogenase Acid_2060 195 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 116620023 Nonpathogen - CRISPR-associated RAMP protein, Csm5 family Acid_0895 8 COG1332 COG1332, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 116626494 Nonpathogen - flagellar hook capping protein Acid_7457 1 COG1843 FlgD, Flagellar hook capping protein Cell motility and secretion 116621870 Common - PilT protein domain protein Acid_2753 38 COG3744 COG3744, Uncharacterized protein conserved in bacteria Function unknown 116623793 Common - lipoyl synthase Acid_4705 190 COG0320 LipA, Lipoate synthase Coenzyme metabolism 116624655 Common - Hemerythrin HHE cation binding domain protein Acid_5579 12 None None None 116621705 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_2587 9 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116624123 Common - protein of unknown function DUF1549 Acid_5039 5 None None None 116624321 Common phhB pterin-4-alpha-carbinolamine dehydratase Acid_5239 114 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 116619265 Common - TPR repeat-containing protein Acid_0121 111 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116619506 Nonpathogen - hypothetical protein Acid_0365 1 None None None 116625230 Common - hypothetical protein Acid_6175 22 None None None 116625862 Nonpathogen - hypothetical protein Acid_6816 2 None None None 116620066 Nonpathogen - hypothetical protein Acid_0938 1 None None None 116626669 Common - hypothetical protein Acid_7638 3 None None None 116619644 Common - ATPase AAA-2 domain protein Acid_0505 218 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 116621289 Common - TonB-dependent receptor, plug Acid_2170 27 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 116623436 Common - serine phosphatase Acid_4345 121 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 116625103 Nonpathogen - hypothetical protein Acid_6039 1 None None None 116625731 Common - ribonuclease H Acid_6680 175 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 116620277 Common - serine/threonine protein kinase Acid_1154 200 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116625560 Nonpathogen - hypothetical protein Acid_6507 2 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 116620951 Common - protein of unknown function DUF214 Acid_1832 88 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 116622822 Common - GCN5-related N-acetyltransferase Acid_3722 86 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 116623246 Common - outer membrane efflux protein Acid_4153 20 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116621406 Nonpathogen - hypothetical protein Acid_2288 1 None None None 116626142 Common - protein of unknown function DUF214 Acid_7100 56 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 116622291 Common - oxidoreductase domain protein Acid_3185 172 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116624828 Nonpathogen - hypothetical protein Acid_5752 2 None None None 116622365 Common - oligopeptide transporter, OPT family Acid_3259 40 COG1297 COG1297, Predicted membrane protein Function unknown 116623103 Common - 2OG-Fe(II) oxygenase Acid_4007 56 COG3145 AlkB, Alkylated DNA repair protein DNA replication, recombination, and repair 116626622 Common - Rieske (2Fe-2S) domain protein Acid_7585 34 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 116626190 Common - oxidoreductase domain protein Acid_7150 178 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116620813 Nonpathogen - hypothetical protein Acid_1694 2 None None None 116624150 Nonpathogen - hypothetical protein Acid_5066 1 None None None 116625645 Common - phage Gp37Gp68 family protein Acid_6594 42 COG4422 COG4422, Bacteriophage protein gp37 Function unknown 116621784 Common - Alpha-glucuronidase Acid_2666 15 COG3661 AguA, Alpha-glucuronidase Carbohydrate transport and metabolism 116619843 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Acid_0713 1 None None None 116625974 Common - hydrogenase accessory protein HypB Acid_6932 153 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 116625363 Common - von Willebrand factor, type A Acid_6308 18 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 116619874 Common - protein of unknown function DUF490 Acid_0746 74 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 116625658 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Acid_6607 114 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 116623299 Common - integral membrane sensor signal transduction histidine kinase Acid_4206 222 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116625586 Common - Xylose isomerase domain protein TIM barrel Acid_6535 48 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116623080 Common - protein of unknown function DUF323 Acid_3984 89 COG1262 COG1262, Uncharacterized conserved protein Function unknown 116626130 Common - hypothetical protein Acid_7088 3 None None None 116621004 Nonpathogen - hypothetical protein Acid_1885 2 None None None 116620700 Common - acriflavin resistance protein Acid_1580 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116620036 Common rplM 50S ribosomal protein L13 Acid_0908 228 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 116620281 Nonpathogen - hypothetical protein Acid_1158 1 None None None 116625869 Common - transposase IS3/IS911 family protein Acid_6823 32 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 116619218 Common - potassium-transporting ATPase subunit A Acid_0073 96 COG2060 KdpA, K+-transporting ATPase, A chain Inorganic ion transport and metabolism 116622701 Nonpathogen - hypothetical protein Acid_3600 2 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116626236 Common - hypothetical protein Acid_7196 10 None None None 116626011 Common - putative methyltransferase CmuC Acid_6969 12 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 116623361 Common - hypothetical protein Acid_4270 46 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116622853 Common - protein of unknown function DUF323 Acid_3753 81 COG1262 COG1262, Uncharacterized conserved protein Function unknown 116625214 Common - Xylose isomerase domain protein TIM barrel Acid_6159 5 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116626443 Common - 6-phosphogluconate dehydrogenase, NAD-binding Acid_7405 167 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 116625511 Common - Caffeoyl-CoA O-methyltransferase Acid_6458 102 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 116626261 Common - major facilitator superfamily MFS_1 Acid_7221 202 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116624699 Common - Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein Acid_5623 119 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116624036 Common - transcriptional regulator, PadR-like family Acid_4950 66 COG1695 COG1695, Predicted transcriptional regulators Transcription 116622343 Nonpathogen - hypothetical protein Acid_3237 1 None None None 116624060 Common - serine dehydratase alpha chain Acid_4974 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 116621113 Nonpathogen - hypothetical protein Acid_1994 1 None None None 116621290 Nonpathogen - hypothetical protein Acid_2171 1 None None None 116619960 Common - GCN5-related N-acetyltransferase Acid_0832 41 COG2153 ElaA, Predicted acyltransferase General function prediction only 116624709 Nonpathogen - membrane protein Acid_5633 2 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 116622815 Common - membrane protein-like protein Acid_3715 8 COG5305 COG5305, Predicted membrane protein Function unknown 116626426 Nonpathogen - hypothetical protein Acid_7388 5 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116619986 Common - protein of unknown function DUF1549 Acid_0858 6 None None None 116624350 Common - NmrA family protein Acid_5270 39 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116619935 Common - Allergen V5/Tpx-1 family protein Acid_0807 53 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 116626282 Common - 40-residue YVTN family beta-propeller repeat protein Acid_7242 87 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116619325 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_0182 162 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 116620764 Common - two component, sigma54 specific, transcriptional regulator, Fis family Acid_1645 216 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116624860 Common - transposase IS116/IS110/IS902 family protein Acid_5784 87 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116624909 Common - Alcohol dehydrogenase, zinc-binding domain protein Acid_5835 182 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 116626934 Common - protein of unknown function DUF214 Acid_7911 159 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116624943 Common - Xylose isomerase domain protein TIM barrel Acid_5870 10 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116625742 Common - integral membrane sensor signal transduction histidine kinase Acid_6692 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116623934 Common - HpcH/HpaI aldolase Acid_4846 73 COG3836 HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase Carbohydrate transport and metabolism 116620000 Common - TonB-dependent receptor, plug Acid_0872 24 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116625140 Common - hypothetical protein Acid_6078 7 COG4946 COG4946, Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system Function unknown 116626226 Nonpathogen - hypothetical protein Acid_7186 1 None None None 116625018 Common - hypothetical protein Acid_5948 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 116619669 Common - hypothetical protein Acid_0532 5 None None None 116619698 Nonpathogen - hypothetical protein Acid_0563 1 None None None 116625268 Common - hypothetical protein Acid_6213 7 None None None 116624225 Nonpathogen - hypothetical protein Acid_5141 1 COG5617 COG5617, Predicted integral membrane protein Function unknown 116623885 Common - hypothetical protein Acid_4797 11 COG4485 COG4485, Predicted membrane protein Function unknown 116626953 Nonpathogen - conserved hypothetical protein, signal peptide and transmembrane prediction Acid_7930 3 None None None 116621946 Nonpathogen - lipopolysaccharide biosynthesis Acid_2831 1 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 116619728 Nonpathogen - FG-GAP repeat protein Acid_0593 5 None None None 116621695 Common - hypothetical protein Acid_2577 5 None None None 116624351 Common - Cupin 2, conserved barrel domain protein Acid_5271 25 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 116626504 Common - RNA polymerase, sigma 28 subunit, FliA/WhiG family Acid_7467 213 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 116625928 Nonpathogen - hypothetical protein Acid_6885 1 None None None 116622521 Common - phosphoribosyltransferase Acid_3419 170 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 116620612 Common - ceramide glucosyltransferase, putative Acid_1491 32 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116622810 Common - Xylose isomerase domain protein TIM barrel Acid_3710 4 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116620746 Nonpathogen - hypothetical protein Acid_1627 1 None None None 116625965 Common - hydrogenase (NiFe) small subunit HydA Acid_6923 77 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 116621636 Nonpathogen - hypothetical protein Acid_2518 1 None None None 116622841 Common - hypothetical protein Acid_3741 18 None None None 116621180 Common - HipA domain protein Acid_2061 67 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 116620851 Nonpathogen - hypothetical protein Acid_1732 1 None None None 116619816 Common - Tetratricopeptide TPR_2 repeat protein Acid_0686 41 COG2909 MalT, ATP-dependent transcriptional regulator Transcription 116624509 Common - protein of unknown function DUF190 Acid_5433 48 COG1993 COG1993, Uncharacterized conserved protein Function unknown 116619580 Nonpathogen - hypothetical protein Acid_0441 1 None None None 116622087 Common - hypothetical protein Acid_2974 24 None None None 116620494 Common - protein of unknown function DUF224, cysteine-rich region domain protein Acid_1372 119 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 116621949 Common - beta-lactamase domain protein Acid_2834 128 COG1782 COG1782, Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain General function prediction only 116623329 Common - cytochrome c assembly protein Acid_4238 176 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 116623381 Common - hypothetical protein Acid_4290 6 None None None 116625290 Common - Phospholipase C Acid_6235 33 COG3511 PlcC, Phospholipase C Cell envelope biogenesis, outer membrane 116625576 Common - protein of unknown function DUF214 Acid_6524 18 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623811 Common - Endothelin-converting enzyme 1 Acid_4723 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 116624025 Common - calcium/proton antiporter, CaCA family Acid_4937 28 COG0387 ChaA, Ca2+/H+ antiporter Inorganic ion transport and metabolism 116626115 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Acid_7073 175 COG0546 Gph, Predicted phosphatases General function prediction only 116626357 Common - Peptidoglycan glycosyltransferase Acid_7317 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 116623265 Common - hypothetical protein Acid_4172 21 COG3615 TehB, Uncharacterized protein/domain, possibly involved in tellurite resistance Inorganic ion transport and metabolism 116624188 Common - ribosomal protein S8 Acid_5104 242 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 116625553 Common - peptidase M28 Acid_6500 53 COG2234 Iap, Predicted aminopeptidases General function prediction only 116621297 Common - iron (metal) dependent repressor, DtxR family Acid_2178 80 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 116624813 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_5737 36 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116626407 Common - Amidohydrolase 3 Acid_7369 113 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 116621229 Common - hypothetical protein Acid_2110 13 None None None 116624844 Nonpathogen - hypothetical protein Acid_5768 1 None None None 116626522 Common - cobalamin (vitamin B12) biosynthesis CbiX protein Acid_7485 78 COG2138 COG2138, Uncharacterized conserved protein Function unknown 116620688 Common - hypothetical protein Acid_1568 10 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116620795 Nonpathogen - hypothetical protein Acid_1676 1 None None None 116625985 Common - ABC transporter related protein Acid_6943 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116626604 Common - outer membrane efflux protein Acid_7567 126 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116626770 Common - transcriptional regulator, LacI family Acid_7743 130 COG1609 PurR, Transcriptional regulators Transcription 116620778 Common - GatB/Yqey domain protein Acid_1659 11 COG1610 COG1610, Uncharacterized conserved protein Function unknown 116624770 Common - acyl-CoA dehydrogenase domain protein Acid_5694 164 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 116622473 Common - protease Do Acid_3371 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 116626949 Common - transcriptional regulator, MarR family Acid_7926 29 COG1846 MarR, Transcriptional regulators Transcription 116620503 Common - OsmC family protein Acid_1381 38 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 116621390 Nonpathogen - hypothetical protein Acid_2271 1 None None None 116623385 Nonpathogen - hypothetical protein Acid_4294 1 None None None 116620451 Common - Integrase, catalytic region Acid_1329 78 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 116621076 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Acid_1957 49 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 116622306 Common - major facilitator superfamily MFS_1 Acid_3200 108 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116624029 Common - Redoxin domain protein Acid_4941 209 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116620458 Common - putative streptomycin biosynthesis protein StrI Acid_1336 18 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116625161 Common - hypothetical protein Acid_6104 10 COG4632 EpsL, Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase Carbohydrate transport and metabolism 116619276 Nonpathogen - hypothetical protein Acid_0132 2 COG1923 Hfq, Uncharacterized host factor I protein General function prediction only 116623357 Nonpathogen - hypothetical protein Acid_4266 1 None None None 116626774 Common - type II secretion system protein E Acid_7747 207 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 116619460 Common - Rhomboid family protein Acid_0319 148 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 116621772 Common - GCN5-related N-acetyltransferase Acid_2654 44 COG0456 RimI, Acetyltransferases General function prediction only 116622608 Common - hypothetical protein Acid_3506 23 COG2863 COG2863, Cytochrome c553 Energy production and conversion 116620567 Common - histidine kinase Acid_1445 170 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116624957 Common - outer membrane efflux protein Acid_5886 5 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116624746 Nonpathogen - hypothetical protein Acid_5670 1 None None None 116624950 Nonpathogen - hypothetical protein Acid_5879 2 None None None 116626144 Common - conserved hypothetical protein, putative xylan esterase Acid_7102 18 COG3458 COG3458, Acetyl esterase (deacetylase) Secondary metabolites biosynthesis, transport, and catabolism 116625770 Common - amidohydrolase Acid_6720 79 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116620738 Common - peptidase C14, caspase catalytic subunit p20 Acid_1619 105 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116626007 Nonpathogen - hypothetical protein Acid_6965 4 None None None 116626662 Nonpathogen - hypothetical protein Acid_7631 4 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 116620782 Nonpathogen - hypothetical protein Acid_1663 1 None None None 116625546 Common - hypothetical protein Acid_6493 8 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 116621154 Common - hypothetical protein Acid_2035 34 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116626563 Nonpathogen - hypothetical protein Acid_7526 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116620215 Common - 60 kDa inner membrane insertion protein Acid_1090 213 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 116621142 Common - hypothetical protein Acid_2023 24 None None None 116620151 Common - hypothetical protein Acid_1024 6 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 116620619 Common - protein of unknown function DUF107 Acid_1498 71 COG1030 NfeD, Membrane-bound serine protease (ClpP class) Posttranslational modification, protein turnover, chaperones 116623147 Common - dienelactone hydrolase Acid_4053 37 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 116625224 Common - NusG antitermination factor Acid_6169 68 COG0250 NusG, Transcription antiterminator Transcription 116620128 Common - hypothetical protein Acid_1001 4 COG4634 COG4634, Uncharacterized protein conserved in bacteria Function unknown 116621435 Common - Pyridoxal-5'-phosphate-dependent enzyme, beta subunit Acid_2317 193 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 116622886 Nonpathogen - hypothetical protein Acid_3787 1 None None None 116626514 Nonpathogen - hypothetical protein Acid_7477 3 None None None 116619751 Common - hypothetical protein Acid_0617 4 None None None 116622872 Common - hypothetical protein Acid_3773 14 None None None 116621840 Common - peptidase S41 Acid_2722 4 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 116623021 Common - aminopeptidase Acid_3925 27 COG2309 AmpS, Leucyl aminopeptidase (aminopeptidase T) Amino acid transport and metabolism 116620055 Common - penicillin-binding protein, transpeptidase Acid_0927 179 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 116623800 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Acid_4712 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 116624020 Common - FAD dependent oxidoreductase Acid_4932 106 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 116624480 Common - putative neuromedin U Acid_5402 18 None None None 116621717 Common - CMP/dCMP deaminase, zinc-binding Acid_2599 36 COG2131 ComEB, Deoxycytidylate deaminase Nucleotide transport and metabolism 116620902 Common - deoxyxylulose-5-phosphate synthase Acid_1783 226 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 116621371 Nonpathogen - hypothetical protein Acid_2252 2 COG5305 COG5305, Predicted membrane protein Function unknown 116622096 Common - glycoside hydrolase, family 28 Acid_2983 29 COG5434 PGU1, Endopygalactorunase Cell envelope biogenesis, outer membrane 116624165 Common - tyrosinase Acid_5081 3 None None None 116620423 Common - hypothetical protein Acid_1300 21 COG4453 COG4453, Uncharacterized protein conserved in bacteria Function unknown 116625796 Common - chaperonin Cpn10 Acid_6746 214 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 116622601 Nonpathogen - hypothetical protein Acid_3499 1 None None None 116625149 Common - Tetratricopeptide TPR_2 repeat protein Acid_6087 148 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116626307 Common - hypothetical protein Acid_7267 18 COG4485 COG4485, Predicted membrane protein Function unknown 116619618 Nonpathogen - hypothetical protein Acid_0479 1 None None None 116622037 Common - protein of unknown function DUF542, ScdA domain protein Acid_2922 45 COG2846 COG2846, Regulator of cell morphogenesis and NO signaling Cell division and chromosome partitioning 116625858 Nonpathogen - conserved repeat domain Acid_6812 9 None None None 116622589 Common - Redoxin domain protein Acid_3487 158 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 116623940 Common - sulfatase Acid_4852 81 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116623807 Nonpathogen - hypothetical protein Acid_4719 1 None None None 116622363 Nonpathogen - hypothetical protein Acid_3257 1 None None None 116619184 Common - Glu/Leu/Phe/Val dehydrogenase, C terminal Acid_0039 179 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 116623119 Common - hypothetical protein Acid_4025 12 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 116624847 Nonpathogen - hypothetical protein Acid_5771 8 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 116625317 Nonpathogen - phosphate-responsive 1 family protein Acid_6262 2 None None None 116624644 Nonpathogen - hypothetical protein Acid_5568 1 None None None 116620608 Common - Redoxin domain protein Acid_1487 19 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116625112 Common - response regulator receiver protein Acid_6048 188 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 116625250 Nonpathogen - hypothetical protein Acid_6195 1 None None None 116619910 Common - major facilitator superfamily MFS_1 Acid_0782 121 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116623189 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_4096 174 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116625439 Common - putative protein-S-isoprenylcysteine methyltransferase-like protein Acid_6384 10 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 116623926 Common - signal peptidase I Acid_4838 205 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 116625895 Nonpathogen - hypothetical protein Acid_6849 3 None None None 116625779 Common - Aldehyde dehydrogenase (NAD(+)) Acid_6729 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 116621525 Common - PilT protein domain protein Acid_2407 18 COG3744 COG3744, Uncharacterized protein conserved in bacteria Function unknown 116626680 Common - hypothetical protein Acid_7651 13 None None None 116619158 Common - protein of unknown function DUF214 Acid_0013 132 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116624959 Common - chemotaxis protein Acid_5888 84 COG1291 MotA, Flagellar motor component Cell motility and secretion 116621881 Common - type I phosphodiesterase/nucleotide pyrophosphatase Acid_2764 27 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 116619376 Common - virulence protein, SciE type Acid_0234 22 COG4455 ImpE, Protein of avirulence locus involved in temperature-dependent protein secretion General function prediction only 116620849 Common - phosphoesterase Acid_1730 9 COG3511 PlcC, Phospholipase C Cell envelope biogenesis, outer membrane 116621400 Common - amidohydrolase Acid_2282 37 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116623008 Common - peptidylprolyl isomerase, FKBP-type Acid_3912 132 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 116619235 Nonpathogen - hypothetical protein Acid_0090 2 None None None 116622961 Nonpathogen - hypothetical protein Acid_3863 1 None None None 116622412 Common - transcriptional regulator, AraC family Acid_3307 63 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 116624448 Common - MCP methyltransferase, CheR-type Acid_5370 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 116620897 Common - Peptidoglycan-binding domain 1 protein Acid_1778 74 COG2989 COG2989, Uncharacterized protein conserved in bacteria Function unknown 116623229 Common - hypothetical protein Acid_4136 2 None None None 116620258 Common - hypothetical protein Acid_1135 7 None None None 116626795 Common - hypothetical protein Acid_7768 10 None None None 116621620 Common - protein of unknown function DUF1080 Acid_2502 9 None None None 116625915 Common - hypothetical protein Acid_6872 6 None None None 116619215 Common - integral membrane sensor signal transduction histidine kinase Acid_0070 222 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 116620840 Common - DNA polymerase III, delta subunit Acid_1721 60 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 116626863 Common - multi-sensor signal transduction histidine kinase Acid_7838 222 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 116621234 Common - transcriptional regulator, XRE family Acid_2115 105 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 116622714 Common - NUDIX hydrolase Acid_3613 96 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 116622051 Common - Pyruvate dehydrogenase (acetyl-transferring) Acid_2937 187 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 116624851 Common - transport-associated Acid_5775 4 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 116619317 Common - oxidoreductase domain protein Acid_0174 170 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116621963 Common - UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase Acid_2848 156 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 116619676 Common - cytochrome c, class I Acid_0539 6 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 116619607 Common - transcriptional regulator, LacI family Acid_0468 129 COG1609 PurR, Transcriptional regulators Transcription 116624759 Common - NADH (or F420H2) dehydrogenase, subunit C Acid_5683 177 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 116625388 Common - outer membrane efflux protein Acid_6333 109 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116620750 Nonpathogen - hypothetical protein Acid_1631 2 None None None 116619709 Common - NAD-dependent epimerase/dehydratase Acid_0574 231 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116625351 Common - oxidoreductase domain protein Acid_6296 90 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116624245 Common - transposase IS3/IS911 family protein Acid_5162 51 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 116623955 Common - hypothetical protein Acid_4867 28 COG3919 COG3919, Predicted ATP-grasp enzyme General function prediction only 116625529 Common - transposase IS116/IS110/IS902 family protein Acid_6476 87 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116625067 Nonpathogen - hypothetical protein Acid_5997 1 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 116620320 Common - Methyltransferase type 12 Acid_1197 26 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 116621888 Nonpathogen - hypothetical protein Acid_2771 2 None None None 116621091 Common - beta-ketoacyl synthase Acid_1972 216 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 116623425 Common - hypothetical protein Acid_4334 22 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 116619812 Common - ROK family protein Acid_0682 163 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 116619640 Common - TPR repeat-containing protein Acid_0501 7 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 116621049 Common - TonB-dependent receptor Acid_1930 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116619329 Common - major facilitator superfamily MFS_1 Acid_0186 106 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 116625440 Common - gamma-glutamyltransferase Acid_6385 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 116621044 Common - glycoside hydrolase, family 4 Acid_1925 54 COG1486 CelF, Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases Carbohydrate transport and metabolism 116621874 Nonpathogen - hypothetical protein Acid_2757 1 None None None 116623908 Common - transcriptional repressor, CopY family Acid_4820 16 COG3682 COG3682, Predicted transcriptional regulator Transcription 116626188 Common - protein of unknown function DUF433 Acid_7148 25 COG2442 COG2442, Uncharacterized conserved protein Function unknown 116622659 Common - transcriptional regulator, PadR-like family Acid_3558 46 COG1695 COG1695, Predicted transcriptional regulators Transcription 116625044 Common - serine phosphatase Acid_5974 115 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 116626312 Common - beta-lactamase domain protein Acid_7272 203 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 116626179 Common - Abortive infection protein Acid_7139 7 COG4449 COG4449, Predicted protease of the Abi (CAAX) family General function prediction only 116621576 Common - delta-aminolevulinic acid dehydratase Acid_2458 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 116619784 Nonpathogen - hypothetical protein Acid_0654 1 None None None 116623820 Nonpathogen - hypothetical protein Acid_4732 1 None None None 116622213 Common - transcriptional regulator, IclR family Acid_3105 123 COG1414 IclR, Transcriptional regulator Transcription 116623093 Common - putative ribonuclease BN Acid_3997 77 COG1295 Rbn, Predicted membrane protein Function unknown 116623395 Common - response regulator receiver protein Acid_4304 220 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 116620472 Common - hypothetical protein Acid_1350 10 None None None 116623573 Common - Phytanoyl-CoA dioxygenase Acid_4483 12 COG5285 COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin Secondary metabolites biosynthesis, transport, and catabolism 116621483 Common - acriflavin resistance protein Acid_2365 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116624131 Nonpathogen - hypothetical protein Acid_5047 4 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 116622882 Common - TPR repeat-containing protein Acid_3783 15 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116619567 Nonpathogen - hypothetical protein Acid_0428 1 None None None 116621731 Common - protein of unknown function DUF214 Acid_2613 47 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116619976 Common - PHP C-terminal domain protein Acid_0848 81 COG1796 POL4, DNA polymerase IV (family X) DNA replication, recombination, and repair 116624486 Common - glutaminase Acid_5408 72 COG2066 GlsA, Glutaminase Amino acid transport and metabolism 116622149 Common - acetate kinase Acid_3041 162 COG0282 ackA, Acetate kinase Energy production and conversion 116622502 Nonpathogen - hypothetical protein Acid_3400 1 None None None 116623797 Common - MOSC domain containing protein Acid_4709 33 COG3217 COG3217, Uncharacterized Fe-S protein General function prediction only 116622831 Nonpathogen - hypothetical protein Acid_3731 1 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116621691 Common - signal recognition particle protein Acid_2573 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 116625452 Common - phenylalanyl-tRNA synthetase, beta subunit Acid_6397 242 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 116621834 Nonpathogen - hypothetical protein Acid_2716 1 None None None 116619315 Common - hypothetical protein Acid_0172 22 None None None 116619535 Common - two component, sigma54 specific, transcriptional regulator, Fis family Acid_0394 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116623118 Common - protein of unknown function DUF214 Acid_4024 8 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 116626552 Nonpathogen - hypothetical protein Acid_7515 1 None None None 116624275 Common - Methyltransferase type 11 Acid_5193 211 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116624820 Nonpathogen - hypothetical protein Acid_5744 6 COG3199 COG3199, Uncharacterized conserved protein Function unknown 116624293 Common - transcriptional regulator, AsnC family Acid_5211 146 COG1522 Lrp, Transcriptional regulators Transcription 116623291 Nonpathogen - putative transmembrane anti-sigma factor Acid_4198 1 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 116622575 Common - type I phosphodiesterase/nucleotide pyrophosphatase Acid_3473 38 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 116624002 Common - amino acid permease-associated region Acid_4914 183 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116625722 Common - protein of unknown function DUF1385 Acid_6671 31 COG3872 COG3872, Predicted metal-dependent enzyme General function prediction only 116625619 Common - Xylose isomerase domain protein TIM barrel Acid_6568 3 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116622525 Common - hypothetical protein Acid_3423 33 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 116623432 Nonpathogen - hypothetical protein Acid_4341 2 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 116620147 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_1020 164 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116626642 Common - Integrase, catalytic region Acid_7608 48 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 116626491 Common - flagellar basal body rod protein Acid_7454 126 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 116619444 Common - exsB protein Acid_0303 177 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 116621414 Common - amino acid permease-associated region Acid_2296 159 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116621929 Common - protein of unknown function DUF214 Acid_2814 11 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116619515 Common - PilT protein domain protein Acid_0374 14 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 116624752 Common - serine/threonine protein kinase Acid_5676 162 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116626026 Common - peptidase dimerisation domain protein Acid_6984 191 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116620576 Common - peptidase M28 Acid_1455 136 COG2234 Iap, Predicted aminopeptidases General function prediction only 116620102 Common - protein of unknown function DUF1501 Acid_0975 5 COG4102 COG4102, Uncharacterized protein conserved in bacteria Function unknown 116623552 Common - hypothetical protein Acid_4462 19 None None None 116621492 Common - hypothetical protein Acid_2374 3 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 116620242 Nonpathogen - hypothetical protein Acid_1119 1 None None None 116620597 Common - Threonyl/alanyl tRNA synthetase, SAD Acid_1476 242 COG2872 COG2872, Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain General function prediction only 116625191 Common - Tetratricopeptide TPR_2 repeat protein Acid_6136 69 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116620249 Common - ABC transporter related Acid_1126 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116623321 Common - mercuric reductase Acid_4230 244 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 116626611 Common - hypothetical protein Acid_7574 6 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 116619891 Common - transcriptional regulator, PadR-like family Acid_0763 49 COG1695 COG1695, Predicted transcriptional regulators Transcription 116621334 Common - oxidoreductase domain protein Acid_2215 193 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116622242 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Acid_3135 112 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 116624995 Common - Threonine aldolase Acid_5925 107 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 116626323 Common - glycosyl transferase, group 1 Acid_7283 224 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116625664 Common - glucose-methanol-choline oxidoreductase Acid_6613 81 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 116626736 Common - hypothetical protein Acid_7708 4 None None None 116626831 Nonpathogen - hypothetical protein Acid_7804 2 None None None 116620181 Common - ADP-ribosylation/Crystallin J1 Acid_1054 26 COG1397 DraG, ADP-ribosylglycohydrolase Posttranslational modification, protein turnover, chaperones 116622792 Nonpathogen - von Willebrand factor, type A Acid_3692 2 None None None 116619715 Common - Mammalian cell entry related domain protein Acid_0580 53 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 116619764 Common - phage integrase family protein Acid_0630 202 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116626129 Common - beta-lactamase Acid_7087 127 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116620185 Common - integral membrane sensor hybrid histidine kinase Acid_1058 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116624205 Common - translation elongation factor G Acid_5121 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 116622955 Common - Phosphoribosyl-AMP cyclohydrolase Acid_3857 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 116620074 Nonpathogen - tetratricopeptide repeat protein Acid_0946 2 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116626172 Common - hypothetical protein Acid_7132 25 None None None 116625729 Nonpathogen - hypothetical protein Acid_6678 1 COG2948 VirB10, Type IV secretory pathway, VirB10 components Intracellular trafficking and secretion 116626854 Common - galactose-1-phosphate uridylyltransferase Acid_7827 79 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 116625235 Nonpathogen - type I phosphodiesterase/nucleotide pyrophosphatase Acid_6180 22 COG3379 COG3379, Uncharacterized conserved protein Function unknown 116625088 Nonpathogen - hypothetical protein Acid_6022 1 None None None 116623766 Common - hypothetical protein Acid_4678 42 COG2910 COG2910, Putative NADH-flavin reductase General function prediction only 116624637 Common - alpha/beta hydrolase fold Acid_5561 17 COG2267 PldB, Lysophospholipase Lipid metabolism 116623620 Common - hypothetical protein Acid_4530 6 None None None 116625294 Common - Mammalian cell entry related domain protein Acid_6239 16 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 116623686 Common - Diaminopimelate epimerase Acid_4598 194 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 116626284 Common - PBS lyase HEAT domain protein repeat-containing protein Acid_7244 10 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 116620028 Nonpathogen - hypothetical protein Acid_0900 1 None None None 116625581 Nonpathogen - hypothetical protein Acid_6530 1 None None None 116622336 Common - response regulator receiver protein Acid_3230 132 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116621517 Common - DNA topoisomerase I Acid_2399 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 116624808 Common - LmbE family protein Acid_5732 3 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 116622927 Nonpathogen - hypothetical protein Acid_3829 2 None None None 116623463 Common - Phosphopyruvate hydratase Acid_4373 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 116623221 Common - Redoxin domain protein Acid_4128 12 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 116624510 Common - ABC transporter related Acid_5434 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 116619426 Common - glycosyl transferase, family 2 Acid_0285 196 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116624952 Nonpathogen - hypothetical protein Acid_5881 1 None None None 116625410 Nonpathogen - hypothetical protein Acid_6355 1 None None None 116625953 Common - extracellular solute-binding protein, family 3 Acid_6911 18 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 116619320 Common - putative alpha-isopropylmalate/homocitrate synthase family transferase Acid_0177 214 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 116620461 Nonpathogen - hypothetical protein Acid_1339 1 None None None 116619246 Common - Ankyrin Acid_0102 44 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 116623752 Nonpathogen - hypothetical protein Acid_4664 1 None None None 116624858 Common - hypothetical protein Acid_5782 24 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116624105 Nonpathogen - hypothetical protein Acid_5020 1 None None None 116620814 Common - putative DNA helicase Acid_1695 122 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 116621644 Nonpathogen - Tetratricopeptide domain protein Acid_2526 1 None None None 116620465 Common - oxidoreductase domain protein Acid_1343 159 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116626122 Nonpathogen - CopG domain protein DNA-binding domain protein Acid_7080 1 None None None 116623741 Common - glycosyl transferase, group 1 Acid_4653 215 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116624863 Common - amidohydrolase Acid_5787 74 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116625138 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_6075 19 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116621261 Common - hypothetical protein Acid_2142 43 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 116621150 Common - Protein of unknown function DUF1592 Acid_2031 7 None None None 116620586 Nonpathogen - biopolymer transport protein ExbD/TolR Acid_1465 2 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 116625132 Common - Integrase, catalytic region Acid_6069 152 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116622193 Common - hypothetical protein Acid_3085 10 None None None 116620757 Common - hypothetical protein Acid_1638 18 COG3361 COG3361, Uncharacterized conserved protein Function unknown 116624566 Common - hypothetical protein Acid_5490 15 None None None 116619802 Common - glycoside hydrolase, family 28 Acid_0672 28 COG5434 PGU1, Endopygalactorunase Cell envelope biogenesis, outer membrane 116622222 Common - transcriptional regulator, putative ATPase, winged helix family Acid_3115 76 COG3899 COG3899, Predicted ATPase General function prediction only 116622435 Common - hypothetical protein Acid_3333 7 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116619793 Nonpathogen - hypothetical protein Acid_0663 2 None None None 116619908 Common - hypothetical protein Acid_0780 6 None None None 116622947 Common - histidine biosynthesis Acid_3849 215 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 116625881 Nonpathogen - hypothetical protein Acid_6835 1 None None None 116620118 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Acid_0991 167 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 116619151 Common - electron transport protein SCO1/SenC Acid_0006 80 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 116619474 Nonpathogen - flagellar FlbD family protein Acid_0333 9 COG1582 FlgEa, Uncharacterized protein, possibly involved in motility Cell motility and secretion 116621510 Nonpathogen - hypothetical protein Acid_2392 1 None None None 116625054 Common - apurinic endonuclease Apn1 Acid_5984 97 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 116619196 Common - cytidylate kinase Acid_0051 208 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 116620857 Common - Animal haem peroxidase Acid_1738 12 None None None 116621508 Common - hypothetical protein Acid_2390 4 None None None 116620909 Common - ABC-1 domain protein Acid_1790 164 COG0661 AarF, Predicted unusual protein kinase General function prediction only 116625475 Common - Methyltransferase type 11 Acid_6421 32 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116626649 Common - phosphoesterase, PA-phosphatase related Acid_7617 7 None None None 116625264 Common - Rieske (2Fe-2S) domain protein Acid_6209 77 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 116625831 Common - protein of unknown function DUF1680 Acid_6784 31 COG3533 COG3533, Uncharacterized protein conserved in bacteria Function unknown 116620394 Common - OmpA/MotB domain protein Acid_1271 173 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 116626300 Common - Alpha-N-arabinofuranosidase Acid_7260 30 COG3534 AbfA, Alpha-L-arabinofuranosidase Carbohydrate transport and metabolism 116620508 Nonpathogen - hypothetical protein Acid_1386 1 None None None 116619549 Common - Lytic transglycosylase, catalytic Acid_0410 168 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 116625643 Common - GHMP kinase Acid_6592 86 COG0153 GalK, Galactokinase Carbohydrate transport and metabolism 116626746 Common - Smr protein/MutS2 Acid_7718 200 COG1193 COG1193, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 116625144 Common - Endoribonuclease L-PSP Acid_6082 86 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 116622897 Common - protein of unknown function DUF214 Acid_3798 132 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116624234 Common - transcriptional regulator, GntR family Acid_5151 126 COG2188 PhnF, Transcriptional regulators Transcription 116625702 Common - Amidase Acid_6651 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 116626803 Nonpathogen - putative transmembrane anti-sigma factor Acid_7776 1 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 116622378 Nonpathogen - hypothetical protein Acid_3272 2 None None None 116622401 Common - Ig domain protein, group 1 domain protein Acid_3295 117 COG3211 PhoX, Predicted phosphatase General function prediction only 116619988 Common - hypothetical protein Acid_0860 24 None None None 116620564 Common - integral membrane sensor signal transduction histidine kinase Acid_1442 206 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116623041 Common - UbiD family decarboxylase Acid_3945 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 116626113 Nonpathogen - transcriptional regulator, PadR-like family Acid_7071 1 COG1695 COG1695, Predicted transcriptional regulators Transcription 116620033 Common - translation elongation factor Ts Acid_0905 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 116620658 Common - aspartyl-tRNA synthetase Acid_1538 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116623199 Common - glycosyl transferase, family 39 Acid_4106 77 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116624367 Common - Tetratricopeptide TPR_2 repeat protein Acid_5288 22 COG4785 NlpI, Lipoprotein NlpI, contains TPR repeats General function prediction only 116625810 Nonpathogen - hypothetical protein Acid_6761 1 None None None 116624975 Common - Xylose isomerase domain protein TIM barrel Acid_5905 52 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116626925 Common - histidine kinase Acid_7902 133 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 116621279 Nonpathogen - Methyltransferase type 11 Acid_2160 7 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116625606 Common - NADH ubiquinone oxidoreductase, 20 kDa subunit Acid_6555 77 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 116619156 Common - protein of unknown function DUF433 Acid_0011 7 COG2442 COG2442, Uncharacterized conserved protein Function unknown 116625285 Common - glycosyl transferase, group 1 Acid_6230 51 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116622052 Common - hypothetical protein Acid_2938 3 None None None 116625189 Common - cytochrome c, class I Acid_6134 10 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 116620799 Common - hypothetical protein Acid_1680 38 COG4938 COG4938, Uncharacterized conserved protein Function unknown 116623263 Nonpathogen - hypothetical protein Acid_4170 2 None None None 116622828 Nonpathogen - transcriptional regulator, Fis family Acid_3728 1 None None None 116625480 Common - quinolinate synthetase complex, A subunit Acid_6426 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 116623302 Common - (NiFe) hydrogenase maturation protein HypF Acid_4209 112 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 116626766 Nonpathogen - hypothetical protein Acid_7739 1 None None None 116621284 Common - heavy metal sensor signal transduction histidine kinase Acid_2165 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116622559 Common - binding-protein-dependent transport systems inner membrane component Acid_3457 219 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 116625515 Common - integral membrane sensor signal transduction histidine kinase Acid_6462 144 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 116622724 Common - N-acyl-D-amino-acid deacylase Acid_3623 68 COG3653 COG3653, N-acyl-D-aspartate/D-glutamate deacylase Secondary metabolites biosynthesis, transport, and catabolism 116626557 Common - serine/threonine protein kinase Acid_7520 142 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116625403 Common - peptidase M56, BlaR1 Acid_6348 13 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 116624837 Common - protein of unknown function DUF162 Acid_5761 84 COG1556 COG1556, Uncharacterized conserved protein Function unknown 116625245 Common - putative metalloendopeptidase, glycoprotease family Acid_6190 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 116622127 Common - hypothetical protein Acid_3015 13 COG4641 COG4641, Uncharacterized protein conserved in bacteria Function unknown 116619268 Common - hypothetical protein Acid_0124 7 None None None 116623594 Nonpathogen - hypothetical protein Acid_4504 1 None None None 116619881 Common - oxidoreductase domain protein Acid_0753 121 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116624464 Nonpathogen - Methyltransferase type 12 Acid_5386 6 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116620928 Nonpathogen - hypothetical protein Acid_1809 2 None None None 116625335 Common - YD repeat-containing protein Acid_6280 21 None None None 116622173 Common - hypothetical protein Acid_3065 25 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116620533 Common - response regulator receiver protein Acid_1411 133 COG4963 CpaE, Flp pilus assembly protein, ATPase CpaE Intracellular trafficking and secretion 116620631 Nonpathogen - hypothetical protein Acid_1510 2 None None None 116624362 Common - aminotransferase, class I and II Acid_5283 237 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 116621008 Common - ABC transporter related Acid_1889 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 116624552 Common - cyclic nucleotide-binding protein Acid_5476 99 COG4420 COG4420, Predicted membrane protein Function unknown 116619917 Common - hypothetical protein Acid_0789 14 COG3595 COG3595, Uncharacterized conserved protein Function unknown 116624801 Nonpathogen - hypothetical protein Acid_5725 2 None None None 116623146 Common - lipolytic enzyme, G-D-S-L family Acid_4052 16 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116623790 Common - transcriptional regulator, PadR-like family Acid_4702 44 COG1695 COG1695, Predicted transcriptional regulators Transcription 116620549 Nonpathogen - hypothetical protein Acid_1427 1 None None None 116619542 Nonpathogen - Anaerobic dehydrogenases typically selenocysteine-containing-like protein Acid_0401 4 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 116623273 Common - Peptidoglycan glycosyltransferase Acid_4180 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 116622040 Nonpathogen - hypothetical protein Acid_2925 7 None None None 116620913 Common - amidohydrolase Acid_1794 50 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116620447 Nonpathogen - hypothetical protein Acid_1325 1 None None None 116621464 Nonpathogen - hypothetical protein Acid_2346 3 None None None 116624983 Nonpathogen - hypothetical protein Acid_5913 1 None None None 116621412 Common - PAS/PAC sensor hybrid histidine kinase Acid_2294 221 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116622922 Common - Ethanolamine ammonia lyase large subunit Acid_3824 55 COG4303 EutB, Ethanolamine ammonia-lyase, large subunit Amino acid transport and metabolism 116622907 Nonpathogen - hypothetical protein Acid_3808 1 None None None 116623350 Common - histidine kinase Acid_4259 213 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 116625036 Common - hypothetical protein Acid_5966 12 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 116621477 Common - Radical SAM domain protein Acid_2359 110 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116623100 Common - hypothetical protein Acid_4004 9 None None None 116624046 Nonpathogen - hypothetical protein Acid_4960 1 None None None 116625366 Common - aldo/keto reductase Acid_6311 205 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116620292 Nonpathogen - hypothetical protein Acid_1169 1 None None None 116623011 Common nagB glucosamine-6-phosphate deaminase Acid_3915 78 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 116622669 Common - ABC-2 type transporter Acid_3568 107 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116626360 Common - protein of unknown function UPF0040 Acid_7320 37 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 116624584 Common - peptidase M16 domain protein Acid_5508 190 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 116621748 Common - hypothetical protein Acid_2630 44 COG3666 COG3666, Transposase and inactivated derivatives DNA replication, recombination, and repair 116624664 Common - putative transposase protein, Y4bF Acid_5588 20 None None None 116622912 Nonpathogen - hypothetical protein Acid_3813 3 COG2891 MreD, Cell shape-determining protein Cell envelope biogenesis, outer membrane 116624732 Nonpathogen - hypothetical protein Acid_5656 2 None None None 116619658 Common - NHL repeat containing protein Acid_0520 56 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116625932 Common - Tetratricopeptide TPR_2 repeat protein Acid_6889 59 COG4995 COG4995, Uncharacterized protein conserved in bacteria Function unknown 116621954 Nonpathogen - metallophosphoesterase Acid_2839 6 COG1409 Icc, Predicted phosphohydrolases General function prediction only 116624342 Common - anti-sigma-factor antagonist Acid_5260 65 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 116626752 Nonpathogen - hypothetical protein Acid_7725 1 None None None 116624947 Common - aldo/keto reductase Acid_5876 204 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116620937 Common - Endothelin-converting enzyme 1 Acid_1818 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 116620338 Common - aminotransferase, class V Acid_1215 236 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 116622204 Common - TonB-dependent receptor Acid_3096 24 None None None 116626526 Common - Radical SAM domain protein Acid_7489 9 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116620442 Common - cyclic nucleotide-binding protein Acid_1320 15 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 116621805 Nonpathogen - hypothetical protein Acid_2687 1 None None None 116624536 Common - ribosomal protein L1 Acid_5460 246 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 116622177 Common - putative esterase Acid_3069 58 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 116624297 Common - transcriptional regulator, PadR-like family Acid_5215 53 COG1695 COG1695, Predicted transcriptional regulators Transcription 116619358 Common - protein of unknown function DUF82 Acid_0216 46 COG1656 COG1656, Uncharacterized conserved protein Function unknown 116621107 Common - oxidoreductase domain protein Acid_1988 146 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116621309 Nonpathogen - hypothetical protein Acid_2190 1 None None None 116621900 Nonpathogen - hypothetical protein Acid_2785 1 None None None 116623194 Common - protein of unknown function DUF214 Acid_4101 178 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623330 Nonpathogen - hypothetical protein Acid_4239 1 None None None 116625847 Nonpathogen - hypothetical protein Acid_6801 1 None None None 116620079 Common - Tetratricopeptide TPR_4 Acid_0951 5 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116625610 Common - hypothetical protein Acid_6559 7 None None None 116619788 Common - NAD-dependent epimerase/dehydratase Acid_0658 231 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116621427 Common - response regulator receiver protein Acid_2309 187 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 116620221 Common - pectate lyase Acid_1098 16 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116624577 Nonpathogen - hypothetical protein Acid_5501 1 None None None 116621028 Common - protein of unknown function DUF147 Acid_1909 67 COG1624 COG1624, Uncharacterized conserved protein Function unknown 116622283 Common - cytochrome c assembly protein Acid_3177 128 COG4137 COG4137, ABC-type uncharacterized transport system, permease component General function prediction only 116622857 Nonpathogen - hypothetical protein Acid_3758 2 None None None 116620558 Common - Tagatose-bisphosphate aldolase Acid_1436 38 COG3684 LacD, Tagatose-1,6-bisphosphate aldolase Carbohydrate transport and metabolism 116621033 Common - beta-ketoacyl synthase Acid_1914 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116625622 Common - protein of unknown function DUF214 Acid_6571 105 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 116622541 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Acid_3439 116 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116622263 Common - thiol oxidoreductase-like protein Acid_3157 47 COG3488 COG3488, Predicted thiol oxidoreductase Energy production and conversion 116620017 Common - hypothetical protein Acid_0889 17 None None None 116625456 Common - transcriptional regulator, LuxR family Acid_6401 152 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116624938 Nonpathogen - hypothetical protein Acid_5865 1 None None None 116620906 Common - PGAP1 family protein Acid_1787 17 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 116623583 Nonpathogen - hypothetical protein Acid_4493 1 None None None 116626927 Nonpathogen - hypothetical protein Acid_7904 2 None None None 116623034 Common - serine/threonine protein kinase Acid_3938 192 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116622797 Nonpathogen - hypothetical protein Acid_3697 5 None None None 116621594 Common - protease Do Acid_2476 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 116619965 Common - formate dehydrogenase, alpha subunit Acid_0837 172 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 116623482 Common - beta-lactamase domain protein Acid_4392 80 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 116623622 Nonpathogen - hypothetical protein Acid_4532 1 None None None 116622030 Common - Carboxylesterase, type B Acid_2915 54 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 116619146 Common - chromosomal replication initiator protein DnaA Acid_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 116626725 Nonpathogen - hypothetical protein Acid_7697 3 COG4634 COG4634, Uncharacterized protein conserved in bacteria Function unknown 116619943 Nonpathogen - hypothetical protein Acid_0815 1 None None None 116621176 Common - Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein Acid_2057 116 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116621425 Common - protein of unknown function DUF214 Acid_2307 52 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620803 Nonpathogen - hypothetical protein Acid_1684 1 None None None 116620501 Common - methyltransferase FkbM family Acid_1379 28 COG2242 CobL, Precorrin-6B methylase 2 Coenzyme metabolism 116626757 Common - protein of unknown function DUF763 Acid_7730 32 COG1415 COG1415, Uncharacterized conserved protein Function unknown 116626896 Common - two component, sigma54 specific, transcriptional regulator, Fis family Acid_7873 221 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116620967 Common - major facilitator superfamily MFS_1 Acid_1848 143 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116622105 Common - Alpha-N-arabinofuranosidase Acid_2992 29 COG3534 AbfA, Alpha-L-arabinofuranosidase Carbohydrate transport and metabolism 116622120 Common - short-chain dehydrogenase/reductase SDR Acid_3008 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116621568 Common - two component transcriptional regulator, LuxR family Acid_2450 222 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116622997 Common - hypothetical protein Acid_3901 17 None None None 116622707 Common - protein of unknown function DUF214 Acid_3606 9 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623158 Common - multiple antibiotic resistance (MarC)-related protein Acid_4064 155 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 116625198 Common - ApbE family lipoprotein Acid_6143 132 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 116626393 Nonpathogen - hypothetical protein Acid_7353 1 None None None 116625680 Common - Methyltransferase type 11 Acid_6629 140 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116626401 Common - hypothetical protein Acid_7363 19 COG3359 COG3359, Predicted exonuclease DNA replication, recombination, and repair 116619978 Common - DNA-directed DNA polymerase Acid_0850 186 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 116623028 Common - integral membrane sensor hybrid histidine kinase Acid_3932 218 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116624631 Common - glycerol kinase Acid_5555 179 COG0554 GlpK, Glycerol kinase Energy production and conversion 116626904 Common - UDP-N-acetylenolpyruvoylglucosamine reductase Acid_7881 206 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 116620989 Common - pyruvate ferredoxin/flavodoxin oxidoreductase Acid_1870 111 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 116619198 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Acid_0053 172 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 116623998 Common - conserved hypothetical protein, transmembrane prediction Acid_4910 8 None None None 116625190 Common - ASPIC/UnbV domain protein Acid_6135 28 None None None 116621100 Common - glycosyltransferase, MGT family Acid_1981 64 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 116621738 Nonpathogen - hypothetical protein Acid_2620 2 None None None 116622063 Nonpathogen - hypothetical protein Acid_2950 1 None None None 116622626 Nonpathogen - hypothetical protein Acid_3525 9 None None None 116625889 Common - transposase Acid_6843 16 None None None 116619856 Common - ABC transporter related Acid_0728 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 116619487 Common - tRNA (uracil-5-)-methyltransferase Gid Acid_0346 113 COG1206 Gid, NAD(FAD)-utilizing enzyme possibly involved in translation Translation, ribosomal structure and biogenesis 116621253 Nonpathogen - hypothetical protein Acid_2134 1 None None None 116620106 Common - putative xanthan lyase Acid_0979 15 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 116626911 Common - tryptophan synthase subunit beta Acid_7888 224 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 116621710 Common - transposase IS3/IS911 family protein Acid_2592 2 None None None 116621385 Nonpathogen - peptidase domain protein Acid_2266 5 None None None 116624018 Nonpathogen - hypothetical protein Acid_4930 1 None None None 116624310 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Acid_5228 102 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 116624407 Common - NUDIX hydrolase Acid_5329 6 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 116622863 Nonpathogen - hypothetical protein Acid_3764 1 None None None 116622292 Common - phosphate transporter Acid_3186 165 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 116623209 Nonpathogen - hypothetical protein Acid_4116 1 None None None 116623137 Nonpathogen - hypothetical protein Acid_4043 3 None None None 116623360 Nonpathogen - hypothetical protein Acid_4269 2 None None None 116626841 Common - 40-residue YVTN family beta-propeller repeat protein Acid_7814 95 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116619722 Common - 2-acyl-glycerophospho-ethanolamine acyltransferase Acid_0587 229 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116624425 Common - Integrase, catalytic region Acid_5347 78 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 116622029 Common - dienelactone hydrolase Acid_2914 66 COG1073 COG1073, Hydrolases of the alpha/beta superfamily General function prediction only 116622990 Common - hypothetical protein Acid_3893 5 None None None 116624113 Common - Sec-independent protein translocase, TatC subunit Acid_5029 201 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 116624454 Nonpathogen - hypothetical protein Acid_5376 1 None None None 116620697 Common - Xylose isomerase domain protein TIM barrel Acid_1577 15 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116623985 Common - Peptidoglycan-binding LysM Acid_4897 49 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 116622550 Common - band 7 protein Acid_3448 192 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 116625588 Common - hypothetical protein Acid_6537 4 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116624090 Nonpathogen - hypothetical protein Acid_5005 1 None None None 116622049 Nonpathogen - hypothetical protein Acid_2935 1 None None None 116622847 Nonpathogen - hypothetical protein Acid_3747 1 None None None 116622115 Common - sortase family protein Acid_3003 24 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 116621199 Common - N-acyl-D-glucosamine 2-epimerase-like protein Acid_2080 20 COG2942 COG2942, N-acyl-D-glucosamine 2-epimerase Carbohydrate transport and metabolism 116622185 Common - beta-ketoacyl synthase Acid_3077 212 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 116621756 Common - Glucosylceramidase Acid_2638 24 COG5520 COG5520, O-Glycosyl hydrolase Cell envelope biogenesis, outer membrane 116622152 Common - periplasmic binding protein/LacI transcriptional regulator Acid_3044 124 COG1609 PurR, Transcriptional regulators Transcription 116626189 Common - hypothetical protein Acid_7149 5 COG4634 COG4634, Uncharacterized protein conserved in bacteria Function unknown 116622315 Common - hypothetical protein Acid_3209 23 None None None 116622602 Common - phosphate transporter Acid_3500 159 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 116622781 Common - serine/threonine protein kinase Acid_3680 175 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116626345 Common - glutamate racemase Acid_7305 191 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 116625325 Nonpathogen - Ankyrin Acid_6270 6 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 116622142 Common - Inorganic pyrophosphatase Acid_3034 182 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 116621457 Common - WxcM domain protein, C-terminal domain protein Acid_2339 213 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 116621786 Common - Uroporphyrinogen decarboxylase (URO-D) Acid_2668 32 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 116623089 Common - NHL repeat containing protein Acid_3993 38 COG2319 COG2319, FOG: WD40 repeat General function prediction only 116622977 Common - Redoxin domain protein Acid_3880 46 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116623202 Common - hypothetical protein Acid_4109 10 None None None 116620263 Nonpathogen - hypothetical protein Acid_1140 2 COG4980 GvpP, Gas vesicle protein General function prediction only 116625782 Common - NAD-dependent epimerase/dehydratase Acid_6732 71 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116621318 Common - major facilitator superfamily MFS_1 Acid_2199 154 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116620265 Nonpathogen - glycosyl hydrolase, BNR repeat-containing protein Acid_1142 7 None None None 116619623 Common - glycine cleavage system T protein Acid_0484 179 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 116626595 Common - putative transcriptional acitvator, Baf family Acid_7558 111 COG1521 COG1521, Putative transcriptional regulator, homolog of Bvg accessory factor Transcription 116621201 Common - hypothetical protein Acid_2082 2 None None None 116620121 Nonpathogen - hypothetical protein Acid_0994 1 None None None 116624737 Common - acetyl-CoA carboxylase, carboxyl transferase, beta subunit Acid_5661 218 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 116619678 Nonpathogen - hypothetical protein Acid_0541 2 None None None 116620388 Common - Squalene/phytoene synthase Acid_1265 99 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 116625076 Nonpathogen - hypothetical protein Acid_6007 1 None None None 116622239 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_3132 40 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116620026 Common - transcriptional repressor, CopY family Acid_0898 33 COG3682 COG3682, Predicted transcriptional regulator Transcription 116622446 Common - Demethylmenaquinone methyltransferase-like protein Acid_3344 64 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 116622345 Common - amidohydrolase Acid_3239 87 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116622684 Common - TonB-dependent receptor, plug Acid_3583 23 None None None 116619383 Common - putative secreted protein Acid_0241 4 None None None 116619282 Nonpathogen - hypothetical protein Acid_0138 1 None None None 116624334 Common - transcriptional regulator, Fis family Acid_5252 10 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 116626600 Common - protein of unknown function DUF214 Acid_7563 74 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116619378 Common - protein of unknown function DUF1316 Acid_0236 28 COG3518 COG3518, Uncharacterized protein conserved in bacteria Function unknown 116624869 Common - Na+/H+ antiporter NhaC Acid_5793 61 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 116623562 Nonpathogen - hypothetical protein Acid_4472 1 None None None 116621122 Common - Tetratricopeptide TPR_2 repeat protein Acid_2003 123 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116626344 Common - phosphoribosylformylglycinamidine synthase, purS Acid_7304 112 COG1828 PurS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component Nucleotide transport and metabolism 116619627 Common - peptidase T2, asparaginase 2 Acid_0488 82 COG1446 COG1446, Asparaginase Amino acid transport and metabolism 116621830 Common - transposase IS116/IS110/IS902 family protein Acid_2712 88 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116626053 Common - protein of unknown function UPF0118 Acid_7011 168 COG0628 PerM, Predicted permease General function prediction only 116625286 Common - glycosyl transferase, group 1 Acid_6231 211 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116623162 Common - 3-isopropylmalate dehydrogenase Acid_4068 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 116623449 Common - hypothetical protein Acid_4358 4 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116619418 Common - hypothetical protein Acid_0277 2 None None None 116621917 Common - PAS/PAC sensor hybrid histidine kinase Acid_2802 224 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116626251 Common - Integrase, catalytic region Acid_7211 77 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 116622645 Nonpathogen - hypothetical protein Acid_3544 14 None None None 116622415 Common - phage integrase family protein Acid_3311 38 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116621053 Common - hypothetical protein Acid_1934 16 None None None 116621850 Nonpathogen - hypothetical protein Acid_2733 1 None None None 116625105 Common - response regulator receiver protein Acid_6041 221 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116623443 Common - glycosyl transferase, family 2 Acid_4352 189 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116624318 Common - Integrase, catalytic region Acid_5236 78 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 116625898 Nonpathogen - Cupin 2, conserved barrel domain protein Acid_6853 5 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 116620517 Common - Patatin Acid_1395 103 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 116625829 Nonpathogen - hypothetical protein Acid_6782 1 None None None 116626582 Common - flavodoxin/nitric oxide synthase Acid_7545 96 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 116620237 Common - Polyprenyl synthetase Acid_1114 242 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 116621089 Nonpathogen - hypothetical protein Acid_1970 4 COG4099 COG4099, Predicted peptidase General function prediction only 116619451 Nonpathogen - hypothetical protein Acid_0310 5 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 116620135 Common - RNA polymerase, sigma 70 subunit, RpoD family Acid_1008 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 116626350 Common - UDP-N-acetylmuramate--alanine ligase Acid_7310 211 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 116626916 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Acid_7893 168 COG0546 Gph, Predicted phosphatases General function prediction only 116624936 Common - NHL repeat containing protein Acid_5863 13 COG4386 COG4386, Mu-like prophage tail sheath protein gpL General function prediction only 116621549 Nonpathogen - hypothetical protein Acid_2431 2 None None None 116623282 Common - putative endo-1,4-beta-xylanase B Acid_4189 42 COG0657 Aes, Esterase/lipase Lipid metabolism 116622694 Common - serine/threonine protein kinase Acid_3593 206 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116625423 Common - hypothetical protein Acid_6368 9 COG3292 COG3292, Predicted periplasmic ligand-binding sensor domain Signal transduction mechanisms 116625465 Nonpathogen - plasmid stabilization system Acid_6411 6 COG3668 ParE, Plasmid stabilization system protein General function prediction only 116622275 Nonpathogen - hypothetical protein Acid_3169 1 None None None 116623285 Common - transcriptional regulator, AraC family Acid_4192 69 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 116619356 Common - Tetratricopeptide TPR_2 repeat protein Acid_0214 97 COG0457 NrfG, FOG: TPR repeat General function prediction only 116619202 Common - N-acyl-D-amino-acid deacylase Acid_0057 52 COG3653 COG3653, N-acyl-D-aspartate/D-glutamate deacylase Secondary metabolites biosynthesis, transport, and catabolism 116622427 Common - Tetratricopeptide TPR_2 repeat protein Acid_3324 166 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116620721 Common - MscS Mechanosensitive ion channel Acid_1601 167 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 116625971 Common - hydrogenase expression/formation protein HypD Acid_6929 109 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 116623497 Common - hypothetical protein Acid_4407 5 None None None 116623606 Common - ABC-2 type transporter Acid_4516 97 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 116626268 Common - sulphate transporter Acid_7228 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 116619186 Common - integral membrane protein-like protein Acid_0041 16 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 116621344 Common - (2Fe-2S)-binding domain protein Acid_2225 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 116625814 Common - preprotein translocase, SecG subunit Acid_6765 50 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 116619968 Common - conserved hypothetical protein 698 Acid_0840 118 COG2855 COG2855, Predicted membrane protein Function unknown 116623548 Nonpathogen - hypothetical protein Acid_4458 1 None None None 116622843 Common - Endothelin-converting enzyme 1 Acid_3743 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 116624338 Common - metal-dependent hydrolase Acid_5256 12 None None None 116623409 Common - protein of unknown function DUF336 Acid_4318 12 COG3193 GlcG, Uncharacterized protein, possibly involved in utilization of glycolate and propanediol General function prediction only 116623375 Common - protein of unknown function DUF86 Acid_4284 19 COG2361 COG2361, Uncharacterized conserved protein Function unknown 116622859 Common - protein of unknown function DUF1549 Acid_3760 10 None None None 116621659 Common - luciferase family protein Acid_2541 110 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 116623129 Common - hypothetical protein Acid_4035 2 None None None 116625417 Nonpathogen - hypothetical protein Acid_6362 1 None None None 116626246 Common glyQ glycyl-tRNA synthetase subunit alpha Acid_7206 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 116626292 Common - glycosyl hydrolase, BNR repeat-containing protein Acid_7252 43 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116626560 Common - peptidase M16 domain protein Acid_7523 169 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 116624416 Common - Ankyrin Acid_5338 93 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 116626781 Nonpathogen - hypothetical protein Acid_7754 15 None None None 116626258 Common - (2Fe-2S)-binding domain protein Acid_7218 123 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 116619331 Common - Uroporphyrinogen III synthase HEM4 Acid_0188 24 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 116621896 Nonpathogen - hypothetical protein Acid_2781 1 None None None 116624163 Nonpathogen - hypothetical protein Acid_5079 1 None None None 116620999 Nonpathogen - protein of unknown function DUF214 Acid_1880 7 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116621392 Common - Integrase, catalytic region Acid_2273 152 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116625926 Nonpathogen - hypothetical protein Acid_6883 2 None None None 116624544 Nonpathogen - hypothetical protein Acid_5468 1 None None None 116620429 Common - hypothetical protein Acid_1306 27 None None None 116620430 Common - hypothetical protein Acid_1308 18 None None None 116624499 Common - hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha subunit Acid_5423 148 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 116619333 Common - hypothetical protein Acid_0190 7 None None None 116620496 Nonpathogen - hypothetical protein Acid_1374 1 None None None 116625567 Nonpathogen - hypothetical protein Acid_6514 1 None None None 116622065 Common - sortase family protein Acid_2952 38 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 116624747 Common - Ornithine cyclodeaminase Acid_5671 85 COG2423 COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog Amino acid transport and metabolism 116622802 Common - DGPFAETKE family protein Acid_3702 21 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 116624818 Common - methyl-accepting chemotaxis sensory transducer Acid_5742 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 116625255 Common - protein of unknown function DUF433 Acid_6200 26 COG2442 COG2442, Uncharacterized conserved protein Function unknown 116621010 Nonpathogen - hypothetical protein Acid_1891 1 None None None 116623664 Common - putative heme-binding protein Acid_4576 20 COG2863 COG2863, Cytochrome c553 Energy production and conversion 116620080 Nonpathogen - hypothetical protein Acid_0952 1 None None None 116625637 Common - peptidase S9, prolyl oligopeptidase active site domain protein Acid_6586 69 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116624687 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Acid_5611 29 COG4934 COG4934, Predicted protease Posttranslational modification, protein turnover, chaperones 116624357 Nonpathogen - hypothetical protein Acid_5278 1 None None None 116622070 Nonpathogen - putative sigma E regulatory protein, MucB/RseB Acid_2957 2 COG3026 RseB, Negative regulator of sigma E activity Signal transduction mechanisms 116626387 Common - protein of unknown function UPF0150 Acid_7347 40 COG1598 COG1598, Uncharacterized conserved protein Function unknown 116622590 Nonpathogen - hypothetical protein Acid_3488 1 None None None 116619557 Common - GHMP kinase Acid_0418 36 COG2605 COG2605, Predicted kinase related to galactokinase and mevalonate kinase General function prediction only 116620406 Common - Biopolymer transport protein ExbD/TolR Acid_1283 6 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 116619707 Nonpathogen - hypothetical protein Acid_0572 3 None None None 116626161 Nonpathogen - hypothetical protein Acid_7121 5 None None None 116620374 Common - chemotaxis protein Acid_1251 81 COG1291 MotA, Flagellar motor component Cell motility and secretion 116625313 Nonpathogen - 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family-like protein Acid_6258 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116619431 Common - pyridoxine biosynthesis protein Acid_0290 87 COG0214 SNZ1, Pyridoxine biosynthesis enzyme Coenzyme metabolism 116619517 Common - GCN5-related N-acetyltransferase Acid_0376 27 COG0456 RimI, Acetyltransferases General function prediction only 116623701 Nonpathogen - hypothetical protein Acid_4613 2 None None None 116624680 Common - hypothetical protein Acid_5604 11 None None None 116622266 Common obgE GTPase ObgE Acid_3160 249 COG0536 Obg, Predicted GTPase General function prediction only 116620656 Common - peptidase S9, prolyl oligopeptidase active site domain protein Acid_1536 189 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116620976 Common - ferric uptake regulator, Fur family Acid_1857 193 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 116623175 Common - hypothetical protein Acid_4082 43 COG3247 HdeD, Uncharacterized conserved protein Function unknown 116620875 Common - transcriptional regulator, TrmB Acid_1756 26 COG1378 COG1378, Predicted transcriptional regulators Transcription 116623977 Nonpathogen - hypothetical protein Acid_4889 3 COG3861 COG3861, Uncharacterized protein conserved in bacteria Function unknown 116620199 Common - Superoxide dismutase Acid_1072 206 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 116623613 Common - twin-arginine translocation pathway signal Acid_4523 43 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 116620678 Common - Alcohol dehydrogenase GroES domain protein Acid_1558 189 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 116626073 Nonpathogen - hypothetical protein Acid_7031 1 None None None 116625997 Common - methylmalonyl-CoA mutase Acid_6955 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 116626764 Nonpathogen - Cupin 2, conserved barrel domain protein Acid_7737 2 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 116625578 Common - TadE family protein Acid_6527 8 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 116621683 Common - Ribonuclease H Acid_2565 206 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 116619411 Common - diguanylate cyclase Acid_0270 19 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 116623230 Nonpathogen - hypothetical protein Acid_4137 1 None None None 116621681 Nonpathogen - hypothetical protein Acid_2563 1 COG5652 COG5652, Predicted integral membrane protein Function unknown 116624308 Common - acyltransferase 3 Acid_5226 104 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 116626064 Common - metallophosphoesterase Acid_7022 8 COG5555 COG5555, Cytolysin, a secreted calcineurin-like phosphatase Cell motility and secretion 116619903 Common - peptidase S16, lon domain protein Acid_0775 67 COG2802 COG2802, Uncharacterized protein, similar to the N-terminal domain of Lon protease General function prediction only 116619766 Common - phage integrase family protein Acid_0633 106 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116624559 Common - outer membrane efflux protein Acid_5483 106 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116621132 Common - X-Pro dipeptidyl-peptidase C-terminal domain protein Acid_2013 68 COG2936 COG2936, Predicted acyl esterases General function prediction only 116620776 Common - ABC transporter related Acid_1657 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 116619992 Common - ABC-type nitrate/sulfonate/bicarbonate transport system, periplasmic components Acid_0864 49 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 116626923 Common - transcriptional regulator, MarR family Acid_7900 17 COG1846 MarR, Transcriptional regulators Transcription 116623346 Common - short-chain dehydrogenase/reductase SDR Acid_4255 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116624146 Common - Mannonate dehydratase Acid_5062 55 COG1312 UxuA, D-mannonate dehydratase Carbohydrate transport and metabolism 116624513 Common - hypothetical protein Acid_5437 5 None None None 116624087 Common - Pyruvate kinase Acid_5001 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 116619288 Nonpathogen - hypothetical protein Acid_0144 2 None None None 116623440 Common - transcriptional regulator, GntR family Acid_4349 144 COG1609 PurR, Transcriptional regulators Transcription 116622722 Common - TonB-dependent receptor Acid_3621 23 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116624764 Common - proton-translocating NADH-quinone oxidoreductase, chain L Acid_5688 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 116626706 Nonpathogen - hypothetical protein Acid_7678 1 None None None 116621286 Common - major facilitator superfamily MFS_1 Acid_2167 186 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116620624 Common - transposase IS3/IS911 family protein Acid_1503 2 None None None 116625806 Common - Redoxin domain protein Acid_6757 187 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 116623352 Nonpathogen - hypothetical protein Acid_4261 1 None None None 116624348 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_5268 5 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 116623055 Nonpathogen - hypothetical protein Acid_3959 2 None None None 116625840 Nonpathogen - hypothetical protein Acid_6793 1 None None None 116624016 Common - hypothetical protein Acid_4928 3 None None None 116623569 Common - short-chain dehydrogenase/reductase SDR Acid_4479 210 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116626395 Common - RNP-1 like RNA-binding protein Acid_7355 10 COG0724 COG0724, RNA-binding proteins (RRM domain) General function prediction only 116625027 Common - glycoside hydrolase family 2, sugar binding Acid_5957 10 None None None 116620672 Common - hypothetical protein Acid_1552 7 None None None 116622077 Common - protein of unknown function DUF500 Acid_2964 31 COG2930 COG2930, Uncharacterized conserved protein Function unknown 116625669 Nonpathogen - lipopolysaccharide biosynthesis Acid_6618 7 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 116624706 Common - Thiosulfate sulfurtransferase Acid_5630 140 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 116624740 Nonpathogen - hypothetical protein Acid_5664 1 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 116626936 Common - transcriptional regulator, NifA subfamily, Fis Family Acid_7913 177 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 116622895 Nonpathogen - hypothetical protein Acid_3796 5 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116623699 Nonpathogen - hypothetical protein Acid_4611 1 None None None 116624405 Nonpathogen - hypothetical protein Acid_5327 3 COG5373 COG5373, Predicted membrane protein Function unknown 116625333 Common - hypothetical protein Acid_6278 9 None None None 116626772 Common - type II secretion system protein Acid_7745 48 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion 116620974 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_1855 22 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 116624210 Common - haloacid dehalogenase, type II Acid_5126 62 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 116625249 Common - protein of unknown function DUF214 Acid_6194 154 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620835 Common - hypothetical protein Acid_1716 6 None None None 116623763 Nonpathogen - hypothetical protein Acid_4675 1 None None None 116623575 Common - FAD linked oxidase domain protein Acid_4485 198 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 116620171 Common - Quinoprotein glucose dehydrogenase Acid_1044 58 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116626820 Nonpathogen - 2-oxoisovalerate dehydrogenase, E1 component beta subunit Acid_7793 6 None None None 116620718 Common - Glutamine--fructose-6-phosphate transaminase (isomerizing) Acid_1598 235 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 116626679 Nonpathogen - hypothetical protein Acid_7650 1 None None None 116625353 Common - NmrA family protein Acid_6298 110 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116625734 Common - Multidrug resistance efflux pump-like protein Acid_6683 149 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116621226 Common - ASPIC/UnbV domain protein Acid_2107 36 None None None 116624055 Common - short-chain dehydrogenase/reductase SDR Acid_4969 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116623268 Nonpathogen - hypothetical protein Acid_4175 2 None None None 116620820 Nonpathogen - CopG domain protein DNA-binding domain protein Acid_1701 1 None None None 116625877 Common - response regulator receiver protein Acid_6831 209 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116621579 Nonpathogen - hypothetical protein Acid_2461 1 None None None 116626613 Common - NADH dehydrogenase Acid_7576 190 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 116620944 Nonpathogen - hypothetical protein Acid_1825 1 COG3477 COG3477, Predicted periplasmic/secreted protein Function unknown 116625712 Common - amine oxidase Acid_6661 11 COG3349 COG3349, Uncharacterized conserved protein Function unknown 116624877 Common - hypothetical protein Acid_5801 11 None None None 116619898 Nonpathogen - hypothetical protein Acid_0770 1 None None None 116626210 Common - glycogen debranching enzyme GlgX Acid_7170 178 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 116623237 Common - aldo/keto reductase Acid_4144 204 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116622932 Common - hypothetical protein Acid_3834 3 COG2353 COG2353, Uncharacterized conserved protein Function unknown 116620883 Common - transcriptional regulator, PadR-like family Acid_1764 61 COG1695 COG1695, Predicted transcriptional regulators Transcription 116622233 Common - hypothetical protein Acid_3126 23 None None None 116625876 Nonpathogen - hypothetical protein Acid_6830 1 None None None 116626446 Common - sigma54 specific transcriptional regulator, Fis family Acid_7408 173 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116620869 Common - hypothetical protein Acid_1750 16 None None None 116624627 Common - putative integral membrane protein Acid_5551 4 COG4975 GlcU, Putative glucose uptake permease Carbohydrate transport and metabolism 116626870 Nonpathogen - hypothetical protein Acid_7845 1 None None None 116624012 Nonpathogen - hypothetical protein Acid_4924 1 None None None 116624040 Nonpathogen - hypothetical protein Acid_4954 1 None None None 116621650 Common - transcriptional modulator of MazE/toxin, MazF Acid_2532 45 COG2337 MazF, Growth inhibitor Signal transduction mechanisms 116621952 Common - WD40 domain protein beta Propeller Acid_2837 28 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116623875 Common - putative regulatory protein, FmdB family Acid_4787 72 COG2331 COG2331, Uncharacterized protein conserved in bacteria Function unknown 116620018 Nonpathogen - hypothetical protein Acid_0890 1 None None None 116619564 Nonpathogen - hypothetical protein Acid_0425 2 None None None 116620060 Common - TonB-dependent receptor, plug Acid_0932 30 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116626488 Common - flagellar L-ring protein Acid_7451 99 COG2063 FlgH, Flagellar basal body L-ring protein Cell motility and secretion 116620828 Common - hypothetical protein Acid_1709 19 None None None 116623072 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Acid_3976 27 COG4934 COG4934, Predicted protease Posttranslational modification, protein turnover, chaperones 116622963 Common - Asp/Glu racemase Acid_3866 71 COG1794 RacX, Aspartate racemase Cell envelope biogenesis, outer membrane 116624082 Common - polysaccharide deacetylase Acid_4996 17 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 116621310 Nonpathogen - hypothetical protein Acid_2191 1 None None None 116621999 Common - integral membrane sensor hybrid histidine kinase Acid_2884 216 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116620553 Common - NAD-dependent epimerase/dehydratase Acid_1431 48 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116624797 Nonpathogen - putative transmembrane anti-sigma factor Acid_5721 2 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 116622251 Nonpathogen - hypothetical protein Acid_3144 1 None None None 116624592 Common - GCN5-related N-acetyltransferase Acid_5516 14 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 116625713 Common - transcriptional regulator, LacI family Acid_6662 129 COG1609 PurR, Transcriptional regulators Transcription 116624379 Common - putative RNA polymerase, sigma-24 subunit, ECF subfamily Acid_5300 41 COG4941 COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain Transcription 116622774 Common - RecB family exonuclease N Acid_3673 32 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 116626218 Common - virulence factor MVIN family protein Acid_7178 152 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 116624902 Common - Protein of unknown function DUF1592 Acid_5827 7 None None None 116625262 Common - RNA polymerase, sigma 28 subunit, FliA/WhiG family Acid_6207 214 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 116620002 Nonpathogen - hypothetical protein Acid_0874 9 None None None 116623929 Common - PEBP family protein Acid_4841 116 COG1881 COG1881, Phospholipid-binding protein General function prediction only 116621688 Common - 16S rRNA processing protein RimM Acid_2570 76 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 116624121 Nonpathogen - hypothetical protein Acid_5037 1 None None None 116626430 Nonpathogen - hypothetical protein Acid_7392 3 None None None 116623964 Common - hypothetical protein Acid_4876 18 None None None 116624339 Common - carboxyl-terminal protease Acid_5257 181 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 116623896 Common - PfkB domain protein Acid_4808 185 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 116626620 Nonpathogen - hypothetical protein Acid_7583 3 None None None 116619700 Nonpathogen - hypothetical protein Acid_0565 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116625676 Common - Radical SAM domain protein Acid_6625 107 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116619845 Common - sulfatase Acid_0717 91 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116621009 Common - ABC transporter domain protein Acid_1890 247 COG4178 COG4178, ABC-type uncharacterized transport system, permease and ATPase components General function prediction only 116626424 Common - putative transmembrane protein Acid_7386 13 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116622035 Common - (2Fe-2S)-binding domain protein Acid_2920 121 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 116623881 Nonpathogen - hypothetical protein Acid_4793 2 None None None 116620283 Common - Carbonate dehydratase Acid_1160 149 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 116623430 Nonpathogen - hypothetical protein Acid_4339 1 None None None 116623891 Common - transcriptional regulator, GntR family Acid_4803 189 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 116626374 Common - adenosine deaminase Acid_7334 113 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 116624255 Common - PAS/PAC sensor hybrid histidine kinase Acid_5173 213 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116621186 Common - hypothetical protein Acid_2067 22 None None None 116623152 Nonpathogen - hypothetical protein Acid_4058 3 COG1649 COG1649, Uncharacterized protein conserved in bacteria Function unknown 116621116 Common - glycoside hydrolase, family 35 Acid_1997 14 COG1874 LacA, Beta-galactosidase Carbohydrate transport and metabolism 116623789 Common - protein of unknown function DUF214 Acid_4701 95 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620310 Common - hypothetical protein Acid_1187 245 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 116626235 Common - hypothetical protein Acid_7195 8 None None None 116620862 Common - Tetratricopeptide TPR_2 repeat protein Acid_1743 140 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116624247 Common - Alcohol dehydrogenase GroES domain protein Acid_5165 204 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 116625069 Nonpathogen - hypothetical protein Acid_5999 1 None None None 116619406 Nonpathogen - hypothetical protein Acid_0265 6 COG3292 COG3292, Predicted periplasmic ligand-binding sensor domain Signal transduction mechanisms 116619173 Common - protein of unknown function DUF1186 Acid_0028 6 COG3318 COG3318, Predicted metal-binding protein related to the C-terminal domain of SecA General function prediction only 116621408 Common - alpha/beta hydrolase fold Acid_2290 41 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 116620228 Common - glucose-1-phosphate adenylyltransferase Acid_1105 195 COG0448 GlgC, ADP-glucose pyrophosphorylase Carbohydrate transport and metabolism 116621272 Nonpathogen - hypothetical protein Acid_2153 1 COG2979 COG2979, Uncharacterized protein conserved in bacteria Function unknown 116619267 Common - ATP--cobalamin adenosyltransferase Acid_0123 130 COG2096 COG2096, Uncharacterized conserved protein Function unknown 116619872 Common - phosphopantetheine-binding Acid_0744 121 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116619735 Common - aminotransferase, class V Acid_0600 239 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 116623869 Common - dephospho-CoA kinase Acid_4781 202 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 116625656 Common - protein of unknown function DUF191 Acid_6605 38 COG2107 COG2107, Predicted periplasmic solute-binding protein General function prediction only 116625963 Common - short chain dehydrogenase Acid_6921 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116620956 Common - Ornithine cyclodeaminase Acid_1837 76 COG2423 COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog Amino acid transport and metabolism 116623843 Common - protein of unknown function DUF214 Acid_4755 142 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116624353 Common - S-adenosyl-L-homocysteine hydrolase Acid_5273 177 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 116625361 Nonpathogen - hypothetical protein Acid_6306 1 None None None 116626013 Common - protein of unknown function DUF500 Acid_6971 33 COG2930 COG2930, Uncharacterized conserved protein Function unknown 116622877 Common - protein of unknown function DUF214 Acid_3778 51 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623439 Nonpathogen - hypothetical protein Acid_4348 1 None None None 116626598 Common - valyl-tRNA synthetase Acid_7561 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116624822 Common - ATPase associated with various cellular activities, AAA_3 Acid_5746 185 COG0714 COG0714, MoxR-like ATPases General function prediction only 116624009 Nonpathogen - hypothetical protein Acid_4921 9 None None None 116624098 Common - Carbamoyltransferase Acid_5013 52 COG2192 COG2192, Predicted carbamoyl transferase, NodU family Posttranslational modification, protein turnover, chaperones 116626868 Common - ATP dependent DNA ligase Acid_7843 55 None None None 116619492 Common - glycoside hydrolase family 2, sugar binding Acid_0351 71 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 116624170 Common - two component transcriptional regulator, LuxR family Acid_5086 175 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116626698 Common - aminotransferase, class IV Acid_7670 201 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 116619726 Common - putative endoribonuclease L-PSP Acid_0591 193 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 116621071 Common - TonB-dependent receptor, plug Acid_1952 23 None None None 116621236 Common - major facilitator superfamily MFS_1 Acid_2117 159 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116622808 Nonpathogen - hypothetical protein Acid_3708 2 None None None 116623757 Nonpathogen - hypothetical protein Acid_4669 1 None None None 116622611 Nonpathogen - hypothetical protein Acid_3509 1 None None None 116625740 Common - hypothetical protein Acid_6690 18 COG4320 COG4320, Uncharacterized protein conserved in bacteria Function unknown 116620363 Common - hypothetical protein Acid_1240 25 None None None 116621002 Common - glucose sorbosone dehydrogenase Acid_1883 114 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 116625216 Common - transcriptional regulator, Crp/Fnr family Acid_6161 131 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 116625822 Common - Alpha-L-arabinofuranosidase-like protein Acid_6773 29 COG3534 AbfA, Alpha-L-arabinofuranosidase Carbohydrate transport and metabolism 116623516 Common - hypothetical protein Acid_4426 3 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116622380 Common - protein serine/threonine phosphatase Acid_3274 126 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 116622398 Nonpathogen - hypothetical protein Acid_3292 4 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116621656 Nonpathogen - hypothetical protein Acid_2538 1 None None None 116626944 Common - ABC transporter related Acid_7921 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 116620679 Common - threonine synthase Acid_1559 120 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 116624694 Common - LOR/SDH bifunctional enzyme conserved domain protein Acid_5618 33 COG1915 COG1915, Uncharacterized conserved protein Function unknown 116626536 Nonpathogen - hypothetical protein Acid_7499 1 None None None 116620009 Common - cyclase/dehydrase Acid_0881 33 COG4276 COG4276, Uncharacterized conserved protein Function unknown 116622811 Common - hypothetical protein Acid_3711 7 None None None 116621825 Common - ATPase AAA-2 domain protein Acid_2707 214 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 116624128 Common - hypothetical protein Acid_5044 14 None None None 116623887 Common - (2Fe-2S)-binding domain protein Acid_4799 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 116624761 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_5685 189 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 116623149 Common - hypothetical protein Acid_4055 12 None None None 116625056 Common - transcriptional regulator, TetR family Acid_5986 92 COG1309 AcrR, Transcriptional regulator Transcription 116626506 Nonpathogen - hypothetical protein Acid_7469 1 None None None 116620762 Common - hypothetical protein Acid_1643 3 None None None 116624979 Common - Inositol-phosphate phosphatase Acid_5909 211 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 116625886 Common - glycosyl transferase, family 28 Acid_6840 59 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 116621749 Common - hypothetical protein Acid_2631 8 COG0529 CysC, Adenylylsulfate kinase and related kinases Inorganic ion transport and metabolism 116624237 Nonpathogen - hypothetical protein Acid_5154 1 None None None 116626655 Common - serine/threonine protein kinase Acid_7624 153 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116621618 Common - KpsF/GutQ family protein Acid_2500 165 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 116626097 Common - ATP-dependent protease La Acid_7055 215 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 116623835 Common - hypothetical protein Acid_4747 11 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116621364 Common - 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family Acid_2245 101 COG1778 COG1778, Low specificity phosphatase (HAD superfamily) General function prediction only 116622381 Common - serine/threonine protein kinase Acid_3275 145 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116621218 Nonpathogen - hypothetical protein Acid_2099 1 None None None 116624945 Nonpathogen - hypothetical protein Acid_5874 1 None None None 116625983 Common - Methyltransferase type 11 Acid_6941 12 COG4627 COG4627, Uncharacterized protein conserved in bacteria Function unknown 116621382 Common - anti-sigma-factor antagonist Acid_2263 20 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 116621792 Nonpathogen - hypothetical protein Acid_2674 1 None None None 116626339 Common - aldo/keto reductase Acid_7299 156 COG1453 COG1453, Predicted oxidoreductases of the aldo/keto reductase family General function prediction only 116623906 Common - oxidoreductase domain protein Acid_4818 124 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116623410 Common - hypothetical protein Acid_4319 7 None None None 116619818 Common - plasmid maintenance system killer Acid_0688 56 COG3549 HigB, Plasmid maintenance system killer protein General function prediction only 116623387 Common - response regulator receiver protein Acid_4296 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116623938 Nonpathogen - hypothetical protein Acid_4850 6 None None None 116625178 Nonpathogen - hypothetical protein Acid_6122 1 None None None 116626602 Common - Methyltransferase type 12 Acid_7565 42 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116623743 Common - glycosyl transferase, group 1 Acid_4655 113 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116626890 Common - transcriptional regulator, Crp/Fnr family Acid_7867 161 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 116620354 Common - ribulokinase Acid_1231 132 COG1069 AraB, Ribulose kinase Energy production and conversion 116624430 Common - lipoprotein signal peptidase Acid_5352 193 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116619660 Nonpathogen - hypothetical protein Acid_0522 1 None None None 116625612 Common - hydrogenase maturation protease Acid_6561 49 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 116624815 Nonpathogen - hypothetical protein Acid_5739 2 None None None 116620520 Common - coagulation factor 5/8 type domain protein Acid_1398 28 COG3669 COG3669, Alpha-L-fucosidase Carbohydrate transport and metabolism 116624881 Common - hypothetical protein Acid_5805 43 COG3247 HdeD, Uncharacterized conserved protein Function unknown 116624501 Common - acetyl-CoA hydrolase/transferase Acid_5425 98 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 116625949 Common - cytochrome c oxidase, subunit III Acid_6907 77 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 116619804 Common - glycoside hydrolase, family 28 Acid_0674 24 COG5434 PGU1, Endopygalactorunase Cell envelope biogenesis, outer membrane 116621367 Common - DegT/DnrJ/EryC1/StrS aminotransferase Acid_2248 194 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 116622817 Common - peptidase M48, Ste24p Acid_3717 106 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116625383 Nonpathogen - hypothetical protein Acid_6328 2 None None None 116626589 Common - peptidase M15D, vanX D-ala-D-ala dipeptidase Acid_7552 60 COG2173 DdpX, D-alanyl-D-alanine dipeptidase Cell envelope biogenesis, outer membrane 116621080 Nonpathogen - hypothetical protein Acid_1961 1 None None None 116624186 Common - ribosomal protein L18 Acid_5102 217 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 116626416 Nonpathogen - hypothetical protein Acid_7378 1 None None None 116623383 Common - hypothetical protein Acid_4292 5 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 116624286 Common - protoporphyrinogen oxidase Acid_5204 57 COG1232 HemY, Protoporphyrinogen oxidase Coenzyme metabolism 116620797 Common - putative bacteriophage-related protein Acid_1678 13 None None None 116625237 Nonpathogen - hypothetical protein Acid_6182 4 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116622247 Nonpathogen - putative transmembrane anti-sigma factor Acid_3140 1 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 116622599 Common - Amidase Acid_3497 220 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 116619294 Common - phage Tail Collar domain protein Acid_0150 35 COG4675 MdpB, Microcystin-dependent protein Function unknown 116620099 Nonpathogen - hypothetical protein Acid_0972 4 None None None 116624262 Common - NusA antitermination factor Acid_5180 221 COG0195 NusA, Transcription elongation factor Transcription 116621268 Common - peptidase M16 domain protein Acid_2149 160 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 116621698 Common - sulfatase Acid_2580 86 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116620740 Common - hypothetical protein Acid_1621 7 None None None 116622013 Common - DNA methylase N-4/N-6 domain protein Acid_2898 126 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 116621678 Common - peptidase M1, membrane alanine aminopeptidase Acid_2560 170 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 116621534 Common - PhoPQ-activated pathogenicity-related protein Acid_2416 14 COG4287 PqaA, PhoPQ-activated pathogenicity-related protein General function prediction only 116623655 Common - TonB-dependent receptor, plug Acid_4567 25 None None None 116621196 Common - aldehyde dehydrogenase Acid_2077 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 116620643 Common - oxidoreductase, molybdopterin binding Acid_1522 98 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 116622676 Common - transposase IS3/IS911 family protein Acid_3575 51 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 116621777 Nonpathogen - hypothetical protein Acid_2659 1 None None None 116626714 Nonpathogen - hypothetical protein Acid_7686 1 None None None 116622465 Nonpathogen - hypothetical protein Acid_3363 1 None None None 116621017 Nonpathogen - hypothetical protein Acid_1898 7 None None None 116620158 Common - transcriptional repressor, CopY family Acid_1031 55 COG3682 COG3682, Predicted transcriptional regulator Transcription 116625694 Nonpathogen - hypothetical protein Acid_6643 2 COG4105 ComL, DNA uptake lipoprotein General function prediction only 116626609 Common - serine/threonine protein kinase Acid_7572 182 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116626963 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_7940 160 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116626638 Common - plasmid encoded RepA protein Acid_7603 10 None None None 116625201 Nonpathogen - hypothetical protein Acid_6146 2 None None None 116626899 Nonpathogen - hypothetical protein Acid_7876 2 None None None 116621339 Common - glycoside hydrolase, family 3 domain protein Acid_2220 178 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 116621558 Common - Alcohol dehydrogenase, zinc-binding domain protein Acid_2440 217 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 116625204 Common - Endoribonuclease L-PSP Acid_6149 149 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 116625728 Nonpathogen - protein of unknown function DUF433 Acid_6677 1 COG2442 COG2442, Uncharacterized conserved protein Function unknown 116623674 Common - N-acetylmuramoyl-L-alanine amidase Acid_4586 181 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 116619854 Common - hypothetical protein Acid_0726 39 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 116621321 Nonpathogen - hypothetical protein Acid_2202 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116622865 Common - Cupin 2, conserved barrel domain protein Acid_3766 2 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 116621499 Common - Methyltransferase type 12 Acid_2381 58 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116622003 Nonpathogen - hypothetical protein Acid_2888 1 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 116623167 Common - alpha-2-macroglobulin domain protein Acid_4073 45 COG2373 COG2373, Large extracellular alpha-helical protein General function prediction only 116621704 Nonpathogen - hypothetical protein Acid_2586 1 None None None 116622168 Nonpathogen - hypothetical protein Acid_3060 1 None None None 116624872 Common - arginine/ornithine antiporter Acid_5796 149 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116620034 Common - ribosomal protein S2 Acid_0906 244 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 116626450 Common - methylmalonyl-CoA mutase, large subunit Acid_7412 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 116626888 Common - histidine kinase Acid_7865 143 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 116622371 Common - transcriptional regulator, TetR family Acid_3265 82 COG1309 AcrR, Transcriptional regulator Transcription 116626464 Common - hypothetical protein Acid_7427 5 None None None 116620610 Nonpathogen - peptidase M56, BlaR1 Acid_1489 1 None None None 116621664 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_2546 143 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116622080 Nonpathogen - hypothetical protein Acid_2967 1 None None None 116620046 Common - peptidase S41 Acid_0918 9 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 116621992 Common - protein of unknown function UPF0118 Acid_2877 102 COG0628 PerM, Predicted permease General function prediction only 116622552 Common - aminotransferase, class V Acid_3450 231 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 116624981 Common - molybdopterin biosynthesis MoaE Acid_5911 155 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 116621728 Common - transcriptional regulator, PadR-like family Acid_2610 16 COG1695 COG1695, Predicted transcriptional regulators Transcription 116626382 Common - transcriptional regulator, AraC family Acid_7342 26 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 116623087 Common - protein of unknown function DUF214 Acid_3991 123 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622450 Common - peptidase M20 Acid_3348 52 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116622390 Nonpathogen - hypothetical protein Acid_3284 1 None None None 116619240 Nonpathogen - hypothetical protein Acid_0095 1 None None None 116621803 Common - TonB-dependent receptor Acid_2685 23 None None None 116623784 Common - anti-sigma-factor antagonist Acid_4696 19 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 116622490 Common - Tetratricopeptide TPR_2 repeat protein Acid_3388 40 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116622279 Common - Methyltransferase type 11 Acid_3173 131 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116619614 Common tdh L-threonine 3-dehydrogenase Acid_0475 206 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 116625142 Common - 40-residue YVTN family beta-propeller repeat protein Acid_6080 63 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116622984 Common - short-chain dehydrogenase/reductase SDR Acid_3887 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116623070 Common - ExsB family protein Acid_3974 64 COG1606 COG1606, ATP-utilizing enzymes of the PP-loop superfamily General function prediction only 116620748 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_1629 16 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116624784 Common - protein of unknown function DUF1501 Acid_5708 5 COG4102 COG4102, Uncharacterized protein conserved in bacteria Function unknown 116625119 Common - integral membrane sensor hybrid histidine kinase Acid_6056 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116626958 Common - acetyl-CoA carboxylase, carboxyl transferase, alpha subunit Acid_7935 184 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 116621913 Common - hypothetical protein Acid_2798 12 None None None 116621586 Common - potassium transporter (trk family) Acid_2468 75 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 116619578 Common - putative DNA topoisomerase I Acid_0439 45 COG3569 COG3569, Topoisomerase IB DNA replication, recombination, and repair 116619798 Common - transcriptional regulator, GntR family Acid_0668 119 COG1802 GntR, Transcriptional regulators Transcription 116619824 Common - thioredoxin Acid_0694 225 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 116620176 Common - hypothetical protein Acid_1049 14 None None None 116619933 Nonpathogen - LmbE family protein Acid_0805 1 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 116622737 Common - two component transcriptional regulator, winged helix family Acid_3636 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116626351 Common - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Acid_7311 208 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 116624692 Common - protein of unknown function DUF433 Acid_5616 13 COG2442 COG2442, Uncharacterized conserved protein Function unknown 116620736 Common - hypothetical protein Acid_1617 2 None None None 116621149 Common - aminotransferase, class I and II Acid_2030 231 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 116624222 Common - Uncharacterised conserved protein UCP033563 Acid_5138 49 COG4198 COG4198, Uncharacterized conserved protein Function unknown 116624927 Common - hypothetical protein Acid_5854 17 COG1724 COG1724, Predicted periplasmic or secreted lipoprotein Cell motility and secretion 116622940 Common - hypothetical protein Acid_3842 17 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 116623063 Nonpathogen - hypothetical protein Acid_3967 5 None None None 116623948 Common - DegT/DnrJ/EryC1/StrS aminotransferase Acid_4860 194 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 116621349 Common - Integrase, catalytic region Acid_2230 78 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 116623182 Common - imidazolonepropionase Acid_4089 100 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116622284 Common - Shikimate/quinate 5-dehydrogenase Acid_3178 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 116621799 Common - Endo-1,4-beta-xylanase Acid_2681 33 COG3693 XynA, Beta-1,4-xylanase Carbohydrate transport and metabolism 116625046 Common - peptidase C14, caspase catalytic subunit p20 Acid_5976 102 COG4249 COG4249, Uncharacterized protein containing caspase domain General function prediction only 116622618 Nonpathogen - hypothetical protein Acid_3517 1 None None None 116621927 Common - nitrogen-fixing NifU domain protein Acid_2812 146 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 116623924 Nonpathogen - hypothetical protein Acid_4836 1 None None None 116626970 Common - protein of unknown function DUF214 Acid_7947 48 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 116625095 Common - Methyltransferase type 11 Acid_6031 117 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116621625 Nonpathogen - aminoglycoside phosphotransferase Acid_2507 4 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 116621240 Common - serine/threonine protein kinase Acid_2121 156 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116623718 Common - colanic acid biosynthesis glycosyl transferase, putative Acid_4630 53 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116623125 Common - transposase IS116/IS110/IS902 family protein Acid_4031 87 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116622486 Common - OmpA/MotB domain protein Acid_3384 118 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 116623860 Common - transcriptional regulator, PadR-like family Acid_4772 38 COG1695 COG1695, Predicted transcriptional regulators Transcription 116620086 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Acid_0958 203 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 116623170 Common - Xylose isomerase domain protein TIM barrel Acid_4076 42 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116623853 Nonpathogen - hypothetical protein Acid_4765 7 None None None 116626883 Common - protein of unknown function DUF185 Acid_7859 89 COG1565 COG1565, Uncharacterized conserved protein Function unknown 116624916 Common - death-on-curing family protein Acid_5842 62 COG3654 Doc, Prophage maintenance system killer protein General function prediction only 116623418 Common - Lysine exporter protein (LYSE/YGGA) Acid_4327 17 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 116623722 Nonpathogen - hypothetical protein Acid_4634 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116626191 Common - glycosyl transferase, group 1 Acid_7151 83 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116624773 Common - transcriptional regulator, TetR family Acid_5697 103 COG1309 AcrR, Transcriptional regulator Transcription 116620230 Common - Na+/solute symporter Acid_1107 128 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 116624179 Common - translation initiation factor IF-1 Acid_5095 198 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 116624290 Common - glutamate formiminotransferase Acid_5208 24 COG3643 COG3643, Glutamate formiminotransferase Amino acid transport and metabolism 116623858 Nonpathogen - hypothetical protein Acid_4770 1 None None None 116619587 Nonpathogen - hypothetical protein Acid_0448 2 COG2318 DinB, Uncharacterized protein conserved in bacteria Function unknown 116624071 Common - hypothetical protein Acid_4985 5 None None None 116622749 Common - (2Fe-2S)-binding domain protein Acid_3648 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 116619685 Common - rfaE bifunctional protein Acid_0550 107 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 116619465 Common - Ethanolamine utilization protein EutN/carboxysome structural protein Ccml Acid_0324 14 COG4576 CcmL, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 116620091 Common - hypothetical protein Acid_0963 5 None None None 116622356 Common - Cystathionine gamma-synthase Acid_3250 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 116619364 Common - serine/threonine protein kinase Acid_0222 154 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116621123 Common - penicillin-binding protein, 1A family Acid_2004 201 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 116626487 Common flgI flagellar basal body P-ring protein Acid_7450 105 COG1706 FlgI, Flagellar basal-body P-ring protein Cell motility and secretion 116620601 Common - Myo-inositol catabolism IolB domain protein Acid_1480 53 COG3718 IolB, Uncharacterized enzyme involved in inositol metabolism Carbohydrate transport and metabolism 116624713 Common - transcriptional regulator, PadR-like family Acid_5637 18 COG1695 COG1695, Predicted transcriptional regulators Transcription 116625562 Nonpathogen - hypothetical protein Acid_6509 1 None None None 116621976 Common - Tetratricopeptide TPR_2 repeat protein Acid_2861 50 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116622464 Nonpathogen - hypothetical protein Acid_3362 1 None None None 116624758 Nonpathogen - hypothetical protein Acid_5682 1 None None None 116626100 Common - methylthioadenosine phosphorylase Acid_7058 144 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 116620884 Common - protein of unknown function DUF214 Acid_1765 98 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116619595 Common - histidine kinase Acid_0456 225 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116620206 Common - phosphoenolpyruvate carboxykinase Acid_1079 97 COG1866 PckA, Phosphoenolpyruvate carboxykinase (ATP) Energy production and conversion 116624193 Common - ribosomal protein S17 Acid_5109 225 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 116625093 Nonpathogen - PEGA domain protein Acid_6029 4 None None None 116619565 Common - sigma54 specific transcriptional regulator, Fis family Acid_0426 176 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 116624597 Common - Methyltransferase type 11 Acid_5521 150 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116625008 Nonpathogen - hypothetical protein Acid_5938 1 None None None 116625697 Common - Radical SAM domain protein Acid_6646 96 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 116626201 Common - amidohydrolase 2 Acid_7161 49 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 116622757 Common - protein of unknown function DUF1080 Acid_3656 15 COG3828 COG3828, Uncharacterized protein conserved in bacteria Function unknown 116623648 Common - outer membrane efflux protein Acid_4560 50 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116625124 Common - IstB domain protein ATP-binding protein Acid_6061 111 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 116623736 Common - glycosyl transferase, family 2 Acid_4648 128 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116625864 Nonpathogen - hypothetical protein Acid_6818 1 None None None 116624400 Common - hypothetical protein Acid_5322 14 COG3802 GguC, Uncharacterized protein conserved in bacteria Function unknown 116626782 Nonpathogen - Flp/Fap pilin component Acid_7755 1 COG3847 Flp, Flp pilus assembly protein, pilin Flp Intracellular trafficking and secretion 116623393 Common - hypothetical protein Acid_4302 15 None None None 116621986 Common - sulfatase Acid_2871 80 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116625206 Nonpathogen - hypothetical protein Acid_6151 3 None None None 116622664 Common - ATP dependent DNA ligase Acid_3563 108 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 116619576 Common - response regulator receiver modulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase Acid_0437 245 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 116624548 Common - Tetratricopeptide TPR_2 repeat protein Acid_5472 118 COG0457 NrfG, FOG: TPR repeat General function prediction only 116619806 Common - glycosyl hydrolase, BNR repeat-containing protein Acid_0676 14 None None None 116621246 Common - glycosyl hydrolase, BNR repeat-containing protein Acid_2127 28 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116626570 Common - Xylose isomerase domain protein TIM barrel Acid_7533 69 COG3622 Hfi, Hydroxypyruvate isomerase Carbohydrate transport and metabolism 116626157 Common - CrcB protein Acid_7117 185 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 116622293 Common - protein of unknown function DUF47 Acid_3187 73 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 161541288 Common rpsL 30S ribosomal protein S12 Acid_5123 245 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 116620005 Common - Radical SAM domain protein Acid_0877 75 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116623398 Common - Protein of unknown function DUF1592 Acid_4307 7 None None None 116622731 Common - protein of unknown function DUF1555 Acid_3630 11 None None None 116625960 Common - excinuclease ABC, A subunit Acid_6918 235 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 116620623 Common - apolipoprotein N-acyltransferase Acid_1502 168 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 116624057 Nonpathogen - hypothetical protein Acid_4971 5 COG2928 COG2928, Uncharacterized conserved protein Function unknown 116626497 Nonpathogen - hypothetical protein Acid_7460 1 COG3190 FliO, Flagellar biogenesis protein Cell motility and secretion 116620279 Common - Alpha,alpha-trehalose-phosphate synthase (UDP-forming) Acid_1156 96 COG0380 OtsA, Trehalose-6-phosphate synthase Carbohydrate transport and metabolism 116622879 Common - protein of unknown function DUF152 Acid_3780 182 COG1496 COG1496, Uncharacterized conserved protein Function unknown 116624190 Common rplE 50S ribosomal protein L5 Acid_5106 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 116625924 Common - Ig family protein Acid_6881 151 None None None 116622402 Common - transcriptional regulator, PadR-like family Acid_3296 42 COG1695 COG1695, Predicted transcriptional regulators Transcription 116626466 Nonpathogen - hypothetical protein Acid_7429 1 None None None 116621241 Common - PfkB domain protein Acid_2122 79 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 116619442 Common - histone deacetylase superfamily Acid_0301 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 116620201 Common - glutamyl-tRNA(Gln) amidotransferase, C subunit Acid_1074 142 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 116624776 Common - AMP-dependent synthetase and ligase Acid_5700 212 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 116624295 Nonpathogen - hypothetical protein Acid_5213 1 None None None 116625726 Common - hypothetical protein Acid_6675 4 None None None 116626625 Nonpathogen - hypothetical protein Acid_7588 1 None None None 116624281 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_5199 18 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 116620873 Common - two component, sigma54 specific, transcriptional regulator, Fis family Acid_1754 217 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116622240 Common - TPR repeat-containing protein Acid_3133 46 COG4995 COG4995, Uncharacterized protein conserved in bacteria Function unknown 116624997 Common - TPR repeat-containing protein Acid_5927 76 COG5616 COG5616, Predicted integral membrane protein Function unknown 116624831 Nonpathogen - hypothetical protein Acid_5755 1 None None None 116620015 Nonpathogen - hypothetical protein Acid_0887 1 None None None 116626723 Common - PilT protein domain protein Acid_7695 29 COG5573 COG5573, Predicted nucleic-acid-binding protein, contains PIN domain General function prediction only 116621394 Common - Ferritin, Dps family protein Acid_2276 40 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 116619310 Common - CoA-binding domain protein Acid_0167 207 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 116625883 Nonpathogen - hypothetical protein Acid_6837 1 COG2060 KdpA, K+-transporting ATPase, A chain Inorganic ion transport and metabolism 116626894 Common - signal peptide peptidase SppA, 67K type Acid_7871 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 116619931 Nonpathogen - hypothetical protein Acid_0803 1 None None None 116620791 Common - hypothetical protein Acid_1672 5 None None None 116620414 Common - aconitate hydratase 1 Acid_1291 222 COG1048 AcnA, Aconitase A Energy production and conversion 116620647 Nonpathogen - hypothetical protein Acid_1527 1 None None None 116626317 Common - UDP-glucose 4-epimerase Acid_7277 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 116626946 Common - amidohydrolase Acid_7923 93 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116624907 Common - putative PAS/PAC sensor protein Acid_5833 144 COG2202 AtoS, FOG: PAS/PAC domain Signal transduction mechanisms 116623667 Nonpathogen - hypothetical protein Acid_4579 2 None None None 116621935 Common - Alpha-galactosidase Acid_2820 15 COG3345 GalA, Alpha-galactosidase Carbohydrate transport and metabolism 116622281 Common - hypothetical protein Acid_3175 39 None None None 116623715 Common - diguanylate cyclase Acid_4627 176 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 116626238 Common - PAS/PAC sensor hybrid histidine kinase Acid_7198 221 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116625312 Common - hypothetical protein Acid_6257 5 None None None 116620887 Common - protein of unknown function DUF214 Acid_1768 61 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622495 Common - von Willebrand factor, type A Acid_3393 31 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 116624371 Common - DoxX Acid_5292 3 None None None 116622908 Nonpathogen - hypothetical protein Acid_3809 1 None None None 116626214 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Acid_7174 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 116621588 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_2470 14 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116620523 Common - transport-associated Acid_1401 10 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 116623183 Common - pseudouridine synthase Acid_4090 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 116623429 Nonpathogen - hypothetical protein Acid_4338 1 None None None 116625011 Common - protein of unknown function DUF303, acetylesterase putative Acid_5941 19 None None None 116625398 Nonpathogen - hypothetical protein Acid_6343 2 COG3258 COG3258, Cytochrome c Energy production and conversion 116621006 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Acid_1887 104 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116624184 Common - ribosomal protein L30 Acid_5100 69 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 116620421 Common - Tetratricopeptide TPR_2 repeat protein Acid_1298 179 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 116621387 Common - alpha/beta hydrolase fold Acid_2268 53 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 116622487 Nonpathogen - hypothetical protein Acid_3385 1 None None None 116625754 Common - RNA modification enzyme, MiaB family Acid_6704 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 116620387 Common - Alcohol dehydrogenase, zinc-binding domain protein Acid_1264 213 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 116621497 Common - Tetratricopeptide TPR_2 repeat protein Acid_2379 51 COG4995 COG4995, Uncharacterized protein conserved in bacteria Function unknown 116626052 Common - filamentation induced by cAMP protein Fic Acid_7010 59 COG3177 COG3177, Uncharacterized conserved protein Function unknown 116623782 Nonpathogen - hypothetical protein Acid_4694 1 None None None 116620240 Common - sodium:dicarboxylate symporter Acid_1117 158 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 116626937 Nonpathogen - hypothetical protein Acid_7914 2 None None None 116624729 Nonpathogen - cytochrome c family protein Acid_5653 4 None None None 116626573 Common - putative sulfite oxidase subunit YedY Acid_7536 108 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 116620749 Nonpathogen - hypothetical protein Acid_1630 1 None None None 116622466 Nonpathogen - hypothetical protein Acid_3364 1 None None None 116625146 Common - hypothetical protein Acid_6084 8 None None None 116624613 Common - Periplasmic component of the Tol biopolymer transport system-like protein Acid_5537 117 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116625382 Common - sterol desaturase Acid_6327 72 COG3000 ERG3, Sterol desaturase Lipid metabolism 116623856 Common - aminoglycoside phosphotransferase Acid_4768 6 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 116624880 Nonpathogen - hypothetical protein Acid_5804 1 None None None 116622433 Common - oxidoreductase domain protein Acid_3331 146 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116626544 Common - protein of unknown function DUF214 Acid_7507 21 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116619552 Common - transcriptional regulator, TetR family Acid_0413 114 COG1309 AcrR, Transcriptional regulator Transcription 116626325 Common - integral membrane sensor signal transduction histidine kinase Acid_7285 132 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 116623416 Common - hypothetical protein Acid_4325 25 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116623809 Common - transcriptional regulator, PadR-like family Acid_4721 6 COG1695 COG1695, Predicted transcriptional regulators Transcription 116626366 Nonpathogen - hypothetical protein Acid_7326 5 None None None 116621111 Common - beta-lactamase Acid_1992 51 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116620218 Common - putative transmembrane anti-sigma factor Acid_1095 12 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 116620774 Common - protein of unknown function DUF214 Acid_1655 61 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 116624086 Common - beta-lactamase Acid_5000 136 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116620020 Nonpathogen - CRISPR-associated protein, Csm2 family Acid_0892 1 COG1421 COG1421, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 116622099 Common - hypothetical protein Acid_2986 19 None None None 116620272 Common - Pyrrolo-quinoline quinone Acid_1149 59 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116623902 Nonpathogen - hypothetical protein Acid_4814 2 None None None 116625555 Common - Triose-phosphate isomerase Acid_6502 224 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 116624409 Common - hypothetical protein Acid_5331 4 COG4099 COG4099, Predicted peptidase General function prediction only 116624874 Common - acriflavin resistance protein Acid_5798 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116624865 Nonpathogen - hypothetical protein Acid_5789 1 None None None 116620392 Common - twin-arginine translocation protein, TatA/E family subunit Acid_1269 43 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 116622027 Common - Carboxymuconolactone decarboxylase Acid_2912 104 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 116619304 Common - hypothetical protein Acid_0160 4 None None None 116625006 Common - Xylose isomerase domain protein TIM barrel Acid_5936 7 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116625989 Common - glycosyl transferase, family 2 Acid_6947 161 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 116623135 Common - Heparinase II/III family protein Acid_4041 10 None None None 116620468 Nonpathogen - hypothetical protein Acid_1346 4 None None None 116621248 Common - intracellular protease, PfpI family Acid_2129 140 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 116623672 Nonpathogen - hypothetical protein Acid_4584 1 None None None 116625695 Common - excinuclease ABC, C subunit Acid_6644 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 116623214 Common - hypothetical protein Acid_4121 3 COG4733 COG4733, Phage-related protein, tail component Function unknown 116623720 Common - GDP-mannose 4,6-dehydratase Acid_4632 223 COG1089 Gmd, GDP-D-mannose dehydratase Cell envelope biogenesis, outer membrane 116620350 Common - Cna B domain protein Acid_1227 23 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116620942 Common - hypothetical protein Acid_1823 21 None None None 116622836 Common - hypothetical protein Acid_3736 8 COG4932 COG4932, Predicted outer membrane protein Cell envelope biogenesis, outer membrane 116624461 Common - hypothetical protein Acid_5383 25 None None None 116621538 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Acid_2420 119 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 116623155 Common - hypothetical protein Acid_4061 14 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 116622975 Common - serine O-acetyltransferase Acid_3878 197 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 116619396 Common - p-hydroxycinnamoyl CoA hydratase/lyase Acid_0255 182 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 116620359 Nonpathogen - hypothetical protein Acid_1236 1 None None None 116622861 Common - WD-40 repeat protein Acid_3762 52 COG2319 COG2319, FOG: WD40 repeat General function prediction only 116622451 Nonpathogen - hypothetical protein Acid_3349 1 None None None 116619858 Common - outer membrane efflux protein Acid_0730 70 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116626225 Nonpathogen - YD repeat protein Acid_7185 6 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116626381 Common - L-aspartate oxidase Acid_7341 226 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 116623150 Common - class II aldolase/adducin family protein Acid_4056 142 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 116623851 Nonpathogen - hypothetical protein Acid_4763 1 None None None 116620107 Common - hypothetical protein Acid_0980 7 None None None 116620369 Nonpathogen - hypothetical protein Acid_1246 5 None None None 116622850 Common - ABC transporter related Acid_3750 247 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116623179 Common - anion transporter Acid_4086 99 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 116625042 Common - peptidase U62, modulator of DNA gyrase Acid_5972 116 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 116625485 Common - nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein Acid_6431 169 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 116626826 Common - proteinase inhibitor I11, ecotin Acid_7799 21 COG4574 Eco, Serine protease inhibitor ecotin General function prediction only 116625517 Common - Tetratricopeptide TPR_2 repeat protein Acid_6464 35 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116620098 Common - LemA family protein Acid_0971 131 COG1704 LemA, Uncharacterized conserved protein Function unknown 116620506 Nonpathogen - hypothetical protein Acid_1384 3 None None None 116621608 Common - beta-lactamase Acid_2490 152 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116622018 Common - (2Fe-2S)-binding domain protein Acid_2903 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 116619870 Common - hypothetical protein Acid_0742 12 None None None 116626150 Common - Alpha-L-fucosidase Acid_7109 30 COG3669 COG3669, Alpha-L-fucosidase Carbohydrate transport and metabolism 116619847 Common - Integrase, catalytic region Acid_0719 77 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 116620165 Common - small GTP-binding protein Acid_1038 241 COG1160 COG1160, Predicted GTPases General function prediction only 116623921 Nonpathogen - hypothetical protein Acid_4833 1 None None None 116620403 Nonpathogen - TonB family protein Acid_1280 13 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 116624811 Common - ABC transporter related Acid_5735 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116619611 Nonpathogen - hypothetical protein Acid_0472 2 None None None 116623660 Nonpathogen - hypothetical protein Acid_4572 7 None None None 116625121 Nonpathogen - hypothetical protein Acid_6058 1 None None None 116623899 Nonpathogen - hypothetical protein Acid_4811 2 None None None 116624397 Common - NADH-quinone oxidoreductase, B subunit Acid_5318 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 116626470 Common - peptidase M24 Acid_7433 247 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 116626789 Common - putative methyltransferase Acid_7762 213 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 116619594 Nonpathogen - hypothetical protein Acid_0455 9 None None None 116620038 Common - isochorismatase hydrolase Acid_0910 111 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 116621654 Common - transcriptional regulator, LuxR family Acid_2536 154 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116624593 Common - Alpha/beta hydrolase fold-3 domain protein Acid_5517 116 COG0657 Aes, Esterase/lipase Lipid metabolism 116619362 Common - malto-oligosyltrehalose synthase Acid_0220 84 COG3280 TreY, Maltooligosyl trehalose synthase Carbohydrate transport and metabolism 116619430 Common - SNO glutamine amidotransferase Acid_0289 85 COG0311 PDX2, Predicted glutamine amidotransferase involved in pyridoxine biosynthesis Coenzyme metabolism 116621806 Nonpathogen - hypothetical protein Acid_2688 1 None None None 116620768 Common - capsular polysaccharide biosynthesis protein Acid_1649 134 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 116619892 Nonpathogen - hypothetical protein Acid_0764 1 COG5336 COG5336, Uncharacterized protein conserved in bacteria Function unknown 116621753 Common - major facilitator superfamily MFS_1 Acid_2635 195 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116624739 Common - iojap-like protein Acid_5663 190 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 116623371 Common - hypothetical protein Acid_4280 25 COG3503 COG3503, Predicted membrane protein Function unknown 116624642 Nonpathogen - zinc/iron permease Acid_5566 5 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 116619494 Common - Transketolase, central region Acid_0353 207 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 116624035 Nonpathogen - hypothetical protein Acid_4949 1 None None None 116626413 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Acid_7375 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 116622713 Nonpathogen - hypothetical protein Acid_3612 5 None None None 116622801 Common - putative RNA polymerase, sigma-24 subunit, ECF subfamily Acid_3701 47 COG4941 COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain Transcription 116623883 Common - protein of unknown function DUF214 Acid_4795 110 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116625163 Nonpathogen - hypothetical protein Acid_6106 1 None None None 116622346 Common - phosphatidate cytidylyltransferase Acid_3240 215 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 116621689 Common - hypothetical protein Acid_2571 69 COG1837 COG1837, Predicted RNA-binding protein (contains KH domain) General function prediction only 116622584 Common - integral membrane sensor signal transduction histidine kinase Acid_3482 144 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 116620441 Common - transposase IS116/IS110/IS902 family protein Acid_1319 87 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116620375 Common - OmpA/MotB domain protein Acid_1252 100 COG1360 MotB, Flagellar motor protein Cell motility and secretion 116623096 Nonpathogen - hypothetical protein Acid_4000 1 None None None 116619879 Nonpathogen - protein of unknown function DUF214 Acid_0751 9 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623877 Common - chaperonin Cpn10 Acid_4789 214 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 116620454 Common - microcompartments protein Acid_1332 46 COG4577 CcmK, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 116621766 Common - putative esterase Acid_2648 26 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 116620057 Common - Protein of unknown function DUF1592 Acid_0929 7 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 116623826 Common - Methyltransferase type 11 Acid_4738 172 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116622560 Common - binding-protein-dependent transport systems inner membrane component Acid_3458 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 116626565 Common - NAD-dependent epimerase/dehydratase Acid_7528 82 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116626198 Common - glycosyl transferase, family 2 Acid_7158 217 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116624554 Common - integral membrane sensor signal transduction histidine kinase Acid_5478 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116622874 Nonpathogen - hypothetical protein Acid_3775 7 None None None 116619182 Common - Lactaldehyde dehydrogenase Acid_0037 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 116621671 Nonpathogen - hypothetical protein Acid_2553 1 None None None 116623846 Nonpathogen - hypothetical protein Acid_4758 2 None None None 116623231 Common - hypothetical protein Acid_4138 6 None None None 116625360 Common - sulfatase Acid_6305 38 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116623787 Common - transcriptional regulator, PadR-like family Acid_4699 16 COG1695 COG1695, Predicted transcriptional regulators Transcription 116626877 Common - Creatininase Acid_7853 85 COG1402 COG1402, Uncharacterized protein, putative amidase General function prediction only 116621185 Common - hypothetical protein Acid_2066 2 None None None 116623979 Common - ABC transporter related Acid_4891 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 116619634 Nonpathogen - hypothetical protein Acid_0495 5 None None None 116621094 Nonpathogen - type I phosphodiesterase/nucleotide pyrophosphatase Acid_1975 24 COG3379 COG3379, Uncharacterized conserved protein Function unknown 116619540 Common - Polysulphide reductase, NrfD Acid_0399 31 COG5557 COG5557, Polysulphide reductase Energy production and conversion 116622180 Nonpathogen - hypothetical protein Acid_3072 4 COG3828 COG3828, Uncharacterized protein conserved in bacteria Function unknown 116626633 Common - hypothetical protein Acid_7598 9 None None None 116622813 Common - TonB-dependent receptor Acid_3713 24 None None None 116623174 Common - hypothetical protein Acid_4081 30 COG2984 COG2984, ABC-type uncharacterized transport system, periplasmic component General function prediction only 116621616 Common - protein of unknown function DUF403 Acid_2498 82 COG2307 COG2307, Uncharacterized protein conserved in bacteria Function unknown 116622288 Common - Uridine kinase Acid_3182 96 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 116622635 Nonpathogen - hypothetical protein Acid_3534 1 None None None 116623893 Common - LmbE family protein Acid_4805 49 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 116620290 Common - beta-ketoacyl synthase Acid_1167 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116626627 Common - ASPIC/UnbV domain protein Acid_7590 27 None None None 116622946 Common - ABC transporter related Acid_3848 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 116624328 Nonpathogen - hypothetical protein Acid_5246 2 None None None 116621068 Common - FG-GAP repeat protein Acid_1949 9 None None None 116623890 Common - hypothetical protein Acid_4802 37 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 116622033 Nonpathogen - hypothetical protein Acid_2918 5 None None None 116619599 Nonpathogen - H+-transporting two-sector ATPase, B/B' subunit Acid_0460 3 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 116619258 Common - NADH-quinone oxidoreductase, chain G Acid_0114 202 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 116621746 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Acid_2628 103 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116621926 Common - NUDIX hydrolase Acid_2811 50 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 116620068 Common - protein of unknown function DUF891 Acid_0940 34 COG4679 COG4679, Phage-related protein Function unknown 116624199 Common rplB 50S ribosomal protein L2 Acid_5115 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 116620365 Common - protein of unknown function DUF1680 Acid_1242 31 COG3533 COG3533, Uncharacterized protein conserved in bacteria Function unknown 116624915 Common - RNA methyltransferase, TrmA family Acid_5841 198 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 116626111 Common - Redoxin domain protein Acid_7069 169 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116625773 Common - phosphoribosylglycinamide formyltransferase Acid_6723 222 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 116626708 Common - serine/threonine protein kinase Acid_7680 152 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116620133 Nonpathogen - hypothetical protein Acid_1006 1 None None None 116625283 Common - dTDP-glucose 4,6-dehydratase Acid_6228 232 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 116626403 Nonpathogen - hypothetical protein Acid_7365 3 None None None 116620253 Common - TonB-dependent receptor Acid_1130 16 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116624663 Common - hypothetical protein Acid_5587 3 None None None 116622569 Nonpathogen - hypothetical protein Acid_3467 1 None None None 116620286 Nonpathogen - hypothetical protein Acid_1163 1 None None None 116626508 Common - hypothetical protein Acid_7471 14 COG5373 COG5373, Predicted membrane protein Function unknown 116621941 Common - histidine triad (HIT) protein Acid_2826 205 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 116623211 Nonpathogen - hypothetical protein Acid_4118 1 None None None 116620031 Common - ribosome recycling factor Acid_0903 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 116623244 Common - acriflavin resistance protein Acid_4151 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116619561 Nonpathogen - hypothetical protein Acid_0422 2 None None None 116625825 Nonpathogen - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_6776 4 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 116625620 Common - Beta-N-acetylhexosaminidase Acid_6569 59 COG3525 Chb, N-acetyl-beta-hexosaminidase Carbohydrate transport and metabolism 116620319 Nonpathogen - hypothetical protein Acid_1196 1 None None None 116620985 Common - Xylose isomerase domain protein TIM barrel Acid_1866 3 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116625651 Nonpathogen - hypothetical protein Acid_6600 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116622395 Nonpathogen - hypothetical protein Acid_3289 1 None None None 116622903 Nonpathogen - hypothetical protein Acid_3804 1 None None None 116624369 Nonpathogen - hypothetical protein Acid_5290 1 None None None 116625614 Common - hydrogenase accessory protein HypB Acid_6563 153 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 116625842 Common - glycosyl hydrolase, BNR repeat Acid_6795 46 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116620141 Nonpathogen - hypothetical protein Acid_1014 1 None None None 116623961 Common - Transglycosylase-associated protein Acid_4873 41 COG2261 COG2261, Predicted membrane protein Function unknown 116620978 Common - biotin/lipoyl attachment domain-containing protein Acid_1859 186 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 116625601 Nonpathogen - UTP--glucose-1-phosphate uridylyltransferase-like protein Acid_6550 2 COG4284 COG4284, UDP-glucose pyrophosphorylase Carbohydrate transport and metabolism 116619730 Common - multi-sensor hybrid histidine kinase Acid_0595 210 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116625430 Common - Thiamine-phosphate diphosphorylase Acid_6375 181 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 116620673 Common - NHL repeat containing protein Acid_1553 51 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116623735 Common - glycosyl transferase, family 2 Acid_4647 7 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116623507 Common - hypothetical protein Acid_4417 4 None None None 116622135 Common - glycosyl transferase, group 1 Acid_3023 94 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116621315 Common - signal transduction histidine kinase, LytS Acid_2196 115 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 116626376 Common - FAD dependent oxidoreductase Acid_7336 101 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 116622532 Common - SMP-30/Gluconolaconase/LRE domain protein Acid_3430 69 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116625719 Common - glycoside hydrolase family 2, sugar binding Acid_6668 74 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 116621127 Common - hypothetical protein Acid_2008 10 None None None 116620487 Common - hypothetical protein Acid_1365 13 None None None 116625807 Common - fatty acid/phospholipid synthesis protein PlsX Acid_6758 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 116621619 Common - hypothetical protein Acid_2501 191 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 116623861 Common - protein of unknown function DUF214 Acid_4773 152 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116625424 Common tnaA tryptophanase Acid_6369 44 COG3033 TnaA, Tryptophanase Amino acid transport and metabolism 116622573 Common - maturase-like protein Acid_3471 46 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 116625458 Nonpathogen - TRASH domain protein Acid_6403 3 None None None 116626610 Common - TonB-dependent receptor Acid_7573 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116623325 Nonpathogen - hypothetical protein Acid_4234 2 None None None 116623130 Common - Spore coat assembly protein-like protein Acid_4036 17 COG5337 CotH, Spore coat assembly protein Cell envelope biogenesis, outer membrane 116626018 Common - hypothetical protein Acid_6976 8 None None None 116620190 Nonpathogen - hypothetical protein Acid_1063 4 None None None 116623545 Common - Alcohol dehydrogenase, zinc-binding domain protein Acid_4455 115 COG2130 COG2130, Putative NADP-dependent oxidoreductases General function prediction only 116619414 Nonpathogen - hypothetical protein Acid_0273 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116625950 Common - Cytochrome-c oxidase Acid_6908 173 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 116619814 Nonpathogen - hypothetical protein Acid_0684 2 None None None 116619805 Nonpathogen - hypothetical protein Acid_0675 1 None None None 116620805 Common - Methionine adenosyltransferase Acid_1686 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 116620049 Common - hypothetical protein Acid_0921 27 COG3581 COG3581, Uncharacterized protein conserved in bacteria Function unknown 116622475 Common - NAD(P) transhydrogenase, beta subunit Acid_3373 123 COG1282 PntB, NAD/NADP transhydrogenase beta subunit Energy production and conversion 116626205 Common - GCN5-related N-acetyltransferase Acid_7165 84 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 116625561 Nonpathogen - hypothetical protein Acid_6508 2 None None None 116624301 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_5219 13 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116625490 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Acid_6436 15 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116620251 Common - serine/threonine protein kinase with TPR repeats Acid_1128 156 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116619337 Common - TonB-dependent receptor, plug Acid_0194 28 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116626241 Common - peptidase M16 domain protein Acid_7201 200 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 116620874 Common - two component transcriptional regulator, LuxR family Acid_1755 218 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116621823 Nonpathogen - Abortive infection protein Acid_2705 2 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 116619907 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Acid_0779 1 None None None 116626352 Common - cell cycle protein Acid_7312 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 116623238 Common - hypothetical protein Acid_4145 3 None None None 116622962 Common - transketolase Acid_3864 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 116624886 Common - hypothetical protein Acid_5810 58 COG3214 COG3214, Uncharacterized protein conserved in bacteria Function unknown 116622086 Nonpathogen - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_2973 10 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 116620491 Nonpathogen - Propeptide, peptidase M4 and M36 Acid_1369 6 COG3227 LasB, Zinc metalloprotease (elastase) Amino acid transport and metabolism 116626217 Common - protein of unknown function DUF214 Acid_7177 145 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116626886 Common - sodium/hydrogen exchanger Acid_7862 188 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 116625739 Common - putative phosphohistidine phosphatase, SixA Acid_6689 65 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 116624306 Common - Activator of Hsp90 ATPase 1 family protein Acid_5224 49 COG3832 COG3832, Uncharacterized conserved protein Function unknown 116624999 Common - Radical SAM domain protein Acid_5929 127 COG1964 COG1964, Predicted Fe-S oxidoreductases General function prediction only 116626185 Common - sigma54 specific transcriptional regulator, Fis family Acid_7145 172 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116620714 Common - transcriptional regulator, GntR family Acid_1594 136 COG1725 COG1725, Predicted transcriptional regulators Transcription 116623348 Nonpathogen - hypothetical protein Acid_4257 1 None None None 116621336 Common - Rhomboid family protein Acid_2217 162 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 116620117 Nonpathogen - hypothetical protein Acid_0990 2 None None None 116622790 Common - TonB-dependent receptor, plug Acid_3690 18 None None None 116626608 Common - WD40 domain protein beta Propeller Acid_7571 151 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116620556 Nonpathogen - hypothetical protein Acid_1434 1 COG2968 COG2968, Uncharacterized conserved protein Function unknown 116621366 Common - NAD-dependent epimerase/dehydratase Acid_2247 220 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116619231 Common - alpha/beta hydrolase fold Acid_0086 87 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 116623969 Common - lipopolysaccharide biosynthesis Acid_4881 172 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 116625559 Nonpathogen - hypothetical protein Acid_6506 3 None None None 116625179 Common - putative transposase Acid_6124 53 None None None 116620331 Common - serine/threonine protein kinase with TPR repeats Acid_1208 164 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116620863 Common - Cna B domain protein Acid_1744 23 None None None 116626451 Nonpathogen - hypothetical protein Acid_7413 3 None None None 116619244 Nonpathogen - hypothetical protein Acid_0100 2 None None None 116625571 Common - homogentisate 1,2-dioxygenase Acid_6518 47 COG3508 HmgA, Homogentisate 1,2-dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 116619646 Common - hypothetical protein Acid_0507 86 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 116619900 Common - peptidase M1, membrane alanine aminopeptidase Acid_0772 92 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 116625675 Common - Radical SAM domain protein Acid_6624 85 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116620755 Nonpathogen - hypothetical protein Acid_1636 1 None None None 116622009 Common - glycoside hydrolase family 2, TIM barrel Acid_2894 76 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 116621133 Nonpathogen - hypothetical protein Acid_2014 2 None None None 116620473 Common - putative secreted protein Acid_1351 9 None None None 116620268 Common - protein of unknown function DUF1549 Acid_1145 5 None None None 116623768 Common - hypothetical protein Acid_4680 14 COG3189 COG3189, Uncharacterized conserved protein Function unknown 116620535 Common - type II secretion system protein Acid_1413 83 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 116625220 Common - DSBA oxidoreductase Acid_6165 120 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 116623675 Common - Lytic transglycosylase, catalytic Acid_4587 136 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 116623802 Common - Thioesterase Acid_4714 59 COG3208 GrsT, Predicted thioesterase involved in non-ribosomal peptide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 116625710 Common - PfkB domain protein Acid_6659 57 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 116622139 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_3027 160 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 116622777 Common - translation elongation factor P Acid_3676 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 116626666 Common - hypothetical protein Acid_7635 8 None None None 116619810 Common - methylmalonate-semialdehyde dehydrogenase Acid_0680 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 116625599 Common - protein of unknown function DUF1501 Acid_6548 5 COG4102 COG4102, Uncharacterized protein conserved in bacteria Function unknown 116624765 Common - proton-translocating NADH-quinone oxidoreductase, chain M Acid_5689 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 116619285 Common - superoxide dismutase, copper/zinc binding Acid_0141 87 COG2032 SodC, Cu/Zn superoxide dismutase Inorganic ion transport and metabolism 116622110 Common - short-chain dehydrogenase/reductase SDR Acid_2997 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 116619888 Common - PAS/PAC sensor hybrid histidine kinase Acid_0760 222 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116622538 Nonpathogen - hypothetical protein Acid_3436 2 None None None 116621597 Common - ABC transporter related Acid_2479 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116622215 Common - malate synthase Acid_3107 77 COG2225 AceB, Malate synthase Energy production and conversion 116625454 Common - PDZ/DHR/GLGF domain protein Acid_6399 220 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 116624129 Common - Xylose isomerase domain protein TIM barrel Acid_5045 31 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116622022 Common - NHL repeat containing protein Acid_2907 94 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 116623721 Common - membrane protein-like protein Acid_4633 8 COG4713 COG4713, Predicted membrane protein Function unknown 116620081 Common - metallophosphoesterase Acid_0953 59 COG0622 COG0622, Predicted phosphoesterase General function prediction only 116626046 Nonpathogen - hypothetical protein Acid_7004 2 None None None 116626486 Nonpathogen - hypothetical protein Acid_7449 1 COG3951 COG3951, Rod binding protein Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 116625992 Common - acriflavin resistance protein Acid_6950 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116622489 Common - hypothetical protein Acid_3387 17 None None None 116620596 Common - Redoxin domain protein Acid_1475 11 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116620827 Common - hypothetical protein Acid_1708 23 COG5207 UBP14, Isopeptidase T Posttranslational modification, protein turnover, chaperones 116620926 Nonpathogen - PDZ/DHR/GLGF domain protein Acid_1807 2 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 116621727 Nonpathogen - hypothetical protein Acid_2609 2 None None None 116622230 Common - putative heme-binding protein Acid_3123 20 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 116620305 Common - Aromatic-L-amino-acid decarboxylase Acid_1182 87 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 116623616 Nonpathogen - protein of unknown function DUF214 Acid_4526 12 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 116622422 Nonpathogen - hypothetical protein Acid_3319 1 None None None 116623605 Common - ABC transporter related Acid_4515 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116624268 Common - ABC transporter related Acid_5186 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 116624791 Nonpathogen - hypothetical protein Acid_5715 1 None None None 116619969 Common - Protein of unknown function DUF1592 Acid_0841 16 COG3748 COG3748, Predicted membrane protein Function unknown 116621227 Common - Tetratricopeptide TPR_2 repeat protein Acid_2108 73 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116623307 Nonpathogen - hypothetical protein Acid_4214 2 None None None 116623445 Common - Alg9 family protein mannosyltransferase Acid_4354 6 COG4745 COG4745, Predicted membrane-bound mannosyltransferase Posttranslational modification, protein turnover, chaperones 116623814 Common - peptidase C45, acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Acid_4726 9 None None None 116620583 Common - signal transduction histidine kinase, LytS Acid_1462 105 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 116621794 Common - Methionine synthase, vitamin-B12 independent Acid_2676 136 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 116625172 Common - amidase Acid_6116 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 116620041 Common - lipoate-protein ligase B Acid_0913 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 116620103 Common - hypothetical protein Acid_0976 19 None None None 116620177 Common - hypothetical protein Acid_1050 19 None None None 116620817 Common - type III restriction enzyme, res subunit Acid_1698 148 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 116619981 Common - ABC-2 type transporter Acid_0853 55 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116623043 Common - protein of unknown function DUF490 Acid_3947 65 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 116623266 Common - hypothetical protein Acid_4173 22 None None None 116619528 Common - aldo/keto reductase Acid_0387 190 COG1453 COG1453, Predicted oxidoreductases of the aldo/keto reductase family General function prediction only 116626559 Common - FHA domain containing protein Acid_7522 2 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 116622756 Common - Cl- channel, voltage-gated family protein Acid_3655 158 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 116623565 Common - TonB-dependent receptor Acid_4475 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116624519 Nonpathogen - glycosyl transferase, family 39 Acid_5443 3 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116624708 Common - protein of unknown function DUF81 Acid_5632 45 COG0730 COG0730, Predicted permeases General function prediction only 116622311 Common - FAD linked oxidase domain protein Acid_3205 50 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 116621207 Common - Alpha/beta hydrolase fold-3 domain protein Acid_2088 85 COG0657 Aes, Esterase/lipase Lipid metabolism 116622970 Nonpathogen - hypothetical protein Acid_3873 1 None None None 116626305 Common - pseudouridine synthase, RluA family Acid_7265 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 116626675 Common - putative transposase Acid_7645 33 None None None 116621251 Common - short-chain dehydrogenase/reductase SDR Acid_2132 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116624236 Nonpathogen - hypothetical protein Acid_5153 1 None None None 116624042 Common - peptidase S9, prolyl oligopeptidase active site domain protein Acid_4956 113 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116621987 Common - hypothetical protein Acid_2872 13 None None None 116624078 Common - outer membrane efflux protein Acid_4992 105 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116626304 Nonpathogen - hypothetical protein Acid_7264 1 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 116624492 Nonpathogen - periplasmic protein-like protein Acid_5414 5 COG3900 COG3900, Predicted periplasmic protein Function unknown 116625944 Nonpathogen - K+ channel, pore region Acid_6902 3 None None None 116626790 Common - ATP-dependent DNA helicase RecG Acid_7763 222 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 116626439 Common - succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family Acid_7401 30 None None None 116620160 Common - protein of unknown function DUF214 Acid_1033 220 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 116621720 Nonpathogen - tetratricopeptide repeat protein Acid_2602 5 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116625473 Common - peptidase M16 domain protein Acid_6419 159 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 116621326 Common - signal peptidase I Acid_2207 207 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 116624712 Nonpathogen - hypothetical protein Acid_5636 1 None None None 116622413 Common - putative transposase Acid_3308 34 None None None 116624849 Nonpathogen - hypothetical protein Acid_5773 1 None None None 116625078 Nonpathogen - hypothetical protein Acid_6009 1 None None None 116621124 Nonpathogen - hypothetical protein Acid_2005 1 None None None 116621972 Common hppA membrane-bound proton-translocating pyrophosphatase Acid_2857 98 COG3808 OVP1, Inorganic pyrophosphatase Energy production and conversion 116625497 Nonpathogen - hypothetical protein Acid_6444 1 None None None 116626920 Common - hypothetical protein Acid_7897 8 None None None 116626082 Common - DNA mismatch repair protein MutL Acid_7040 191 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 116620234 Common - ferric uptake regulator, Fur family Acid_1111 142 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 116622726 Common - Tetratricopeptide TPR_2 repeat protein Acid_3625 154 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116622894 Nonpathogen - hypothetical protein Acid_3795 1 COG5305 COG5305, Predicted membrane protein Function unknown 116621084 Common - Tetratricopeptide TPR_4 Acid_1965 103 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116620153 Common - D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase Acid_1026 102 COG2027 DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) Cell envelope biogenesis, outer membrane 116626779 Common - type II and III secretion system protein Acid_7752 137 COG4964 CpaC, Flp pilus assembly protein, secretin CpaC Intracellular trafficking and secretion 116622982 Nonpathogen - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_3885 2 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 116619753 Common - glycosyl transferase, family 2 Acid_0619 186 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116621051 Common - Quinoprotein glucose dehydrogenase Acid_1932 65 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116625258 Common - acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase Acid_6203 147 COG1043 LpxA, Acyl- acyl carrier protein 116621590 Common - Methyltransferase type 11 Acid_2472 149 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116626160 Common - glycosyl transferase, family 2 Acid_7120 175 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116620321 Nonpathogen - hypothetical protein Acid_1198 3 None None None 116619222 Common - Osmosensitive K+ channel His kinase sensor Acid_0077 91 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 116621908 Common - two component transcriptional regulator, LuxR family Acid_2793 212 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116623502 Nonpathogen - hypothetical protein Acid_4412 1 None None None 116621188 Common - PfkB domain protein Acid_2069 93 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 116620636 Nonpathogen - hypothetical protein Acid_1515 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116622418 Common - RNA-directed DNA polymerase (Reverse transcriptase) Acid_3314 96 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 116626515 Common - ABC transporter related Acid_7478 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 116620642 Nonpathogen - hypothetical protein Acid_1521 1 None None None 116625185 Common - integral membrane sensor signal transduction histidine kinase Acid_6130 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116620788 Common - virulence-associated E family protein Acid_1669 32 COG5545 COG5545, Predicted P-loop ATPase and inactivated derivatives General function prediction only 116622593 Common - Tetratricopeptide TPR_2 repeat protein Acid_3491 30 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116624008 Common - Methyltransferase type 11 Acid_4920 14 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116625275 Nonpathogen - hypothetical protein Acid_6220 1 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 116619581 Nonpathogen - hypothetical protein Acid_0442 5 COG2128 COG2128, Uncharacterized conserved protein Function unknown 116622160 Nonpathogen - TonB-dependent receptor Acid_3052 2 None None None 116621575 Common - protein of unknown function DUF1080 Acid_2457 8 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 116622807 Nonpathogen - hypothetical protein Acid_3707 2 None None None 116625231 Common - ABC transporter related Acid_6176 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 116625789 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Acid_6739 156 COG0388 COG0388, Predicted amidohydrolase General function prediction only 116619439 Common - exodeoxyribonuclease VII, large subunit Acid_0298 205 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 116619401 Common - Tannase and feruloyl esterase Acid_0260 20 None None None 116624607 Nonpathogen - hypothetical protein Acid_5531 1 None None None 116625977 Common - glycosyltransferase 36 Acid_6935 34 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116619844 Nonpathogen - hypothetical protein Acid_0714 1 None None None 116624011 Common - Rhodanese domain protein Acid_4923 125 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 116620216 Common - protein of unknown function DUF37 Acid_1091 180 COG0759 COG0759, Uncharacterized conserved protein Function unknown 116620336 Common - ATP-dependent Clp protease adaptor protein ClpS Acid_1213 4 COG2127 COG2127, Uncharacterized conserved protein Function unknown 116621638 Common - phage integrase family protein Acid_2520 181 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116621872 Nonpathogen - hypothetical protein Acid_2755 2 None None None 116622670 Nonpathogen - hypothetical protein Acid_3569 1 None None None 116622640 Common - UspA domain protein Acid_3539 90 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 116625999 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_6957 88 COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins Amino acid transport and metabolism / General function prediction only 116620174 Common - conserved hypothetical cytosolic protein Acid_1047 20 COG4924 COG4924, Uncharacterized protein conserved in bacteria Function unknown 116625816 Common - Pyrrolo-quinoline quinone Acid_6767 60 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116619169 Common - serine/threonine protein kinase Acid_0024 209 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116625666 Nonpathogen - hypothetical protein Acid_6615 1 None None None 116619927 Common - signal peptidase I Acid_0799 206 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 116619354 Common - Tetratricopeptide TPR_2 repeat protein Acid_0212 56 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116626807 Common - general secretion pathway protein G Acid_7780 79 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 116619421 Common - glycosyl transferase, family 2 Acid_0280 189 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116622440 Nonpathogen - hydrolase of the HAD superfamily-like protein Acid_3338 1 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 116625463 Common - hypothetical protein Acid_6408 4 None None None 116625394 Nonpathogen - hypothetical protein Acid_6339 9 None None None 116622833 Nonpathogen - hypothetical protein Acid_3733 1 None None None 116619799 Common - 40-residue YVTN family beta-propeller repeat protein Acid_0669 77 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116623076 Common - 2-dehydro-3-deoxyglucarate aldolase Acid_3980 74 COG3836 HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase Carbohydrate transport and metabolism 116619340 Common - hypothetical protein Acid_0197 8 None None None 116626248 Common - protein of unknown function DUF214 Acid_7208 152 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116621479 Nonpathogen - hypothetical protein Acid_2361 1 None None None 116623997 Common - Xylose isomerase domain protein TIM barrel Acid_4909 6 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116626167 Common - hypothetical protein Acid_7127 64 COG1691 COG1691, NCAIR mutase (PurE)-related proteins General function prediction only 116624411 Common - Amidase Acid_5333 220 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 116620512 Nonpathogen - hypothetical protein Acid_1390 1 None None None 116624299 Common - serine/threonine protein kinase Acid_5217 152 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116619656 Common - Cupin 2, conserved barrel domain protein Acid_0517 26 COG4101 COG4101, Predicted mannose-6-phosphate isomerase Carbohydrate transport and metabolism 116624217 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Acid_5133 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 116622075 Common - CsbD family protein Acid_2962 55 COG3237 COG3237, Uncharacterized protein conserved in bacteria Function unknown 116624166 Nonpathogen - hypothetical protein Acid_5082 1 None None None 116623054 Nonpathogen - hypothetical protein Acid_3958 1 None None None 116623287 Nonpathogen - hypothetical protein Acid_4194 1 None None None 116620482 Nonpathogen - hypothetical protein Acid_1360 1 None None None 116624891 Common - response regulator receiver protein Acid_5815 135 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116624734 Nonpathogen - hypothetical protein Acid_5658 4 COG3071 HemY, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 116622117 Common - Inorganic diphosphatase Acid_3005 183 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 116625849 Common - Integrase, catalytic region Acid_6803 46 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 116625688 Common - LmbE family protein Acid_6637 52 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 116620908 Common - PHA accumulation regulator DNA-binding protein Acid_1789 64 COG5394 COG5394, Uncharacterized protein conserved in bacteria Function unknown 116624436 Common - hypothetical protein Acid_5358 7 None None None 116624836 Common - hypothetical protein Acid_5760 20 None None None 116621752 Nonpathogen - hypothetical protein Acid_2634 1 None None None 116621411 Nonpathogen - hypothetical protein Acid_2293 1 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116622187 Common - electron transfer flavoprotein, alpha subunit Acid_3079 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 116624109 Common - serine/threonine protein kinase Acid_5024 196 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116620232 Nonpathogen - hypothetical protein Acid_1109 2 None None None 116624376 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_5297 74 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 116620162 Common - glycosyl transferase, family 2 Acid_1035 202 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116621445 Nonpathogen - hypothetical protein Acid_2327 1 None None None 116620208 Common - protein of unknown function DUF344 Acid_1081 127 COG2326 COG2326, Uncharacterized conserved protein Function unknown 116625896 Common - haloacid dehalogenase, type II Acid_6850 31 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 116622998 Common - oxidoreductase domain protein Acid_3902 148 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116621082 Common - YcfA family protein Acid_1963 16 COG1724 COG1724, Predicted periplasmic or secreted lipoprotein Cell motility and secretion 116623739 Common - glycosyl transferase, group 1 Acid_4651 157 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116621595 Nonpathogen - Peptidoglycan-binding domain 1 protein Acid_2477 2 None None None 116625589 Common - aldehyde dehydrogenase Acid_6538 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 116624116 Common - two component transcriptional regulator, winged helix family Acid_5032 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116621882 Common - TonB-dependent receptor, plug Acid_2765 27 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116623342 Common - glutamate-1-semialdehyde-2,1-aminomutase Acid_4251 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 116624526 Common - phosphoesterase, PA-phosphatase related Acid_5450 5 None None None 116625239 Nonpathogen - hypothetical protein Acid_6184 1 None None None 116623990 Common - hypothetical protein Acid_4902 19 None None None 116626805 Common - general secretory pathway protein E Acid_7778 210 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 116619983 Nonpathogen - hypothetical protein Acid_0855 1 None None None 116622141 Common - ATP dependent DNA ligase Acid_3033 107 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 116623538 Common - argininosuccinate synthase Acid_4448 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 116624658 Common - response regulator receiver protein Acid_5582 210 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 116622624 Common - hypothetical protein Acid_3523 15 None None None 116624614 Common - hypothetical protein Acid_5538 9 COG3828 COG3828, Uncharacterized protein conserved in bacteria Function unknown 116625870 Nonpathogen - hypothetical protein Acid_6824 1 None None None 116623611 Common - Alcohol dehydrogenase, zinc-binding domain protein Acid_4521 173 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 116620504 Nonpathogen - hypothetical protein Acid_1382 2 None None None 116624419 Common - transposase IS116/IS110/IS902 family protein Acid_5341 30 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116623085 Nonpathogen - protein of unknown function DUF362 Acid_3989 11 COG2006 COG2006, Uncharacterized conserved protein Function unknown 116625592 Common - protein of unknown function DUF1549 Acid_6541 5 None None None 116619279 Common - hypothetical protein Acid_0135 17 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116619199 Common - DedA Acid_0054 141 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 116623904 Common - TonB family protein Acid_4816 44 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 116625029 Common - protein of unknown function DUF718 Acid_5959 47 COG3254 COG3254, Uncharacterized conserved protein Function unknown 116625265 Nonpathogen - pilin, type IV, putative Acid_6210 2 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 116623691 Common - hypothetical protein Acid_4603 7 None None None 116621828 Common - Lytic transglycosylase, catalytic Acid_2710 158 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 116619213 Common - MOSC domain containing protein Acid_0068 95 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 116621853 Common - Uncharacterized enzyme involved in inositol metabolism Acid_2736 56 COG3718 IolB, Uncharacterized enzyme involved in inositol metabolism Carbohydrate transport and metabolism 116622709 Common - AMP-dependent synthetase and ligase Acid_3608 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116622991 Common - conserved hypothetical protein 730 Acid_3894 108 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 116621759 Common - fatty acid desaturase Acid_2641 10 COG3239 DesA, Fatty acid desaturase Lipid metabolism 116625324 Common - protein of unknown function DUF214 Acid_6269 138 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 116626041 Common - hypothetical protein Acid_6999 20 None None None 116623777 Nonpathogen - hypothetical protein Acid_4689 1 None None None 116621384 Common - protein of unknown function DUF1501 Acid_2265 5 COG4102 COG4102, Uncharacterized protein conserved in bacteria Function unknown 116621029 Nonpathogen - YbbR family protein Acid_1910 6 COG4856 COG4856, Uncharacterized protein conserved in bacteria Function unknown 116623018 Common - protein of unknown function DUF214 Acid_3922 105 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622386 Common - ribosome small subunit-dependent GTPase A Acid_3280 165 COG1162 COG1162, Predicted GTPases General function prediction only 116624271 Common - hypothetical protein Acid_5189 65 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116622967 Common - oxidoreductase domain protein Acid_3870 157 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116624471 Common - recombination factor protein RarA Acid_5393 234 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 116623032 Common - fructose-1,6-bisphosphate aldolase Acid_3936 173 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 116621355 Common - glycosyl transferase, family 2 Acid_2236 158 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116625183 Nonpathogen - hypothetical protein Acid_6128 2 None None None 116621463 Nonpathogen - hypothetical protein Acid_2345 1 None None None 116626688 Common - dihydropyrimidine dehydrogenase Acid_7660 111 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 116621143 Common - protein of unknown function DUF72 Acid_2024 119 COG1801 COG1801, Uncharacterized conserved protein Function unknown 116624599 Common - DSBA oxidoreductase Acid_5523 112 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 116622159 Nonpathogen - hypothetical protein Acid_3051 1 None None None 116622313 Common - hypothetical protein Acid_3207 49 COG3247 HdeD, Uncharacterized conserved protein Function unknown 116622578 Common - MOSC domain containing protein Acid_3476 148 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 116621019 Common - protein of unknown function DUF1080 Acid_1900 7 COG3164 COG3164, Predicted membrane protein Function unknown 116622647 Common - transcriptional regulator, MarR family Acid_3546 44 COG1846 MarR, Transcriptional regulators Transcription 116621459 Common - LamG domain protein jellyroll fold domain protein Acid_2341 18 None None None 116622257 Common - hypothetical protein Acid_3151 5 None None None 116619944 Common - protein of unknown function DUF6, transmembrane Acid_0816 88 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 116624312 Common - cobyrinic acid a,c-diamide synthase Acid_5230 229 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 116619398 Common - peptidase-like protein Acid_0257 14 COG4099 COG4099, Predicted peptidase General function prediction only 116626513 Common - UDP-N-acetylglucosamine 2-epimerase Acid_7476 154 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 116622121 Common - aldo/keto reductase Acid_3009 156 COG1453 COG1453, Predicted oxidoreductases of the aldo/keto reductase family General function prediction only 116622555 Nonpathogen - hypothetical protein Acid_3453 1 None None None 116623700 Common - D-glutamate deacylase Acid_4612 80 COG3653 COG3653, N-acyl-D-aspartate/D-glutamate deacylase Secondary metabolites biosynthesis, transport, and catabolism 116625798 Nonpathogen - hypothetical protein Acid_6748 1 None None None 116623754 Common - hypothetical protein Acid_4666 11 None None None 116623479 Nonpathogen - hypothetical protein Acid_4389 4 None None None 116624219 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_5135 127 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116621565 Common - hypothetical protein Acid_2447 40 COG4257 Vgb, Streptogramin lyase Defense mechanisms 116622354 Common - response regulator receiver protein Acid_3248 207 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116626031 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit beta Acid_6989 108 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 116621175 Nonpathogen - hypothetical protein Acid_2056 1 None None None 116619956 Common - sugar-phosphate isomerases, RpiB/LacA/LacB family Acid_0828 127 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 116619485 Nonpathogen - hypothetical protein Acid_0344 1 None None None 116621500 Nonpathogen - hypothetical protein Acid_2382 1 None None None 116626743 Nonpathogen - transport-associated Acid_7715 1 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 116620485 Common - AMP-dependent synthetase and ligase Acid_1363 211 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116620692 Nonpathogen - YCII-related protein Acid_1572 1 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 116623024 Common - putative esterase Acid_3928 14 COG4947 COG4947, Uncharacterized protein conserved in bacteria Function unknown 116624453 Nonpathogen - conserved hypothetical protein, putative thiol-disulfide isomerase or thioredoxin Acid_5375 5 None None None 116620297 Common - UvrD/REP helicase Acid_1174 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 116621978 Common - aldo/keto reductase Acid_2863 200 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116626535 Nonpathogen - hypothetical protein Acid_7498 1 None None None 116619463 Common - Ethanolamine utilization protein EutN/carboxysome structural protein Ccml Acid_0322 38 COG4576 CcmL, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 116624636 Common - Tetratricopeptide TPR_2 repeat protein Acid_5560 10 None None None 116622183 Common - MmgE/PrpD family protein Acid_3075 60 COG2079 PrpD, Uncharacterized protein involved in propionate catabolism General function prediction only 116625582 Common - Carboxylesterase, type B Acid_6531 56 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 116620226 Nonpathogen - hypothetical protein Acid_1103 1 None None None 116626737 Common - Tetratricopeptide TPR_2 repeat protein Acid_7709 27 COG0457 NrfG, FOG: TPR repeat General function prediction only 116620914 Nonpathogen - hypothetical protein Acid_1795 1 None None None 116625426 Common - hypothetical protein Acid_6371 8 COG1569 COG1569, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 116624154 Common - signal transduction histidine kinase with CheB and CheR activity Acid_5070 224 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 116620911 Nonpathogen - hypothetical protein Acid_1792 1 None None None 116624921 Common - protein of unknown function DUF214 Acid_5847 67 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620929 Common - ABC transporter related Acid_1810 249 COG1119 ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA Inorganic ion transport and metabolism 116624049 Nonpathogen - hypothetical protein Acid_4963 1 None None None 116621362 Common - thiamine pyrophosphate enzyme TPP binding domain protein Acid_2243 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 116619625 Nonpathogen - hypothetical protein Acid_0486 1 None None None 116622101 Common - putative esterase Acid_2988 28 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 116621429 Common - hypothetical protein Acid_2311 31 COG4704 COG4704, Uncharacterized protein conserved in bacteria Function unknown 116626404 Nonpathogen - hypothetical protein Acid_7366 2 None None None 116626354 Common - phospho-N-acetylmuramoyl-pentapeptide-transferase Acid_7314 224 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 116625345 Common - protein of unknown function DUF1549 Acid_6290 6 None None None 116623634 Common - short-chain dehydrogenase/reductase SDR Acid_4546 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116619408 Common - hypothetical protein Acid_0267 7 COG1554 ATH1, Trehalose and maltose hydrolases (possible phosphorylases) Carbohydrate transport and metabolism 116620922 Common - Methyltransferase type 11 Acid_1803 32 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116622047 Nonpathogen - hypothetical protein Acid_2933 1 COG3554 COG3554, Uncharacterized protein conserved in bacteria Function unknown 116622059 Common - transposase IS66 Acid_2946 53 None None None 116622917 Nonpathogen - hypothetical protein Acid_3818 3 None None None 116626528 Common - glycosyl transferase, family 2 Acid_7491 209 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116622337 Common - Methyltransferase type 12 Acid_3231 28 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116621304 Nonpathogen - hypothetical protein Acid_2185 1 None None None 116622050 Common - putative nitric-oxide reductase Acid_2936 72 COG3256 NorB, Nitric oxide reductase large subunit Inorganic ion transport and metabolism 116620515 Common - transcriptional regulator, Fis family Acid_1393 150 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 116620617 Common - SOS-response transcriptional repressor, LexA Acid_1496 168 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 116620546 Common - hypothetical protein Acid_1424 5 None None None 116624467 Nonpathogen - hypothetical protein Acid_5389 1 None None None 116626843 Nonpathogen - hypothetical protein Acid_7816 2 COG1482 ManA, Phosphomannose isomerase Carbohydrate transport and metabolism 116624474 Common - hypothetical protein Acid_5396 23 None None None 116621470 Common - DNA-directed RNA polymerase, omega subunit Acid_2352 9 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 116625341 Nonpathogen - hypothetical protein Acid_6286 1 None None None 116626845 Nonpathogen - Pyrrolo-quinoline quinone Acid_7818 2 COG1520 COG1520, FOG: WD40-like repeat Function unknown 116623772 Nonpathogen - hypothetical protein Acid_4684 2 COG1297 COG1297, Predicted membrane protein Function unknown 116626751 Common - non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family Acid_7724 235 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 116623003 Common - SNF2-related protein Acid_3907 135 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 116622128 Nonpathogen - hypothetical protein Acid_3016 13 COG4641 COG4641, Uncharacterized protein conserved in bacteria Function unknown 116623261 Common - two component, sigma54 specific, transcriptional regulator, Fis family Acid_4168 210 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116626838 Common - acetyl-CoA carboxylase, biotin carboxyl carrier protein Acid_7811 173 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 116625642 Common - Na+/solute symporter Acid_6591 110 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 116626580 Common - Periplasmic component of the Tol biopolymer transport system-like protein Acid_7543 130 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116623495 Common - hypothetical protein Acid_4405 37 COG5496 COG5496, Predicted thioesterase General function prediction only 116622352 Common - oxidoreductase domain protein Acid_3246 55 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116623224 Nonpathogen - hypothetical protein Acid_4131 1 None None None 116621278 Common - serine phosphatase Acid_2159 118 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 116624665 Common - cytochrome c oxidase, subunit II Acid_5589 141 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 116626930 Nonpathogen - hypothetical protein Acid_7907 1 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116620669 Common - malate dehydrogenase, NAD-dependent Acid_1549 175 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 116625700 Common - putative metal-dependent dipeptidase Acid_6649 23 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 116625376 Nonpathogen - hypothetical protein Acid_6321 1 None None None 116626652 Common - hypothetical protein Acid_7621 4 None None None 116624340 Nonpathogen - cytochrome c, class I Acid_5258 2 COG3474 COG3474, Cytochrome c2 Energy production and conversion 116625039 Common - Pyridoxal-dependent decarboxylase Acid_5969 89 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 116622330 Nonpathogen - hypothetical protein Acid_3224 1 None None None 116619964 Common - formate dehydrogenase, beta subunit Acid_0836 162 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 116623196 Common - Membrane-fusion protein-like protein Acid_4103 107 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 116623804 Common - FkbH like protein Acid_4716 75 COG3882 FkbH, Predicted enzyme involved in methoxymalonyl-ACP biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 116623986 Common - hypothetical protein Acid_4898 30 None None None 116622784 Common - hypothetical protein Acid_3683 2 COG3439 COG3439, Uncharacterized conserved protein Function unknown 116619200 Nonpathogen - hypothetical protein Acid_0055 1 None None None 116619925 Nonpathogen - hypothetical protein Acid_0797 1 None None None 116620352 Common - Methyltransferase type 11 Acid_1229 6 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116624624 Common - hypothetical protein Acid_5548 2 COG3184 COG3184, Uncharacterized protein conserved in bacteria Function unknown 116624974 Nonpathogen - hypothetical protein Acid_5904 1 None None None 116620932 Nonpathogen - hypothetical protein Acid_1813 2 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116622303 Common - YcfA family protein Acid_3197 5 None None None 116626069 Common - hypothetical protein Acid_7027 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116626095 Common - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Acid_7053 152 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 116626778 Nonpathogen - hypothetical protein Acid_7751 1 COG4655 COG4655, Predicted membrane protein Function unknown 116621780 Nonpathogen - hypothetical protein Acid_2662 1 None None None 116621933 Nonpathogen - hypothetical protein Acid_2818 1 None None None 116620968 Common - short-chain dehydrogenase/reductase SDR Acid_1849 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116620699 Common - acriflavin resistance protein Acid_1579 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116624387 Common - protein of unknown function DUF1568 Acid_5308 34 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 116626187 Common - ATPase associated with various cellular activities, AAA_5 Acid_7147 155 COG0714 COG0714, MoxR-like ATPases General function prediction only 116620893 Nonpathogen - hypothetical protein Acid_1774 1 None None None 116621556 Common - adenylosuccinate lyase Acid_2438 240 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 116619786 Common - Transketolase domain protein Acid_0656 221 COG3959 COG3959, Transketolase, N-terminal subunit Carbohydrate transport and metabolism 116625931 Nonpathogen - hypothetical protein Acid_6888 1 None None None 116619416 Common - hypothetical protein Acid_0275 6 None None None 116622852 Common - hypothetical protein Acid_3752 66 COG4301 COG4301, Uncharacterized conserved protein Function unknown 116626322 Nonpathogen - NUDIX hydrolase Acid_7282 1 None None None 116619257 Common - NADH-quinone oxidoreductase, F subunit Acid_0113 168 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 116626460 Common - cytidyltransferase-related domain Acid_7422 119 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 116622148 Nonpathogen - hypothetical protein Acid_3040 1 None None None 116624422 Common - Pyrrolo-quinoline quinone Acid_5344 61 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116621478 Nonpathogen - hypothetical protein Acid_2360 1 None None None 116623581 Common - preprotein translocase, SecA subunit Acid_4491 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 116622825 Common - serine/threonine protein kinase Acid_3725 161 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116622919 Common - sulfatase Acid_3820 83 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116626694 Common - protein of unknown function DUF1501 Acid_7666 5 COG4102 COG4102, Uncharacterized protein conserved in bacteria Function unknown 116624696 Common - Methyltransferase type 11 Acid_5620 58 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116620566 Common - cyclic nucleotide-binding protein Acid_1444 64 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 116626474 Common - glycosyl transferase, family 2 Acid_7437 165 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 116620808 Common - DNA-cytosine methyltransferase Acid_1689 84 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 116620343 Nonpathogen - hypothetical protein Acid_1220 1 None None None 116621709 Nonpathogen - hypothetical protein Acid_2591 1 None None None 116624021 Nonpathogen - hypothetical protein Acid_4933 1 None None None 116626817 Common - dienelactone hydrolase Acid_7790 74 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 116620404 Common - MotA/TolQ/ExbB proton channel Acid_1281 154 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 116619159 Common - phosphoribosylamine--glycine ligase Acid_0014 232 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 116619831 Common - protein of unknown function DUF1080 Acid_0701 15 None None None 116625609 Common - hypothetical protein Acid_6558 7 None None None 116625947 Common - hypothetical protein Acid_6905 27 COG3336 COG3336, Predicted membrane protein Function unknown 116622938 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_3840 13 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116622015 Nonpathogen - hypothetical protein Acid_2900 1 None None None 116626334 Common - Cna B-type protein Acid_7294 24 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116624620 Nonpathogen - hypothetical protein Acid_5544 2 None None None 116622245 Nonpathogen - hypothetical protein Acid_3138 1 None None None 116623973 Common - heavy metal efflux pump, CzcA family Acid_4885 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 116623452 Common - galactose-1-phosphate uridylyltransferase Acid_4361 82 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 116623707 Nonpathogen - amino acid transporters Acid_4619 8 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116620444 Nonpathogen - von Willebrand factor, type A Acid_1322 2 COG2425 COG2425, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 116619920 Nonpathogen - putative transmembrane anti-sigma factor Acid_0792 4 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 116619388 Common - protocatechuate 3,4-dioxygenase, beta subunit Acid_0247 54 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 116621490 Common - Redoxin domain protein Acid_2372 41 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116623866 Common - periplasmic protein-like protein Acid_4778 9 COG3895 COG3895, Predicted periplasmic protein General function prediction only 116624484 Common - YidE/YbjL duplication Acid_5406 52 COG2985 COG2985, Predicted permease General function prediction only 116625085 Nonpathogen - hypothetical protein Acid_6019 1 None None None 116620532 Common - type II and III secretion system protein Acid_1410 139 COG4964 CpaC, Flp pilus assembly protein, secretin CpaC Intracellular trafficking and secretion 116619949 Common - thiamine-monophosphate kinase Acid_0821 179 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 116621622 Common - argininosuccinate lyase Acid_2504 216 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 116623464 Common - phosphoglycerate mutase 1 family Acid_4374 165 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 116623578 Nonpathogen - hypothetical protein Acid_4488 2 None None None 116619573 Common - glucose-methanol-choline oxidoreductase Acid_0434 37 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 116621924 Common - RNA methyltransferase, TrmH family, group 3 Acid_2809 215 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 116626058 Common - glycosyl transferase, group 1 Acid_7016 214 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116625549 Nonpathogen - hypothetical protein Acid_6496 2 None None None 116622171 Common - hypothetical protein Acid_3063 7 None None None 116625968 Common - nickel-dependent hydrogenase, large subunit Acid_6926 106 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 116621451 Common - ATPase AAA-2 domain protein Acid_2333 216 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 116619449 Common - thioredoxin Acid_0308 232 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 116622764 Common - Phytanoyl-CoA dioxygenase Acid_3663 41 COG5285 COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin Secondary metabolites biosynthesis, transport, and catabolism 116624514 Common - Curli production assembly/transport component CsgG Acid_5438 18 COG1462 CsgG, Uncharacterized protein involved in formation of curli polymers Cell envelope biogenesis, outer membrane 116626458 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Acid_7420 157 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 116625919 Common - hypothetical protein Acid_6876 18 None None None 116620815 Common - helix-hairpin-helix motif Acid_1696 232 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 116621716 Common - malonyl CoA-acyl carrier protein transacylase Acid_2598 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 116623206 Nonpathogen - hypothetical protein Acid_4113 1 None None None 116624102 Common - bidirectional hydrogenase complex protein HoxU Acid_5017 181 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 116620760 Common - FMN-dependent alpha-hydroxy acid dehydrogenase Acid_1641 114 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 116626271 Common - protein of unknown function DUF1680 Acid_7231 32 COG3533 COG3533, Uncharacterized protein conserved in bacteria Function unknown 116623403 Common - hypothetical protein Acid_4312 17 None None None 116626062 Common - serine/threonine protein kinase with WD40 repeats Acid_7020 158 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116625834 Common - integral membrane sensor signal transduction histidine kinase Acid_6787 221 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 116626648 Nonpathogen - hypothetical protein Acid_7614 1 None None None 116619970 Nonpathogen - protein of unknown function DUF1552 Acid_0842 6 None None None 116620662 Common - ABC transporter related Acid_1542 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116621509 Nonpathogen - hypothetical protein Acid_2391 1 None None None 116622348 Common - protein of unknown function DUF214 Acid_3242 142 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116626734 Common - protein of unknown function DUF214 Acid_7706 40 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622438 Nonpathogen - hypothetical protein Acid_3336 1 None None None 116623338 Nonpathogen - hypothetical protein Acid_4247 1 None None None 116619782 Common - transcriptional regulator, PadR-like family Acid_0652 6 COG1695 COG1695, Predicted transcriptional regulators Transcription 116622511 Common - acriflavin resistance protein Acid_3409 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116623270 Common - hypothetical protein Acid_4177 11 None None None 116622216 Nonpathogen - hypothetical protein Acid_3108 2 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 116620858 Common - short-chain dehydrogenase/reductase SDR Acid_1739 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116626553 Nonpathogen - hypothetical protein Acid_7516 1 None None None 116621863 Common - peptide deformylase Acid_2746 214 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 116626879 Common - membrane protein-like protein Acid_7855 50 COG2323 COG2323, Predicted membrane protein Function unknown 116619425 Nonpathogen - hypothetical protein Acid_0284 1 None None None 116621702 Nonpathogen - hypothetical protein Acid_2584 1 None None None 116626397 Common - AMP-dependent synthetase and ligase Acid_7357 220 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116626547 Common - hypothetical protein Acid_7510 23 None None None 116619708 Common - NUDIX hydrolase Acid_0573 157 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 116619665 Common - anti-sigma-factor antagonist Acid_0528 30 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 116624853 Common - protein of unknown function DUF892 Acid_5777 38 COG3685 COG3685, Uncharacterized protein conserved in bacteria Function unknown 116626021 Common dapD 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase Acid_6979 140 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 116623626 Common - Ketosteroid isomerase-like protein Acid_4536 7 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 116623488 Common - dienelactone hydrolase Acid_4398 18 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 116623888 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Acid_4800 109 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 116622262 Common - Integrase, catalytic region Acid_3156 152 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116623335 Common - glycosyl transferase, group 1 Acid_4244 194 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116622522 Common - von Willebrand factor, type A Acid_3420 41 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 116624394 Common - acriflavin resistance protein Acid_5315 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116619459 Nonpathogen - hypothetical protein Acid_0318 1 None None None 116624678 Common - magnesium and cobalt transport protein CorA Acid_5602 167 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 116626562 Common - protein of unknown function DUF1080 Acid_7525 10 None None None 116626285 Nonpathogen - hypothetical protein Acid_7245 1 COG5373 COG5373, Predicted membrane protein Function unknown 116619547 Common - hypothetical protein Acid_0408 6 None None None 116621257 Common - methyl-accepting chemotaxis sensory transducer Acid_2138 80 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 116626003 Common - oxaloacetate decarboxylase Acid_6961 142 COG5016 COG5016, Pyruvate/oxaloacetate carboxyltransferase Energy production and conversion 116621402 Common - Tetratricopeptide domain protein Acid_2284 27 None None None 116626836 Nonpathogen - hypothetical protein Acid_7809 4 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116623521 Common - serine/threonine protein kinase Acid_4431 193 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116619510 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_0369 173 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116621817 Common - hypothetical protein Acid_2699 4 None None None 116625443 Nonpathogen - hypothetical protein Acid_6388 8 None None None 116619661 Common - DSBA oxidoreductase Acid_0524 86 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 116625192 Common - hypothetical protein Acid_6137 20 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116626857 Common - integral membrane protein Acid_7832 6 None None None 116621170 Nonpathogen - hypothetical protein Acid_2051 4 None None None 116621839 Common - peptidase S41 Acid_2721 11 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 116621865 Common - arginine biosynthesis bifunctional protein ArgJ Acid_2748 167 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 116622376 Common - methylamine utilization protein MauG, putative Acid_3270 42 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 116625681 Common - amidohydrolase Acid_6630 19 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 116620987 Common - glycosyl hydrolase, BNR repeat-containing protein Acid_1868 53 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116624756 Common - hypothetical protein Acid_5680 5 COG4634 COG4634, Uncharacterized protein conserved in bacteria Function unknown 116626498 Common fliP flagellar biosynthesis protein FliP Acid_7461 128 COG1338 FliP, Flagellar biosynthesis pathway, component FliP Cell motility and secretion / Intracellular trafficking and secretion 116625929 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_6886 115 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116626278 Common - cold-shock DNA-binding domain protein Acid_7238 182 COG1278 CspC, Cold shock proteins Transcription 116626747 Common - Redoxin domain protein Acid_7719 211 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116624630 Common - major intrinsic protein Acid_5554 131 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 116621397 Nonpathogen - hypothetical protein Acid_2279 1 None None None 116621165 Common - GAF sensor hybrid histidine kinase Acid_2046 225 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116621884 Nonpathogen - hypothetical protein Acid_2767 1 None None None 116623946 Common - GCN5-related N-acetyltransferase Acid_4858 6 COG0456 RimI, Acetyltransferases General function prediction only 116620255 Common - signal transduction histidine kinase, LytS Acid_1132 102 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 116624876 Common - hypothetical protein Acid_5800 31 COG3247 HdeD, Uncharacterized conserved protein Function unknown 116626794 Common - protein of unknown function DUF72 Acid_7767 41 COG1801 COG1801, Uncharacterized conserved protein Function unknown 116621193 Common - lipolytic enzyme, G-D-S-L family Acid_2074 17 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116625197 Common - protein of unknown function DUF1080 Acid_6142 9 None None None 116622108 Common - Alcohol dehydrogenase GroES domain protein Acid_2995 205 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 116623685 Common - UDP-glucose 6-dehydrogenase Acid_4597 206 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 116619322 Common - acetolactate synthase, small subunit Acid_0179 193 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 116619209 Nonpathogen - hypothetical protein Acid_0064 2 None None None 116622326 Common - transcriptional regulator, PadR-like family Acid_3220 30 COG1695 COG1695, Predicted transcriptional regulators Transcription 116621485 Common - ABC transporter related Acid_2367 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 116625014 Common - phosphoribosylformylglycinamidine synthase II Acid_5944 233 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 116621305 Common - NHL repeat containing protein Acid_2186 42 None None None 116619293 Common - phage Tail Collar domain protein Acid_0149 37 COG4675 MdpB, Microcystin-dependent protein Function unknown 116624551 Common - transcriptional regulator, MerR family Acid_5475 37 COG0789 SoxR, Predicted transcriptional regulators Transcription 116626390 Common - Isocitrate dehydrogenase (NAD(+)) Acid_7350 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 116621959 Common - DNA-formamidopyrimidine glycosylase Acid_2844 180 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 116626145 Common - Integrase, catalytic region Acid_7104 78 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 116619911 Nonpathogen - hypothetical protein Acid_0783 1 None None None 116625413 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Acid_6358 177 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 116624159 Nonpathogen - Lytic transglycosylase, catalytic Acid_5075 1 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 116619979 Common - peptidase S41 Acid_0851 156 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 116622198 Common - Formyl-CoA transferase Acid_3090 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 116619440 Common - Serine/threonine protein kinase-like protein Acid_0299 58 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116621266 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_2147 149 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116625906 Common - Integrase, catalytic region Acid_6862 153 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116626173 Nonpathogen - hypothetical protein Acid_7133 2 COG5305 COG5305, Predicted membrane protein Function unknown 116623392 Nonpathogen - hypothetical protein Acid_4301 1 None None None 116626780 Common - SAF domain Acid_7753 65 COG3745 CpaB, Flp pilus assembly protein CpaB Intracellular trafficking and secretion 116624093 Common - hypothetical protein Acid_5008 46 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116625795 Common - asparaginase Acid_6745 72 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 116626029 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_6987 58 COG1146 COG1146, Ferredoxin Energy production and conversion 116624257 Common - hypothetical protein Acid_5175 6 None None None 116620123 Common - Methyltransferase type 12 Acid_0996 82 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116626912 Common - Phosphoribosylanthranilate isomerase Acid_7889 185 COG0135 TrpF, Phosphoribosylanthranilate isomerase Amino acid transport and metabolism 116620990 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Acid_1871 114 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 116619192 Nonpathogen - hypothetical protein Acid_0047 2 None None None 116621041 Common - two component, sigma54 specific, transcriptional regulator, Fis family Acid_1922 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116625956 Common - Catalase Acid_6914 46 COG3546 COG3546, Mn-containing catalase Inorganic ion transport and metabolism 116622542 Nonpathogen - hypothetical protein Acid_3440 1 None None None 116622227 Nonpathogen - hypothetical protein Acid_3120 7 None None None 116623532 Common - protein of unknown function DUF214 Acid_4442 41 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116626420 Common - glucose-methanol-choline oxidoreductase Acid_7382 76 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 116621174 Nonpathogen - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_2055 1 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116622093 Common - secreted protein Acid_2980 9 None None None 116626372 Nonpathogen - hypothetical protein Acid_7332 2 None None None 116619864 Common - response regulator receiver protein Acid_0736 55 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116626256 Common - hypothetical protein Acid_7216 15 None None None 116620239 Common - NAD(+) kinase Acid_1116 229 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 116620383 Common - squalene-hopene cyclase Acid_1260 44 COG1657 SqhC, Squalene cyclase Lipid metabolism 116621667 Common - Rieske (2Fe-2S) domain protein Acid_2549 96 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 116624139 Common - nucleoside:H+ symporter Acid_5055 48 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 116622607 Common - Cytochrome b/b6, N-terminal domain Acid_3505 149 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 116626266 Common - protein of unknown function DUF1080 Acid_7226 9 None None None 116622509 Common - RND efflux system, outer membrane lipoprotein, NodT family Acid_3407 116 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116619713 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Acid_0578 27 COG4934 COG4934, Predicted protease Posttranslational modification, protein turnover, chaperones 116623368 Nonpathogen - conserved hypothetical protein, signal peptide and transmembrane prediction Acid_4277 2 None None None 116625479 Common - molybdenum cofactor biosynthesis protein A Acid_6425 197 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 116621785 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Acid_2667 114 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116621735 Nonpathogen - hypothetical protein Acid_2617 1 None None None 116619773 Common - methyltransferase FkbM family Acid_0643 67 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 116625253 Common - protein of unknown function DUF1028 Acid_6198 39 COG3342 COG3342, Uncharacterized conserved protein Function unknown 116619519 Common - glycosyl transferase, family 9 Acid_0378 61 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 116623950 Nonpathogen - conserved hypothetical cytosolic protein Acid_4862 4 None None None 116625385 Common - hypothetical protein Acid_6330 14 COG1102 Cmk, Cytidylate kinase Nucleotide transport and metabolism 116625537 Common - protein of unknown function DUF214 Acid_6484 157 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116624172 Common - aldehyde dehydrogenase Acid_5088 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 116620437 Common - transcriptional regulator, Crp/Fnr family Acid_1315 117 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 116624852 Nonpathogen - hypothetical protein Acid_5776 1 None None None 116622906 Common - protein of unknown function DUF214 Acid_3807 148 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116626294 Common - GTP-binding protein TypA Acid_7254 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 116622820 Common - CsbD family protein Acid_3720 55 COG3237 COG3237, Uncharacterized protein conserved in bacteria Function unknown 116626087 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Acid_7045 31 None None None 116623160 Common - transcriptional regulator, LysR family Acid_4066 192 COG0583 LysR, Transcriptional regulator Transcription 116623618 Nonpathogen - hypothetical protein Acid_4528 1 None None None 116620432 Common - 4-hydroxybenzoate polyprenyltransferase, putative Acid_1310 113 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 116621418 Common - alpha-2-macroglobulin domain protein Acid_2300 84 COG2373 COG2373, Large extracellular alpha-helical protein General function prediction only 116623279 Common - hypothetical protein Acid_4186 24 None None None 116621649 Nonpathogen - hypothetical protein Acid_2531 1 None None None 116619777 Common - hypothetical protein Acid_0647 70 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 116625523 Common - surface antigen (D15) Acid_6470 159 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 116626099 Nonpathogen - ADP-heptose:LPS heptosyltransferase-like protein Acid_7057 1 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 116623255 Nonpathogen - peptidase A24A, prepilin type IV Acid_4162 1 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 116622617 Common - peptidase M28 Acid_3516 40 COG2234 Iap, Predicted aminopeptidases General function prediction only 116621548 Common - putative RNA polymerase, sigma-24 subunit, ECF subfamily Acid_2430 52 COG4941 COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain Transcription 116624447 Common - CheA signal transduction histidine kinase Acid_5369 152 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 116623951 Common - DegT/DnrJ/EryC1/StrS aminotransferase Acid_4863 125 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 116623349 Nonpathogen - hypothetical protein Acid_4258 1 None None None 116623316 Common - TonB-dependent receptor, plug Acid_4224 18 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116625912 Common - TonB-dependent receptor Acid_6869 24 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116620270 Common - hypothetical protein Acid_1147 15 None None None 116626135 Common - ribosomal protein S6 Acid_7093 204 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 116625832 Nonpathogen - hypothetical protein Acid_6785 1 None None None 116625052 Common - protein of unknown function DUF214 Acid_5982 167 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622409 Common - Alcohol dehydrogenase, zinc-binding domain protein Acid_3304 197 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 116619877 Common - UBA/THIF-type NAD/FAD binding protein Acid_0749 209 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 116624134 Common - hypothetical protein Acid_5050 6 None None None 116622425 Common - protein of unknown function DUF542, ScdA domain protein Acid_3322 45 COG2846 COG2846, Regulator of cell morphogenesis and NO signaling Cell division and chromosome partitioning 116621996 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_2881 160 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116624859 Nonpathogen - Radical SAM domain protein Acid_5783 19 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116620399 Common - queuine tRNA-ribosyltransferase Acid_1276 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 116623466 Common - luciferase family protein Acid_4376 104 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 116625226 Nonpathogen - hypothetical protein Acid_6171 1 None None None 116623524 Common - acyltransferase 3 Acid_4434 14 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 116620550 Common - WD40 domain protein beta Propeller Acid_1428 152 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116625853 Common - Integrase, catalytic region Acid_6807 86 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 116620997 Common - hypothetical protein Acid_1878 5 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 116621012 Nonpathogen - hypothetical protein Acid_1893 1 None None None 116622400 Nonpathogen - hypothetical protein Acid_3294 1 None None None 116622011 Nonpathogen - hypothetical protein Acid_2896 1 None None None 116619178 Nonpathogen - hypothetical protein Acid_0033 1 None None None 116625432 Common - von Willebrand factor, type A Acid_6377 24 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 116626414 Nonpathogen - hypothetical protein Acid_7376 2 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116622221 Common - histidine kinase Acid_3114 83 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116623927 Common - transcriptional regulator, PadR-like family Acid_4839 17 COG1695 COG1695, Predicted transcriptional regulators Transcription 116620390 Common - putative PAS/PAC sensor protein Acid_1267 162 COG2202 AtoS, FOG: PAS/PAC domain Signal transduction mechanisms 116619157 Common - DNA polymerase III, alpha subunit Acid_0012 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 116624563 Common - O-acetylhomoserine/O-acetylserine sulfhydrylase Acid_5487 207 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 116621155 Nonpathogen - hypothetical protein Acid_2036 3 None None None 116622728 Common - TonB family protein Acid_3627 17 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 116623957 Common - Lytic transglycosylase, catalytic Acid_4869 134 COG4623 COG4623, Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein Cell envelope biogenesis, outer membrane 116623558 Nonpathogen - hypothetical protein Acid_4468 1 None None None 116619319 Common - 6-phosphogluconate dehydrogenase, NAD-binding Acid_0176 157 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 116621077 Common - electron transport protein SCO1/SenC Acid_1958 51 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 116625987 Common - GCN5-related N-acetyltransferase Acid_6945 44 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 116623029 Nonpathogen - hypothetical protein Acid_3933 1 None None None 116622516 Common - multi-sensor signal transduction histidine kinase Acid_3414 222 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 116621232 Nonpathogen - cytochrome c, class I Acid_2113 5 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 116623112 Common - hypothetical protein Acid_4017 6 None None None 116626596 Common - biotin--acetyl-CoA-carboxylase ligase Acid_7559 215 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 116624001 Nonpathogen - hypothetical protein Acid_4913 2 None None None 116623657 Nonpathogen - hypothetical protein Acid_4569 1 None None None 116626587 Common - transcriptional regulator, PadR-like family Acid_7550 50 COG1695 COG1695, Predicted transcriptional regulators Transcription 116624542 Nonpathogen - protein of unknown function DUF214 Acid_5466 7 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116625428 Common - ABC transporter related Acid_6373 150 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 116619149 Common - tetratricopeptide repeat protein Acid_0004 26 None None None 116621532 Nonpathogen - hypothetical protein Acid_2414 2 None None None 116622501 Common - von Willebrand factor, type A Acid_3399 33 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 116624264 Common - protein of unknown function DUF503 Acid_5182 37 COG1550 COG1550, Uncharacterized protein conserved in bacteria Function unknown 116620326 Common - Substrate-binding region of ABC-type glycine betaine transport system Acid_1203 90 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 116623837 Common - oxidoreductase domain protein Acid_4749 165 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116619694 Nonpathogen - hypothetical protein Acid_0559 1 COG4641 COG4641, Uncharacterized protein conserved in bacteria Function unknown 116622600 Nonpathogen - hypothetical protein Acid_3498 1 None None None 116624956 Common - hypothetical protein Acid_5885 3 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116625402 Common - transcriptional repressor, CopY family Acid_6347 42 COG3682 COG3682, Predicted transcriptional regulator Transcription 116626176 Common - 1-deoxy-D-xylulose 5-phosphate reductoisomerase Acid_7136 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 116622816 Common - aminotransferase, class V Acid_3716 239 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 116624517 Nonpathogen - hypothetical protein Acid_5441 1 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 116625649 Common - cyanophycinase and related exopeptidase-like protein Acid_6598 29 COG4242 CphB, Cyanophycinase and related exopeptidases Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism 116626363 Common - Ig domain protein, group 2 domain protein Acid_7323 23 COG5479 COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis Cell envelope biogenesis, outer membrane 116619894 Common - ATP synthase F0, A subunit Acid_0766 199 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 116624039 Common - FMN-binding negative transcriptional regulator Acid_4953 59 COG2808 PaiB, Transcriptional regulator Transcription 116624395 Nonpathogen - hypothetical protein Acid_5316 1 None None None 116625775 Nonpathogen - hypothetical protein Acid_6725 2 None None None 116625241 Common - protein of unknown function DUF1549 Acid_6186 7 None None None 116624657 Common - signal transduction histidine kinase, LytS Acid_5581 102 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 116626523 Common - putative signal-transduction protein with CBS domains Acid_7486 139 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 116626961 Nonpathogen - hypothetical protein Acid_7938 1 None None None 116625211 Nonpathogen - hypothetical protein Acid_6156 1 None None None 116620367 Nonpathogen - protein of unknown function DUF1552 Acid_1244 6 None None None 116622925 Common - Methyltransferase type 11 Acid_3827 35 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116621796 Common - ROK family protein Acid_2678 171 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 116626454 Common - protein of unknown function DUF195 Acid_7416 126 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 116626941 Common - transcriptional regulator, XRE family Acid_7918 38 COG2944 COG2944, Predicted transcriptional regulator Transcription 116623098 Common - methylated-DNA--protein-cysteine methyltransferase Acid_4002 217 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 116626472 Common - ABC transporter related Acid_7435 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116623258 Common - NAD-dependent epimerase/dehydratase Acid_4165 55 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116624988 Nonpathogen - hypothetical protein Acid_5918 1 COG4371 COG4371, Predicted membrane protein Function unknown 116619602 Common - ATP synthase F1, alpha subunit Acid_0463 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 116620743 Common - transposase IS3/IS911 family protein Acid_1624 32 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 116623253 Common - type II secretion system protein E Acid_4160 224 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 116623045 Common - surface antigen (D15) Acid_3949 145 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 116624174 Common - DNA-directed RNA polymerase subunit alpha Acid_5090 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 116626411 Common - protein of unknown function DUF1080 Acid_7373 9 None None None 116623083 Nonpathogen - hypothetical protein Acid_3987 1 None None None 116620838 Common - Semialdehyde dehydrogenase, dimerisation region Acid_1719 56 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 116621378 Common - oxidoreductase domain protein Acid_2259 112 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116625647 Common - protein of unknown function DUF214 Acid_6596 49 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620167 Common - helicase c2 Acid_1040 153 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 116624220 Nonpathogen - hypothetical protein Acid_5136 1 None None None 116626668 Common - serine/threonine protein kinase Acid_7637 159 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116626572 Common - Alcohol dehydrogenase GroES domain protein Acid_7535 216 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 116625222 Nonpathogen - transcriptional regulator, LuxR family Acid_6167 4 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116624276 Common - OsmC family protein Acid_5194 30 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 116623712 Common - asparagine synthase (glutamine-hydrolyzing) Acid_4624 149 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 116620766 Common - polysaccharide export protein Acid_1647 116 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 116623297 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_4204 164 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 116620064 Nonpathogen - hypothetical protein Acid_0936 5 None None None 116621782 Common - lipolytic enzyme, G-D-S-L family Acid_2664 23 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116626658 Common - plasmid related protein Acid_7627 19 None None None 116621673 Nonpathogen - hypothetical protein Acid_2555 1 None None None 116619885 Common - Mov34/MPN/PAD-1 family protein Acid_0757 38 COG1310 COG1310, Predicted metal-dependent protease of the PAD1/JAB1 superfamily General function prediction only 116619704 Common fkp bifunctional fucokinase/L-fucose-1-P-guanylyltransferase Acid_0569 32 COG2605 COG2605, Predicted kinase related to galactokinase and mevalonate kinase General function prediction only 116624556 Nonpathogen - hypothetical protein Acid_5480 2 None None None 116624913 Common - major facilitator superfamily MFS_1 Acid_5839 121 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116624611 Common - hypothetical protein Acid_5535 11 None None None 116621768 Common - efflux transporter, RND family, MFP subunit Acid_2650 162 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 116624681 Common - beta-lactamase Acid_5605 142 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116624033 Nonpathogen - hypothetical protein Acid_4945 2 None None None 116619180 Nonpathogen - hypothetical protein Acid_0035 2 COG4371 COG4371, Predicted membrane protein Function unknown 116623746 Common - glycosyl transferase, family 4 Acid_4658 226 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 116623366 Common - putative acetyl xylan esterase Acid_4275 7 None None None 116624126 Common - phosphoribosylaminoimidazole carboxylase, catalytic subunit Acid_5042 232 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 116624238 Common - sigma54 specific transcriptional regulator, Fis family Acid_5155 176 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 116624788 Nonpathogen - hypothetical protein Acid_5712 2 None None None 116623242 Common - protein of unknown function DUF214 Acid_4149 19 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620898 Common - FMN-dependent alpha-hydroxy acid dehydrogenase Acid_1779 122 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 116621631 Nonpathogen - hypothetical protein Acid_2513 1 None None None 116623785 Common - protein of unknown function DUF72 Acid_4697 29 COG1801 COG1801, Uncharacterized conserved protein Function unknown 116621104 Common - glycosyl transferase, family 28 Acid_1985 37 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 116623598 Common - hypothetical protein Acid_4508 25 None None None 116621943 Common - Sec-independent protein translocase, TatC subunit Acid_2828 199 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 116622493 Common - hypothetical protein Acid_3391 9 None None None 116619583 Common - hypothetical protein Acid_0444 8 None None None 116622453 Common - Geranyltranstransferase Acid_3351 242 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 116626531 Nonpathogen - hypothetical protein Acid_7494 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116626932 Common - drug resistance transporter, EmrB/QacA subfamily Acid_7909 192 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116625936 Common - hypothetical protein Acid_6894 7 None None None 116626140 Common - adenine phosphoribosyltransferase Acid_7098 166 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 116620653 Common - peptidase M14, carboxypeptidase A Acid_1533 14 None None None 116624715 Common - beta-lactamase Acid_5639 106 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116623380 Common - oxidoreductase domain protein Acid_4289 78 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116626060 Common - sugar-phosphate isomerases, RpiB/LacA/LacB family Acid_7018 128 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 116623848 Common - DNA mismatch repair protein MutS Acid_4760 199 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 116625151 Common - hypothetical protein Acid_6091 4 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 116620811 Nonpathogen - hypothetical protein Acid_1692 3 None None None 116626875 Common - Tetratricopeptide TPR_2 repeat protein Acid_7851 125 COG5616 COG5616, Predicted integral membrane protein Function unknown 116621182 Common - Pyrrolo-quinoline quinone Acid_2063 59 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116623895 Common - Rhomboid family protein Acid_4807 144 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 116622477 Common - alanine dehydrogenase/PNT domain protein Acid_3375 167 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 116621183 Common - cytochrome c, class I Acid_2064 38 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 116624736 Common - FolC bifunctional protein Acid_5660 217 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 116619455 Common - protein of unknown function DUF205 Acid_0314 170 COG0344 COG0344, Predicted membrane protein Function unknown 116626196 Common - FkbH like protein Acid_7156 31 COG3882 FkbH, Predicted enzyme involved in methoxymalonyl-ACP biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 116624609 Nonpathogen - hypothetical protein Acid_5533 1 None None None 116624076 Nonpathogen - hypothetical protein Acid_4990 7 None None None 116622471 Nonpathogen - hypothetical protein Acid_3369 2 None None None 116621211 Common - Carboxylesterase, type B Acid_2092 65 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 116623511 Common - Phosphoglycerate kinase Acid_4421 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 116623775 Common - transcriptional regulator, PadR-like family Acid_4687 61 COG1695 COG1695, Predicted transcriptional regulators Transcription 116620334 Nonpathogen - hypothetical protein Acid_1211 1 COG1405 SUA7, Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB Transcription 116623172 Common - Tetratricopeptide TPR_2 repeat protein Acid_4079 119 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116626280 Common - ATPase AAA-2 domain protein Acid_7240 216 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 116622944 Nonpathogen - hypothetical protein Acid_3846 1 None None None 116623659 Common - Flotillin domain protein Acid_4571 149 COG2268 COG2268, Uncharacterized protein conserved in bacteria Function unknown 116625380 Common - NusG antitermination factor Acid_6325 215 COG0250 NusG, Transcription antiterminator Transcription 116622470 Common - hypothetical protein Acid_3368 24 None None None 116624197 Common - ribosomal protein L22 Acid_5113 216 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 116624344 Common - hypothetical protein Acid_5262 6 None None None 116620288 Common - electron transfer flavoprotein, alpha subunit Acid_1165 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 116619947 Common - Integrase, catalytic region Acid_0819 77 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 116623065 Nonpathogen - hypothetical protein Acid_3969 1 None None None 116620930 Nonpathogen - hypothetical protein Acid_1811 1 None None None 116625391 Nonpathogen - hypothetical protein Acid_6336 2 None None None 116623939 Nonpathogen - protein of unknown function DUF202 Acid_4851 4 COG2149 COG2149, Predicted membrane protein Function unknown 116623841 Common - hypothetical protein Acid_4753 9 None None None 116619592 Common - ABC transporter related Acid_0453 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 116624841 Nonpathogen - Dinitrogenase iron-molybdenum cofactor biosynthesis Acid_5765 8 COG1433 COG1433, Uncharacterized conserved protein Function unknown 116625836 Nonpathogen - putative phophoslipid binding protein Acid_6789 2 None None None 116624900 Common - ankyrin-related protein Acid_5825 84 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 116619826 Common - plasmid pRiA4b ORF-3 family protein Acid_0696 44 None None None 116626939 Common - serine/threonine protein kinase Acid_7916 168 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116624195 Common rplP 50S ribosomal protein L16 Acid_5111 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 116622615 Common - heavy metal translocating P-type ATPase Acid_3513 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 116619737 Common - ABC transporter related Acid_0602 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116626884 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_7860 166 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116626220 Common - protein of unknown function DUF255 Acid_7180 105 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 116620061 Common - glycoside hydrolase, clan GH-D Acid_0933 45 COG3345 GalA, Alpha-galactosidase Carbohydrate transport and metabolism 116622081 Common - response regulator receiver protein Acid_2968 145 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116619690 Common - ABC-2 type transporter Acid_0555 127 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116621826 Common - short chain dehydrogenase Acid_2708 238 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 116619343 Nonpathogen - hypothetical protein Acid_0200 2 COG3661 AguA, Alpha-glucuronidase Carbohydrate transport and metabolism 116620570 Common - Thiosulfate reductase cytochrome B subunit (membrane anchoring protein)-like protein Acid_1448 36 COG4117 COG4117, Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) Energy production and conversion 116625003 Nonpathogen - hypothetical protein Acid_5933 1 None None None 116626208 Common - Tetratricopeptide TPR_4 Acid_7168 20 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116620554 Common - methionine biosynthesis protein MetW Acid_1432 60 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116620621 Nonpathogen - Sporulation domain protein Acid_1500 1 COG5373 COG5373, Predicted membrane protein Function unknown 116623864 Common - protein of unknown function DUF214 Acid_4776 96 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620525 Common - molybdenum cofactor synthesis domain Acid_1403 190 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 116626630 Nonpathogen - TadE family protein Acid_7595 1 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 116624600 Nonpathogen - hypothetical protein Acid_5524 1 None None None 116621396 Common - ATPase AAA-2 domain protein Acid_2278 226 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 116626131 Common - transcriptional regulator, CadC Acid_7089 71 COG3710 CadC, DNA-binding winged-HTH domains Transcription 116626067 Nonpathogen - hypothetical protein Acid_7025 1 None None None 116622733 Common - Propeptide, PepSY amd peptidase M4 Acid_3632 70 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 116624648 Common - N-acetylglucosamine-6-phosphate deacetylase Acid_5572 118 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 116623733 Common - glycosyl transferase, family 2 Acid_4645 189 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116626262 Common - transcriptional regulator, LysR family Acid_7222 192 COG0583 LysR, Transcriptional regulator Transcription 116626968 Common - Cna B domain protein Acid_7945 24 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116621495 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Acid_2377 88 COG0388 COG0388, Predicted amidohydrolase General function prediction only 116626721 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Acid_7693 110 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 116621096 Common - short-chain dehydrogenase/reductase SDR Acid_1977 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 116620993 Nonpathogen - hypothetical protein Acid_1874 1 None None None 116626298 Common - ROK family protein Acid_7258 120 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 116621244 Common - glycosyl transferase, family 2 Acid_2125 146 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116625865 Nonpathogen - hypothetical protein Acid_6819 1 None None None 116624778 Common - malate synthase Acid_5702 65 COG2225 AceB, Malate synthase Energy production and conversion 116622469 Nonpathogen - hypothetical protein Acid_3367 1 None None None 116625766 Common - ABC transporter related Acid_6716 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 116622405 Nonpathogen - hypothetical protein Acid_3300 2 None None None 116619220 Common - potassium-transporting ATPase, C subunit Acid_0075 95 COG2156 KdpC, K+-transporting ATPase, c chain Inorganic ion transport and metabolism 116622295 Nonpathogen - hypothetical protein Acid_3189 2 None None None 116619468 Common - flagellin domain protein Acid_0327 124 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 116619808 Nonpathogen - hypothetical protein Acid_0678 1 None None None 116620247 Common - hypothetical protein Acid_1124 6 None None None 116621797 Common - glycoside hydrolase, family 3 domain protein Acid_2679 130 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 116619636 Common - cytochrome c oxidase, subunit II Acid_0497 157 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 116619821 Common - translation-associated GTPase Acid_0691 216 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 116619165 Common - Tetratricopeptide domain protein Acid_0020 4 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116619262 Common - proton-translocating NADH-quinone oxidoreductase, chain L Acid_0118 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 116620579 Common - Aldose 1-epimerase Acid_1458 92 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 116621773 Common - Alpha-L-fucosidase Acid_2655 33 COG3669 COG3669, Alpha-L-fucosidase Carbohydrate transport and metabolism 116621948 Nonpathogen - hypothetical protein Acid_2833 1 None None None 116622856 Common - Ankyrin Acid_3757 9 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 116621359 Common - short-chain dehydrogenase/reductase SDR Acid_2240 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116622596 Common - TPR repeat-containing protein Acid_3494 143 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116623470 Common - ABC-2 type transporter Acid_4380 127 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 116619211 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Acid_0066 209 COG0313 COG0313, Predicted methyltransferases General function prediction only 116623713 Common - Integrase, catalytic region Acid_4625 77 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 116625108 Common - putative acyl carrier protein Acid_6044 15 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116620640 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Acid_1519 115 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 116620871 Nonpathogen - hypothetical protein Acid_1752 2 None None None 116621937 Common - NIPSNAP family containing protein Acid_2822 11 None None None 116624402 Common - major facilitator superfamily MFS_1 Acid_5324 175 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116623669 Nonpathogen - hypothetical protein Acid_4581 3 None None None 116622253 Nonpathogen - hypothetical protein Acid_3146 1 None None None 116624941 Common - Ig family protein Acid_5868 49 COG3889 COG3889, Predicted solute binding protein General function prediction only 116626635 Common - peptidase M23B Acid_7600 14 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 116623526 Common - Clp N terminal domain protein Acid_4436 95 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 116621288 Nonpathogen - hypothetical protein Acid_2169 1 None None None 116626212 Common - serine/threonine protein kinase with TPR repeats Acid_7172 141 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116625097 Nonpathogen - hypothetical protein Acid_6033 1 None None None 116621714 Common - hypothetical protein Acid_2596 48 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116626071 Common - ribonuclease BN Acid_7029 61 COG1295 Rbn, Predicted membrane protein Function unknown 116626517 Common - lipolytic enzyme, G-D-S-L family Acid_7480 16 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116621438 Common - proton-translocating NADH-quinone oxidoreductase, chain M Acid_2320 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 116625445 Nonpathogen - hypothetical protein Acid_6390 5 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 116625756 Nonpathogen - hypothetical protein Acid_6706 1 None None None 116624007 Common - protein of unknown function DUF1080 Acid_4919 7 None None None 116625200 Common - oxidoreductase domain protein Acid_6145 48 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116620075 Common - hypothetical protein Acid_0947 27 COG4995 COG4995, Uncharacterized protein conserved in bacteria Function unknown 116626575 Nonpathogen - hypothetical protein Acid_7538 9 None None None 116624283 Common - ApbE family lipoprotein Acid_5201 138 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 116621669 Nonpathogen - hypothetical protein Acid_2551 1 None None None 116619706 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_0571 51 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 116623539 Nonpathogen - hypothetical protein Acid_4449 1 None None None 116624168 Common - monofunctional biosynthetic peptidoglycan transglycosylase Acid_5084 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 116623900 Common - condensation domain protein Acid_4812 14 None None None 116619756 Common - UDP-glucose 6-dehydrogenase Acid_0622 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 116621468 Common - phage SPO1 DNA polymerase-related protein Acid_2350 153 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 116623652 Common - hypothetical protein Acid_4564 7 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 116624571 Common - amidohydrolase Acid_5495 92 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116624741 Common - hypoxanthine phosphoribosyltransferase Acid_5665 150 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 116626229 Common - nitrogen regulatory protein P-II Acid_7189 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 116626787 Common - ribosomal protein S15 Acid_7760 214 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 116622191 Common - hypothetical protein Acid_3083 7 COG3595 COG3595, Uncharacterized conserved protein Function unknown 116624964 Common - protein of unknown function UPF0150 Acid_5893 23 COG1598 COG1598, Uncharacterized conserved protein Function unknown 116624325 Nonpathogen - hypothetical protein Acid_5243 1 None None None 116623414 Common - peptidase M56, BlaR1 Acid_4323 19 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 116622468 Common - transcriptional regulator, ArsR family Acid_3366 60 COG0640 ArsR, Predicted transcriptional regulators Transcription 116621294 Common - oxidoreductase domain protein Acid_2175 74 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116626336 Common - aldo/keto reductase Acid_7296 139 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116621191 Common - lipolytic enzyme, G-D-S-L family Acid_2072 30 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116620793 Common - aminotransferase class-III Acid_1674 238 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 116623420 Common - hypothetical protein Acid_4329 11 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 116624986 Nonpathogen - hypothetical protein Acid_5916 1 None None None 116625261 Nonpathogen - TonB family protein Acid_6206 6 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 116625101 Nonpathogen - hypothetical protein Acid_6037 1 None None None 116620096 Common - aldehyde dehydrogenase Acid_0968 221 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 116622751 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Acid_3650 121 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 116625022 Common - TonB-dependent receptor Acid_5952 16 None None None 116625690 Common - alpha/beta hydrolase fold Acid_6639 156 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 116622497 Nonpathogen - hypothetical protein Acid_3395 1 None None None 116624229 Nonpathogen - hypothetical protein Acid_5146 8 COG4932 COG4932, Predicted outer membrane protein Cell envelope biogenesis, outer membrane 116626418 Common - serine/threonine protein kinase with TPR repeats Acid_7380 181 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116623378 Nonpathogen - serine/arginine repetitive matrix 1 Acid_4287 1 None None None 116622838 Common - hypothetical protein Acid_3738 19 None None None 116620385 Nonpathogen - purine and other phosphorylases, family 1 Acid_1262 1 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 116621069 Common - peptidase M20 Acid_1950 184 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116621440 Nonpathogen - hypothetical protein Acid_2322 1 None None None 116622546 Common - serine/threonine protein kinase with TPR repeats Acid_3444 149 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116626048 Common - Xylose isomerase domain protein TIM barrel Acid_7006 14 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116624212 Nonpathogen - hypothetical protein Acid_5128 2 None None None 116625584 Nonpathogen - hypothetical protein Acid_6533 11 None None None 116623949 Common - polysaccharide biosynthesis protein CapD Acid_4861 191 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116625670 Nonpathogen - O-antigen polymerase Acid_6619 1 None None None 116625557 Nonpathogen - hypothetical protein Acid_6504 9 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 116626302 Nonpathogen - hypothetical protein Acid_7262 5 None None None 116623493 Common - type I phosphodiesterase/nucleotide pyrophosphatase Acid_4403 17 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 116622431 Nonpathogen - hypothetical protein Acid_3329 3 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 116624182 Common - preprotein translocase, SecY subunit Acid_5098 238 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 116623216 Common - O-antigen polymerase Acid_4123 32 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 116626223 Common - TonB-dependent receptor Acid_7183 23 None None None 116622973 Common - NIPSNAP family containing protein Acid_3876 12 None None None 116625693 Common - protein of unknown function DUF6, transmembrane Acid_6642 51 COG2510 COG2510, Predicted membrane protein Function unknown 116624546 Common - glycosyl transferase, family 2 Acid_5470 41 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 116623249 Common - hypothetical protein Acid_4156 68 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 116621790 Nonpathogen - hypothetical protein Acid_2672 2 None None None 116621536 Nonpathogen - hypothetical protein Acid_2418 2 None None None 116624781 Nonpathogen - Tfp pilus assembly protein PilE-like protein Acid_5705 1 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 116619324 Common - uroporphyrin-III C-methyltransferase Acid_0181 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 116620772 Common - citrate synthase I Acid_1653 193 COG0372 GltA, Citrate synthase Energy production and conversion 116623670 Common - Glutamate carboxypeptidase II Acid_4582 28 COG2234 Iap, Predicted aminopeptidases General function prediction only 116623650 Common - acriflavin resistance protein Acid_4562 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116622905 Common - protein of unknown function DUF214 Acid_3806 167 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116619650 Nonpathogen - TonB family protein Acid_0511 4 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 116624586 Common - peptidase domain protein Acid_5510 14 None None None 116622958 Nonpathogen - hypothetical protein Acid_3860 1 None None None 116624884 Common - transaldolase Acid_5808 61 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 116622980 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Acid_3883 242 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 116620638 Common - peptidase M28 Acid_1517 37 COG2234 Iap, Predicted aminopeptidases General function prediction only 116621974 Common - Alcohol dehydrogenase GroES domain protein Acid_2859 209 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 116625748 Nonpathogen - nucleic acid binding, OB-fold, tRNA/helicase-type Acid_6698 2 None None None 116623563 Common - Radical SAM domain protein Acid_4473 117 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116619394 Common - Methionine synthase, vitamin-B12 independent Acid_0253 47 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 116622803 Nonpathogen - hypothetical protein Acid_3703 1 None None None 116626436 Common - alanine racemase Acid_7398 199 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 116624089 Common - hypothetical protein Acid_5004 14 None None None 116624753 Nonpathogen - hypothetical protein Acid_5677 4 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116622002 Common - response regulator receiver protein Acid_2887 18 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116625927 Nonpathogen - hypothetical protein Acid_6884 1 None None None 116619718 Common - peptidase S58, DmpA Acid_0583 51 COG3191 DmpA, L-aminopeptidase/D-esterase Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116620043 Common - glycoside hydrolase, family 29 (alpha-L-fucosidase) Acid_0915 30 COG3669 COG3669, Alpha-L-fucosidase Carbohydrate transport and metabolism 116625788 Nonpathogen - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_6738 7 None None None 116620360 Nonpathogen - hypothetical protein Acid_1237 3 COG3678 CpxP, P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism 116619789 Nonpathogen - Methyltransferase type 11 Acid_0659 11 COG0500 SmtA, SAM-dependent methyltransferases Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116620971 Common - two component, sigma54 specific, transcriptional regulator, Fis family Acid_1852 203 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116619681 Common - threonine synthase Acid_0546 134 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 116621348 Nonpathogen - hypothetical protein Acid_2229 5 None None None 116620328 Common - ABC transporter related Acid_1205 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 116620155 Common - putative regulatory protein, FmdB family Acid_1028 25 COG2331 COG2331, Uncharacterized protein conserved in bacteria Function unknown 116622443 Common - hypothetical protein Acid_3341 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116624148 Common - Undecaprenol kinase Acid_5064 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 116625468 Common - aminoglycoside phosphotransferase Acid_6414 6 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 116625632 Common - acetyl-CoA acyltransferase Acid_6581 144 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 116624843 Nonpathogen - hypothetical protein Acid_5767 2 None None None 116625499 Common - TPR repeat-containing protein Acid_6446 43 None None None 116620786 Common - Recombinase Acid_1667 83 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 116621205 Common - oxidoreductase domain protein Acid_2086 137 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116624413 Common - Tetratricopeptide TPR_2 repeat protein Acid_5335 20 None None None 116622531 Common - Peptidoglycan-binding LysM Acid_3429 51 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 116620837 Common - CDP-diacylglycerol--serine O-phosphatidyltransferase Acid_1718 145 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 116623264 Common - beta-lactamase domain protein Acid_4171 78 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 116624315 Common - inosine guanosine and xanthosine phosphorylase family Acid_5233 125 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 116621449 Common - plasmid maintenance system killer Acid_2331 58 COG3549 HigB, Plasmid maintenance system killer protein General function prediction only 116619360 Common - malto-oligosyltrehalose trehalohydrolase Acid_0218 156 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 116619512 Nonpathogen - hypothetical protein Acid_0371 1 None None None 116625550 Common - tetraacyldisaccharide 4'-kinase Acid_6497 130 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 116620022 Nonpathogen - hypothetical protein Acid_0894 2 COG3115 ZipA, Cell division protein Cell division and chromosome partitioning 116625396 Common - Cupin 2, conserved barrel domain protein Acid_6341 41 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 116619229 Nonpathogen - hypothetical protein Acid_0084 1 None None None 116625959 Common - Cupin 2, conserved barrel domain protein Acid_6917 20 COG4297 COG4297, Uncharacterized protein containing double-stranded beta helix domain Function unknown 116622649 Common - Radical SAM domain protein Acid_3548 80 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116623694 Common - hypothetical protein Acid_4606 29 COG4692 COG4692, Predicted neuraminidase (sialidase) Carbohydrate transport and metabolism 116623854 Common - major facilitator superfamily MFS_1 Acid_4766 166 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116624180 Common - methionine aminopeptidase, type I Acid_5096 249 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 116622350 Common - protein of unknown function DUF1080 Acid_3244 12 None None None 116622960 Common - aldo/keto reductase Acid_3862 176 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116623498 Common - protein tyrosine phosphatase Acid_4408 143 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 116626586 Common - protein of unknown function DUF894, DitE Acid_7549 115 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116623879 Nonpathogen - hypothetical protein Acid_4791 1 None None None 116625227 Nonpathogen - hypothetical protein Acid_6172 8 None None None 116625040 Nonpathogen - hypothetical protein Acid_5970 1 None None None 116620274 Nonpathogen - hypothetical protein Acid_1151 2 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 116623816 Common - ATPase with chaperone activity-like protein Acid_4728 27 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 116619369 Common - protein of unknown function DUF876 Acid_0227 49 COG3522 COG3522, Uncharacterized protein conserved in bacteria Function unknown 116621551 Common - protein of unknown function UPF0102 Acid_2433 125 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 116620955 Common - aminotransferase, class I and II Acid_1836 239 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 116620143 Nonpathogen - hypothetical protein Acid_1016 2 None None None 116620519 Nonpathogen - hypothetical protein Acid_1397 5 None None None 116621375 Common - aldo/keto reductase Acid_2256 184 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116625071 Common - Kelch repeat-containing protein Acid_6001 22 None None None 116626342 Nonpathogen - hypothetical protein Acid_7302 1 None None None 116625512 Nonpathogen - hypothetical protein Acid_6459 1 None None None 116620416 Common - Peptidylprolyl isomerase Acid_1293 198 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 116622758 Common - Polyphosphate kinase Acid_3657 161 COG0855 Ppk, Polyphosphate kinase Inorganic ion transport and metabolism 116620236 Common - exodeoxyribonuclease VII, small subunit Acid_1113 10 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 116619342 Common - HpcH/HpaI aldolase Acid_0199 74 COG3836 HpcH, 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase Carbohydrate transport and metabolism 116626184 Nonpathogen - hypothetical protein Acid_7144 1 None None None 116621521 Common - two component transcriptional regulator, winged helix family Acid_2403 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116624380 Nonpathogen - hypothetical protein Acid_5301 1 None None None 116625277 Common - NusB antitermination factor Acid_6222 155 COG0781 NusB, Transcription termination factor Transcription 116625818 Common - hypothetical protein Acid_6769 23 None None None 116624383 Common - Redoxin domain protein Acid_5304 101 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 116622073 Nonpathogen - hypothetical protein Acid_2960 2 None None None 116625461 Common - tyrosine recombinase XerD Acid_6406 230 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116620716 Nonpathogen - hypothetical protein Acid_1596 1 None None None 116626254 Common - transcriptional regulator, PadR-like family Acid_7214 50 COG1695 COG1695, Predicted transcriptional regulators Transcription 116619437 Common - A/G-specific adenine glycosylase Acid_0296 200 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 116623912 Common - ThiJ/PfpI domain protein Acid_4824 119 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 116625879 Common - transcriptional regulatory protein-like protein Acid_6833 162 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116624050 Common - hypothetical protein Acid_4964 12 None None None 116625251 Common - hypothetical protein Acid_6196 25 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116620480 Common - transcriptional regulator, LacI family Acid_1358 127 COG1609 PurR, Transcriptional regulators Transcription 116623586 Nonpathogen - DinB family protein Acid_4496 3 COG2318 DinB, Uncharacterized protein conserved in bacteria Function unknown 116625148 Common - ASPIC/UnbV domain protein Acid_6086 34 None None None 116622595 Common - Tetratricopeptide TPR_2 repeat protein Acid_3493 99 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116622411 Common - hypothetical protein Acid_3306 3 None None None 116623995 Common - Abortive infection protein Acid_4907 21 None None None 116622202 Common - Tetratricopeptide TPR_2 repeat protein Acid_3094 87 COG5616 COG5616, Predicted integral membrane protein Function unknown 116625978 Common - glycoside hydrolase, family 3 domain protein Acid_6936 119 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 116621443 Nonpathogen - hypothetical protein Acid_2325 1 None None None 116622686 Nonpathogen - hypothetical protein Acid_3585 2 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 116619170 Nonpathogen - hypothetical protein Acid_0025 1 None None None 116625942 Nonpathogen - hypothetical protein Acid_6900 1 None None None 116626180 Nonpathogen - hypothetical protein Acid_7140 2 None None None 116619532 Nonpathogen - hypothetical protein Acid_0391 2 None None None 116625975 Nonpathogen - hypothetical protein Acid_6933 1 None None None 116619929 Common - hypothetical protein Acid_0801 36 None None None 116625995 Common - Acetyl-CoA hydrolase Acid_6953 95 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 116619554 Common - alternative thymidylate synthase-like protein Acid_0415 14 COG1351 THY1, Predicted alternative thymidylate synthase Nucleotide transport and metabolism 116624420 Common - hypothetical protein Acid_5342 4 None None None 116626165 Common - Cupin 2, conserved barrel domain protein Acid_7125 27 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 116620179 Nonpathogen - transcriptional regulator, PadR-like family Acid_1052 2 COG1695 COG1695, Predicted transcriptional regulators Transcription 116623233 Common - hypothetical protein Acid_4140 4 None None None 116622870 Nonpathogen - conserved hypothetical protein, putative thiol-disulfide isomerase or thioredoxin Acid_3771 5 None None None 116622637 Common - conserved repeat domain Acid_3536 65 COG4257 Vgb, Streptogramin lyase Defense mechanisms 116626684 Common - hypothetical protein Acid_7656 4 None None None 116624241 Common - Integrase, catalytic region Acid_5158 153 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116624490 Nonpathogen - hypothetical protein Acid_5412 3 COG4745 COG4745, Predicted membrane-bound mannosyltransferase Posttranslational modification, protein turnover, chaperones 116626629 Nonpathogen - hypothetical protein Acid_7594 8 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 116623281 Common - Abortive infection protein Acid_4188 10 None None None 116619251 Common - anti-sigma-factor antagonist Acid_0107 23 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 116624790 Common - TonB-dependent receptor Acid_5714 18 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 116625737 Nonpathogen - hypothetical protein Acid_6687 1 None None None 116625802 Common - von Willebrand factor, type A Acid_6752 48 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 116625891 Common - FOG: Ankyrin repeat-like protein Acid_6845 86 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 116619167 Common - Ankyrin Acid_0022 11 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 116625654 Common - glycoside hydrolase, family 57 Acid_6603 35 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 116619995 Common - hypothetical protein Acid_0867 56 COG3665 COG3665, Uncharacterized conserved protein Function unknown 116621821 Nonpathogen - hypothetical protein Acid_2703 2 None None None 116625377 Common - elongation factor Tu Acid_6322 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 116624897 Common - permease YjgP/YjgQ family protein Acid_5821 120 COG0795 COG0795, Predicted permeases General function prediction only 116626453 Common - hypothetical protein Acid_7415 22 None None None 116620779 Common - aminotransferase, class V Acid_1660 163 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 116622393 Common - protein of unknown function DUF1486 Acid_3287 19 COG5485 COG5485, Predicted ester cyclase General function prediction only 116619405 Nonpathogen - hypothetical protein Acid_0264 9 None None None 116624030 Common - thiamine-phosphate pyrophosphorylase Acid_4942 207 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 116620603 Common - hypothetical protein Acid_1482 16 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 116623509 Common - hypothetical protein Acid_4419 10 None None None 116620825 Common - PfkB domain protein Acid_1706 65 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 116622892 Common - response regulator receiver protein Acid_3793 5 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116625531 Common - ABC transporter related Acid_6478 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 116626015 Common - carbon starvation protein CstA Acid_6973 109 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 116619629 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_0490 130 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 116624459 Common - Redoxin domain protein Acid_5381 175 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116619501 Common - Transthyretin Acid_0360 63 COG2351 COG2351, Transthyretin-like protein General function prediction only 116620115 Common - hypothetical protein Acid_0988 30 COG3571 COG3571, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 116621230 Nonpathogen - hypothetical protein Acid_2111 1 None None None 116625128 Nonpathogen - hypothetical protein Acid_6065 1 None None None 116623536 Common - metal-dependent protease of the PAD1/JAB1 superfamily-like protein Acid_4446 10 COG1310 COG1310, Predicted metal-dependent protease of the PAD1/JAB1 superfamily General function prediction only 116624676 Nonpathogen - hypothetical protein Acid_5600 18 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116625603 Common - hydrogenase expression/formation protein HypD Acid_6552 109 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 116622133 Nonpathogen - hypothetical protein Acid_3021 11 COG3664 XynB, Beta-xylosidase Carbohydrate transport and metabolism 116625716 Common - threonine dehydratase Acid_6665 197 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 116626701 Nonpathogen - hypothetical protein Acid_7673 1 COG5373 COG5373, Predicted membrane protein Function unknown 116622237 Common - protein of unknown function DUF305 Acid_3130 34 COG3544 COG3544, Uncharacterized protein conserved in bacteria Function unknown 116626948 Common - hypothetical protein Acid_7925 3 None None None 116623122 Common - metallophosphoesterase Acid_4028 25 None None None 116624059 Common - hypothetical protein Acid_4973 22 None None None 116620493 Common - NAD-dependent epimerase/dehydratase Acid_1371 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116624231 Common - transcriptional regulator, XRE family Acid_5148 23 None None None 116625800 Common - ThiJ/PfpI domain protein Acid_6750 19 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 116624201 Common - ribosomal protein L4/L1e Acid_5117 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 116625885 Common - WD40 domain protein beta Propeller Acid_6839 15 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116626521 Common - chaperone protein DnaK Acid_7484 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 116622796 Nonpathogen - hypothetical protein Acid_3696 2 None None None 116622167 Nonpathogen - hypothetical protein Acid_3059 2 None None None 116622571 Nonpathogen - hypothetical protein Acid_3469 2 None None None 116625310 Common - bifunctional deaminase-reductase domain protein Acid_6255 28 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 116626510 Common - short-chain dehydrogenase/reductase SDR Acid_7473 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116620727 Common - TonB-dependent receptor, plug Acid_1607 25 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116624701 Nonpathogen - hypothetical protein Acid_5625 3 None None None 116624653 Nonpathogen - hypothetical protein Acid_5577 1 None None None 116625760 Common - GreA/GreB family elongation factor Acid_6710 203 COG0782 GreA, Transcription elongation factor Transcription 116623870 Common - peptidase S1 and S6, chymotrypsin/Hap Acid_4782 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 116625521 Nonpathogen - hypothetical protein Acid_6468 1 None None None 116623327 Common - heme exporter protein CcmA Acid_4236 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116623693 Common - Cna B domain protein Acid_4605 23 None None None 116624248 Common - pyridoxal phosphate-dependent acyltransferase, putative Acid_5166 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 116621846 Common - Organic solvent tolerance protein Acid_2728 79 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 116622743 Common - hypothetical protein Acid_3642 23 None None None 116625809 Common - protein of unknown function DUF177 Acid_6760 47 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 116620370 Common - metallophosphoesterase Acid_1247 69 COG0622 COG0622, Predicted phosphoesterase General function prediction only 116619412 Common - glycosyl transferase, group 1 Acid_0271 83 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116623643 Common - Tetratricopeptide TPR_2 repeat protein Acid_4555 133 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116625717 Common - outer membrane protein Acid_6666 36 COG3652 COG3652, Predicted outer membrane protein Function unknown 116619648 Common - MotA/TolQ/ExbB proton channel Acid_0509 154 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 116621503 Nonpathogen - hypothetical protein Acid_2385 1 None None None 116624622 Common - 3-hydroxyacyl-CoA dehydrogenase, NAD-binding Acid_5546 164 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 116625358 Common - transcriptional regulator, XRE family Acid_6303 80 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 116626711 Common - Xylose isomerase domain protein TIM barrel Acid_7683 73 COG3622 Hfi, Hydroxypyruvate isomerase Carbohydrate transport and metabolism 116624793 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_5717 156 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116622771 Nonpathogen - hypothetical protein Acid_3670 2 None None None 116625300 Nonpathogen - hypothetical protein Acid_6245 1 None None None 116626449 Nonpathogen - hypothetical protein Acid_7411 2 None None None 116626606 Common - efflux transporter, RND family, MFP subunit Acid_7569 170 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 116625168 Common - ABC transporter related Acid_6112 249 COG3845 COG3845, ABC-type uncharacterized transport systems, ATPase components General function prediction only 116626050 Common - oxidoreductase domain protein Acid_7008 152 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116619886 Common - cysteine synthase Acid_0758 221 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 116620478 Nonpathogen - hypothetical protein Acid_1356 2 None None None 116622936 Common - protein of unknown function DUF214 Acid_3838 89 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116626495 Common - protein of unknown function DUF1078 domain protein Acid_7458 126 COG1749 FlgE, Flagellar hook protein FlgE Cell motility and secretion 116622738 Nonpathogen - hypothetical protein Acid_3637 2 None None None 116619731 Common - lipid A biosynthesis acyltransferase Acid_0596 133 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 116624990 Common - response regulator receiver protein Acid_5920 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116622536 Common - Catalase domain protein Acid_3434 85 COG0753 KatE, Catalase Inorganic ion transport and metabolism 116621614 Common - transglutaminase domain protein Acid_2496 86 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 116621058 Common - TPR repeat-containing protein Acid_1939 75 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116621126 Common - Proline dehydrogenase Acid_2007 129 COG0506 PutA, Proline dehydrogenase Amino acid transport and metabolism 116621687 Common - tRNA (guanine-N1)-methyltransferase Acid_2569 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 116620613 Common - carboxyl transferase Acid_1492 214 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 116620471 Common - Collagen triple helix repeat Acid_1349 81 COG5164 SPT5, Transcription elongation factor Transcription 116623427 Common - protein of unknown function DUF885 Acid_4336 43 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 116626623 Common - Cytochrome b/b6, N-terminal domain Acid_7586 149 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 116624304 Common - glycosyl transferase, family 28 Acid_5222 58 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 116620138 Common - histone family protein DNA-binding protein Acid_1011 24 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 116621725 Common - putative oxidoreductase Acid_2607 6 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116626383 Common - ankyrin Acid_7343 34 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 116626568 Nonpathogen - hypothetical protein Acid_7531 1 COG3861 COG3861, Uncharacterized protein conserved in bacteria Function unknown 116621313 Nonpathogen - hypothetical protein Acid_2194 1 None None None 116621222 Common - putative esterase Acid_2103 51 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 116623543 Nonpathogen - conserved hypothetical protein, transmembrane prediction Acid_4453 7 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116622137 Nonpathogen - hypothetical protein Acid_3025 2 None None None 116624141 Common - hypothetical protein Acid_5057 7 None None None 116623601 Common - Tetratricopeptide domain protein Acid_4511 27 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116622933 Nonpathogen - hypothetical protein Acid_3835 1 None None None 116625573 Common - Integrase, catalytic region Acid_6521 67 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116620401 Common - protein-export membrane protein SecD Acid_1278 220 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 116620346 Common - metal dependent phosphohydrolase Acid_1223 123 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 116622020 Common - signal transduction histidine kinase, LytS Acid_2905 104 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 116625844 Nonpathogen - hypothetical protein Acid_6797 1 None None None 116620734 Common - hypothetical protein Acid_1615 10 None None None 116621675 Common - Quinoprotein glucose dehydrogenase Acid_2557 59 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116623967 Common - Transglycosylase-associated protein Acid_4879 6 COG2261 COG2261, Predicted membrane protein Function unknown 116624288 Common - conserved hypothetical protein, transmembrane prediction Acid_5206 7 None None None 116620594 Common - major facilitator superfamily MFS_1 Acid_1473 163 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116626741 Common - CBS domain containing protein Acid_7713 222 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 116619769 Nonpathogen - hypothetical protein Acid_0636 1 None None None 116620706 Common - metallophosphoesterase Acid_1586 40 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 116621225 Common - Carboxylesterase, type B Acid_2106 72 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 116623603 Common - SMP-30/Gluconolaconase/LRE domain protein Acid_4513 42 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116619780 Common - alpha/beta hydrolase fold Acid_0650 17 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 116620307 Nonpathogen - hypothetical protein Acid_1184 3 None None None 116619287 Nonpathogen - hypothetical protein Acid_0143 1 None None None 116624497 Nonpathogen - hypothetical protein Acid_5421 3 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116625508 Common - heavy metal efflux pump, CzcA family Acid_6455 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 116622270 Common - hypothetical protein Acid_3164 4 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116624992 Common - D-3-phosphoglycerate dehydrogenase Acid_5922 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 116625673 Common - Cytochrome P450-like Acid_6622 64 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 116626484 Nonpathogen - hypothetical protein Acid_7447 1 COG1334 FlaG, Uncharacterized flagellar protein FlaG Cell motility and secretion 116621524 Nonpathogen - prevent-host-death family protein Acid_2406 4 COG4118 Phd, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 116624698 Common - NHL repeat containing protein Acid_5622 41 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116626533 Common - NAD+ synthetase Acid_7496 210 COG0171 NadE, NAD synthase Coenzyme metabolism 116620037 Common - tRNA/rRNA methyltransferase (SpoU) Acid_0909 160 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 116625436 Common - lipopolysaccharide heptosyltransferase II Acid_6381 109 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 116624660 Common - transcriptional regulator, CarD family Acid_5584 83 COG1329 COG1329, Transcriptional regulators, similar to M. xanthus CarD Transcription 116625374 Common - GrpE protein Acid_6319 4 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 116623517 Common - chromosome segregation protein SMC Acid_4427 219 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 116626753 Common - MgtC/SapB transporter Acid_7726 27 COG1285 SapB, Uncharacterized membrane protein Function unknown 116622031 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_2916 155 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116621878 Common - glycosyl transferase, family 28 Acid_2761 56 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 116624259 Common - Demethylmenaquinone methyltransferase-like protein Acid_5177 47 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 116623141 Common - ATP-dependent helicase HrpB Acid_4047 131 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 116623770 Common - hypothetical protein Acid_4682 47 COG5267 COG5267, Uncharacterized protein conserved in bacteria Function unknown 116626406 Common - hypothetical protein Acid_7368 90 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 116623434 Common - protein of unknown function DUF1211 Acid_4343 39 COG3548 COG3548, Predicted integral membrane protein Function unknown 116620439 Common - 40-residue YVTN family beta-propeller repeat protein Acid_1317 27 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116621399 Common - MscS Mechanosensitive ion channel Acid_2281 180 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 116620193 Nonpathogen - hypothetical protein Acid_1066 1 None None None 116619403 Nonpathogen - hypothetical protein Acid_0262 1 None None None 116622339 Common - protein of unknown function DUF214 Acid_3233 67 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623105 Common - transcriptional regulator, AraC family Acid_4009 211 COG2169 Ada, Adenosine deaminase Nucleotide transport and metabolism 116623636 Common - protein of unknown function DUF1003 Acid_4548 37 COG4420 COG4420, Predicted membrane protein Function unknown 116620924 Nonpathogen - hypothetical protein Acid_1805 2 None None None 116625343 Nonpathogen - hypothetical protein Acid_6288 1 None None None 116626739 Common - PhoH family protein Acid_7711 199 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 116621373 Nonpathogen - hypothetical protein Acid_2254 1 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116626954 Common - glycine cleavage T protein (aminomethyl transferase) Acid_7931 190 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 116621867 Nonpathogen - hypothetical protein Acid_2750 1 None None None 116625347 Nonpathogen - hypothetical protein Acid_6292 1 None None None 116619504 Common - hypothetical protein Acid_0363 33 COG3257 GlxB, Uncharacterized protein, possibly involved in glyoxylate utilization General function prediction only 116623001 Common - transcriptional regulator, MarR family Acid_3905 47 COG1846 MarR, Transcriptional regulators Transcription 116622259 Nonpathogen - hypothetical protein Acid_3153 1 None None None 116624363 Nonpathogen - hypothetical protein Acid_5284 1 None None None 116621480 Nonpathogen - hypothetical protein Acid_2362 1 None None None 116626865 Common - hypothetical protein Acid_7840 5 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 116622915 Common - Glutamate synthase (ferredoxin) Acid_3816 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 116620920 Nonpathogen - conserved hypothetical protein, transmembrane prediction Acid_1801 3 None None None 116625065 Nonpathogen - hypothetical protein Acid_5995 1 None None None 116624111 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_5026 29 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 116619496 Common - molybdopterin dehydrogenase, FAD-binding Acid_0355 115 COG4630 XdhA, Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A Nucleotide transport and metabolism 116623422 Common - hypothetical protein Acid_4331 35 COG4680 COG4680, Uncharacterized protein conserved in bacteria Function unknown 116625627 Common - amidohydrolase Acid_6576 28 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116621968 Nonpathogen - hypothetical protein Acid_2853 2 None None None 116624667 Common - cytochrome c oxidase, subunit III Acid_5591 150 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 116620315 Nonpathogen - hypothetical protein Acid_1192 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116625964 Common - natural resistance-associated macrophage protein Acid_6922 42 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 116624476 Common - transposase IS116/IS110/IS902 family protein Acid_5398 87 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116624027 Common - protein of unknown function DUF124 Acid_4939 77 COG2013 COG2013, Uncharacterized conserved protein Function unknown 116619155 Common - hypothetical protein Acid_0010 19 None None None 116625306 Common - Prolyl oligopeptidase Acid_6251 121 COG1505 COG1505, Serine proteases of the peptidase family S9A Amino acid transport and metabolism 116620341 Common - ribosomal protein L35 Acid_1218 164 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 116625266 Common - methionine sulfoxide reductase A Acid_6211 205 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 116623796 Common - hypothetical protein Acid_4708 9 None None None 116626692 Common - hypothetical protein Acid_7664 25 None None None 116621962 Nonpathogen - hypothetical protein Acid_2847 2 None None None 116619897 Common - DEAD/DEAH box helicase domain protein Acid_0769 179 COG1205 COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster General function prediction only 116621276 Common - protein of unknown function UPF0079 Acid_2157 208 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 116623052 Nonpathogen - hypothetical protein Acid_3956 1 None None None 116619833 Nonpathogen - transport-associated Acid_0703 2 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 116622057 Common - phage integrase family protein Acid_2943 222 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116626137 Common - ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5 Acid_7095 188 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 116620348 Common - NHL repeat containing protein Acid_1225 51 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116624266 Nonpathogen - hypothetical protein Acid_5184 1 None None None 116625506 Common - outer membrane efflux protein Acid_6453 65 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116622209 Common - Succinate-semialdehyde dehydrogenase (NAD(P)(+)) Acid_3101 84 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 116622854 Nonpathogen - hypothetical protein Acid_3754 1 None None None 116625451 Common - phenylalanyl-tRNA synthetase, alpha subunit Acid_6396 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 116624463 Common - Alcohol dehydrogenase GroES domain protein Acid_5385 205 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 116626847 Nonpathogen - Pyrrolo-quinoline quinone Acid_7820 1 COG1520 COG1520, FOG: WD40-like repeat Function unknown 116620446 Nonpathogen - hypothetical protein Acid_1324 1 None None None 116623806 Common - hypothetical protein Acid_4718 5 None None None 116621894 Common - hypothetical protein Acid_2779 10 COG4932 COG4932, Predicted outer membrane protein Cell envelope biogenesis, outer membrane 116626440 Common sdhA succinate dehydrogenase flavoprotein subunit Acid_7402 224 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 116623459 Common - hypothetical protein Acid_4369 20 COG3361 COG3361, Uncharacterized conserved protein Function unknown 116626476 Common - glycosyl transferase, family 2 Acid_7439 190 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116626718 Nonpathogen - putative FecR Acid_7690 1 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 116624826 Common - glucose-methanol-choline oxidoreductase Acid_5750 83 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 116622150 Common - xylose isomerase Acid_3042 69 COG2115 XylA, Xylose isomerase Carbohydrate transport and metabolism 116621857 Nonpathogen - hypothetical protein Acid_2740 2 None None None 116620801 Common - Superfamily I DNA and RNA helicases and helicase subunits-like protein Acid_1682 56 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 116625954 Common - Pyrrolo-quinoline quinone Acid_6912 58 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116620561 Nonpathogen - hypothetical protein Acid_1439 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116625322 Common - hypothetical protein Acid_6267 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116619922 Nonpathogen - hypothetical protein Acid_0794 8 COG0392 COG0392, Predicted integral membrane protein Function unknown 116623839 Common - putative transposase Acid_4751 31 None None None 116624972 Common - multi-sensor signal transduction histidine kinase Acid_5902 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116621003 Nonpathogen - hypothetical protein Acid_1884 3 COG5649 COG5649, Uncharacterized conserved protein Function unknown 116626355 Common - UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase Acid_7315 212 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 116626434 Common - sigma 54 modulation protein/ribosomal protein S30EA Acid_7396 70 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 116619298 Nonpathogen - hypothetical protein Acid_0154 1 None None None 116622044 Common - major facilitator superfamily MFS_1 Acid_2929 157 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 116623456 Nonpathogen - hypothetical protein Acid_4365 2 None None None 116625856 Nonpathogen - hypothetical protein Acid_6810 1 None None None 116620917 Common - hypothetical protein Acid_1798 23 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116623556 Common - beta-lactamase Acid_4466 50 COG2367 PenP, Beta-lactamase class A Defense mechanisms 116623680 Common - tRNA--hydroxylase Acid_4592 40 COG4445 MiaE, Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 116620818 Nonpathogen - zinc finger, RanBP2-type Acid_1699 4 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 116621101 Nonpathogen - hypothetical protein Acid_1982 6 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116620708 Common - Alpha-galactosidase Acid_1588 14 COG3345 GalA, Alpha-galactosidase Carbohydrate transport and metabolism 116622786 Common - DinB family protein Acid_3686 35 COG2318 DinB, Uncharacterized protein conserved in bacteria Function unknown 116623198 Common - asparagine synthase (glutamine-hydrolyzing) Acid_4105 156 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 116623450 Common - Dolichyl-phosphate beta-D-mannosyltransferase Acid_4359 162 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116625634 Nonpathogen - hypothetical protein Acid_6583 10 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 116623405 Common - serine/threonine protein kinase Acid_4314 145 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116623971 Common - Phosphosulfolactate phosphohydrolase and related enzyme-like protein Acid_4883 10 COG2045 COG2045, Phosphosulfolactate phosphohydrolase and related enzymes Coenzyme metabolism / General function prediction only 116622441 Common - aminotransferase, class I and II Acid_3339 227 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 116622482 Nonpathogen - hypothetical protein Acid_3380 2 None None None 116626900 Common - ErfK/YbiS/YcfS/YnhG family protein Acid_7877 99 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 116620498 Common - TonB-dependent receptor, plug Acid_1376 21 None None None 116621539 Common - molybdopterin dehydrogenase, FAD-binding Acid_2421 81 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 116624063 Nonpathogen - hypothetical protein Acid_4977 3 None None None 116624206 Common - 30S ribosomal protein S7 Acid_5122 248 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 116626815 Nonpathogen - hypothetical protein Acid_7788 1 None None None 116624723 Common - Alpha-N-arabinofuranosidase Acid_5647 40 COG3507 XynB, Beta-xylosidase Carbohydrate transport and metabolism 116621022 Nonpathogen - hypothetical protein Acid_1903 1 None None None 116624549 Common - hypothetical protein Acid_5473 25 None None None 116624834 Common - hypothetical protein Acid_5758 8 None None None 116625030 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding Acid_5960 47 COG0748 HugZ, Putative heme iron utilization protein Inorganic ion transport and metabolism 116622119 Common - major royal jelly protein Acid_3007 15 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116625158 Nonpathogen - hypothetical protein Acid_6099 3 COG0388 COG0388, Predicted amidohydrolase General function prediction only 116623780 Common - hypothetical protein Acid_4692 7 None None None 116625590 Common - protein of unknown function DUF500 Acid_6539 22 COG2930 COG2930, Uncharacterized conserved protein Function unknown 116626033 Common - hypothetical protein Acid_6991 17 None None None 116622693 Common - OsmC family protein Acid_3592 17 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 116625020 Nonpathogen - hypothetical protein Acid_5950 2 None None None 116623474 Common - hypothetical protein Acid_4384 12 None None None 116622189 Common - protein of unknown function DUF224, cysteine-rich region domain protein Acid_3081 104 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 116621420 Common - Ornithine cyclodeaminase Acid_2302 101 COG2423 COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog Amino acid transport and metabolism 116621346 Common - molybdopterin dehydrogenase, FAD-binding Acid_2227 83 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 116621037 Common - Activator of Hsp90 ATPase 1 family protein Acid_1918 13 COG3832 COG3832, Uncharacterized conserved protein Function unknown 116626813 Nonpathogen - hypothetical protein Acid_7786 1 COG3167 PilO, Tfp pilus assembly protein PilO Cell motility and secretion / Intracellular trafficking and secretion 116619985 Nonpathogen - hypothetical protein Acid_0857 7 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116620164 Common - protein of unknown function DUF583 Acid_1037 68 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 116621708 Common - Tetratricopeptide TPR_2 repeat protein Acid_2590 55 COG4995 COG4995, Uncharacterized protein conserved in bacteria Function unknown 116621724 Common - Cellulase Acid_2606 22 None None None 116621030 Common - phosphoglucosamine mutase Acid_1911 241 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 116620694 Common - transcriptional regulator, ArsR family Acid_1574 105 COG0640 ArsR, Predicted transcriptional regulators Transcription 116625116 Nonpathogen - hypothetical protein Acid_6053 1 None None None 116623039 Common - transposase IS116/IS110/IS902 family protein Acid_3943 87 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116626151 Common - protein of unknown function DUF214 Acid_7110 53 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622512 Common - transcriptional regulator, TetR family Acid_3410 43 COG1309 AcrR, Transcriptional regulator Transcription 116625751 Nonpathogen - hypothetical protein Acid_6701 2 None None None 116622084 Nonpathogen - hypothetical protein Acid_2971 1 None None None 116621980 Common - short-chain dehydrogenase/reductase SDR Acid_2865 234 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116619972 Common - oxidoreductase domain protein Acid_0844 101 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116623988 Common - hypothetical protein Acid_4900 25 None None None 116621646 Common - transposase IS66 Acid_2528 59 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 116621511 Common - Lytic transglycosylase, catalytic Acid_2393 121 COG4623 COG4623, Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein Cell envelope biogenesis, outer membrane 116621855 Nonpathogen - hypothetical protein Acid_2738 3 None None None 116626776 Nonpathogen - hypothetical protein Acid_7749 1 None None None 116623344 Common - hypothetical protein Acid_4253 2 None None None 116624107 Common - peptidase M28 Acid_5022 47 COG2234 Iap, Predicted aminopeptidases General function prediction only 116621129 Common - TonB-dependent receptor, plug Acid_2010 26 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116623953 Common - Phosphosulfolactate synthase Acid_4865 23 COG1809 COG1809, Uncharacterized conserved protein Function unknown 116623484 Common - Endo-1,4-beta-xylanase Acid_4394 36 COG3693 XynA, Beta-1,4-xylanase Carbohydrate transport and metabolism 116622672 Nonpathogen - hypothetical protein Acid_3571 6 COG5050 EPT1, sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Lipid metabolism 116619248 Common - Tetratricopeptide TPR_2 repeat protein Acid_0104 120 COG0457 NrfG, FOG: TPR repeat General function prediction only 116623026 Nonpathogen - Calcium-binding EF-hand-containing protein Acid_3930 3 None None None 116623981 Nonpathogen - hypothetical protein Acid_4893 1 None None None 116626043 Common - protein of unknown function DUF214 Acid_7001 9 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620545 Common - general secretion pathway protein-related protein Acid_1423 68 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 116622679 Nonpathogen - hypothetical protein Acid_3578 1 None None None 116626483 Nonpathogen - hypothetical protein Acid_7446 1 None None None 116623363 Common - protein of unknown function DUF214 Acid_4272 142 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622993 Common - iron-containing alcohol dehydrogenase Acid_3896 169 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 116624272 Common - hypothetical protein Acid_5190 4 None None None 116621353 Common - aspartate aminotransferase Acid_2234 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 116624603 Common apaG ApaG Acid_5527 89 COG2967 ApaG, Uncharacterized protein affecting Mg2+/Co2+ transport Inorganic ion transport and metabolism 116621062 Common - Xylose isomerase domain protein TIM barrel Acid_1943 44 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116623120 Nonpathogen - hypothetical protein Acid_4026 1 None None None 116625194 Nonpathogen - Xylose isomerase domain protein TIM barrel Acid_6139 9 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116626686 Common - NCS1 nucleoside transporter family Acid_7658 78 COG1953 FUI1, Cytosine/uracil/thiamine/allantoin permeases Nucleotide transport and metabolism / Coenzyme metabolism 116623645 Common - hypothetical protein Acid_4557 128 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 116626643 Common - response regulator receiver protein Acid_7609 121 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116622123 Common - NAD-dependent epimerase/dehydratase Acid_3011 231 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 116623914 Common - hypothetical protein Acid_4826 4 None None None 116623732 Common - oxidoreductase domain protein Acid_4644 88 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116619642 Common - peptidase M16 domain protein Acid_0503 164 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 116626469 Nonpathogen - hypothetical protein Acid_7432 1 COG5373 COG5373, Predicted membrane protein Function unknown 116622507 Common - glucose-methanol-choline oxidoreductase Acid_3405 86 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 116622287 Common - uroporphyrin-III C-methyltransferase Acid_3181 207 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 116623016 Common - transcriptional regulator, PadR-like family Acid_3920 35 COG1695 COG1695, Predicted transcriptional regulators Transcription 116623510 Common - YceI family protein Acid_4420 49 COG2353 COG2353, Uncharacterized conserved protein Function unknown 116619238 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_0093 90 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 116620109 Nonpathogen - hypothetical protein Acid_0982 1 None None None 116621404 Common - phosphoesterase, PA-phosphatase related Acid_2286 30 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 116623818 Common - hypothetical protein Acid_4730 3 None None None 116624923 Common - conserved hypothetical protein, possibly involved in molybdenum cofactor biosynthesis Acid_5849 89 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 116625687 Common - hypothetical protein Acid_6636 69 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 116619483 Nonpathogen - Flagellar biosynthesis/type III secretory pathway protein-like protein Acid_0342 2 COG1317 FliH, Flagellar biosynthesis/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 116620377 Common - Inositol-3-phosphate synthase Acid_1254 47 COG1260 INO1, Myo-inositol-1-phosphate synthase Lipid metabolism 116622576 Nonpathogen - hypothetical protein Acid_3474 1 None None None 116624473 Common - protein of unknown function DUF218 Acid_5395 48 COG1434 COG1434, Uncharacterized conserved protein Function unknown 116623944 Common - polysaccharide biosynthesis protein Acid_4856 9 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 116622060 Common - Resolvase, N-terminal domain Acid_2947 140 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 116625234 Nonpathogen - hypothetical protein Acid_6179 1 COG1422 COG1422, Predicted membrane protein Function unknown 116623305 Nonpathogen - hypothetical protein Acid_4212 1 COG4640 COG4640, Predicted membrane protein Function unknown 116624378 Common - DGPFAETKE family protein Acid_5299 46 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 116622007 Common - 4-alpha-glucanotransferase Acid_2892 119 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 116625616 Common - NHL repeat containing protein Acid_6565 23 None None None 116626105 Nonpathogen - YcfA family protein Acid_7063 3 COG1724 COG1724, Predicted periplasmic or secreted lipoprotein Cell motility and secretion 116622200 Common - shikimate 5-dehydrogenase Acid_3092 169 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 116621472 Common - hypothetical protein Acid_2354 137 COG1561 COG1561, Uncharacterized stress-induced protein Function unknown 116620537 Nonpathogen - hypothetical protein Acid_1415 1 None None None 116621761 Common - transcriptional repressor, CopY family Acid_2643 17 COG3682 COG3682, Predicted transcriptional regulator Transcription 116621502 Common - phage shock protein A, PspA Acid_2384 72 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 116625379 Nonpathogen - preprotein translocase, SecE subunit Acid_6324 6 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 116625894 Common - thiamine pyrophosphate enzyme domain protein TPP-binding Acid_6848 199 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 116622876 Nonpathogen - hypothetical protein Acid_3777 5 None None None 116624574 Common - protein of unknown function DUF423 Acid_5498 70 COG2363 COG2363, Uncharacterized small membrane protein Function unknown 116622157 Common - peptidase M23B Acid_3049 187 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 116624429 Common - prolipoprotein diacylglyceryl transferase Acid_5351 205 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 116621553 Common - aminotransferase class-III Acid_2435 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 116623115 Common - Activator of Hsp90 ATPase 1 family protein Acid_4020 48 COG3832 COG3832, Uncharacterized conserved protein Function unknown 116620198 Common - soluble pyridine nucleotide transhydrogenase Acid_1071 238 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 116622681 Common - NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Acid_3580 162 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 116623037 Common - putative alpha-1,6-galactosidase Acid_3941 21 COG3345 GalA, Alpha-galactosidase Carbohydrate transport and metabolism 116624095 Common - Pyrrolo-quinoline quinone Acid_5010 67 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116624717 Nonpathogen - hypothetical protein Acid_5641 1 None None None 116625762 Common - holo-acyl-carrier-protein synthase Acid_6712 166 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 116624634 Nonpathogen - hypothetical protein Acid_5558 1 None None None 116622296 Common - NusB/RsmB/TIM44 Acid_3190 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 116623390 Common - histone family protein DNA-binding protein Acid_4299 209 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 116619771 Common - hypothetical protein Acid_0639 6 None None None 116626914 Common - TonB-dependent receptor, plug Acid_7891 99 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 116619637 Common - Cytochrome-c oxidase Acid_0498 162 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 116621172 Nonpathogen - hypothetical protein Acid_2053 1 COG3047 OmpW, Outer membrane protein W Cell envelope biogenesis, outer membrane 116623110 Common - oxidoreductase domain protein Acid_4014 148 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116624931 Nonpathogen - hypothetical protein Acid_5858 1 None None None 116622328 Nonpathogen - hypothetical protein Acid_3222 4 None None None 116622622 Nonpathogen - hypothetical protein Acid_3521 1 None None None 116622719 Nonpathogen - protein of unknown function DUF1328 Acid_3618 1 None None None 116626264 Nonpathogen - hypothetical protein Acid_7224 1 None None None 116620853 Common - peptidase M16 domain protein Acid_1734 200 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 116620846 Nonpathogen - hypothetical protein Acid_1727 1 None None None 116621733 Nonpathogen - hypothetical protein Acid_2615 1 None None None 116625640 Common - AMP-dependent synthetase and ligase Acid_6589 221 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 116625934 Common - protein tyrosine phosphatase Acid_6891 9 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 116620417 Common - 2',3'-cyclic-nucleotide 2'-phosphodiesterase Acid_1294 137 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 116620397 Common - ABC-2 type transporter Acid_1274 22 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 116620753 Common - MscS Mechanosensitive ion channel Acid_1634 29 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 116623534 Nonpathogen - hypothetical protein Acid_4444 1 None None None 116621743 Common - PA14 domain protein Acid_2625 23 None None None 116622698 Nonpathogen - hypothetical protein Acid_3597 1 None None None 116624451 Nonpathogen - CheC, inhibitor of MCP methylation Acid_5373 1 COG1776 CheC, Chemotaxis protein CheC, inhibitor of MCP methylation Cell motility and secretion / Signal transduction mechanisms 116622367 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_3261 13 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116622655 Common - PfkB domain protein Acid_3554 132 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 116625356 Common - Methyltransferase type 11 Acid_6301 56 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116620702 Common - X-Pro dipeptidyl-peptidase C-terminal domain protein Acid_1582 65 COG2936 COG2936, Predicted acyl esterases General function prediction only 116625908 Common - virulence-associated E family protein Acid_6864 32 COG5545 COG5545, Predicted P-loop ATPase and inactivated derivatives General function prediction only 116626966 Nonpathogen - hypothetical protein Acid_7943 1 None None None 116624314 Common - Na+ dependent nucleoside transporter domain protein Acid_5232 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 116626085 Common - two component transcriptional regulator, winged helix family Acid_7043 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116626315 Common - pantetheine-phosphate adenylyltransferase Acid_7275 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 116625563 Common - Cytochrome-c peroxidase Acid_6510 97 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 116620615 Common - ABC-2 type transporter Acid_1494 21 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 116624895 Common - peptidase U62, modulator of DNA gyrase Acid_5819 140 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 116622092 Common - protein of unknown function DUF1080 Acid_2979 7 None None None 116622225 Common - transcriptional regulator, TetR family Acid_3118 76 COG1309 AcrR, Transcriptional regulator Transcription 116619775 Nonpathogen - hypothetical protein Acid_0645 1 None None None 116623226 Nonpathogen - hypothetical protein Acid_4133 1 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 116624804 Common - Hydroxymethylglutaryl-CoA reductase (NADPH) Acid_5728 40 COG1257 HMG1, Hydroxymethylglutaryl-CoA reductase Lipid metabolism 116626296 Common - Integrase, catalytic region Acid_7256 151 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116621145 Common clpX ATP-dependent protease ATP-binding subunit Acid_2026 231 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 116622112 Common - ABC transporter related Acid_3000 246 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 116625872 Nonpathogen - hypothetical protein Acid_6826 1 None None None 116620891 Common - PilT protein Acid_1772 16 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 116622165 Common - hypothetical protein Acid_3057 6 None None None 116623588 Common - hypothetical protein Acid_4498 9 None None None 116625525 Common - methylmalonyl-CoA mutase, large subunit Acid_6472 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 116625707 Common - amidohydrolase Acid_6656 67 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116621048 Common - LmbE family protein Acid_1929 13 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 116620527 Common - molybdenum cofactor synthesis domain Acid_1405 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 116625218 Nonpathogen - hypothetical protein Acid_6163 1 None None None 116620051 Nonpathogen - hypothetical protein Acid_0923 8 None None None 116621787 Common - cobalamin B12-binding domain protein Acid_2669 164 COG5012 COG5012, Predicted cobalamin binding protein General function prediction only 116621545 Nonpathogen - hypothetical protein Acid_2427 1 None None None 116623166 Nonpathogen - Inositol oxygenase Acid_4072 2 None None None 116624469 Common aceE pyruvate dehydrogenase subunit E1 Acid_5391 132 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 116623310 Nonpathogen - hypothetical protein Acid_4217 1 COG3847 Flp, Flp pilus assembly protein, pilin Flp Intracellular trafficking and secretion 116622341 Common - putative alpha-1,2-mannosidase Acid_3235 26 COG3537 COG3537, Putative alpha-1,2-mannosidase Carbohydrate transport and metabolism 116619866 Common - hypothetical protein Acid_0738 12 COG5316 COG5316, Uncharacterized conserved protein Function unknown 116623295 Nonpathogen - hypothetical protein Acid_4202 1 None None None 116624278 Common - Methyltransferase type 11 Acid_5196 166 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116624389 Common - Butyryl-CoA dehydrogenase Acid_5310 164 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 116620667 Common - response regulator receiver protein Acid_1547 172 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116621466 Common - hypothetical protein Acid_2348 12 COG2952 COG2952, Uncharacterized protein conserved in bacteria Function unknown 116621931 Common - glycoside hydrolase, family 16 Acid_2816 63 COG3693 XynA, Beta-1,4-xylanase Carbohydrate transport and metabolism 116619352 Nonpathogen - hypothetical protein Acid_0210 1 None None None 116623317 Nonpathogen - hypothetical protein Acid_4226 14 None None None 116620113 Nonpathogen - glycosyl transferase, family 39 Acid_0986 3 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116620878 Common - glycosyl transferase, family 2 Acid_1759 210 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116621905 Common - hypothetical protein Acid_2790 6 None None None 116622518 Common - methyl-accepting chemotaxis sensory transducer Acid_3416 122 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 116625134 Common - transcriptional regulator, TetR family Acid_6071 85 COG1309 AcrR, Transcriptional regulator Transcription 116620131 Nonpathogen - hypothetical protein Acid_1004 2 None None None 116626338 Nonpathogen - hypothetical protein Acid_7298 1 None None None 116621697 Common - Alcohol dehydrogenase GroES domain protein Acid_2579 176 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 116626786 Common - polynucleotide phosphorylase/polyadenylase Acid_7759 241 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 116619696 Nonpathogen - hypothetical protein Acid_0561 2 None None None 116624538 Common - hypothetical protein Acid_5462 4 None None None 116620428 Nonpathogen - hypothetical protein Acid_1305 1 None None None 116625050 Common - ABC transporter related Acid_5980 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 116623705 Common - hypothetical protein Acid_4617 7 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116625629 Common - Endoribonuclease L-PSP Acid_6578 179 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 116623468 Common - protein of unknown function DUF420 Acid_4378 23 COG2322 COG2322, Predicted membrane protein Function unknown 116620685 Common - GTP cyclohydrolase I Acid_1565 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 116620058 Nonpathogen - protein of unknown function DUF1552 Acid_0930 6 None None None 116622265 Common rpmA 50S ribosomal protein L27 Acid_3159 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 116620324 Common - hypothetical protein Acid_1201 21 None None None 116622146 Common - hypothetical protein Acid_3038 7 None None None 116621563 Common - peptidase M28 Acid_2445 33 COG2234 Iap, Predicted aminopeptidases General function prediction only 116624373 Common - alpha/beta hydrolase fold Acid_5294 53 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 116621319 Common - DGPFAETKE family protein Acid_2200 44 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 116626128 Common - natural resistance-associated macrophage protein Acid_7086 110 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 116622301 Common - hypothetical protein Acid_3195 78 COG2945 COG2945, Predicted hydrolase of the alpha/beta superfamily General function prediction only 116620995 Common - hypothetical protein Acid_1876 7 COG3832 COG3832, Uncharacterized conserved protein Function unknown 116623114 Common - putative transcriptional regulator, ArsR family Acid_4019 59 COG0640 ArsR, Predicted transcriptional regulators Transcription 116625405 Nonpathogen - hypothetical protein Acid_6350 1 None None None 116625922 Nonpathogen - hypothetical protein Acid_6879 1 None None None 116623822 Common - transposase IS3/IS911 family protein Acid_4734 2 None None None 116619671 Nonpathogen - hypothetical protein Acid_0534 1 COG3509 LpqC, Poly(3-hydroxybutyrate) depolymerase Secondary metabolites biosynthesis, transport, and catabolism 116622971 Common - protein of unknown function DUF1446 Acid_3874 39 None None None 116621079 Nonpathogen - hypothetical protein Acid_1960 1 None None None 116623737 Common - methyltransferase FkbM family Acid_4649 49 COG2242 CobL, Precorrin-6B methylase 2 Coenzyme metabolism 116623824 Common - TPR repeat-containing protein Acid_4736 109 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116619348 Common - Integral membrane protein TerC Acid_0206 96 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 116620317 Nonpathogen - hypothetical protein Acid_1194 12 COG4911 COG4911, Uncharacterized conserved protein Function unknown 116624954 Common - transcriptional regulator, BadM/Rrf2 family Acid_5883 170 COG1959 COG1959, Predicted transcriptional regulator Transcription 116624434 Common - OmpA/MotB domain protein Acid_5356 66 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 116625292 Common - peptidase S10, serine carboxypeptidase Acid_6237 37 COG2939 COG2939, Carboxypeptidase C (cathepsin A) Amino acid transport and metabolism 116625758 Common - dihydropteroate synthase Acid_6708 218 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 116622544 Nonpathogen - hypothetical protein Acid_3442 1 None None None 116621157 Common - FAD linked oxidase domain protein Acid_2038 130 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 116626009 Common - ABC transporter related Acid_6967 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116624529 Nonpathogen - hypothetical protein Acid_5453 1 None None None 116625851 Nonpathogen - hypothetical protein Acid_6805 1 None None None 116626594 Nonpathogen - hypothetical protein Acid_7557 2 None None None 116624561 Common - acriflavin resistance protein Acid_5485 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116621453 Common - PUA domain containing protein Acid_2335 116 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 116622829 Nonpathogen - hypothetical protein Acid_3729 1 None None None 116625016 Common - GCN5-related N-acetyltransferase Acid_5946 6 COG0456 RimI, Acetyltransferases General function prediction only 116619312 Common - methionine-R-sulfoxide reductase Acid_0169 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 116624966 Nonpathogen - hypothetical protein Acid_5896 4 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116623356 Common - Alcohol dehydrogenase, zinc-binding domain protein Acid_4265 178 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 116619491 Common - hypothetical protein Acid_0350 11 None None None 116620904 Common - protein of unknown function UPF0089 Acid_1785 28 COG4908 COG4908, Uncharacterized protein containing a NRPS condensation (elongation) domain General function prediction only 116624064 Nonpathogen - hypothetical protein Acid_4978 3 None None None 116621487 Common - binding-protein-dependent transport systems inner membrane component Acid_2369 224 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 116622069 Nonpathogen - hypothetical protein Acid_2956 1 None None None 116623756 Nonpathogen - hypothetical protein Acid_4668 1 None None None 116621264 Nonpathogen - hypothetical protein Acid_2145 1 None None None 116626206 Common - YceI family protein Acid_7166 49 COG2353 COG2353, Uncharacterized conserved protein Function unknown 116626646 Nonpathogen - hypothetical protein Acid_7612 1 None None None 116622196 Common - protein of unknown function DUF1080 Acid_3088 9 None None None 116622923 Common - amino acid permease-associated region Acid_3825 158 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116621757 Common - GCN5-related N-acetyltransferase Acid_2639 15 COG0456 RimI, Acetyltransferases General function prediction only 116623461 Common - ribosomal protein S21 Acid_4371 94 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 116620592 Common - beta-lactamase domain protein Acid_1471 97 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 116626243 Nonpathogen - hypothetical protein Acid_7203 2 None None None 116625966 Common - hydrogenase 2 protein HybA Acid_6924 162 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 116624646 Common - protein of unknown function DUF608 Acid_5570 15 COG4354 COG4354, Predicted bile acid beta-glucosidase Carbohydrate transport and metabolism 116620864 Common - multicopper oxidase, type 2 Acid_1745 122 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 116621837 Common - acetylornithine and succinylornithine aminotransferase Acid_2719 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 116623762 Nonpathogen - hypothetical protein Acid_4674 1 None None None 116625660 Nonpathogen - hypothetical protein Acid_6609 1 None None None 116625415 Nonpathogen - Septum formation initiator Acid_6360 1 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 116625544 Common - pseudouridine synthase Acid_6491 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 116626462 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase Acid_7425 211 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 116626023 Common - Dihydrodipicolinate reductase Acid_6981 194 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 116622766 Common - protein of unknown function DUF214 Acid_3665 98 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116621750 Common - metallophosphoesterase Acid_2632 141 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 116621136 Common - peptidase S9, prolyl oligopeptidase active site domain protein Acid_2017 69 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116620568 Common - response regulator receiver protein Acid_1446 203 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116621624 Common - hypothetical protein Acid_2506 13 None None None 116626768 Common - oxidoreductase domain protein Acid_7741 161 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116626732 Common - protein of unknown function DUF59 Acid_7704 156 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 116619539 Nonpathogen - glycine cleavage H-protein Acid_0398 4 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 116619521 Common - phospholipase D/Transphosphatidylase Acid_0380 156 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 116619476 Nonpathogen - hypothetical protein Acid_0335 1 None None None 116624392 Common - efflux transporter, RND family, MFP subunit Acid_5313 162 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 116621168 Common - hypothetical protein Acid_2049 20 COG3828 COG3828, Uncharacterized protein conserved in bacteria Function unknown 116624250 Common - histone family protein DNA-binding protein Acid_5168 201 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 116619270 Common - hypothetical protein Acid_0126 80 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 116626555 Nonpathogen - Forkhead-associated protein Acid_7518 1 None None None 116624528 Nonpathogen - hypothetical protein Acid_5452 17 None None None 116619177 Common - Rieske (2Fe-2S) domain protein Acid_0032 6 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 116619435 Nonpathogen - von Willebrand factor, type A Acid_0294 2 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 116623542 Nonpathogen - Xylose isomerase domain protein TIM barrel Acid_4452 5 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116619604 Common - F0F1 ATP synthase subunit beta Acid_0465 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 116622255 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_3148 28 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116625165 Common - Methyltransferase type 11 Acid_6108 123 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116619423 Nonpathogen - hypothetical protein Acid_0282 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116623204 Common - hypothetical protein Acid_4111 2 None None None 116623830 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_4742 77 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116620477 Common - monooxygenase, FAD-binding Acid_1355 18 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 116623277 Common - methionine synthase Acid_4184 181 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 116626332 Common - putative secreted protein, putative xanthan lyase related Acid_7292 33 COG2081 COG2081, Predicted flavoproteins General function prediction only 116619667 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Acid_0530 31 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 116623727 Common - lipopolysaccharide biosynthesis Acid_4639 132 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 116626501 Common - type III secretion exporter Acid_7464 130 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 116621139 Nonpathogen - hypothetical protein Acid_2020 1 None None None 116626703 Common - translation elongation factor G Acid_7675 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 116620296 Common - alpha/beta hydrolase Acid_1173 80 COG0657 Aes, Esterase/lipase Lipid metabolism 116621433 Common - LmbE family protein Acid_2315 15 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 116620940 Common - Xylose isomerase domain protein TIM barrel Acid_1821 6 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116623333 Nonpathogen - hypothetical protein Acid_4242 1 None None None 116624855 Nonpathogen - hypothetical protein Acid_5779 1 None None None 116619663 Common - Homoserine dehydrogenase Acid_0526 214 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 116619571 Nonpathogen - cytochrome c family protein Acid_0432 5 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 116621255 Common - ErfK/YbiS/YcfS/YnhG family protein Acid_2136 83 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 116620070 Common - Integrase, catalytic region Acid_0942 152 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116624508 Common - ybaK/ebsC protein Acid_5432 115 COG2606 EbsC, Uncharacterized conserved protein Function unknown 116621604 Nonpathogen - hypothetical protein Acid_2486 1 None None None 116619748 Nonpathogen - hypothetical protein Acid_0614 1 COG1579 COG1579, Zn-ribbon protein, possibly nucleic acid-binding General function prediction only 116623559 Common - Methyltransferase type 11 Acid_4469 54 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116624157 Common - FeoA family protein Acid_5073 12 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 116620660 Common - Methyltransferase type 11 Acid_1540 23 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116621606 Common - Methyltransferase type 11 Acid_2488 101 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116626429 Common - glucose/galactose transporter Acid_7391 61 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 116621810 Common - hypothetical protein Acid_2692 42 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116623683 Nonpathogen - response regulator receiver protein Acid_4595 4 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116621819 Nonpathogen - hypothetical protein Acid_2701 2 None None None 116619291 Common - GCN5-related N-acetyltransferase Acid_0147 24 COG0456 RimI, Acetyltransferases General function prediction only 116621808 Common - hypothetical protein Acid_2690 47 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116625470 Common - Lanthionine synthetase C family protein Acid_6416 14 COG4403 LcnDR2, Lantibiotic modifying enzyme Defense mechanisms 116622528 Nonpathogen - hypothetical protein Acid_3426 5 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 116622504 Common - hypothetical protein Acid_3402 2 None None None 116625289 Common - ABC-2 type transporter Acid_6234 106 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116626728 Common - FeS assembly ATPase SufC Acid_7700 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 116626392 Common - integral membrane sensor signal transduction histidine kinase Acid_7352 188 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 116619954 Common - periplasmic solute binding protein Acid_0826 166 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 116626287 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_7247 175 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116626834 Common - polysaccharide deacetylase Acid_7807 23 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 116620572 Common - Redoxin domain protein Acid_1451 163 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116620666 Common - integral membrane sensor signal transduction histidine kinase Acid_1546 222 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 116619560 Common - histidinol-phosphate phosphatase family protein Acid_0421 128 COG0241 HisB, Histidinol phosphatase and related phosphatases Amino acid transport and metabolism 116622824 Common - peptidase M28 Acid_3724 47 COG2234 Iap, Predicted aminopeptidases General function prediction only 116626147 Common - ABC transporter related Acid_7106 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116622097 Common - Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein Acid_2984 117 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116621886 Common - hypothetical protein Acid_2769 23 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 116624488 Common - hypothetical protein Acid_5410 19 COG3828 COG3828, Uncharacterized protein conserved in bacteria Function unknown 116619457 Common - DNA-3-methyladenine glycosylase Acid_0316 83 COG2094 Mpg, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 116625901 Nonpathogen - hypothetical protein Acid_6857 1 None None None 116621574 Common - protein of unknown function DUF214 Acid_2456 37 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622374 Nonpathogen - hypothetical protein Acid_3268 9 None None None 116619471 Common - flagellar hook-associated 2 domain protein Acid_0330 62 COG1345 FliD, Flagellar capping protein Cell motility and secretion 116619942 Common - amino acid permease-associated region Acid_0814 72 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116619545 Nonpathogen - hypothetical protein Acid_0404 1 None None None 116619958 Common - peptidase S15 Acid_0830 57 COG2936 COG2936, Predicted acyl esterases General function prediction only 116625917 Common - Beta-lactamase Acid_6874 50 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 116625744 Nonpathogen - hypothetical protein Acid_6694 5 None None None 116619740 Common - Penicillin amidase Acid_0605 74 COG2366 COG2366, Protein related to penicillin acylase General function prediction only 116626824 Nonpathogen - hypothetical protein Acid_7797 1 None None None 116622711 Nonpathogen - DinB Acid_3610 2 None None None 116622951 Common - HAD superfamily (subfamily IA) hydrolase, TIGR01548 Acid_3853 33 COG0546 Gph, Predicted phosphatases General function prediction only 116623829 Common - hypothetical protein Acid_4741 16 COG4299 COG4299, Uncharacterized protein conserved in bacteria Function unknown 116626549 Common - outer membrane efflux protein Acid_7512 78 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116619733 Common - phosphodiesterase, MJ0936 family Acid_0598 27 COG0622 COG0622, Predicted phosphoesterase General function prediction only 116626394 Nonpathogen - hypothetical protein Acid_7354 1 COG0729 COG0729, Outer membrane protein Cell envelope biogenesis, outer membrane 116626482 Common - UspA domain protein Acid_7445 61 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 116626269 Nonpathogen - hypothetical protein Acid_7229 1 None None None 116624516 Common - peptidase M48, Ste24p Acid_5440 121 COG4784 COG4784, Putative Zn-dependent protease General function prediction only 116624176 Common - 30S ribosomal protein S11 Acid_5092 247 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 116623549 Common - aminotransferase, class I and II Acid_4459 214 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 116623974 Common - efflux transporter, RND family, MFP subunit Acid_4886 164 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 116625873 Nonpathogen - hypothetical protein Acid_6827 1 None None None 116625652 Common - serine phosphatase Acid_6601 113 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 116624628 Common - transcriptional repressor, CopY family Acid_5552 30 COG3682 COG3682, Predicted transcriptional regulator Transcription 116626274 Nonpathogen - hypothetical protein Acid_7234 3 None None None 116624243 Nonpathogen - hypothetical protein Acid_5160 3 None None None 116624641 Common - protein of unknown function DUF892 Acid_5565 37 COG3685 COG3685, Uncharacterized protein conserved in bacteria Function unknown 116619538 Common - CoA-binding protein Acid_0397 37 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 116626614 Common - short-chain dehydrogenase/reductase SDR Acid_7577 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116619189 Common - type II secretion system protein Acid_0044 149 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 116620739 Common - hypothetical protein Acid_1620 14 None None None 116622741 Common - protein of unknown function DUF214 Acid_3640 70 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116625418 Nonpathogen - Xylose isomerase domain protein TIM barrel Acid_6363 4 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116622234 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_3127 12 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 116620012 Nonpathogen - hypothetical protein Acid_0884 4 None None None 116621567 Common - amidohydrolase 2 Acid_2449 11 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 116624335 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Acid_5253 187 COG0546 Gph, Predicted phosphatases General function prediction only 116625735 Nonpathogen - hypothetical protein Acid_6684 1 None None None 116624019 Nonpathogen - hypothetical protein Acid_4931 2 None None None 116625570 Common - hypothetical protein Acid_6517 11 None None None 116619486 Common - putative heme peroxidase Acid_0345 20 COG3253 COG3253, Uncharacterized conserved protein Function unknown 116623731 Common - DegT/DnrJ/EryC1/StrS aminotransferase Acid_4643 192 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 116626017 Nonpathogen - hypothetical protein Acid_6975 1 None None None 116620823 Nonpathogen - hypothetical protein Acid_1704 1 None None None 116620777 Common - oligopeptide transporter, OPT family Acid_1658 41 COG1297 COG1297, Predicted membrane protein Function unknown 116625714 Nonpathogen - hypothetical protein Acid_6663 9 COG1874 LacA, Beta-galactosidase Carbohydrate transport and metabolism 116621018 Common - PBS lyase HEAT domain protein repeat-containing protein Acid_1899 35 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 116621903 Common - protein of unknown function DUF1094 Acid_2788 11 None None None 116623764 Nonpathogen - hypothetical protein Acid_4676 2 None None None 116622162 Common - protein of unknown function DUF214 Acid_3054 124 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620495 Nonpathogen - hypothetical protein Acid_1373 1 None None None 116620889 Nonpathogen - type I phosphodiesterase/nucleotide pyrophosphatase Acid_1770 19 COG3379 COG3379, Uncharacterized conserved protein Function unknown 116624309 Common - outer membrane efflux protein Acid_5227 40 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116624532 Common - DNA-directed RNA polymerase, beta' subunit Acid_5456 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 116619286 Common - DoxX family protein Acid_0142 23 COG2259 COG2259, Predicted membrane protein Function unknown 116619767 Common - transposase IS3/IS911 family protein Acid_0634 32 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 116621322 Common - high-affinity nickel-transporter Acid_2203 41 COG2215 COG2215, ABC-type uncharacterized transport system, permease component General function prediction only 116624356 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_5276 27 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 116621723 Common - protein of unknown function DUF1080 Acid_2605 10 None None None 116624045 Common - multi-sensor hybrid histidine kinase Acid_4959 223 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116622071 Nonpathogen - hypothetical protein Acid_2958 1 None None None 116620552 Common - transcriptional regulator, MerR family Acid_1430 27 COG0789 SoxR, Predicted transcriptional regulators Transcription 116622966 Common - response regulator receiver protein Acid_3869 90 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116621273 Common - metallophosphoesterase Acid_2154 20 COG1409 Icc, Predicted phosphohydrolases General function prediction only 116623164 Common - 3-isopropylmalate dehydratase, small subunit Acid_4070 212 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 116623872 Common - SSS sodium solute transporter superfamily Acid_4784 138 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 116623609 Common - putative nicotinate phosphoribosyltransferase Acid_4519 126 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 116621653 Common - Guanine deaminase Acid_2535 207 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 116620907 Nonpathogen - hypothetical protein Acid_1788 2 None None None 116623612 Common - DoxX family protein Acid_4522 23 COG2259 COG2259, Predicted membrane protein Function unknown 116623709 Nonpathogen - hypothetical protein Acid_4621 2 None None None 116621506 Common - transcriptional regulator, PadR-like family Acid_2388 58 COG1695 COG1695, Predicted transcriptional regulators Transcription 116621550 Nonpathogen - DinB family protein Acid_2432 4 COG2318 DinB, Uncharacterized protein conserved in bacteria Function unknown 116620053 Common - SSS sodium solute transporter superfamily Acid_0925 157 COG4147 DhlC, Predicted symporter General function prediction only 116625783 Common - short-chain dehydrogenase/reductase SDR Acid_6733 91 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116619264 Common - proton-translocating NADH-quinone oxidoreductase, chain N Acid_0120 210 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 116621758 Common - glycosyl transferase, family 28 Acid_2640 43 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 116620732 Common - PAAR repeat-containing protein Acid_1613 33 COG4104 COG4104, Uncharacterized conserved protein Function unknown 116625434 Nonpathogen - hypothetical protein Acid_6379 1 None None None 116625996 Common - LAO/AO transport system ATPase Acid_6954 99 COG1703 ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family Amino acid transport and metabolism 116622104 Common - putative esterase Acid_2991 46 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 116622846 Common - serine/threonine protein kinase with TPR repeats Acid_3746 182 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116620294 Common - signal peptidase I Acid_1171 186 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 116625175 Common - putative transposase Acid_6119 29 None None None 116619991 Common - binding-protein-dependent transport systems inner membrane component Acid_0863 102 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 116622638 Common - peptidase M24 Acid_3537 202 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 116625605 Common - hydrogenase expression/formation protein HypE Acid_6554 137 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 116625477 Common - hypothetical protein Acid_6423 4 COG5562 COG5562, Phage envelope protein General function prediction only 116622143 Nonpathogen - hypothetical protein Acid_3035 1 None None None 116621311 Nonpathogen - hypothetical protein Acid_2192 1 COG4944 COG4944, Uncharacterized protein conserved in bacteria Function unknown 116626605 Common - acriflavin resistance protein Acid_7568 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116621447 Nonpathogen - hypothetical protein Acid_2329 1 None None None 116622959 Common - putative lipase/esterase Acid_3861 38 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116623503 Common - ABC transporter related Acid_4413 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116623884 Common - transcriptional regulator, PadR-like family Acid_4796 41 COG1695 COG1695, Predicted transcriptional regulators Transcription 116624106 Common - PAS/PAC sensor hybrid histidine kinase Acid_5021 218 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116620591 Nonpathogen - hypothetical protein Acid_1470 1 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 116622366 Common - putative transposase protein, Y4bF Acid_3260 20 None None None 116623234 Common - putative transmembrane protein Acid_4141 2 None None None 116624558 Common - protein of unknown function DUF497 Acid_5482 11 COG2929 COG2929, Uncharacterized protein conserved in bacteria Function unknown 116621612 Common - hypothetical protein Acid_2494 47 None None None 116619289 Common - GCN5-related N-acetyltransferase Acid_0145 26 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 116623240 Common - peptidylprolyl isomerase, FKBP-type Acid_4147 144 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 116620474 Common - multi-sensor hybrid histidine kinase Acid_1352 218 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116624189 Common - ribosomal protein S14 Acid_5105 203 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 116625287 Nonpathogen - hypothetical protein Acid_6232 1 None None None 116622026 Common - aldo/keto reductase Acid_2911 205 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116619254 Common - NADH (or F420H2) dehydrogenase, subunit C Acid_0110 180 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 116620194 Common - dihydrodipicolinate synthetase Acid_1067 234 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 116620675 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Acid_1555 201 COG0388 COG0388, Predicted amidohydrolase General function prediction only 116625841 Common - hypothetical protein Acid_6794 27 None None None 116620751 Nonpathogen - hypothetical protein Acid_1632 2 None None None 116622931 Common - hypothetical protein Acid_3833 13 None None None 116624233 Common - hemerythrin-like metal-binding protein Acid_5150 33 COG2703 COG2703, Hemerythrin Inorganic ion transport and metabolism 116624796 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_5720 166 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116622211 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Acid_3103 113 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116623441 Nonpathogen - hypothetical protein Acid_4350 2 COG4030 COG4030, Uncharacterized protein conserved in archaea Function unknown 116624703 Nonpathogen - hypothetical protein Acid_5627 1 COG4297 COG4297, Uncharacterized protein containing double-stranded beta helix domain Function unknown 116625035 Common - hypothetical protein Acid_5965 42 COG2374 COG2374, Predicted extracellular nuclease General function prediction only 116621916 Common - Gluconolactonase Acid_2801 68 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116619389 Common - coenzyme A transferase Acid_0248 55 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 116621212 Common - TonB-dependent receptor Acid_2093 18 None None None 116620500 Nonpathogen - hypothetical protein Acid_1378 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116621571 Common - Transketolase domain protein Acid_2453 220 COG3959 COG3959, Transketolase, N-terminal subunit Carbohydrate transport and metabolism 116623640 Common - signal peptidase I Acid_4552 212 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 116624323 Common - protein of unknown function DUF323 Acid_5241 113 COG1262 COG1262, Uncharacterized conserved protein Function unknown 116625679 Common - Radical SAM domain protein Acid_6628 100 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116624506 Common - peptidase S9, prolyl oligopeptidase active site domain protein Acid_5430 137 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116625301 Nonpathogen - hypothetical protein Acid_6246 1 None None None 116619531 Common - 4-hydroxythreonine-4-phosphate dehydrogenase Acid_0390 159 COG1995 PdxA, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 116622131 Common - Nucleotidyl transferase Acid_3019 127 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 116626065 Nonpathogen - hypothetical protein Acid_7023 1 None None None 116622272 Common - conserved hypothetical protein 103 Acid_3166 90 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 116619639 Nonpathogen - caa(3)-type oxidase, subunit IV Acid_0500 1 None None None 116623769 Common - protein of unknown function DUF1501 Acid_4681 48 COG4102 COG4102, Uncharacterized protein conserved in bacteria Function unknown 116624495 Common - polysaccharide deacetylase Acid_5417 75 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 116619447 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_0306 4 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116624052 Nonpathogen - hypothetical protein Acid_4966 1 None None None 116625271 Common - 3-deoxy-manno-octulosonate cytidylyltransferase Acid_6216 150 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 116624994 Common - NHL repeat containing protein Acid_5924 44 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116619419 Common - hypothetical protein Acid_0278 2 None None None 116620300 Common - deoxyhypusine synthase Acid_1177 48 COG1899 DYS1, Deoxyhypusine synthase Posttranslational modification, protein turnover, chaperones 116626783 Common - Tetratricopeptide TPR_2 repeat protein Acid_7756 70 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116620136 Common - DNA primase Acid_1009 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 116622426 Common - hypothetical protein Acid_3323 8 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116623128 Nonpathogen - TonB-dependent receptor Acid_4034 2 None None None 116622201 Common - major facilitator superfamily MFS_1 Acid_3093 193 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116623288 Common - Tetratricopeptide TPR_2 repeat protein Acid_4195 142 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116620715 Common - band 7 protein Acid_1595 201 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 116626349 Common - Polypeptide-transport-associated domain protein, FtsQ-type Acid_7309 27 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 116619904 Common - short-chain dehydrogenase/reductase SDR Acid_0776 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 116621610 Common - protein of unknown function DUF214 Acid_2492 68 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623134 Common - hypothetical protein Acid_4040 24 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116625280 Common - LmbE family protein Acid_6225 10 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 116622699 Nonpathogen - hypothetical protein Acid_3598 3 None None None 116625279 Common - Enoyl-CoA hydratase/isomerase Acid_6224 182 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 116619998 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_0870 13 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116619795 Common - hypothetical protein Acid_0665 12 None None None 116619332 Common - hypothetical protein Acid_0189 17 None None None 116624331 Common - hypothetical protein Acid_5249 16 COG5665 NOT5, CCR4-NOT transcriptional regulation complex, NOT5 subunit Transcription 116625406 Nonpathogen - hypothetical protein Acid_6351 1 None None None 116621981 Common - hypothetical protein Acid_2866 10 None None None 116621658 Nonpathogen - hypothetical protein Acid_2540 1 None None None 116625860 Common - hypothetical protein Acid_6814 20 COG3202 COG3202, ATP/ADP translocase Energy production and conversion 116623748 Common - NusG antitermination factor Acid_4660 53 COG0250 NusG, Transcription antiterminator Transcription 116624650 Common - PIN domain protein Acid_5574 4 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 116620309 Common - squalene-hopene cyclase Acid_1186 42 COG1657 SqhC, Squalene cyclase Lipid metabolism 116620325 Common - hypothetical protein Acid_1202 8 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 116623047 Common - sulfatase Acid_3951 89 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116625493 Common - hypothetical protein Acid_6439 10 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 116624162 Common - hypothetical protein Acid_5078 11 COG3170 FimV, Tfp pilus assembly protein FimV Cell motility and secretion / Intracellular trafficking and secretion 116621899 Common - hypothetical protein Acid_2784 10 None None None 116623817 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Acid_4729 2 None None None 116622382 Common - penicillin-binding protein, transpeptidase Acid_3276 206 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 116619367 Common - protein of unknown function DUF876 Acid_0225 49 COG3522 COG3522, Uncharacterized protein conserved in bacteria Function unknown 116620565 Common - ATP/ADP translocase-like protein Acid_1443 24 COG3202 COG3202, ATP/ADP translocase Energy production and conversion 116624415 Common - hypothetical protein Acid_5337 5 None None None 116623002 Common - oxidoreductase domain protein Acid_3906 89 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116626386 Common - hypothetical protein Acid_7346 4 None None None 116626291 Nonpathogen - hypothetical protein Acid_7251 1 None None None 116624868 Nonpathogen - hypothetical protein Acid_5792 2 None None None 116622562 Common - ABC transporter related protein Acid_3460 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 116623404 Common - protein serine/threonine phosphatase Acid_4313 130 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 116624317 Common - amidohydrolase Acid_5235 176 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 116619524 Nonpathogen - hypothetical protein Acid_0383 1 None None None 116624143 Common - hypothetical protein Acid_5059 6 None None None 116619226 Common - metallophosphoesterase Acid_0081 34 COG1409 Icc, Predicted phosphohydrolases General function prediction only 116625638 Common - short-chain dehydrogenase/reductase SDR Acid_6587 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116620632 Common - amidohydrolase 2 Acid_1511 19 COG3618 COG3618, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 116623073 Common - hypothetical protein Acid_3977 19 None None None 116622930 Common - hypothetical protein Acid_3832 5 None None None 116619203 Common - aspartate aminotransferase Acid_0058 239 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 116624015 Common - diguanylate phosphodiesterase Acid_4927 78 COG3434 COG3434, Predicted signal transduction protein containing EAL and modified HD-GYP domains Signal transduction mechanisms 116625229 Common - transcriptional regulator, TraR/DksA family Acid_6174 121 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 116620170 Common - UTP-glucose-1-phosphate uridylyltransferase GalU Acid_1043 232 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 116621025 Common - UvrD/REP helicase Acid_1906 228 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 116624819 Common - von Willebrand factor, type A Acid_5743 74 COG2304 COG2304, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 116626356 Common - UDP-N-acetylmuramyl-tripeptide synthetase Acid_7316 210 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 116621341 Common - Alcohol dehydrogenase GroES domain protein Acid_2222 207 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 116621056 Common - protein of unknown function DUF362 Acid_1937 32 COG2006 COG2006, Uncharacterized conserved protein Function unknown 116619283 Common - TonB-dependent receptor, plug Acid_0139 19 None None None 116625420 Nonpathogen - hypothetical protein Acid_6365 1 COG5373 COG5373, Predicted membrane protein Function unknown 116621088 Common - amidohydrolase Acid_1969 76 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116620605 Common - Xylose isomerase domain protein TIM barrel Acid_1484 60 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116623283 Common - von Willebrand factor, type A Acid_4190 13 COG2425 COG2425, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 116619723 Common - sigma54 specific transcriptional regulator, Fis family Acid_0588 162 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 116624738 Common - protein of unknown function DUF163 Acid_5662 166 COG1576 COG1576, Uncharacterized conserved protein Function unknown 116625090 Nonpathogen - hypothetical protein Acid_6025 1 None None None 116623593 Nonpathogen - hypothetical protein Acid_4503 1 None None None 116620094 Common - ferredoxin, 2Fe-2S Acid_0966 83 COG3411 COG3411, Ferredoxin Energy production and conversion 116624591 Common - PIN domain family protein Acid_5515 8 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 116624726 Nonpathogen - hypothetical protein Acid_5650 2 None None None 116623993 Nonpathogen - hypothetical protein Acid_4905 1 None None None 116622683 Common - hypothetical protein Acid_3582 14 COG4262 COG4262, Predicted spermidine synthase with an N-terminal membrane domain General function prediction only 116626348 Common - cell division protein FtsA Acid_7308 184 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 116619334 Common - major facilitator superfamily MFS_1 Acid_0191 206 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116624382 Common - KWG Leptospira repeat protein Acid_5303 24 None None None 116619382 Common - Rhs element Vgr protein Acid_0240 61 COG3501 VgrG, Uncharacterized protein conserved in bacteria Function unknown 116623937 Common - Radical SAM domain protein Acid_4849 99 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 116620025 Nonpathogen - prevent-host-death family protein Acid_0897 2 None None None 116625369 Common - GCN5-related N-acetyltransferase Acid_6314 17 COG3153 COG3153, Predicted acetyltransferase General function prediction only 116624226 Common - oxidoreductase domain protein Acid_5142 181 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116619628 Common - chaperone protein HtpG Acid_0489 26 None None None 116625316 Common - NHL repeat containing protein Acid_6261 126 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116621202 Common - hypothetical protein Acid_2083 22 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116622890 Common - Collagen triple helix repeat Acid_3791 2 None None None 116623124 Common - ABC transporter related Acid_4030 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 116624346 Common - protein of unknown function DUF355 Acid_5266 33 COG1839 COG1839, Uncharacterized conserved protein Function unknown 116619938 Nonpathogen - hypothetical protein Acid_0810 1 None None None 116623633 Nonpathogen - TadE family protein Acid_4545 2 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 116619867 Common - NHL repeat containing protein Acid_0739 31 None None None 116623311 Nonpathogen - Flp/Fap pilin component Acid_4218 1 COG3847 Flp, Flp pilus assembly protein, pilin Flp Intracellular trafficking and secretion 116622053 Nonpathogen - hypothetical protein Acid_2939 1 None None None 116622414 Common - phage integrase family protein Acid_3310 203 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116623058 Common - short-chain dehydrogenase/reductase SDR Acid_3962 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116624896 Nonpathogen - peptidase U62, modulator of DNA gyrase Acid_5820 11 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 116625750 Common - formamidopyrimidine-DNA glycosylase Acid_6700 184 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 116626799 Nonpathogen - hypothetical protein Acid_7772 7 None None None 116620250 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_1127 13 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116620725 Common - protein of unknown function DUF81 Acid_1605 39 COG0730 COG0730, Predicted permeases General function prediction only 116622657 Nonpathogen - Haloacid dehalogenase domain protein hydrolase Acid_3556 2 COG0546 Gph, Predicted phosphatases General function prediction only 116623185 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_4092 164 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116626792 Common - DNA ligase, NAD-dependent Acid_7765 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 116622491 Common - transcriptional regulator, TraR/DksA family Acid_3389 119 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 116622644 Nonpathogen - hypothetical protein Acid_3543 14 None None None 116625354 Common - tRNA pseudouridine synthase B Acid_6299 245 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 116625073 Common - transposase IS66 Acid_6003 57 COG2251 COG2251, Predicted nuclease (RecB family) General function prediction only 116625706 Common - hypothetical protein Acid_6655 19 None None None 116625075 Nonpathogen - hypothetical protein Acid_6006 1 None None None 116623067 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Acid_3971 195 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 116620045 Common - cold-shock DNA-binding domain protein Acid_0917 177 COG1278 CspC, Cold shock proteins Transcription 116620516 Nonpathogen - hypothetical protein Acid_1394 5 None None None 116620770 Common - putative metal-dependent hydrolase Acid_1651 61 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 116625207 Nonpathogen - hypothetical protein Acid_6152 1 None None None 116625786 Common - monooxygenase, FAD-binding Acid_6736 111 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 116625236 Nonpathogen - type I phosphodiesterase/nucleotide pyrophosphatase Acid_6181 23 COG3379 COG3379, Uncharacterized conserved protein Function unknown 116625698 Common - hypothetical protein Acid_6647 27 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116623362 Nonpathogen - hypothetical protein Acid_4271 1 None None None 116621791 Common - homocysteine S-methyltransferase Acid_2673 164 COG0646 MetH, Methionine synthase I (cobalamin-dependent), methyltransferase domain Amino acid transport and metabolism 116626227 Common - TPR repeat-containing protein Acid_7187 150 COG0457 NrfG, FOG: TPR repeat General function prediction only 116623671 Nonpathogen - response regulator receiver protein Acid_4583 1 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116621824 Common - Methyltransferase type 11 Acid_2706 218 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116621148 Common rho transcription termination factor Rho Acid_2029 205 COG1158 Rho, Transcription termination factor Transcription 116620745 Common - hypothetical protein Acid_1626 4 None None None 116625920 Nonpathogen - Fibronectin, type III domain protein Acid_6877 6 None None None 116623719 Common - NAD-dependent epimerase/dehydratase Acid_4631 221 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116624919 Common - S1/P1 nuclease Acid_5845 22 None None None 116624575 Nonpathogen - hypothetical protein Acid_5499 1 None None None 116624878 Common - hypothetical protein Acid_5802 16 None None None 116619275 Nonpathogen - hypothetical protein Acid_0131 2 None None None 116625049 Common - Penicillin amidase Acid_5979 79 COG2366 COG2366, Protein related to penicillin acylase General function prediction only 116622318 Nonpathogen - hypothetical protein Acid_3212 1 None None None 116624291 Common - urocanate hydratase Acid_5209 97 COG2987 HutU, Urocanate hydratase Amino acid transport and metabolism 116624946 Common - phytoene dehydrogenase, putative Acid_5875 56 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 116626821 Common - hypothetical protein Acid_7794 3 None None None 116620205 Common - oxidoreductase Acid_1078 85 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116623852 Nonpathogen - hypothetical protein Acid_4764 1 None None None 116626893 Common - integral membrane sensor hybrid histidine kinase Acid_7870 222 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116621546 Nonpathogen - hypothetical protein Acid_2428 1 None None None 116621798 Common - sugar (Glycoside-Pentoside-Hexuronide) transporter Acid_2680 82 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 116619163 Common - transcriptional regulator, MerR family Acid_0018 100 COG0789 SoxR, Predicted transcriptional regulators Transcription 116623446 Common - hypothetical protein Acid_4355 7 None None None 116624580 Nonpathogen - hypothetical protein Acid_5504 1 None None None 116621064 Common - Cna B domain protein Acid_1945 24 None None None 116625099 Nonpathogen - hypothetical protein Acid_6035 2 None None None 116622290 Common - transcriptional regulator, Crp/Fnr family Acid_3184 121 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 116621338 Common - response regulator receiver protein Acid_2219 216 COG0784 CheY, FOG: CheY-like receiver Signal transduction mechanisms 116622750 Common - molybdopterin dehydrogenase, FAD-binding Acid_3649 75 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 116626577 Nonpathogen - hypothetical protein Acid_7951 1 None None None 116621582 Common - serine/threonine protein kinase Acid_2464 169 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116624965 Common - integral membrane sensor hybrid histidine kinase Acid_5895 218 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116619790 Common - Methyltransferase type 11 Acid_0660 16 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116624083 Nonpathogen - hypothetical protein Acid_4997 1 None None None 116625552 Common - peptidase M24 Acid_6499 233 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 116620796 Nonpathogen - hypothetical protein Acid_1677 1 None None None 116626924 Common - two component transcriptional regulator, LuxR family Acid_7901 207 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116623905 Nonpathogen - hypothetical protein Acid_4817 1 None None None 116620865 Common - hypothetical protein Acid_1746 14 None None None 116624285 Common - Ferrochelatase Acid_5203 152 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 116620276 Common lpxC UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase Acid_1153 139 COG0774 LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase Cell envelope biogenesis, outer membrane 116621467 Common - major facilitator superfamily MFS_1 Acid_2349 173 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116626211 Nonpathogen - hypothetical protein Acid_7171 1 None None None 116620278 Common - HAD-superfamily hydrolase, subfamily IIB Acid_1155 83 COG1877 OtsB, Trehalose-6-phosphatase Carbohydrate transport and metabolism 116622598 Common - ASPIC/UnbV domain protein Acid_3496 32 None None None 116619371 Common - methyltransferase small Acid_0229 93 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 116622250 Common - glycogen debranching enzyme, putative Acid_3143 59 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 116621960 Common - DEAD/H associated domain protein Acid_2845 157 COG1201 Lhr, Lhr-like helicases General function prediction only 116621281 Nonpathogen - hypothetical protein Acid_2162 1 None None None 116625125 Nonpathogen - hypothetical protein Acid_6062 1 None None None 116624322 Nonpathogen - hypothetical protein Acid_5240 1 None None None 116625757 Common - tyrosyl-tRNA synthetase Acid_6707 240 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116620489 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_1367 12 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116623151 Common - glycoside hydrolase, family 28 Acid_4057 27 COG5434 PGU1, Endopygalactorunase Cell envelope biogenesis, outer membrane 116619590 Common - FAD linked oxidase domain protein Acid_0451 158 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 116621533 Nonpathogen - hypothetical protein Acid_2415 1 None None None 116624924 Common - protein of unknown function DUF182 Acid_5850 122 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 116621493 Common - peptidase S41 Acid_2375 12 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 116621560 Common - short-chain dehydrogenase/reductase SDR Acid_2442 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116621677 Common - sodium/glutamate symporter Acid_2559 51 COG0786 GltS, Na+/glutamate symporter Amino acid transport and metabolism 116619851 Common - N-acetyl-gamma-glutamyl-phosphate reductase Acid_0723 215 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 116622297 Common - Ribulose-phosphate 3-epimerase Acid_3191 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 116622985 Nonpathogen - hypothetical protein Acid_3888 2 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 116623663 Common - NIPSNAP family containing protein Acid_4575 18 None None None 116623099 Common - TonB-dependent receptor Acid_4003 25 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116626898 Common - extracellular solute-binding protein, family 5 Acid_7875 6 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 116620008 Common - peptidase M28 Acid_0880 40 COG2234 Iap, Predicted aminopeptidases General function prediction only 116622700 Common - Redoxin domain protein Acid_3599 228 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116621663 Common - protein of unknown function DUF214 Acid_2545 80 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116626621 Common - cytochrome c, class I Acid_7584 23 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 116625202 Nonpathogen - hypothetical protein Acid_6147 4 COG2006 COG2006, Uncharacterized conserved protein Function unknown 116626078 Nonpathogen - nucleotidyltransferase/DNA polymerase involved in DNA repair-like protein Acid_7036 2 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 116626717 Common - ABC transporter related Acid_7689 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116620761 Common - TonB-dependent receptor Acid_1642 24 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116620573 Nonpathogen - hypothetical protein Acid_1452 1 COG2134 Cdh, CDP-diacylglycerol pyrophosphatase Lipid metabolism 116623755 Common - Tetratricopeptide TPR_2 repeat protein Acid_4667 144 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116620289 Common - electron transfer flavoprotein beta-subunit Acid_1166 152 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 116621778 Common - glycoside hydrolase, family 3 domain protein Acid_2660 102 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 116621115 Common - AAA ATPase Acid_1996 30 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 116622868 Nonpathogen - hypothetical protein Acid_3769 1 None None None 116621802 Common - histidine kinase Acid_2684 146 COG3292 COG3292, Predicted periplasmic ligand-binding sensor domain Signal transduction mechanisms 116620282 Common - Spermine synthase Acid_1159 106 COG4262 COG4262, Predicted spermidine synthase with an N-terminal membrane domain General function prediction only 116623203 Nonpathogen - hypothetical protein Acid_4110 1 None None None 116619328 Common - nitrite reductase (NAD(P)H), small subunit Acid_0185 82 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 116620611 Common - selenocysteine-specific translation elongation factor Acid_1490 249 COG3276 SelB, Selenocysteine-specific translation elongation factor Translation, ribosomal structure and biogenesis 116625579 Common - TadE family protein Acid_6528 5 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 116625867 Common - ATP dependent DNA ligase Acid_6821 107 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 116621327 Common - magnesium protoporphyrin chelatase, putative Acid_2208 46 COG1239 ChlI, Mg-chelatase subunit ChlI Coenzyme metabolism 116626637 Common - hypothetical protein Acid_7602 61 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 116624674 Common - NmrA family protein Acid_5598 52 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116624214 Common - beta-lactamase domain protein Acid_5130 37 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 116624352 Common - transcriptional regulator, ArsR family Acid_5272 191 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116623491 Common - hypothetical protein Acid_4401 10 None None None 116626324 Common - Glycosyl hydrolase family 32, N terminal domain protein Acid_7284 14 COG1621 SacC, Beta-fructosidases (levanase/invertase) Carbohydrate transport and metabolism 116621239 Common - Alpha-N-arabinofuranosidase Acid_2120 6 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 116621922 Common - gamma-glutamyltransferase Acid_2807 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 116622744 Common - Sel1 domain protein repeat-containing protein Acid_3643 12 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 116624767 Common - respiratory-chain NADH dehydrogenase, subunit 1 Acid_5691 188 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 116619701 Nonpathogen - hypothetical protein Acid_0566 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116626194 Nonpathogen - sulfatase Acid_7154 1 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116619243 Nonpathogen - hypothetical protein Acid_0099 3 None None None 116620435 Common - hypothetical protein Acid_1313 11 None None None 116625117 Nonpathogen - hypothetical protein Acid_6054 1 None None None 116625778 Common - natural resistance-associated macrophage protein Acid_6728 108 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 116623710 Common - Homoserine O-acetyltransferase Acid_4622 127 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 116622285 Common - porphobilinogen deaminase Acid_3179 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 116626957 Nonpathogen - hypothetical protein Acid_7934 1 None None None 116621197 Common - transcriptional regulator, GntR family Acid_2078 146 COG1609 PurR, Transcriptional regulators Transcription 116619860 Common - heat-inducible transcription repressor HrcA Acid_0732 151 COG1420 HrcA, Transcriptional regulator of heat shock gene Transcription 116622391 Nonpathogen - hypothetical protein Acid_3285 1 None None None 116624274 Common - selenium-binding protein Acid_5192 18 None None None 116624861 Nonpathogen - hypothetical protein Acid_5785 1 None None None 116622456 Common - protein of unknown function DUF111 Acid_3354 64 COG1641 COG1641, Uncharacterized conserved protein Function unknown 116626943 Common - protein of unknown function DUF214 Acid_7920 72 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 116622844 Common - protein of unknown function DUF1549 Acid_3744 10 COG3748 COG3748, Predicted membrane protein Function unknown 116623925 Nonpathogen - hypothetical protein Acid_4837 1 None None None 116621940 Common - hypothetical protein Acid_2825 4 None None None 116623386 Common - response regulator receiver modulated serine phosphatase Acid_4295 193 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 116621945 Common - Methyltransferase type 12 Acid_2830 16 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 116623947 Common - sugar transferase Acid_4859 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 116622878 Common - NADH-quinone oxidoreductase, B subunit Acid_3779 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 116623382 Common - integral membrane sensor hybrid histidine kinase Acid_4291 225 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116626503 Common - GTP-binding signal recognition particle SRP54, G- domain Acid_7466 244 COG1419 FlhF, Flagellar GTP-binding protein Cell motility and secretion 116620973 Nonpathogen - hypothetical protein Acid_1854 3 None None None 116625925 Nonpathogen - hypothetical protein Acid_6882 1 None None None 116619326 Common - molybdopterin oxidoreductase Acid_0183 193 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 116626584 Nonpathogen - hypothetical protein Acid_7547 1 None None None 116625741 Common - inosine-5'-monophosphate dehydrogenase Acid_6691 241 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 116624691 Common - molecular chaperone Acid_5615 230 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 116626427 Common - 3-oxoacyl-(acyl-carrier-protein) synthase Acid_7389 213 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 116621990 Common - aminotransferase, class V Acid_2875 221 COG3844 COG3844, Kynureninase Amino acid transport and metabolism 116623965 Common - hypothetical protein Acid_4877 30 COG5164 SPT5, Transcription elongation factor Transcription 116623376 Common - DNA polymerase, beta domain protein region Acid_4285 26 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 116621991 Common - polyhydroxyalkanoate depolymerase precursor-like protein Acid_2876 10 None None None 116620526 Common - molybdenum cofactor biosynthesis protein C Acid_1404 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 116619630 Common - Polysulphide reductase, NrfD Acid_0491 36 COG5557 COG5557, Polysulphide reductase Energy production and conversion 116621628 Common - beta-lactamase Acid_2510 151 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 116626952 Common - beta-lactamase domain protein Acid_7929 222 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 116624267 Common - von Willebrand factor, type A Acid_5185 29 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 116625269 Common - 2-dehydro-3-deoxyphosphooctonate aldolase Acid_6214 186 COG2877 KdsA, 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase Cell envelope biogenesis, outer membrane 116619586 Common - amidohydrolase 2 Acid_0447 7 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 116620445 Common - hypothetical protein Acid_1323 2 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 116623812 Common - orotidine 5'-phosphate decarboxylase Acid_4724 172 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 116619761 Common - hypothetical protein Acid_0627 9 None None None 116620083 Common - protein of unknown function DUF558 Acid_0955 200 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 116621114 Nonpathogen - N-acetylmuramoyl-L-alanine amidase, family 2 Acid_1995 1 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 116620169 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_1042 144 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 116622349 Nonpathogen - hypothetical protein Acid_3243 5 None None None 116620651 Common - integral membrane protein MviN Acid_1531 190 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 116621291 Nonpathogen - hypothetical protein Acid_2172 3 None None None 116624187 Common - ribosomal protein L6 Acid_5103 219 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 116626907 Common - Prephenate dehydrogenase Acid_7884 154 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 116621633 Common - Alanine--glyoxylate transaminase Acid_2515 158 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 116623849 Common - Glu/Leu/Phe/Val dehydrogenase, C terminal Acid_4761 180 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 116621617 Common - protein of unknown function DUF404 Acid_2499 89 COG2308 COG2308, Uncharacterized conserved protein Function unknown 116623842 Common - transcriptional regulator, PadR-like family Acid_4754 73 COG1695 COG1695, Predicted transcriptional regulators Transcription 116625514 Common - two component transcriptional regulator, LuxR family Acid_6461 211 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116621298 Nonpathogen - hypothetical protein Acid_2179 1 None None None 116620035 Common - ribosomal protein S9 Acid_0907 244 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 116620689 Common - phosphatidylglycerophosphatase A Acid_1569 105 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 116625000 Common - short-chain dehydrogenase/reductase SDR Acid_5930 238 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 116620961 Nonpathogen - hypothetical protein Acid_1842 1 None None None 116622088 Common - TonB-dependent receptor, plug Acid_2975 24 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116622952 Common - histidinol-phosphate aminotransferase Acid_3854 237 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 116622818 Nonpathogen - hypothetical protein Acid_3718 1 None None None 116624762 Common - NADH-ubiquinone/plastoquinone oxidoreductase, chain 6 Acid_5686 161 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 116622445 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Acid_3343 100 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116624258 Common - PAS/PAC sensor hybrid histidine kinase Acid_5176 220 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116626118 Common - NAD-dependent epimerase/dehydratase Acid_7076 64 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116624194 Common - ribosomal protein L29 Acid_5110 68 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 116620502 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_1380 42 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 116621391 Nonpathogen - hypothetical protein Acid_2272 1 None None None 116622812 Nonpathogen - hypothetical protein Acid_3712 1 None None None 116624903 Nonpathogen - hypothetical protein Acid_5829 1 None None None 116623649 Common - efflux transporter, RND family, MFP subunit Acid_4561 158 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 116624560 Common - efflux transporter, RND family, MFP subunit Acid_5484 167 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116621871 Nonpathogen - hypothetical protein Acid_2754 2 None None None 116620854 Common - Dimethylargininase Acid_1735 26 COG1834 COG1834, N-Dimethylarginine dimethylaminohydrolase Amino acid transport and metabolism 116622014 Nonpathogen - hypothetical protein Acid_2899 5 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 116623178 Common - hypothetical protein Acid_4085 8 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 116622246 Common - amino acid aldolase or racemase-like protein Acid_3139 55 COG3616 COG3616, Predicted amino acid aldolase or racemase Amino acid transport and metabolism 116624889 Common - carbonic anhydrase Acid_5813 155 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 116621706 Nonpathogen - hypothetical protein Acid_2588 1 None None None 116621557 Common - beta-lactamase domain protein Acid_2439 64 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 116619219 Common - K+-transporting ATPase, B subunit Acid_0074 232 COG2216 KdpB, High-affinity K+ transport system, ATPase chain B Inorganic ion transport and metabolism 116619434 Nonpathogen - Endoribonuclease L-PSP Acid_0293 1 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 116620001 Common - serine/threonine protein kinase Acid_0873 164 COG5616 COG5616, Predicted integral membrane protein Function unknown 116624124 Nonpathogen - hypothetical protein Acid_5040 3 None None None 116626962 Nonpathogen - hypothetical protein Acid_7939 1 None None None 116624827 Common - hypothetical protein Acid_5751 18 None None None 116626442 Nonpathogen - hypothetical protein Acid_7404 1 None None None 116620953 Common - lipolytic enzyme, G-D-S-L family Acid_1834 109 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116626237 Common - short-chain dehydrogenase/reductase SDR Acid_7197 237 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 116620146 Common - NAD-dependent epimerase/dehydratase Acid_1019 221 COG1089 Gmd, GDP-D-mannose dehydratase Cell envelope biogenesis, outer membrane 116621583 Nonpathogen - hypothetical protein Acid_2465 2 None None None 116620408 Common - (p)ppGpp synthetase I, SpoT/RelA Acid_1285 207 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 116621070 Common - glycosyl hydrolase, BNR repeat Acid_1951 40 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116626873 Common - Tetratricopeptide TPR_2 repeat protein Acid_7848 29 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116623148 Common - glycoside hydrolase family 2, sugar binding Acid_4054 71 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 116625364 Common - dTDP-4-dehydrorhamnose reductase Acid_6309 176 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 116619697 Nonpathogen - hypothetical protein Acid_0562 1 COG4641 COG4641, Uncharacterized protein conserved in bacteria Function unknown 116620600 Common - transcriptional regulator, LacI family Acid_1479 126 COG1609 PurR, Transcriptional regulators Transcription 116626492 Common - hypothetical protein Acid_7455 7 None None None 116619507 Common - peptidase M28 Acid_0366 52 COG2234 Iap, Predicted aminopeptidases General function prediction only 116622630 Common - shikimate 5-dehydrogenase Acid_3529 224 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 116623794 Nonpathogen - hypothetical protein Acid_4706 1 None None None 116625732 Common - cytochrome bd ubiquinol oxidase, subunit I Acid_6681 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 116625955 Nonpathogen - hypothetical protein Acid_6913 7 None None None 116624814 Nonpathogen - putative transmembrane anti-sigma factor Acid_5738 2 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 116626090 Common - 3-oxoacyl-(acyl-carrier-protein) synthase III Acid_7048 223 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 116621401 Common - Redoxin domain protein Acid_2283 166 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116626935 Common - transcriptional regulator, PadR-like family Acid_7912 35 COG1695 COG1695, Predicted transcriptional regulators Transcription 116621217 Nonpathogen - protein of unknown function DUF1552 Acid_2098 6 None None None 116624370 Common - Methyltransferase type 11 Acid_5291 147 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116621914 Common - D-alanine--D-alanine ligase Acid_2799 212 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 116622342 Common - Quinoprotein glucose dehydrogenase Acid_3236 58 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116619598 Common - OsmC family protein Acid_0459 31 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 116620362 Common - serine phosphatase Acid_1239 99 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 116623910 Common - Lytic transglycosylase, catalytic Acid_4822 114 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 116625935 Common - protein of unknown function LppY and LpqO Acid_6893 16 None None None 116619725 Nonpathogen - hypothetical protein Acid_0590 10 None None None 116619875 Nonpathogen - hypothetical protein Acid_0747 3 None None None 116626697 Common - glycosyl hydrolase, BNR repeat-containing protein Acid_7669 9 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116619176 Common - protein of unknown function DUF323 Acid_0031 95 COG1262 COG1262, Uncharacterized conserved protein Function unknown 116624365 Nonpathogen - hypothetical protein Acid_5286 1 None None None 116619624 Common - response regulator receiver protein Acid_0485 202 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116623369 Common - peptidase M28 Acid_4278 62 COG2234 Iap, Predicted aminopeptidases General function prediction only 116623247 Common - protein of unknown function DUF214 Acid_4154 89 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116625213 Common - hypothetical protein Acid_6158 18 None None None 116626234 Common - methionine aminopeptidase, type I Acid_7194 243 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 116619253 Common - NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Acid_0109 163 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 116621892 Common - phage integrase family protein Acid_2776 200 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116626260 Common - cytochrome C family protein Acid_7220 26 None None None 116623092 Nonpathogen - hypothetical protein Acid_3996 1 None None None 116624911 Common - DEAD/H associated domain protein Acid_5837 212 COG1201 Lhr, Lhr-like helicases General function prediction only 116622399 Nonpathogen - hypothetical protein Acid_3293 1 COG2318 DinB, Uncharacterized protein conserved in bacteria Function unknown 116620831 Common - hypothetical protein Acid_1712 5 None None None 116625111 Nonpathogen - hypothetical protein Acid_6047 1 None None None 116622924 Nonpathogen - hypothetical protein Acid_3826 3 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116621001 Nonpathogen - ABC-2 type transporter Acid_1882 1 None None None 116624037 Common - protein of unknown function DUF214 Acid_4951 162 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116625659 Common - (2Fe-2S)-binding domain protein Acid_6608 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 116620812 Common - UvrD/REP helicase Acid_1693 229 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 116619615 Common - ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp Acid_0476 47 COG0439 AccC, Biotin carboxylase Lipid metabolism 116625519 Common - Inosine/uridine-preferring nucleoside hydrolase Acid_6466 86 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 116625502 Nonpathogen - small multidrug resistance protein Acid_6449 8 COG2510 COG2510, Predicted membrane protein Function unknown 116624061 Nonpathogen - hypothetical protein Acid_4975 13 None None None 116619297 Common - polymorphic membrane protein Acid_0153 26 None None None 116626245 Common - Glycine--tRNA ligase Acid_7205 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 116623007 Nonpathogen - hypothetical protein Acid_3911 1 None None None 116625089 Nonpathogen - hypothetical protein Acid_6023 1 None None None 116623689 Common - PfkB domain protein Acid_4601 84 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 116623487 Common - GCN5-related N-acetyltransferase Acid_4397 9 COG0456 RimI, Acetyltransferases General function prediction only 116619241 Nonpathogen - peptidase M56, BlaR1 Acid_0096 7 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 116620101 Common - protein of unknown function DUF1549 Acid_0974 6 None None None 116622768 Nonpathogen - hypothetical protein Acid_3667 5 None None None 116624200 Common - Ribosomal protein L25/L23 Acid_5116 215 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 116622910 Common - cell shape determining protein, MreB/Mrl family Acid_3811 208 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 116620983 Nonpathogen - hypothetical protein Acid_1864 2 None None None 116625017 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Acid_5947 5 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116620466 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Acid_1344 36 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 116621694 Common - Tetratricopeptide TPR_2 repeat protein Acid_2576 44 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116619741 Common - dihydroxy-acid dehydratase Acid_0606 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 116621740 Common - drug resistance transporter, EmrB/QacA subfamily Acid_2622 192 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116622268 Common - Stearoyl-CoA 9-desaturase Acid_3162 70 COG1398 OLE1, Fatty-acid desaturase Lipid metabolism 116624252 Common - glycosyl transferase, family 2 Acid_5170 104 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116626540 Common - hypothetical protein Acid_7503 10 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 116619272 Common - hypoxanthine phosphoribosyltransferase Acid_0128 151 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 116625159 Common - transposase Acid_6101 10 None None None 116621161 Common - response regulator receiver protein Acid_2042 188 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116619365 Common - ImcF domain protein Acid_0223 43 COG3523 IcmF, Uncharacterized protein conserved in bacteria Function unknown 116620462 Common - alkylhydroperoxidase like protein, AhpD family Acid_1340 38 COG2128 COG2128, Uncharacterized conserved protein Function unknown 116623354 Common - von Willebrand factor, type A Acid_4263 15 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 116621269 Common - Integrase, catalytic region Acid_2150 78 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 116626092 Nonpathogen - hypothetical protein Acid_7050 1 None None None 116625131 Nonpathogen - Pyrrolo-quinoline quinone Acid_6068 1 COG1520 COG1520, FOG: WD40-like repeat Function unknown 116620184 Nonpathogen - hypothetical protein Acid_1057 6 None None None 116622434 Common - Methionine synthase, vitamin-B12 independent Acid_3332 55 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 116621262 Nonpathogen - hypothetical protein Acid_2143 3 None None None 116625299 Common - transcriptional regulator, AraC family Acid_6244 138 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 116619193 Nonpathogen - Fimbrial assembly family protein Acid_0048 1 None None None 116620843 Common - protein of unknown function DUF214 Acid_1724 165 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622505 Nonpathogen - hypothetical protein Acid_3403 1 None None None 116626926 Nonpathogen - hypothetical protein Acid_7903 2 None None None 116619817 Common - Tetratricopeptide TPR_4 Acid_0687 86 COG5616 COG5616, Predicted integral membrane protein Function unknown 116621489 Common - high-affinity nickel-transporter Acid_2371 28 COG2215 COG2215, ABC-type uncharacterized transport system, permease component General function prediction only 116622114 Nonpathogen - hypothetical protein Acid_3002 1 COG5373 COG5373, Predicted membrane protein Function unknown 116620950 Common - peptidase M28 Acid_1831 38 COG2234 Iap, Predicted aminopeptidases General function prediction only 116621602 Nonpathogen - hypothetical protein Acid_2484 1 None None None 116622627 Common - transcriptional regulator, PadR-like family Acid_3526 34 COG1695 COG1695, Predicted transcriptional regulators Transcription 116625154 Nonpathogen - hypothetical protein Acid_6094 1 None None None 116619152 Common - TPR repeat protein Acid_0007 26 None None None 116623396 Common - conserved hypothetical protein, transmembrane prediction Acid_4305 8 None None None 116624296 Nonpathogen - DinB family protein Acid_5214 2 COG2318 DinB, Uncharacterized protein conserved in bacteria Function unknown 116626478 Common - glycosyl transferase, family 2 Acid_7441 132 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 116623460 Common - hypothetical protein Acid_4370 21 None None None 116625137 Common - short-chain dehydrogenase/reductase SDR Acid_6074 3 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116622794 Common - Peptidase S7, flavivirus helicase (NS3) Acid_3694 18 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 116626885 Nonpathogen - hypothetical protein Acid_7861 8 COG5343 COG5343, Uncharacterized protein conserved in bacteria Function unknown 116626539 Nonpathogen - hypothetical protein Acid_7502 1 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 116620323 Nonpathogen - hypothetical protein Acid_1200 1 None None None 116622832 Nonpathogen - hypothetical protein Acid_3732 1 COG4371 COG4371, Predicted membrane protein Function unknown 116625776 Common - cytochrome C family protein Acid_6726 28 None None None 116624511 Common - molybdate ABC transporter, inner membrane subunit Acid_5435 223 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 116625010 Common - serine/threonine protein kinase Acid_5940 208 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116625174 Common - TonB-dependent receptor Acid_6118 65 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116619206 Common - Allophanate hydrolase subunit 1 Acid_0061 109 COG2049 DUR1, Allophanate hydrolase subunit 1 Amino acid transport and metabolism 116622194 Common - Beta-N-acetylhexosaminidase Acid_3086 58 COG3525 Chb, N-acetyl-beta-hexosaminidase Carbohydrate transport and metabolism 116625297 Common - transcriptional regulator, PadR-like family Acid_6242 35 COG1695 COG1695, Predicted transcriptional regulators Transcription 116622732 Common - Uncharacterised conserved protein UCP016719 Acid_3631 162 COG3876 COG3876, Uncharacterized protein conserved in bacteria Function unknown 116623832 Common - outer membrane chaperone Skp (OmpH) Acid_4744 12 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 116624433 Nonpathogen - hypothetical protein Acid_5355 3 None None None 116625007 Common - protein of unknown function DUF336 Acid_5937 65 COG3193 GlcG, Uncharacterized protein, possibly involved in utilization of glycolate and propanediol General function prediction only 116626599 Common - transcriptional regulator, PadR-like family Acid_7562 44 COG1695 COG1695, Predicted transcriptional regulators Transcription 116624097 Common - glutaminyl-tRNA synthetase Acid_5012 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 116622760 Nonpathogen - hypothetical protein Acid_3659 1 None None None 116626730 Common - cysteine desulfurases, SufS subfamily Acid_7702 238 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 116620313 Common - phosphoesterase, PA-phosphatase related Acid_1190 113 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 116621482 Common - efflux transporter, RND family, MFP subunit Acid_2364 167 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116621692 Common - cold-shock DNA-binding domain protein Acid_2574 64 COG1278 CspC, Cold shock proteins Transcription 116623931 Nonpathogen - hypothetical protein Acid_4843 2 None None None 116620157 Common - cyclic nucleotide-regulated FAD-dependent pyridine nucleotide-disulphide oxidoreductase Acid_1030 245 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 116626433 Common - hypothetical protein Acid_7395 140 COG1660 COG1660, Predicted P-loop-containing kinase General function prediction only 116622581 Nonpathogen - hypothetical protein Acid_3479 1 None None None 116624487 Common - Stearoyl-CoA 9-desaturase Acid_5409 70 COG1398 OLE1, Fatty-acid desaturase Lipid metabolism 116625507 Common - efflux transporter, RND family, MFP subunit Acid_6454 169 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 116620575 Common - DSBA oxidoreductase Acid_1454 96 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 116625542 Common - chromosome segregation and condensation protein ScpA Acid_6489 147 COG1354 COG1354, Uncharacterized conserved protein Function unknown 116626123 Nonpathogen - hypothetical protein Acid_7081 1 None None None 116620345 Common - protein of unknown function DUF1684 Acid_1222 26 COG3358 COG3358, Uncharacterized conserved protein Function unknown 116622883 Common - endonuclease III Acid_3784 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 116626025 Common - aspartate-semialdehyde dehydrogenase Acid_6983 199 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 116623574 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Acid_4484 104 COG0388 COG0388, Predicted amidohydrolase General function prediction only 116626004 Common - redox-sensing transcriptional repressor Rex Acid_6962 56 COG2344 COG2344, AT-rich DNA-binding protein General function prediction only 116626288 Common - oxidoreductase, molybdopterin binding Acid_7248 85 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 116621732 Common - hypothetical protein Acid_2614 12 None None None 116624390 Nonpathogen - hypothetical protein Acid_5311 2 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 116625331 Nonpathogen - hypothetical protein Acid_6276 1 None None None 116625723 Common - domain of unknown function DUF1731 Acid_6672 112 COG1090 COG1090, Predicted nucleoside-diphosphate sugar epimerase General function prediction only 116620510 Common - Tetratricopeptide TPR_2 repeat protein Acid_1388 119 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116625528 Nonpathogen - hypothetical protein Acid_6475 1 None None None 116625545 Common - CoA-binding domain protein Acid_6492 141 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 116626832 Common - globin Acid_7805 26 COG2346 COG2346, Truncated hemoglobins General function prediction only 116623220 Common - alpha/beta hydrolase fold Acid_4127 70 COG0429 COG0429, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 116623117 Common - transcriptional regulator, PadR-like family Acid_4023 40 COG1695 COG1695, Predicted transcriptional regulators Transcription 116625903 Common - Tetratricopeptide TPR_2 repeat protein Acid_6859 37 COG4995 COG4995, Uncharacterized protein conserved in bacteria Function unknown 116623331 Nonpathogen - hypothetical protein Acid_4240 1 None None None 116624130 Common - conserved hypothetical protein, transmembrane prediction Acid_5046 8 None None None 116619577 Common - cyclic nucleotide-binding protein Acid_0438 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116625952 Common - cytochrome c, class I Acid_6910 23 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 116624261 Common - protein of unknown function DUF150 Acid_5179 162 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 116620214 Common - single-stranded nucleic acid binding R3H domain protein Acid_1089 38 COG1847 Jag, Predicted RNA-binding protein General function prediction only 116625667 Common - hypothetical protein Acid_6616 2 None None None 116623426 Common - phosphoesterase, PA-phosphatase related Acid_4335 76 None None None 116621835 Nonpathogen - transcriptional regulator, XRE family Acid_2717 2 None None None 116621024 Common - ATP-dependent nuclease subunit B-like protein Acid_1905 33 COG3857 AddB, ATP-dependent nuclease, subunit B DNA replication, recombination, and repair 116626213 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_7173 12 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116623553 Common - putative GAF sensor protein Acid_4463 135 COG3605 PtsP, Signal transduction protein containing GAF and PtsI domains Signal transduction mechanisms 116623188 Common - hypothetical protein Acid_4095 7 None None None 116621331 Common - putative lipoprotein Acid_2212 12 None None None 116624908 Common - aldo/keto reductase Acid_5834 203 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116626657 Common - Integrase, catalytic region Acid_7626 47 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 116626141 Common - heat shock protein Hsp20 Acid_7099 148 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 116620804 Nonpathogen - hypothetical protein Acid_1685 1 None None None 116622359 Nonpathogen - hypothetical protein Acid_3253 1 None None None 116624751 Common - Radical SAM domain protein Acid_5675 150 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116625438 Common - lipopolysaccharide heptosyltransferase I Acid_6383 97 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 116619185 Common - acyl-CoA dehydrogenase domain protein Acid_0040 151 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 116619432 Common - transcriptional regulator, GntR family Acid_0291 210 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 116623274 Nonpathogen - hypothetical protein Acid_4181 1 None None None 116621950 Nonpathogen - hypothetical protein Acid_2835 2 None None None 116622948 Common - imidazoleglycerol phosphate synthase, cyclase subunit Acid_3850 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 116625392 Common - GTP-binding protein LepA Acid_6337 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 116619606 Common - glycosyl transferase, family 2 Acid_0467 144 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116619308 Common - signal transduction histidine kinase, nitrogen specific, NtrB Acid_0165 221 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 116625110 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_6046 20 None None None 116619473 Common - MotA/TolQ/ExbB proton channel Acid_0332 99 COG1291 MotA, Flagellar motor component Cell motility and secretion 116622000 Common - multi-sensor signal transduction histidine kinase Acid_2885 224 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116623069 Nonpathogen - hypothetical protein Acid_3973 2 None None None 116624856 Common - serine/threonine protein kinase Acid_5780 154 COG3899 COG3899, Predicted ATPase General function prediction only 116621869 Common - prevent-host-death family protein Acid_2752 13 COG4118 Phd, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 116621522 Common - metallophosphoesterase Acid_2404 28 COG1409 Icc, Predicted phosphohydrolases General function prediction only 116626313 Common - putative mannose-6-phosphate isomerase Acid_7273 49 COG1482 ManA, Phosphomannose isomerase Carbohydrate transport and metabolism 116622688 Common - GCN5-related N-acetyltransferase Acid_3587 119 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 116626359 Common - S-adenosyl-methyltransferase MraW Acid_7319 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 116624151 Nonpathogen - hypothetical protein Acid_5067 1 None None None 116624716 Common - response regulator receiver protein Acid_5640 218 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 116626177 Common - 3-hydroxyisobutyrate dehydrogenase Acid_7137 173 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 116625916 Nonpathogen - hypothetical protein Acid_6873 1 None None None 116619952 Nonpathogen - hypothetical protein Acid_0824 1 None None None 116621841 Common - conserved hypothetical protein, transmembrane prediction Acid_2723 7 None None None 116622717 Common - aminotransferase, class I and II Acid_3616 241 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 116619673 Common - DNA-3-methyladenine glycosylase I Acid_0536 132 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 116621955 Common - hypothetical protein Acid_2840 23 None None None 116624772 Common - 3-hydroxyacyl-CoA dehydrogenase Acid_5696 161 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 116622444 Common - purine nucleoside permease Acid_3342 11 COG5042 NUP, Purine nucleoside permease Nucleotide transport and metabolism 116619373 Common - Uncharacterised conserved protein UCP028301 Acid_0231 50 COG3516 COG3516, Uncharacterized protein conserved in bacteria Function unknown 116620259 Common - transcriptional regulator, PadR-like family Acid_1136 55 COG1695 COG1695, Predicted transcriptional regulators Transcription 116620144 Common - peptidase U62, modulator of DNA gyrase Acid_1017 160 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 116619514 Nonpathogen - hypothetical protein Acid_0373 1 None None None 116626619 Common - cytochrome c oxidase, subunit III Acid_7582 152 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 116619216 Common - two component transcriptional regulator, winged helix family Acid_0071 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116626933 Common - outer membrane efflux protein Acid_7910 115 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116621040 Common - signal transduction histidine kinase, nitrogen specific, NtrB Acid_1921 221 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 116622668 Common - peptidase M23B Acid_3567 190 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 116626726 Common - protein of unknown function DUF433 Acid_7698 24 COG2442 COG2442, Uncharacterized conserved protein Function unknown 116625982 Common - glycosyl transferase, group 1 Acid_6940 35 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116623019 Common - hypothetical protein Acid_3923 56 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116624004 Common - TonB-dependent receptor, plug Acid_4916 23 None None None 116625730 Common - putative TIM-barrel protein, nifR3 family Acid_6679 212 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 116623377 Common - putative signal transduction protein with Nacht domain Acid_4286 17 COG5635 COG5635, Predicted NTPase (NACHT family) Signal transduction mechanisms 116621045 Common - PfkB domain protein Acid_1926 174 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 116621436 Nonpathogen - hypothetical protein Acid_2318 1 None None None 116623228 Common - hypothetical protein Acid_4135 2 None None None 116623614 Common - Protein-disulfide isomerase-like protein Acid_4524 53 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 116620587 Nonpathogen - hypothetical protein Acid_1466 1 None None None 116626798 Common - Pectinesterase Acid_7771 19 COG4677 PemB, Pectin methylesterase Carbohydrate transport and metabolism 116624951 Common - TIR protein Acid_5880 9 None None None 116624077 Nonpathogen - hypothetical protein Acid_4991 2 None None None 116625061 Common - ABC-2 type transporter Acid_5991 167 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 116624567 Common - beta-lactamase domain protein Acid_5491 49 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 116619973 Nonpathogen - PBS lyase HEAT domain protein repeat-containing protein Acid_0845 2 None None None 116619918 Nonpathogen - hypothetical protein Acid_0790 1 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 116626685 Common - hypothetical protein Acid_7657 3 None None None 116623749 Nonpathogen - hypothetical protein Acid_4661 1 None None None 116619746 Common - glycosyl transferase, family 2 Acid_0612 52 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116620110 Common - Isoprenylcysteine carboxyl methyltransferase Acid_0983 43 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 116625308 Common - hypothetical protein Acid_6253 11 None None None 116619502 Common - allantoate amidohydrolase Acid_0361 85 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116626252 Nonpathogen - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_7212 2 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 116619792 Nonpathogen - hypothetical protein Acid_0662 2 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 116620284 Common - GTP-binding protein, HSR1-related Acid_1161 210 COG2262 HflX, GTPases General function prediction only 116625082 Nonpathogen - hypothetical protein Acid_6014 1 None None None 116621739 Common - conserved repeat domain Acid_2621 27 None None None 116621609 Common - transcriptional regulator, PadR-like family Acid_2491 42 COG1695 COG1695, Predicted transcriptional regulators Transcription 116626308 Common - acylphosphatase Acid_7268 124 COG1254 AcyP, Acylphosphatases Energy production and conversion 116625080 Nonpathogen - hypothetical protein Acid_6011 1 None None None 116623259 Common - histidinol-phosphate aminotransferase Acid_4166 240 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 116619344 Nonpathogen - hypothetical protein Acid_0201 1 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116621570 Common - Transketolase, central region Acid_2452 213 COG3958 COG3958, Transketolase, C-terminal subunit Carbohydrate transport and metabolism 116622321 Common - putative esterase Acid_3215 16 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 116623941 Nonpathogen - hypothetical protein Acid_4853 1 None None None 116624845 Nonpathogen - hypothetical protein Acid_5769 1 None None None 116625162 Nonpathogen - hypothetical protein Acid_6105 5 COG3733 TynA, Cu2+-containing amine oxidase Secondary metabolites biosynthesis, transport, and catabolism 116623296 Common - glycine cleavage H-protein Acid_4203 163 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 116625259 Common - protein of unknown function DUF1009 Acid_6204 45 COG3494 COG3494, Uncharacterized protein conserved in bacteria Function unknown 116620125 Common - major facilitator superfamily MFS_1 Acid_0998 145 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116621781 Common - transposase IS116/IS110/IS902 family protein Acid_2663 87 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116625453 Nonpathogen - HNH endonuclease Acid_6398 1 None None None 116623431 Common - Citrate transporter Acid_4340 171 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 116619827 Common - amidohydrolase 2 Acid_0697 53 COG3618 COG3618, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 116626969 Nonpathogen - hypothetical protein Acid_7946 1 None None None 116626455 Nonpathogen - hypothetical protein Acid_7417 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116622420 Common - SMP-30/Gluconolaconase/LRE domain protein Acid_3317 6 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116621989 Nonpathogen - conserved hypothetical protein, transmembrane prediction Acid_2874 4 None None None 116622307 Common - Sialate O-acetylesterase Acid_3201 15 None None None 116621086 Common - hypothetical protein Acid_1967 37 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 116620380 Nonpathogen - Tetratricopeptide TPR_4 Acid_1257 7 None None None 116621417 Nonpathogen - hypothetical protein Acid_2299 2 None None None 116622197 Nonpathogen - hypothetical protein Acid_3089 1 None None None 116622887 Nonpathogen - hypothetical protein Acid_3788 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116624933 Nonpathogen - hypothetical protein Acid_5860 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116623909 Common - cytochrome oxidase assembly Acid_4821 13 COG1612 CtaA, Uncharacterized protein required for cytochrome oxidase assembly Posttranslational modification, protein turnover, chaperones 116620901 Common - hypothetical protein Acid_1782 7 None None None 116622067 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) Acid_2954 192 COG0281 SfcA, Malic enzyme Energy production and conversion 116619770 Nonpathogen - hypothetical protein Acid_0638 6 None None None 116624465 Nonpathogen - sulfatase Acid_5387 2 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116625169 Common - inner-membrane translocator Acid_6113 106 COG1079 COG1079, Uncharacterized ABC-type transport system, permease component General function prediction only 116625246 Nonpathogen - hypothetical protein Acid_6191 1 None None None 116620682 Common - Redoxin domain protein Acid_1562 176 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116621516 Common - hemerythrin-like metal-binding protein Acid_2398 44 COG2703 COG2703, Hemerythrin Inorganic ion transport and metabolism 116619899 Common - lipid-A-disaccharide synthase Acid_0771 139 COG0763 LpxB, Lipid A disaccharide synthetase Cell envelope biogenesis, outer membrane 116624483 Common - hypothetical protein Acid_5405 30 COG4907 COG4907, Predicted membrane protein Function unknown 116622218 Common - TonB-dependent receptor Acid_3111 24 None None None 116622605 Common - transcriptional regulator, BadM/Rrf2 family Acid_3503 171 COG1959 COG1959, Predicted transcriptional regulator Transcription 116626869 Common - ATP dependent DNA ligase Acid_7844 105 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 116622404 Nonpathogen - hypothetical protein Acid_3298 1 None None None 116620646 Common - hypothetical protein Acid_1525 12 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 116620785 Common - outer membrane efflux protein Acid_1666 101 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116620433 Common - transcriptional regulator, Fis family Acid_1311 131 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 116622429 Nonpathogen - hypothetical protein Acid_3327 1 None None None 116619445 Common - glycosyl transferase, group 1 Acid_0304 113 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116620426 Common - serine/threonine protein kinase Acid_1303 157 COG3899 COG3899, Predicted ATPase General function prediction only 116621204 Common - Carboxylesterase, type B Acid_2085 70 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 116626761 Common - glutamine cyclotransferase Acid_7734 22 COG3823 COG3823, Glutamine cyclotransferase Posttranslational modification, protein turnover, chaperones 116619684 Nonpathogen - hypothetical protein Acid_0549 5 None None None 116623292 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_4199 169 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116622480 Common - succinyl-CoA synthetase, beta subunit Acid_3378 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 116620188 Common - general secretion pathway protein G Acid_1061 13 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 116619314 Nonpathogen - protein of unknown function DUF362 Acid_0171 8 COG2006 COG2006, Uncharacterized conserved protein Function unknown 116621151 Nonpathogen - protein of unknown function DUF1552 Acid_2032 6 None None None 116620683 Common - 6-pyruvoyl tetrahydropterin synthase and hypothetical protein Acid_1563 113 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 116625219 Common - Ig family protein Acid_6164 104 None None None 116619350 Nonpathogen - hypothetical protein Acid_0208 1 None None None 116622364 Nonpathogen - hypothetical protein Acid_3258 3 None None None 116626592 Common - putative circadian clock protein, KaiC Acid_7555 118 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 116621776 Common - neuraminidase (sialidase)-like protein Acid_2658 27 COG4692 COG4692, Predicted neuraminidase (sialidase) Carbohydrate transport and metabolism 116625745 Common - response regulator receiver protein Acid_6695 208 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116626170 Nonpathogen - hypothetical protein Acid_7130 1 None None None 116621812 Common - peptidase M56, BlaR1 Acid_2694 30 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 116619236 Common - hypothetical protein Acid_0091 3 None None None 116621589 Common - serine/threonine protein kinase Acid_2471 152 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116623476 Nonpathogen - hypothetical protein Acid_4386 7 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 116621504 Common - hypothetical protein Acid_2386 10 None None None 116619454 Common - Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) Acid_0313 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 116624289 Common - imidazolonepropionase Acid_5207 106 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116623878 Common - outer membrane chaperone Skp (OmpH) Acid_4790 25 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 116623027 Common - hypothetical protein Acid_3931 12 None None None 116626905 Common - hypothetical protein Acid_7882 37 COG5587 COG5587, Uncharacterized conserved protein Function unknown 116620395 Common - two component transcriptional regulator, LuxR family Acid_1272 210 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116626037 Common - dihydroorotate dehydrogenase 2 Acid_6995 88 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 116626828 Common - hypothetical protein Acid_7801 39 COG4430 COG4430, Uncharacterized protein conserved in bacteria Function unknown 116622661 Common - metallophosphoesterase Acid_3560 32 COG1409 Icc, Predicted phosphohydrolases General function prediction only 116622697 Nonpathogen - hypothetical protein Acid_3596 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116620332 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_1209 15 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116624058 Nonpathogen - hypothetical protein Acid_4972 1 None None None 116626035 Common - glycerophosphoryl diester phosphodiesterase Acid_6993 164 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 116626809 Nonpathogen - hypothetical protein Acid_7782 1 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 116620448 Nonpathogen - hypothetical protein Acid_1326 1 None None None 116620707 Common - twitching motility protein Acid_1587 164 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 116622042 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_2927 157 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 116620630 Nonpathogen - hypothetical protein Acid_1509 3 None None None 116622994 Nonpathogen - hypothetical protein Acid_3898 2 None None None 116624595 Common - efflux transporter, RND family, MFP subunit Acid_5519 166 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 116622987 Common - LmbE family protein Acid_3890 42 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 116621454 Common - short-chain dehydrogenase/reductase SDR Acid_2336 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116624112 Common - sugar transporter Acid_5028 163 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116622780 Nonpathogen - hypothetical protein Acid_3679 7 None None None 116622556 Common - Tetratricopeptide TPR_4 Acid_3454 43 COG4995 COG4995, Uncharacterized protein conserved in bacteria Function unknown 116620019 Common - hydrolase of the HD superfamily (permuted catalytic motifs)-like protein Acid_0891 20 COG1353 COG1353, Predicted hydrolase of the HD superfamily (permuted catalytic motifs) General function prediction only 116622921 Common - Ethanolamine ammonia-lyase Acid_3823 52 COG4302 EutC, Ethanolamine ammonia-lyase, small subunit Amino acid transport and metabolism 116621422 Nonpathogen - hypothetical protein Acid_2304 1 None None None 116625338 Common - integral membrane sensor signal transduction histidine kinase Acid_6283 220 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 116624727 Common - Polysulphide reductase, NrfD Acid_5651 24 COG4881 COG4881, Predicted membrane protein Function unknown 116626126 Common - PfkB domain protein Acid_7084 63 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 116622551 Common - Outer membrane protein/protective antigen OMA87-like protein Acid_3449 15 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 116623345 Common - type I phosphodiesterase/nucleotide pyrophosphatase Acid_4254 18 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 116626056 Nonpathogen - hypothetical protein Acid_7014 1 None None None 116621755 Nonpathogen - SMP-30/Gluconolaconase/LRE domain protein Acid_2637 11 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116626840 Common - hypothetical protein Acid_7813 4 None None None 116625768 Common - GHMP kinase Acid_6718 4 COG1577 ERG12, Mevalonate kinase Lipid metabolism 116621352 Common - Xylose isomerase domain protein TIM barrel Acid_2233 13 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116622858 Common - Endoribonuclease L-PSP Acid_3759 87 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 116619247 Common - drug resistance transporter, EmrB/QacA subfamily Acid_0103 223 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116622145 Common - Activator of Hsp90 ATPase 1 family protein Acid_3037 17 COG3832 COG3832, Uncharacterized conserved protein Function unknown 116621099 Common - glycosyltransferase, MGT family Acid_1980 66 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 116620696 Nonpathogen - hypothetical protein Acid_1576 1 None None None 116621979 Common - ROK family protein Acid_2864 166 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 116626489 Common - SAF domain Acid_7452 16 COG1261 FlgA, Flagellar basal body P-ring biosynthesis protein Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 116621513 Common - carbamoyl-phosphate synthase, large subunit Acid_2395 238 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 116626851 Common - ABC transporter related Acid_7824 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 116620302 Common - diguanylate cyclase Acid_1179 176 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 116626800 Common - glycoside hydrolase, family 28 Acid_7773 27 COG5434 PGU1, Endopygalactorunase Cell envelope biogenesis, outer membrane 116622620 Common - globin Acid_3519 89 COG2346 COG2346, Truncated hemoglobins General function prediction only 116624743 Common - TonB-dependent receptor, plug Acid_5667 24 None None None 116625597 Common - hypothetical protein Acid_6546 2 None None None 116625662 Common - serine/threonine protein kinase Acid_6611 145 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116621527 Nonpathogen - von Willebrand factor, type A Acid_2409 2 None None None 116621380 Common - carboxyl transferase Acid_2261 215 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 116622651 Common - Activator of Hsp90 ATPase 1 family protein Acid_3550 3 COG3832 COG3832, Uncharacterized conserved protein Function unknown 116623982 Common - protein of unknown function DUF442 Acid_4894 36 COG3453 COG3453, Uncharacterized protein conserved in bacteria Function unknown 116621034 Common - RNA binding S1 domain protein Acid_1915 226 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 116621013 Common - Erythromycin esterase Acid_1894 31 COG2312 COG2312, Erythromycin esterase homolog General function prediction only 116621833 Common - membrane-bound metal-dependent hydrolase Acid_2715 12 COG1988 COG1988, Predicted membrane-bound metal-dependent hydrolases General function prediction only 116626663 Nonpathogen - hypothetical protein Acid_7632 4 None None None 116620819 Common - DNA-cytosine methyltransferase Acid_1700 108 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 116625328 Nonpathogen - hypothetical protein Acid_6273 1 None None None 116619359 Common - glycogen debranching enzyme, putative Acid_0217 36 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 116620555 Common - homoserine O-acetyltransferase Acid_1433 133 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 116623704 Common - response regulator receiver modulated diguanylate cyclase Acid_4616 221 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 116623035 Common - cation diffusion facilitator family transporter Acid_3939 214 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 116623218 Common - protein of unknown function DUF214 Acid_4125 153 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620203 Common - hypothetical protein Acid_1076 4 None None None 116619556 Common - oxidoreductase domain protein Acid_0417 127 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116621876 Nonpathogen - hypothetical protein Acid_2759 2 None None None 116619883 Common - UBA/THIF-type NAD/FAD binding protein Acid_0755 226 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 116624686 Common - asparagine synthase (glutamine-hydrolyzing) Acid_5610 160 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 116625618 Common - peptidase U32 Acid_6567 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 116619651 Common - WD40 domain protein beta Propeller Acid_0512 148 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116626102 Common - acyl-CoA dehydrogenase domain protein Acid_7060 163 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 116624442 Nonpathogen - hypothetical protein Acid_5364 1 None None None 116620245 Common - Dipeptidyl aminopeptidases/acylaminoacyl-peptidase-like protein Acid_1122 5 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116621073 Common - amidohydrolase Acid_1954 171 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116624426 Nonpathogen - hypothetical protein Acid_5348 1 None None None 116626369 Common - Radical SAM domain protein Acid_7329 139 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116626756 Common - amine oxidase Acid_7729 26 COG1231 COG1231, Monoamine oxidase Amino acid transport and metabolism 116621121 Common - Tetratricopeptide TPR_2 repeat protein Acid_2002 58 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116625481 Common - Radical SAM domain protein Acid_6427 22 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116621591 Common - hypothetical protein Acid_2473 20 COG1359 COG1359, Uncharacterized conserved protein Function unknown 116624720 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_5644 146 COG1146 COG1146, Ferredoxin Energy production and conversion 116619481 Common - flagellar M-ring protein FliF Acid_0340 128 COG1766 FliF, Flagellar biosynthesis/type III secretory pathway lipoprotein Cell motility and secretion / Intracellular trafficking and secretion 116624073 Nonpathogen - hypothetical protein Acid_4987 3 None None None 116623638 Common - permease Acid_4550 12 None None None 116621569 Common - histidine kinase Acid_2451 121 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 116626671 Common - phage integrase family protein Acid_7640 191 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116623625 Common - serine/threonine protein kinase Acid_4535 166 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116623014 Nonpathogen - hypothetical protein Acid_3918 1 COG3258 COG3258, Cytochrome c Energy production and conversion 116619758 Common - IstB domain protein ATP-binding protein Acid_0624 87 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 116624404 Common - Xylose isomerase domain protein TIM barrel Acid_5326 9 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116623631 Nonpathogen - von Willebrand factor, type A Acid_4543 2 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 116623595 Common - protein of unknown function DUF1453 Acid_4505 6 COG4846 CcdC, Membrane protein involved in cytochrome C biogenesis Posttranslational modification, protein turnover, chaperones 116625899 Common - Cna B-type protein Acid_6854 24 None None None 116626641 Common - Cna B domain protein Acid_7606 23 None None None 116620210 Common - von Willebrand factor, type A Acid_1083 14 COG2425 COG2425, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 116620882 Common - peptidase S10, serine carboxypeptidase Acid_1763 37 COG2939 COG2939, Carboxypeptidase C (cathepsin A) Amino acid transport and metabolism 116626919 Common - cytochrome C family protein Acid_7896 28 None None None 116625892 Common - NHL repeat containing protein Acid_6846 135 COG3889 COG3889, Predicted solute binding protein General function prediction only 116620077 Common - hypothetical protein Acid_0949 9 None None None 116624581 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_5505 114 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116622155 Common - Aldose 1-epimerase Acid_3047 50 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 116620627 Nonpathogen - hypothetical protein Acid_1506 2 None None None 116623642 Nonpathogen - hypothetical protein Acid_4554 1 None None None 116624639 Common - hypothetical protein Acid_5563 47 COG5267 COG5267, Uncharacterized protein conserved in bacteria Function unknown 116619429 Common - protein tyrosine phosphatase Acid_0288 100 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 116626867 Common - Ku domain protein Acid_7842 63 COG1273 COG1273, Uncharacterized conserved protein Function unknown 116624533 Common - DNA-directed RNA polymerase, beta subunit Acid_5457 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 116625349 Common - undecaprenyl diphosphate synthase Acid_6294 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 116624478 Common - hypothetical protein Acid_5400 10 COG4373 COG4373, Mu-like prophage FluMu protein gp28 General function prediction only 116626183 Common - flagellar hook-associated protein FlgK Acid_7143 119 COG1256 FlgK, Flagellar hook-associated protein Cell motility and secretion 116622333 Common - hypothetical protein Acid_3227 23 None None None 116624522 Common - FAD dependent oxidoreductase Acid_5446 15 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 116621369 Common - glucose-1-phosphate cytidylyltransferase Acid_2250 176 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 116622721 Common - transcriptional regulator, PadR-like family Acid_3620 64 COG1695 COG1695, Predicted transcriptional regulators Transcription 116624337 Nonpathogen - hypothetical protein Acid_5255 2 None None None 116619488 Common - phage integrase family protein Acid_0347 231 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116624806 Common - transcriptional regulator, PadR-like family Acid_5730 41 COG1695 COG1695, Predicted transcriptional regulators Transcription 116626076 Common - hypothetical protein Acid_7034 29 COG2944 COG2944, Predicted transcriptional regulator Transcription 116620007 Common - sulfatase Acid_0879 91 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116625625 Common - ABC transporter related Acid_6574 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116623000 Common - major facilitator superfamily MFS_1 Acid_3904 148 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116625367 Common - Alcohol dehydrogenase, zinc-binding domain protein Acid_6312 183 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 116624645 Common - cobalamin synthesis protein, P47K Acid_5569 69 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 116624984 Common - hemerythrin-like metal-binding protein Acid_5914 50 COG2703 COG2703, Hemerythrin Inorganic ion transport and metabolism 116624661 Common - hypothetical protein Acid_5585 21 COG5473 COG5473, Predicted integral membrane protein Function unknown 116619835 Common - Alpha-galactosidase Acid_0705 15 COG3345 GalA, Alpha-galactosidase Carbohydrate transport and metabolism 116622041 Common - Rieske (2Fe-2S) domain protein Acid_2926 42 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 116625063 Nonpathogen - hypothetical protein Acid_5993 1 None None None 116622055 Nonpathogen - hypothetical protein Acid_2941 1 None None None 116622174 Common - hypothetical protein Acid_3066 23 None None None 116625575 Common - peptidase S9, prolyl oligopeptidase active site domain protein Acid_6523 194 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116622248 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_3141 148 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116622913 Common - serine/threonine protein kinase with TPR repeats Acid_3814 156 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116625792 Nonpathogen - hypothetical protein Acid_6742 1 None None None 116623081 Common - glycoside hydrolase, family 28 Acid_3985 25 COG5434 PGU1, Endopygalactorunase Cell envelope biogenesis, outer membrane 116621300 Common - signal transduction histidine kinase, LytS Acid_2181 108 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 116625460 Nonpathogen - hypothetical protein Acid_6405 2 None None None 116619498 Common - guanine deaminase Acid_0357 140 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 116622331 Common - transcriptional regulator domain protein Acid_3225 49 COG5616 COG5616, Predicted integral membrane protein Function unknown 116625372 Nonpathogen - hypothetical protein Acid_6317 1 None None None 116622904 Common - hypothetical protein Acid_3805 3 None None None 116623454 Common - protein of unknown function UPF0052 and CofD Acid_4363 95 COG0391 COG0391, Uncharacterized conserved protein Function unknown 116623514 Nonpathogen - hypothetical protein Acid_4424 1 None None None 116620539 Common - protein of unknown function DUF362 Acid_1417 38 COG2006 COG2006, Uncharacterized conserved protein Function unknown 116623090 Common - NADPH-dependent FMN reductase Acid_3994 109 COG0431 COG0431, Predicted flavoprotein General function prediction only 116625059 Common - ABC transporter related Acid_5989 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116620224 Common - two component transcriptional regulator, winged helix family Acid_1101 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116621889 Nonpathogen - hypothetical protein Acid_2772 1 None None None 116621090 Common - hypothetical protein Acid_1971 7 None None None 116623791 Common - amidohydrolase Acid_4703 97 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116621474 Common - glycosyl transferase, family 9 Acid_2356 95 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 116623143 Common - dihydrodipicolinate synthetase Acid_4049 206 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 116626530 Nonpathogen - hypothetical protein Acid_7493 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116624119 Nonpathogen - hypothetical protein Acid_5035 1 None None None 116625309 Common - hypothetical protein Acid_6254 24 COG4898 COG4898, Uncharacterized protein conserved in bacteria Function unknown 116621648 Common - hypothetical protein Acid_2530 6 None None None 116624978 Common - multi-sensor hybrid histidine kinase Acid_5908 224 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116623918 Common - hypothetical protein Acid_4830 86 None None None 116625488 Common - hypothetical protein Acid_6434 122 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 116620918 Common - phenazine biosynthesis protein PhzF family Acid_1799 121 COG0384 COG0384, Predicted epimerase, PhzC/PhzF homolog General function prediction only 116622178 Common - Pyrrolo-quinoline quinone Acid_3070 61 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116619987 Common - protein of unknown function DUF1501 Acid_0859 5 COG4102 COG4102, Uncharacterized protein conserved in bacteria Function unknown 116620450 Common - peptidase M16 domain protein Acid_1328 200 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 116625703 Common - response regulator receiver protein Acid_6652 50 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116620563 Common - metallophosphoesterase Acid_1441 13 None None None 116626773 Common - type II secretion system protein Acid_7746 84 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 116622514 Common - hypothetical protein Acid_3412 6 None None None 116619478 Common - flagellar basal-body rod protein FlgB Acid_0337 87 COG1815 FlgB, Flagellar basal body protein Cell motility and secretion 116626849 Nonpathogen - hypothetical protein Acid_7822 1 None None None 116619849 Common - FG-GAP repeat protein Acid_0721 62 None None None 116624457 Nonpathogen - hypothetical protein Acid_5379 3 None None None 116623472 Common - protoheme IX farnesyltransferase Acid_4382 170 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 116624518 Nonpathogen - hypothetical protein Acid_5442 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116625828 Common - transposase Acid_6781 38 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 116626690 Common - aminotransferase class-III Acid_7662 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 116619224 Common - ABC transporter related Acid_0079 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116623040 Common - 3-oxoacyl-(acyl-carrier-protein) reductase Acid_3944 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116625320 Common - serine/threonine protein kinase Acid_6265 163 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116619916 Nonpathogen - hypothetical protein Acid_0788 1 None None None 116624967 Nonpathogen - hypothetical protein Acid_5897 1 None None None 116622588 Common - Antibiotic biosynthesis monooxygenase Acid_3486 16 COG1359 COG1359, Uncharacterized conserved protein Function unknown 116620936 Common - TonB-dependent receptor Acid_1817 24 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116620964 Common - MazG family protein Acid_1845 158 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 116619924 Common - RNA polymerase, sigma 70 subunit, RpoD family Acid_0796 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 116620844 Common - protein of unknown function DUF214 Acid_1725 180 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116620949 Nonpathogen - hypothetical protein Acid_1830 1 None None None 116625248 Common - transcriptional regulator, PadR-like family Acid_6193 50 COG1695 COG1695, Predicted transcriptional regulators Transcription 116626811 Nonpathogen - hypothetical protein Acid_7784 2 COG3156 PulK, Type II secretory pathway, component PulK Intracellular trafficking and secretion 116620637 Nonpathogen - hypothetical protein Acid_1516 1 COG5617 COG5617, Predicted integral membrane protein Function unknown 116622207 Common - thiamine pyrophosphate enzyme TPP binding domain protein Acid_3099 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 116621741 Common - secretion protein HlyD family protein Acid_2623 119 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116625854 Nonpathogen - hypothetical protein Acid_6808 6 None None None 116620192 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Acid_1065 186 COG2876 AroA, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 116625813 Common - protein of unknown function DUF178 Acid_6764 33 COG1427 COG1427, Predicted periplasmic solute-binding protein General function prediction only 116623774 Nonpathogen - hypothetical protein Acid_4686 1 None None None 116625188 Common - Pyrrolo-quinoline quinone Acid_6133 63 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116626473 Common - Methyltransferase type 11 Acid_7436 202 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116625884 Common - hypothetical protein Acid_7950 35 None None None 116624960 Common - OmpA/MotB domain protein Acid_5889 117 COG1360 MotB, Flagellar motor protein Cell motility and secretion 116623303 Common - Alpha-L-fucosidase Acid_4210 32 COG3669 COG3669, Alpha-L-fucosidase Carbohydrate transport and metabolism 116620580 Common - NmrA family protein Acid_1459 116 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116623408 Common - LVIVD repeat protein Acid_4317 15 COG5276 COG5276, Uncharacterized conserved protein Function unknown 116621372 Nonpathogen - hypothetical protein Acid_2253 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116624824 Common - tryptophan synthase subunit beta Acid_5748 224 COG1350 COG1350, Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) General function prediction only 116623494 Common - hypothetical protein Acid_4404 26 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 116620027 Common - peptidase M56, BlaR1 Acid_0899 26 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 116619516 Nonpathogen - hypothetical protein Acid_7949 6 None None None 116620405 Common - Biopolymer transport protein ExbD/TolR Acid_1282 136 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 116620717 Common - protein of unknown function DUF500 Acid_1597 35 COG2930 COG2930, Uncharacterized conserved protein Function unknown 116620724 Common - integral membrane sensor signal transduction histidine kinase Acid_1604 154 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 116620833 Common - protein of unknown function UPF0150 Acid_1714 13 COG1598 COG1598, Uncharacterized conserved protein Function unknown 116624543 Common - 3-deoxy-7-phosphoheptulonate synthase Acid_5467 73 COG3200 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 116620998 Nonpathogen - hypothetical protein Acid_1879 1 None None None 116625636 Common - hypothetical protein Acid_6585 12 None None None 116622078 Common - protein of unknown function UPF0118 Acid_2965 178 COG0628 PerM, Predicted permease General function prediction only 116624084 Common - Aldose 1-epimerase Acid_4998 46 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 116622723 Nonpathogen - glycosyl transferase, family 39 Acid_3622 4 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116626293 Common - hypothetical protein Acid_7253 6 COG3915 COG3915, Uncharacterized protein conserved in bacteria Function unknown 116625409 Common - Queuosine biosynthesis protein Acid_6354 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 116620175 Common - hypothetical protein Acid_1048 28 COG4913 COG4913, Uncharacterized protein conserved in bacteria Function unknown 116625970 Common - hydrogenase assembly chaperone hypC/hupF Acid_6928 101 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 116623582 Nonpathogen - hypothetical protein Acid_4492 1 None None None 116621356 Common - sugar isomerase (SIS) Acid_2237 121 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 116622153 Nonpathogen - hypothetical protein Acid_3045 3 None None None 116624894 Common - response regulator receiver protein Acid_5818 58 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116619397 Common - CoA-binding domain protein Acid_0256 149 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 116620528 Common - two component transcriptional regulator, LuxR family Acid_1406 169 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116621343 Common - acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase Acid_2224 154 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116622424 Nonpathogen - hypothetical protein Acid_3321 1 None None None 116626310 Nonpathogen - hypothetical protein Acid_7270 1 None None None 116619330 Common - hypothetical protein Acid_0187 23 None None None 116623260 Common - 4-hydroxyphenylpyruvate dioxygenase Acid_4167 77 COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins Amino acid transport and metabolism / General function prediction only 116624311 Common - hypothetical protein Acid_5229 18 None None None 116620129 Common - Zn-dependent hydrolase Acid_1002 13 None None None 116622064 Nonpathogen - hypothetical protein Acid_2951 1 None None None 116621897 Nonpathogen - hypothetical protein Acid_2782 3 None None None 116624498 Common - response regulator receiver protein Acid_5422 211 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116620357 Common - transcriptional regulator, LacI family Acid_1234 126 COG1609 PurR, Transcriptional regulators Transcription 116624417 Common - ABC transporter related Acid_5339 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116625815 Nonpathogen - FG-GAP repeat protein Acid_6766 7 None None None 116619450 Common - transcriptional regulator, TraR/DksA family Acid_0309 73 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 116620172 Common - protein of unknown function DUF214 Acid_1045 157 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622983 Common - OsmC family protein Acid_3886 73 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 116621228 Common - hypothetical protein Acid_2109 23 None None None 116621682 Nonpathogen - hypothetical protein Acid_2564 2 None None None 116623269 Common - SEC-C motif domain protein Acid_4176 34 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 116624905 Nonpathogen - hypothetical protein Acid_5831 1 None None None 116622564 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Acid_3462 3 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 116622954 Common hisG ATP phosphoribosyltransferase Acid_3856 214 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 116620634 Nonpathogen - hypothetical protein Acid_1513 1 COG4485 COG4485, Predicted membrane protein Function unknown 116626422 Common - membrane bound O-acyl transferase, MBOAT family protein Acid_7384 86 COG1696 DltB, Predicted membrane protein involved in D-alanine export Cell envelope biogenesis, outer membrane 116624164 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_5080 14 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116624748 Nonpathogen - hypothetical protein Acid_5672 1 None None None 116622654 Nonpathogen - hypothetical protein Acid_3553 6 None None None 116623010 Nonpathogen - hypothetical protein Acid_3914 5 None None None 116623654 Common - Tetratricopeptide TPR_2 repeat protein Acid_4566 115 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 116626346 Nonpathogen - hypothetical protein Acid_7306 3 None None None 116619339 Common - Cna B-type protein Acid_0196 22 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116620092 Nonpathogen - Late embryogenesis abundant protein Acid_0964 2 COG4980 GvpP, Gas vesicle protein General function prediction only 116620105 Nonpathogen - hypothetical protein Acid_0978 1 None None None 116622633 Common - peptidase M14, carboxypeptidase A Acid_3532 23 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 116625568 Common - hypothetical protein Acid_6515 94 None None None 116619558 Common - Nucleotidyl transferase Acid_0419 190 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 116626136 Common - peptidyl-tRNA hydrolase Acid_7094 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 116622182 Nonpathogen - hypothetical protein Acid_3074 2 None None None 116623828 Nonpathogen - response regulator receiver protein Acid_4740 4 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116626388 Common - hypothetical protein Acid_7348 9 None None None 116621221 Common - alpha/beta hydrolase Acid_2102 21 COG0657 Aes, Esterase/lipase Lipid metabolism 116624817 Nonpathogen - hypothetical protein Acid_5741 5 None None None 116620729 Common - plasmid related protein Acid_1609 19 None None None 116624688 Nonpathogen - hypothetical protein Acid_5612 5 None None None 116622447 Common - Dimethylmenaquinone methyltransferase Acid_3345 73 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 116620264 Nonpathogen - hypothetical protein Acid_1141 1 None None None 116622685 Nonpathogen - hypothetical protein Acid_3584 1 None None None 116619384 Common - PAAR repeat-containing protein Acid_0242 25 COG4104 COG4104, Uncharacterized conserved protein Function unknown 116622893 Common - hypothetical protein Acid_3794 16 None None None 116623442 Common - major facilitator superfamily MFS_1 Acid_4351 60 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116621831 Common - protein of unknown function DUF214 Acid_2713 138 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116621407 Common - Quinoprotein glucose dehydrogenase Acid_2289 96 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116619622 Common - glycine cleavage system H protein Acid_0483 188 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 116623708 Common - hypothetical protein Acid_4620 3 None None None 116622543 Nonpathogen - phospholipase/Carboxylesterase Acid_3441 14 COG0400 COG0400, Predicted esterase General function prediction only 116625077 Common - protein of unknown function DUF1311 Acid_6008 20 COG3755 COG3755, Uncharacterized protein conserved in bacteria Function unknown 116626922 Common - CBS domain containing protein Acid_7899 106 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 116621970 Common - acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase Acid_2855 152 COG1043 LpxA, Acyl- acyl carrier protein 116623161 Common - pyruvate carboxyltransferase Acid_4067 214 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 116619711 Common - oxidoreductase domain protein Acid_0576 161 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116619526 Nonpathogen - hypothetical protein Acid_0385 1 None None None 116623540 Common - hypothetical protein Acid_4450 24 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116623863 Common - conserved repeat domain Acid_4775 16 None None None 116624757 Common - protein of unknown function DUF433 Acid_5681 20 COG2442 COG2442, Uncharacterized conserved protein Function unknown 116626378 Common - amidohydrolase Acid_7338 54 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116622238 Nonpathogen - putative secreted protein Acid_3131 7 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 116624714 Common - ABC transporter related Acid_5638 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116624333 Common - Colicin V production protein Acid_5251 65 COG1286 CvpA, Uncharacterized membrane protein, required for colicin V production General function prediction only 116626705 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_7677 13 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116620959 Common - beta-lactamase domain protein Acid_1840 98 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 116625495 Nonpathogen - Uncharacterized protein related to Endonuclease III Acid_6442 25 COG2231 COG2231, Uncharacterized protein related to Endonuclease III DNA replication, recombination, and repair 116621555 Nonpathogen - hypothetical protein Acid_2437 1 None None None 116623314 Common - riboflavin biosynthesis protein RibD Acid_4222 230 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 116620649 Nonpathogen - hypothetical protein Acid_1529 2 None None None 116619536 Common - transcriptional regulator, Fis family Acid_0395 45 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 116624679 Common - hypothetical protein Acid_5603 32 COG3911 COG3911, Predicted ATPase General function prediction only 116621969 Nonpathogen - hypothetical protein Acid_2854 1 None None None 116620088 Common - domain of unknown function DUF1731 Acid_0960 104 COG1090 COG1090, Predicted nucleoside-diphosphate sugar epimerase General function prediction only 116626601 Common - protein of unknown function DUF323 Acid_7564 112 COG1262 COG1262, Uncharacterized conserved protein Function unknown 116625184 Common - response regulator receiver protein Acid_6129 193 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116626804 Nonpathogen - hypothetical protein Acid_7777 1 None None None 116625314 Nonpathogen - hypothetical protein Acid_6259 3 None None None 116625464 Nonpathogen - hypothetical protein Acid_6409 1 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 116624935 Common - cytidylyltransferase Acid_5862 39 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 116623284 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_4191 22 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 116623126 Nonpathogen - hypothetical protein Acid_4032 1 None None None 116620559 Common - putative integral membrane protein Acid_1437 4 COG4975 GlcU, Putative glucose uptake permease Carbohydrate transport and metabolism 116625821 Common - Carboxylesterase, type B Acid_6772 59 COG2272 PnbA, Carboxylesterase type B Lipid metabolism 116619785 Common - methyltransferase FkbM family Acid_0655 3 None None None 116622344 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Acid_3238 114 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116622901 Nonpathogen - hypothetical protein Acid_3802 1 None None None 116619797 Common - drug resistance transporter, EmrB/QacA subfamily Acid_0667 215 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116621054 Common - Cupin 2, conserved barrel domain protein Acid_1935 35 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 116625524 Common - cobalamin B12-binding domain protein Acid_6471 114 COG2185 Sbm, Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) Lipid metabolism 116622754 Nonpathogen - hypothetical protein Acid_3653 2 None None None 116625422 Common - hypothetical protein Acid_6367 3 COG4254 COG4254, Uncharacterized protein conserved in bacteria Function unknown 116619842 Common - hypothetical protein Acid_0712 11 None None None 116624054 Common - peptidase M1, membrane alanine aminopeptidase Acid_4968 82 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 116620047 Nonpathogen - hypothetical protein Acid_0919 1 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 116623448 Common - Methyltransferase type 11 Acid_4357 5 COG4627 COG4627, Uncharacterized protein conserved in bacteria Function unknown 116620238 Common - hemolysin A Acid_1115 134 COG1189 COG1189, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 116620719 Common - peptidase S41 Acid_1599 36 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 116621200 Common - protein of unknown function DUF1080 Acid_2081 8 None None None 116625400 Common - Radical SAM domain protein Acid_6345 106 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 116625273 Common - von Willebrand factor, type A Acid_6218 16 COG2425 COG2425, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 116625805 Common - hypothetical protein Acid_6755 11 COG4485 COG4485, Predicted membrane protein Function unknown 116619936 Common - glycoside hydrolase, family 18 Acid_0808 32 COG3858 COG3858, Predicted glycosyl hydrolase General function prediction only 116625875 Nonpathogen - hypothetical protein Acid_6829 1 None None None 116621190 Common - major facilitator superfamily MFS_1 Acid_2071 204 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 116622964 Nonpathogen - hypothetical protein Acid_3867 6 COG4274 COG4274, Uncharacterized conserved protein Function unknown 116624705 Common - hypothetical protein Acid_5629 6 None None None 116621984 Common - integral membrane sensor signal transduction histidine kinase Acid_2869 119 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 116622772 Common - peptidase S9, prolyl oligopeptidase active site domain protein Acid_3671 108 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116626333 Nonpathogen - hypothetical protein Acid_7293 8 None None None 116621721 Nonpathogen - tetratricopeptide repeat protein Acid_2603 5 None None None 116626839 Common - acetyl-CoA carboxylase, biotin carboxylase Acid_7812 226 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 116619484 Common - ATPase, FliI/YscN family Acid_0343 247 COG1157 FliI, Flagellar biosynthesis/type III secretory pathway ATPase Cell motility and secretion / Intracellular trafficking and secretion 116623132 Common - dTMP kinase Acid_4038 174 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 116620821 Nonpathogen - hypothetical protein Acid_1702 1 None None None 116624192 Common - ribosomal protein L14 Acid_5108 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 116621845 Nonpathogen - RDD domain containing protein Acid_2727 2 COG1714 COG1714, Predicted membrane protein/domain Function unknown 116622024 Common - aldo/keto reductase Acid_2909 201 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116624626 Nonpathogen - hypothetical protein Acid_5550 7 None None None 116623576 Common - beta-lactamase domain protein Acid_4486 161 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 116625733 Common - cytochrome d ubiquinol oxidase, subunit II Acid_6682 150 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 116623547 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Acid_4457 131 COG0546 Gph, Predicted phosphatases General function prediction only 116626259 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Acid_7219 119 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 116619174 Common - ATP-dependent nuclease subunit B-like protein Acid_0029 16 COG3857 AddB, ATP-dependent nuclease, subunit B DNA replication, recombination, and repair 116620010 Common - Amidase Acid_0882 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 116625334 Nonpathogen - hypothetical protein Acid_6279 2 None None None 116622232 Common - Redoxin domain protein Acid_3125 131 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116625711 Common - Indigoidine synthase A family protein Acid_6660 49 COG2313 IndA, Uncharacterized enzyme involved in pigment biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 116624948 Common - hypothetical protein Acid_5877 107 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 116621271 Common - hypothetical protein Acid_2152 3 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116621324 Common - deoxyribose-phosphate aldolase Acid_2205 138 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 116619187 Common - hypothetical protein Acid_0042 59 None None None 116626445 Common - rare lipoprotein A Acid_7407 136 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 116623236 Nonpathogen - hypothetical protein Acid_4143 1 None None None 116626480 Common - glycosyl transferase, group 1 Acid_7443 28 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116619563 Common - hypothetical protein Acid_0424 11 None None None 116621951 Common - hypothetical protein Acid_2836 3 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 116620419 Nonpathogen - hypothetical protein Acid_1296 1 None None None 116626219 Common - Redoxin domain protein Acid_7179 123 COG2077 Tpx, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 116619657 Nonpathogen - protein of unknown function DUF350 Acid_0519 1 None None None 116622535 Common - hypothetical protein Acid_3433 18 None None None 116620497 Common - major facilitator superfamily MFS_1 Acid_1375 46 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 116620598 Common - ThiJ/PfpI domain protein Acid_1477 104 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 116625416 Nonpathogen - protein of unknown function UPF0132 Acid_6361 12 COG4818 COG4818, Predicted membrane protein Function unknown 116623607 Common - ABC-type uncharacterized transport system involved in gliding motility auxiliary component-like protein Acid_4517 25 COG3225 GldG, ABC-type uncharacterized transport system involved in gliding motility, auxiliary component Cell motility and secretion 116626203 Common - putative esterase Acid_7163 15 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 116626612 Common - hypothetical protein Acid_7575 24 None None None 116625677 Common - Methyltransferase type 11 Acid_6626 42 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116624798 Nonpathogen - hypothetical protein Acid_5722 10 None None None 116622244 Nonpathogen - hypothetical protein Acid_3137 1 None None None 116620003 Common - intracellular protease, PfpI family Acid_0875 167 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 116621562 Common - transcriptional regulator, ArsR family Acid_2444 14 COG0640 ArsR, Predicted transcriptional regulators Transcription 116625848 Nonpathogen - hypothetical protein Acid_6802 1 None None None 116623874 Nonpathogen - hypothetical protein Acid_4786 1 None None None 116626230 Common - ammonium transporter Acid_7190 201 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 116621651 Common - transcriptional regulator/antitoxin, MazE Acid_2533 12 COG2336 MazE, Growth regulator Signal transduction mechanisms 116623930 Common - phosphoesterase, PA-phosphatase related Acid_4842 42 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 116620412 Nonpathogen - hypothetical protein Acid_1289 6 None None None 116622775 Nonpathogen - hypothetical protein Acid_3674 1 None None None 116620868 Common - putative acetyl xylan esterase Acid_1749 8 None None None 116625177 Common - IS66 Orf2 family protein Acid_6121 47 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 116619765 Common - phage integrase family protein Acid_0632 218 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116623697 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_4609 54 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 116625303 Common - transcriptional regulator, TetR family Acid_6248 72 COG1309 AcrR, Transcriptional regulator Transcription 116625948 Nonpathogen - hypothetical protein Acid_6906 1 None None None 116619862 Common - chaperone protein DnaJ Acid_0734 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 116620861 Common - ASPIC/UnbV domain protein Acid_1742 30 None None None 116622267 Common - Palmitoyl-CoA hydrolase Acid_3161 17 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 116620119 Common - hypothetical protein Acid_0992 6 None None None 116625981 Common - Cna B domain protein Acid_6939 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116621131 Common - hypothetical protein Acid_2012 18 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116626771 Common - hypothetical protein Acid_7744 5 None None None 116623976 Nonpathogen - hypothetical protein Acid_4888 2 None None None 116626327 Common - phosphoribosyltransferase Acid_7287 48 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 116620677 Common - peptidase S41 Acid_1557 5 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 116621680 Nonpathogen - hypothetical protein Acid_2562 2 None None None 116622591 Common - hypothetical protein Acid_3489 19 None None None 116622006 Common - glycogen debranching enzyme GlgX Acid_2891 175 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 116623520 Common - polysaccharide deacetylase Acid_4430 139 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 116623647 Nonpathogen - type IV pilus assembly PilZ Acid_4559 1 None None None 116624358 Common - 6-phosphogluconolactonase Acid_5279 122 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 116620798 Common - hypothetical protein Acid_1679 12 None None None 116620775 Common - efflux transporter, RND family, MFP subunit Acid_1656 173 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116624504 Common - Acetamidase/Formamidase Acid_5428 56 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 116623389 Common - ribosomal protein S1 Acid_4298 216 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 116626054 Common - Holliday junction resolvase YqgF Acid_7012 183 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 116623505 Common - peptidase M24 Acid_4415 163 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 116619967 Common - Oxalate decarboxylase Acid_0839 15 COG2140 COG2140, Thermophilic glucose-6-phosphate isomerase and related metalloenzymes Carbohydrate transport and metabolism / General function prediction only 116619306 Nonpathogen - hypothetical protein Acid_0162 1 None None None 116620977 Common - Carbamoyl-phosphate synthase L chain, ATP-binding Acid_1858 222 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 116619256 Common - NADH-quinone oxidoreductase, E subunit Acid_0112 156 COG1905 NuoE, NADH:ubiquinone oxidoreductase 24 kD subunit Energy production and conversion 116626074 Common - major facilitator superfamily MFS_1 Acid_7032 143 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116624525 Common - hypothetical protein Acid_5449 41 None None None 116620670 Nonpathogen - hypothetical protein Acid_1550 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116626715 Common - ABC transporter related Acid_7687 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116620834 Nonpathogen - hypothetical protein Acid_1715 2 None None None 116622300 Common - nucleotide-binding protein Acid_3194 107 COG1666 COG1666, Uncharacterized protein conserved in bacteria Function unknown 116624302 Common - Alkaline phosphatase Acid_5220 54 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 116620975 Common - serine phosphatase Acid_1856 117 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 116624211 Common - phosphoesterase, PA-phosphatase related Acid_5127 15 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 116624750 Nonpathogen - hypothetical protein Acid_5674 3 None None None 116624235 Common - TonB-dependent receptor Acid_5152 24 None None None 116620410 Common - TonB family protein Acid_1287 31 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 116624347 Nonpathogen - SMP-30/Gluconolaconase/LRE domain protein Acid_5267 7 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 116619902 Common - TonB family protein Acid_0774 20 None None None 116622911 Common - rod shape-determining protein MreC Acid_3812 148 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 116620220 Common - cytochrome c, class I Acid_1097 52 COG3474 COG3474, Cytochrome c2 Energy production and conversion 116625668 Nonpathogen - O-antigen polymerase Acid_6617 1 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 116624017 Nonpathogen - hypothetical protein Acid_4929 1 None None None 116623591 Nonpathogen - hypothetical protein Acid_4501 1 None None None 116619390 Common - coenzyme A transferase Acid_0249 40 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 116621993 Common - transposase IS116/IS110/IS902 family protein Acid_2878 87 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116622612 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Acid_3510 189 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 116625607 Common - Hydrogen:quinone oxidoreductase Acid_6556 86 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 116622675 Common - Integrase, catalytic region Acid_3574 152 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116620671 Common - hypothetical protein Acid_1551 4 None None None 116625535 Common - efflux transporter, RND family, MFP subunit Acid_6482 112 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116621317 Common - transposase IS116/IS110/IS902 family protein Acid_2198 32 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116621544 Nonpathogen - hypothetical protein Acid_2426 2 COG5588 COG5588, Uncharacterized conserved protein Function unknown 116626396 Nonpathogen - hypothetical protein Acid_7356 1 None None None 116623723 Common - glycosyl transferase, family 2 Acid_4635 196 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116624672 Nonpathogen - hypothetical protein Acid_5596 1 None None None 116626878 Common - Mg chelatase, subunit ChlI Acid_7854 195 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 116623698 Common - transcriptional regulator, AraC family Acid_4610 69 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 116624632 Nonpathogen - cell surface receptor IPT/TIG domain protein Acid_5556 12 None None None 116626425 Common - hypothetical protein Acid_7387 17 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116619613 Nonpathogen - hypothetical protein Acid_0474 1 None None None 116625141 Common - ASPIC/UnbV domain protein Acid_6079 30 None None None 116623527 Common - transcriptional repressor, CopY family Acid_4437 36 COG3682 COG3682, Predicted transcriptional regulator Transcription 116619699 Nonpathogen - hypothetical protein Acid_0564 1 None None None 116621296 Common - Cna B domain protein Acid_2177 23 None None None 116623388 Common - response regulator receiver sensor signal transduction histidine kinase Acid_4297 212 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116621214 Common - ASPIC/UnbV domain protein Acid_2095 30 None None None 116624329 Common - putative esterase Acid_5247 51 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 116626164 Nonpathogen - hypothetical protein Acid_7124 1 None None None 116621363 Nonpathogen - hypothetical protein Acid_2244 4 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 116625880 Common - serine/threonine protein kinase Acid_6834 182 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116626116 Common - ATP-dependent metalloprotease FtsH Acid_7074 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 116620892 Common - Cna B domain protein Acid_1773 23 None None None 116623836 Common - hypothetical protein Acid_4748 9 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 116624204 Common - elongation factor Tu Acid_5120 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 116624621 Common - acetyl-CoA acetyltransferase Acid_5545 183 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 116626505 Common - flagellar motor switch protein FliN Acid_7468 104 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 116625156 Nonpathogen - hypothetical protein Acid_6096 1 None None None 116624354 Common - S-adenosylmethionine synthetase Acid_5274 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 116619596 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_0457 77 COG0348 NapH, Polyferredoxin Energy production and conversion 116621890 Common - Xylose isomerase domain protein TIM barrel Acid_2773 56 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116626603 Common - hypothetical protein Acid_7566 8 None None None 116624774 Common - electron transfer flavoprotein beta-subunit Acid_5698 150 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 116624292 Common - histidine ammonia-lyase Acid_5210 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 116625057 Common - outer membrane efflux protein Acid_5987 100 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116625504 Common - adenylate kinase Acid_6451 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 116621117 Common - aldo/keto reductase Acid_1998 205 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 116622814 Nonpathogen - hypothetical protein Acid_3714 8 None None None 116621615 Common - putative proteasome-type protease Acid_2497 54 COG3484 COG3484, Predicted proteasome-type protease Posttranslational modification, protein turnover, chaperones 116619417 Nonpathogen - hypothetical protein Acid_0276 1 None None None 116626889 Common - two component transcriptional regulator, LuxR family Acid_7866 216 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116619509 Common - aminotransferase, class I and II Acid_0368 240 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 116626654 Common - hypothetical protein Acid_7623 11 None None None 116623245 Common - efflux transporter, RND family, MFP subunit Acid_4152 165 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116624388 Common - alanine dehydrogenase Acid_5309 165 COG0686 Ald, Alanine dehydrogenase Amino acid transport and metabolism 116625384 Nonpathogen - hypothetical protein Acid_6329 1 None None None 116626192 Nonpathogen - hypothetical protein Acid_7152 1 None None None 116619632 Common - hypothetical protein Acid_0493 24 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 116619475 Common - transglutaminase domain protein Acid_0334 84 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 116624185 Common - ribosomal protein S5 Acid_5101 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 116626871 Common - AMP-dependent synthetase and ligase Acid_7846 220 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 116624013 Common - putative phosphoketolase Acid_4925 65 COG3957 COG3957, Phosphoketolase Carbohydrate transport and metabolism 116621630 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_2512 168 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116624224 Nonpathogen - hypothetical protein Acid_5140 2 None None None 116624359 Common - Glucose-6-P dehydrogenase subunit-like protein Acid_5280 28 COG3429 COG3429, Glucose-6-P dehydrogenase subunit Carbohydrate transport and metabolism 116626909 Common - Chorismate mutase Acid_7886 86 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 116626010 Common - cobalamin B12-binding domain protein Acid_6968 169 COG5012 COG5012, Predicted cobalamin binding protein General function prediction only 116624816 Common - hypothetical protein Acid_5740 19 None None None 116621942 Common - sec-independent translocation protein mttA/Hcf106 Acid_2827 49 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 116625577 Common - hypothetical protein Acid_6525 9 None None None 116623923 Common - Uracil-DNA glycosylase superfamily Acid_4835 128 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 116622969 Common - hypothetical protein Acid_3872 35 None None None 116626546 Common - Xylose isomerase domain protein TIM barrel Acid_7509 45 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116619201 Common - protein of unknown function UPF0150 Acid_0056 10 COG1598 COG1598, Uncharacterized conserved protein Function unknown 116621585 Nonpathogen - hypothetical protein Acid_2467 1 None None None 116621498 Nonpathogen - hypothetical protein Acid_2380 1 None None None 116626860 Common - transporter, hydrophobe/amphiphile efflux-1 (HAE1) family Acid_7835 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 116620355 Common - hypothetical protein Acid_1232 12 COG2407 FucI, L-fucose isomerase and related proteins Carbohydrate transport and metabolism 116626232 Common - nuclear protein SET Acid_7192 23 COG2940 COG2940, Proteins containing SET domain General function prediction only 116624023 Common - protein of unknown function DUF21 Acid_4935 221 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 116622372 Common - hypothetical protein Acid_3266 6 None None None 116620521 Common - glycosyl transferase, family 2 Acid_1399 35 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116621081 Common - protein of unknown function UPF0150 Acid_1962 15 COG1598 COG1598, Uncharacterized conserved protein Function unknown 116622016 Common - protein of unknown function DUF182 Acid_2901 120 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 116626677 Common - TonB-dependent receptor, plug Acid_7647 24 None None None 116619588 Common - protein of unknown function DUF72 Acid_0449 112 COG1801 COG1801, Uncharacterized conserved protein Function unknown 116624763 Common - NADH-ubiquinone oxidoreductase, chain 4L Acid_5687 166 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 116619736 Common - protein of unknown function DUF62 Acid_0601 74 COG1912 COG1912, Uncharacterized conserved protein Function unknown 116626964 Common - Pyridoxal-dependent decarboxylase Acid_7941 118 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 116626699 Common - hypothetical protein Acid_7671 11 None None None 116623963 Nonpathogen - hypothetical protein Acid_4875 1 None None None 116620934 Common - hypothetical protein Acid_1815 2 None None None 116623758 Common - Tetratricopeptide TPR_2 repeat protein Acid_4670 97 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116620885 Nonpathogen - transcriptional regulator, Fis family Acid_1766 1 None None None 116623916 Common - Peptidylprolyl isomerase Acid_4828 194 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 116624605 Common - Mannonate dehydratase Acid_5529 53 COG1312 UxuA, D-mannonate dehydratase Carbohydrate transport and metabolism 116624122 Common - WD-40 repeat protein Acid_5038 57 COG2319 COG2319, FOG: WD40 repeat General function prediction only 116624171 Nonpathogen - hypothetical protein Acid_5087 1 None None None 116623868 Common - Methenyltetrahydrofolate cyclohydrolase Acid_4780 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 116621031 Common - histone deacetylase superfamily Acid_1912 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 116625104 Nonpathogen - hypothetical protein Acid_6040 3 None None None 116619759 Nonpathogen - Radical SAM domain protein Acid_0625 2 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 116619195 Common - hypothetical protein Acid_0050 6 None None None 116620986 Common - FAD dependent oxidoreductase Acid_1867 159 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 116620514 Common - AAA ATPase Acid_1392 87 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116620618 Nonpathogen - hypothetical protein Acid_1497 1 None None None 116620991 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Acid_1872 47 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 116620963 Common - hypothetical protein Acid_1844 8 None None None 116619410 Common - hypothetical protein Acid_0269 7 None None None 116623935 Common - glycoside hydrolase, family 28 Acid_4847 20 COG5434 PGU1, Endopygalactorunase Cell envelope biogenesis, outer membrane 116623176 Common - sulfatase Acid_4083 68 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116623419 Common - conserved repeat domain Acid_4328 61 None None None 116623779 Nonpathogen - hypothetical protein Acid_4691 2 None None None 116619873 Common - polysaccharide deacetylase Acid_0745 112 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 116620150 Common - ribosomal protein L31 Acid_1023 191 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 116620148 Nonpathogen - hypothetical protein Acid_1021 1 None None None 116624120 Common - transcriptional regulator, CadC Acid_5036 54 COG3710 CadC, DNA-binding winged-HTH domains Transcription 116625068 Common - protein of unknown function DUF927 Acid_5998 30 COG5519 COG5519, Superfamily II helicase and inactivated derivatives DNA replication, recombination, and repair 116623880 Common - 2-methylcitrate synthase/citrate synthase II Acid_4792 194 COG0372 GltA, Citrate synthase Energy production and conversion 116619266 Common - TonB-dependent receptor Acid_0122 110 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 116619825 Common - cytochrome c, class I Acid_0695 61 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 116621110 Common - Tetratricopeptide TPR_2 repeat protein Acid_1991 145 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116620438 Nonpathogen - hypothetical protein Acid_1316 1 None None None 116625941 Nonpathogen - hypothetical protein Acid_6899 3 None None None 116622494 Nonpathogen - hypothetical protein Acid_3392 1 None None None 116625823 Common - Dimethylmenaquinone methyltransferase Acid_6774 72 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 116626490 Common - flagellar basal-body rod protein FlgG Acid_7453 126 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 116625215 Common - Allergen V5/Tpx-1 family protein Acid_6160 70 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 116626527 Common - membrane protein-like protein Acid_7490 17 COG5305 COG5305, Predicted membrane protein Function unknown 116623886 Nonpathogen - lipopolysaccharide biosynthesis Acid_4798 1 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 116622567 Nonpathogen - hypothetical protein Acid_3465 1 None None None 116619407 Common - hypothetical protein Acid_0266 3 None None None 116624719 Common - Cystathionine gamma-synthase Acid_5643 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 116621072 Common - glycosyl hydrolase, BNR repeat-containing protein Acid_1953 39 None None None 116622805 Nonpathogen - hypothetical protein Acid_3705 1 None None None 116619626 Nonpathogen - hypothetical protein Acid_0487 3 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116625657 Nonpathogen - hypothetical protein Acid_6606 1 None None None 116622389 Nonpathogen - hypothetical protein Acid_3283 1 None None None 116626971 Nonpathogen - hypothetical protein Acid_7948 2 None None None 116620644 Nonpathogen - hypothetical protein Acid_1523 1 None None None 116622276 Common - MiaB-like tRNA modifying enzyme Acid_3170 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 116623844 Common - alanyl-tRNA synthetase Acid_4756 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116625362 Common - DNA-3-methyladenine glycosylase II Acid_6307 112 COG0122 AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 116623056 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Acid_3960 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 116623094 Nonpathogen - Late embryogenesis abundant protein Acid_3998 1 None None None 116621629 Nonpathogen - hypothetical protein Acid_2511 1 None None None 116619493 Common - Pyruvate dehydrogenase (acetyl-transferring) Acid_0352 156 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 116623515 Common - transcriptional regulator, Fis family Acid_4425 158 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116623078 Common garR tartronate semialdehyde reductase Acid_3982 185 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 116623438 Nonpathogen - hypothetical protein Acid_4347 1 None None None 116625113 Nonpathogen - hypothetical protein Acid_6049 1 None None None 116626267 Common - transcriptional regulator, ArsR family Acid_7227 152 COG0640 ArsR, Predicted transcriptional regulators Transcription 116620227 Common - 3-hydroxybutyryl-CoA dehydrogenase Acid_1104 159 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 116621657 Nonpathogen - hypothetical protein Acid_2539 2 None None None 116626945 Common - glycosyl transferase, family 2 Acid_7922 161 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 116625771 Common - amidohydrolase Acid_6721 38 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116622458 Common - Cna B domain protein Acid_3356 22 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116624926 Common - protein of unknown function UPF0150 Acid_5853 17 COG1598 COG1598, Uncharacterized conserved protein Function unknown 116624287 Common - protein of unknown function UPF0150 Acid_5205 27 COG1598 COG1598, Uncharacterized conserved protein Function unknown 116623424 Nonpathogen - hypothetical protein Acid_4333 1 None None None 116624875 Common - efflux transporter, RND family, MFP subunit Acid_5799 161 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116625764 Common - cobalamin (vitamin B12) biosynthesis CbiM protein Acid_6714 83 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 116621699 Nonpathogen - hypothetical protein Acid_2581 1 None None None 116622941 Common - SSS sodium solute transporter superfamily Acid_3843 142 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 116623181 Common - OmpA/MotB domain protein Acid_4088 146 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 116621763 Nonpathogen - hypothetical protein Acid_2645 1 None None None 116625047 Nonpathogen - hypothetical protein Acid_5977 1 None None None 116625631 Common - short-chain dehydrogenase/reductase SDR Acid_6580 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116626581 Common - NAD-dependent epimerase/dehydratase Acid_7544 229 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116626681 Common - hypothetical protein Acid_7652 12 COG3391 COG3391, Uncharacterized conserved protein Function unknown 116622474 Common - protein of unknown function DUF309 Acid_3372 27 COG1547 COG1547, Uncharacterized conserved protein Function unknown 116623568 Common - NADP oxidoreductase, coenzyme F420-dependent Acid_4478 37 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 116621243 Common - amino acid permease-associated region Acid_2124 191 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 116624887 Common - hypothetical protein Acid_5811 11 COG3305 COG3305, Predicted membrane protein Function unknown 116624223 Common - outer membrane efflux protein Acid_5139 68 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116621381 Common - biotin/lipoyl attachment domain-containing protein Acid_2262 40 COG1038 PycA, Pyruvate carboxylase Energy production and conversion 116626579 Common - DEAD/DEAH box helicase domain protein Acid_7542 233 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 116619608 Common - peptidase S9B, dipeptidylpeptidase IV domain protein Acid_0469 85 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116624070 Common - sortase family protein Acid_4984 33 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 116623060 Common - serine/threonine protein kinase with TPR repeats Acid_3964 159 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116620602 Common - PfkB domain protein Acid_1481 180 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 116623717 Common - hypothetical protein Acid_4629 3 None None None 116626733 Common - transcriptional regulator, BadM/Rrf2 family Acid_7705 167 COG1959 COG1959, Predicted transcriptional regulator Transcription 116620781 Nonpathogen - hypothetical protein Acid_1662 1 None None None 116619464 Common - Ethanolamine utilization protein EutN/carboxysome structural protein Ccml Acid_0323 32 COG4576 CcmL, Carbon dioxide concentrating mechanism/carboxysome shell protein Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion 116622746 Common - dihydrodipicolinate synthetase Acid_3645 114 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 116620947 Nonpathogen - hypothetical protein Acid_1828 7 COG1874 LacA, Beta-galactosidase Carbohydrate transport and metabolism 116624616 Nonpathogen - putative transmembrane anti-sigma factor Acid_5540 2 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 116622485 Common - von Willebrand factor, type A Acid_3383 7 None None None 116626880 Common - replicative DNA helicase Acid_7856 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 116620747 Common - serine/threonine protein kinase with TPR repeats Acid_1628 154 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116619819 Common - plasmid maintenance system antidote protein, XRE family Acid_0689 80 COG3093 VapI, Plasmid maintenance system antidote protein General function prediction only 116625092 Common - transcriptional regulator, LuxR family Acid_6027 20 COG2771 CsgD, DNA-binding HTH domain-containing proteins Transcription 116619550 Common - alkylhydroperoxidase, AhpD family Acid_0411 28 COG2128 COG2128, Uncharacterized conserved protein Function unknown 116620867 Nonpathogen - hypothetical protein Acid_1748 1 None None None 116620373 Common - glycoside hydrolase, family 28 Acid_1250 29 COG5434 PGU1, Endopygalactorunase Cell envelope biogenesis, outer membrane 116622463 Common - signal transduction histidine kinase, nitrogen specific, NtrB Acid_3361 223 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 116626199 Common - shikimate 5-dehydrogenase Acid_7159 222 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 116622299 Common - response regulator receiver protein Acid_3193 130 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 116624917 Nonpathogen - hypothetical protein Acid_5843 4 None None None 116620712 Common - TPR repeat-containing protein Acid_1592 41 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116622702 Common - Isoprenylcysteine carboxyl methyltransferase Acid_3601 26 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 116626358 Nonpathogen - hypothetical protein Acid_7318 2 None None None 116620122 Nonpathogen - hypothetical protein Acid_0995 2 None None None 116620207 Common - major facilitator superfamily MFS_1 Acid_1080 96 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 116625238 Common - sulfatase Acid_6183 106 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116623374 Common - GCN5-related N-acetyltransferase Acid_4283 21 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 116625123 Common - IstB domain protein ATP-binding protein Acid_6060 90 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 116619566 Nonpathogen - hypothetical protein Acid_0427 1 None None None 116621641 Nonpathogen - hypothetical protein Acid_2523 1 None None None 116624598 Nonpathogen - hypothetical protein Acid_5522 1 None None None 116623850 Common - short-chain dehydrogenase/reductase SDR Acid_4762 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116626379 Common hslU ATP-dependent protease ATP-binding subunit Acid_7339 215 COG1220 HslU, ATP-dependent protease HslVU (ClpYQ), ATPase subunit Posttranslational modification, protein turnover, chaperones 116622752 Common - hypothetical protein Acid_3651 13 None None None 116623324 Nonpathogen - hypothetical protein Acid_4233 1 COG3088 CcmH, Uncharacterized protein involved in biosynthesis of c-type cytochromes Posttranslational modification, protein turnover, chaperones 116626417 Nonpathogen - hypothetical protein Acid_7379 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116619570 Common - cytochrome b subunit of formate dehydrogenase-like protein Acid_0431 21 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 116626891 Common - cation diffusion facilitator family transporter Acid_7868 208 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 116625696 Nonpathogen - hypothetical protein Acid_6645 2 None None None 116626200 Common - Amidase Acid_7160 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 116625094 Common - hypothetical protein Acid_6030 3 None None None 116623500 Common arsM arsenite S-adenosylmethyltransferase Acid_4410 168 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116621531 Nonpathogen - hypothetical protein Acid_2413 6 None None None 116621065 Common - Tetratricopeptide TPR_4 Acid_1946 48 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116620266 Nonpathogen - hypothetical protein Acid_1143 1 None None None 116626006 Common - conserved hypothetical protein, signal peptide and transmembrane prediction Acid_6964 6 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116621679 Nonpathogen - hypothetical protein Acid_2561 14 None None None 116625861 Common - aldo/keto reductase Acid_6815 136 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 116622866 Common - 4-oxalocrotonate tautomerase Acid_3767 17 COG1942 COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog General function prediction only 116623665 Common - Pyrrolo-quinoline quinone Acid_4577 73 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116625554 Common - Thiosulfate sulfurtransferase Acid_6501 145 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 116624654 Common - protein of unknown function DUF214 Acid_5578 91 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116621491 Nonpathogen - Calcium-binding EF-hand-containing protein Acid_2373 5 None None None 116621368 Common - NAD-dependent epimerase/dehydratase Acid_2249 232 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116621635 Common - beta-lactamase domain protein Acid_2517 21 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 116619853 Common - GCN5-related N-acetyltransferase Acid_0725 92 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 116626670 Common - RNA-directed DNA polymerase (Reverse transcriptase) Acid_7639 96 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 116621771 Nonpathogen - hypothetical protein Acid_2653 3 None None None 116622736 Common - integral membrane sensor signal transduction histidine kinase Acid_3635 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116624871 Common - arginine deiminase Acid_5795 51 COG2235 ArcA, Arginine deiminase Amino acid transport and metabolism 116623897 Common - hypothetical protein Acid_4809 19 None None None 116622800 Common - hypothetical protein Acid_3700 8 None None None 116621195 Common - major facilitator superfamily MFS_1 Acid_2076 25 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 116625644 Common - hypothetical protein Acid_6593 7 None None None 116625986 Common - ABC-2 type transporter Acid_6944 85 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116623561 Nonpathogen - hypothetical protein Acid_4471 1 None None None 116620389 Common - Squalene/phytoene synthase Acid_1266 117 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 116624882 Common - carbonic anhydrase Acid_5806 131 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 116619559 Common - sugar isomerase family protein Acid_0420 31 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 116623819 Nonpathogen - hypothetical protein Acid_4731 1 None None None 116619993 Common - amidase Acid_0865 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 116625623 Common - hypothetical protein Acid_6572 12 None None None 116621403 Common - Beta-lactamase Acid_2285 64 COG2367 PenP, Beta-lactamase class A Defense mechanisms 116621665 Nonpathogen - hypothetical protein Acid_2547 1 None None None 116626639 Common - Chromosomal replication initiator, DnaA C-terminal domain Acid_7604 14 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 116626096 Common - Prephenate dehydratase Acid_7054 211 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 116626561 Common - peptidase M16 domain protein Acid_7524 181 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 116622388 Common - Xylose isomerase domain protein TIM barrel Acid_3282 9 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116625026 Common - protein of unknown function DUF6, transmembrane Acid_5956 11 COG2510 COG2510, Predicted membrane protein Function unknown 116623610 Common - isochorismatase hydrolase Acid_4520 77 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 116625990 Nonpathogen - hypothetical protein Acid_6948 1 None None None 116623903 Common - transcriptional repressor, CopY family Acid_4815 25 COG3682 COG3682, Predicted transcriptional regulator Transcription 116620876 Common - transcriptional regulator, MerR family Acid_1757 122 COG0789 SoxR, Predicted transcriptional regulators Transcription 116620231 Common - Planctomycete cytochrome C Acid_1108 76 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 116623783 Common - phage integrase family protein Acid_4695 39 COG0582 XerC, Integrase DNA replication, recombination, and repair 116623384 Common fumC fumarate hydratase Acid_4293 220 COG0114 FumC, Fumarase Energy production and conversion 116623413 Nonpathogen - hypothetical protein Acid_4322 1 None None None 116621920 Common asnC asparaginyl-tRNA synthetase Acid_2805 244 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 116622619 Common - hypothetical protein Acid_3518 13 COG4371 COG4371, Predicted membrane protein Function unknown 116620065 Nonpathogen - hypothetical protein Acid_0937 1 None None None 116625759 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Acid_6709 56 None None None 116619688 Common - UDP-glucose/GDP-mannose dehydrogenase Acid_0553 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 116621526 Common - protein of unknown function DUF214 Acid_2408 103 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622553 Nonpathogen - hypothetical protein Acid_3451 1 None None None 116621237 Common - glycosyl transferase, group 1 Acid_2118 62 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116624785 Common - protein of unknown function DUF1549 Acid_5709 10 None None None 116626959 Common - secretion protein HlyD family protein Acid_7936 163 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116623088 Common - transcriptional regulator, PadR-like family Acid_3992 47 COG1695 COG1695, Predicted transcriptional regulators Transcription 116623677 Common - ABC transporter related Acid_4589 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 116623399 Common - hypothetical protein Acid_4308 3 None None None 116624982 Common - thioesterase superfamily protein Acid_5912 120 COG0824 FcbC, Predicted thioesterase General function prediction only 116625962 Common - isochorismatase hydrolase Acid_6920 101 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 116625209 Common - dihydroorotase Acid_6154 82 COG3964 COG3964, Predicted amidohydrolase General function prediction only 116619214 Common - (Glutamate--ammonia-ligase) adenylyltransferase Acid_0069 119 COG1391 GlnE, Glutamine synthetase adenylyltransferase Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms 116621730 Common - bacterioferritin Acid_2612 111 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 116624800 Nonpathogen - hypothetical protein Acid_5724 2 None None None 116622527 Common - hypothetical protein Acid_3425 7 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 116625665 Nonpathogen - hypothetical protein Acid_6614 4 None None None 116626171 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_7131 47 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 116621307 Common - two component transcriptional regulator, LuxR family Acid_2188 209 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 116623621 Common - protein of unknown function DUF1080 Acid_4531 9 None None None 116626855 Common - peptidase M14, carboxypeptidase A Acid_7828 12 None None None 116619749 Common - glycosyl transferase, family 2 Acid_0615 202 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116626181 Common - glutathionylspermidine synthase Acid_7141 54 COG0754 Gsp, Glutathionylspermidine synthase Amino acid transport and metabolism 116622362 Nonpathogen - DoxX family protein Acid_3256 1 COG2259 COG2259, Predicted membrane protein Function unknown 116620730 Nonpathogen - hypothetical protein Acid_1611 1 None None None 116619375 Common - protein of unknown function DUF796 Acid_0233 30 COG3157 Hcp, Hemolysin-coregulated protein (uncharacterized) Function unknown 116624769 Common - beta-lactamase domain protein Acid_5693 125 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 116624524 Common - 8-amino-7-oxononanoate synthase Acid_5448 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 116620120 Common - ABC transporter related Acid_0993 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 116624693 Common - hypothetical protein Acid_5617 78 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 116620585 Nonpathogen - hypothetical protein Acid_1464 7 None None None 116624449 Common - CheD Acid_5371 84 COG1871 CheD, Chemotaxis protein; stimulates methylation of MCP proteins Cell motility and secretion / Signal transduction mechanisms 116620085 Common ruvB Holliday junction DNA helicase B Acid_0957 238 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 116623751 Nonpathogen - hypothetical protein Acid_4663 8 None None None 116621105 Common - Na+/melibiose symporter and related transporter-like protein Acid_1986 90 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 116623278 Common - Trans-aconitate 2-methyltransferase Acid_4185 83 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 116622715 Common - Radical SAM domain protein Acid_3614 81 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 116626910 Common - tryptophan synthase, alpha subunit Acid_7887 215 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 116626626 Common - tetratricopeptide repeat protein Acid_7589 20 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 116621737 Common - TonB-dependent receptor Acid_2619 3 COG3147 DedD, Uncharacterized protein conserved in bacteria Function unknown 116624857 Common - Radical SAM domain protein Acid_5781 76 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 116626311 Common - Spermine synthase Acid_7271 117 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 116625387 Common - secretion protein HlyD family protein Acid_6332 116 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 116619318 Nonpathogen - von Willebrand factor, type A Acid_0175 6 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 116626796 Common - response regulator receiver protein Acid_7769 10 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 116624244 Common - Integrase, catalytic region Acid_5161 152 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116622369 Common - hypothetical protein Acid_3263 4 None None None 116622169 Nonpathogen - hypothetical protein Acid_3061 1 None None None 116624850 Common - hypothetical protein Acid_5774 5 COG0628 PerM, Predicted permease General function prediction only 116625938 Common - heavy metal sensor signal transduction histidine kinase Acid_6896 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116619686 Common - putative translaldolase Acid_0551 100 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 116626617 Common - cytochrome c oxidase, subunit II Acid_7580 158 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 116624928 Common - FAD dependent oxidoreductase Acid_5855 99 COG0579 COG0579, Predicted dehydrogenase General function prediction only 116619363 Nonpathogen - hypothetical protein Acid_0221 1 None None None 116620663 Nonpathogen - hypothetical protein Acid_1543 5 None None None 116624091 Common - glycoside hydrolase, family 3 domain protein Acid_5006 141 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 116621626 Nonpathogen - hypothetical protein Acid_2508 6 None None None 116626882 Nonpathogen - hypothetical protein Acid_7858 2 None None None 116619975 Nonpathogen - hypothetical protein Acid_0847 5 None None None 116620459 Nonpathogen - Glyoxalase/bleomycin resistance protein/dioxygenase Acid_1337 1 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 116624068 Common - AMP-dependent synthetase and ligase Acid_4982 222 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116619675 Common - Pyrrolo-quinoline quinone Acid_0538 62 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116623907 Common - TonB family protein Acid_4819 46 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 116622658 Common - hypothetical protein Acid_3557 10 None None None 116619316 Nonpathogen - hypothetical protein Acid_0173 1 None None None 116619763 Common - phage integrase family protein Acid_0629 188 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116622459 Common - serine/threonine protein kinase Acid_3357 179 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116625352 Common - hypothetical protein Acid_6297 23 COG0657 Aes, Esterase/lipase Lipid metabolism 116625830 Common - protein of unknown function DUF1680 Acid_6783 30 COG3533 COG3533, Uncharacterized protein conserved in bacteria Function unknown 116623956 Common - protein of unknown function DUF344 Acid_4868 127 COG2326 COG2326, Uncharacterized conserved protein Function unknown 116621043 Common - ABC transporter related Acid_1924 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 116623322 Common - cytochrome c-type biogenesis protein, CcmE-like protein Acid_4231 56 COG2332 CcmE, Cytochrome c-type biogenesis protein CcmE Posttranslational modification, protein turnover, chaperones 116623433 Common - glycosyl transferase, family 2 Acid_4342 138 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 116621164 Common - response regulator receiver protein Acid_2045 212 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116621577 Common - Integrase, catalytic region Acid_2459 152 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116619794 Common - hypothetical protein Acid_0664 13 None None None 116626661 Common - hypothetical protein Acid_7630 37 None None None 116622379 Nonpathogen - FHA domain containing protein Acid_3273 1 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 116622609 Common - cytochrome c oxidase, subunit I Acid_3507 149 COG3278 CcoN, Cbb3-type cytochrome oxidase, subunit 1 Posttranslational modification, protein turnover, chaperones 116625257 Common - beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ Acid_6202 187 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 116626713 Nonpathogen - hypothetical protein Acid_7685 8 None None None 116620783 Common - protein of unknown function DUF214 Acid_1664 58 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116625611 Common - hypothetical protein Acid_6560 7 None None None 116621153 Common - heat shock protein DnaJ domain protein Acid_2034 221 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 116622305 Common - Cna B domain protein Acid_3199 23 COG4772 FecA, Outer membrane receptor for Fe3+-dicitrate Inorganic ion transport and metabolism 116622223 Common - hypothetical protein Acid_3116 9 COG5628 COG5628, Predicted acetyltransferase General function prediction only 116619829 Common - TonB family protein Acid_0699 38 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 116620856 Common - protein of unknown function DUF214 Acid_1737 113 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116622212 Common - TonB-dependent receptor Acid_3104 24 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116624565 Common - peptidase M56, BlaR1 Acid_5489 27 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 116619461 Common - class II aldolase/adducin family protein Acid_0320 127 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 116622653 Common - peptidase M28 Acid_3552 21 COG2234 Iap, Predicted aminopeptidases General function prediction only 116623257 Nonpathogen - hypothetical protein Acid_4164 1 None None None 116623984 Common - hypothetical protein Acid_4896 5 None None None 116624745 Nonpathogen - hypothetical protein Acid_5669 5 None None None 116620903 Common - short-chain dehydrogenase/reductase SDR Acid_1784 233 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116621600 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_2482 160 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116624385 Common - sulfatase Acid_5306 79 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 116620737 Nonpathogen - hypothetical protein Acid_1618 8 None None None 116620680 Common - Redoxin domain protein Acid_1560 39 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 116621901 Common - hypothetical protein Acid_2786 15 COG5646 COG5646, Uncharacterized conserved protein Function unknown 116625859 Nonpathogen - hypothetical protein Acid_6813 1 None None None 116622885 Common - protein of unknown function DUF214 Acid_3786 121 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116623290 Nonpathogen - hypothetical protein Acid_4197 1 None None None 116619443 Common - Radical SAM domain protein Acid_0302 178 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 116621718 Nonpathogen - hypothetical protein Acid_2600 6 None None None 116624481 Common - hypothetical protein Acid_5403 21 None None None 116620607 Common - putative translation initiation factor, aIF-2BI family Acid_1486 132 COG0182 COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 116620127 Common - protein of unknown function DUF433 Acid_1000 9 COG2442 COG2442, Uncharacterized conserved protein Function unknown 116623298 Common - Polysulphide reductase, NrfD Acid_4205 46 COG5557 COG5557, Polysulphide reductase Energy production and conversion 116626457 Common - metal dependent phosphohydrolase Acid_7419 47 COG3481 COG3481, Predicted HD-superfamily hydrolase General function prediction only 116620186 Common smpB SsrA-binding protein Acid_1059 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 116621783 Common - Cna B domain protein Acid_2665 23 None None None 116622038 Nonpathogen - hypothetical protein Acid_2923 2 None None None 116626590 Common - response regulator receiver protein Acid_7553 51 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116620424 Common - hypothetical protein Acid_1301 7 COG3349 COG3349, Uncharacterized conserved protein Function unknown 116620988 Common - Pyridoxal-5'-phosphate-dependent enzyme, beta subunit Acid_1869 220 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 116621219 Common - Alpha-N-arabinofuranosidase Acid_2100 29 COG3534 AbfA, Alpha-L-arabinofuranosidase Carbohydrate transport and metabolism 116619654 Common - deoxyribose-phosphate aldolase Acid_0515 125 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 116624958 Nonpathogen - hypothetical protein Acid_5887 1 None None None 116624003 Common - glycerophosphoryl diester phosphodiesterase Acid_4915 164 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 116620966 Common - Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein Acid_1847 137 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116619147 Common - DNA polymerase III, beta subunit Acid_0002 215 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 116626306 Common - von Willebrand factor, type A Acid_7266 14 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 116619619 Nonpathogen - hypothetical protein Acid_0480 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116626769 Common - protein of unknown function DUF1080 Acid_7742 5 None None None 116620413 Common - hypothetical protein Acid_1290 16 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 116619452 Nonpathogen - putative transmembrane anti-sigma factor Acid_0311 1 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 116622192 Nonpathogen - hypothetical protein Acid_3084 1 None None None 116621518 Common - DNA protecting protein DprA Acid_2400 211 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 116619427 Common - NAD-dependent epimerase/dehydratase Acid_0286 221 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116619716 Common - ABC transporter related Acid_0581 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 116625181 Common - hypothetical protein Acid_6126 2 None None None 116626283 Common - FMN-dependent alpha-hydroxy acid dehydrogenase Acid_7243 115 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 116621860 Nonpathogen - type IV pilus assembly PilZ Acid_2743 1 None None None 116624114 Common - YceI family protein Acid_5030 120 COG2353 COG2353, Uncharacterized conserved protein Function unknown 116620705 Common - peptide chain release factor 2 Acid_1585 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 116625012 Common - Xylose isomerase domain protein TIM barrel Acid_5942 8 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116619204 Common - major facilitator superfamily MFS_1 Acid_0059 176 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116623489 Nonpathogen - amidohydrolase 2 Acid_4399 9 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 116619495 Nonpathogen - hypothetical protein Acid_0354 1 None None None 116623781 Nonpathogen - hypothetical protein Acid_4693 1 None None None 116622956 Nonpathogen - hypothetical protein Acid_3858 1 None None None 116623222 Nonpathogen - electron transport protein SCO1/SenC Acid_4129 1 COG5569 COG5569, Uncharacterized conserved protein Function unknown 116625295 Nonpathogen - hypothetical protein Acid_6240 1 None None None 116619909 Common - protein of unknown function DUF6, transmembrane Acid_0781 148 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 116623462 Common - glucose-1-phosphate adenylyltransferase Acid_4372 193 COG0448 GlgC, ADP-glucose pyrophosphorylase Carbohydrate transport and metabolism 116625446 Nonpathogen - hypothetical protein Acid_6391 1 None None None 116624962 Common - hypothetical protein Acid_5891 9 COG3205 COG3205, Predicted membrane protein Function unknown 116620460 Nonpathogen - hypothetical protein Acid_1338 1 None None None 116624104 Common - NADH dehydrogenase (ubiquinone), 24 kDa subunit Acid_5019 157 COG1905 NuoE, NADH:ubiquinone oxidoreductase 24 kD subunit Energy production and conversion 116619172 Common - Xylose isomerase domain protein TIM barrel Acid_0027 32 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116622928 Common - Ion transport 2 domain protein Acid_3830 20 COG3641 PfoR, Predicted membrane protein, putative toxin regulator General function prediction only 116624807 Common - response regulator receiver and ANTAR domain protein Acid_5731 2 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 116620029 Nonpathogen - UspA domain protein Acid_0901 1 None None None 116620841 Common - protein of unknown function DUF433 Acid_1722 8 COG2442 COG2442, Uncharacterized conserved protein Function unknown 116620182 Common - FAD linked oxidase domain protein Acid_1055 199 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 116622357 Common - glycosyl hydrolase (secreted protein) Acid_3251 10 COG3828 COG3828, Uncharacterized protein conserved in bacteria Function unknown 116620464 Common - Inosine/uridine-preferring nucleoside hydrolase Acid_1342 87 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 116626114 Nonpathogen - hypothetical protein Acid_7072 2 None None None 116626551 Common - heavy metal efflux pump, CzcA family Acid_7514 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 116625474 Nonpathogen - hypothetical protein Acid_6420 2 None None None 116624779 Nonpathogen - hypothetical protein Acid_5703 1 None None None 116621997 Common - two component, sigma54 specific, transcriptional regulator, Fis family Acid_2882 219 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116622839 Nonpathogen - hypothetical protein Acid_3739 1 None None None 116619357 Common - ASPIC/UnbV domain protein Acid_0215 37 None None None 116624431 Common - isoleucyl-tRNA synthetase Acid_5353 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116626707 Common - serine/threonine protein kinase Acid_7679 211 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116624320 Nonpathogen - hypothetical protein Acid_5238 2 None None None 116626399 Nonpathogen - hypothetical protein Acid_7361 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116621925 Common - alkylhydroperoxidase like protein, AhpD family Acid_2810 30 COG2128 COG2128, Uncharacterized conserved protein Function unknown 116619150 Common - peptidase M28 Acid_0005 48 COG2234 Iap, Predicted aminopeptidases General function prediction only 116625411 Common - transposase IS116/IS110/IS902 family protein Acid_6356 87 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 116624263 Common - translation initiation factor IF-2 Acid_5181 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 116622176 Common - putative esterase Acid_3068 35 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 116620393 Nonpathogen - Mammalian cell entry related domain protein Acid_1270 5 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 116620758 Common - Quinoprotein glucose dehydrogenase Acid_1639 58 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116626121 Common - protein of unknown function DUF132 Acid_7079 9 COG1569 COG1569, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 116621258 Nonpathogen - hypothetical protein Acid_2139 4 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 116623062 Common - hypothetical protein Acid_3966 9 None None None 116619803 Common - major facilitator superfamily MFS_1 Acid_0673 162 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116621267 Common - peptidase M16 domain protein Acid_2148 194 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 116624028 Nonpathogen - hypothetical protein Acid_4940 7 None None None 116626802 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_7775 171 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116621507 Common - protein of unknown function DUF214 Acid_2389 78 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116619600 Nonpathogen - H+-transporting two-sector ATPase, B/B' subunit Acid_0461 2 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 116625263 Common - Cytochrome b/b6, N-terminal domain Acid_6208 150 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 116619295 Common - phage Tail Collar domain protein Acid_0151 39 COG4675 MdpB, Microcystin-dependent protein Function unknown 116619575 Common - hypothetical protein Acid_0436 24 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 116625130 Nonpathogen - hypothetical protein Acid_6067 1 None None None 116625509 Common - protein of unknown function DUF190 Acid_6456 51 COG1993 COG1993, Uncharacterized conserved protein Function unknown 116621333 Common - protein of unknown function DUF214 Acid_2214 123 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116621843 Common - natural resistance-associated macrophage protein Acid_2725 102 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 116626597 Common - nicotinate-nucleotide pyrophosphorylase Acid_7560 204 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 116622524 Common - Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein Acid_3422 121 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 116624254 Common - peptidase A24A domain protein Acid_5172 123 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 116619823 Common - Alpha/beta hydrolase fold-3 domain protein Acid_0693 140 COG0657 Aes, Esterase/lipase Lipid metabolism 116621141 Common - Adenylosuccinate synthase Acid_2022 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 116625839 Common - Curculin domain protein (mannose-binding) lectin Acid_6792 7 None None None 116624821 Common - hypothetical protein Acid_5745 94 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 116619534 Nonpathogen - peptidase, zinc-dependent Acid_0393 30 COG1913 COG1913, Predicted Zn-dependent proteases General function prediction only 116622791 Common - sodium:dicarboxylate symporter Acid_3691 163 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 116619691 Common - ABC transporter related Acid_0556 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 116623208 Nonpathogen - hypothetical protein Acid_4115 1 None None None 116625905 Common - transposase IS3/IS911 family protein Acid_6861 32 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 116626724 Common - arginine decarboxylase Acid_7696 124 COG1166 SpeA, Arginine decarboxylase (spermidine biosynthesis) Amino acid transport and metabolism 116622704 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_3603 62 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116623742 Common - glycosyl transferase, group 1 Acid_4654 107 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 116626276 Nonpathogen - hypothetical protein Acid_7236 1 None None None 116619277 Common - thioesterase superfamily protein Acid_0133 137 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 116625721 Common - peptide chain release factor 1 Acid_6670 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 116620159 Common - TonB family protein Acid_1032 25 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 116621484 Common - transcriptional regulator, MerR family Acid_2366 89 COG0789 SoxR, Predicted transcriptional regulators Transcription 116622503 Nonpathogen - hypothetical protein Acid_3401 1 None None None 116625547 Nonpathogen - hypothetical protein Acid_6494 1 None None None 116620311 Common - acyltransferase 3 Acid_1188 94 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 116619779 Nonpathogen - hypothetical protein Acid_0649 1 None None None 116621690 Common - ribosomal protein S16 Acid_2572 213 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 116623834 Common - transposase Acid_4746 35 COG5659 COG5659, FOG: Transposase DNA replication, recombination, and repair 116622734 Nonpathogen - hypothetical protein Acid_3633 5 None None None 116626745 Common - NUDIX hydrolase Acid_7717 169 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 116619959 Common - hypothetical protein Acid_0831 14 None None None 116621075 Nonpathogen - hypothetical protein Acid_1956 4 None None None 116625005 Common - periplasmic binding protein/LacI transcriptional regulator Acid_5935 39 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 116625887 Nonpathogen - hypothetical protein Acid_6841 1 None None None 116621848 Nonpathogen - hypothetical protein Acid_2730 2 None None None 116619946 Common - 1-phosphofructokinase Acid_0818 99 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 116624643 Common - oxidoreductase Acid_5567 33 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116626027 Common - ribokinase Acid_6985 191 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 116623584 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Acid_4494 13 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116619233 Nonpathogen - Electron transfer flavoprotein beta subunit-like protein Acid_0088 2 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 116624099 Common - peptidase M52, hydrogen uptake protein Acid_5014 22 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 116624440 Nonpathogen - hypothetical protein Acid_5362 4 COG2976 COG2976, Uncharacterized protein conserved in bacteria Function unknown 116620054 Common - amidohydrolase Acid_0926 72 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 116625448 Nonpathogen - hypothetical protein Acid_6393 1 None None None 116622106 Common - glycoside hydrolase, family 43 Acid_2993 38 COG3507 XynB, Beta-xylosidase Carbohydrate transport and metabolism 116623272 Common - rod shape-determining protein RodA Acid_4179 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 116626143 Common - ABC transporter related Acid_7101 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 116622762 Common - serine/threonine protein kinase Acid_3661 150 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116626735 Common - transcriptional regulator, PadR-like family Acid_7707 61 COG1695 COG1695, Predicted transcriptional regulators Transcription 116619890 Common - protein of unknown function DUF214 Acid_0762 46 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116621711 Common - Integrase, catalytic region Acid_2593 151 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116625019 Common - crossover junction endodeoxyribonuclease RuvC Acid_5949 198 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 116623012 Common - Abortive infection protein Acid_3916 3 None None None 116624137 Common - aminotransferase, class V Acid_5053 240 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 116621415 Common - penicillin-binding protein, transpeptidase Acid_2297 11 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 116622881 Nonpathogen - hypothetical protein Acid_3782 1 None None None 116622574 Common - Methyltransferase type 11 Acid_3472 12 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 116626431 Common - serine/threonine protein kinase Acid_7393 160 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116621177 Common - FAD linked oxidase domain protein Acid_2058 205 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 116622095 Common - Cna B-type protein Acid_2982 24 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116626511 Common - membrane-bound metal-dependent hydrolase Acid_7474 11 COG1988 COG1988, Predicted membrane-bound metal-dependent hydrolases General function prediction only 116624178 Common rpmJ 50S ribosomal protein L36 Acid_5094 137 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 116623417 Common - hypothetical protein Acid_4326 9 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 116620577 Common - response regulator receiver protein Acid_1456 188 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 116624969 Common - serine/threonine protein kinase Acid_5899 157 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116623628 Nonpathogen - hypothetical protein Acid_4540 6 None None None 116623687 Common - protein of unknown function DUF74 Acid_4599 90 COG0393 COG0393, Uncharacterized conserved protein Function unknown 116623551 Common - TonB-dependent receptor Acid_4461 21 None None None 116620894 Common - putative esterase Acid_1775 57 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 116622172 Common - hypothetical protein Acid_3064 8 None None None 116625037 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Acid_5967 45 COG0388 COG0388, Predicted amidohydrolase General function prediction only 116622634 Nonpathogen - hypothetical protein Acid_3533 3 None None None 116622335 Common - Alcohol dehydrogenase, zinc-binding domain protein Acid_3229 149 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 116619543 Common - hypothetical protein Acid_0402 25 None None None 116624208 Common - hypothetical protein Acid_5124 7 None None None 116621476 Nonpathogen - Collagen triple helix repeat Acid_2358 2 None None None 116621966 Common - Radical SAM domain protein Acid_2851 63 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 116623801 Common - 4'-phosphopantetheinyl transferase Acid_4713 58 COG2091 Sfp, Phosphopantetheinyl transferase Coenzyme metabolism 116621007 Nonpathogen - hypothetical protein Acid_1888 1 None None None 116625466 Common - serine/threonine protein kinase Acid_6412 205 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116623301 Nonpathogen - peptidase, zinc-dependent Acid_4208 30 COG1913 COG1913, Predicted Zn-dependent proteases General function prediction only 116624583 Nonpathogen - hypothetical protein Acid_5507 1 None None None 116623191 Common phhA phenylalanine 4-monooxygenase Acid_4098 45 COG3186 COG3186, Phenylalanine-4-hydroxylase Amino acid transport and metabolism 116622582 Common - ASPIC/UnbV domain protein Acid_3480 29 None None None 116624156 Common - GCN5-related N-acetyltransferase Acid_5072 102 COG0456 RimI, Acetyltransferases General function prediction only 116626030 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit alpha Acid_6988 121 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 116623145 Common - amidase, hydantoinase/carbamoylase family Acid_4051 86 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 116619183 Common - Heparinase II/III family protein Acid_0038 24 None None None 116623005 Common - addiction module toxin, Txe/YoeB family Acid_3909 52 COG4115 COG4115, Uncharacterized protein conserved in bacteria Function unknown 116622848 Common - Alpha-N-arabinofuranosidase Acid_3748 29 COG3534 AbfA, Alpha-L-arabinofuranosidase Carbohydrate transport and metabolism 116620541 Nonpathogen - hypothetical protein Acid_1419 1 None None None 116620291 Common - acyl carrier protein Acid_1168 211 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 116619926 Common - protein of unknown function DUF885 Acid_0798 43 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 116625365 Nonpathogen - type IV pilus assembly PilZ Acid_6310 1 None None None 116625972 Common - hydrogenase expression/formation protein HypE Acid_6930 188 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 116623351 Common - PAS/PAC sensor hybrid histidine kinase Acid_4260 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 116624439 Common - AAA ATPase Acid_5361 20 COG3910 COG3910, Predicted ATPase General function prediction only 116625933 Nonpathogen - hypothetical protein Acid_6890 9 None None None 116622782 Nonpathogen - hypothetical protein Acid_3681 1 None None None 116621357 Common - Methyltransferase type 12 Acid_2238 34 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 116621804 Nonpathogen - hypothetical protein Acid_2686 2 None None None 116621015 Common - transcriptional regulator, ArsR family Acid_1896 65 COG4189 COG4189, Predicted transcriptional regulator Transcription 116620548 Common - OmpA/MotB domain protein Acid_1426 130 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 116623071 Common - DNA gyrase, A subunit Acid_3975 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 116621520 Common - integral membrane sensor signal transduction histidine kinase Acid_2402 220 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 116626525 Common - PepSY-associated TM helix domain protein Acid_7488 29 COG3295 COG3295, Uncharacterized protein conserved in bacteria Function unknown 116621027 Common - GTP cyclohydrolase II Acid_1908 229 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 116624535 Common - ribosomal protein L10 Acid_5459 199 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 116621108 Common - ASPIC/UnbV domain protein Acid_1989 31 None None None 116624145 Common - Dyp-type peroxidase family Acid_5061 24 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 116625846 Common - phage integrase family protein Acid_6800 21 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 116622260 Nonpathogen - hypothetical protein Acid_3154 1 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 116619168 Common - oxidoreductase domain protein Acid_0023 82 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116622205 Common - Quinoprotein glucose dehydrogenase Acid_3097 60 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 116624298 Common - protein of unknown function DUF214 Acid_5216 12 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116626683 Common - single-strand binding protein Acid_7654 140 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 116624132 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Acid_5048 9 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116620456 Common - class II aldolase/adducin family protein Acid_1334 132 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 116620484 Common - short-chain dehydrogenase/reductase SDR Acid_1362 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 116619659 Nonpathogen - hypothetical protein Acid_0521 1 None None None 116619837 Common - hypothetical protein Acid_0707 3 None None None 116624341 Common - FAD linked oxidase domain protein Acid_5259 55 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 116625793 Common - ABC transporter related Acid_6743 249 COG1137 YhbG, ABC-type (unclassified) transport system, ATPase component General function prediction only 116625340 Nonpathogen - hypothetical protein Acid_6285 1 None None None 116623108 Common - hypothetical protein Acid_4012 3 None None None 116619223 Nonpathogen - hypothetical protein Acid_0078 2 None None None 116626950 Common - acetate--CoA ligase Acid_7927 213 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 116625516 Nonpathogen - hypothetical protein Acid_6463 1 None None None 116626438 Nonpathogen - DinB family protein Acid_7400 1 COG2318 DinB, Uncharacterized protein conserved in bacteria Function unknown 116619466 Common - protein of unknown function DUF180 Acid_0325 33 COG1699 COG1699, Uncharacterized protein conserved in bacteria Function unknown 116619966 Common - Formate dehydrogenase Acid_0838 171 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 116620829 Nonpathogen - hypothetical protein Acid_1710 1 None None None 116626368 Common - Phospholipase C Acid_7328 34 COG3511 PlcC, Phospholipase C Cell envelope biogenesis, outer membrane 116620222 Nonpathogen - hypothetical protein Acid_1099 1 None None None 116626763 Common - TonB-dependent receptor Acid_7736 18 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116619392 Common - beta-ketoadipyl CoA thiolase Acid_0251 167 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 116619989 Common - beta-lactamase domain protein Acid_0861 26 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 116624976 Common - NAD-dependent epimerase/dehydratase Acid_5906 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 116620639 Common - oxidoreductase domain protein Acid_1518 176 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116621092 Common - beta-ketoacyl synthase Acid_1973 210 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 116619346 Common - glycogen debranching enzyme-like protein Acid_0204 49 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 116620657 Common - histidyl-tRNA synthetase Acid_1537 249 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 116621858 Nonpathogen - hypothetical protein Acid_2741 1 None None None 116622548 Nonpathogen - hypothetical protein Acid_3446 1 None None None 116621000 Common - ABC transporter related Acid_1881 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116625701 Common - peptidase M24 Acid_6650 235 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 116625004 Common - RhaT l-rhamnose-proton symport 2 Acid_5934 14 None None None 116622898 Common - oxidoreductase domain protein Acid_3799 167 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 116625170 Common - inner-membrane translocator Acid_6114 124 COG4603 COG4603, ABC-type uncharacterized transport system, permease component General function prediction only 116622996 Common - Endopeptidase Clp Acid_3900 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 116620912 Nonpathogen - hypothetical protein Acid_1793 2 None None None 116626409 Nonpathogen - hypothetical protein Acid_7371 1 None None None 116621814 Common - peptidase M36, fungalysin Acid_2696 22 None None None 116620806 Common - DNA mismatch endonuclease vsr Acid_1687 71 COG3727 Vsr, DNA G:T-mismatch repair endonuclease DNA replication, recombination, and repair 116623101 Common - hypothetical protein Acid_4005 40 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 116623262 Common - multi-sensor signal transduction histidine kinase Acid_4169 211 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 116622830 Common - von Willebrand factor, type A Acid_3730 15 COG4867 COG4867, Uncharacterized protein with a von Willebrand factor type A (vWA) domain General function prediction only 116626400 Common - Nucleotidyl transferase Acid_7362 233 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 116625914 Common - hypothetical protein Acid_6871 23 None None None 116626133 Common - ribosomal protein L9 Acid_7091 216 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 116625811 Common - conserved repeat domain Acid_6762 30 None None None 116619743 Nonpathogen - hypothetical protein Acid_0608 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116622827 Common - alpha/beta hydrolase fold Acid_3727 46 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 116626240 Common - radical SAM enzyme, Cfr family Acid_7200 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 116623340 Nonpathogen - hypothetical protein Acid_4249 1 None None None 116619190 Common - type II secretion system protein E Acid_0045 218 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 116623406 Nonpathogen - hypothetical protein Acid_4315 8 None None None 116620530 Nonpathogen - hypothetical protein Acid_1408 15 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 116622406 Common - Carboxymuconolactone decarboxylase Acid_3301 87 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 116621370 Common - acyltransferase 3 Acid_2251 111 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 116619269 Common - protein of unknown function DUF71, ATP-binding region Acid_0125 39 COG2102 COG2102, Predicted ATPases of PP-loop superfamily General function prediction only 116622323 Common - oxidoreductase, molybdopterin binding Acid_3217 131 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 116622558 Common - extracellular solute-binding protein, family 5 Acid_3456 207 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 116626818 Nonpathogen - hypothetical protein Acid_7791 1 None None None 116621283 Common - two component transcriptional regulator, winged helix family Acid_2164 218 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116619260 Common - NADH-ubiquinone/plastoquinone oxidoreductase, chain 6 Acid_0116 147 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 116619400 Common - hypothetical protein Acid_0259 4 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 116625135 Common - short-chain dehydrogenase/reductase SDR Acid_6072 59 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 116619869 Common - beta-lactamase domain protein Acid_0741 91 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 116625455 Common - peptidase S1 and S6, chymotrypsin/Hap Acid_6400 221 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 116621465 Nonpathogen - hypothetical protein Acid_2347 1 None None None 116619582 Nonpathogen - hypothetical protein Acid_0443 2 None None None 116625087 Nonpathogen - hypothetical protein Acid_6021 1 None None None 116620229 Common - alkaline phosphatase, DedA family Acid_1106 159 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 116620741 Common - hypothetical protein Acid_1622 19 None None None 116619234 Common - lipolytic enzyme, G-D-S-L family Acid_0089 6 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116619245 Nonpathogen - hypothetical protein Acid_0101 1 None None None 116625370 Common - peptidase M28 Acid_6315 59 COG2234 Iap, Predicted aminopeptidases General function prediction only 116623999 Nonpathogen - hypothetical protein Acid_4911 1 None None None 116625595 Common - hypothetical protein Acid_6544 4 None None None 116626045 Common - response regulator receiver protein Acid_7003 176 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 116620625 Common - Integrase, catalytic region Acid_1504 151 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 116621254 Common - peptidase M23B Acid_2135 145 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 116622662 Nonpathogen - hypothetical protein Acid_3561 2 None None None 116626019 Nonpathogen - hypothetical protein Acid_6977 1 None None None 116623138 Nonpathogen - hypothetical protein Acid_4044 1 None None None 116621350 Common - amidohydrolase Acid_2231 131 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 116621209 Common - lipolytic enzyme, G-D-S-L family Acid_2090 17 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 116622228 Nonpathogen - hypothetical protein Acid_3121 1 None None None 116619301 Common - PAS/PAC sensor hybrid histidine kinase Acid_0157 220 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 116624202 Common - ribosomal protein L3 Acid_5118 225 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 116619197 Common - aspartate kinase Acid_0052 236 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 116623478 Common - Rieske (2Fe-2S) domain protein Acid_4388 79 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 116624406 Common - hypothetical protein Acid_5328 22 COG0392 COG0392, Predicted integral membrane protein Function unknown 116626155 Common - bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein Acid_7115 186 COG0646 MetH, Methionine synthase I (cobalamin-dependent), methyltransferase domain Amino acid transport and metabolism 116624722 Common - major facilitator superfamily MFS_1 Acid_5646 191 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 116626088 Nonpathogen - hypothetical protein Acid_7046 1 None None None 116625587 Common - amidohydrolase 2 Acid_6536 47 COG3618 COG3618, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 116619386 Common - 3-carboxy-cis,cis-muconate cycloisomerase Acid_0245 191 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 116624047 Common - Appr-1-p processing domain protein Acid_4961 112 COG2110 COG2110, Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 General function prediction only 116621386 Nonpathogen - hypothetical protein Acid_2267 1 None None None 116623401 Common - cyclic nucleotide-binding protein Acid_4310 136 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 116625024 Common - Xylose isomerase domain protein TIM barrel Acid_5954 9 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116620407 Common - Tetratricopeptide TPR_2 repeat protein Acid_1284 21 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 116620509 Common - peptidase S41 Acid_1387 166 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 116622834 Common - hypothetical protein Acid_3734 13 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 116626104 Common - hypothetical protein Acid_7062 5 COG1598 COG1598, Uncharacterized conserved protein Function unknown 116623358 Common - protein of unknown function DUF214 Acid_4267 148 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116624606 Common - sodium/hydrogen exchanger Acid_5530 186 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 116620981 Common - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Acid_1862 196 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 116625326 Common - serine/threonine protein kinase Acid_6271 144 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116623201 Common - hypothetical protein Acid_4108 12 None None None 116624455 Common - sortase family protein Acid_5377 40 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 116623020 Nonpathogen - hypothetical protein Acid_3924 2 None None None 116626740 Common - protein of unknown function UPF0054 Acid_7712 39 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 116622978 Nonpathogen - hypothetical protein Acid_3881 1 None None None 116626537 Common - transcriptional regulator, LuxR family Acid_7500 91 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 116619161 Common - Cobyrinic acid a,c-diamide synthase Acid_0016 219 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 116622603 Common - hypothetical protein Acid_3501 35 None None None 116625195 Nonpathogen - hypothetical protein Acid_6140 7 None None None 116621036 Common - transcriptional regulator, ArsR family Acid_1917 72 COG0640 ArsR, Predicted transcriptional regulators Transcription 116619399 Common - hypothetical protein Acid_0258 9 None None None 116623347 Common - ABC transporter related Acid_4256 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 116623808 Nonpathogen - hypothetical protein Acid_4720 1 None None None 116621456 Common - DegT/DnrJ/EryC1/StrS aminotransferase Acid_2338 192 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 116624424 Common - hypothetical protein Acid_5346 2 None None None 116621541 Common - hypothetical protein Acid_2423 14 COG1106 COG1106, Predicted ATPases General function prediction only 116619721 Nonpathogen - membrane protein-like protein Acid_0586 3 COG5373 COG5373, Predicted membrane protein Function unknown 116622048 Common - Hemerythrin HHE cation binding domain protein Acid_2934 18 COG3945 COG3945, Uncharacterized conserved protein Function unknown 116620698 Common - RND efflux system, outer membrane lipoprotein, NodT family Acid_1578 117 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 116622184 Common - 4'-phosphopantetheinyl transferase Acid_3076 9 COG2091 Sfp, Phosphopantetheinyl transferase Coenzyme metabolism 116622274 Nonpathogen - 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family-like protein Acid_3168 4 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 116621907 Common - PAS/PAC sensor signal transduction histidine kinase Acid_2792 185 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 116621426 Common - transcriptional regulator, PadR-like family Acid_2308 57 COG1695 COG1695, Predicted transcriptional regulators Transcription 116625683 Common - hypothetical protein Acid_6632 31 None None None 116623157 Common - Acetamidase/Formamidase Acid_4063 58 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 116625441 Common - amidohydrolase 2 Acid_6386 4 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 116626001 Nonpathogen - hypothetical protein Acid_6959 1 None None None 116623991 Nonpathogen - protein of unknown function DUF214 Acid_4903 7 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 116626109 Common - X-Pro dipeptidyl-peptidase C-terminal domain protein Acid_7067 57 COG2936 COG2936, Predicted acyl esterases General function prediction only 116621957 Nonpathogen - hypothetical protein Acid_2842 1 None None None 116621918 Common - response regulator receiver protein Acid_2803 205 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 116624578 Nonpathogen - hypothetical protein Acid_5502 1 None None None 116620071 Common - transposase IS3/IS911 family protein Acid_0943 51 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 116623702 Common - GCN5-related N-acetyltransferase Acid_4614 121 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 116623309 Nonpathogen - hypothetical protein Acid_4216 1 None None None 116621593 Common - protein of unknown function DUF6, transmembrane Acid_2475 131 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 116624368 Common - 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase Acid_5289 126 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 116626758 Common thiG thiazole synthase Acid_7731 166 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 116620243 Common - amidohydrolase Acid_1120 17 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 116622787 Common - dehydrogenase, E1 component Acid_3687 201 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 116619980 Nonpathogen - hypothetical protein Acid_0852 3 None None None 116625781 Common - transcriptional regulator, TetR family Acid_6731 107 COG1309 AcrR, Transcriptional regulator Transcription 116619752 Common - hypothetical protein Acid_0618 2 None None None 116622989 Common - conserved hypothetical protein, transmembrane prediction Acid_3892 8 None None None 116620212 Common - histone deacetylase superfamily Acid_1085 158 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 116624838 Common - iron-sulfur cluster binding protein Acid_5762 94 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 116620257 Common - glycosyl hydrolase, family 88 Acid_1134 13 None None None 116626749 Nonpathogen - hypothetical protein Acid_7722 1 None None None 116622360 Common - peptidase M48, Ste24p Acid_3254 133 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 116622695 Common - hypothetical protein Acid_3594 22 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 116621434 Nonpathogen - hypothetical protein Acid_2316 3 COG4548 NorD, Nitric oxide reductase activation protein Inorganic ion transport and metabolism 116619787 Common - Transketolase, central region Acid_0657 152 COG3958 COG3958, Transketolase, C-terminal subunit Carbohydrate transport and metabolism 116621424 Nonpathogen - hypothetical protein Acid_2306 1 None None None 116625897 Common - serine/threonine protein kinase Acid_6852 164 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 116622126 Common - hypothetical protein Acid_3014 12 COG4641 COG4641, Uncharacterized protein conserved in bacteria Function unknown 116625890 Common - putative transposase Acid_6844 37 None None None 116621880 Common - Ig family protein Acid_2763 41 None None None 116621329 Nonpathogen - hypothetical protein Acid_2210 2 None None None 116620690 Common - protein of unknown function DUF329 Acid_1570 60 COG3024 COG3024, Uncharacterized protein conserved in bacteria Function unknown 116626917 Nonpathogen - cytochrome c, class I Acid_7894 1 None None None 116623022 Common - uncharacterized enzyme Acid_3926 68 COG2170 COG2170, Uncharacterized conserved protein Function unknown 116623481 Common - protein of unknown function DUF893, YccS/YhfK Acid_4391 39 COG1289 COG1289, Predicted membrane protein Function unknown 116621851 Common - TonB-dependent receptor Acid_2734 23 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 116626853 Common - inner-membrane translocator Acid_7826 131 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 116625580 Nonpathogen - hypothetical protein Acid_6529 1 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 116626039 Common - ErfK/YbiS/YcfS/YnhG Acid_6997 66 COG3034 COG3034, Uncharacterized protein conserved in bacteria Function unknown 116625487 Nonpathogen - hypothetical protein Acid_6433 8 None None None 116621413 Common - peptidase M20 Acid_2295 82 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 116619977 Common - NUDIX hydrolase Acid_0849 189 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 116623496 Common - Xylose isomerase domain protein TIM barrel Acid_4406 14 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 116623623 Common - Pyrrolo-quinoline quinone Acid_4533 127 COG1520 COG1520, FOG: WD40-like repeat Function unknown