Shewanella frigidimarina NCIMB 400, complete genome NC_008345 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 114563074 Common - Mannitol dehydrogenase, C-terminal domain protein Sfri_1903 90 COG0246 MtlD, Mannitol-1-phosphate/altronate dehydrogenases Carbohydrate transport and metabolism 114565171 Common - phosphoglyceromutase Sfri_4021 125 COG0696 GpmI, Phosphoglyceromutase Carbohydrate transport and metabolism 114564975 Common - N-acetylglutamate synthase Sfri_3825 206 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 114563611 Common - NADH:flavin oxidoreductase/NADH oxidase Sfri_2441 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 114564750 Common - luciferase family protein Sfri_3598 109 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 114563866 Common yajC preprotein translocase subunit YajC Sfri_2701 174 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 114562420 Common - hypothetical protein Sfri_1242 6 None None None 114563808 Common - Glycerate kinase Sfri_2642 81 COG1929 COG1929, Glycerate kinase Carbohydrate transport and metabolism 114563968 Common - MscS Mechanosensitive ion channel Sfri_2803 200 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 114562015 Common - TonB-dependent receptor Sfri_0837 106 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 114561232 Common - hypothetical protein Sfri_0044 2 None None None 114561713 Common - hypothetical protein Sfri_0527 8 None None None 114562425 Common - transcriptional regulator, LysR family protein Sfri_1247 148 COG0583 LysR, Transcriptional regulator Transcription 114563731 Common - hypothetical protein Sfri_2565 25 None None None 114563755 Common - protein of unknown function DUF819 Sfri_2589 20 COG5505 COG5505, Predicted integral membrane protein Function unknown 114564789 Nonpathogen - hypothetical protein Sfri_3637 2 None None None 114562329 Common - protein of unknown function DUF400 Sfri_1151 16 COG3018 COG3018, Uncharacterized protein conserved in bacteria Function unknown 114563782 Common - ferrous iron transport protein B Sfri_2616 185 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 114562630 Common upp uracil phosphoribosyltransferase Sfri_1453 164 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 114564335 Common - GCN5-related N-acetyltransferase Sfri_3174 15 COG0456 RimI, Acetyltransferases General function prediction only 114562467 Common - transposase IS116/IS110/IS902 family protein Sfri_1289 43 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 114561642 Common prmA ribosomal protein L11 methyltransferase Sfri_0455 174 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 114565154 Common - transcriptional regulator, ArsR family protein Sfri_4004 146 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 114563713 Common - protein of unknown function UPF0153 Sfri_2546 12 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 114562880 Common - hypothetical protein Sfri_1705 7 None None None 114563098 Common - diguanylate cyclase Sfri_1927 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 114563794 Common - TonB-dependent receptor Sfri_2628 102 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 114563994 Common - dTDP-glucose 4,6-dehydratase Sfri_2830 231 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 114562858 Nonpathogen - hypothetical protein Sfri_1682 1 None None None 114564075 Common - cytochrome B561 Sfri_2911 44 COG3658 COG3658, Cytochrome b Energy production and conversion 114562992 Common - glycine betaine/L-proline ABC transporter, ATPase subunit Sfri_1817 249 COG4175 ProV, ABC-type proline/glycine betaine transport system, ATPase component Amino acid transport and metabolism 114562851 Common - phage terminase GpA Sfri_1675 37 COG5525 COG5525, Bacteriophage tail assembly protein General function prediction only 114563334 Common - glycogen/starch/alpha-glucan phosphorylases Sfri_2163 138 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 114562269 Common - hypothetical protein Sfri_1091 9 None None None 114561955 Common - zinc carboxypeptidase-related protein Sfri_0774 16 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 114565045 Common - hypothetical protein Sfri_3895 1 None None None 114561319 Common - UDP-N-acetylenolpyruvoylglucosamine reductase Sfri_0131 177 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 114562337 Common - response regulator receiver modulated CheW protein Sfri_1159 199 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 114563338 Common - NUDIX hydrolase Sfri_2167 129 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 114562317 Common - CMP/dCMP deaminase, zinc-binding Sfri_1139 214 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 114561679 Common - phosphoribosylamine--glycine ligase Sfri_0492 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 114563121 Common - phage integrase family protein Sfri_1950 48 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 114561386 Common - diguanylate cyclase Sfri_0198 177 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 114564307 Common - Integrase, catalytic region Sfri_3145 143 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 114563674 Common - response regulator receiver modulated metal dependent phosphohydrolase Sfri_2505 225 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 114561901 Common - Patatin Sfri_0718 33 COG4667 COG4667, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 114564377 Common - ATP-dependent RNA helicase DbpA Sfri_3216 229 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 114561953 Common - carbon starvation protein CstA Sfri_0772 109 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 114565095 Common - cytochrome c, class I Sfri_3945 57 COG2863 COG2863, Cytochrome c553 Energy production and conversion 114562514 Common - homoserine O-succinyltransferase Sfri_1336 64 COG1897 MetA, Homoserine trans-succinylase Amino acid transport and metabolism 162139116 Common - cysteine/glutathione ABC transporter membrane/ATP-binding component Sfri_3212 249 COG4987 CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 114563929 Common - Glutathione peroxidase Sfri_2764 114 COG0386 BtuE, Glutathione peroxidase Posttranslational modification, protein turnover, chaperones 114564264 Common - GntR domain protein Sfri_3102 143 COG2186 FadR, Transcriptional regulators Transcription 114562238 Common - RNA polymerase, sigma 28 subunit Sfri_1060 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 114563632 Common - cell division protein ZipA Sfri_2462 41 COG3115 ZipA, Cell division protein Cell division and chromosome partitioning 114562681 Common - molybdopterin oxidoreductase Sfri_1505 187 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 114561908 Common - Invasion gene expression up-regulator, SirB Sfri_0725 36 COG3094 COG3094, Uncharacterized protein conserved in bacteria Function unknown 114562999 Common - Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B Sfri_1824 86 COG3384 COG3384, Uncharacterized conserved protein Function unknown 114564033 Common - hypothetical protein Sfri_2869 6 None None None 114564801 Common - flavin-containing monooxygenase FMO Sfri_3649 81 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 114562728 Common - D,D-heptose 1,7-bisphosphate phosphatase Sfri_1552 128 COG0241 HisB, Histidinol phosphatase and related phosphatases Amino acid transport and metabolism 114561666 Common - phosphoesterase, PA-phosphatase related Sfri_0479 77 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 114564321 Common - O-acetylhomoserine/O-acetylserine sulfhydrylase Sfri_3160 206 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 114564667 Common - 1-acyl-sn-glycerol-3-phosphate acyltransferases Sfri_3514 141 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 114561974 Common - transcriptional regulator, LysR family protein Sfri_0794 139 COG0583 LysR, Transcriptional regulator Transcription 114563133 Common - protein of unknown function DUF140 Sfri_1962 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 114564512 Common rpsF 30S ribosomal protein S6 Sfri_3351 190 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 114561672 Common - two component transcriptional regulator, winged helix family protein Sfri_0485 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114564276 Common - major facilitator superfamily MFS_1 Sfri_3114 108 None None None 114562364 Common - flagellar export protein FliJ Sfri_1186 37 COG2882 FliJ, Flagellar biosynthesis chaperone Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 114561968 Common - prolipoprotein diacylglyceryl transferase Sfri_0788 196 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 114563322 Common - protein of unknown function DUF885 Sfri_2151 41 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 114563125 Common - restriction modification system DNA specificity domain Sfri_1954 86 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 114564992 Common - type III restriction enzyme, res subunit Sfri_3842 142 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 114563463 Nonpathogen - protein of unknown function DUF125, transmembrane Sfri_2292 9 None None None 114562650 Common - chromosome replication initiation inhibitor protein Sfri_1473 85 COG0583 LysR, Transcriptional regulator Transcription 114563572 Common - L-serine dehydratase 1 Sfri_2402 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 114562315 Common - inositol-5-monophosphate dehydrogenase Sfri_1137 237 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 114562383 Common - Cobyrinic acid a,c-diamide synthase Sfri_1205 227 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 114561735 Common - diguanylate cyclase Sfri_0549 180 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114561280 Common - pseudouridine synthase Rlu family protein, TIGR01621 Sfri_0092 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 114564562 Common - protein of unknown function DUF107 Sfri_3401 3 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 114564879 Common - hypothetical protein Sfri_3727 75 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 114562310 Common - two component transcriptional regulator, winged helix family protein Sfri_1132 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114563700 Common - transglutaminase domain protein Sfri_2532 85 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 114563564 Common - GCN5-related N-acetyltransferase Sfri_2394 86 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 114562828 Nonpathogen - hypothetical protein Sfri_1652 1 None None None 114562373 Common flhB flagellar biosynthesis protein FlhB Sfri_1195 130 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 114563253 Common - hypothetical protein Sfri_2082 4 None None None 114562658 Common - hypothetical protein Sfri_1481 23 COG3085 COG3085, Uncharacterized protein conserved in bacteria Function unknown 114563169 Common - histidine kinase Sfri_1998 165 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 114565104 Common - transcriptional regulator, histidine utilization repressor, GntR family protein Sfri_3954 123 COG2188 PhnF, Transcriptional regulators Transcription 114564286 Common - 6-aminohexanoate-dimer hydrolase Sfri_3124 99 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 114563639 Common - transcriptional regulator, LysR family protein Sfri_2469 181 COG0583 LysR, Transcriptional regulator Transcription 114563852 Common - membrane protein involved in aromatic hydrocarbon degradation Sfri_2687 73 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 114563961 Common - DEAD/DEAH box helicase domain protein Sfri_2796 238 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 114561285 Common - molybdenum cofactor synthesis domain Sfri_0097 196 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 114563117 Common - choline dehydrogenase Sfri_1946 92 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 114564812 Common groEL chaperonin GroEL Sfri_3660 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 114563681 Common - Glutathione synthase Sfri_2513 2 None None None 114563106 Common - 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) Sfri_1935 157 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 114562059 Common - extracellular solute-binding protein, family 3 Sfri_0881 68 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 114563092 Common pssA phosphatidylserine synthase Sfri_1921 30 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 114564486 Common - DNA topoisomerase IV subunit A Sfri_3325 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 114564137 Common anmK anhydro-N-acetylmuramic acid kinase Sfri_2973 120 COG2377 COG2377, Predicted molecular chaperone distantly related to HSP70-fold metalloproteases Posttranslational modification, protein turnover, chaperones 114564592 Common - IstB domain protein ATP-binding protein Sfri_3434 100 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 114564028 Common - hypothetical protein Sfri_2864 13 None None None 114562479 Nonpathogen - putative orphan protein Sfri_1301 2 None None None 114561981 Common - amidohydrolase Sfri_0801 100 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 114564061 Common - amino acid carrier protein Sfri_2897 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 114562106 Common - hypothetical protein Sfri_0928 6 None None None 114561339 Common rplB 50S ribosomal protein L2 Sfri_0151 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 114562215 Common - 3,4-dihydroxy-2-butanone 4-phosphate synthase Sfri_1037 231 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 114563847 Common - TPR repeat-containing protein Sfri_2682 60 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 114565061 Common - globin Sfri_3911 26 COG2346 COG2346, Truncated hemoglobins General function prediction only 114562626 Common - hypothetical protein Sfri_1449 7 None None None 114562303 Common - lipoprotein, putative Sfri_1125 3 None None None 114564870 Common - Endonuclease/exonuclease/phosphatase Sfri_3718 49 COG2374 COG2374, Predicted extracellular nuclease General function prediction only 114564474 Common - DNA mismatch repair protein MutL Sfri_3313 191 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 114563449 Common - NUDIX hydrolase Sfri_2278 33 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 114561243 Common - cytoplasmic chaperone TorD family protein Sfri_0055 30 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 114561986 Common - Glutathione S-transferase, N-terminal domain protein Sfri_0806 83 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 114564141 Common - hypothetical protein Sfri_2977 12 None None None 114564241 Common ksgA dimethyladenosine transferase Sfri_3079 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 114565106 Common - haloacid dehalogenase, type II Sfri_3956 88 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 114562761 Common - major facilitator superfamily MFS_1 Sfri_1585 104 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 114561525 Common - 3-oxoacyl-(acyl carrier protein) synthase II Sfri_0337 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 114561365 Common - heme exporter protein CcmC Sfri_0177 111 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 114562415 Common - hypothetical protein Sfri_1237 10 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 114562500 Common - protein of unknown function DUF218 Sfri_1322 76 COG1434 COG1434, Uncharacterized conserved protein Function unknown 114564855 Common - protein of unknown function DUF140 Sfri_3703 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 114564396 Common - UDP-N-acetylmuramate Sfri_3235 207 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 114562831 Common - phage integrase family protein Sfri_1655 41 COG0582 XerC, Integrase DNA replication, recombination, and repair 114561567 Common - hypothetical protein Sfri_0379 9 None None None 114563764 Common - Methylenetetrahydrofolate dehydrogenase (NADP(+)) Sfri_2598 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 114561607 Common - DNA-binding transcriptional regulator IlvY Sfri_0420 186 COG0583 LysR, Transcriptional regulator Transcription 114564962 Common mraW S-adenosyl-methyltransferase MraW Sfri_3812 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 114563029 Common - transcriptional regulator, GntR family protein Sfri_1856 136 COG1802 GntR, Transcriptional regulators Transcription 114563287 Common - hypothetical protein Sfri_2116 1 None None None 114563665 Nonpathogen - hypothetical protein Sfri_2495 3 None None None 114564221 Common - MltA-interacting MipA family protein Sfri_3058 29 COG3713 OmpV, Outer membrane protein V Cell envelope biogenesis, outer membrane 114564806 Nonpathogen - hypothetical protein Sfri_3654 2 None None None 114564607 Common - Integrase, catalytic region Sfri_3451 117 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 114563506 Common cpdB bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein Sfri_2335 109 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 114564830 Common - efflux transporter, RND family, MFP subunit Sfri_3678 138 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 114563201 Common - riboflavin synthase subunit alpha Sfri_2030 208 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 114561611 Common - dihydroxy-acid dehydratase Sfri_0424 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 114564569 Common - Inosine/uridine-preferring nucleoside hydrolase Sfri_3408 88 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 114562201 Common - putative signal transduction protein Sfri_1023 46 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 114564312 Common gcvT glycine cleavage system aminomethyltransferase T Sfri_3151 178 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 114562443 Common purU formyltetrahydrofolate deformylase Sfri_1265 220 COG0788 PurU, Formyltetrahydrofolate hydrolase Nucleotide transport and metabolism 114562639 Common - TolB, N-terminal domain protein Sfri_1462 156 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 114561539 Common - acyl carrier protein Sfri_0351 80 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 114563247 Nonpathogen - hypothetical protein Sfri_2076 4 None None None 114563354 Common - hypothetical protein Sfri_2183 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 114562706 Common - hypothetical protein Sfri_1530 10 None None None 114564462 Common - peptidase S9, prolyl oligopeptidase active site domain protein Sfri_3301 113 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 114563837 Common - peptidase M16 domain protein Sfri_2671 180 COG1025 Ptr, Secreted/periplasmic Zn-dependent peptidases, insulinase-like Posttranslational modification, protein turnover, chaperones 114561476 Common - hypothetical protein Sfri_0288 2 None None None 114562585 Common - Redoxin domain protein Sfri_1408 91 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 114564208 Common - peptidylprolyl isomerase, FKBP-type Sfri_3045 137 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 114564883 Common - peptidase U62, modulator of DNA gyrase Sfri_3731 170 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 114562800 Common - OmpA/MotB domain protein Sfri_1624 109 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 114562594 Common - hypothetical protein Sfri_1417 20 None None None 114563305 Common nrdB ribonucleotide-diphosphate reductase subunit beta Sfri_2134 154 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 114563149 Common - beta-lactamase domain protein Sfri_1978 181 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 114564868 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase Sfri_3716 114 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 114561763 Common - hypothetical protein Sfri_0577 2 None None None 114561946 Common - transcriptional regulator, TetR family protein Sfri_0765 94 COG1309 AcrR, Transcriptional regulator Transcription 114562179 Common - nucleoside-specific channel-forming protein, Tsx Sfri_1001 22 COG3248 Tsx, Nucleoside-binding outer membrane protein Cell envelope biogenesis, outer membrane 114563361 Common - alpha-L-glutamate ligase-like protein Sfri_2190 18 None None None 114563240 Common - acyl-CoA dehydrogenase domain protein Sfri_2069 148 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 114565135 Common - efflux transporter, RND family, MFP subunit Sfri_3985 152 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 114564909 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) Sfri_3757 199 COG0281 SfcA, Malic enzyme Energy production and conversion 114562696 Common - Curli production assembly/transport component CsgG Sfri_1520 19 COG1462 CsgG, Uncharacterized protein involved in formation of curli polymers Cell envelope biogenesis, outer membrane 114562395 Common - hypothetical protein Sfri_1217 4 None None None 114562937 Common - Carbonate dehydratase Sfri_1762 149 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 114562916 Common - Disulphide bond formation protein DsbB Sfri_1741 31 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 114563453 Common - multiple resistance and pH regulation protein F Sfri_2282 37 COG2212 MnhF, Multisubunit Na+/H+ antiporter, MnhF subunit Inorganic ion transport and metabolism 114563041 Common fadE acyl-CoA dehydrogenase Sfri_1869 146 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 114562275 Common - SmpA/OmlA domain protein Sfri_1097 60 COG2913 SmpA, Small protein A (tmRNA-binding) Translation, ribosomal structure and biogenesis 114565125 Common - ABC transporter related Sfri_3975 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 114563774 Common - N-6 DNA methylase Sfri_2608 158 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 114563642 Common - hypothetical protein Sfri_2472 9 None None None 114564984 Common folE GTP cyclohydrolase I Sfri_3834 175 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 114563818 Common - PTS system, glucose-specific IIBC subunit Sfri_2652 49 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 114563344 Common - electron transport complex protein RnfB Sfri_2173 120 COG2878 COG2878, Predicted NADH:ubiquinone oxidoreductase, subunit RnfB Energy production and conversion 114564677 Common - GumN family protein Sfri_3524 48 COG3735 COG3735, Uncharacterized protein conserved in bacteria Function unknown 114561273 Common - molybdopterin biosynthesis MoaE Sfri_0085 157 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 114561457 Common - hypothetical protein Sfri_0269 1 None None None 114562436 Nonpathogen - hypothetical protein Sfri_1258 2 None None None 114565009 Common - peptidase M28 Sfri_3859 24 COG2234 Iap, Predicted aminopeptidases General function prediction only 114562410 Common - hypothetical protein Sfri_1232 14 None None None 114562166 Common - protein of unknown function DUF150 Sfri_0988 182 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 114561306 Common - 3'(2'),5'-bisphosphate nucleotidase Sfri_0118 183 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 114562067 Common - ABC-1 domain protein Sfri_0889 184 COG0661 AarF, Predicted unusual protein kinase General function prediction only 114562551 Common - UDP-glucose 6-dehydrogenase Sfri_1373 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 114562099 Common - extracellular solute-binding protein, family 3 Sfri_0921 29 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 114564444 Common - hypothetical protein Sfri_3283 23 COG3529 COG3529, Predicted nucleic-acid-binding protein containing a Zn-ribbon domain General function prediction only 114564093 Common - Ribonuclease III Sfri_2929 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 114565178 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Sfri_4028 82 COG0348 NapH, Polyferredoxin Energy production and conversion 114561427 Common - periplasmic sensor signal transduction histidine kinase Sfri_0239 190 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114563036 Common - glycine cleavage system transcriptional repressor, putative Sfri_1863 38 COG2716 GcvR, Glycine cleavage system regulatory protein Amino acid transport and metabolism 114563895 Common - Carbamoyl-phosphate synthase L chain, ATP-binding Sfri_2730 232 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 114563978 Common - hypothetical protein Sfri_2814 15 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 114562050 Common metH B12-dependent methionine synthase Sfri_0872 178 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 114561220 Common - amidohydrolase Sfri_0032 77 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 114561360 Common rpsD 30S ribosomal protein S4 Sfri_0172 221 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 114561880 Common - lytic murein transglycosylase B Sfri_0697 102 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 114561889 Common - protein of unknown function DUF1451 Sfri_0706 21 None None None 114562710 Common - Glutathione S-transferase, N-terminal domain protein Sfri_1534 26 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 114563374 Common - hypothetical protein Sfri_2203 10 None None None 114563066 Common - keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase Sfri_1895 126 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 114564660 Common - PhoH family protein Sfri_3507 193 COG1875 COG1875, Predicted ATPase related to phosphate starvation-inducible protein PhoH Signal transduction mechanisms 114562785 Common - Integrase, catalytic region Sfri_1609 143 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 114563688 Common - hypothetical protein Sfri_2520 11 None None None 114561482 Nonpathogen - hypothetical protein Sfri_0294 1 None None None 114564760 Common - Oxidoreductase FAD-binding domain protein Sfri_3608 137 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 114562567 Common - FAD dependent oxidoreductase Sfri_1390 47 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 114564839 Nonpathogen - hypothetical protein Sfri_3687 1 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 114562838 Common - transposase IS116/IS110/IS902 family protein Sfri_1662 44 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 114564727 Nonpathogen - hypothetical protein Sfri_3575 1 None None None 114564765 Common - Peptidyl-dipeptidase Dcp Sfri_3613 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 114564319 Common - hypothetical protein Sfri_3158 3 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 114564148 Common - metal dependent phosphohydrolase Sfri_2984 181 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 114561583 Common - hypothetical protein Sfri_0395 26 COG3788 COG3788, Uncharacterized relative of glutathione S-transferase, MAPEG superfamily General function prediction only 114563195 Common - aromatic amino acid aminotransferase Sfri_2024 72 COG1448 TyrB, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 114563340 Common asnC asparaginyl-tRNA synthetase Sfri_2169 219 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 114563019 Common - transposase, IS4 family protein Sfri_1845 17 None None None 114563955 Common - 1-deoxy-D-xylulose-5-phosphate synthase Sfri_2790 228 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 114564040 Common - cytochrome B561 Sfri_2876 87 COG3038 CybB, Cytochrome B561 Energy production and conversion 114564085 Common - signal recognition particle protein Sfri_2921 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 114563729 Common - Pseudouridine synthase, Rsu Sfri_2562 203 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 114562947 Common - transcriptional regulator, LacI family protein Sfri_1772 126 COG1609 PurR, Transcriptional regulators Transcription 114563170 Common - Twin-arginine translocation pathway signal Sfri_1999 184 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 114563742 Common - phage shock protein C, PspC Sfri_2576 36 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 114564696 Common - hypothetical protein Sfri_3544 1 None None None 114564227 Common - MltA-interacting MipA family protein Sfri_3064 4 COG3713 OmpV, Outer membrane protein V Cell envelope biogenesis, outer membrane 114561767 Common - methyl-accepting chemotaxis sensory transducer Sfri_0581 153 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114563479 Nonpathogen - hypothetical protein Sfri_2308 1 None None None 114562507 Common phhB pterin-4-alpha-carbinolamine dehydratase Sfri_1329 87 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 114563523 Nonpathogen - hypothetical protein Sfri_2353 1 None None None 114561354 Common - ribosomal protein L30 Sfri_0166 161 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 114561595 Common - hypothetical protein Sfri_0408 4 None None None 114561401 Common - likely secreted protein containing plastocyanin domain Sfri_0213 16 COG4633 COG4633, Uncharacterized protein conserved in bacteria Function unknown 114561661 Common - protein of unknown function DUF1243 Sfri_0474 30 COG3165 COG3165, Uncharacterized protein conserved in bacteria Function unknown 114563082 Common - LexA regulated protein Sfri_1911 21 None None None 114561505 Common - biotin/lipoyl attachment domain-containing protein Sfri_0317 94 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 114563556 Common - protein of unknown function DUF343 Sfri_2386 95 COG2835 COG2835, Uncharacterized conserved protein Function unknown 114563876 Common - methylated-DNA--protein-cysteine methyltransferase Sfri_2711 169 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 114563608 Common - GTP cyclohydrolase II Sfri_2438 198 COG0807 RibA, GTP cyclohydrolase II Coenzyme metabolism 114563931 Common - phosphate binding protein Sfri_2766 114 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 114561290 Common hslO Hsp33-like chaperonin Sfri_0102 140 COG1281 COG1281, Disulfide bond chaperones of the HSP33 family Posttranslational modification, protein turnover, chaperones 114562075 Common - efflux transporter, RND family, MFP subunit Sfri_0897 86 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 114563724 Common - protein of unknown function UPF0118 Sfri_2557 189 COG0628 PerM, Predicted permease General function prediction only 114563416 Common - ATP-binding protein, Mrp/Nbp35 family protein Sfri_2245 235 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 114563529 Nonpathogen - hypothetical protein Sfri_2359 1 None None None 114562278 Common - diguanylate cyclase Sfri_1100 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114562907 Common - alpha/beta hydrolase fold Sfri_1732 64 COG2267 PldB, Lysophospholipase Lipid metabolism 114561212 Common - peptide deformylase Sfri_0024 215 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 114562243 Nonpathogen - sodium pump decarboxylases, gamma subunit Sfri_1065 1 COG3630 OadG, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, gamma subunit Energy production and conversion 114562076 Common - ABC transporter related Sfri_0898 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 114564533 Common - KpsF/GutQ family protein Sfri_3372 166 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 114561826 Common - protein of unknown function DUF306, Meta and HslJ Sfri_0641 12 COG3187 HslJ, Heat shock protein Posttranslational modification, protein turnover, chaperones 114562135 Common - bacterioferritin Sfri_0957 100 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 114564847 Common - regulatory protein GntR, HTH Sfri_3695 137 COG2186 FadR, Transcriptional regulators Transcription 114563597 Common - RNA methyltransferase, TrmH family, group 1 Sfri_2427 172 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 114561328 Common - ribosomal protein L7/L12 Sfri_0140 211 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 114562741 Common - transcriptional regulator, MerR family protein Sfri_1565 102 COG0789 SoxR, Predicted transcriptional regulators Transcription 114563401 Common - putative GAF sensor protein Sfri_2230 80 COG1956 COG1956, GAF domain-containing protein Signal transduction mechanisms 114565209 Common - Alcohol dehydrogenase, zinc-binding domain protein Sfri_4059 206 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 114562080 Common - periplasmic sensor signal transduction histidine kinase Sfri_0902 216 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 114563048 Common - exsB protein Sfri_1876 175 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 114563936 Common - Glutathione S-transferase, N-terminal domain protein Sfri_2771 17 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 114561717 Common - fructose-1,6-bisphosphatase Sfri_0531 108 COG0158 Fbp, Fructose-1,6-bisphosphatase Carbohydrate transport and metabolism 114563497 Common - homogentisate 1,2-dioxygenase Sfri_2326 51 COG3508 HmgA, Homogentisate 1,2-dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 114561222 Common - shikimate 5-dehydrogenase Sfri_0034 212 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 114564821 Common - Aldose 1-epimerase Sfri_3669 93 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 114561963 Common - transcriptional regulator, LysR family protein Sfri_0783 148 COG0583 LysR, Transcriptional regulator Transcription 114564589 Common - glutamate--cysteine ligase Sfri_3430 58 COG2918 GshA, Gamma-glutamylcysteine synthetase Coenzyme metabolism 114562290 Common - protein of unknown function DUF21 Sfri_1112 219 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 114564224 Common - periplasmic sensor signal transduction histidine kinase Sfri_3061 216 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114562183 Common deoD purine nucleoside phosphorylase Sfri_1005 94 COG0813 DeoD, Purine-nucleoside phosphorylase Nucleotide transport and metabolism 114561403 Common - Redoxin domain protein Sfri_0215 82 COG0678 AHP1, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 114562772 Common - putative acetyltransferase Sfri_1596 24 None None None 114564216 Common - F0F1 ATP synthase subunit A Sfri_3053 199 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 114561999 Common - heat shock protein DnaJ domain protein Sfri_0819 56 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 114565037 Common - heavy metal efflux pump, CzcA family protein Sfri_3887 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 114565215 Common - ribonuclease P protein component Sfri_4065 74 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 114565141 Common - transcriptional regulator, LacI family protein Sfri_3991 122 COG1609 PurR, Transcriptional regulators Transcription 114563943 Common - peptidase S9, prolyl oligopeptidase active site domain protein Sfri_2778 101 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 114561507 Common - dehydrogenase, E1 component Sfri_0319 154 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 114564685 Common - hypothetical protein Sfri_3533 37 None None None 114563435 Common - hypothetical protein Sfri_2264 3 None None None 114564194 Common - Cyclopropane-fatty-acyl-phospholipid synthase Sfri_3031 127 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 114561753 Common - SH3, type 3 domain protein Sfri_0567 33 COG3103 COG3103, SH3 domain protein Signal transduction mechanisms 114564959 Common - UDP-N-acetylmuramyl-tripeptide synthetases Sfri_3809 213 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 114561393 Common - Pirin domain protein domain protein Sfri_0205 141 COG1741 COG1741, Pirin-related protein General function prediction only 114561681 Common zntR zinc-responsive transcriptional regulator Sfri_0494 144 COG0789 SoxR, Predicted transcriptional regulators Transcription 114561749 Common - Catalase Sfri_0563 126 COG0753 KatE, Catalase Inorganic ion transport and metabolism 114565030 Nonpathogen - hypothetical protein Sfri_3880 2 None None None 114563206 Common - hypothetical protein Sfri_2035 6 None None None 114563649 Common - succinylarginine dihydrolase Sfri_2479 34 COG3724 AstB, Succinylarginine dihydrolase Amino acid transport and metabolism 114564244 Common - methyl-accepting chemotaxis sensory transducer Sfri_3082 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114562110 Common - hypothetical protein Sfri_0932 16 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 114565192 Common - TonB-dependent siderophore receptor Sfri_4042 114 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 114561549 Common - AMP-dependent synthetase and ligase Sfri_0361 220 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 114562409 Nonpathogen - helix-turn-helix, AraC type Sfri_1231 6 None None None 114565200 Common - ATP synthase F0, C subunit Sfri_4050 74 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 114561270 Common moaA molybdenum cofactor biosynthesis protein A Sfri_0082 205 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 114565019 Nonpathogen - hypothetical protein Sfri_3869 4 COG1073 COG1073, Hydrolases of the alpha/beta superfamily General function prediction only 114563948 Common - DNA-binding transcriptional activator GcvA Sfri_2783 186 COG0583 LysR, Transcriptional regulator Transcription 114561813 Common - phospho-2-dehydro-3-heoxyheptonate aldolase Sfri_0628 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 114561882 Common - Peptidoglycan glycosyltransferase Sfri_0699 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 114562197 Common - PAS/PAC sensor hybrid histidine kinase Sfri_1019 224 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114561912 Common - hypothetical protein Sfri_0729 25 None None None 114563408 Common - hydrolase, TatD family protein Sfri_2237 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 114562208 Common - efflux transporter, RND family, MFP subunit Sfri_1030 157 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 114561971 Common - UspA domain protein Sfri_0791 68 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 114564350 Common - Phospholipase A(1) Sfri_3189 52 COG2829 PldA, Outer membrane phospholipase A Cell envelope biogenesis, outer membrane 114561455 Common - efflux transporter, RND family, MFP subunit Sfri_0267 146 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 114564545 Common - response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Sfri_3384 223 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114564193 Common - hypothetical protein Sfri_3030 16 None None None 114563022 Common - protein of unknown function UPF0061 Sfri_1849 110 COG0397 COG0397, Uncharacterized conserved protein Function unknown 114561471 Common - putative signal transduction protein Sfri_0283 63 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 114565051 Common - two component transcriptional regulator, winged helix family protein Sfri_3901 212 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114564177 Common - FAD dependent oxidoreductase Sfri_3014 119 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 114561851 Common - putative lipoprotein Sfri_0666 124 COG4105 ComL, DNA uptake lipoprotein General function prediction only 114565184 Common - FMN-binding domain protein Sfri_4034 7 None None None 114562965 Common - Fmu (Sun) domain protein Sfri_1790 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 114561464 Common - cell division ATP-binding protein FtsE Sfri_0276 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 114564642 Common - MerC mercury resistance protein Sfri_3489 9 None None None 114563136 Common - hypothetical protein Sfri_1965 1 None None None 114562152 Common - Dihydrodipicolinate reductase Sfri_0974 217 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 114564231 Common - DEAD/DEAH box helicase domain protein Sfri_3068 241 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 114561873 Common - hypothetical protein Sfri_0690 1 None None None 114564002 Common - acylneuraminate cytidylyltransferase Sfri_2838 52 COG1083 NeuA, CMP-N-acetylneuraminic acid synthetase Cell envelope biogenesis, outer membrane 114564380 Common - methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor Sfri_3219 154 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114562734 Common - ISSod10, transposase OrfA Sfri_1558 27 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 114561941 Common - NUDIX hydrolase Sfri_0760 17 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 114561613 Common - Alanine--glyoxylate transaminase Sfri_0426 158 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 114564131 Common - CobD-related protein Sfri_2967 29 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 114561468 Common - O-succinylbenzoate synthase Sfri_0280 58 COG1441 MenC, O-succinylbenzoate synthase Coenzyme metabolism 114561540 Common - hypothetical protein Sfri_0352 46 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 114563430 Common - NUDIX hydrolase Sfri_2259 50 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 114564498 Common - hypothetical protein Sfri_3337 1 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 114563871 Common - pseudouridine synthase Sfri_2706 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 114561197 Common - amidohydrolase Sfri_0009 162 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 114561519 Common rbn ribonuclease BN Sfri_0331 166 COG1295 Rbn, Predicted membrane protein Function unknown 114563618 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sfri_2448 11 COG3565 COG3565, Predicted dioxygenase of extradiol dioxygenase family General function prediction only 114563667 Common - Ankyrin Sfri_2498 116 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 114562481 Common - glucosyltransferase MdoH Sfri_1303 60 COG2943 MdoH, Membrane glycosyltransferase Cell envelope biogenesis, outer membrane 114564610 Nonpathogen - hypothetical protein Sfri_3454 1 None None None 114565148 Common - hypothetical protein Sfri_3998 124 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 114562434 Common - hypothetical protein Sfri_1256 21 COG4323 COG4323, Predicted membrane protein Function unknown 114561802 Common - transcriptional regulator, LysR family protein Sfri_0617 1 COG0583 LysR, Transcriptional regulator Transcription 114565097 Common - hypothetical protein Sfri_3947 22 COG3078 COG3078, Uncharacterized protein conserved in bacteria Function unknown 114564755 Common - porin, Gram-negative type Sfri_3603 19 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 114562853 Common - phage portal protein, lambda family protein Sfri_1677 34 COG5511 COG5511, Bacteriophage capsid protein General function prediction only 114562281 Common - putative signal transduction protein Sfri_1103 43 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 114561263 Common - hypothetical protein Sfri_0075 16 COG3097 COG3097, Uncharacterized protein conserved in bacteria Function unknown 114563534 Common - protein of unknown function DUF879 Sfri_2364 48 COG3519 COG3519, Uncharacterized protein conserved in bacteria Function unknown 114564485 Common - BFD domain protein (2Fe-2S)-binding domain protein Sfri_3324 30 COG2906 Bfd, Bacterioferritin-associated ferredoxin Inorganic ion transport and metabolism 114564168 Common - FAD dependent oxidoreductase Sfri_3005 128 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 114564479 Common - ribosome-associated GTPase Sfri_3318 163 COG1162 COG1162, Predicted GTPases General function prediction only 114562717 Common - Inosine kinase Sfri_1541 60 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 114563234 Common - acetyl-CoA acetyltransferases Sfri_2063 168 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 114561605 Common - Mg chelatase, subunit ChlI Sfri_0418 201 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 114564124 Common - binding-protein-dependent transport systems inner membrane component Sfri_2960 116 COG4135 COG4135, ABC-type uncharacterized transport system, permease component General function prediction only 114563473 Common - putative phosphohistidine phosphatase, SixA Sfri_2302 8 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 114564295 Common - hypothetical protein Sfri_3133 3 None None None 114563251 Common - 6-phosphogluconate dehydrogenase, NAD-binding Sfri_2080 194 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 114562045 Common - thioredoxin Sfri_0867 231 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 114561199 Common - SirA family protein Sfri_0011 83 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 114563123 Common - hypothetical protein Sfri_1952 5 None None None 114564114 Common - conserved hypothetical radical SAM protein Sfri_2950 94 COG1242 COG1242, Predicted Fe-S oxidoreductase General function prediction only 114561417 Common - fumarate lyase Sfri_0229 238 COG0114 FumC, Fumarase Energy production and conversion 114563315 Common - NADH:flavin oxidoreductase/NADH oxidase Sfri_2144 200 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 114562896 Common - diguanylate cyclase with PAS/PAC sensor Sfri_1721 184 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114563625 Common - hypothetical protein Sfri_2455 2 None None None 114562562 Common - hypothetical protein Sfri_1385 158 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 114563637 Common - 3-oxoacyl-(acyl carrier protein) synthase III Sfri_2467 197 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 114561805 Common - two component transcriptional regulator, LuxR family protein Sfri_0620 221 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 114563157 Common - diguanylate cyclase Sfri_1986 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114565122 Common - hypothetical protein Sfri_3972 7 None None None 114565216 Common rpmH 50S ribosomal protein L34 Sfri_4066 12 None None None 114563215 Common - Bile acid:sodium symporter Sfri_2044 91 COG0385 COG0385, Predicted Na+-dependent transporter General function prediction only 114562931 Common - SirA family protein Sfri_1756 3 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 114561512 Common - GTP-binding protein TypA Sfri_0324 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 114562494 Common - Beta-glucosidase Sfri_1316 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 114564775 Common - protein of unknown function DUF1449 Sfri_3623 14 None None None 114562815 Common - phage integrase family protein Sfri_1639 101 COG0582 XerC, Integrase DNA replication, recombination, and repair 114564717 Common - TRAP transporter, 4TM/12TM fusion protein Sfri_3565 134 COG4666 COG4666, TRAP-type uncharacterized transport system, fused permease components General function prediction only 114563000 Common - transcriptional regulator, LysR family protein Sfri_1825 167 COG0583 LysR, Transcriptional regulator Transcription 114564584 Common - small multidrug resistance protein Sfri_3425 137 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 114563519 Common gltA type II citrate synthase Sfri_2348 194 COG0372 GltA, Citrate synthase Energy production and conversion 114562671 Common rpmF 50S ribosomal protein L32 Sfri_1495 66 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 114562848 Nonpathogen - hypothetical protein Sfri_1672 1 None None None 114561740 Common - hypothetical protein Sfri_0554 50 COG5621 COG5621, Predicted secreted hydrolase General function prediction only 114563913 Common - electron transfer flavoprotein beta-subunit Sfri_2748 153 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 114563490 Common - anti-ECFsigma factor, ChrR Sfri_2319 28 COG3806 ChrR, Transcriptional activator Transcription 114563153 Common - Peroxidase Sfri_1982 226 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 114563827 Common - putative RNA methylase Sfri_2661 168 COG0116 COG0116, Predicted N6-adenine-specific DNA methylase DNA replication, recombination, and repair 114561295 Common - general secretion pathway protein F Sfri_0107 142 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 114563793 Common - Methyltransferase type 11 Sfri_2627 9 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 114562624 Common - ATP-dependent helicase HrpA Sfri_1447 132 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 114561312 Common - DNA-binding transcriptional repressor FabR Sfri_0124 56 COG1309 AcrR, Transcriptional regulator Transcription 114565132 Common mogA molybdenum cofactor biosynthesis protein Sfri_3982 190 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 114563079 Common - elongation factor P Sfri_1908 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 114564235 Common djlA Dna-J like membrane chaperone protein Sfri_3073 78 COG1076 DjlA, DnaJ-domain-containing proteins 1 Posttranslational modification, protein turnover, chaperones 114561837 Common - protein of unknown function DUF481 Sfri_0652 37 COG3137 COG3137, Putative salt-induced outer membrane protein Cell envelope biogenesis, outer membrane 114565118 Common - thioesterase superfamily protein Sfri_3968 58 COG0824 FcbC, Predicted thioesterase General function prediction only 114564810 Common - protein of unknown function DUF88 Sfri_3658 76 COG1432 COG1432, Uncharacterized conserved protein Function unknown 114561405 Common envZ osmolarity sensor protein Sfri_0217 215 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114564542 Common - phosphocarrier, HPr family protein Sfri_3381 91 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 114561983 Common - transcriptional regulator, MarR family protein Sfri_0803 114 COG1846 MarR, Transcriptional regulators Transcription 114562397 Common - Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ Sfri_1219 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 114561698 Nonpathogen - hypothetical protein Sfri_0512 3 None None None 114561737 Common - transcriptional regulator, LysR family protein Sfri_0551 187 COG0583 LysR, Transcriptional regulator Transcription 114564537 Common - ABC transporter related Sfri_3376 249 COG1137 YhbG, ABC-type (unclassified) transport system, ATPase component General function prediction only 114561914 Common - VanZ family protein Sfri_0731 8 COG5652 COG5652, Predicted integral membrane protein Function unknown 114564823 Common - hypothetical protein Sfri_3671 1 None None None 114563113 Common - glyceraldehyde-3-phosphate dehydrogenase Sfri_1942 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 114564009 Common - hypothetical protein Sfri_2845 23 None None None 114564935 Common - type IV-A pilus assembly ATPase PilB Sfri_3783 223 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 114563908 Common - Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter MnhD subunit-like protein Sfri_2743 55 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 114564528 Common - toluene tolerance family protein Sfri_3367 69 COG2854 Ttg2D, ABC-type transport system involved in resistance to organic solvents, auxiliary component Secondary metabolites biosynthesis, transport, and catabolism 114564360 Common - hypothetical protein Sfri_3199 1 None None None 114561431 Common - competence protein ComF Sfri_0243 123 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 114561840 Common - hypothetical protein Sfri_0655 8 None None None 114563543 Common - ImcF domain protein Sfri_2373 47 COG3523 IcmF, Uncharacterized protein conserved in bacteria Function unknown 114564011 Common - hypothetical protein Sfri_2847 34 None None None 114561933 Common - hypothetical protein Sfri_0751 2 None None None 114562450 Common pyrH uridylate kinase Sfri_1272 233 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 114563885 Common - major facilitator superfamily MFS_1 Sfri_2720 185 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 114564015 Common - translation initiation factor Sui1 Sfri_2851 47 COG0023 SUI1, Translation initiation factor 1 (eIF-1/SUI1) and related proteins Translation, ribosomal structure and biogenesis 114562264 Common - hypothetical protein Sfri_1086 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 114562588 Common - beta-lactamase domain protein Sfri_1411 218 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 114563890 Common - AMP-dependent synthetase and ligase Sfri_2725 218 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 114562723 Common - Na+/solute symporter Sfri_1547 166 COG4147 DhlC, Predicted symporter General function prediction only 114563396 Common - protein of unknown function DUF1302 Sfri_2225 18 None None None 114562869 Common - cold-shock DNA-binding domain protein Sfri_1693 182 COG1278 CspC, Cold shock proteins Transcription 114563059 Common - transcriptional regulator, TetR family protein Sfri_1888 75 COG1309 AcrR, Transcriptional regulator Transcription 114561730 Common - Deoxyribonuclease I Sfri_0544 32 COG2356 EndA, Endonuclease I DNA replication, recombination, and repair 114562253 Common - phosphoribosylaminoimidazole carboxylase ATPase subunit Sfri_1075 191 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 114562983 Common - methyl-accepting chemotaxis sensory transducer Sfri_1808 111 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114561554 Common - hypothetical protein Sfri_0366 2 COG3152 COG3152, Predicted membrane protein Function unknown 114562688 Common - serine/threonine protein kinase Sfri_1512 145 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 114564844 Common - outer membrane porin Sfri_3692 5 None None None 114564527 Common - SpoIIAA family protein Sfri_3366 6 COG3113 COG3113, Predicted NTP binding protein (contains STAS domain) General function prediction only 114563661 Common - nucleoid-associated protein NdpA Sfri_2491 31 COG3081 COG3081, Nucleoid-associated protein General function prediction only 114564770 Common - hypothetical protein Sfri_3618 5 None None None 114561570 Common - phosphoglycolate phosphatase Sfri_0382 191 COG0546 Gph, Predicted phosphatases General function prediction only 114563329 Common - Glutathione S-transferase, N-terminal domain protein Sfri_2158 99 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 114563272 Nonpathogen - hypothetical protein Sfri_2101 1 None None None 114563904 Nonpathogen - hypothetical protein Sfri_2739 6 COG2111 MnhB, Multisubunit Na+/H+ antiporter, MnhB subunit Inorganic ion transport and metabolism 114564249 Common obgE GTPase ObgE Sfri_3087 219 COG0536 Obg, Predicted GTPase General function prediction only 114562536 Common - phosphate ABC transporter, inner membrane subunit PstA Sfri_1358 224 COG4985 COG4985, ABC-type phosphate transport system, auxiliary component Inorganic ion transport and metabolism 114563690 Common - peptidase M56, BlaR1 Sfri_2522 8 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 114562117 Common - protein of unknown function DUF924 Sfri_0939 63 COG3803 COG3803, Uncharacterized protein conserved in bacteria Function unknown 114563444 Common - putative nitrogen regulatory protein P-II Sfri_2273 13 None None None 114565109 Common - GCN5-related N-acetyltransferase Sfri_3959 45 COG0456 RimI, Acetyltransferases General function prediction only 114562347 Common flgJ peptidoglycan hydrolase Sfri_1169 74 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 114562679 Common - 2-hydroxy-3-oxopropionate reductase Sfri_1503 193 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 114561715 Common - sodium:dicarboxylate symporter Sfri_0529 162 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 114561572 Common - transcriptional regulator, LysR family protein Sfri_0384 130 COG0583 LysR, Transcriptional regulator Transcription 114562642 Common - hypothetical protein Sfri_1465 22 None None None 114564570 Nonpathogen - hypothetical protein Sfri_3409 3 None None None 114561653 Common - delta-aminolevulinic acid dehydratase Sfri_0466 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 114564623 Common - cation diffusion facilitator family transporter Sfri_3467 191 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 114564349 Common - uroporphyrin-III C-methyltransferase Sfri_3188 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 114562225 Common - hybrid sensory histidine kinase BarA Sfri_1047 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114563108 Common - dihydrolipoamide acetyltransferase Sfri_1937 194 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 114563429 Common - Pseudouridine synthase, Rsu Sfri_2258 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 114564946 Common - preprotein translocase subunit SecA Sfri_3796 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 114561627 Common hemC porphobilinogen deaminase Sfri_0440 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 114561792 Common - GCN5-related N-acetyltransferase Sfri_0607 7 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 114563018 Common - response regulator receiver protein Sfri_1844 213 COG4567 COG4567, Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain Signal transduction mechanisms / Transcription 114563060 Common - acyl-CoA dehydrogenase Sfri_1889 149 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 114564944 Common - ISSod10, transposase OrfB Sfri_3794 37 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 114562452 Common - undecaprenyl diphosphate synthase Sfri_1274 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 114562649 Common - Lysine exporter protein (LYSE/YGGA) Sfri_1472 79 COG1279 COG1279, Lysine efflux permease General function prediction only 114564059 Common - peptidase M28 Sfri_2895 48 COG2234 Iap, Predicted aminopeptidases General function prediction only 114564456 Common - periplasmic sensor signal transduction histidine kinase Sfri_3295 207 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114564342 Common - cysteine desulfurases, SufS subfamily Sfri_3181 237 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 114563510 Common - Auxin Efflux Carrier Sfri_2339 90 COG0679 COG0679, Predicted permeases General function prediction only 114563067 Common - hypothetical protein Sfri_1896 33 COG3812 COG3812, Uncharacterized protein conserved in bacteria Function unknown 114562270 Common - alkylphosphonate utilization operon protein PhnA Sfri_1092 105 COG2824 PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism Inorganic ion transport and metabolism 114564467 Common - Cytochrome b/b6, N-terminal domain protein Sfri_3306 149 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 114564408 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Sfri_3247 74 COG0546 Gph, Predicted phosphatases General function prediction only 114562922 Common - Superoxide dismutase Sfri_1747 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 114562004 Common - TonB-dependent receptor, plug Sfri_0824 125 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 114565113 Common - hypothetical protein Sfri_3963 20 COG2841 COG2841, Uncharacterized protein conserved in bacteria Function unknown 114564786 Common - hypothetical protein Sfri_3634 1 None None None 114564400 Common - WD-40 repeat protein Sfri_3239 35 COG2319 COG2319, FOG: WD40 repeat General function prediction only 114561495 Common - RNA methyltransferase, TrmH family, group 2 Sfri_0307 160 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 114563465 Common - transcriptional regulator, MarR family protein Sfri_2294 116 COG1846 MarR, Transcriptional regulators Transcription 114564904 Common - MSHA biogenesis protein MshK Sfri_3752 1 None None None 114564577 Nonpathogen - hypothetical protein Sfri_3416 5 None None None 114561256 Common - protein of unknown function DUF6, transmembrane Sfri_0068 58 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 114563181 Common - cytochrome c oxidase, cbb3-type, subunit I Sfri_2010 150 COG3278 CcoN, Cbb3-type cytochrome oxidase, subunit 1 Posttranslational modification, protein turnover, chaperones 114563656 Common - two component transcriptional regulator, winged helix family protein Sfri_2486 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114563006 Common - AMP-dependent synthetase and ligase Sfri_1832 204 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 114565022 Common - transcriptional regulator, MerR family protein Sfri_3872 113 COG0789 SoxR, Predicted transcriptional regulators Transcription 114564252 Common - Trans-hexaprenyltranstransferase Sfri_3090 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 114564730 Common - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Sfri_3578 146 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 114563779 Common - putative tRNA-(MSA)-hydroxylase Sfri_2613 13 COG4445 MiaE, Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 114564556 Common - hydrolase of the alpha/beta superfamily Sfri_3395 47 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 114562652 Common - biotin synthase Sfri_1475 181 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 114561922 Common - Spore coat assembly protein-like protein Sfri_0739 18 COG5337 CotH, Spore coat assembly protein Cell envelope biogenesis, outer membrane 114564722 Common - Radical SAM domain protein Sfri_3570 53 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 114561396 Common - major facilitator superfamily MFS_1 Sfri_0208 221 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 114564633 Common - sulfatase Sfri_3478 62 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 114562989 Common - efflux transporter, RND family, MFP subunit Sfri_1814 168 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 114563562 Common - FAD-binding 9, siderophore-interacting domain protein Sfri_2392 59 COG2375 ViuB, Siderophore-interacting protein Inorganic ion transport and metabolism 114563711 Common - hypothetical protein Sfri_2544 4 None None None 114564330 Common - multi-sensor hybrid histidine kinase Sfri_3169 224 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 114564095 Common - GTP-binding protein LepA Sfri_2931 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 114562669 Common - maf protein Sfri_1493 190 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 114564309 Nonpathogen - hypothetical protein Sfri_3148 1 None None None 114563976 Common - diguanylate cyclase Sfri_2812 220 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 114562826 Common - hypothetical protein Sfri_1650 2 None None None 114563514 Common kgd alpha-ketoglutarate decarboxylase Sfri_2343 147 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 114565153 Common - Bile acid:sodium symporter Sfri_4003 129 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 114561845 Common - ATP-dependent RNA helicase SrmB Sfri_0660 233 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 114562108 Common - GCN5-related N-acetyltransferase Sfri_0930 22 COG0456 RimI, Acetyltransferases General function prediction only 114564735 Common - sodium/hydrogen exchanger Sfri_3583 133 COG3263 COG3263, NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain Inorganic ion transport and metabolism 114564594 Nonpathogen - hypothetical protein Sfri_3437 4 COG3450 COG3450, Predicted enzyme of the cupin superfamily General function prediction only 114564472 Common - RNA chaperone Hfq Sfri_3311 127 COG1923 Hfq, Uncharacterized host factor I protein General function prediction only 114562324 Common - methyl-accepting chemotaxis sensory transducer Sfri_1146 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114562490 Common - tryptophan halogenase Sfri_1312 16 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 114563094 Common - hypothetical protein Sfri_1923 3 None None None 114561421 Common - hypothetical protein Sfri_0233 3 None None None 114562708 Common - nitroreductase Sfri_1532 82 COG0778 NfnB, Nitroreductase Energy production and conversion 114562156 Common - hypothetical protein Sfri_0978 3 None None None 114561708 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Sfri_0522 218 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 114564564 Common - uridine phosphorylase Sfri_3403 98 COG2820 Udp, Uridine phosphorylase Nucleotide transport and metabolism 114564814 Common - MATE efflux family protein Sfri_3662 175 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 114564021 Common - Integrase, catalytic region Sfri_2857 121 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 114564050 Common - type IV pilus modification protein PilV Sfri_2886 9 COG4967 PilV, Tfp pilus assembly protein PilV Cell motility and secretion / Intracellular trafficking and secretion 114564808 Common - transcriptional regulator, XRE family protein Sfri_3656 4 COG1396 HipB, Predicted transcriptional regulators Transcription 114564300 Common - transcriptional regulator, LysR family protein Sfri_3138 103 COG0583 LysR, Transcriptional regulator Transcription 114561367 Common - heme exporter protein CcmA Sfri_0179 249 COG4133 CcmA, ABC-type transport system involved in cytochrome c biogenesis, ATPase component Posttranslational modification, protein turnover, chaperones 114562352 Common - flagellar protein FlaG protein Sfri_1174 38 COG1334 FlaG, Uncharacterized flagellar protein FlaG Cell motility and secretion 114561292 Common - general secretion pathway protein C Sfri_0104 28 COG3031 PulC, Type II secretory pathway, component PulC Intracellular trafficking and secretion 114564788 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Sfri_3636 134 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 114562735 Common - ISSod10, transposase OrfB Sfri_1559 39 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 114561489 Common - Methyltransferase type 11 Sfri_0301 33 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 114562417 Nonpathogen - hypothetical protein Sfri_1239 9 None None None 114563055 Common - SEC-C motif domain protein Sfri_1884 88 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 114562979 Common - protein of unknown function UPF0005 Sfri_1804 135 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 114565085 Common - 3-deoxy-D-manno-octulosonic-acid kinase Sfri_3935 23 COG0478 COG0478, RIO-like serine/threonine protein kinase fused to N-terminal HTH domain Signal transduction mechanisms 114561442 Common - hypothetical protein Sfri_0254 3 None None None 114562755 Common cls cardiolipin synthetase Sfri_1579 151 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 114564394 Common - hypoxanthine phosphoribosyltransferase Sfri_3233 157 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 114562502 Common - glutathione-dependent formaldehyde-activating, GFA Sfri_1324 68 COG3791 COG3791, Uncharacterized conserved protein Function unknown 114562976 Common - putative uncharacterized protein involved in oxidation of intracellular sulfur Sfri_1801 5 COG2168 DsrH, Uncharacterized conserved protein involved in oxidation of intracellular sulfur Inorganic ion transport and metabolism 114561644 Common - fumarate reductase Sfri_0457 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 114562904 Common - hypothetical protein Sfri_1729 1 None None None 114563676 Common - NADH:flavin oxidoreductase/NADH oxidase Sfri_2507 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 114564680 Common - hypothetical protein Sfri_3528 13 None None None 114563750 Common - ABC transporter related Sfri_2584 249 COG4167 SapF, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 114562482 Common - NADH:flavin oxidoreductase/NADH oxidase Sfri_1304 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 114564957 Common - phospho-N-acetylmuramoyl-pentapeptide-transferase Sfri_3807 225 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 114564081 Common rplS 50S ribosomal protein L19 Sfri_2917 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 114562357 Common - PAS/PAC sensor signal transduction histidine kinase Sfri_1179 217 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 114563432 Common - hypothetical protein Sfri_2261 41 COG2915 COG2915, Uncharacterized protein involved in purine metabolism General function prediction only 114562960 Common - alpha amylase, catalytic region Sfri_1785 159 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 114563770 Nonpathogen - hypothetical protein Sfri_2604 1 None None None 114564151 Common - ribosomal RNA large subunit methyltransferase A, putative Sfri_2987 43 None None None 114561388 Common - (2Fe-2S)-binding domain protein Sfri_0200 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 114563733 Common - ABC transporter related Sfri_2567 249 COG4181 COG4181, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 114565013 Common - efflux transporter, RND family, MFP subunit Sfri_3863 149 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 114563099 Common - CoA-binding domain protein Sfri_1928 146 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 114563280 Common - hydrogenase accessory protein HypB Sfri_2109 121 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 114564379 Common - hypothetical protein Sfri_3218 1 None None None 114562511 Common - protein of unknown function DUF925 Sfri_1333 22 COG3575 COG3575, Uncharacterized protein conserved in bacteria Function unknown 114563796 Common dinG ATP-dependent DNA helicase DinG Sfri_2630 131 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 114562422 Common - ApbE family lipoprotein Sfri_1244 137 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 114561994 Common - hypothetical protein Sfri_0814 1 None None None 114564035 Common - hypothetical protein Sfri_2871 24 COG3171 COG3171, Uncharacterized protein conserved in bacteria Function unknown 114565093 Common - DNA polymerase I Sfri_3943 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 114563927 Common - hypothetical protein Sfri_2762 1 None None None 114563717 Common ddl D-alanyl-alanine synthetase A Sfri_2550 209 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 114561685 Common - secretion protein HlyD family protein Sfri_0499 166 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 114562273 Common - cyclase/dehydrase Sfri_1095 102 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 114564858 Nonpathogen - putative anti-sigma regulatory factor, serine/threonine protein kinase Sfri_3706 7 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 114561906 Common prfA peptide chain release factor 1 Sfri_0723 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 114562545 Common - peptide synthase Sfri_1367 215 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 114564266 Common - Heparinase II/III family protein Sfri_3104 9 None None None 114564278 Common - polysaccharide deacetylase Sfri_3116 7 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 114563127 Common - type I site-specific deoxyribonuclease, HsdR family protein Sfri_1956 136 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 114564990 Common - protein of unknown function DUF1006 Sfri_3840 61 COG3214 COG3214, Uncharacterized protein conserved in bacteria Function unknown 114561674 Common - hypothetical protein Sfri_0487 7 None None None 114561722 Common - Succinylglutamate desuccinylase/aspartoacylase Sfri_0536 25 COG3608 COG3608, Predicted deacylase General function prediction only 114562174 Common - lipoprotein NlpI Sfri_0996 59 COG4785 NlpI, Lipoprotein NlpI, contains TPR repeats General function prediction only 114563324 Common - DEAD/DEAH box helicase domain protein Sfri_2153 236 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 114562366 Common fliL flagellar basal body-associated protein FliL Sfri_1188 15 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 114563992 Common - dTDP-4-dehydrorhamnose reductase Sfri_2828 181 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 114561207 Common - Protoporphyrinogen oxidase Sfri_0019 34 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 114563336 Common - glycogen branching enzyme Sfri_2165 146 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 114563179 Common - hypothetical protein Sfri_2008 1 None None None 114561480 Nonpathogen - hypothetical protein Sfri_0292 1 None None None 114561869 Common - Integrase, catalytic region Sfri_0685 143 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 114563332 Common - Starch synthase Sfri_2161 127 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 114563349 Common - endonuclease III Sfri_2178 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 114562632 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Sfri_1455 225 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 114561818 Common - ferredoxin-dependent glutamate synthase Sfri_0633 202 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 114561976 Common - Bile acid:sodium symporter Sfri_0796 78 COG0385 COG0385, Predicted Na+-dependent transporter General function prediction only 114563064 Common - 6-phosphogluconolactonase Sfri_1893 118 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 114562236 Common - protein-L-isoaspartate O-methyltransferase Sfri_1058 158 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 114561957 Common - transcriptional regulator, LysR family protein Sfri_0776 143 COG0583 LysR, Transcriptional regulator Transcription 114563910 Common - thymidine kinase Sfri_2745 97 COG1435 Tdk, Thymidine kinase Nucleotide transport and metabolism 114564337 Common - lipoprotein, putative Sfri_3176 18 None None None 114561729 Common - hypothetical protein Sfri_0543 206 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 114563372 Common - thiamine biosynthesis protein ThiC Sfri_2201 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 114562530 Common - methyl-accepting chemotaxis sensory transducer Sfri_1352 156 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114561287 Common - hypothetical protein Sfri_0099 15 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 114564701 Nonpathogen - hypothetical protein Sfri_3549 2 None None None 114563686 Common - transcriptional regulator, MarR family protein Sfri_2518 63 COG1846 MarR, Transcriptional regulators Transcription 114565160 Common - TonB-dependent receptor, plug Sfri_4010 124 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 114561581 Common - hypothetical protein Sfri_0393 7 COG2831 FhaC, Hemolysin activation/secretion protein Intracellular trafficking and secretion 114564767 Common - Integrase, catalytic region Sfri_3615 143 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 114564352 Common - phosphoadenosine phosphosulfate reductase Sfri_3191 152 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 114564689 Common - hypothetical protein Sfri_3537 87 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 114563897 Common - 3-oxoacid CoA-transferase, A subunit Sfri_2732 102 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 114562090 Common - transcriptional regulator, LysR family protein Sfri_0912 49 COG0583 LysR, Transcriptional regulator Transcription 114564694 Common - hypothetical protein Sfri_3542 21 None None None 114561586 Common - transposase IS116/IS110/IS902 family protein Sfri_0399 91 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 114563223 Common - hypothetical protein Sfri_2052 3 None None None 114564268 Common - major facilitator superfamily MFS_1 Sfri_3106 210 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 114562578 Common - DNA topoisomerase III Sfri_1401 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 114563220 Common - hypothetical protein Sfri_2049 3 None None None 114563985 Common - hypothetical protein Sfri_2821 28 None None None 114564600 Common - hypothetical protein Sfri_3443 7 None None None 114565043 Common - anaerobic c4-dicarboxylate antiporter, Dcu family protein Sfri_3893 36 COG2704 DcuB, Anaerobic C4-dicarboxylate transporter General function prediction only 114562878 Common - protein of unknown function DUF188 Sfri_1703 98 COG1671 COG1671, Uncharacterized protein conserved in bacteria Function unknown 114563307 Common - hypothetical protein Sfri_2136 4 None None None 114561597 Common - DSBA oxidoreductase Sfri_0410 74 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 114562833 Nonpathogen - hypothetical protein Sfri_1657 1 None None None 114564551 Common fre FMN reductase Sfri_3390 99 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 114563477 Common - protein of unknown function DUF938 Sfri_2306 49 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 114562034 Common - methylation site containing protein Sfri_0856 1 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 114564083 Common rimM 16S rRNA-processing protein Sfri_2919 167 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 114562856 Nonpathogen - hypothetical protein Sfri_1680 1 None None None 114563050 Common - Pyridoxal-5'-phosphate-dependent enzyme, beta subunit Sfri_1878 218 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 114562381 Common - chemotaxis-specific methylesterase Sfri_1203 214 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 114563963 Common - iron-containing alcohol dehydrogenase Sfri_2798 175 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 114564861 Common - putative hydrolase Sfri_3709 71 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 114562763 Common - GCN5-related N-acetyltransferase Sfri_1587 46 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 114563418 Common - potassium efflux system protein Sfri_2247 202 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 114562465 Common - peptidase M28 Sfri_1287 44 COG2234 Iap, Predicted aminopeptidases General function prediction only 114563744 Common - phage shock protein A, PspA Sfri_2578 80 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 114563229 Common - ATPase associated with various cellular activities, AAA_5 Sfri_2058 98 COG0714 COG0714, MoxR-like ATPases General function prediction only 114564198 Common - protein of unknown function DUF1486 Sfri_3035 26 None None None 114563080 Common - hypothetical protein Sfri_1909 23 COG4394 COG4394, Uncharacterized protein conserved in bacteria Function unknown 114563864 Common secF preprotein translocase subunit SecF Sfri_2699 202 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 114562052 Common - ABC transporter related Sfri_0874 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 114563525 Common - YD repeat protein Sfri_2355 66 COG3209 RhsA, Rhs family protein Cell envelope biogenesis, outer membrane 114561241 Common - hypothetical protein Sfri_0053 8 None None None 114562509 Common - fumarylacetoacetate (FAA) hydrolase Sfri_1331 60 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 114561375 Common - hypothetical protein Sfri_0187 4 COG5373 COG5373, Predicted membrane protein Function unknown 114564646 Common - hypothetical protein Sfri_3493 8 None None None 114562013 Common - putative manganese transporter Sfri_0835 24 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 114564601 Common - phage integrase family protein Sfri_3444 168 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 114562901 Common - thiol-disulfide isomerase and thioredoxins Sfri_1726 63 None None None 114561297 Common - general secretion pathway protein H Sfri_0109 23 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 114563788 Common - TonB family protein Sfri_2622 34 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 114562073 Common - periplasmic binding protein Sfri_0895 155 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 114565088 Common - 2-amino-3-ketobutyrate coenzyme A ligase Sfri_3938 198 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 114564679 Common - diguanylate cyclase/phosphodiesterase Sfri_3527 164 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 114564853 Common - toluene tolerance family protein Sfri_3701 85 COG2854 Ttg2D, ABC-type transport system involved in resistance to organic solvents, auxiliary component Secondary metabolites biosynthesis, transport, and catabolism 114565127 Common - TAP domain protein Sfri_3977 37 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114562305 Common - ApbE family lipoprotein Sfri_1127 135 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 114563278 Common - hypothetical protein Sfri_2107 5 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 114563644 Common pflA pyruvate formate lyase-activating enzyme 1 Sfri_2474 102 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 114565000 Common - Lipase chaperone-like protein Sfri_3850 6 COG5380 LimK, Lipase chaperone Posttranslational modification, protein turnover, chaperones 114562521 Common - 3-hydroxyisobutyrate dehydrogenase Sfri_1343 164 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 114562711 Common - hypothetical protein Sfri_1535 113 COG1054 COG1054, Predicted sulfurtransferase General function prediction only 114563190 Common - universal stress protein UspE Sfri_2019 70 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 114562266 Common - transcriptional regulator, TetR family protein Sfri_1088 102 COG1309 AcrR, Transcriptional regulator Transcription 114563363 Common - hypothetical protein Sfri_2192 3 None None None 114561520 Common - D-tyrosyl-tRNA(Tyr) deacylase Sfri_0332 139 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 114563765 Common cysS cysteinyl-tRNA synthetase Sfri_2599 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 114562240 Common recA recombinase A Sfri_1062 222 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 114564041 Common - SapC family protein Sfri_2877 26 None None None 114564201 Common - Deoxyribodipyrimidine photo-lyase Sfri_3038 135 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 114564507 Common - replicative DNA helicase Sfri_3346 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 114561948 Common - diguanylate cyclase/phosphodiesterase Sfri_0767 179 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114562146 Common - hypothetical protein Sfri_0968 1 None None None 114564158 Common - GatB/Yqey domain protein Sfri_2994 151 COG1610 COG1610, Uncharacterized conserved protein Function unknown 114561832 Common - transketolase Sfri_0647 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 114564362 Common - lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase Sfri_3201 104 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 114563297 Common - aromatic amino acid aminotransferase Sfri_2126 75 COG1448 TyrB, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 114562339 Common flgB flagellar basal body rod protein FlgB Sfri_1161 88 COG1815 FlgB, Flagellar basal body protein Cell motility and secretion 114561895 Common - PhoH family protein Sfri_0712 198 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 114562596 Common - hypothetical protein Sfri_1419 3 None None None 114563140 Common - copper-resistance protein, CopA family protein Sfri_1969 121 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 114561616 Common - diguanylate cyclase/phosphodiesterase with GAF sensor Sfri_0429 179 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114563835 Common - hypothetical protein Sfri_2669 73 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 114564907 Common - conserved hypothetical biogenesis protein MshI Sfri_3755 11 None None None 114563300 Common - phosphoserine aminotransferase Sfri_2129 113 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 114564837 Common - outer membrane protein Sfri_3685 8 None None None 114562664 Common - 2OG-Fe(II) oxygenase Sfri_1487 55 COG3491 PcbC, Isopenicillin N synthase and related dioxygenases General function prediction only 114564710 Common - peptidase S16, lon domain protein Sfri_3558 23 COG2802 COG2802, Uncharacterized protein, similar to the N-terminal domain of Lon protease General function prediction only 114564314 Common - 2-polyprenyl-6-methoxyphenol 4-hydroxylase Sfri_3153 114 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 114562065 Common - Beta-lactamase Sfri_0887 25 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 114564461 Common - hypothetical protein Sfri_3300 4 None None None 114564900 Common - type II secretion system protein E Sfri_3748 220 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 114561565 Common - Sporulation domain protein Sfri_0377 7 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 114562375 Common flhF flagellar biosynthesis regulator FlhF Sfri_1197 245 COG1419 FlhF, Flagellar GTP-binding protein Cell motility and secretion 114564499 Common - hypothetical protein Sfri_3338 1 None None None 114562388 Common - hypothetical protein Sfri_1210 37 COG5587 COG5587, Uncharacterized conserved protein Function unknown 114563285 Nonpathogen - hypothetical protein Sfri_2114 1 None None None 114561609 Common - acetolactate synthase 2 catalytic subunit Sfri_0422 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 114563167 Common - periplasmic nitrate reductase NapE Sfri_1996 2 COG4459 NapE, Periplasmic nitrate reductase system, NapE component Energy production and conversion 114564885 Common - hypothetical protein Sfri_3733 54 COG3164 COG3164, Predicted membrane protein Function unknown 114565137 Common - PfkB domain protein Sfri_3987 171 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 114563772 Common - hypothetical protein Sfri_2606 15 None None None 114561527 Common - Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ Sfri_0339 25 COG4706 COG4706, Predicted 3-hydroxylacyl-(acyl carrier protein) dehydratase Lipid metabolism 114561904 Common - outer membrane lipoprotein LolB Sfri_0721 29 COG3017 LolB, Outer membrane lipoprotein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 114564045 Common - methylation site containing protein Sfri_2881 6 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 114562168 Common infB translation initiation factor IF-2 Sfri_0990 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 114561751 Common - protein of unknown function DUF47 Sfri_0565 37 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 114562935 Common - iron-containing alcohol dehydrogenase Sfri_1760 142 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 114564682 Common - hypothetical protein Sfri_3530 1 None None None 114561308 Common - selenide, water dikinase Sfri_0120 126 COG0709 SelD, Selenophosphate synthase Amino acid transport and metabolism 114563530 Common - Rhs element Vgr protein Sfri_2360 67 COG3501 VgrG, Uncharacterized protein conserved in bacteria Function unknown 114562779 Common - hypothetical protein Sfri_1603 21 COG3602 COG3602, Uncharacterized protein conserved in bacteria Function unknown 114561461 Nonpathogen - hypothetical protein Sfri_0273 1 None None None 114564191 Common - hypothetical protein Sfri_3028 36 None None None 114561412 Common - ubiquinol oxidase, subunit II Sfri_0224 105 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 114564175 Common - peptidase C26 Sfri_3012 120 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 114564288 Common - cytoplasmic chaperone TorD family protein Sfri_3126 25 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 114561853 Common - protein of unknown function DUF152 Sfri_0668 182 COG1496 COG1496, Uncharacterized conserved protein Function unknown 114563016 Common - amino acid carrier protein Sfri_1842 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 114564872 Common - hypothetical protein Sfri_3720 4 None None None 114564233 Common purT phosphoribosylglycinamide formyltransferase 2 Sfri_3070 212 COG0027 PurT, Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) Nucleotide transport and metabolism 114563692 Common - hypothetical protein Sfri_2524 7 None None None 114563746 Common - extracellular solute-binding protein, family 5 Sfri_2580 205 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 114563709 Common - Alkaline phosphatase Sfri_2542 86 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 114564644 Common - Mercuric transport protein MerT Sfri_3491 18 None None None 114562968 Common - alanine dehydrogenase Sfri_1793 167 COG0686 Ald, Alanine dehydrogenase Amino acid transport and metabolism 114561370 Common - cytochrome c-type biogenesis protein CcmF Sfri_0182 134 COG1138 CcmF, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 114561931 Common - transcriptional regulator, LysR family protein Sfri_0749 173 COG0583 LysR, Transcriptional regulator Transcription 114561466 Common - RNA polymerase factor sigma-32 Sfri_0278 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 114562944 Common - phosphocarrier, HPr family protein Sfri_1769 100 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 114562115 Common - aldehyde dehydrogenase Sfri_0937 218 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 114561473 Common - inner membrane protein YjeH Sfri_0285 169 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 114563437 Common - metallophosphoesterase Sfri_2266 75 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 114561871 Common - aromatic amino acid permease Sfri_0688 33 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 114563614 Common - Patatin Sfri_2444 123 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 114564437 Common - transcriptional regulators, TraR/DksA family protein Sfri_3276 132 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 114562206 Common - protein of unknown function DUF88 Sfri_1028 31 COG1432 COG1432, Uncharacterized conserved protein Function unknown 114564133 Common - protein of unknown function UPF0126 Sfri_2969 133 COG2860 COG2860, Predicted membrane protein Function unknown 114562160 Common rrmJ 23S rRNA methyltransferase J Sfri_0982 139 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 114562813 Common - cytidine deaminase Sfri_1637 30 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 114563028 Common - transcriptional regulator, LysR family protein Sfri_1855 158 COG0583 LysR, Transcriptional regulator Transcription 114564890 Common - cell shape determining protein, MreB/Mrl family protein Sfri_3738 233 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 114564684 Common - histone family protein DNA-binding protein Sfri_3532 211 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 114564496 Common - protein of unknown function DUF461 Sfri_3335 82 COG2847 COG2847, Uncharacterized protein conserved in bacteria Function unknown 114564138 Common - hypothetical protein Sfri_2974 15 None None None 114562503 Common - protein of unknown function DUF583 Sfri_1325 35 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 114564297 Common - CBS domain containing membrane protein Sfri_3135 72 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 114562140 Common - aminoacyl-histidine dipeptidase Sfri_0962 58 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 114561965 Common - ybaK/ebsC protein Sfri_0785 109 COG2606 EbsC, Uncharacterized conserved protein Function unknown 114562924 Common - uracil-xanthine permease Sfri_1749 126 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 114563103 Common - thioredoxin reductase Sfri_1932 248 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 114564477 Common - hypothetical protein Sfri_3316 4 None None None 114564107 Common - protein of unknown function DUF81 Sfri_2943 79 COG0730 COG0730, Predicted permeases General function prediction only 114563536 Common - virulence protein, SciE type Sfri_2366 23 COG4455 ImpE, Protein of avirulence locus involved in temperature-dependent protein secretion General function prediction only 114563257 Nonpathogen - hypothetical protein Sfri_2086 1 None None None 114563549 Common - OmpA/MotB domain protein Sfri_2379 56 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 114564161 Common - hypothetical protein Sfri_2998 15 None None None 114563489 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sfri_2318 134 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 114561556 Common - nucleotidase Sfri_0368 99 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 114562473 Common - hypothetical protein Sfri_1295 15 COG5343 COG5343, Uncharacterized protein conserved in bacteria Function unknown 114564088 Common - protein of unknown function DUF962 Sfri_2924 27 COG4539 COG4539, Predicted membrane protein Function unknown 114561320 Common - biotin--protein ligase Sfri_0132 227 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 114564774 Common - band 7 protein Sfri_3622 48 COG2268 COG2268, Uncharacterized protein conserved in bacteria Function unknown 114561800 Common - hypothetical protein Sfri_0615 22 None None None 114561692 Common - hypothetical protein Sfri_0506 2 None None None 114562575 Common - Colicin V production protein Sfri_1398 56 COG1286 CvpA, Uncharacterized membrane protein, required for colicin V production General function prediction only 114561727 Common - Alkaline phosphatase Sfri_0541 83 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 114563020 Common - hypothetical protein Sfri_1847 10 None None None 114561510 Common - hypothetical protein Sfri_0322 15 None None None 114564919 Nonpathogen - hypothetical protein Sfri_3767 1 None None None 114563873 Common - response regulator receiver modulated CheW protein Sfri_2708 185 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 114565203 Common - parB-like partition proteins Sfri_4053 179 COG1475 Spo0J, Predicted transcriptional regulators Transcription 114562876 Nonpathogen - hypothetical protein Sfri_1701 1 None None None 114563086 Common - phosphoglucomutase Sfri_1915 186 COG0033 Pgm, Phosphoglucomutase Carbohydrate transport and metabolism 114564649 Common - hypothetical protein Sfri_3496 14 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 114561500 Common - hypothetical protein Sfri_0312 10 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 114561195 Common glyQ glycyl-tRNA synthetase subunit alpha Sfri_0007 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 114561879 Common - rare lipoprotein A Sfri_0696 137 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 114561973 Common - hypothetical protein Sfri_0793 54 COG2968 COG2968, Uncharacterized conserved protein Function unknown 114564582 Common - hypothetical protein Sfri_3421 2 None None None 114565213 Common - 60 kDa inner membrane insertion protein Sfri_4063 213 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 114561650 Common - hypothetical protein Sfri_0463 7 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 114564530 Common - protein of unknown function DUF140 Sfri_3369 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 114564658 Common - major facilitator superfamily MFS_1 Sfri_3505 29 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 114564921 Nonpathogen - hypothetical protein Sfri_3769 1 None None None 114564712 Common - conserved hypothetical protein 22 Sfri_3560 33 COG2731 EbgC, Beta-galactosidase, beta subunit Carbohydrate transport and metabolism 114562600 Common - hypothetical protein Sfri_1423 15 None None None 114564116 Common gltD glutamate synthase subunit beta Sfri_2952 203 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 114564746 Common - hypothetical protein Sfri_3594 4 None None None 114563841 Common fadJ multifunctional fatty acid oxidation complex subunit alpha Sfri_2676 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 114562139 Common - DNA polymerase IV Sfri_0961 183 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 114561261 Common - iron-containing alcohol dehydrogenase Sfri_0073 168 COG1979 COG1979, Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family Energy production and conversion 114562537 Common - phosphate ABC transporter, ATPase subunit Sfri_1359 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 114561579 Common - TonB-dependent siderophore receptor Sfri_0391 118 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 114562190 Common - nucleoside recognition domain protein Sfri_1012 21 COG3314 COG3314, Uncharacterized protein conserved in bacteria Function unknown 114564960 Common - Peptidoglycan glycosyltransferase Sfri_3810 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 114563291 Common - hypothetical protein Sfri_2120 62 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 114561706 Common - hypothetical protein Sfri_0520 59 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 114564127 Common - putative sterol desaturase Sfri_2963 80 COG3000 ERG3, Sterol desaturase Lipid metabolism 114561943 Common - gamma-glutamyl phosphate reductase Sfri_0762 189 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 114565143 Common - transcriptional regulator, TetR family protein Sfri_3993 90 COG1309 AcrR, Transcriptional regulator Transcription 114563249 Common - peptidase U32 Sfri_2078 138 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 114562137 Nonpathogen - hypothetical protein Sfri_0959 2 None None None 114561742 Common - ABC transporter related Sfri_0556 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 114561537 Common - hypothetical protein Sfri_0349 66 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 114563671 Common - protein of unknown function DUF6, transmembrane Sfri_2502 68 COG2962 RarD, Predicted permeases General function prediction only 114562292 Common - type IV pilus biogenesis/stability protein PilW Sfri_1114 85 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 114561348 Common rplE 50S ribosomal protein L5 Sfri_0160 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 114562043 Common - transposase IS3/IS911 family protein Sfri_0865 50 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 114561478 Common - TrkA-C domain protein Sfri_0290 153 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 114561665 Common - hypothetical protein Sfri_0478 11 None None None 114561618 Common - hypothetical protein Sfri_0431 31 COG3672 COG3672, Predicted periplasmic protein Function unknown 114563164 Common torD chaperone protein TorD Sfri_1993 14 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 114563915 Common - lipoprotein, putative Sfri_2750 10 None None None 114564866 Common - DEAD/DEAH box helicase domain protein Sfri_3714 234 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 114561318 Common - ISSod10, transposase OrfA Sfri_0130 26 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 114561788 Common - 23S rRNA pseudouridine synthase F Sfri_0603 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 114562113 Common - protein of unknown function DUF1289 Sfri_0935 23 COG3313 COG3313, Predicted Fe-S protein General function prediction only 114562994 Common proX glycine betaine transporter periplasmic subunit Sfri_1819 44 COG2113 ProX, ABC-type proline/glycine betaine transport systems, periplasmic components Amino acid transport and metabolism 114564412 Common - secretion protein HlyD family protein Sfri_3251 117 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 114561761 Common - protein of unknown function UPF0016 Sfri_0575 76 COG2119 COG2119, Predicted membrane protein Function unknown 114564897 Common - methylation site containing protein Sfri_3745 7 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 114563379 Common - Lytic transglycosylase, catalytic Sfri_2208 127 COG4623 COG4623, Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein Cell envelope biogenesis, outer membrane 114562299 Common - hypothetical protein Sfri_1121 14 None None None 114564247 Common - hypothetical protein Sfri_3085 43 COG3610 COG3610, Uncharacterized conserved protein Function unknown 114562354 Common - hypothetical protein Sfri_1176 1 None None None 114563208 Common - hypothetical protein Sfri_2037 49 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 114562359 Common - flagellar hook-basal body complex subunit FliE Sfri_1181 81 COG1677 FliE, Flagellar hook-basal body protein Cell motility and secretion / Intracellular trafficking and secretion 114564324 Common folX D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase Sfri_3163 61 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 114562560 Common - hypothetical protein Sfri_1383 14 COG5338 COG5338, Uncharacterized protein conserved in bacteria Function unknown 114562185 Common - phosphoserine phosphatase SerB Sfri_1007 145 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 114565190 Common - glucosamine--fructose-6-phosphate aminotransferase, isomerizing Sfri_4040 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 114562957 Nonpathogen - hypothetical protein Sfri_1782 2 None None None 114564791 Nonpathogen - hypothetical protein Sfri_3639 1 None None None 114564733 Common - putative lipoprotein Sfri_3581 23 None None None 114562694 Common - hypothetical protein Sfri_1518 8 None None None 114563944 Common - isocitrate dehydrogenase Sfri_2779 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 114562597 Common - exonuclease III Sfri_1420 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 114562001 Common - peptidase U32 Sfri_0821 140 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 114562950 Common - Glucan 1,4-alpha-glucosidase Sfri_1775 28 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 114563455 Common - putative monovalent cation/H+ antiporter subunit B Sfri_2284 98 COG1563 COG1563, Predicted subunit of the Multisubunit Na+/H+ antiporter Inorganic ion transport and metabolism 114561719 Common - DNA-binding response regulator in two-component regulatory system with ArcB or CpxA Sfri_0533 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114564458 Common - aldehyde dehydrogenase Sfri_3297 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 114562400 Common - transcriptional regulator, putative Sfri_1222 27 None None None 114562313 Common - OmpA/MotB domain protein Sfri_1135 164 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 114563382 Common - hypothetical protein Sfri_2211 1 None None None 114563702 Common - exodeoxyribonuclease V, beta subunit Sfri_2534 141 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 114564299 Common - malate synthase G Sfri_3137 67 COG2225 AceB, Malate synthase Energy production and conversion 114564986 Common - ribonuclease PH Sfri_3836 190 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 114563878 Common - ABC transporter related Sfri_2713 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 114565006 Common - hypothetical protein Sfri_3856 58 None None None 114562677 Common - beta-ketoacyl synthase Sfri_1501 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 114562154 Common carB carbamoyl phosphate synthase large subunit Sfri_0976 236 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 114563906 Common - NADH dehydrogenase (quinone) Sfri_2741 208 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 114563446 Common - transcriptional regulator, LysR family protein Sfri_2275 183 COG0583 LysR, Transcriptional regulator Transcription 114562963 Common - alpha amylase, catalytic region Sfri_1788 161 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 114563394 Common - BNR repeat protein Sfri_2223 28 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 114563591 Common hscB co-chaperone HscB Sfri_2421 56 COG1076 DjlA, DnaJ-domain-containing proteins 1 Posttranslational modification, protein turnover, chaperones 114562640 Common - OmpA/MotB domain protein Sfri_1463 147 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 114562390 Common - alpha-L-glutamate ligases, RimK family protein Sfri_1212 155 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 114561651 Common - Integrase, catalytic region Sfri_0464 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 114565071 Common - molybdopterin-guanine dinucleotide biosynthesis protein B Sfri_3921 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 114564842 Common - flavocytochrome c Sfri_3690 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 114562862 Common - hypothetical protein Sfri_1686 10 None None None 114561635 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Sfri_0448 60 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 114563697 Common - Lytic transglycosylase, catalytic Sfri_2529 169 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 114562860 Common - phage tape measure protein Sfri_1684 92 COG3941 COG3941, Mu-like prophage protein General function prediction only 114563892 Common - Isovaleryl-CoA dehydrogenase Sfri_2727 171 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 114561629 Common - Frataxin family protein Sfri_0442 44 COG1965 CyaY, Protein implicated in iron transport, frataxin homolog Inorganic ion transport and metabolism 114561842 Common - Radical SAM domain protein Sfri_0657 14 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 114563957 Common - NAD(+) kinase Sfri_2792 238 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 114564661 Common - ATP-dependent helicase HepA Sfri_3508 135 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 114562294 Common ispG 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase Sfri_1116 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 114564941 Common - mutator MutT protein Sfri_3789 169 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 114564218 Common - H(+)-transporting ATP synthase, subunit B Sfri_3055 66 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 114563658 Common - 2OG-Fe(II) oxygenase Sfri_2488 9 None None None 114563757 Common - pentapeptide repeat protein Sfri_2591 31 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 114563950 Common - thiamine biosynthesis protein ThiI Sfri_2785 94 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 114564090 Common - pyridoxal phosphate biosynthetic protein PdxJ Sfri_2926 139 COG0854 PdxJ, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 114562454 Common - 1-deoxy-D-xylulose 5-phosphate reductoisomerase Sfri_1276 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 114561449 Common - glycerol-3-phosphate acyltransferase Sfri_0261 48 COG2937 PlsB, Glycerol-3-phosphate O-acyltransferase Lipid metabolism 114564057 Common rpsT 30S ribosomal protein S20 Sfri_2893 208 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 114562255 Common - von Willebrand factor, type A Sfri_1077 41 COG2304 COG2304, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 114564910 Common rpmE 50S ribosomal protein L31 Sfri_3758 201 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 114563007 Common - inner-membrane translocator Sfri_1833 152 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 114562919 Common - hypothetical protein Sfri_1744 71 COG2719 SpoVR, Uncharacterized conserved protein Function unknown 114564617 Common - transcriptional regulator, MerR family protein Sfri_3461 138 COG0789 SoxR, Predicted transcriptional regulators Transcription 114563192 Common - hypothetical protein Sfri_2021 6 None None None 114561794 Common - Twin-arginine translocation pathway signal Sfri_0609 67 COG3211 PhoX, Predicted phosphatase General function prediction only 114562647 Common - periplasmic sensor hybrid histidine kinase Sfri_1470 224 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 114563654 Common - ABC transporter related Sfri_2484 249 COG3638 COG3638, ABC-type phosphate/phosphonate transport system, ATPase component Inorganic ion transport and metabolism 114565169 Common - preprotein translocase subunit SecB Sfri_4019 108 COG1952 SecB, Preprotein translocase subunit SecB Intracellular trafficking and secretion 114564969 Common - 3-isopropylmalate dehydrogenase Sfri_3819 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 114561720 Common - hypothetical protein Sfri_0534 4 None None None 114562128 Common - Na(+)-translocating NADH-quinone reductase subunit B Sfri_0950 76 COG1805 NqrB, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB Energy production and conversion 114563202 Common - MATE efflux family protein Sfri_2031 171 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 114563559 Common - DNA internalization-related competence protein ComEC/Rec2 Sfri_2389 148 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 114564430 Common - Ion transport 2 domain protein Sfri_3269 82 None None None 114561493 Common - hypothetical protein Sfri_0305 1 None None None 114563587 Common - Nucleoside-diphosphate kinase Sfri_2417 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 114561254 Common - hypothetical protein Sfri_0066 14 COG5395 COG5395, Predicted membrane protein Function unknown 114564189 Common - hypothetical protein Sfri_3026 1 None None None 114561350 Common rpsH 30S ribosomal protein S8 Sfri_0162 219 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 114563990 Common - glycosyl transferase, group 1 Sfri_2826 29 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 114562607 Common - PHP C-terminal domain protein Sfri_1430 132 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 114564370 Common - Na(+)-translocating NADH-quinone reductase subunit C Sfri_3209 41 COG2869 NqrC, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC Energy production and conversion 114564902 Common - MSHA biogenesis protein MshM Sfri_3750 73 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 114564575 Common - Integrase, catalytic region Sfri_3414 75 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 114563492 Common - hypothetical protein Sfri_2321 15 COG2515 Acd, 1-aminocyclopropane-1-carboxylate deaminase Amino acid transport and metabolism 114561234 Nonpathogen - hypothetical protein Sfri_0046 1 None None None 114565092 Common - isoprenoid biosynthesis protein with amidotransferase-like domain Sfri_3942 38 COG3155 ElbB, Uncharacterized protein involved in an early stage of isoprenoid biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 114563983 Common - transcriptional regulator, MerR family protein Sfri_2819 141 COG0789 SoxR, Predicted transcriptional regulators Transcription 114562618 Common - Twin-arginine translocation pathway signal Sfri_1441 63 COG3108 COG3108, Uncharacterized protein conserved in bacteria Function unknown 114563317 Common ansA cytoplasmic asparaginase I Sfri_2146 135 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 114561824 Common - Dyp-type peroxidase family protein Sfri_0639 55 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 114563213 Common - alpha/beta hydrolase fold Sfri_2042 119 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114562441 Common - flavodoxin Sfri_1263 75 COG0369 CysJ, Sulfite reductase, alpha subunit (flavoprotein) Inorganic ion transport and metabolism 114564635 Common - TetR family transcriptional regulator-like protein Sfri_3480 4 None None None 114564343 Common - Fe-S metabolism associated SufE Sfri_3182 93 COG2166 COG2166, SufE protein probably involved in Fe-S center assembly General function prediction only 114563072 Common - putative nucleoside transport protein Sfri_1901 9 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 114561867 Common - L-asparaginases, type II Sfri_0683 139 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 114564933 Common - nicotinate-nucleotide pyrophosphorylase Sfri_3781 204 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 114563832 Common - major facilitator superfamily MFS_1 Sfri_2666 100 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 114561924 Common - hypothetical protein Sfri_0741 6 None None None 114565177 Common - hypothetical protein Sfri_4027 25 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 114562427 Common - SecY interacting protein Syd Sfri_1249 19 None None None 114562844 Nonpathogen - hypothetical protein Sfri_1668 1 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 114563155 Common - Radical SAM domain protein Sfri_1984 66 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 114562543 Common - 3-oxoacyl-(acyl carrier protein) synthase III Sfri_1365 182 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 114565078 Common - ADP-heptose--lipooligosaccharide heptosyltransferase III Sfri_3928 27 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 114564424 Common - protein of unknown function DUF350 Sfri_3263 5 None None None 114564013 Common - Holliday junction resolvase-like protein Sfri_2849 181 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 114562213 Common - riboflavin biosynthesis protein RibD Sfri_1035 224 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 114564612 Common - efflux transporter, RND family, MFP subunit Sfri_3456 113 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 114562497 Common - Glucan endo-1,3-beta-D-glucosidase Sfri_1319 50 COG2273 SKN1, Beta-glucanase/Beta-glucan synthetase Carbohydrate transport and metabolism 114564540 Common - PTS IIA-like nitrogen-regulatory protein PtsN Sfri_3379 135 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 114561645 Common sdhB succinate dehydrogenase iron-sulfur subunit Sfri_0458 206 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 114564948 Common - hypothetical protein Sfri_3798 10 COG4701 COG4701, Uncharacterized protein conserved in bacteria Function unknown 114563550 Common - hypothetical protein Sfri_2380 2 None None None 114562346 Common flgI flagellar basal body P-ring protein Sfri_1168 105 COG1706 FlgI, Flagellar basal-body P-ring protein Cell motility and secretion 114565058 Common - hypothetical protein Sfri_3908 21 None None None 114561739 Common - periplasmic nitrate reductase, large subunit Sfri_0553 183 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 114562846 Nonpathogen - hypothetical protein Sfri_1670 3 None None None 114561326 Common rplA 50S ribosomal protein L1 Sfri_0138 244 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 114564856 Common - ABC transporter related Sfri_3704 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 114564939 Common - hypothetical protein Sfri_3787 43 COG4582 COG4582, Uncharacterized protein conserved in bacteria Function unknown 114563002 Common - hypothetical protein Sfri_1827 9 None None None 114562910 Common - cell division topological specificity factor MinE Sfri_1735 82 COG0851 MinE, Septum formation topological specificity factor Cell division and chromosome partitioning 114562774 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sfri_1598 32 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 114564998 Common mdoG glucan biosynthesis protein G Sfri_3848 50 COG3131 MdoG, Periplasmic glucans biosynthesis protein Inorganic ion transport and metabolism 114563250 Common - TonB-dependent receptor Sfri_2079 39 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 114563119 Common - transcriptional regulator, TetR family protein Sfri_1948 44 COG1309 AcrR, Transcriptional regulator Transcription 114563516 Common sdhA succinate dehydrogenase flavoprotein subunit Sfri_2345 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 114564237 Common - aminoglycoside phosphotransferase Sfri_3075 91 COG3178 COG3178, Predicted phosphotransferase related to Ser/Thr protein kinases General function prediction only 114564382 Common - hypothetical protein Sfri_3221 3 None None None 114563389 Common - short chain dehydrogenase Sfri_2218 231 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 114562399 Common - beta-ketoacyl synthase Sfri_1221 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 114562223 Common - hypothetical protein Sfri_1045 1 None None None 114563424 Common - translation initiation factor IF-1 Sfri_2253 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 114564926 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Sfri_3774 187 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114561517 Common - hypothetical protein Sfri_0329 14 None None None 114561289 Common - phosphoenolpyruvate carboxykinase Sfri_0101 97 COG1866 PckA, Phosphoenolpyruvate carboxykinase (ATP) Energy production and conversion 114564757 Common - amidohydrolase Sfri_3605 170 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 114562783 Nonpathogen - hypothetical protein Sfri_1607 1 None None None 114563802 Common - decaheme cytochrome c Sfri_2636 9 None None None 114563356 Common - diguanylate cyclase Sfri_2185 190 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114563887 Common - acyl-CoA thioesterase II Sfri_2722 77 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 114561415 Common - Alcohol dehydrogenase, zinc-binding domain protein Sfri_0227 193 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 114564038 Common - hypothetical protein Sfri_2874 72 COG2924 COG2924, Uncharacterized protein conserved in bacteria Function unknown 114564004 Common - SMP-30/Gluconolaconase/LRE domain protein Sfri_2840 60 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 114562199 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Sfri_1021 112 COG2878 COG2878, Predicted NADH:ubiquinone oxidoreductase, subunit RnfB Energy production and conversion 114565029 Common - sodium/sulphate symporter Sfri_3879 112 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 114564829 Common - acriflavin resistance protein Sfri_3677 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 114561407 Nonpathogen - hypothetical protein Sfri_0219 1 None None None 114561547 Common - TPR repeat-containing protein Sfri_0359 5 None None None 114563828 Common - Rhodanese domain protein Sfri_2662 96 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 114563279 Common - (NiFe) hydrogenase maturation protein HypF Sfri_2108 121 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 114561938 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sfri_0756 17 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 114563151 Common - protein of unknown function DUF81 Sfri_1980 102 COG0730 COG0730, Predicted permeases General function prediction only 114561835 Common - fructose-1,6-bisphosphate aldolase Sfri_0650 176 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 114562023 Common - hypothetical protein Sfri_0845 1 None None None 114562622 Common - peptidase T2, asparaginase 2 Sfri_1445 84 COG1446 COG1446, Asparaginase Amino acid transport and metabolism 114563821 Common - conserved hypothetical ATP-dependent protease Sfri_2655 99 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 114561434 Common - peptidase S9, prolyl oligopeptidase active site domain protein Sfri_0246 127 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 114562766 Common - Ion transport protein Sfri_1590 92 COG1226 Kch, Kef-type K+ transport systems, predicted NAD-binding component Inorganic ion transport and metabolism 114563146 Common - hypothetical protein Sfri_1975 4 COG1433 COG1433, Uncharacterized conserved protein Function unknown 114564966 Common - membrane protein involved in aromatic hydrocarbon degradation Sfri_3816 87 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 114564834 Common - cytoplasmic chaperone TorD family protein Sfri_3682 23 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 114561894 Common - hypothetical protein Sfri_0711 201 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 114563359 Common - protein of unknown function DUF785 Sfri_2188 28 COG4067 COG4067, Uncharacterized protein conserved in archaea Posttranslational modification, protein turnover, chaperones 114564143 Common - aspartate carbamoyltransferase Sfri_2979 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 114563646 Common - acetate kinase Sfri_2476 162 COG0282 ackA, Acetate kinase Energy production and conversion 114565130 Common - hypothetical protein Sfri_3980 1 None None None 114564043 Common - nitrogen regulatory protein P-II Sfri_2879 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 114565083 Nonpathogen - glycosyl transferase, family 8 Sfri_3933 1 COG1442 RfaJ, Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases Cell envelope biogenesis, outer membrane 114561732 Common - hypothetical protein Sfri_0546 7 COG2039 Pcp, Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase) Posttranslational modification, protein turnover, chaperones 114563266 Common - hypothetical protein Sfri_2095 106 COG0393 COG0393, Uncharacterized conserved protein Function unknown 114563166 Common - trimethylamine-N-oxide reductase c-type cytochrome TorC Sfri_1995 48 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 114563778 Common - Recombinase Sfri_2612 30 None None None 114565142 Common - NLP/P60 protein Sfri_3992 145 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 114564892 Common - MSHA biogenesis protein MshP Sfri_3740 10 None None None 114563350 Common - lactoylglutathione lyase Sfri_2179 127 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 114562804 Common - acetolactate synthase 3 catalytic subunit Sfri_1628 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 114561864 Common - fumarate reductase cytochrome B subunit Sfri_0680 9 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 114562387 Common - Fmu (Sun) domain protein Sfri_1209 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 114562380 Common - CheA signal transduction histidine kinases Sfri_1202 152 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 114563972 Common - hypothetical protein Sfri_2808 1 None None None 114561355 Common rplO 50S ribosomal protein L15 Sfri_0167 178 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 114562598 Common - YciI-like protein Sfri_1421 66 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 114562032 Common - major facilitator superfamily MFS_1 Sfri_0854 65 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 114561562 Common - type IV pilus secretin PilQ Sfri_0374 139 COG4796 HofQ, Type II secretory pathway, component HofQ Intracellular trafficking and secretion 114562268 Common - serine/threonine protein kinase Sfri_1090 42 COG4886 COG4886, Leucine-rich repeat (LRR) protein Function unknown 114564713 Common - putative manganese-dependent inorganic pyrophosphatase Sfri_3561 54 COG1227 PPX1, Inorganic pyrophosphatase/exopolyphosphatase Energy production and conversion 114563546 Common - hypothetical protein Sfri_2376 32 COG3521 COG3521, Uncharacterized protein conserved in bacteria Function unknown 114562072 Common - hypothetical protein Sfri_0894 24 COG3673 COG3673, Uncharacterized conserved protein Function unknown 114562556 Common - O-antigen polymerase Sfri_1378 13 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 114563412 Common - aminodeoxychorismate lyase Sfri_2241 185 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 114562162 Common - dihydropteroate synthase Sfri_0984 218 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 114563139 Common - protein of unknown function DUF411 Sfri_1968 64 COG3019 COG3019, Predicted metal-binding protein General function prediction only 114562447 Common - methionine aminopeptidase Sfri_1269 247 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 114564888 Common - Rod shape-determining protein MreD Sfri_3736 62 COG2891 MreD, Cell shape-determining protein Cell envelope biogenesis, outer membrane 114564287 Common - hypothetical protein Sfri_3125 1 None None None 114565057 Common - Paraquat-inducible protein A Sfri_3907 14 COG2995 PqiA, Uncharacterized paraquat-inducible protein A Function unknown 114563400 Common - putative solute/DNA competence effector Sfri_2229 34 COG3109 ProQ, Activator of osmoprotectant transporter ProP Signal transduction mechanisms 114564673 Common - hypothetical protein Sfri_3520 1 None None None 114564204 Common - hypothetical protein Sfri_3041 20 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 114565121 Nonpathogen - hypothetical protein Sfri_3971 1 None None None 114561299 Common - general secretion pathway protein J Sfri_0111 30 COG4795 PulJ, Type II secretory pathway, component PulJ Intracellular trafficking and secretion 114562279 Common - malate synthase Sfri_1101 86 COG2225 AceB, Malate synthase Energy production and conversion 114562000 Common - hypoxanthine-guanine phosphoribosyltransferase Sfri_0820 38 COG2236 COG2236, Predicted phosphoribosyltransferases General function prediction only 114562063 Nonpathogen - hypothetical protein Sfri_0885 1 None None None 114562662 Common - protein tyrosine phosphatase Sfri_1485 136 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 114562781 Common - UMP phosphatase Sfri_1605 98 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 114564744 Common - hypothetical protein Sfri_3592 112 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 114561372 Common - cytochrome C biogenesis protein Sfri_0184 91 COG3088 CcmH, Uncharacterized protein involved in biosynthesis of c-type cytochromes Posttranslational modification, protein turnover, chaperones 114563309 Common - hypothetical protein Sfri_2138 22 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 114561902 Common - ribose-phosphate pyrophosphokinase Sfri_0719 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 114561330 Common - DNA-directed RNA polymerase subunit beta' Sfri_0142 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 114561211 Common - methionyl-tRNA formyltransferase Sfri_0023 217 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 114564315 Common - yecA family protein Sfri_3154 42 COG3079 COG3079, Uncharacterized protein conserved in bacteria Function unknown 114565139 Common - major facilitator superfamily MFS_1 Sfri_3989 156 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 114562629 Common - phosphoribosylaminoimidazole synthetase Sfri_1452 232 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 114561591 Common - hypothetical protein Sfri_0404 22 None None None 114562589 Common - protein of unknown function DUF182 Sfri_1412 70 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 114564157 Common rpsU 30S ribosomal protein S21 Sfri_2993 99 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 114563609 Common - hypothetical protein Sfri_2439 13 None None None 114561209 Common trkA potassium transporter peripheral membrane component Sfri_0021 148 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 114562898 Common - Twin-arginine translocation pathway signal Sfri_1723 6 None None None 114563062 Common - DNA-binding transcriptional regulator HexR Sfri_1891 90 COG1737 RpiR, Transcriptional regulators Transcription 114564953 Common - UDP-N-acetylmuramate--alanine ligase Sfri_3803 209 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 114562092 Common - major facilitator superfamily MFS_1 Sfri_0914 110 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 114561301 Common - general secretion pathway protein L Sfri_0113 27 COG3297 PulL, Type II secretory pathway, component PulL Intracellular trafficking and secretion 114564225 Common - two component transcriptional regulator, winged helix family protein Sfri_3062 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114561453 Nonpathogen - hypothetical protein Sfri_0265 1 None None None 114563243 Common - Phosphoglycerate mutase Sfri_2072 23 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 114563679 Common - flavocytochrome c Sfri_2511 132 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 114564609 Common - DNA-directed DNA polymerase Sfri_3453 169 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 114564032 Common - transcriptional regulator, LysR family protein Sfri_2868 168 COG0583 LysR, Transcriptional regulator Transcription 114562729 Common - ISSod10, transposase OrfA Sfri_1553 10 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 114563045 Common - channel protein, hemolysin III family protein Sfri_1873 118 COG1272 COG1272, Predicted membrane protein, hemolysin III homolog General function prediction only 114562504 Common - ferredoxin-type protein NapF Sfri_1326 69 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 114564214 Common - F0F1-ATPase subunit, putative Sfri_3051 18 None None None 114564280 Common - Lysine exporter protein (LYSE/YGGA) Sfri_3118 120 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 114563863 Nonpathogen - hypothetical protein Sfri_2698 5 None None None 114565151 Common - major facilitator superfamily MFS_1 Sfri_4001 40 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 114561428 Common - sulfatase Sfri_0240 77 COG1368 MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily Cell envelope biogenesis, outer membrane 114562131 Common - Na(+)-translocating NADH-quinone reductase subunit E Sfri_0953 76 COG2209 NqrE, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE Energy production and conversion 114562341 Common flgD flagellar basal body rod modification protein Sfri_1163 105 COG1843 FlgD, Flagellar hook capping protein Cell motility and secretion 114562018 Common - hypothetical protein Sfri_0840 7 None None None 114564447 Common - glucose-methanol-choline oxidoreductase Sfri_3286 57 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 114563275 Common - nickel-dependent hydrogenase, large subunit Sfri_2104 106 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 114561501 Common - spheroplast protein y precursor, putative Sfri_0313 16 COG3678 CpxP, P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism 114562424 Common - beta-lactamase domain protein Sfri_1246 44 COG2015 COG2015, Alkyl sulfatase and related hydrolases Secondary metabolites biosynthesis, transport, and catabolism 114563899 Common - hypothetical protein Sfri_2734 29 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 114564367 Common - Na(+)-translocating NADH-quinone reductase subunit F Sfri_3206 160 COG2871 NqrF, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF Energy production and conversion 114563380 Common - AsmA family protein Sfri_2209 66 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 114561587 Nonpathogen - hypothetical protein Sfri_0400 1 None None None 114563486 Common - hypothetical protein Sfri_2315 5 None None None 114562526 Nonpathogen - hypothetical protein Sfri_1348 1 None None None 114561602 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Sfri_0415 193 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114562009 Common - diguanylate cyclase Sfri_0831 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114564688 Common - hypothetical protein Sfri_3536 16 COG3930 COG3930, Uncharacterized protein conserved in bacteria Function unknown 114564663 Common - enoyl-CoA hydratase Sfri_3510 176 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 114563575 Nonpathogen - hypothetical protein Sfri_2405 1 None None None 114563199 Common - threonyl-tRNA synthetase Sfri_2028 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 114562809 Common - hypothetical protein Sfri_1633 1 None None None 114563854 Common - acriflavin resistance protein Sfri_2689 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 114563745 Common - sigma54 specific transcriptional regulator, Fis family protein Sfri_2579 169 COG1221 PspF, Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain Transcription / Signal transduction mechanisms 114561248 Common - rare lipoprotein A Sfri_0060 136 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 114564881 Common - secretion protein HlyD family protein Sfri_3729 122 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 114562234 Common - Pseudouridylate synthase Sfri_1056 86 COG0585 COG0585, Uncharacterized conserved protein Function unknown 114564197 Common - short-chain dehydrogenase/reductase SDR Sfri_3034 225 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 114562932 Common - protein of unknown function UPF0118 Sfri_1757 194 COG0628 PerM, Predicted permease General function prediction only 114562714 Common - heat shock protein 90 Sfri_1538 150 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 114563785 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Sfri_2619 143 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 114563302 Common - 3-demethylubiquinone-9 3-methyltransferase Sfri_2131 145 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 114562832 Nonpathogen - transcriptional regulator, XRE family protein Sfri_1656 1 COG1396 HipB, Predicted transcriptional regulators Transcription 114564604 Common - hypothetical protein Sfri_3448 9 COG5642 COG5642, Uncharacterized conserved protein Function unknown 114563069 Common - iron-containing alcohol dehydrogenase Sfri_1898 196 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 114561750 Common - adenylate cyclase Sfri_0564 59 COG3025 COG3025, Uncharacterized conserved protein Function unknown 114561728 Common - glutathione synthetase Sfri_0542 124 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 114561278 Common - two component transcriptional regulator, winged helix family protein Sfri_0090 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114564047 Common - type IV pilin biogenesis protein, putative Sfri_2883 36 COG3419 PilY1, Tfp pilus assembly protein, tip-associated adhesin PilY1 Cell motility and secretion / Intracellular trafficking and secretion 114561991 Common - putative lipoprotein Sfri_0811 26 COG3489 COG3489, Predicted periplasmic lipoprotein General function prediction only 114561423 Common - RNA binding S1 domain protein Sfri_0235 158 COG2183 Tex, Transcriptional accessory protein Transcription 114564621 Common - transposase Tn3 family protein Sfri_3465 46 COG4644 COG4644, Transposase and inactivated derivatives, TnpA family DNA replication, recombination, and repair 114564802 Common - short-chain dehydrogenase/reductase SDR Sfri_3650 235 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 114562812 Common - hypothetical protein Sfri_1636 10 None None None 114564761 Common - hydroxylamine reductase Sfri_3609 75 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 114561531 Common - hypothetical protein Sfri_0343 40 COG4258 COG4258, Predicted exporter General function prediction only 114563604 Common - putative two-component response-regulatory protein YehT Sfri_2434 198 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 114562645 Nonpathogen - hypothetical protein Sfri_1468 2 None None None 114563142 Common - copper resistance protein CopC Sfri_1971 10 COG2372 CopC, Uncharacterized protein, homolog of Cu resistance protein CopC General function prediction only 114564692 Nonpathogen - hypothetical protein Sfri_3540 1 None None None 114562049 Common - hypothetical protein Sfri_0871 3 None None None 114562667 Common - pseudouridine synthase, RluA family protein Sfri_1491 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 114564724 Nonpathogen - hypothetical protein Sfri_3572 1 None None None 114564851 Common - globin Sfri_3699 142 COG1017 Hmp, Hemoglobin-like flavoprotein Energy production and conversion 114561817 Common - hypothetical protein Sfri_0632 1 None None None 114562144 Common - gamma-glutamyl kinase Sfri_0966 189 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 114563366 Common - conserved hypothetical methyl-accepting chemotaxis protein Sfri_2195 1 None None None 114564729 Common - hypothetical protein Sfri_3577 24 None None None 114561535 Common - glycosyl transferase, family 2 Sfri_0347 136 COG4261 COG4261, Predicted acyltransferase General function prediction only 114562248 Common - hypothetical protein Sfri_1070 80 COG1238 COG1238, Predicted membrane protein Function unknown 114562692 Common - Curlin associated repeat protein Sfri_1516 92 None None None 114563163 Common - multi-sensor hybrid histidine kinase Sfri_1992 216 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114563475 Common - thioesterase superfamily protein Sfri_2304 133 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 114563227 Common - haloalkane dehalogenase Sfri_2056 115 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114562902 Common - helicase c2 Sfri_1727 151 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 114564178 Nonpathogen - hypothetical protein Sfri_3015 1 None None None 114563568 Common - hypothetical protein Sfri_2398 7 None None None 114565015 Common - transcriptional regulator, TetR family protein Sfri_3865 91 COG1309 AcrR, Transcriptional regulator Transcription 114563790 Common - MotA/TolQ/ExbB proton channel Sfri_2624 84 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 114562773 Common - hypothetical protein Sfri_1597 10 COG4399 COG4399, Uncharacterized protein conserved in bacteria Function unknown 114563177 Common - protein of unknown function DUF450 Sfri_2006 30 COG4096 HsdR, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 114561675 Common - acetyltransferase, GNAT family protein Sfri_0488 4 None None None 114564955 Common - cell division protein FtsW Sfri_3805 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 114564078 Common - hypothetical protein Sfri_2914 1 COG3671 COG3671, Predicted membrane protein Function unknown 114561958 Common - deoxyribodipyrimidine photolyase-related protein Sfri_0777 59 COG3046 COG3046, Uncharacterized protein related to deoxyribodipyrimidine photolyase General function prediction only 114561406 Common ompR osmolarity response regulator Sfri_0218 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114562328 Common - hypothetical protein Sfri_1150 2 None None None 114564398 Common - AzlC family protein Sfri_3237 104 COG1296 AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) Amino acid transport and metabolism 114562330 Common - hypothetical protein Sfri_1152 4 None None None 114565199 Common - F0F1 ATP synthase subunit B Sfri_4049 156 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 114564269 Common - PfkB domain protein Sfri_3107 138 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 114565158 Common - TonB-dependent receptor, plug Sfri_4008 121 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 114562307 Common - periplasmic sensor signal transduction histidine kinase Sfri_1129 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114564414 Common - putative nitric oxide reductase (subunit B) transmembrane protein Sfri_3253 72 COG3256 NorB, Nitric oxide reductase large subunit Inorganic ion transport and metabolism 114563902 Nonpathogen - putative monovalent cation/H+ antiporter subunit G Sfri_2737 7 COG1320 MnhG, Multisubunit Na+/H+ antiporter, MnhG subunit Inorganic ion transport and metabolism 114561934 Common - hypothetical protein Sfri_0752 3 None None None 114564120 Common - TonB-dependent receptor Sfri_2956 53 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 114561779 Common - hypothetical protein Sfri_0593 4 None None None 114563815 Common - response regulator Sfri_2649 213 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 114561486 Nonpathogen - hypothetical protein Sfri_0298 1 None None None 114562011 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) Sfri_0833 202 COG0281 SfcA, Malic enzyme Energy production and conversion 114564651 Common - thiopurine S-methyltransferase Sfri_3498 30 None None None 114561553 Common - Guanylate kinase Sfri_0365 214 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 114564003 Common - glycosyl transferase, family 2 Sfri_2839 77 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 114564734 Common - hypothetical protein Sfri_3582 1 None None None 114561335 Common - ribosomal protein S10 Sfri_0147 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 114561294 Common - general secretory pathway protein E Sfri_0106 216 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 114561225 Common - carbonic anhydrase, family 3 Sfri_0037 190 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 114564387 Common - hypothetical protein Sfri_3226 1 None None None 114562411 Nonpathogen - lipoprotein, putative Sfri_1233 4 None None None 114563740 Common - hypothetical protein Sfri_2574 41 COG3768 COG3768, Predicted membrane protein Function unknown 114562326 Common - efflux transporter, RND family, MFP subunit Sfri_1148 151 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 114562685 Common - nitrite reductase (NAD(P)H), large subunit Sfri_1509 200 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 114564911 Common - hypothetical protein Sfri_3759 7 COG3170 FimV, Tfp pilus assembly protein FimV Cell motility and secretion / Intracellular trafficking and secretion 114563735 Common - hypothetical protein Sfri_2569 3 None None None 114562219 Common - Phosphatidylglycerophosphatase Sfri_1041 105 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 114563560 Common - hypothetical protein Sfri_2390 46 COG3216 COG3216, Uncharacterized protein conserved in bacteria Function unknown 114563070 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Sfri_1899 149 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 114562089 Common - Pseudouridine synthase, Rsu Sfri_0911 164 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 114564987 Common - hypothetical protein Sfri_3837 137 COG1561 COG1561, Uncharacterized stress-induced protein Function unknown 114561978 Common - hypothetical protein Sfri_0798 1 None None None 114562360 Common fliF flagellar MS-ring protein Sfri_1182 126 COG1766 FliF, Flagellar biosynthesis/type III secretory pathway lipoprotein Cell motility and secretion / Intracellular trafficking and secretion 114563481 Common - Carboxylesterase Sfri_2310 92 COG0400 COG0400, Predicted esterase General function prediction only 114561345 Common - ribosomal protein S17 Sfri_0157 239 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 114564558 Common uvrD DNA-dependent helicase II Sfri_3397 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 114561218 Common - coproporphyrinogen III oxidase Sfri_0030 113 COG0408 HemF, Coproporphyrinogen III oxidase Coenzyme metabolism 114565041 Common - putative transcriptional regulator, TetR family protein Sfri_3891 1 COG1309 AcrR, Transcriptional regulator Transcription 114565091 Common - Rhomboid family protein Sfri_3941 67 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 114562210 Common - putative ABC transporter ATP-binding protein Sfri_1032 248 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 114565034 Nonpathogen - protein of unknown function DUF47 Sfri_3884 10 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 114562987 Common - protein of unknown function DUF214 Sfri_1812 170 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 114563326 Common - peptidase S9, prolyl oligopeptidase active site domain protein Sfri_2155 126 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 114563959 Common - FAD linked oxidase domain protein Sfri_2794 197 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 114563710 Common - Alkaline phosphatase Sfri_2543 88 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 114565082 Nonpathogen - ADP-heptose:LPS heptosyltransferase-like protein Sfri_3932 2 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 114564636 Common - phage integrase family protein Sfri_3481 8 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 114562977 Common - DsrE family protein Sfri_1802 37 COG2923 DsrF, Uncharacterized protein involved in the oxidation of intracellular sulfur Inorganic ion transport and metabolism 114563330 Common - phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I Sfri_2159 238 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 114562633 Common - ribonuclease T Sfri_1456 89 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 114563129 Common - Endothelin-converting enzyme 1 Sfri_1958 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 114564961 Common - cell division protein FtsL Sfri_3811 23 COG3116 FtsL, Cell division protein Cell division and chromosome partitioning 114563173 Common - hypothetical protein Sfri_2002 1 None None None 114563964 Common - hypothetical protein Sfri_2799 1 None None None 114561944 Common - gamma-glutamyl kinase Sfri_0763 189 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 114563256 Common - ATPase involved in DNA repair-like protein Sfri_2085 71 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 114563503 Common - hypothetical protein Sfri_2332 13 None None None 114564699 Common metF 5,10-methylenetetrahydrofolate reductase Sfri_3547 143 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 114562746 Common - hypothetical protein Sfri_1570 2 None None None 114562239 Common - DNA mismatch repair protein Sfri_1061 205 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 114562333 Common - hypothetical protein Sfri_1155 19 None None None 114562613 Common - acriflavin resistance protein Sfri_1436 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 114561446 Common - cytochrome c oxidase, subunit II Sfri_0258 160 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 114561382 Common - argininosuccinate synthase Sfri_0194 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 114565070 Common - molybdopterin-guanine dinucleotide biosynthesis protein A Sfri_3920 106 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 114564516 Common - ribonuclease R Sfri_3355 205 COG0557 VacB, Exoribonuclease R Transcription 114564483 Common - glycerophosphoryl diester phosphodiesterase Sfri_3322 151 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 114562055 Common cobS cobalamin synthase Sfri_0877 104 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 114561253 Common - ZIP zinc transporter family protein Sfri_0065 13 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 114563751 Common - short-chain alcohol dehydrogenase Sfri_2585 25 COG3007 COG3007, Uncharacterized paraquat-inducible protein B Function unknown 114562102 Common - leucyl aminopeptidase Sfri_0924 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 114561389 Common - cytochrome c, class I Sfri_0201 57 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 114562791 Common - Porphyromonas-type peptidyl-arginine deiminase Sfri_1615 87 COG2957 COG2957, Peptidylarginine deiminase and related enzymes Amino acid transport and metabolism 114564596 Common - iron-containing alcohol dehydrogenase Sfri_3439 176 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 114561910 Common - protein of unknown function DUF819 Sfri_0727 24 COG5505 COG5505, Predicted integral membrane protein Function unknown 114561361 Common - DNA-directed RNA polymerase subunit alpha Sfri_0173 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 114562743 Common - peptidase E Sfri_1567 33 COG3340 PepE, Peptidase E Amino acid transport and metabolism 114564972 Common - ATP-dependent DNA helicase RecQ Sfri_3822 238 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 114563033 Common - putative AcnD-accessory protein PrpF Sfri_1860 55 COG2828 COG2828, Uncharacterized protein conserved in bacteria Function unknown 114562824 Common - putative phage repressor Sfri_1648 37 COG2932 COG2932, Predicted transcriptional regulator Transcription 114562920 Common - hypothetical protein Sfri_1745 71 COG2718 COG2718, Uncharacterized conserved protein Function unknown 114562654 Common - Methyltransferase type 11 Sfri_1477 67 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 114565100 Common - alpha/beta hydrolase fold Sfri_3950 148 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114564039 Common - hypothetical protein Sfri_2875 117 COG2353 COG2353, Uncharacterized conserved protein Function unknown 114563460 Nonpathogen - hypothetical protein Sfri_2289 2 None None None 114562571 Common - AAA ATPase containing von Willebrand factor type A (vWA) domain-like protein Sfri_1394 84 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 114564739 Common - efflux transporter, RND family, MFP subunit Sfri_3587 91 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 114561281 Common - diguanylate cyclase Sfri_0093 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114561688 Common - Antibiotic biosynthesis monooxygenase Sfri_0502 19 COG1359 COG1359, Uncharacterized conserved protein Function unknown 114565065 Common - periplasmic sensor signal transduction histidine kinase Sfri_3915 220 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 114564024 Common - Protein of unknown function UPF0001 Sfri_2860 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 114564874 Common - hypothetical protein Sfri_3722 59 COG3028 COG3028, Uncharacterized protein conserved in bacteria Function unknown 114563924 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Sfri_2759 167 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 114562576 Common - amidophosphoribosyltransferase Sfri_1399 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 114563083 Common - hypothetical protein Sfri_1912 8 None None None 114561925 Common - Rh family protein/ammonium transporter Sfri_0742 202 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 114562972 Common - recombination factor protein RarA Sfri_1797 230 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 114562429 Common - hypothetical protein Sfri_1251 12 COG5595 COG5595, Zn-ribbon-containing, possibly nucleic-acid-binding protein General function prediction only 114562404 Common - MotA/TolQ/ExbB proton channel Sfri_1226 18 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 114562564 Nonpathogen - hypothetical protein Sfri_1387 2 None None None 114562432 Common - hypothetical protein Sfri_1254 23 None None None 114563986 Common - phosphoglucosamine mutase Sfri_2822 242 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 114562176 Common - hypothetical protein Sfri_0998 1 None None None 114564304 Common - beta-ribofuranosylaminobenzene 5'-phosphate synthase family protein Sfri_3142 31 COG1907 COG1907, Predicted archaeal sugar kinases General function prediction only 114562984 Common - choline/carnitine/betaine transporter Sfri_1809 95 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 114564087 Common - protein of unknown function DUF21 Sfri_2923 218 COG4536 CorB, Putative Mg2+ and Co2+ transporter CorB Inorganic ion transport and metabolism 114563715 Common - PepSY-associated TM helix domain protein Sfri_2548 50 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 114564470 Common - HflK protein Sfri_3309 189 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 114562300 Nonpathogen - hypothetical protein Sfri_1122 1 None None None 114564843 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sfri_3691 29 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 114561781 Common - protein of unknown function UPF0126 Sfri_0596 133 COG2860 COG2860, Predicted membrane protein Function unknown 114563691 Common - transcriptional repressor, CopY family protein Sfri_2523 27 COG3682 COG3682, Predicted transcriptional regulator Transcription 114563997 Nonpathogen - hypothetical protein Sfri_2833 1 None None None 114562038 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Sfri_0860 103 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 114564566 Common - Diaminopimelate decarboxylase Sfri_3405 213 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 114565069 Common - ABC transporter related Sfri_3919 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 114564332 Common - TonB-dependent receptor Sfri_3171 114 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 114564129 Common - diguanylate phosphodiesterase Sfri_2965 162 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 114562722 Common - hypothetical protein Sfri_1546 53 COG4327 COG4327, Predicted membrane protein Function unknown 114561846 Common - methyltransferase small Sfri_0661 56 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 114562158 Common secF preprotein translocase subunit SecF Sfri_0980 214 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 114563101 Common - efflux transporter, RND family, MFP subunit Sfri_1930 127 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 114563376 Common - ribonuclease H Sfri_2205 175 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 114564393 Common - ABC transporter related Sfri_3232 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 114561646 Common rho transcription termination factor Rho Sfri_0459 201 COG1158 Rho, Transcription termination factor Transcription 114564505 Common - CheC domain protein Sfri_3344 27 COG1406 COG1406, Predicted inhibitor of MCP methylation, homolog of CheC Cell motility and secretion 114564202 Common - Protein of unknown function DUF1722 Sfri_3039 55 COG3272 COG3272, Uncharacterized conserved protein Function unknown 114563843 Common - ATPase associated with various cellular activities, AAA_3 Sfri_2678 180 COG0714 COG0714, MoxR-like ATPases General function prediction only 114562566 Common - UTP-glucose-1-phosphate uridylyltransferase Sfri_1389 230 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 114564670 Common - hypothetical protein Sfri_3517 15 None None None 114564118 Common - iron permease FTR1 Sfri_2954 85 COG0672 FTR1, High-affinity Fe2+/Pb2+ permease Inorganic ion transport and metabolism 114561657 Common - Sec-independent protein translocase, TatC subunit Sfri_0470 205 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 114563299 Common - O-methyltransferase, putative Sfri_2128 16 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 114563881 Common - Tripartite ATP-independent periplasmic transporter, DctQ component Sfri_2716 42 COG3090 DctM, TRAP-type C4-dicarboxylate transport system, small permease component Carbohydrate transport and metabolism 114562222 Common - Auxin Efflux Carrier Sfri_1044 120 COG0679 COG0679, Predicted permeases General function prediction only 114563599 Common - phosphate-starvation-inducible E Sfri_2429 21 COG3223 COG3223, Predicted membrane protein Function unknown 114562367 Common fliM flagellar motor switch protein FliM Sfri_1189 113 COG1868 FliM, Flagellar motor switch protein Cell motility and secretion 114563390 Common - protein of unknown function DUF1379 Sfri_2219 16 None None None 114561432 Common - predicted gluconate transport-associated protein Sfri_0244 68 COG0694 COG0694, Thioredoxin-like proteins and domains Posttranslational modification, protein turnover, chaperones 114563348 Common - SoxR-reducing system protein RsxE Sfri_2177 76 COG4660 RnfE, Predicted NADH:ubiquinone oxidoreductase, subunit RnfE Energy production and conversion 114564613 Common - heavy metal efflux pump, CzcA family protein Sfri_3457 178 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 114562126 Common - TonB-dependent receptor C-terminal region domain lipoprotein Sfri_0948 11 COG4772 FecA, Outer membrane receptor for Fe3+-dicitrate Inorganic ion transport and metabolism 114563829 Common - tRNA/rRNA methyltransferase (SpoU) Sfri_2663 20 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 114565136 Common - transporter, hydrophobe/amphiphile efflux-1 (HAE1) family protein Sfri_3986 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 114563009 Common - putative branched-chain amino acid ABC transporter, periplasmic branched-chain amino acid-binding protein Sfri_1835 49 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 114562620 Common - protein of unknown function DUF490 Sfri_1443 103 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 114565189 Common - protein of unknown function DUF450 Sfri_4039 41 COG4748 COG4748, Uncharacterized conserved protein Function unknown 114562583 Common - Antibiotic biosynthesis monooxygenase Sfri_1406 33 COG1359 COG1359, Uncharacterized conserved protein Function unknown 114561704 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Sfri_0518 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 114563319 Common - hypothetical protein Sfri_2148 4 None None None 114561726 Common - rRNA (guanine-N(2)-)-methyltransferase Sfri_0540 106 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 114565048 Nonpathogen - hypothetical protein Sfri_3898 2 None None None 114562362 Common fliH flagellar assembly protein H Sfri_1184 46 COG1317 FliH, Flagellar biosynthesis/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 114564841 Common - periplasmic sensor signal transduction histidine kinase Sfri_3689 225 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 114563312 Nonpathogen - hypothetical protein Sfri_2141 2 None None None 114564930 Common pdhR transcriptional regulator PdhR Sfri_3778 144 COG2186 FadR, Transcriptional regulators Transcription 114562392 Common - methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor Sfri_1214 164 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114563211 Common - TonB-dependent receptor Sfri_2040 110 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 114564110 Common - DNA mismatch repair protein Sfri_2946 29 COG3066 MutH, DNA mismatch repair protein DNA replication, recombination, and repair 114563531 Common - protein of unknown function DUF796 Sfri_2361 22 COG3157 Hcp, Hemolysin-coregulated protein (uncharacterized) Function unknown 114561515 Common - methylation site containing protein Sfri_0327 5 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 114564019 Common - type II secretion system protein E Sfri_2855 195 COG5008 PilU, Tfp pilus assembly protein, ATPase PilU Cell motility and secretion / Intracellular trafficking and secretion 114563387 Common - aminoglycoside phosphotransferase Sfri_2216 60 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 114564260 Common - lipid A ABC exporter family, fused ATPase and inner membrane subunits Sfri_3098 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 114561648 Common - ATP-dependent RNA helicase RhlB Sfri_0461 238 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 114561316 Common - hypothetical protein Sfri_0128 3 None None None 114562891 Common hisH imidazole glycerol phosphate synthase subunit HisH Sfri_1716 216 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 114561408 Common - protoheme IX farnesyltransferase Sfri_0220 169 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 114563623 Common - protein of unknown function DUF81 Sfri_2453 179 COG0730 COG0730, Predicted permeases General function prediction only 114564453 Common - cAMP-regulatory protein Sfri_3292 167 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 114561856 Common - CDP-diacylglycerol--serine O-phosphatidyltransferase Sfri_0671 148 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 114562302 Common - Redoxin domain protein Sfri_1124 162 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 114562559 Common - sugar transferase Sfri_1382 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 114562487 Common - tryptophan halogenase Sfri_1309 16 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 114564395 Common - aromatic acid decarboxylase Sfri_3234 152 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 114565077 Common - glycosyl transferase, family 25 Sfri_3927 33 COG3306 COG3306, Glycosyltransferase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 114561936 Common - transposase IS3/IS911 family protein Sfri_0754 50 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 114564538 Common - RNA polymerase factor sigma-54 Sfri_3377 145 COG1508 RpoN, DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog Transcription 114563616 Common - hypothetical protein Sfri_2446 11 None None None 114563768 Common - tRNA hydroxylase Sfri_2602 40 COG4445 MiaE, Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 114564541 Common - hypothetical protein Sfri_3380 140 COG1660 COG1660, Predicted P-loop-containing kinase General function prediction only 114564899 Common - type II secretion system protein Sfri_3747 149 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 114562549 Common - diguanylate cyclase/phosphodiesterase Sfri_1371 145 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 114564864 Common - excinuclease ABC, A subunit Sfri_3712 237 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 114563693 Common - hypothetical protein Sfri_2525 3 None None None 114562882 Common - Endonuclease/exonuclease/phosphatase Sfri_1707 59 COG2374 COG2374, Predicted extracellular nuclease General function prediction only 114562229 Common - CTP synthetase Sfri_1051 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 114564790 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Sfri_3638 131 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 114563219 Common - L-sorbosone dehydrogenase, putative Sfri_2048 73 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 114564826 Common - putative sulfate transporter YchM Sfri_3674 159 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 114562309 Common - periplasmic sensor signal transduction histidine kinase Sfri_1131 217 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114561892 Common - apolipoprotein N-acyltransferase Sfri_0709 164 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 114563822 Common - 3-hydroxydecanoyl-(acyl carrier protein) dehydratase Sfri_2656 83 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 114561793 Common - DEAD/DEAH box helicase domain protein Sfri_0608 234 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 114561682 Common - permease Sfri_0495 94 COG0701 COG0701, Predicted permeases General function prediction only 114564357 Common - diguanylate cyclase with PAS/PAC sensor Sfri_3196 183 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114562864 Common - hypothetical protein Sfri_1688 1 None None None 114564029 Common - non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family protein Sfri_2865 237 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 114563392 Common - NAD-glutamate dehydrogenase Sfri_2221 77 COG2902 COG2902, NAD-specific glutamate dehydrogenase Amino acid transport and metabolism 114565182 Common - methyl-accepting chemotaxis sensory transducer Sfri_4032 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114565105 Common - imidazolonepropionase Sfri_3955 104 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 114564348 Common - sulfate adenylyltransferase subunit 2 Sfri_3187 136 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 114561844 Common - efflux transporter, RND family, MFP subunit Sfri_0659 94 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 114562257 Common - hypothetical protein Sfri_1079 1 None None None 114562025 Common - methyl-accepting chemotaxis sensory transducer Sfri_0847 142 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114562204 Common - conserved hypothetical amino acid ABC transporter Sfri_1026 13 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 114562676 Common - acyl carrier protein Sfri_1500 176 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 114562402 Nonpathogen - sigma-70 factor Sfri_1224 7 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 114562700 Common - thioesterase superfamily protein Sfri_1524 28 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 114563404 Common - Paraquat-inducible protein A Sfri_2233 54 COG2995 PqiA, Uncharacterized paraquat-inducible protein A Function unknown 114563448 Common - oxidoreductase domain protein Sfri_2277 136 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 114561623 Common - putative outer membrane adhesin like proteiin Sfri_0436 165 None None None 114564783 Common - hypothetical protein Sfri_3631 1 None None None 114564432 Common - ATP-dependent helicase HrpB Sfri_3271 134 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 114564429 Common - hypothetical protein Sfri_3268 6 None None None 114564063 Common - OmpA/MotB domain protein Sfri_2899 156 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 114562462 Common - Ribonuclease H Sfri_1284 230 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 114561488 Common - hypothetical protein Sfri_0300 1 None None None 114563900 Common - cation antiporter Sfri_2735 27 COG1863 MnhE, Multisubunit Na+/H+ antiporter, MnhE subunit Inorganic ion transport and metabolism 114562627 Common cysB transcriptional regulator CysB Sfri_1450 186 COG0583 LysR, Transcriptional regulator Transcription 114561236 Common - Chorismate lyase Sfri_0048 47 COG3161 UbiC, 4-hydroxybenzoate synthetase (chorismate lyase) Coenzyme metabolism 114562927 Common - hypothetical protein Sfri_1752 4 None None None 114564996 Nonpathogen - hypothetical protein Sfri_3846 1 None None None 114564187 Common - protein of unknown function DUF861, cupin_3 Sfri_3024 30 COG3450 COG3450, Predicted enzyme of the cupin superfamily General function prediction only 114561441 Common - hypothetical protein Sfri_0253 36 COG3346 COG3346, Uncharacterized conserved protein Function unknown 114563031 Common - 2-methylcitrate synthase/citrate synthase II Sfri_1858 194 COG0372 GltA, Citrate synthase Energy production and conversion 114561734 Common - Carbamoyl-phosphate synthase L chain, ATP-binding Sfri_0548 231 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 114563368 Common thiG thiazole synthase Sfri_2197 166 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 114565117 Common - hypothetical protein Sfri_3967 1 None None None 114563498 Common - 4-hydroxyphenylpyruvate dioxygenase Sfri_2327 76 COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins Amino acid transport and metabolism / General function prediction only 114561885 Common - nicotinate (nicotinamide) nucleotide adenylyltransferase Sfri_0702 191 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 114562605 Common - glutamine amidotransferase of anthranilate synthase Sfri_1428 232 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 114563582 Common - hypothetical protein Sfri_2412 62 COG3220 COG3220, Uncharacterized protein conserved in bacteria Function unknown 114563935 Common rdgC recombination associated protein Sfri_2770 53 COG2974 RdgC, DNA recombination-dependent growth factor C DNA replication, recombination, and repair 114563652 Common - Lysine exporter protein (LYSE/YGGA) Sfri_2482 117 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 114562527 Common - ABC transporter related Sfri_1349 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 114565003 Common - transcriptional regulator, AraC family protein Sfri_3853 72 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 114563922 Common - hypothetical protein Sfri_2757 8 COG3015 CutF, Uncharacterized lipoprotein NlpE involved in copper resistance Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism 114565147 Common - sigma54 specific transcriptional regulator, Fis family protein Sfri_3997 172 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 114563237 Common - acyl-CoA dehydrogenase domain protein Sfri_2066 144 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 114564619 Common - lipoprotein signal peptidase Sfri_3463 199 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 114564989 Common - peptidase S15 Sfri_3839 72 COG2936 COG2936, Predicted acyl esterases General function prediction only 114561229 Common - adenosine deaminase Sfri_0041 116 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 114564055 Common - riboflavin biosynthesis protein RibF Sfri_2891 211 COG0196 RibF, FAD synthase Coenzyme metabolism 114564640 Common - RNA-directed DNA polymerase Sfri_3486 86 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 114562842 Common - Uncharacterized phage-encoded protein-like protein Sfri_1666 23 COG3646 COG3646, Uncharacterized phage-encoded protein Function unknown 114562358 Common - two component, sigma54 specific, transcriptional regulator, Fis family protein Sfri_1180 181 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 114564979 Common - phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase Sfri_3829 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 114564943 Common - ISSod10, transposase OrfA Sfri_3793 25 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 114563984 Common - beta-lactamase domain protein Sfri_2820 125 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 114561491 Common - peptidase M16 domain protein Sfri_0303 201 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 114564573 Common - NERD domain protein Sfri_3412 7 COG3318 COG3318, Predicted metal-binding protein related to the C-terminal domain of SecA General function prediction only 114563590 Common hscA chaperone protein HscA Sfri_2420 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 114564964 Common - hypothetical protein Sfri_3814 1 None None None 114562892 Common - imidazole glycerol-phosphate dehydratase/histidinol phosphatase Sfri_1717 219 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 114561267 Common - hypothetical protein Sfri_0079 12 COG3296 COG3296, Uncharacterized protein conserved in bacteria Function unknown 114561797 Common - 2OG-Fe(II) oxygenase Sfri_0612 45 COG3128 PiuC, Uncharacterized iron-regulated protein Function unknown 114563633 Common - chromosome segregation protein SMC Sfri_2463 179 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 114563977 Common - multi-sensor hybrid histidine kinase Sfri_2813 224 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114564914 Common argS arginyl-tRNA synthetase Sfri_3762 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 114562456 Common - surface antigen (D15) Sfri_1278 159 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 114561303 Common - type II secretion system protein N Sfri_0115 13 None None None 114564514 Common - major facilitator superfamily MFS_1 Sfri_3353 64 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 114563805 Common - outer membrane protein precursor MtrB Sfri_2639 9 None None None 114565204 Common - Cobyrinic acid a,c-diamide synthase Sfri_4054 227 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 114564345 Common - Adenylyl-sulfate kinase Sfri_3184 145 COG0529 CysC, Adenylylsulfate kinase and related kinases Inorganic ion transport and metabolism 114561483 Nonpathogen - hypothetical protein Sfri_0295 1 None None None 114562484 Common - DTW domain containing protein Sfri_1306 36 COG3148 COG3148, Uncharacterized conserved protein Function unknown 114562084 Common - hypothetical protein Sfri_0906 24 COG3686 COG3686, Predicted membrane protein Function unknown 114561498 Common - periplasmic sensor signal transduction histidine kinase Sfri_0310 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114564163 Common - protein of unknown function DUF599 Sfri_3000 27 COG3821 COG3821, Predicted membrane protein Function unknown 114561343 Common rplP 50S ribosomal protein L16 Sfri_0155 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 114561927 Common - hypothetical protein Sfri_0745 60 COG2128 COG2128, Uncharacterized conserved protein Function unknown 114563261 Common - hypothetical protein Sfri_2090 10 None None None 114564248 Common - protein of unknown function DUF1212 Sfri_3086 50 COG2966 COG2966, Uncharacterized conserved protein Function unknown 114563013 Common - hypothetical protein Sfri_1839 16 COG3305 COG3305, Predicted membrane protein Function unknown 114561397 Common - transcriptional regulator, LysR family protein Sfri_0209 178 COG0583 LysR, Transcriptional regulator Transcription 114565175 Common - protein of unknown function UPF0153 Sfri_4025 36 None None None 114562344 Common flgG flagellar basal body rod protein FlgG Sfri_1166 126 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 114561776 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Sfri_0590 196 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114562289 Common - metallophosphoesterase Sfri_1111 124 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 114561752 Common - phosphate transporter Sfri_0566 173 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 114563426 Common - ATP-dependent Clp protease adaptor protein ClpS Sfri_2255 121 COG2127 COG2127, Uncharacterized conserved protein Function unknown 114563063 Common - glucose-6-phosphate 1-dehydrogenase Sfri_1892 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 114562061 Common - Aldehyde dehydrogenase (NAD(+)) Sfri_0883 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 114564645 Common - transcriptional regulator, MerR family protein Sfri_3492 132 COG0789 SoxR, Predicted transcriptional regulators Transcription 114563865 Common secD preprotein translocase subunit SecD Sfri_2700 208 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 114564707 Common - hypothetical protein Sfri_3555 9 None None None 114565027 Common - glutathione reductase Sfri_3877 242 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 114563078 Common - aminotransferase AlaT Sfri_1907 239 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 114563552 Common - acriflavin resistance protein Sfri_2382 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 114564703 Common - O-succinylhomoserine (thiol)-lyase Sfri_3551 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 114563433 Common - adenylosuccinate lyase Sfri_2262 232 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 114561877 Common - hypothetical protein Sfri_0694 30 COG2921 COG2921, Uncharacterized conserved protein Function unknown 114562439 Common - protein of unknown function DUF446 Sfri_1261 32 COG3098 COG3098, Uncharacterized protein conserved in bacteria Function unknown 114564628 Common - prevent-host-death family protein Sfri_3472 9 COG4118 Phd, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 114564339 Common - GCN5-related N-acetyltransferase Sfri_3178 70 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 114561460 Common - NapC/NirT cytochrome c domain protein Sfri_0272 46 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 114564180 Common - Integrase, catalytic region Sfri_3017 143 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 114563708 Nonpathogen - putative orphan protein Sfri_2541 3 None None None 114563947 Common - hypothetical protein Sfri_2782 28 COG3571 COG3571, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 114563810 Common - transposase IS116/IS110/IS902 family protein Sfri_2644 91 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 114561194 Common glyS glycyl-tRNA synthetase subunit beta Sfri_0006 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 114563277 Common - hydrogenase maturation protease Sfri_2106 66 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 114563104 Common - peptide methionine sulfoxide reductase Sfri_1933 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 114564928 Common - pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase Sfri_3776 197 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 114563161 Common - DNA-binding response regulator in two-component regulatory system with TorS Sfri_1990 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114563839 Common - hypothetical protein Sfri_2673 3 None None None 114562440 Common - Pseudouridylate synthase Sfri_1262 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 114564254 Common - methylation site containing protein Sfri_3092 2 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 114562875 Common - Adenosylmethionine decarboxylase Sfri_1699 2 None None None 114561475 Common - hypothetical protein Sfri_0287 5 None None None 114564326 Common - hypothetical protein Sfri_3165 48 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114565211 Common - DNA polymerase III, epsilon subunit Sfri_4061 191 COG2176 PolC, DNA polymerase III, alpha subunit (gram-positive type) DNA replication, recombination, and repair 114562192 Common - peptidase U32 Sfri_1014 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 114565196 Common - F0F1 ATP synthase subunit gamma Sfri_4046 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 114562091 Common - decaheme cytochrome c Sfri_0913 7 None None None 114564405 Common - aminopeptidase N Sfri_3244 168 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 114563848 Common - hypothetical protein Sfri_2683 23 None None None 114564173 Common - putative aminotransferase Sfri_3010 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 114561410 Common - cytochrome c oxidase, subunit III Sfri_0222 159 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 114564301 Common - isocitrate lyase Sfri_3139 111 COG2224 AceA, Isocitrate lyase Energy production and conversion 114563889 Common - 6-phosphogluconate dehydrogenase Sfri_2724 154 COG0362 Gnd, 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 114564292 Common - cytochrome C family protein Sfri_3130 39 None None None 114561743 Common - glycine cleavage T protein (aminomethyl transferase) Sfri_0557 113 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 114562040 Common - acetyl-CoA hydrolase/transferase Sfri_0862 101 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 114562430 Common - hypothetical protein Sfri_1252 4 None None None 114564520 Common rpsI 30S ribosomal protein S9 Sfri_3359 249 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 114564289 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Sfri_3127 165 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 114564581 Common - transcriptional regulator, XRE family protein Sfri_3420 31 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 114561759 Common - hypothetical protein Sfri_0573 21 None None None 114563538 Common - protein of unknown function DUF877 Sfri_2368 50 COG3517 COG3517, Uncharacterized protein conserved in bacteria Function unknown 114565055 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Sfri_3905 77 COG0348 NapH, Polyferredoxin Energy production and conversion 114564797 Nonpathogen - putative lipoprotein Sfri_3645 5 None None None 114562955 Common - major facilitator superfamily MFS_1 Sfri_1780 65 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 114563058 Common - Peptidyl-dipeptidase A Sfri_1887 16 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 114562550 Common - hypothetical protein Sfri_1372 35 COG3672 COG3672, Predicted periplasmic protein Function unknown 114564494 Common - hypothetical protein Sfri_3333 17 None None None 114561636 Common - putative transcriptional regulator Sfri_0449 13 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 114564772 Nonpathogen - hypothetical protein Sfri_3620 3 None None None 114563685 Common - cation diffusion facilitator family transporter Sfri_2517 131 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 114562124 Common - TRAP dicarboxylate transporter- DctP subunit Sfri_0946 89 COG4663 FcbT1, TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 114562296 Common - hypothetical protein Sfri_1118 61 COG2976 COG2976, Uncharacterized protein conserved in bacteria Function unknown 114563577 Common - DNA polymerase III, subunits gamma and tau Sfri_2407 248 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 114564219 Common - F0F1 ATP synthase subunit alpha Sfri_3056 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 114562286 Common - hypothetical protein Sfri_1108 42 COG3530 COG3530, Uncharacterized protein conserved in bacteria Function unknown 114565167 Common - HI0933 family protein Sfri_4017 136 COG2081 COG2081, Predicted flavoproteins General function prediction only 114563026 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Sfri_1853 94 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 114562683 Common - glycosyl transferase, family 3 Sfri_1507 59 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 114563916 Common - protein of unknown function UPF0066 Sfri_2751 93 COG1720 COG1720, Uncharacterized conserved protein Function unknown 114562188 Common - DNA repair protein RadA Sfri_1010 213 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 114564372 Common - Na(+)-translocating NADH-quinone reductase subunit A Sfri_3211 39 COG1726 NqrA, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA Energy production and conversion 114564212 Common - F0F1 ATP synthase subunit beta Sfri_3049 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 114563245 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Sfri_2074 199 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114561577 Common - LppC family lipoprotein Sfri_0389 43 COG3107 LppC, Putative lipoprotein General function prediction only 114564440 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Sfri_3279 200 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 114562506 Common phhA phenylalanine 4-monooxygenase Sfri_1328 45 COG3186 COG3186, Phenylalanine-4-hydroxylase Amino acid transport and metabolism 114564109 Common - dinucleoside polyphosphate hydrolase Sfri_2945 113 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 114562603 Common - bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase Sfri_1426 220 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 114563204 Common - iron-containing alcohol dehydrogenase Sfri_2033 169 COG1979 COG1979, Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family Energy production and conversion 114561419 Common - putative integral membrane protein Sfri_0231 40 COG3647 COG3647, Predicted membrane protein Function unknown 114564134 Common - hypothetical protein Sfri_2970 1 None None None 114561558 Common - type IV pilus assembly protein PilM Sfri_0370 81 COG4972 PilM, Tfp pilus assembly protein, ATPase PilM Cell motility and secretion / Intracellular trafficking and secretion 114564489 Common - protein of unknown function UPF0227 Sfri_3328 47 COG3150 COG3150, Predicted esterase General function prediction only 114561808 Common - nitrogen regulatory protein P-II Sfri_0623 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 114564686 Common - hypothetical protein Sfri_3534 1 None None None 114564838 Common - cytochrome C family protein Sfri_3686 37 None None None 114561993 Common - Protoporphyrinogen oxidase Sfri_0813 31 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 114564184 Common - Aldehyde dehydrogenase (NAD(+)) Sfri_3021 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 114563981 Common - peptidase S9, prolyl oligopeptidase active site domain protein Sfri_2817 107 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 114563451 Common - hypothetical protein Sfri_2280 2 None None None 114563789 Common - Biopolymer transport protein ExbD/TolR Sfri_2623 117 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 114562385 Common - CheW protein Sfri_1207 139 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 114563175 Common - hypothetical protein Sfri_2004 6 None None None 114563856 Common - Rhodanese domain protein Sfri_2691 141 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 114562834 Common - putative esterase Sfri_1658 48 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 114564449 Common - alpha/beta hydrolase fold Sfri_3288 69 COG0429 COG0429, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 114562836 Nonpathogen - hypothetical protein Sfri_1660 1 None None None 114564468 Common - ubiquinol-cytochrome c reductase, iron-sulfur subunit Sfri_3307 95 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 114563830 Common - hypothetical protein Sfri_2664 4 None None None 114561216 Common - DNA topoisomerase, type IA, zn finger domain protein Sfri_0028 138 COG0551 TopA, Zn-finger domain associated with topoisomerase type I DNA replication, recombination, and repair 114564690 Common - ABC transporter related Sfri_3538 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 114562574 Common - Sporulation domain protein Sfri_1397 37 COG3147 DedD, Uncharacterized protein conserved in bacteria Function unknown 114562372 Common fliR flagellar biosynthesis protein FliR Sfri_1194 127 COG1684 FliR, Flagellar biosynthesis pathway, component FliR Cell motility and secretion / Intracellular trafficking and secretion 114565032 Common - phosphate-selective porin O and P Sfri_3882 25 COG3746 OprP, Phosphate-selective porin Inorganic ion transport and metabolism 114562819 Common - hypothetical protein Sfri_1643 1 None None None 114561271 Common moaC molybdenum cofactor biosynthesis protein C Sfri_0083 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 114563224 Common - Integrase, catalytic region Sfri_2053 75 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 114562524 Common - protein of unknown function DUF6, transmembrane Sfri_1346 65 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 114562016 Common - Glutathione S-transferase, N-terminal domain protein Sfri_0838 100 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 114563875 Common - DEAD/DEAH box helicase domain protein Sfri_2710 237 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 114561585 Common - hypothetical protein Sfri_0397 9 None None None 114563861 Common - Rhodanese domain protein Sfri_2696 106 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 114563342 Common - diguanylate cyclase/phosphodiesterase Sfri_2171 161 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 114563812 Nonpathogen - hypothetical protein Sfri_2646 1 None None None 114564508 Common - hypothetical protein Sfri_3347 21 None None None 114562699 Common - uncharacterized domain 1 Sfri_1523 36 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 114561246 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Sfri_0058 179 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 114563293 Common - integration host factor, beta subunit Sfri_2122 205 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 114561337 Common rplD 50S ribosomal protein L4 Sfri_0149 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 114564510 Common rpsR 30S ribosomal protein S18 Sfri_3349 214 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 114561265 Common - PfkB domain protein Sfri_0077 4 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 114561593 Common - hypothetical protein Sfri_0406 1 None None None 114563054 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Sfri_1883 167 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 114561309 Common - putative transcriptional regulator, TetR family protein Sfri_0121 17 COG1309 AcrR, Transcriptional regulator Transcription 114561533 Common - conserved hypothetical 4-hydroxybenzoyl-CoA thioesterase Sfri_0345 62 COG0824 FcbC, Predicted thioesterase General function prediction only 114561555 Common - aminoglycoside phosphotransferase Sfri_0367 19 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 114561783 Nonpathogen - hypothetical protein Sfri_0598 1 None None None 114563144 Common - putative orphan protein Sfri_1973 6 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 114562970 Common - cell divisionFtsK/SpoIIIE Sfri_1795 199 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 114561523 Common - electron transport protein SCO1/SenC Sfri_0335 24 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 114564763 Common - hypothetical protein Sfri_3611 3 None None None 114565165 Common - hypothetical protein Sfri_4015 3 None None None 114565011 Common - lemA protein Sfri_3861 1 None None None 114564766 Nonpathogen - hypothetical protein Sfri_3614 2 None None None 114564977 Common - ribosomal protein L28 Sfri_3827 164 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 114562047 Common - hypothetical protein Sfri_0869 3 None None None 114561815 Common - ABC transporter related Sfri_0630 249 COG5265 ATM1, ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components Posttranslational modification, protein turnover, chaperones 114563722 Common - periplasmic nitrate reductase NapE Sfri_2555 9 COG4459 NapE, Periplasmic nitrate reductase system, NapE component Energy production and conversion 114563747 Common - binding-protein-dependent transport systems inner membrane component Sfri_2581 219 COG4168 SapB, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 114562149 Common - DEAD/DEAH box helicase domain protein Sfri_0971 235 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 114562147 Common - chaperone protein DnaK Sfri_0969 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 114562690 Common - Curlin associated repeat protein Sfri_1514 24 None None None 114562768 Common - hypothetical protein Sfri_1592 1 None None None 114561789 Common - protein of unknown function DUF72 Sfri_0604 85 COG1801 COG1801, Uncharacterized conserved protein Function unknown 114563096 Common - hypothetical protein Sfri_1925 7 None None None 114562142 Common - hypothetical protein Sfri_0964 1 None None None 114561702 Common - hypothetical protein Sfri_0516 1 None None None 114561223 Common - hypothetical protein Sfri_0035 5 None None None 114565004 Common - major facilitator superfamily MFS_1 Sfri_3854 77 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 114561862 Common sdhB succinate dehydrogenase iron-sulfur subunit Sfri_0678 207 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 114564503 Common - hypothetical protein Sfri_3342 1 None None None 114564951 Common - cell division protein FtsA Sfri_3801 188 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 114561899 Common - peptidyl-tRNA hydrolase Sfri_0716 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 114563784 Common - GCN5-related N-acetyltransferase Sfri_2618 83 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 114564697 Common - cytochrome c family protein Sfri_3545 35 COG3258 COG3258, Cytochrome c Energy production and conversion 114563648 Common - DNA topoisomerase I Sfri_2478 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 114562030 Common - anti-ECFsigma factor, ChrR Sfri_0852 32 COG3806 ChrR, Transcriptional activator Transcription 114561598 Common - protein of unknown function DUF1107 Sfri_0411 1 None None None 114564832 Common - haloalkane dehalogenase Sfri_3680 113 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114563513 Common - 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase Sfri_2342 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 114563183 Common - Cbb3-type cytochrome oxidase component Sfri_2012 16 COG4736 CcoQ, Cbb3-type cytochrome oxidase, subunit 3 Posttranslational modification, protein turnover, chaperones 114562078 Common - protein of unknown function DUF214 Sfri_0900 147 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 114561711 Common - hypothetical protein Sfri_0525 63 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 114561896 Common - tRNA-i(6)A37 thiotransferase enzyme MiaB Sfri_0713 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 114562164 Common - Triose-phosphate isomerase Sfri_0986 218 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 114561760 Common - aromatic amino acid permease Sfri_0574 36 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 114562591 Common - (2Fe-2S)-binding domain protein Sfri_1414 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 114563776 Common - plasmid recombination enzyme Sfri_2610 9 None None None 114562802 Common - sortase family protein Sfri_1626 23 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 114563505 Common - Peptidyl-dipeptidase Dcp Sfri_2334 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 114562554 Common - glycosyl transferase, group 1 Sfri_1376 206 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 114564675 Common - MaoC domain protein dehydratase Sfri_3522 25 COG2030 MaoC, Acyl dehydratase Lipid metabolism 114564811 Common - ATPase, putative Sfri_3659 13 None None None 114563137 Common - hypothetical protein Sfri_1966 1 None None None 114562852 Common - hypothetical protein Sfri_1676 3 None None None 114563148 Common - hypothetical protein Sfri_1977 23 None None None 114562958 Common - hypothetical protein Sfri_1783 13 None None None 114564913 Common - primosomal protein N' Sfri_3761 214 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 114561357 Common rpmJ 50S ribosomal protein L36 Sfri_0169 137 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 114563188 Common - hypothetical protein Sfri_2017 65 COG2836 COG2836, Uncharacterized conserved protein Function unknown 114564605 Common - hypothetical protein Sfri_3449 1 None None None 114561917 Common - OmpA domain protein transmembrane region-containing protein Sfri_0734 13 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 114564067 Common - Hemerythrin HHE cation binding domain protein Sfri_2903 13 COG3945 COG3945, Uncharacterized conserved protein Function unknown 114565123 Common - AMP-dependent synthetase and ligase Sfri_3973 215 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 114563799 Common - hypothetical protein Sfri_2633 5 COG3110 COG3110, Uncharacterized protein conserved in bacteria Function unknown 114562094 Common valS valyl-tRNA synthetase Sfri_0916 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 114563526 Nonpathogen - hypothetical protein Sfri_2356 2 None None None 114563817 Common - PKD domain containing protein Sfri_2651 14 None None None 114564282 Common - multi-sensor hybrid histidine kinase Sfri_3120 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114564742 Common - hypothetical protein Sfri_3590 5 None None None 114561849 Common - thiol:disulfide interchange protein DsbC Sfri_0664 68 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 114563545 Common - protein of unknown function DUF876 Sfri_2375 49 COG3522 COG3522, Uncharacterized protein conserved in bacteria Function unknown 114564317 Common - Glycerophosphoryl diester phosphodiesterase-like protein Sfri_3156 3 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 114562587 Common - alpha/beta hydrolase fold Sfri_1410 23 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114561560 Common - Pilus assembly protein, PilO Sfri_0372 48 COG3167 PilO, Tfp pilus assembly protein PilO Cell motility and secretion / Intracellular trafficking and secretion 114562470 Common - diguanylate cyclase Sfri_1292 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114564552 Common - hypothetical protein Sfri_3391 23 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 114564155 Common - hypothetical protein Sfri_2991 165 COG0344 COG0344, Predicted membrane protein Function unknown 114564359 Common - transcriptional regulator, TetR family protein Sfri_3198 3 COG1309 AcrR, Transcriptional regulator Transcription 114564958 Common - UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase Sfri_3808 212 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 114561633 Common - protein of unknown function DUF484 Sfri_0446 22 COG3159 COG3159, Uncharacterized protein conserved in bacteria Function unknown 114563268 Common - short-chain dehydrogenase/reductase SDR Sfri_2097 230 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114563346 Common - electron transport complex, RnfABCDGE type, D subunit Sfri_2175 76 COG4658 RnfD, Predicted NADH:ubiquinone oxidoreductase, subunit RnfD Energy production and conversion 114563043 Common - hypothetical protein Sfri_1871 17 None None None 114564310 Common - glycine dehydrogenase Sfri_3149 172 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 114561769 Common lysS lysyl-tRNA synthetase Sfri_0583 249 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 114562582 Common - Alcohol dehydrogenase, zinc-binding domain protein Sfri_1405 155 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 114563194 Common - hypothetical protein Sfri_2023 91 COG0391 COG0391, Uncharacterized conserved protein Function unknown 114561538 Common - hypothetical protein Sfri_0350 25 COG4648 COG4648, Predicted membrane protein Function unknown 114562660 Common - diacylglycerol kinase Sfri_1483 69 COG0818 DgkA, Diacylglycerol kinase Cell envelope biogenesis, outer membrane 114562939 Common - peptidase M15B and M15C, D,D-carboxypeptidase VanY/endolysins Sfri_1764 30 COG1876 VanY, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 114564411 Common - hypothetical protein Sfri_3250 12 None None None 114562097 Common - transcriptional regulator, LysR family protein Sfri_0919 177 COG0583 LysR, Transcriptional regulator Transcription 114562460 Common - UDP-N-acetylglucosamine acyltransferase Sfri_1282 167 COG1043 LpxA, Acyl- acyl carrier protein 114563289 Common - short chain dehydrogenase Sfri_2118 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114563468 Common - phosphoenolpyruvate synthase Sfri_2297 237 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 114564206 Common - protein of unknown function DUF405 Sfri_3043 56 COG2311 COG2311, Predicted membrane protein Function unknown 114563414 Common dcd deoxycytidine triphosphate deaminase Sfri_2243 146 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 114562637 Common - Biopolymer transport protein ExbD/TolR Sfri_1460 136 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 114564492 Common - Nucleoside diphosphate pyrophosphatase Sfri_3331 76 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 114564284 Common - catalase/peroxidase HPI Sfri_3122 98 COG0376 KatG, Catalase (peroxidase I) Inorganic ion transport and metabolism 114564334 Common - malate dehydrogenase Sfri_3173 192 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 114565128 Common - ABC transporter related Sfri_3978 249 COG4555 NatA, ABC-type Na+ transport system, ATPase component Energy production and conversion / Inorganic ion transport and metabolism 114564098 Common - Anti sigma-E protein RseA domain protein Sfri_2934 25 COG3073 RseA, Negative regulator of sigma E activity Signal transduction mechanisms 114564748 Common - Twin-arginine translocation pathway signal Sfri_3596 56 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 114565062 Common - metal dependent phosphohydrolase Sfri_3912 123 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 114561822 Common - binding-protein-dependent transport systems inner membrane component Sfri_0637 144 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 114561214 Common - DNA protecting protein DprA Sfri_0026 211 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 114562822 Common - hypothetical protein Sfri_1646 12 None None None 114564123 Common - hypothetical protein Sfri_2959 32 COG4134 COG4134, ABC-type uncharacterized transport system, periplasmic component General function prediction only 114562036 Common - cytochrome c, class I Sfri_0858 61 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 114563500 Common - protein of unknown function DUF482 Sfri_2329 81 COG3146 COG3146, Uncharacterized protein conserved in bacteria Function unknown 114563753 Common - porin, Gram-negative type Sfri_2587 24 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 114561604 Common - phospholipid/glycerol acyltransferase Sfri_0417 30 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 114565063 Common - isochorismate synthases Sfri_3913 222 COG1169 MenF, Isochorismate synthase Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism 114563115 Common - hypothetical protein Sfri_1944 35 None None None 114561251 Common - hypothetical protein Sfri_0063 53 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 114563089 Common - diguanylate cyclase/phosphodiesterase Sfri_1918 178 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114561984 Common - Alcohol dehydrogenase, zinc-binding domain protein Sfri_0804 115 COG2130 COG2130, Putative NADP-dependent oxidoreductases General function prediction only 114563683 Common - putative transcriptional regulator, ArsR family protein Sfri_2515 67 COG0640 ArsR, Predicted transcriptional regulators Transcription 114561374 Common - competence/damage-inducible protein CinA Sfri_0186 213 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 114564026 Common - protein of unknown function YGGT Sfri_2862 105 COG0762 COG0762, Predicted integral membrane protein Function unknown 114562656 Common - diguanylate cyclase Sfri_1479 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114564102 Common - protein of unknown function DUF339 Sfri_2938 45 COG2938 COG2938, Uncharacterized conserved protein Function unknown 114561363 Common - cytochrome c-type biogenesis protein CcmE Sfri_0175 92 COG2332 CcmE, Cytochrome c-type biogenesis protein CcmE Posttranslational modification, protein turnover, chaperones 114563462 Common - ATPase, P-type (transporting), HAD superfamily, subfamily IC Sfri_2291 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 114564210 Common - peptidase M24 Sfri_3047 227 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 114562104 Common - permease YjgP/YjgQ family protein Sfri_0926 101 COG0795 COG0795, Predicted permeases General function prediction only 114562776 Common - GCN5-related N-acetyltransferase Sfri_1600 29 None None None 114562923 Common - glutaredoxin-like protein Sfri_1748 126 COG0278 COG0278, Glutaredoxin-related protein Posttranslational modification, protein turnover, chaperones 114561649 Common - Ppx/GppA phosphatase Sfri_0462 178 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 114564816 Common - FxsA cytoplasmic membrane protein Sfri_3664 44 COG3030 FxsA, Protein affecting phage T7 exclusion by the F plasmid General function prediction only 114563131 Common - Mammalian cell entry related domain protein Sfri_1960 30 COG3008 PqiB, Paraquat-inducible protein B General function prediction only 114564905 Common - MSHA biogenesis protein MshJ Sfri_3753 15 None None None 114562561 Common - polysaccharide export protein Sfri_1384 105 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 114562312 Common - hypothetical protein Sfri_1134 4 None None None 114564146 Common - general secretion pathway protein B Sfri_2982 6 None None None 114561663 Common - Arginase/agmatinase/formiminoglutamase Sfri_0476 28 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 114564561 Common - band 7 protein Sfri_3400 218 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 114563584 Common - dihydrouridine synthase, DuS Sfri_2414 210 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 114562477 Common - hypothetical protein Sfri_1299 34 COG2370 HupE, Hydrogenase/urease accessory protein Posttranslational modification, protein turnover, chaperones 114564320 Common - 5-formyltetrahydrofolate cyclo-ligase Sfri_3159 187 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 114562406 Nonpathogen - TPR repeat-containing protein Sfri_1228 5 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 114564166 Common - 4-aminobutyrate aminotransferase Sfri_3003 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 114562241 Common - alanyl-tRNA synthetase Sfri_1063 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 114565102 Common - histidine ammonia-lyase Sfri_3952 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 114564970 Common - 2-isopropylmalate synthase Sfri_3820 216 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 114563851 Common - sodium/proline symporter Sfri_2686 187 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 114563458 Nonpathogen - putative multicomponent Na+:H+ antiporter subunit D Sfri_2287 1 None None None 114563606 Common - hypothetical protein Sfri_2436 37 COG4628 COG4628, Uncharacterized conserved protein Function unknown 114564306 Common - transposase IS3/IS911 family protein Sfri_3144 50 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 114562930 Common - peptidase M48, Ste24p Sfri_1755 127 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 114562217 Common nusB transcription antitermination protein NusB Sfri_1039 194 COG0781 NusB, Transcription termination factor Transcription 114562672 Common - fatty acid/phospholipid synthesis protein Sfri_1496 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 114562724 Common - cyclic nucleotide-binding protein Sfri_1548 191 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 114561503 Common - Dihydrolipoyllysine-residue succinyltransferase Sfri_0315 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 114564391 Common - hypothetical protein Sfri_3230 4 None None None 114562356 Common - sigma54 specific transcriptional regulator, Fis family protein Sfri_1178 170 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 114562171 Common rpsO 30S ribosomal protein S15 Sfri_0993 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 114563970 Common - response regulator receiver protein Sfri_2806 221 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 114564071 Common - peptidylprolyl isomerase, FKBP-type Sfri_2907 119 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 114561575 Common - phosphoheptose isomerase Sfri_0387 123 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 114562237 Common - peptidase M23B Sfri_1059 188 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 114562739 Common - hypothetical protein Sfri_1563 1 None None None 114563728 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sfri_2561 14 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 114564925 Common - Patatin Sfri_3773 136 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 114562981 Nonpathogen - hypothetical protein Sfri_1806 7 None None None 114562020 Common - Endothelin-converting enzyme 1 Sfri_0842 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 114563321 Common - two component transcriptional regulator, winged helix family protein Sfri_2150 209 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114561296 Common - general secretion pathway protein G Sfri_0108 104 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 114563749 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Sfri_2583 249 COG4170 SapD, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 114565076 Common coaD phosphopantetheine adenylyltransferase Sfri_3926 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 114564005 Common - lipopolysaccharide biosynthesis Sfri_2841 10 COG3765 WzzB, Chain length determinant protein Cell envelope biogenesis, outer membrane 114561614 Common - protein of unknown function DUF526 Sfri_0427 52 COG2960 COG2960, Uncharacterized protein conserved in bacteria Function unknown 114564590 Common - NADH dehydrogenase Sfri_3431 160 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 114563792 Common - hypothetical protein Sfri_2626 18 None None None 114564751 Common - hypothetical protein Sfri_3599 8 None None None 114564416 Common - ErfK/YbiS/YcfS/YnhG family protein Sfri_3255 82 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 114562703 Common - hypothetical protein Sfri_1527 9 None None None 114564073 Common - Trp operon repressor Sfri_2909 22 COG2973 TrpR, Trp operon repressor Transcription 114564598 Common - TetR family transcriptional regulator-like protein Sfri_3441 4 None None None 114564518 Common - Adenylosuccinate synthase Sfri_3357 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 114564481 Common - protein of unknown function DUF6, transmembrane Sfri_3320 91 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 114563328 Common - para-aminobenzoate synthase, subunit I Sfri_2157 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 114565018 Common ribB 3,4-dihydroxy-2-butanone 4-phosphate synthase Sfri_3868 229 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 114561686 Common - drug resistance transporter, EmrB/QacA subfamily Sfri_0500 197 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 114563704 Common - hypothetical protein Sfri_2536 5 None None None 114562332 Common - hypothetical protein Sfri_1154 6 None None None 114562996 Common - carbohydrate kinase, YjeF related protein Sfri_1821 216 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 114563737 Common - hypothetical protein Sfri_2571 13 None None None 114562151 Common - peptidylprolyl isomerase, FKBP-type Sfri_0973 131 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 114562759 Common - anaerobic nitric oxide reductase flavorubredoxin Sfri_1583 117 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 114561484 Common - transcriptional regulator, LysR family protein Sfri_0296 99 COG0583 LysR, Transcriptional regulator Transcription 114561765 Common rumB 23S rRNA metyluridine methyltransferase Sfri_0579 169 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 114561777 Common - hypothetical protein Sfri_0591 2 None None None 114562687 Common - nitrite transporter Sfri_1511 84 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 114565180 Common - naphthoate synthase Sfri_4030 174 COG0447 MenB, Dihydroxynaphthoic acid synthase Coenzyme metabolism 114564427 Common - phage shock protein A, PspA Sfri_3266 25 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 114562635 Common - 4-hydroxybenzoyl-CoA thioesterase Sfri_1458 140 COG0824 FcbC, Predicted thioesterase General function prediction only 114562232 Common - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Sfri_1054 190 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 114563518 Common - succinate dehydrogenase, cytochrome b subunit Sfri_2347 91 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 114563171 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Sfri_2000 168 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 114562807 Common - 2OG-Fe(II) oxygenase Sfri_1631 30 COG3751 EGL-9, Predicted proline hydroxylase Posttranslational modification, protein turnover, chaperones 114563566 Common - lipoprotein releasing system, ATP-binding protein Sfri_2396 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 114561951 Common - hypothetical protein Sfri_0770 36 COG4628 COG4628, Uncharacterized conserved protein Function unknown 114562541 Common - protein of unknown function DUF1289 Sfri_1363 11 COG3313 COG3313, Predicted Fe-S protein General function prediction only 114561451 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sfri_0263 44 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 114561202 Common - Xaa-Pro dipeptidase Sfri_0014 180 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 114561998 Common - DSBA oxidoreductase Sfri_0818 41 None None None 114561200 Common fadA 3-ketoacyl-CoA thiolase Sfri_0012 186 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 114561444 Common - cytochrome C oxidase assembly protein Sfri_0256 68 COG3175 COX11, Cytochrome oxidase assembly factor Posttranslational modification, protein turnover, chaperones 114561384 Nonpathogen - hypothetical protein Sfri_0196 5 None None None 114563120 Common - hypothetical protein Sfri_1949 7 None None None 114561670 Nonpathogen - hypothetical protein Sfri_0483 1 None None None 114562886 Common - lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase Sfri_1711 85 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 114564732 Common - TonB-dependent receptor, plug Sfri_3580 25 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 114563966 Common - Threonine aldolase Sfri_2801 88 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 114561677 Common - Na+/H+ antiporter NhaC Sfri_0490 70 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 114562087 Common - hypothetical protein Sfri_0909 6 None None None 114562319 Common - phosphoribosylformylglycinamidine synthase Sfri_1141 232 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 114561391 Nonpathogen - hypothetical protein Sfri_0203 1 None None None 114564982 Common - peptidase S9, prolyl oligopeptidase active site domain protein Sfri_3832 119 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 114563421 Common - 17 kDa surface antigen Sfri_2250 14 COG3133 SlyB, Outer membrane lipoprotein Cell envelope biogenesis, outer membrane 114565157 Common - hypothetical protein Sfri_4007 17 None None None 114562975 Common - DsrC family protein Sfri_1800 60 COG2920 DsrC, Dissimilatory sulfite reductase (desulfoviridin), gamma subunit Inorganic ion transport and metabolism 114563402 Common - YebG family protein Sfri_2231 19 COG3141 COG3141, Uncharacterized protein conserved in bacteria Function unknown 114561327 Common rplJ 50S ribosomal protein L10 Sfri_0139 204 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 114563186 Common - heavy metal translocating P-type ATPase Sfri_2015 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 114562732 Common - hypothetical protein Sfri_1556 4 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 114561283 Nonpathogen - hypothetical protein Sfri_0095 1 None None None 114563274 Common - hydrogenase (NiFe) small subunit HydA Sfri_2103 77 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 114564000 Common - short-chain dehydrogenase/reductase SDR Sfri_2836 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114561755 Common - hypothetical protein Sfri_0569 6 None None None 114561830 Common - GCN5-related N-acetyltransferase Sfri_0645 5 COG2153 ElaA, Predicted acyltransferase General function prediction only 114564327 Common - short-chain dehydrogenase/reductase SDR Sfri_3166 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114562458 Common - UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase Sfri_1280 148 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 114564548 Common - diguanylate cyclase Sfri_3387 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114564259 Common - AMP-dependent synthetase and ligase Sfri_3097 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 114562569 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Sfri_1392 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 114564709 Common - pseudouridine synthase Sfri_3557 211 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 114562866 Nonpathogen - hypothetical protein Sfri_1690 1 None None None 114564007 Common - polysaccharide export protein Sfri_2843 113 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 114564053 Common - lipoprotein signal peptidase Sfri_2889 206 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 114563920 Common - response regulator receiver modulated metal dependent phosphohydrolase Sfri_2755 123 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 114562701 Common - protein of unknown function DUF1425 Sfri_1525 11 COG5633 COG5633, Predicted periplasmic lipoprotein General function prediction only 114563803 Common - decaheme cytochrome c Sfri_2637 8 None None None 114564455 Common - two component transcriptional regulator, winged helix family protein Sfri_3294 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114564065 Common pgi glucose-6-phosphate isomerase Sfri_2901 204 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 114562534 Common - amino acid-binding ACT domain protein Sfri_1356 21 COG2716 GcvR, Glycine cleavage system regulatory protein Amino acid transport and metabolism 114564389 Common - hypothetical protein Sfri_3228 7 None None None 114561238 Common - putative SAM-dependent methyltransferase Sfri_0050 28 COG3129 COG3129, Predicted SAM-dependent methyltransferase General function prediction only 114562793 Nonpathogen - hypothetical protein Sfri_1617 2 None None None 114561638 Common - Kelch repeat protein Sfri_0451 7 COG3055 COG3055, Uncharacterized protein conserved in bacteria Function unknown 114561568 Common - hypothetical protein Sfri_0380 3 None None None 114564719 Common - glycerophosphoryl diester phosphodiesterase Sfri_3567 53 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 114565025 Common - hypothetical protein Sfri_3875 2 None None None 114561625 Common - protein of unknown function DUF513, hemX Sfri_0438 55 COG2959 HemX, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 114562027 Common - MscS Mechanosensitive ion channel Sfri_0849 169 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 114564434 Common - putative 2'-5' RNA ligase Sfri_3273 7 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 114563610 Common - TonB-dependent receptor, plug Sfri_2440 114 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 114563650 Common - Ig domain protein, group 1 domain protein Sfri_2480 39 None None None 114561839 Nonpathogen - hypothetical protein Sfri_0654 1 None None None 114564779 Common - hypothetical protein Sfri_3627 6 None None None 114563003 Common - two component transcriptional regulator, LuxR family protein Sfri_1828 175 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 114564406 Common - Endonuclease/exonuclease/phosphatase Sfri_3245 13 COG2374 COG2374, Predicted extracellular nuclease General function prediction only 114562130 Common - Na(+)-translocating NADH-quinone reductase subunit D Sfri_0952 76 COG1347 NqrD, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD Energy production and conversion 114561920 Common - hypothetical protein Sfri_0737 2 None None None 114561227 Common - alpha/beta hydrolase fold Sfri_0039 88 COG2267 PldB, Lysophospholipase Lipid metabolism 114561438 Common - protoheme IX farnesyltransferase Sfri_0250 178 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 114563197 Common rpmI 50S ribosomal protein L35 Sfri_2026 143 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 114561379 Common argC N-acetyl-gamma-glutamyl-phosphate reductase Sfri_0191 214 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 114563669 Common - Glutathione S-transferase, C-terminal domain protein Sfri_2500 40 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 114564753 Common - transcriptional regulator, HxlR family protein Sfri_3601 94 COG1733 COG1733, Predicted transcriptional regulators Transcription 114565074 Common - formamidopyrimidine-DNA glycosylase Sfri_3924 180 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 114564571 Common - transcriptional regulator, XRE family protein Sfri_3410 42 COG1476 COG1476, Predicted transcriptional regulators Transcription 114561790 Common - hypothetical protein Sfri_0605 15 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 114563030 Common prpB 2-methylisocitrate lyase Sfri_1857 136 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 114561724 Common - hypothetical protein Sfri_0538 3 None None None 114561820 Common - oxidoreductase FAD/NAD(P)-binding domain protein Sfri_0635 105 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 114563592 Common - iron-sulfur cluster assembly protein IscA Sfri_2422 162 COG0316 IscA, Uncharacterized conserved protein Function unknown 114561919 Common - hypothetical protein Sfri_0736 4 None None None 114562949 Common - protein of unknown function DUF805 Sfri_1774 59 COG3152 COG3152, Predicted membrane protein Function unknown 114561313 Common - tRNA (uracil-5-)-methyltransferase Sfri_0125 162 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 114563310 Common - protein of unknown function RIO1 Sfri_2139 66 COG1718 RIO1, Serine/threonine protein kinase involved in cell cycle control Signal transduction mechanisms / Cell division and chromosome partitioning 114564923 Common - bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase Sfri_3771 217 COG1049 AcnB, Aconitase B Energy production and conversion 114564994 Common - hypothetical protein Sfri_3844 7 None None None 114561496 Common - MscS Mechanosensitive ion channel Sfri_0308 215 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 114561795 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sfri_0610 60 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 114563239 Common - aminoglycoside phosphotransferase Sfri_2068 61 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 114562057 Common - cobyric acid synthase Sfri_0879 150 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 114564420 Common - protein of unknown function DUF897 Sfri_3259 31 COG3329 COG3329, Predicted permease General function prediction only 114564112 Common - transcriptional regulator, LysR family protein Sfri_2948 187 COG0583 LysR, Transcriptional regulator Transcription 114563941 Common xni exonuclease IX Sfri_2776 216 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 114563952 Common - flagellar motor protein PomA Sfri_2787 85 COG1291 MotA, Flagellar motor component Cell motility and secretion 114564715 Common - transposase Sfri_3563 9 None None None 114565046 Common - tetraheme cytochrome c Sfri_3896 5 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 114564672 Nonpathogen - hypothetical protein Sfri_3519 1 None None None 114563111 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Sfri_1940 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 114563883 Common - periplasmic sensor signal transduction histidine kinase Sfri_2718 222 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 114561989 Common - major facilitator superfamily MFS_1 Sfri_0809 17 None None None 114561340 Common rpsS 30S ribosomal protein S19 Sfri_0152 246 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 114561631 Common - diaminopimelate decarboxylase Sfri_0444 217 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 114563087 Common - hypothetical protein Sfri_1916 3 None None None 114561799 Common - Twin-arginine translocation pathway signal Sfri_0614 167 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 114563762 Common clpP ATP-dependent Clp protease proteolytic subunit Sfri_2596 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 114561829 Common - hypothetical protein Sfri_0644 1 None None None 114562929 Common - arsenate reductase Sfri_1754 113 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 114562492 Common - transcriptional regulator, LacI family protein Sfri_1314 128 COG1609 PurR, Transcriptional regulators Transcription 114562369 Common - flagellar biosynthesis protein, FliO Sfri_1191 10 COG3190 FliO, Flagellar biogenesis protein Cell motility and secretion 114562547 Common - methionine gamma-lyase Sfri_1369 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 114563428 Common - isocitrate dehydrogenase, NADP-dependent Sfri_2257 65 COG2838 Icd, Monomeric isocitrate dehydrogenase Energy production and conversion 114564631 Common - hypothetical protein Sfri_3475 27 COG4260 COG4260, Putative virion core protein (lumpy skin disease virus) Function unknown 114562489 Common - SapC family protein Sfri_1311 25 None None None 114563037 Common - dihydrodipicolinate synthase Sfri_1864 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 114561600 Common - Endoribonuclease L-PSP Sfri_0413 145 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 114562778 Common asnB asparagine synthetase B Sfri_1602 161 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 114561929 Common - oxidoreductase alpha (molybdopterin) subunit Sfri_0747 173 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 114565162 Nonpathogen - hypothetical protein Sfri_4012 2 None None None 114563385 Common - acyl-CoA dehydrogenase domain protein Sfri_2214 144 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 114561366 Common - heme exporter protein CcmB Sfri_0178 95 COG2386 CcmB, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 114562413 Nonpathogen - hypothetical protein Sfri_1235 5 None None None 114562445 Common dapD 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase Sfri_1267 139 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 114564017 Common - glutathione peroxidase Sfri_2853 114 COG0386 BtuE, Glutathione peroxidase Posttranslational modification, protein turnover, chaperones 114561430 Common - bioH protein Sfri_0242 105 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114564647 Common - phage integrase family protein Sfri_3494 10 None None None 114562437 Common - hypothetical protein Sfri_1259 4 None None None 114561258 Nonpathogen - hypothetical protein Sfri_0070 1 None None None 114563314 Common - Glutathione S-transferase, C-terminal domain protein Sfri_2143 97 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 114563406 Common - nucleoside recognition domain protein Sfri_2235 39 COG2715 SpmA, Uncharacterized membrane protein, required for spore maturation in B.subtilis. General function prediction only 114563825 Common - ABC transporter ATPase component Sfri_2659 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 114561192 Common - DNA gyrase, B subunit Sfri_0004 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 114564271 Common - sterol desaturase family protein Sfri_3109 75 COG3000 ERG3, Sterol desaturase Lipid metabolism 114563580 Common - hypothetical protein Sfri_2410 3 None None None 114564825 Common - putative cation efflux protein Sfri_3673 13 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 114565080 Common - cytidyltransferase-related domain Sfri_3930 145 COG0615 TagD, Cytidylyltransferase Cell envelope biogenesis, outer membrane / Lipid metabolism 114561513 Common glnA glutamine synthetase Sfri_0325 227 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 114562748 Common - periplasmic sensor signal transduction histidine kinase Sfri_1572 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114563352 Common - Holliday junction DNA helicase RuvA Sfri_2181 212 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 114564937 Common - Prepilin peptidase Sfri_3785 149 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 114562259 Common - OsmC family protein Sfri_1081 44 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 114564465 Common sspA stringent starvation protein A Sfri_3304 106 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 114562914 Common - membrane-bound lytic murein transglycosylase Sfri_1739 92 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 114563695 Common - putative sulfite oxidase subunit YedY Sfri_2527 125 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 114563769 Common - hypothetical protein Sfri_2603 15 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 114561331 Common rpsL 30S ribosomal protein S12 Sfri_0143 237 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 114562754 Nonpathogen - hypothetical protein Sfri_1578 16 None None None 114561854 Common - ATPase AAA-2 domain protein Sfri_0669 216 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 114562557 Common - glycosyl transferase, family 2 Sfri_1379 143 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 114561276 Common - ABC transporter related Sfri_0088 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 114562002 Common - hypothetical protein Sfri_0822 3 None None None 114563441 Common - TonB family protein Sfri_2270 16 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 114561655 Common - TatD-related deoxyribonuclease Sfri_0468 235 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 114563450 Common - hypothetical protein Sfri_2279 7 None None None 114563217 Common - Enoyl-CoA hydratase/isomerase Sfri_2046 153 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 114563620 Common - peptidase M23B Sfri_2450 187 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 114562335 Common - anti-sigma-28 factor, FlgM Sfri_1157 7 COG2747 FlgM, Negative regulator of flagellin synthesis (anti-sigma28 factor) Transcription / Cell motility and secretion / Intracellular trafficking and secretion 114563627 Common - RNA-binding S4 domain protein Sfri_2457 3 COG2501 COG2501, Uncharacterized conserved protein Function unknown 114562251 Common - hypothetical protein Sfri_1073 1 None None None 114562272 Common smpB SsrA-binding protein Sfri_1094 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 114562674 Common - malonyl CoA-acyl carrier protein transacylase Sfri_1498 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 114562220 Common - hypothetical protein Sfri_1042 1 None None None 114564525 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase Sfri_3364 221 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 114563621 Common - SMC domain protein Sfri_2451 88 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 114564547 Common - hypothetical protein Sfri_3386 27 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 114564165 Common - methyl-accepting chemotaxis sensory transducer Sfri_3002 148 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114561736 Common - elongation factor G Sfri_0550 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 114564638 Common - phage integrase family protein Sfri_3483 168 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 114561691 Common - periplasmic sensor signal transduction histidine kinase Sfri_0505 192 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 114561745 Common - hypothetical protein Sfri_0559 40 COG3647 COG3647, Predicted membrane protein Function unknown 114564795 Common - transcriptional regulator, MarR family protein Sfri_3643 97 COG1846 MarR, Transcriptional regulators Transcription 114564256 Common - Lysine exporter protein (LYSE/YGGA) Sfri_3094 129 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 114564171 Common - spermidine/putrescine ABC transporter ATPase subunit Sfri_3008 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 114562940 Common - succinyl-diaminopimelate desuccinylase Sfri_1765 205 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 114562820 Common - hypothetical protein Sfri_1644 1 None None None 114562854 Common - peptidase S14, ClpP Sfri_1678 165 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 114563052 Common - hypothetical protein Sfri_1880 15 None None None 114563663 Common - sulfatase Sfri_2493 35 COG3083 COG3083, Predicted hydrolase of alkaline phosphatase superfamily General function prediction only 114563617 Common - protein of unknown function DUF45 Sfri_2447 42 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 114562227 Common - (p)ppGpp synthetase I, SpoT/RelA Sfri_1049 205 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 114561890 Nonpathogen - hypothetical protein Sfri_0707 2 None None None 114562884 Common pheT phenylalanyl-tRNA synthetase subunit beta Sfri_1709 246 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 114564369 Common - Na(+)-translocating NADH-quinone reductase subunit D Sfri_3208 76 COG1347 NqrD, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD Energy production and conversion 114563024 Common - hypothetical protein Sfri_1851 16 None None None 114562518 Common - Butyryl-CoA dehydrogenase Sfri_1340 165 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 114563918 Common - prolyl-tRNA synthetase Sfri_2753 247 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 114564862 Common - single-strand binding protein Sfri_3710 213 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 114562112 Common - hypothetical protein Sfri_0934 1 None None None 114563706 Nonpathogen - hypothetical protein Sfri_2539 1 None None None 114561860 Common - ISSod10, transposase OrfA Sfri_0675 26 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 114561747 Common - uncharacterized domain 1 Sfri_0561 93 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 114565172 Common - peptidase M23B Sfri_4022 188 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 114564136 Common - peptidase M23B Sfri_2972 187 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 114562967 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Sfri_1792 180 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114564522 Common - AFG1-family ATPase Sfri_3361 103 COG1485 COG1485, Predicted ATPase General function prediction only 114562762 Nonpathogen - hypothetical protein Sfri_1586 1 None None None 114564794 Common - peptidase domain protein Sfri_3642 5 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 114561244 Common - Twin-arginine translocation pathway signal Sfri_0056 1 None None None 114565016 Common - conserved hypothetical 3-methyladenine DNA glycosylase Sfri_3866 87 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 114565107 Common - Amidohydrolase 3 Sfri_3957 113 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 114565053 Common - transcriptional regulator, XRE family protein Sfri_3903 9 COG1396 HipB, Predicted transcriptional regulators Transcription 114561757 Common - hypothetical protein Sfri_0571 1 None None None 114562531 Common - protein of unknown function DUF1415 Sfri_1353 30 COG3310 COG3310, Uncharacterized protein conserved in bacteria Function unknown 114565186 Common - histidine kinase Sfri_4036 19 COG3897 COG3897, Predicted methyltransferase General function prediction only 114564749 Common - OsmC family protein Sfri_3597 94 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 114563471 Common - metal dependent phosphohydrolase Sfri_2300 122 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 114562625 Common - hypothetical protein Sfri_1448 4 None None None 114562122 Common - 2OG-Fe(II) oxygenase Sfri_0944 40 COG3145 AlkB, Alkylated DNA repair protein DNA replication, recombination, and repair 114564294 Common - lipase, class 3 Sfri_3132 11 None None None 114562601 Common trpA tryptophan synthase subunit alpha Sfri_1424 214 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 114564804 Common - hypothetical protein Sfri_3652 2 None None None 114561961 Common - NAD-dependent epimerase/dehydratase Sfri_0780 66 COG2910 COG2910, Putative NADH-flavin reductase General function prediction only 114564726 Nonpathogen - hypothetical protein Sfri_3574 2 None None None 114562752 Common - glutathione-dependent formaldehyde-activating, GFA Sfri_1576 54 COG3791 COG3791, Uncharacterized conserved protein Function unknown 114563571 Common - beta-hexosaminidase Sfri_2401 173 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 114564849 Common - hypothetical protein Sfri_3697 28 COG4446 COG4446, Uncharacterized protein conserved in bacteria Function unknown 114565111 Common - transposase IS3/IS911 family protein Sfri_3961 60 None None None 114565099 Common - phospholipid/glycerol acyltransferase Sfri_3949 40 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 114561462 Common - putative methyltransferase Sfri_0274 209 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 114561324 Common - NusG antitermination factor Sfri_0136 215 COG0250 NusG, Transcription antiterminator Transcription 114564450 Common - hypothetical protein Sfri_3289 1 None None None 114561996 Common - aldo/keto reductase Sfri_0816 189 COG4989 COG4989, Predicted oxidoreductase General function prediction only 114561542 Common - hypothetical protein Sfri_0354 37 None None None 114564145 Common - Citrate transporter Sfri_2981 36 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 114563635 Common - hypothetical protein Sfri_2465 7 None None None 114562894 Common - Histidinol dehydrogenase Sfri_1719 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 114562715 Common - Thioredoxin domain-containing protein Sfri_1539 126 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 114564487 Common - glucose sorbosone dehydrogenase Sfri_3326 76 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 114561456 Common - hypothetical protein Sfri_0268 16 None None None 114563263 Common - aminotransferase, class V Sfri_2092 239 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 114563495 Common - protein of unknown function DUF124 Sfri_2324 73 COG2013 COG2013, Uncharacterized conserved protein Function unknown 114562178 Common - nucleoside transporter Sfri_1000 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 114562129 Common - Na(+)-translocating NADH-quinone reductase subunit C Sfri_0951 46 COG2869 NqrC, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC Energy production and conversion 114563011 Common - putative phenylacetate-coenzyme A ligase Sfri_1837 106 COG1541 PaaK, Coenzyme F390 synthetase Coenzyme metabolism 114561669 Common - uroporphyrinogen decarboxylase Sfri_0482 182 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 114562377 Common fliA flagellar biosynthesis sigma factor Sfri_1199 216 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 114562181 Common deoA thymidine phosphorylase Sfri_1003 118 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 114562133 Common - ApbE family lipoprotein Sfri_0955 138 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 114562991 Common - hypothetical protein Sfri_1816 24 None None None 114564195 Common - protein of unknown function DUF1365 Sfri_3032 63 COG3496 COG3496, Uncharacterized conserved protein Function unknown 114563595 Common - transcriptional regulator, BadM/Rrf2 family protein Sfri_2425 169 COG1959 COG1959, Predicted transcriptional regulator Transcription 114564894 Common - methylation site containing protein Sfri_3742 10 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 114562370 Common fliP flagellar biosynthesis protein FliP Sfri_1192 128 COG1338 FliP, Flagellar biosynthesis pathway, component FliP Cell motility and secretion / Intracellular trafficking and secretion 114561341 Common rplV 50S ribosomal protein L22 Sfri_0153 218 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 114564100 Common - L-aspartate oxidase Sfri_2936 226 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 114562998 Common - metal dependent phosphohydrolase Sfri_1823 121 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 114563042 Common - glutamine amidotransferase, class-II Sfri_1870 65 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 114562394 Common - fumarylacetoacetate (FAA) hydrolase Sfri_1216 175 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 114563521 Common - hypothetical protein Sfri_2350 18 None None None 114562515 Common - diguanylate cyclase Sfri_1337 177 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 114563877 Common - transcriptional regulator, AraC family protein Sfri_2712 117 COG2169 Ada, Adenosine deaminase Nucleotide transport and metabolism 114561551 Common - bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase Sfri_0363 207 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 114562797 Common - cystathionine beta-lyase Sfri_1621 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 114562068 Common - sulfotransferase Sfri_0890 44 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 114563232 Common - hypothetical protein Sfri_2061 14 COG4293 COG4293, Uncharacterized protein conserved in bacteria Function unknown 114563988 Common - undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase Sfri_2824 147 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 114564586 Common - Alcohol dehydrogenase GroES domain protein Sfri_3427 199 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 114563231 Common - Alcohol dehydrogenase, zinc-binding domain protein Sfri_2060 130 COG2130 COG2130, Putative NADP-dependent oxidoreductases General function prediction only 114564534 Common - 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase Sfri_3373 103 COG1778 COG1778, Low specificity phosphatase (HAD superfamily) General function prediction only 114562817 Nonpathogen - hypothetical protein Sfri_1641 1 None None None 114565207 Common - flavodoxin Sfri_4057 76 COG0716 FldA, Flavodoxins Energy production and conversion 114561620 Common - type I secretion outer membrane protein, TolC family protein Sfri_0433 128 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 114561774 Common - WD-40 repeat protein Sfri_0588 28 COG2319 COG2319, FOG: WD40 repeat General function prediction only 114562469 Common - RimK domain protein ATP-grasp Sfri_1291 70 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 114564246 Common - Dihydrofolate reductase Sfri_3084 146 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 114563933 Common - two component transcriptional regulator, winged helix family protein Sfri_2768 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114562119 Common - membrane-flanked domain Sfri_0941 19 COG3402 COG3402, Uncharacterized conserved protein Function unknown 114562082 Common - hypothetical protein Sfri_0904 62 COG3220 COG3220, Uncharacterized protein conserved in bacteria Function unknown 114564854 Common - Mammalian cell entry related domain protein Sfri_3702 111 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 114563930 Common - peptidase M1, membrane alanine aminopeptidase Sfri_2765 164 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 114561807 Common nrfA cytochrome c nitrite reductase Sfri_0622 40 COG3303 NrfA, Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit Inorganic ion transport and metabolism 114564626 Common - transposase Tn3 family protein Sfri_3470 52 COG4644 COG4644, Transposase and inactivated derivatives, TnpA family DNA replication, recombination, and repair 114561660 Common - 2-polyprenylphenol 6-hydroxylase Sfri_0473 184 COG0661 AarF, Predicted unusual protein kinase General function prediction only 114565194 Common - ATP synthase F1, epsilon subunit Sfri_4044 157 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 114563484 Common - lytic murein transglycosylase Sfri_2313 105 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 114561509 Common - signal transduction histidine kinase, nitrogen specific, NtrB Sfri_0321 217 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 114563076 Common - deoxyguanosinetriphosphate triphosphohydrolase-like protein Sfri_1905 160 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 114564737 Common - transcriptional repressor, CopY family protein Sfri_3585 30 COG3682 COG3682, Predicted transcriptional regulator Transcription 114561875 Common - lipoyl synthase Sfri_0692 190 COG0320 LipA, Lipoate synthase Coenzyme metabolism 114564262 Common - hypothetical protein Sfri_3100 6 None None None 114561966 Common - hypothetical protein Sfri_0786 9 COG3110 COG3110, Uncharacterized protein conserved in bacteria Function unknown 114563284 Common - hydrogenase expression/synthesis, HypA Sfri_2113 68 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 114563533 Common - protein of unknown function DUF1305 Sfri_2363 45 COG3520 COG3520, Uncharacterized protein conserved in bacteria Function unknown 114562298 Common engA GTP-binding protein EngA Sfri_1120 234 COG1160 COG1160, Predicted GTPases General function prediction only 114562194 Common - ferredoxin, 4Fe-4S Sfri_1016 76 None None None 114562202 Common - diguanylate cyclase/phosphodiesterase Sfri_1024 162 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114562611 Common - transcriptional regulator, LysR family protein Sfri_1434 165 COG0583 LysR, Transcriptional regulator Transcription 114562288 Common - NrfJ-related protein Sfri_1110 9 None None None 114563246 Common - hydratase/decarboxylase family protein Sfri_2075 12 COG3971 COG3971, 2-keto-4-pentenoate hydratase Secondary metabolites biosynthesis, transport, and catabolism 114561696 Common - secreted porin family protein Sfri_0510 27 None None None 114564705 Common - protein of unknown function DUF81 Sfri_3553 20 None None None 114564653 Common - serine/threonine protein kinase Sfri_3500 89 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 114562873 Common - hypothetical protein Sfri_1697 44 COG2996 COG2996, Uncharacterized protein conserved in bacteria Function unknown 114563939 Common - diguanylate cyclase Sfri_2774 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 114561772 Common - ferric uptake regulator, Fur family protein Sfri_0586 184 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 114564383 Common - PepSY-associated TM helix domain protein Sfri_3222 42 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 114563436 Common - Glu/Leu/Phe/Val dehydrogenase, dimerisation region Sfri_2265 168 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 114561939 Common - sodium:dicarboxylate symporter Sfri_0757 164 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 114562840 Nonpathogen - hypothetical protein Sfri_1664 1 None None None 114562956 Common - UspA domain protein Sfri_1781 48 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 114563040 Common - uncharacterized domain 1 Sfri_1868 42 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 114561612 Common - threonine dehydratase Sfri_0425 221 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 114561787 Common - transcriptional regulator, LuxR family protein Sfri_0602 125 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 114564215 Nonpathogen - hypothetical protein Sfri_3052 6 None None None 114563801 Common - hypothetical protein Sfri_2635 11 None None None 114562670 Common - hypothetical protein Sfri_1494 57 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 114564695 Common - Cupin 2, conserved barrel domain protein Sfri_3543 38 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 114562480 Common mdoG glucan biosynthesis protein G Sfri_1302 50 COG3131 MdoG, Periplasmic glucans biosynthesis protein Inorganic ion transport and metabolism 114563834 Common - N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase Sfri_2668 218 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 114563290 Common - orotidine 5'-phosphate decarboxylase Sfri_2119 160 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 114564632 Common - Resolvase, N-terminal domain protein Sfri_3477 134 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 114563949 Nonpathogen - hypothetical protein Sfri_2784 1 None None None 114561264 Common - coproporphyrinogen III oxidase Sfri_0076 203 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 114561970 Common - sulphate transporter Sfri_0790 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 114564243 Common apaH diadenosine tetraphosphatase Sfri_3081 85 COG0639 ApaH, Diadenosine tetraphosphatase and related serine/threonine protein phosphatases Signal transduction mechanisms 114563555 Common - Mn2+-dependent serine/threonine protein kinase Sfri_2385 14 COG3642 COG3642, Mn2+-dependent serine/threonine protein kinase Signal transduction mechanisms 114562153 Common - carbamoyl phosphate synthase small subunit Sfri_0975 234 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 114561506 Common - Transketolase, central region Sfri_0318 199 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 114564351 Common - hypothetical protein Sfri_3190 6 None None None 114562173 Common - polynucleotide phosphorylase/polyadenylase Sfri_0995 242 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 114563282 Common - hydrogenase expression/formation protein HypD Sfri_2111 109 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 114562118 Common - membrane-flanked domain Sfri_0940 26 COG3428 COG3428, Predicted membrane protein Function unknown 114563238 Common - short-chain dehydrogenase/reductase SDR Sfri_2067 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114564650 Nonpathogen - hypothetical protein Sfri_3497 2 None None None 114565201 Common - F0F1 ATP synthase subunit A Sfri_4051 207 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 114565193 Common - UDP-N-acetylglucosamine pyrophosphorylase Sfri_4043 234 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 114563010 Common - ABC transporter related Sfri_1836 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 114563940 Common - conserved hypothetical protein 730 Sfri_2775 40 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 114562200 Common - peptidase U32 Sfri_1022 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 114564583 Common - hypothetical protein Sfri_3423 3 None None None 114563596 Common - serine O-acetyltransferase Sfri_2426 196 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 114564846 Common - Twin-arginine translocation pathway signal Sfri_3694 46 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 114564418 Common - AFG1-family ATPase Sfri_3257 95 COG1485 COG1485, Predicted ATPase General function prediction only 114564454 Common - hypothetical protein Sfri_3293 1 COG3212 COG3212, Predicted membrane protein Function unknown 114563088 Common - catalase/peroxidase HPI Sfri_1917 98 COG0376 KatG, Catalase (peroxidase I) Inorganic ion transport and metabolism 114562353 Common - flagellar hook-associated 2 domain protein Sfri_1175 104 COG1345 FliD, Flagellar capping protein Cell motility and secretion 114562182 Common - phosphopentomutase Sfri_1004 70 COG1015 DeoB, Phosphopentomutase Carbohydrate transport and metabolism 114565036 Nonpathogen - hypothetical protein Sfri_3886 3 None None None 114563233 Common - AMP-dependent synthetase and ligase Sfri_2062 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 114562136 Common - bacterioferritin Sfri_0958 107 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 114563703 Common - exodeoxyribonuclease V, alpha subunit Sfri_2535 124 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 114564497 Common - Enoyl-CoA hydratase/isomerase Sfri_3336 152 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 114562254 Common - phosphoribosylaminoimidazole carboxylase, catalytic subunit Sfri_1076 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 114564947 Common - peptidase M23B Sfri_3797 188 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 114561741 Common - protein of unknown function DUF214 Sfri_0555 42 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 114563021 Nonpathogen - hypothetical protein Sfri_1848 4 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 114562777 Common - Integral membrane protein TerC Sfri_1601 118 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 114564869 Common - TonB-dependent siderophore receptor Sfri_3717 96 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 114561198 Common - hypothetical protein Sfri_0010 7 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 114562643 Common grxA glutaredoxin 1 Sfri_1466 43 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 114564125 Common - ABC transporter related Sfri_2961 249 COG4136 COG4136, ABC-type uncharacterized transport system, ATPase component General function prediction only 114561982 Common - diguanylate cyclase Sfri_0802 181 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 114562280 Common - isocitrate lyase Sfri_1102 128 COG2224 AceA, Isocitrate lyase Energy production and conversion 114563474 Common - transcriptional antiterminator, Rof Sfri_2303 2 COG4568 Rof, Transcriptional antiterminator Transcription 114561803 Common - Mg2 transporter protein, CorA family protein Sfri_0618 84 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 114561257 Nonpathogen - hypothetical protein Sfri_0069 1 None None None 114564296 Nonpathogen - hypothetical protein Sfri_3134 1 None None None 114562953 Common - hypothetical protein Sfri_1778 22 COG1901 COG1901, Uncharacterized conserved protein Function unknown 114562435 Common - oxidoreductase domain protein Sfri_1257 159 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 114563207 Common - uncharacterized conserved coiled coil protein Sfri_2036 20 None None None 114562718 Common nadE NAD synthetase Sfri_1542 174 COG0171 NadE, NAD synthase Coenzyme metabolism 114561541 Common - phospholipid/glycerol acyltransferase Sfri_0353 67 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 114563666 Common - HNH endonuclease Sfri_2497 21 COG3183 COG3183, Predicted restriction endonuclease Defense mechanisms 114562282 Common - hypothetical protein Sfri_1104 6 None None None 114565073 Common - hypothetical protein Sfri_3923 1 None None None 114561921 Common - uncharacterized domain Sfri_0738 52 COG1944 COG1944, Uncharacterized conserved protein Function unknown 114563259 Common - protein of unknown function DUF262 Sfri_2088 15 COG1479 COG1479, Uncharacterized conserved protein Function unknown 114561785 Nonpathogen - hypothetical protein Sfri_0600 1 None None None 114562408 Nonpathogen - hypothetical protein Sfri_1230 7 None None None 114564554 Common - Deoxycytidine deaminase-like protein Sfri_3393 59 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 114564478 Common - oligoribonuclease Sfri_3317 88 COG1949 Orn, Oligoribonuclease (3'->5' exoribonuclease) RNA processing and modification 114564903 Common - pilus (MSHA type) biogenesis protein MshL Sfri_3751 143 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 114565202 Common - ATP synthase I chain Sfri_4052 35 COG3312 AtpI, F0F1-type ATP synthase, subunit I Energy production and conversion 114561511 Common - protein of unknown function DUF1255 Sfri_0323 53 COG3123 COG3123, Uncharacterized protein conserved in bacteria Function unknown 114561891 Common - methylation site containing protein Sfri_0708 1 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 114564232 Common - Redoxin domain protein Sfri_3069 92 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 114563578 Common - adenine phosphoribosyltransferase Sfri_2408 187 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 114565089 Common tdh L-threonine 3-dehydrogenase Sfri_3939 210 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 114563373 Common - TonB-dependent receptor Sfri_2202 63 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 114561578 Common - Protein of unknown function UPF0011 Sfri_0390 209 COG0313 COG0313, Predicted methyltransferases General function prediction only 114565052 Common - periplasmic sensor signal transduction histidine kinase Sfri_3902 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114563295 Common - cytidylate kinase Sfri_2124 204 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 114564641 Common - mercuric reductase Sfri_3488 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 114561828 Common - GCN5-related N-acetyltransferase Sfri_0643 3 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 114562680 Common - cytochrome c3 Sfri_1504 1 None None None 114561843 Common - acriflavin resistance protein Sfri_0658 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 114562401 Nonpathogen - hypothetical protein Sfri_1223 7 None None None 114564192 Common - hypothetical protein Sfri_3029 25 None None None 114562731 Common - IstB domain protein ATP-binding protein Sfri_1555 105 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 114561454 Common - heavy metal efflux pump, CzcA family protein Sfri_0266 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 114564639 Nonpathogen - hypothetical protein Sfri_3485 1 None None None 114564792 Common - hypothetical protein Sfri_3640 5 None None None 114564873 Common - peptidase U62, modulator of DNA gyrase Sfri_3721 157 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 114561693 Common - hypothetical protein Sfri_0507 3 None None None 114562538 Common - transcriptional regulator PhoU Sfri_1360 191 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 114564130 Common - Adenosylhomocysteine nucleosidase Sfri_2966 101 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 114561469 Common - alpha/beta hydrolase fold Sfri_0281 123 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114563819 Common - PEP-utilizing enzyme Sfri_2653 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 114561812 Common - ABC-type amino acid transport/signal transduction systems Sfri_0627 9 None None None 114561477 Common - Sel1 domain protein repeat-containing protein Sfri_0289 48 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 114565149 Common - hypothetical protein Sfri_3999 7 None None None 114564745 Common - 3-dehydroquinate dehydratase Sfri_3593 169 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 114565185 Common - phosphate-selective porin O and P Sfri_4035 21 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 114563680 Common - transcriptional regulator, LysR family protein Sfri_2512 173 COG0583 LysR, Transcriptional regulator Transcription 114564501 Common - Integrase, catalytic region Sfri_3340 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 114564176 Common - transcriptional regulator, XRE family with cupin sensor Sfri_3013 43 COG1396 HipB, Predicted transcriptional regulators Transcription 114562742 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sfri_1566 10 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 114563511 Common - succinyl-CoA synthetase, alpha subunit Sfri_2340 213 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 114564016 Common - Ferrochelatase Sfri_2852 153 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 114563631 Common - DNA ligase, NAD-dependent Sfri_2461 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 114563154 Common - transcriptional regulator, LysR family protein Sfri_1983 106 COG0583 LysR, Transcriptional regulator Transcription 114563826 Common - glutaredoxin 2 Sfri_2660 17 None None None 114564536 Common - OstA family protein Sfri_3375 39 COG1934 COG1934, Uncharacterized protein conserved in bacteria Function unknown 114561836 Common - MATE efflux family protein Sfri_0651 184 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 114563853 Common - efflux transporter, RND family, MFP subunit Sfri_2688 64 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 114561872 Common - YheO domain protein Sfri_0689 48 COG2964 COG2964, Uncharacterized protein conserved in bacteria Function unknown 114563905 Common - NADH-ubiquinone oxidoreductase, chain 4L Sfri_2740 36 COG1006 MnhC, Multisubunit Na+/H+ antiporter, MnhC subunit Inorganic ion transport and metabolism 114564927 Common - dihydrolipoamide dehydrogenase Sfri_3775 244 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 114564938 Common - dephospho-CoA kinase Sfri_3786 207 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 114565007 Common - protein of unknown function DUF548 Sfri_3857 50 None None None 114563809 Common - Pyridoxal-dependent decarboxylase Sfri_2643 123 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 114561721 Common - aspartate kinase III Sfri_0535 232 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 114561634 Common - tyrosine recombinase XerC Sfri_0447 228 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 114561700 Common - DNA-binding transcriptional regulator AsnC Sfri_0514 156 COG1522 Lrp, Transcriptional regulators Transcription 114562619 Common - ribosomal protein L25 Sfri_1442 146 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 114561915 Common - nucleotide-binding protein Sfri_0732 107 COG1666 COG1666, Uncharacterized protein conserved in bacteria Function unknown 114562005 Common - putative signal transduction protein Sfri_0825 1 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 114561932 Common - heat shock protein DnaJ domain protein Sfri_0750 219 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 114564756 Common - peptidyl-prolyl cis-trans isomerase, cyclophilin type Sfri_3604 196 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 114562657 Common - hypothetical protein Sfri_1480 4 None None None 114563271 Common - MscS Mechanosensitive ion channel Sfri_2100 10 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 114563844 Common - protein of unknown function DUF58 Sfri_2679 105 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 114564358 Common - hypothetical protein Sfri_3197 8 None None None 114563586 Common - TonB-dependent receptor Sfri_2416 111 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 114563114 Common - transcriptional regulator, MarR family protein Sfri_1943 115 COG1846 MarR, Transcriptional regulators Transcription 114564236 Common - Nucleotidyl transferase Sfri_3074 224 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 114562263 Common - diguanylate cyclase Sfri_1085 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114561465 Common - protein of unknown function DUF214 Sfri_0277 110 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 114564543 Common - magnesium transporter Sfri_3382 171 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 114562451 Common - ribosome recycling factor Sfri_1273 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 114562751 Common - peptidase M23B Sfri_1575 161 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 114564529 Common - Mammalian cell entry related domain protein Sfri_3368 79 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 114561191 Common - DNA replication and repair protein RecF Sfri_0003 168 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 114564785 Common - cytochrome c, putative Sfri_3633 7 None None None 114562580 Common - hypothetical protein Sfri_1403 5 None None None 114561459 Nonpathogen - hypothetical protein Sfri_0271 8 None None None 114562022 Common - hypothetical protein Sfri_0844 20 COG3595 COG3595, Uncharacterized conserved protein Function unknown 114564896 Common - methylation site containing protein Sfri_3744 8 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 114561333 Common - elongation factor G Sfri_0145 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 114563252 Common - protein of unknown function UPF0153 Sfri_2081 9 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 114561437 Common - electron transport protein SCO1/SenC Sfri_0249 99 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 114562612 Common - efflux transporter, RND family, MFP subunit Sfri_1435 144 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 114563491 Common - hypothetical protein Sfri_2320 2 None None None 114561416 Common - regulatory protein RecX Sfri_0228 6 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 114562962 Common - TonB-dependent receptor Sfri_1787 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 114564778 Common - conserved hypothetical flavoprotein oxygenase Sfri_3626 83 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 114563316 Common - signal peptide peptidase SppA, 67K type Sfri_2145 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 114563135 Common - DNA-directed DNA polymerase Sfri_1964 175 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 114562345 Common flgH flagellar basal body L-ring protein Sfri_1167 101 COG2063 FlgH, Flagellar basal body L-ring protein Cell motility and secretion 114562496 Common - Beta-glucosidase Sfri_1318 113 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 114563423 Common - arginyl-tRNA-protein transferase Sfri_2252 85 COG2935 COG2935, Putative arginyl-tRNA:protein arginylyltransferase Posttranslational modification, protein turnover, chaperones 114563214 Common - hypothetical protein Sfri_2043 14 None None None 114561325 Common rplK 50S ribosomal protein L11 Sfri_0137 247 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 114562495 Common - glucose/galactose transporter Sfri_1317 51 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 114563833 Common - chorismate synthase Sfri_2667 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 114563158 Common - alpha/beta hydrolase fold Sfri_1987 50 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114564425 Common - spermidine synthase Sfri_3264 102 COG4262 COG4262, Predicted spermidine synthase with an N-terminal membrane domain General function prediction only 114562226 Common rumA 23S rRNA 5-methyluridine methyltransferase Sfri_1048 198 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 114564716 Common - hypothetical protein Sfri_3564 11 COG4729 COG4729, Uncharacterized conserved protein Function unknown 114561269 Common - Electron-transferring-flavoprotein dehydrogenase Sfri_0081 111 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 114562897 Common - putative transcriptional regulator, fis family protein Sfri_1722 9 None None None 114562911 Common - septum site-determining protein MinD Sfri_1736 142 COG2894 MinD, Septum formation inhibitor-activating ATPase Cell division and chromosome partitioning 114562849 Nonpathogen - hypothetical protein Sfri_1673 1 None None None 114562044 Common - Integrase, catalytic region Sfri_0866 143 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 114562946 Common - hypothetical protein Sfri_1771 10 None None None 114564273 Common - lipoprotein, putative Sfri_3111 10 COG3056 COG3056, Uncharacterized lipoprotein Cell envelope biogenesis, outer membrane 114561518 Common - hypothetical protein Sfri_0330 6 None None None 114564578 Nonpathogen - hypothetical protein Sfri_3417 2 None None None 114562453 Common - phosphatidate cytidylyltransferase Sfri_1275 215 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 114562925 Common - hypothetical protein Sfri_1750 19 COG3249 COG3249, Uncharacterized protein conserved in bacteria Function unknown 114561249 Nonpathogen - hypothetical protein Sfri_0061 1 None None None 114564932 Common - N-acetyl-anhydromuranmyl-L-alanine amidase Sfri_3780 110 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 114564436 Common - sugar fermentation stimulation protein Sfri_3275 107 COG1489 SfsA, DNA-binding protein, stimulates sugar fermentation General function prediction only 114563739 Common - competence protein ComEA helix-hairpin-helix repeat protein Sfri_2573 95 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 114563655 Common - phosphonate ABC transporter, periplasmic phosphonate-binding protein Sfri_2485 77 COG3221 PhnD, ABC-type phosphate/phosphonate transport system, periplasmic component Inorganic ion transport and metabolism 114563670 Common - hypothetical protein Sfri_2501 45 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 114561738 Common - cytochrome c-type protein NapB Sfri_0552 38 COG3043 NapB, Nitrate reductase cytochrome c-type subunit Energy production and conversion 114564945 Common - ISSod10, transposase OrfA Sfri_3795 26 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 114564457 Common - hypothetical protein Sfri_3296 23 None None None 114563191 Common - PP-loop domain protein Sfri_2020 157 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 114561494 Common - hypothetical protein Sfri_0306 7 None None None 114563909 Common - acyl-CoA dehydrogenase domain protein Sfri_2744 148 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 114563407 Common yebU rRNA (cytosine-C(5)-)-methyltransferase RsmF Sfri_2236 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 114561707 Common - conserved hypothetical spermidine synthase Sfri_0521 32 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 114564409 Common - hypothetical protein Sfri_3248 10 None None None 114564490 Common - Calcineurin phosphoesterase C-terminal domain protein Sfri_3329 81 COG1409 Icc, Predicted phosphohydrolases General function prediction only 114562871 Common - ABC-2 type transporter Sfri_1695 2 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 114564828 Common - two component transcriptional regulator, winged helix family protein Sfri_3676 220 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114563980 Common - transcriptional regulator, TetR family protein Sfri_2816 86 COG1309 AcrR, Transcriptional regulator Transcription 114563659 Common - metal dependent phosphohydrolase Sfri_2489 120 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 114562287 Common - GCN5-related N-acetyltransferase Sfri_1109 38 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 114562623 Common - putative signal transduction protein with CBS domains Sfri_1446 76 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 114563956 Common - GrpE protein Sfri_2791 230 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 114561557 Common - penicillin-binding protein, 1A family protein Sfri_0369 200 COG5009 MrcA, Membrane carboxypeptidase/penicillin-binding protein Cell envelope biogenesis, outer membrane 114564115 Common gltB glutamate synthase subunit alpha Sfri_2951 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 114563660 Common - magnesium and cobalt transport protein CorA Sfri_2490 152 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 114563399 Common - carboxy-terminal protease Sfri_2228 181 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 114561827 Common - hypothetical protein Sfri_0642 1 None None None 114564466 Common - cytochrome c1 Sfri_3305 70 COG2857 CYT1, Cytochrome c1 Energy production and conversion 114562468 Common - GCN5-related N-acetyltransferase Sfri_1290 82 COG0456 RimI, Acetyltransferases General function prediction only 114563891 Common - transcriptional regulator, MerR family protein Sfri_2726 54 COG0789 SoxR, Predicted transcriptional regulators Transcription 114563638 Common - cysteine synthase A Sfri_2468 219 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 114562697 Common - peptidase M61 domain protein Sfri_1521 57 COG3975 COG3975, Predicted protease with the C-terminal PDZ domain General function prediction only 114561754 Common - bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase Sfri_0568 220 COG4230 COG4230, Delta 1-pyrroline-5-carboxylate dehydrogenase Energy production and conversion 114564615 Common - hypothetical protein Sfri_3459 16 None None None 114564012 Common - mannosyl-3-phosphoglycerate phosphatase Sfri_2848 32 COG3769 COG3769, Predicted hydrolase (HAD superfamily) General function prediction only 114561233 Common - multiple antibiotic resistance (MarC)-related proteins Sfri_0045 155 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 114563073 Common - transposase, IS4 family protein Sfri_1902 17 None None None 114561571 Common - tryptophanyl-tRNA synthetase Sfri_0383 231 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 114562029 Common pbpG D-alanyl-D-alanine endopeptidase Sfri_0851 152 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 114563626 Common - protein of unknown function DUF1260 Sfri_2456 7 None None None 114562749 Common - two component transcriptional regulator, winged helix family protein Sfri_1573 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114561654 Common - diguanylate cyclase Sfri_0467 179 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 114561861 Common - porin, Gram-negative type Sfri_0677 16 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 114562535 Common - binding-protein-dependent transport systems inner membrane component Sfri_1357 221 COG4590 COG4590, ABC-type uncharacterized transport system, permease component General function prediction only 114564624 Common - PAP2 superfamily protein Sfri_3468 4 COG3907 COG3907, PAP2 (acid phosphatase) superfamily protein General function prediction only 114562816 Common - hypothetical protein Sfri_1640 1 None None None 114561573 Common - protein of unknown function DUF6, transmembrane Sfri_0385 79 COG2962 RarD, Predicted permeases General function prediction only 114562348 Common - flagellar hook-associated protein FlgK Sfri_1170 122 COG1256 FlgK, Flagellar hook-associated protein Cell motility and secretion 114563109 Common - quinolinate synthetase Sfri_1938 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 114564655 Common - multi-sensor hybrid histidine kinase Sfri_3502 226 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114561954 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Sfri_0773 93 COG0348 NapH, Polyferredoxin Energy production and conversion 114563335 Common - glycogen debranching enzyme GlgX Sfri_2164 157 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 114561952 Common - peptidase S45, penicillin amidase Sfri_0771 57 COG2366 COG2366, Protein related to penicillin acylase General function prediction only 114563339 Common - hypothetical protein Sfri_2168 2 None None None 114562888 Common - phosphoribosyl-AMP cyclohydrolase Sfri_1713 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 114562993 Common - binding-protein-dependent transport systems inner membrane component Sfri_1818 199 COG4176 ProW, ABC-type proline/glycine betaine transport system, permease component Amino acid transport and metabolism 114563954 Common - Polyprenyl synthetase Sfri_2789 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 114562318 Common - Lytic transglycosylase, catalytic Sfri_1140 111 COG4623 COG4623, Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein Cell envelope biogenesis, outer membrane 114564818 Common dipZ thiol:disulfide interchange protein precursor Sfri_3666 188 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 114561307 Common - tRNA 2-selenouridine synthase Sfri_0119 65 COG2603 COG2603, Predicted ATPase General function prediction only 114563126 Common - filamentation induced by cAMP protein Fic Sfri_1955 92 COG3177 COG3177, Uncharacterized conserved protein Function unknown 114564813 Common groES co-chaperonin GroES Sfri_3661 214 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 114562544 Common - alpha/beta hydrolase fold Sfri_1366 149 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114561975 Common - hypothetical protein Sfri_0795 129 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 114561667 Common - hypothetical protein Sfri_0480 19 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 114564852 Common - serine phosphatase Sfri_3700 108 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 114562321 Common - cytochrome d ubiquinol oxidase, subunit II Sfri_1143 156 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 114563673 Common - multi-sensor hybrid histidine kinase Sfri_2504 226 COG3300 COG3300, MHYT domain (predicted integral membrane sensor domain) Signal transduction mechanisms 114563134 Common - putative prophage repressor Sfri_1963 76 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 114564034 Common - glutaminase Sfri_2870 72 COG2066 GlsA, Glutaminase Amino acid transport and metabolism 114564329 Common - major facilitator superfamily MFS_1 Sfri_3168 28 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 114562513 Common - short chain dehydrogenase family protein Sfri_1335 33 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 114562066 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sfri_0888 53 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 114561231 Common - protein of unknown function DUF833 Sfri_0043 48 COG3332 COG3332, Uncharacterized conserved protein Function unknown 114563544 Common - OmpA/MotB domain protein Sfri_2374 128 COG3455 COG3455, Uncharacterized protein conserved in bacteria Function unknown 114563732 Common - protein of unknown function DUF214 Sfri_2566 85 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 114561671 Common - periplasmic sensor signal transduction histidine kinase Sfri_0484 212 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114564275 Common - hypothetical protein Sfri_3113 4 None None None 114562316 Common guaA bifunctional GMP synthase/glutamine amidotransferase protein Sfri_1138 238 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 114561368 Common - cytochrome c, class I Sfri_0180 46 COG3245 CycB, Cytochrome c5 Energy production and conversion 114564666 Common - hypothetical protein Sfri_3513 23 COG3076 COG3076, Uncharacterized protein conserved in bacteria Function unknown 114564513 Common - protein of unknown function DUF481 Sfri_3352 30 COG3137 COG3137, Putative salt-induced outer membrane protein Cell envelope biogenesis, outer membrane 114562363 Common fliI flagellum-specific ATP synthase Sfri_1185 247 COG1157 FliI, Flagellar biosynthesis/type III secretory pathway ATPase Cell motility and secretion / Intracellular trafficking and secretion 114564738 Common - heavy metal efflux pump, CzcA family protein Sfri_3586 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 114561987 Common - hypothetical protein Sfri_0807 4 None None None 114563035 Common bcp thioredoxin-dependent thiol peroxidase Sfri_1862 204 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 114561564 Common - 3-dehydroquinate synthase Sfri_0376 205 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 114564322 Common - short chain dehydrogenase Sfri_3161 214 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114563122 Common - helix-turn-helix domain protein Sfri_1951 58 COG2856 COG2856, Predicted Zn peptidase Amino acid transport and metabolism 114562095 Common - DNA polymerase III chi subunit, HolC Sfri_0917 54 COG2927 HolC, DNA polymerase III, chi subunit DNA replication, recombination, and repair 114563504 Common - hypothetical protein Sfri_2333 18 None None None 114564976 Common rpmG 50S ribosomal protein L33 Sfri_3826 132 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 114562261 Common - DSBA oxidoreductase Sfri_1083 86 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 114563714 Common - hypothetical protein Sfri_2547 5 None None None 114564780 Common - diguanylate cyclase Sfri_3628 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114564557 Common ubiA 4-hydroxybenzoate octaprenyltransferase Sfri_3396 178 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 114563995 Common - hypothetical protein Sfri_2831 8 COG2604 COG2604, Uncharacterized protein conserved in bacteria Function unknown 114564082 Common trmD tRNA (guanine-N(1)-)-methyltransferase Sfri_2918 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 114563969 Common - OmpA/MotB domain protein Sfri_2804 142 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 114561868 Common - transposase IS3/IS911 family protein Sfri_0684 50 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 114563756 Common - transcription activator, effector binding Sfri_2590 43 COG3449 COG3449, DNA gyrase inhibitor DNA replication, recombination, and repair 114562689 Common - Curlin associated repeat protein Sfri_1513 11 None None None 114561286 Common - Excinuclease ABC, C subunit domain protein Sfri_0098 79 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 114565155 Common - response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Sfri_4005 221 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114564074 Common - cytochrome c, class II Sfri_2910 34 COG3909 COG3909, Cytochrome c556 Energy production and conversion 114562235 Common - stationary-phase survival protein SurE Sfri_1057 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 114562331 Common - hypothetical protein Sfri_1153 11 None None None 114562230 Common eno phosphopyruvate hydratase Sfri_1052 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 114561342 Common rpsC 30S ribosomal protein S3 Sfri_0154 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 114562756 Common - Endonuclease/exonuclease/phosphatase Sfri_1580 32 COG3021 COG3021, Uncharacterized protein conserved in bacteria Function unknown 114562881 Common - protein of unknown function DUF785 Sfri_1706 26 COG4067 COG4067, Uncharacterized protein conserved in archaea Posttranslational modification, protein turnover, chaperones 114561810 Common - hypothetical protein Sfri_0625 1 None None None 114563846 Common - von Willebrand factor, type A Sfri_2681 73 COG2304 COG2304, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 114563884 Common - two component, sigma54 specific, transcriptional regulator, Fis family protein Sfri_2719 180 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 114564258 Common - TonB-dependent receptor Sfri_3096 79 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 114564568 Common - ribokinase Sfri_3407 175 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 114561699 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Sfri_0513 77 None None None 114562216 Common - Riboflavin synthase Sfri_1038 230 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 114563928 Common - MgtE intracellular region Sfri_2763 158 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 114561780 Common - OmpA/MotB domain protein Sfri_0594 155 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 114562705 Common - hypothetical protein Sfri_1529 3 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 114564060 Common - hypothetical protein Sfri_2896 86 COG3022 COG3022, Uncharacterized protein conserved in bacteria Function unknown 114562304 Common - hypothetical protein Sfri_1126 14 None None None 114563091 Common - D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase Sfri_1920 92 COG2027 DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) Cell envelope biogenesis, outer membrane 114563464 Nonpathogen - protein of unknown function DUF211 Sfri_2293 21 COG1888 COG1888, Uncharacterized protein conserved in archaea Function unknown 114564475 Common - N-acetylmuramoyl-L-alanine amidase Sfri_3314 178 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 114561204 Common - potassium uptake protein, TrkH family protein Sfri_0016 134 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 114564140 Common - iron-sulfur cluster assembly accessory protein Sfri_2976 166 COG0316 IscA, Uncharacterized conserved protein Function unknown 114562014 Common - membrane-flanked domain Sfri_0836 7 COG3428 COG3428, Predicted membrane protein Function unknown 114565086 Common - Three-deoxy-D-manno-octulosonic-acid transferase domain protein Sfri_3936 128 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 114562416 Common - hypothetical protein Sfri_1238 5 None None None 114565067 Common - putative sulfate transport system substrate-binding protein Sfri_3917 62 COG2998 TupB, ABC-type tungstate transport system, permease component Coenzyme metabolism 114564993 Common - filamentation induced by cAMP protein Fic Sfri_3843 102 COG3177 COG3177, Uncharacterized conserved protein Function unknown 114562051 Common - Phosphoglycerate mutase Sfri_0873 98 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 114564968 Common - isopropylmalate isomerase large subunit Sfri_3818 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 114563565 Common - lipoprotein releasing system, transmembrane protein, LolC/E family protein Sfri_2395 198 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 114562096 Nonpathogen - hypothetical protein Sfri_0918 2 None None None 114561690 Common - UBA/THIF-type NAD/FAD binding protein Sfri_0504 139 COG1179 COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Coenzyme metabolism 114563682 Common - RNA polymerase sigma factor SigZ Sfri_2514 91 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 114565152 Common - glyceraldehyde-3-phosphate dehydrogenase Sfri_4002 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 114563053 Common - hypothetical protein Sfri_1882 2 None None None 114563118 Common - betaine aldehyde dehydrogenase Sfri_1947 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 114564104 Common - hypothetical protein Sfri_2940 2 None None None 114562982 Common - ABC-1 domain protein Sfri_1807 185 COG0661 AarF, Predicted unusual protein kinase General function prediction only 114563689 Common - hypothetical protein Sfri_2521 34 None None None 114562501 Common - hypothetical protein Sfri_1323 8 None None None 114561217 Common - SUA5/yciO/yrdC, N-terminal domain protein Sfri_0029 240 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 114565170 Common - Rhodanese domain protein Sfri_4020 157 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 114561714 Common - hypothetical protein Sfri_0528 2 None None None 114562829 Common - hypothetical protein Sfri_1653 17 COG4189 COG4189, Predicted transcriptional regulator Transcription 114563241 Common - NADH:flavin oxidoreductase/NADH oxidase Sfri_2070 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 114564094 Common - signal peptidase I Sfri_2930 210 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 114563869 Common - protein of unknown function DUF479 Sfri_2704 33 COG3124 COG3124, Uncharacterized protein conserved in bacteria Function unknown 114562788 Common - Alcohol dehydrogenase GroES domain protein Sfri_1612 62 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 114562396 Common - 2-nitropropane dioxygenase, NPD Sfri_1218 21 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 114564336 Common - ribonuclease H Sfri_3175 169 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 114562426 Common queF 7-cyano-7-deazaguanine reductase Sfri_1248 73 COG2904 COG2904, Uncharacterized protein conserved in bacteria Function unknown 114563501 Common - gamma-glutamyltransferase Sfri_2330 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 114563719 Common - Nitrate reductase cytochrome c-type subunit (NapB) Sfri_2552 38 COG3043 NapB, Nitrate reductase cytochrome c-type subunit Energy production and conversion 114563962 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Sfri_2797 196 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114562338 Common - MCP methyltransferase, CheR-type Sfri_1160 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 114561900 Common - translation-associated GTPase Sfri_0717 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 114563573 Common - CreA family protein Sfri_2403 18 COG3045 CreA, Uncharacterized protein conserved in bacteria Function unknown 114561380 Common - acetylglutamate kinase Sfri_0192 211 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 114563730 Nonpathogen - hypothetical protein Sfri_2563 1 None None None 114564285 Nonpathogen - hypothetical protein Sfri_3123 2 None None None 114564776 Common - alpha/beta hydrolase fold Sfri_3624 92 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114564152 Common - undecaprenyl pyrophosphate phosphatase Sfri_2988 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 114561687 Common - GCN5-related N-acetyltransferase Sfri_0501 86 COG2153 ElaA, Predicted acyltransferase General function prediction only 114565094 Common - GTPase EngB Sfri_3944 176 COG0218 COG0218, Predicted GTPase General function prediction only 114563304 Common - ribonucleotide-diphosphate reductase subunit alpha Sfri_2133 210 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 114565038 Nonpathogen - hypothetical protein Sfri_3888 4 None None None 114562769 Common - lipoprotein, putative Sfri_1593 2 None None None 114563209 Common - protein of unknown function DUF885 Sfri_2038 37 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 114563353 Common - crossover junction endodeoxyribonuclease RuvC Sfri_2182 197 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 114563816 Common - protein of unknown function UPF0047 Sfri_2650 129 COG0432 COG0432, Uncharacterized conserved protein Function unknown 114563535 Common - protein of unknown function DUF1316 Sfri_2365 22 COG3518 COG3518, Uncharacterized protein conserved in bacteria Function unknown 114563228 Common - hypothetical protein Sfri_2057 58 COG3825 COG3825, Uncharacterized protein conserved in bacteria Function unknown 114563288 Common - hypothetical protein Sfri_2117 30 COG3122 COG3122, Uncharacterized protein conserved in bacteria Function unknown 114561850 Common - single-stranded-DNA-specific exonuclease RecJ Sfri_0665 192 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 114563773 Common - restriction modification system DNA specificity domain Sfri_2607 72 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 114561819 Common - hypothetical protein Sfri_0634 8 None None None 114564242 Common apaG ApaG Sfri_3080 89 COG2967 ApaG, Uncharacterized protein affecting Mg2+/Co2+ transport Inorganic ion transport and metabolism 114563049 Common - radical activating enzyme Sfri_1877 168 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 114562631 Common - Na+/H+ antiporter NhaC Sfri_1454 29 COG2056 COG2056, Predicted permease General function prediction only 114561606 Common - protein of unknown function DUF21 Sfri_0419 218 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 114562244 Common - pyruvate carboxylase subunit B Sfri_1066 197 COG5016 COG5016, Pyruvate/oxaloacetate carboxyltransferase Energy production and conversion 114562665 Common - bifunctional methionine sulfoxide reductase B/A protein Sfri_1488 206 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 114564807 Common - hypothetical protein Sfri_3655 56 COG2862 COG2862, Predicted membrane protein Function unknown 114563097 Common - ecotin precursor Sfri_1926 22 COG4574 Eco, Serine protease inhibitor ecotin General function prediction only 114563507 Common - hypothetical protein Sfri_2336 4 None None None 114561400 Common - copper-translocating P-type ATPase Sfri_0212 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 114563292 Common - protein of unknown function DUF1049 Sfri_2121 21 COG3771 COG3771, Predicted membrane protein Function unknown 114563971 Common - VacJ family lipoprotein Sfri_2807 94 COG2853 VacJ, Surface lipoprotein Cell envelope biogenesis, outer membrane 114562209 Common - hypothetical protein Sfri_1031 4 None None None 114565163 Common - Integrase, catalytic region Sfri_4013 143 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 114561643 Common - fumarate reductase cytochrome B subunit Sfri_0456 11 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 114564463 Common - glutamine amidotransferase of anthranilate synthase Sfri_3302 239 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 114561940 Common - diguanylate cyclase Sfri_0758 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114564069 Common - homoserine kinase Sfri_2905 114 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 114562725 Common - Exonuclease, RNase T and DNA polymerase III Sfri_1549 109 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 114563248 Common - ABC transporter related Sfri_2077 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 114564025 Common - pyrroline-5-carboxylate reductase Sfri_2861 211 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 114561619 Common - OmpA/MotB domain protein Sfri_0432 131 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 114564871 Common - methyl-accepting chemotaxis sensory transducer Sfri_3719 142 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114565044 Common - hypothetical protein Sfri_3894 15 None None None 114564963 Common - hypothetical protein Sfri_3813 142 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 114564363 Nonpathogen - hypothetical protein Sfri_3202 1 None None None 114563787 Common - Tetratricopeptide domain protein Sfri_2621 26 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 114564593 Common - glutathione-dependent formaldehyde-activating enzyme Sfri_3436 17 COG3791 COG3791, Uncharacterized conserved protein Function unknown 114562764 Common - hypothetical protein Sfri_1588 20 COG3102 COG3102, Uncharacterized protein conserved in bacteria Function unknown 114562801 Common - Vault protein inter-alpha-trypsin domain protein Sfri_1625 42 COG2425 COG2425, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 114562733 Common - ISSod10, transposase OrfB Sfri_1557 39 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 114561385 Nonpathogen - hypothetical protein Sfri_0197 5 None None None 114562806 Common - sulphate transporter Sfri_1630 160 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 114562382 Common - hypothetical protein Sfri_1204 1 None None None 114564876 Nonpathogen - hypothetical protein Sfri_3724 1 None None None 114561274 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Sfri_0086 137 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 114563415 Common - uridine kinase Sfri_2244 108 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 114563836 Common - phosphohistidine phosphatase, SixA Sfri_2670 65 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 114562595 Common - diguanylate cyclase/phosphodiesterase Sfri_1418 169 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 114563723 Common - hypothetical protein Sfri_2556 132 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 114563269 Common - lactoylglutathione lyase Sfri_2098 127 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 114562908 Common - long-chain-fatty-acid--CoA ligase Sfri_1733 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 114561242 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Sfri_0054 65 COG1145 NapF, Ferredoxin Energy production and conversion 114565031 Common - adenylate cyclase Sfri_3881 48 COG2954 COG2954, Uncharacterized protein conserved in bacteria Function unknown 114564207 Common - protein of unknown function DUF1294 Sfri_3044 55 COG3326 COG3326, Predicted membrane protein Function unknown 114561768 Common - peptide chain release factor 2 Sfri_0582 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 114561594 Common - protein of unknown function UPF0061 Sfri_0407 110 COG0397 COG0397, Uncharacterized conserved protein Function unknown 114564182 Common - 3-mercaptopyruvate sulfurtransferase Sfri_3019 143 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 114561351 Common rplF 50S ribosomal protein L6 Sfri_0163 240 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 114561964 Common - C4-dicarboxylate transporter/malic acid transport protein Sfri_0784 41 COG1275 TehA, Tellurite resistance protein and related permeases Inorganic ion transport and metabolism 114563741 Common - protein of unknown function DUF463, YcjX family protein Sfri_2575 42 COG3106 COG3106, Predicted ATPase General function prediction only 114562695 Common - curli production assembly/transport component CsgF precursor Sfri_1519 13 None None None 114562971 Common - outer membrane lipoprotein carrier protein LolA Sfri_1796 67 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 114563858 Common - CBS domain containing protein Sfri_2693 16 None None None 114564084 Common rpsP 30S ribosomal protein S16 Sfri_2920 209 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 114562936 Common - DegT/DnrJ/EryC1/StrS aminotransferase Sfri_1761 193 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 114563528 Common - PAAR repeat-containing protein Sfri_2358 28 COG4104 COG4104, Uncharacterized conserved protein Function unknown 114563454 Common - monovalent cation/proton antiporter, MnhG/PhaG subunit Sfri_2283 14 COG1320 MnhG, Multisubunit Na+/H+ antiporter, MnhG subunit Inorganic ion transport and metabolism 114562077 Common - protein of unknown function DUF214 Sfri_0899 23 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 114562522 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase Sfri_1344 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114562277 Common - hypothetical protein Sfri_1099 1 None None None 114562389 Common - protein of unknown function DUF785 Sfri_1211 39 COG4067 COG4067, Uncharacterized protein conserved in archaea Posttranslational modification, protein turnover, chaperones 114564985 Common pyrE orotate phosphoribosyltransferase Sfri_3835 136 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 114563612 Common nrdG anaerobic ribonucleotide reductase-activating protein Sfri_2442 60 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 114562508 Common - transcriptional regulator, TyrR Sfri_1330 168 COG3283 TyrR, Transcriptional regulator of aromatic amino acids metabolism Transcription / Amino acid transport and metabolism 114561215 Common - protein of unknown function DUF494 Sfri_0027 38 COG2922 Smg, Uncharacterized protein conserved in bacteria Function unknown 114562736 Common - secretion protein HlyD family protein Sfri_1560 148 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 114563419 Common - protein of unknown function DUF34 Sfri_2248 99 COG0327 COG0327, Uncharacterized conserved protein Function unknown 114562167 Common nusA transcription elongation factor NusA Sfri_0989 217 COG0195 NusA, Transcription elongation factor Transcription 114564443 Common - hypothetical protein Sfri_3282 1 None None None 114563168 Common - two component transcriptional regulator, LuxR family protein Sfri_1997 191 COG4566 TtrR, Response regulator Signal transduction mechanisms 114563557 Common - tetraacyldisaccharide 4'-kinase Sfri_2387 130 COG1663 LpxK, Tetraacyldisaccharide-1-P 4'-kinase Cell envelope biogenesis, outer membrane 114562249 Common - peptidase M16 domain protein Sfri_1071 191 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 114564374 Common - cysteine/glutathione ABC transporter membrane/ATP-binding component Sfri_3213 248 COG4988 CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 114562850 Common - phage DNA packaging Nu1 Sfri_1674 5 COG4220 COG4220, Phage DNA packaging protein, Nu1 subunit of terminase DNA replication, recombination, and repair 114563298 Common - serine transporter, putative Sfri_2127 32 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 114563894 Common - Enoyl-CoA hydratase/isomerase Sfri_2729 178 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 114563522 Common - hypothetical protein Sfri_2352 3 None None None 114561376 Common - protein of unknown function DUF1439 Sfri_0188 19 None None None 114563185 Common - hypothetical protein Sfri_2014 23 COG3198 COG3198, Uncharacterized protein conserved in bacteria Function unknown 114563345 Common - electron transport complex protein RnfC Sfri_2174 88 COG4656 RnfC, Predicted NADH:ubiquinone oxidoreductase, subunit RnfC Energy production and conversion 114564831 Common - RND efflux system, outer membrane lipoprotein, NodT family protein Sfri_3679 128 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 114561881 Common - rod shape-determining protein RodA Sfri_0698 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 114562839 Nonpathogen - protein of unknown function DUF1311 Sfri_1663 2 COG3755 COG3755, Uncharacterized protein conserved in bacteria Function unknown 114563375 Common - DNA polymerase III, epsilon subunit Sfri_2204 187 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 114563641 Common - TonB-dependent receptor Sfri_2471 111 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 114562081 Common - hypothetical protein Sfri_0903 27 None None None 114561526 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase Sfri_0338 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114564728 Common - hypothetical protein Sfri_3576 10 COG3453 COG3453, Uncharacterized protein conserved in bacteria Function unknown 114564678 Common - hypothetical protein Sfri_3525 5 None None None 114563341 Common - excinuclease ABC subunit B Sfri_2170 229 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 114564608 Common - umuD protein Sfri_3452 4 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 114564263 Common - rRNA (guanine-N(2)-)-methyltransferase Sfri_3101 89 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 114561300 Common - General secretion pathway protein K Sfri_0112 38 COG3156 PulK, Type II secretory pathway, component PulK Intracellular trafficking and secretion 114561764 Common - transcriptional regulator, MarR family protein Sfri_0578 124 COG1846 MarR, Transcriptional regulators Transcription 114562379 Common - chemotaxis phosphatase, CheZ Sfri_1201 46 COG3143 CheZ, Chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114563222 Common - Integrase, catalytic region Sfri_2051 143 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 114561582 Common - protein of unknown function DUF1212 Sfri_0394 42 COG2966 COG2966, Uncharacterized conserved protein Function unknown 114561424 Common - sulfatase Sfri_0236 61 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 114564836 Common - anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family protein Sfri_3684 178 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 114561221 Common - amidohydrolase Sfri_0033 35 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 114564223 Common - hypothetical protein Sfri_3060 10 COG3904 COG3904, Predicted periplasmic protein Function unknown 114562145 Common proA gamma-glutamyl phosphate reductase Sfri_0967 188 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 114564918 Common - protein of unknown function DUF971 Sfri_3766 51 COG3536 COG3536, Uncharacterized protein conserved in bacteria Function unknown 114564159 Common - DNA primase Sfri_2995 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 114563196 Common rplT 50S ribosomal protein L20 Sfri_2025 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 114562340 Common flgC flagellar basal body rod protein FlgC Sfri_1162 126 COG1558 FlgC, Flagellar basal body rod protein Cell motility and secretion 114561947 Common - Alcohol dehydrogenase, zinc-binding domain protein Sfri_0766 165 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 114562704 Common - nicotinamide mononucleotide transporter PnuC Sfri_1528 55 COG3201 PnuC, Nicotinamide mononucleotide transporter Coenzyme metabolism 114562577 Common - hypothetical protein Sfri_1400 5 COG2384 COG2384, Predicted SAM-dependent methyltransferase General function prediction only 114564588 Common - glutathione synthetase Sfri_3429 34 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 114561322 Common - elongation factor Tu Sfri_0134 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 114562877 Common - pyridoxamine 5'-phosphate oxidase Sfri_1702 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 114564147 Common - Peptidoglycan-binding domain 1 protein Sfri_2983 64 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 114561833 Common - D-erythrose-4-phosphate dehydrogenase Sfri_0648 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 114562795 Nonpathogen - hypothetical protein Sfri_1619 1 None None None 114563378 Common - Hydroxyacylglutathione hydrolase Sfri_2207 187 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 114562433 Common - GCN5-related N-acetyltransferase Sfri_1255 7 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 114564298 Common - hypothetical protein Sfri_3136 6 None None None 114561255 Common - acetyltransferase, GNAT family protein Sfri_0067 5 COG3375 COG3375, Uncharacterized conserved protein Function unknown 114564711 Common - alpha/beta superfamily hydrolase Sfri_3559 14 None None None 114564160 Common - RNA polymerase, sigma 70 subunit, RpoD Sfri_2996 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 114562641 Common - hypothetical protein Sfri_1464 78 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 114562954 Nonpathogen - hypothetical protein Sfri_1779 6 None None None 114564020 Common - transposase IS3/IS911 family protein Sfri_2856 60 None None None 114564506 Common alr alanine racemase Sfri_3345 200 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 114564683 Common - response regulator receiver protein Sfri_3531 221 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 114564891 Common - hypothetical protein Sfri_3739 21 None None None 114564476 Common - protein of unknown function UPF0079 Sfri_3315 208 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 114562712 Common - diguanylate cyclase Sfri_1536 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 114561516 Common - transcriptional regulator, AsnC family protein Sfri_0328 156 COG1522 Lrp, Transcriptional regulators Transcription 114564106 Common thyA thymidylate synthase Sfri_2942 134 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 114562169 Common rbfA ribosome-binding factor A Sfri_0991 163 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 114561196 Common - DNA-3-methyladenine glycosylase I Sfri_0008 132 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 114562565 Common - O-antigen polymerase Sfri_1388 30 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 114562403 Nonpathogen - hypothetical protein Sfri_1225 6 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 114562951 Common - major facilitator superfamily MFS_1 Sfri_1776 40 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 114562472 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sfri_1294 136 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 114563672 Common - acyl-CoA synthetase Sfri_2503 225 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 114563085 Common - replication initiation regulator SeqA Sfri_1914 23 COG3057 SeqA, Negative regulator of replication initiationR DNA replication, recombination, and repair 114565059 Common - diguanylate cyclase/phosphodiesterase Sfri_3909 164 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 114563488 Common - peptidase S16, lon domain protein Sfri_2317 41 COG2802 COG2802, Uncharacterized protein, similar to the N-terminal domain of Lon protease General function prediction only 114564867 Common - protein of unknown function DUF6, transmembrane Sfri_3715 49 COG2962 RarD, Predicted permeases General function prediction only 114563260 Common - hypothetical protein Sfri_2089 10 None None None 114562934 Common - 3-deoxy-manno-octulosonate cytidylyltransferase Sfri_1759 154 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 114562196 Common - Ig domain protein, group 2 domain protein Sfri_1018 72 None None None 114561801 Common - hypothetical protein Sfri_0616 1 None None None 114564234 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Sfri_3072 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 114561695 Common - tetraheme cytochrome c Sfri_0509 3 None None None 114562610 Common - putative transcriptional regulator Sfri_1433 155 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 114562284 Common - transcriptional regulator, CopG family protein Sfri_1106 3 None None None 114563588 Common - alpha-L-glutamate ligases, RimK family protein Sfri_2418 147 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 114564798 Common - Carboxymuconolactone decarboxylase Sfri_3646 66 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 114564062 Common - putative phosphoketolase Sfri_2898 66 COG3957 COG3957, Phosphoketolase Carbohydrate transport and metabolism 114563027 Common - protein of unknown function DUF162 Sfri_1854 22 COG1556 COG1556, Uncharacterized conserved protein Function unknown 114563371 Common - thiamine-phosphate pyrophosphorylase Sfri_2200 219 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 114565212 Common trmE tRNA modification GTPase TrmE Sfri_4062 231 COG0486 ThdF, Predicted GTPase General function prediction only 114562191 Common - peptidase U32 Sfri_1013 50 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 114564773 Common - DSBA oxidoreductase Sfri_3621 45 COG3917 NahD, 2-hydroxychromene-2-carboxylate isomerase Secondary metabolites biosynthesis, transport, and catabolism 114562943 Common - phosphoenolpyruvate-protein phosphotransferase Sfri_1768 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 114563937 Common - peptidase M61 domain protein Sfri_2772 59 COG3975 COG3975, Predicted protease with the C-terminal PDZ domain General function prediction only 114562969 Common - leucine-responsive transcriptional regulator Sfri_1794 158 COG1522 Lrp, Transcriptional regulators Transcription 114561470 Common - 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase Sfri_0282 110 COG1165 MenD, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Coenzyme metabolism 114564089 Common - holo-acyl-carrier-protein synthase Sfri_2925 100 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 114562161 Common - ATP-dependent metalloprotease FtsH Sfri_0983 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 114562744 Common - heat shock protein HtpX Sfri_1568 189 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 114561479 Common - hypothetical protein Sfri_0291 2 None None None 114564132 Common - hypothetical protein Sfri_2968 20 None None None 114563619 Common - GCN5-related N-acetyltransferase Sfri_2449 10 None None None 114563687 Common - hypothetical protein Sfri_2519 1 None None None 114564190 Common - hypothetical protein Sfri_3027 1 None None None 114563443 Common - protein of unknown function DUF1538 Sfri_2272 23 None None None 114564875 Common - Ig domain protein, group 1 domain protein Sfri_3723 29 None None None 114561949 Nonpathogen - hypothetical protein Sfri_0768 9 None None None 114564174 Common - Glutamate--ammonia ligase Sfri_3011 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 114562114 Common - transcriptional regulator, TetR family protein Sfri_0936 99 COG1309 AcrR, Transcriptional regulator Transcription 114561404 Common - methyl-accepting chemotaxis sensory transducer Sfri_0216 75 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114564908 Common - regulatory protein CsrD Sfri_3756 158 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 114565072 Common - molybdenum cofactor biosynthesis protein A Sfri_3922 197 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 114561937 Common - Integrase, catalytic region Sfri_0755 143 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 114564323 Common folE GTP cyclohydrolase I Sfri_3162 176 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 114561870 Common - L-serine dehydratase 1 Sfri_0687 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 114562116 Common - UspA domain protein Sfri_0938 86 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 114561467 Common - O-succinylbenzoate-CoA ligase Sfri_0279 214 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 114562120 Common - hypothetical protein Sfri_0942 9 COG4519 COG4519, Uncharacterized protein conserved in bacteria Function unknown 114563537 Common - protein of unknown function DUF877 Sfri_2367 50 COG3517 COG3517, Uncharacterized protein conserved in bacteria Function unknown 114564413 Common - transcriptional regulator, MarR family protein Sfri_3252 84 COG1846 MarR, Transcriptional regulators Transcription 114564629 Common - cation diffusion facilitator family transporter Sfri_3473 164 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 114565191 Common - transcriptional regulator, DeoR family protein Sfri_4041 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 114561972 Common - formate dehydrogenase, alpha subunit Sfri_0792 239 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 114561913 Common - 2-dehydropantoate 2-reductase Sfri_0730 81 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 114564898 Common - hypothetical protein Sfri_3746 1 None None None 114563235 Common - short-chain dehydrogenase/reductase SDR Sfri_2064 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114562719 Common - hypothetical protein Sfri_1543 4 None None None 114564929 Common aceE pyruvate dehydrogenase subunit E1 Sfri_3777 149 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 114563999 Common - HAD-superfamily phosphatase, subfamily IIIC Sfri_2835 29 COG3882 FkbH, Predicted enzyme involved in methoxymalonyl-ACP biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 114561852 Common - pseudouridine synthase, RluA family protein Sfri_0667 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 114564169 Common - binding-protein-dependent transport systems inner membrane component Sfri_3006 190 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 114563945 Common - hypothetical protein Sfri_2780 46 COG2933 COG2933, Predicted SAM-dependent methyltransferase General function prediction only 114565168 Common gpsA NAD(P)H-dependent glycerol-3-phosphate dehydrogenase Sfri_4018 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 114563942 Common - hypothetical protein Sfri_2777 4 None None None 114564920 Nonpathogen - hypothetical protein Sfri_3768 1 None None None 114564532 Common - Na+/Ca+ antiporter, CaCA family protein Sfri_3371 114 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 114563879 Common - glutamyl-tRNA synthetase Sfri_2714 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 114562291 Common - hypothetical protein Sfri_1113 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 114562042 Common - transposase IS116/IS110/IS902 family protein Sfri_0864 43 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 114564531 Common - ABC transporter related Sfri_3370 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 114564484 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Sfri_3323 218 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 114562883 Common pheS phenylalanyl-tRNA synthetase subunit alpha Sfri_1708 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 114564353 Common - sulfite reductase (NADPH) hemoprotein, beta-component Sfri_3192 149 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 114564423 Common - hypothetical protein Sfri_3262 4 None None None 114561770 Common - thioesterase superfamily protein Sfri_0584 13 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 114562343 Common flgF flagellar basal body rod protein FlgF Sfri_1165 121 COG4787 FlgF, Flagellar basal body rod protein Cell motility and secretion 114562024 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sfri_0846 159 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 114564799 Common - cold-shock DNA-binding domain protein Sfri_3647 23 COG1278 CspC, Cold shock proteins Transcription 114561262 Common - transcriptional regulator, AraC family protein Sfri_0074 107 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 114561347 Common rplX 50S ribosomal protein L24 Sfri_0159 208 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 114561610 Common ilvM acetolactate synthase 2 regulatory subunit Sfri_0423 22 COG3978 COG3978, Acetolactate synthase (isozyme II), small (regulatory) subunit Function unknown 114563438 Common - phospholipid/glycerol acyltransferase Sfri_2267 58 COG3176 COG3176, Putative hemolysin General function prediction only 114562293 Common - hypothetical protein Sfri_1115 60 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 114563425 Common - ATP-dependent Clp protease, ATP-binding subunit clpA Sfri_2254 217 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 114563200 Common - hypothetical protein Sfri_2029 17 None None None 114564217 Common - ATP synthase F0, C subunit Sfri_3054 78 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 114561942 Common - pyrroline-5-carboxylate reductase Sfri_0761 212 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 114562138 Nonpathogen - Ankyrin Sfri_0960 2 None None None 114561664 Common - ribonuclease activity regulator protein RraA Sfri_0477 94 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 114564001 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Sfri_2837 230 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 114562184 Common - membrane protein Sfri_1006 1 COG3726 AhpA, Uncharacterized membrane protein affecting hemolysin expression General function prediction only 114562256 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sfri_1078 148 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 114563008 Common - inner-membrane translocator Sfri_1834 161 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 114565028 Common - Integrase, catalytic region Sfri_3878 34 None None None 114564438 Common - Glutamate--tRNA ligase Sfri_3277 228 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 114561189 Common dnaA chromosomal replication initiation protein Sfri_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 114563951 Common motB flagellar motor protein MotB Sfri_2786 144 COG1360 MotB, Flagellar motor protein Cell motility and secretion 114562608 Common - Sua5/YciO/YrdC/YwlC family protein Sfri_1431 195 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 114563912 Common - electron transfer flavoprotein, alpha subunit Sfri_2747 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 114561448 Common - LexA repressor Sfri_0260 168 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 114563926 Common - dTDP-4-dehydrorhamnose reductase Sfri_2761 166 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 114564188 Common - hypothetical protein Sfri_3025 35 None None None 114564117 Common - type IV pilus assembly PilZ Sfri_2953 7 None None None 114564618 Common - heavy metal translocating P-type ATPase Sfri_3462 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 114561791 Common - hypothetical protein Sfri_0606 7 None None None 114561492 Common - peptidase M16 domain protein Sfri_0304 176 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 114564181 Common - hypothetical protein Sfri_3018 3 COG3904 COG3904, Predicted periplasmic protein Function unknown 114563657 Common - periplasmic sensor signal transduction histidine kinase Sfri_2487 207 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114565021 Nonpathogen - hypothetical protein Sfri_3871 1 None None None 114563005 Common - ABC transporter related Sfri_1831 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 114563409 Common - type IV pilus biogenesis protein pilZ Sfri_2238 33 COG3215 PilZ, Tfp pilus assembly protein PilZ Cell motility and secretion / Intracellular trafficking and secretion 114565112 Nonpathogen - hypothetical protein Sfri_3962 1 None None None 114562455 Common - putative membrane-associated zinc metalloprotease Sfri_1277 213 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 114563653 Common - binding-protein-dependent transport systems inner membrane component Sfri_2483 83 COG3639 COG3639, ABC-type phosphate/phosphonate transport system, permease component Inorganic ion transport and metabolism 114561576 Common - hypothetical protein Sfri_0388 137 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 114563991 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Sfri_2827 167 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 114564401 Common - SlyX family protein Sfri_3240 25 COG2900 SlyX, Uncharacterized protein conserved in bacteria Function unknown 114563886 Common - hypothetical protein Sfri_2721 3 COG3126 COG3126, Uncharacterized protein conserved in bacteria Function unknown 114562127 Common - Na(+)-translocating NADH-quinone reductase subunit A Sfri_0949 39 COG1726 NqrA, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA Energy production and conversion 114563558 Common - lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA Sfri_2388 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 114564037 Common - A/G-specific adenine glycosylase Sfri_2873 226 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 114561559 Common - Fimbrial assembly family protein Sfri_0371 47 COG3166 PilN, Tfp pilus assembly protein PilN Cell motility and secretion / Intracellular trafficking and secretion 114563071 Common - transcriptional regulator, DeoR family protein Sfri_1900 63 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 114564576 Common - IstB domain protein ATP-binding protein Sfri_3415 105 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 114563388 Common - Phosphoglycerate mutase Sfri_2217 23 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 114561825 Common - arginine repressor Sfri_0640 76 COG1438 ArgR, Arginine repressor Transcription 114563870 Common - Redoxin domain protein Sfri_2705 33 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 114564431 Common - penicillin-binding protein 1B Sfri_3270 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 114561709 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Sfri_0523 249 COG3634 AhpF, Alkyl hydroperoxide reductase, large subunit Posttranslational modification, protein turnover, chaperones 114562868 Common rrmA 23S rRNA methyltransferase A Sfri_1692 76 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 114563982 Common - TonB-dependent receptor, plug Sfri_2818 64 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 114561435 Common - MATE efflux family protein Sfri_0247 103 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 114563974 Nonpathogen - hypothetical protein Sfri_2810 1 None None None 114561544 Common - ATP-dependent DNA helicase RecG Sfri_0356 227 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 114563907 Common - NADH dehydrogenase (quinone) Sfri_2742 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 114562155 Common - transcription elongation factor GreA Sfri_0977 204 COG0782 GreA, Transcription elongation factor Transcription 114561235 Common - peptidase M6, immune inhibitor A Sfri_0047 59 COG4412 COG4412, Uncharacterized protein conserved in bacteria Function unknown 114562648 Common - Glutathione S-transferase, N-terminal domain protein Sfri_1471 101 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 114564238 Common - Organic solvent tolerance protein Sfri_3076 121 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 114564344 Common - Twin-arginine translocation pathway signal Sfri_3183 101 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 114561499 Common - two component transcriptional regulator, winged helix family protein Sfri_0311 219 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114562678 Common - thioesterase superfamily protein Sfri_1502 124 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 114563541 Common - protein serine/threonine phosphatase Sfri_2371 141 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 114562814 Common sbcB exonuclease I Sfri_1638 51 COG2925 SbcB, Exonuclease I DNA replication, recombination, and repair 114561652 Common - transposase Sfri_0465 9 None None None 114563397 Common - hypothetical protein Sfri_2226 6 None None None 114564010 Common - alpha amylase, catalytic region Sfri_2846 129 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 114561858 Common - ISSod10, transposase OrfA Sfri_0673 26 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 114562861 Nonpathogen - hypothetical protein Sfri_1685 1 None None None 114564622 Common - transposase Tn3 family protein Sfri_3466 52 COG4644 COG4644, Transposase and inactivated derivatives, TnpA family DNA replication, recombination, and repair 114562863 Common - hypothetical protein Sfri_1687 3 None None None 114563893 Common - Propionyl-CoA carboxylase Sfri_2728 143 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 114563701 Common - exodeoxyribonuclease V, gamma subunit Sfri_2533 66 COG1330 RecC, Exonuclease V gamma subunit DNA replication, recombination, and repair 114564150 Nonpathogen - hypothetical protein Sfri_2986 1 None None None 114565108 Common - hypothetical protein Sfri_3958 20 COG4453 COG4453, Uncharacterized protein conserved in bacteria Function unknown 114563795 Common - DNA polymerase II Sfri_2629 66 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 114562491 Common - TonB-dependent receptor, plug Sfri_1313 40 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 114562224 Common - protein of unknown function DUF416 Sfri_1046 26 COG3068 COG3068, Uncharacterized protein conserved in bacteria Function unknown 114564014 Common - protein of unknown function DUF179 Sfri_2850 129 COG1678 COG1678, Putative transcriptional regulator Transcription 114562918 Common - fatty acid metabolism regulator Sfri_1743 69 COG2186 FadR, Transcriptional regulators Transcription 114561311 Common - Stearoyl-CoA 9-desaturase Sfri_0123 66 COG1398 OLE1, Fatty-acid desaturase Lipid metabolism 114563600 Common - type IV pilus assembly PilZ Sfri_2430 1 None None None 114561628 Common cyaA adenylate cyclase Sfri_0441 25 COG3072 CyaA, Adenylate cyclase Nucleotide transport and metabolism 114562784 Common - hypothetical protein Sfri_1608 2 None None None 114561414 Common - transcriptional regulator, TetR family protein Sfri_0226 35 COG1309 AcrR, Transcriptional regulator Transcription 114564700 Common - protein of unknown function DUF1097 Sfri_3548 13 None None None 114564758 Common - GCN5-related N-acetyltransferase Sfri_3606 91 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 114564815 Common - hypothetical protein Sfri_3663 2 None None None 114563357 Common - putative methyltransferase Sfri_2186 48 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 114564056 Common - integral membrane protein MviN Sfri_2892 198 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 114564385 Common - hypothetical protein Sfri_3224 1 None None None 114565050 Common - protein of unknown function DUF347 Sfri_3900 27 COG4705 COG4705, Uncharacterized membrane-anchored protein conserved in bacteria Function unknown 114561718 Common - peptidase S9B, dipeptidylpeptidase IV domain protein Sfri_0532 109 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 114562398 Common - omega-3 polyunsaturated fatty acid synthase PfaB Sfri_1220 20 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 114563364 Common - transcriptional regulator, LysR family protein Sfri_2193 158 COG0583 LysR, Transcriptional regulator Transcription 114562899 Nonpathogen - hypothetical protein Sfri_1724 1 None None None 114563152 Common - beta-lactamase domain protein Sfri_1981 201 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 114564253 Common - uracil-DNA glycosylase Sfri_3091 128 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 114561930 Common - formate dehydrogenase family accessory protein FdhD Sfri_0748 129 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 114564999 Common - alpha/beta hydrolase fold Sfri_3849 26 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 114562790 Common - transcriptional regulator, LysR family protein Sfri_1614 178 COG0583 LysR, Transcriptional regulator Transcription 114564251 Common rplU 50S ribosomal protein L21 Sfri_3089 213 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 114563182 Common - cytochrome c oxidase, cbb3-type, subunit II Sfri_2011 82 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 114565140 Common - Sucrose phosphorylase Sfri_3990 98 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 114561834 Common pgk phosphoglycerate kinase Sfri_0649 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 114564787 Common - Prolyl oligopeptidase Sfri_3635 114 COG1505 COG1505, Serine proteases of the peptidase family S9A Amino acid transport and metabolism 114563203 Common - aldehyde dehydrogenase Sfri_2032 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 114561866 Common aspA aspartate ammonia-lyase Sfri_0682 234 COG1027 AspA, Aspartate ammonia-lyase Amino acid transport and metabolism 114561279 Common - periplasmic sensor signal transduction histidine kinase Sfri_0091 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114563548 Common - serine/threonine protein kinase Sfri_2378 149 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 114565174 Common - transcriptional regulator, BadM/Rrf2 family protein Sfri_4024 125 COG1959 COG1959, Predicted transcriptional regulator Transcription 114562617 Common - Peptidoglycan-binding domain 1 protein Sfri_1440 74 COG2989 COG2989, Uncharacterized protein conserved in bacteria Function unknown 114562498 Common - 3'(2'),5'-bisphosphate nucleotidase Sfri_1320 188 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 114562449 Common tsf elongation factor Ts Sfri_1271 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 114565079 Common - ADP-L-glycero-D-manno-heptose-6-epimerase Sfri_3929 225 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 114563807 Common - Gluconate transporter Sfri_2641 77 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 114564634 Common - Tn5044 transposase Sfri_3479 49 COG4644 COG4644, Transposase and inactivated derivatives, TnpA family DNA replication, recombination, and repair 114563017 Common - periplasmic sensor signal transduction histidine kinase Sfri_1843 57 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114564341 Common - aldo/keto reductase Sfri_3180 192 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 114564291 Common - outer membrane protein Sfri_3129 9 None None None 114563212 Common - nitroreductase Sfri_2041 49 COG0778 NfnB, Nitroreductase Energy production and conversion 114562913 Common - protein of unknown function DUF709 Sfri_1738 34 COG3100 COG3100, Uncharacterized protein conserved in bacteria Function unknown 114563258 Common - type III restriction enzyme, res subunit Sfri_2087 67 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 114562845 Nonpathogen - hypothetical protein Sfri_1669 1 None None None 114563156 Common - hypothetical protein Sfri_1985 14 None None None 114564949 Common lpxC UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase Sfri_3799 139 COG0774 LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase Cell envelope biogenesis, outer membrane 114562847 Common - glycoside hydrolase, family 24 Sfri_1671 42 COG3772 COG3772, Phage-related lysozyme (muraminidase) General function prediction only 114563602 Common - RepA domain protein Sfri_2432 2 None None None 114563677 Common - transcriptional regulator, LysR family protein Sfri_2509 152 COG0583 LysR, Transcriptional regulator Transcription 114562212 Common - hypothetical protein Sfri_1034 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 114564886 Common - ribonuclease G Sfri_3734 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 114563698 Common - ATPase associated with various cellular activities, AAA_3 Sfri_2530 175 COG0714 COG0714, MoxR-like ATPases General function prediction only 114563493 Common - hypothetical protein Sfri_2322 43 COG3304 COG3304, Predicted membrane protein Function unknown 114564030 Common - putative oxygen-independent coproporphyrinogen III oxidase Sfri_2866 205 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 114563517 Common - succinate dehydrogenase, cytochrome b subunit Sfri_2346 44 COG2142 SdhD, Succinate dehydrogenase, hydrophobic anchor subunit Energy production and conversion 114562466 Common - hypothetical protein Sfri_1288 3 None None None 114562771 Common - protein of unknown function DUF748 Sfri_1595 44 None None None 114563318 Common - protein of unknown function DUF1315 Sfri_2147 20 COG3139 COG3139, Uncharacterized protein conserved in bacteria Function unknown 114564495 Common - hypothetical protein Sfri_3334 22 COG5345 COG5345, Uncharacterized protein conserved in bacteria Function unknown 114562646 Common - acetate--CoA ligase Sfri_1469 215 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 114564355 Common pntA NAD(P) transhydrogenase subunit alpha Sfri_3194 166 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 114563056 Common - hypothetical protein Sfri_1885 1 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 114561240 Common - hypothetical protein Sfri_0052 6 None None None 114564058 Common - transcriptional regulator, ArsR family protein Sfri_2894 165 COG0640 ArsR, Predicted transcriptional regulators Transcription 114562053 Common - transport system permease protein Sfri_0875 192 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 114561213 Common - Peptidoglycan-binding LysM Sfri_0025 47 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 114564473 Common - tRNA delta(2)-isopentenylpyrophosphate transferase Sfri_3312 214 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 114562859 Common - hypothetical protein Sfri_1683 13 None None None 114564878 Nonpathogen - hypothetical protein Sfri_3726 2 None None None 114561980 Common - 2-dehydropantoate 2-reductase Sfri_0800 71 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 114564027 Common - hypothetical protein Sfri_2863 77 COG1872 COG1872, Uncharacterized conserved protein Function unknown 114564308 Common - transposase, IS4 family protein Sfri_3147 17 None None None 114561546 Common - histidine kinase, dimerisation and phosphoacceptor region Sfri_0358 70 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 114564022 Common - twitching motility protein PilU Sfri_2858 96 COG5008 PilU, Tfp pilus assembly protein, ATPase PilU Cell motility and secretion / Intracellular trafficking and secretion 114564051 Common - hydroxymethylbutenyl pyrophosphate reductase Sfri_2887 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 114562621 Common - surface antigen (D15) Sfri_1444 121 COG0729 COG0729, Outer membrane protein Cell envelope biogenesis, outer membrane 114563466 Common - hypothetical protein Sfri_2295 22 COG3816 COG3816, Uncharacterized protein conserved in bacteria Function unknown 114562418 Common - Twin-arginine translocation pathway signal Sfri_1240 5 None None None 114562738 Common - ABC-2 type transporter Sfri_1562 118 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 114564781 Common - Glycine cleavage system regulatory protein-like protein Sfri_3629 14 COG2716 GcvR, Glycine cleavage system regulatory protein Amino acid transport and metabolism 114565176 Common rihA ribonucleoside hydrolase 1 Sfri_4026 88 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 114561298 Common - general secretion pathway protein I Sfri_0110 39 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 114561390 Nonpathogen - hypothetical protein Sfri_0202 1 None None None 114561977 Common - diguanylate cyclase with PAS/PAC sensor Sfri_0797 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114562306 Common - two component transcriptional regulator, winged helix family protein Sfri_1128 220 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114563323 Common - lipid kinase Sfri_2152 101 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 114564563 Common - hypothetical protein Sfri_3402 23 COG3248 Tsx, Nucleoside-binding outer membrane protein Cell envelope biogenesis, outer membrane 114562351 Common - flagellin domain protein Sfri_1173 118 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 114563242 Common - short chain dehydrogenase Sfri_2071 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114563820 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Sfri_2654 190 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114563093 Common - DTW domain containing protein Sfri_1922 30 COG3148 COG3148, Uncharacterized conserved protein Function unknown 114561206 Common - transcriptional regulator, ArsR family protein Sfri_0018 97 COG0640 ArsR, Predicted transcriptional regulators Transcription 114562651 Common - adenosylmethionine-8-amino-7-oxononanoate aminotransferase Sfri_1474 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 114563613 Common - anaerobic ribonucleoside triphosphate reductase Sfri_2443 100 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 114563979 Common - Redoxin domain protein Sfri_2815 51 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 114561443 Common - cytochrome c oxidase, subunit III Sfri_0255 159 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 114565115 Common - hypothetical protein Sfri_3965 10 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 114563574 Common - putative chaperone Sfri_2404 64 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 114565179 Common - hypothetical protein Sfri_4029 1 None None None 114563563 Common - hypothetical protein Sfri_2393 4 None None None 114562100 Common - inner membrane transport protein YdhC Sfri_0922 206 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 114562659 Common - transcriptional regulator, LysR family protein Sfri_1482 177 COG0583 LysR, Transcriptional regulator Transcription 114562428 Common - hypothetical protein Sfri_1250 100 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 114564845 Common - hypothetical protein Sfri_3693 7 None None None 114561923 Common - hypothetical protein Sfri_0740 2 None None None 114563643 Common - formate acetyltransferase Sfri_2473 59 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 114563383 Common - methyl-accepting chemotaxis sensory transducer Sfri_2212 151 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114565023 Common - Carboxymuconolactone decarboxylase Sfri_3873 92 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 114564270 Common - Methyltransferase type 12 Sfri_3108 43 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 114561716 Nonpathogen - hypothetical protein Sfri_0530 1 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 114564149 Common - major outer membrane lipoprotein, putative Sfri_2985 17 COG4238 COG4238, Murein lipoprotein Cell envelope biogenesis, outer membrane 114561378 Common - acetylornithine deacetylase Sfri_0190 194 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 114564096 Common - positive regulator of sigma E, RseC/MucC Sfri_2932 32 COG3086 RseC, Positive regulator of sigma E activity Signal transduction mechanisms 114562810 Common - Uncharacterised conserved protein UCP025560 Sfri_1634 26 COG3784 COG3784, Uncharacterized protein conserved in bacteria Function unknown 114562827 Common - hypothetical protein Sfri_1651 1 None None None 114562707 Common - DoxX family protein Sfri_1531 8 COG2259 COG2259, Predicted membrane protein Function unknown 114562214 Common - riboflavin synthase subunit alpha Sfri_1036 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 114562720 Common - Lysophospholipase-like protein Sfri_1544 23 COG2267 PldB, Lysophospholipase Lipid metabolism 114564365 Common - nucleoside-diphosphate-sugar epimerase Sfri_3204 52 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 114563107 Common - Transketolase, central region Sfri_1936 209 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 114564736 Common - TonB family protein Sfri_3584 53 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 114562682 Common - uroporphyrin-III C-methyltransferase Sfri_1506 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 114564277 Common - tRNA guanosine-2'-O-methyltransferase Sfri_3115 191 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 114565060 Common - hypothetical protein Sfri_3910 14 None None None 114563046 Nonpathogen - hypothetical protein Sfri_1874 1 None None None 114563128 Nonpathogen - hypothetical protein Sfri_1957 1 None None None 114564091 Common - DNA repair protein RecO Sfri_2927 61 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 114564036 Common trmB tRNA (guanine-N(7))-methyltransferase Sfri_2872 179 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 114561452 Nonpathogen - hypothetical protein Sfri_0264 1 None None None 114561673 Common - hypothetical protein Sfri_0486 8 None None None 114562546 Common - 3-beta hydroxysteroid dehydrogenase/isomerase Sfri_1368 206 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 114563542 Common - hypothetical protein Sfri_2372 21 COG3913 SciT, Uncharacterized protein conserved in bacteria Function unknown 114564859 Common - VacJ family lipoprotein Sfri_3707 94 COG2853 VacJ, Surface lipoprotein Cell envelope biogenesis, outer membrane 114563758 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Sfri_2592 165 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 114562615 Nonpathogen - hypothetical protein Sfri_1438 3 None None None 114563718 Common - periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family protein Sfri_2551 47 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 114564850 Common - anaerobic nitric oxide reductase transcription regulator Sfri_3698 169 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 114562039 Common - methyl-accepting chemotaxis sensory transducer Sfri_0861 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114562323 Common - host cell attachment-required protein Sfri_1145 25 COG5622 COG5622, Protein required for attachment to host cells Cell motility and secretion 114564076 Common - sigma 54 modulation protein/ribosomal protein S30EA Sfri_2912 61 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 114562988 Common - ABC transporter related Sfri_1813 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 114564265 Common - Poly(beta-D-mannuronate) lyase Sfri_3103 7 None None None 114561481 Common - NAD-dependent epimerase/dehydratase Sfri_0293 64 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 114564200 Common - NnrS family protein Sfri_3037 58 COG3213 NnrS, Uncharacterized protein involved in response to NO Inorganic ion transport and metabolism 114563337 Common - 4-alpha-glucanotransferase Sfri_2166 118 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 114563675 Common - major facilitator superfamily MFS_1 Sfri_2506 154 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 114563333 Common - glucose-1-phosphate adenylyltransferase Sfri_2162 192 COG0448 GlgC, ADP-glucose pyrophosphorylase Carbohydrate transport and metabolism 114563124 Common - type I restriction-modification system, M subunit Sfri_1953 159 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 114562107 Common - protein of unknown function DUF486 Sfri_0929 53 COG3169 COG3169, Uncharacterized protein conserved in bacteria Function unknown 114561956 Common - alpha/beta hydrolase fold Sfri_0775 23 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114564956 Common - UDP-N-acetylmuramoylalanine--D-glutamate ligase Sfri_3806 211 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 114562314 Common xseA exodeoxyribonuclease VII large subunit Sfri_1136 205 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 114564515 Common - 23S rRNA (guanosine-2'-O-)-methyltransferase Sfri_3354 215 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 114564668 Common - ABC-3 protein Sfri_3515 31 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 114562374 Common flhA flagellar biosynthesis protein A Sfri_1196 127 COG1298 FlhA, Flagellar biosynthesis pathway, component FlhA Cell motility and secretion / Intracellular trafficking and secretion 114561395 Common - transcriptional regulator, LysR family protein Sfri_0207 172 COG0583 LysR, Transcriptional regulator Transcription 114562978 Common - DsrE family protein Sfri_1803 43 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 114564445 Common - ABC transporter related Sfri_3284 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 114563431 Common trmU tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Sfri_2260 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 114564080 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Sfri_2916 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 114562012 Common - protein of unknown function DUF1456 Sfri_0834 31 COG4807 COG4807, Uncharacterized protein conserved in bacteria Function unknown 114564459 Common - Arginine N-succinyltransferase Sfri_3298 37 COG3138 AstA, Arginine/ornithine N-succinyltransferase beta subunit Amino acid transport and metabolism 114563993 Common - glucose-1-phosphate thymidylyltransferase Sfri_2829 233 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 114561288 Common - peptidase M14, carboxypeptidase A Sfri_0100 20 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 114562233 Common - 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Sfri_1055 189 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 114563712 Common - excinuclease ATPase subunit Sfri_2545 14 None None None 114562064 Common - pseudouridine synthase Sfri_0886 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 114564397 Common - branched-chain amino acid transport Sfri_3236 18 COG4392 COG4392, Predicted membrane protein Function unknown 114563726 Common - hypothetical protein Sfri_2559 115 COG1090 COG1090, Predicted nucleoside-diphosphate sugar epimerase General function prediction only 114565012 Common - transporter, hydrophobe/amphiphile efflux-1 (HAE1) family protein Sfri_3862 178 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 114561387 Common - Twin-arginine translocation pathway signal Sfri_0199 111 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 114562520 Common - Enoyl-CoA hydratase/isomerase Sfri_1342 131 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 114564595 Common - glutathione-dependent formaldehyde-activating enzyme Sfri_3438 16 COG3791 COG3791, Uncharacterized conserved protein Function unknown 114561762 Common - hypothetical protein Sfri_0576 21 None None None 114562071 Common - isochorismatase hydrolase Sfri_0893 73 COG1535 EntB, Isochorismate hydrolase Secondary metabolites biosynthesis, transport, and catabolism 114564228 Common - transcriptional regulator, MarR family protein Sfri_3065 14 COG1846 MarR, Transcriptional regulators Transcription 114563524 Nonpathogen - hypothetical protein Sfri_2354 1 None None None 114564550 Common - UbiD family decarboxylases Sfri_3389 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 114564769 Common - hypothetical protein Sfri_3617 3 None None None 114563180 Common - hypothetical protein Sfri_2009 5 None None None 114561353 Common rpsE 30S ribosomal protein S5 Sfri_0165 248 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 114563417 Common metG methionyl-tRNA synthetase Sfri_2246 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 114562464 Common - tRNA(Ile)-lysidine synthetase Sfri_1286 210 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 114561260 Common - small multidrug resistance protein Sfri_0072 144 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 114562693 Common - transcriptional regulator, LuxR family protein Sfri_1517 132 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 114563362 Common - hypothetical protein Sfri_2191 1 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 114564860 Common - hypothetical protein Sfri_3708 13 None None None 114563766 Common - peptidyl-prolyl cis-trans isomerase, cyclophilin type Sfri_2600 201 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 114563478 Common - Aldose 1-epimerase Sfri_2307 55 COG0676 COG0676, Uncharacterized enzymes related to aldose 1-epimerase Carbohydrate transport and metabolism 114562007 Common - protein of unknown function DUF1458 Sfri_0829 38 COG3360 COG3360, Uncharacterized conserved protein Function unknown 114564403 Common - Tetratricopeptide TPR_2 repeat protein Sfri_3242 26 COG3014 COG3014, Uncharacterized protein conserved in bacteria Function unknown 114562906 Common - hypothetical protein Sfri_1731 21 COG4798 COG4798, Predicted methyltransferase General function prediction only 114561596 Common - predicted kinase Sfri_0409 51 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 114561782 Nonpathogen - hypothetical protein Sfri_0597 1 None None None 114564046 Common - methylation site containing protein Sfri_2882 58 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 114562098 Common - short-chain dehydrogenase/reductase SDR Sfri_0920 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114562143 Common - Xanthine/uracil/vitamin C permease Sfri_0965 135 COG2252 COG2252, Permeases General function prediction only 114562365 Common - flagellar hook-length control protein Sfri_1187 50 COG3144 FliK, Flagellar hook-length control protein Cell motility and secretion 114563456 Common - NADH-ubiquinone oxidoreductase, chain 4L Sfri_2285 84 COG1006 MnhC, Multisubunit Na+/H+ antiporter, MnhC subunit Inorganic ion transport and metabolism 114562830 Common - replication P family protein Sfri_1654 9 None None None 114563743 Common pspB phage shock protein B Sfri_2577 23 None None None 114564199 Common - Nitrite reductase (cytochrome; ammonia-forming) Sfri_3036 40 COG3303 NrfA, Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit Inorganic ion transport and metabolism 114561580 Common - TonB-dependent receptor, plug Sfri_0392 119 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 114561588 Common - hypothetical protein Sfri_0401 3 None None None 114564338 Common - NTPase Sfri_3177 36 COG1986 COG1986, Uncharacterized conserved protein Function unknown 114561426 Common - two component transcriptional regulator, winged helix family protein Sfri_0238 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114565145 Common - transport-associated Sfri_3995 58 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 114564693 Common - amino acid carrier protein Sfri_3541 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 114563034 Common - sodium/hydrogen exchanger Sfri_1861 92 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 114563221 Common - transposase IS3/IS911 family protein Sfri_2050 50 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 114561878 Common - Serine-type D-Ala-D-Ala carboxypeptidase Sfri_0695 155 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 114562186 Common - hypothetical protein Sfri_1008 11 COG2267 PldB, Lysophospholipase Lipid metabolism 114565150 Nonpathogen - protein of unknown function DUF1328 Sfri_4000 1 COG5487 COG5487, Small integral membrane protein Function unknown 114561362 Common rplQ 50S ribosomal protein L17 Sfri_0174 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 114563607 Common - hypothetical protein Sfri_2437 2 COG3183 COG3183, Predicted restriction endonuclease Defense mechanisms 114562905 Common - hypothetical protein Sfri_1730 7 None None None 114562900 Common - permease Sfri_1725 100 COG0701 COG0701, Predicted permeases General function prediction only 114563896 Common - pyruvate carboxyltransferase Sfri_2731 206 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 114564991 Common - anaerobic C4-dicarboxylate transporter Sfri_3841 36 COG2704 DcuB, Anaerobic C4-dicarboxylate transporter General function prediction only 114564884 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Sfri_3732 199 COG0388 COG0388, Predicted amidohydrolase General function prediction only 114561705 Common - dienelactone hydrolase Sfri_0519 39 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 114562879 Common - YceI family protein Sfri_1704 12 COG2353 COG2353, Uncharacterized conserved protein Function unknown 114563734 Common - Arylesterase Sfri_2568 108 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 114563065 Common - phosphogluconate dehydratase Sfri_1894 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 114563270 Common - NADH:flavin oxidoreductase/NADH oxidase Sfri_2099 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 114565087 Common - transcriptional regulator, TetR family protein Sfri_3937 60 COG1309 AcrR, Transcriptional regulator Transcription 114563226 Common - GDSL-like lipase/acylhydrolase domain protein Sfri_2055 11 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 114561684 Common - transcriptional regulator, LysR family protein Sfri_0498 181 COG0583 LysR, Transcriptional regulator Transcription 114564267 Common - Cupin 2, conserved barrel domain protein Sfri_3105 39 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 114563780 Common - protein of unknown function DUF1282 Sfri_2614 24 None None None 114561536 Common - thioester dehydrase family protein Sfri_0348 22 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 114564916 Common - ATP-dependent protease peptidase subunit Sfri_3764 149 COG5405 HslV, ATP-dependent protease HslVU (ClpYQ), peptidase subunit Posttranslational modification, protein turnover, chaperones 114562786 Common - transposase IS3/IS911 family protein Sfri_1610 50 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 114564980 Common dut deoxyuridine 5'-triphosphate nucleotidohydrolase Sfri_3830 180 COG0756 Dut, dUTPase Nucleotide transport and metabolism 114562474 Nonpathogen - conserved putative secreted protein Sfri_1296 8 None None None 114565101 Common - MscS Mechanosensitive ion channel Sfri_3951 62 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 114562033 Common - conserved hypothetical cytosolic protein Sfri_0855 15 None None None 114562727 Common - transcriptional regulator, GntR family protein Sfri_1551 137 COG1802 GntR, Transcriptional regulators Transcription 114565008 Common - protein of unknown function DUF519 Sfri_3858 85 COG2961 ComJ, Protein involved in catabolism of external DNA General function prediction only 114564901 Common - TPR repeat-containing protein Sfri_3749 12 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 114561336 Common rplC 50S ribosomal protein L3 Sfri_0148 231 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 114561617 Common - diguanylate cyclase/phosphodiesterase Sfri_0430 155 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 114562442 Common - PTS system, glucose-like IIB subunint Sfri_1264 49 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 114564311 Common - glycine cleavage system protein H Sfri_3150 187 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 114562945 Common - methyl-accepting chemotaxis sensory transducer Sfri_1770 151 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114563286 Common - acyl-CoA dehydrogenase domain protein Sfri_2115 150 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 114563306 Common - ferredoxin Sfri_2135 43 COG0633 Fdx, Ferredoxin Energy production and conversion 114565134 Common - transcriptional regulator, TetR family protein Sfri_3984 97 COG1309 AcrR, Transcriptional regulator Transcription 114564376 Common - DEAD/DEAH box helicase domain protein Sfri_3215 237 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 114564504 Nonpathogen - Cupin 2, conserved barrel domain protein Sfri_3343 1 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 114564222 Common - hypothetical protein Sfri_3059 5 None None None 114561909 Common - hypothetical protein Sfri_0726 31 COG2912 COG2912, Uncharacterized conserved protein Function unknown 114562246 Common - putative lipoprotein Sfri_1068 17 None None None 114565001 Common - TonB-dependent siderophore receptor Sfri_3851 126 COG4772 FecA, Outer membrane receptor for Fe3+-dicitrate Inorganic ion transport and metabolism 114564209 Common - peptidase M24 Sfri_3046 247 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 114562529 Common - alpha/beta hydrolase fold Sfri_1351 27 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114564559 Common - transcriptional regulator, LysR family protein Sfri_3398 179 COG0583 LysR, Transcriptional regulator Transcription 114564643 Common - mercuric transport protein periplasmic component Sfri_3490 48 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 114562207 Common - acriflavin resistance protein Sfri_1029 182 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 114562276 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Sfri_1098 6 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 114564602 Common - phage integrase family protein Sfri_3446 40 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 114564800 Common - transcriptional regulator, AraC family protein Sfri_3648 20 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 114563771 Common - type III restriction enzyme, res subunit Sfri_2605 129 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 114565124 Common - hypothetical protein Sfri_3974 1 None None None 114562552 Common - NAD-dependent epimerase/dehydratase Sfri_1374 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 114563509 Common fur ferric uptake regulator Sfri_2338 194 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 114564121 Common - pyridine nucleotide-disulphide oxidoreductase dimerisation region Sfri_2957 244 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 114562074 Common - hypothetical protein Sfri_0896 2 None None None 114565042 Common - transcriptional regulator, LysR family protein Sfri_3892 180 COG0583 LysR, Transcriptional regulator Transcription 114565161 Common - transcriptional regulator/antitoxin, MazE Sfri_4011 14 COG2336 MazE, Growth regulator Signal transduction mechanisms 114561528 Common - 3-oxoacyl-(acyl carrier protein) synthase I Sfri_0340 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 114561608 Common - ketol-acid reductoisomerase Sfri_0421 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 114563047 Common - Rhomboid family protein Sfri_1875 18 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 114561402 Common - hypothetical protein Sfri_0214 6 None None None 114564415 Common - anaerobic nitric oxide reductase transcription regulator Sfri_3254 168 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 114561521 Common - thioesterase domain, putative Sfri_0333 32 None None None 114561888 Common leuS leucyl-tRNA synthetase Sfri_0705 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 114564768 Common - transposase IS3/IS911 family protein Sfri_3616 50 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 114564974 Common - RarD protein, DMT superfamily transporter Sfri_3824 101 COG2962 RarD, Predicted permeases General function prediction only 114563867 Common tgt queuine tRNA-ribosyltransferase Sfri_2702 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 114562568 Common - beta-ketoacyl synthase Sfri_1391 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 114562586 Common - nitroreductase Sfri_1409 77 COG0778 NfnB, Nitroreductase Energy production and conversion 114564809 Common - NERD domain protein Sfri_3657 10 None None None 114561887 Common - Rare lipoprotein B Sfri_0704 37 COG2980 RlpB, Rare lipoprotein B Cell envelope biogenesis, outer membrane 114565084 Common - glycosyl transferase, family 9 Sfri_3934 87 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 114563355 Common aspS aspartyl-tRNA synthetase Sfri_2184 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 114563410 Common - DNA polymerase III, delta prime subunit Sfri_2239 85 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 114565214 Common - protein of unknown function DUF37 Sfri_4064 185 COG0759 COG0759, Uncharacterized conserved protein Function unknown 114564042 Common - NADH dehydrogenase Sfri_2878 162 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 114562758 Common - nitric oxide reductase Sfri_1582 229 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 114562890 Common - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase Sfri_1715 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 114562301 Common - cytochrome B561 Sfri_1123 5 None None None 114563369 Common - thiamine biosynthesis protein ThiS Sfri_2198 8 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 114564261 Common - methylation site containing protein Sfri_3099 8 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 114565002 Common - methyl-accepting chemotaxis sensory transducer Sfri_3852 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114564936 Common - type II secretion system protein Sfri_3784 143 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 114561647 Common - thioredoxin Sfri_0460 232 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 114562915 Common - hypothetical protein Sfri_1740 74 COG2983 COG2983, Uncharacterized conserved protein Function unknown 114563624 Common - short-chain dehydrogenase/reductase SDR Sfri_2454 208 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 114564331 Common - two component transcriptional regulator, LuxR family protein Sfri_3170 191 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 114562893 Common - histidinol-phosphate aminotransferase Sfri_1718 232 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 114564006 Common - hypothetical protein Sfri_2842 31 None None None 114563767 Common - UDP-2,3-diacylglucosamine hydrolase Sfri_2601 73 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 114564364 Common - nitroreductase Sfri_3203 48 COG0778 NfnB, Nitroreductase Energy production and conversion 114564824 Common - Alcohol dehydrogenase, zinc-binding domain protein Sfri_3672 194 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 114564392 Common - ABC-2 type transporter Sfri_3231 165 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 114564239 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Sfri_3077 157 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 114562250 Common - glutamate--cysteine ligase Sfri_1072 58 COG2918 GshA, Gamma-glutamylcysteine synthetase Coenzyme metabolism 114563150 Common - Rhodanese domain protein Sfri_1979 142 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 114562757 Common - tellurite resistance protein TehB Sfri_1581 16 COG3615 TehB, Uncharacterized protein/domain, possibly involved in tellurite resistance Inorganic ion transport and metabolism 114563110 Common - methyl-accepting chemotaxis sensory transducer Sfri_1939 157 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114563752 Common - flavocytochrome c Sfri_2586 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 114563218 Common - alpha/beta hydrolase fold Sfri_2047 40 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114564421 Common - diguanylate cyclase with GAF sensor Sfri_3260 185 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114564574 Nonpathogen - hypothetical protein Sfri_3413 5 None None None 114563634 Common - putative sulfate transport protein CysZ Sfri_2464 44 COG2981 CysZ, Uncharacterized protein involved in cysteine biosynthesis Amino acid transport and metabolism 114564817 Common - CutA1 divalent ion tolerance protein Sfri_3665 117 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 114561857 Common - ISSod10, transposase OrfB Sfri_0672 39 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 114562457 Common - outer membrane chaperone Skp (OmpH) Sfri_1279 80 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 114562349 Common flgL flagellar hook-associated protein FlgL Sfri_1171 100 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 114561683 Common - hypothetical protein Sfri_0497 1 None None None 114562792 Common - amidase Sfri_1616 219 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 114564354 Common - sulfite reductase (NADPH) flavoprotein, alpha chain Sfri_3193 106 COG0369 CysJ, Sulfite reductase, alpha subunit (flavoprotein) Inorganic ion transport and metabolism 114563001 Common - transmembrane pair domain protein Sfri_1826 41 COG4125 COG4125, Predicted membrane protein Function unknown 114564752 Common - short-chain dehydrogenase/reductase SDR Sfri_3600 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114564119 Common - hypothetical protein Sfri_2955 6 None None None 114562584 Common - ABC transporter related Sfri_1407 249 COG1119 ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA Inorganic ion transport and metabolism 114563760 Common - ATP-dependent protease La Sfri_2594 213 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 114563598 Common - inositol monophosphatase Sfri_2428 216 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 114565126 Common - transcriptional regulator, GntR family protein Sfri_3976 107 COG1725 COG1725, Predicted transcriptional regulators Transcription 114562843 Nonpathogen - hypothetical protein Sfri_1667 1 None None None 114563694 Common - putative sulfite oxidase subunit YedZ Sfri_2526 73 COG2717 COG2717, Predicted membrane protein Function unknown 114562616 Common - histone family protein DNA-binding protein Sfri_1439 188 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 114564614 Common - hypothetical protein Sfri_3458 1 None None None 114564546 Common - hypothetical protein Sfri_3385 2 None None None 114561630 Common - hypothetical protein Sfri_0443 1 None None None 114561329 Common - DNA-directed RNA polymerase, beta subunit Sfri_0141 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 114563499 Common - Lysine exporter protein (LYSE/YGGA) Sfri_2328 101 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 114562368 Common fliN flagellar motor switch protein Sfri_1190 122 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 114563494 Common - protein of unknown function DUF55 Sfri_2323 94 COG2947 COG2947, Uncharacterized conserved protein Function unknown 114562675 Common - 3-oxoacyl-(acyl-carrier-protein) reductase Sfri_1499 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114565040 Common - transcriptional regulator, LuxR family protein Sfri_3890 9 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 114561637 Common - Hemerythrin HHE cation binding domain protein Sfri_0450 45 COG2846 COG2846, Regulator of cell morphogenesis and NO signaling Cell division and chromosome partitioning 114563914 Common - histone family protein nucleoid-structuring protein H-NS Sfri_2749 27 COG2916 Hns, DNA-binding protein H-NS General function prediction only 114563205 Common - hypothetical protein Sfri_2034 3 None None None 114561409 Common - cytochrome C oxidase subunit IV Sfri_0221 55 COG3125 CyoD, Heme/copper-type cytochrome/quinol oxidase, subunit 4 Energy production and conversion 114563901 Nonpathogen - multiple resistance and pH regulation protein F Sfri_2736 6 COG2212 MnhF, Multisubunit Na+/H+ antiporter, MnhF subunit Inorganic ion transport and metabolism 114564126 Common - CDP-alcohol phosphatidyltransferase Sfri_2962 47 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 114563583 Common - hypothetical protein Sfri_2413 2 None None None 114562205 Common - diguanylate cyclase/phosphodiesterase Sfri_1027 184 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114563427 Common - cold-shock DNA-binding domain protein Sfri_2256 179 COG1278 CspC, Cold shock proteins Transcription 114562499 Common - fructokinase Sfri_1321 113 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 114564524 Common - periplasmic serine protease DegS Sfri_3363 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 114564111 Common - putative adenylate/guanylate cyclase Sfri_2947 21 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 114565090 Common - Rhodanese domain protein Sfri_3940 138 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 114563210 Common - acyl-CoA dehydrogenase domain protein Sfri_2039 148 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 114561725 Common - protein of unknown function DUF342 Sfri_0539 37 COG1315 COG1315, Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain DNA replication, recombination, and repair 114563880 Common - TRAP dicarboxylate transporter, DctP subunit Sfri_2715 97 COG1638 DctP, TRAP-type C4-dicarboxylate transport system, periplasmic component Carbohydrate transport and metabolism 114564931 Common - regulatory protein AmpE Sfri_3779 20 COG3725 AmpE, Membrane protein required for beta-lactamase induction Defense mechanisms 114563440 Common - hypothetical protein Sfri_2269 1 None None None 114563651 Common - sodium:dicarboxylate symporter Sfri_2481 163 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 114565026 Common - hypothetical protein Sfri_3876 1 None None None 114562391 Common - Succinylglutamate desuccinylase/aspartoacylase Sfri_1213 54 COG3608 COG3608, Predicted deacylase General function prediction only 114563313 Common - haloacid dehalogenase, type II Sfri_2142 67 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 114563439 Common - putative signal transduction protein with CBS domains Sfri_2268 103 COG0517 COG0517, FOG: CBS domain General function prediction only 114564186 Common - methylmalonate-semialdehyde dehydrogenase Sfri_3023 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 114564940 Common - protein of unknown function DUF329 Sfri_3788 59 COG3024 COG3024, Uncharacterized protein conserved in bacteria Function unknown 114561884 Common - iojap-like protein Sfri_0701 201 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 114561268 Common - methyl-accepting chemotaxis sensory transducer Sfri_0080 153 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114562271 Common - Sel1 domain protein repeat-containing protein Sfri_1093 51 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 114562528 Common - hypothetical protein Sfri_1350 5 None None None 114561228 Common - protein of unknown function DUF885 Sfri_0040 44 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 114563198 Common - initiation factor 3 Sfri_2027 211 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 114561514 Common - response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Sfri_0326 52 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114562010 Common - hypothetical protein Sfri_0832 2 None None None 114561490 Common - amidohydrolase Sfri_0302 166 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 114564997 Common - glucosyltransferase MdoH Sfri_3847 59 COG2943 MdoH, Membrane glycosyltransferase Cell envelope biogenesis, outer membrane 114561831 Common - S-adenosylmethionine synthetase Sfri_0646 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 114561960 Common - Deoxyribodipyrimidine photo-lyase Sfri_0779 131 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 114563403 Common - Paraquat-inducible protein A Sfri_2232 54 COG2995 PqiA, Uncharacterized paraquat-inducible protein A Function unknown 114562745 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Sfri_1569 196 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114561377 Common - phosphoenolpyruvate carboxylase Sfri_0189 116 COG2352 Ppc, Phosphoenolpyruvate carboxylase Energy production and conversion 114563593 Common - scaffold protein Sfri_2423 154 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 114561497 Nonpathogen - protein of unknown function UPF0057 Sfri_0309 7 COG0401 COG0401, Uncharacterized homolog of Blt101 Function unknown 114563262 Common - phosphoadenosine phosphosulfate reductase Sfri_2091 33 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 114563840 Common - hypothetical protein Sfri_2675 1 None None None 114561918 Common - cold-shock DNA-binding domain protein Sfri_0735 181 COG1278 CspC, Cold shock proteins Transcription 114562187 Common - type IV pilus assembly PilZ Sfri_1009 7 None None None 114564293 Common - hypothetical protein Sfri_3131 4 None None None 114564988 Common - hypothetical protein Sfri_3838 9 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 114563015 Common - transcriptional regulator, TetR family protein Sfri_1841 78 COG1309 AcrR, Transcriptional regulator Transcription 114561926 Common - lipid-transfer protein Sfri_0743 156 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 114562811 Common - hypothetical protein Sfri_1635 21 None None None 114563872 Common - sodium:dicarboxylate symporter Sfri_2707 156 COG3633 SstT, Na+/serine symporter Amino acid transport and metabolism 114563189 Common - fumarate/nitrate reduction transcriptional regulator Sfri_2018 162 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 114561413 Common - hypothetical protein Sfri_0225 1 None None None 114562606 Common - anthranilate synthase component I Sfri_1429 221 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 114561823 Common - ABC transporter related Sfri_0638 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 114561658 Common - twin-arginine translocation protein, TatB subunit Sfri_0471 31 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 114561252 Common - alpha/beta hydrolase fold Sfri_0064 156 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114562941 Common - hypothetical protein Sfri_1766 115 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 114564620 Common - Resolvase, N-terminal domain protein Sfri_3464 120 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 114562193 Common - hypothetical protein Sfri_1015 34 COG3154 COG3154, Putative lipid carrier protein Lipid metabolism 114563395 Common - protein of unknown function DUF1329 Sfri_2224 19 None None None 114563039 Common - efflux transporter, RND family, MFP subunit Sfri_1866 164 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 114562054 Common cobT nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Sfri_0876 118 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 114564827 Common - periplasmic sensor signal transduction histidine kinase Sfri_3675 145 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114563032 Common - aconitate hydratase Sfri_1859 223 COG1048 AcnA, Aconitase A Energy production and conversion 114564346 Common - TrkA-C domain protein Sfri_3185 107 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 114564981 Common slmA nucleoid occlusion protein Sfri_3831 58 COG1309 AcrR, Transcriptional regulator Transcription 114565183 Nonpathogen - PepSY-associated TM helix domain protein Sfri_4033 4 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 114563420 Nonpathogen - hypothetical protein Sfri_2249 2 None None None 114562085 Common - hypothetical protein Sfri_0907 1 None None None 114562737 Common - ABC transporter related Sfri_1561 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 114562463 Common dnaE DNA polymerase III subunit alpha Sfri_1285 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 114561364 Common - Heme exporter protein D (CcmD) Sfri_0176 23 COG3114 CcmD, Heme exporter protein D Intracellular trafficking and secretion 114562026 Common - ribose-5-phosphate isomerase A Sfri_0848 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 114561622 Common - ABC transporter related Sfri_0435 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 114561433 Common - peptidylprolyl isomerase, FKBP-type Sfri_0245 140 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 114561569 Common - Ribulose-phosphate 3-epimerase Sfri_0381 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 114562125 Common - S-ribosylhomocysteinase Sfri_0947 55 COG1854 LuxS, LuxS protein involved in autoinducer AI2 synthesis Signal transduction mechanisms 114561237 Common - flagellar basal body-associated protein FliL-like protein Sfri_0049 17 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 114564428 Common - hypothetical protein Sfri_3267 4 None None None 114562926 Common - DNA replication initiation factor Sfri_1751 195 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 114562865 Common - hypothetical protein Sfri_1689 11 None None None 114564782 Common - GPR1/FUN34/yaaH family protein Sfri_3630 52 COG1584 COG1584, Predicted membrane protein Function unknown 114561310 Common - phospholipid/glycerol acyltransferase Sfri_0122 156 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 114564386 Common - TonB-dependent siderophore receptor Sfri_3225 106 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 114564659 Common - Alpha,alpha-trehalase Sfri_3506 27 COG1626 TreA, Neutral trehalase Carbohydrate transport and metabolism 114565197 Common - F0F1 ATP synthase subunit alpha Sfri_4047 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 114563485 Common - hypothetical protein Sfri_2314 9 None None None 114563849 Common - RNA polymerase sigma factor Sfri_2684 157 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 114563434 Common - Cupin 4 family protein Sfri_2263 62 COG2850 COG2850, Uncharacterized conserved protein Function unknown 114564702 Common metL bifunctional aspartate kinase II/homoserine dehydrogenase II Sfri_3550 235 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 114561806 Common - nitrate/nitrite sensor protein NarQ Sfri_0621 141 COG3850 NarQ, Signal transduction histidine kinase, nitrate/nitrite-specific Signal transduction mechanisms 114564066 Common - hypothetical protein Sfri_2902 1 None None None 114563934 Common - porin, Gram-negative type Sfri_2769 44 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 114564627 Common - plasmid stabilization system Sfri_3471 21 COG3668 ParE, Plasmid stabilization system protein General function prediction only 114562599 Common - intracellular septation protein A Sfri_1422 92 COG2917 COG2917, Intracellular septation protein A Cell division and chromosome partitioning 114564371 Common - Na(+)-translocating NADH-quinone reductase subunit B Sfri_3210 75 COG1805 NqrB, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB Energy production and conversion 114562539 Common - hypothetical protein Sfri_1361 15 COG2928 COG2928, Uncharacterized conserved protein Function unknown 114563105 Common - succinylglutamate desuccinylase Sfri_1934 24 COG2988 COG2988, Succinylglutamate desuccinylase Amino acid transport and metabolism 114563811 Common - hypothetical protein Sfri_2645 4 None None None 114564648 Common - phage integrase family protein Sfri_3495 10 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 114561317 Common - ISSod10, transposase OrfB Sfri_0129 36 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 114562175 Common prfC peptide chain release factor 3 Sfri_0997 249 COG4108 PrfC, Peptide chain release factor RF-3 Translation, ribosomal structure and biogenesis 114562510 Common - maleylacetoacetate isomerase Sfri_1332 73 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 114562295 Common - histidyl-tRNA synthetase Sfri_1117 249 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 114561876 Common - lipoate-protein ligase B Sfri_0693 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 114563707 Nonpathogen - hypothetical protein Sfri_2540 1 None None None 114562198 Common - two component, sigma54 specific, transcriptional regulator, Fis family protein Sfri_1020 216 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 114564723 Common - CMP/dCMP deaminase, zinc-binding Sfri_3571 79 COG2131 ComEB, Deoxycytidylate deaminase Nucleotide transport and metabolism 114561697 Common - flavocytochrome c Sfri_0511 222 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 114564255 Common - hypothetical protein Sfri_3093 7 None None None 114564054 Common - isoleucyl-tRNA synthetase Sfri_2890 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 114564654 Common - hypothetical protein Sfri_3501 19 None None None 114561995 Common - transcriptional regulator, LysR family protein Sfri_0815 170 COG0583 LysR, Transcriptional regulator Transcription 114564587 Common - hypothetical protein Sfri_3428 24 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 114563413 Common - aminotransferase, class IV Sfri_2242 164 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 114565210 Common - transcriptional regulator, LysR family protein Sfri_4060 184 COG0583 LysR, Transcriptional regulator Transcription 114564325 Common - putative thiol-disulphide oxidoreductase DCC Sfri_3164 24 COG3011 COG3011, Uncharacterized protein conserved in bacteria Function unknown 114562874 Common - arginine decarboxylase Sfri_1698 144 COG1166 SpeA, Arginine decarboxylase (spermidine biosynthesis) Amino acid transport and metabolism 114562132 Common - Na(+)-translocating NADH-quinone reductase subunit F Sfri_0954 155 COG2871 NqrF, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF Energy production and conversion 114565166 Common - hypothetical protein Sfri_4016 3 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 114563162 Common - periplasmic sensory protein associated with the TorRS two-component regulatory system Sfri_1991 15 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 114563647 Common - phosphate acetyltransferase Sfri_2477 176 COG0280 Pta, Phosphotransacetylase Energy production and conversion 114562885 Common - integration host factor, alpha subunit Sfri_1710 211 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 114563806 Common - transcriptional regulator, CdaR Sfri_2640 49 COG3835 CdaR, Sugar diacid utilization regulator Transcription / Signal transduction mechanisms 114562483 Common - Lysine exporter protein (LYSE/YGGA) Sfri_1305 111 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 114564162 Common - diguanylate cyclase Sfri_2999 180 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114561398 Common - aldo/keto reductase Sfri_0210 180 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 114561530 Common - tryptophan halogenase Sfri_0342 46 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 114564211 Common - Xanthine/uracil/vitamin C permease Sfri_3048 134 COG2252 COG2252, Permeases General function prediction only 114562006 Common - transcriptional regulator, LysR family protein Sfri_0826 182 COG0583 LysR, Transcriptional regulator Transcription 114564493 Common tolC outer membrane channel protein Sfri_3332 135 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 114564857 Common - anti-sigma-factor antagonist Sfri_3705 6 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 114561990 Common - hypothetical protein Sfri_0810 18 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 114563551 Common - efflux transporter, RND family, MFP subunit Sfri_2381 176 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 114561440 Common - hypothetical protein Sfri_0252 11 None None None 114565206 Common - tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA Sfri_4056 192 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 114562062 Nonpathogen - Prolyl 4-hydroxylase, alpha subunit Sfri_0884 9 COG3128 PiuC, Uncharacterized iron-regulated protein Function unknown 114562111 Common - hypothetical protein Sfri_0933 6 None None None 114561775 Common - dihydroorotase Sfri_0589 88 COG0418 PyrC, Dihydroorotase Nucleotide transport and metabolism 114562590 Common - hypothetical protein Sfri_1413 19 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 114563640 Common - formate/nitrite transporter Sfri_2470 101 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 114563077 Common - hypothetical protein Sfri_1906 25 COG1896 COG1896, Predicted hydrolases of HD superfamily General function prediction only 114562283 Common - protein of unknown function DUF980 Sfri_1105 58 COG3228 COG3228, Uncharacterized protein conserved in bacteria Function unknown 114561323 Common secE preprotein translocase subunit SecE Sfri_0135 69 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 114562532 Common - Lysine exporter protein (LYSE/YGGA) Sfri_1354 96 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 114563576 Common - conserved hypothetical protein 103 Sfri_2406 181 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 114562419 Common - hypothetical protein Sfri_1241 3 None None None 114565114 Common - protein of unknown function DUF885 Sfri_3964 44 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 114563025 Common - protein of unknown function DUF224, cysteine-rich region domain protein Sfri_1852 145 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 114563386 Common - short chain dehydrogenase Sfri_2215 235 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 114562821 Nonpathogen - hypothetical protein Sfri_1645 1 None None None 114562048 Common - lipase, class 3 Sfri_0870 6 COG3675 COG3675, Predicted lipase Lipid metabolism 114563532 Common - ATPase AAA-2 domain protein Sfri_2362 215 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 114564952 Common - Polypeptide-transport-associated domain protein, FtsQ-type Sfri_3802 81 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 114561798 Common - Polysulphide reductase, NrfD Sfri_0613 27 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 114565144 Nonpathogen - hypothetical protein Sfri_3994 1 None None None 114562123 Common - BolA family protein Sfri_0945 91 COG0271 BolA, Stress-induced morphogen (activity unknown) Signal transduction mechanisms 114564108 Common - PTSINtr with GAF domain, PtsP Sfri_2944 235 COG3605 PtsP, Signal transduction protein containing GAF and PtsI domains Signal transduction mechanisms 114561418 Common - aconitate hydratase 1 Sfri_0230 219 COG1048 AcnA, Aconitase A Energy production and conversion 114561659 Common - twin-arginine translocation protein, TatA/E family subunit Sfri_0472 54 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 114561809 Common - Rh family protein/ammonium transporter Sfri_0624 203 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 114562730 Common - Integrase, catalytic region Sfri_1554 75 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 114563244 Common - transcriptional regulator, LysR family protein Sfri_2073 125 COG0583 LysR, Transcriptional regulator Transcription 114564865 Common - peptidase M28 Sfri_3713 20 COG2234 Iap, Predicted aminopeptidases General function prediction only 114564917 Common hslU ATP-dependent protease ATP-binding subunit Sfri_3765 216 COG1220 HslU, ATP-dependent protease HslVU (ClpYQ), ATPase subunit Posttranslational modification, protein turnover, chaperones 114563470 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Sfri_2299 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 114564302 Common - hypothetical protein Sfri_3140 8 None None None 114564771 Common - protein of unknown function DUF1499 Sfri_3619 21 COG4446 COG4446, Uncharacterized protein conserved in bacteria Function unknown 114564441 Common - 3-methyl-2-oxobutanoate hydroxymethyltransferase Sfri_3280 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 114563165 Common - trimethylamine-N-oxide reductase TorA Sfri_1994 161 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 114562350 Common - flagellin domain protein Sfri_1172 122 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 114562475 Common - hypothetical protein Sfri_1297 29 None None None 114564172 Common - extracellular solute-binding protein, family 1 Sfri_3009 128 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 114564796 Common - protein of unknown function DUF6, transmembrane Sfri_3644 50 None None None 114562604 Common - anthranilate phosphoribosyltransferase Sfri_1427 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 114561744 Common - D-3-phosphoglycerate dehydrogenase Sfri_0558 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 114563888 Common - 1,4-dihydroxy-2-naphthoate octaprenyltransferase Sfri_2723 105 COG1575 MenA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase Coenzyme metabolism 114564402 Common - peptide deformylase Sfri_3241 213 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 114564196 Common - amine oxidase Sfri_3033 70 COG2907 COG2907, Predicted NAD/FAD-binding protein General function prediction only 114564893 Common - methylation site containing protein Sfri_3741 14 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 114564101 Common - hypothetical protein Sfri_2937 1 None None None 114564611 Common - outer membrane efflux protein Sfri_3455 44 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 114562431 Common - hypothetical protein Sfri_1253 5 None None None 114564064 Common - transaldolase B Sfri_2900 172 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 114563539 Common - Uncharacterised conserved protein UCP028301 Sfri_2369 50 COG3516 COG3516, Uncharacterized protein conserved in bacteria Function unknown 114562966 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Sfri_1791 180 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114563615 Common - DEAD/DEAH box helicase domain protein Sfri_2445 243 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 114561190 Common - DNA polymerase III, beta subunit Sfri_0002 214 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 114564521 Common rplM 50S ribosomal protein L13 Sfri_3360 234 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 114564580 Common - hypothetical protein Sfri_3419 7 None None None 114561472 Common - transcriptional regulator, AsnC family protein Sfri_0284 139 COG1522 Lrp, Transcriptional regulators Transcription 114563445 Common - putative signal-transduction protein with CBS domains Sfri_2274 41 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 114563057 Common - Smr protein/MutS2 Sfri_1886 72 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 114565056 Common - transcriptional regulator, Fis family protein Sfri_3906 179 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 114564156 Common - putative metalloendopeptidase, glycoprotease family protein Sfri_2992 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 114564316 Common - protein of unknown function DUF710 Sfri_3155 53 COG3027 COG3027, Uncharacterized protein conserved in bacteria Function unknown 114562448 Common rpsB 30S ribosomal protein S2 Sfri_1270 223 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 114561563 Common - Shikimate kinase Sfri_0375 201 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 114561210 Common - sun protein Sfri_0022 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 114561371 Common - periplasmic protein thiol--disulphide oxidoreductase DsbE Sfri_0183 128 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 114563917 Common - transferase hexapeptide repeat-containing protein Sfri_2752 220 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 114561338 Common rplW 50S ribosomal protein L23 Sfri_0150 150 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 114561907 Common - modification methylase, HemK family protein Sfri_0724 215 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 114562663 Common rbgA ribosomal biogenesis GTPase Sfri_1486 104 COG1161 COG1161, Predicted GTPases General function prediction only 114564378 Common - Pirin domain protein domain protein Sfri_3217 148 COG1741 COG1741, Pirin-related protein General function prediction only 114563797 Common - protein of unknown function DUF81 Sfri_2631 158 COG0730 COG0730, Predicted permeases General function prediction only 114564674 Common - MscS Mechanosensitive ion channel Sfri_3521 209 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 114563547 Common - FHA domain containing protein Sfri_2377 21 COG3456 COG3456, Uncharacterized conserved protein, contains FHA domain Signal transduction mechanisms 114564313 Common - Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family protein Sfri_3152 118 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 114562109 Common - hypothetical protein Sfri_0931 10 COG1416 COG1416, Uncharacterized conserved protein Function unknown 114563308 Nonpathogen - hypothetical protein Sfri_2137 4 None None None 114562912 Common - septum site-determining protein MinC Sfri_1737 106 COG0850 MinC, Septum formation inhibitor Cell division and chromosome partitioning 114562041 Nonpathogen - hypothetical protein Sfri_0863 1 None None None 114562461 Common lpxB lipid-A-disaccharide synthase Sfri_1283 139 COG0763 LpxB, Lipid A disaccharide synthetase Cell envelope biogenesis, outer membrane 114561897 Nonpathogen - hypothetical protein Sfri_0714 1 None None None 114563365 Common - hypothetical protein Sfri_2194 19 None None None 114564887 Common - maf protein Sfri_3735 197 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 114563898 Common - 3-oxoacid CoA-transferase, B subunit Sfri_2733 94 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 114564803 Common - Alpha/beta hydrolase fold-3 domain protein Sfri_3651 134 COG0657 Aes, Esterase/lipase Lipid metabolism 114562505 Common - UDP-glucose 4-epimerase Sfri_1327 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 114561522 Common - azoreductase Sfri_0334 98 COG1182 AcpD, Acyl carrier protein phosphodiesterase Lipid metabolism 114561590 Common - hypothetical protein Sfri_0403 1 None None None 114562765 Common - ErfK/YbiS/YcfS/YnhG family protein Sfri_1589 64 COG3034 COG3034, Uncharacterized protein conserved in bacteria Function unknown 114561886 Common - DNA polymerase III, delta subunit Sfri_0703 67 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 114563975 Common - hypothetical protein Sfri_2811 2 None None None 114564967 Common - 3-isopropylmalate dehydratase, small subunit Sfri_3817 209 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 114562760 Common - transcriptional regulator, LysR family protein Sfri_1584 182 COG0583 LysR, Transcriptional regulator Transcription 114561356 Common secY preprotein translocase subunit SecY Sfri_0168 239 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 114564044 Common - Prepilin-type cleavage/methylation-like protein Sfri_2880 27 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 114565131 Common - diguanylate cyclase Sfri_3981 179 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114563358 Common - putative methyltransferase Sfri_2187 58 COG0500 SmtA, SAM-dependent methyltransferases Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114561731 Common - protein of unknown function DUF335, SprT Sfri_0545 26 COG3091 SprT, Uncharacterized protein conserved in bacteria Function unknown 114562684 Common - response regulator receiver and ANTAR domain protein Sfri_1508 6 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 114562163 Common - phosphoglucosamine mutase Sfri_0985 241 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 114562796 Nonpathogen - hypothetical protein Sfri_1620 1 None None None 114562386 Common - hypothetical protein Sfri_1208 13 None None None 114563265 Common - hypothetical protein Sfri_2094 13 None None None 114561302 Common - General secretion pathway M protein Sfri_0114 22 COG3149 PulM, Type II secretory pathway, component PulM Intracellular trafficking and secretion 114562031 Common - Negative transcriptional regulator Sfri_0853 61 COG2808 PaiB, Transcriptional regulator Transcription 114562668 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Sfri_1492 190 COG0546 Gph, Predicted phosphatases General function prediction only 114564142 Common - Cl- channel, voltage-gated family protein Sfri_2978 154 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 114564417 Common - protein of unknown function DUF583 Sfri_3256 3 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 114562805 Common - drug resistance transporter, Bcr/CflA subfamily Sfri_1629 168 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 114562942 Common - glucose-specific PTS system component Sfri_1767 60 COG2190 NagE, Phosphotransferase system IIA components Carbohydrate transport and metabolism 114563800 Common - histone deacetylase superfamily Sfri_2634 159 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 114563527 Nonpathogen - hypothetical protein Sfri_2357 1 None None None 114564366 Common - hypothetical protein Sfri_3205 1 None None None 114564880 Common - hypothetical protein Sfri_3728 27 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 114561529 Common - hypothetical protein Sfri_0341 10 None None None 114563783 Common - FeoA family protein Sfri_2617 15 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 114563145 Common - putative DNA-binding protein Sfri_1974 30 COG1342 COG1342, Predicted DNA-binding proteins General function prediction only 114562555 Common - glycosyl transferase, group 1 Sfri_1377 197 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 114563141 Common - copper resistance B precursor Sfri_1970 42 COG3667 PcoB, Uncharacterized protein involved in copper resistance Inorganic ion transport and metabolism 114563515 Common sdhB succinate dehydrogenase iron-sulfur subunit Sfri_2344 201 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 114563508 Common - NAD-dependent deacetylase Sfri_2337 149 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 114562572 Common - tRNA pseudouridine synthase A Sfri_1395 237 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 114564762 Common - hypothetical protein Sfri_3610 9 None None None 114563325 Common - hypothetical protein Sfri_2154 158 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 114563411 Common - dTMP kinase Sfri_2240 224 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 114564835 Common - 4Fe-4S ferredoxin, iron-sulfur binding domain protein Sfri_3683 165 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 114563294 Common rpsA 30S ribosomal protein S1 Sfri_2123 216 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 114564203 Common - protein of unknown function DUF368 Sfri_3040 50 COG2035 COG2035, Predicted membrane protein Function unknown 114562157 Common secD preprotein translocase subunit SecD Sfri_0979 206 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 114562245 Common - sodium ion-translocating decarboxylase, beta subunit Sfri_1067 56 COG1883 OadB, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit Energy production and conversion 114564691 Common - ABC-2 type transporter Sfri_3539 193 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 114563476 Common - two component transcriptional regulator, LuxR family protein Sfri_2305 206 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 114561816 Common - hypothetical protein Sfri_0631 1 None None None 114561589 Common - hypothetical protein Sfri_0402 11 COG2930 COG2930, Uncharacterized conserved protein Function unknown 114562691 Common - Curlin associated repeat protein Sfri_1515 10 None None None 114561534 Common - Histidine ammonia-lyase Sfri_0346 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 114561291 Common - RNA-binding S4 domain protein Sfri_0103 96 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 114562141 Common - peptidase M17, leucyl aminopeptidase domain protein Sfri_0963 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 114563487 Common - response regulator receiver modulated CheW protein Sfri_2316 165 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 114562525 Common - hypothetical protein Sfri_1347 11 COG3608 COG3608, Predicted deacylase General function prediction only 114561599 Common - protein of unknown function DUF904 Sfri_0412 6 None None None 114561429 Common - hypothetical protein Sfri_0241 1 None None None 114564446 Common - hypothetical protein Sfri_3285 5 COG5589 COG5589, Uncharacterized conserved protein Function unknown 114562311 Common - Propeptide, PepSY amd peptidase M4 Sfri_1133 2 COG3212 COG3212, Predicted membrane protein Function unknown 114563381 Common - ribonuclease activity regulator protein RraA Sfri_2210 97 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 114564698 Common - cytochrome c family protein Sfri_3546 60 COG2863 COG2863, Cytochrome c553 Energy production and conversion 114562573 Common - FolC bifunctional protein Sfri_1396 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 114562019 Common - hypothetical protein Sfri_0841 4 None None None 114563777 Common - tRNA hydroxylase Sfri_2611 40 COG4445 MiaE, Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 114561247 Common - formate dehydrogenase, gamma subunit Sfri_0059 67 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 114562070 Common - SEC-C motif domain protein Sfri_0892 29 COG3318 COG3318, Predicted metal-binding protein related to the C-terminal domain of SecA General function prediction only 114564721 Common - monofunctional biosynthetic peptidoglycan transglycosylase Sfri_3569 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 114562519 Common - enoyl-CoA hydratase Sfri_1341 186 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 114562903 Common - peptidase M22, glycoprotease Sfri_1728 195 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 114563720 Common - periplasmic nitrate reductase, large subunit Sfri_2553 185 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 114563461 Common - putative monovalent cation/H+ antiporter subunit D Sfri_2290 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 114563786 Common - protein of unknown function DUF885 Sfri_2620 43 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 114563855 Common - hypothetical protein Sfri_2690 34 None None None 114565035 Common - phosphate transporter Sfri_3885 140 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 114564422 Common - (Glutamate--ammonia-ligase) adenylyltransferase Sfri_3261 119 COG1391 GlnE, Glutamine synthetase adenylyltransferase Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms 114561865 Common - anaerobic c4-dicarboxylate antiporter, Dcu family protein Sfri_0681 37 COG2704 DcuB, Anaerobic C4-dicarboxylate transporter General function prediction only 114563862 Common - hypothetical protein Sfri_2697 16 None None None 114563276 Common - Ni/Fe-hydrogenase, b-type cytochrome subunit Sfri_2105 49 COG1969 HyaC, Ni,Fe-hydrogenase I cytochrome b subunit Energy production and conversion 114562008 Common - putative iron-sulfur cluster binding protein Sfri_0830 126 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 114565103 Common - urocanate hydratase Sfri_3953 97 COG2987 HutU, Urocanate hydratase Amino acid transport and metabolism 114564669 Common - periplasmic solute binding protein Sfri_3516 100 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 114563014 Common - Ferritin, Dps family protein Sfri_1840 133 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 114564662 Common - hypothetical protein Sfri_3509 2 None None None 114563645 Common - protein of unknown function DUF412 Sfri_2475 23 COG3092 COG3092, Uncharacterized protein conserved in bacteria Function unknown 114565205 Common gidB glucose-inhibited division protein B Sfri_4055 201 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 114562512 Common - outer membrane protein W Sfri_1334 69 COG3047 OmpW, Outer membrane protein W Cell envelope biogenesis, outer membrane 114561420 Common - acetoin reductases Sfri_0232 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114564743 Common - hypothetical protein Sfri_3591 1 None None None 114562260 Common - hypothetical protein Sfri_1082 3 None None None 114563370 Common - UBA/THIF-type NAD/FAD binding protein Sfri_2199 212 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 114564706 Common - cytochrome c family protein Sfri_3554 2 COG3258 COG3258, Cytochrome c Energy production and conversion 114563911 Common - Na+/H+ antiporter NhaC Sfri_2746 66 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 114564048 Common - type IV pilus assembly protein PilX Sfri_2884 1 COG4726 PilX, Tfp pilus assembly protein PilX Cell motility and secretion / Intracellular trafficking and secretion 114564906 Common - hypothetical protein Sfri_3754 4 None None None 114562211 Common glyA serine hydroxymethyltransferase Sfri_1033 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 114562231 Common - Septum formation initiator Sfri_1053 64 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 114562476 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Sfri_1298 6 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 114563958 Common - L-lactate permease Sfri_2793 103 COG1620 LldP, L-lactate permease Energy production and conversion 114561487 Common - DTW domain containing protein Sfri_0299 37 COG3148 COG3148, Uncharacterized conserved protein Function unknown 114562088 Common - UTP-GlnB uridylyltransferase, GlnD Sfri_0910 123 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 114564517 Common - Sel1 domain protein repeat-containing protein Sfri_3356 26 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 114561545 Common - two component transcriptional regulator, LuxR family protein Sfri_0357 215 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 114562995 Common proX glycine betaine transporter periplasmic subunit Sfri_1820 41 COG2113 ProX, ABC-type proline/glycine betaine transport systems, periplasmic components Amino acid transport and metabolism 114564954 Common - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Sfri_3804 208 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 114563678 Common - tetraheme cytochrome c Sfri_2510 8 None None None 114562540 Common - hypothetical protein Sfri_1362 26 None None None 114561945 Common - sodium/proline symporter Sfri_0764 168 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 114563331 Common - TonB-dependent receptor, plug Sfri_2160 97 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 114562986 Common - cyclic nucleotide-binding protein Sfri_1811 119 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 114563044 Common - methylated-DNA-(protein)-cysteine S-methyltransferase Sfri_1872 60 COG3695 COG3695, Predicted methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 114564482 Common - MscS Mechanosensitive ion channel Sfri_3321 219 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 114562274 Common - protein of unknown function UPF0125 Sfri_1096 63 COG2914 COG2914, Uncharacterized protein conserved in bacteria Function unknown 114561203 Common - protein of unknown function UPF0029 Sfri_0015 131 COG1739 COG1739, Uncharacterized conserved protein Function unknown 114564220 Common - H+transporting two-sector ATPase, gamma subunit Sfri_3057 197 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 114564502 Common - tRNA-dihydrouridine synthase A Sfri_3341 208 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 114564731 Common - putative integral membrane protein Sfri_3579 14 None None None 114562614 Common - Pseudouridine synthase, Rsu Sfri_1437 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 114563174 Common - GreA/GreB family elongation factor Sfri_2003 94 COG0782 GreA, Transcription elongation factor Transcription 114561201 Common fadB multifunctional fatty acid oxidation complex subunit alpha Sfri_0013 189 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 114561381 Common - ornithine carbamoyltransferase Sfri_0193 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 114562634 Common - OmpA/MotB domain protein Sfri_1457 113 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 114561905 Common hemA glutamyl-tRNA reductase Sfri_0722 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 114561502 Common - cation diffusion facilitator family transporter Sfri_0314 208 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 114561392 Common - PepSY-associated TM helix domain protein Sfri_0204 48 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 114562327 Common - transcriptional regulator, TetR family protein Sfri_1149 122 COG1309 AcrR, Transcriptional regulator Transcription 114563178 Common - phage integrase family protein Sfri_2007 26 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 114562170 Common - tRNA pseudouridine synthase B Sfri_0992 245 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 114563725 Common folX D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase Sfri_2558 34 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 114561935 Common - hypothetical protein Sfri_0753 2 None None None 114562258 Common - peptidase S41 Sfri_1080 54 COG4946 COG4946, Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system Function unknown 114564077 Common - chorismate mutase Sfri_2913 222 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 114565049 Common - protein of unknown function DUF347 Sfri_3899 27 COG4705 COG4705, Uncharacterized membrane-anchored protein conserved in bacteria Function unknown 114564652 Common - hypothetical protein Sfri_3499 1 None None None 114565014 Common - outer membrane protein RomA Sfri_3864 102 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 114563540 Common - ImpA domain protein Sfri_2370 30 COG3515 COG3515, Uncharacterized protein conserved in bacteria Function unknown 114562961 Common - tryptophan halogenase Sfri_1786 16 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 114562037 Common - (2Fe-2S)-binding domain protein Sfri_0859 121 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 114561346 Common rplN 50S ribosomal protein L14 Sfri_0158 247 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 114564179 Common - transposase IS3/IS911 family protein Sfri_3016 50 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 114562265 Common - hypothetical protein Sfri_1087 2 None None None 114561855 Common - hypothetical protein Sfri_0670 4 None None None 114564384 Common - hypothetical protein Sfri_3223 4 None None None 114563998 Common - polysaccharide biosynthesis protein Sfri_2834 16 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 114561369 Common - TPR repeat-containing protein Sfri_0181 68 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 114565198 Common - ATP synthase F1, delta subunit Sfri_4048 172 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 114562325 Common - acriflavin resistance protein Sfri_1147 178 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 114562376 Common - Cobyrinic acid a,c-diamide synthase Sfri_1198 171 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 114564912 Common - hypothetical protein Sfri_3760 1 COG3170 FimV, Tfp pilus assembly protein FimV Cell motility and secretion / Intracellular trafficking and secretion 114563482 Common - hypothetical protein Sfri_2311 3 None None None 114564460 Common argD bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein Sfri_3299 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 114562421 Nonpathogen - hypothetical protein Sfri_1243 1 None None None 114563130 Common - protein of unknown function DUF330 Sfri_1959 6 COG3009 COG3009, Uncharacterized protein conserved in bacteria Function unknown 114561282 Nonpathogen - protein of unknown function UPF0057 Sfri_0094 1 COG0401 COG0401, Uncharacterized homolog of Blt101 Function unknown 114564657 Common - transcriptional regulator, LacI family protein Sfri_3504 126 COG1609 PurR, Transcriptional regulators Transcription 114563716 Common - TonB-dependent siderophore receptor Sfri_2549 108 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 114563569 Common - transcription-repair coupling factor Sfri_2399 234 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 114561979 Common - transcriptional regulator, CadC Sfri_0799 62 COG3710 CadC, DNA-binding winged-HTH domains Transcription 114564471 Common - GTP-binding protein, HSR1-related Sfri_3310 234 COG2262 HflX, GTPases General function prediction only 114563589 Common - ferredoxin, 2Fe-2S type, ISC system Sfri_2419 68 COG0633 Fdx, Ferredoxin Energy production and conversion 114562486 Common - hypothetical protein Sfri_1308 6 None None None 114563561 Common - transcriptional regulator, MarR family protein Sfri_2391 20 COG1846 MarR, Transcriptional regulators Transcription 114562921 Common - putative serine protein kinase, PrkA Sfri_1746 71 COG2766 PrkA, Putative Ser protein kinase Signal transduction mechanisms 114563102 Common - GCN5-related N-acetyltransferase Sfri_1931 49 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 114562177 Common - TatD-related deoxyribonuclease Sfri_0999 230 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 114564086 Common - cytochrome c assembly protein Sfri_2922 62 COG4137 COG4137, ABC-type uncharacterized transport system, permease component General function prediction only 114563301 Common - DNA gyrase, A subunit Sfri_2130 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 114562334 Common - FlgN family protein Sfri_1156 6 COG3418 COG3418, Flagellar biosynthesis/type III secretory pathway chaperone Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 114564565 Common - hypothetical protein Sfri_3404 23 COG2841 COG2841, Uncharacterized protein conserved in bacteria Function unknown 114563601 Common - hypothetical protein Sfri_2431 112 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 114564303 Nonpathogen - hypothetical protein Sfri_3141 1 None None None 114561662 Common - ubiquinone/menaquinone biosynthesis methyltransferases Sfri_0475 222 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 114561450 Common - aromatic amino acid transporter Sfri_0262 32 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 114563255 Nonpathogen - hypothetical protein Sfri_2084 4 None None None 114564681 Common - hypothetical protein Sfri_3529 6 None None None 114563377 Common - Methyltransferase type 11 Sfri_2206 53 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 114561847 Common - branched-chain amino acid transport system II carrier protein Sfri_0662 50 COG1114 BrnQ, Branched-chain amino acid permeases Amino acid transport and metabolism 114563965 Common - thioesterase superfamily protein Sfri_2800 11 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 114563457 Common - NADH dehydrogenase (quinone) Sfri_2286 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 114562563 Common - PHP C-terminal domain protein Sfri_1386 40 COG4464 CapC, Capsular polysaccharide biosynthesis protein Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 114561208 Common - potassium uptake protein, TrkH family protein Sfri_0020 121 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 114561859 Common - ISSod10, transposase OrfB Sfri_0674 38 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 114564097 Common - sigma E regulatory protein, MucB/RseB Sfri_2933 44 COG3026 RseB, Negative regulator of sigma E activity Signal transduction mechanisms 114563699 Common - protein of unknown function DUF58 Sfri_2531 39 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 114563748 Common - binding-protein-dependent transport systems inner membrane component Sfri_2582 214 COG4171 SapC, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 114565156 Common - multi-sensor hybrid histidine kinase Sfri_4006 224 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114562405 Nonpathogen - hypothetical protein Sfri_1227 1 None None None 114561710 Common - methyl-accepting chemotaxis sensory transducer Sfri_0524 146 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114561676 Common - FAD dependent oxidoreductase Sfri_0489 83 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 114562056 Common - cobalbumin biosynthesis enzyme Sfri_0878 128 COG2087 CobU, Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase Coenzyme metabolism 114564128 Common - methyl-accepting chemotaxis sensory transducer Sfri_2964 26 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114565066 Common - two component, sigma54 specific, transcriptional regulator, Fis family protein Sfri_3916 221 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 114564439 Common - poly(A) polymerase Sfri_3278 168 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 114562412 Common - Redoxin domain protein Sfri_1234 198 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 114563469 Common - hypothetical protein Sfri_2298 113 COG1806 COG1806, Uncharacterized protein conserved in bacteria Function unknown 114562308 Common - hypothetical protein Sfri_1130 35 None None None 114562101 Common - putative DNA-binding transcriptional regulator Sfri_0923 167 COG0583 LysR, Transcriptional regulator Transcription 114565020 Common - transcriptional regulator, XRE family protein Sfri_3870 51 COG3655 COG3655, Predicted transcriptional regulator Transcription 114564973 Common - hypothetical protein Sfri_3823 39 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 114561911 Common - 2-dehydro-3-deoxyphosphooctonate aldolase Sfri_0728 185 COG2877 KdsA, 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase Cell envelope biogenesis, outer membrane 114565159 Common - hypothetical protein Sfri_4009 14 None None None 114565188 Common - protein of unknown function DUF805 Sfri_4038 54 COG3152 COG3152, Predicted membrane protein Function unknown 114563759 Common - histone family protein DNA-binding protein Sfri_2593 211 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 114562459 Common - beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ Sfri_1281 188 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 114564139 Common - hypothetical protein Sfri_2975 1 None None None 114563084 Common - alpha/beta hydrolase fold Sfri_1913 179 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114563736 Common - predicted inner membrane peptidase Sfri_2570 189 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 114562320 Common - cytochrome bd ubiquinol oxidase, subunit I Sfri_1142 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 114562825 Common - hypothetical protein Sfri_1649 5 None None None 114562709 Common - hypothetical protein Sfri_1533 1 None None None 114562653 Common - 8-amino-7-oxononanoate synthase Sfri_1476 190 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 114561694 Common - sigma54 specific transcriptional regulator, Fis family protein Sfri_0508 174 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 114562857 Nonpathogen - hypothetical protein Sfri_1681 1 None None None 114565081 Common - CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase Sfri_3931 11 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 114563398 Common - aminopeptidase N Sfri_2227 162 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 114564250 Common rpmA 50S ribosomal protein L27 Sfri_3088 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 114561439 Common - cytochrome oxidase assembly Sfri_0251 87 COG1612 CtaA, Uncharacterized protein required for cytochrome oxidase assembly Posttranslational modification, protein turnover, chaperones 114564665 Common - diguanylate cyclase Sfri_3512 179 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 114561680 Common purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Sfri_0493 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 114563668 Nonpathogen - hypothetical protein Sfri_2499 2 None None None 114564720 Common - hypothetical protein Sfri_3568 25 COG3531 COG3531, Predicted protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 114564105 Common - Na+/H+ antiporter NhaA Sfri_2941 106 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 114564407 Common - hypothetical protein Sfri_3246 20 None None None 114561321 Common - pantothenate kinase Sfri_0133 72 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 114562488 Common - transcription factor jumonji, jmjC domain protein Sfri_1310 20 COG2850 COG2850, Uncharacterized conserved protein Function unknown 114563075 Common - PfkB domain protein Sfri_1904 153 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 114563038 Common - NlpBDapX family lipoprotein Sfri_1865 39 COG3317 NlpB, Uncharacterized lipoprotein Cell envelope biogenesis, outer membrane 114563629 Common - metal dependent phosphohydrolase Sfri_2459 112 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 114562747 Common - hypothetical protein Sfri_1571 4 None None None 114561733 Common - transcriptional regulator, LysR family protein Sfri_0547 180 COG0583 LysR, Transcriptional regulator Transcription 114565098 Common - hypothetical protein Sfri_3948 13 None None None 114563236 Common - MaoC domain protein dehydratase Sfri_2065 70 COG2030 MaoC, Acyl dehydratase Lipid metabolism 114563004 Common - periplasmic sensor hybrid histidine kinase Sfri_1829 221 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 114561928 Common - DSBA oxidoreductase Sfri_0746 82 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 114565024 Common - Oligopeptidase A Sfri_3874 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 114561821 Common - extracellular solute-binding protein, family 1 Sfri_0636 102 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 114564995 Common - Twin-arginine translocation pathway signal Sfri_3845 24 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 114561250 Common - hypothetical protein Sfri_0062 23 None None None 114564922 Common - transposase IS116/IS110/IS902 family protein Sfri_3770 91 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 114563405 Common - Mammalian cell entry related domain protein Sfri_2234 56 COG3008 PqiB, Paraquat-inducible protein B General function prediction only 114564965 Common - glycerol kinase Sfri_3815 178 COG0554 GlpK, Glycerol kinase Energy production and conversion 114564759 Common - diguanylate cyclase/phosphodiesterase with GAF sensor Sfri_3607 165 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 114562964 Common - glucose/galactose transporter Sfri_1789 54 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 114561548 Common - Na+/Ca+ antiporter, CaCA family protein Sfri_0360 131 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 114563422 Common aat leucyl/phenylalanyl-tRNA--protein transferase Sfri_2251 134 COG2360 Aat, Leu/Phe-tRNA-protein transferase Posttranslational modification, protein turnover, chaperones 114564347 Common cysN sulfate adenylyltransferase subunit 1 Sfri_3186 249 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 114563967 Common - Redoxin domain protein Sfri_2802 128 COG2077 Tpx, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 114564153 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Sfri_2989 49 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 114562948 Common - protein of unknown function DUF808 Sfri_1773 61 COG2354 COG2354, Uncharacterized protein conserved in bacteria Function unknown 114564924 Common - predicted hydrolase Sfri_3772 195 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 114565116 Common - 2,3-diketo-5-methylthio-1-phosphopentane phosphatase Sfri_3966 31 COG4229 COG4229, Predicted enolase-phosphatase Energy production and conversion 114562021 Common - Pseudouridine synthase, Rsu Sfri_0843 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 114564526 Common - BolA family protein Sfri_3365 90 COG5007 COG5007, Predicted transcriptional regulator, BolA superfamily Transcription 114564656 Common - TonB-dependent receptor Sfri_3503 35 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 114562867 Common - hypothetical protein Sfri_1691 1 None None None 114563112 Common - hypothetical protein Sfri_1941 7 None None None 114563630 Common - hypothetical protein Sfri_2460 10 None None None 114561756 Common - Na+/H+ antiporter NhaC Sfri_0570 73 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 114563273 Common - hypothetical protein Sfri_2102 65 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 114562702 Common - TonB-dependent receptor Sfri_1526 110 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 114563953 Common - exodeoxyribonuclease VII, small subunit Sfri_2788 125 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 114564052 Common - peptidylprolyl isomerase, FKBP-type Sfri_2888 124 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 114564942 Common - ISSod10, transposase OrfB Sfri_3792 36 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 114564579 Common - type III restriction enzyme, res subunit Sfri_3418 49 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 114562990 Common - heat shock protein DnaJ domain protein Sfri_1815 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 114563442 Common - protein of unknown function DUF1538 Sfri_2271 23 None None None 114561838 Common - hypothetical protein Sfri_0653 1 None None None 114562628 Common - phosphoribosylglycinamide formyltransferase Sfri_1451 223 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 114564426 Common - hypothetical protein Sfri_3265 10 COG3789 COG3789, Uncharacterized protein conserved in bacteria Function unknown 114565181 Common - membrane protein-like protein Sfri_4031 13 COG3205 COG3205, Predicted membrane protein Function unknown 114561624 Common - HemY domain protein Sfri_0437 41 COG3071 HemY, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 114564340 Nonpathogen - Ankyrin Sfri_3179 1 None None None 114561962 Common - KAP P-loop domain protein Sfri_0781 14 None None None 114564381 Common - hypothetical protein Sfri_3220 2 None None None 114562533 Common - hypothetical protein Sfri_1355 19 None None None 114561352 Common rplR 50S ribosomal protein L18 Sfri_0164 208 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 114562028 Nonpathogen - hypothetical protein Sfri_0850 2 None None None 114564388 Common - diguanylate cyclase Sfri_3227 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114563804 Common - cytochrome C family protein Sfri_2638 39 None None None 114561239 Common - formate dehydrogenase, subunit FdhD Sfri_0051 133 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 114563393 Common - hypothetical protein Sfri_2222 111 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 114564616 Common - Group II intron, maturase-specific domain protein Sfri_3460 41 None None None 114564708 Common - cytochrome c, putative Sfri_3556 21 None None None 114564840 Common - two component, sigma54 specific, transcriptional regulator, Fis family protein Sfri_3688 187 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 114563187 Common - cytochrome oxidase maturation protein, cbb3-type Sfri_2016 15 COG3197 FixS, Uncharacterized protein, possibly involved in nitrogen fixation Inorganic ion transport and metabolism 114563738 Common - short chain dehydrogenase Sfri_2572 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 114564820 Common - galactokinase Sfri_3668 85 COG0153 GalK, Galactokinase Carbohydrate transport and metabolism 114561315 Common - RNP-1 like RNA-binding protein Sfri_0127 66 COG0724 COG0724, RNA-binding proteins (RRM domain) General function prediction only 114562770 Common - glutaredoxin Sfri_1594 20 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 114563824 Common - hypothetical protein Sfri_2658 6 None None None 114564018 Common - hypothetical protein Sfri_2854 16 None None None 114564464 Common - ClpXP protease specificity-enhancing factor Sfri_3303 64 COG2969 SspB, Stringent starvation protein B General function prediction only 114561639 Common - UvrD/REP helicase Sfri_0452 209 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 114562917 Common nhaB sodium/proton antiporter Sfri_1742 34 COG3067 NhaB, Na+/H+ antiporter Inorganic ion transport and metabolism 114563581 Common - hypothetical protein Sfri_2411 15 COG3219 COG3219, Uncharacterized protein conserved in bacteria Function unknown 114561883 Common - hypothetical protein Sfri_0700 161 COG1576 COG1576, Uncharacterized conserved protein Function unknown 114562558 Common - polysaccharide biosynthesis protein Sfri_1380 61 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 114564452 Common - Tetratricopeptide TPR_2 repeat protein Sfri_3291 71 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 114561893 Common - CBS domain containing protein Sfri_0710 221 COG4535 CorC, Putative Mg2+ and Co2+ transporter CorC Inorganic ion transport and metabolism 114563360 Common - gonadoliberin III-related protein Sfri_2189 18 None None None 114561436 Common - polysaccharide deacetylase Sfri_0248 90 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 114561804 Common - hypothetical protein Sfri_0619 22 COG3112 COG3112, Uncharacterized protein conserved in bacteria Function unknown 114564572 Common - Elongator protein 3/MiaB/NifB Sfri_3411 33 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 114564822 Common - hypothetical protein Sfri_3670 3 COG4711 COG4711, Predicted membrane protein Function unknown 114564754 Common - RNA-metabolising metallo-beta-lactamase Sfri_3602 126 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 114564934 Common - methylation site containing protein Sfri_3782 17 COG4969 PilA, Tfp pilus assembly protein, major pilin PilA Cell motility and secretion / Intracellular trafficking and secretion 114562221 Common - recombination and repair protein Sfri_1043 200 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 114563921 Common - Patatin Sfri_2756 45 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 114562548 Nonpathogen - hypothetical protein Sfri_1370 1 None None None 114562228 Common mazG nucleoside triphosphate pyrophosphohydrolase Sfri_1050 156 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 114564008 Common - NusG antitermination factor Sfri_2844 51 COG0250 NusG, Transcription antiterminator Transcription 114561723 Common - peptidase M50 Sfri_0537 16 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 114563605 Common - carbon starvation protein CstA Sfri_2435 109 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 114563159 Common - Lytic transglycosylase, catalytic Sfri_1988 105 COG1388 LytE, FOG: LysM repeat Cell envelope biogenesis, outer membrane 114561332 Common - 30S ribosomal protein S7 Sfri_0144 247 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 114564272 Common - hypothetical protein Sfri_3110 21 None None None 114562673 Common - 3-oxoacyl-(acyl carrier protein) synthase III Sfri_1497 223 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 114563622 Common - exonuclease subunit SbcD Sfri_2452 108 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 114563636 Common - diguanylate cyclase Sfri_2466 216 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 114564257 Common - thiol:disulfide interchange protein, putative Sfri_3095 49 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 114563761 Common clpX ATP-dependent protease ATP-binding subunit Sfri_2595 236 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 114562003 Nonpathogen - hypothetical protein Sfri_0823 2 None None None 114563696 Common - protein of unknown function DUF195 Sfri_2528 137 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 114564539 Common - sigma 54 modulation protein/ribosomal protein S30EA Sfri_3378 126 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 114563216 Common - enoyl-CoA hydratase Sfri_2045 138 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 114563628 Common - NAD-dependent epimerase/dehydratase Sfri_2458 68 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 114564597 Common - transcriptional regulator, LysR family protein Sfri_3440 183 COG0583 LysR, Transcriptional regulator Transcription 114564544 Common - conserved hypothetical transposase Sfri_3383 1 None None None 114561796 Common - TonB-dependent receptor Sfri_0611 99 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 114563823 Common - ribosome modulation factor Sfri_2657 21 COG3130 Rmf, Ribosome modulation factor Translation, ribosomal structure and biogenesis 114563311 Nonpathogen - Calcium-binding EF-hand-containing protein Sfri_2140 3 None None None 114563585 Common - transcriptional regulators, TraR/DksA family protein Sfri_2415 5 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 114564671 Common - hypothetical protein Sfri_3518 1 None None None 114561411 Common - Cytochrome-c oxidase Sfri_0223 166 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 114564113 Common - Hpt protein Sfri_2949 22 COG2198 ArcB, FOG: HPt domain Signal transduction mechanisms 114564714 Common - Integrase, catalytic region Sfri_3562 134 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 114562035 Nonpathogen - hypothetical protein Sfri_0857 6 None None None 114563903 Nonpathogen - hypothetical protein Sfri_2738 4 COG1563 COG1563, Predicted subunit of the Multisubunit Na+/H+ antiporter Inorganic ion transport and metabolism 114564585 Common - Carboxylesterase Sfri_3426 109 COG0627 COG0627, Predicted esterase General function prediction only 114562493 Common - sugar (Glycoside-Pentoside-Hexuronide) transporter Sfri_1315 87 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 114562780 Common - peptidase M28 Sfri_1604 50 COG2234 Iap, Predicted aminopeptidases General function prediction only 114564549 Common - hypothetical protein Sfri_3388 1 None None None 114562889 Common - imidazole glycerol phosphate synthase subunit HisF Sfri_1714 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 114563882 Common - TRAP dicarboxylate transporter, DctM subunit Sfri_2717 135 COG1593 DctQ, TRAP-type C4-dicarboxylate transport system, large permease component Carbohydrate transport and metabolism 114561293 Common - general secretion pathway protein D Sfri_0105 141 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 114564356 Common pntB pyridine nucleotide transhydrogenase Sfri_3195 123 COG1282 PntB, NAD/NADP transhydrogenase beta subunit Energy production and conversion 114562203 Common - thioesterase superfamily protein Sfri_1025 65 COG0824 FcbC, Predicted thioesterase General function prediction only 114564279 Common - hypothetical protein Sfri_3117 7 COG3531 COG3531, Predicted protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 114564630 Common - Resolvase, N-terminal domain protein Sfri_3474 144 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 114564819 Common - sodium/hydrogen exchanger Sfri_3667 187 COG4651 RosB, Kef-type K+ transport system, predicted NAD-binding component Inorganic ion transport and metabolism 114561275 Common - molybdate ABC transporter, inner membrane subunit Sfri_0087 226 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 114563384 Common - transcriptional regulator, LysR family protein Sfri_2213 116 COG0583 LysR, Transcriptional regulator Transcription 114562775 Common - protein of unknown function DUF1289 Sfri_1599 16 COG3313 COG3313, Predicted Fe-S protein General function prediction only 114561703 Common - hypothetical protein Sfri_0517 4 None None None 114563496 Common - transcriptional regulator, LysR family protein Sfri_2325 160 COG0583 LysR, Transcriptional regulator Transcription 114563391 Common - dihydroorotate dehydrogenase 2 Sfri_2220 234 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 114562750 Common - hypothetical protein Sfri_1574 15 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 114564435 Common - aminopeptidase B Sfri_3274 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 114561601 Common - branched-chain amino acid aminotransferase Sfri_0414 192 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 114562794 Common - hypothetical protein Sfri_1618 2 None None None 114563553 Common - acriflavin resistance protein Sfri_2383 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 114564718 Common - TRAP transporter solute receptor, TAXI family protein Sfri_3566 88 COG2358 Imp, TRAP-type uncharacterized transport system, periplasmic component General function prediction only 114562444 Common - metal dependent phosphohydrolase Sfri_1266 126 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 114564882 Common - outer membrane efflux protein Sfri_3730 81 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 114562262 Common - sigma 54 modulation protein/ribosomal protein S30EA Sfri_1084 41 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 114563023 Common - hypothetical protein Sfri_1850 7 None None None 114562895 Common hisG ATP phosphoribosyltransferase Sfri_1720 211 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 114561447 Common - hypothetical protein Sfri_0259 20 COG5404 SulA, SOS-response cell division inhibitor, blocks FtsZ ring formation Cell division and chromosome partitioning 114562799 Common - two component transcriptional regulator, winged helix family protein Sfri_1623 213 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114563472 Common - protein of unknown function DUF541 Sfri_2301 28 COG2859 COG2859, Uncharacterized protein conserved in bacteria Function unknown 114562285 Common - hypothetical protein Sfri_1107 75 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 114562602 Common - tryptophan synthase subunit beta Sfri_1425 224 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 114563570 Common - hypothetical protein Sfri_2400 7 None None None 114564230 Nonpathogen - Cupin 2, conserved barrel domain protein Sfri_3067 6 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 114564375 Common - hypothetical protein Sfri_3214 8 None None None 114562798 Common - periplasmic sensor signal transduction histidine kinase Sfri_1622 212 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 114562105 Common - RDD domain containing protein Sfri_0927 19 COG1714 COG1714, Predicted membrane protein/domain Function unknown 114561841 Common - sensory box protein, putative Sfri_0656 2 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 114564848 Common - Feruloyl esterase Sfri_3696 21 None None None 114562716 Common - adenylate kinases Sfri_1540 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 114561959 Common - hypothetical protein Sfri_0778 38 COG4338 COG4338, Uncharacterized protein conserved in bacteria Function unknown 114562189 Common - type IV pilus assembly PilZ Sfri_1011 20 None None None 114562787 Common - sugar-binding protein, putative Sfri_1611 42 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 114564491 Common - protein of unknown function DUF1249 Sfri_3330 24 COG3151 COG3151, Uncharacterized protein conserved in bacteria Function unknown 114564915 Common - Sporulation domain protein Sfri_3763 37 COG3087 FtsN, Cell division protein Cell division and chromosome partitioning 114561543 Common - hypothetical protein Sfri_0355 12 None None None 114562121 Common - Mg2 transporter protein, CorA family protein Sfri_0943 170 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 114564205 Common - band 7 protein Sfri_3042 137 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 114565146 Common - hypothetical protein Sfri_3996 1 None None None 114563193 Common - Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase Sfri_2022 31 COG2992 Bax, Uncharacterized FlgJ-related protein General function prediction only 114562855 Common - putative RecA/RadA recombinase Sfri_1679 9 COG5471 COG5471, Uncharacterized conserved protein Function unknown 114564637 Common - hypothetical protein Sfri_3482 7 None None None 114565005 Common - HPP family protein Sfri_3855 73 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 114564135 Common - tyrosyl-tRNA synthetase Sfri_2971 240 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 114562252 Common - hypothetical protein Sfri_1074 38 COG4764 COG4764, Uncharacterized protein conserved in bacteria Function unknown 114564170 Common - binding-protein-dependent transport systems inner membrane component Sfri_3007 186 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 114564229 Common - hypothetical protein Sfri_3066 3 None None None 114564784 Common - response regulator receiver protein Sfri_3632 1 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 114564290 Common - anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family protein Sfri_3128 181 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 114563051 Common - hypothetical protein Sfri_1879 5 None None None 114563012 Common - thioesterase superfamily protein Sfri_1838 17 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 114561550 Common - putative endoribonuclease L-PSP Sfri_0362 185 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 114562952 Common - alpha-glucosidase Sfri_1777 18 None None None 114561746 Common - transcriptional regulator, LuxR family protein Sfri_0560 149 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 114563989 Common - undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase Sfri_2825 210 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 114563662 Common - protein of unknown function DUF1414 Sfri_2492 21 COG3082 COG3082, Uncharacterized protein conserved in bacteria Function unknown 114565217 Nonpathogen - hypothetical protein Sfri_4067 1 None None None 114565173 Common - protein of unknown function DUF610, YibQ Sfri_4023 65 COG2861 COG2861, Uncharacterized protein conserved in bacteria Function unknown 114561988 Common - hypothetical protein Sfri_0808 9 None None None 114564553 Common - deoxyUTP pyrophosphatase Sfri_3392 2 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 114564895 Common - methylation site containing protein Sfri_3743 5 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 114561748 Common - hypothetical protein Sfri_0562 9 None None None 114562959 Common - alpha amylase, catalytic region Sfri_1784 67 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 114563775 Nonpathogen - hypothetical protein Sfri_2609 1 None None None 114564245 Common - hypothetical protein Sfri_3083 4 None None None 114563868 Common - S-adenosylmethionine--tRNA-ribosyltransferase-isomerase Sfri_2703 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 114564523 Common - protease Do Sfri_3362 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 114564793 Nonpathogen - hypothetical protein Sfri_3641 2 None None None 114562740 Common - heat shock protein Hsp20 Sfri_1564 64 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 114564281 Common - hypothetical protein Sfri_3119 30 None None None 114564863 Common - major facilitator superfamily MFS_1 Sfri_3711 185 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 114565187 Common - PUA domain containing protein Sfri_4037 142 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 114561863 Common - fumarate reductase Sfri_0679 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 114561784 Nonpathogen - hypothetical protein Sfri_0599 1 None None None 114561266 Common - MOSC domain containing protein Sfri_0078 77 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 114561474 Common - protein of unknown function DUF1332 Sfri_0286 31 COG4103 COG4103, Uncharacterized protein conserved in bacteria Function unknown 114563946 Common - protein of unknown function DUF423 Sfri_2781 73 COG2363 COG2363, Uncharacterized small membrane protein Function unknown 114562083 Common - putative lipoprotein Sfri_0905 8 None None None 114564725 Nonpathogen - hypothetical protein Sfri_3573 1 None None None 114562297 Common - outer membrane protein assembly complex subunit YfgL Sfri_1119 125 COG1520 COG1520, FOG: WD40-like repeat Function unknown 114562485 Common - Beta-glucosidase Sfri_1307 96 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 114564704 Common - transcriptional repressor protein MetJ Sfri_3552 23 COG3060 MetJ, Transcriptional regulator of met regulon Transcription / Amino acid transport and metabolism 114563919 Common - GAF sensor signal transduction histidine kinase Sfri_2754 207 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 114564404 Common - hypothetical protein Sfri_3243 39 COG3417 FlgN, Collagen-binding surface adhesin SpaP (antigen I/II family) General function prediction only 114565164 Common - transposase IS3/IS911 family protein Sfri_4014 50 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 114563483 Common - peptidylprolyl isomerase, FKBP-type Sfri_2312 121 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 114562609 Common - chromosome segregation and condensation protein ScpA Sfri_1432 136 COG1354 COG1354, Uncharacterized conserved protein Function unknown 114561967 Common - pseudouridine synthase Sfri_0787 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 114564213 Common - F0F1 ATP synthase subunit epsilon Sfri_3050 19 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 114564451 Common - Phosphoribulokinase Sfri_3290 51 COG3954 PrkB, Phosphoribulokinase Energy production and conversion 114561997 Common - alpha amylase, catalytic region Sfri_0817 158 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 114562195 Common - Ig-like, group 2 Sfri_1017 19 None None None 114562134 Common - protein of unknown function DUF539 Sfri_0956 8 COG2991 COG2991, Uncharacterized protein conserved in bacteria Function unknown 114564625 Common - transposase Tn3 family protein Sfri_3469 48 COG4644 COG4644, Transposase and inactivated derivatives, TnpA family DNA replication, recombination, and repair 114561193 Common - metal dependent phosphohydrolase Sfri_0005 39 COG3434 COG3434, Predicted signal transduction protein containing EAL and modified HD-GYP domains Signal transduction mechanisms 114565039 Nonpathogen - hypothetical protein Sfri_3889 3 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 114561463 Common - signal recognition particle-docking protein FtsY Sfri_0275 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 114562872 Common - protein of unknown function DUF480 Sfri_1696 41 COG3132 COG3132, Uncharacterized protein conserved in bacteria Function unknown 114562060 Common - transcriptional regulator, HxlR family protein Sfri_0882 146 COG1733 COG1733, Predicted transcriptional regulators Transcription 114563842 Common fadI 3-ketoacyl-CoA thiolase Sfri_2677 177 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 114564068 Common - threonine synthase Sfri_2904 158 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 114564164 Common - pseudouridine synthase Sfri_3001 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 114565195 Common - F0F1 ATP synthase subunit beta Sfri_4045 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 114562046 Common - hypothetical protein Sfri_0868 12 None None None 114564183 Nonpathogen - hypothetical protein Sfri_3020 5 None None None 114563264 Common - amidohydrolase Sfri_2093 90 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 114561874 Common - ribosomal-protein-alanine acetyltransferase Sfri_0691 182 COG0456 RimI, Acetyltransferases General function prediction only 114561668 Common - anti-RNA polymerase sigma 70 factor Sfri_0481 24 COG3160 Rsd, Regulator of sigma D Transcription 114564877 Common - transcriptional regulator, LysR family protein Sfri_3725 159 COG0583 LysR, Transcriptional regulator Transcription 114564488 Common - DNA topoisomerase IV subunit B Sfri_3327 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 114561773 Common - protein of unknown function DUF134 Sfri_0587 42 COG1342 COG1342, Predicted DNA-binding proteins General function prediction only 114563283 Common - hydrogenase expression/formation protein HypE Sfri_2112 127 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 114562726 Common - 3-oxoacyl-(acyl carrier protein) synthase III Sfri_1550 207 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 114563831 Common - ATP-NAD/AcoX kinase Sfri_2665 26 COG3199 COG3199, Uncharacterized conserved protein Function unknown 114563594 Common - cysteine desulfurase IscS Sfri_2424 240 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 114561344 Common - 50S ribosomal protein L29 Sfri_0156 153 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 114563705 Nonpathogen - hypothetical protein Sfri_2538 1 None None None 114563859 Common - YaeQ family protein Sfri_2694 52 COG4681 COG4681, Uncharacterized protein conserved in bacteria Function unknown 114562516 Common - acetyl-CoA acetyltransferases Sfri_1338 186 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 114562393 Common - methyl-accepting chemotaxis sensory transducer Sfri_1215 144 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114563932 Common - PAS/PAC sensor signal transduction histidine kinase Sfri_2767 222 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 114561359 Common - 30S ribosomal protein S11 Sfri_0171 248 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 114565208 Common - Carboxylesterase Sfri_4058 107 COG0627 COG0627, Predicted esterase General function prediction only 114562438 Common - hypothetical protein Sfri_1260 10 None None None 114563230 Common - molybdopterin oxidoreductase Sfri_2059 181 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 114561621 Common - type I secretion membrane fusion protein, HlyD family protein Sfri_0434 116 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 114563938 Common - TPR repeat-containing protein Sfri_2773 34 None None None 114564535 Common - protein of unknown function DUF1239 Sfri_3374 36 COG3117 COG3117, Uncharacterized protein conserved in bacteria Function unknown 114561508 Common - nitrogen metabolism transcriptional regulator, NtrC, Fis Family Sfri_0320 218 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 114564442 Common - pantoate--beta-alanine ligase Sfri_3281 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 114563813 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Sfri_2647 205 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 114562159 Common - protein of unknown function UPF0044 Sfri_0981 96 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 114561626 Common - Uroporphyrinogen III synthase HEM4 Sfri_0439 71 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 114563603 Common - signal transduction histidine kinase, LytS Sfri_2433 105 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 114563068 Common - aspartate racemase Sfri_1897 81 COG1794 RacX, Aspartate racemase Cell envelope biogenesis, outer membrane 114561766 Common - chromate transporter, chromate ion transporter (CHR) family protein Sfri_0580 105 COG2059 ChrA, Chromate transport protein ChrA Inorganic ion transport and metabolism 114561425 Common - diacylglycerol kinase Sfri_0237 66 COG0818 DgkA, Diacylglycerol kinase Cell envelope biogenesis, outer membrane 114563138 Common - hypothetical protein Sfri_1967 3 None None None 114564764 Common - hypothetical protein Sfri_3612 7 None None None 114564603 Nonpathogen - putative transcriptional regulator Sfri_3447 7 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 114562478 Common - SNF2-related protein Sfri_1300 134 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 114561532 Common - hypothetical protein Sfri_0344 18 None None None 114564519 Common - hypothetical protein Sfri_3358 15 COG3242 COG3242, Uncharacterized protein conserved in bacteria Function unknown 114562721 Common - diguanylate cyclase Sfri_1545 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114561814 Common - hypothetical protein Sfri_0629 1 None None None 114563143 Common - copper resistance D domain protein Sfri_1972 8 COG1276 PcoD, Putative copper export protein Inorganic ion transport and metabolism 114564950 Common - cell division protein FtsZ Sfri_3800 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 114563061 Common - Pyruvate kinase Sfri_1890 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 114563095 Common - ATP-dependent DNA helicase, RecQ family protein Sfri_1924 236 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 114562148 Common - chaperone protein DnaJ Sfri_0970 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 114561592 Common - hypothetical protein Sfri_0405 1 None None None 114561701 Common - Pseudouridylate synthase Sfri_0515 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 114561349 Common rpsN 30S ribosomal protein S14 Sfri_0161 205 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 114562247 Common - sodium:dicarboxylate symporter Sfri_1069 163 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 114562644 Common - type III restriction enzyme, res subunit Sfri_1467 142 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 114563721 Common - NapD family protein Sfri_2554 24 COG3062 NapD, Uncharacterized protein involved in formation of periplasmic nitrate reductase Inorganic ion transport and metabolism 114562835 Nonpathogen - hypothetical protein Sfri_1659 1 None None None 114564092 Common era GTP-binding protein Era Sfri_2928 233 COG1159 Era, GTPase General function prediction only 114562523 Common - hypothetical protein Sfri_1345 1 None None None 114564983 Common - peptidase S9, prolyl oligopeptidase active site domain protein Sfri_3833 124 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 114564664 Common - CheC, inhibitor of MCP methylation Sfri_3511 204 COG1776 CheC, Chemotaxis protein CheC, inhibitor of MCP methylation Cell motility and secretion / Signal transduction mechanisms 114561245 Common - Twin-arginine translocation pathway signal Sfri_0057 191 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 114562933 Common - hypothetical protein Sfri_1758 1 None None None 114564500 Common - transposase Sfri_3339 9 None None None 114562909 Common - ribonuclease D Sfri_1734 115 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 114561277 Common - hypothetical protein Sfri_0089 1 None None None 114562837 Nonpathogen - hypothetical protein Sfri_1661 1 None None None 114562638 Common - TolA family protein Sfri_1461 19 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 114563452 Common - cation antiporter Sfri_2281 51 COG1863 MnhE, Multisubunit Na+/H+ antiporter, MnhE subunit Inorganic ion transport and metabolism 114564410 Common - Sel1 domain protein repeat-containing protein Sfri_3249 68 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 114563343 Common - Na(+)-translocating NADH-quinone reductase subunit E Sfri_2172 76 COG4657 RnfA, Predicted NADH:ubiquinone oxidoreductase, subunit RnfA Energy production and conversion 114563303 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Sfri_2132 143 COG0546 Gph, Predicted phosphatases General function prediction only 114562180 Common - deoxyribose-phosphate aldolase Sfri_1002 138 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 114563857 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Sfri_2692 95 COG4935 COG4935, Regulatory P domain of the subtilisin-like proprotein convertases and other proteases Posttranslational modification, protein turnover, chaperones 114563554 Common - beta-lactamase domain protein Sfri_2384 77 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 114562471 Common - potassium efflux system protein Sfri_1293 214 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 114564185 Common - beta alanine--pyruvate transaminase Sfri_3022 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 114563960 Common - cobalamin synthesis protein, P47K Sfri_2795 127 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 114561584 Common - hypothetical protein Sfri_0396 73 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 114562017 Common - hypothetical protein Sfri_0839 1 COG2944 COG2944, Predicted transcriptional regulator Transcription 114562713 Common - recombination protein RecR Sfri_1537 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 114563281 Common - hydrogenase assembly chaperone hypC/hupF Sfri_2110 87 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 114563874 Common - dual specificity protein phosphatase Sfri_2709 1 COG2453 CDC14, Predicted protein-tyrosine phosphatase Signal transduction mechanisms 114561603 Common - phospholipid/glycerol acyltransferase Sfri_0416 30 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 114562870 Common - ABC transporter related Sfri_1694 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 114564469 Common - HflC protein Sfri_3308 212 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 114561272 Common - molybdopterin converting factor, subunit 1 Sfri_0084 43 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 114563225 Common - IstB domain protein ATP-binding protein Sfri_2054 105 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 114563520 Common - hypothetical protein Sfri_2349 2 None None None 114565033 Nonpathogen - hypothetical protein Sfri_3883 1 None None None 114561786 Nonpathogen - hypothetical protein Sfri_0601 2 None None None 114563860 Common - siroheme synthase Sfri_2695 149 COG1648 CysG, Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) Coenzyme metabolism 114562782 Common - AMP-dependent synthetase and ligase Sfri_1606 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 114564448 Common - hypothetical protein Sfri_3287 1 None None None 114563579 Common - protein of unknown function DUF454 Sfri_2409 64 COG2832 COG2832, Uncharacterized protein conserved in bacteria Function unknown 114562818 Nonpathogen - hypothetical protein Sfri_1642 1 None None None 114564509 Common rplI 50S ribosomal protein L9 Sfri_3348 174 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 114563347 Common - electron transport complex, RnfABCDGE type, G subunit Sfri_2176 56 COG4659 RnfG, Predicted NADH:ubiquinone oxidoreductase, subunit RnfG Energy production and conversion 114564805 Common - Methyltransferase type 12 Sfri_3653 42 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 114565054 Common - malate synthase Sfri_3904 52 None None None 114564741 Common - hypothetical protein Sfri_3589 1 None None None 114561758 Common - Pseudouridine synthase, Rsu Sfri_0572 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 114565119 Common - hypothetical protein Sfri_3969 17 COG2388 COG2388, Predicted acetyltransferase General function prediction only 114562581 Common - transcriptional regulator, LysR family protein Sfri_1404 153 COG0583 LysR, Transcriptional regulator Transcription 114565017 Common - hypothetical protein Sfri_3867 21 COG0824 FcbC, Predicted thioesterase General function prediction only 114565138 Common - TonB-dependent receptor Sfri_3988 52 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 114565133 Common - methylation site containing protein Sfri_3983 7 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 114562517 Common - methylmalonate-semialdehyde dehydrogenase Sfri_1339 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 114563798 Common - primosomal replication protein N'', putative Sfri_2632 6 None None None 114561219 Common - globin Sfri_0031 66 COG2346 COG2346, Truncated hemoglobins General function prediction only 114561632 Common dapF diaminopimelate epimerase Sfri_0445 202 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 114562767 Common - MATE efflux family protein Sfri_1591 138 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 114565096 Common - hypothetical protein Sfri_3946 20 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 114562446 Common - PII uridylyl-transferase Sfri_1268 123 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 114564154 Common - dihydroneopterin aldolase Sfri_2990 100 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 114564318 Nonpathogen - hypothetical protein Sfri_3157 1 None None None 114563351 Common ruvB Holliday junction DNA helicase B Sfri_2180 237 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 114563845 Common - hypothetical protein Sfri_2680 8 None None None 114564889 Common - rod shape-determining protein MreC Sfri_3737 123 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 114561524 Common - methyl-accepting chemotaxis sensory transducer Sfri_0336 131 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114561969 Common - sulfotransferase Sfri_0789 17 None None None 114562666 Common - ribonuclease, Rne/Rng family protein Sfri_1490 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 114563664 Common - hypothetical protein Sfri_2494 2 None None None 114563684 Common - permease Sfri_2516 107 COG0701 COG0701, Predicted permeases General function prediction only 114563367 Common thiH thiamine biosynthesis protein ThiH Sfri_2196 55 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 114562069 Common - SEC-C motif domain protein Sfri_0891 17 COG3318 COG3318, Predicted metal-binding protein related to the C-terminal domain of SecA General function prediction only 114562938 Common - alpha/beta hydrolase fold Sfri_1763 166 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 114561771 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Sfri_0585 244 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 114562661 Common - DNA ligase Sfri_1484 33 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 114565120 Common - thioesterase superfamily protein Sfri_3970 36 COG0824 FcbC, Predicted thioesterase General function prediction only 114564511 Common - primosomal replication protein N Sfri_3350 22 COG2965 PriB, Primosomal replication protein N DNA replication, recombination, and repair 114564226 Common - hypothetical protein Sfri_3063 4 None None None 114561848 Common - tyrosine recombinase XerD Sfri_0663 229 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 114563502 Common - methyl-accepting chemotaxis sensory transducer Sfri_2331 146 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114563254 Common - hypothetical protein Sfri_2083 11 None None None 114562378 Common - response regulator receiver protein Sfri_1200 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 114562423 Common - 4'-phosphopantetheinyl transferase Sfri_1245 37 COG2091 Sfp, Phosphopantetheinyl transferase Coenzyme metabolism 114562592 Common - Twin-arginine translocation pathway signal Sfri_1415 106 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 114563791 Common - MotA/TolQ/ExbB proton channel Sfri_2625 137 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 114563184 Common - cytochrome c oxidase, cbb3-type, subunit III Sfri_2013 81 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 114563147 Common - sigma54 specific transcriptional regulator, Fis family protein Sfri_1976 171 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 114562079 Common - two component, sigma54 specific, transcriptional regulator, Fis family protein Sfri_0901 181 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 114565110 Common - Integrase, catalytic region Sfri_3960 121 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 114561304 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Sfri_0116 33 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 114564144 Common - glutamate-1-semialdehyde-2,1-aminomutase Sfri_2980 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 114562841 Common - putative adenylyl cyclase CyaB Sfri_1665 18 COG1437 CyaB, Adenylate cyclase, class 2 (thermophilic) Nucleotide transport and metabolism 114561898 Common - Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family protein Sfri_0715 117 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 114564361 Common - bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase Sfri_3200 187 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 114564368 Common - Na(+)-translocating NADH-quinone reductase subunit E Sfri_3207 76 COG2209 NqrE, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE Energy production and conversion 114563838 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Sfri_2672 191 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114564606 Common - transposase IS3/IS911 family protein Sfri_3450 60 None None None 114562789 Common - Glutathione S-transferase, N-terminal domain protein Sfri_1613 50 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 114564049 Common - Prepilin-type cleavage/methylation-like protein Sfri_2885 16 COG4966 PilW, Tfp pilus assembly protein PilW Cell motility and secretion / Intracellular trafficking and secretion 114561561 Common - Pilus assembly protein, PilQ Sfri_0373 37 COG3168 PilP, Tfp pilus assembly protein PilP Cell motility and secretion / Intracellular trafficking and secretion 114565010 Common - Lytic transglycosylase, catalytic Sfri_3860 166 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 114562553 Common - glycosyl transferase, WecB/TagA/CpsF family protein Sfri_1375 100 COG1922 WecG, Teichoic acid biosynthesis proteins Cell envelope biogenesis, outer membrane 114562803 Common - acetolactate synthase, small subunit Sfri_1627 193 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 114563814 Common uvrC excinuclease ABC subunit C Sfri_2648 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 114564419 Common - hypothetical protein Sfri_3258 6 None None None 114561224 Common - diguanylate cyclase Sfri_0036 173 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 114561641 Common - putative TIM-barrel protein, nifR3 family protein Sfri_0454 211 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 114562371 Common - flagellar biosynthetic protein FliQ Sfri_1193 96 COG1987 FliQ, Flagellar biosynthesis pathway, component FliQ Cell motility and secretion / Intracellular trafficking and secretion 114561992 Common - protein of unknown function DUF1111 Sfri_0812 50 COG3488 COG3488, Predicted thiol oxidoreductase Energy production and conversion 114564399 Common - peptidylprolyl isomerase, FKBP-type Sfri_3238 137 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 114564555 Nonpathogen - hypothetical protein Sfri_3394 1 None None None 114561373 Common - Redoxin domain protein Sfri_0185 135 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 114562686 Common - nitrite reductase (NAD(P)H), small subunit Sfri_1510 45 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 114561358 Common rpsM 30S ribosomal protein S13 Sfri_0170 239 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 114561916 Common - hypothetical protein Sfri_0733 4 None None None 114562570 Common - aspartate-semialdehyde dehydrogenase Sfri_1393 236 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 114562407 Nonpathogen - Tetratricopeptide TPR_2 repeat protein Sfri_1229 11 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 114562985 Common - DNA polymerase III subunit epsilon Sfri_1810 79 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 114563923 Common - glucose-1-phosphate thymidylyltransferase Sfri_2758 230 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 114562974 Common - seryl-tRNA synthetase Sfri_1799 243 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 114561259 Common - TPR repeat-containing protein Sfri_0071 33 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 114562355 Common fliS flagellar protein FliS Sfri_1177 92 COG1516 FliS, Flagellin-specific chaperone FliS Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 114562242 Common - carbon storage regulator, CsrA Sfri_1064 81 COG1551 CsrA, Carbon storage regulator (could also regulate swarming and quorum sensing) Signal transduction mechanisms 114564167 Common - succinic semialdehyde dehydrogenase Sfri_3004 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 114563447 Nonpathogen - hypothetical protein Sfri_2276 3 COG1359 COG1359, Uncharacterized conserved protein Function unknown 114563850 Common - hypothetical protein Sfri_2685 8 None None None 114563081 Common - flavodoxin FldA Sfri_1910 72 COG0716 FldA, Flavodoxins Energy production and conversion 114563267 Common - protein of unknown function DUF302 Sfri_2096 33 COG3439 COG3439, Uncharacterized conserved protein Function unknown 114561383 Common - argininosuccinate lyase Sfri_0195 235 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 114561656 Common - hypothetical protein Sfri_0469 4 None None None 114565068 Common - binding-protein-dependent transport systems inner membrane component Sfri_3918 182 COG4662 TupA, ABC-type tungstate transport system, periplasmic component Coenzyme metabolism 114562165 Common secG preprotein translocase subunit SecG Sfri_0987 72 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 114561811 Common - Tetratricopeptide TPR_2 repeat protein Sfri_0626 14 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 114564305 Nonpathogen - hypothetical protein Sfri_3143 3 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 114561458 Nonpathogen - hypothetical protein Sfri_0270 8 None None None 114562753 Common - FAD dependent oxidoreductase Sfri_1577 78 COG2509 COG2509, Uncharacterized FAD-dependent dehydrogenases General function prediction only 114564687 Common - hypothetical protein Sfri_3535 8 None None None 114562336 Common flgA flagellar basal body P-ring biosynthesis protein FlgA Sfri_1158 25 COG1261 FlgA, Flagellar basal body P-ring biosynthesis protein Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 114562973 Common - CrcB protein Sfri_1798 181 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 114563100 Common - acriflavin resistance protein Sfri_1929 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 114564070 Common thrA bifunctional aspartokinase I/homeserine dehydrogenase I Sfri_2906 235 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 114564567 Common - MscS Mechanosensitive ion channel Sfri_3406 156 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 114562384 Common - CheW protein Sfri_1206 14 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 114564833 Common - hypothetical protein Sfri_3681 1 None None None 114561712 Common - hypothetical protein Sfri_0526 10 None None None 114563925 Common - dTDP-glucose 4,6-dehydratase Sfri_2760 231 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 114564560 Common - band 7 protein Sfri_3399 217 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 114564122 Common - protein of unknown function DUF547 Sfri_2958 25 None None None 114562414 Nonpathogen - protein of unknown function DUF1058 Sfri_1236 5 COG3103 COG3103, SH3 domain protein Signal transduction mechanisms 114563754 Common - transcriptional regulator, LysR family protein Sfri_2588 192 COG0583 LysR, Transcriptional regulator Transcription 114563090 Common - hypothetical protein Sfri_1919 10 None None None 114564240 Common - 4-hydroxythreonine-4-phosphate dehydrogenase Sfri_3078 159 COG1995 PdxA, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 114564283 Common - ABC-type phosphate/phosphonate transport system Sfri_3121 41 COG3221 PhnD, ABC-type phosphate/phosphonate transport system, periplasmic component Inorganic ion transport and metabolism 114562980 Common - putative DNA-binding transcriptional regulator Sfri_1805 174 COG0583 LysR, Transcriptional regulator Transcription 114563116 Common - putative transporter, BCCT family protein Sfri_1945 68 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 114564978 Common - DNA repair protein RadC Sfri_3828 178 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 114564740 Nonpathogen - hypothetical protein Sfri_3588 1 None None None 114565129 Common - ABC-2 type transporter Sfri_3979 20 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 114564099 Common - RNA polymerase sigma factor RpoE Sfri_2935 175 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 114561205 Common - Protoporphyrinogen oxidase Sfri_0017 34 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 114561566 Common - DNA adenine methylase Sfri_0378 96 COG0338 Dam, Site-specific DNA methylase DNA replication, recombination, and repair 114564971 Common - hypothetical protein Sfri_3821 4 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 114564333 Common - esterase, PHB depolymerase family protein Sfri_3172 30 COG3509 LpqC, Poly(3-hydroxybutyrate) depolymerase Secondary metabolites biosynthesis, transport, and catabolism 114562579 Common - peptide methionine sulfoxide reductase Sfri_1402 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 114563512 Common sucC succinyl-CoA synthetase subunit beta Sfri_2341 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 114564747 Common - hypothetical protein Sfri_3595 127 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 114561552 Common rpoZ DNA-directed RNA polymerase subunit omega Sfri_0364 93 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 114562218 Common - thiamine-monophosphate kinase Sfri_1040 198 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 114564676 Common - Methyltransferase type 12 Sfri_3523 84 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 114562928 Common - hypothetical protein Sfri_1753 9 COG3308 COG3308, Predicted membrane protein Function unknown 114562655 Common bioD dithiobiotin synthetase Sfri_1478 125 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 114562103 Common - permease YjgP/YjgQ family protein Sfri_0925 95 COG0795 COG0795, Predicted permeases General function prediction only 114564433 Common - diguanylate cyclase/phosphodiesterase Sfri_3272 179 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114563296 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Sfri_2125 230 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 114563467 Common - FAD linked oxidase domain protein Sfri_2296 200 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 114562342 Common flgE flagellar hook protein FlgE Sfri_1164 126 COG1749 FlgE, Flagellar hook protein FlgE Cell motility and secretion 114561422 Common - transcription elongation factor GreB Sfri_0234 196 COG0782 GreA, Transcription elongation factor Transcription 114565064 Common - hypothetical protein Sfri_3914 98 COG1738 COG1738, Uncharacterized conserved protein Function unknown 114564103 Common nhaR transcriptional activator NhaR Sfri_2939 122 COG0583 LysR, Transcriptional regulator Transcription 114562808 Common - GCN5-related N-acetyltransferase Sfri_1632 102 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 114561485 Common - drug resistance transporter, Bcr/CflA subfamily Sfri_0297 212 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 114561334 Common - elongation factor Tu Sfri_0146 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 114564031 Common - protein of unknown function DUF885 Sfri_2867 44 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 114563459 Common - NADH dehydrogenase (quinone) Sfri_2288 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 114563987 Common - UTP-glucose-1-phosphate uridylyltransferase Sfri_2823 230 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 114564274 Common - peptidyl-prolyl cis-trans isomerase, cyclophilin type Sfri_3112 190 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 114561305 Common nudE ADP-ribose diphosphatase NudE Sfri_0117 118 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 114561445 Common - Cytochrome-c oxidase Sfri_0257 174 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 114561504 Nonpathogen - hypothetical protein Sfri_0316 4 None None None 114562361 Common fliG flagellar motor switch protein G Sfri_1183 125 COG1536 FliG, Flagellar motor switch protein Cell motility and secretion 114564777 Common - protein of unknown function DUF81 Sfri_3625 41 COG0730 COG0730, Predicted permeases General function prediction only 114563172 Common - Polysulphide reductase, NrfD Sfri_2001 30 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 114563480 Common ushA bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor Sfri_2309 137 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 114563160 Common - hypothetical protein Sfri_1989 28 None None None 114562636 Common - MotA/TolQ/ExbB proton channel Sfri_1459 150 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 114561778 Common - peptidase S41 Sfri_0592 14 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 114561903 Common - 4-diphosphocytidyl-2C-methyl-D-erythritol kinase Sfri_0720 192 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 114561399 Common - transcriptional regulator, MerR family protein Sfri_0211 137 COG0789 SoxR, Predicted transcriptional regulators Transcription 114562698 Common - histidine triad (HIT) protein Sfri_1522 225 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 114561394 Common - DoxX family protein Sfri_0206 32 COG2259 COG2259, Predicted membrane protein Function unknown 114561950 Common - TonB-dependent receptor, plug Sfri_0769 86 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 114561615 Common - ATP-dependent DNA helicase Rep Sfri_0428 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 114561640 Common - helix-turn-helix, Fis-type Sfri_0453 96 COG2901 Fis, Factor for inversion stimulation Fis, transcriptional activator Transcription / DNA replication, recombination, and repair 114562887 Common - MscS Mechanosensitive ion channel Sfri_1712 228 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 114561678 Common - hypothetical protein Sfri_0491 3 None None None 114562542 Common - hypothetical protein Sfri_1364 14 None None None 114564390 Common - hypothetical protein Sfri_3229 17 COG5395 COG5395, Predicted membrane protein Function unknown 114563996 Common - glycosyl transferase, family 2 Sfri_2832 117 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 114562058 Common - cob(I)yrinic acid a,c-diamide adenosyltransferase Sfri_0880 142 COG2109 BtuR, ATP:corrinoid adenosyltransferase Coenzyme metabolism 114562093 Common - SEC-C motif domain protein Sfri_0915 9 COG3318 COG3318, Predicted metal-binding protein related to the C-terminal domain of SecA General function prediction only 114563763 Common tig trigger factor Sfri_2597 216 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 114564328 Common - Alpha/beta hydrolase fold-3 domain protein Sfri_3167 123 COG0657 Aes, Esterase/lipase Lipid metabolism 114564480 Common - phosphatidylserine decarboxylase Sfri_3319 97 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 114564591 Common - hypothetical protein Sfri_3432 5 None None None 114565075 Common - hypothetical protein Sfri_3925 18 None None None 114562086 Common - Uracil-DNA glycosylase superfamily Sfri_0908 58 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 114561230 Common - coproporphyrinogen III oxidase Sfri_0042 203 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 114563727 Common - transcriptional regulator, LysR family protein Sfri_2560 158 COG0583 LysR, Transcriptional regulator Transcription 114561314 Common - glutamate racemase Sfri_0126 190 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 114561985 Common - ThiJ/PfpI domain protein Sfri_0805 92 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 114563176 Nonpathogen - hypothetical protein Sfri_2005 2 None None None 114564072 Common - hypothetical protein Sfri_2908 2 None None None 114563567 Common - lipoprotein releasing system, transmembrane protein, LolC/E family protein Sfri_2397 194 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 114563973 Common - FlhB domain protein Sfri_2809 68 COG2257 COG2257, Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB Function unknown 114562823 Common - hypothetical protein Sfri_1647 7 None None None 114563320 Common - peptidase M14, carboxypeptidase A Sfri_2149 30 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 114563327 Common - hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha subunit Sfri_2156 148 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 114563132 Common - ABC transporter related Sfri_1961 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 114563781 Common - glutaminyl-tRNA synthetase Sfri_2615 244 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 114564599 Common - phage integrase family protein Sfri_3442 8 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 114562150 Common - peptidase M48, Ste24p Sfri_0972 126 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 114561284 Common - molybdopterin biosynthesis protein MoeB Sfri_0096 209 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 114562997 Common - hypothetical protein Sfri_1822 28 None None None 114562322 Common - cyd operon protein YbgT Sfri_1144 22 COG4890 COG4890, Predicted outer membrane lipoprotein Function unknown 114564079 Common tyrA bifunctional chorismate mutase/prephenate dehydrogenase Sfri_2915 71 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 114565047 Common - flavocytochrome c Sfri_3897 207 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 114562593 Common - methyl-accepting chemotaxis sensory transducer Sfri_1416 146 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 114561689 Common - porin, Gram-negative type Sfri_0503 35 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 114562172 Common - diguanylate cyclase/phosphodiesterase Sfri_0994 178 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114564023 Common - twitching motility protein Sfri_2859 213 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 114562267 Common - NADH:flavin oxidoreductase/NADH oxidase Sfri_1089 177 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 114561226 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Sfri_0038 184 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 114561574 Common - transport-associated Sfri_0386 59 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only