Methylobacillus flagellatus KT, complete genome NC_007947 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 91775685 Common - DNA repair protein RadA Mfla_1332 213 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 91775865 Common - pyruvate carboxylase subunit B Mfla_1512 208 COG5016 COG5016, Pyruvate/oxaloacetate carboxyltransferase Energy production and conversion 91775473 Common - Ferritin and Dps Mfla_1120 145 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 91775057 Common - protein of unknown function DUF214 Mfla_0704 32 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 91776220 Common - hypothetical protein Mfla_1868 109 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 91776988 Common - DegT/DnrJ/EryC1/StrS aminotransferase Mfla_2640 181 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 91774621 Common - elongation factor Tu Mfla_0265 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 91775050 Common - protein of unknown function DUF1243 Mfla_0697 34 COG3165 COG3165, Uncharacterized protein conserved in bacteria Function unknown 91775339 Common - uncharacterized lipoprotein Mfla_0986 33 COG3317 NlpB, Uncharacterized lipoprotein Cell envelope biogenesis, outer membrane 91775668 Common - MltA-interacting MipA Mfla_1315 29 COG3713 OmpV, Outer membrane protein V Cell envelope biogenesis, outer membrane 91775194 Common - beta-lactamase-like protein Mfla_0841 64 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 91776766 Common - hypothetical protein Mfla_2416 8 None None None 91776104 Common - UvrD/REP helicase Mfla_1751 212 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 91775941 Common - Small GTP-binding protein domain Mfla_1588 220 COG2262 HflX, GTPases General function prediction only 91774941 Common - Inositol phosphatase/fructose-1,6-bisphosphatase Mfla_0586 108 COG0158 Fbp, Fructose-1,6-bisphosphatase Carbohydrate transport and metabolism 91775992 Common - type II secretion system protein Mfla_1639 64 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 91775674 Common - ribonuclease, Rne/Rng family Mfla_1321 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 91776275 Common - hypothetical protein Mfla_1923 25 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 91776647 Common - molybdopterin-guanine dinucleotide biosynthesis protein A Mfla_2295 150 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 91775506 Common - hypothetical protein Mfla_1153 5 None None None 91777095 Common - ATP synthase F1, delta subunit Mfla_2747 182 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 91776118 Common - Urease accessory protein UreF Mfla_1765 82 COG0830 UreF, Urease accessory protein UreF Posttranslational modification, protein turnover, chaperones 91774648 Common rpsN 30S ribosomal protein S14 Mfla_0292 206 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 91776745 Common - periplasmic sensor signal transduction histidine kinase Mfla_2395 219 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 91774898 Common - twin-arginine translocation protein TatB Mfla_0543 30 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 91776373 Common - polysaccharide biosynthesis protein Mfla_2021 46 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 91776614 Common lpxC UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase Mfla_2262 139 COG0774 LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase Cell envelope biogenesis, outer membrane 91774862 Common - glutathione S-transferase-like protein Mfla_0507 26 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 91775783 Nonpathogen - copper resistance D Mfla_1430 1 None None None 91774567 Common - acriflavin resistance protein Mfla_0211 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 91775682 Common - ribosomal protein L9 Mfla_1329 215 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 91775894 Common - binding-protein-dependent transport systems inner membrane component Mfla_1541 220 COG4239 COG4239, ABC-type uncharacterized transport system, permease component General function prediction only 91775627 Common - polysaccharide export protein Mfla_1274 29 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 91776449 Common - riboflavin synthase subunit alpha Mfla_2097 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 91774474 Common - CobN/magnesium chelatase Mfla_0118 89 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 91775493 Common - protein of unknown function DUF541 Mfla_1140 28 COG2859 COG2859, Uncharacterized protein conserved in bacteria Function unknown 91775300 Nonpathogen - protein of unknown function DUF1328 Mfla_0947 1 None None None 91776341 Common - TonB-dependent receptor Mfla_1989 119 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 91774982 Common - OmpW Mfla_0627 72 COG3047 OmpW, Outer membrane protein W Cell envelope biogenesis, outer membrane 91775718 Common - Lysine exporter protein (LYSE/YGGA) Mfla_1365 106 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 91774365 Common - hypothetical protein Mfla_0009 34 COG4188 COG4188, Predicted dienelactone hydrolase General function prediction only 91775655 Common - glutamine amidotransferase Mfla_1302 111 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 91776300 Common fliA flagellar biosynthesis sigma factor Mfla_1948 212 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 91775479 Common - hypothetical protein Mfla_1126 11 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 91776332 Common - putative flagellar biosynthetic protein Mfla_1980 103 COG2257 COG2257, Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB Function unknown 91774854 Common - Tetratricopeptide TPR_2 Mfla_0499 73 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 91776225 Common - putative transcriptional regulator Mfla_1873 150 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 91774554 Common - Tyrosine recombinase XerC Mfla_0198 230 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 91774515 Common - transcriptional regulator, LuxR family Mfla_0159 10 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 91777090 Common - UDP-N-acetylglucosamine pyrophosphorylase Mfla_2742 226 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 91776393 Common - methanol dehydrogenase, beta subunit Mfla_2041 7 None None None 91776491 Common - isocitrate/isopropylmalate dehydrogenase Mfla_2139 222 COG0538 Icd, Isocitrate dehydrogenases Energy production and conversion 91775711 Common - GTP cyclohydrolase II Mfla_1358 201 COG0807 RibA, GTP cyclohydrolase II Coenzyme metabolism 91776423 Common - TrkA-N Mfla_2071 81 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 91775414 Common - glucose-6-phosphate 1-dehydrogenase Mfla_1061 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 91774596 Common - toluene tolerance Mfla_0240 85 COG2854 Ttg2D, ABC-type transport system involved in resistance to organic solvents, auxiliary component Secondary metabolites biosynthesis, transport, and catabolism 91775275 Common - Competence protein ComEA helix-hairpin-helix region Mfla_0922 137 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 91775721 Common - Glucose-1-phosphate adenylyltransferase Mfla_1368 197 COG0448 GlgC, ADP-glucose pyrophosphorylase Carbohydrate transport and metabolism 91775740 Common - twitching motility protein Mfla_1387 207 COG5008 PilU, Tfp pilus assembly protein, ATPase PilU Cell motility and secretion / Intracellular trafficking and secretion 91775619 Common - Radical SAM Mfla_1266 106 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 91776418 Common - hypothetical protein Mfla_2066 34 COG4255 COG4255, Uncharacterized protein conserved in bacteria Function unknown 91775701 Common - Type I secretion system ATPase, PrtD Mfla_1348 249 COG4618 ArpD, ABC-type protease/lipase transport system, ATPase and permease components General function prediction only 91776136 Common - nitrilotriacetate monooxygenase component A Mfla_1784 72 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 91776678 Common - metalloendopeptidase, putative, glycoprotease family Mfla_2326 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 91775307 Common - DEAD/DEAH box helicase-like protein Mfla_0954 236 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 91775572 Common - anticodon nuclease Mfla_1219 15 COG4694 COG4694, Uncharacterized protein conserved in bacteria Function unknown 91777060 Nonpathogen - hypothetical protein Mfla_2712 1 None None None 91777053 Common - transcriptional regulators, TraR/DksA family Mfla_2705 2 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 91776029 Common - short-chain alcohol dehydrogenase Mfla_1676 25 COG3007 COG3007, Uncharacterized paraquat-inducible protein B Function unknown 91775970 Common - ABC transporter related Mfla_1617 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 91776416 Common - Triosephosphate isomerase Mfla_2064 216 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 91776356 Nonpathogen - hypothetical protein Mfla_2004 3 None None None 91775376 Common - Glycogen/starch/alpha-glucan phosphorylase Mfla_1023 142 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 91775258 Common - threonine synthase Mfla_0905 136 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 91775454 Nonpathogen - hypothetical protein Mfla_1101 1 None None None 91774779 Common - PepSY-associated TM helix Mfla_0424 28 COG3295 COG3295, Uncharacterized protein conserved in bacteria Function unknown 91776524 Common - putative nitrate transporter component, nrtA Mfla_2172 111 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 91775551 Common - diguanylate cyclase (GGDEF domain) Mfla_1198 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 91775562 Common - ribonuclease BN Mfla_1209 74 COG1295 Rbn, Predicted membrane protein Function unknown 91774545 Common - DNA processing protein DprA, putative Mfla_0189 210 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 91776967 Common - protein of unknown function DUF182 Mfla_2618 114 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 91774976 Common - hypothetical protein Mfla_0621 3 COG5583 COG5583, Uncharacterized small protein Function unknown 91777065 Common - conserved hypothetical phage-related protein Mfla_2717 47 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 91775104 Common - Chaperone DnaK Mfla_0751 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 91776673 Common - transcriptional regulator, LysR family Mfla_2321 164 COG0583 LysR, Transcriptional regulator Transcription 91775546 Common - hypothetical protein Mfla_1193 10 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 91775189 Common - fkbp-type peptidyl-prolyl cis-trans isomerase Mfla_0836 128 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 91774462 Common - methionine aminopeptidase, type I Mfla_0106 248 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 91776206 Nonpathogen - hypothetical protein Mfla_1854 4 None None None 91775363 Common recO DNA repair protein RecO Mfla_1010 60 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 91776753 Common - Biopolymer transport protein ExbD/TolR Mfla_2403 139 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 91776777 Nonpathogen - hypothetical protein Mfla_2427 7 None None None 91774601 Common - Glutaredoxin-related protein Mfla_0245 127 COG0278 COG0278, Glutaredoxin-related protein Posttranslational modification, protein turnover, chaperones 91774404 Common - Guanylate kinase Mfla_0048 214 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 91775221 Common - phosphopantethiene--protein transferase domain Mfla_0868 95 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 91774585 Common - pteridine reductase Mfla_0229 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 91776283 Common - CheD, stimulates methylation of MCP proteins Mfla_1931 87 COG1871 CheD, Chemotaxis protein; stimulates methylation of MCP proteins Cell motility and secretion / Signal transduction mechanisms 91775123 Common - phosphoheptose isomerase Mfla_0770 123 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 91776699 Common - ABC transporter related Mfla_2347 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 91775430 Nonpathogen - hypothetical protein Mfla_1077 1 None None None 161611349 Common - transcriptional regulator, XRE family Mfla_2252 207 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 91775962 Common - hypothetical protein Mfla_1609 5 None None None 91774629 Common - DNA-directed RNA polymerase subunit beta' Mfla_0273 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 91776310 Common - Flagellar basal-body rod FlgF Mfla_1958 123 COG4787 FlgF, Flagellar basal body rod protein Cell motility and secretion 91776619 Common murB UDP-N-acetylenolpyruvoylglucosamine reductase Mfla_2267 206 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 91774430 Common - two component, sigma54 specific, transcriptional regulator, Fis family Mfla_0074 169 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 91776237 Common - nitrogen regulatory protein P-II (GlnB, GlnK) Mfla_1885 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 91775847 Common - Resolvase-like protein Mfla_1494 118 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 91776347 Common - Lactaldehyde dehydrogenase Mfla_1995 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 91774995 Common - transcriptional regulator, BadM/Rrf2 family Mfla_0640 149 COG1959 COG1959, Predicted transcriptional regulator Transcription 91776324 Common fliL flagellar basal body-associated protein FliL Mfla_1972 31 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 91774611 Common - Phosphoribosyl-AMP cyclohydrolase Mfla_0255 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 91776069 Nonpathogen - hypothetical protein Mfla_1716 1 None None None 91775695 Common - type II secretion system protein Mfla_1342 139 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 91774908 Nonpathogen - hypothetical protein Mfla_0553 1 None None None 91775883 Common - ribosomal protein S2 Mfla_1530 229 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 91777043 Common - hypothetical protein Mfla_2695 3 None None None 91776152 Common - putative transcriptional regulator Mfla_1800 140 COG1733 COG1733, Predicted transcriptional regulators Transcription 91776117 Common - urease accessory protein UreG Mfla_1764 154 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 91775311 Common - alkylphosphonate utilization operon protein PhnA Mfla_0958 93 COG2824 PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism Inorganic ion transport and metabolism 91776471 Common - acetolactate synthase, large subunit, biosynthetic type Mfla_2119 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 91775607 Common - two component, sigma54 specific, transcriptional regulator, Fis family Mfla_1254 223 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 91774964 Common - Sulphate transport system permease protein 1 Mfla_0609 249 COG1118 CysA, ABC-type sulfate/molybdate transport systems, ATPase component Inorganic ion transport and metabolism 91777004 Common - multi-sensor hybrid histidine kinase Mfla_2656 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 91776031 Common - Cyclopropane-fatty-acyl-phospholipid synthase Mfla_1678 128 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 91775529 Common - restriction modification system DNA specificity domain Mfla_1176 73 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 91775343 Common - HAD-superfamily subfamily IIA hydrolase, hypothetical 2 Mfla_0990 103 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 91776712 Common - putative signal-transduction protein with CBS domains Mfla_2360 180 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 91776685 Common - 16S rRNA processing protein RimM Mfla_2333 178 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 91774533 Common - deoxyguanosinetriphosphate triphosphohydrolase-like protein Mfla_0177 159 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 91776556 Common - hypothetical protein Mfla_2204 113 COG1806 COG1806, Uncharacterized protein conserved in bacteria Function unknown 91777101 Common - Cobyrinic acid a,c-diamide synthase Mfla_2753 232 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 91776239 Common - Ankyrin Mfla_1887 119 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 91774389 Common - protein of unknown function DUF513, hemX Mfla_0033 55 COG2959 HemX, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 91774919 Common - hypothetical protein Mfla_0564 4 None None None 91775597 Common - CheW protein Mfla_1244 27 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 91774382 Common - 3-dehydroquinate dehydratase Mfla_0026 170 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 91776664 Common - cytochrome c, class I Mfla_2312 10 None None None 91776514 Common - bioH protein Mfla_2162 164 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 91775795 Common - fatty acid beta hydroxylase (cytochrome P450) Mfla_1442 20 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 91776123 Common - Urease accessory protein UreD Mfla_1770 76 COG0829 UreH, Urease accessory protein UreH Posttranslational modification, protein turnover, chaperones 91776404 Common - NADH-ubiquinone/plastoquinone oxidoreductase, chain 6 Mfla_2052 74 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 91776658 Common - TonB-like protein Mfla_2306 38 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 91774948 Common - Iojap-related protein Mfla_0593 201 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 91774526 Common - transcriptional regulator, TetR family Mfla_0170 78 COG1309 AcrR, Transcriptional regulator Transcription 91776587 Common - peptidase M23B Mfla_2235 191 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 91774642 Common rplP 50S ribosomal protein L16 Mfla_0286 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 91774536 Common - protein of unknown function DUF1275 Mfla_0180 17 COG3619 COG3619, Predicted membrane protein Function unknown 91775016 Nonpathogen - hypothetical protein Mfla_0661 1 None None None 91776140 Common - hypothetical protein Mfla_1788 110 COG0397 COG0397, Uncharacterized conserved protein Function unknown 91776466 Common - NUDIX hydrolase Mfla_2114 56 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 91776383 Common - TonB-dependent receptor, plug Mfla_2031 27 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 91774652 Common rpsE 30S ribosomal protein S5 Mfla_0296 248 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 91774452 Common - putative hydroxylase Mfla_0096 44 COG3128 PiuC, Uncharacterized iron-regulated protein Function unknown 91776801 Common - protein of unknown function DUF86 Mfla_2451 52 COG2361 COG2361, Uncharacterized conserved protein Function unknown 91775615 Common - molybdopterin converting factor, subunit 1 Mfla_1262 84 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 91774507 Nonpathogen - protein of unknown function DUF1555 Mfla_0151 1 None None None 91776735 Common - protein of unknown function DUF502 Mfla_2385 84 COG2928 COG2928, Uncharacterized conserved protein Function unknown 91776993 Common - acetyltransferase Mfla_2645 194 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 91776498 Common - peptidase M24 Mfla_2146 237 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 91775946 Common - secretion protein HlyD Mfla_1593 161 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 91775594 Common - hypothetical protein Mfla_1241 59 COG3287 COG3287, Uncharacterized conserved protein Function unknown 91776526 Common - putative acyl-CoA dehydrogenase Mfla_2174 123 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 91774449 Common - SirA-like protein Mfla_0093 127 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 91775858 Common - 3-oxoacyl-(acyl-carrier-protein) reductase Mfla_1505 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 91776021 Common - protein of unknown function DUF853, NPT hydrolase putative Mfla_1668 77 COG0433 COG0433, Predicted ATPase General function prediction only 91774704 Common - phosphoribosylamine--glycine ligase Mfla_0348 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 91776363 Common - dTDP-4-dehydrorhamnose reductase Mfla_2011 172 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 91775073 Common - formate dehydrogenase, alpha subunit Mfla_0720 214 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 91775452 Common - Pseudouridine synthase, Rsu Mfla_1099 189 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 91775087 Common - peptidase M16-like protein Mfla_0734 199 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 91776405 Common - NADH dehydrogenase subunit I Mfla_2053 189 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 91776093 Common - hypothetical protein Mfla_1740 7 None None None 91776494 Common - type II secretion system protein Mfla_2142 151 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 91775234 Common - protein of unknown function DUF1234 Mfla_0881 22 COG3545 COG3545, Predicted esterase of the alpha/beta hydrolase fold General function prediction only 91775264 Common - two component, sigma54 specific, transcriptional regulator, Fis family Mfla_0911 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 91776254 Common - hypothetical protein Mfla_1902 15 None None None 91774487 Common - Ppx/GppA phosphatase Mfla_0131 179 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 91776256 Common - glycine cleavage T protein (aminomethyl transferase) Mfla_1904 153 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 91774848 Common - NusB antitermination factor Mfla_0493 168 COG0781 NusB, Transcription termination factor Transcription 91776050 Common - tryptophan synthase, alpha subunit Mfla_1697 217 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 91776960 Common - alpha amylase, catalytic region Mfla_2611 156 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 91775132 Common - carbamoyl-phosphate synthase, large subunit Mfla_0779 237 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 91774569 Common - N-acetyl-anhydromuranmyl-L-alanine amidase Mfla_0213 107 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 91776845 Common - Rod shape-determining protein RodA Mfla_2495 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 91774685 Common - response regulator receiver (CheY-like) and ANTAR domain protein Mfla_0329 70 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 91776012 Common - protein of unknown function DUF201 Mfla_1659 14 COG2232 COG2232, Predicted ATP-dependent carboligase related to biotin carboxylase General function prediction only 91776912 Common - Glutamate--ammonia ligase Mfla_2562 224 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 91776589 Common - protein of unknown function DUF81 Mfla_2237 101 COG0730 COG0730, Predicted permeases General function prediction only 91775146 Common - Phosphate transport system permease protein 2 Mfla_0793 219 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 91775337 Nonpathogen - Lip Mfla_0984 1 None None None 91775435 Common - Heavy metal translocating P-type ATPase Mfla_1082 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 91774784 Common - diguanylate cyclase (GGDEF domain) Mfla_0429 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 91775586 Common - ferric uptake regulator, FUR family Mfla_1233 71 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 91775987 Common - small multidrug resistance protein Mfla_1634 138 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 91776864 Common - ammonium transporter Mfla_2514 202 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 91776810 Common - Fimbrial assembly Mfla_2460 46 COG3166 PilN, Tfp pilus assembly protein PilN Cell motility and secretion / Intracellular trafficking and secretion 91775558 Nonpathogen - hypothetical protein Mfla_1205 2 None None None 91775766 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Mfla_1413 163 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 91774810 Common - hypothetical protein Mfla_0455 4 COG4583 COG4583, Sarcosine oxidase gamma subunit Amino acid transport and metabolism 91775840 Common - putative hydrolase protein Mfla_1487 59 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 91775653 Nonpathogen - hypothetical protein Mfla_1300 1 None None None 91776452 Common - Holliday junction resolvase-like protein Mfla_2100 191 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 91776630 Common - protein of unknown function UPF0040 Mfla_2278 147 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 91775752 Common - sulfatase Mfla_1399 69 COG1368 MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily Cell envelope biogenesis, outer membrane 91775011 Nonpathogen - osmotically inducible lipoprotein Mfla_0656 1 None None None 91775113 Common - 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase Mfla_0760 126 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 91776036 Common - pyrroloquinoline quinone biosynthesis protein PqqB Mfla_1683 36 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 91774914 Common - heat shock protein Hsp20 Mfla_0559 68 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 91776439 Common - 3-deoxy-D-manno-octulosonate cytidylyltransferase Mfla_2087 143 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 91775097 Common - acriflavin resistance protein Mfla_0744 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 91775140 Nonpathogen - hypothetical protein Mfla_0787 5 None None None 91775005 Common - PhoH-like protein Mfla_0650 199 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 91774695 Common - prolipoprotein diacylglyceryl transferase Mfla_0339 209 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 91775891 Common - nitroreductase Mfla_1538 63 COG0778 NfnB, Nitroreductase Energy production and conversion 91775849 Common - putative hydrolase protein Mfla_1496 88 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 91775829 Common - histone deacetylase superfamily Mfla_1476 162 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 91775030 Common - ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5 Mfla_0677 193 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 91775592 Common - Phytanoyl-CoA dioxygenase Mfla_1239 7 COG5285 COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin Secondary metabolites biosynthesis, transport, and catabolism 91776179 Nonpathogen - hypothetical protein Mfla_1827 1 None None None 91775043 Common - von Willebrand factor, type A Mfla_0690 11 None None None 91776475 Common - dinucleoside polyphosphate hydrolase Mfla_2123 112 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 91774419 Common - peptidase M23B Mfla_0063 187 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 91776995 Common - hypothetical protein Mfla_2647 84 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 91776645 Common - putative transcriptional regulator, ModE family Mfla_2293 57 COG2005 ModE, N-terminal domain of molybdenum-binding protein General function prediction only 91775103 Common - Chaperone DnaJ Mfla_0750 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 91777024 Common - short chain dehydrogenase Mfla_2676 232 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 91775393 Common - Rhs element Vgr protein Mfla_1040 23 COG3501 VgrG, Uncharacterized protein conserved in bacteria Function unknown 91775604 Common - ABC transporter related Mfla_1251 249 COG4181 COG4181, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 91775358 Common - Peptidase S26A, signal peptidase I Mfla_1005 212 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 91776196 Nonpathogen - protein of unknown function DUF1555 Mfla_1844 1 None None None 91774646 Common rplX 50S ribosomal protein L24 Mfla_0290 210 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 91775037 Common - hypothetical protein Mfla_0684 25 COG3225 GldG, ABC-type uncharacterized transport system involved in gliding motility, auxiliary component Cell motility and secretion 91775973 Common ispG 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase Mfla_1620 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 91774710 Common - ThiJ/PfpI Mfla_0354 77 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 91775785 Common - cytochrome c, class I Mfla_1432 64 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 91774736 Common - OsmC-like protein Mfla_0380 87 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 91774888 Nonpathogen - hypothetical protein Mfla_0533 1 None None None 91774676 Common - protein serine/threonine phosphatases Mfla_0320 153 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 91776797 Common - glutamine synthetase, type I Mfla_2447 224 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 91776703 Common - TonB-dependent receptor Mfla_2351 123 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 91775157 Common - Fe-S protein assembly chaperone HscA Mfla_0804 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 91775954 Nonpathogen - protein of unknown function DUF1555 Mfla_1601 1 None None None 91776623 Common - UDP-N-acetylmuramoylalanine--D-glutamate ligase Mfla_2271 211 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 91776924 Common - Pirin-like protein Mfla_2574 146 COG1741 COG1741, Pirin-related protein General function prediction only 91775960 Common - ABC transporter related Mfla_1607 249 COG4559 COG4559, ABC-type hemin transport system, ATPase component Inorganic ion transport and metabolism 91774803 Common - putative signal transduction histidine kinase Mfla_0448 119 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 91776923 Common - isochorismatase hydrolase Mfla_2573 84 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 91776402 Common - proton-translocating NADH-quinone oxidoreductase, chain L Mfla_2050 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 91776005 Common - formaldehyde-activating enzyme Mfla_1652 25 COG1795 COG1795, Uncharacterized conserved protein Function unknown 91777032 Nonpathogen - hypothetical protein Mfla_2684 1 None None None 91776432 Common - putative transcriptional acitvator, Baf Mfla_2080 95 COG1521 COG1521, Putative transcriptional regulator, homolog of Bvg accessory factor Transcription 91777039 Nonpathogen - hypothetical protein Mfla_2691 2 None None None 91775090 Common - Coenzyme A biosynthesis protein Mfla_0737 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 91776578 Common - Dephospho-CoA kinase Mfla_2226 206 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 91774410 Common - 4-hydroxybenzoate polyprenyl transferase Mfla_0054 156 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 91775379 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Mfla_1026 21 None None None 91776724 Common - secretion protein HlyD Mfla_2372 164 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 91776080 Common - acetyl-CoA synthetase Mfla_1727 217 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 91775923 Common - methyl-accepting chemotaxis sensory transducer Mfla_1570 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 91775150 Common - lysyl-tRNA synthetase Mfla_0797 249 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 91776334 Common - flagellar protein FliT Mfla_1982 13 None None None 91776807 Common - type II and III secretion system protein Mfla_2457 140 COG4796 HofQ, Type II secretory pathway, component HofQ Intracellular trafficking and secretion 91775464 Common - twitching motility protein Mfla_1111 219 COG5008 PilU, Tfp pilus assembly protein, ATPase PilU Cell motility and secretion / Intracellular trafficking and secretion 91775061 Common - TonB-dependent receptor, plug Mfla_0708 53 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 91775068 Common - periplasmic sensor signal transduction histidine kinase Mfla_0715 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 91776019 Common - OmpA/MotB Mfla_1666 171 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 91776298 Common flhF flagellar biosynthesis regulator FlhF Mfla_1946 129 COG1419 FlhF, Flagellar GTP-binding protein Cell motility and secretion 91775386 Common - L-sorbosone dehydrogenase, putative Mfla_1033 119 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 91775277 Common - hypothetical protein Mfla_0924 62 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 91776852 Common - protein of unknown function DUF21 Mfla_2502 213 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 91775383 Common - diguanylate cyclase (GGDEF domain) Mfla_1030 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 91776836 Common - T/U mismatch-specific DNA glycosylase Mfla_2486 41 COG3663 Mug, G:T/U mismatch-specific DNA glycosylase DNA replication, recombination, and repair 91775932 Common - hypothetical protein Mfla_1579 26 COG1891 COG1891, Uncharacterized protein conserved in archaea Function unknown 91776552 Nonpathogen - hypothetical protein Mfla_2200 1 None None None 91776686 Common - ribosomal protein S16 Mfla_2334 211 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 91774378 Common - Zinc finger/thioredoxin putative Mfla_0022 26 None None None 91774604 Common - Histidinol dehydrogenase Mfla_0248 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 91775409 Nonpathogen - hypothetical protein Mfla_1056 1 None None None 91774371 Common - GCN5-related N-acetyltransferase Mfla_0015 69 COG0456 RimI, Acetyltransferases General function prediction only 91776855 Common - NADPH-dependent FMN reductase Mfla_2505 113 COG0431 COG0431, Predicted flavoprotein General function prediction only 91775319 Nonpathogen - hypothetical protein Mfla_0966 1 None None None 91775209 Common - RNA polymerase sigma factor RpoE Mfla_0856 174 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 91775420 Common - orotidine 5'-phosphate decarboxylase Mfla_1067 169 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 91775775 Common - Endonuclease/exonuclease/phosphatase Mfla_1422 72 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 91777103 Common - tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA Mfla_2755 191 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 91775625 Common - NAD-dependent epimerase/dehydratase Mfla_1272 229 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 91775481 Common - recombination factor protein RarA Mfla_1128 241 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 91776072 Common - Sel1 Mfla_1719 5 None None None 91776569 Common obgE GTPase ObgE Mfla_2217 233 COG0536 Obg, Predicted GTPase General function prediction only 91776268 Common - hypothetical protein Mfla_1916 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 91776184 Common - NADPH-dependent FMN reductase Mfla_1832 116 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 91775270 Common - glucose-6-phosphate 1-dehydrogenase Mfla_0917 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 91775866 Common - maf protein Mfla_1513 191 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 91776903 Common - outer membrane efflux protein Mfla_2553 117 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91776887 Common - periplasmic sensor signal transduction histidine kinase Mfla_2537 23 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 91774934 Common - cation antiporter Mfla_0579 77 COG1863 MnhE, Multisubunit Na+/H+ antiporter, MnhE subunit Inorganic ion transport and metabolism 91775203 Common - electron transport complex, RnfABCDGE type, B subunit Mfla_0850 118 COG2878 COG2878, Predicted NADH:ubiquinone oxidoreductase, subunit RnfB Energy production and conversion 91775321 Nonpathogen - hypothetical protein Mfla_0968 1 None None None 91777085 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) Mfla_2737 195 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 91774833 Common - putative transmembrane protein Mfla_0478 3 None None None 91776693 Common - Biopolymer transport protein ExbD/TolR Mfla_2341 134 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 91774424 Common - ribosome-binding factor A Mfla_0068 96 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 91774456 Common - Phosphoglycerate mutase Mfla_0100 128 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 91777073 Nonpathogen - hypothetical protein Mfla_2725 1 None None None 91776511 Common - putative nicotinate-nucleotide adenylyltransferase Mfla_2159 183 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 91775948 Nonpathogen - hypothetical protein Mfla_1595 1 None None None 91774753 Common - transcriptional regulator, AraC family Mfla_0397 78 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 91776391 Common - hypothetical protein Mfla_2039 38 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 91775284 Common - arginyl-tRNA-protein transferase Mfla_0931 85 COG2935 COG2935, Putative arginyl-tRNA:protein arginylyltransferase Posttranslational modification, protein turnover, chaperones 91776829 Common - putative carbonic anhydrase, family 3 Mfla_2479 191 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 91776938 Common - MCP methyltransferase, CheR-type Mfla_2588 149 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 91777051 Common - hypothetical protein Mfla_2703 11 None None None 91776879 Common - Pseudouridine synthase, Rsu Mfla_2529 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 91774707 Common - Dihydrouridine synthase TIM-barrel protein nifR3 Mfla_0351 213 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 91776975 Nonpathogen - hypothetical protein Mfla_2627 2 None None None 91776414 Nonpathogen - hypothetical protein Mfla_2062 1 None None None 91775731 Nonpathogen - hypothetical protein Mfla_1378 7 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 91774547 Common - 5,10-methylenetetrahydrofolate reductase Mfla_0191 147 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 91776818 Common - glutamine amidotransferase of anthranilate synthase or para-aminobenzoate synthase Mfla_2468 237 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 91774816 Common - response regulator receiver (CheY-like) and ANTAR domain protein Mfla_0461 12 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 91775742 Common - TPR repeat Mfla_1389 131 COG3914 Spy, Predicted O-linked N-acetylglucosamine transferase, SPINDLY family Posttranslational modification, protein turnover, chaperones 91775305 Common - protein of unknown function DUF188 Mfla_0952 97 COG1671 COG1671, Uncharacterized protein conserved in bacteria Function unknown 91774681 Common - nitrate transport ATP-binding subunits C and D Mfla_0325 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 91775761 Common - trigger factor Mfla_1408 215 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 91776248 Common - hypothetical protein Mfla_1896 25 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 91775405 Common - Propeptide, PepSY amd peptidase M4 Mfla_1052 5 COG3212 COG3212, Predicted membrane protein Function unknown 91776786 Nonpathogen - hypothetical protein Mfla_2436 3 None None None 91774929 Common mogA molybdenum cofactor biosynthesis protein Mfla_0574 181 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 91775725 Common - glycosyl transferase, family 2 Mfla_1372 92 COG5309 COG5309, Exo-beta-1,3-glucanase Carbohydrate transport and metabolism 91776708 Common - protein of unknown function DUF6, transmembrane Mfla_2356 112 COG2962 RarD, Predicted permeases General function prediction only 91776740 Common - binding-protein-dependent transport systems inner membrane component Mfla_2390 133 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 91776536 Common - protein of unknown function DUF1058 Mfla_2184 13 COG3807 COG3807, Uncharacterized protein conserved in bacteria Function unknown 91775320 Nonpathogen - hypothetical protein Mfla_0967 1 None None None 91775802 Common - cytochrome c oxidase, subunit II Mfla_1449 158 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 91775293 Common - hypothetical protein Mfla_0940 4 COG3735 COG3735, Uncharacterized protein conserved in bacteria Function unknown 91774510 Common - ABC transporter related Mfla_0154 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 91776562 Common - integral membrane protein MviN Mfla_2210 189 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 91776662 Common - hypothetical protein Mfla_2310 53 None None None 91775677 Common - peptidase S49 Mfla_1324 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 91774794 Common - Aminomethyltransferase Mfla_0439 178 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 91775523 Common - ATPase AAA-2 Mfla_1170 215 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 91776168 Common - hypothetical protein Mfla_1816 14 None None None 91774744 Common - NLP/P60 Mfla_0388 133 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 91775981 Nonpathogen - hypothetical protein Mfla_1628 1 None None None 91775160 Common - scaffold protein Mfla_0807 155 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 91776820 Nonpathogen - hypothetical protein Mfla_2470 1 None None None 91774609 Common - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase Mfla_0253 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 91774491 Nonpathogen - hypothetical protein Mfla_0135 1 None None None 91774498 Common - sigma-54 (RpoN) Mfla_0142 145 COG1508 RpoN, DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog Transcription 91774517 Common - YbaK/prolyl-tRNA synthetase associated region Mfla_0161 50 COG2606 EbsC, Uncharacterized conserved protein Function unknown 91775378 Common - protein of unknown function DUF1234 Mfla_1025 22 COG3545 COG3545, Predicted esterase of the alpha/beta hydrolase fold General function prediction only 91776330 Common - flagellar M-ring protein FliF Mfla_1978 127 COG1766 FliF, Flagellar biosynthesis/type III secretory pathway lipoprotein Cell motility and secretion / Intracellular trafficking and secretion 91774828 Nonpathogen - hypothetical protein Mfla_0473 1 None None None 91774846 Common - DNA-3-methyladenine glycosylase I Mfla_0491 132 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 91775359 Common - putative transmembrane protein Mfla_1006 17 None None None 91776172 Common - surface antigen (D15) Mfla_1820 129 COG0729 COG0729, Outer membrane protein Cell envelope biogenesis, outer membrane 91776640 Common - diguanylate phosphodiesterase (EAL domain) Mfla_2288 161 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 91775223 Common - UBA/THIF-type NAD/FAD binding fold Mfla_0870 180 COG1179 COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Coenzyme metabolism 91776733 Common - adenine phosphoribosyltransferase Mfla_2383 167 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 91776943 Common - hypothetical protein Mfla_2593 4 None None None 91774556 Common - peptidase M48, Ste24p Mfla_0200 130 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 91775124 Common - ADP-L-glycero-D-manno-heptose-6-epimerase Mfla_0771 148 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 91775232 Common - Glycogen/starch/alpha-glucan phosphorylase Mfla_0879 142 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 91776081 Common - protein of unknown function DUF442 Mfla_1728 43 COG3453 COG3453, Uncharacterized protein conserved in bacteria Function unknown 91774374 Common - MscS Mechanosensitive ion channel Mfla_0018 71 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 91775441 Common - response regulator receiver domain protein (CheY-like) Mfla_1088 50 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 91776601 Common - transketolase Mfla_2249 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 91776057 Common leuD isopropylmalate isomerase small subunit Mfla_1704 210 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 91775416 Common - 6-phosphogluconolactonase Mfla_1063 138 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 91775313 Common - Dihydroxyacetone kinase DhaK, subunit 1 Mfla_0960 77 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 91775365 Common - phosphopantethiene--protein transferase domain Mfla_1012 95 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 91776931 Common - transcriptional regulator, MarR family Mfla_2581 14 COG1846 MarR, Transcriptional regulators Transcription 91774955 Common - poly(A) polymerase Mfla_0600 213 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 91776201 Common - ErfK/YbiS/YcfS/YnhG Mfla_1849 53 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 91775876 Common - Peptidase M50, putative membrane-associated zinc metallopeptidase Mfla_1523 209 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 91775944 Common - RND efflux system, outer membrane lipoprotein, NodT Mfla_1591 135 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91776270 Common - hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region Mfla_1918 148 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 91776597 Common - hypothetical protein Mfla_2245 2 None None None 91775134 Common - hypothetical protein Mfla_0781 21 None None None 91775605 Common - protein of unknown function DUF214 Mfla_1252 89 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 91777062 Common - hypothetical protein Mfla_2714 6 COG1414 IclR, Transcriptional regulator Transcription 91774874 Common - putative integral membrane protein Mfla_0519 20 COG3235 COG3235, Predicted membrane protein Function unknown 91776676 Common - GatB/Yqey Mfla_2324 151 COG1610 COG1610, Uncharacterized conserved protein Function unknown 91774782 Common - ApbE-like lipoprotein Mfla_0427 138 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 91776757 Nonpathogen - hypothetical protein Mfla_2407 3 None None None 91776130 Common - Formamidase Mfla_1777 62 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 91776782 Common - cobalamin biosynthesis protein CbiB Mfla_2432 100 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 91775410 Common - periplasmic sensor signal transduction histidine kinase Mfla_1057 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 91777097 Common - ATP synthase F0, C subunit Mfla_2749 63 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 91774961 Common - CRISPR-associated protein Cas1 Mfla_0606 100 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 91775907 Common - ABC transporter related Mfla_1554 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 91776349 Common ihfA integration host factor subunit alpha Mfla_1997 211 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 91775672 Common - aminotransferase, class I and II Mfla_1319 239 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 91775052 Common - protein of unknown function DUF971 Mfla_0699 52 COG3536 COG3536, Uncharacterized protein conserved in bacteria Function unknown 91776779 Common - hypothetical protein Mfla_2429 41 COG2153 ElaA, Predicted acyltransferase General function prediction only 91776371 Common - nitroreductase Mfla_2019 11 COG0778 NfnB, Nitroreductase Energy production and conversion 91776487 Common - conserved hypothetical protein, predicted peptidase aspartic family Mfla_2135 48 COG3577 COG3577, Predicted aspartyl protease General function prediction only 91775965 Common - Pseudouridine synthase, RluD Mfla_1612 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 91775504 Nonpathogen - hypothetical protein Mfla_1151 1 None None None 91774851 Common - Peptidylprolyl isomerase Mfla_0496 201 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 91775192 Common - NolW-like protein Mfla_0839 11 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 91775709 Common - protein of unknown function DUF748 Mfla_1356 44 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 91775059 Common - hypothetical protein Mfla_0706 13 None None None 91776764 Common - type II and III secretion system protein Mfla_2414 139 COG4796 HofQ, Type II secretory pathway, component HofQ Intracellular trafficking and secretion 91774435 Common - type II secretion system protein Mfla_0079 147 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 91777067 Nonpathogen - hypothetical protein Mfla_2719 1 None None None 91776948 Common - hypothetical protein Mfla_2598 5 None None None 91776704 Common - nitrilotriacetate monooxygenase, A subunit, putative Mfla_2352 73 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 91774864 Common - ATP-dependent Clp protease adaptor protein ClpS Mfla_0509 119 COG2127 COG2127, Uncharacterized conserved protein Function unknown 91776394 Common - cytochrome c, class I Mfla_2042 9 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 91776649 Common - MoeA-like, domain I and II Mfla_2297 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 91775495 Nonpathogen - hypothetical protein Mfla_1142 1 None None None 91774464 Common - hypothetical protein Mfla_0108 17 None None None 91775341 Nonpathogen - hypothetical protein Mfla_0988 4 None None None 91776139 Common - Conserved TM helix Mfla_1787 35 None None None 91775657 Common - outer membrane efflux protein Mfla_1304 47 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91776612 Common - NAD-dependent epimerase/dehydratase Mfla_2260 126 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 91776102 Common - hypothetical protein Mfla_1749 145 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 91774789 Common - ammonium transporter Mfla_0434 203 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 91774422 Common nusA transcription elongation factor NusA Mfla_0066 218 COG0195 NusA, Transcription elongation factor Transcription 91774466 Common - hypothetical protein Mfla_0110 37 COG2501 COG2501, Uncharacterized conserved protein Function unknown 91775248 Common - hypothetical protein Mfla_0895 29 COG4104 COG4104, Uncharacterized conserved protein Function unknown 91776639 Common - hypothetical protein Mfla_2287 11 None None None 91776534 Common - RNA methyltransferase TrmH, group 2 Mfla_2182 157 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 91775900 Common - TonB-dependent receptor Mfla_1547 113 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 91776981 Common - DoxX Mfla_2633 46 COG2259 COG2259, Predicted membrane protein Function unknown 91774429 Common - Methenyltetrahydrofolate cyclohydrolase Mfla_0073 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 91776433 Common - Biotin--acetyl-CoA-carboxylase ligase Mfla_2081 218 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 91775599 Common - CheA signal transduction histidine kinases Mfla_1246 223 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 91774798 Common - putative PAS/PAC sensor protein Mfla_0443 75 None None None 91775650 Nonpathogen - hypothetical protein Mfla_1297 1 None None None 91776671 Common - Rhodanese-like protein Mfla_2319 112 COG1054 COG1054, Predicted sulfurtransferase General function prediction only 91775642 Common - major facilitator superfamily MFS_1 Mfla_1289 74 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 91775432 Common - outer membrane efflux protein Mfla_1079 20 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91775175 Nonpathogen - hypothetical protein Mfla_0822 1 None None None 91776844 Common - Peptidoglycan glycosyltransferase Mfla_2494 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 91774521 Common - putative SAM-dependent methyltransferase Mfla_0165 30 COG3129 COG3129, Predicted SAM-dependent methyltransferase General function prediction only 91774392 Common - transcriptional regulator, LytR/AlgR family Mfla_0036 213 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 91775645 Common - cytochrome C oxidase subunit IV Mfla_1292 61 COG3125 CyoD, Heme/copper-type cytochrome/quinol oxidase, subunit 4 Energy production and conversion 91775252 Common - sigma54 specific transcriptional regulator with GAF sensor, Fis family Mfla_0899 177 COG3284 AcoR, Transcriptional activator of acetoin/glycerol metabolism Secondary metabolites biosynthesis, transport, and catabolism / Transcription 91775892 Common - extracellular solute-binding protein, family 5 Mfla_1539 161 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 91776222 Common - N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase Mfla_1870 221 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 91774439 Nonpathogen - hypothetical protein Mfla_0083 3 None None None 91775477 Common - cell divisionFtsK/SpoIIIE Mfla_1124 198 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 91776656 Common - 40-residue YVTN beta-propeller repeat Mfla_2304 108 COG3391 COG3391, Uncharacterized conserved protein Function unknown 91775457 Common - Dihydroxyacetone kinase DhaK, subunit 1 Mfla_1104 77 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 91775834 Common - Hydroxyacylglutathione hydrolase Mfla_1481 205 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 91775304 Common - Lipocalin-like protein Mfla_0951 67 COG3040 Blc, Bacterial lipocalin Cell envelope biogenesis, outer membrane 91774505 Common - hypothetical protein Mfla_0149 29 COG3296 COG3296, Uncharacterized protein conserved in bacteria Function unknown 91774741 Common - diguanylate phosphodiesterase (EAL domain) Mfla_0385 41 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 91776729 Common - phospholipase D/Transphosphatidylase Mfla_2379 147 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 91774415 Common - protein of unknown function DUF583 Mfla_0059 34 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 91776095 Nonpathogen - hypothetical protein Mfla_1742 1 None None None 91776443 Common - Biopolymer transport protein ExbD/TolR Mfla_2091 36 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 91775084 Common - protein of unknown function DUF214 Mfla_0731 115 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 91777042 Nonpathogen - hypothetical protein Mfla_2694 3 None None None 91775860 Common - 3-oxoacyl-(acyl carrier protein) synthase III Mfla_1507 224 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 91774504 Common - Phosphoenolpyruvate-protein phosphotransferase Mfla_0148 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 91775797 Common - protein of unknown function DUF336 Mfla_1444 76 COG3193 GlcG, Uncharacterized protein, possibly involved in utilization of glycolate and propanediol General function prediction only 91774665 Common - transcriptional regulator, TetR family Mfla_0309 104 COG1309 AcrR, Transcriptional regulator Transcription 91775610 Common - DEAD/DEAH box helicase-like protein Mfla_1257 237 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 91777092 Common - F0F1 ATP synthase subunit beta Mfla_2744 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 91776617 Common - cell division protein FtsQ Mfla_2265 78 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 91776719 Nonpathogen - hypothetical protein Mfla_2367 1 None None None 91776468 Common - glutathione S-transferase-like protein Mfla_2116 94 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 91775994 Common - pilus assembly protein CpaE Mfla_1641 47 COG4963 CpaE, Flp pilus assembly protein, ATPase CpaE Intracellular trafficking and secretion 91776049 Common - acetyl-CoA carboxylase, carboxyl transferase, beta subunit Mfla_1696 219 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 91774480 Common - protein of unknown function DUF710 Mfla_0124 49 COG3027 COG3027, Uncharacterized protein conserved in bacteria Function unknown 91774489 Common - hypothetical protein Mfla_0133 72 COG2924 COG2924, Uncharacterized protein conserved in bacteria Function unknown 91774650 Common - ribosomal protein L6 Mfla_0294 223 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 91776216 Common - TfoX-like protein Mfla_1864 32 COG3070 TfoX, Regulator of competence-specific genes Transcription 91774764 Common - cation efflux protein Mfla_0409 114 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 91776962 Common - hypothetical protein Mfla_2613 16 None None None 91774706 Common - helix-turn-helix, Fis-type Mfla_0350 99 COG2901 Fis, Factor for inversion stimulation Fis, transcriptional activator Transcription / DNA replication, recombination, and repair 91776277 Common - phosphoglucomutase Mfla_1925 212 COG0033 Pgm, Phosphoglucomutase Carbohydrate transport and metabolism 91776319 Common - flagellar biosynthetic protein FliQ Mfla_1967 128 COG1987 FliQ, Flagellar biosynthesis pathway, component FliQ Cell motility and secretion / Intracellular trafficking and secretion 91774483 Common - ferric uptake regulator, FUR family Mfla_0127 171 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 91776621 Common - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Mfla_2269 207 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 91774777 Common - hypothetical protein Mfla_0422 19 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 91776379 Common - hypothetical protein Mfla_2027 30 None None None 91775447 Nonpathogen - transport-associated Mfla_1094 6 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 91776120 Common ureC urease subunit alpha Mfla_1767 96 COG0804 UreC, Urea amidohydrolase (urease) alpha subunit Amino acid transport and metabolism 91775450 Common - ATP-dependent DNA helicase RecQ Mfla_1097 226 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 91775574 Common - crcB protein Mfla_1221 188 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 91775262 Nonpathogen - hypothetical protein Mfla_0909 1 None None None 91776354 Common - translation initiation factor IF-3 Mfla_2002 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 91775466 Common - protein of unknown function DUF344 Mfla_1113 127 COG2326 COG2326, Uncharacterized conserved protein Function unknown 91776906 Common - RND multidrug efflux transporter MexB Mfla_2556 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 91776850 Common - lipoate-protein ligase B Mfla_2500 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 91776150 Common - Twin-arginine translocation pathway signal Mfla_1798 167 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 91775889 Common - Haloacid dehalogenase-like hydrolase Mfla_1536 153 COG0546 Gph, Predicted phosphatases General function prediction only 91776235 Common - iron permease FTR1 Mfla_1883 63 COG0672 FTR1, High-affinity Fe2+/Pb2+ permease Inorganic ion transport and metabolism 91776883 Common - acriflavin resistance protein Mfla_2533 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 91776503 Common - 4-hydroxythreonine-4-phosphate dehydrogenase Mfla_2151 159 COG1995 PdxA, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 91776281 Common - response regulator receiver domain protein (CheY-like) Mfla_1929 219 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 91774368 Common - hypothetical protein Mfla_0012 15 None None None 91776840 Common gatC aspartyl/glutamyl-tRNA amidotransferase subunit C Mfla_2490 146 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 91774659 Common - 30S ribosomal protein S11 Mfla_0303 248 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 91775814 Nonpathogen - hypothetical protein Mfla_1461 1 None None None 91776062 Common - ornithine carbamoyltransferase Mfla_1709 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 91774573 Common - RNA polymerase factor sigma-70 Mfla_0217 33 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 91775471 Common - Smr protein/MutS2 Mfla_1118 98 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 91776322 Common - Flagellar motor switch FliN Mfla_1970 123 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 91774613 Common - histidine triad (HIT) protein Mfla_0257 233 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 91774396 Common - Putative oxygen-independent coproporphyrinogen III oxidase Mfla_0040 206 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 91774993 Common - BFD-like (2Fe-2S)-binding region Mfla_0638 35 COG2906 Bfd, Bacterioferritin-associated ferredoxin Inorganic ion transport and metabolism 91774821 Nonpathogen - hypothetical protein Mfla_0466 1 None None None 91776052 Common - Phosphoribosylanthranilate isomerase Mfla_1699 192 COG0135 TrpF, Phosphoribosylanthranilate isomerase Amino acid transport and metabolism 91776876 Common - AsmA Mfla_2526 66 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 91777006 Common - membrane protein involved in aromatic hydrocarbon degradation Mfla_2658 82 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 91775617 Common - ATP-dependent protease-like protein Mfla_1264 90 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 91776799 Common - signal transduction histidine kinase, nitrogen specific, NtrB Mfla_2449 170 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 91775602 Common - tRNA(Ile)-lysidine synthetase-like protein Mfla_1249 191 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 91776683 Common rplS 50S ribosomal protein L19 Mfla_2331 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 91776666 Common - Pyrrolo-quinoline quinone Mfla_2314 60 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 91775745 Common - Molybdate ABC transporter, permease protein Mfla_1392 212 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 91776548 Common - cytochrome c, class I Mfla_2196 28 COG4654 COG4654, Cytochrome c551/c552 Energy production and conversion 91774541 Common - heat shock protein HtpX Mfla_0185 190 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 91775577 Common nrdB ribonucleotide-diphosphate reductase subunit beta Mfla_1224 151 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 91775739 Common - hypothetical protein Mfla_1386 240 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 91776690 Common - OmpA/MotB Mfla_2338 143 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 91774531 Common - MgtC/SapB transporter Mfla_0175 106 COG1285 SapB, Uncharacterized membrane protein Function unknown 91775218 Common - palmitoyl transferase for Lipid A Mfla_0865 14 None None None 91774380 Common - acetyl-CoA carboxylase, biotin carboxylase Mfla_0024 234 COG0439 AccC, Biotin carboxylase Lipid metabolism 91775729 Common - GtrA-like protein Mfla_1376 7 COG2246 COG2246, Predicted membrane protein Function unknown 91775211 Common - sigma E regulatory protein, MucB/RseB Mfla_0858 48 COG3026 RseB, Negative regulator of sigma E activity Signal transduction mechanisms 91775070 Common - hypothetical protein Mfla_0717 12 COG3678 CpxP, P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism 91777049 Common - Mu-like prophage FluMu protein gp28-like Mfla_2701 24 COG4373 COG4373, Mu-like prophage FluMu protein gp28 General function prediction only 91776516 Common - biotin synthase Mfla_2164 177 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 91775486 Common - protein of unknown function DUF6, transmembrane Mfla_1133 127 COG2962 RarD, Predicted permeases General function prediction only 91774806 Common - Alkaline phosphatase Mfla_0451 83 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 91775018 Common - phospholipase D/Transphosphatidylase Mfla_0663 144 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 91776252 Common - von Willebrand factor, type A Mfla_1900 9 None None None 91774734 Common - D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase Mfla_0378 107 COG2027 DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) Cell envelope biogenesis, outer membrane 91775391 Common - hypothetical protein Mfla_1038 4 None None None 91776969 Common - (2Fe-2S)-binding Mfla_2620 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 91774761 Common - hypothetical protein Mfla_0406 14 None None None 91774889 Nonpathogen - hypothetical protein Mfla_0534 1 None None None 91774700 Common - Pyrrolo-quinoline quinone Mfla_0344 60 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 91774409 Common - Chorismate lyase Mfla_0053 33 COG3161 UbiC, 4-hydroxybenzoate synthetase (chorismate lyase) Coenzyme metabolism 91774879 Common - GCN5-related N-acetyltransferase Mfla_0524 21 None None None 91775733 Common - protein of unknown function UPF0079 Mfla_1380 200 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 91775875 Common - surface antigen (D15) Mfla_1522 160 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 91775975 Common - Tetratricopeptide TPR_2 Mfla_1622 126 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 91777026 Common - hypothetical protein Mfla_2678 5 None None None 91774805 Common - multiple drug resistance protein MarC Mfla_0450 143 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 91776898 Common - Integrase, catalytic region Mfla_2548 73 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 91777015 Common - hypothetical protein Mfla_2667 49 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 91776953 Common - restriction endonuclease Mfla_2603 26 COG4127 COG4127, Uncharacterized conserved protein Function unknown 91776834 Common - exodeoxyribonuclease III (xth) Mfla_2484 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 91775952 Common - TonB-dependent receptor, plug Mfla_1599 68 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 91775547 Common - UDP-galactopyranose mutase Mfla_1194 56 COG0562 Glf, UDP-galactopyranose mutase Cell envelope biogenesis, outer membrane 91774987 Common - cytochrome c oxidase, cbb3-type, subunit III Mfla_0632 82 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 91776926 Common - protein of unknown function DUF6, transmembrane Mfla_2576 152 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 91775811 Common - hypothetical protein Mfla_1458 5 None None None 91776668 Common - cyclic nucleotide-binding domain (cNMP-BD) protein Mfla_2316 136 COG1295 Rbn, Predicted membrane protein Function unknown 91775758 Nonpathogen - TPR repeat Mfla_1405 1 None None None 91775851 Common - type IV pilus assembly PilZ Mfla_1498 33 COG3215 PilZ, Tfp pilus assembly protein PilZ Cell motility and secretion / Intracellular trafficking and secretion 91776044 Common - O-succinylhomoserine sulfhydrylase Mfla_1691 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 91774718 Nonpathogen - hypothetical protein Mfla_0362 2 None None None 91775459 Common - ribose 5-phosphate isomerase Mfla_1106 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 91774590 Common - cytochrome c assembly protein Mfla_0234 188 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 91774447 Common valS valyl-tRNA synthetase Mfla_0091 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 91776302 Common - OmpA/MotB Mfla_1950 156 COG1360 MotB, Flagellar motor protein Cell motility and secretion 91774712 Common - protein of unknown function UPF0153 Mfla_0356 35 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 91777034 Common - hypothetical protein Mfla_2686 5 None None None 91774674 Common - Nitrite reductase (NAD(P)H) large subunit, NirD Mfla_0318 51 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 91774373 Common - hypothetical protein Mfla_0017 9 None None None 91774937 Common - putative monovalent cation/H+ antiporter subunit A Mfla_0582 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 91775295 Common - cytochrome d ubiquinol oxidase, subunit II Mfla_0942 155 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 91775381 Common - hypothetical protein Mfla_1028 7 None None None 91775938 Common - hypothetical protein Mfla_1585 29 COG3242 COG3242, Uncharacterized protein conserved in bacteria Function unknown 91775693 Common - hypothetical protein Mfla_1340 6 None None None 91775356 Common - Peptidase S1C, Do Mfla_1003 224 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 91776917 Common - secretion protein HlyD Mfla_2567 168 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 91775540 Nonpathogen - hypothetical protein Mfla_1187 1 None None None 91776722 Common - transcriptional regulator, AraC family Mfla_2370 99 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 91776914 Common - transcriptional regulator, TetR family Mfla_2564 52 COG1309 AcrR, Transcriptional regulator Transcription 91776822 Common - Ribulose-phosphate 3-epimerase Mfla_2472 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 91774904 Common - methylamine utilisation MauE Mfla_0549 8 None None None 91776755 Common - Filamentous haemagglutinin-like protein Mfla_2405 97 None None None 91776263 Common - CTP synthetase Mfla_1911 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 91776496 Common - Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family Mfla_2144 136 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 91776571 Common - ribosomal protein L21 Mfla_2219 215 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 91775921 Common - hypothetical protein Mfla_1568 7 None None None 91776862 Common - hypothetical protein Mfla_2512 37 None None None 91775082 Common - Oxidoreductase FAD-binding region Mfla_0729 104 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 91776460 Common - Protein of unknown function UPF0001 Mfla_2108 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 91774983 Common - electron transport protein SCO1/SenC Mfla_0628 104 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 91776812 Common - Penicillin-binding protein 1A Mfla_2462 202 COG5009 MrcA, Membrane carboxypeptidase/penicillin-binding protein Cell envelope biogenesis, outer membrane 91775707 Common - Succinylglutamate desuccinylase/aspartoacylase Mfla_1354 14 COG3608 COG3608, Predicted deacylase General function prediction only 91774402 Common - hypothetical protein Mfla_0046 137 COG1561 COG1561, Uncharacterized stress-induced protein Function unknown 91774922 Common - aspartate kinase Mfla_0567 236 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 91775422 Nonpathogen - hypothetical protein Mfla_1069 4 COG5416 COG5416, Uncharacterized integral membrane protein Function unknown 91774667 Common rpmG 50S ribosomal protein L33 Mfla_0311 136 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 91775564 Nonpathogen - hypothetical protein Mfla_1211 1 None None None 91775128 Common - DNA repair protein RecN Mfla_0775 207 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 91775996 Common - Flp pilus assembly CpaB Mfla_1643 50 COG3745 CpaB, Flp pilus assembly protein CpaB Intracellular trafficking and secretion 91775750 Common - putative phospholipase Mfla_1397 52 COG2829 PldA, Outer membrane phospholipase A Cell envelope biogenesis, outer membrane 91775142 Common - hypothetical protein Mfla_0789 12 None None None 91776738 Common - extracellular solute-binding protein, family 5 Mfla_2388 186 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 91774882 Common - hypothetical protein Mfla_0527 18 COG3137 COG3137, Putative salt-induced outer membrane protein Cell envelope biogenesis, outer membrane 91775856 Common - beta-ketoacyl synthase Mfla_1503 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 91776034 Common - coenzyme PQQ synthesis D Mfla_1681 11 None None None 91776632 Common - dihydroorotase Mfla_2280 91 COG0418 PyrC, Dihydroorotase Nucleotide transport and metabolism 91776426 Common aceE pyruvate dehydrogenase subunit E1 Mfla_2074 161 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 91775661 Common - periplasmic sensor signal transduction histidine kinase Mfla_1308 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 91774845 Common - major facilitator superfamily MFS_1 Mfla_0490 77 None None None 91775041 Common - hypothetical protein Mfla_0688 28 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 91774688 Common - ABC transporter, ATP-binding/permease protein Mfla_0332 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 91776582 Common - hypothetical protein Mfla_2230 184 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 91774866 Common secF preprotein translocase subunit SecF Mfla_0511 206 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 91775048 Common - Na+/solute symporter Mfla_0695 176 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 91775335 Common - Cupin 4 Mfla_0982 58 COG2850 COG2850, Uncharacterized conserved protein Function unknown 91775887 Common - Alkanesulfonate monooxygenase Mfla_1534 69 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 91774697 Common - Aldose 1-epimerase Mfla_0341 65 COG0676 COG0676, Uncharacterized enzymes related to aldose 1-epimerase Carbohydrate transport and metabolism 91774857 Common - outer membrane efflux protein Mfla_0502 92 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91774822 Common apaH diadenosine tetraphosphatase Mfla_0467 103 COG0639 ApaH, Diadenosine tetraphosphatase and related serine/threonine protein phosphatases Signal transduction mechanisms 91775003 Common - CBS Mfla_0648 218 COG4535 CorC, Putative Mg2+ and Co2+ transporter CorC Inorganic ion transport and metabolism 91776453 Common - phosphoribosyltransferase Mfla_2101 109 COG2065 PyrR, Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase Nucleotide transport and metabolism 91776182 Common - NADH:flavin oxidoreductase/NADH oxidase Mfla_1830 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 91774417 Common - Citrate synthase I Mfla_0061 193 COG0372 GltA, Citrate synthase Energy production and conversion 91776078 Common - metal dependent phosphohydrolase Mfla_1725 124 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 91776162 Common - protein of unknown function DUF395, YeeE/YedE Mfla_1810 65 COG2391 COG2391, Predicted transporter component General function prediction only 91775443 Nonpathogen - hypothetical protein Mfla_1090 1 None None None 91776910 Common - ABC transporter related Mfla_2560 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 91775032 Common - 4-diphosphocytidyl-2C-methyl-D-erythritol kinase Mfla_0679 185 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 91776762 Common - methylation Mfla_2412 13 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 91775675 Common - Pseudouridine synthase, RluD Mfla_1322 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 91776194 Common - Rhomboid-like protein Mfla_1842 113 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 91775022 Common - GAF sensor hybrid histidine kinase Mfla_0667 224 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 91775515 Common - hypothetical protein Mfla_1162 4 None None None 91776784 Common - formyltetrahydrofolate deformylase Mfla_2434 218 COG0788 PurU, Formyltetrahydrofolate hydrolase Nucleotide transport and metabolism 91776805 Common - 3-dehydroquinate synthase Mfla_2455 215 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 91776558 Common - Alcohol dehydrogenase, zinc-binding Mfla_2206 184 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 91774709 Common - protein of unknown function DUF72 Mfla_0353 108 COG1801 COG1801, Uncharacterized conserved protein Function unknown 91775029 Common - peptidyl-tRNA hydrolase Mfla_0676 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 91775246 Common - putative phosphoketolase Mfla_0893 65 COG3957 COG3957, Phosphoketolase Carbohydrate transport and metabolism 91774450 Common - Rhodanese-like protein Mfla_0094 135 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 91775187 Common - DNA mismatch repair protein MutS Mfla_0834 203 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 91775412 Common - Lysine decarboxylase Mfla_1059 86 COG1982 LdcC, Arginine/lysine/ornithine decarboxylases Amino acid transport and metabolism 91776484 Common - Polyprenyl synthetase Mfla_2132 239 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 91776380 Common - sugar transferase Mfla_2028 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 91776473 Common - ketol-acid reductoisomerase Mfla_2121 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 91777057 Nonpathogen - hypothetical protein Mfla_2709 1 None None None 91775804 Common - Pyrrolo-quinoline quinone Mfla_1451 68 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 91775159 Common - iron-sulfur cluster assembly protein IscA Mfla_0806 164 COG0316 IscA, Uncharacterized conserved protein Function unknown 91775282 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Mfla_0929 229 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 91776261 Common eno phosphopyruvate hydratase Mfla_1909 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 91776973 Common - hypothetical protein Mfla_2624 31 COG3593 COG3593, Predicted ATP-dependent endonuclease of the OLD family DNA replication, recombination, and repair 91776936 Common - hypothetical protein Mfla_2586 8 None None None 91775497 Common - cyclase/dehydrase Mfla_1144 102 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 91777050 Common - hypothetical protein Mfla_2702 13 None None None 91775823 Common - amine oxidase Mfla_1470 69 COG2907 COG2907, Predicted NAD/FAD-binding protein General function prediction only 91775530 Common - transcriptional regulator, XRE family Mfla_1177 159 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 91776742 Common - OmpA/MotB Mfla_2392 112 COG1360 MotB, Flagellar motor protein Cell motility and secretion 91775983 Common - outer membrane efflux protein Mfla_1630 58 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91775199 Common - HAD-superfamily subfamily IIA hydrolase, hypothetical 2 Mfla_0846 103 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 91776296 Common - flagellar biosynthetic protein FlhB Mfla_1944 130 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 91776317 Common - diguanylate phosphodiesterase (EAL domain) Mfla_1965 44 COG3434 COG3434, Predicted signal transduction protein containing EAL and modified HD-GYP domains Signal transduction mechanisms 91774445 Common - LemA Mfla_0089 131 COG1704 LemA, Uncharacterized conserved protein Function unknown 91776567 Common - phosphoribosylaminoimidazole carboxylase, catalytic subunit Mfla_2215 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 91775525 Common - phage transcriptional regulator, AlpA Mfla_1172 23 COG3311 AlpA, Predicted transcriptional regulator Transcription 91774927 Common - phosphatidylglycerophosphatase A Mfla_0572 87 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 91775427 Common - Prephenate dehydrogenase Mfla_1074 171 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 91775149 Common - peptide chain release factor 2 Mfla_0796 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 91776068 Common - multi-sensor signal transduction histidine kinase Mfla_1715 187 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 91774523 Common - response regulator receiver domain protein (CheY-like) Mfla_0167 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 91774796 Common - ferredoxin Mfla_0441 105 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 91775162 Common - aminotransferase, class V Mfla_0809 238 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 91776003 Common - protein of unknown function DUF201 Mfla_1650 23 COG1821 COG1821, Predicted ATP-utilizing enzyme (ATP-grasp superfamily) General function prediction only 91775173 Nonpathogen - hypothetical protein Mfla_0820 1 None None None 91776360 Common - dTDP-glucose 4,6-dehydratase Mfla_2008 232 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 91776998 Common - glycosyl transferase, family 2 Mfla_2650 117 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 91777014 Common - uroporphyrinogen decarboxylase Mfla_2666 182 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 91776083 Common - transcriptional regulator Mfla_1730 10 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 91774978 Common - hypothetical protein Mfla_0623 131 COG2096 COG2096, Uncharacterized conserved protein Function unknown 91774698 Common - cytochrome c, class I Mfla_0342 26 COG4654 COG4654, Cytochrome c551/c552 Energy production and conversion 91775777 Common - hypothetical protein Mfla_1424 9 None None None 91776241 Common - succinyl-CoA synthetase, beta subunit Mfla_1889 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 91774936 Common - putative monovalent cation/H+ antiporter subunit C Mfla_0581 99 COG1006 MnhC, Multisubunit Na+/H+ antiporter, MnhC subunit Inorganic ion transport and metabolism 91776849 Common - protein of unknown function DUF493 Mfla_2499 51 COG2921 COG2921, Uncharacterized conserved protein Function unknown 91775620 Common - short-chain dehydrogenase/reductase SDR Mfla_1267 234 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 91776211 Common - ABC transport system substrate-binding protein Mfla_1859 65 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 91774930 Nonpathogen - hypothetical protein Mfla_0575 4 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 91774953 Common - deoxynucleoside kinase Mfla_0598 39 COG1428 COG1428, Deoxynucleoside kinases Nucleotide transport and metabolism 91776188 Nonpathogen - hypothetical protein Mfla_1836 5 None None None 91776747 Nonpathogen - hypothetical protein Mfla_2397 2 None None None 91776070 Common - Pyrrolo-quinoline quinone Mfla_1717 60 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 91776908 Common - transcriptional regulator, IclR family Mfla_2558 104 COG1414 IclR, Transcriptional regulator Transcription 91775327 Nonpathogen - hypothetical protein Mfla_0974 1 None None None 91774835 Common - putative transmembrane protein Mfla_0480 3 None None None 91775108 Common - lipopolysaccharide kinase Mfla_0755 10 None None None 91776369 Common - glycosyl transferase, family 2 Mfla_2017 170 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 91776901 Common - Heavy metal efflux pump CzcA Mfla_2551 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 91774755 Common - D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding Mfla_0399 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 91775360 Common - Ribonuclease III Mfla_1007 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 91774583 Common - DNA topoisomerase Mfla_0227 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 91776513 Common - Biotin biosynthesis protein BioC Mfla_2161 149 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 91775844 Common - arsenite-activated ATPase (arsA) Mfla_1491 92 COG0003 ArsA, Predicted ATPase involved in chromosome partitioning Cell division and chromosome partitioning 91776599 Common pgk phosphoglycerate kinase Mfla_2247 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 91774367 Common - malate:quinone oxidoreductase Mfla_0011 55 COG0579 COG0579, Predicted dehydrogenase General function prediction only 91776885 Common - isochorismatase hydrolase Mfla_2535 62 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 91775490 Common - GreA/GreB family elongation factor Mfla_1137 171 COG0782 GreA, Transcription elongation factor Transcription 91776870 Common - hypothetical protein Mfla_2520 11 COG4966 PilW, Tfp pilus assembly protein PilW Cell motility and secretion / Intracellular trafficking and secretion 91776695 Common - 4-hydroxybenzoyl-CoA thioesterase Mfla_2343 150 COG0824 FcbC, Predicted thioesterase General function prediction only 91775205 Common - hypothetical protein Mfla_0852 10 COG4398 COG4398, Uncharacterized protein conserved in bacteria Function unknown 91776853 Common - Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family Mfla_2503 132 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 91777071 Common - hypothetical protein Mfla_2723 6 None None None 91775101 Common - 2-isopropylmalate synthase Mfla_0748 211 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 91775119 Nonpathogen - hypothetical protein Mfla_0766 1 None None None 91774598 Common - ABC transporter related Mfla_0242 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 91776543 Common - hypothetical protein Mfla_2191 7 None None None 91776877 Common - undecaprenol kinase, putative Mfla_2527 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 91777087 Common - two component transcriptional regulator, winged helix family Mfla_2739 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 91775816 Nonpathogen - hypothetical protein Mfla_1463 1 None None None 91776501 Common - Organic solvent tolerance protein Mfla_2149 115 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 91777105 Common - tRNA modification GTPase TrmE Mfla_2757 223 COG0486 ThdF, Predicted GTPase General function prediction only 91774991 Common - bacterioferritin Mfla_0636 105 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 91776156 Common - excinuclease ABC, C subunit Mfla_1804 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 91775315 Common - ribose 5-phosphate isomerase Mfla_0962 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 91774740 Common - SelT/selW/selH selenoprotein Mfla_0384 32 COG3526 COG3526, Uncharacterized protein conserved in bacteria Posttranslational modification, protein turnover, chaperones 91776065 Common - protein of unknown function DUF6, transmembrane Mfla_1712 134 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 91774998 Common - D,D-heptose 1,7-bisphosphate phosphatase Mfla_0643 130 COG0241 HisB, Histidinol phosphatase and related phosphatases Amino acid transport and metabolism 91776950 Nonpathogen - hypothetical protein Mfla_2600 12 None None None 91775155 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) Mfla_0802 197 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 91775819 Common def peptide deformylase Mfla_1466 214 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 91776680 Common - dihydroneopterin aldolase Mfla_2328 106 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 91776694 Common - MotA/TolQ/ExbB proton channel Mfla_2342 145 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 91776583 Common - protein of unknown function DUF815 Mfla_2231 89 COG2607 COG2607, Predicted ATPase (AAA+ superfamily) General function prediction only 91774570 Common - two component, sigma54 specific, transcriptional regulator, Fis family Mfla_0214 220 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 91775913 Common - TonB-like protein Mfla_1560 47 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 91775092 Common - Glyoxalase I Mfla_0739 135 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 91774630 Common rpsL 30S ribosomal protein S12 Mfla_0274 238 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 91777088 Nonpathogen - hypothetical protein Mfla_2740 1 None None None 91775242 Common - L-sorbosone dehydrogenase, putative Mfla_0889 119 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 91776339 Common - two component transcriptional regulator, LuxR family Mfla_1987 221 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 91774615 Common - twin-arginine translocation protein TatB Mfla_0259 34 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 91777081 Common - flavodoxin/nitric oxide synthase Mfla_2733 106 COG0369 CysJ, Sulfite reductase, alpha subunit (flavoprotein) Inorganic ion transport and metabolism 91776505 Common - adenylate kinases Mfla_2153 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 91775788 Nonpathogen - hypothetical protein Mfla_1435 1 None None None 91777047 Nonpathogen - hypothetical protein Mfla_2699 1 None None None 91774725 Common - NADH:flavin oxidoreductase/NADH oxidase Mfla_0369 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 91775137 Common - dihydropteroate synthase Mfla_0784 218 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 91776750 Common - hypothetical protein Mfla_2400 16 None None None 91776020 Common - protein of unknown function UPF0029 Mfla_1667 130 COG1739 COG1739, Uncharacterized conserved protein Function unknown 91777076 Common - protein of unknown function DUF1018 Mfla_2728 21 COG4382 COG4382, Mu-like prophage protein gp16 Function unknown 91775997 Common - TadE-like protein Mfla_1644 6 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 91776759 Common - transcriptional regulator, LuxR family Mfla_2409 132 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 91775800 Common - cytochrome c oxidase, subunit III Mfla_1447 124 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 91775600 Common - DNA polymerase III, alpha subunit Mfla_1247 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 91775810 Common - type II and III secretion system protein Mfla_1457 108 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 91774386 Common - FxsA cytoplasmic membrane protein Mfla_0030 40 COG3030 FxsA, Protein affecting phage T7 exclusion by the F plasmid General function prediction only 91775870 Common - lipid-A-disaccharide synthase Mfla_1517 139 COG0763 LpxB, Lipid A disaccharide synthetase Cell envelope biogenesis, outer membrane 91775830 Common - 6-pyruvoyl tetrahydrobiopterin synthase Mfla_1477 103 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 91776367 Common - glycosyl transferase, group 1 Mfla_2015 194 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 91775196 Common - dihydrodipicolinate synthase Mfla_0843 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 91776320 Common fliP flagellar biosynthesis protein FliP Mfla_1968 128 COG1338 FliP, Flagellar biosynthesis pathway, component FliP Cell motility and secretion / Intracellular trafficking and secretion 91774493 Common - KpsF/GutQ family protein Mfla_0137 155 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 91775309 Common - hypothetical protein Mfla_0956 8 None None None 91775230 Common - MotA/TolQ/ExbB proton channel Mfla_0877 147 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 91774691 Nonpathogen - hypothetical protein Mfla_0335 2 None None None 91776409 Common - NADH-quinone oxidoreductase, E subunit Mfla_2057 155 COG1905 NuoE, NADH:ubiquinone oxidoreductase 24 kD subunit Energy production and conversion 91774767 Common - peptidase M22, glycoprotease Mfla_0412 191 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 91775470 Common - 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Mfla_1117 189 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 91774928 Common - thiamine-monophosphate kinase Mfla_0573 191 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 91775799 Nonpathogen - hypothetical protein Mfla_1446 1 None None None 91776328 Common - flagellar assembly protein FliH Mfla_1976 52 COG1317 FliH, Flagellar biosynthesis/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 91775837 Common - binding-protein-dependent transport systems inner membrane component Mfla_1484 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 91776144 Common - secretion protein HlyD Mfla_1792 158 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 91776342 Common - putative regulatory lipoprotein Mfla_1990 74 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 91774894 Common - translation initiation factor IF-1 Mfla_0539 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 91776718 Common - ABC transporter related Mfla_2366 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 91776482 Common - Carboxylesterase Mfla_2130 96 COG0400 COG0400, Predicted esterase General function prediction only 91776590 Common - ABC transporter related Mfla_2238 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 91774844 Common - two component transcriptional regulator, winged helix family Mfla_0489 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 91775501 Common - short-chain dehydrogenase/reductase SDR Mfla_1148 205 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 91776234 Common - peptidase M61 Mfla_1882 57 COG3975 COG3975, Predicted protease with the C-terminal PDZ domain General function prediction only 91776176 Common surE stationary phase survival protein SurE Mfla_1824 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 91776259 Common - diguanylate cyclase (GGDEF domain) Mfla_1907 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 91776408 Common - NADH-quinone oxidoreductase, F subunit Mfla_2056 168 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 91774747 Common - protein of unknown function DUF404 Mfla_0391 89 COG2308 COG2308, Uncharacterized conserved protein Function unknown 91776109 Nonpathogen - hypothetical protein Mfla_1756 2 None None None 91775612 Common - GTP-binding protein TypA Mfla_1259 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 91774780 Common - hypothetical protein Mfla_0425 25 COG3656 COG3656, Predicted periplasmic protein Function unknown 91776462 Common - protein of unknown function YGGT Mfla_2110 31 None None None 91776128 Common - Twin-arginine translocation pathway signal Mfla_1775 140 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 91775239 Common - diguanylate cyclase (GGDEF domain) Mfla_0886 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 91774476 Common - cob(I)alamin adenosyltransferase Mfla_0120 141 COG2109 BtuR, ATP:corrinoid adenosyltransferase Coenzyme metabolism 91777025 Common - hypothetical protein Mfla_2677 12 None None None 91775268 Common - Lysine decarboxylase Mfla_0915 86 COG1982 LdcC, Arginine/lysine/ornithine decarboxylases Amino acid transport and metabolism 91775438 Common - GCN5-related N-acetyltransferase Mfla_1085 110 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 91774666 Common - conserved hypothetical signal peptide protein Mfla_0310 13 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 91775633 Common - phosphoribosyltransferase Mfla_1280 151 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 91774890 Common - NHL repeat Mfla_0535 83 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 91776610 Common - hypothetical protein Mfla_2258 62 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 91774571 Common - periplasmic sensor signal transduction histidine kinase Mfla_0215 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 91774957 Common - CRISPR-associated protein, CT1134 Mfla_0602 38 None None None 91776739 Common - binding-protein-dependent transport systems inner membrane component Mfla_2389 217 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 91774701 Common - amino acid permease-associated region Mfla_0345 163 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 91774657 Common - ribosomal protein L36 Mfla_0301 34 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 91775644 Common - protoheme IX farnesyltransferase Mfla_1291 170 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 91777064 Common - hypothetical protein Mfla_2716 11 None None None 91776180 Common - thioredoxin-related Mfla_1828 217 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 91776170 Nonpathogen - hypothetical protein Mfla_1818 1 None None None 91774584 Common - PP-loop Mfla_0228 167 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 91774962 Common - protein of unknown function DUF196 Mfla_0607 48 COG1343 COG1343, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 91775169 Common - two component transcriptional regulator, LuxR family Mfla_0816 216 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 91776352 Common rplT 50S ribosomal protein L20 Mfla_2000 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 91776720 Common - Mammalian cell entry related Mfla_2368 80 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 91774626 Common rplJ 50S ribosomal protein L10 Mfla_0270 211 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 91776098 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Mfla_1745 201 COG0388 COG0388, Predicted amidohydrolase General function prediction only 91774644 Common - ribosomal protein S17 Mfla_0288 225 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 91774459 Common - cobyric acid synthase Mfla_0103 158 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 91774529 Common - nitroreductase Mfla_0173 76 COG0778 NfnB, Nitroreductase Energy production and conversion 91775869 Common - Ribonuclease H Mfla_1516 231 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 91776228 Common - Sua5/YciO/YrdC/YwlC Mfla_1876 228 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 91776761 Common - hypothetical protein Mfla_2411 11 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 91776042 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Mfla_1689 224 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 91776984 Common apaG ApaG Mfla_2636 89 COG2967 ApaG, Uncharacterized protein affecting Mg2+/Co2+ transport Inorganic ion transport and metabolism 91776195 Common - protein of unknown function UPF0005 Mfla_1843 58 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 91775959 Common - transport system permease protein Mfla_1606 192 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 91776971 Common - major facilitator superfamily MFS_1 Mfla_2622 140 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 91776642 Common rho transcription termination factor Rho Mfla_2290 223 COG1158 Rho, Transcription termination factor Transcription 91776790 Common - ABC transporter related Mfla_2440 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 91775537 Common - histidine kinase Mfla_1184 215 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 91776272 Common - protein of unknown function DUF528 Mfla_1920 43 COG2975 COG2975, Uncharacterized protein conserved in bacteria Function unknown 91775418 Common metG methionyl-tRNA synthetase Mfla_1065 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 91775647 Common - Cytochrome-c oxidase Mfla_1294 166 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 91776474 Common - Phosphatidylserine decarboxylase Mfla_2122 94 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 91775254 Common - 4Fe-4S ferredoxin, iron-sulfur binding Mfla_0901 78 COG0348 NapH, Polyferredoxin Energy production and conversion 91775637 Common - hypothetical protein Mfla_1284 16 COG5412 COG5412, Phage-related protein Function unknown 91774437 Nonpathogen - hypothetical protein Mfla_0081 1 None None None 91776637 Common - transport-associated Mfla_2285 55 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 91774578 Common - Leucyl aminopeptidase Mfla_0222 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 91776376 Common - Protein-tyrosine kinase Mfla_2024 118 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 91775421 Common - hypothetical protein Mfla_1068 62 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 91775281 Common - cytidylate kinase Mfla_0928 204 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 91775433 Common - Twin-arginine translocation pathway signal Mfla_1080 131 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 91775340 Common - dihydrodipicolinate synthase Mfla_0987 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 91776026 Common - sulfate adenylyltransferase subunit 2 Mfla_1673 125 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 91775053 Common - hypothetical protein Mfla_0700 40 COG1160 COG1160, Predicted GTPases General function prediction only 91775213 Common - GTP-binding protein LepA Mfla_0860 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 91774903 Common - Amine dehydrogenase Mfla_0548 11 None None None 91776207 Common - putative transcriptional regulator, CopG family Mfla_1855 65 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 91774361 Common - sulphate transporter Mfla_0005 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 91775177 Nonpathogen - hypothetical protein Mfla_0824 1 None None None 91775163 Common - transcriptional regulator, BadM/Rrf2 family Mfla_0810 176 COG1959 COG1959, Predicted transcriptional regulator Transcription 91774607 Common - Imidazoleglycerol-phosphate dehydratase Mfla_0251 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 91776653 Common - TonB-dependent receptor Mfla_2301 126 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 91774560 Common - Chromosomal replication initiator, DnaA Mfla_0204 174 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 91775368 Nonpathogen - hypothetical protein Mfla_1015 4 None None None 91774944 Common - short-chain dehydrogenase/reductase SDR Mfla_0589 234 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 91776615 Common - cell division protein FtsZ Mfla_2263 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 91777058 Common - transcriptional regulator, XRE family Mfla_2710 23 COG1813 COG1813, Predicted transcription factor, homolog of eukaryotic MBF1 Transcription 91777040 Common - hypothetical protein Mfla_2692 9 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 91776054 Common - hypothetical protein Mfla_1701 39 COG3170 FimV, Tfp pilus assembly protein FimV Cell motility and secretion / Intracellular trafficking and secretion 91777008 Common - UspA Mfla_2660 6 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 91775491 Common - tryptophanyl-tRNA synthetase II Mfla_1138 238 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 91775897 Common - luciferase-like protein Mfla_1544 72 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 91775549 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Mfla_1196 249 COG3634 AhpF, Alkyl hydroperoxide reductase, large subunit Posttranslational modification, protein turnover, chaperones 91775411 Common - Dihydrofolate reductase Mfla_1058 146 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 91775651 Common - (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA Mfla_1298 205 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 91777069 Common - hypothetical protein Mfla_2721 18 None None None 91775302 Common - hypothetical protein Mfla_0949 13 None None None 91774858 Common - secretion protein HlyD Mfla_0503 143 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 91775969 Common - hypothetical protein Mfla_1616 29 COG2976 COG2976, Uncharacterized protein conserved in bacteria Function unknown 91774972 Common - cysteine desulfurases, SufS subfamily Mfla_0617 239 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 91776060 Common - protein of unknown function DUF1255 Mfla_1707 53 COG3123 COG3123, Uncharacterized protein conserved in bacteria Function unknown 91776279 Common - transcriptional regulator, LuxR family Mfla_1927 111 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 91774550 Common - S-adenosylmethionine synthetase Mfla_0194 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 91775079 Common - transcriptional regulator, LysR family Mfla_0726 182 COG0583 LysR, Transcriptional regulator Transcription 91776147 Common - Lysine exporter protein (LYSE/YGGA) Mfla_1795 74 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 91776100 Nonpathogen - hypothetical protein Mfla_1747 1 None None None 91775508 Common - Recombinase Mfla_1155 141 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 91775542 Common - Glycogen debranching enzyme GlgX Mfla_1189 161 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 91775726 Common - putative beta (1-6) glucan synthase Mfla_1373 16 COG5309 COG5309, Exo-beta-1,3-glucanase Carbohydrate transport and metabolism 91776411 Common - NADH (or F420H2) dehydrogenase, subunit C Mfla_2059 172 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 91777094 Common - ATP synthase F1, alpha subunit Mfla_2746 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 91774548 Nonpathogen - membrane protein of unknown function Mfla_0192 1 COG1950 COG1950, Predicted membrane protein Function unknown 91776625 Common - UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase Mfla_2273 213 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 91774775 Common - prolyl-tRNA synthetase Mfla_0420 247 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 91776084 Common - Antibiotic biosynthesis monooxygenase Mfla_1731 29 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 91776937 Common - multi-sensor hybrid histidine kinase Mfla_2587 225 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 91775555 Common - UvrD/REP helicase Mfla_1202 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 91774426 Common - ribosomal protein S15 Mfla_0070 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 91776600 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Mfla_2248 223 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 91774519 Common - Methyltransferase type 11 Mfla_0163 60 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 91775498 Common smpB SsrA-binding protein Mfla_1145 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 91774433 Common - TPR repeat Mfla_0077 14 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 91774469 Common - cobalbumin biosynthesis enzyme Mfla_0113 129 COG2087 CobU, Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase Coenzyme metabolism 91774916 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Mfla_0561 178 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 91774562 Common - hypothetical protein Mfla_0206 14 None None None 91774731 Nonpathogen - hypothetical protein Mfla_0375 1 None None None 91774820 Common - hypothetical protein Mfla_0465 2 None None None 91774875 Common - HAD-superfamily subfamily IB, PSPase-like protein Mfla_0520 77 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 91775088 Common - peptidase M16-like protein Mfla_0735 178 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 91775945 Common - Hydrophobe/amphiphile efflux-1 HAE1 Mfla_1592 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 91776075 Common - methyltransferase small Mfla_1722 91 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 91776889 Common - Outer membrane autotransporter barrel Mfla_2539 60 COG4625 COG4625, Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain Function unknown 91774791 Nonpathogen - GCN5-related N-acetyltransferase Mfla_0436 12 COG0456 RimI, Acetyltransferases General function prediction only 91775598 Common - methyl-accepting chemotaxis sensory transducer Mfla_1245 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 91774797 Common - hypothetical protein Mfla_0442 21 None None None 91775734 Common - N-acetylmuramoyl-L-alanine amidase Mfla_1381 177 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 91774932 Common - putative monovalent cation/H+ antiporter subunit G Mfla_0577 56 COG1320 MnhG, Multisubunit Na+/H+ antiporter, MnhG subunit Inorganic ion transport and metabolism 91776884 Common - Type I secretion outer membrane protein, TolC Mfla_2534 146 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91774428 Common - transcriptional regulators, TraR/DksA family Mfla_0072 156 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 91776243 Common - peptidyl-prolyl cis-trans isomerase, cyclophilin type Mfla_1891 200 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 91775247 Common - hypothetical protein Mfla_0894 4 None None None 91776434 Common - glutaminyl-tRNA synthetase Mfla_2082 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 91774672 Nonpathogen - hypothetical protein Mfla_0316 2 None None None 91775183 Nonpathogen - hypothetical protein Mfla_0830 1 None None None 91775705 Common - putative FecR Mfla_1352 46 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 91776112 Common - Radical SAM Mfla_1759 55 COG4277 COG4277, Predicted DNA-binding protein with the Helix-hairpin-helix motif General function prediction only 91774522 Common - ABC-2 Mfla_0166 136 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 91774757 Common - 20S proteasome, A and B subunits Mfla_0401 54 COG3484 COG3484, Predicted proteasome-type protease Posttranslational modification, protein turnover, chaperones 91775431 Nonpathogen - hypothetical protein Mfla_1078 1 None None None 91775585 Common - transcriptional regulators, TraR/DksA family Mfla_1232 117 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 91774440 Common - methylation Mfla_0084 9 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 91774668 Common - ribosomal protein L28 Mfla_0312 166 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 91776873 Common - methylation Mfla_2523 91 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 91774589 Common - ResB-like protein Mfla_0233 43 COG1333 ResB, ResB protein required for cytochrome c biosynthesis Posttranslational modification, protein turnover, chaperones 91776815 Common - Indole-3-glycerol-phosphate synthase Mfla_2465 219 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 91774884 Common - diguanylate cyclase (GGDEF domain) Mfla_0529 179 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 91775629 Common - NAD-dependent epimerase/dehydratase Mfla_1276 220 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 91776350 Common - phenylalanyl-tRNA synthetase, beta subunit Mfla_1998 243 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 91774815 Nonpathogen - hypothetical protein Mfla_0460 1 None None None 91776288 Common - CheA signal transduction histidine kinases Mfla_1936 151 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 91774635 Common - ribosomal protein L3 Mfla_0279 227 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 91776596 Common - Pyruvate kinase Mfla_2244 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 91776697 Common - aldo/keto reductase Mfla_2345 184 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 91774395 Common - diguanylate cyclase (GGDEF domain) Mfla_0039 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 91774543 Common - Peptide deformylase Mfla_0187 214 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 91776561 Common - riboflavin biosynthesis protein RibF Mfla_2209 211 COG0196 RibF, FAD synthase Coenzyme metabolism 91775024 Common - hypothetical protein Mfla_0671 8 None None None 91776395 Common - extracellular solute-binding protein, family 3 Mfla_2043 18 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 91775297 Common - response regulator receiver domain protein (CheY-like) Mfla_0944 50 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 91776934 Common - protein of unknown function DUF1656 Mfla_2584 7 None None None 91775012 Common - protein of unknown function DUF482 Mfla_0657 81 COG3146 COG3146, Uncharacterized protein conserved in bacteria Function unknown 91776679 Common - protein of unknown function DUF205 Mfla_2327 167 COG0344 COG0344, Predicted membrane protein Function unknown 91775683 Common - replicative DNA helicase Mfla_1330 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 91775208 Common - L-aspartate oxidase Mfla_0855 226 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 91775806 Nonpathogen - hypothetical protein Mfla_1453 1 None None None 91775185 Nonpathogen - hypothetical protein Mfla_0832 1 None None None 91776218 Common dapD 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase Mfla_1866 149 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 91775424 Common rpsA 30S ribosomal protein S1 Mfla_1071 220 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 91776859 Common metH B12-dependent methionine synthase Mfla_2509 177 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 91775778 Common - methyltransferase small Mfla_1425 59 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 91777107 Common - protein of unknown function DUF37 Mfla_2759 186 COG0759 COG0759, Uncharacterized conserved protein Function unknown 91776532 Nonpathogen - hypothetical protein Mfla_2180 1 None None None 91774939 Common - peptidase U62, modulator of DNA gyrase Mfla_0584 156 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 91776250 Common - von Willebrand factor, type A Mfla_1898 24 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 91776293 Common - hypothetical protein Mfla_1941 22 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 91776749 Nonpathogen - hypothetical protein Mfla_2399 6 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 91775261 Common - Propeptide, PepSY amd peptidase M4 Mfla_0908 5 COG3212 COG3212, Predicted membrane protein Function unknown 91776455 Common - dihydroorotase, multifunctional complex type Mfla_2103 211 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 91776956 Common - restriction modification system DNA specificity domain Mfla_2606 91 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 91776386 Common - MxaD protein, putative Mfla_2034 15 None None None 91774514 Common - putative N,N-dimethylformamidase Mfla_0158 18 None None None 91776622 Common - cell cycle protein Mfla_2270 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 91775824 Common - membrane protein of unknown function Mfla_1471 37 COG1950 COG1950, Predicted membrane protein Function unknown 91774837 Common - putative transmembrane protein Mfla_0482 2 None None None 91774926 Common - CinA-like protein Mfla_0571 192 COG1546 CinA, Uncharacterized protein (competence- and mitomycin-induced) General function prediction only 91775621 Common - Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase Mfla_1268 164 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 91777099 Nonpathogen - ATP synthase protein I Mfla_2751 1 None None None 91776265 Common mtnA methylthioribose-1-phosphate isomerase Mfla_1913 130 COG0182 COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 91775591 Common - Peptidase M1, alanyl aminopeptidase Mfla_1238 159 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 91775449 Common - protein of unknown function DUF188 Mfla_1096 97 COG1671 COG1671, Uncharacterized protein conserved in bacteria Function unknown 91775342 Common - protein of unknown function UPF0227 Mfla_0989 46 COG3150 COG3150, Predicted esterase General function prediction only 91776920 Common - transcriptional regulator, LysR family Mfla_2570 181 COG0583 LysR, Transcriptional regulator Transcription 91775468 Common - protein of unknown function DUF454 Mfla_1115 78 COG2832 COG2832, Uncharacterized protein conserved in bacteria Function unknown 91776996 Common - Methyltransferase FkbM Mfla_2648 16 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 91776860 Common - Mg chelatase-related protein Mfla_2510 199 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 91774918 Common - molybdopterin oxidoreductase Mfla_0563 186 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 91775566 Common - Lytic murein transglycosylase Mfla_1213 107 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 91776085 Common - Alcohol dehydrogenase, zinc-binding Mfla_1732 168 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 91775310 Nonpathogen - hypothetical protein Mfla_0957 1 None None None 91775143 Common - glycosyl transferase, group 1 Mfla_0790 229 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 91774689 Nonpathogen - hypothetical protein Mfla_0333 2 None None None 91775765 Common - histone-like DNA-binding protein Mfla_1412 198 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 91775791 Common - NAD-dependent epimerase/dehydratase Mfla_1438 96 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 91774400 Common - protein serine/threonine phosphatases Mfla_0044 126 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 91774391 Common hemC porphobilinogen deaminase Mfla_0035 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 91776348 Common - transcriptional regulator, MerR family Mfla_1996 90 COG0789 SoxR, Predicted transcriptional regulators Transcription 91775536 Common - response regulator receiver modulated diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Mfla_1183 224 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 91776192 Common - CMP/dCMP deaminase, zinc-binding Mfla_1840 201 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 91775714 Common - periplasmic multidrug efflux lipoprotein precursor Mfla_1361 158 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 91774739 Common - carboxyl-terminal protease Mfla_0383 182 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 91774842 Common - glycosyl transferase, group 1 Mfla_0487 123 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 91774787 Common - two component transcriptional regulator, winged helix family Mfla_0432 219 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 91775484 Common - Lytic transglycosylase, catalytic Mfla_1131 106 COG4623 COG4623, Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein Cell envelope biogenesis, outer membrane 91775100 Nonpathogen - hypothetical protein Mfla_0747 1 None None None 91775964 Common - protein of unknown function DUF152 Mfla_1611 181 COG1496 COG1496, Uncharacterized conserved protein Function unknown 91776164 Common - hypothetical protein Mfla_1812 35 None None None 91776627 Common - Peptidoglycan glycosyltransferase Mfla_2275 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 91774989 Nonpathogen - hypothetical protein Mfla_0634 2 COG5456 COG5456, Predicted integral membrane protein linked to a cation pump Inorganic ion transport and metabolism 91776737 Common - TonB-dependent siderophore receptor Mfla_2387 124 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 91775402 Common - threonine synthase Mfla_1049 136 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 91776929 Common - hypothetical protein Mfla_2579 36 COG5501 COG5501, Predicted secreted protein Function unknown 91775008 Common - histidine kinase Mfla_0653 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 91774992 Common - bacterioferritin Mfla_0637 97 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 91774996 Common - protein of unknown function DUF45 Mfla_0641 153 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 91775698 Common - Type I secretion outer membrane protein, TolC Mfla_1345 135 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91776605 Nonpathogen - hypothetical protein Mfla_2253 2 None None None 91775117 Common - Methyltransferase FkbM Mfla_0764 58 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 91775334 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Mfla_0981 219 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 91776825 Common - hypothetical protein Mfla_2475 16 COG3305 COG3305, Predicted membrane protein Function unknown 91776891 Common - Ribonucleoside-diphosphate reductase Mfla_2541 219 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 91776199 Common - binding-protein-dependent transport systems inner membrane component Mfla_1847 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 91775689 Common - type II and III secretion system protein Mfla_1336 140 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 91774407 Common - YjgF-like protein Mfla_0051 184 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 91776941 Common - short-chain dehydrogenase/reductase SDR Mfla_2591 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 91775106 Common - Lipopolysaccharide heptosyltransferase I Mfla_0753 98 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 91775905 Common - protein of unknown function DUF81 Mfla_1552 40 COG0730 COG0730, Predicted permeases General function prediction only 91776549 Nonpathogen - hypothetical protein Mfla_2197 1 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 91775950 Common - zinc/iron permease Mfla_1597 53 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 91775458 Common - Dihydroxyacetone kinase, subunit L Mfla_1105 76 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 91776963 Common - transcriptional regulator, ArsR family Mfla_2614 79 COG0640 ArsR, Predicted transcriptional regulators Transcription 91775930 Common - N-ethylammeline chlorohydrolase Mfla_1577 180 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 91774827 Common - transcriptional regulator, TetR family Mfla_0472 103 COG1309 AcrR, Transcriptional regulator Transcription 91776573 Nonpathogen - outer membrane efflux protein Mfla_2221 11 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91776916 Common - Heavy metal efflux pump CzcA Mfla_2566 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 91775863 Common - protein of unknown function DUF177 Mfla_1510 55 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 91775354 Common - hypothetical protein Mfla_1001 20 COG3073 RseA, Negative regulator of sigma E activity Signal transduction mechanisms 91775153 Common - carbonic anhydrase Mfla_0800 138 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 91776521 Common - cyanate hydratase Mfla_2169 41 COG1513 CynS, Cyanate lyase Inorganic ion transport and metabolism 91775127 Common - NAD(+) kinase Mfla_0774 239 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 91775756 Common - DNA ligase, NAD-dependent Mfla_1403 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 91774885 Common - glucose sorbosone dehydrogenase Mfla_0530 102 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 91775382 Common - Endonuclease/exonuclease/phosphatase Mfla_1029 25 COG3021 COG3021, Uncharacterized protein conserved in bacteria Function unknown 91774800 Common - two component transcriptional regulator, LuxR family Mfla_0445 216 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 91775110 Common - hypothetical protein Mfla_0757 5 COG1718 RIO1, Serine/threonine protein kinase involved in cell cycle control Signal transduction mechanisms / Cell division and chromosome partitioning 91776445 Common - DNA internalization-related competence protein ComEC/Rec2 Mfla_2093 145 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 91776838 Common gatB aspartyl/glutamyl-tRNA amidotransferase subunit B Mfla_2488 212 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 91775398 Common - 4Fe-4S ferredoxin, iron-sulfur binding Mfla_1045 78 COG0348 NapH, Polyferredoxin Energy production and conversion 91777035 Common - hypothetical protein Mfla_2687 4 None None None 91774592 Nonpathogen - methylation Mfla_0236 7 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 91775781 Common - hypothetical protein Mfla_1428 22 COG4244 COG4244, Predicted membrane protein Function unknown 91776831 Common - Methionine biosynthesis MetW Mfla_2481 60 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 91775273 Common - protein of unknown function DUF59 Mfla_0920 234 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 91775033 Common - outer membrane lipoprotein LolB Mfla_0680 56 COG3017 LolB, Outer membrane lipoprotein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 91775062 Nonpathogen - hypothetical protein Mfla_0709 2 None None None 91775879 Common - undecaprenyl diphosphate synthase Mfla_1526 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 91775842 Common - Arsenical pump membrane protein Mfla_1489 85 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 91776001 Common - para-aminobenzoate synthase, component I Mfla_1648 223 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 91774414 Common - hypothetical protein Mfla_0058 12 None None None 91775130 Common - Dihydrodipicolinate reductase Mfla_0777 217 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 91774471 Common - Cob(II)yrinic acid a,c-diamide reductase Mfla_0115 111 COG0778 NfnB, Nitroreductase Energy production and conversion 91776037 Common - histidinol-phosphate aminotransferase Mfla_1684 236 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 91776016 Common - Amidohydrolase 3 Mfla_1663 24 COG1229 FwdA, Formylmethanofuran dehydrogenase subunit A Energy production and conversion 91776018 Common - Formylmethanofuran dehydrogenase Mfla_1665 93 COG2218 FwdC, Formylmethanofuran dehydrogenase subunit C Energy production and conversion 91774760 Common - putative ATP-dependent DNA helicase-related protein Mfla_0404 79 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 91775927 Common recR recombination protein RecR Mfla_1574 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 91774661 Common - ribosomal protein L17 Mfla_0305 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 91776304 Common - anti-sigma-28 factor, FlgM Mfla_1952 18 COG2747 FlgM, Negative regulator of flagellin synthesis (anti-sigma28 factor) Transcription / Cell motility and secretion / Intracellular trafficking and secretion 91775937 Common - tRNA synthetase, class II (G, H, P and S) Mfla_1584 196 COG3705 HisZ, ATP phosphoribosyltransferase involved in histidine biosynthesis Amino acid transport and metabolism 91775918 Common - monooxygenase, putative Mfla_1565 12 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 91776867 Common - glutathione synthetase Mfla_2517 116 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 91775691 Common - putative transmembrane protein Mfla_1338 10 None None None 91776861 Common - protein of unknown function DUF526 Mfla_2511 30 COG2960 COG2960, Uncharacterized protein conserved in bacteria Function unknown 91775081 Common - electron transfer flavoprotein, alpha subunit Mfla_0728 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 91776896 Common - Cation/multidrug efflux pump-like protein Mfla_2546 172 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 91775854 Common - aminodeoxychorismate lyase Mfla_1501 185 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 91775724 Common - hypothetical protein Mfla_1371 162 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 91776213 Common cysM cysteine synthase B Mfla_1861 224 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 91776385 Common - Pyridoxal-dependent decarboxylase Mfla_2033 92 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 91774971 Common - major membrane protein I Mfla_0616 27 None None None 91776555 Common - phosphoenolpyruvate synthase Mfla_2203 235 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 91775156 Common - Ferredoxin, 2Fe-2S type Mfla_0803 98 COG0633 Fdx, Ferredoxin Energy production and conversion 91776808 Common - type IV pilus assembly protein PilP Mfla_2458 38 COG3168 PilP, Tfp pilus assembly protein PilP Cell motility and secretion / Intracellular trafficking and secretion 91774528 Common - exodeoxyribonuclease III (xth) Mfla_0172 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 91776223 Nonpathogen - protein of unknown function DUF202 Mfla_1871 6 COG2149 COG2149, Predicted membrane protein Function unknown 91774501 Common - hypothetical protein Mfla_0145 140 COG1660 COG1660, Predicted P-loop-containing kinase General function prediction only 91776709 Nonpathogen - conserved hypothetical signal peptide protein Mfla_2357 4 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 91775746 Common - ABC transporter related Mfla_1393 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 91776464 Common - ribonuclease, Rne/Rng family Mfla_2112 184 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 91774905 Common - hypothetical protein Mfla_0550 14 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 91776716 Common - conserved hypothetical protein-putative formaldehyde-activating enzyme Mfla_2364 25 COG1795 COG1795, Uncharacterized conserved protein Function unknown 91775713 Common - multidrug efflux protein Mfla_1360 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 91774500 Common - HPr kinase/phosphorylase Mfla_0144 70 COG1493 HprK, Serine kinase of the HPr protein, regulates carbohydrate metabolism Signal transduction mechanisms 91776447 Common - Lipoprotein releasing system, transmembrane protein, LolC/E family Mfla_2095 167 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 91775614 Common - protein of unknown function DUF195 Mfla_1261 145 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 91776344 Common - sulphate transporter Mfla_1992 159 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 91775026 Common - hypothetical protein Mfla_0673 19 COG3652 COG3652, Predicted outer membrane protein Function unknown 91775578 Common - ferredoxin Mfla_1225 48 COG0633 Fdx, Ferredoxin Energy production and conversion 91776714 Common - NAD(P)H dehydrogenase (quinone) Mfla_2362 73 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 91774484 Common - threonine dehydratase Mfla_0128 207 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 91775999 Common - transcriptional coactivator/pterin dehydratase Mfla_1646 63 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 91775338 Common - beta-lactamase-like protein Mfla_0985 64 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 91776635 Common - hypothetical protein Mfla_2283 140 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 91775511 Common - peptidase S1 and S6, chymotrypsin/Hap Mfla_1158 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 91774478 Common - TonB-dependent receptor Mfla_0122 129 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 91774892 Common - TonB-dependent siderophore receptor Mfla_0537 116 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 91776326 Common - Flagellar export FliJ Mfla_1974 35 COG2882 FliJ, Flagellar biosynthesis chaperone Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 91775881 Common pyrH uridylate kinase Mfla_1528 238 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 91776545 Common - TonB-dependent receptor Mfla_2193 61 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 91775877 Common - 1-deoxy-D-xylulose 5-phosphate reductoisomerase Mfla_1524 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 91774655 Common secY preprotein translocase subunit SecY Mfla_0299 225 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 91775839 Nonpathogen - hypothetical protein Mfla_1486 1 None None None 91776312 Common - flagellar L-ring protein Mfla_1960 85 COG2063 FlgH, Flagellar basal body L-ring protein Cell motility and secretion 91776126 Common - inner-membrane translocator Mfla_1773 148 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 91776458 Common - twitching motility protein Mfla_2106 216 COG5008 PilU, Tfp pilus assembly protein, ATPase PilU Cell motility and secretion / Intracellular trafficking and secretion 91775266 Common - periplasmic sensor signal transduction histidine kinase Mfla_0913 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 91777046 Common - hypothetical protein Mfla_2698 7 COG2369 COG2369, Uncharacterized protein, homolog of phage Mu protein gp30 Function unknown 91775317 Nonpathogen - hypothetical protein Mfla_0964 1 None None None 91776420 Common - putative partition-related protein Mfla_2068 93 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 91777083 Nonpathogen - hypothetical protein Mfla_2735 1 None None None 91776115 Common - periplasmic sensor hybrid histidine kinase Mfla_1762 226 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 91775848 Common - transposase Tn3 Mfla_1495 56 COG4644 COG4644, Transposase and inactivated derivatives, TnpA family DNA replication, recombination, and repair 91776154 Common - short-chain dehydrogenase/reductase SDR Mfla_1802 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 91775867 Common - hypothetical protein Mfla_1514 24 COG5316 COG5316, Uncharacterized conserved protein Function unknown 91776048 Common - FolC bifunctional protein Mfla_1695 218 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 91775911 Common - Biopolymer transport protein ExbD/TolR Mfla_1558 145 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 91775475 Nonpathogen - hypothetical protein Mfla_1122 2 None None None 91775001 Common - apolipoprotein N-acyltransferase Mfla_0646 165 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 91775925 Common - DNA polymerase III, subunits gamma and tau Mfla_1572 248 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 91774617 Common - peptidase S1 and S6, chymotrypsin/Hap Mfla_0261 223 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 91774632 Common - elongation factor G Mfla_0276 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 91776872 Common - methylation Mfla_2522 7 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 91774580 Nonpathogen - hypothetical protein Mfla_0224 1 None None None 91776994 Common - Rieske (2Fe-2S) region Mfla_2646 81 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 91775249 Common - Rhs element Vgr protein Mfla_0896 23 COG3501 VgrG, Uncharacterized protein conserved in bacteria Function unknown 91776091 Common - hypothetical protein Mfla_1738 88 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 91774721 Common - chaperonin Cpn10 Mfla_0365 216 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 91774384 Common - Protein-disulfide reductase Mfla_0028 174 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 91776174 Common - protein of unknown function DUF88 Mfla_1822 79 COG1432 COG1432, Uncharacterized conserved protein Function unknown 91776689 Common - Tetratricopeptide region Mfla_2337 73 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 91775749 Nonpathogen - hypothetical protein Mfla_1396 1 None None None 91774370 Nonpathogen - hypothetical protein Mfla_0014 1 None None None 91774457 Common - aminotransferase, class I and II Mfla_0101 213 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 91776337 Common - flagellar protein FlaG protein Mfla_1985 29 COG1334 FlaG, Uncharacterized flagellar protein FlaG Cell motility and secretion 91776644 Common - glycosyl transferase, family 39 Mfla_2292 25 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 161611347 Common pyrE orotate phosphoribosyltransferase Mfla_2485 138 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 91775350 Common - Phosphomethylpyrimidine kinase Mfla_0997 219 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 91776028 Common - 4Fe-4S ferredoxin, iron-sulfur binding Mfla_1675 116 COG1146 COG1146, Ferredoxin Energy production and conversion 91776730 Common - Endonuclease/exonuclease/phosphatase Mfla_2380 69 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 91776159 Common - protein of unknown function DUF519 Mfla_1807 85 COG2961 ComJ, Protein involved in catabolism of external DNA General function prediction only 91774587 Common - hypothetical protein Mfla_0231 177 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 91777001 Common - TonB-dependent receptor Mfla_2653 84 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 91774363 Common - cyclase/dehydrase Mfla_0007 36 COG5637 COG5637, Predicted integral membrane protein Function unknown 91776902 Common - secretion protein HlyD Mfla_2552 145 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 91775139 Common - phosphoesterase, PA-phosphatase related Mfla_0786 58 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 91775323 Nonpathogen - hypothetical protein Mfla_0970 1 None None None 91775164 Common - serine O-acetyltransferase Mfla_0811 208 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 91775571 Common - DEAD/DEAH box helicase-like protein Mfla_1218 103 COG1204 COG1204, Superfamily II helicase General function prediction only 91775528 Common - type I site-specific deoxyribonuclease, HsdR family Mfla_1175 135 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 91775170 Common - signal transduction histidine kinase, glucose-6-phosphate specific Mfla_0817 147 COG3851 UhpB, Signal transduction histidine kinase, glucose-6-phosphate specific Signal transduction mechanisms 91776230 Common - intracellular septation protein A Mfla_1878 91 COG2917 COG2917, Intracellular septation protein A Cell division and chromosome partitioning 91776358 Nonpathogen - hypothetical protein Mfla_2006 1 None None None 91774495 Common - protein of unknown function DUF1239 Mfla_0139 33 COG3117 COG3117, Uncharacterized protein conserved in bacteria Function unknown 91775067 Common - protein of unknown function DUF861, cupin_3 Mfla_0714 23 COG3450 COG3450, Predicted enzyme of the cupin superfamily General function prediction only 91775445 Common - periplasmic sensor signal transduction histidine kinase Mfla_1092 147 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 91775256 Common - aminotransferase AlaT Mfla_0903 239 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 91776727 Common katE hydroperoxidase II Mfla_2377 126 COG0753 KatE, Catalase Inorganic ion transport and metabolism 91775456 Common - Secretion chaperone CsaA Mfla_1103 104 COG0073 ARC1, EMAP domain General function prediction only 91776056 Common - 3-isopropylmalate dehydrogenase Mfla_1703 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 91774728 Common - RND efflux system, outer membrane lipoprotein, NodT Mfla_0372 112 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91774871 Common - hypothetical protein Mfla_0516 12 None None None 91776651 Common - transcriptional regulator, GntR family Mfla_2299 104 COG2188 PhnF, Transcriptional regulators Transcription 91775228 Nonpathogen - hypothetical protein Mfla_0875 1 None None None 91776857 Common - TonB-like protein Mfla_2507 37 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 91775271 Common - 6-phosphogluconate dehydrogenase-like protein Mfla_0918 185 COG1023 Gnd, Predicted 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 91776107 Common - hypothetical protein Mfla_1754 23 COG4394 COG4394, Uncharacterized protein conserved in bacteria Function unknown 91775278 Nonpathogen - hypothetical protein Mfla_0925 4 COG5416 COG5416, Uncharacterized integral membrane protein Function unknown 91776965 Common - NUDIX hydrolase Mfla_2616 171 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 91775943 Common - glutamyl-tRNA synthetase Mfla_1590 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 91776149 Nonpathogen - hypothetical protein Mfla_1797 1 None None None 91774813 Common - glutamate synthase, alpha subunit-like protein Mfla_0458 33 COG0070 GltB, Glutamate synthase domain 3 Amino acid transport and metabolism 91776232 Common - BolA-like protein Mfla_1880 29 COG0271 BolA, Stress-induced morphogen (activity unknown) Signal transduction mechanisms 91776592 Common - Inorganic diphosphatase Mfla_2240 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 91774605 Common - histidinol-phosphate aminotransferase Mfla_0249 232 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 91776306 Common - flagellar basal-body rod protein FlgB Mfla_1954 95 COG1815 FlgB, Flagellar basal body protein Cell motility and secretion 91775518 Common - hypothetical protein Mfla_1165 8 None None None 91775553 Common - AsmA Mfla_1200 41 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 91775561 Common - hypothetical protein Mfla_1208 33 None None None 91774773 Nonpathogen - hypothetical protein Mfla_0418 1 None None None 91775663 Common - transposase IS3/IS911 Mfla_1310 11 None None None 91776947 Common - hypothetical protein Mfla_2597 7 None None None 91775985 Common - acriflavin resistance protein Mfla_1632 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 91774974 Common - hypothetical protein Mfla_0619 17 COG4378 COG4378, Uncharacterized protein conserved in bacteria Function unknown 91774951 Common - pantoate--beta-alanine ligase Mfla_0596 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 91774824 Common - conserved hypothetical protein, predicted autoinducer synthesis protein family Mfla_0469 64 COG3176 COG3176, Putative hemolysin General function prediction only 91777056 Common - hypothetical protein Mfla_2708 4 None None None 91776978 Common - hypothetical protein Mfla_2630 70 None None None 91775873 Common - UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase Mfla_1520 162 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 91774552 Common - Diaminopimelate epimerase Mfla_0196 203 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 91776209 Common - ABC transporter related Mfla_1857 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 91776023 Common - protein of unknown function DUF81 Mfla_1670 44 COG0730 COG0730, Predicted permeases General function prediction only 91775291 Common - Heavy metal translocating P-type ATPase Mfla_0938 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 91775077 Common - D-3-phosphoglycerate dehydrogenase Mfla_0724 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 91775989 Nonpathogen - hypothetical protein Mfla_1636 1 None None None 91775786 Common - cytochrome C oxidase, mono-heme subunit/FixO Mfla_1433 82 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 91776506 Common - methyl-accepting chemotaxis sensory transducer Mfla_2154 146 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 91775489 Common - nitroreductase Mfla_1136 113 COG0778 NfnB, Nitroreductase Energy production and conversion 91775531 Common - hypothetical protein Mfla_1178 3 None None None 91774460 Nonpathogen - hypothetical protein Mfla_0104 1 None None None 91776372 Common - polysaccharide pyruvyl transferase Mfla_2020 23 COG2327 WcaK, Uncharacterized conserved protein Function unknown 91776775 Common - major facilitator superfamily MFS_1 Mfla_2425 198 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 91774576 Common - permease YjgP/YjgQ Mfla_0220 133 COG0795 COG0795, Predicted permeases General function prediction only 91775361 Common - GTP-binding protein Era Mfla_1008 231 COG1159 Era, GTPase General function prediction only 91775055 Common - sigma 32 (RpoH) Mfla_0702 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 91776167 Common - sigma54 specific transcriptional regulator, Fis family Mfla_1815 174 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 91775288 Common - outer membrane efflux protein Mfla_0935 20 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91775626 Common - glycosyl transferase, group 1 Mfla_1273 208 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 91776585 Common - protein of unknown function DUF1289 Mfla_2233 35 COG3313 COG3313, Predicted Fe-S protein General function prediction only 91775345 Common - hypothetical protein Mfla_0992 9 COG5581 COG5581, Predicted glycosyltransferase Cell envelope biogenesis, outer membrane 91775957 Common - Haemin-degrading Mfla_1604 40 COG3720 HemS, Putative heme degradation protein Inorganic ion transport and metabolism 91774959 Common - CRISPR-associated protein TM1801 Mfla_0604 55 COG3649 COG3649, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 91776133 Nonpathogen - hypothetical protein Mfla_1780 1 None None None 91774841 Common - Amylo-alpha-1,6-glucosidase Mfla_0486 51 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 91775580 Common - hypothetical protein Mfla_1227 19 None None None 91775635 Common - response regulator receiver domain protein (CheY-like) Mfla_1282 86 COG4753 COG4753, Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain Signal transduction mechanisms 91776701 Common - binding-protein-dependent transport systems inner membrane component Mfla_2349 144 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 91775244 Common - Twin-arginine translocation pathway signal Mfla_0891 77 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 91776291 Common motB flagellar motor protein MotB Mfla_1939 106 COG1360 MotB, Flagellar motor protein Cell motility and secretion 91774582 Common - peptidase S11, D-alanyl-D-alanine carboxypeptidase 1 Mfla_0226 153 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 91774966 Common - Sulfate ABC transporter, permease protein CysT Mfla_0611 234 COG0555 CysU, ABC-type sulfate transport system, permease component Posttranslational modification, protein turnover, chaperones 91774399 Common - ribonuclease PH Mfla_0043 181 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 91777078 Common - hypothetical protein Mfla_2730 23 None None None 91774538 Common - periplasmic sensor signal transduction histidine kinase Mfla_0182 223 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 91776134 Common - putative prophage repressor Mfla_1781 168 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 91775371 Common - 30S ribosomal protein S4 Mfla_1018 234 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 91775990 Common - hypothetical protein Mfla_1637 10 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 91775121 Common - Lipopolysaccharide heptosyltransferase II Mfla_0768 85 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 91774860 Common - nitrogen regulatory protein P-II (GlnB, GlnK) Mfla_0505 184 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 91775904 Common - Peroxidase Mfla_1551 209 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 91776421 Common - adenylate cyclase Mfla_2069 71 COG3025 COG3025, Uncharacterized conserved protein Function unknown 91774497 Common - ABC transporter related Mfla_0141 249 COG1137 YhbG, ABC-type (unclassified) transport system, ATPase component General function prediction only 91776374 Nonpathogen - hypothetical protein Mfla_2022 7 None None None 91776125 Common - ABC transporter related Mfla_1772 249 COG4674 COG4674, Uncharacterized ABC-type transport system, ATPase component General function prediction only 91774624 Common - ribosomal protein L11 Mfla_0268 246 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 91776274 Common - peptidase A2A, retrovirus, catalytic Mfla_1922 55 COG3577 COG3577, Predicted aspartyl protease General function prediction only 91774960 Common - CRISPR-associated protein Cas4 Mfla_0605 51 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 91775179 Nonpathogen - hypothetical protein Mfla_0826 1 None None None 91774785 Common - multi-sensor signal transduction histidine kinase Mfla_0430 219 COG4252 COG4252, Predicted transmembrane sensor domain Signal transduction mechanisms 91776792 Common - hypothetical protein Mfla_2442 14 None None None 91776768 Common - hypothetical protein Mfla_2418 5 None None None 91776204 Common - hypothetical protein Mfla_1852 31 COG3298 COG3298, Predicted 3'-5' exonuclease related to the exonuclease domain of PolB DNA replication, recombination, and repair 91776986 Common - thiamine biosynthesis protein ThiS Mfla_2638 43 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 91775308 Common - Pseudouridine synthase, Rsu Mfla_0955 189 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 91775980 Nonpathogen - hypothetical protein Mfla_1627 1 None None None 91775808 Common - hypothetical protein Mfla_1455 2 None None None 91776087 Common - transcriptional regulator, Crp/Fnr family Mfla_1734 86 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 91775820 Common - 5'-methylthioadenosine phosphorylase Mfla_1467 160 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 91774896 Common - hypothetical protein Mfla_0541 10 COG2361 COG2361, Uncharacterized conserved protein Function unknown 91776788 Nonpathogen - hypothetical protein Mfla_2438 3 None None None 91776958 Common - PfkB Mfla_2609 126 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 91775679 Common - ribosomal protein S6 Mfla_1326 205 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 91776541 Common - peptidase M23B Mfla_2189 181 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 91774683 Common - nitrate transporter periplasmic component Mfla_0327 83 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 91775347 Common - electron transport complex, RnfABCDGE type, B subunit Mfla_0994 118 COG2878 COG2878, Predicted NADH:ubiquinone oxidoreductase, subunit RnfB Energy production and conversion 91776932 Common - RND efflux system, outer membrane lipoprotein, NodT Mfla_2582 128 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91776773 Nonpathogen - protein of unknown function DUF1555 Mfla_2423 3 None None None 91775403 Common - Thymidylate synthase Mfla_1050 141 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 91776245 Common - beta-ketoacyl synthase Mfla_1893 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 91776904 Common - protein of unknown function UPF0060 Mfla_2554 77 COG1742 COG1742, Uncharacterized conserved protein Function unknown 91774512 Common - inner-membrane translocator Mfla_0156 154 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 91775426 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Mfla_1073 229 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 91776529 Common - hypothetical protein Mfla_2177 34 None None None 91774412 Common - ribosomal protein S9 Mfla_0056 249 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 91774746 Common - ABC-1 Mfla_0390 184 COG0661 AarF, Predicted unusual protein kinase General function prediction only 91777017 Common - short-chain dehydrogenase/reductase SDR Mfla_2669 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 91775035 Common - ABC transporter related Mfla_0682 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 91776276 Common - acetyltransferase, GNAT family Mfla_1924 26 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 91774663 Common - MscS Mechanosensitive ion channel Mfla_0307 190 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 91774839 Common - Hemolysin activator HlyB Mfla_0484 30 COG2831 FhaC, Hemolysin activation/secretion protein Intracellular trafficking and secretion 91775166 Common - inositol monophosphatase Mfla_0813 213 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 91774831 Common - FAD linked oxidase-like protein Mfla_0476 188 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 91774924 Common - regulatory protein RecX Mfla_0569 58 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 91774637 Common rplW 50S ribosomal protein L23 Mfla_0281 210 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 91777010 Common - Phosphomethylpyrimidine kinase Mfla_2662 220 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 91774670 Common - phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase Mfla_0314 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 91775521 Common - ATP-dependent metalloprotease FtsH Mfla_1168 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 91774933 Common - putative monovalent cation/H+ antiporter subunit F Mfla_0578 82 COG2212 MnhF, Multisubunit Na+/H+ antiporter, MnhF subunit Inorganic ion transport and metabolism 91776430 Nonpathogen - hypothetical protein Mfla_2078 1 None None None 91775181 Common - hypothetical protein Mfla_0828 5 None None None 91776436 Nonpathogen - hypothetical protein Mfla_2084 2 None None None 91774911 Common - blue (type 1) copper domain Mfla_0556 19 COG3241 COG3241, Azurin Energy production and conversion 91774759 Common - transmembrane pair Mfla_0403 41 COG4125 COG4125, Predicted membrane protein Function unknown 91776073 Common - hypothetical protein Mfla_1720 12 COG1462 CsgG, Uncharacterized protein involved in formation of curli polymers Cell envelope biogenesis, outer membrane 91776014 Common - GHMP kinase group 1 Mfla_1661 55 COG1907 COG1907, Predicted archaeal sugar kinases General function prediction only 91775201 Common - hypothetical protein Mfla_0848 9 COG5581 COG5581, Predicted glycosyltransferase Cell envelope biogenesis, outer membrane 91776478 Common - methylation Mfla_2126 22 COG4969 PilA, Tfp pilus assembly protein, major pilin PilA Cell motility and secretion / Intracellular trafficking and secretion 91775736 Common - hypothetical protein Mfla_1383 20 COG1359 COG1359, Uncharacterized conserved protein Function unknown 91775827 Common - Ste24 endopeptidase Mfla_1474 72 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 91776882 Common - secretion protein HlyD Mfla_2532 161 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 91776580 Common - protein of unknown function DUF329 Mfla_2228 74 COG3024 COG3024, Uncharacterized protein conserved in bacteria Function unknown 91776813 Common - hypothetical protein Mfla_2463 24 None None None 91775563 Common - protein of unknown function DUF461 Mfla_1210 83 COG2847 COG2847, Uncharacterized protein conserved in bacteria Function unknown 91776594 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase Mfla_2242 199 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 91774901 Common - hypothetical protein Mfla_0546 31 None None None 91776160 Common - hypothetical protein Mfla_1808 55 COG2862 COG2862, Predicted membrane protein Function unknown 91775286 Nonpathogen - hypothetical protein Mfla_0933 1 None None None 91775095 Common - secretion protein HlyD Mfla_0742 173 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 91775583 Common - cobalamin synthesis protein, P47K Mfla_1230 125 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 91775884 Common - methionine aminopeptidase Mfla_1531 246 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 91776771 Common - General secretion pathway protein G Mfla_2421 75 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 91775074 Common - NADH dehydrogenase (quinone) Mfla_0721 165 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 91774751 Nonpathogen - hypothetical protein Mfla_0395 1 None None None 91776603 Common - protein of unknown function DUF558 Mfla_2251 202 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 91774640 Common - ribosomal protein L22 Mfla_0284 215 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 91775407 Nonpathogen - hypothetical protein Mfla_1054 3 None None None 91775487 Common - conserved hypothetical chaperone protein Mfla_1134 157 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 91775812 Nonpathogen - hypothetical protein Mfla_1459 1 None None None 91776286 Common - methyl-accepting chemotaxis sensory transducer Mfla_1934 145 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 91775681 Common rpsR 30S ribosomal protein S18 Mfla_1328 214 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 91776547 Nonpathogen - protein of unknown function DUF1555 Mfla_2195 4 None None None 91776064 Common - Rieske (2Fe-2S) region Mfla_1711 81 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 91775928 Common - phosphoglycolate phosphatase Mfla_1575 198 COG0546 Gph, Predicted phosphatases General function prediction only 91776398 Common - NUDIX hydrolase Mfla_2046 158 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 91774714 Common - DNA polymerase I Mfla_0358 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 91774693 Nonpathogen - hypothetical protein Mfla_0337 1 None None None 91775916 Common - sulfonate ABC transporter, periplasmic sulfonate-binding protein SsuA Mfla_1563 83 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 91774852 Common - Peptidylprolyl isomerase Mfla_0497 196 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 91775396 Common - sigma54 specific transcriptional regulator with GAF sensor, Fis family Mfla_1043 177 COG3284 AcoR, Transcriptional activator of acetoin/glycerol metabolism Secondary metabolites biosynthesis, transport, and catabolism / Transcription 91775623 Common - NDP-hexose 3-C-methyltransferase TylCIII Mfla_1270 37 None None None 91774771 Common - protein of unknown function DUF477 Mfla_0416 86 COG1512 COG1512, Beta-propeller domains of methanol dehydrogenase type General function prediction only 91774594 Common - protein of unknown function DUF140 Mfla_0238 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 91775852 Common - DNA polymerase III, delta prime subunit Mfla_1499 216 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 91775352 Common - L-aspartate oxidase Mfla_0999 226 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 91775976 Common - hypothetical protein Mfla_1623 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 91776918 Common - outer membrane efflux protein Mfla_2568 109 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91775045 Common - von Willebrand factor, type A Mfla_0692 9 None None None 91776469 Common - nicotinate-nucleotide pyrophosphorylase Mfla_2117 205 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 91776620 Common murC UDP-N-acetylmuramate--L-alanine ligase Mfla_2268 211 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 91775133 Common - GreA/GreB family elongation factor Mfla_0780 203 COG0782 GreA, Transcription elongation factor Transcription 91775299 Nonpathogen - hypothetical protein Mfla_0946 1 None None None 91776437 Common - peptide methionine sulfoxide reductase Mfla_2085 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 91776523 Common - nitrate transport permease Mfla_2171 188 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 91776827 Common - Beta-lactamase Mfla_2477 37 COG2602 COG2602, Beta-lactamase class D Defense mechanisms 91775966 Common - putative competence lipoprotein precursor Mfla_1613 123 COG4105 ComL, DNA uptake lipoprotein General function prediction only 91775237 Common - hypothetical protein Mfla_0884 7 None None None 91774473 Nonpathogen - MotA/TolQ/ExbB proton channel Mfla_0117 1 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 91776706 Common - crossover junction endodeoxyribonuclease RuvC Mfla_2354 197 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 91775064 Nonpathogen - hypothetical protein Mfla_0711 1 None None None 91775754 Common - Chromosome segregation protein SMC Mfla_1401 175 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 91777037 Common - hypothetical protein Mfla_2689 27 COG5281 COG5281, Phage-related minor tail protein Function unknown 91775934 Common - dihydropteroate synthase, DHPS Mfla_1581 32 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 91777030 Common - DNA adenine methylase Mfla_2682 100 COG0338 Dam, Site-specific DNA methylase DNA replication, recombination, and repair 91774887 Common - hypothetical protein Mfla_0532 5 None None None 91775388 Common - Twin-arginine translocation pathway signal Mfla_1035 77 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 91776865 Nonpathogen - hypothetical protein Mfla_2515 1 None None None 91776485 Common - deoxyxylulose-5-phosphate synthase Mfla_2133 227 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 91775389 Common - hypothetical protein Mfla_1036 15 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 91774766 Common - Helicase c2 Mfla_0411 137 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 91776575 Common - ABC transporter related Mfla_2223 46 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 91776894 Common - RND efflux system, outer membrane lipoprotein, NodT Mfla_2544 112 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91775086 Common - signal recognition particle-docking protein FtsY Mfla_0733 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 91774799 Common - signal transduction histidine kinase, nitrate/nitrite-specific, NarQ Mfla_0444 85 COG3850 NarQ, Signal transduction histidine kinase, nitrate/nitrite-specific Signal transduction mechanisms 91774564 Common - Fmu (Sun) Mfla_0208 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 91775793 Nonpathogen - hypothetical protein Mfla_1440 1 None None None 91776364 Common - Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase Mfla_2012 164 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 91775144 Common - D-amino acid dehydrogenase small subunit Mfla_0791 129 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 91774873 Common - GreA/GreB family elongation factor Mfla_0518 131 COG0782 GreA, Transcription elongation factor Transcription 91776530 Nonpathogen - hypothetical protein Mfla_2178 1 None None None 91776847 Common - Serine-type D-Ala-D-Ala carboxypeptidase Mfla_2497 155 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 91775768 Nonpathogen - hypothetical protein Mfla_1415 1 None None None 91775631 Common - polysaccharide biosynthesis protein CapD Mfla_1278 187 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 91774376 Common - transcriptional regulator, LysR family Mfla_0020 191 COG0583 LysR, Transcriptional regulator Transcription 91775534 Common - hypothetical protein Mfla_1181 10 None None None 91776990 Common - 3-oxoacyl-(acyl-carrier protein) synthase Mfla_2642 222 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 91774622 Common - SecE subunit of protein translocation complex Mfla_0266 85 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 91775094 Common - acetate kinase Mfla_0741 161 COG0282 ackA, Acetate kinase Energy production and conversion 91776190 Common - protein of unknown function DUF58 Mfla_1838 44 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 91774431 Common - general secretion pathway protein, ATPase Mfla_0075 69 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 91776564 Nonpathogen - hypothetical protein Mfla_2212 3 None None None 91776008 Common - transaldolase B Mfla_1655 175 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 91775665 Common - hypothetical protein Mfla_1312 13 COG5428 COG5428, Uncharacterized conserved small protein Function unknown 91775332 Nonpathogen - hypothetical protein Mfla_0979 1 None None None 91775006 Common - tRNA-i(6)A37 modification enzyme MiaB Mfla_0651 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 91776551 Common - hypothetical protein Mfla_2199 11 None None None 91775770 Common - Malto-oligosyltrehalose trehalohydrolase Mfla_1417 161 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 91774679 Common - putative methyl-accepting chemotaxis sensory transducer Mfla_0323 25 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 91776397 Common - NAD-dependent epimerase/dehydratase Mfla_2045 103 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 91774687 Common - formate/nitrite transporter Mfla_0331 91 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 91775763 Common clpX ATP-dependent protease ATP-binding subunit Mfla_1410 223 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 91776557 Common - DoxX Mfla_2205 30 COG2259 COG2259, Predicted membrane protein Function unknown 91774809 Common - Aminomethyltransferase Mfla_0454 184 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 91775440 Common - cytochrome bd ubiquinol oxidase, subunit I Mfla_1087 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 91777021 Common argS arginyl-tRNA synthetase Mfla_2673 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 91775014 Common - cyclase/dehydrase Mfla_0659 31 COG5637 COG5637, Predicted integral membrane protein Function unknown 91774737 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Mfla_0381 14 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 91776046 Common - Colicin V production protein Mfla_1693 53 COG1286 CvpA, Uncharacterized membrane protein, required for colicin V production General function prediction only 91775859 Common - malonyl CoA-acyl carrier protein transacylase Mfla_1506 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 91776987 Common - Tetratricopeptide TPR_2 Mfla_2639 51 COG3914 Spy, Predicted O-linked N-acetylglucosamine transferase, SPINDLY family Posttranslational modification, protein turnover, chaperones 91775042 Common - MxaA protein, putative Mfla_0689 9 None None None 91774717 Common - homoserine kinase Mfla_0361 71 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 91776794 Common mtgA monofunctional biosynthetic peptidoglycan transglycosylase Mfla_2444 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 91776489 Common - chorismate synthase Mfla_2137 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 91775595 Common - response regulator receiver domain protein (CheY-like) Mfla_1242 221 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 91775753 Common - 7-cyano-7-deazaguanine reductase Mfla_1400 102 COG0780 COG0780, Enzyme related to GTP cyclohydrolase I General function prediction only 91774653 Common - ribosomal protein L30 Mfla_0297 125 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 91775285 Common aat leucyl/phenylalanyl-tRNA--protein transferase Mfla_0932 134 COG2360 Aat, Leu/Phe-tRNA-protein transferase Posttranslational modification, protein turnover, chaperones 91774881 Nonpathogen - hypothetical protein Mfla_0526 1 None None None 91776581 Common - hypothetical protein Mfla_2229 4 None None None 91776442 Common - Lipid A export ATP-binding/permease protein MsbA Mfla_2090 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 91775463 Common - hypothetical protein Mfla_1110 10 None None None 91774867 Common - protein-export membrane protein SecD Mfla_0512 207 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 91774694 Common - Oxidoreductase alpha (molybdopterin) subunit Mfla_0338 180 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 91775524 Common - heat shock protein Hsp20 Mfla_1171 166 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 91777031 Common - hypothetical protein Mfla_2683 2 None None None 91775890 Nonpathogen - hypothetical protein Mfla_1537 1 None None None 91775769 Common - Malto-oligosyltrehalose synthase Mfla_1416 114 COG3280 TreY, Maltooligosyl trehalose synthase Carbohydrate transport and metabolism 91776631 Nonpathogen - protein of unknown function DUF1555 Mfla_2279 1 None None None 91775147 Common - Phosphate ABC transporter, permease protein PstC Mfla_0794 223 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 91776588 Common - hypothetical protein Mfla_2236 7 COG4701 COG4701, Uncharacterized protein conserved in bacteria Function unknown 91776913 Common - Homoserine O-acetyltransferase Mfla_2563 126 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 91775850 Common - TatD-related deoxyribonuclease Mfla_1497 237 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 91775902 Common - ABC transporter related Mfla_1549 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 91775017 Nonpathogen - hypothetical protein Mfla_0662 1 None None None 91774986 Nonpathogen - hypothetical protein Mfla_0631 2 None None None 91775141 Common - diacylglycerol kinase Mfla_0788 114 COG0818 DgkA, Diacylglycerol kinase Cell envelope biogenesis, outer membrane 91775955 Nonpathogen - protein of unknown function DUF1555 Mfla_1602 1 None None None 91774811 Common - Glutamate--ammonia ligase Mfla_0456 224 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 91775841 Common - hypothetical protein Mfla_1488 22 None None None 91776846 Common - rare lipoprotein A Mfla_2496 137 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 91774762 Common - hypothetical protein Mfla_0407 7 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 91774783 Common - flavodoxin/nitric oxide synthase Mfla_0428 83 COG0369 CysJ, Sulfite reductase, alpha subunit (flavoprotein) Inorganic ion transport and metabolism 91775909 Common - binding-protein-dependent transport systems inner membrane component Mfla_1556 163 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 91776035 Common - pyrroloquinoline quinone biosynthesis protein PqqC Mfla_1682 37 COG5424 COG5424, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C Coenzyme metabolism 91776451 Common - protein of unknown function DUF179 Mfla_2099 130 COG1678 COG1678, Putative transcriptional regulator Transcription 91775554 Common - major facilitator superfamily MFS_1 Mfla_1201 175 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 91776922 Common - Catalase-like protein Mfla_2572 128 COG0753 KatE, Catalase Inorganic ion transport and metabolism 91774677 Common - Nitrate transporter Mfla_0321 101 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 91775933 Common - hypothetical protein Mfla_1580 9 COG2457 COG2457, Uncharacterized conserved protein Function unknown 91776335 Common - flagellar protein FliS Mfla_1983 70 COG1516 FliS, Flagellin-specific chaperone FliS Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 91776725 Nonpathogen - hypothetical protein Mfla_2375 1 None None None 91774907 Common - Cytochrome-c peroxidase Mfla_0552 96 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 91775922 Common - NADPH-dependent FMN reductase Mfla_1569 60 COG0431 COG0431, Predicted flavoprotein General function prediction only 91774444 Nonpathogen - hypothetical protein Mfla_0088 2 None None None 91774372 Common - histone-like DNA-binding protein Mfla_0016 213 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 91775069 Common - two component transcriptional regulator, winged helix family Mfla_0716 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 91774673 Common - molybdopterin oxidoreductase Mfla_0317 199 COG0369 CysJ, Sulfite reductase, alpha subunit (flavoprotein) Inorganic ion transport and metabolism 91775385 Common - Ankyrin Mfla_1032 45 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 91774823 Common - phospholipid/glycerol acyltransferase Mfla_0468 118 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 91775329 Nonpathogen - hypothetical protein Mfla_0976 1 None None None 91775357 Common - GTP-binding protein LepA Mfla_1004 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 91776297 Common - flagellar biosynthesis protein FlhA Mfla_1945 127 COG1298 FlhA, Flagellar biosynthesis pathway, component FlhA Cell motility and secretion / Intracellular trafficking and secretion 91774711 Common - transcriptional regulator, TetR family Mfla_0355 84 COG1309 AcrR, Transcriptional regulator Transcription 91774705 Common - phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Mfla_0349 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 91775167 Common - signal transduction histidine kinase, glucose-6-phosphate specific Mfla_0814 156 COG3851 UhpB, Signal transduction histidine kinase, glucose-6-phosphate specific Signal transduction mechanisms 91776579 Common - hypothetical protein Mfla_2227 44 COG4582 COG4582, Uncharacterized protein conserved in bacteria Function unknown 91776403 Common - NADH-ubiquinone oxidoreductase, chain 4L Mfla_2051 161 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 91774544 Common - Peptidoglycan-binding LysM Mfla_0188 47 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 91774418 Common anmK anhydro-N-acetylmuramic acid kinase Mfla_0062 120 COG2377 COG2377, Predicted molecular chaperone distantly related to HSP70-fold metalloproteases Posttranslational modification, protein turnover, chaperones 91774405 Common - DNA-directed RNA polymerase, omega subunit Mfla_0049 115 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 91775972 Common - histidyl-tRNA synthetase Mfla_1619 248 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 91776785 Common - outer membrane efflux protein Mfla_2435 57 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91774379 Common - ribosomal protein L11 methyltransferase Mfla_0023 178 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 91776570 Common rpmA 50S ribosomal protein L27 Mfla_2218 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 91776806 Common - Shikimate kinase Mfla_2456 201 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 91775784 Nonpathogen - hypothetical protein Mfla_1431 1 None None None 91775049 Common ubiB putative ubiquinone biosynthesis protein UbiB Mfla_0696 185 COG0661 AarF, Predicted unusual protein kinase General function prediction only 91774878 Common - Drug resistance transporter EmrB/QacA subfamily Mfla_0523 170 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 91775616 Common - molybdopterin biosynthesis MoaE Mfla_1263 160 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 91776702 Common - binding-protein-dependent transport systems inner membrane component Mfla_2350 156 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 91774628 Common rpoB DNA-directed RNA polymerase subunit beta Mfla_0272 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 91775158 Common - co-chaperone Hsc20 Mfla_0805 56 COG1076 DjlA, DnaJ-domain-containing proteins 1 Posttranslational modification, protein turnover, chaperones 91776899 Nonpathogen - hypothetical protein Mfla_2549 1 None None None 91774735 Common - Peptidylprolyl isomerase Mfla_0379 146 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 91775557 Common - GTP-binding Mfla_1204 111 COG1161 COG1161, Predicted GTPases General function prediction only 91774804 Common - Outer membrane autotransporter barrel Mfla_0449 56 COG4625 COG4625, Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain Function unknown 91776577 Common - Prepilin peptidase Mfla_2225 147 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 91777044 Common - hypothetical protein Mfla_2696 21 None None None 91776933 Common - Fusaric acid resistance protein conserved region Mfla_2583 52 COG1289 COG1289, Predicted membrane protein Function unknown 91775122 Common - RfaE bifunctional protein, domain I Mfla_0769 156 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 91775548 Common - hypothetical protein Mfla_1195 48 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 91776088 Nonpathogen - hypothetical protein Mfla_1735 2 None None None 91775696 Common - General secretion pathway protein G Mfla_1343 92 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 91776011 Common - N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase Mfla_1658 27 COG3252 COG3252, Methenyltetrahydromethanopterin cyclohydrolase Coenzyme metabolism 91775702 Common - Hemolysin-type calcium-binding region Mfla_1349 70 COG2931 COG2931, RTX toxins and related Ca2+-binding proteins Secondary metabolites biosynthesis, transport, and catabolism 91775114 Common - Haloacid dehalogenase-like hydrolase Mfla_0761 13 COG0546 Gph, Predicted phosphatases General function prediction only 91774595 Common - Mammalian cell entry related Mfla_0239 93 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 91776888 Common - two component transcriptional regulator, winged helix family Mfla_2538 204 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 91775096 Common - acriflavin resistance protein Mfla_0743 186 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 91775151 Common - hypothetical protein Mfla_0798 22 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 91776247 Common - ATPase associated with various cellular activities, AAA_3 Mfla_1895 171 COG0714 COG0714, MoxR-like ATPases General function prediction only 91775688 Common - methylation Mfla_1335 13 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 91776183 Common - YceI Mfla_1831 117 COG2353 COG2353, Uncharacterized conserved protein Function unknown 91775949 Common - hypothetical protein Mfla_1596 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 91776611 Common - metal dependent phosphohydrolase Mfla_2259 208 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 91776510 Common proA gamma-glutamyl phosphate reductase Mfla_2158 187 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 91775336 Common - NolW-like protein Mfla_0983 11 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 91774832 Common - protein of unknown function DUF1568 Mfla_0477 57 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 91777002 Common - major facilitator superfamily MFS_1 Mfla_2654 62 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 91776392 Common - ATPase associated with various cellular activities, AAA_3 Mfla_2040 171 COG0714 COG0714, MoxR-like ATPases General function prediction only 91776890 Common - isochorismatase hydrolase Mfla_2540 114 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 91776055 Common - aspartate-semialdehyde dehydrogenase Mfla_1702 198 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 91774639 Common - ribosomal protein S19 Mfla_0283 243 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 91775589 Common - putative RNA methylase Mfla_1236 135 COG0116 COG0116, Predicted N6-adenine-specific DNA methylase DNA replication, recombination, and repair 91777074 Nonpathogen - hypothetical protein Mfla_2726 2 None None None 91776687 Common - ExsB Mfla_2335 178 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 91775822 Common - Squalene/phytoene synthase Mfla_1469 114 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 91774662 Common - magnesium transporter Mfla_0306 172 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 91776856 Common - histidine triad (HIT) protein Mfla_2506 55 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 91775912 Common - MotA/TolQ/ExbB proton channel Mfla_1559 143 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 91775349 Common - hypothetical protein Mfla_0996 10 COG4398 COG4398, Uncharacterized protein conserved in bacteria Function unknown 91774819 Nonpathogen - hypothetical protein Mfla_0464 1 None None None 91777102 Common - methyltransferase GidB Mfla_2754 205 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 91774364 Common - DNA-directed DNA polymerase Mfla_0008 185 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 91776267 Common - riboflavin biosynthesis protein RibD Mfla_1915 228 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 91775774 Common - phospholipase D/Transphosphatidylase Mfla_1421 86 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 91775294 Common - GCN5-related N-acetyltransferase Mfla_0941 110 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 91774947 Common - protein of unknown function DUF163 Mfla_0592 166 COG1576 COG1576, Uncharacterized conserved protein Function unknown 91776240 Common - succinyl-CoA synthetase, alpha subunit Mfla_1888 214 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 91774680 Common - hypothetical protein Mfla_0324 15 None None None 91776568 Common - gamma-glutamyl kinase Mfla_2216 194 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 91776565 Common - hypothetical protein Mfla_2213 14 None None None 91776071 Nonpathogen - protein of unknown function DUF1555 Mfla_1718 3 None None None 91774754 Nonpathogen - hypothetical protein Mfla_0398 1 None None None 91774743 Common - zinc/iron permease Mfla_0387 106 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 91776368 Common - glycosyl transferase, family 2 Mfla_2016 139 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 91775328 Common - bacteriophage replication gene A Mfla_0975 18 None None None 91776089 Common - response regulator receiver domain protein (CheY-like) Mfla_1736 158 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 91776303 Common - FlgN Mfla_1951 13 COG3418 COG3418, Flagellar biosynthesis/type III secretory pathway chaperone Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 91775743 Common - protein of unknown function DUF752 Mfla_1390 82 COG4121 COG4121, Uncharacterized conserved protein Function unknown 91776930 Common - transcriptional regulator, TetR family Mfla_2580 104 COG1309 AcrR, Transcriptional regulator Transcription 91776290 Nonpathogen - hypothetical protein Mfla_1938 4 None None None 91775148 Common - Phosphate binding protein Mfla_0795 149 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 91776542 Common - protein of unknown function UPF0047 Mfla_2190 136 COG0432 COG0432, Uncharacterized conserved protein Function unknown 91775204 Common - endonuclease III Mfla_0851 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 91775373 Common - TonB-like protein Mfla_1020 28 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 91776821 Common - anthranilate synthase component I Mfla_2471 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 91774793 Common - hypothetical protein Mfla_0438 113 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 91776661 Common - PhoH-like protein Mfla_2309 190 COG1875 COG1875, Predicted ATPase related to phosphate starvation-inducible protein PhoH Signal transduction mechanisms 91775036 Common - ABC transporter, permease protein, putative Mfla_0683 40 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 91775982 Nonpathogen - hypothetical protein Mfla_1629 3 None None None 91776744 Common - two component transcriptional regulator, winged helix family Mfla_2394 211 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 91774684 Nonpathogen - hypothetical protein Mfla_0328 1 None None None 91775678 Common - Glucose-6-phosphate isomerase Mfla_1325 192 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 91775568 Common - type I site-specific deoxyribonuclease, HsdR family Mfla_1215 137 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 91775188 Nonpathogen - hypothetical protein Mfla_0835 1 None None None 91776483 Common - exodeoxyribonuclease VII, small subunit Mfla_2131 120 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 91776945 Nonpathogen - hypothetical protein Mfla_2595 1 None None None 91776783 Common - hypothetical protein Mfla_2433 3 None None None 91776508 Common - Rare lipoprotein B Mfla_2156 46 COG2980 RlpB, Rare lipoprotein B Cell envelope biogenesis, outer membrane 91775482 Common - seryl-tRNA synthetase Mfla_1129 243 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 91775760 Common - cold-shock DNA-binding domain protein Mfla_1407 177 COG1278 CspC, Cold shock proteins Transcription 91776819 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) Mfla_2469 193 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 91776974 Common - diguanylate cyclase (GGDEF domain) Mfla_2626 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 91776952 Common - Carboxymethylenebutenolidase Mfla_2602 87 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 91776537 Common - protein-export protein SecB Mfla_2185 108 COG1952 SecB, Preprotein translocase subunit SecB Intracellular trafficking and secretion 91775406 Nonpathogen - hypothetical protein Mfla_1053 1 None None None 91775265 Nonpathogen - hypothetical protein Mfla_0912 1 None None None 91776900 Common - Heavy metal translocating P-type ATPase Mfla_2550 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 91775306 Common - ATP-dependent DNA helicase RecQ Mfla_0953 226 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 91776169 Common - bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase Mfla_1817 218 COG1049 AcnB, Aconitase B Energy production and conversion 91775628 Common - glycosyl transferase, group 1 Mfla_1275 187 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 91776976 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC and GAF sensor(s) Mfla_2628 198 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 91774475 Common - CobB/CobQ-like glutamine amidotransferase Mfla_0119 136 COG1797 CobB, Cobyrinic acid a,c-diamide synthase Coenzyme metabolism 91775656 Common - putative GNAT-family acetyltransferase Mfla_1303 91 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 91776191 Common - transglutaminase-like protein Mfla_1839 103 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 91776138 Common - Na+/solute symporter Mfla_1786 66 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 91776301 Common - MotA/TolQ/ExbB proton channel Mfla_1949 87 COG1291 MotA, Flagellar motor component Cell motility and secretion 91774467 Common - hypothetical protein Mfla_0111 13 None None None 91775210 Common - hypothetical protein Mfla_0857 20 COG3073 RseA, Negative regulator of sigma E activity Signal transduction mechanisms 91775803 Common - cytochrome c, class I Mfla_1450 36 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 91774566 Common - blue (type 1) copper domain Mfla_0210 17 COG3241 COG3241, Azurin Energy production and conversion 91775719 Nonpathogen - hypothetical protein Mfla_1366 1 None None None 91774981 Common - branched-chain amino acid aminotransferase Mfla_0626 219 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 91776124 Common - ABC transporter related Mfla_1771 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 91776308 Common - flagellar hook capping protein Mfla_1956 115 COG1843 FlgD, Flagellar hook capping protein Cell motility and secretion 91775552 Common - ABC transporter related Mfla_1199 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 91774897 Common - twin-arginine translocation protein, TatA/E family Mfla_0542 80 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 91775453 Common - hypothetical protein Mfla_1100 8 None None None 91775895 Common - binding-protein-dependent transport systems inner membrane component Mfla_1542 219 COG4174 COG4174, ABC-type uncharacterized transport system, permease component General function prediction only 91774954 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Mfla_0599 201 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 91776340 Common - putative signal transduction histidine kinase Mfla_1988 150 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 91775366 Nonpathogen - hypothetical protein Mfla_1013 1 None None None 91775940 Common - HflK protein Mfla_1587 162 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 91775195 Common - uncharacterized lipoprotein Mfla_0842 33 COG3317 NlpB, Uncharacterized lipoprotein Cell envelope biogenesis, outer membrane 91775056 Common - hypothetical protein Mfla_0703 21 COG3495 COG3495, Uncharacterized protein conserved in bacteria Function unknown 91775686 Common - hypothetical protein Mfla_1333 11 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 91777096 Common - ATP synthase F0, B subunit Mfla_2748 159 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 91774602 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase Mfla_0246 210 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 91775667 Common - phage integrase Mfla_1314 176 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 91776424 Common - Class I peptide chain release factor Mfla_2072 111 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 91776980 Common - transcriptional regulator, LysR family Mfla_2632 181 COG0583 LysR, Transcriptional regulator Transcription 91776105 Common - hypothetical protein Mfla_1752 24 COG3893 COG3893, Inactivated superfamily I helicase DNA replication, recombination, and repair 91775673 Common - excinuclease ABC subunit B Mfla_1320 227 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 91774574 Nonpathogen - putative transmembrane protein Mfla_0218 1 None None None 91776357 Nonpathogen - hypothetical protein Mfla_2005 1 None None None 91774455 Common - cobalamin 5'-phosphate synthase Mfla_0099 131 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 91776765 Common - putative prolin-rich transmembrane protein Mfla_2415 7 None None None 91775480 Common - hypothetical protein Mfla_1127 17 COG4254 COG4254, Uncharacterized protein conserved in bacteria Function unknown 91774499 Common - sigma 54 modulation protein/ribosomal protein S30EA Mfla_0143 126 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 91775505 Nonpathogen - hypothetical protein Mfla_1152 1 None None None 91774722 Nonpathogen - hypothetical protein Mfla_0366 1 None None None 91774465 Common - TonB-dependent siderophore receptor Mfla_0109 115 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 91776058 Common - isopropylmalate isomerase large subunit Mfla_1705 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 91777082 Common - Glutamate synthase (NADPH) Mfla_2734 202 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 91774942 Common - transcriptional regulator, AraC family Mfla_0587 120 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 91776966 Common - hypothetical protein Mfla_2617 90 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 91776415 Nonpathogen secG preprotein translocase subunit SecG Mfla_2063 5 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 91777066 Nonpathogen - hypothetical protein Mfla_2718 1 None None None 91776593 Common - protein of unknown function DUF1232 Mfla_2241 40 COG3339 COG3339, Uncharacterized conserved protein Function unknown 91776316 Common flgL flagellar hook-associated protein FlgL Mfla_1964 97 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 91775700 Common - Type I secretion system ATPase, PrtD Mfla_1347 249 COG4618 ArpD, ABC-type protease/lipase transport system, ATPase and permease components General function prediction only 91776325 Common - flagellar hook-length control protein Mfla_1973 44 COG3144 FliK, Flagellar hook-length control protein Cell motility and secretion 91776525 Common - Rubredoxin-type Fe(Cys)4 protein Mfla_2173 205 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 91776278 Common - cyclic nucleotide-binding domain (cNMP-BD) protein Mfla_1926 68 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 91776942 Common - transcriptional regulator, LysR family Mfla_2592 178 COG0583 LysR, Transcriptional regulator Transcription 91775971 Common - ABC transporter related Mfla_1618 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 91776613 Common - Lytic transglycosylase, catalytic Mfla_2261 158 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 91775257 Common - homoserine dehydrogenase Mfla_0904 217 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 91774716 Common - hypothetical protein Mfla_0360 11 None None None 91776417 Common - single-stranded-DNA-specific exonuclease RecJ Mfla_2065 192 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 91776776 Common - excinuclease ABC, A subunit Mfla_2426 237 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 91774977 Common - hypothetical protein Mfla_0622 18 None None None 91775172 Nonpathogen - hypothetical protein Mfla_0819 1 None None None 91777079 Nonpathogen - hypothetical protein Mfla_2731 1 None None None 91775543 Nonpathogen - hypothetical protein Mfla_1190 1 None None None 91776200 Common - binding-protein-dependent transport systems inner membrane component Mfla_1848 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 91777054 Nonpathogen - bacteriophage lysis protein Mfla_2706 1 None None None 91774555 Common - molybdenum cofactor biosynthesis protein C Mfla_0199 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 91776224 Common - Pseudouridine synthase, Rsu Mfla_1872 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 91775375 Common - Biopolymer transport protein ExbD/TolR Mfla_1022 130 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 91774620 Common - Stringent starvation protein B Mfla_0264 64 COG2969 SspB, Stringent starvation protein B General function prediction only 91775229 Common - TonB-like protein Mfla_0876 28 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 91775215 Common - putative transmembrane protein Mfla_0862 17 None None None 91776657 Common - beta-lactamase-like protein Mfla_2305 89 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 91774516 Common - YaeQ Mfla_0160 52 COG4681 COG4681, Uncharacterized protein conserved in bacteria Function unknown 91775660 Common - two component transcriptional regulator, winged helix family Mfla_1307 221 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 91774985 Common - cytochrome c oxidase, cbb3-type, subunit II Mfla_0630 82 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 91775224 Nonpathogen - hypothetical protein Mfla_0871 4 None None None 91774772 Common - protein of unknown function DUF477 Mfla_0417 54 COG3762 COG3762, Predicted membrane protein Function unknown 91775494 Common - inosine-5'-monophosphate dehydrogenase Mfla_1141 241 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 91776137 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase Mfla_1785 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 91774729 Common - Hydrophobe/amphiphile efflux-1 HAE1 Mfla_0373 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 91774619 Common - glutathione S-transferase-like protein Mfla_0263 116 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 91776231 Common - YCII-related Mfla_1879 73 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 91776646 Common - molybdenum cofactor synthesis-like protein Mfla_2294 201 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 91775276 Common - orotidine 5'-phosphate decarboxylase Mfla_0923 169 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 91775772 Common - alpha amylase, catalytic region Mfla_1419 93 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 91775442 Common - two component transcriptional regulator, LuxR family Mfla_1089 224 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 91774534 Common - hypothetical protein Mfla_0178 5 COG3895 COG3895, Predicted periplasmic protein General function prediction only 91774398 Common - Ham1-like protein Mfla_0042 237 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 91776425 Common - Leucyl aminopeptidase Mfla_2073 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 91775984 Common - hypothetical protein Mfla_1631 8 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 91775243 Nonpathogen - hypothetical protein Mfla_0890 1 None None None 91776033 Common - pyrroloquinoline quinone biosynthesis protein PqqE Mfla_1680 158 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 91776700 Common - extracellular solute-binding protein, family 1 Mfla_2348 98 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 161611348 Common slmA nucleoid occlusion protein Mfla_2257 49 COG1309 AcrR, Transcriptional regulator Transcription 91775910 Common - binding-protein-dependent transport systems inner membrane component Mfla_1557 194 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 91776027 Common - Sulfate adenylyltransferase, large subunit Mfla_1674 249 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 91775448 Common - Lipocalin-like protein Mfla_1095 67 COG3040 Blc, Bacterial lipocalin Cell envelope biogenesis, outer membrane 91774448 Common - protein of unknown function UPF0187 Mfla_0092 56 COG3781 COG3781, Predicted membrane protein Function unknown 91776024 Common - nitrite and sulphite reductase 4Fe-4S region Mfla_1671 165 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 91774610 Common - imidazoleglycerol phosphate synthase, cyclase subunit Mfla_0254 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 91776684 Common - tRNA (guanine-N1)-methyltransferase Mfla_2332 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 91776665 Common - extracellular solute-binding protein, family 3 Mfla_2313 18 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 91776691 Common - TolB-like protein Mfla_2339 164 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 91774647 Common rplE 50S ribosomal protein L5 Mfla_0291 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 91774360 Nonpathogen - hypothetical protein Mfla_0004 1 None None None 91775235 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Mfla_0882 21 None None None 91776493 Common - type II secretion system protein E Mfla_2141 218 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 91776061 Common - argininosuccinate synthase Mfla_1708 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 91776851 Common - lipoyl synthase Mfla_2501 191 COG0320 LipA, Lipoate synthase Coenzyme metabolism 91774586 Common - protein of unknown function DUF185 Mfla_0230 94 COG1565 COG1565, Uncharacterized conserved protein Function unknown 91775021 Nonpathogen - hypothetical protein Mfla_0666 1 None None None 91775963 Common - Cupin 2, conserved barrel Mfla_1610 20 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 91776238 Common - NAD+ synthetase Mfla_1886 224 COG0171 NadE, NAD synthase Coenzyme metabolism 91775815 Nonpathogen - hypothetical protein Mfla_1462 1 None None None 91775603 Common - Arylesterase Mfla_1250 105 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 91776284 Common - MCP methyltransferase, CheR-type Mfla_1932 150 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 91774383 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Mfla_0027 169 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 91776752 Common - Biopolymer transport protein ExbD/TolR Mfla_2402 134 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 91776624 Common - phospho-N-acetylmuramoyl-pentapeptide-transferase Mfla_2272 221 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 91776698 Common - transcriptional regulator, LacI family Mfla_2346 126 COG1609 PurR, Transcriptional regulators Transcription 91776094 Nonpathogen - hypothetical protein Mfla_1741 1 None None None 91775099 Common - Alpha/beta hydrolase fold-3 Mfla_0746 133 COG0657 Aes, Esterase/lipase Lipid metabolism 91775846 Common - transcriptional regulator, ArsR family Mfla_1493 142 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 91775978 Common - RNA methyltransferase TrmH, group 3 Mfla_1625 215 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 91775312 Common - Secretion chaperone CsaA Mfla_0959 104 COG0073 ARC1, EMAP domain General function prediction only 91775882 Common tsf elongation factor Ts Mfla_1529 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 91776153 Common - NAD-dependent epimerase/dehydratase Mfla_1801 77 COG2910 COG2910, Putative NADH-flavin reductase General function prediction only 91776796 Common - Rhodanese-like protein Mfla_2446 37 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 91776116 Common - HupE/UreJ protein Mfla_1763 48 COG2370 HupE, Hydrogenase/urease accessory protein Posttranslational modification, protein turnover, chaperones 91777041 Common - hypothetical protein Mfla_2693 4 None None None 91775472 Common - thioredoxin reductase Mfla_1119 248 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 91774658 Common rpsM 30S ribosomal protein S13 Mfla_0302 246 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 91774486 Common - phosphate uptake regulator, PhoU Mfla_0130 199 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 91777003 Common - response regulator receiver (CheY-like) modulated metal dependent phosphohydrolase Mfla_2655 219 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 91775993 Common - type II secretion system protein E Mfla_1640 223 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 91775630 Common - sugar transferase Mfla_1277 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 91776713 Common - Potassium efflux system protein Mfla_2361 202 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 91775451 Common - DEAD/DEAH box helicase-like protein Mfla_1098 236 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 91776215 Common - exodeoxyribonuclease VII, large subunit Mfla_1863 205 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 91776497 Common - Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family Mfla_2145 126 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 91775135 Common - ribosomal RNA methyltransferase RrmJ/FtsJ Mfla_0782 138 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 91775461 Common - Hsp33 protein Mfla_1108 132 COG1281 COG1281, Disulfide bond chaperones of the HSP33 family Posttranslational modification, protein turnover, chaperones 91774481 Common - hypothetical protein Mfla_0125 42 COG3651 COG3651, Uncharacterized protein conserved in bacteria Function unknown 91775606 Common - TonB-dependent receptor Mfla_1253 98 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 91776527 Common - OsmC-like protein Mfla_2175 19 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 91775072 Common - formate dehydrogenase family accessory protein FdhD Mfla_0719 137 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 91776141 Common - luciferase-like protein Mfla_1789 115 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 91776210 Common - binding-protein-dependent transport systems inner membrane component Mfla_1858 185 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 91775575 Common - thioredoxin-related Mfla_1222 34 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 91776539 Common - Rhodanese-like protein Mfla_2187 135 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 91776675 Common - DNA primase Mfla_2323 216 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 91774847 Common - Riboflavin synthase Mfla_0492 229 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 91775028 Common - translation-associated GTPase Mfla_0675 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 91774525 Common - RND efflux system, outer membrane lipoprotein, NodT Mfla_0169 113 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91776362 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Mfla_2010 166 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 91776472 Common - acetolactate synthase, small subunit Mfla_2120 190 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 91775988 Common - membrane protein-like protein Mfla_1635 17 COG4655 COG4655, Predicted membrane protein Function unknown 91774949 Common - aspartate alpha-decarboxylase Mfla_0594 130 COG0853 PanD, Aspartate 1-decarboxylase Coenzyme metabolism 91775833 Common - Methyltransferase type 11 Mfla_1480 62 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 91776173 Common - protein of unknown function DUF490 Mfla_1821 106 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 91776257 Common - TonB-dependent receptor Mfla_1905 97 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 91775794 Common - Alcohol dehydrogenase GroES-like protein Mfla_1441 199 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 91776968 Common - Twin-arginine translocation pathway signal Mfla_2619 107 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 91775659 Common - Heavy metal efflux pump CzcA Mfla_1306 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 91776142 Common - transcriptional regulator, LysR family Mfla_1790 124 COG0583 LysR, Transcriptional regulator Transcription 91774506 Common - Oligopeptidase A Mfla_0150 125 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 91776802 Common - DNA polymerase, beta-like region Mfla_2452 15 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 91775722 Common - glycoside hydrolase, family 57 Mfla_1369 33 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 91776465 Common - maf protein Mfla_2113 199 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 91776311 Common - Flagellar basal-body rod FlgG Mfla_1959 126 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 91775425 Common - cytidylate kinase Mfla_1072 204 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 91776318 Common - flagellar biosynthetic protein FliR Mfla_1966 115 COG1684 FliR, Flagellar biosynthesis pathway, component FliR Cell motility and secretion / Intracellular trafficking and secretion 91776382 Nonpathogen - Abortive infection protein Mfla_2030 10 None None None 91775346 Common - hypothetical protein Mfla_0993 11 None None None 91775478 Common - outer membrane lipoprotein carrier protein LolA Mfla_1125 90 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 91775613 Common - TPR repeat Mfla_1260 168 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 91776989 Common - acyl carrier protein Mfla_2641 4 None None None 91776992 Common - short-chain dehydrogenase/reductase SDR Mfla_2644 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 91776732 Common ntpA dATP pyrophosphohydrolase Mfla_2382 37 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 91774769 Common - phage SPO1 DNA polymerase-related protein Mfla_0414 158 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 91775171 Common - TonB-dependent receptor, plug Mfla_0818 110 COG4772 FecA, Outer membrane receptor for Fe3+-dicitrate Inorganic ion transport and metabolism 91775694 Common - type II secretion system protein E Mfla_1341 218 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 91776817 Common - anthranilate phosphoribosyltransferase Mfla_2467 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 91776723 Common - RND efflux system, outer membrane lipoprotein, NodT Mfla_2371 118 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91774817 Common - chain B, amide receptor of the amidase operon (Amic) Mfla_0462 98 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 91776823 Common - Shikimate/quinate 5-dehydrogenase Mfla_2473 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 91775098 Common - RND efflux system, outer membrane lipoprotein, NodT Mfla_0745 121 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91775920 Common - sigma-54 factor, interaction region Mfla_1567 169 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 91774708 Common - methyl-accepting chemotaxis sensory transducer Mfla_0352 151 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 91775355 Common - sigma E regulatory protein, MucB/RseB Mfla_1002 48 COG3026 RseB, Negative regulator of sigma E activity Signal transduction mechanisms 91776197 Common - beta-hexosaminidase Mfla_1845 177 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 91776961 Common - MscS Mechanosensitive ion channel Mfla_2612 131 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 91775038 Nonpathogen - hypothetical protein Mfla_0685 4 None None None 91775939 Common - HflC protein Mfla_1586 208 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 91776563 Common rpsT 30S ribosomal protein S20 Mfla_2211 135 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 91776236 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Mfla_1884 35 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 91775023 Nonpathogen - hypothetical protein Mfla_0668 1 None None None 91775738 Common - tRNA delta(2)-isopentenylpyrophosphate transferase Mfla_1385 214 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 91775622 Common - ABC-2 Mfla_1269 114 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 91776911 Common - NLPA lipoprotein Mfla_2561 113 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 91775919 Common - class II aldolase/adducin-like protein Mfla_1566 11 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 91774807 Common - FAD dependent oxidoreductase Mfla_0452 131 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 91776006 Common - sugar isomerase (SIS) Mfla_1653 70 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 91775384 Common - phosphoribosylformylglycinamidine synthase Mfla_1031 232 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 91775680 Common - single-strand binding protein/Primosomal replication protein n Mfla_1327 45 COG2965 PriB, Primosomal replication protein N DNA replication, recombination, and repair 91776470 Common - type II secretion system protein E Mfla_2118 170 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 91775888 Common - Alkanesulfonate monooxygenase Mfla_1535 64 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 91775161 Common - cysteine desulfurase IscS Mfla_0808 240 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 91775060 Common - zinc/iron permease Mfla_0707 85 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 91776839 Common - glutamyl-tRNA(Gln) amidotransferase, A subunit Mfla_2489 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 91775102 Common - Drug resistance transporter Bcr/CflA subfamily Mfla_0749 220 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 91775974 Common - hypothetical protein Mfla_1621 91 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 91774856 Nonpathogen - hypothetical protein Mfla_0501 1 None None None 91774733 Common - adenosylmethionine-8-amino-7-oxononanoate aminotransferase Mfla_0377 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 91776833 Common - major facilitator superfamily MFS_1 Mfla_2483 109 None None None 91775326 Nonpathogen - hypothetical protein Mfla_0973 1 None None None 91776553 Common - periplasmic sensor signal transduction histidine kinase Mfla_2201 167 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 91774403 Common - protein of unknown function DUF475 Mfla_0047 41 COG2899 COG2899, Uncharacterized protein conserved in bacteria Function unknown 91774913 Common - DNA topoisomerase, type I, putative Mfla_0558 45 COG3569 COG3569, Topoisomerase IB DNA replication, recombination, and repair 91776043 Common - hypothetical protein Mfla_1690 23 None None None 91776925 Common - transcriptional regulator, LysR family Mfla_2575 118 COG0583 LysR, Transcriptional regulator Transcription 91775010 Nonpathogen - putative signal transduction protein with EFhand domain Mfla_0655 1 COG5126 FRQ1, Ca2+-binding protein (EF-Hand superfamily) Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only 91775953 Nonpathogen - hypothetical protein Mfla_1600 3 None None None 91775112 Common - phosphogluconate dehydratase Mfla_0759 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 91775109 Common - hypothetical protein Mfla_0756 65 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 91774696 Common - dihydroxy-acid dehydratase Mfla_0340 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 91775040 Common - ATPase associated with various cellular activities, AAA_3 Mfla_0687 176 COG0714 COG0714, MoxR-like ATPases General function prediction only 91775394 Common - hypothetical protein Mfla_1041 32 COG3497 COG3497, Phage tail sheath protein FI General function prediction only 91775662 Common - Integrase, catalytic region Mfla_1309 129 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 91775465 Common - hypothetical protein Mfla_1112 2 None None None 91774359 Common - DNA gyrase, B subunit Mfla_0003 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 91775444 Nonpathogen - protein of unknown function DUF1328 Mfla_1091 1 None None None 91774921 Nonpathogen - hypothetical protein Mfla_0566 1 None None None 91775031 Common - ribose-phosphate pyrophosphokinase Mfla_0678 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 91776163 Common - protein of unknown function DUF395, YeeE/YedE Mfla_1811 71 COG2391 COG2391, Predicted transporter component General function prediction only 91775047 Common - Co/Zn/Cd efflux system component Mfla_0694 127 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 91776763 Common - methylation Mfla_2413 14 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 91774869 Common - queuine tRNA-ribosyltransferase Mfla_0514 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 91775019 Nonpathogen - hypothetical protein Mfla_0664 1 None None None 91776079 Common - Glutamate-ammonia-ligase adenylyltransferase Mfla_1726 119 COG1391 GlnE, Glutamine synthetase adenylyltransferase Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms 91775759 Common - Conserved TM helix Mfla_1406 35 None None None 91776863 Common - nitrogen regulatory protein P-II (GlnB, GlnK) Mfla_2513 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 91776444 Common - MotA/TolQ/ExbB proton channel Mfla_2092 150 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 91774416 Common - HesB/YadR/YfhF Mfla_0060 166 COG0316 IscA, Uncharacterized conserved protein Function unknown 91777011 Common - thiamine-phosphate pyrophosphorylase Mfla_2663 188 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 91775699 Common - Type I secretion membrane fusion protein, HlyD Mfla_1346 120 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 91774723 Nonpathogen - hypothetical protein Mfla_0367 1 None None None 91775539 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Mfla_1186 228 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 91776915 Nonpathogen - hypothetical protein Mfla_2565 1 None None None 91774568 Common - secretion protein HlyD Mfla_0212 165 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 91776121 Common - urease, beta subunit Mfla_1768 96 COG0832 UreB, Urea amidohydrolase (urease) beta subunit Amino acid transport and metabolism 91775767 Nonpathogen - hypothetical protein Mfla_1414 1 None None None 91774627 Common - ribosomal protein L7/L12 Mfla_0271 214 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 91775526 Common - phospholipase D/Transphosphatidylase Mfla_1173 4 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 91775995 Common - type II and III secretion system protein Mfla_1642 139 COG4964 CpaC, Flp pilus assembly protein, secretin CpaC Intracellular trafficking and secretion 91775565 Common - ATP-dependent helicase HrpA Mfla_1212 131 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 91776251 Nonpathogen - hypothetical protein Mfla_1899 4 None None None 91775857 Common - acyl carrier protein Mfla_1504 179 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 91774675 Common - Nitrite reductase (NAD(P)H) large subunit, NirB Mfla_0319 201 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 91776633 Common - Protein of unknown function UPF0011 Mfla_2281 208 COG0313 COG0313, Predicted methyltransferases General function prediction only 91775283 Common - Prephenate dehydrogenase Mfla_0930 171 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 91776519 Common - protein of unknown function DUF81 Mfla_2167 17 COG0730 COG0730, Predicted permeases General function prediction only 91776746 Nonpathogen - protein of unknown function DUF1555 Mfla_2396 3 None None None 91776781 Common - hydroxymethylbutenyl pyrophosphate reductase Mfla_2431 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 91774946 Common - Deoxyribodipyrimidine photolyase Mfla_0591 136 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 91776705 Common - Holliday junction DNA helicase RuvA Mfla_2353 210 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 91774442 Common - band 7 protein Mfla_0086 216 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 91776880 Common - thiamine biosynthesis protein ThiC Mfla_2530 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 91775751 Common - hypothetical protein Mfla_1398 9 None None None 91775129 Common - SmpA/OmlA Mfla_0776 63 COG2913 SmpA, Small protein A (tmRNA-binding) Translation, ribosomal structure and biogenesis 91775191 Common - Cupin 4 Mfla_0838 58 COG2850 COG2850, Uncharacterized conserved protein Function unknown 91776999 Common - CsbD-like protein Mfla_2651 55 COG3237 COG3237, Uncharacterized protein conserved in bacteria Function unknown 91776361 Common - glucose-1-phosphate thymidylyltransferase Mfla_2009 233 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 91774524 Common - secretion protein HlyD Mfla_0168 113 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 91776305 Common - Flageller protein FlgA Mfla_1953 45 COG1261 FlgA, Flagellar basal body P-ring biosynthesis protein Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 91774421 Common - protein of unknown function DUF150 Mfla_0065 163 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 91775899 Common - thermophilic desulfurizing enzyme, TdsB protein Mfla_1546 13 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 91777023 Common - DSBA oxidoreductase Mfla_2675 58 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 91776648 Common - molybdopterin-guanine dinucleotide biosynthesis protein B Mfla_2296 84 COG1763 MobB, Molybdopterin-guanine dinucleotide biosynthesis protein Coenzyme metabolism 91775186 Common - TonB-dependent receptor Mfla_0833 73 COG4772 FecA, Outer membrane receptor for Fe3+-dicitrate Inorganic ion transport and metabolism 91776674 Common - sigma 70 (RpoD) Mfla_2322 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 91774781 Common - hypothetical protein Mfla_0426 25 COG5266 CbiK, ABC-type Co2+ transport system, periplasmic component Inorganic ion transport and metabolism 91775245 Common - hypothetical protein Mfla_0892 15 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 91775676 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Mfla_1323 182 COG0546 Gph, Predicted phosphatases General function prediction only 91776488 Common - major facilitator superfamily MFS_1 Mfla_2136 79 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 91774451 Common - TonB-dependent siderophore receptor Mfla_0095 100 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 91776954 Common - N-6 DNA methylase Mfla_2604 155 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 91776841 Common - cell shape determining protein, MreB/Mrl family Mfla_2491 236 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 91776559 Common - lipoprotein signal peptidase Mfla_2207 100 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91774969 Common - Thiosulphate-binding protein Mfla_0614 89 COG1613 Sbp, ABC-type sulfate transport system, periplasmic component Inorganic ion transport and metabolism 91777013 Common - hypothetical protein Mfla_2665 19 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 91774546 Common - protein of unknown function DUF494 Mfla_0190 41 COG2922 Smg, Uncharacterized protein conserved in bacteria Function unknown 91775805 Common - MscS Mechanosensitive ion channel Mfla_1452 203 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 91775496 Common - protein of unknown function UPF0125 Mfla_1143 68 COG2914 COG2914, Uncharacterized protein conserved in bacteria Function unknown 91775152 Common - sulphate transporter Mfla_0799 158 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 91775730 Common - glycosyl transferase, family 2 Mfla_1377 210 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 91774876 Common - cytochrome c assembly protein Mfla_0521 84 COG4137 COG4137, ABC-type uncharacterized transport system, permease component General function prediction only 91776535 Common - Glycerol-3-phosphate dehydrogenase (NAD(P)+) Mfla_2183 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 91776972 Nonpathogen - VanZ like protein Mfla_2623 1 COG5652 COG5652, Predicted integral membrane protein Function unknown 91775516 Common - hypothetical protein Mfla_1163 40 COG3247 HdeD, Uncharacterized conserved protein Function unknown 91776607 Common - acetylglutamate kinase Mfla_2255 219 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 91776481 Common - adenylate/guanylate cyclase Mfla_2129 91 COG4252 COG4252, Predicted transmembrane sensor domain Signal transduction mechanisms 91776187 Common - transcriptional regulator, LysR family Mfla_1835 90 COG0583 LysR, Transcriptional regulator Transcription 91776295 Common - transcriptional activator FlhD Mfla_1943 27 None None None 91776602 Common - hypothetical protein Mfla_2250 60 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 91774597 Common - STAS domain Mfla_0241 5 COG3113 COG3113, Predicted NTP binding protein (contains STAS domain) General function prediction only 91774883 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) Mfla_0528 184 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 91774988 Common - 4Fe-4S ferredoxin, iron-sulfur binding Mfla_0633 78 COG0348 NapH, Polyferredoxin Energy production and conversion 91776119 Common - UreE urease accessory-like protein Mfla_1766 67 COG2371 UreE, Urease accessory protein UreE Posttranslational modification, protein turnover, chaperones 91775369 Common - TonB-dependent receptor Mfla_1016 97 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 91776067 Common - two component transcriptional regulator, LuxR family Mfla_1714 223 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 91774559 Common - Alcohol dehydrogenase, zinc-binding Mfla_0203 214 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 91776566 Common - phosphoribosylaminoimidazole carboxylase ATPase subunit Mfla_2214 195 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 91777086 Common - periplasmic sensor signal transduction histidine kinase Mfla_2738 213 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 91774834 Common - putative transmembrane protein Mfla_0479 3 None None None 91776741 Common - ABC transporter related Mfla_2391 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 91776897 Common - IstB-like ATP-binding protein Mfla_2547 92 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 91775004 Common - protein of unknown function UPF0054 Mfla_0649 206 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 91776476 Common - 40-residue YVTN beta-propeller repeat Mfla_2124 98 COG3391 COG3391, Uncharacterized conserved protein Function unknown 91776269 Common - Glycine hydroxymethyltransferase Mfla_1917 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 91776388 Nonpathogen - hypothetical protein Mfla_2036 4 None None None 91776598 Common - hypothetical protein Mfla_2246 6 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 91776878 Common - hypothetical protein Mfla_2528 24 COG3753 COG3753, Uncharacterized protein conserved in bacteria Function unknown 91775428 Common - arginyl-tRNA-protein transferase Mfla_1075 85 COG2935 COG2935, Putative arginyl-tRNA:protein arginylyltransferase Posttranslational modification, protein turnover, chaperones 91775801 Common - Cytochrome-c oxidase Mfla_1448 175 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 91775845 Common - Arsenical resistance operon trans-acting repressor ArsD Mfla_1492 31 None None None 91776512 Common - dethiobiotin synthase Mfla_2160 168 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 91776692 Common - hypothetical protein Mfla_2340 13 COG5373 COG5373, Predicted membrane protein Function unknown 91776110 Common - ammonium transporter Mfla_1757 201 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 91776804 Common - deoxyguanosinetriphosphate triphosphohydrolase-like protein Mfla_2454 160 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 91777072 Common - histone-like DNA-binding protein Mfla_2724 201 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 91776909 Common - binding-protein-dependent transport systems inner membrane component Mfla_2559 201 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 91776886 Common - Three-deoxy-D-manno-octulosonic-acid transferase-like protein Mfla_2536 128 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 91775817 Nonpathogen - hypothetical protein Mfla_1464 1 None None None 91776663 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Mfla_2311 211 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 91775776 Common - hypothetical protein Mfla_1423 8 None None None 91777109 Common - ribosomal protein L34 Mfla_2761 8 COG0230 RpmH, Ribosomal protein L34 Translation, ribosomal structure and biogenesis 91776572 Common - Trans-hexaprenyltranstransferase Mfla_2220 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 91774732 Nonpathogen - hypothetical protein Mfla_0376 3 None None None 91776854 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding Mfla_2504 60 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 91774614 Common - twin-arginine translocation protein, TatA/E family Mfla_0258 84 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 91775587 Common - ribonuclease II Mfla_1234 84 COG0557 VacB, Exoribonuclease R Transcription 91776242 Common - phosphoserine phosphatase SerB Mfla_1890 154 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 91774935 Common - putative monovalent cation/H+ antiporter subunit D Mfla_0580 156 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 91775296 Common - cytochrome bd ubiquinol oxidase, subunit I Mfla_0943 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 91776212 Common - hypothetical protein Mfla_1860 10 None None None 91776260 Common - Septum formation initiator Mfla_1908 64 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 91776249 Common - hypothetical protein Mfla_1897 7 None None None 91776832 Common - hypothetical protein Mfla_2482 56 COG2836 COG2836, Uncharacterized conserved protein Function unknown 91775198 Common - protein of unknown function UPF0227 Mfla_0845 46 COG3150 COG3150, Predicted esterase General function prediction only 91775274 Common metG methionyl-tRNA synthetase Mfla_0921 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 91775240 Common - phosphoribosylformylglycinamidine synthase Mfla_0887 232 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 91775545 Common - ABC transporter related Mfla_1192 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 91774434 Common - type II secretion system protein E Mfla_0078 213 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 91774699 Common - sigma54 specific transcriptional regulator with GAF sensor, Fis family Mfla_0343 177 COG3284 AcoR, Transcriptional activator of acetoin/glycerol metabolism Secondary metabolites biosynthesis, transport, and catabolism / Transcription 91777005 Common - enoyl-CoA hydratase Mfla_2657 143 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 91776177 Common - protein-L-isoaspartate O-methyltransferase Mfla_1825 155 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 91776051 Common - tryptophan synthase subunit beta Mfla_1698 228 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 91775118 Common - hypothetical protein Mfla_0765 7 None None None 91776756 Common - hemolysin activation/secretion protein Mfla_2406 60 COG2831 FhaC, Hemolysin activation/secretion protein Intracellular trafficking and secretion 91776406 Common - respiratory-chain NADH dehydrogenase, subunit 1 Mfla_2054 188 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 91775111 Common - Carbamoyltransferase Mfla_0758 52 COG2192 COG2192, Predicted carbamoyl transferase, NodU family Posttranslational modification, protein turnover, chaperones 91776672 Nonpathogen - hypothetical protein Mfla_2320 1 None None None 91775259 Common - Thymidylate synthase Mfla_0906 141 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 91775212 Common - Peptidase S1C, Do Mfla_0859 224 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 91775206 Common - Phosphomethylpyrimidine kinase Mfla_0853 219 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 91776778 Common - hypothetical protein Mfla_2428 11 COG3204 COG3204, Uncharacterized protein conserved in bacteria Function unknown 91774756 Common - aldo/keto reductase Mfla_0400 197 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 91774366 Common - transport-associated Mfla_0010 37 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 91775174 Common - glycoside hydrolase, family 24 Mfla_0821 51 COG3772 COG3772, Phage-related lysozyme (muraminidase) General function prediction only 91777052 Nonpathogen - hypothetical protein Mfla_2704 1 None None None 91776202 Common - extracellular solute-binding protein, family 5 Mfla_1850 194 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 91776314 Common - Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase Mfla_1962 69 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 91776022 Common - transcriptional regulator CysB-like protein Mfla_1669 192 COG0583 LysR, Transcriptional regulator Transcription 91776333 Common - hypothetical protein Mfla_1981 15 None None None 91776655 Common - cytochrome B561 Mfla_2303 82 COG3038 CybB, Cytochrome B561 Energy production and conversion 91774381 Common - acetyl-CoA carboxylase, biotin carboxyl carrier protein Mfla_0025 194 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 91776131 Nonpathogen - hypothetical protein Mfla_1778 6 None None None 91774829 Common - conserved hypothetical protein 701 Mfla_0474 97 COG1981 COG1981, Predicted membrane protein Function unknown 91775864 Common - acetyl-CoA carboxylase Mfla_1511 236 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 91774979 Common - glutamate racemase Mfla_0624 193 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 91775377 Common - hypothetical protein Mfla_1024 25 None None None 91774518 Common - alpha/beta hydrolase fold Mfla_0162 39 COG2267 PldB, Lysophospholipase Lipid metabolism 91775233 Common - hypothetical protein Mfla_0880 25 None None None 91775716 Common - protein of unknown function DUF204 Mfla_1363 63 COG1971 COG1971, Predicted membrane protein Function unknown 91774557 Common - transmembrane proetin, twin-arginine translocation pathway signal Mfla_0201 21 COG5501 COG5501, Predicted secreted protein Function unknown 91775370 Common - heat shock protein 90 Mfla_1017 150 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 91776939 Common - CheB methylesterase Mfla_2589 151 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 91775226 Common - heat shock protein 90 Mfla_0873 150 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 91774770 Common - LemA Mfla_0415 132 COG1704 LemA, Uncharacterized conserved protein Function unknown 91777036 Common - hypothetical protein Mfla_2688 4 None None None 91776413 Common - NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 Mfla_2061 163 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 91775063 Nonpathogen - hypothetical protein Mfla_0710 1 None None None 91775720 Common - glycogen branching enzyme Mfla_1367 156 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 91776189 Common - ATPase associated with various cellular activities, AAA_3 Mfla_1837 173 COG0714 COG0714, MoxR-like ATPases General function prediction only 91776419 Common - phosphohistidine phosphatase, SixA Mfla_2067 51 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 91776082 Common - HAD-superfamily hydrolase subfamily IA, variant 3 Mfla_1729 190 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 91776629 Common - methyltransferase Mfla_2277 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 91774572 Common - hypothetical protein Mfla_0216 12 None None None 91774899 Common - Sec-independent protein translocase TatC Mfla_0544 198 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 91775344 Nonpathogen - hypothetical protein Mfla_0991 5 None None None 91774649 Common - ribosomal protein S8 Mfla_0293 242 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 91776097 Common - hypothetical protein Mfla_1744 57 COG3164 COG3164, Predicted membrane protein Function unknown 91774423 Common - translation initiation factor IF-2 Mfla_0067 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 91775658 Common - Secretion protein HlyD Mfla_1305 160 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 91775782 Common - copper resistance protein CopC Mfla_1429 25 COG2372 CopC, Uncharacterized protein, homolog of Cu resistance protein CopC General function prediction only 91776381 Nonpathogen - hypothetical protein Mfla_2029 10 None None None 91774438 Nonpathogen - hypothetical protein Mfla_0082 3 None None None 91775535 Common - filamentation induced by cAMP protein Fic Mfla_1182 97 COG3177 COG3177, Uncharacterized conserved protein Function unknown 91776638 Common - hypothetical protein Mfla_2286 19 None None None 91774967 Common - diguanylate phosphodiesterase (EAL domain) Mfla_0612 156 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 91776843 Common - Rod shape-determining protein MreD Mfla_2493 52 COG2891 MreD, Cell shape-determining protein Cell envelope biogenesis, outer membrane 91775641 Common rpmJ 50S ribosomal protein L36 Mfla_1288 61 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 91775646 Common - cytochrome c oxidase, subunit III Mfla_1293 158 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 91776221 Common - succinyl-diaminopimelate desuccinylase Mfla_1869 209 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 91776355 Common - threonyl-tRNA synthetase Mfla_2003 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 91774795 Common - hypothetical protein Mfla_0440 12 None None None 91775251 Common - protein of unknown function DUF455 Mfla_0898 46 COG2833 COG2833, Uncharacterized protein conserved in bacteria Function unknown 91774490 Common - TonB-dependent receptor Mfla_0134 116 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 91774393 Common - histidine kinase internal region Mfla_0037 102 COG2972 COG2972, Predicted signal transduction protein with a C-terminal ATPase domain Signal transduction mechanisms 91774778 Common - S-adenosylmethionine Mfla_0423 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 91775596 Common - response regulator receiver domain protein (CheY-like) Mfla_1243 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 91774956 Common - metal dependent phosphohydrolase Mfla_0601 72 COG1203 COG1203, Predicted helicases General function prediction only 91775893 Common - ABC transporter related Mfla_1540 249 COG4172 COG4172, ABC-type uncharacterized transport system, duplicated ATPase component General function prediction only 91776370 Nonpathogen - O-antigen polymerase Mfla_2018 1 None None None 91774600 Common - BolA-like protein Mfla_0244 112 COG5007 COG5007, Predicted transcriptional regulator, BolA superfamily Transcription 91775509 Common - hypothetical protein Mfla_1156 20 None None None 91774994 Common - globin Mfla_0639 112 COG1017 Hmp, Hemoglobin-like flavoprotein Energy production and conversion 91775640 Common - predicted kinase Mfla_1287 54 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 91777098 Common - F0F1 ATP synthase subunit A Mfla_2750 191 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 91776949 Common - 6-phosphogluconate dehydrogenase Mfla_2599 158 COG0362 Gnd, 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 91777084 Common - putative FecR Mfla_2736 45 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 91774656 Common infA translation initiation factor IF-1 Mfla_0300 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 91775125 Common - Ferrochelatase Mfla_0772 160 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 91775193 Nonpathogen - Lip Mfla_0840 1 None None None 91775051 Common - ubiquinone/menaquinone biosynthesis methyltransferases Mfla_0698 219 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 91777068 Common - hypothetical protein Mfla_2720 7 None None None 91774865 Common - protein of unknown function DUF21 Mfla_0510 219 COG4536 CorB, Putative Mg2+ and Co2+ transporter CorB Inorganic ion transport and metabolism 91775503 Nonpathogen - hypothetical protein Mfla_1150 1 None None None 91776103 Common - hypothetical protein Mfla_1750 10 None None None 91775415 Common - 6-phosphogluconate dehydrogenase-like protein Mfla_1062 185 COG1023 Gnd, Predicted 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 91775671 Nonpathogen - hypothetical protein Mfla_1318 1 None None None 91775058 Common - ABC transporter related Mfla_0705 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 91774940 Common - VacJ-like lipoprotein Mfla_0585 94 COG2853 VacJ, Surface lipoprotein Cell envelope biogenesis, outer membrane 91775514 Common - thioredoxin Mfla_1161 232 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 91776711 Common - transcriptional regulator, MarR family Mfla_2359 92 COG1846 MarR, Transcriptional regulators Transcription 91776982 Common - Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B Mfla_2634 86 COG3384 COG3384, Uncharacterized conserved protein Function unknown 91774749 Common - transglutaminase-like protein Mfla_0393 91 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 91774453 Common - Sel1 Mfla_0097 97 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 91776412 Common - NADH-quinone oxidoreductase, B subunit Mfla_2060 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 91774488 Common - polyphosphate kinase Mfla_0132 161 COG0855 Ppk, Polyphosphate kinase Inorganic ion transport and metabolism 91774561 Common - phosphoribosylformylglycinamidine cyclo-ligase Mfla_0205 232 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 91775796 Nonpathogen - hypothetical protein Mfla_1443 1 None None None 91775263 Nonpathogen - hypothetical protein Mfla_0910 3 None None None 91776811 Common - type IV pilus assembly protein PilM Mfla_2461 77 COG4972 PilM, Tfp pilus assembly protein, ATPase PilM Cell motility and secretion / Intracellular trafficking and secretion 91774482 Common - protein of unknown function DUF589 Mfla_0126 93 COG2947 COG2947, Uncharacterized conserved protein Function unknown 91775303 Nonpathogen - transport-associated Mfla_0950 6 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 91776791 Common - Chromate transporter Mfla_2441 103 COG2059 ChrA, Chromate transport protein ChrA Inorganic ion transport and metabolism 91776253 Nonpathogen - hypothetical protein Mfla_1901 2 None None None 91774643 Common - ribosomal protein L29 Mfla_0287 40 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 91776255 Nonpathogen - hypothetical protein Mfla_1903 2 None None None 91775835 Common - Lytic transglycosylase, catalytic Mfla_1482 150 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 91774742 Common - Superoxide dismutase Mfla_0386 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 91776226 Common - chromosome segregation and condensation protein ScpA Mfla_1874 143 COG1354 COG1354, Uncharacterized conserved protein Function unknown 91776728 Common - hypothetical protein Mfla_2378 29 None None None 91774651 Common rplR 50S ribosomal protein L18 Mfla_0295 216 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 91776467 Common - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Mfla_2115 219 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 91775836 Common - extracellular solute-binding protein, family 5 Mfla_1483 214 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 91777028 Common - putative FecR Mfla_2680 45 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 91774612 Common - phosphoribosyl-ATP pyrophosphohydrolase Mfla_0256 153 COG0140 HisI, Phosphoribosyl-ATP pyrophosphohydrolase Amino acid transport and metabolism 91774664 Nonpathogen - hypothetical protein Mfla_0308 2 None None None 91776517 Nonpathogen - hypothetical protein Mfla_2165 2 None None None 91774503 Common - HPrNtr Mfla_0147 152 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 91776171 Common - adenylosuccinate lyase Mfla_1819 235 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 91775861 Common - fatty acid/phospholipid synthesis protein Mfla_1508 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 91775085 Common - ABC transporter related Mfla_0732 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 91775559 Common - Alkaline phosphatase Mfla_1206 86 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 91775947 Common - transcriptional regulator, TetR family Mfla_1594 100 COG1309 AcrR, Transcriptional regulator Transcription 91775502 Common - transcriptional regulator, LysR family Mfla_1149 114 COG0583 LysR, Transcriptional regulator Transcription 91776800 Common - nitrogen metabolism transcriptional regulator, NtrC, Fis Family Mfla_2450 221 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 91776289 Common - response regulator receiver domain protein (CheY-like) Mfla_1937 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 91775601 Common - acetyl-CoA carboxylase, carboxyl transferase, alpha subunit Mfla_1248 200 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 91774540 Common - sun protein Mfla_0184 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 91774446 Common - hypothetical protein Mfla_0090 6 None None None 91776667 Common - proline iminopeptidase Mfla_2315 135 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 91774539 Common - putative proline rich signal peptide protein Mfla_0183 26 None None None 91776682 Common - methylated-DNA--protein-cysteine methyltransferase Mfla_2330 208 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 91774388 Common - HemY-like protein Mfla_0032 50 COG3071 HemY, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 91774763 Common - Leucine-rich repeat, typical subtype Mfla_0408 22 COG4886 COG4886, Leucine-rich repeat (LRR) protein Function unknown 91775618 Common - RNA-binding S4 Mfla_1265 98 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 91776495 Common - putative thiol:disulphide interchange protein Mfla_2143 68 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 91775576 Common - ribonucleotide-diphosphate reductase subunit alpha Mfla_1223 204 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 91776721 Common - putative lipoprotein Mfla_2369 16 COG3218 COG3218, ABC-type uncharacterized transport system, auxiliary component General function prediction only 91777100 Common - parB-like partition proteins Mfla_2752 186 COG1475 Spo0J, Predicted transcriptional regulators Transcription 91777033 Common - Phage-related protein tail component-like protein Mfla_2685 21 COG4733 COG4733, Phage-related protein, tail component Function unknown 91775728 Common - hypothetical protein Mfla_1375 25 COG3394 COG3394, Uncharacterized protein conserved in bacteria Function unknown 91776427 Common - catalytic domain of components of various dehydrogenase complexes Mfla_2075 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 91774532 Nonpathogen - hypothetical protein Mfla_0176 1 None None None 91775550 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Mfla_1197 221 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 91776122 Common ureA urease subunit gamma Mfla_1769 96 COG0831 UreA, Urea amidohydrolase (urease) gamma subunit Amino acid transport and metabolism 91776039 Common - chorismate mutase Mfla_1686 212 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 91775744 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Mfla_1391 146 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 91776041 Common - DNA gyrase subunit A Mfla_1688 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 91776754 Common - MotA/TolQ/ExbB proton channel Mfla_2404 49 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 91775314 Common - Dihydroxyacetone kinase, subunit L Mfla_0961 76 COG2376 DAK1, Dihydroxyacetone kinase Carbohydrate transport and metabolism 91776151 Common - major facilitator superfamily MFS_1 Mfla_1799 15 COG3202 COG3202, ATP/ADP translocase Energy production and conversion 91776096 Common - ABC transporter related Mfla_1743 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 91776282 Common - chemotaxis-specific methylesterase Mfla_1930 219 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 91776951 Common - PsiF Mfla_2601 23 None None None 91776178 Common - peptidase M23B Mfla_1826 187 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 91776502 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Mfla_2150 164 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 91774397 Common - hypothetical protein Mfla_0041 8 None None None 91776323 Common fliM flagellar motor switch protein FliM Mfla_1971 114 COG1868 FliM, Flagellar motor switch protein Cell motility and secretion 91776499 Common - Nucleotidyl transferase Mfla_2147 208 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 91776346 Common - protein of unknown function DUF779 Mfla_1994 42 COG3564 COG3564, Uncharacterized protein conserved in bacteria Function unknown 91776798 Common - hypothetical protein Mfla_2448 3 None None None 91775400 Common - aminotransferase AlaT Mfla_1047 239 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 91774909 Common - MauM/NapG family ferredoxin-type protein Mfla_0554 62 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 91776875 Common - A/G-specific adenine glycosylase Mfla_2525 227 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 91776881 Common - protein-L-isoaspartate(D-aspartate) O-methyltransferase Mfla_2531 160 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 91774581 Common - glycine cleavage system H protein Mfla_0225 185 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 91776816 Common - hypothetical protein Mfla_2466 12 None None None 91774441 Common - UBA/THIF-type NAD/FAD binding fold Mfla_0085 223 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 91776874 Common - conserved hypothetical protein-putative formaldehyde-activating enzyme Mfla_2524 27 COG1795 COG1795, Uncharacterized conserved protein Function unknown 91775002 Common - large conductance mechanosensitive channel protein Mfla_0647 117 COG1970 MscL, Large-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 91774792 Common - transcriptional regulator, XRE family with cupin sensor domain Mfla_0437 125 COG1396 HipB, Predicted transcriptional regulators Transcription 91775182 Nonpathogen - hypothetical protein Mfla_0829 1 None None None 91776077 Nonpathogen - hypothetical protein Mfla_1724 1 None None None 91774549 Common - S-adenosyl-L-homocysteine hydrolase Mfla_0193 177 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 91774357 Common - chromosomal replication initiator protein DnaA Mfla_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 91775779 Common - short-chain dehydrogenase/reductase SDR Mfla_1426 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 91774468 Nonpathogen - hypothetical protein Mfla_0112 1 None None None 91775735 Common - beta-lactamase-like protein Mfla_1382 131 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 91775826 Common - oligoribonuclease Mfla_1473 88 COG1949 Orn, Oligoribonuclease (3'->5' exoribonuclease) RNA processing and modification 91776396 Common - Pyrrolo-quinoline quinone Mfla_2044 59 COG4993 Gcd, Glucose dehydrogenase Carbohydrate transport and metabolism 91774634 Common rpsJ 30S ribosomal protein S10 Mfla_0278 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 91776560 Common - isoleucyl-tRNA synthetase Mfla_2208 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 91774968 Nonpathogen - hypothetical protein Mfla_0613 1 None None None 91774599 Common - ABC-2 Mfla_0243 147 COG1511 COG1511, Predicted membrane protein Function unknown 91776546 Nonpathogen - protein of unknown function DUF1555 Mfla_2194 1 None None None 91774826 Common - PfkB Mfla_0471 161 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 91776076 Common - L-sorbosone dehydrogenase Mfla_1723 65 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 91776540 Common - phosphoglyceromutase Mfla_2188 125 COG0696 GpmI, Phosphoglyceromutase Carbohydrate transport and metabolism 91775080 Common - electron transfer flavoprotein beta-subunit Mfla_0727 152 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 91774750 Common - hypothetical protein Mfla_0394 2 None None None 91774408 Common - ATP-dependent DNA helicase RecG Mfla_0052 223 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 91776208 Common - Glutamate--ammonia ligase Mfla_1856 220 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 91776907 Common - secretion protein HlyD Mfla_2557 145 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 91775706 Common - sigma-24 (FecI-like) Mfla_1353 59 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 91775485 Nonpathogen - protein of unknown function DUF1555 Mfla_1132 1 None None None 91775280 Common rpsA 30S ribosomal protein S1 Mfla_0927 220 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 91774758 Common - transcriptional regulator, LysR family Mfla_0402 123 COG0583 LysR, Transcriptional regulator Transcription 91775584 Common - cobalamin synthesis protein, P47K Mfla_1231 128 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 91775886 Common - protein of unknown function DUF861, cupin_3 Mfla_1533 25 COG3450 COG3450, Predicted enzyme of the cupin superfamily General function prediction only 91774931 Common - putative site-specific recombinase, prophage insertion Mfla_0576 23 COG4389 COG4389, Site-specific recombinase DNA replication, recombination, and repair 91774814 Common - ferredoxin-dependent glutamate synthase Mfla_0459 195 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 91775290 Common - Heavy metal transport/detoxification protein Mfla_0937 31 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 91776970 Common - transcriptional regulator, LysR family Mfla_2621 168 COG0583 LysR, Transcriptional regulator Transcription 91775717 Common - lipopolysaccharide kinase Mfla_1364 8 None None None 91775757 Common - 3'(2'),5'-bisphosphate nucleotidase Mfla_1404 185 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 91776244 Common - transcriptional regulator, GntR family Mfla_1892 222 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 91775843 Common - putative signal transduction protein with CBS domains Mfla_1490 73 COG0517 COG0517, FOG: CBS domain General function prediction only 91776654 Nonpathogen - hypothetical protein Mfla_2302 1 None None None 91776400 Common - Proton-translocating NADH-quinone oxidoreductase, chain N Mfla_2048 209 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 91777070 Nonpathogen - hypothetical protein Mfla_2722 1 None None None 91774925 Common recA recombinase A Mfla_0570 215 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 91775825 Common - Glycogen/starch synthases, ADP-glucose type Mfla_1472 157 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 91774952 Common - 3-methyl-2-oxobutanoate hydroxymethyltransferase Mfla_0597 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 91776387 Common - MxaL protein, putative Mfla_2035 9 None None None 91775958 Common - periplasmic binding protein Mfla_1605 111 COG4558 ChuT, ABC-type hemin transport system, periplasmic component Inorganic ion transport and metabolism 91776307 Common - flagellar basal-body rod protein FlgC Mfla_1955 126 COG1558 FlgC, Flagellar basal body rod protein Cell motility and secretion 91774900 Common - transcriptional regulator, AraC family Mfla_0545 60 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 91777018 Nonpathogen - hypothetical protein Mfla_2670 1 None None None 91776608 Common - Pyrimidine 5-nucleotidase Mfla_2256 47 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 91775590 Common - hypothetical protein Mfla_1237 39 COG1694 MazG, Predicted pyrophosphatase General function prediction only 91776004 Common - histidine biosynthesis Mfla_1651 34 COG1411 COG1411, Uncharacterized protein related to proFAR isomerase (HisA) General function prediction only 91776280 Common - Chemotaxis phosphatase, CheZ Mfla_1928 44 COG3143 CheZ, Chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 91775513 Common - hypothetical protein Mfla_1160 19 None None None 91776217 Common - peptidase M48, Ste24p Mfla_1865 122 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 91774394 Common - argininosuccinate lyase Mfla_0038 240 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 91776997 Nonpathogen - hypothetical protein Mfla_2649 1 None None None 91775083 Nonpathogen - hypothetical protein Mfla_0730 4 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 91775298 Common - two component transcriptional regulator, LuxR family Mfla_0945 224 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 91776533 Common - hypothetical protein Mfla_2181 171 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 91774836 Common - hypothetical protein Mfla_0481 2 None None None 91775807 Nonpathogen - hypothetical protein Mfla_1454 3 None None None 91776294 Common - transcriptional activator FlhC Mfla_1942 27 None None None 91775269 Common dcd deoxycytidine triphosphate deaminase Mfla_0916 149 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 91775520 Common - hypothetical protein Mfla_1167 6 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 91776748 Nonpathogen - hypothetical protein Mfla_2398 1 None None None 91776315 Common flgK flagellar hook-associated protein FlgK Mfla_1963 124 COG1256 FlgK, Flagellar hook-associated protein Cell motility and secretion 91776669 Common - putative hydroxylase Mfla_2317 44 COG3128 PiuC, Uncharacterized iron-regulated protein Function unknown 91777106 Common - 60 kDa inner membrane insertion protein Mfla_2758 214 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 91776454 Common pyrB aspartate carbamoyltransferase catalytic subunit Mfla_2102 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 91775184 Common - bacteriophage replication gene A Mfla_0831 18 None None None 91775039 Common - formamidopyrimidine-DNA glycosylase Mfla_0686 181 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 91774513 Nonpathogen - hypothetical protein Mfla_0157 8 None None None 91776743 Common - protein of unknown function DUF11 Mfla_2393 89 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 91775009 Common - two component transcriptional regulator, winged helix family Mfla_0654 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 91776461 Common - pyrroline-5-carboxylate reductase Mfla_2109 215 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 91776895 Common - RND multidrug efflux transporter MexB Mfla_2545 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 91775333 Common - fkbp-type peptidyl-prolyl cis-trans isomerase Mfla_0980 128 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 91775967 Common - Small GTP-binding protein domain Mfla_1614 237 COG1160 COG1160, Predicted GTPases General function prediction only 91776595 Common - fructose-1,6-bisphosphate aldolase Mfla_2243 175 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 91774872 Common - 2-isopropylmalate synthase Mfla_0517 211 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 91774690 Common - carbon starvation protein CstA Mfla_0334 109 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 91775908 Common - ABC transporter related Mfla_1555 248 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 91774730 Common - secretion protein HlyD Mfla_0374 143 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 91776736 Common - hypothetical protein Mfla_2386 57 COG2331 COG2331, Uncharacterized protein conserved in bacteria Function unknown 91774385 Common - CutA1 divalent ion tolerance protein Mfla_0029 120 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 91776165 Common - protein of unknown function DUF442 Mfla_1813 97 COG3453 COG3453, Uncharacterized protein conserved in bacteria Function unknown 91775467 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) Mfla_1114 193 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 91774591 Nonpathogen - ATP-binding region, ATPase-like protein Mfla_0235 5 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 91775013 Common - Potassium efflux system protein Mfla_0658 217 COG4651 RosB, Kef-type K+ transport system, predicted NAD-binding component Inorganic ion transport and metabolism 91776983 Common - MltA Mfla_2635 93 COG2821 MltA, Membrane-bound lytic murein transglycosylase Cell envelope biogenesis, outer membrane 91775764 Common - ATP-dependent protease La Mfla_1411 213 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 91775690 Common - hypothetical protein Mfla_1337 7 None None None 91775624 Common - GDP-mannose 4,6-dehydratase Mfla_1271 224 COG1089 Gmd, GDP-D-mannose dehydratase Cell envelope biogenesis, outer membrane 91775708 Common - YceI Mfla_1355 13 COG2353 COG2353, Uncharacterized conserved protein Function unknown 91775855 Common - aminotransferase, class IV Mfla_1502 167 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 91776940 Common - response regulator receiver sensor signal transduction histidine kinase Mfla_2590 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 91776574 Common - secretion protein HlyD Mfla_2222 144 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 91774843 Common - multi-sensor signal transduction histidine kinase Mfla_0488 222 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 91776826 Common - modification methylase, HemK family Mfla_2476 211 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 91774401 Common - serine/threonine protein kinase Mfla_0045 145 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 91776428 Common - Dihydrolipoamide dehydrogenase Mfla_2076 241 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 91775567 Common - oxidoreductase-like protein Mfla_1214 167 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 91775046 Common - transcriptional regulator, MerR family Mfla_0693 120 COG0789 SoxR, Predicted transcriptional regulators Transcription 91776262 Common - 2-dehydro-3-deoxyphosphooctonate aldolase Mfla_1910 186 COG2877 KdsA, 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase Cell envelope biogenesis, outer membrane 91775790 Common - integral membrane protein Mfla_1437 25 COG5528 COG5528, Predicted integral membrane protein Function unknown 91776830 Common metX homoserine O-acetyltransferase Mfla_2480 134 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 91774390 Common - Uroporphyrinogen-III synthase Mfla_0034 132 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 91776869 Nonpathogen - hypothetical protein Mfla_2519 4 COG4726 PilX, Tfp pilus assembly protein PilX Cell motility and secretion / Intracellular trafficking and secretion 91776010 Common - S6 modification enzyme RimK Mfla_1657 90 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 91775131 Common - carbamoyl-phosphate synthase, small subunit Mfla_0778 235 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 91774413 Common argC N-acetyl-gamma-glutamyl-phosphate reductase Mfla_0057 214 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 91774938 Common - protein of unknown function DUF615 Mfla_0583 61 COG3028 COG3028, Uncharacterized protein conserved in bacteria Function unknown 91776707 Common - hypothetical protein Mfla_2355 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 91775107 Common - glycosyl transferase, group 1 Mfla_0754 95 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 91776015 Common - formylmethanofuran dehydrogenase Mfla_1662 23 COG1029 FwdB, Formylmethanofuran dehydrogenase subunit B Energy production and conversion 91776868 Common - Tfp pilus assembly protein tip-associated adhesin PilY1-like protein Mfla_2518 40 COG3419 PilY1, Tfp pilus assembly protein, tip-associated adhesin PilY1 Cell motility and secretion / Intracellular trafficking and secretion 91776017 Common - tetrahydromethanopterin formyltransferase Mfla_1664 24 COG2037 Ftr, Formylmethanofuran:tetrahydromethanopterin formyltransferase Energy production and conversion 91775091 Common - 4Fe-4S ferredoxin, iron-sulfur binding Mfla_0738 109 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 91777019 Nonpathogen - hypothetical protein Mfla_2671 1 None None None 91775732 Common - 4Fe-4S cluster binding Mfla_1379 135 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 91775926 Common - conserved hypothetical protein 103 Mfla_1573 189 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 91775929 Common - ubiquinone biosynthesis O-methyltransferase Mfla_1576 196 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 91777027 Common - TonB-dependent receptor Mfla_2679 40 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 91775771 Common - Trehalose synthase-like protein Mfla_1418 166 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 91777020 Common - primosomal protein N' Mfla_2672 212 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 91774808 Common - Sarcosine oxidase, delta subunit, heterotetrameric Mfla_0453 28 COG4311 SoxD, Sarcosine oxidase delta subunit Amino acid transport and metabolism 91776331 Common fliE flagellar hook-basal body protein FliE Mfla_1979 93 COG1677 FliE, Flagellar hook-basal body protein Cell motility and secretion / Intracellular trafficking and secretion 91777059 Common - hypothetical protein Mfla_2711 9 None None None 91775692 Common - hypothetical protein Mfla_1339 6 None None None 91776321 Nonpathogen - flagellar biosynthesis protein, FliO Mfla_1969 1 COG3190 FliO, Flagellar biogenesis protein Cell motility and secretion 91776520 Common - beta-lactamase-like protein Mfla_2168 182 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 91775353 Common - RNA polymerase sigma factor RpoE Mfla_1000 174 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 91775951 Nonpathogen - protein of unknown function DUF1555 Mfla_1598 1 None None None 91776264 Common - YjeF-related protein-like protein Mfla_1912 219 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 91776837 Common - hypothetical protein Mfla_2487 6 None None None 91774678 Common - uroporphyrin-III C-methyltransferase Mfla_0322 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 91776486 Common - protein of unknown function DUF198 Mfla_2134 79 COG1469 COG1469, Uncharacterized conserved protein Function unknown 91775154 Common - phosphate-selective porin O and P Mfla_0801 11 COG3746 OprP, Phosphate-selective porin Inorganic ion transport and metabolism 91776927 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Mfla_2577 91 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 91775397 Common - metallophosphoesterase Mfla_1044 9 COG1409 Icc, Predicted phosphohydrolases General function prediction only 91775977 Common - Nucleoside-diphosphate kinase Mfla_1624 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 91775392 Common - PAAR Mfla_1039 29 COG4104 COG4104, Uncharacterized conserved protein Function unknown 91774853 Common - ErfK/YbiS/YcfS/YnhG Mfla_0498 26 COG3034 COG3034, Uncharacterized protein conserved in bacteria Function unknown 91774375 Common - CBS domain containing membrane protein Mfla_0019 145 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 91775460 Common - tRNA/rRNA methyltransferase (SpoU) Mfla_1107 208 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 91775862 Common rpmF 50S ribosomal protein L32 Mfla_1509 91 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 91774713 Common - molybdopterin binding domain Mfla_0357 163 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 91774886 Common - two component transcriptional regulator, LuxR family Mfla_0531 158 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 91776059 Common - nucleotide-binding protein Mfla_1706 107 COG1666 COG1666, Uncharacterized protein conserved in bacteria Function unknown 91774910 Common - Ferredoxin-type protein, NapH/MauN family Mfla_0555 82 COG0348 NapH, Polyferredoxin Energy production and conversion 91776928 Common - hypothetical protein Mfla_2578 22 COG2863 COG2863, Cytochrome c553 Energy production and conversion 91775025 Nonpathogen - hypothetical protein Mfla_0672 1 None None None 91775931 Common - OmpA/MotB Mfla_1578 151 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 91774801 Common - amino acid permease-associated region Mfla_0446 64 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 91774726 Common - transcriptional regulator, ArsR family Mfla_0370 32 COG0640 ArsR, Predicted transcriptional regulators Transcription 91775126 Common hrcA heat-inducible transcription repressor Mfla_0773 151 COG1420 HrcA, Transcriptional regulator of heat shock gene Transcription 91776338 Common - flagellin-like protein Mfla_1986 115 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 91775998 Common - peptidase A24A, prepilin type IV Mfla_1645 5 COG4960 CpaA, Flp pilus assembly protein, protease CpaA Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 91775476 Nonpathogen - hypothetical protein Mfla_1123 1 None None None 91775780 Common - hypothetical protein Mfla_1427 13 None None None 91775917 Common - sulfonate ABC transporter, periplasmic sulfonate-binding protein SsuA Mfla_1564 66 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 91775878 Common - phosphatidate cytidylyltransferase Mfla_1525 215 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 91776099 Common - peptidase U62, modulator of DNA gyrase Mfla_1746 170 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 91774537 Common - two component, sigma54 specific, transcriptional regulator, Fis family Mfla_0181 223 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 91774965 Common - Sulfate ABC transporter, permease protein CysW Mfla_0610 227 COG4208 CysW, ABC-type sulfate transport system, permease component Inorganic ion transport and metabolism 91775871 Common - acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase Mfla_1518 160 COG1043 LpxA, Acyl- acyl carrier protein 91776429 Common - hypothetical protein Mfla_2077 6 None None None 91775197 Nonpathogen - hypothetical protein Mfla_0844 4 None None None 91774850 Common - UDP-2,3-diacylglucosamine hydrolase Mfla_0495 78 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 91776641 Common - thioredoxin Mfla_2289 232 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 91776366 Common - glycoside hydrolase, family 5 Mfla_2014 24 COG2730 BglC, Endoglucanase Carbohydrate transport and metabolism 91775316 Common - tRNA/rRNA methyltransferase (SpoU) Mfla_0963 9 None None None 91775831 Common - DNA polymerase III, epsilon subunit Mfla_1478 191 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 91777048 Common - hypothetical protein Mfla_2700 3 None None None 91776518 Common - putative lipoprotein Mfla_2166 15 None None None 91776504 Common - dimethyladenosine transferase Mfla_2152 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 91774558 Common - hypothetical protein Mfla_0202 16 None None None 91776214 Common - Disulphide bond formation protein DsbB Mfla_1862 50 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 91774654 Common - ribosomal protein L15 Mfla_0298 206 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 91776378 Common - polysaccharide export protein Mfla_2026 97 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 91776793 Common - diaminopimelate decarboxylase Mfla_2443 217 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 91775818 Nonpathogen - hypothetical protein Mfla_1465 1 None None None 91776584 Common argJ bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein Mfla_2232 167 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 91776090 Common prfC peptide chain release factor 3 Mfla_1737 249 COG4108 PrfC, Peptide chain release factor RF-3 Translation, ribosomal structure and biogenesis 91774579 Common - DNA polymerase III chi subunit, HolC Mfla_0223 31 COG2927 HolC, DNA polymerase III, chi subunit DNA replication, recombination, and repair 91775217 Common - GTP-binding protein Era Mfla_0864 231 COG1159 Era, GTPase General function prediction only 91774999 Common - Glycine--tRNA ligase Mfla_0644 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 91776500 Common - aminoglycoside phosphotransferase Mfla_2148 91 COG3178 COG3178, Predicted phosphotransferase related to Ser/Thr protein kinases General function prediction only 91775747 Common - Methyltransferase type 12 Mfla_1394 68 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 91774990 Common - Heavy metal translocating P-type ATPase Mfla_0635 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 91776991 Common - short-chain dehydrogenase/reductase SDR Mfla_2643 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 91775519 Common - heat shock protein Hsp20 Mfla_1166 121 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 91776446 Common - Lipoprotein releasing system, ATP-binding protein Mfla_2094 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 91777089 Common - D-fructose-6-phosphate amidotransferase Mfla_2741 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 91776157 Common - 4-oxalocrotonate tautomerase Mfla_1805 12 COG1942 COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog General function prediction only 91776066 Nonpathogen - hypothetical protein Mfla_1713 1 None None None 91774724 Common - transcriptional regulator, TetR family Mfla_0368 84 COG1309 AcrR, Transcriptional regulator Transcription 91775492 Common guaA bifunctional GMP synthase/glutamine amidotransferase protein Mfla_1139 239 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 91775579 Common - protein of unknown function UPF0118 Mfla_1226 200 COG0628 PerM, Predicted permease General function prediction only 91775417 Common - protein of unknown function DUF59 Mfla_1064 234 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 91775634 Common - response regulator receiver domain protein (CheY-like) Mfla_1281 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 91775429 Common aat leucyl/phenylalanyl-tRNA--protein transferase Mfla_1076 134 COG2360 Aat, Leu/Phe-tRNA-protein transferase Posttranslational modification, protein turnover, chaperones 91776410 Common - NADH dehydrogenase subunit D Mfla_2058 191 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 91775401 Common - homoserine dehydrogenase Mfla_1048 217 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 91776893 Common - formaldehyde-activating enzyme Mfla_2543 25 COG1795 COG1795, Uncharacterized conserved protein Function unknown 91775898 Common - hypothetical protein Mfla_1545 6 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 91775325 Common - hypothetical protein Mfla_0972 5 None None None 91775437 Common - hypothetical protein Mfla_1084 4 COG3735 COG3735, Uncharacterized protein conserved in bacteria Function unknown 91776731 Common - quinolinate synthetase Mfla_2381 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 91776219 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Mfla_1867 170 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 91774502 Common - PTS system fructose subfamily IIA component Mfla_0146 95 COG2893 ManX, Phosphotransferase system, mannose/fructose-specific component IIA Carbohydrate transport and metabolism 91775260 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Mfla_0907 172 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 91776129 Common - Glutamine amidotransferase, class-II Mfla_1776 24 COG2331 COG2331, Uncharacterized protein conserved in bacteria Function unknown 91777045 Nonpathogen - hypothetical protein Mfla_2697 1 None None None 91777055 Common - N-acetylmuramoyl-L-alanine amidase, family 2 Mfla_2707 12 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 91774877 Common - signal recognition particle protein Mfla_0522 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 91777091 Common - ATP synthase F1, epsilon subunit Mfla_2743 177 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 91774608 Common - imidazole glycerol phosphate synthase, glutamine amidotransferase subunit Mfla_0252 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 91776824 Common prfA peptide chain release factor 1 Mfla_2474 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 91776181 Common - nitroreductase Mfla_1829 91 COG0778 NfnB, Nitroreductase Energy production and conversion 91775798 Common - hypothetical protein Mfla_1445 23 COG3336 COG3336, Predicted membrane protein Function unknown 91775838 Common - binding-protein-dependent transport systems inner membrane component Mfla_1485 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 91774880 Common - phospho-2-dehydro-3-heoxyheptonate aldolase Mfla_0525 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 91776343 Common - protein of unknown function DUF1111 Mfla_1991 52 COG3488 COG3488, Predicted thiol oxidoreductase Energy production and conversion 91776329 Common - flagellar motor switch protein FliG Mfla_1977 124 COG1536 FliG, Flagellar motor switch protein Cell motility and secretion 91774477 Common - hypothetical protein Mfla_0121 6 None None None 91776145 Common - Hydrophobe/amphiphile efflux-1 HAE1 Mfla_1793 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 91776407 Common - NADH dehydrogenase subunit G Mfla_2055 199 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 91774906 Common - Amine dehydrogenase Mfla_0551 12 None None None 91774387 Common - CDP-6-deoxy-delta-3,4-glucoseen reductase Mfla_0031 163 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 91775914 Common - ABC transporter related Mfla_1561 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 91776490 Common - Pseudouridine synthase, Rsu Mfla_2138 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 91775231 Common - Biopolymer transport protein ExbD/TolR Mfla_0878 130 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 91775136 Common - ATP-dependent metalloprotease FtsH Mfla_0783 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 91774485 Common - ribose-5-phosphate isomerase A Mfla_0129 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 91776710 Nonpathogen - conserved hypothetical signal peptide protein Mfla_2358 3 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 91774748 Common - protein of unknown function DUF403 Mfla_0392 82 COG2307 COG2307, Uncharacterized protein conserved in bacteria Function unknown 91774436 Nonpathogen - hypothetical protein Mfla_0080 6 None None None 91777012 Common - glutamate-1-semialdehyde-2,1-aminomutase Mfla_2664 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 91775648 Common - ubiquinol oxidase, subunit II Mfla_1295 148 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 91774420 Common - tyrosyl-tRNA synthetase Mfla_0064 242 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 91776456 Common - Twin-arginine translocation pathway signal Mfla_2104 66 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 91776101 Common - transcription-repair coupling factor Mfla_1748 234 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 91775664 Nonpathogen - hypothetical protein Mfla_1311 1 None None None 91774958 Common - CRISPR-associated protein, CT1133 Mfla_0603 29 None None None 91777108 Common rnpA ribonuclease P Mfla_2760 76 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 91776946 Common - proline-rich region Mfla_2596 10 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 91775652 Common - DNA-3-methyladenine glycosylase II Mfla_1299 103 COG0122 AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 91776636 Common - phosphoheptose isomerase Mfla_2284 123 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 91775253 Common - metallophosphoesterase Mfla_0900 9 COG1409 Icc, Predicted phosphohydrolases General function prediction only 91774893 Common - hypothetical protein Mfla_0538 4 None None None 91776271 Common - NADH:flavin oxidoreductase/NADH oxidase Mfla_1919 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 91775582 Common - cobalamin synthesis protein, P47K Mfla_1229 126 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 91775120 Nonpathogen - hypothetical protein Mfla_0767 2 None None None 91775434 Common - Heavy metal transport/detoxification protein Mfla_1081 31 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 91776030 Common - Drug resistance transporter Bcr/CflA subfamily Mfla_1677 205 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 91775071 Common - putative NAD-dependent formate dehydrogenase delta subunit Mfla_0718 18 None None None 91774492 Common - FAD dependent oxidoreductase Mfla_0136 155 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 91775538 Common - thioredoxin-related Mfla_1185 231 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 91776377 Common - lipopolysaccharide biosynthesis Mfla_2025 96 COG3206 GumC, Uncharacterized protein involved in exopolysaccharide biosynthesis Cell envelope biogenesis, outer membrane 91775507 Common - prophage LambdaMc01, site-specific recombinase, resolvase family Mfla_1154 10 None None None 91774625 Common rplA 50S ribosomal protein L1 Mfla_0269 238 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 91775638 Common - hypothetical protein Mfla_1285 39 COG2831 FhaC, Hemolysin activation/secretion protein Intracellular trafficking and secretion 91775556 Nonpathogen - protein of unknown function DUF1555 Mfla_1203 2 None None None 91776389 Common - von Willebrand factor, type A Mfla_2037 25 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 91775903 Common - thermophilic desulfurizing enzyme, TdsB protein Mfla_1550 27 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 91775639 Common - glutamate dehydrogenase Mfla_1286 174 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 91776227 Common - peptidase M50 Mfla_1875 82 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 91775362 Common - palmitoyl transferase for Lipid A Mfla_1009 14 None None None 91774702 Common - coproporphyrinogen III oxidase Mfla_0346 113 COG0408 HemF, Coproporphyrinogen III oxidase Coenzyme metabolism 91776353 Common - ribosomal protein L35 Mfla_2001 199 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 91774868 Common - preprotein translocase, YajC subunit Mfla_0513 173 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 91776108 Common - elongation factor P Mfla_1755 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 91774461 Common - hypothetical protein Mfla_0105 22 None None None 91776186 Common - putative sulfate transport protein CysZ Mfla_1834 38 COG2981 CysZ, Uncharacterized protein involved in cysteine biosynthesis Amino acid transport and metabolism 91776111 Common - uracil-DNA glycosylase Mfla_1758 41 None None None 91776435 Common - flavin reductase-like, FMN-binding Mfla_2083 74 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 91776618 Common ddl D-alanine--D-alanine ligase Mfla_2266 212 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 91776047 Common - Sporulation related Mfla_1694 28 COG3147 DedD, Uncharacterized protein conserved in bacteria Function unknown 91776053 Common truA tRNA pseudouridine synthase A Mfla_1700 236 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 91774358 Common - DNA polymerase III, beta subunit Mfla_0002 216 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 91777007 Common - hypothetical protein Mfla_2659 6 COG3798 COG3798, Uncharacterized protein conserved in bacteria Function unknown 91776479 Nonpathogen - hypothetical protein Mfla_2127 1 None None None 91776760 Common - Lytic transglycosylase, catalytic Mfla_2410 174 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 91776175 Common - flavodoxin/nitric oxide synthase Mfla_1823 112 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 91774551 Common - lipid A biosynthesis acyltransferase Mfla_0195 106 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 91775301 Common - periplasmic sensor signal transduction histidine kinase Mfla_0948 147 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 91774369 Common - Protein-methionine-S-oxide reductase Mfla_0013 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 91775499 Common - Hemerythrin HHE cation binding region Mfla_1146 13 None None None 91776842 Common - rod shape-determining protein MreC Mfla_2492 147 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 91776985 Common thiG thiazole synthase Mfla_2637 167 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 91774719 Common - UvrD/REP helicase Mfla_0363 231 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 91776457 Common - Integral membrane protein TerC Mfla_2105 120 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 91775512 Common - peptidase M48, Ste24p Mfla_1159 145 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 91775078 Common - Electron-transferring-flavoprotein dehydrogenase Mfla_0725 109 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 91774973 Common - molybdenum-pterin binding domain Mfla_0618 38 COG3585 MopI, Molybdopterin-binding protein Coenzyme metabolism 91776955 Common - virulence protein Mfla_2605 62 COG3943 COG3943, Virulence protein General function prediction only 91776287 Common - CheW protein Mfla_1935 125 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 91774631 Common - 30S ribosomal protein S7 Mfla_0275 247 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 91776146 Common - RND efflux system, outer membrane lipoprotein, NodT Mfla_1794 115 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91775289 Common - Twin-arginine translocation pathway signal Mfla_0936 131 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 91774530 Nonpathogen - hypothetical protein Mfla_0174 1 None None None 91775225 Common - TonB-dependent receptor Mfla_0872 97 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 91777061 Common - hypothetical protein Mfla_2713 5 None None None 91774443 Common - protein of unknown function DUF107 Mfla_0087 8 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 91775214 Common - Peptidase S26A, signal peptidase I Mfla_0861 212 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 91775874 Common - outer membrane chaperone Skp (OmpH) Mfla_1521 88 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 91774432 Common - type II and III secretion system protein Mfla_0076 137 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 91776628 Common - Cell division protein, FtsL -like protein Mfla_2276 27 COG3116 FtsL, Cell division protein Cell division and chromosome partitioning 91776789 Common - Hemolysin-type calcium-binding region Mfla_2439 85 None None None 91776758 Nonpathogen - hypothetical protein Mfla_2408 2 None None None 91776769 Common - type II secretion system protein E Mfla_2419 216 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 91774427 Common - polynucleotide phosphorylase/polyadenylase Mfla_0071 236 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 91775643 Nonpathogen - hypothetical protein Mfla_1290 3 None None None 91774915 Common - molybdenum cofactor synthesis-like protein Mfla_0560 202 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 91775446 Common - hypothetical protein Mfla_1093 13 None None None 91775532 Common - hypothetical protein Mfla_1179 20 COG1359 COG1359, Uncharacterized conserved protein Function unknown 91776772 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Mfla_2422 178 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 91774920 Common - transcriptional regulator, GntR family Mfla_0565 194 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 91775372 Nonpathogen - hypothetical protein Mfla_1019 1 None None None 91776652 Common - PfkB Mfla_2300 111 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 91774776 Common - Lytic transglycosylase, catalytic Mfla_0421 85 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 91776203 Common rumA 23S rRNA 5-methyluridine methyltransferase Mfla_1851 199 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 91774950 Common - hypothetical protein Mfla_0595 21 None None None 91775367 Common - UBA/THIF-type NAD/FAD binding fold Mfla_1014 180 COG1179 COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Coenzyme metabolism 91775176 Nonpathogen - hypothetical protein Mfla_0823 1 None None None 91774563 Nonpathogen - hypothetical protein Mfla_0207 1 None None None 91776780 Common - DoxX Mfla_2430 8 COG2259 COG2259, Predicted membrane protein Function unknown 91774945 Common - hypothetical protein Mfla_0590 72 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 91775500 Common - nuclease (SNase-like) Mfla_1147 88 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 91775220 Common - pyridoxal phosphate biosynthetic protein PdxJ Mfla_0867 139 COG0854 PdxJ, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 91777016 Nonpathogen - hypothetical protein Mfla_2668 1 None None None 91775190 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Mfla_0837 219 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 91776670 Common - TonB-dependent siderophore receptor Mfla_2318 112 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 91777075 Nonpathogen - hypothetical protein Mfla_2727 1 None None None 91774859 Common - Heavy metal efflux pump CzcA Mfla_0504 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 91776132 Nonpathogen - hypothetical protein Mfla_1779 4 None None None 91775488 Common - ABC transporter related Mfla_1135 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 91774669 Common - deoxyuridine 5'-triphosphate nucleotidohydrolase (dut) Mfla_0313 180 COG0756 Dut, dUTPase Nucleotide transport and metabolism 91776292 Common - flagellar motor protein MotA Mfla_1940 118 COG1291 MotA, Flagellar motor component Cell motility and secretion 91776401 Common - proton-translocating NADH-quinone oxidoreductase, chain M Mfla_2049 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 91774838 Common - Adhesin HecA 20-residue repeat x2 Mfla_0483 90 COG3210 FhaB, Large exoproteins involved in heme utilization or adhesion Intracellular trafficking and secretion 91776528 Common - transcriptional regulator, NifA subfamily, Fis Family Mfla_2176 168 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 91776848 Common - aminotransferase, class IV Mfla_2498 186 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 91775723 Common - 4-alpha-glucanotransferase Mfla_1370 13 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 91776038 Common - diguanylate cyclase (GGDEF domain) Mfla_1685 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 91774745 Nonpathogen - hypothetical protein Mfla_0389 1 None None None 91776365 Common - glycosyltransferase, RfaG Mfla_2013 29 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 91775462 Common - glutamyl-Q tRNA(Asp) synthetase Mfla_1109 248 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 91774542 Common - methionyl-tRNA formyltransferase Mfla_0186 216 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 91774454 Common - Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase Mfla_0098 118 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 91774660 Common - DNA-directed RNA polymerase subunit alpha Mfla_0304 217 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 91774830 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Mfla_0475 160 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 91776480 Common - beta-lactamase-like protein Mfla_2128 29 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 91774790 Common - acyltransferase 3 Mfla_0435 78 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 91775773 Nonpathogen - hypothetical protein Mfla_1420 1 COG3898 COG3898, Uncharacterized membrane-bound protein Function unknown 91776266 Common - TatD-related deoxyribonuclease Mfla_1914 237 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 91775979 Common - Ribonuclease R Mfla_1626 198 COG0557 VacB, Exoribonuclease R Transcription 91775522 Common - phospholipase D/Transphosphatidylase Mfla_1169 154 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 91776959 Common - Sucrose-phosphate synthase, glycosyltransferase region Mfla_2610 94 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 91775809 Common - hypothetical protein Mfla_1456 6 None None None 91775423 Common - integration host factor, beta subunit Mfla_1070 209 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 91775075 Common - formate dehydrogenase subunit gamma Mfla_0722 157 COG1905 NuoE, NADH:ubiquinone oxidoreductase 24 kD subunit Energy production and conversion 91775207 Common - hypothetical protein Mfla_0854 23 None None None 91774682 Common - nitrate transport permease Mfla_0326 197 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 91775348 Common - endonuclease III Mfla_0995 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 91776531 Nonpathogen - hypothetical protein Mfla_2179 1 None None None 91775821 Common - Squalene/phytoene synthase Mfla_1468 97 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 91776660 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Mfla_2308 219 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 91774511 Common - inner-membrane translocator Mfla_0155 139 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 91775180 Nonpathogen - hypothetical protein Mfla_0827 2 None None None 91775560 Common - hypothetical protein Mfla_1207 5 None None None 91776814 Common - delta-aminolevulinic acid dehydratase Mfla_2464 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 91775737 Common - DNA mismatch repair protein MutL Mfla_1384 191 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 91776161 Common - protein of unknown function DUF81 Mfla_1809 14 COG0730 COG0730, Predicted permeases General function prediction only 91775483 Common - sodium/hydrogen exchanger Mfla_1130 208 COG4651 RosB, Kef-type K+ transport system, predicted NAD-binding component Inorganic ion transport and metabolism 91774641 Common rpsC 30S ribosomal protein S3 Mfla_0285 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 91775813 Nonpathogen - hypothetical protein Mfla_1460 1 None None None 91775593 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Mfla_1240 129 COG2077 Tpx, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 91774870 Common - CDP-diacylglycerol--serine O-phosphatidyltransferase Mfla_0515 149 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 91774984 Common - cytochrome c oxidase, cbb3-type, subunit I Mfla_0629 151 COG3278 CcoN, Cbb3-type cytochrome oxidase, subunit 1 Posttranslational modification, protein turnover, chaperones 91776892 Common - hypothetical protein Mfla_2542 29 None None None 91775885 Common - PII uridylyl-transferase Mfla_1532 124 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 91774618 Common - protein of unknown function DUF34 Mfla_0262 110 COG0327 COG0327, Uncharacterized conserved protein Function unknown 91776285 Common - methyl-accepting chemotaxis sensory transducer with Pas/Pac sensor Mfla_1933 161 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 91776063 Common - acetylornithine and succinylornithine aminotransferases Mfla_1710 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 91776507 Common - leucyl-tRNA synthetase Mfla_2155 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 91774752 Common - peptidase U32 Mfla_0396 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 91774411 Common rplM 50S ribosomal protein L13 Mfla_0055 233 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 91774636 Common - ribosomal protein L4/L1e Mfla_0280 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 91775292 Common - Radical SAM Mfla_0939 73 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 91774577 Common - permease YjgP/YjgQ Mfla_0221 85 COG0795 COG0795, Predicted permeases General function prediction only 91776606 Common - Formate--tetrahydrofolate ligase Mfla_2254 89 COG2759 MIS1, Formyltetrahydrofolate synthetase Nucleotide transport and metabolism 91775202 Common - hypothetical protein Mfla_0849 11 None None None 91776074 Common - Na+/Pi-cotransporter Mfla_1721 54 COG1283 NptA, Na+/phosphate symporter Inorganic ion transport and metabolism 91776515 Common - 8-amino-7-oxononanoate synthase Mfla_2163 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 91775200 Nonpathogen - hypothetical protein Mfla_0847 5 None None None 91776431 Common - hypothetical protein Mfla_2079 13 None None None 91774671 Common - DNA repair protein RadC Mfla_0315 179 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 91776977 Common - hypothetical protein Mfla_2629 35 COG4340 COG4340, Uncharacterized protein conserved in bacteria Function unknown 91776246 Common - 3-hydroxydecanoyl-(acyl carrier protein) dehydratase Mfla_1894 82 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 91776905 Nonpathogen - hypothetical protein Mfla_2555 1 None None None 91776696 Common ruvB Holliday junction DNA helicase B Mfla_2344 226 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 91776858 Common - UDP-N-acetylmuramate Mfla_2508 209 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 91775853 Common - Thymidylate kinase Mfla_1500 231 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 91774812 Common - glutamine amidotransferase, class-II Mfla_0457 230 COG0067 GltB, Glutamate synthase domain 1 Amino acid transport and metabolism 91776309 Common flgE flagellar hook protein FlgE Mfla_1957 126 COG1749 FlgE, Flagellar hook protein FlgE Cell motility and secretion 91775961 Common - hypothetical protein Mfla_1608 11 None None None 91775404 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Mfla_1051 172 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 91774603 Common hisG ATP phosphoribosyltransferase catalytic subunit Mfla_0247 213 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 91774923 Common alaS alanyl-tRNA synthetase Mfla_0568 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 91776477 Common - MxaD gene product Mfla_2125 25 COG5637 COG5637, Predicted integral membrane protein Function unknown 91777029 Common - sigma-24 (FecI-like) Mfla_2681 131 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 91775387 Nonpathogen - hypothetical protein Mfla_1034 1 None None None 91775034 Common - Tetratricopeptide TPR_2 Mfla_0681 152 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 91775380 Common - small multidrug resistance protein Mfla_1027 144 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 91776002 Common - S-layer protein, putative Mfla_1649 24 COG1548 COG1548, Predicted transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 91775924 Common - adenylate/guanylate cyclase Mfla_1571 80 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 91774912 Common - hypothetical protein Mfla_0557 56 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 91775935 Common - flavoprotein Mfla_1582 17 COG1036 COG1036, Archaeal flavoproteins Energy production and conversion 91776000 Common - aspartate/glutamate/uridylate kinase Mfla_1647 22 COG2054 COG2054, Uncharacterized archaeal kinase related to aspartokinases, uridylate kinases General function prediction only 91774472 Nonpathogen - hypothetical protein Mfla_0116 5 COG4744 COG4744, Uncharacterized conserved protein Function unknown 91775065 Common - hypothetical protein Mfla_0712 42 COG3530 COG3530, Uncharacterized protein conserved in bacteria Function unknown 91775093 Common - Phosphate acetyltransferase Mfla_0740 137 COG0280 Pta, Phosphotransacetylase Energy production and conversion 91775715 Common - transcriptional regulator, TetR family Mfla_1362 77 COG1309 AcrR, Transcriptional regulator Transcription 91775322 Nonpathogen - hypothetical protein Mfla_0969 1 None None None 91775755 Common - putative ZipA related protein, possibly involved in cell division Mfla_1402 20 COG3115 ZipA, Cell division protein Cell division and chromosome partitioning 91777009 Common - ATPase, E1-E2 type Mfla_2661 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 91775390 Common - putative phosphoketolase Mfla_1037 65 COG3957 COG3957, Phosphoketolase Carbohydrate transport and metabolism 91775105 Common - GrpE protein Mfla_0752 227 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 91776866 Common - Glutamate--cysteine ligase GshA Mfla_2516 27 None None None 91774765 Common - Integron integrase Mfla_0410 215 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 91776576 Nonpathogen - hypothetical protein Mfla_2224 1 None None None 91775936 Common - Adenylosuccinate synthase Mfla_1583 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 91775408 Common - two component, sigma54 specific, transcriptional regulator, Fis family Mfla_1055 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 91777022 Common - Sporulation related Mfla_2674 45 COG3087 FtsN, Cell division protein Cell division and chromosome partitioning 91775395 Common - protein of unknown function DUF455 Mfla_1042 46 COG2833 COG2833, Uncharacterized protein conserved in bacteria Function unknown 91775318 Common - glycoside hydrolase, family 24 Mfla_0965 51 COG3772 COG3772, Phage-related lysozyme (muraminidase) General function prediction only 91775544 Nonpathogen - hypothetical protein Mfla_1191 8 None None None 91776440 Common - protein of unknown function DUF343 Mfla_2088 115 COG2835 COG2835, Uncharacterized conserved protein Function unknown 91774715 Common - conserved hypothetical protein 730 Mfla_0359 133 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 91776013 Common - methylene tetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase, putative Mfla_1660 8 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 91776935 Common - secretion protein HlyD Mfla_2585 136 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 91774802 Common - two component transcriptional regulator, LuxR family Mfla_0447 211 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 91775351 Common - hypothetical protein Mfla_0998 23 None None None 91774855 Common - cysteinyl-tRNA synthetase Mfla_0500 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 91776787 Common - Type I secretion membrane fusion protein, HlyD Mfla_2437 126 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 91774377 Nonpathogen - coenzyme PQQ biosynthesis protein A Mfla_0021 1 None None None 91775399 Common - protein of unknown function DUF498 Mfla_1046 46 COG3737 COG3737, Uncharacterized conserved protein Function unknown 91776522 Common - nitrate transport ATP-binding subunits C and D Mfla_2170 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 91775000 Common glyQ glycyl-tRNA synthetase subunit alpha Mfla_0645 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 91776086 Common - beta-lactamase-like protein Mfla_1733 206 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 91775027 Common - hypothetical protein Mfla_0674 44 COG2323 COG2323, Predicted membrane protein Function unknown 91776921 Common - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase Mfla_2571 142 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 91775236 Common - small multidrug resistance protein Mfla_0883 144 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 91775007 Common - uroporphyrin-III C-methyltransferase Mfla_0652 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 91776198 Common - protein of unknown function DUF165 Mfla_1846 73 COG1738 COG1738, Uncharacterized conserved protein Function unknown 91776009 Common - triphosphoribosyl-dephospho-CoA protein Mfla_1656 30 COG1767 CitG, Triphosphoribosyl-dephospho-CoA synthetase Coenzyme metabolism 91775762 Common - ATP-dependent Clp protease, proteolytic subunit ClpP Mfla_1409 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 91776538 Common - Glutaredoxin, GrxC Mfla_2186 112 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 91775666 Common - putative integrase Mfla_1313 15 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 91774425 Common - tRNA pseudouridine synthase B Mfla_0069 245 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 91774863 Common - ATPase AAA-2 Mfla_0508 231 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 91775704 Common - TonB-dependent receptor Mfla_1351 58 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 91775697 Nonpathogen - hypothetical protein Mfla_1344 1 None None None 91776185 Common - Pirin-like protein Mfla_1833 147 COG1741 COG1741, Pirin-related protein General function prediction only 91776007 Common - Orotidine 5'-phosphate decarboxylase Mfla_1654 57 COG0269 SgbH, 3-hexulose-6-phosphate synthase and related proteins Carbohydrate transport and metabolism 91775116 Common - glycosyl transferase, group 1 Mfla_0763 217 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 91774406 Common - (p)ppGpp synthetase I (GTP pyrophosphokinase), SpoT/RelA Mfla_0050 206 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 91775906 Common - DNA polymerase III, epsilon subunit Mfla_1553 231 COG2176 PolC, DNA polymerase III, alpha subunit (gram-positive type) DNA replication, recombination, and repair 91775413 Common dcd deoxycytidine triphosphate deaminase Mfla_1060 149 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 91775044 Nonpathogen - hypothetical protein Mfla_0691 1 None None None 91774692 Common - transcriptional regulator, GntR family Mfla_0336 223 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 91774686 Common - protein serine/threonine phosphatases Mfla_0330 150 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 91775015 Nonpathogen - hypothetical protein Mfla_0660 1 None None None 91775915 Nonpathogen - hypothetical protein Mfla_1562 1 None None None 91776390 Common - hypothetical protein Mfla_2038 8 None None None 91776345 Common - TonB-dependent siderophore receptor Mfla_1993 100 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 91775145 Common - Phosphate transport system permease protein 1 Mfla_0792 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 91776828 Common - protein of unknown function DUF6, transmembrane Mfla_2478 105 COG2962 RarD, Predicted permeases General function prediction only 91775469 Common - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Mfla_1116 194 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 91776919 Nonpathogen - hypothetical protein Mfla_2569 3 None None None 91776767 Common - Fimbrial assembly Mfla_2417 6 None None None 91775089 Common - conserved hypothetical protein 95 Mfla_0736 212 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 91774917 Common - 4Fe-4S ferredoxin, iron-sulfur binding Mfla_0562 150 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 91775792 Common - hypothetical protein Mfla_1439 9 None None None 91776193 Nonpathogen - hypothetical protein Mfla_1841 1 None None None 91774788 Common - nitrogen regulatory protein P-II (GlnB, GlnK) Mfla_0433 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 91776438 Common - Cobyrinic acid a,c-diamide synthase Mfla_2086 187 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 91774980 Common - hypothetical protein Mfla_0625 29 COG4391 COG4391, Uncharacterized protein conserved in bacteria Function unknown 91775712 Common - RND efflux system, outer membrane lipoprotein, NodT Mfla_1359 113 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 91777038 Common - hypothetical protein Mfla_2690 4 None None None 91775533 Common - transcriptional regulator, AraC family Mfla_1180 92 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 91775828 Common - ribosome-associated GTPase Mfla_1475 163 COG1162 COG1162, Predicted GTPases General function prediction only 91774623 Common - NusG antitermination factor Mfla_0267 215 COG0250 NusG, Transcription antiterminator Transcription 91774738 Common - hypothetical protein Mfla_0382 15 COG4390 COG4390, Uncharacterized protein conserved in bacteria Function unknown 91774565 Common - sodium:dicarboxylate symporter Mfla_0209 163 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 91776677 Common - ribosomal protein S21 Mfla_2325 103 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 91775832 Common - ribonuclease H Mfla_1479 177 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 91774479 Nonpathogen - hypothetical protein Mfla_0123 6 None None None 91775439 Common - cytochrome d ubiquinol oxidase, subunit II Mfla_1086 155 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 91776803 Common - hypothetical protein Mfla_2453 14 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 91776591 Common - ABC-2 Mfla_2239 17 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 91774633 Common - elongation factor Tu Mfla_0277 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 91776616 Common - cell division protein FtsA Mfla_2264 199 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 91775727 Nonpathogen - hypothetical protein Mfla_1374 2 None None None 91776795 Common - shikimate 5-dehydrogenase Mfla_2445 221 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 91775748 Common - putative phage repressor Mfla_1395 20 COG2932 COG2932, Predicted transcriptional regulator Transcription 91776544 Common - hypothetical protein Mfla_2192 10 COG2847 COG2847, Uncharacterized protein conserved in bacteria Function unknown 91776127 Common - inner-membrane translocator Mfla_1774 150 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 91774588 Common - GTPase EngB Mfla_0232 181 COG0218 COG0218, Predicted GTPase General function prediction only 91775331 Common - DNA mismatch repair protein MutS Mfla_0978 203 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 91776554 Common - response regulator receiver domain protein (CheY-like) Mfla_2202 221 COG4567 COG4567, Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain Signal transduction mechanisms / Transcription 91774891 Nonpathogen - hypothetical protein Mfla_0536 1 None None None 91776313 Common flgI flagellar basal body P-ring protein Mfla_1961 104 COG1706 FlgI, Flagellar basal-body P-ring protein Cell motility and secretion 91775267 Common - Dihydrofolate reductase Mfla_0914 146 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 91776459 Common - twitching motility protein Mfla_2107 221 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 91776809 Common - Pilus assembly protein, PilO Mfla_2459 48 COG3167 PilO, Tfp pilus assembly protein PilO Cell motility and secretion / Intracellular trafficking and secretion 91775710 Nonpathogen - hypothetical protein Mfla_1357 1 None None None 91776944 Common - Uracil-DNA glycosylase superfamily Mfla_2594 128 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 91775632 Common - UTP-glucose-1-phosphate uridylyltransferase Mfla_1279 232 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 91776681 Common - Tyrosine recombinase XerD Mfla_2329 232 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 91774768 Common - ribosomal-protein-alanine acetyltransferase Mfla_0413 199 COG0456 RimI, Acetyltransferases General function prediction only 91776384 Common - 2OG-Fe(II) oxygenase Mfla_2032 31 COG3751 EGL-9, Predicted proline hydroxylase Posttranslational modification, protein turnover, chaperones 91774606 Common - Orotidine 5'-phosphate decarboxylase Mfla_0250 57 COG0269 SgbH, 3-hexulose-6-phosphate synthase and related proteins Carbohydrate transport and metabolism 91774970 Common - Serine O-acetyltransferase Mfla_0615 192 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 91776715 Common - protein of unknown function UPF0047 Mfla_2363 123 COG0432 COG0432, Uncharacterized conserved protein Function unknown 91774470 Common - periplasmic binding protein Mfla_0114 148 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 91774943 Common - short-chain dehydrogenase/reductase SDR Mfla_0588 238 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 91775669 Common - hypothetical protein Mfla_1316 2 None None None 91774895 Common - transcriptional regulator, AraC family Mfla_0540 54 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 91776336 Common - flagellar hook-associated 2-like protein Mfla_1984 132 COG1345 FliD, Flagellar capping protein Cell motility and secretion 91776550 Common - ATPase AAA-2 Mfla_2198 222 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 91774616 Common - Sec-independent protein translocase TatC Mfla_0260 205 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 91775789 Common - Catalase Mfla_1436 47 COG3546 COG3546, Mn-containing catalase Inorganic ion transport and metabolism 91776258 Common - hypothetical protein Mfla_1906 46 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 91776143 Common - Alpha/beta hydrolase fold-3 Mfla_1791 113 COG0657 Aes, Esterase/lipase Lipid metabolism 91776233 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Mfla_1881 162 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 91776717 Common - protein of unknown function DUF140 Mfla_2365 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 91774508 Common - Twin-arginine translocation pathway signal Mfla_0152 23 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 91775741 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Mfla_1388 166 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 91776688 Common - Radical SAM Mfla_2336 170 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 91775138 Common - phosphoglucosamine mutase Mfla_0785 242 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 91776158 Common - cation diffusion facilitator family transporter Mfla_1806 184 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 91775238 Common - Endonuclease/exonuclease/phosphatase Mfla_0885 25 COG3021 COG3021, Uncharacterized protein conserved in bacteria Function unknown 91775330 Common - TonB-dependent receptor Mfla_0977 73 COG4772 FecA, Outer membrane receptor for Fe3+-dicitrate Inorganic ion transport and metabolism 91775611 Common - DEAD/DEAH box helicase-like protein Mfla_1258 240 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 91774527 Common - hypothetical protein Mfla_0171 16 None None None 91777000 Common - 1-aminocyclopropane-1-carboxylate deaminase-like protein Mfla_2652 9 COG2515 Acd, 1-aminocyclopropane-1-carboxylate deaminase Amino acid transport and metabolism 91775880 Common - ribosome recycling factor Mfla_1527 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 91775527 Common - protein of unknown function DUF45 Mfla_1174 113 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 91775165 Common - RNA methyltransferase TrmH, group 1 Mfla_0812 162 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 91775570 Common - hypothetical protein Mfla_1217 4 None None None 91775324 Nonpathogen - hypothetical protein Mfla_0971 2 None None None 91775020 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC and GAF sensor(s) Mfla_0665 188 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 91775219 Common recO DNA repair protein RecO Mfla_0866 60 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 91775455 Common - alkylphosphonate utilization operon protein PhnA Mfla_1102 93 COG2824 PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism Inorganic ion transport and metabolism 91776399 Common - hypothetical protein Mfla_2047 16 None None None 91776114 Common - two component transcriptional regulator, LuxR family Mfla_1761 224 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 91776448 Nonpathogen - hypothetical protein Mfla_2096 2 None None None 91776045 Common - amidophosphoribosyltransferase Mfla_1692 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 91776155 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Mfla_1803 201 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 91774593 Common - ABC transporter related Mfla_0237 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 91776205 Common - hypothetical protein Mfla_1853 9 COG3459 COG3459, Cellobiose phosphorylase Carbohydrate transport and metabolism 91776299 Common - hypothetical protein Mfla_1947 26 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 91775115 Common - toluene tolerance protein, putative Mfla_0762 3 None None None 91774509 Common - ABC transporter related Mfla_0153 248 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 91775609 Common - globin Mfla_1256 69 COG2346 COG2346, Truncated hemoglobins General function prediction only 91774997 Common - phospholipid/glycerol acyltransferase Mfla_0642 162 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 91776463 Common - NADP oxidoreductase, coenzyme F420-dependent Mfla_2111 49 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 91774463 Nonpathogen - hypothetical protein Mfla_0107 1 None None None 91776871 Nonpathogen - hypothetical protein Mfla_2521 4 COG4967 PilV, Tfp pilus assembly protein PilV Cell motility and secretion / Intracellular trafficking and secretion 91776092 Common - glycosyl transferase, group 1 Mfla_1739 92 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 91775364 Common - pyridoxal phosphate biosynthetic protein PdxJ Mfla_1011 139 COG0854 PdxJ, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 91775787 Common - cytochrome c oxidase, subunit I Mfla_1434 123 COG3278 CcoN, Cbb3-type cytochrome oxidase, subunit 1 Posttranslational modification, protein turnover, chaperones 91775608 Common purT phosphoribosylglycinamide formyltransferase 2 Mfla_1255 183 COG0027 PurT, Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) Nucleotide transport and metabolism 91776957 Common - protein of unknown function DUF450 Mfla_2607 118 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 91776643 Common - ribosomal protein L31 Mfla_2291 176 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 91774818 Common amiE acylamide amidohydrolase Mfla_0463 75 COG0388 COG0388, Predicted amidohydrolase General function prediction only 91775517 Common - hypothetical protein Mfla_1164 8 None None None 91775573 Common - type I restriction-modification system, M subunit Mfla_1220 160 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 91774902 Nonpathogen - hypothetical protein Mfla_0547 2 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 91776964 Common - ProQ activator of osmoprotectant transporter ProP Mfla_2615 4 COG3109 ProQ, Activator of osmoprotectant transporter ProP Signal transduction mechanisms 91774825 Common - 17 kDa surface antigen Mfla_0470 30 COG3133 SlyB, Outer membrane lipoprotein Cell envelope biogenesis, outer membrane 91775076 Common - FAD linked oxidase-like protein Mfla_0723 201 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 91776148 Common - transport-associated Mfla_1796 27 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 91774553 Common - protein of unknown function DUF484 Mfla_0197 54 COG3159 COG3159, Uncharacterized protein conserved in bacteria Function unknown 91774975 Common - Thiosulphate-binding protein Mfla_0620 90 COG1613 Sbp, ABC-type sulfate transport system, periplasmic component Inorganic ion transport and metabolism 91776509 Common - DNA polymerase III, delta subunit Mfla_2157 89 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 91775216 Common - Ribonuclease III Mfla_0863 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 91774703 Common - SUA5/yciO/yrdC-like protein Mfla_0347 234 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 91776135 Common - hypothetical protein Mfla_1783 58 COG3174 COG3174, Predicted membrane protein Function unknown 91776586 Common - preprotein translocase, SecA subunit Mfla_2234 216 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 91775374 Common - MotA/TolQ/ExbB proton channel Mfla_1021 147 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 91776770 Common - type II secretion system protein Mfla_2420 140 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 91774861 Common - Dihydroorotate oxidase Mfla_0506 233 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 91775054 Nonpathogen - cytochrome oxidase maturation protein, cbb3-type Mfla_0701 2 COG3197 FixS, Uncharacterized protein, possibly involved in nitrogen fixation Inorganic ion transport and metabolism 91775178 Nonpathogen - hypothetical protein Mfla_0825 1 None None None 91775569 Common - restriction modification system DNA specificity domain Mfla_1216 70 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 91774849 Common - FHA domain containing protein Mfla_0494 66 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 91775510 Nonpathogen - hypothetical protein Mfla_1157 3 None None None 91775670 Common - hypothetical protein Mfla_1317 10 COG3184 COG3184, Uncharacterized protein conserved in bacteria Function unknown 91775255 Common - protein of unknown function DUF498 Mfla_0902 46 COG3737 COG3737, Uncharacterized conserved protein Function unknown 91776450 Common - 3,4-dihydroxy-2-butanone 4-phosphate synthase Mfla_2098 229 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 91774362 Common - glycoside hydrolase family 2, sugar binding Mfla_0006 80 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 91776979 Common - Entericidin EcnAB Mfla_2631 5 COG5510 COG5510, Predicted small secreted protein Function unknown 91774720 Common - chaperonin GroEL Mfla_0364 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 91775541 Common - cold-shock DNA-binding domain protein Mfla_1188 177 COG1278 CspC, Cold shock proteins Transcription 91776659 Common - periplasmic sensor signal transduction histidine kinase Mfla_2307 137 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 91774535 Common - aquaporin Z Mfla_0179 127 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 91774727 Nonpathogen - hypothetical protein Mfla_0371 1 None None None 91776359 Common - UDP-glucose 4-epimerase Mfla_2007 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 91775279 Common - integration host factor, beta subunit Mfla_0926 209 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 91776774 Common - single-strand binding protein Mfla_2424 213 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 91775227 Common rpsD 30S ribosomal protein S4 Mfla_0874 234 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 91774645 Common rplN 50S ribosomal protein L14 Mfla_0289 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 91774774 Nonpathogen - hypothetical protein Mfla_0419 1 None None None 91777063 Common - hypothetical protein Mfla_2715 4 COG5185 HEC1, Protein involved in chromosome segregation, interacts with SMC proteins Cell division and chromosome partitioning 91776650 Common - hypothetical protein Mfla_2298 11 COG5479 COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis Cell envelope biogenesis, outer membrane 91775872 Common - beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ Mfla_1519 186 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 91774494 Common - Phosphatase kdsC Mfla_0138 102 COG1778 COG1778, Low specificity phosphatase (HAD superfamily) General function prediction only 91776726 Common - putative redox protein Mfla_2376 82 COG2945 COG2945, Predicted hydrolase of the alpha/beta superfamily General function prediction only 91777093 Common - ATP synthase F1, gamma subunit Mfla_2745 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 91776492 Common - cold-shock DNA-binding domain protein Mfla_2140 181 COG1278 CspC, Cold shock proteins Transcription 91775168 Common - two component transcriptional regulator, LuxR family Mfla_0815 204 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 91777077 Common - hypothetical protein Mfla_2729 13 COG5566 COG5566, Uncharacterized conserved protein Function unknown 91775066 Nonpathogen - hypothetical protein Mfla_0713 1 None None None 91775588 Common - spermidine synthase Mfla_1235 57 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 91776734 Common aspS aspartyl-tRNA synthetase Mfla_2384 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 91775703 Nonpathogen - hypothetical protein Mfla_1350 1 None None None 91775222 Nonpathogen - hypothetical protein Mfla_0869 1 None None None 91775968 Common - Pyrrolo-quinoline quinone Mfla_1615 115 COG1520 COG1520, FOG: WD40-like repeat Function unknown 91775250 Common - hypothetical protein Mfla_0897 32 COG3497 COG3497, Phage tail sheath protein FI General function prediction only 91776032 Common - phosphoadenosine phosphosulfate reductase Mfla_1679 116 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 91774496 Common - OstA-like protein Mfla_0140 66 COG1934 COG1934, Uncharacterized protein conserved in bacteria Function unknown 91775241 Common - Ankyrin Mfla_0888 45 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 91775991 Common - type II secretion system protein Mfla_1638 69 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 91776375 Common - hypothetical protein Mfla_2023 35 None None None 91775654 Common - 2OG-Fe(II) oxygenase Mfla_1301 56 COG3145 AlkB, Alkylated DNA repair protein DNA replication, recombination, and repair 91776441 Common - tetraacyldisaccharide 4'-kinase Mfla_2089 126 COG1663 LpxK, Tetraacyldisaccharide-1-P 4'-kinase Cell envelope biogenesis, outer membrane 91776106 Common - GreA/GreB family elongation factor Mfla_1753 196 COG0782 GreA, Transcription elongation factor Transcription 91775636 Common - PAS/PAC sensor signal transduction histidine kinase Mfla_1283 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 91775986 Common - hypothetical protein Mfla_1633 4 None None None 91776634 Common - Putative lipoprotein-like protein Mfla_2282 44 COG3107 LppC, Putative lipoprotein General function prediction only 91776025 Common - Uncharacterised conserved protein UCP030820 Mfla_1672 46 COG3749 COG3749, Uncharacterized protein conserved in bacteria Function unknown 91776751 Common - TonB-dependent receptor, putative Mfla_2401 7 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 91776327 Common - ATPase FliI/YscN Mfla_1975 247 COG1157 FliI, Flagellar biosynthesis/type III secretory pathway ATPase Cell motility and secretion / Intracellular trafficking and secretion 91775901 Common - ABC transporter related Mfla_1548 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 91774786 Common - Peptidoglycan-binding LysM Mfla_0431 21 COG4254 COG4254, Uncharacterized protein conserved in bacteria Function unknown 91776040 Common - phosphoserine aminotransferase Mfla_1687 114 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 91776273 Common - Phosphoglucomutase Mfla_1921 242 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 91776422 Common - hypothetical protein Mfla_2070 15 None None None 91775581 Common - hypothetical protein Mfla_1228 13 None None None 91774963 Common - putative signaling membrane protein Mfla_0608 161 COG4943 COG4943, Predicted signal transduction protein containing sensor and EAL domains Signal transduction mechanisms 91776626 Common - UDP-N-acetylmuramyl-tripeptide synthetases Mfla_2274 213 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 91775684 Common - alanine racemase Mfla_1331 199 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 91775687 Common - methylation Mfla_1334 13 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 91775436 Common - Radical SAM Mfla_1083 73 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 91777104 Common - protein of unknown function DUF1555 Mfla_2756 5 None None None 91774575 Common - hypothetical protein Mfla_0219 19 None None None 91776351 Common - phenylalanyl-tRNA synthetase, alpha subunit Mfla_1999 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 91775272 Common - 6-phosphogluconolactonase Mfla_0919 138 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 91776166 Common - beta-lactamase-like protein Mfla_1814 214 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 91775942 Common - Host factor Hfq Mfla_1589 127 COG1923 Hfq, Uncharacterized host factor I protein General function prediction only 91775868 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Mfla_1515 135 COG0313 COG0313, Predicted methyltransferases General function prediction only 91775649 Common - proteinase inhibitor I11, ecotin Mfla_1296 23 COG4574 Eco, Serine protease inhibitor ecotin General function prediction only 91776229 Common - PHP-like protein Mfla_1877 121 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 91775287 Nonpathogen - hypothetical protein Mfla_0934 1 None None None 91777080 Common - Sel1 Mfla_2732 99 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 91774520 Common - hypothetical protein Mfla_0164 6 None None None 91776113 Common - CheW protein Mfla_1760 35 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 91775896 Common - HAD-superfamily hydrolase subfamily IA, variant 3 Mfla_1543 129 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 91774458 Common cobD cobalamin biosynthesis protein Mfla_0102 154 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 91775419 Common - Competence protein ComEA helix-hairpin-helix region Mfla_1066 137 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 91775474 Nonpathogen - hypothetical protein Mfla_1121 1 None None None 91775956 Common - TonB-dependent receptor, plug Mfla_1603 63 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 91774840 Common - protein of unknown function UPF0060 Mfla_0485 80 COG1742 COG1742, Uncharacterized conserved protein Function unknown 91774638 Common rplB 50S ribosomal protein L2 Mfla_0282 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis