Frankia sp. CcI3, complete genome NC_007777 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 86739902 Common - putative transcriptional regulator Francci3_1195 7 None None None 86742440 Common - signal transduction histidine kinase Francci3_3760 88 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 86740509 Common - ribonucleotide reductase large subunit Francci3_1804 47 None None None 86743130 Nonpathogen - hypothetical protein Francci3_4455 1 None None None 86739708 Nonpathogen - hypothetical protein Francci3_0996 1 None None None 86739497 Nonpathogen - hypothetical protein Francci3_0784 2 None None None 86740151 Common - thioesterase superfamily Francci3_1445 33 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 86741658 Nonpathogen - hypothetical protein Francci3_2972 2 None None None 86739965 Common - ComEC/Rec2-related protein Francci3_1258 126 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 86739130 Common - putative ryanodine receptor Francci3_0414 3 None None None 86738993 Common - transposase IS66 Francci3_0277 47 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739507 Common - Nitrite reductase (NAD(P)H) large subunit, NirB Francci3_0794 199 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 86741669 Common - ABC transporter related Francci3_2983 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 86742907 Common - nitroreductase Francci3_4232 42 COG0778 NfnB, Nitroreductase Energy production and conversion 86739724 Common - protein of unknown function DUF323 Francci3_1012 78 COG1262 COG1262, Uncharacterized conserved protein Function unknown 86742688 Common - transposase, IS4 Francci3_4009 49 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740553 Nonpathogen - hypothetical protein Francci3_1848 1 None None None 86738920 Common - Tetracyclin repressor-like Francci3_0201 4 None None None 86741257 Common - hypothetical protein Francci3_2566 9 None None None 86739336 Nonpathogen - hypothetical protein Francci3_0623 1 None None None 86743125 Common - peptidase C2, calpain Francci3_4450 3 None None None 86741943 Common - Cellulose synthase (UDP-forming) Francci3_3257 114 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86741491 Common - Citrate lyase Francci3_2804 110 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 86741432 Nonpathogen - hypothetical protein Francci3_2743 1 None None None 86742262 Common - ribosomal protein S2 Francci3_3581 232 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 86741218 Common - diguanylate cyclase (GGDEF domain) Francci3_2523 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 86743183 Common - mycothiol-dependent maleylpyruvate isomerase Francci3_4508 11 None None None 86738899 Common - MscS Mechanosensitive ion channel Francci3_0178 43 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 86739340 Common - peptidase M22, glycoprotease Francci3_0627 160 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 86742361 Common - putative pep2 protein Francci3_3680 58 COG3281 Ble, Uncharacterized protein, probably involved in trehalose biosynthesis Carbohydrate transport and metabolism 86742919 Common - formylmethionine deformylase Francci3_4244 200 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 86743067 Common - hypothetical protein Francci3_4392 16 None None None 86739337 Common - Glycine hydroxymethyltransferase Francci3_0624 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 86739686 Common - Methyltransferase type 11 Francci3_0973 192 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86740141 Nonpathogen - hypothetical protein Francci3_1435 1 None None None 86739781 Common - hydrogenase expression/formation protein HypD Francci3_1070 108 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 86741170 Common - lipid-transfer protein Francci3_2474 120 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 86742302 Common - isopropylmalate isomerase large subunit Francci3_3621 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 86739352 Nonpathogen - hypothetical protein Francci3_0639 1 COG5373 COG5373, Predicted membrane protein Function unknown 86739830 Common - hypothetical protein Francci3_1121 15 None None None 86741115 Common - Acyl-CoA dehydrogenase Francci3_2419 130 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 86741386 Common - hypothetical protein Francci3_2696 5 None None None 86738762 Nonpathogen - hypothetical protein Francci3_0039 1 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 86738892 Common - glycosyl transferase, group 1 Francci3_0171 160 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86738780 Common - Transketolase Francci3_0057 194 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 86739271 Common - nucleotide-binding protein Francci3_0558 107 COG1666 COG1666, Uncharacterized protein conserved in bacteria Function unknown 86740245 Common - Methyltransferase type 12 Francci3_1540 15 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86742929 Common - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Francci3_4254 183 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 86739690 Common - periplasmic sensor signal transduction histidine kinase Francci3_0977 208 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 86742698 Nonpathogen - hypothetical protein Francci3_4019 1 None None None 86740324 Common - Extracellular ligand-binding receptor Francci3_1619 110 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 86742047 Common - DegT/DnrJ/EryC1/StrS aminotransferase Francci3_3363 192 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 86741279 Nonpathogen - hypothetical protein Francci3_2588 2 COG1141 Fer, Ferredoxin Energy production and conversion 86741298 Common - twin-arginine translocation protein, TatA/E family Francci3_2607 6 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 86740163 Common - phospholipid/glycerol acyltransferase Francci3_1457 116 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 86741811 Common - transcriptional regulator, TetR family Francci3_3125 22 COG1309 AcrR, Transcriptional regulator Transcription 86741235 Common - hypothetical protein Francci3_2542 3 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 86739616 Nonpathogen - hypothetical protein Francci3_0903 1 None None None 86741041 Common - DNA methylase N-4/N-6 Francci3_2345 107 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 86741226 Nonpathogen - hypothetical protein Francci3_2532 1 None None None 86743072 Common - threonine synthase Francci3_4397 196 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 86740954 Common - hypothetical protein Francci3_2257 56 COG2187 COG2187, Uncharacterized protein conserved in bacteria Function unknown 86741439 Nonpathogen - hypothetical protein Francci3_2750 1 None None None 86742416 Common - hypothetical protein Francci3_3736 6 None None None 86739730 Common - ISRSO5-transposase protein Francci3_1018 48 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742654 Common - sulphate transporter Francci3_3975 160 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 86742223 Common - cell divisionFtsK/SpoIIIE Francci3_3542 198 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 86740305 Common - putative ferredoxin Francci3_1600 14 COG1141 Fer, Ferredoxin Energy production and conversion 86738945 Nonpathogen - hypothetical protein Francci3_0227 1 None None None 86741343 Common - hypothetical protein Francci3_2652 4 None None None 86742613 Common - short-chain dehydrogenase/reductase SDR Francci3_3934 232 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 86741285 Common - transcriptional regulator, TetR family Francci3_2594 14 COG1309 AcrR, Transcriptional regulator Transcription 86741829 Common - Glutamate--ammonia ligase Francci3_3143 152 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 86738845 Common - transposase, IS4 Francci3_0122 28 None None None 86741734 Nonpathogen - hypothetical protein Francci3_3048 1 None None None 86742890 Common - insertion element conserved hypothetical protein Francci3_4214 18 None None None 86741869 Common - hypothetical protein Francci3_3183 10 None None None 86740326 Common - DNA polymerase I Francci3_1621 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 86742545 Common - NUDIX hydrolase Francci3_3866 136 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 86742667 Nonpathogen - hypothetical protein Francci3_3988 1 None None None 86742759 Common dnaE DNA polymerase III subunit alpha Francci3_4082 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 86740930 Common - transcriptional repressor, CopY family Francci3_2233 12 COG3682 COG3682, Predicted transcriptional regulator Transcription 86742561 Common fumC fumarate hydratase Francci3_3882 237 COG0114 FumC, Fumarase Energy production and conversion 86740784 Nonpathogen - hypothetical protein Francci3_2083 4 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 86742344 Common - Acetate--CoA ligase Francci3_3663 213 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 86743053 Common - nicotinate-nucleotide pyrophosphorylase Francci3_4378 201 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 86739177 Common - binding-protein-dependent transport systems inner membrane component Francci3_0462 142 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 86740798 Nonpathogen - hypothetical protein Francci3_2097 1 None None None 86740175 Common - transcriptional regulator, MerR family Francci3_1469 18 COG0789 SoxR, Predicted transcriptional regulators Transcription 86741760 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Francci3_3074 126 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 86739436 Common - ABC transporter related Francci3_0723 245 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 86739700 Common - carboxyl transferase Francci3_0988 57 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 86740298 Common - AMP-dependent synthetase and ligase Francci3_1593 163 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86741528 Common - Zeta toxin Francci3_2841 11 COG4185 COG4185, Uncharacterized protein conserved in bacteria Function unknown 86742641 Common - ribose-phosphate pyrophosphokinase Francci3_3962 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 86743141 Nonpathogen - putative O-methyltransferase Francci3_4466 4 None None None 86739467 Common - Twin-arginine translocation pathway signal Francci3_0754 202 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 86739852 Common - phage integrase Francci3_1144 100 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86740026 Common - nucleic acid binding, OB-fold, tRNA/helicase-type Francci3_1320 12 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 86740687 Common - short chain dehydrogenase Francci3_1984 205 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 86739884 Common - Stage II sporulation E Francci3_1176 73 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 86742259 Common - phosphatidate cytidylyltransferase Francci3_3578 215 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 86739108 Common - transposase, IS4 Francci3_0392 30 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86741250 Common - ThiJ/PfpI Francci3_2559 73 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 86742269 Common rnhB ribonuclease HII Francci3_3588 216 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 86742712 Common - protein of unknown function DUF574 Francci3_4033 12 None None None 86742533 Common - Undecaprenyl-phosphate galactosephosphotransferase Francci3_3854 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 86742697 Nonpathogen - protein of unknown function DUF955 Francci3_4018 3 COG2856 COG2856, Predicted Zn peptidase Amino acid transport and metabolism 86739949 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Francci3_1242 205 COG0388 COG0388, Predicted amidohydrolase General function prediction only 86739756 Common - hypothetical protein Francci3_1045 6 COG4278 COG4278, Uncharacterized conserved protein Function unknown 86742594 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding Francci3_3915 10 COG3871 COG3871, Uncharacterized stress protein (general stress protein 26) General function prediction only 86742727 Common - response regulator receiver protein Francci3_4048 221 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 86738913 Common - type I restriction-modification system specificity determinant Francci3_0193 87 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 86742687 Common - putative IS1648 transposase Francci3_4008 70 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741006 Common - hypothetical protein Francci3_2309 7 None None None 86739264 Common - NADH dehydrogenase subunit N Francci3_0551 210 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 86740111 Common - AAA_3 ATPase associated with various cellular activities Francci3_1405 175 COG0714 COG0714, MoxR-like ATPases General function prediction only 86741422 Common - transposase IS3/IS911 Francci3_2733 4 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740390 Nonpathogen - hypothetical protein Francci3_1685 1 None None None 86740833 Nonpathogen - hypothetical protein Francci3_2132 1 COG3393 COG3393, Predicted acetyltransferase General function prediction only 86742922 Nonpathogen - hypothetical protein Francci3_4247 1 None None None 86743121 Common - glucose-methanol-choline oxidoreductase Francci3_4446 52 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 86741853 Common - DNA-3-methyladenine glycosylase Francci3_3167 78 COG2094 Mpg, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 86739866 Nonpathogen - hypothetical protein Francci3_1158 1 None None None 86739613 Common - NUDIX hydrolase Francci3_0900 56 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 86741516 Common - HNH endonuclease Francci3_2829 7 None None None 86742308 Nonpathogen - hypothetical protein Francci3_3627 1 None None None 86741751 Common - stress protein Francci3_3065 29 COG2310 TerZ, Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 Signal transduction mechanisms 86739207 Nonpathogen - hypothetical protein Francci3_0492 1 None None None 86739188 Common - Xylose isomerase-like Francci3_0473 19 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 86739359 Common - Pyridoxal-5'-phosphate-dependent enzyme, beta subunit Francci3_0646 186 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 86741713 Common hisD histidinol dehydrogenase Francci3_3027 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 86742324 Nonpathogen - hypothetical protein Francci3_3643 1 None None None 86740236 Nonpathogen - hypothetical protein Francci3_1531 3 None None None 86739678 Common - Glycosyltransferases probably involved in cell wall biogenesis-like Francci3_0965 88 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86740849 Nonpathogen - hypothetical protein Francci3_2148 6 None None None 86741707 Common - Phosphoribosyl-AMP cyclohydrolase Francci3_3021 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 86742038 Common - protein of unknown function DUF820 Francci3_3352 9 COG4636 Uma2, Uncharacterized protein conserved in cyanobacteria Function unknown 86741617 Common - Beta-hydroxyacyl dehydratase FabA/FabZ Francci3_2930 59 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 86740088 Common - seryl-tRNA synthetase Francci3_1382 243 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 86740957 Common - DEAD/DEAH box helicase-like Francci3_2260 124 COG4581 COG4581, Superfamily II RNA helicase DNA replication, recombination, and repair 86741913 Nonpathogen - hypothetical protein Francci3_3227 1 None None None 86741140 Common - two component transcriptional regulator, winged helix family Francci3_2444 216 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86741216 Common - Methane monooxygenase Francci3_2520 19 None None None 86739458 Common fbiC FO synthase Francci3_0745 82 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 86738743 Common - CRISPR-associated protein, CT1975 Francci3_0020 42 None None None 86740058 Common - band 7 protein Francci3_1352 217 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 86741788 Common - histidine triad (HIT) protein Francci3_3102 196 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 86741975 Common - protein of unknown function DUF72 Francci3_3289 102 COG1801 COG1801, Uncharacterized conserved protein Function unknown 86742988 Common - hypoxanthine phosphoribosyltransferase Francci3_4313 161 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 86739484 Common - putative transcriptional regulator Francci3_0771 8 COG3311 AlpA, Predicted transcriptional regulator Transcription 86739028 Common - putative transcriptional regulator Francci3_0312 37 COG2378 COG2378, Predicted transcriptional regulator Transcription 86743037 Common - Allergen V5/Tpx-1 related Francci3_4362 74 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 86740414 Nonpathogen - hypothetical protein Francci3_1709 1 None None None 86739923 Common - Radical SAM Francci3_1216 64 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 86742638 Common - ABC transporter related Francci3_3959 248 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 86741771 Common - Phosphofructokinase, pyrophosphate dependent Francci3_3085 161 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 86739716 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) Francci3_1004 183 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 86740335 Common - beta-lactamase-like Francci3_1630 200 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 86742558 Nonpathogen - exodeoxyribonuclease VII, small subunit Francci3_3879 1 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 86740135 Common - ABC transporter related Francci3_1429 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 86738750 Common - hypothetical protein Francci3_0027 8 None None None 86740917 Common - hypothetical protein Francci3_2219 4 None None None 86740180 Nonpathogen - hypothetical protein Francci3_1474 2 None None None 86740528 Nonpathogen - putative O-methyltransferase Francci3_1823 3 None None None 86738776 Common - acyl-CoA dehydrogenase-like Francci3_0053 146 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 86742886 Common - Integrase Francci3_4210 64 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 86740937 Common - Alcohol dehydrogenase, zinc-binding Francci3_2240 208 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 86741772 Common - hypothetical protein Francci3_3086 7 None None None 86741024 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Francci3_2327 26 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 86742584 Common - magnesium chelatase, ChlI subunit Francci3_3905 39 COG1239 ChlI, Mg-chelatase subunit ChlI Coenzyme metabolism 86742804 Nonpathogen - hypothetical protein Francci3_4127 1 None None None 86742719 Common - UTP-glucose-1-phosphate uridylyltransferase Francci3_4040 229 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 86743093 Common - hypothetical protein Francci3_4418 18 None None None 86742214 Nonpathogen - hypothetical protein Francci3_3533 3 None None None 86741030 Nonpathogen - hypothetical protein Francci3_2333 2 None None None 86741504 Common - Superoxide dismutase Francci3_2817 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 86741134 Common - hypothetical protein Francci3_2438 2 COG3941 COG3941, Mu-like prophage protein General function prediction only 86743194 Common - ribosomal protein L9 Francci3_4519 215 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 86741835 Common - 3-methyl-2-oxobutanoate hydroxymethyltransferase Francci3_3149 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 86739371 Nonpathogen - hypothetical protein Francci3_0658 1 None None None 86739655 Common - transcriptional regulator, TetR family Francci3_0942 11 COG1309 AcrR, Transcriptional regulator Transcription 86740738 Common - NAD-dependent epimerase/dehydratase Francci3_2035 31 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 86739362 Common - Acetyl-CoA carboxylase beta subunit-like Francci3_0649 18 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 86741987 Nonpathogen - hypothetical protein Francci3_3301 1 None None None 86740373 Common - glycogen synthase Francci3_1668 220 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86739238 Common - Ferredoxin--nitrite reductase Francci3_0525 177 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 86740660 Nonpathogen - hypothetical protein Francci3_1956 1 None None None 86739098 Common - ABC transporter related Francci3_0382 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 86742251 Common - ABC transporter related Francci3_3570 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 86741905 Common - glutamyl-tRNA synthetase Francci3_3219 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 86739021 Common - histidine kinase, dimerisation and phosphoacceptor region Francci3_0305 13 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 86740727 Common - putative transposase Francci3_2024 12 None None None 86741640 Common - putative DNA methylase Francci3_2953 38 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 86740674 Nonpathogen - hypothetical protein Francci3_1971 1 None None None 86742394 Common - ATP synthase F0, A subunit Francci3_3713 191 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 86740706 Nonpathogen - hypothetical protein Francci3_2003 2 None None None 86741126 Common - acyl-CoA dehydrogenase-like Francci3_2430 164 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 86741266 Common - hypothetical protein Francci3_2575 14 COG4995 COG4995, Uncharacterized protein conserved in bacteria Function unknown 86739751 Common - oligoribonuclease Francci3_1040 88 COG1949 Orn, Oligoribonuclease (3'->5' exoribonuclease) RNA processing and modification 86742349 Common - hypothetical protein Francci3_3668 24 None None None 86741649 Common - transposase IS200-like Francci3_2962 69 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742249 Common - transcriptional regulator, BadM/Rrf2 family Francci3_3568 169 COG1959 COG1959, Predicted transcriptional regulator Transcription 86740806 Common - GCN5-related N-acetyltransferase Francci3_2105 48 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 86742385 Common - Cobalamin adenosyltransferase Francci3_3704 130 COG2096 COG2096, Uncharacterized conserved protein Function unknown 86743026 Nonpathogen - hypothetical protein Francci3_4351 2 None None None 86743216 Common - Cobyrinic acid a,c-diamide synthase Francci3_4541 199 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 86739322 Common - ribosomal protein S4 Francci3_0609 237 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 86739388 Common - hypothetical protein Francci3_0675 7 None None None 86742565 Nonpathogen - hypothetical protein Francci3_3886 1 None None None 86742058 Common - Myo-inositol 2-dehydrogenase Francci3_3374 126 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 86741871 Common - Riboflavin synthase Francci3_3185 159 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 86739299 Common - ribosomal protein S19 Francci3_0586 236 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 86739114 Common - putative DNA-binding protein Francci3_0398 6 None None None 86741653 Nonpathogen - hypothetical protein Francci3_2967 1 None None None 86740504 Nonpathogen - hypothetical protein Francci3_1799 1 None None None 86739981 Common - Antibiotic biosynthesis monooxygenase Francci3_1274 4 None None None 86742509 Common - peptidase S1 and S6, chymotrypsin/Hap Francci3_3830 221 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 86740627 Common - FAD dependent oxidoreductase Francci3_1923 21 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 86738857 Nonpathogen - hypothetical protein Francci3_0134 1 None None None 86742290 Common - D-alanine--D-alanine ligase Francci3_3609 216 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 86743085 Common - aminoglycoside phosphotransferase Francci3_4410 5 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 86742817 Common - luciferase-like Francci3_4140 98 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 86742962 Nonpathogen - hypothetical protein Francci3_4287 1 None None None 86742633 Nonpathogen - hypothetical protein Francci3_3954 1 None None None 86739909 Nonpathogen - Excisionase/Xis, DNA-binding Francci3_1202 3 None None None 86742500 Common - Cytochrome-c oxidase Francci3_3821 162 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 86743058 Common - ATPase AAA-2 Francci3_4383 220 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 86741840 Nonpathogen - hypothetical protein Francci3_3154 1 None None None 86739144 Common - 3-dehydroquinate dehydratase Francci3_0428 169 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 86738985 Common recR recombination protein RecR Francci3_0268 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 86738839 Common - site-specific recombinase XerD-like Francci3_0116 37 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86741678 Common - amidohydrolase Francci3_2992 65 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 86739181 Common - Tetratricopeptide TPR_2 Francci3_0466 5 None None None 86741198 Common - acetyl-CoA acetyltransferase Francci3_2502 90 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 86742120 Common - transposase IS116/IS110/IS902 Francci3_3437 79 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742765 Common - putative replication initiation protein Francci3_4088 5 None None None 86740136 Nonpathogen - ABC-2 Francci3_1430 4 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 86738832 Nonpathogen - hypothetical protein Francci3_0109 1 None None None 86739668 Common - hypothetical protein Francci3_0955 6 COG2442 COG2442, Uncharacterized conserved protein Function unknown 86739374 Common - beta-lactamase Francci3_0661 79 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 86742357 Common - protein of unknown function DUF475 Francci3_3676 39 COG2899 COG2899, Uncharacterized protein conserved in bacteria Function unknown 86741032 Common - transcriptional modulator of MazE/toxin, MazF Francci3_2335 7 COG2337 MazF, Growth inhibitor Signal transduction mechanisms 86742844 Common - putative transposase Francci3_4167 46 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739988 Common - deoxyguanosinetriphosphate triphosphohydrolase-like protein Francci3_1281 161 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 86741501 Common - hypothetical protein Francci3_2814 6 None None None 86739664 Common - Peptidase C56, PfpI Francci3_0951 152 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 86740229 Nonpathogen - hypothetical protein Francci3_1524 1 None None None 86740968 Common - Dolichyl-phosphate beta-D-mannosyltransferase Francci3_2271 189 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86742438 Common - glycerophosphoryl diester phosphodiesterase Francci3_3758 109 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 86741563 Common - superoxide dismutase, copper/zinc binding Francci3_2876 4 COG2032 SodC, Cu/Zn superoxide dismutase Inorganic ion transport and metabolism 86740961 Common - Resolvase-like Francci3_2264 112 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 86740538 Nonpathogen - putative serine/threonine kinase anti-sigma factor Francci3_1833 4 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 86742814 Common - transcriptional regulator, TetR family Francci3_4137 4 None None None 86743204 Common - Myo-inositol-1-phosphate synthase Francci3_4529 57 COG1260 INO1, Myo-inositol-1-phosphate synthase Lipid metabolism 86739523 Nonpathogen - Resolvase helix-turn-helix region Francci3_0810 1 None None None 86740534 Common - hypothetical protein Francci3_1829 4 None None None 86739091 Common - cystathionine beta-synthase Francci3_0375 222 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 86740076 Common - DNA recombination protein, RuvA Francci3_1370 205 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 86740584 Nonpathogen - GCN5-related N-acetyltransferase Francci3_1879 2 COG0456 RimI, Acetyltransferases General function prediction only 86740449 Nonpathogen - hypothetical protein Francci3_1744 1 None None None 86743111 Common - serine/threonine protein kinase Francci3_4436 155 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86742794 Nonpathogen - hypothetical protein Francci3_4117 1 None None None 86742527 Common - glycosyl transferase, group 1 Francci3_3848 185 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86741594 Common - SpoOM Francci3_2907 17 COG4326 Spo0M, Sporulation control protein General function prediction only 86743010 Nonpathogen - hypothetical protein Francci3_4335 5 None None None 86742502 Common - hypothetical protein Francci3_3823 6 None None None 86743153 Common - nitrogenase cofactor biosynthesis protein NifB Francci3_4478 70 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 86740871 Common - GrpE protein Francci3_2172 119 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 86739579 Common - Mov34/MPN/PAD-1 Francci3_0866 38 COG1310 COG1310, Predicted metal-dependent protease of the PAD1/JAB1 superfamily General function prediction only 86740273 Nonpathogen - lipopolysaccharide biosynthesis Francci3_1568 1 COG3944 COG3944, Capsular polysaccharide biosynthesis protein Cell envelope biogenesis, outer membrane 86740164 Common - Small GTP-binding protein domain Francci3_1458 229 COG1160 COG1160, Predicted GTPases General function prediction only 86739626 Common - DSBA oxidoreductase Francci3_0913 58 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 86740211 Nonpathogen - hypothetical protein Francci3_1506 1 COG3339 COG3339, Uncharacterized conserved protein Function unknown 86740865 Common - Citrate lyase Francci3_2166 117 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 86739688 Common - NADH dehydrogenase Francci3_0975 173 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 86738733 Common - glycosyl transferase, group 1 Francci3_0010 177 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86740447 Nonpathogen - hypothetical protein Francci3_1742 4 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 86740922 Nonpathogen - transcriptional regulator, MarR family Francci3_2225 4 COG1846 MarR, Transcriptional regulators Transcription 86741191 Common - pyruvate decarboxylase Francci3_2495 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 86741938 Common - hypothetical protein Francci3_3252 56 COG2187 COG2187, Uncharacterized protein conserved in bacteria Function unknown 86740037 Common - 3'-5' exonuclease Francci3_1331 109 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 86739171 Common - glycosyl transferase, group 1 Francci3_0456 193 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86740354 Common - protoheme IX farnesyltransferase Francci3_1649 181 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 86739588 Common - Antibiotic biosynthesis monooxygenase Francci3_0875 15 COG1359 COG1359, Uncharacterized conserved protein Function unknown 86739818 Common - transposase, IS4 Francci3_1109 56 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740069 Common - lipid A biosynthesis lauroyl acyltransferase Francci3_1363 12 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 86743012 Common - Prevent-host-death protein Francci3_4337 19 None None None 86741621 Common - monooxygenase, FAD-binding Francci3_2934 82 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 86740991 Common - monooxygenase, FAD-binding Francci3_2294 19 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 86739646 Common - hypothetical protein Francci3_0933 2 None None None 86740438 Nonpathogen - hypothetical protein Francci3_1733 1 None None None 86741868 Common infC translation initiation factor IF-3 Francci3_3182 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 86742468 Common - ABC-1 Francci3_3788 184 COG0661 AarF, Predicted unusual protein kinase General function prediction only 86741639 Common - serine/threonine protein kinase Francci3_2952 65 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86742183 Common - putative PAS/PAC sensor protein Francci3_3501 95 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 86741799 Common - response regulator receiver protein Francci3_3113 12 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 86740663 Common - transposase IS116/IS110/IS902 Francci3_1959 47 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741826 Common - hypothetical protein Francci3_3140 19 None None None 86739229 Common ubiA prenyltransferase Francci3_0516 122 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 86740897 Common - Epoxide hydrolase-like Francci3_2199 38 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86741665 Common - regulatory protein GntR, HTH Francci3_2979 104 COG2186 FadR, Transcriptional regulators Transcription 86741068 Common - hypothetical protein Francci3_2372 13 None None None 86740252 Common - Alcohol dehydrogenase, zinc-binding Francci3_1547 154 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 86739112 Nonpathogen - hypothetical protein Francci3_0396 1 None None None 86742482 Common - molybdopterin biosynthesis-like protein MoeZ Francci3_3803 226 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 86740943 Common - ATP-dependent transcriptional regulator, MalT-like, LuxR family Francci3_2246 61 COG2909 MalT, ATP-dependent transcriptional regulator Transcription 86740451 Common - hypothetical protein Francci3_1746 19 None None None 86740751 Nonpathogen - hypothetical protein Francci3_2048 1 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86742240 Common - phosphoesterase, RecJ-like Francci3_3559 80 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 86740431 Common - transposase IS3/IS911 Francci3_1726 61 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 86743025 Common - protein of unknown function DUF224, cysteine-rich region Francci3_4350 109 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 86741548 Common - Enoyl-CoA hydratase/isomerase Francci3_2861 177 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 86740295 Common - ABC transporter related Francci3_1590 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 86741410 Common - Recombinase Francci3_2721 79 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 86739651 Common - FAD dependent oxidoreductase Francci3_0938 149 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 86738850 Common - transcriptional regulator, XRE family Francci3_0127 10 COG1396 HipB, Predicted transcriptional regulators Transcription 86742174 Common - Polyphosphate-glucose phosphotransferase Francci3_3492 29 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 86742486 Common - hypothetical protein Francci3_3807 17 None None None 86739552 Common - Allantoinase Francci3_0839 181 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 86738809 Common - transcriptional regulator, MarR family Francci3_0086 28 COG1846 MarR, Transcriptional regulators Transcription 86742108 Nonpathogen - hypothetical protein Francci3_3425 1 None None None 86739494 Common - type II secretion system protein Francci3_0781 23 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 86742335 Common - hypothetical protein Francci3_3654 6 COG0478 COG0478, RIO-like serine/threonine protein kinase fused to N-terminal HTH domain Signal transduction mechanisms 86740763 Common - putative IS630 family transposase Francci3_2061 45 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740607 Common hemH ferrochelatase Francci3_1902 73 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 86739030 Common - amidohydrolase 2 Francci3_0314 7 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 86738874 Common - transposase, IS4 Francci3_0151 66 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86743088 Common - hypothetical protein Francci3_4413 9 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 86740096 Nonpathogen - hypothetical protein Francci3_1390 1 None None None 86739097 Common - inner-membrane translocator Francci3_0381 14 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 86738992 Common - WD-40 repeat protein Francci3_0276 49 COG2319 COG2319, FOG: WD40 repeat General function prediction only 86742909 Common - protein of unknown function DUF181 Francci3_4234 13 COG1944 COG1944, Uncharacterized conserved protein Function unknown 86739422 Common - UDP-glucose 6-dehydrogenase Francci3_0709 206 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 86739914 Common clpX ATP-dependent protease ATP-binding subunit Francci3_1207 226 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 86739354 Common - protein of unknown function, ATP binding Francci3_0641 31 COG2229 COG2229, Predicted GTPase General function prediction only 86742900 Common - putative transposase Francci3_4225 42 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740813 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding Francci3_2112 12 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 86741535 Nonpathogen - Antibiotic biosynthesis monooxygenase Francci3_2848 2 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 86740423 Nonpathogen - hypothetical protein Francci3_1718 1 None None None 86740529 Nonpathogen - hypothetical protein Francci3_1824 3 None None None 86740887 Common - sulfatase Francci3_2189 75 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 86739564 Nonpathogen - hypothetical protein Francci3_0851 1 None None None 86740919 Common - HNH endonuclease Francci3_2222 7 COG1403 McrA, Restriction endonuclease Defense mechanisms 86741442 Common - Rhodanese-like Francci3_2753 22 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 86741920 Common - MMPL Francci3_3234 66 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 86738966 Common - ABC transporter related Francci3_0249 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 86740892 Common - transposase Francci3_2194 17 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741551 Nonpathogen - hypothetical protein Francci3_2864 1 None None None 86742220 Common - CDP-alcohol phosphatidyltransferase Francci3_3539 195 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 86742191 Common - Peptidoglycan-binding LysM Francci3_3509 5 COG1388 LytE, FOG: LysM repeat Cell envelope biogenesis, outer membrane 86739532 Common - Squalene/phytoene synthase Francci3_0819 88 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 86739266 Nonpathogen - CG32656 gene product from transcript CG32656-RA Francci3_0553 2 None None None 86739479 Common - GCN5-related N-acetyltransferase Francci3_0766 103 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 86742985 Common - Inorganic diphosphatase Francci3_4310 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 86743175 Common - 4Fe-4S ferredoxin, iron-sulfur binding Francci3_4500 31 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 86741396 Nonpathogen - hypothetical protein Francci3_2706 2 None None None 86740644 Common - peptidase M52, hydrogen uptake protein Francci3_1940 46 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 86742141 Common - hypothetical protein Francci3_3458 13 COG4124 ManB, Beta-mannanase Carbohydrate transport and metabolism 86742272 Common - tRNA (guanine-N1)-methyltransferase Francci3_3591 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 86743162 Common - nitrogenase molybdenum-iron protein alpha chain Francci3_4487 51 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 86742279 Common - acylphosphatase Francci3_3598 24 COG1254 AcyP, Acylphosphatases Energy production and conversion 86742877 Common - hypothetical protein Francci3_4200 4 None None None 86741233 Common - transposase, IS4 Francci3_2540 56 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742019 Nonpathogen - hypothetical protein Francci3_3333 2 None None None 86738811 Common - 2',5' RNA ligase Francci3_0088 6 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 86740205 Nonpathogen - amidinotransferase Francci3_1500 1 COG2235 ArcA, Arginine deiminase Amino acid transport and metabolism 86738980 Common - stress protein Francci3_0263 29 COG2310 TerZ, Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 Signal transduction mechanisms 86739196 Common - HAD-superfamily subfamily IB, PSPase-like Francci3_0481 83 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 86740406 Nonpathogen - hypothetical protein Francci3_1701 1 None None None 86739804 Nonpathogen - hypothetical protein Francci3_1094 1 None None None 86741962 Common - acyl-CoA dehydrogenase-like Francci3_3276 149 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 86741367 Common - helicase-like Francci3_2676 26 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 86741480 Common - hypothetical protein Francci3_2793 7 None None None 86742552 Nonpathogen - hypothetical protein Francci3_3873 1 None None None 86739009 Common - hypothetical protein Francci3_0293 12 COG4124 ManB, Beta-mannanase Carbohydrate transport and metabolism 86742158 Common - UDP-3-O-(3-hydroxymyristoyl)-like Francci3_3476 72 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 86742827 Nonpathogen - protein of unknown function DUF1205 Francci3_4150 1 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 86741702 Common - tryptophan synthase subunit beta Francci3_3016 224 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 86741591 Common - protein of unknown function DUF124 Francci3_2904 40 COG2310 TerZ, Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 Signal transduction mechanisms 86740672 Nonpathogen - hypothetical protein Francci3_1969 1 None None None 86740771 Common - 3-dehydroquinate synthase Francci3_2069 28 COG1465 COG1465, Predicted alternative 3-dehydroquinate synthase Amino acid transport and metabolism 86740384 Nonpathogen - hypothetical protein Francci3_1679 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 86739086 Nonpathogen - hypothetical protein Francci3_0370 1 None None None 86741497 Common - FAD-binding 9, siderophore-interacting Francci3_2810 63 COG2375 ViuB, Siderophore-interacting protein Inorganic ion transport and metabolism 86740837 Common - serine/threonine protein kinase Francci3_2136 140 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86741074 Nonpathogen - hypothetical protein Francci3_2378 1 None None None 86741465 Common - putative resolvase Francci3_2776 8 COG2452 COG2452, Predicted site-specific integrase-resolvase DNA replication, recombination, and repair 86739679 Nonpathogen - hypothetical protein Francci3_0966 3 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 86742935 Common - HhH-GPD Francci3_4260 188 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 86741434 Common - protein of unknown function DUF470 Francci3_2745 43 COG2898 COG2898, Uncharacterized conserved protein Function unknown 86741558 Common - major facilitator superfamily MFS_1 Francci3_2871 163 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86739002 Nonpathogen - hypothetical protein Francci3_0286 2 None None None 86741585 Nonpathogen - hypothetical protein Francci3_2898 1 None None None 86742231 Common - UDP-glucose 4-epimerase Francci3_3550 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 86741246 Common - reverse transcriptase Francci3_2554 19 None None None 86741376 Common - Rieske (2Fe-2S) protein Francci3_2686 70 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 86740742 Nonpathogen - hypothetical protein Francci3_2039 1 None None None 86739812 Nonpathogen - hypothetical protein Francci3_1103 1 None None None 86742234 Common - dihydrodipicolinate reductase Francci3_3553 211 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 86738861 Common - cell divisionFtsK/SpoIIIE Francci3_0138 175 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 86741326 Common - ABC transporter related Francci3_2635 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 86741478 Common - Silent information regulator protein Sir2 Francci3_2791 146 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 86742600 Common - protein of unknown function DUF501 Francci3_3921 26 COG1507 COG1507, Uncharacterized conserved protein Function unknown 86739520 Nonpathogen - transcriptional regulator, XRE family Francci3_0807 3 COG1395 COG1395, Predicted transcriptional regulator Transcription 86741054 Common - Zeta toxin Francci3_2358 10 None None None 86741998 Nonpathogen - hypothetical protein Francci3_3312 3 None None None 86739170 Common - hypothetical protein Francci3_0455 10 None None None 86741081 Common - Ham1-like protein Francci3_2385 236 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 86740545 Common - protein of unknown function DUF574 Francci3_1840 12 None None None 86743075 Common - helicase-like Francci3_4400 62 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 86739595 Common - protein of unknown function DUF955 Francci3_0882 57 COG2856 COG2856, Predicted Zn peptidase Amino acid transport and metabolism 86742072 Nonpathogen - hypothetical protein Francci3_3389 1 None None None 86742578 Common - hypothetical protein Francci3_3899 7 None None None 86741685 Common - protein of unknown function DUF21 Francci3_2999 219 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 86742292 Common - putative transcriptional regulator, AsnC family Francci3_3611 37 COG1522 Lrp, Transcriptional regulators Transcription 86740611 Common - glycosyl transferase, group 1 Francci3_1906 74 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86742477 Common - Endonuclease/exonuclease/phosphatase Francci3_3798 16 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 86739308 Common - ribosomal protein S14 Francci3_0595 161 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 86743210 Nonpathogen - hypothetical protein Francci3_4535 1 None None None 86742136 Common - transcriptional regulator, MerR family Francci3_3453 118 COG0789 SoxR, Predicted transcriptional regulators Transcription 86740542 Nonpathogen - hypothetical protein Francci3_1837 1 None None None 86738868 Common - transcriptional regulator, SARP family Francci3_0145 10 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 86742991 Common hisG ATP phosphoribosyltransferase Francci3_4316 210 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 86742161 Common - RNA-binding S4 Francci3_3479 43 COG2501 COG2501, Uncharacterized conserved protein Function unknown 86739152 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Francci3_0436 16 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 86742012 Nonpathogen - hypothetical protein Francci3_3326 1 None None None 86742383 Nonpathogen - hypothetical protein Francci3_3702 1 None None None 86739395 Common - serine/threonine protein kinase Francci3_0682 139 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86739850 Common - cell divisionFtsK/SpoIIIE Francci3_1142 9 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 86740330 Common - Dephospho-CoA kinase Francci3_1625 203 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 86739105 Common - hypothetical protein Francci3_0389 19 COG4683 COG4683, Uncharacterized protein conserved in bacteria Function unknown 86742763 Common - hypothetical protein Francci3_4086 11 None None None 86740729 Common - hypothetical protein Francci3_2026 12 COG5514 COG5514, Uncharacterized conserved protein Function unknown 86738884 Common - hypothetical protein Francci3_0163 59 COG3391 COG3391, Uncharacterized conserved protein Function unknown 86739162 Common - thioredoxin-related Francci3_0447 19 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 86739216 Common - putative methyltransferase Francci3_0502 116 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86740903 Nonpathogen - hypothetical protein Francci3_2205 2 None None None 86741487 Common - hypothetical protein Francci3_2800 7 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 86742856 Nonpathogen - hypothetical protein Francci3_4179 1 None None None 86742614 Nonpathogen - hypothetical protein Francci3_3935 4 None None None 86742403 Common - transcription termination factor Rho Francci3_3722 215 COG1158 Rho, Transcription termination factor Transcription 86739578 Nonpathogen - hypothetical protein Francci3_0865 1 None None None 86742778 Common - beta-ketoacyl synthase Francci3_4101 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86739288 Common - pseudouridine synthase Francci3_0575 193 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 86740948 Common - beta-lactamase-like Francci3_2251 78 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 86738787 Common - aminotransferase AlaT Francci3_0064 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 86739761 Common - hypothetical protein Francci3_1050 9 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 86742703 Nonpathogen - hypothetical protein Francci3_4024 10 None None None 86742497 Common - stress protein Francci3_3818 28 COG2310 TerZ, Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 Signal transduction mechanisms 86739077 Common - TRAP-type uncharacterized transport system periplasmic component-like Francci3_0361 27 COG2358 Imp, TRAP-type uncharacterized transport system, periplasmic component General function prediction only 86742872 Nonpathogen - hypothetical protein Francci3_4195 1 None None None 86739079 Nonpathogen - hypothetical protein Francci3_0363 1 None None None 86739746 Nonpathogen - hypothetical protein Francci3_1035 1 None None None 86740296 Common - binding-protein-dependent transport systems inner membrane component Francci3_1591 148 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 86742001 Common - Lantibiotic dehydratase-like Francci3_3315 7 None None None 86740276 Common - hypothetical protein Francci3_1571 14 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86743104 Common - phosphoribosylformylglycinamidine synthetase PurS Francci3_4429 77 COG1828 PurS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component Nucleotide transport and metabolism 86739019 Common - two component transcriptional regulator, LuxR family Francci3_0303 215 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86740387 Common - SpoVT/AbrB-like Francci3_1682 20 COG4456 VagC, Virulence-associated protein and related proteins Function unknown 86740904 Common - hypothetical protein Francci3_2206 20 None None None 86738921 Nonpathogen - hypothetical protein Francci3_0202 1 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 86740263 Common - cell envelope-related transcriptional attenuator Francci3_1558 61 COG1316 LytR, Transcriptional regulator Transcription 86741974 Common - two component transcriptional regulator, winged helix family Francci3_3288 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86739297 Common rplW 50S ribosomal protein L23 Francci3_0584 217 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 86740989 Common - transcriptional regulator, XRE family Francci3_2292 10 None None None 86741333 Common - cysteinyl-tRNA synthetase Francci3_2642 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86738956 Nonpathogen - hypothetical protein Francci3_0238 1 None None None 86739413 Common - carboxyl transferase Francci3_0700 205 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 86741545 Common - protein of unknown function DUF742 Francci3_2858 9 None None None 86738736 Common - hypothetical protein Francci3_0013 15 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 86742036 Common - phage integrase Francci3_3350 31 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 86742085 Common - YbaK/prolyl-tRNA synthetase-like protein Francci3_3402 71 COG2606 EbsC, Uncharacterized conserved protein Function unknown 86739932 Common - putative exonuclease Francci3_1225 94 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 86740143 Common - protein of unknown function DUF164 Francci3_1437 25 COG1579 COG1579, Zn-ribbon protein, possibly nucleic acid-binding General function prediction only 86740979 Common - major facilitator superfamily MFS_1 Francci3_2282 26 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86742422 Common - aminotransferase, class I and II Francci3_3742 185 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 86740592 Common - NADPH-dependent FMN reductase Francci3_1887 100 COG0431 COG0431, Predicted flavoprotein General function prediction only 86741715 Common - two component transcriptional regulator, winged helix family Francci3_3029 210 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86739900 Common - acyl-CoA dehydrogenase-like Francci3_1193 155 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 86738824 Nonpathogen - hypothetical protein Francci3_0101 10 None None None 86742051 Common - hypothetical protein Francci3_3367 2 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 86739649 Common - 6-phosphogluconate dehydrogenase-like protein Francci3_0936 177 COG1023 Gnd, Predicted 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 86739602 Common - transcriptional regulator, XRE family Francci3_0889 56 COG1396 HipB, Predicted transcriptional regulators Transcription 86738943 Common - UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase-like Francci3_0225 21 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 86739319 Common rpmJ 50S ribosomal protein L36 Francci3_0606 128 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 86739175 Common - transcriptional regulator, XRE family Francci3_0460 18 COG1396 HipB, Predicted transcriptional regulators Transcription 86739055 Nonpathogen - heat shock protein DnaJ-like Francci3_0339 3 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 86740772 Common - Fructose-bisphosphate aldolase Francci3_2070 77 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 86739081 Common - Thioesterase Francci3_0365 64 COG3319 COG3319, Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases Secondary metabolites biosynthesis, transport, and catabolism 86739341 Common - ribosomal-protein-alanine acetyltransferase Francci3_0628 40 COG0456 RimI, Acetyltransferases General function prediction only 86742202 Common - extracellular solute-binding protein, family 3 Francci3_3520 171 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 86739522 Common - hypothetical protein Francci3_0809 8 COG4734 ArdA, Antirestriction protein General function prediction only 86740587 Common - transposase Francci3_1882 31 None None None 86742287 Common - conserved hypothetical protein 95 Francci3_3606 210 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 86742040 Common - Epoxide hydrolase-like Francci3_3356 60 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86739794 Common - hypothetical protein Francci3_1083 10 None None None 86742374 Common - hypothetical protein Francci3_3693 7 COG3339 COG3339, Uncharacterized conserved protein Function unknown 86740313 Common - cytochrome P450 Francci3_1608 72 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 86741724 Common - transcriptional regulator, LuxR family Francci3_3038 49 COG3899 COG3899, Predicted ATPase General function prediction only 86740198 Nonpathogen - hypothetical protein Francci3_1493 1 COG1724 COG1724, Predicted periplasmic or secreted lipoprotein Cell motility and secretion 86739783 Common - (NiFe) hydrogenase maturation protein HypF Francci3_1072 109 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 86739408 Common - hypothetical protein Francci3_0695 16 None None None 86740656 Nonpathogen - hypothetical protein Francci3_1952 1 None None None 86742781 Nonpathogen - aromatic-ring-hydroxylating dioxygenase, beta subunit Francci3_4104 2 None None None 86739977 Nonpathogen - hypothetical protein Francci3_1270 4 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 86739590 Common - DNA integration/recombination/invertion protein Francci3_0877 3 None None None 86739223 Common - putative secreted protein Francci3_0510 163 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 86739256 Common - NADH-quinone oxidoreductase, F subunit Francci3_0543 168 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 86741730 Nonpathogen - hypothetical protein Francci3_3044 2 None None None 86742531 Common - glycosyl transferase, family 2 Francci3_3852 192 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86742123 Common - sodium/hydrogen exchanger Francci3_3440 101 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 86739772 Nonpathogen - hypothetical protein Francci3_1061 2 None None None 86739529 Common - MMPL Francci3_0816 38 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 86739847 Nonpathogen - transcriptional regulator, XRE family Francci3_1139 2 None None None 86742023 Nonpathogen - hypothetical protein Francci3_3337 2 None None None 86742626 Common - glycosyltransferases-like Francci3_3947 76 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 86740361 Common - transcriptional regulator, XRE family Francci3_1656 7 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 86741801 Common - putative integral membrane protein Francci3_3115 17 None None None 86741717 Common - O-methyltransferase, family 3 Francci3_3031 98 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 86740757 Nonpathogen - hypothetical protein Francci3_2054 1 None None None 86738879 Common - hypothetical protein Francci3_0158 32 COG4995 COG4995, Uncharacterized protein conserved in bacteria Function unknown 86743033 Common - membrane-flanked domain Francci3_4358 28 COG3428 COG3428, Predicted membrane protein Function unknown 86741295 Common cobD cobalamin biosynthesis protein Francci3_2604 98 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 86741117 Common - diguanylate phosphodiesterase (EAL domain) with GAF sensor Francci3_2421 154 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 86740718 Common - transcriptional regulator, MarR family Francci3_2015 27 COG1846 MarR, Transcriptional regulators Transcription 86740511 Common - AMP-dependent synthetase and ligase Francci3_1806 145 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86738765 Nonpathogen - hypothetical protein Francci3_0042 1 None None None 86739769 Common - protein of unknown function DUF343 Francci3_1058 8 COG2835 COG2835, Uncharacterized conserved protein Function unknown 86742846 Common - hypothetical protein Francci3_4169 21 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741601 Common - 3-demethylubiquinone-9 3-methyltransferase Francci3_2914 66 COG3865 COG3865, Uncharacterized protein conserved in bacteria Function unknown 86740493 Nonpathogen - hypothetical protein Francci3_1788 3 None None None 86740460 Common - 6-pyruvoyl tetrahydropterin synthase and hypothetical protein Francci3_1755 89 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 86738804 Common - citrate synthase 2 Francci3_0081 188 COG0372 GltA, Citrate synthase Energy production and conversion 86739822 Common - Methyltransferase type 11 Francci3_1113 93 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86741379 Common - pyruvate phosphate dikinase, PEP/pyruvate-binding Francci3_2689 170 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 86742969 Common - protein of unknown function DUF1469 Francci3_4294 8 None None None 86740747 Nonpathogen - thioesterase superfamily Francci3_2044 1 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 86739739 Nonpathogen - hypothetical protein Francci3_1027 1 None None None 86740647 Common - nitrogen-fixing NifU-like Francci3_1943 6 COG0694 COG0694, Thioredoxin-like proteins and domains Posttranslational modification, protein turnover, chaperones 86740046 Common - inositol monophosphatase Francci3_1340 117 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 86742296 Nonpathogen - hypothetical protein Francci3_3615 1 None None None 86742096 Common - protein serine/threonine phosphatases Francci3_3413 15 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 86739427 Nonpathogen - hypothetical protein Francci3_0714 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 86742435 Common - sigma 28 subunit Francci3_3755 216 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 86739990 Common - sigma 38 Francci3_1283 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 86739741 Nonpathogen - hypothetical protein Francci3_1029 1 None None None 86743038 Common - putative integral membrane protein Francci3_4363 97 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 86738847 Common - AAA ATPase Francci3_0124 146 COG1223 COG1223, Predicted ATPase (AAA+ superfamily) General function prediction only 86740984 Common - amidohydrolase 2 Francci3_2287 30 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 86740249 Common - Alcohol dehydrogenase GroES-like Francci3_1544 36 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 86742735 Common - IucA/IucC Francci3_4056 39 COG4264 RhbC, Siderophore synthetase component Secondary metabolites biosynthesis, transport, and catabolism 86740570 Nonpathogen - hypothetical protein Francci3_1865 1 None None None 86741616 Common - 2-nitropropane dioxygenase, NPD Francci3_2929 21 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 86742075 Common - Twin-arginine translocation pathway signal Francci3_3392 3 None None None 86742618 Nonpathogen - hypothetical protein Francci3_3939 1 None None None 86741746 Nonpathogen - hypothetical protein Francci3_3060 3 None None None 86740618 Common - OmpA/MotB Francci3_1913 109 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 86742611 Common - 4-diphosphocytidyl-2C-methyl-D-erythritol synthase Francci3_3932 154 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 86740219 Nonpathogen - hypothetical protein Francci3_1514 1 None None None 86743168 Common - molybdenum-pterin binding domain Francci3_4493 72 COG4148 ModC, ABC-type molybdate transport system, ATPase component Inorganic ion transport and metabolism 86740208 Common - hypothetical protein Francci3_1503 4 None None None 86740711 Common - transcriptional regulator, GntR family Francci3_2008 46 COG1802 GntR, Transcriptional regulators Transcription 86740187 Common - transcription factor WhiB Francci3_1482 6 None None None 86738821 Common - hypothetical protein Francci3_0098 6 None None None 86741541 Nonpathogen - phosphopantetheine-binding Francci3_2854 1 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86741402 Common - transposase, IS4 Francci3_2712 28 None None None 86742311 Common - putative signal-transduction protein with CBS domains Francci3_3630 106 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 86739559 Common - tRNA/rRNA methyltransferase Francci3_0846 55 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 86740061 Common - isochorismatase hydrolase Francci3_1355 96 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 86741858 Common - acetylornithine and succinylornithine aminotransferases Francci3_3172 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 86742463 Common - PDZ/DHR/GLGF Francci3_3783 30 COG3480 SdrC, Predicted secreted protein containing a PDZ domain Signal transduction mechanisms 86742517 Common - hypothetical protein Francci3_3838 7 None None None 86738904 Common - aromatic amino acid beta-eliminating lyase/threonine aldolase Francci3_0183 74 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 86739469 Common - hypothetical protein Francci3_0756 23 COG1300 SpoIIM, Uncharacterized membrane protein Function unknown 86742807 Nonpathogen - hypothetical protein Francci3_4130 1 COG1665 COG1665, Uncharacterized protein conserved in archaea Function unknown 86742332 Common - transcriptional regulator, MarR family Francci3_3651 49 COG1846 MarR, Transcriptional regulators Transcription 86742388 Common - F0F1 ATP synthase subunit beta Francci3_3707 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 86739460 Common - glycosyltransferases-like Francci3_0747 13 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 86740502 Common - ribulose-phosphate 3-epimerase Francci3_1797 205 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 86742551 Common - protein of unknown function DUF195 Francci3_3872 135 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 86742899 Nonpathogen - hypothetical protein Francci3_4224 1 None None None 86741705 Nonpathogen - hypothetical protein Francci3_3019 1 None None None 86740481 Common - transposase, IS4 Francci3_1776 28 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86740003 Nonpathogen - Methyltransferase FkbM Francci3_1297 9 None None None 86740267 Common - glycosyl transferase, group 1 Francci3_1562 58 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86741165 Nonpathogen - hypothetical protein Francci3_2469 2 None None None 86739610 Common - Radical SAM Francci3_0897 115 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 86742061 Common - Protein of unknown function UPF0011 Francci3_3377 210 COG0313 COG0313, Predicted methyltransferases General function prediction only 86739647 Common - ATPase-like Francci3_0934 20 COG0433 COG0433, Predicted ATPase General function prediction only 86742540 Common - flavin reductase-like, FMN-binding Francci3_3861 107 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 86742752 Nonpathogen - hypothetical protein Francci3_4075 3 None None None 86738794 Nonpathogen - hypothetical protein Francci3_0071 1 None None None 86741249 Common - putative 4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme Francci3_2558 3 None None None 86743015 Common - putative ABC transporter membrane protein Francci3_4340 10 None None None 86739857 Common - globin Francci3_1149 67 COG2346 COG2346, Truncated hemoglobins General function prediction only 86741619 Nonpathogen - hypothetical protein Francci3_2932 1 None None None 86742643 Common ksgA dimethyladenosine transferase Francci3_3964 199 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 86740629 Common - hypothetical protein Francci3_1925 12 None None None 86739401 Common - deoxyribose-phosphate aldolase Francci3_0688 135 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 86739786 Common - peptidase M52, hydrogen uptake protein Francci3_1075 60 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 86739292 Common - elongation factor G Francci3_0579 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 86742010 Nonpathogen - hypothetical protein Francci3_3324 3 None None None 86742411 Common - RNA-directed DNA polymerase Francci3_3730 86 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 86742053 Common - aminotransferase class-III Francci3_3369 227 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 86741792 Common - Rieske (2Fe-2S) protein Francci3_3106 34 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 86740620 Common - hypothetical protein Francci3_1915 2 None None None 86740768 Common - hypothetical protein Francci3_2066 5 COG0439 AccC, Biotin carboxylase Lipid metabolism 86739241 Common - uroporphyrin-III C-methyltransferase Francci3_0528 201 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 86742257 Common - Poly(3-hydroxybutyrate) depolymerase-like Francci3_3576 35 COG3509 LpqC, Poly(3-hydroxybutyrate) depolymerase Secondary metabolites biosynthesis, transport, and catabolism 86740980 Common - transcriptional regulator, TetR family Francci3_2283 31 COG1309 AcrR, Transcriptional regulator Transcription 86741883 Common - orotidine 5'-phosphate decarboxylase Francci3_3197 150 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 86740689 Nonpathogen - hypothetical protein Francci3_1986 2 None None None 86739194 Common - NAD-dependent epimerase/dehydratase Francci3_0479 81 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 86742003 Nonpathogen - hypothetical protein Francci3_3317 1 None None None 86741676 Nonpathogen - hypothetical protein Francci3_2990 3 COG2267 PldB, Lysophospholipase Lipid metabolism 86741926 Common - transposase IS116/IS110/IS902 Francci3_3240 28 None None None 86740736 Common - Lantibiotic dehydratase-like Francci3_2033 8 None None None 86739854 Nonpathogen - hypothetical protein Francci3_1146 4 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 86742343 Common - Enoyl-CoA hydratase/isomerase Francci3_3662 175 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 86740569 Common - transposase IS66 Francci3_1864 54 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741514 Common - Extracellular ligand-binding receptor Francci3_2827 66 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 86742399 Common - Sua5/YciO/YrdC/YwlC Francci3_3718 239 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 86740453 Common - GTP cyclohydrolase I Francci3_1748 176 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 86740792 Nonpathogen - acyl carrier protein Francci3_2091 2 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86742957 Common - Endoribonuclease L-PSP Francci3_4282 93 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 86741525 Common - binding-protein-dependent transport systems inner membrane component Francci3_2838 144 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 86742767 Common - Twin-arginine translocation pathway signal Francci3_4090 7 None None None 86739947 Common - Poly(3-hydroxybutyrate) depolymerase-like Francci3_1240 22 COG3509 LpqC, Poly(3-hydroxybutyrate) depolymerase Secondary metabolites biosynthesis, transport, and catabolism 86741894 Common - Shikimate kinase Francci3_3208 140 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 86742017 Common - hypothetical protein Francci3_3331 7 None None None 86742535 Common dapD 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase Francci3_3856 138 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 86740258 Nonpathogen - hypothetical protein Francci3_1553 1 None None None 86743143 Nonpathogen - hypothetical protein Francci3_4468 1 None None None 86740551 Nonpathogen - hypothetical protein Francci3_1846 1 None None None 86739205 Common - Heavy metal translocating P-type ATPase Francci3_0490 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 86739383 Common - protein of unknown function UPF0150 Francci3_0670 15 COG1598 COG1598, Uncharacterized conserved protein Function unknown 86742181 Common - hypothetical protein Francci3_3499 7 COG1412 COG1412, Uncharacterized proteins of PilT N-term./Vapc superfamily General function prediction only 86742470 Nonpathogen - hypothetical protein Francci3_3791 1 None None None 86741202 Common - Hydantoinase B/oxoprolinase Francci3_2506 92 COG0146 HyuB, N-methylhydantoinase B/acetone carboxylase, alpha subunit Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86741349 Common - FAD linked oxidase-like Francci3_2658 182 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 86740649 Common - (NiFe) hydrogenase maturation protein HypF Francci3_1945 109 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 86742920 Common - Transglycosylase-like Francci3_4245 5 None None None 86740352 Common - glucose-6-phosphate 1-dehydrogenase Francci3_1647 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 86741596 Common - peptidase S9, prolyl oligopeptidase active site region Francci3_2909 131 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 86740791 Common - 3-oxoacyl-(acyl carrier protein) synthase III Francci3_2090 214 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 86740810 Nonpathogen - hypothetical protein Francci3_2109 1 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 86742950 Common - metallophosphoesterase Francci3_4275 60 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 86740750 Nonpathogen - hypothetical protein Francci3_2047 1 None None None 86742066 Nonpathogen - ribosomal RNA methyltransferase Francci3_3382 3 None None None 86740086 Common - type III restriction enzyme, res subunit Francci3_1380 26 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 86743114 Nonpathogen - hypothetical protein Francci3_4439 1 None None None 86741039 Nonpathogen - hypothetical protein Francci3_2343 1 None None None 86742737 Common - IucA/IucC Francci3_4058 47 COG4264 RhbC, Siderophore synthetase component Secondary metabolites biosynthesis, transport, and catabolism 86739864 Common - periplasmic sensor signal transduction histidine kinase Francci3_1156 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 86741424 Common - HipA protein Francci3_2735 64 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 86742605 Common - transcription-repair coupling factor Francci3_3926 225 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 86738981 Common - Alcohol dehydrogenase GroES-like Francci3_0264 200 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 86743054 Common - pantothenate kinase Francci3_4379 130 COG1521 COG1521, Putative transcriptional regulator, homolog of Bvg accessory factor Transcription 86740691 Common - peptidase S1 and S6, chymotrypsin/Hap Francci3_1988 221 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 86739611 Common - hypothetical protein Francci3_0898 3 None None None 86739509 Common - uroporphyrin-III C-methyltransferase Francci3_0796 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 86740702 Common - hypothetical protein Francci3_1999 14 COG5424 COG5424, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C Coenzyme metabolism 86740913 Nonpathogen - hypothetical protein Francci3_2215 1 None None None 86743132 Common - Glycerate kinase Francci3_4457 81 COG1929 COG1929, Glycerate kinase Carbohydrate transport and metabolism 86739302 Common rplP 50S ribosomal protein L16 Francci3_0589 217 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 86742105 Common - Twin-arginine translocation pathway signal Francci3_3422 13 COG5563 COG5563, Predicted integral membrane proteins containing uncharacterized repeats Function unknown 86740786 Nonpathogen - hypothetical protein Francci3_2085 3 None None None 86741113 Common - binding-protein-dependent transport systems inner membrane component Francci3_2417 211 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 86740286 Common - glycosyl transferase, family 2 Francci3_1581 13 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86740970 Common - Amidohydrolase 3 Francci3_2273 86 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 86741588 Common - hypothetical protein Francci3_2901 30 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 86739779 Nonpathogen - hypothetical protein Francci3_1068 2 None None None 86742418 Common - luciferase-like Francci3_3738 84 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 86740698 Common - hypothetical protein Francci3_1995 16 COG4341 COG4341, Predicted HD phosphohydrolase General function prediction only 86739726 Nonpathogen - hypothetical protein Francci3_1014 1 None None None 86739907 Nonpathogen - Excisionase/Xis, DNA-binding Francci3_1200 1 None None None 86739334 Common - protein of unknown function UPF0031 Francci3_0621 86 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 86741941 Common - L-carnitine dehydratase/bile acid-inducible protein F Francci3_3255 112 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 86739251 Common - NADH dehydrogenase subunit A Francci3_0538 161 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 86742449 Common - hydrolase of the alpha/beta-hydrolase fold-like Francci3_3769 33 COG3571 COG3571, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 86740251 Common - GCN5-related N-acetyltransferase Francci3_1546 15 COG3393 COG3393, Predicted acetyltransferase General function prediction only 86740835 Common - hypothetical protein Francci3_2134 16 None None None 86739035 Common - glycosyl transferase, family 39 Francci3_0319 17 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 86739312 Common rpsE 30S ribosomal protein S5 Francci3_0599 247 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 86742592 Nonpathogen - hypothetical protein Francci3_3913 1 None None None 86739472 Common - AAA_3 ATPase associated with various cellular activities Francci3_0759 171 COG0714 COG0714, MoxR-like ATPases General function prediction only 86741832 Common - NAD+ synthetase Francci3_3146 214 COG0171 NadE, NAD synthase Coenzyme metabolism 86741710 Common hisH imidazole glycerol phosphate synthase subunit HisH Francci3_3024 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 86741493 Nonpathogen - hypothetical protein Francci3_2806 1 None None None 86742276 Common - signal recognition particle protein Francci3_3595 246 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 86739141 Common - sulphate transporter Francci3_0425 124 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 86739502 Nonpathogen - hypothetical protein Francci3_0789 1 None None None 86743019 Common - glutamine amidotransferase, class-II Francci3_4344 81 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 86741211 Common - protein of unknown function DUF59 Francci3_2515 18 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 86741574 Common - hypothetical protein Francci3_2887 3 None None None 86742363 Nonpathogen - hypothetical protein Francci3_3682 1 None None None 86740319 Common - protein of unknown function DUF574 Francci3_1614 12 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 86742196 Common dapF diaminopimelate epimerase Francci3_3514 201 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 86738947 Common - transcriptional regulator, XRE family Francci3_0229 6 None None None 86739273 Common - AIG2-like Francci3_0560 4 None None None 86739798 Nonpathogen - hypothetical protein Francci3_1087 1 None None None 86738890 Common - Kelch repeat protein Francci3_0169 25 COG3055 COG3055, Uncharacterized protein conserved in bacteria Function unknown 86739999 Common - glycosyl transferase, group 1 Francci3_1293 135 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86742802 Nonpathogen - hypothetical protein Francci3_4125 1 None None None 86741878 Common - S-adenosylmethionine synthetase Francci3_3192 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 86742450 Common - Methyltransferase type 11 Francci3_3770 2 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86742917 Common - ABC transporter related Francci3_4242 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 86741341 Common - membrane protein-like Francci3_2650 12 COG5305 COG5305, Predicted membrane protein Function unknown 86738995 Common - Pyridoxal-dependent decarboxylase Francci3_0279 92 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 86742111 Nonpathogen - Limonene-1,2-epoxide hydrolase Francci3_3428 1 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 86741263 Nonpathogen - hypothetical protein Francci3_2572 8 None None None 86741847 Nonpathogen - hypothetical protein Francci3_3161 1 None None None 86741173 Common - ABC-3 Francci3_2477 49 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 86740161 Common - Prephenate dehydrogenase Francci3_1455 143 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 86741630 Common - hypothetical protein Francci3_2943 6 None None None 86739839 Common - GCN5-related N-acetyltransferase Francci3_1131 88 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 86741010 Common - methylenetetrahydrofolate reductase Francci3_2313 31 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 86740328 Common - peptidase M4, thermolysin Francci3_1623 45 COG3227 LasB, Zinc metalloprotease (elastase) Amino acid transport and metabolism 86741287 Common - beta-ketoacyl synthase Francci3_2596 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86742045 Nonpathogen - hypothetical protein Francci3_3361 1 None None None 86742994 Common - peptidase U62, modulator of DNA gyrase Francci3_4319 163 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 86740301 Common - hypothetical protein Francci3_1596 6 None None None 86741330 Nonpathogen - hypothetical protein Francci3_2639 1 None None None 86739364 Common sucC succinyl-CoA synthetase subunit beta Francci3_0651 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 86741277 Nonpathogen - putative integral membrane protein Francci3_2586 9 COG4097 COG4097, Predicted ferric reductase Inorganic ion transport and metabolism 86740303 Nonpathogen - hypothetical protein Francci3_1598 1 None None None 86738940 Common - alpha/beta hydrolase fold Francci3_0222 179 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86740103 Nonpathogen - hypothetical protein Francci3_1397 7 None None None 86739963 Common - hypothetical protein Francci3_1256 28 COG1141 Fer, Ferredoxin Energy production and conversion 86740804 Common - putative asparagine synthetase Francci3_2103 3 None None None 86739681 Common - Peptidase M1, aminopeptidase N actinomycete-type Francci3_0968 153 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 86741737 Common - GCN5-related N-acetyltransferase Francci3_3051 50 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 86740015 Common - UDP-glucose/GDP-mannose dehydrogenase Francci3_1309 204 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 86741378 Common - Rieske (2Fe-2S) protein Francci3_2688 70 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 86740078 Nonpathogen - preprotein translocase, YajC subunit Francci3_1372 2 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 86742915 Common - ABC transporter related Francci3_4240 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 86739425 Common - cell envelope-related transcriptional attenuator Francci3_0712 62 COG1316 LytR, Transcriptional regulator Transcription 86741156 Common - Amino acid adenylation Francci3_2460 212 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 86740677 Nonpathogen - hypothetical protein Francci3_1974 3 None None None 86742672 Common - hypothetical protein Francci3_3993 5 None None None 86741533 Common - hypothetical protein Francci3_2846 6 None None None 86740117 Common - UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase Francci3_1411 195 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 86742350 Common - hypothetical protein Francci3_3669 23 None None None 86742695 Common - hypothetical protein Francci3_4016 2 None None None 86742819 Common - Acyl-CoA dehydrogenase Francci3_4142 45 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 86738987 Common - DNA polymerase III subunits gamma and tau Francci3_0270 245 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 86742725 Common - hypothetical protein Francci3_4046 34 COG3145 AlkB, Alkylated DNA repair protein DNA replication, recombination, and repair 86741610 Common - putative transmembrane protein Francci3_2923 14 None None None 86738807 Common - two component transcriptional regulator, LuxR family Francci3_0084 139 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86742620 Common - NAD-dependent epimerase/dehydratase Francci3_3941 227 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 86739492 Common - type II secretion system protein E Francci3_0779 168 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 86742960 Common - adenylate/guanylate cyclase Francci3_4285 90 COG3899 COG3899, Predicted ATPase General function prediction only 86739632 Common - hypothetical protein Francci3_0919 15 COG5373 COG5373, Predicted membrane protein Function unknown 86741020 Common - protein of unknown function DUF190 Francci3_2323 53 COG1993 COG1993, Uncharacterized conserved protein Function unknown 86742602 Common eno phosphopyruvate hydratase Francci3_3923 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 86743083 Common - GCN5-related N-acetyltransferase Francci3_4408 19 COG0456 RimI, Acetyltransferases General function prediction only 86741822 Nonpathogen - serine/threonine protein kinase Francci3_3136 2 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86741754 Nonpathogen - hypothetical protein Francci3_3068 1 None None None 86738958 Common - transcriptional regulator, TetR family Francci3_0240 19 COG1309 AcrR, Transcriptional regulator Transcription 86742945 Common - transcriptional regulator, GntR family Francci3_4270 137 COG2188 PhnF, Transcriptional regulators Transcription 86742525 Common - glycosyl transferase, family 2 Francci3_3846 49 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86741307 Common - protein of unknown function UPF0016 Francci3_2616 22 COG2119 COG2119, Predicted membrane protein Function unknown 86740878 Nonpathogen - hypothetical protein Francci3_2179 1 None None None 86742842 Common - NADPH-dependent FMN reductase Francci3_4165 38 COG0431 COG0431, Predicted flavoprotein General function prediction only 86742359 Common - alpha amylase, catalytic region Francci3_3678 85 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 86739514 Common smpB SsrA-binding protein Francci3_0801 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 86739546 Common ureB urease subunit beta Francci3_0833 96 COG0832 UreB, Urea amidohydrolase (urease) beta subunit Amino acid transport and metabolism 86742304 Common - serine/threonine protein kinase Francci3_3623 152 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86740223 Common cobN cobaltochelatase Francci3_1518 89 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 86740071 Common - hypothetical protein Francci3_1365 7 None None None 86739525 Common - ABC transporter related Francci3_0812 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 86739032 Common - Saccharopine dehydrogenase Francci3_0316 11 COG3268 COG3268, Uncharacterized conserved protein Function unknown 86738767 Common - serine/threonine protein kinase Francci3_0044 144 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86740469 Nonpathogen - transposase, IS4 Francci3_1764 8 COG5659 COG5659, FOG: Transposase DNA replication, recombination, and repair 86738757 Common - Type IV secretory pathway VirB4 components-like Francci3_0034 20 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 86742372 Nonpathogen - hypothetical protein Francci3_3691 1 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 86741838 Nonpathogen - hypothetical protein Francci3_3152 1 None None None 86738837 Common - phage integrase Francci3_0114 68 COG0582 XerC, Integrase DNA replication, recombination, and repair 86739519 Common - hypothetical protein Francci3_0806 6 None None None 86741446 Common - Drug resistance transporter EmrB/QacA subfamily Francci3_2757 153 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 86741667 Common - beta-ketoacyl synthase Francci3_2981 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 86739064 Common - short-chain dehydrogenase/reductase SDR Francci3_0348 231 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 86739386 Common - filamentation induced by cAMP protein Fic Francci3_0673 106 COG3177 COG3177, Uncharacterized conserved protein Function unknown 86739873 Common - hypothetical protein Francci3_1165 9 None None None 86739684 Nonpathogen - FHA domain containing protein Francci3_0971 7 COG3456 COG3456, Uncharacterized conserved protein, contains FHA domain Signal transduction mechanisms 86740213 Common - stress protein Francci3_1508 29 COG2310 TerZ, Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 Signal transduction mechanisms 86741937 Common - putative signal transduction histidine kinase Francci3_3251 86 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 86742236 Common - polynucleotide phosphorylase/polyadenylase Francci3_3555 236 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 86739628 Common - electron transport protein SCO1/SenC Francci3_0915 98 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 86738830 Nonpathogen - hypothetical protein Francci3_0107 3 None None None 86740637 Common - hypothetical protein Francci3_1933 13 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 86739877 Nonpathogen - hypothetical protein Francci3_1169 1 None None None 86739986 Common - hypothetical protein Francci3_1279 17 COG3402 COG3402, Uncharacterized conserved protein Function unknown 86742326 Common - glutamyl-tRNA(Gln) amidotransferase, C subunit Francci3_3645 137 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 86739624 Nonpathogen - hypothetical protein Francci3_0911 1 None None None 86739891 Common - FHA domain containing protein Francci3_1183 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 86739666 Common - ISRSO5-transposase protein Francci3_0953 37 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742792 Common - transposase, IS4 Francci3_4115 28 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86738961 Common - putative sigma factor Francci3_0244 41 COG4941 COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain Transcription 86741850 Nonpathogen - hypothetical protein Francci3_3164 4 COG4105 ComL, DNA uptake lipoprotein General function prediction only 86741683 Common - Acetyl-CoA C-acyltransferase Francci3_2997 185 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 86742457 Common - aldehyde dehydrogenase Francci3_3777 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 86742822 Common - transposase IS66 Francci3_4145 20 None None None 86743218 Nonpathogen - hypothetical protein Francci3_4543 1 None None None 86743222 Nonpathogen - ribonuclease P protein component Francci3_4547 1 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 86743091 Common - phosphoribosylformylglycinamidine synthase subunit I Francci3_4416 183 COG0047 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain Nucleotide transport and metabolism 86743155 Common - nitrogen fixation protein NifW Francci3_4480 17 None None None 86739324 Common rplQ 50S ribosomal protein L17 Francci3_0611 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 86738859 Nonpathogen - hypothetical protein Francci3_0136 1 None None None 86741918 Common - major facilitator superfamily MFS_1 Francci3_3232 13 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86743150 Common - aminotransferase, class V Francci3_4475 236 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 86741774 Common - phospholipid/glycerol acyltransferase Francci3_3088 136 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 86743196 Common - single-strand DNA-binding protein Francci3_4521 192 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 86740056 Common - Glycogen debranching enzyme GlgX Francci3_1350 156 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 86741977 Common - transcriptional regulator, AbrB family Francci3_3291 2 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 86739119 Common - protein of unknown function DUF574 Francci3_0403 6 None None None 86741608 Common - transposase, IS605 OrfB Francci3_2921 69 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739898 Nonpathogen - hypothetical protein Francci3_1190 1 None None None 86738778 Nonpathogen - hypothetical protein Francci3_0055 1 None None None 86740939 Common - Hydantoinase B/oxoprolinase Francci3_2242 92 COG0146 HyuB, N-methylhydantoinase B/acetone carboxylase, alpha subunit Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86743077 Nonpathogen - hypothetical protein Francci3_4402 1 None None None 86739933 Common - nuclease SbcCD, D subunit Francci3_1226 101 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 86740526 Common - Lantibiotic dehydratase-like Francci3_1821 6 None None None 86741335 Common - hypothetical protein Francci3_2644 17 None None None 86740817 Common - binding-protein-dependent transport systems inner membrane component Francci3_2116 190 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 86741565 Common - Cob(II)yrinic acid a,c-diamide reductase Francci3_2878 97 COG0778 NfnB, Nitroreductase Energy production and conversion 86738865 Nonpathogen - Prevent-host-death protein Francci3_0142 2 COG4118 Phd, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 86741314 Common - transcriptional regulator, TetR family Francci3_2623 57 COG1309 AcrR, Transcriptional regulator Transcription 86738915 Common - secretion protein HlyD Francci3_0196 35 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 86739163 Common - hypothetical protein Francci3_0448 7 None None None 86740128 Common - hypothetical protein Francci3_1422 3 None None None 86741242 Nonpathogen - hypothetical protein Francci3_2549 1 None None None 86740963 Nonpathogen - protein of unknown function DUF397 Francci3_2266 1 None None None 86739249 Common - Carboxymethylenebutenolidase Francci3_0536 100 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 86742242 Common - protein of unknown function DUF503 Francci3_3561 36 COG1550 COG1550, Uncharacterized protein conserved in bacteria Function unknown 86741911 Nonpathogen - hypothetical protein Francci3_3225 3 None None None 86742494 Common - hypothetical protein Francci3_3815 8 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 86739697 Common - hypothetical protein Francci3_0984 8 COG5650 COG5650, Predicted integral membrane protein Function unknown 86742975 Nonpathogen - hypothetical protein Francci3_4300 1 None None None 86743070 Common - Alpha,alpha-trehalose-phosphate synthase (UDP-forming) Francci3_4395 94 COG0380 OtsA, Trehalose-6-phosphate synthase Carbohydrate transport and metabolism 86741903 Common - recombination factor protein RarA Francci3_3217 205 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 86741106 Nonpathogen - hypothetical protein Francci3_2410 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 86740704 Common - putative homoserine O-succinyltransferase Francci3_2001 61 COG1897 MetA, Homoserine trans-succinylase Amino acid transport and metabolism 86741098 Common - undecaprenyl pyrophosphate phosphatase Francci3_2402 167 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 86742170 Nonpathogen - hypothetical protein Francci3_3488 1 None None None 86739451 Common - DNA polymerase III, beta subunit Francci3_0738 162 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 86742644 Common - TatD-related deoxyribonuclease Francci3_3965 230 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 86741356 Common - hypothetical protein Francci3_2665 2 None None None 86741985 Nonpathogen - hypothetical protein Francci3_3299 1 None None None 86740822 Common - transposase, IS4 Francci3_2121 30 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86740158 Common - chromosome segregation and condensation protein ScpA Francci3_1452 109 COG1354 COG1354, Uncharacterized conserved protein Function unknown 86741149 Common - Prephenate dehydrogenase Francci3_2453 150 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 86741228 Nonpathogen - transposase, IS4 Francci3_2534 8 COG5659 COG5659, FOG: Transposase DNA replication, recombination, and repair 86739714 Nonpathogen - hypothetical protein Francci3_1002 4 COG0716 FldA, Flavodoxins Energy production and conversion 86739925 Common - ribonuclease, Rne/Rng family Francci3_1218 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 86739486 Common - ATPases involved in chromosome partitioning-like Francci3_0773 8 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 86743186 Common - glutamate--cysteine ligase, GCS2 Francci3_4511 54 COG3572 GshA, Gamma-glutamylcysteine synthetase Coenzyme metabolism 86740829 Common - protein of unknown function DUF820 Francci3_2128 15 COG4636 Uma2, Uncharacterized protein conserved in cyanobacteria Function unknown 86742368 Common - acetyl-CoA acetyltransferase Francci3_3687 180 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 86741128 Common - glycerophosphoryl diester phosphodiesterase Francci3_2432 116 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 86741094 Common - transcriptional regulator, TetR family Francci3_2398 8 COG1309 AcrR, Transcriptional regulator Transcription 86740412 Nonpathogen - hypothetical protein Francci3_1707 1 None None None 86740371 Common - protein of unknown function DUF59 Francci3_1666 142 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 86740428 Nonpathogen - hypothetical protein Francci3_1723 1 None None None 86740378 Nonpathogen - hypothetical protein Francci3_1673 1 None None None 86740203 Common - Biotin carboxylase-like Francci3_1498 26 COG0439 AccC, Biotin carboxylase Lipid metabolism 86741749 Common - CoA-binding Francci3_3063 91 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 86742879 Common - ABC-2 Francci3_4202 11 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 86739239 Nonpathogen - hypothetical protein Francci3_0526 3 None None None 86740547 Nonpathogen - hypothetical protein Francci3_1842 1 None None None 86740840 Common - diguanylate phosphodiesterase (EAL domain) with GAF sensor Francci3_2139 161 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 86742381 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase Francci3_3700 208 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 86741365 Common - N-6 DNA methylase Francci3_2674 41 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 86740928 Common - hypothetical protein Francci3_2231 13 None None None 86743173 Common - oxidoreductase FAD/NAD(P)-binding Francci3_4498 56 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 86742783 Common - DSBA oxidoreductase Francci3_4106 84 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 86741192 Common - Radical SAM Francci3_2496 81 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 86742270 Common - Peptidase S26A, signal peptidase I Francci3_3589 124 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 86741467 Common - transcriptional regulator, MerR family Francci3_2779 103 COG0789 SoxR, Predicted transcriptional regulators Transcription 86742138 Nonpathogen - putative lipoprotein Francci3_3455 2 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 86739010 Common - Interferon-induced transmembrane protein Francci3_0294 8 None None None 86739088 Nonpathogen - hypothetical protein Francci3_0372 1 None None None 86742554 Common - fatty acid hydroxylase Francci3_3875 8 COG3000 ERG3, Sterol desaturase Lipid metabolism 86741319 Common - protein of unknown function DUF797 Francci3_2628 14 None None None 86742298 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Francci3_3617 176 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 86738963 Common - Rv0623-like transcription factor Francci3_0246 10 COG4423 COG4423, Uncharacterized protein conserved in bacteria Function unknown 86739597 Common - hypothetical protein Francci3_0884 8 None None None 86741852 Common - Tetratricopeptide TPR_2 Francci3_3166 18 None None None 86738863 Nonpathogen - hypothetical protein Francci3_0140 1 None None None 86742507 Common - protein of unknown function DUF59 Francci3_3828 229 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 86739173 Common - aldo/keto reductase Francci3_0458 199 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 86740104 Common - transcriptional regulator, SARP family Francci3_1398 29 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 86739879 Common - CopG-like DNA-binding Francci3_1171 2 COG4453 COG4453, Uncharacterized protein conserved in bacteria Function unknown 86742492 Common - aminotransferase, class I and II Francci3_3813 238 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 86738886 Common - polysaccharide deacetylase Francci3_0165 51 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 86739004 Common - Phenazine biosynthesis PhzC/PhzF protein Francci3_0288 7 COG0384 COG0384, Predicted epimerase, PhzC/PhzF homolog General function prediction only 86742277 Common - signal recognition particle-docking protein FtsY Francci3_3596 246 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 86740284 Common - glycosyl transferase, family 2 Francci3_1579 174 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86741790 Common - hypothetical protein Francci3_3104 230 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 86742280 Common - hypothetical protein Francci3_3599 6 None None None 86742131 Common - ATP-dependent helicase HrpA Francci3_3448 131 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 86739659 Nonpathogen - hypothetical protein Francci3_0946 1 None None None 86742943 Common pyrH uridylate kinase Francci3_4268 235 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 86741996 Nonpathogen - hypothetical protein Francci3_3310 1 None None None 86741929 Common - Phosphoglycerate mutase Francci3_3243 33 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 86741752 Common - beta-lactamase-like Francci3_3066 133 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 86740382 Nonpathogen - hypothetical protein Francci3_1677 1 None None None 86740544 Nonpathogen - hypothetical protein Francci3_1839 6 None None None 86740220 Nonpathogen - hypothetical protein Francci3_1515 3 None None None 86741740 Nonpathogen - hypothetical protein Francci3_3054 2 None None None 86738978 Common - Aspartate-semialdehyde dehydrogenase, USG-1 related Francci3_0261 230 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 86740692 Common - putative PAS/PAC sensor protein Francci3_1989 62 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 86741700 Common - prolipoprotein diacylglyceryl transferase Francci3_3014 150 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 86740013 Common - GDP-mannose 4,6-dehydratase Francci3_1307 216 COG1089 Gmd, GDP-D-mannose dehydratase Cell envelope biogenesis, outer membrane 86742129 Common - transcriptional regulator, XRE family Francci3_3446 6 None None None 86741244 Common - Recombinase Francci3_2551 28 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 86739286 Common rpoB DNA-directed RNA polymerase subunit beta Francci3_0573 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 86742938 Common - Phosphate transport system permease protein 2 Francci3_4263 232 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 86740471 Nonpathogen - hypothetical protein Francci3_1766 1 None None None 86739121 Common - Excisionase/Xis, DNA-binding Francci3_0405 5 None None None 86740349 Common - putative integral membrane protein Francci3_1644 8 None None None 86742973 Common - type II secretion system protein Francci3_4298 4 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 86739397 Common - cytidine deaminase Francci3_0684 98 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 86742616 Nonpathogen - membrane protein Francci3_3937 4 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 86739576 Common - molybdopterin oxidoreductase Francci3_0863 184 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 86740403 Nonpathogen - hypothetical protein Francci3_1698 1 None None None 86739886 Common - AMP-dependent synthetase and ligase Francci3_1178 200 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86739445 Common - Methyltransferase type 11 Francci3_0732 87 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86742480 Common - short-chain dehydrogenase/reductase SDR Francci3_3801 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 86740094 Common - Polyprenyl synthetase Francci3_1388 153 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 86741579 Nonpathogen - putative serine/threonine kinase anti-sigma factor Francci3_2892 2 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 86741572 Common - NUDIX hydrolase Francci3_2885 26 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 86741000 Nonpathogen - hypothetical protein Francci3_2303 1 None None None 86739814 Common - hypothetical protein Francci3_1105 6 None None None 86742749 Nonpathogen - hypothetical protein Francci3_4072 1 None None None 86743097 Common - protein of unknown function DUF191 Francci3_4422 35 COG2107 COG2107, Predicted periplasmic solute-binding protein General function prediction only 86738745 Common - hypothetical protein Francci3_0022 21 None None None 86739566 Common - ABC transporter related Francci3_0853 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 86739275 Common - glycoside hydrolase, family 25 Francci3_0562 43 COG3757 Acm, Lyzozyme M1 (1,4-beta-N-acetylmuramidase) Cell envelope biogenesis, outer membrane 86741142 Common - protein of unknown function DUF214 Francci3_2446 3 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 86742576 Common - phosphoenolpyruvate carboxykinase Francci3_3897 59 COG1274 PckA, Phosphoenolpyruvate carboxykinase (GTP) Energy production and conversion 86741663 Common - hypothetical protein Francci3_2977 3 None None None 86740433 Common - putative transposase Francci3_1728 35 COG5659 COG5659, FOG: Transposase DNA replication, recombination, and repair 86741623 Common - alpha/beta hydrolase fold Francci3_2936 27 COG4757 COG4757, Predicted alpha/beta hydrolase General function prediction only 86739732 Common - formyl transferase-like Francci3_1020 218 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 86740565 Common - cytochrome P450 Francci3_1860 70 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 86740941 Common - acetyl-CoA acetyltransferase Francci3_2244 90 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 86742151 Nonpathogen - hypothetical protein Francci3_3468 3 None None None 86741797 Common - Rubrerythrin Francci3_3111 79 COG1592 COG1592, Rubrerythrin Energy production and conversion 86739560 Common - hypothetical protein Francci3_0847 6 None None None 86740582 Common - transposase, IS4 Francci3_1877 13 None None None 86741444 Common - pyoverdine biosynthesis protein Francci3_2755 16 COG2175 TauD, Probable taurine catabolism dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 86738918 Common - ABC transporter related Francci3_0199 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 86742229 Common hisS histidyl-tRNA synthetase Francci3_3548 246 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86741417 Common - hypothetical protein Francci3_2728 60 None None None 86740039 Nonpathogen - hypothetical protein Francci3_1333 1 None None None 86742077 Nonpathogen - hypothetical protein Francci3_3394 1 None None None 86740899 Common - carboxyvinyl-carboxyphosphonate phosphorylmutase, putative Francci3_2201 45 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 86738802 Common - pyridoxamine 5'-phosphate oxidase Francci3_0079 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 86741499 Nonpathogen - hypothetical protein Francci3_2812 2 None None None 86738876 Common - protein of unknown function DUF86 Francci3_0153 41 COG2361 COG2361, Uncharacterized conserved protein Function unknown 86742820 Common - actinorhodin polyketide synthase bifunctional cyclase/dehydratase Francci3_4143 5 None None None 86739600 Nonpathogen - hypothetical protein Francci3_0887 2 None None None 86739053 Common - hypothetical protein Francci3_0337 5 None None None 86741383 Nonpathogen - hypothetical protein Francci3_2693 1 None None None 86743178 Common - DoxX Francci3_4503 20 COG2259 COG2259, Predicted membrane protein Function unknown 86738818 Common - phosphoribosylaminoimidazole synthetase Francci3_0095 224 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 86740054 Nonpathogen - hypothetical protein Francci3_1348 1 None None None 86742243 Common infB translation initiation factor IF-2 Francci3_3562 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 86739411 Common - Carbamoyl-phosphate synthase L chain, ATP-binding Francci3_0698 236 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 86740609 Common - hypothetical protein Francci3_1904 9 None None None 86741828 Common - glutamine synthetase, type I Francci3_3142 224 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 86739232 Common - hypothetical protein Francci3_0519 81 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 86740024 Common - deoxyuridine 5'-triphosphate nucleotidohydrolase Francci3_1318 175 COG0756 Dut, dUTPase Nucleotide transport and metabolism 86740885 Common - hypothetical protein Francci3_2187 7 COG1846 MarR, Transcriptional regulators Transcription 86740508 Common - Radical SAM Francci3_1803 17 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 86739650 Common - pyridine nucleotide-disulphide oxidoreductase dimerisation region Francci3_0937 226 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 86741453 Common - ABC transporter related Francci3_2764 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 86741460 Common - hypothetical protein Francci3_2771 2 None None None 86739954 Common - protein of unknown function DUF75 Francci3_1247 20 COG1938 COG1938, Archaeal enzymes of ATP-grasp superfamily General function prediction only 86739868 Common - Peptidase M1, aminopeptidase N actinomycete-type Francci3_1160 164 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 86740615 Common - Urate oxidase Francci3_1910 14 COG3648 COG3648, Uricase (urate oxidase) Secondary metabolites biosynthesis, transport, and catabolism 86739295 Common - ribosomal protein L3 Francci3_0582 238 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 86738731 Nonpathogen - hypothetical protein Francci3_0008 1 COG5373 COG5373, Predicted membrane protein Function unknown 86739095 Common - ABC transporter related Francci3_0379 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 86742547 Common - protein of unknown function DUF952 Francci3_3868 33 COG3502 COG3502, Uncharacterized protein conserved in bacteria Function unknown 86740560 Common - hypothetical protein Francci3_1855 7 None None None 86740665 Common - hypothetical protein Francci3_1961 8 COG0384 COG0384, Predicted epimerase, PhzC/PhzF homolog General function prediction only 86742933 Common - DNA repair protein RadA Francci3_4258 201 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 86740445 Nonpathogen - hypothetical protein Francci3_1740 1 None None None 86740920 Common - putative transmembrane efflux protein Francci3_2223 148 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86739131 Nonpathogen - TrkA-like Francci3_0415 2 COG1226 Kch, Kef-type K+ transport systems, predicted NAD-binding component Inorganic ion transport and metabolism 86740815 Common - alpha/beta hydrolase fold Francci3_2114 59 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86739803 Common - hypothetical protein Francci3_1093 4 COG2442 COG2442, Uncharacterized conserved protein Function unknown 86739674 Common - transposase, IS4 Francci3_0961 6 None None None 86739770 Common - Glutathione peroxidase Francci3_1059 114 COG0386 BtuE, Glutathione peroxidase Posttranslational modification, protein turnover, chaperones 86740883 Nonpathogen - hypothetical protein Francci3_2184 1 None None None 86742188 Common - hypothetical protein Francci3_3506 36 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 86740421 Nonpathogen - hypothetical protein Francci3_1716 1 None None None 86740740 Common - transposase, IS4 Francci3_2037 56 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86738852 Nonpathogen - hypothetical protein Francci3_0129 1 None None None 86739538 Common - putative transcriptional regulator Francci3_0825 131 COG1733 COG1733, Predicted transcriptional regulators Transcription 86739221 Common - Phosphoglycerate mutase Francci3_0508 28 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 86739754 Nonpathogen - hypothetical protein Francci3_1043 3 None None None 86741695 Common - Tellurite resistance TerB Francci3_3009 12 COG3793 TerB, Tellurite resistance protein Inorganic ion transport and metabolism 86739592 Nonpathogen - hypothetical protein Francci3_0879 1 None None None 86741511 Common - protein of unknown function DUF742 Francci3_2824 7 None None None 86739343 Common - transcriptional regulator, MarR family Francci3_0630 60 COG1846 MarR, Transcriptional regulators Transcription 86740168 Common - CDP-alcohol phosphatidyltransferase Francci3_1462 174 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 86739500 Nonpathogen - hypothetical protein Francci3_0787 1 None None None 86741184 Common - pyruvate dehydrogenase Francci3_2488 154 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 86740491 Nonpathogen - hypothetical protein Francci3_1786 1 None None None 86739083 Common - short-chain dehydrogenase/reductase SDR Francci3_0367 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 86739540 Common - Radical SAM Francci3_0827 99 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 86740579 Nonpathogen - hypothetical protein Francci3_1874 6 None None None 86740755 Common - transposase, IS4 Francci3_2052 28 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86742851 Common - copper resistance protein CopC Francci3_4174 32 COG1276 PcoD, Putative copper export protein Inorganic ion transport and metabolism 86738729 Common gyrB DNA gyrase subunit B Francci3_0006 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 86739702 Common - 3-oxoacyl-(acyl-carrier-protein) synthase III Francci3_0990 203 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 86741293 Common - ABC transporter related Francci3_2602 249 COG4152 COG4152, ABC-type uncharacterized transport system, ATPase component General function prediction only 86742021 Nonpathogen - hypothetical protein Francci3_3335 1 None None None 86742208 Common - hypothetical protein Francci3_3526 15 None None None 86741964 Common - hypothetical protein Francci3_3278 15 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 86742172 Common - Molybdopterin-guanine dinucleotide biosynthesis protein A-like Francci3_3490 10 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 86740115 Common - Peptidoglycan glycosyltransferase Francci3_1409 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 86740952 Common - ABC transporter related Francci3_2255 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 86742168 Common - major facilitator superfamily MFS_1 Francci3_3486 90 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86742829 Common - hypothetical protein Francci3_4152 17 COG5563 COG5563, Predicted integral membrane proteins containing uncharacterized repeats Function unknown 86740720 Common - hypothetical protein Francci3_2017 17 None None None 86743116 Common - hypothetical protein Francci3_4441 4 None None None 86743086 Common - ATPases involved in chromosome partitioning-like Francci3_4411 14 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 86742864 Common - biotin synthase Francci3_4187 174 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 86739942 Common - transposase, IS4 Francci3_1235 8 None None None 86743164 Common - pyruvate carboxyltransferase Francci3_4489 203 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 86739845 Nonpathogen - hypothetical protein Francci3_1137 1 None None None 86742094 Nonpathogen - Forkhead-associated Francci3_3411 1 None None None 86739420 Common - GtrA-like protein Francci3_0707 19 COG2246 COG2246, Predicted membrane protein Function unknown 86738923 Nonpathogen - putative O-methyltransferase Francci3_0204 3 None None None 86743206 Common - metal dependent phosphohydrolase Francci3_4531 212 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 86739939 Common nadD nicotinic acid mononucleotide adenyltransferase Francci3_1232 187 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 86741866 Common rplT 50S ribosomal protein L20 Francci3_3180 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 86739992 Common - hypothetical protein Francci3_1285 99 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86742313 Common - 3-isopropylmalate dehydrogenase Francci3_3632 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 86739824 Common - acyl transferase region Francci3_1115 53 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 86738849 Common - hypothetical protein Francci3_0126 11 COG1746 CCA1, tRNA nucleotidyltransferase (CCA-adding enzyme) Translation, ribosomal structure and biogenesis 86742461 Common - protein of unknown function UPF0182 Francci3_3781 48 COG1615 COG1615, Uncharacterized conserved protein Function unknown 86740517 Nonpathogen - Thymidylate kinase-like Francci3_1812 2 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 86741404 Common - CMP/dCMP deaminase, zinc-binding Francci3_2714 194 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 86741412 Common - protein of unknown function DUF574 Francci3_2723 12 None None None 86740595 Nonpathogen - hypothetical protein Francci3_1890 2 None None None 86739046 Common - transcriptional regulator, MarR family Francci3_0330 29 COG1846 MarR, Transcriptional regulators Transcription 86739069 Common - hypothetical protein Francci3_0353 2 None None None 86741955 Nonpathogen - peptidase C45, acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Francci3_3269 3 COG4927 COG4927, Predicted choloylglycine hydrolase General function prediction only 86742289 Common rpmB 50S ribosomal protein L28 Francci3_3608 51 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 86740063 Common - cell wall hydrolase/autolysin Francci3_1357 16 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 86742905 Common - cyclic nucleotide-binding domain (cNMP-BD) protein Francci3_4230 31 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 86742330 Common trmU tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Francci3_3649 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 86739792 Common - hypothetical protein Francci3_1081 9 None None None 86739974 Common - PhoH-like protein Francci3_1267 199 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 86742681 Common - hypothetical protein Francci3_4002 4 None None None 86743001 Common - hypothetical protein Francci3_4326 7 COG4578 GutM, Glucitol operon activator Transcription 86738938 Nonpathogen - hypothetical protein Francci3_0220 2 COG5280 COG5280, Phage-related minor tail protein Function unknown 86742484 Common - Ku protein Francci3_3805 63 COG1273 COG1273, Uncharacterized conserved protein Function unknown 86742740 Common - transcriptional regulator, TetR family Francci3_4061 23 COG1309 AcrR, Transcriptional regulator Transcription 86742858 Nonpathogen - hypothetical protein Francci3_4181 2 None None None 86739070 Nonpathogen - hypothetical protein Francci3_0354 1 None None None 86740048 Common - Sulfate adenylyltransferase, large subunit Francci3_1342 249 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 86741261 Nonpathogen - hypothetical protein Francci3_2570 1 None None None 86739808 Common - purine and other phosphorylases, family 1 Francci3_1098 17 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 86741726 Common - alpha/beta hydrolase fold Francci3_3040 52 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86739462 Common - hypothetical protein Francci3_0749 16 COG3824 COG3824, Uncharacterized protein conserved in bacteria Function unknown 86739744 Nonpathogen - hypothetical protein Francci3_1032 1 None None None 86742404 Common - homoserine kinase Francci3_3723 47 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 86742776 Common - phosphopantetheine-binding Francci3_4099 4 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86740293 Nonpathogen - hypothetical protein Francci3_1588 1 None None None 86740863 Common - transcriptional regulator, LacI family Francci3_2164 126 COG1609 PurR, Transcriptional regulators Transcription 86740029 Common - TrkA-like Francci3_1323 128 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 86741155 Common - Amino acid adenylation Francci3_2459 218 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 86740368 Common - FeS assembly ATPase SufC Francci3_1663 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 86739644 Nonpathogen - hypothetical protein Francci3_0931 6 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 86738785 Nonpathogen - hypothetical protein Francci3_0062 1 None None None 86742198 Common miaA tRNA delta(2)-isopentenylpyrophosphate transferase Francci3_3516 214 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 86740031 Common - deoxyribonuclease/rho related TRAM Francci3_1325 168 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 86741543 Nonpathogen - regulatory protein, LuxR Francci3_2856 6 COG1378 COG1378, Predicted transcriptional regulators Transcription 86742701 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Francci3_4022 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 86739622 Common - protein of unknown function DUF955 Francci3_0909 12 COG2856 COG2856, Predicted Zn peptidase Amino acid transport and metabolism 86741086 Common - glycosyl transferase, family 39 Francci3_2390 17 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 86740040 Common - uroporphyrinogen decarboxylase Francci3_1334 179 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 86743040 Common - Transglycosylase-like Francci3_4365 13 COG3409 COG3409, Putative peptidoglycan-binding domain-containing protein Cell envelope biogenesis, outer membrane 86742874 Nonpathogen - hypothetical protein Francci3_4197 1 None None None 86741495 Common - hypothetical protein Francci3_2808 7 COG3832 COG3832, Uncharacterized conserved protein Function unknown 86740613 Nonpathogen - hypothetical protein Francci3_1908 3 None None None 86739403 Common - phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I Francci3_0690 98 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 86742087 Common - Tat-translocated enzyme Francci3_3404 44 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 86740986 Common - major facilitator superfamily MFS_1 Francci3_2289 166 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86742862 Common - serine/threonine protein kinase Francci3_4185 149 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86741646 Nonpathogen - hypothetical protein Francci3_2959 1 COG4226 HicB, Uncharacterized protein encoded in hypervariable junctions of pilus gene clusters Function unknown 86740716 Common - Phosphoenolpyruvate synthase/pyruvate phosphate dikinase-like Francci3_2013 130 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 86739310 Common - ribosomal protein L6 Francci3_0597 243 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 86739214 Common - hypothetical protein Francci3_0500 4 None None None 86740839 Common - putative serine/threonine kinase anti-sigma factor Francci3_2138 8 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 86742656 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Francci3_3977 23 None None None 86740194 Common - Rhomboid-like protein Francci3_1489 76 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 86742959 Common - beta-lactamase-like Francci3_4284 116 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 86739258 Common - NADH dehydrogenase subunit H Francci3_0545 184 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 86739763 Nonpathogen - hypothetical protein Francci3_1052 1 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 86739916 Common - Folylpolyglutamate synthase-like Francci3_1209 19 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 86740084 Common - CutA1 divalent ion tolerance protein Francci3_1378 119 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 86739558 Common - amidohydrolase Francci3_0845 169 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 86740999 Nonpathogen - hypothetical protein Francci3_2302 1 None None None 86740761 Nonpathogen - hypothetical protein Francci3_2059 4 None None None 86740977 Nonpathogen - hypothetical protein Francci3_2280 1 None None None 86738751 Common - OsmC-like protein Francci3_0028 96 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 86739871 Nonpathogen - hypothetical protein Francci3_1163 1 None None None 86741238 Common - PfkB Francci3_2545 5 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 86742591 Common - hypothetical protein Francci3_3912 25 COG2845 COG2845, Uncharacterized protein conserved in bacteria Function unknown 86742201 Common - ABC transporter related Francci3_3519 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 86741231 Common - putative DNA-binding protein Francci3_2538 7 None None None 86742831 Common - Drug resistance transporter EmrB/QacA subfamily Francci3_4154 208 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86739317 Common - methionine aminopeptidase, type I Francci3_0604 245 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 86740261 Common - serine phosphatase Francci3_1556 71 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 86740774 Common - Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)-like Francci3_2072 15 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 86742952 Common - glycosyl transferase, family 51 Francci3_4277 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 86740315 Common - protein of unknown function DUF305 Francci3_1610 42 COG3544 COG3544, Uncharacterized protein conserved in bacteria Function unknown 86740173 Common - glycine cleavage system H protein Francci3_1467 187 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 86742314 Common - diguanylate phosphodiesterase (EAL domain) Francci3_3633 157 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 86739124 Common - major facilitator superfamily MFS_1 Francci3_0408 47 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 86741628 Common - transposase, IS4 Francci3_2941 28 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86739434 Common - glycosyl transferase, group 1 Francci3_0721 25 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86743191 Nonpathogen - hypothetical protein Francci3_4516 1 None None None 86738971 Common - peptidase M48, Ste24p Francci3_0254 13 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 86740277 Nonpathogen - Parallel beta-helix repeat protein Francci3_1572 4 None None None 86740964 Common - putative DNA-binding protein Francci3_2267 6 None None None 86742321 Common - acetolactate synthase 1 catalytic subunit Francci3_3640 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 86741025 Nonpathogen - hypothetical protein Francci3_2328 1 None None None 86742255 Common - peptidase M50 Francci3_3574 197 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 86739527 Common - NAD-dependent epimerase/dehydratase Francci3_0814 60 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 86740376 Common - cation diffusion facilitator family transporter Francci3_1671 94 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 86741028 Common - putative protease Francci3_2331 37 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86739231 Nonpathogen - hypothetical protein Francci3_0518 1 None None None 86741539 Common - Cupin 2 Francci3_2852 8 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 86738792 Common - peptidase S1 and S6, chymotrypsin/Hap Francci3_0069 221 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 86738747 Common - CRISPR-associated protein, Cas2 Francci3_0024 28 None None None 86742761 Common - hypothetical protein Francci3_4084 9 COG4634 COG4634, Uncharacterized protein conserved in bacteria Function unknown 86742974 Nonpathogen - TadE-like Francci3_4299 2 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 86739930 Common - gamma-glutamyl kinase Francci3_1223 189 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 86741337 Common - Exodeoxyribonuclease V Francci3_2646 113 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 86742836 Nonpathogen - hypothetical protein Francci3_4159 1 None None None 86739488 Common - Patatin Francci3_0775 22 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 86743064 Nonpathogen - hypothetical protein Francci3_4389 1 None None None 86738853 Common - transposase IS116/IS110/IS902 Francci3_0130 47 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740246 Common - GntR-like Francci3_1541 22 COG2186 FadR, Transcriptional regulators Transcription 86740397 Nonpathogen - hypothetical protein Francci3_1692 1 None None None 86741971 Common - K+ transporting ATPase, KdpC subunit Francci3_3285 92 COG2156 KdpC, K+-transporting ATPase, c chain Inorganic ion transport and metabolism 86742088 Common - Twin-arginine translocation pathway signal Francci3_3405 34 COG3211 PhoX, Predicted phosphatase General function prediction only 86743157 Common - protein of unknown function DUF269 Francci3_4482 25 None None None 86739117 Nonpathogen - hypothetical protein Francci3_0401 1 None None None 86741689 Common - Heat shock protein 70 Francci3_3003 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 86742722 Nonpathogen - hypothetical protein Francci3_4043 1 None None None 86741886 Common - hypothetical protein Francci3_3200 8 None None None 86739326 Common - hypothetical protein Francci3_0613 2 None None None 86742825 Common - beta-ketoacyl synthase Francci3_4148 204 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86743208 Common - integral membrane protein MviN Francci3_4533 177 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 86742730 Common - putative serine/threonine kinase anti-sigma factor Francci3_4051 7 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 86740185 Common - putative phosphohistidine phosphatase, SixA Francci3_1480 77 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 86742459 Common - transcriptional regulator, AsnC family Francci3_3779 139 COG1522 Lrp, Transcriptional regulators Transcription 86742718 Common - MoeA-like protein Francci3_4039 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 86739247 Common - adenosine deaminase Francci3_0534 97 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 86739037 Common - two component transcriptional regulator, winged helix family Francci3_0321 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86738772 Common - ABC-type multidrug transport system ATPase component-like Francci3_0049 244 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 86741560 Common - L-lysine aminotransferase Francci3_2873 236 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 86740944 Common - Butyryl-CoA dehydrogenase Francci3_2247 166 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 86741983 Nonpathogen - hypothetical protein Francci3_3297 1 None None None 86741775 Common - putative esterase/lipase Francci3_3089 64 COG1647 COG1647, Esterase/lipase General function prediction only 86738782 Common - hypothetical protein Francci3_0059 11 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 86742176 Common - hypothetical protein Francci3_3494 12 None None None 86741776 Nonpathogen - hypothetical protein Francci3_3090 1 None None None 86742210 Common - sigma-24 Francci3_3528 8 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 86742521 Common - Serine acetyltransferase-like Francci3_3842 206 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 86741484 Common - undecaprenyl pyrophosphate phosphatase Francci3_2797 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 86741644 Common - DEAD/DEAH box helicase-like Francci3_2957 167 COG1201 Lhr, Lhr-like helicases General function prediction only 86739110 Common - Cupin 4 Francci3_0394 24 COG2850 COG2850, Uncharacterized conserved protein Function unknown 86740933 Nonpathogen - hypothetical protein Francci3_2236 1 None None None 86741507 Nonpathogen - hypothetical protein Francci3_2820 1 None None None 86742219 Common - Competence-damaged protein Francci3_3538 211 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 86740105 Nonpathogen - hypothetical protein Francci3_1399 1 None None None 86741597 Common - Asparagine synthase, glutamine-hydrolyzing Francci3_2910 151 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 86739022 Common - thymidylate kinase Francci3_0306 12 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 86742775 Common - actinorhodin polyketide synthase bifunctional cyclase/dehydratase Francci3_4098 5 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 86742977 Common - anti-sigma-factor antagonist (STAS) domain protein Francci3_4302 60 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 86742996 Common - hypothetical protein Francci3_4321 12 None None None 86741876 Common fmt methionyl-tRNA formyltransferase Francci3_3190 214 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 86742669 Common - transposase, IS4 Francci3_3990 28 None None None 86740926 Common - hypothetical protein Francci3_2229 10 None None None 86741654 Nonpathogen - hypothetical protein Francci3_2968 1 None None None 86742885 Common - two component transcriptional regulator, LuxR family Francci3_4209 156 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86741990 Nonpathogen - hypothetical protein Francci3_3304 1 None None None 86739859 Common - serine phosphatase Francci3_1151 100 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 86741612 Common - HpcH/HpaI aldolase Francci3_2925 110 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 86742637 Common - 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase Francci3_3958 57 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 86740156 Common - Cobyrinic acid a,c-diamide synthase Francci3_1450 224 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 86740468 Common - putative transposase Francci3_1763 35 COG5659 COG5659, FOG: Transposase DNA replication, recombination, and repair 86740073 Common - SNO glutamine amidotransferase Francci3_1367 86 COG0311 PDX2, Predicted glutamine amidotransferase involved in pyridoxine biosynthesis Coenzyme metabolism 86739755 Nonpathogen - hypothetical protein Francci3_1044 2 None None None 86739922 Common - cell cycle protein Francci3_1215 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 86739481 Nonpathogen - hypothetical protein Francci3_0768 2 None None None 86739103 Nonpathogen - hypothetical protein Francci3_0387 2 COG4634 COG4634, Uncharacterized protein conserved in bacteria Function unknown 86738840 Common - putative IS630 family transposase Francci3_0117 22 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740131 Common - peptidase A8, signal peptidase II Francci3_1425 20 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 86742811 Common - NDP-hexose 2,3-dehydratase Francci3_4134 9 None None None 86742294 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase Francci3_3613 208 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 86739061 Common - ABC transporter related Francci3_0345 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 86740596 Nonpathogen - hypothetical protein Francci3_1891 1 None None None 86742063 Common - ExsB Francci3_3379 178 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 86742818 Nonpathogen - hydroxylacyl-CoA dehydrogenase Francci3_4141 2 COG5517 COG5517, Small subunit of phenylpropionate dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 86739594 Common - transposase IS66 Francci3_0881 39 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741756 Common thiE thiamine-phosphate pyrophosphorylase Francci3_3070 117 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 86741531 Nonpathogen - hypothetical protein Francci3_2844 1 None None None 86742798 Common - hypothetical protein Francci3_4121 4 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742784 Common - Integrase Francci3_4107 47 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741021 Common - Camphor resistance CrcB protein Francci3_2324 8 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 86741095 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Francci3_2399 8 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 86741409 Nonpathogen - hypothetical protein Francci3_2720 1 None None None 86742246 Common - protein of unknown function DUF150 Francci3_3565 18 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 86742670 Common - hypothetical protein Francci3_3991 6 None None None 86742895 Common - hypothetical protein Francci3_4219 30 None None None 86742054 Common - cobalamin B12-binding Francci3_3370 103 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 86739927 Common - ribosomal protein L21 Francci3_1220 199 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 86739517 Common - protein of unknown function DUF1275 Francci3_0804 5 COG3619 COG3619, Predicted membrane protein Function unknown 86739682 Common - hypothetical protein Francci3_0969 4 None None None 86739776 Common - hypothetical protein Francci3_1065 9 None None None 86738769 Nonpathogen - anti-sigma-factor antagonist (STAS) domain protein Francci3_0046 1 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 86738867 Common - transposase IS66 Francci3_0144 44 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742039 Common - Benzoate membrane transport protein Francci3_3355 54 COG3135 BenE, Uncharacterized protein involved in benzoate metabolism Secondary metabolites biosynthesis, transport, and catabolism 86743048 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase Francci3_4373 141 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 86742013 Nonpathogen - Peptidoglycan-binding LysM Francci3_3327 3 COG3170 FimV, Tfp pilus assembly protein FimV Cell motility and secretion / Intracellular trafficking and secretion 86741698 Common gltD glutamate synthase subunit beta Francci3_3012 210 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 86740756 Common - phage integrase-like SAM-like Francci3_2053 12 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86739892 Common - glycosyl transferase, group 1 Francci3_1184 82 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86742966 Nonpathogen - hypothetical protein Francci3_4291 1 None None None 86740122 Common - Mycobacterium tuberculosis paralogous family 11 Francci3_1416 11 None None None 86742130 Common - putative signal transduction histidine kinase Francci3_3447 12 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 86741510 Common - Proline dehydrogenase Francci3_2823 46 COG0506 PutA, Proline dehydrogenase Amino acid transport and metabolism 86740639 Nonpathogen - hypothetical protein Francci3_1935 1 None None None 86741958 Common - AMP-dependent synthetase and ligase Francci3_3272 208 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 86741517 Common - O-acetylhomoserine aminocarboxypropyltransferase Francci3_2830 206 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 86739660 Common - FHA domain containing protein Francci3_0947 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 86742948 Common - putative plasmid replication initiator protein Francci3_4273 5 None None None 86741567 Common - hypothetical protein Francci3_2880 20 COG5464 COG5464, Uncharacterized conserved protein Function unknown 86738917 Common - protein of unknown function DUF214 Francci3_0198 191 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 86740744 Nonpathogen - hypothetical protein Francci3_2041 1 None None None 86741161 Common - tryptophan halogenase Francci3_2465 134 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 86741935 Common - serine phosphatase Francci3_3249 59 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 86741590 Common - protein of unknown function DUF124 Francci3_2903 30 COG2013 COG2013, Uncharacterized conserved protein Function unknown 86742607 Common - nucleoside triphosphate pyrophosphohydrolase Francci3_3928 153 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 86741818 Common gcvT glycine cleavage system aminomethyltransferase T Francci3_3132 178 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 86741144 Common - protein of unknown function DUF214 Francci3_2448 5 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 86740112 Common - hypothetical protein Francci3_1406 138 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 86742493 Common - hypothetical protein Francci3_3814 12 COG2887 COG2887, RecB family exonuclease DNA replication, recombination, and repair 86739085 Common - acyl-CoA dehydrogenase-like Francci3_0369 130 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 86739058 Common - inner-membrane translocator Francci3_0342 149 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 86742432 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Francci3_3752 163 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 86740603 Common - cation diffusion facilitator family transporter Francci3_1898 168 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 86741947 Common - hypothetical protein Francci3_3261 6 None None None 86742447 Common - anti-sigma factor Francci3_3767 12 COG5660 COG5660, Predicted integral membrane protein Function unknown 86739068 Common - luciferase-like Francci3_0352 111 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 86739454 Common - F420-0--gamma-glutamyl ligase Francci3_0741 44 COG1478 COG1478, Uncharacterized conserved protein Function unknown 86742679 Common - transposase IS66 Francci3_4000 39 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741011 Nonpathogen - hypothetical protein Francci3_2314 2 None None None 86742840 Nonpathogen - hypothetical protein Francci3_4163 1 None None None 86741932 Common - FAD dependent oxidoreductase Francci3_3246 47 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 86740083 Common - (p)ppGpp synthetase I Francci3_1377 207 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 86740241 Common - transcriptional regulator, LuxR family Francci3_1536 112 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86741389 Nonpathogen - hypothetical protein Francci3_2699 1 None None None 86739355 Common - protein of unknown function DUF742 Francci3_0642 9 None None None 86740309 Common - cytochrome P450 Francci3_1604 87 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 86739672 Common - hypothetical protein Francci3_0959 42 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 86742306 Nonpathogen - hypothetical protein Francci3_3625 1 None None None 86741382 Common - small multidrug resistance protein Francci3_2692 138 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 86742692 Nonpathogen - transposase, IS4 Francci3_4013 8 COG5659 COG5659, FOG: Transposase DNA replication, recombination, and repair 86742739 Common - hypothetical protein Francci3_4060 38 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 86739969 Common - GTP-binding protein LepA Francci3_1262 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 86742684 Nonpathogen - hypothetical protein Francci3_4005 2 None None None 86739159 Common - hypothetical protein Francci3_0444 4 None None None 86739905 Common - HNH endonuclease Francci3_1198 15 COG1403 McrA, Restriction endonuclease Defense mechanisms 86742412 Common - transposase, IS204/IS1001/IS1096/IS1165 Francci3_3732 23 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741925 Common - transcriptional regulator, ArsR family Francci3_3239 144 COG0640 ArsR, Predicted transcriptional regulators Transcription 86739728 Common - transposase IS116/IS110/IS902 Francci3_1016 28 None None None 86739834 Nonpathogen - hypothetical protein Francci3_1125 3 None None None 86739365 Common - succinyl-CoA synthetase subunit alpha Francci3_0652 214 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 86742599 Common - Ppx/GppA phosphatase Francci3_3920 179 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 86739694 Common - hypothetical protein Francci3_0981 8 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 86740557 Nonpathogen - hypothetical protein Francci3_1852 2 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 86743134 Common - undecaprenyl pyrophosphate phosphatase Francci3_4459 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 86740765 Nonpathogen - hypothetical protein Francci3_2063 1 None None None 86740018 Common - aconitate hydratase 1 Francci3_1312 218 COG1048 AcnA, Aconitase A Energy production and conversion 86742590 Common - membrane bound O-acyl transferase, MBOAT Francci3_3911 85 COG1696 DltB, Predicted membrane protein involved in D-alanine export Cell envelope biogenesis, outer membrane 86740700 Common - major facilitator superfamily MFS_1 Francci3_1997 60 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86741275 Nonpathogen - hypothetical protein Francci3_2584 1 None None None 86740775 Common - transposase IS66 Francci3_2073 39 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742090 Common - hypothetical protein Francci3_3407 9 COG1503 eRF1, Peptide chain release factor 1 (eRF1) Translation, ribosomal structure and biogenesis 86739134 Common - lysyl-tRNA synthetase Francci3_0418 242 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 86739254 Common - NADH dehydrogenase subunit D Francci3_0541 191 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 86741844 Common - DNA repair protein RecN Francci3_3158 197 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 86738895 Common - serine phosphatase Francci3_0174 69 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 86740567 Common - aminotransferase, class I and II Francci3_1862 240 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 86741436 Nonpathogen - hypothetical protein Francci3_2747 2 None None None 86742034 Nonpathogen - hypothetical protein Francci3_3348 1 None None None 86740235 Common - hypothetical protein Francci3_1530 6 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 86740256 Common - transcriptional regulator, TetR family Francci3_1551 55 COG1309 AcrR, Transcriptional regulator Transcription 86742855 Common - monooxygenase, FAD-binding Francci3_4178 21 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 86742646 Common - protein of unknown function DUF218 Francci3_3967 7 COG1434 COG1434, Uncharacterized conserved protein Function unknown 86741288 Common - putative PAS/PAC sensor protein Francci3_2597 66 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 86739548 Common - amidohydrolase Francci3_0835 63 COG1001 AdeC, Adenine deaminase Nucleotide transport and metabolism 86739704 Common - transcriptional regulator, LuxR family Francci3_0992 71 COG3903 COG3903, Predicted ATPase General function prediction only 86740292 Common - polysaccharide deacetylase Francci3_1587 80 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 86738967 Common - binding-protein-dependent transport systems inner membrane component Francci3_0250 166 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 86740483 Common - Transposase and inactivated derivatives-like Francci3_1778 41 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 86738997 Nonpathogen - hypothetical protein Francci3_0281 2 None None None 86740997 Common - pentapeptide repeat Francci3_2300 9 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 86740064 Common - Anthranilate synthase component I and chorismate binding protein Francci3_1358 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 86741104 Common - SNF2-related Francci3_2408 126 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 86740630 Common - Cyclopropane-fatty-acyl-phospholipid synthase Francci3_1926 127 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 86742194 Common - transcriptional regulator, AraC family Francci3_3512 56 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 86738881 Nonpathogen - hypothetical protein Francci3_0160 1 None None None 86739278 Common - MaoC-like dehydratase Francci3_0565 53 COG2030 MaoC, Acyl dehydratase Lipid metabolism 86739051 Nonpathogen - hypothetical protein Francci3_0335 1 None None None 86741167 Common - Na+/solute symporter Francci3_2471 31 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 86741259 Nonpathogen - hypothetical protein Francci3_2568 4 COG1432 COG1432, Uncharacterized conserved protein Function unknown 86738894 Nonpathogen - hypothetical protein Francci3_0173 1 None None None 86741796 Common - hypothetical protein Francci3_3110 14 None None None 86739735 Nonpathogen - hypothetical protein Francci3_1023 1 None None None 86741111 Common - Ketopantoate reductase ApbA/PanE-like Francci3_2415 125 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 86741559 Common - aldehyde dehydrogenase Francci3_2872 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 86740789 Common - Recombinase Francci3_2088 24 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 86740709 Common - Antibiotic biosynthesis monooxygenase Francci3_2006 18 COG1359 COG1359, Uncharacterized conserved protein Function unknown 86740623 Common - catalase/peroxidase HPI Francci3_1918 98 COG0376 KatG, Catalase (peroxidase I) Inorganic ion transport and metabolism 86743096 Nonpathogen - Nucleoside phosphorylase-like Francci3_4421 8 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 86738910 Common - Rieske (2Fe-2S) protein Francci3_0190 93 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 86743022 Common - glycoside hydrolase family 65, central catalytic Francci3_4347 50 COG1554 ATH1, Trehalose and maltose hydrolases (possible phosphorylases) Carbohydrate transport and metabolism 86743017 Nonpathogen - hypothetical protein Francci3_4342 1 None None None 86741269 Nonpathogen - hypothetical protein Francci3_2578 1 None None None 86740915 Nonpathogen - hypothetical protein Francci3_2217 1 None None None 86739695 Nonpathogen - hypothetical protein Francci3_0982 1 None None None 86741136 Nonpathogen - hypothetical protein Francci3_2440 1 None None None 86740780 Common - transposase IS66 Francci3_2078 39 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 86743160 Common - nitrogenase MoFe cofactor biosynthesis protein NifE Francci3_4485 55 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 86742926 Common cysS cysteinyl-tRNA synthetase Francci3_4251 243 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86740007 Common - glycosyl transferase, family 2 Francci3_1301 101 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86740753 Common - AMP-dependent synthetase and ligase Francci3_2050 159 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86741254 Nonpathogen - hypothetical protein Francci3_2563 3 None None None 86741347 Common - 2-methylcitrate dehydratase Francci3_2656 65 COG2079 PrpD, Uncharacterized protein involved in propionate catabolism General function prediction only 86740365 Common - FeS assembly protein SufB Francci3_1660 187 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 86742465 Common - molybdopterin biosynthesis MoaE Francci3_3785 69 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 86739915 Common - FolC bifunctional protein Francci3_1208 211 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 86741739 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Francci3_3053 230 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 86742514 Nonpathogen - hypothetical protein Francci3_3835 2 None None None 86740179 Common - ABC-2 Francci3_1473 120 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 86741457 Common - transcriptional regulator, XRE family Francci3_2768 41 None None None 86742081 Common - cell divisionFtsK/SpoIIIE Francci3_3398 7 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 86742523 Nonpathogen - NAD-dependent epimerase/dehydratase Francci3_3844 11 COG1090 COG1090, Predicted nucleoside-diphosphate sugar epimerase General function prediction only 86740539 Nonpathogen - hypothetical protein Francci3_1834 1 None None None 86738905 Common - hypothetical protein Francci3_0184 5 None None None 86739862 Common - MscS Mechanosensitive ion channel Francci3_1154 150 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 86742833 Nonpathogen - hypothetical protein Francci3_4156 1 None None None 86738742 Common - hypothetical protein Francci3_0019 7 None None None 86739240 Common - phosphoadenosine phosphosulfate reductase Francci3_0527 163 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 86739836 Nonpathogen - Lantibiotic dehydratase-like Francci3_1127 6 None None None 86742754 Common - protein of unknown function DUF574 Francci3_4077 12 None None None 86741426 Nonpathogen - hypothetical protein Francci3_2737 1 None None None 86742199 Common - hypothetical protein Francci3_3517 7 None None None 86741605 Common - von Willebrand factor, type A Francci3_2918 16 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 86741613 Common - Carbamoyl-phosphate synthase L chain, ATP-binding Francci3_2926 228 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 86739888 Common - exodeoxyribonuclease III Francci3_1180 196 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 86741764 Nonpathogen - hypothetical protein Francci3_3078 2 COG3889 COG3889, Predicted solute binding protein General function prediction only 86739381 Nonpathogen - hypothetical protein Francci3_0668 1 None None None 86740341 Common - protein of unknown function DUF199 Francci3_1636 45 COG1481 COG1481, Uncharacterized protein conserved in bacteria Function unknown 86741121 Common - protein serine/threonine phosphatases Francci3_2425 47 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 86741673 Common - transcriptional regulator, SARP family Francci3_2987 18 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 86742341 Common - putative transcriptional regulator Francci3_3660 7 None None None 86742149 Common sdhA succinate dehydrogenase flavoprotein subunit Francci3_3466 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 86741366 Common - hypothetical protein Francci3_2675 22 None None None 86742801 Common - Recombinase Francci3_4124 18 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 86741221 Common - NAD-dependent epimerase/dehydratase Francci3_2527 20 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 86739945 Nonpathogen - hypothetical protein Francci3_1238 1 None None None 86740695 Common - 2OG-Fe(II) oxygenase Francci3_1992 53 COG3491 PcbC, Isopenicillin N synthase and related dioxygenases General function prediction only 86739848 Common - hypothetical protein Francci3_1140 4 None None None 86740127 Common - protein of unknown function DUF552 Francci3_1421 53 COG1799 COG1799, Uncharacterized protein conserved in bacteria Function unknown 86738799 Common - ErfK/YbiS/YcfS/YnhG Francci3_0076 72 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 86742663 Common - TOBE Francci3_3984 17 COG3585 MopI, Molybdopterin-binding protein Coenzyme metabolism 86742281 Common - formamidopyrimidine-DNA glycosylase Francci3_3600 179 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 86739203 Common - delta-aminolevulinic acid dehydratase Francci3_0488 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 86739402 Common upp uracil phosphoribosyltransferase Francci3_0689 164 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 86739291 Common - 30S ribosomal protein S7 Francci3_0578 238 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 86739331 Nonpathogen - zinc finger, SWIM-type Francci3_0618 1 COG4715 COG4715, Uncharacterized conserved protein Function unknown 86740683 Common - hypothetical protein Francci3_1980 39 COG4325 COG4325, Predicted membrane protein Function unknown 86742005 Nonpathogen - acetyl/acyl transferase related protein Francci3_3319 6 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 86742041 Common - Radical SAM Francci3_3357 17 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 86739960 Common - putative integral membrane protein Francci3_1253 9 None None None 86738779 Common - dehydrogenase subunit Francci3_0056 194 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 86738764 Common - NLP/P60 Francci3_0041 146 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 86739503 Nonpathogen - hypothetical protein Francci3_0790 1 None None None 86742571 Nonpathogen - hypothetical protein Francci3_3892 1 None None None 86739951 Common - Drug resistance transporter EmrB/QacA subfamily Francci3_1244 194 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86741204 Common - putative acetone carboxylase gamma subunit Francci3_2508 16 COG4647 AcxC, Acetone carboxylase, gamma subunit Secondary metabolites biosynthesis, transport, and catabolism 86740478 Common - UbiE/COQ5 methyltransferase Francci3_1773 185 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86742015 Nonpathogen - hypothetical protein Francci3_3329 1 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 86742537 Common - 4Fe-4S ferredoxin, iron-sulfur binding Francci3_3858 143 COG1146 COG1146, Ferredoxin Energy production and conversion 86738983 Nonpathogen - hypothetical protein Francci3_0266 1 None None None 86743152 Common - HesB/YadR/YfhF Francci3_4477 185 COG0316 IscA, Uncharacterized conserved protein Function unknown 86739742 Common - hypothetical protein Francci3_1030 4 None None None 86743145 Common - response regulator receiver protein Francci3_4470 153 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 86739073 Common - OmpA/MotB Francci3_0357 80 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 86739712 Common - 3-hydroxyacyl-CoA dehydrogenase Francci3_1000 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 86740907 Common - molydopterin dinucleotide-binding region Francci3_2209 71 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 86741729 Nonpathogen - hypothetical protein Francci3_3043 1 None None None 86743034 Common - hypothetical protein Francci3_4359 14 None None None 86739268 Common - pyruvate flavodoxin/ferredoxin oxidoreductase-like Francci3_0555 106 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 86739764 Common - GDP-mannose 4,6-dehydratase Francci3_1053 216 COG1089 Gmd, GDP-D-mannose dehydratase Cell envelope biogenesis, outer membrane 86740974 Common - Alcohol dehydrogenase, zinc-binding Francci3_2277 76 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 86742653 Common - protein of unknown function DUF305 Francci3_3974 28 COG3544 COG3544, Uncharacterized protein conserved in bacteria Function unknown 86738828 Nonpathogen - hypothetical protein Francci3_0105 5 None None None 86740617 Nonpathogen - hypothetical protein Francci3_1912 4 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 86739936 Common - AAA_5 ATPase associated with various cellular activities Francci3_1229 97 COG0714 COG0714, MoxR-like ATPases General function prediction only 86741044 Common - hypothetical protein Francci3_2348 2 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 86742391 Common - ATP synthase F1, delta subunit Francci3_3710 18 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 86739045 Nonpathogen - hypothetical protein Francci3_0329 1 None None None 86741138 Common - hypothetical protein Francci3_2442 6 None None None 86741635 Common - NAD(P) transhydrogenase, beta subunit Francci3_2948 123 COG1282 PntB, NAD/NADP transhydrogenase beta subunit Energy production and conversion 86742467 Common - UBA/THIF-type NAD/FAD binding fold Francci3_3787 7 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 86740499 Nonpathogen - hypothetical protein Francci3_1794 1 None None None 86742588 Nonpathogen - hypothetical protein Francci3_3909 3 None None None 86739316 Common - adenylate kinases Francci3_0603 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 86743061 Common - protein serine/threonine phosphatases Francci3_4386 90 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 86741358 Common - Methenyltetrahydrofolate cyclohydrolase Francci3_2667 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 86742025 Common - hypothetical protein Francci3_3339 6 None None None 86741286 Common - Radical SAM Francci3_2595 89 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 86742386 Nonpathogen - transcriptional modulator of MazE/toxin, MazF Francci3_3705 2 COG2337 MazF, Growth inhibitor Signal transduction mechanisms 86738842 Nonpathogen - putative signal transduction protein with Nacht domain Francci3_0119 1 COG5635 COG5635, Predicted NTPase (NACHT family) Signal transduction mechanisms 86742426 Common - hypothetical protein Francci3_3746 64 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 86740516 Common - NUDIX hydrolase Francci3_1811 53 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 86741407 Common - transcriptional regulator, ArsR family Francci3_2717 48 COG0640 ArsR, Predicted transcriptional regulators Transcription 86743007 Common - protein of unknown function DUF742 Francci3_4332 8 None None None 86743100 Common - serine/threonine protein kinase Francci3_4425 145 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86739376 Common - ribonuclease BN Francci3_0663 24 COG1295 Rbn, Predicted membrane protein Function unknown 86740271 Common - putative sugar nucleotide processing enzyme Francci3_1566 41 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86740338 Common uvrC excinuclease ABC subunit C Francci3_1633 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 86740461 Common - sulfatase Francci3_1756 11 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 86738726 Common - DNA polymerase III, beta subunit Francci3_0003 201 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 86743042 Common - hypothetical protein Francci3_4367 14 None None None 86743185 Common - hypothetical protein Francci3_4510 4 None None None 86741490 Common - General substrate transporter Francci3_2803 127 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86741471 Nonpathogen - hypothetical protein Francci3_2783 3 None None None 86743109 Common - Peptidoglycan glycosyltransferase Francci3_4434 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 86738959 Common - ABC transporter related Francci3_0241 248 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 86741901 Nonpathogen - putative secreted protein Francci3_3215 1 None None None 86739311 Common rplR 50S ribosomal protein L18 Francci3_0598 216 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 86740824 Nonpathogen - putative IS493-like transposase Francci3_2123 3 None None None 86742597 Common - NADH dehydrogenase Francci3_3918 199 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 86741272 Common - globin Francci3_2581 40 COG2346 COG2346, Truncated hemoglobins General function prediction only 86740147 Nonpathogen - hypothetical protein Francci3_1441 1 None None None 86741046 Common - Phosphoglycerate mutase Francci3_2350 32 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 86738952 Common - two component transcriptional regulator, winged helix family Francci3_0234 212 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86742186 Common - acetyl-CoA synthetase Francci3_3504 191 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 86742133 Nonpathogen - hypothetical protein Francci3_3450 1 None None None 86742931 Nonpathogen - hypothetical protein Francci3_4256 1 None None None 86740418 Nonpathogen - hypothetical protein Francci3_1713 1 None None None 86741711 Common - Imidazoleglycerol-phosphate dehydratase Francci3_3025 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 86741821 Common - dehydrogenase subunit Francci3_3135 194 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 86742371 Common - Crotonyl-CoA reductase Francci3_3690 173 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 86739109 Common - Recombinase Francci3_0393 48 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 86740166 Common - peptidase C60, sortase A and B Francci3_1460 13 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 86741299 Nonpathogen - hypothetical protein Francci3_2608 1 None None None 86741243 Nonpathogen - hypothetical protein Francci3_2550 2 None None None 86739293 Common - elongation factor Tu Francci3_0580 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 86741965 Common - hypothetical protein Francci3_3279 15 None None None 86739843 Common - NUDIX hydrolase Francci3_1135 137 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 86739634 Common - chaperonin Cpn10 Francci3_0921 40 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 86741292 Common - putative ABC transporter permease Francci3_2601 32 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 86741720 Common - hypothetical protein Francci3_3034 2 None None None 86742043 Common - Drug resistance transporter EmrB/QacA subfamily Francci3_3359 174 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86739971 Common hrcA heat-inducible transcription repressor Francci3_1264 151 COG1420 HrcA, Transcriptional regulator of heat shock gene Transcription 86738926 Common - transcriptional regulator, XRE family Francci3_0208 41 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 86743122 Nonpathogen - hypothetical protein Francci3_4447 1 None None None 86740321 Nonpathogen - hypothetical protein Francci3_1616 1 None None None 86742398 Common - Glycine hydroxymethyltransferase Francci3_3717 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 86742622 Common - putative acyl carrier protein Francci3_3943 11 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86738935 Common - RNA binding S1 Francci3_0217 206 COG2183 Tex, Transcriptional accessory protein Transcription 86742664 Common - Molybdate ABC transporter, permease protein Francci3_3985 182 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 86739994 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Francci3_1288 177 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 86740183 Nonpathogen - hypothetical protein Francci3_1477 1 None None None 86740215 Nonpathogen - hypothetical protein Francci3_1510 2 None None None 86741742 Common - protein of unknown function UPF0047 Francci3_3056 64 COG0432 COG0432, Uncharacterized conserved protein Function unknown 86740802 Nonpathogen - hypothetical protein Francci3_2101 1 None None None 86740066 Common - histidine triad (HIT) protein Francci3_1360 110 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 86743107 Common - protein serine/threonine phosphatases Francci3_4432 127 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 86742569 Nonpathogen - hypothetical protein Francci3_3890 1 None None None 86739145 Common - DegT/DnrJ/EryC1/StrS aminotransferase Francci3_0429 192 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 86741445 Common - tryptophan halogenase Francci3_2756 57 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 86738758 Common - putative integral membrane protein Francci3_0035 7 None None None 86738825 Common - hypothetical protein Francci3_0102 9 None None None 86739404 Common - purine nucleoside phosphorylase Francci3_0691 111 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 86739228 Common - Carboxylyase-related protein Francci3_0515 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 86739881 Common mdoC glucans biosynthesis protein Francci3_1173 12 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 86743003 Nonpathogen - hypothetical protein Francci3_4328 1 None None None 86740715 Common - transcriptional regulator, IclR family Francci3_2012 7 COG1414 IclR, Transcriptional regulator Transcription 86742913 Common - major facilitator superfamily MFS_1 Francci3_4238 20 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86739790 Common - hydrogenase accessory protein HypB Francci3_1079 129 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 86742113 Common - putative transposase, IS891/IS1136/IS1341 Francci3_3430 70 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 86743000 Nonpathogen - hypothetical protein Francci3_4325 1 COG5373 COG5373, Predicted membrane protein Function unknown 86742866 Common - putative transposase Francci3_4189 42 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742206 Common recX recombination regulator RecX Francci3_3524 25 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 86741036 Common - hypothetical protein Francci3_2339 3 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 86742274 Common - hypothetical protein Francci3_3593 18 COG1837 COG1837, Predicted RNA-binding protein (contains KH domain) General function prediction only 86739826 Nonpathogen - hypothetical protein Francci3_1117 3 None None None 86739828 Common - transposase, IS4 Francci3_1119 30 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86740577 Common - putative IS630 family transposase Francci3_1872 45 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 86738931 Common - Rieske (2Fe-2S) protein Francci3_0213 54 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 86739284 Common rplJ 50S ribosomal protein L10 Francci3_0571 208 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 86739464 Common manB phosphomannomutase/phosphoglucomutase Francci3_0751 240 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 86742316 Common - 2-isopropylmalate synthase Francci3_3635 209 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 86738900 Common - putative acetyltransferase Francci3_0179 26 None None None 86740381 Common - ABC transporter related Francci3_1676 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 86739821 Common - aspartate 1-decarboxylase Francci3_1112 130 COG0853 PanD, Aspartate 1-decarboxylase Coenzyme metabolism 86740042 Common - Chlorite dismutase Francci3_1336 38 COG3253 COG3253, Uncharacterized conserved protein Function unknown 86739721 Common - protein tyrosine phosphatase Francci3_1009 101 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 86739787 Common - Hydrogen:quinone oxidoreductase Francci3_1076 92 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 86742166 Common - beta-ketoacyl synthase Francci3_3484 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86740861 Nonpathogen - Methylase involved in ubiquinone/menaquinone biosynthesis-like Francci3_2162 1 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86742505 Common - PHP-like Francci3_3826 114 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 86741769 Nonpathogen - hypothetical protein Francci3_3083 1 COG5421 COG5421, Transposase DNA replication, recombination, and repair 86740118 Common mraY phospho-N-acetylmuramoyl-pentapeptide-transferase Francci3_1412 216 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 86742431 Common - malate dehydrogenase Francci3_3751 189 COG0281 SfcA, Malic enzyme Energy production and conversion 86742853 Nonpathogen - hypothetical protein Francci3_4176 2 None None None 86739363 Common - serine/threonine protein kinase Francci3_0650 132 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86742110 Common - hypothetical protein Francci3_3427 15 COG2378 COG2378, Predicted transcriptional regulator Transcription 86739252 Common - NADH dehydrogenase subunit B Francci3_0539 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 86741084 Nonpathogen - hypothetical protein Francci3_2388 1 None None None 86739447 Common - glycosyl transferase, group 1 Francci3_0734 124 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86739440 Common - serine/threonine protein kinase with WD40 repeats Francci3_0727 164 COG2319 COG2319, FOG: WD40 repeat General function prediction only 86739526 Nonpathogen - protein of unknown function DUF214 Francci3_0813 6 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 86739972 Common - Chaperone DnaJ Francci3_1265 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 86740224 Common - nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin-like Francci3_1519 11 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 86741927 Common - hypothetical protein Francci3_3241 9 None None None 86740992 Common - Lignostilbene-alpha beta-dioxygenase and related enzymes-like Francci3_2295 5 COG3670 COG3670, Lignostilbene-alpha,beta-dioxygenase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 86741056 Common - hypothetical protein Francci3_2360 7 None None None 86742319 Common - ketol-acid reductoisomerase Francci3_3638 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 86742936 Common - two component transcriptional regulator, winged helix family Francci3_4261 177 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86740155 Common - Alcohol dehydrogenase, zinc-binding Francci3_1449 192 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 86741993 Common - zinc finger, CHC2-type Francci3_3307 45 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 86739753 Common - Endopeptidase La Francci3_1042 208 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 86742786 Common - PilT protein-like Francci3_4109 18 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 86743028 Common - GrpE protein Francci3_4353 75 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 86740427 Nonpathogen - hypothetical protein Francci3_1722 1 None None None 86741304 Common - hypothetical protein Francci3_2613 7 None None None 86739126 Nonpathogen - hypothetical protein Francci3_0410 2 None None None 86742266 Common - Mg chelatase-related protein Francci3_3585 187 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 86740946 Common - hypothetical protein Francci3_2249 8 None None None 86741062 Common - hypothetical protein Francci3_2366 12 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 86739642 Common - alpha/beta hydrolase fold Francci3_0929 17 COG2267 PldB, Lysophospholipase Lipid metabolism 86740160 Common - Pseudouridine synthase, Rsu Francci3_1454 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 86741959 Common - Cupin 2 Francci3_3273 221 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86741097 Common - two component transcriptional regulator, winged helix family Francci3_2401 212 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86742227 Common - putative phosphoketolase Francci3_3546 65 COG3957 COG3957, Phosphoketolase Carbohydrate transport and metabolism 86740098 Common - FAD dependent oxidoreductase Francci3_1392 66 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 86741661 Common - Allophanate hydrolase Francci3_2975 115 COG1984 DUR1, Allophanate hydrolase subunit 2 Amino acid transport and metabolism 86739568 Common - inner-membrane translocator Francci3_0855 35 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 86739801 Common - Death-on-curing protein Francci3_1091 58 COG3654 Doc, Prophage maintenance system killer protein General function prediction only 86741157 Common - Amino acid adenylation Francci3_2461 208 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 86740285 Common - glycosyl transferase, family 2 Francci3_1580 124 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 86740350 Common - 6-phosphogluconolactonase Francci3_1645 108 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 86741071 Nonpathogen - hypothetical protein Francci3_2375 1 None None None 86740776 Nonpathogen - hypothetical protein Francci3_2074 1 None None None 86742490 Common - Antibiotic biosynthesis monooxygenase Francci3_3811 20 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 86741393 Common - protein of unknown function DUF397 Francci3_2703 5 None None None 86739582 Common - Ham1-like protein Francci3_0869 237 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 86742971 Common - putative septum site determining protein Francci3_4296 12 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 86740983 Nonpathogen - hypothetical protein Francci3_2286 1 None None None 86740132 Common - Pseudouridine synthase, RluD Francci3_1426 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 86741324 Common - peptidase M50 Francci3_2633 29 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 86739357 Common - periplasmic sensor signal transduction histidine kinase Francci3_0644 58 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 86743128 Common - exporters of the RND superfamily-like Francci3_4453 34 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 86740434 Common - putative transcriptional regulator Francci3_1729 5 COG1733 COG1733, Predicted transcriptional regulators Transcription 86739432 Nonpathogen - hypothetical protein Francci3_0719 1 None None None 86743062 Nonpathogen - putative integral membrane protein Francci3_4387 5 None None None 86739350 Common - inositol-5-monophosphate dehydrogenase Francci3_0637 72 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 86739952 Nonpathogen - hypothetical protein Francci3_1245 12 None None None 86741380 Nonpathogen - hypothetical protein Francci3_2690 4 None None None 86739583 Common rph ribonuclease PH Francci3_0870 184 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 86741455 Common - binding-protein-dependent transport systems inner membrane component Francci3_2766 215 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 86741388 Common - hypothetical protein Francci3_2698 6 None None None 86740034 Nonpathogen - hypothetical protein Francci3_1328 1 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 86739135 Nonpathogen - Integrase Francci3_0419 7 None None None 86740855 Common - periplasmic sensor signal transduction histidine kinase Francci3_2154 221 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 86739561 Common - agmatinase, putative Francci3_0848 144 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 86740746 Common - 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases-like Francci3_2043 27 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 86738919 Common - secretion protein HlyD Francci3_0200 88 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 86738816 Common - hypothetical protein Francci3_0093 18 None None None 86738870 Common - methylated-DNA--protein-cysteine methyltransferase Francci3_0147 207 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 86740091 Common - protein of unknown function DUF58 Francci3_1385 59 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 86739165 Common - protein of unknown function DUF1416 Francci3_0450 10 None None None 86742117 Nonpathogen - hypothetical protein Francci3_3434 2 None None None 86740818 Common - binding-protein-dependent transport systems inner membrane component Francci3_2117 201 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 86741668 Common - acyl-CoA synthetase Francci3_2982 220 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86741692 Common - Methylmalonyl-CoA mutase Francci3_3006 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 86741438 Nonpathogen - hypothetical protein Francci3_2749 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 86742658 Common - Drug resistance transporter EmrB/QacA subfamily Francci3_3979 188 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 86741625 Nonpathogen - hypothetical protein Francci3_2938 3 COG5500 COG5500, Predicted integral membrane protein Function unknown 86740052 Common - AFG1-like ATPase Francci3_1346 13 COG1485 COG1485, Predicted ATPase General function prediction only 86742954 Common - Anion-transporting ATPase Francci3_4279 50 COG0003 ArsA, Predicted ATPase involved in chromosome partitioning Cell division and chromosome partitioning 86741015 Common - RNA-directed DNA polymerase Francci3_2318 94 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 86739012 Common - insertion element conserved hypothetical protein Francci3_0296 16 None None None 86742101 Common - sporulation and cell division protein SsgA Francci3_3418 8 None None None 86741194 Common - Twin-arginine translocation pathway signal Francci3_2498 36 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 86739185 Common - histidine kinase Francci3_0470 220 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 86740881 Nonpathogen - hypothetical protein Francci3_2182 1 None None None 86741329 Nonpathogen - hypothetical protein Francci3_2638 1 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 86739556 Common - hypothetical protein Francci3_0843 9 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 86740443 Nonpathogen - hypothetical protein Francci3_1738 4 COG1261 FlgA, Flagellar basal body P-ring biosynthesis protein Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 86741699 Common - Glutamate synthase (ferredoxin) Francci3_3013 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 86741317 Common - 20S proteasome, A and B subunits Francci3_2626 15 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 86739370 Common purH bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Francci3_0657 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 86741364 Common - serine/threonine protein kinase Francci3_2673 148 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86741175 Common - periplasmic solute binding protein Francci3_2479 114 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 86743056 Common - hypothetical protein Francci3_4381 9 None None None 86742773 Common - putative IS6 family transposase Francci3_4096 42 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740811 Common - major facilitator superfamily MFS_1 Francci3_2110 86 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86739005 Nonpathogen - hypothetical protein Francci3_0289 1 None None None 86742946 Common - hypothetical protein Francci3_4271 2 None None None 86738897 Nonpathogen - hypothetical protein Francci3_0176 1 None None None 86741952 Common - putative transposase, IS891/IS1136/IS1341 Francci3_3266 70 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742327 Common - amino acid-binding ACT Francci3_3646 9 None None None 86739599 Common - hypothetical protein Francci3_0886 10 None None None 86741462 Common - ATP-dependent Clp protease proteolytic subunit Francci3_2773 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 86739987 Nonpathogen - hypothetical protein Francci3_1280 1 None None None 86741182 Common - branched-chain alpha-keto acid dehydrogenase subunit E2 Francci3_2486 194 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 86741001 Common - phage integrase Francci3_2304 43 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86740388 Common - hypothetical protein Francci3_1683 33 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 86741523 Common - metallophosphoesterase Francci3_2836 92 COG1409 Icc, Predicted phosphohydrolases General function prediction only 86740599 Common - enoyl-(acyl carrier protein) reductase Francci3_1894 213 COG0623 FabI, Enoyl- acyl-carrier-protein 86739676 Nonpathogen - hypothetical protein Francci3_0963 1 None None None 86738888 Common - sigma-24 Francci3_0167 57 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 86739158 Common - response regulator receiver protein Francci3_0443 184 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86742896 Common - transposase, IS4 Francci3_4220 28 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86740896 Common - hypothetical protein Francci3_2198 2 None None None 86740000 Common - NAD-dependent epimerase/dehydratase Francci3_1294 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 86741372 Common - transposase, IS605 OrfB Francci3_2681 70 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742791 Nonpathogen - hypothetical protein Francci3_4114 1 None None None 86742171 Nonpathogen - hypothetical protein Francci3_3489 1 None None None 86738976 Common - CHAD Francci3_0259 61 COG5607 COG5607, Uncharacterized conserved protein Function unknown 86743139 Common - cytochrome P450 Francci3_4464 81 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 86740842 Nonpathogen - hypothetical protein Francci3_2141 1 None None None 86740870 Common - heat shock protein DnaJ-like Francci3_2171 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 86739605 Common - hypothetical protein Francci3_0892 5 None None None 86742768 Nonpathogen - hypothetical protein Francci3_4091 1 None None None 86743171 Common - nickel-dependent hydrogenase, large subunit Francci3_4496 93 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 86739192 Nonpathogen - Protein of unknown function DUF1713 Francci3_0477 1 None None None 86739390 Common - ATP-dependent DNA helicase, RecQ family Francci3_0677 229 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 86739475 Common - putative integral membrane protein Francci3_0762 9 None None None 86742823 Common - short-chain dehydrogenase/reductase SDR Francci3_4146 236 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 86741400 Nonpathogen - hypothetical protein Francci3_2710 5 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 86742178 Common - cell envelope-related transcriptional attenuator Francci3_3496 61 COG1316 LytR, Transcriptional regulator Transcription 86741874 Common - Ribulose-phosphate 3-epimerase Francci3_3188 214 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 86739620 Nonpathogen - hypothetical protein Francci3_0907 1 None None None 86741064 Common - zinc/iron permease Francci3_2368 32 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 86742574 Common - peptide methionine sulfoxide reductase Francci3_3895 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 86739418 Nonpathogen - hypothetical protein Francci3_0705 1 None None None 86740420 Nonpathogen - hypothetical protein Francci3_1715 1 None None None 86739426 Common - glucose-1-phosphate thymidyltransferase Francci3_0713 235 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 86742557 Nonpathogen - hypothetical protein Francci3_3878 1 None None None 86741807 Common - HesB/YadR/YfhF Francci3_3121 166 COG0316 IscA, Uncharacterized conserved protein Function unknown 86739876 Nonpathogen - hypothetical protein Francci3_1168 1 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 86743079 Common - hypothetical protein Francci3_4404 11 None None None 86739261 Common - NADH dehydrogenase subunit K Francci3_0548 159 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 86741078 Common - adenosine/AMP deaminase Francci3_2382 93 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 86742683 Common - major facilitator superfamily MFS_1 Francci3_4004 158 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86740344 Common tpiA triosephosphate isomerase Francci3_1639 215 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 86741419 Nonpathogen - hypothetical protein Francci3_2730 1 None None None 86742742 Common - diguanylate cyclase (GGDEF domain) Francci3_4063 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 86740680 Nonpathogen - hypothetical protein Francci3_1977 9 None None None 86739174 Nonpathogen - hypothetical protein Francci3_0459 1 None None None 86740402 Common - transcriptional regulator, XRE family Francci3_1697 7 COG1396 HipB, Predicted transcriptional regulators Transcription 86739269 Common - hypothetical protein Francci3_0556 27 COG5495 COG5495, Uncharacterized conserved protein Function unknown 86742144 Common - response regulator receiver protein Francci3_3461 203 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 86741414 Nonpathogen - hypothetical protein Francci3_2725 1 None None None 86739399 Common - adenosine deaminase Francci3_0686 100 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 86740202 Nonpathogen - hypothetical protein Francci3_1497 1 COG2839 COG2839, Uncharacterized protein conserved in bacteria Function unknown 86739168 Nonpathogen - hypothetical protein Francci3_0453 1 None None None 86741197 Common - Cl- channel, voltage gated Francci3_2501 160 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 86739048 Common - metallophosphoesterase Francci3_0332 14 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 86739233 Nonpathogen - hypothetical protein Francci3_0520 1 None None None 86741755 Common - hypothetical protein Francci3_3069 2 None None None 86740676 Common - ErfK/YbiS/YcfS/YnhG Francci3_1973 53 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 86740268 Common - Nucleotidyl transferase Francci3_1563 145 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 86742152 Common - D-amino-acid dehydrogenase Francci3_3470 117 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 86742126 Common - protein of unknown function DUF336 Francci3_3443 13 COG3193 GlcG, Uncharacterized protein, possibly involved in utilization of glycolate and propanediol General function prediction only 86740655 Common - Tetratricopeptide TPR_4 Francci3_1951 29 None None None 86739573 Common - nicotinate phosphoribosyltransferase Francci3_0860 103 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 86742796 Nonpathogen - hypothetical protein Francci3_4119 2 None None None 86740590 Common - transcriptional regulator, MerR family Francci3_1885 66 COG0789 SoxR, Predicted transcriptional regulators Transcription 86741089 Common - hypothetical protein Francci3_2393 7 COG5485 COG5485, Predicted ester cyclase General function prediction only 86742543 Common - LmbE-like protein Francci3_3864 22 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 86741153 Common - Enoyl-CoA hydratase/isomerase Francci3_2457 39 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 86739066 Nonpathogen - hypothetical protein Francci3_0350 2 None None None 86740005 Common - Methyltransferase FkbM Francci3_1299 4 None None None 86743089 Common - NAD/FAD-dependent oxidoreductase-like Francci3_4414 23 COG3380 COG3380, Predicted NAD/FAD-dependent oxidoreductase General function prediction only 86740480 Common - Radical SAM Francci3_1775 67 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 86742434 Common - putative serine/threonine kinase anti-sigma factor Francci3_3754 11 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 86740011 Common - glycosyl transferase, family 4 Francci3_1305 96 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 86740075 Common ruvC Holliday junction resolvase Francci3_1369 192 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 86742011 Nonpathogen - hypothetical protein Francci3_3325 1 None None None 86742469 Common - transcription factor WhiB Francci3_3790 19 None None None 86738869 Common - short-chain dehydrogenase/reductase SDR Francci3_0146 236 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 86741163 Common - transposase, IS4 Francci3_2467 28 None None None 86739758 Common - Endopeptidase La Francci3_1047 180 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 86741785 Nonpathogen - hypothetical protein Francci3_3099 1 None None None 86739788 Common - hydrogenase (NiFe) small subunit (hydA) Francci3_1077 79 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 86739774 Common - Carnitine O-acetyltransferase Francci3_1063 7 None None None 86742184 Common - GCN5-related N-acetyltransferase Francci3_3502 145 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 86741300 Common - hypothetical protein Francci3_2609 27 COG2378 COG2378, Predicted transcriptional regulator Transcription 86742420 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Francci3_3740 178 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 86739499 Common - peptidase S15 Francci3_0786 18 COG2936 COG2936, Predicted acyl esterases General function prediction only 86740466 Common - DNA topoisomerase II Francci3_1761 237 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 86742376 Common - hypothetical protein Francci3_3695 37 COG1637 COG1637, Predicted nuclease of the RecB family DNA replication, recombination, and repair 86740209 Common - 4'-phosphopantetheinyl transferase Francci3_1504 33 COG2977 EntD, Phosphopantetheinyl transferase component of siderophore synthetase Secondary metabolites biosynthesis, transport, and catabolism 86742941 Nonpathogen - hypothetical protein Francci3_4266 1 None None None 86738965 Nonpathogen - transposase Francci3_0248 3 None None None 86742056 Nonpathogen - ribosomal RNA methyltransferase Francci3_3372 3 None None None 86738954 Common - modification methylase, HemK family Francci3_0236 231 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 86741758 Common - putative transcriptional regulatory protein Francci3_3072 15 None None None 86740572 Common - tryptophanyl-tRNA synthetase Francci3_1867 238 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86742503 Common - 4-aminobutyrate aminotransferase Francci3_3824 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 86742164 Common - 3-oxoacyl-(acyl carrier protein) synthase III Francci3_3482 203 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 86742237 Common rpsO 30S ribosomal protein S15 Francci3_3556 214 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 86741569 Common - transcriptional regulator, XRE family Francci3_2882 13 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 86739982 Common - Glycine--tRNA ligase Francci3_1275 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 86742964 Common - putative Endonuclease III Francci3_4289 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 86741351 Common - Peptide deformylase Francci3_2660 204 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 86740588 Common - DNA polymerase, beta-like region Francci3_1883 54 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 86739680 Common - hypothetical protein Francci3_0967 3 None None None 86739662 Common - hypothetical protein Francci3_0949 20 None None None 86742893 Nonpathogen - transposase, IS4 Francci3_4217 3 None None None 86739515 Common - hypothetical protein Francci3_0802 18 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 86742582 Common - LmbE-like protein Francci3_3903 36 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 86742661 Common - hypothetical protein Francci3_3982 7 None None None 86742729 Common - serine phosphatase Francci3_4050 46 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 86742720 Common - 5-formyltetrahydrofolate cyclo-ligase Francci3_4041 38 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 86738753 Common - secretory lipase Francci3_0030 17 COG2267 PldB, Lysophospholipase Lipid metabolism 86740521 Common - flavoprotein Francci3_1816 8 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 86739541 Common - transcriptional regulator, TetR family Francci3_0828 110 COG1309 AcrR, Transcriptional regulator Transcription 86741034 Common - acyltransferase 3 Francci3_2337 21 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 86740192 Common - two component transcriptional regulator, LuxR family Francci3_1487 203 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86739894 Common - hypothetical protein Francci3_1186 15 None None None 86740153 Common - putative transglycosylase associated protein Francci3_1447 10 None None None 86741945 Common - glycoside hydrolase, family 26 Francci3_3259 30 COG4124 ManB, Beta-mannanase Carbohydrate transport and metabolism 86740138 Common - peptidase S16, lon-like Francci3_1432 18 COG2802 COG2802, Uncharacterized protein, similar to the N-terminal domain of Lon protease General function prediction only 86740873 Common - heat shock protein Hsp20 Francci3_2174 151 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 86741930 Common - protein-L-isoaspartate(D-aspartate) O-methyltransferase Francci3_3244 154 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 86739510 Nonpathogen - hypothetical protein Francci3_0797 1 None None None 86741915 Common - Male sterility-like Francci3_3229 23 COG3320 COG3320, Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 86742911 Nonpathogen - hypothetical protein Francci3_4236 1 None None None 86743118 Common - Rhomboid-like protein Francci3_4443 96 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 86743080 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Francci3_4405 193 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 86740399 Common - Type IV secretory pathway VirD4 components-like Francci3_1694 18 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 86742849 Common - hypothetical protein Francci3_4172 14 None None None 86739929 Common obgE GTPase ObgE Francci3_1222 249 COG0536 Obg, Predicted GTPase General function prediction only 86742445 Common - biotin/lipoyl attachment Francci3_3765 16 COG1038 PycA, Pyruvate carboxylase Energy production and conversion 86743113 Common - protein of unknown function DUF881 Francci3_4438 25 COG3879 COG3879, Uncharacterized protein conserved in bacteria Function unknown 86742429 Common - conserved hypothetical protein 2SC7G11.29c Francci3_3749 8 None None None 86742323 Common gatB aspartyl/glutamyl-tRNA amidotransferase subunit B Francci3_3642 210 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 86739115 Nonpathogen - hypothetical protein Francci3_0399 1 None None None 86741778 Common - Glucokinase ROK Francci3_3092 167 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 86741537 Common - beta-ketoacyl synthase Francci3_2850 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86742212 Nonpathogen - hypothetical protein Francci3_3531 3 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 86739832 Nonpathogen - hypothetical protein Francci3_1123 4 None None None 86738790 Common - HNH endonuclease Francci3_0067 7 None None None 86742401 Common prfA peptide chain release factor 1 Francci3_3720 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 86740374 Common - dTDP-glucose 4,6-dehydratase Francci3_1669 231 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 86739328 Common - ribosomal protein S9 Francci3_0615 219 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 86742253 Common - GCN5-related N-acetyltransferase Francci3_3572 15 COG3393 COG3393, Predicted acetyltransferase General function prediction only 86741973 Common - potassium-transporting ATPase subunit A Francci3_3287 96 COG2060 KdpA, K+-transporting ATPase, A chain Inorganic ion transport and metabolism 86742608 Common - hypothetical protein Francci3_3929 9 COG4124 ManB, Beta-mannanase Carbohydrate transport and metabolism 86740555 Nonpathogen - hypothetical protein Francci3_1850 1 None None None 86741816 Common cobT nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Francci3_3130 118 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 86741186 Common - Rieske (2Fe-2S) protein Francci3_2490 33 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 86739218 Common - transposase IS66 Francci3_0505 39 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 86738797 Common - hypothetical protein Francci3_0074 5 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 86741309 Common - GCN5-related N-acetyltransferase Francci3_2618 11 COG3153 COG3153, Predicted acetyltransferase General function prediction only 86739031 Common - glutamine synthetase, catalytic region Francci3_0315 210 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 86741214 Nonpathogen - methane/phenol/toluene hydroxylase Francci3_2518 14 None None None 86743197 Common rpsF 30S ribosomal protein S6 Francci3_4522 196 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 86742408 Common - Arginine--tRNA ligase Francci3_3727 233 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86740722 Common - putative transcriptional regulator Francci3_2019 132 COG1733 COG1733, Predicted transcriptional regulators Transcription 86741132 Common - protein-L-isoaspartate(D-aspartate) O-methyltransferase Francci3_2436 151 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 86742838 Nonpathogen - hypothetical protein Francci3_4161 1 None None None 86740966 Nonpathogen - hypothetical protein Francci3_2269 1 None None None 86740081 Common - adenine phosphoribosyltransferase Francci3_1375 164 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 86742873 Nonpathogen - hypothetical protein Francci3_4196 3 None None None 86741506 Common - protein of unknown function DUF124 Francci3_2819 21 COG2013 COG2013, Uncharacterized conserved protein Function unknown 86742140 Common - Allergen V5/Tpx-1 related Francci3_3457 94 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 86741687 Nonpathogen - hypothetical protein Francci3_3001 1 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 86742473 Common - response regulator receiver and ANTAR domain protein Francci3_3794 2 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 86742528 Nonpathogen - hypothetical protein Francci3_3849 1 None None None 86740125 Common - protein of unknown function DUF152 Francci3_1419 160 COG1496 COG1496, Uncharacterized conserved protein Function unknown 86742812 Common - Methyltransferase type 11 Francci3_4135 54 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86742442 Common bioD dithiobiotin synthetase Francci3_3762 15 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 86741981 Common - 6-phosphogluconate dehydrogenase, NAD-binding Francci3_3295 58 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 86742396 Nonpathogen - hypothetical protein Francci3_3715 1 None None None 86739608 Common - putative DNA-binding protein Francci3_0895 7 None None None 86739024 Common - two component transcriptional regulator, winged helix family Francci3_0308 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86740311 Common - phosphopantetheine-binding Francci3_1606 20 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86741783 Common - AMP-dependent synthetase and ligase Francci3_3097 210 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 86738789 Nonpathogen - hypothetical protein Francci3_0066 1 None None None 86742217 Common - Ferritin and Dps Francci3_3536 101 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 86738774 Nonpathogen - hypothetical protein Francci3_0051 2 None None None 86742020 Nonpathogen - hypothetical protein Francci3_3334 1 None None None 86738727 Common recF recombination protein F Francci3_0004 129 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 86741102 Common - AMP-dependent synthetase and ligase Francci3_2406 214 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86742732 Common - Diaminopimelate decarboxylase Francci3_4053 205 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 86739937 Common - VWA containing CoxE-like Francci3_1230 44 COG3552 CoxE, Protein containing von Willebrand factor type A (vWA) domain General function prediction only 86740333 Common - Integral membrane protein TerC Francci3_1628 97 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 86742083 Common - Excisionase/Xis, DNA-binding Francci3_3400 6 None None None 86742625 Common - tyrosyl-tRNA synthetase Francci3_3946 216 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86741656 Common - alpha/beta hydrolase fold Francci3_2970 114 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86743094 Common - hypothetical protein Francci3_4419 10 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86742835 Common - transcriptional regulator, XRE family Francci3_4158 12 COG1396 HipB, Predicted transcriptional regulators Transcription 86740935 Common - putative acetone carboxylase gamma subunit Francci3_2238 21 COG4647 AcxC, Acetone carboxylase, gamma subunit Secondary metabolites biosynthesis, transport, and catabolism 86741562 Common - serine/threonine protein kinase Francci3_2875 137 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86741264 Nonpathogen - hypothetical protein Francci3_2573 2 None None None 86739040 Common - response regulator receiver protein Francci3_0324 26 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86739490 Common - hypothetical protein Francci3_0777 14 COG3743 COG3743, Uncharacterized conserved protein Function unknown 86740177 Common - transcriptional regulator, MerR family Francci3_1471 20 COG0789 SoxR, Predicted transcriptional regulators Transcription 86739483 Common - hypothetical protein Francci3_0770 6 None None None 86739918 Common - cell shape determining protein, MreB/Mrl family Francci3_1211 235 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 86741334 Common - phosphatidylinositol 3- and 4-kinase Francci3_2643 18 None None None 86738912 Common - N-6 DNA methylase Francci3_0192 157 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 86739477 Common - sigma 54 modulation protein/ribosomal protein S30EA Francci3_0764 19 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 86741863 Common - phenylalanyl-tRNA synthetase, alpha subunit Francci3_3177 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 86739208 Common - hypothetical protein Francci3_0494 7 None None None 86741603 Common - hypothetical protein Francci3_2916 12 COG5650 COG5650, Predicted integral membrane protein Function unknown 86742924 Nonpathogen - hypothetical protein Francci3_4249 2 None None None 86742631 Common - ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5 Francci3_3952 122 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 86742065 Common - 6-pyruvoyl tetrahydropterin synthase and hypothetical protein Francci3_3381 128 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 86742714 Nonpathogen - hypothetical protein Francci3_4035 4 None None None 86741118 Common - putative secreted protein Francci3_2422 5 None None None 86741252 Common - NAD(P)H dehydrogenase (quinone) Francci3_2561 100 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 86738960 Common - heat shock protein 90 Francci3_0243 151 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 86739245 Nonpathogen - hypothetical protein Francci3_0532 1 None None None 86741615 Common - acetyl-CoA carboxylase, carboxyl transferase, beta subunit Francci3_2928 219 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 86741189 Common - Cytochrome-c oxidase Francci3_2493 173 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 86739706 Common - hypothetical protein Francci3_0994 18 None None None 86741048 Nonpathogen - hypothetical protein Francci3_2352 1 None None None 86740550 Nonpathogen - Endonuclease/exonuclease/phosphatase Francci3_1845 1 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 86741766 Common - hypothetical protein Francci3_3080 15 None None None 86740506 Common - aldo/keto reductase Francci3_1801 179 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 86742857 Common - PAS/PAC sensor hybrid histidine kinase Francci3_4180 220 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 86741671 Common - hypothetical protein Francci3_2985 4 None None None 86742147 Common - transcriptional regulator, LysR family Francci3_3464 191 COG0583 LysR, Transcriptional regulator Transcription 86739014 Common - GCN5-related N-acetyltransferase Francci3_0298 53 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 86743147 Common - 4Fe-4S ferredoxin, iron-sulfur binding Francci3_4472 153 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 86740809 Nonpathogen - hypothetical protein Francci3_2108 1 None None None 86743044 Nonpathogen - hypothetical protein Francci3_4369 1 None None None 86739026 Nonpathogen - hypothetical protein Francci3_0310 1 None None None 86740170 Common - protein of unknown function DUF881 Francci3_1464 25 COG3879 COG3879, Uncharacterized protein conserved in bacteria Function unknown 86741004 Common - hypothetical protein Francci3_2307 2 COG2261 COG2261, Predicted membrane protein Function unknown 86741889 Common - pyrimidine regulatory protein PyrR Francci3_3203 112 COG2065 PyrR, Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase Nucleotide transport and metabolism 86742756 Nonpathogen - hypothetical protein Francci3_4079 1 None None None 86742106 Common - Enoyl-CoA hydratase/isomerase Francci3_3423 135 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 86742007 Nonpathogen - hypothetical protein Francci3_3321 3 None None None 86741961 Common - L-lysine 6-monooxygenase (NADPH) Francci3_3275 52 COG3486 IucD, Lysine/ornithine N-monooxygenase Secondary metabolites biosynthesis, transport, and catabolism 86740782 Nonpathogen - hypothetical protein Francci3_2081 2 None None None 86740625 Common - heat shock protein Hsp20 Francci3_1920 155 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 86741428 Common - hypothetical protein Francci3_2739 3 None None None 86738766 Common - Twin-arginine translocation pathway signal Francci3_0043 45 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 86740291 Common - glycosyl transferase, family 2 Francci3_1586 25 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 86740846 Nonpathogen - hypothetical protein Francci3_2145 1 None None None 86741584 Common - small multidrug resistance protein Francci3_2897 88 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 86741223 Common - Recombinase Francci3_2529 39 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 86738855 Common - hypothetical protein Francci3_0132 5 None None None 86740685 Common - hypothetical protein Francci3_1982 5 None None None 86739860 Common - NmrA-like Francci3_1152 78 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 86740107 Common - Methyltransferase type 11 Francci3_1401 29 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86741420 Common - Alcohol dehydrogenase GroES-like Francci3_2731 168 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 86739360 Common - ATP-dependent DNA helicase PcrA Francci3_0647 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 86742284 Nonpathogen - ribosomal protein L32 Francci3_3603 2 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 86741008 Common - protein of unknown function DUF323 Francci3_2311 92 COG1262 COG1262, Uncharacterized conserved protein Function unknown 86739282 Common - ribosomal protein L11 Francci3_0569 248 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 86739470 Common - extracellular solute-binding protein, family 3 Francci3_0757 101 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 86741208 Common - putative metal cation transporter Francci3_2512 40 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 86740831 Common - transposase, IS4 Francci3_2130 16 None None None 86742539 Common - hypothetical protein Francci3_3860 38 COG2912 COG2912, Uncharacterized conserved protein Function unknown 86741340 Common - hypothetical protein Francci3_2649 40 COG1232 HemY, Protoporphyrinogen oxidase Coenzyme metabolism 86741206 Common - putative transcriptional regulator, Fis family Francci3_2510 118 COG3284 AcoR, Transcriptional activator of acetoin/glycerol metabolism Secondary metabolites biosynthesis, transport, and catabolism / Transcription 86742078 Common - serine/threonine protein kinase with WD40 repeats Francci3_3395 150 COG2319 COG2319, FOG: WD40 repeat General function prediction only 86741709 Common - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase Francci3_3023 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 86741013 Common - protein of unknown function DUF664 Francci3_2316 13 None None None 86739190 Common - acyltransferase 3 Francci3_0475 96 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 86739505 Common - polysaccharide deacetylase Francci3_0792 61 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 86740275 Common - polysaccharide biosynthesis protein Francci3_1570 71 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 86741855 Common - argininosuccinate synthase Francci3_3169 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 86740270 Common - Methyltransferase type 12 Francci3_1565 42 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 86738836 Nonpathogen - hypothetical protein Francci3_0113 1 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 86739201 Common - porphobilinogen deaminase Francci3_0486 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 86739309 Common rpsH 30S ribosomal protein S8 Francci3_0596 243 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 86742092 Nonpathogen - hypothetical protein Francci3_3409 1 None None None 86743159 Common - nitrogenase molybdenum-iron cofactor biosynthesis protein NifN Francci3_4484 48 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 86741225 Common - response regulator receiver protein Francci3_2531 8 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86742686 Nonpathogen - hypothetical protein Francci3_4007 1 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86741898 Common - aminodeoxychorismate lyase Francci3_3212 185 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 86740307 Common - AMP-dependent synthetase and ligase Francci3_1602 204 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86739958 Common - Alkane-1 monooxygenase Francci3_1251 26 None None None 86739967 Nonpathogen - hypothetical protein Francci3_1260 1 None None None 86741449 Common - UspA Francci3_2760 43 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 86743181 Common - hypothetical protein Francci3_4506 2 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742230 Common - UDP-glucose 6-dehydrogenase Francci3_3549 206 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 86742479 Common - UvrD/REP helicase Francci3_3800 209 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 86739367 Nonpathogen - hypothetical protein Francci3_0654 1 None None None 86741690 Common - arginine/ornithine transport system ATPase Francci3_3004 100 COG1703 ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family Amino acid transport and metabolism 86741888 Common pyrB aspartate carbamoyltransferase catalytic subunit Francci3_3202 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 86743136 Common - putative methyl-accepting chemotaxis sensory transducer Francci3_4461 12 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 86740392 Nonpathogen - hypothetical protein Francci3_1687 2 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 86740796 Common - putative 3-oxoacyl-ACP synthase III Francci3_2095 6 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 86740741 Common - hypothetical protein Francci3_2038 9 None None None 86738749 Nonpathogen - hypothetical protein Francci3_0026 1 None None None 86739148 Nonpathogen - ROK Francci3_0432 5 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 86742806 Nonpathogen - hypothetical protein Francci3_4129 1 None None None 86742414 Common - phage integrase-like SAM-like Francci3_3734 209 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86738990 Common - hypothetical protein Francci3_0274 6 None None None 86742069 Nonpathogen - hypothetical protein Francci3_3386 4 None None None 86741236 Common - Radical SAM Francci3_2543 136 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 86742032 Common - CRISPR-associated protein Cas1 Francci3_3346 98 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 86739353 Common - Twin-arginine translocation pathway signal Francci3_0640 11 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 86741146 Common - Amino acid adenylation Francci3_2450 218 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 86742224 Common - beta-lactamase-like Francci3_3543 166 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 86740248 Common - transcriptional regulator, LuxR family Francci3_1543 103 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86742027 Common - CRISPR-associated helicase Cas3, core Francci3_3341 74 COG1203 COG1203, Predicted helicases General function prediction only 86740282 Common - Undecaprenyl-phosphate galactosephosphotransferase Francci3_1577 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 86739903 Nonpathogen - hypothetical protein Francci3_1196 1 None None None 86741554 Common - Pyridoxal-dependent decarboxylase Francci3_2867 85 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 86741058 Common - hypothetical protein Francci3_2362 5 None None None 86740795 Common - HAD-superfamily subfamily IB, PSPase-like Francci3_2094 94 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 86741273 Common - hypothetical protein Francci3_2582 3 None None None 86739534 Common - amine oxidase Francci3_0821 30 COG3349 COG3349, Uncharacterized conserved protein Function unknown 86742247 Nonpathogen - hypothetical protein Francci3_3566 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 86740233 Common - Carbamoyl-phosphate synthase L chain, ATP-binding Francci3_1528 232 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 86742676 Nonpathogen - hypothetical protein Francci3_3997 5 None None None 86742751 Common - membrane protein-like Francci3_4074 5 COG1289 COG1289, Predicted membrane protein Function unknown 86742530 Common - glycosyl transferase, group 1 Francci3_3851 188 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86738999 Common - CobB/CobQ-like glutamine amidotransferase Francci3_0283 48 COG3442 COG3442, Predicted glutamine amidotransferase General function prediction only 86739236 Common - transcriptional regulator, XRE family Francci3_0523 3 COG1396 HipB, Predicted transcriptional regulators Transcription 86741283 Common - monooxygenase, FAD-binding Francci3_2592 30 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 86739614 Common - hypothetical protein Francci3_0901 3 COG5635 COG5635, Predicted NTPase (NACHT family) Signal transduction mechanisms 86741131 Common - hypothetical protein Francci3_2435 18 COG3595 COG3595, Uncharacterized conserved protein Function unknown 86741842 Common - NUDIX hydrolase Francci3_3156 69 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 86742861 Common - hypothetical protein Francci3_4184 53 COG2319 COG2319, FOG: WD40 repeat General function prediction only 86738944 Nonpathogen - hypothetical protein Francci3_0226 1 None None None 86741051 Common - Relaxase/mobilization nuclease Francci3_2355 7 None None None 86739654 Common - FAD dependent oxidoreductase Francci3_0941 126 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 86740289 Nonpathogen - hypothetical protein Francci3_1584 12 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 86740732 Nonpathogen - hypothetical protein Francci3_2029 1 None None None 86740632 Common - hypothetical protein Francci3_1928 3 None None None 86741578 Nonpathogen - hypothetical protein Francci3_2891 1 None None None 86740363 Nonpathogen - hypothetical protein Francci3_1658 1 None None None 86740323 Common - response regulator receiver and ANTAR domain protein Francci3_1618 224 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 86739692 Common - glycosyl transferase, family 2 Francci3_0979 27 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86741290 Common - transcriptional regulator, ArsR family Francci3_2599 39 COG0640 ArsR, Predicted transcriptional regulators Transcription 86743120 Nonpathogen - hypothetical protein Francci3_4445 1 None None None 86739143 Nonpathogen - Malic enzyme-like Francci3_0427 1 COG0281 SfcA, Malic enzyme Energy production and conversion 86738928 Common - transcriptional regulator, MarR family Francci3_0210 22 COG1846 MarR, Transcriptional regulators Transcription 86740642 Common - hydrogenase accessory protein HypB Francci3_1938 127 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 86741374 Common - Resolvase-like Francci3_2683 21 COG2452 COG2452, Predicted site-specific integrase-resolvase DNA replication, recombination, and repair 86738756 Common - phospholipid-binding protein Francci3_0033 120 COG1881 COG1881, Phospholipid-binding protein General function prediction only 86742563 Common - putative transcriptional regulator Francci3_3884 147 COG1733 COG1733, Predicted transcriptional regulators Transcription 86741970 Common - two component transcriptional regulator, winged helix family Francci3_3284 192 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86742098 Common - alpha/beta hydrolase fold Francci3_3415 120 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86742956 Common - hypothetical protein Francci3_4281 16 None None None 86742808 Nonpathogen - hypothetical protein Francci3_4131 1 None None None 86742156 Nonpathogen - hypothetical protein Francci3_3474 1 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 86741234 Common - hypothetical protein Francci3_2541 3 None None None 86742000 Common - hypothetical protein Francci3_3314 8 None None None 86742510 Nonpathogen - hypothetical protein Francci3_3831 1 None None None 86739896 Nonpathogen - Methyltransferase type 12 Francci3_1188 10 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86742222 Common - hypothetical protein Francci3_3541 31 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 86739617 Nonpathogen - hypothetical protein Francci3_0904 1 None None None 86740769 Common - aminotransferase class-III Francci3_2067 235 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 86739719 Nonpathogen - Gas vesicle synthesis GvpLGvpF Francci3_1007 4 None None None 86743005 Common - ATP-binding region, ATPase-like Francci3_4330 40 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 86740336 Common uvrA excinuclease ABC subunit A Francci3_1631 235 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 86739996 Common - protein tyrosine phosphatase Francci3_1290 35 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 86741345 Common - hypothetical protein Francci3_2654 175 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 86739723 Common - Alkaline phosphatase Francci3_1011 58 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 86739466 Common - hypothetical protein Francci3_0753 9 COG2222 AgaS, Predicted phosphosugar isomerases Cell envelope biogenesis, outer membrane 86740678 Nonpathogen - Tetracyclin repressor-like Francci3_1975 1 None None None 86741485 Nonpathogen - hypothetical protein Francci3_2798 1 None None None 86741556 Common - DNA polymerase III, alpha subunit Francci3_2869 7 None None None 86738933 Common - methane/phenol/toluene hydroxylase Francci3_0215 15 None None None 86739544 Common - putative urease accessory protein Francci3_0831 7 COG0830 UreF, Urease accessory protein UreF Posttranslational modification, protein turnover, chaperones 86742868 Common - transposase, IS204/IS1001/IS1096/IS1165 Francci3_4191 16 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739156 Common - anti-sigma-factor antagonist (STAS) domain protein Francci3_0441 38 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 86740230 Common - hypothetical protein Francci3_1525 18 None None None 86742870 Common - transposase Francci3_4193 22 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740490 Nonpathogen - hypothetical protein Francci3_1785 3 None None None 86739740 Common - cell divisionFtsK/SpoIIIE Francci3_1028 60 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 86740800 Common - Tetratricopeptide TPR_4 Francci3_2099 4 COG2096 COG2096, Uncharacterized conserved protein Function unknown 86742744 Common - glycine dehydrogenase Francci3_4065 172 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 86739406 Common - Enzymatic protein of unknown function Francci3_0693 68 COG2170 COG2170, Uncharacterized conserved protein Function unknown 86740713 Nonpathogen - hypothetical protein Francci3_2010 1 None None None 86740778 Common - luciferase-like Francci3_2076 41 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 86741763 Common - serine/threonine protein kinase Francci3_3077 154 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86741150 Common - 4-hydroxyphenylpyruvate dioxygenase Francci3_2454 79 COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins Amino acid transport and metabolism / General function prediction only 86741076 Nonpathogen - hypothetical protein Francci3_2380 1 None None None 86740503 Nonpathogen - hypothetical protein Francci3_1798 1 None None None 86739429 Common - transcriptional regulator, TetR family Francci3_0716 8 COG1309 AcrR, Transcriptional regulator Transcription 86742154 Common - Protein-tyrosine kinase Francci3_3472 156 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 86739978 Common era GTP-binding protein Era Francci3_1271 215 COG1159 Era, GTPase General function prediction only 86740266 Common - 4-hydroxybutyrate coenzyme A transferase Francci3_1561 94 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 86743166 Nonpathogen - hypothetical protein Francci3_4491 1 None None None 86739841 Nonpathogen - hypothetical protein Francci3_1133 1 None None None 86740575 Common - phage integrase-like SAM-like Francci3_1870 18 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86741159 Common - FMN-dependent alpha-hydroxy acid dehydrogenase Francci3_2463 110 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 86741581 Common - Radical SAM Francci3_2894 117 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 86741803 Common - cytochrome c oxidase, subunit II Francci3_3117 135 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 86741722 Common - transcriptional regulator, RpiR family Francci3_3036 98 COG1737 RpiR, Transcriptional regulators Transcription 86739306 Common rplX 50S ribosomal protein L24 Francci3_0593 213 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 86743021 Common - LmbE-like protein Francci3_4346 56 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 86740724 Common - ABC-2 Francci3_2021 151 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 86741891 Common - NusB antitermination factor Francci3_3205 141 COG0781 NusB, Transcription termination factor Transcription 86739043 Common - von Willebrand factor, type A Francci3_0327 14 None None None 86742338 Common - hypothetical protein Francci3_3657 4 None None None 86740068 Common - CDP-alcohol phosphatidyltransferase Francci3_1362 47 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 86742581 Nonpathogen - hypothetical protein Francci3_3902 1 None None None 86740734 Nonpathogen - putative O-methyltransferase Francci3_2031 3 None None None 86742355 Common - hypothetical protein Francci3_3674 17 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 86739823 Common - polyketide synthase-like Francci3_1114 60 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 86741450 Common - luciferase-like Francci3_2761 23 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 86740227 Common - cobalt-precorrin-6x reductase Francci3_1522 48 COG2099 CobK, Precorrin-6x reductase Coenzyme metabolism 86741677 Common - hypothetical protein Francci3_2991 37 None None None 86741310 Nonpathogen - hypothetical protein Francci3_2619 1 None None None 86740217 Nonpathogen - hypothetical protein Francci3_1512 1 None None None 86740513 Common - Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II-like Francci3_1808 49 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86739226 Common - cytochrome c assembly protein Francci3_0513 96 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 86742030 Common - CRISPR-associated protein TM1801 Francci3_3344 43 COG3649 COG3649, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 86741109 Common - major facilitator superfamily MFS_1 Francci3_2413 114 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86742048 Common - Alcohol dehydrogenase GroES-like Francci3_3364 185 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 86741123 Common - cysteine synthase A Francci3_2427 222 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 86741176 Common - hypothetical protein Francci3_2480 5 None None None 86742364 Common - thioredoxin-related Francci3_3683 229 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 86739456 Common - transcriptional regulator, TetR family Francci3_0743 60 COG1309 AcrR, Transcriptional regulator Transcription 86741967 Nonpathogen - hypothetical protein Francci3_3281 1 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86739346 Common groEL chaperonin GroEL Francci3_0633 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 86738949 Common - oxidoreductase FAD/NAD(P)-binding Francci3_0231 100 COG4097 COG4097, Predicted ferric reductase Inorganic ion transport and metabolism 86741745 Common - phosphoesterase, PA-phosphatase related Francci3_3059 75 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 86740531 Common - transcriptional coactivator/pterin dehydratase Francci3_1826 32 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 86740901 Common - isocitrate dehydrogenase, NADP-dependent Francci3_2203 65 COG2838 Icd, Monomeric isocitrate dehydrogenase Energy production and conversion 86739092 Common - hypothetical protein Francci3_0376 42 COG3304 COG3304, Predicted membrane protein Function unknown 86741332 Nonpathogen - hypothetical protein Francci3_2641 1 None None None 86739766 Nonpathogen - glycosyl transferase, family 39 Francci3_1055 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 86742519 Common - conserved hypothetical protein 730 Francci3_3840 106 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 86740972 Common - 5'-3' exonuclease Francci3_2275 216 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 86740994 Common - cobyrinic acid a,c-diamide synthase Francci3_2297 136 COG1797 CobB, Cobyrinic acid a,c-diamide synthase Coenzyme metabolism 86741637 Common - CoA-binding Francci3_2950 146 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 86741281 Common - putative phosphoesterase Francci3_2590 16 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 86741861 Common - N-acetyl-gamma-glutamyl-phosphate reductase Francci3_3175 211 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 86740416 Nonpathogen - hypothetical protein Francci3_1711 1 None None None 86739102 Nonpathogen - protein of unknown function DUF433 Francci3_0386 8 COG2442 COG2442, Uncharacterized conserved protein Function unknown 161353754 Common - hypothetical protein Francci3_2786 79 COG1742 COG1742, Uncharacterized conserved protein Function unknown 86739658 Nonpathogen - hypothetical protein Francci3_0945 4 None None None 86742708 Common - hypothetical protein Francci3_4029 6 COG5485 COG5485, Predicted ester cyclase General function prediction only 86740535 Nonpathogen - hypothetical protein Francci3_1830 1 None None None 86739314 Common rplO 50S ribosomal protein L15 Francci3_0601 218 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 86739943 Nonpathogen - hypothetical protein Francci3_1236 1 COG1584 COG1584, Predicted membrane protein Function unknown 86739430 Common - Drug resistance transporter EmrB/QacA subfamily Francci3_0717 176 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86739748 Common - polysaccharide deacetylase Francci3_1037 121 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 86742499 Common - Alkaline phosphatase Francci3_3820 56 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 86740581 Common - putative transposase Francci3_1876 5 None None None 86741270 Nonpathogen - hypothetical protein Francci3_2579 1 None None None 86739911 Common tig trigger factor Francci3_1204 213 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 86740666 Common - transposase, IS4 Francci3_1962 28 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86743036 Nonpathogen - NAD-dependent epimerase/dehydratase Francci3_4361 1 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 86742453 Common - Histidinol-phosphate phosphatase, putative, inositol monophosphatase Francci3_3773 185 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 86738942 Common - NAD-dependent epimerase/dehydratase Francci3_0224 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 86740497 Nonpathogen - hypothetical protein Francci3_1792 1 None None None 86739901 Nonpathogen - hypothetical protein Francci3_1194 1 None None None 86740908 Nonpathogen - hypothetical protein Francci3_2210 1 None None None 86741991 Common - Type IV secretory pathway VirD4 components-like Francci3_3305 29 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 86742205 Common - metal dependent phosphohydrolase Francci3_3523 76 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 86740030 Common - hypothetical protein Francci3_1324 56 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 86743009 Common - putative cytochrome P450 Francci3_4334 61 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 86742902 Common - transposase, IS4 Francci3_4227 33 COG5659 COG5659, FOG: Transposase DNA replication, recombination, and repair 86740463 Nonpathogen - hypothetical protein Francci3_1758 1 None None None 86739875 Common - glycosyl transferase, group 1 Francci3_1167 41 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86738907 Common - ABC transporter related Francci3_0187 243 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 86742286 Common - Coenzyme A biosynthesis protein Francci3_3605 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 86740190 Nonpathogen - hypothetical protein Francci3_1485 1 None None None 86743031 Common - ATPase AAA-2 Francci3_4356 217 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 86740540 Nonpathogen - hypothetical protein Francci3_1835 2 None None None 86742880 Common - monooxygenase, FAD-binding Francci3_4203 93 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 86740951 Common - binding-protein-dependent transport systems inner membrane component Francci3_2254 137 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 86739539 Common - Phenylacetic acid degradation-related protein Francci3_0826 41 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 86740149 Nonpathogen - Prevent-host-death protein Francci3_1443 1 None None None 86743201 Common - glycosyl transferase, family 51 Francci3_4526 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 86741492 Common - HpcH/HpaI aldolase Francci3_2805 112 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 86741459 Common - 4-hydroxyphenylacetate 3-hydroxylase Francci3_2770 50 COG2368 COG2368, Aromatic ring hydroxylase Secondary metabolites biosynthesis, transport, and catabolism 86742337 Common - hypothetical protein Francci3_3656 8 None None None 86739372 Nonpathogen - hypothetical protein Francci3_0659 1 None None None 86740890 Nonpathogen - DNA polymerase, beta-like region Francci3_2192 2 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 86738814 Nonpathogen - hypothetical protein Francci3_0091 4 None None None 86739710 Common - hypothetical protein Francci3_0998 11 None None None 86741180 Common - hypothetical protein Francci3_2484 13 COG4908 COG4908, Uncharacterized protein containing a NRPS condensation (elongation) domain General function prediction only 86741017 Nonpathogen - hypothetical protein Francci3_2320 1 None None None 86738738 Common - glycosyl transferase, family 2 Francci3_0015 113 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86742512 Common - RNA polymerase sigma factor SigE Francci3_3833 144 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 86740145 Nonpathogen - hypothetical protein Francci3_1439 4 None None None 86740188 Common - Rhodanese-like Francci3_1483 55 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 86739075 Common - serine/threonine protein kinase Francci3_0359 141 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86739107 Nonpathogen - transposase, IS4 Francci3_0391 8 COG5659 COG5659, FOG: Transposase DNA replication, recombination, and repair 86739785 Common - hypothetical protein Francci3_1074 17 None None None 86740653 Common - putative DNA-binding protein Francci3_1949 45 COG1278 CspC, Cold shock proteins Transcription 86738831 Common - Twin-arginine translocation pathway signal Francci3_0108 31 COG3485 PcaH, Protocatechuate 3,4-dioxygenase beta subunit Secondary metabolites biosynthesis, transport, and catabolism 86742103 Nonpathogen - hypothetical protein Francci3_3420 2 COG3889 COG3889, Predicted solute binding protein General function prediction only 86739000 Common - Poly(3-hydroxybutyrate) depolymerase-like Francci3_0284 8 COG3509 LpqC, Poly(3-hydroxybutyrate) depolymerase Secondary metabolites biosynthesis, transport, and catabolism 86738974 Common - cytochrome bd ubiquinol oxidase, subunit II Francci3_0257 140 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 86740108 Common - hypothetical protein Francci3_1402 13 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 86738877 Nonpathogen - hypothetical protein Francci3_0155 1 None None None 86743011 Common - PilT protein-like Francci3_4336 50 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 86739394 Common - succinate dehydrogenase, cytochrome b subunit Francci3_0681 19 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 86741464 Common - transposase, IS605 OrfB Francci3_2775 69 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739199 Common - redox-sensing transcriptional repressor Rex Francci3_0484 56 COG2344 COG2344, AT-rich DNA-binding protein General function prediction only 86741315 Common - short-chain dehydrogenase/reductase SDR Francci3_2624 188 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 86740485 Common - transcriptional regulator, XRE family Francci3_1780 6 None None None 86738806 Common - Citrate synthase I Francci3_0083 194 COG0372 GltA, Citrate synthase Energy production and conversion 86740696 Nonpathogen - hypothetical protein Francci3_1993 1 COG1584 COG1584, Predicted membrane protein Function unknown 86739392 Common sdhA succinate dehydrogenase flavoprotein subunit Francci3_0679 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 86741168 Common - sigma-24 Francci3_2472 64 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 86743050 Common - pantoate--beta-alanine ligase Francci3_4375 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 86739127 Nonpathogen - hypothetical protein Francci3_0411 2 None None None 86740050 Nonpathogen - hypothetical protein Francci3_1344 1 None None None 86739737 Nonpathogen - transcriptional regulator, XRE family Francci3_1025 2 None None None 86740826 Common - hypothetical protein Francci3_2125 6 None None None 86740342 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Francci3_1637 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 86739984 Common - protein of unknown function DUF218 Francci3_1277 63 COG1434 COG1434, Uncharacterized conserved protein Function unknown 86741719 Common - 4Fe-4S ferredoxin, iron-sulfur binding Francci3_3033 136 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 86740958 Common - Stearoyl-CoA 9-desaturase Francci3_2261 67 COG1398 OLE1, Fatty-acid desaturase Lipid metabolism 86740059 Common - hypothetical protein Francci3_1353 17 None None None 86742572 Nonpathogen - hypothetical protein Francci3_3893 1 None None None 86740875 Common - hypothetical protein Francci3_2176 4 None None None 86740495 Nonpathogen - hypothetical protein Francci3_1790 1 None None None 86740844 Common - hypothetical protein Francci3_2143 13 None None None 86739007 Common - multi-sensor signal transduction histidine kinase Francci3_0291 220 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 86742475 Common - peptidase M16-like Francci3_3796 184 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 86740650 Common - hydrogenase assembly chaperone hypC/hupF Francci3_1946 92 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 86742559 Common xseA exodeoxyribonuclease VII large subunit Francci3_3880 204 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 86740044 Common - Undecaprenyl-phosphate galactosephosphotransferase Francci3_1338 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 86743176 Common - NUDIX hydrolase Francci3_4501 25 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 86739263 Common - NADH dehydrogenase subunit M Francci3_0550 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 86743213 Common - cell wall hydrolase/autolysin Francci3_4538 43 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 86739416 Nonpathogen - hypothetical protein Francci3_0703 1 None None None 86739640 Common - beta-ketoacyl synthase Francci3_0927 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 86742070 Nonpathogen - hypothetical protein Francci3_3387 1 None None None 86741391 Nonpathogen - hypothetical protein Francci3_2701 1 None None None 86740605 Common - CMP/dCMP deaminase, zinc-binding Francci3_1900 141 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 86739570 Common - NAD-dependent epimerase/dehydratase Francci3_0857 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 86740120 Common - cell cycle protein Francci3_1414 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 86741805 Nonpathogen - putative aminotransferase Francci3_3119 2 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 86742142 Common - LmbE-like protein Francci3_3459 25 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 86740200 Common - putative transcriptional regulator, TetR family Francci3_1495 32 None None None 86739154 Common - selenocysteine synthase Francci3_0439 64 COG1921 SelA, Selenocysteine synthase [seryl-tRNASer selenium transferase] Amino acid transport and metabolism 86739636 Common - ATP-dependent transcriptional regulator, MalT-like, LuxR family Francci3_0923 44 COG2909 MalT, ATP-dependent transcriptional regulator Transcription 86740181 Common - cell divisionFtsK/SpoIIIE Francci3_1475 31 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 86741522 Common - protein tyrosine/serine phosphatase Francci3_2835 42 COG2365 COG2365, Protein tyrosine/serine phosphatase Signal transduction mechanisms 86741564 Common - PilT protein-like Francci3_2877 2 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 86741834 Common - transcriptional regulator, TetR family Francci3_3148 46 COG1309 AcrR, Transcriptional regulator Transcription 86742771 Nonpathogen - hypothetical protein Francci3_4094 1 None None None 86740408 Nonpathogen - hypothetical protein Francci3_1703 1 None None None 86739439 Nonpathogen - hypothetical protein Francci3_0726 3 None None None 86739603 Nonpathogen - hypothetical protein Francci3_0890 3 None None None 86741476 Common - ATPase AAA-2 Francci3_2789 215 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 86740739 Nonpathogen - hypothetical protein Francci3_2036 2 None None None 86740931 Common - ABC transporter related Francci3_2234 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 86742125 Common - ABC-type branched-chain amino acid transport systems periplasmic component-like Francci3_3442 40 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 86739038 Common - WD-40 repeat protein Francci3_0322 234 COG2319 COG2319, FOG: WD40 repeat General function prediction only 86739377 Common - Serine-type D-Ala-D-Ala carboxypeptidase Francci3_0664 153 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 86740101 Common - GCN5-related N-acetyltransferase Francci3_1395 11 COG0456 RimI, Acetyltransferases General function prediction only 86740458 Common - Radical SAM Francci3_1753 86 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 86739137 Common - nitrogen regulatory protein P-II Francci3_0421 187 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 86741322 Nonpathogen - hypothetical protein Francci3_2631 4 COG1141 Fer, Ferredoxin Energy production and conversion 86741694 Common - protein of unknown function DUF81 Francci3_3008 18 COG0730 COG0730, Predicted permeases General function prediction only 86742328 Common - DNA ligase, NAD-dependent Francci3_3647 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 86740028 Common - TrkA-like Francci3_1322 177 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 86738819 Common - conserved hypothetical protein-fragment Francci3_0096 9 None None None 86739099 Common - thiamine biosynthesis protein ThiC Francci3_0383 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 86739571 Nonpathogen - transcriptional regulator, XRE family Francci3_0858 2 COG1396 HipB, Predicted transcriptional regulators Transcription 86739442 Common - isoleucine patch superfamily acetyltransferase Francci3_0729 105 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 86740441 Common - type II secretion system protein E Francci3_1736 198 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 86740707 Common - Drug resistance transporter EmrB/QacA subfamily Francci3_2004 166 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 86740561 Common - Excisionase/Xis, DNA-binding Francci3_1856 29 None None None 86740851 Common - putative IS630 family transposase Francci3_2150 27 None None None 86742788 Common - putative cytochrome P450 Francci3_4111 61 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 86738872 Common - methylated-DNA--protein-cysteine methyltransferase Francci3_0149 79 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 86740287 Nonpathogen - hypothetical protein Francci3_1582 1 None None None 86741087 Common - luciferase-like Francci3_2391 52 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 86739424 Common - cell envelope-related transcriptional attenuator Francci3_0711 58 COG1316 LytR, Transcriptional regulator Transcription 86740476 Common - hypothetical protein Francci3_1771 5 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 86738844 Nonpathogen - transposase, IS4 Francci3_0121 8 COG5659 COG5659, FOG: Transposase DNA replication, recombination, and repair 86739811 Common - putative DNA methyltransferase Francci3_1102 35 COG4889 COG4889, Predicted helicase General function prediction only 86742267 Common - protein of unknown function UPF0102 Francci3_3586 101 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 86740425 Nonpathogen - hypothetical protein Francci3_1720 1 None None None 86740359 Common - ABC-2 Francci3_1654 14 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 86740395 Nonpathogen - hypothetical protein Francci3_1690 2 None None None 86739449 Common - glycosyl transferase, family 2 Francci3_0736 120 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 86739796 Common - FAD linked oxidase-like Francci3_1085 43 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 86741066 Common - two component transcriptional regulator, winged helix family Francci3_2370 221 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86741576 Common - putative DNA-binding protein Francci3_2889 7 None None None 86741794 Common - Heme/copper-type cytochrome/quinol oxidase subunit 3-like Francci3_3108 159 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 86742384 Common - hypothetical protein Francci3_3703 9 None None None 86743187 Common - protein of unknown function DUF323 Francci3_4512 103 COG1262 COG1262, Uncharacterized conserved protein Function unknown 86743068 Nonpathogen - hypothetical protein Francci3_4393 2 None None None 86740523 Nonpathogen - hypothetical protein Francci3_1818 1 None None None 86742260 Common - ribosome recycling factor Francci3_3579 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 86742628 Common - glycosyl transferase, group 1 Francci3_3949 62 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86742135 Common - galactose-1-phosphate uridylyltransferase Francci3_3452 69 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 86741922 Nonpathogen - hypothetical protein Francci3_3236 1 None None None 86742119 Common - transposase IS116/IS110/IS902 Francci3_3436 80 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742716 Common - molybdopterin binding domain Francci3_4037 188 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 86742967 Common - Colicin V production protein Francci3_4292 24 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 86739585 Common - glutamate racemase Francci3_0872 189 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 86740671 Common - ISRSO5-transposase protein Francci3_1967 48 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740924 Common - hypothetical protein Francci3_2227 6 COG3462 COG3462, Predicted membrane protein Function unknown 86741954 Common - hypothetical protein Francci3_3268 5 None None None 86742115 Common - hypothetical protein Francci3_3432 6 None None None 86743102 Nonpathogen - hypothetical protein Francci3_4427 1 None None None 86741370 Common - plasmid stabilization system Francci3_2679 8 COG2026 RelE, Cytotoxic translational repressor of toxin-antitoxin stability system Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning 86741733 Nonpathogen - Radical SAM Francci3_3047 1 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 86741241 Nonpathogen - hypothetical protein Francci3_2548 1 None None None 86742983 Common - PSP1 Francci3_4308 58 COG1774 COG1774, Uncharacterized homolog of PSP1 Function unknown 86740916 Common - Protein of unknown function Mtu_121 Francci3_2218 25 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 86741627 Common - protein of unknown function DUF1524 RloF Francci3_2940 63 COG1479 COG1479, Uncharacterized conserved protein Function unknown 86741845 Common ppnK inorganic polyphosphate/ATP-NAD kinase Francci3_3159 229 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 86742883 Common - 3-dehydroquinate synthase Francci3_4206 28 COG1465 COG1465, Predicted alternative 3-dehydroquinate synthase Amino acid transport and metabolism 86739807 Common - hypothetical protein Francci3_1097 3 None None None 86740853 Common - PAS/PAC sensor hybrid histidine kinase Francci3_2152 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 86741302 Common - peptidylprolyl isomerase, FKBP-type Francci3_2611 125 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 86740280 Common - protein of unknown function DUF218 Francci3_1575 6 COG1434 COG1434, Uncharacterized conserved protein Function unknown 86741447 Common - transcriptional regulator, TetR family Francci3_2758 28 COG1309 AcrR, Transcriptional regulator Transcription 86741328 Common - HAD-superfamily hydrolase subfamily IA, variant 3 Francci3_2637 184 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 86741917 Nonpathogen - Abortive infection protein Francci3_3231 5 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 86739816 Common - Rhodopirellula transposase Francci3_1107 11 None None None 86740036 Common - Acetyl-CoA C-acyltransferase Francci3_1330 166 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 86740436 Nonpathogen - hypothetical protein Francci3_1731 1 None None None 86741823 Common - peptidase S51, dipeptidase E Francci3_3137 15 COG3340 PepE, Peptidase E Amino acid transport and metabolism 86740911 Nonpathogen - hypothetical protein Francci3_2213 1 None None None 86741552 Common - helicase-like Francci3_2865 221 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 86739553 Common - allantoicase Francci3_0840 23 COG4266 Alc, Allantoicase Nucleotide transport and metabolism 86742109 Nonpathogen - hypothetical protein Francci3_3426 1 None None None 86742121 Nonpathogen - hypothetical protein Francci3_3438 1 None None None 86740409 Nonpathogen - hypothetical protein Francci3_1704 1 None None None 86738817 Common - amidophosphoribosyltransferase Francci3_0094 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 86739444 Common - glycosyl transferase, group 1 Francci3_0731 43 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86742190 Common - hypothetical protein Francci3_3508 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 86741325 Common - putative RecB family exonuclease Francci3_2634 15 COG2887 COG2887, RecB family exonuclease DNA replication, recombination, and repair 86740494 Nonpathogen - hypothetical protein Francci3_1789 1 None None None 86742175 Common - hypothetical protein Francci3_3493 15 COG3846 TrbL, Type IV secretory pathway, TrbL components Intracellular trafficking and secretion 86739056 Common - L-carnitine dehydratase/bile acid-inducible protein F Francci3_0340 109 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 86740566 Common - 2-dehydropantoate 2-reductase Francci3_1861 112 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 86740859 Nonpathogen - hypothetical protein Francci3_2159 1 None None None 86740814 Common - isochorismatase hydrolase Francci3_2113 37 COG1535 EntB, Isochorismate hydrolase Secondary metabolites biosynthesis, transport, and catabolism 86739869 Common - protein of unknown function UPF0118 Francci3_1161 60 COG0628 PerM, Predicted permease General function prediction only 86740606 Nonpathogen - hypothetical protein Francci3_1901 2 None None None 86741921 Common - alpha/beta hydrolase fold Francci3_3235 149 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86740854 Common - response regulator receiver protein Francci3_2153 90 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 86741802 Common - Cytochrome-c oxidase Francci3_3116 165 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 86740479 Common - sulfotransferase domain protein Francci3_1774 18 None None None 86740888 Common - hypothetical protein Francci3_2190 21 None None None 86742789 Common - putative IS630 family transposase Francci3_4112 22 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 86738873 Nonpathogen - putative 3-carboxy-cis,cis-muconate cycloisomerase Francci3_0150 5 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 86739630 Common - hypothetical protein Francci3_0917 6 COG0392 COG0392, Predicted integral membrane protein Function unknown 86740821 Nonpathogen - hypothetical protein Francci3_2120 5 None None None 86740918 Common - Phenylacetic acid degradation-related protein Francci3_2221 77 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 86740314 Common - Chromate transporter Francci3_1609 110 COG2059 ChrA, Chromate transport protein ChrA Inorganic ion transport and metabolism 86739919 Common - Rod shape-determining protein MreC Francci3_1212 61 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 86741781 Common - cyclase/dehydrase Francci3_3095 8 None None None 86739813 Common - transposase IS66 Francci3_1104 44 None None None 86742487 Common - hypothetical protein Francci3_3808 13 None None None 86738829 Common - glycosyl transferase, family 2 Francci3_0106 4 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86740212 Common - hypothetical protein Francci3_1507 4 COG3917 NahD, 2-hydroxychromene-2-carboxylate isomerase Secondary metabolites biosynthesis, transport, and catabolism 86738858 Nonpathogen - hypothetical protein Francci3_0135 1 None None None 86741390 Common - putative signal transduction histidine kinase Francci3_2700 4 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 86741477 Common - GCN5-related N-acetyltransferase Francci3_2790 13 COG0456 RimI, Acetyltransferases General function prediction only 86742632 Nonpathogen - hypothetical protein Francci3_3953 1 None None None 86740990 Nonpathogen - hypothetical protein Francci3_2293 1 None None None 86740923 Common - GCN5-related N-acetyltransferase Francci3_2226 98 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 86741939 Common - two component transcriptional regulator, LuxR family Francci3_3253 188 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86741849 Common - HAD-superfamily hydrolase, subfamily IIA Francci3_3163 75 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 86741127 Common - NUDIX hydrolase Francci3_2431 15 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 86743103 Common - Haloacid dehalogenase-like hydrolase Francci3_4428 9 COG0546 Gph, Predicted phosphatases General function prediction only 86742508 Common - sec-independent translocase Francci3_3829 12 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 86742526 Nonpathogen - hypothetical protein Francci3_3847 10 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 86740448 Nonpathogen - hypothetical protein Francci3_1743 1 None None None 86741620 Common - lipolytic enzyme, G-D-S-L Francci3_2933 21 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 86739819 Nonpathogen - hypothetical protein Francci3_1110 2 None None None 86741731 Nonpathogen - hypothetical protein Francci3_3045 1 None None None 86740852 Nonpathogen - hypothetical protein Francci3_2151 2 None None None 86739011 Nonpathogen - heat shock protein DnaJ-like Francci3_0295 1 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 86742160 Common - Lytic transglycosylase Francci3_3478 116 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 86741416 Nonpathogen - hypothetical protein Francci3_2727 1 None None None 86740868 Common - methylmalonyl-CoA mutase Francci3_2169 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 86742182 Common - ABC transporter related Francci3_3500 249 COG1119 ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA Inorganic ion transport and metabolism 86743013 Nonpathogen - phage integrase Francci3_4338 1 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86738730 Common - DNA gyrase subunit A Francci3_0007 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 86742627 Common - glycosyl transferase, family 2 Francci3_3948 42 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86741375 Common - transposase IS200-like Francci3_2684 67 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741320 Common - protein of unknown function DUF245-like Francci3_2629 16 None None None 86741082 Nonpathogen - hypothetical protein Francci3_2386 1 None None None 86740430 Nonpathogen - hypothetical protein Francci3_1725 1 None None None 86741703 Common trpC indole-3-glycerol-phosphate synthase Francci3_3017 219 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 86742483 Common - CsbD-like Francci3_3804 11 None None None 86739111 Nonpathogen - hypothetical protein Francci3_0395 1 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 86739810 Nonpathogen - hypothetical protein Francci3_1101 1 None None None 86742232 Common - NAD-dependent epimerase/dehydratase Francci3_3551 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 86739652 Common - acyl-CoA dehydrogenase-like Francci3_0939 142 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 86740705 Nonpathogen - hypothetical protein Francci3_2002 1 None None None 86741067 Common - protein of unknown function DUF347 Francci3_2371 27 COG4705 COG4705, Uncharacterized membrane-anchored protein conserved in bacteria Function unknown 86741825 Nonpathogen - hypothetical protein Francci3_3139 1 None None None 86742488 Common - DEAD/DEAH box helicase-like Francci3_3809 238 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 86739155 Nonpathogen - hypothetical protein Francci3_0440 1 None None None 86738812 Common - response regulator receiver protein Francci3_0089 75 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86740023 Nonpathogen - hypothetical protein Francci3_1317 1 None None None 86740060 Common - hypothetical protein Francci3_1354 19 None None None 86741093 Common - putative ATP/GTP binding protein Francci3_2397 32 COG3973 COG3973, Superfamily I DNA and RNA helicases General function prediction only 86741555 Common - Phosphoesterase PHP-like Francci3_2868 80 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 86739587 Common - 6-phosphogluconate dehydrogenase, NAD-binding Francci3_0874 168 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 86740281 Common - glycosyl transferase, family 2 Francci3_1576 156 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 86738801 Nonpathogen - hypothetical protein Francci3_0078 1 None None None 86740898 Common - hypothetical protein Francci3_2200 3 None None None 86743074 Common - protein of unknown function DUF820 Francci3_4399 22 COG4636 Uma2, Uncharacterized protein conserved in cyanobacteria Function unknown 86739638 Common - transcriptional regulator, LuxR family Francci3_0925 65 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86739047 Common - hypothetical protein Francci3_0331 11 None None None 86741787 Nonpathogen - hypothetical protein Francci3_3101 1 COG1345 FliD, Flagellar capping protein Cell motility and secretion 86738901 Nonpathogen - hypothetical protein Francci3_0180 1 None None None 86739300 Common rplV 50S ribosomal protein L22 Francci3_0587 216 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 86742128 Common - protein of unknown function DUF397 Francci3_3445 6 None None None 86742239 Common truB tRNA pseudouridine synthase B Francci3_3558 242 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 86741997 Nonpathogen - hypothetical protein Francci3_3311 1 None None None 86742999 Common - sigma-24 Francci3_4324 20 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 86741053 Nonpathogen - hypothetical protein Francci3_2357 1 None None None 86742908 Common - protein of unknown function DUF181 Francci3_4233 17 COG1944 COG1944, Uncharacterized conserved protein Function unknown 86742169 Common - AAA ATPase, central region Francci3_3487 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 86739596 Common - transcriptional regulator, XRE family Francci3_0883 10 COG1396 HipB, Predicted transcriptional regulators Transcription 86743184 Nonpathogen - hypothetical protein Francci3_4509 6 None None None 86740909 Nonpathogen - hypothetical protein Francci3_2211 2 None None None 86742992 Common hisE phosphoribosyl-ATP pyrophosphatase Francci3_4317 18 COG0140 HisI, Phosphoribosyl-ATP pyrophosphohydrolase Amino acid transport and metabolism 86740659 Nonpathogen - hypothetical protein Francci3_1955 1 COG5602 SIN3, Histone deacetylase complex, SIN3 component Chromatin structure and dynamics 86739120 Common - hypothetical protein Francci3_0404 3 None None None 86740675 Nonpathogen - hypothetical protein Francci3_1972 1 None None None 86740226 Common - precorrin-3B C17-methyltransferase Francci3_1521 180 COG1010 CobJ, Precorrin-3B methylase Coenzyme metabolism 86742476 Common - hypothetical protein Francci3_3797 12 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 86741892 Common - elongation factor P Francci3_3206 217 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 86740197 Common - Methenyltetrahydrofolate cyclohydrolase Francci3_1492 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 86739294 Common rpsJ 30S ribosomal protein S10 Francci3_0581 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 86740407 Nonpathogen - hypothetical protein Francci3_1702 1 None None None 86742579 Common - protein of unknown function DUF255 Francci3_3900 105 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 86740459 Common - PfkB Francci3_1754 23 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 86740422 Nonpathogen - hypothetical protein Francci3_1717 1 None None None 86740400 Nonpathogen - hypothetical protein Francci3_1695 3 None None None 86742354 Common - Heat shock protein 70 Francci3_3673 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 86741397 Common - transposase, IS4 Francci3_2707 56 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86743199 Common - hypothetical protein Francci3_4524 4 COG5542 COG5542, Predicted integral membrane protein Function unknown 86742615 Nonpathogen - lipopolysaccharide biosynthesis Francci3_3936 1 COG3944 COG3944, Capsular polysaccharide biosynthesis protein Cell envelope biogenesis, outer membrane 86742741 Common - hypothetical protein Francci3_4062 14 None None None 86739265 Common - Polyprenyl synthetase Francci3_0552 241 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 86742553 Common - polysaccharide deacetylase Francci3_3874 39 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 86742828 Common - actinorhodin polyketide synthase bifunctional cyclase/dehydratase Francci3_4151 5 None None None 86741199 Common - 3-oxoacid CoA-transferase, subunit B Francci3_2503 103 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 86740415 Common - DNA polymerase III, beta chain Francci3_1710 16 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 86738834 Common - putative transposase, IS891/IS1136/IS1341 Francci3_0111 37 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740973 Common - HAD-superfamily subfamily IB, PSPase-like Francci3_2276 70 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 86742987 Common - hypothetical protein Francci3_4312 27 COG5282 COG5282, Uncharacterized conserved protein Function unknown 86739645 Common - hypothetical protein Francci3_0932 3 None None None 86740440 Common - putative integral membrane protein Francci3_1735 6 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 86739478 Common - two component transcriptional regulator, LuxR family Francci3_0765 209 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86739197 Common - sigma-24 Francci3_0482 148 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 86742299 Common - polyphosphate kinase Francci3_3618 162 COG0855 Ppk, Polyphosphate kinase Inorganic ion transport and metabolism 86740348 Common - serine/threonine protein kinase Francci3_1643 149 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86740487 Nonpathogen - hypothetical protein Francci3_1782 1 None None None 86742859 Nonpathogen - hypothetical protein Francci3_4182 1 None None None 86742252 Common - ABC transporter, substrate-binding protein, aliphatic sulphonates Francci3_3571 92 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 86741586 Nonpathogen - hypothetical protein Francci3_2899 1 None None None 86738775 Common - hypothetical protein Francci3_0052 8 None None None 86740848 Common - phage integrase Francci3_2147 178 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86742002 Common - protein-L-isoaspartate(D-aspartate) O-methyltransferase Francci3_3316 144 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 86741468 Common - transcriptional regulator, MerR family Francci3_2780 140 COG0789 SoxR, Predicted transcriptional regulators Transcription 86739087 Nonpathogen - hypothetical protein Francci3_0371 1 None None None 86741498 Common - serine/threonine protein kinase Francci3_2811 123 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86740386 Common - PilT protein-like Francci3_1681 54 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 86740779 Nonpathogen - hypothetical protein Francci3_2077 1 None None None 86742271 Common rplS 50S ribosomal protein L19 Francci3_3590 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 86739003 Common - magnesium and cobalt transport protein CorA Francci3_0287 161 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 86740770 Common - Salicylate 1-monooxygenase Francci3_2068 106 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 86740429 Nonpathogen - hypothetical protein Francci3_1724 1 None None None 86741494 Common - aminotransferase, class I and II Francci3_2807 221 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 86743190 Common - dihydroxy-acid dehydratase Francci3_4515 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 86741820 Common - dihydrolipoamide dehydrogenase Francci3_3134 241 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 86741107 Common - Methyltransferase type 12 Francci3_2411 14 COG5459 COG5459, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 86739795 Common - hypothetical protein Francci3_1084 12 None None None 86739931 Nonpathogen - hypothetical protein Francci3_1224 1 None None None 86740978 Common - transcriptional regulator, XRE family Francci3_2281 61 COG1476 COG1476, Predicted transcriptional regulators Transcription 86740634 Common - cytochrome P450 Francci3_1930 89 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 86740646 Common - Hydrogen:quinone oxidoreductase Francci3_1942 87 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 86741670 Common - hypothetical protein Francci3_2984 5 None None None 86739991 Common - glycosyl transferase, group 1 Francci3_1284 35 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86740264 Common - hypothetical protein Francci3_1559 7 None None None 86742455 Nonpathogen - hypothetical protein Francci3_3775 1 None None None 86742706 Common - transcriptional regulator, LuxR family Francci3_4027 79 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86740357 Common - NADPH-dependent FMN reductase Francci3_1652 62 COG0431 COG0431, Predicted flavoprotein General function prediction only 86741882 Common - putative integration host factor MihF Francci3_3196 16 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 86742674 Common - hypothetical protein Francci3_3995 5 None None None 86739955 Nonpathogen - hypothetical protein Francci3_1248 1 None None None 86739379 Nonpathogen - GCN5-related N-acetyltransferase Francci3_0666 2 COG0456 RimI, Acetyltransferases General function prediction only 86738860 Nonpathogen - hypothetical protein Francci3_0137 1 None None None 86741712 Common - histidinol-phosphate aminotransferase Francci3_3026 225 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 86739537 Common - hydroxymethylbutenyl pyrophosphate reductase Francci3_0824 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 86741725 Common - Stress responsive alpha-beta barrel Francci3_3039 3 None None None 86739846 Nonpathogen - hypothetical protein Francci3_1138 1 None None None 86738970 Common - ROK Francci3_0253 111 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 86741953 Common - transposase, IS605 OrfB Francci3_3267 67 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742029 Common - hypothetical protein Francci3_3343 25 None None None 86742134 Common - galactokinase Francci3_3451 77 COG0153 GalK, Galactokinase Carbohydrate transport and metabolism 86743169 Common - peptidase M50 Francci3_4494 53 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 86742366 Common - histidine kinase Francci3_3685 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 86742518 Common - dihydropteroate synthase Francci3_3839 215 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 86742200 Common - tRNA-i(6)A37 modification enzyme MiaB Francci3_3518 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 86742875 Common - protein of unknown function DUF181 Francci3_4198 44 COG1944 COG1944, Uncharacterized conserved protein Function unknown 86739287 Common - DNA-directed RNA polymerase subunit beta' Francci3_0574 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 86739747 Nonpathogen - hypothetical protein Francci3_1036 1 COG2845 COG2845, Uncharacterized protein conserved in bacteria Function unknown 86739771 Nonpathogen - hypothetical protein Francci3_1060 4 COG4124 ManB, Beta-mannanase Carbohydrate transport and metabolism 86740142 Common - protein of unknown function DUF34 Francci3_1436 79 COG0327 COG0327, Uncharacterized conserved protein Function unknown 86741232 Nonpathogen - hypothetical protein Francci3_2539 2 None None None 86742402 Common rpmE 50S ribosomal protein L31 Francci3_3721 30 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 86741488 Common - hypothetical protein Francci3_2801 16 None None None 86740785 Common - ISRSO5-transposase protein Francci3_2084 48 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741693 Common - hypothetical protein Francci3_3007 5 None None None 86738822 Common - Excisionase/Xis, DNA-binding Francci3_0099 12 COG2452 COG2452, Predicted site-specific integrase-resolvase DNA replication, recombination, and repair 86740710 Common - FAD linked oxidase-like Francci3_2007 199 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 86739870 Common - ribose-5-phosphate isomerase B Francci3_1162 126 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 86738883 Common - transcriptional regulator, MerR family Francci3_0162 132 COG0789 SoxR, Predicted transcriptional regulators Transcription 86740949 Common - extracellular solute-binding protein, family 1 Francci3_2252 106 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 86741187 Nonpathogen - hypothetical protein Francci3_2491 1 None None None 86742704 Common - transcriptional regulator, LuxR family Francci3_4025 60 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86741542 Common - Polyketide synthesis cyclase Francci3_2855 4 None None None 86742496 Common - MgtE intracellular region Francci3_3817 163 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 86739078 Common - hypothetical protein Francci3_0362 8 COG5617 COG5617, Predicted integral membrane protein Function unknown 86739076 Common - serine/threonine protein kinase Francci3_0360 132 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86741638 Common - prephenate dehydratase Francci3_2951 212 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 86740940 Nonpathogen - hypothetical protein Francci3_2243 5 None None None 86739762 Common - glycosyl transferase, group 1 Francci3_1051 200 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86742764 Nonpathogen - hypothetical protein Francci3_4087 1 None None None 86742780 Common - short-chain dehydrogenase/reductase SDR Francci3_4103 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 86740902 Nonpathogen - hypothetical protein Francci3_2204 2 COG4713 COG4713, Predicted membrane protein Function unknown 86740512 Common - hypothetical protein Francci3_1807 5 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 86741201 Common - hypothetical protein Francci3_2505 8 None None None 86742097 Nonpathogen - hypothetical protein Francci3_3414 1 None None None 86740331 Common - excinuclease ABC subunit B Francci3_1626 224 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 86739018 Common - ABC-type multidrug transport system ATPase component Francci3_0302 124 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 86742970 Common - hypothetical protein Francci3_4295 9 COG3177 COG3177, Uncharacterized conserved protein Function unknown 86741100 Common - flavin reductase-like, FMN-binding Francci3_2404 115 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 86742655 Common - glycoside hydrolase, family 43 Francci3_3976 9 COG3507 XynB, Beta-xylosidase Carbohydrate transport and metabolism 86741928 Common - hypothetical protein Francci3_3242 15 COG5446 COG5446, Predicted integral membrane protein Function unknown 86739428 Common - dTDP-4-dehydrorhamnose reductase Francci3_0715 172 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 86741470 Common - hypothetical protein Francci3_2782 3 None None None 86742734 Common - Pyridoxal-dependent decarboxylase Francci3_4055 71 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 86742315 Nonpathogen - hypothetical protein Francci3_3634 3 COG5466 COG5466, Predicted small metal-binding protein Function unknown 86741353 Common - metalloendopeptidase, putative, glycoprotease family Francci3_2662 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 86742462 Common - hypothetical protein Francci3_3782 8 None None None 86740045 Common - Adenylylsulfate kinase Francci3_1339 142 COG0529 CysC, Adenylylsulfate kinase and related kinases Inorganic ion transport and metabolism 86743142 Common - Protein-L-isoaspartate(D-aspartate) O-methyltransferase Francci3_4467 137 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 86740762 Nonpathogen - hypothetical protein Francci3_2060 2 None None None 86739586 Nonpathogen - hypothetical protein Francci3_0873 1 None None None 86740207 Common - PilT protein-like Francci3_1502 7 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 86741526 Nonpathogen - McrBC 5-methylcytosine restriction system component-like Francci3_2839 5 COG4268 McrC, McrBC 5-methylcytosine restriction system component Defense mechanisms 86740269 Common - NAD-dependent epimerase/dehydratase Francci3_1564 228 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 86739153 Common - FAD dependent oxidoreductase Francci3_0437 36 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 86743124 Common - UspA Francci3_4449 25 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 86740988 Common - transcriptional regulator, MarR family Francci3_2291 21 COG1846 MarR, Transcriptional regulators Transcription 86742155 Common - polysaccharide biosynthesis protein CapD Francci3_3473 196 COG1086 COG1086, Predicted nucleoside-diphosphate sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 86741401 Common - Pyridoxal-dependent decarboxylase Francci3_2711 101 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 86739071 Nonpathogen - hypothetical protein Francci3_0355 1 None None None 86740437 Nonpathogen - TadE-like Francci3_1732 4 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 86741629 Common - ADP-ribosylation/Crystallin J1 Francci3_2942 14 COG1397 DraG, ADP-ribosylglycohydrolase Posttranslational modification, protein turnover, chaperones 86739964 Common - helix-hairpin-helix DNA-binding, class 1 Francci3_1257 79 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 86742610 Common - hypothetical protein Francci3_3931 14 COG4310 COG4310, Uncharacterized protein conserved in bacteria with an aminopeptidase-like domain General function prediction only 86739563 Nonpathogen - hypothetical protein Francci3_0850 1 None None None 86739851 Nonpathogen - hypothetical protein Francci3_1143 1 None None None 86740955 Common - two component transcriptional regulator, LuxR family Francci3_2258 201 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86739468 Common - RDD Francci3_0755 17 COG1714 COG1714, Predicted membrane protein/domain Function unknown 86743205 Common - hypothetical protein Francci3_4530 15 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86742417 Nonpathogen - hypothetical protein Francci3_3737 2 None None None 86741075 Common - putative serine/threonine kinaseanti-sigma factor Francci3_2379 4 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 86739161 Nonpathogen - putative integral membrane protein Francci3_0446 1 None None None 86742649 Nonpathogen - hypothetical protein Francci3_3970 1 None None None 86742906 Common - Terpene synthase, metal-binding Francci3_4231 12 None None None 86738759 Nonpathogen - hypothetical protein Francci3_0036 2 None None None 86742203 Common - Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine Francci3_3521 170 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 86742333 Common - methylmalonyl-CoA mutase Francci3_3652 110 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 86740548 Common - hypothetical protein Francci3_1843 10 None None None 86741099 Common - Amidase Francci3_2403 77 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 86740586 Nonpathogen - CopG-like DNA-binding Francci3_1881 3 None None None 86741154 Common - Chalcone and stilbene synthases-like Francci3_2458 40 COG3424 BcsA, Predicted naringenin-chalcone synthase Secondary metabolites biosynthesis, transport, and catabolism 86738929 Common - methane/phenol/toluene hydroxylase Francci3_0211 19 None None None 86738754 Common - Uncharacterized membrane-associated protein-like Francci3_0031 167 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 86738891 Common - hypothetical protein Francci3_0170 6 COG0392 COG0392, Predicted integral membrane protein Function unknown 86742377 Common - metal dependent phosphohydrolase Francci3_3696 31 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 86740748 Common - major facilitator superfamily MFS_1 Francci3_2045 199 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86741682 Common - TRAP transporter solute receptor, TAXI family Francci3_2996 32 COG2358 Imp, TRAP-type uncharacterized transport system, periplasmic component General function prediction only 86742847 Common - hypothetical protein Francci3_4170 9 None None None 86742024 Common - hypothetical protein Francci3_3338 39 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 86738846 Nonpathogen - hypothetical protein Francci3_0123 6 None None None 86743087 Common - geranylgeranyl reductase Francci3_4412 38 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 86739257 Common - NADH dehydrogenase subunit G Francci3_0544 194 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 86740619 Common - BFD-like (2Fe-2S)-binding region Francci3_1914 32 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 86739213 Nonpathogen - hypothetical protein Francci3_0499 1 None None None 86739516 Common - 6-phosphogluconate dehydrogenase, NAD-binding Francci3_0803 176 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 86741814 Nonpathogen - hypothetical protein Francci3_3128 1 None None None 86742157 Common - NAD-dependent epimerase/dehydratase Francci3_3475 229 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 86741963 Common - hypothetical protein Francci3_3277 9 COG3516 COG3516, Uncharacterized protein conserved in bacteria Function unknown 86743163 Common - nitrogenase iron protein Francci3_4488 72 COG1348 NifH, Nitrogenase subunit NifH (ATPase) Inorganic ion transport and metabolism 86739280 Common - SecE subunit of protein translocation complex Francci3_0567 8 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 86739342 Common - phosphodiesterase Francci3_0629 91 COG1182 AcpD, Acyl carrier protein phosphodiesterase Lipid metabolism 86742405 Common - threonine synthase Francci3_3724 165 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 86739941 Common - Phosphoglycerate mutase Francci3_1234 142 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 86739768 Common rpsA 30S ribosomal protein S1 Francci3_1057 228 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 86740699 Common - transcriptional regulator, AraC family Francci3_1996 98 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 86740987 Nonpathogen - hypothetical protein Francci3_2290 1 None None None 86738781 Common - pyruvate dehydrogenase Francci3_0058 154 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 86738946 Common - protein of unknown function DUF397 Francci3_0228 6 None None None 86739274 Common - hypothetical protein Francci3_0561 4 None None None 161353752 Common dcd deoxycytidine triphosphate deaminase Francci3_4349 164 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 86741812 Common - Mycobacterium tuberculosis paralogous family 11 Francci3_3126 7 None None None 86742037 Nonpathogen - hypothetical protein Francci3_3351 1 None None None 86739738 Common - hypothetical protein Francci3_1026 2 None None None 86741210 Common - Alcohol dehydrogenase, zinc-binding Francci3_2514 205 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 86739129 Common - hypothetical protein Francci3_0413 13 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 86741297 Common - Sec-independent protein translocase TatC Francci3_2606 205 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 86738788 Common - hypothetical protein Francci3_0065 13 COG5450 COG5450, Transcription regulator of the Arc/MetJ class Transcription 86741573 Nonpathogen - putative regulatory protein Francci3_2886 3 None None None 86742472 Common - Glutaredoxin-like protein GlrX Francci3_3793 30 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 86742690 Common - type I site-specific deoxyribonuclease, HsdR family Francci3_4011 122 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 86743180 Nonpathogen - hypothetical protein Francci3_4505 2 None None None 86740537 Nonpathogen - hypothetical protein Francci3_1832 1 COG4926 PblB, Phage-related protein Function unknown 86741339 Nonpathogen - hypothetical protein Francci3_2648 2 COG5650 COG5650, Predicted integral membrane protein Function unknown 86739348 Common - hypothetical protein Francci3_0635 7 None None None 86742736 Common - L-lysine 6-monooxygenase (NADPH) Francci3_4057 53 COG3486 IucD, Lysine/ornithine N-monooxygenase Secondary metabolites biosynthesis, transport, and catabolism 86740626 Common - transposase IS66 Francci3_1922 47 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739867 Common - hypothetical protein Francci3_1159 7 None None None 86740019 Common - Inositol-1(or 4)-monophosphatase Francci3_1313 172 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 86741178 Nonpathogen - hypothetical protein Francci3_2482 1 None None None 86739838 Nonpathogen - hypothetical protein Francci3_1130 1 None None None 86742067 Common - GTP cyclohydrolase I Francci3_3383 145 COG0780 COG0780, Enzyme related to GTP cyclohydrolase I General function prediction only 86739409 Common - flavoprotein disulfide reductase Francci3_0696 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 86740242 Common - MMPL Francci3_1537 35 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 86741344 Nonpathogen - hypothetical protein Francci3_2653 1 None None None 86741750 Common - hypothetical protein Francci3_3064 2 COG2026 RelE, Cytotoxic translational repressor of toxin-antitoxin stability system Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning 86742009 Nonpathogen - hypothetical protein Francci3_3323 2 None None None 86742310 Common - transcriptional regulator, Crp/Fnr family Francci3_3629 156 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 86740087 Common - peptidyl-prolyl cis-trans isomerase, cyclophilin type Francci3_1381 150 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 86742082 Common - putative replication initiation protein Francci3_3399 5 None None None 86742699 Common - hypothetical protein Francci3_4020 2 None None None 86742400 Common - modification methylase, HemK family Francci3_3719 209 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 86742369 Nonpathogen - hypothetical protein Francci3_3688 1 None None None 86741908 Common - transposase Francci3_3222 11 None None None 86738994 Nonpathogen - hypothetical protein Francci3_0278 4 None None None 86739508 Common - Nitrite reductase (NAD(P)H) large subunit, NirD Francci3_0795 56 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 86742060 Common - alkylhydroperoxidase Francci3_3376 75 COG2128 COG2128, Uncharacterized conserved protein Function unknown 86743140 Nonpathogen - OsmC-like protein Francci3_4465 14 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 86740719 Common - aminotransferase, class I and II Francci3_2016 185 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 86741431 Nonpathogen - hypothetical protein Francci3_2742 1 None None None 86741659 Common - hypothetical protein Francci3_2973 100 COG1540 COG1540, Uncharacterized proteins, homologs of lactam utilization protein B General function prediction only 86738761 Nonpathogen - hypothetical protein Francci3_0038 1 None None None 86741857 Common - ornithine carbamoyltransferase Francci3_3171 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 86740807 Common - putative replication initiation protein Francci3_2106 5 None None None 86739709 Common - alpha/beta hydrolase fold Francci3_0997 8 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86739956 Common - Auxin Efflux Carrier Francci3_1249 19 COG0679 COG0679, Predicted permeases General function prediction only 86739701 Common - Carbamoyl-phosphate synthase L chain, ATP-binding Francci3_0989 229 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 86743066 Common - hypothetical protein Francci3_4391 5 None None None 86743126 Common - acetyl-CoA acetyltransferase Francci3_4451 178 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 86741602 Common - hypothetical protein Francci3_2915 14 None None None 86742923 Common - protein serine/threonine phosphatases Francci3_4248 55 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 86739338 Common - alpha/beta hydrolase fold Francci3_0625 129 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86739725 Nonpathogen - hypothetical protein Francci3_1013 1 None None None 86741116 Common - transcriptional regulator, LysR family Francci3_2420 125 COG0583 LysR, Transcriptional regulator Transcription 86741049 Nonpathogen - hypothetical protein Francci3_2353 1 None None None 86739757 Nonpathogen - putative DNA-binding protein Francci3_1046 1 None None None 86741385 Nonpathogen - dual specificity protein phosphatase Francci3_2695 6 COG2453 CDC14, Predicted protein-tyrosine phosphatase Signal transduction mechanisms 86741767 Common - transcriptional regulator, XRE family Francci3_3081 4 COG2944 COG2944, Predicted transcriptional regulator Transcription 86739780 Common - Hydrogenase expression/formation protein HypE Francci3_1069 114 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 86741171 Common - transcriptional regulator, TetR family Francci3_2475 43 COG1309 AcrR, Transcriptional regulator Transcription 86738795 Common - Poly(3-hydroxybutyrate) depolymerase-like Francci3_0072 27 COG3509 LpqC, Poly(3-hydroxybutyrate) depolymerase Secondary metabolites biosynthesis, transport, and catabolism 86740360 Common - ABC transporter related Francci3_1655 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 86739351 Nonpathogen - hypothetical protein Francci3_0638 1 None None None 86740318 Common - diguanylate cyclase (GGDEF domain) Francci3_1613 175 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 86742583 Common - GreA/GreB family elongation factor Francci3_3904 199 COG0782 GreA, Transcription elongation factor Transcription 86739993 Common - glycosyltransferases-like Francci3_1286 14 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 86741854 Common - argininosuccinate lyase Francci3_3168 227 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 86741301 Common - transcriptional regulator-like Francci3_2610 29 COG2378 COG2378, Predicted transcriptional regulator Transcription 86740767 Common - tryptophan halogenase Francci3_2065 58 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 86740834 Common - membrane-bound metal-dependent hydrolase Francci3_2133 15 None None None 86741893 Common aroB 3-dehydroquinate synthase Francci3_3207 205 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 86740501 Common - hypothetical protein Francci3_1796 4 None None None 86740239 Nonpathogen - hypothetical protein Francci3_1534 1 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 86739789 Common - putative hydrogenase nickel incorporation protein Francci3_1078 4 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 86739180 Common - ABC transporter related Francci3_0465 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 86739615 Nonpathogen - hypothetical protein Francci3_0902 1 None None None 86740102 Nonpathogen - FAD dependent oxidoreductase Francci3_1396 3 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 86739983 Common - pyruvate phosphate dikinase Francci3_1276 235 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 86742918 Common - lipase, putative Francci3_4243 10 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 86741260 Nonpathogen - hypothetical protein Francci3_2569 1 None None None 86740790 Nonpathogen - hypothetical protein Francci3_2089 1 None None None 86743149 Common - pyruvate flavodoxin/ferredoxin oxidoreductase-like Francci3_4474 106 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 86739612 Common - PfkB Francci3_0899 4 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 86742180 Common - putative Lsr2-like protein Francci3_3498 17 None None None 86741735 Nonpathogen - hypothetical protein Francci3_3049 1 None None None 86741033 Nonpathogen - hypothetical protein Francci3_2336 1 None None None 86739301 Common rpsC 30S ribosomal protein S3 Francci3_0588 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 86743073 Common groEL chaperonin GroEL Francci3_4398 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 86741819 Common - Leucyl aminopeptidase Francci3_3133 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 86743112 Common - para-aminobenzoate synthase component II Francci3_4437 236 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 86739176 Common - protein of unknown function DUF349 Francci3_0461 26 None None None 86741421 Nonpathogen - hypothetical protein Francci3_2732 1 None None None 86740956 Common - protein of unknown function DUF574 Francci3_2259 12 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 86742746 Common - transposase, IS4 Francci3_4067 28 None None None 86739187 Common - Ppx/GppA phosphatase Francci3_0472 176 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 86741515 Nonpathogen - hypothetical protein Francci3_2828 1 None None None 86742050 Common - Radical SAM Francci3_3366 117 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 86740109 Common - transglutaminase-like Francci3_1403 97 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 86739016 Common - transposase, IS4 Francci3_0300 28 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86741265 Nonpathogen - hypothetical protein Francci3_2574 1 None None None 86740912 Common - undecaprenyl diphosphate synthase Francci3_2214 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 86742104 Nonpathogen - hypothetical protein Francci3_3421 3 COG4454 COG4454, Uncharacterized copper-binding protein Inorganic ion transport and metabolism 86742560 Common ispH 4-hydroxy-3-methylbut-2-enyl diphosphate reductase Francci3_3881 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 86743189 Common - hypothetical protein Francci3_4514 65 COG4301 COG4301, Uncharacterized conserved protein Function unknown 86743052 Common - L-aspartate oxidase Francci3_4377 220 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 86742753 Nonpathogen - hypothetical protein Francci3_4076 1 None None None 86741520 Common - ABC transporter related Francci3_2833 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 86742758 Common - putative transposase Francci3_4081 46 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 86743131 Nonpathogen - Peptidoglycan-binding domain 1 Francci3_4456 3 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 86742795 Nonpathogen - hypothetical protein Francci3_4118 2 None None None 86740174 Common - FHA domain containing protein Francci3_1468 63 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 86742711 Nonpathogen - hypothetical protein Francci3_4032 1 None None None 86741793 Common - cytochrome c, class I Francci3_3107 43 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 86741452 Common - Methyltransferase type 11 Francci3_2763 4 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 86740621 Nonpathogen - hypothetical protein Francci3_1916 1 None None None 86740799 Nonpathogen - hypothetical protein Francci3_2098 1 None None None 86740874 Common groEL chaperonin GroEL Francci3_2175 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 86739437 Common - ABC-2 Francci3_0724 89 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 86740025 Common - hypothetical protein Francci3_1319 19 None None None 86739948 Common - beta-lactamase-like Francci3_1241 221 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 86740554 Nonpathogen - hypothetical protein Francci3_1849 1 None None None 86740686 Common - D-lactate dehydrogenase (cytochrome) Francci3_1983 202 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 86742347 Nonpathogen - hypothetical protein Francci3_3666 1 None None None 86739244 Common - serine/threonine protein kinase Francci3_0531 147 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86739883 Common - ABC transporter related Francci3_1175 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 86741251 Common - hypothetical protein Francci3_2560 4 None None None 86742640 Common - Glucosamine-1-phosphate N-acetyltransferase Francci3_3961 229 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 86741429 Nonpathogen - hypothetical protein Francci3_2740 1 None None None 86740297 Common - extracellular solute-binding protein, family 1 Francci3_1592 107 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 86743117 Common - glycoside hydrolase 15-related Francci3_4442 69 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 86741009 Nonpathogen - hypothetical protein Francci3_2312 1 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 86742541 Nonpathogen - putative integral membrane protein Francci3_3862 1 None None None 86741675 Nonpathogen - hypothetical protein Francci3_2989 1 None None None 86743211 Common - thioredoxin reductase Francci3_4536 246 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 86739237 Common - response regulator receiver protein Francci3_0524 192 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86742351 Common - Citrate lyase beta subunit-like Francci3_3670 22 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 86741759 Common - oxidoreductase-like Francci3_3073 70 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 86741005 Nonpathogen - hypothetical protein Francci3_2308 2 None None None 86741836 Common - hypothetical protein Francci3_3150 69 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 86740936 Common - 5-oxoprolinase (ATP-hydrolyzing) Francci3_2239 116 COG0145 HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86740737 Common - Protein-L-isoaspartate(D-aspartate) O-methyltransferase Francci3_2034 99 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 86739831 Nonpathogen - transposase Francci3_1122 3 None None None 86740343 Common - Phosphoglycerate kinase Francci3_1638 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 86742942 Common - prolyl-tRNA synthetase Francci3_4267 233 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86740563 Nonpathogen - hypothetical protein Francci3_1858 1 None None None 86741029 Nonpathogen - hypothetical protein Francci3_2332 2 None None None 86740370 Common - SUF system FeS assembly protein Francci3_1665 167 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 86739090 Common - Cystathionine gamma-synthase Francci3_0374 208 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 86740474 Common - cytochrome P450 Francci3_1769 66 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 86742532 Nonpathogen - hypothetical protein Francci3_3853 1 None None None 86742601 Common - Septum formation initiator Francci3_3922 16 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 86741135 Nonpathogen - hypothetical protein Francci3_2439 6 None None None 86743193 Common - replicative DNA helicase Francci3_4518 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 86740661 Nonpathogen - hypothetical protein Francci3_1957 1 None None None 86739100 Common - hypothetical protein Francci3_0384 4 None None None 86740533 Common phhB pterin-4-alpha-carbinolamine dehydratase Francci3_1828 28 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 86742779 Common - Acyl-CoA dehydrogenase Francci3_4102 46 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 86739513 Common - HNH nuclease Francci3_0800 7 None None None 86742395 Common - hypothetical protein Francci3_3714 3 None None None 86742348 Common - hypothetical protein Francci3_3667 10 None None None 86741706 Common - anthranilate synthase component I Francci3_3020 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 86741040 Common - phage integrase Francci3_2344 218 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86739321 Common - 30S ribosomal protein S11 Francci3_0608 248 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 86741502 Common - hypothetical protein Francci3_2815 11 COG2187 COG2187, Uncharacterized protein conserved in bacteria Function unknown 86742046 Common - glycosyl transferase, group 1 Francci3_3362 177 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86742382 Common - NUDIX hydrolase Francci3_3701 72 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 86741125 Common - L-carnitine dehydratase/bile acid-inducible protein F Francci3_2429 116 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 86741648 Nonpathogen - putative integrase Francci3_2961 4 None None None 86739656 Common - FAD linked oxidase-like Francci3_0943 149 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 86741643 Common - putative ATP/GTP binding protein Francci3_2956 26 None None None 86742816 Common - 3-hydroxyacyl-CoA dehydrogenase, NAD-binding Francci3_4139 144 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 86742673 Common - hypothetical protein Francci3_3994 7 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 86739387 Nonpathogen - hypothetical protein Francci3_0674 1 None None None 86739924 Common - hypothetical protein Francci3_1217 43 COG5011 COG5011, Uncharacterized protein conserved in bacteria Function unknown 86739717 Nonpathogen - hypothetical protein Francci3_1005 1 None None None 86740334 Common - glycosyl transferase, family 2 Francci3_1629 61 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 86742639 Common - Stearoyl-CoA 9-desaturase Francci3_3960 70 COG1398 OLE1, Fatty-acid desaturase Lipid metabolism 86742233 Common - hypothetical protein Francci3_3552 11 None None None 86742478 Common - UvrD/REP helicase Francci3_3799 224 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 86740703 Common - hypothetical protein Francci3_2000 18 None None None 86741217 Common - transposase IS66 Francci3_2522 47 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742213 Common - phage integrase Francci3_3532 178 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86741789 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Francci3_3103 14 None None None 86742137 Common - NADPH-dependent FMN reductase Francci3_3454 19 COG0431 COG0431, Predicted flavoprotein General function prediction only 86743154 Common - NifZ Francci3_4479 23 None None None 86741148 Common - aminotransferase, class I and II Francci3_2452 153 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 86740393 Nonpathogen - hypothetical protein Francci3_1688 1 None None None 86739230 Common - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Francci3_0517 152 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 86740969 Common - apolipoprotein N-acyltransferase Francci3_2272 128 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 86741282 Common - Dyp-type peroxidase Francci3_2591 37 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 86743092 Common - phosphoribosylformylglycinamidine synthase II Francci3_4417 233 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 86742889 Common - transposase, IS4 Francci3_4213 43 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741592 Common - aldo/keto reductase Francci3_2905 196 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 86743203 Common - transcriptional regulator, PadR-like family Francci3_4528 16 COG1695 COG1695, Predicted transcriptional regulators Transcription 86742437 Common - diacylglycerol kinase, catalytic region Francci3_3757 12 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 86742770 Common - NUDIX hydrolase Francci3_4093 7 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 86741599 Common - Rossmann fold nucleotide-binding protein-like Francci3_2912 24 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 86738986 Common - conserved hypothetical protein 103 Francci3_0269 169 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 86742593 Nonpathogen - hypothetical protein Francci3_3914 3 None None None 86742961 Common - transcriptional regulator, Crp/Fnr family Francci3_4286 168 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 86740255 Common - 3-hydroxybutyryl-CoA dehydrogenase Francci3_1550 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 86741912 Common - hypothetical protein Francci3_3226 4 None None None 86739029 Common - hypothetical protein Francci3_0313 14 None None None 86740057 Common - protein of unknown function DUF107 Francci3_1351 14 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 86741247 Common - Prevent-host-death protein Francci3_2555 38 COG2161 StbD, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 86742660 Common - serine/threonine protein kinase Francci3_3981 7 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 86740137 Nonpathogen - hypothetical protein Francci3_1431 1 None None None 86740585 Common - hypothetical protein Francci3_1880 4 None None None 86739663 Common - hypothetical protein Francci3_0950 10 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 86740014 Common - UDP-N-acetylglucosamine 2-epimerase Francci3_1308 151 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 86741536 Common - short-chain dehydrogenase/reductase SDR Francci3_2849 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 86740095 Common - 5,10-methylenetetrahydrofolate reductase Francci3_1389 159 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 86739495 Nonpathogen - hypothetical protein Francci3_0782 1 None None None 86739065 Common - ATPase, E1-E2 type Francci3_0349 226 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 86741650 Common - putative transposase, IS891/IS1136/IS1341 Francci3_2963 70 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742278 Common - Chromosome segregation protein SMC Francci3_3597 176 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 86740828 Common - putative transposase Francci3_2127 18 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740150 Nonpathogen - hypothetical protein Francci3_1444 1 COG5416 COG5416, Uncharacterized integral membrane protein Function unknown 86740866 Common - Butyryl-CoA dehydrogenase Francci3_2167 165 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 86739485 Nonpathogen - hypothetical protein Francci3_0772 2 None None None 86739890 Nonpathogen - hypothetical protein Francci3_1182 4 COG5563 COG5563, Predicted integral membrane proteins containing uncharacterized repeats Function unknown 86739625 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Francci3_0912 216 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 86739667 Common - signal transduction histidine kinase regulating citrate/malate metabolism Francci3_0954 39 COG3290 CitA, Signal transduction histidine kinase regulating citrate/malate metabolism Signal transduction mechanisms 86741870 Common - ATPases involved in chromosome partitioning-like Francci3_3184 8 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 86740159 Common - putative transcriptional regulator Francci3_1453 150 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 86741529 Common - DEAD/DEAH box helicase-like Francci3_2842 94 COG1205 COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster General function prediction only 86741441 Common - major facilitator superfamily MFS_1 Francci3_2752 154 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86741936 Nonpathogen - hypothetical protein Francci3_3250 1 None None None 86739683 Common - Twin-arginine translocation pathway signal Francci3_0970 43 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 86740891 Common - protein of unknown function DUF86 Francci3_2193 36 COG2361 COG2361, Uncharacterized conserved protein Function unknown 86741080 Nonpathogen - hypothetical protein Francci3_2384 1 COG1665 COG1665, Uncharacterized protein conserved in archaea Function unknown 86740482 Nonpathogen - cobalamin B12-binding Francci3_1777 7 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 86740752 Common - AMP-dependent synthetase and ligase Francci3_2049 205 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86739639 Common - beta-ketoacyl synthase Francci3_0926 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 86742162 Common - Regulator of polyketide synthase expression-like Francci3_3480 27 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 86742456 Common - alpha/beta hydrolase fold Francci3_3776 190 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86739629 Nonpathogen - hypothetical protein Francci3_0916 1 None None None 86742501 Common - hypothetical protein Francci3_3822 71 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 86742630 Common - peptidyl-tRNA hydrolase Francci3_3951 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 86740304 Common - cytochrome P450 Francci3_1599 87 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 86739897 Common - transposase, IS4 Francci3_1189 28 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86739980 Common - undecaprenyl diphosphate synthase Francci3_1273 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 86740726 Common - hypothetical protein Francci3_2023 8 None None None 86741879 Common - bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase Francci3_3193 232 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 86738744 Common - CRISPR-associated protein, CT1976 Francci3_0021 41 None None None 86742869 Common - putative IS6 family transposase Francci3_4192 21 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742724 Common - protein of unknown function DUF156 Francci3_4045 90 COG1937 COG1937, Uncharacterized protein conserved in bacteria Function unknown 86741566 Nonpathogen - hypothetical protein Francci3_2879 1 None None None 86742360 Common - Trehalose synthase-like Francci3_3679 176 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 86742564 Nonpathogen - hypothetical protein Francci3_3885 1 None None None 86742059 Common - Radical SAM Francci3_3375 8 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 86739543 Common - putative urease accessory protein Francci3_0830 6 COG0829 UreH, Urease accessory protein UreH Posttranslational modification, protein turnover, chaperones 86741773 Common - hypothetical protein Francci3_3087 3 None None None 86742621 Common - Serine acetyltransferase-like Francci3_3942 180 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 86742990 Common - GTP cyclohydrolase I Francci3_4315 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 86740221 Common - transcriptional regulator, MerR family Francci3_1516 60 COG0789 SoxR, Predicted transcriptional regulators Transcription 86740668 Common - protein of unknown function DUF1003 Francci3_1964 33 COG4420 COG4420, Predicted membrane protein Function unknown 86739380 Nonpathogen - hypothetical protein Francci3_0667 1 None None None 86741141 Common - periplasmic sensor signal transduction histidine kinase Francci3_2445 120 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 86738916 Nonpathogen - hypothetical protein Francci3_0197 1 COG4907 COG4907, Predicted membrane protein Function unknown 86740879 Common - protein of unknown function DUF262 Francci3_2180 38 COG1479 COG1479, Uncharacterized conserved protein Function unknown 86741509 Common - delta-1-pyrroline-5-carboxylate dehydrogenase Francci3_2822 218 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 86741666 Common - Precorrin-6y C5,15-methyltransferase, subunit CbiE Francci3_2980 94 COG2242 CobL, Precorrin-6B methylase 2 Coenzyme metabolism 86743179 Common - UvrD/REP helicase Francci3_4504 70 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 86742356 Common - putative tellurium resistance protein TerA Francci3_3675 18 COG4110 COG4110, Uncharacterized protein involved in stress response General function prediction only 86741479 Nonpathogen - response regulator receiver protein Francci3_2792 2 None None None 86739913 Common clpP ATP-dependent Clp protease proteolytic subunit Francci3_1206 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 86741245 Nonpathogen - hypothetical protein Francci3_2552 2 None None None 86741469 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Francci3_2781 91 COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins Amino acid transport and metabolism / General function prediction only 86739920 Nonpathogen - rod shape-determining protein Francci3_1213 2 COG2891 MreD, Cell shape-determining protein Cell envelope biogenesis, outer membrane 86741753 Nonpathogen - hypothetical protein Francci3_3067 1 None None None 86739887 Common - heat shock protein Hsp20 Francci3_1179 128 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 86740404 Nonpathogen - hypothetical protein Francci3_1699 1 None None None 86740823 Common - transcriptional regulator, SARP family Francci3_2122 40 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 86741079 Nonpathogen - 2-phosphoglycerate kinase Francci3_2383 13 COG2074 COG2074, 2-phosphoglycerate kinase Carbohydrate transport and metabolism 86740346 Common - extracellular solute-binding protein, family 5 Francci3_1641 13 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 86742944 Common - ABC-type branched-chain amino acid transport systems periplasmic component-like Francci3_4269 53 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 86743046 Common - phosphoribosylaminoimidazole carboxylase, catalytic subunit Francci3_4371 226 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 86739139 Common - NLP/P60 Francci3_0423 112 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 86740446 Nonpathogen - hypothetical protein Francci3_1741 1 None None None 86743059 Common - metallophosphoesterase Francci3_4384 24 COG1409 Icc, Predicted phosphohydrolases General function prediction only 86738885 Common - Twin-arginine translocation pathway signal Francci3_0164 71 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 86741680 Common - protein of unknown function DUF309 Francci3_2994 7 COG1547 COG1547, Uncharacterized conserved protein Function unknown 86739122 Nonpathogen - hypothetical protein Francci3_0406 1 None None None 86740228 Common - precorrin-4 C11-methyltransferase Francci3_1523 202 COG2875 CobM, Precorrin-4 methylase Coenzyme metabolism 86739643 Common - glycosyltransferase, MGT family Francci3_0930 29 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 86741472 Common - Aldehyde dehydrogenase (NAD+) Francci3_2784 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 86739487 Common - transcriptional regulator, XRE family Francci3_0774 7 COG1396 HipB, Predicted transcriptional regulators Transcription 86740664 Common - site-specific integrase-resolvase-like Francci3_1960 4 COG2452 COG2452, Predicted site-specific integrase-resolvase DNA replication, recombination, and repair 86742167 Common - Propionyl-CoA carboxylase Francci3_3485 187 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 86742577 Common - channel protein, hemolysin III family Francci3_3898 119 COG1272 COG1272, Predicted membrane protein, hemolysin III homolog General function prediction only 86740432 Common - Integrase Francci3_1727 151 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742617 Common - Methyltransferase type 12 Francci3_3938 47 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 86742997 Common - Alcohol dehydrogenase, zinc-binding Francci3_4322 174 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 86739195 Common - phospholipid/glycerol acyltransferase Francci3_0480 50 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 86742221 Common - hypothetical protein Francci3_3540 232 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 86740472 Common - transcriptional regulator, LacI family Francci3_1767 124 COG1609 PurR, Transcriptional regulators Transcription 86742389 Common - ATP synthase F1, gamma subunit Francci3_3708 207 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 86741867 Common rpmI 50S ribosomal protein L35 Francci3_3181 120 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 86739267 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit beta Francci3_0554 118 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 86742288 Common - DEAD/DEAH box helicase-like Francci3_3607 217 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 86742989 Common - ATP-dependent metalloprotease FtsH Francci3_4314 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 86741190 Common - glycoside hydrolase 15-related Francci3_2494 66 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 86742380 Nonpathogen - hypothetical protein Francci3_3699 1 None None None 86740657 Nonpathogen - hypothetical protein Francci3_1953 1 None None None 86738862 Nonpathogen - hypothetical protein Francci3_0139 1 None None None 86739452 Common - phosphoesterase Francci3_0739 12 COG3511 PlcC, Phospholipase C Cell envelope biogenesis, outer membrane 86739580 Common - thiamine S Francci3_0867 43 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 86740601 Nonpathogen - protein of unknown function DUF167 Francci3_1896 1 COG1872 COG1872, Uncharacterized conserved protein Function unknown 86740929 Nonpathogen - peptidase M48, Ste24p Francci3_2232 2 COG4219 MecR1, Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component Transcription / Signal transduction mechanisms 86741311 Common - ATPase Francci3_2620 28 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 86739805 Common - phage integrase Francci3_1095 192 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86742297 Common - hypothetical protein Francci3_3616 12 COG1920 COG1920, Uncharacterized conserved protein Function unknown 86740385 Common - two component transcriptional regulator, LuxR family Francci3_1680 63 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86739089 Nonpathogen - hypothetical protein Francci3_0373 1 None None None 86742876 Nonpathogen - hypothetical protein Francci3_4199 1 None None None 86741851 Common - Uncharacterised conserved protein UCP033563 Francci3_3165 48 COG4198 COG4198, Uncharacterized conserved protein Function unknown 86738732 Common - hypothetical protein Francci3_0009 14 None None None 86741395 Common argS arginyl-tRNA synthetase Francci3_2705 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86738739 Common - acyltransferase 3 Francci3_0016 85 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 86742635 Nonpathogen - hypothetical protein Francci3_3956 1 None None None 86739598 Common - hypothetical protein Francci3_0885 14 COG1179 COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Coenzyme metabolism 86740129 Common - DivIVA Francci3_1423 20 COG3599 DivIVA, Cell division initiation protein Cell division and chromosome partitioning 86739878 Common - GCN5-related N-acetyltransferase Francci3_1170 46 COG0456 RimI, Acetyltransferases General function prediction only 86741496 Common - hypothetical protein Francci3_2809 8 COG1777 COG1777, Predicted transcriptional regulators Transcription 86741944 Common - acyltransferase 3 Francci3_3258 78 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 86742407 Common - diaminopimelate decarboxylase Francci3_3726 217 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 86741664 Common - polysaccharide deacetylase Francci3_2978 106 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 86743076 Common - hypothetical protein Francci3_4401 15 COG2378 COG2378, Predicted transcriptional regulator Transcription 86742555 Common glpX fructose 1,6-bisphosphatase II Francci3_3876 112 COG1494 GlpX, Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins Carbohydrate transport and metabolism 86741120 Common - serine/threonine protein kinase Francci3_2424 75 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86742159 Common - protein tyrosine/serine phosphatase Francci3_3477 30 COG2365 COG2365, Protein tyrosine/serine phosphatase Signal transduction mechanisms 86742709 Common - protein of unknown function DUF574 Francci3_4030 6 None None None 86741073 Common - hypothetical protein Francci3_2377 6 None None None 86741454 Common - binding-protein-dependent transport systems inner membrane component Francci3_2765 201 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 86738808 Common - putative signal transduction histidine kinase Francci3_0085 93 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 86740283 Nonpathogen - hypothetical protein Francci3_1578 1 None None None 86739315 Common secY preprotein translocase subunit SecY Francci3_0602 217 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 86740568 Common - Radical SAM Francci3_1863 90 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 86741384 Nonpathogen - hypothetical protein Francci3_2694 2 None None None 86738875 Common - DNA polymerase Francci3_0152 49 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 86739132 Nonpathogen - hypothetical protein Francci3_0416 2 None None None 86740886 Nonpathogen - hypothetical protein Francci3_2188 1 None None None 86739414 Common - Biotin--acetyl-CoA-carboxylase ligase Francci3_0701 224 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 86741069 Common - Recombinase Francci3_2373 41 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 86739211 Common - hypothetical protein Francci3_0497 6 None None None 86740413 Nonpathogen - hypothetical protein Francci3_1708 1 None None None 86738922 Common - NAD-dependent epimerase/dehydratase Francci3_0203 93 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 86740608 Common - hypothetical protein Francci3_1903 17 None None None 86739733 Nonpathogen - hypothetical protein Francci3_1021 3 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 86740543 Common - 5-formyltetrahydrofolate cyclo-ligase Francci3_1838 21 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 86740857 Common - Phosphonate ABC transporter PhnC, ATP-binding Francci3_2156 249 COG3638 COG3638, ABC-type phosphate/phosphonate transport system, ATPase component Inorganic ion transport and metabolism 86741622 Nonpathogen - hypothetical protein Francci3_2935 3 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 86738815 Common - hypothetical protein Francci3_0092 9 None None None 86740816 Common - extracellular solute-binding protein, family 5 Francci3_2115 187 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 86739446 Nonpathogen - hypothetical protein Francci3_0733 1 None None None 86738977 Common - cold-shock DNA-binding domain protein Francci3_0260 184 COG1278 CspC, Cold shock proteins Transcription 86741038 Common - NUDIX hydrolase Francci3_2342 4 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 86739631 Common - putative serine/threonine kinase anti-sigma factor Francci3_0918 6 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 86741193 Common - putative copper resistance protein D Francci3_2497 32 COG3336 COG3336, Predicted membrane protein Function unknown 86739172 Common - hypothetical protein Francci3_0457 14 None None None 86739601 Nonpathogen - hypothetical protein Francci3_0888 2 None None None 86739419 Common - transcriptional regulator, TetR family Francci3_0706 55 COG1309 AcrR, Transcriptional regulator Transcription 86740884 Nonpathogen - hypothetical protein Francci3_2185 2 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 86742546 Common - putative pterin-4a-carbinolamine dehydratase Francci3_3867 21 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 86741433 Common - putative esterase Francci3_2744 23 COG2382 Fes, Enterochelin esterase and related enzymes Inorganic ion transport and metabolism 86741060 Nonpathogen - hypothetical protein Francci3_2364 1 None None None 86740993 Common - putative bifunctional protein (CbiGH) Francci3_2296 19 None None None 86739396 Common - serine/threonine protein kinase Francci3_0683 151 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86739713 Common - reverse transcriptase Francci3_1001 62 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 86739149 Common - Shikimate 5-dehydrogenase Francci3_0433 152 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 86742748 Common - AAA_3 ATPase associated with various cellular activities Francci3_4071 172 COG0714 COG0714, MoxR-like ATPases General function prediction only 86739276 Common rpmG 50S ribosomal protein L33 Francci3_0563 85 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 86741377 Common - Rieske (2Fe-2S) protein Francci3_2687 69 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 86743174 Common - cyclic nucleotide-binding domain (cNMP-BD) protein Francci3_4499 21 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 86740355 Nonpathogen - hypothetical protein Francci3_1650 4 None None None 86740610 Common - lipolytic enzyme, G-D-S-L Francci3_1905 16 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 86741368 Nonpathogen - hypothetical protein Francci3_2677 1 None None None 86740850 Nonpathogen - putative O-methyltransferase Francci3_2149 3 None None None 86739729 Nonpathogen - hypothetical protein Francci3_1017 1 None None None 86739565 Common - hypothetical protein Francci3_0852 33 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 86739589 Common - putative ATP/GTP binding protein Francci3_0876 39 None None None 86741798 Common - ferric uptake regulator, FUR family Francci3_3112 165 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 86742982 Common - DNA polymerase III subunit delta' Francci3_4307 195 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 86741443 Common - Pyoverdine biosynthesis Francci3_2754 11 COG3207 DIT1, Pyoverdine/dityrosine biosynthesis protein Secondary metabolites biosynthesis, transport, and catabolism 86741129 Common - serine/threonine protein kinase Francci3_2433 115 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86742139 Common - ABC transporter related Francci3_3456 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 86740405 Nonpathogen - hypothetical protein Francci3_1700 1 None None None 86740038 Common - hypothetical protein Francci3_1332 18 None None None 86742506 Common - transcriptional regulator, MarR family Francci3_3827 73 COG1846 MarR, Transcriptional regulators Transcription 86741686 Common - protein of unknown function DUF21 Francci3_3000 212 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 86740093 Common - amine oxidase Francci3_1387 77 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 86741728 Common - acyl-CoA dehydrogenase-like Francci3_3042 162 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 86739183 Common - phosphoglycerate mutase 1 family Francci3_0468 151 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 86742481 Common - methylated-DNA-(protein)-cysteine S-methyltransferase Francci3_3802 35 COG3695 COG3695, Predicted methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 86741360 Common - integral membrane protein Francci3_2669 14 COG5563 COG5563, Predicted integral membrane proteins containing uncharacterized repeats Function unknown 86742865 Common - isopentenyl-diphosphate delta-isomerase Francci3_4188 47 COG1443 Idi, Isopentenyldiphosphate isomerase Lipid metabolism 86740099 Common - glycosyl transferase, family 2 Francci3_1393 58 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86741091 Common - sulfotransferase Francci3_2395 29 None None None 86741557 Common - Cyclopropane-fatty-acyl-phospholipid synthase Francci3_2870 133 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 86742228 Common thyX FAD-dependent thymidylate synthase Francci3_3547 36 COG1351 THY1, Predicted alternative thymidylate synthase Nucleotide transport and metabolism 86741571 Nonpathogen - transposase IS66 Francci3_2884 15 None None None 86739815 Common - transposase, IS4 Francci3_1106 39 None None None 86740206 Nonpathogen - hypothetical protein Francci3_1501 1 None None None 86741411 Nonpathogen - hypothetical protein Francci3_2722 1 None None None 86741736 Common - hypothetical protein Francci3_3050 4 None None None 86742095 Nonpathogen - von Willebrand factor, type A Francci3_3412 5 COG2304 COG2304, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 86740439 Common - type II secretion system protein Francci3_1734 8 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 86738740 Common - CRISPR-associated helicase Cas3, core Francci3_0017 76 COG1203 COG1203, Predicted helicases General function prediction only 86742485 Common - transcriptional regulator, TetR family Francci3_3806 103 COG1309 AcrR, Transcriptional regulator Transcription 86739530 Common - transcriptional regulator, TetR family Francci3_0817 147 COG1309 AcrR, Transcriptional regulator Transcription 86742173 Common moaA molybdenum cofactor biosynthesis protein A Francci3_3491 194 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 86741747 Common - glycosyl transferase, family 2 Francci3_3061 103 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86739825 Common - transcriptional regulator, TetR family Francci3_1116 45 COG1309 AcrR, Transcriptional regulator Transcription 86742331 Common - aminotransferase, class V Francci3_3650 238 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 86740047 Common - Sulfate adenylyltransferase, small subunit Francci3_1341 123 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 86742086 Common - iron permease FTR1 Francci3_3403 95 COG2822 COG2822, Predicted periplasmic lipoprotein involved in iron transport Inorganic ion transport and metabolism 86740717 Common - Drug resistance transporter EmrB/QacA subfamily Francci3_2014 216 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86742317 Nonpathogen - hypothetical protein Francci3_3636 2 None None None 86739049 Common - Rieske (2Fe-2S) protein Francci3_0333 12 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 86742460 Nonpathogen - hypothetical protein Francci3_3780 1 None None None 86742682 Common - transcriptional regulator, BadM/Rrf2 family Francci3_4003 31 COG1959 COG1959, Predicted transcriptional regulator Transcription 86742076 Nonpathogen - hypothetical protein Francci3_3393 1 COG5373 COG5373, Predicted membrane protein Function unknown 86742244 Common - protein of unknown function DUF448 Francci3_3563 30 COG2740 COG2740, Predicted nucleic-acid-binding protein implicated in transcription termination Transcription 86740518 Nonpathogen - hypothetical protein Francci3_1813 1 None None None 86738752 Nonpathogen - hypothetical protein Francci3_0029 1 None None None 86742821 Common - short-chain dehydrogenase-like Francci3_4144 222 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 86738903 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Francci3_0182 47 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 86740571 Nonpathogen - hypothetical protein Francci3_1866 2 None None None 86738848 Nonpathogen - hypothetical protein Francci3_0125 4 None None None 86741544 Common - protein of unknown function, ATP binding Francci3_2857 24 COG2229 COG2229, Predicted GTPase General function prediction only 86742904 Nonpathogen - hypothetical protein Francci3_4229 1 None None None 86740578 Common - transposase, IS4 Francci3_1873 16 None None None 86738823 Nonpathogen - hypothetical protein Francci3_0100 1 COG1157 FliI, Flagellar biosynthesis/type III secretory pathway ATPase Cell motility and secretion / Intracellular trafficking and secretion 86742916 Common - transport system permease protein Francci3_4241 192 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 86740169 Common - Nucleotidyl transferase Francci3_1463 240 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 86740092 Common - AAA_3 ATPase associated with various cellular activities Francci3_1386 178 COG0714 COG0714, MoxR-like ATPases General function prediction only 86741403 Nonpathogen - hypothetical protein Francci3_2713 1 None None None 86740594 Common - glycoside hydrolase 15-related Francci3_1889 67 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 86742657 Common - Acyl-CoA thioesterase-like Francci3_3978 46 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 86739802 Nonpathogen - hypothetical protein Francci3_1092 1 None None None 86741524 Common - binding-protein-dependent transport systems inner membrane component Francci3_2837 133 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 86741696 Nonpathogen - putative integral membrane protein Francci3_3010 2 None None None 86741956 Common - GCN5-related N-acetyltransferase Francci3_3270 97 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 86739142 Common - transcriptional regulator, ArsR family Francci3_0426 119 COG0640 ArsR, Predicted transcriptional regulators Transcription 86742586 Nonpathogen - transcriptional regulator, PadR-like family Francci3_3907 2 COG1695 COG1695, Predicted transcriptional regulators Transcription 86739844 Common - transcriptional regulator, XRE family Francci3_1136 7 COG1396 HipB, Predicted transcriptional regulators Transcription 86740728 Common - transposase, IS4 Francci3_2025 31 None None None 86739303 Common - ribosomal protein L29 Francci3_0590 161 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 86742743 Common - Methyltransferase FkbM Francci3_4064 25 None None None 86739151 Common - transcriptional regulator, MarR family Francci3_0435 61 COG1846 MarR, Transcriptional regulators Transcription 86740199 Nonpathogen - hypothetical protein Francci3_1494 1 None None None 86740492 Nonpathogen - hypothetical protein Francci3_1787 1 None None None 86741727 Common - transcriptional regulator, MarR family Francci3_3041 6 COG1846 MarR, Transcriptional regulators Transcription 86742951 Common - GatB/Yqey Francci3_4276 51 COG1610 COG1610, Uncharacterized conserved protein Function unknown 86739577 Common clpS ATP-dependent Clp protease adaptor protein ClpS Francci3_0864 18 COG2127 COG2127, Uncharacterized conserved protein Function unknown 86739793 Common - hypothetical protein Francci3_1082 15 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 86739621 Common - transcriptional regulator, XRE family Francci3_0908 6 COG1396 HipB, Predicted transcriptional regulators Transcription 86739106 Common - transcriptional regulator, XRE family Francci3_0390 6 COG1476 COG1476, Predicted transcriptional regulators Transcription 86742850 Common - hypothetical protein Francci3_4173 10 None None None 86742022 Nonpathogen - hypothetical protein Francci3_3336 1 None None None 86742393 Nonpathogen - H+-transporting two-sector ATPase, C subunit Francci3_3712 2 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 86741296 Common - DSH-like Francci3_2605 107 COG4581 COG4581, Superfamily II RNA helicase DNA replication, recombination, and repair 86739853 Common - single-strand DNA-binding protein Francci3_1145 95 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 86740329 Nonpathogen - hypothetical protein Francci3_1624 1 None None None 86740758 Nonpathogen - Haloacid dehalogenase-like hydrolase Francci3_2055 2 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 86740114 Nonpathogen - hypothetical protein Francci3_1408 2 None None None 86739344 Nonpathogen - hypothetical protein Francci3_0631 1 None None None 86740760 Common - hypothetical protein Francci3_2058 23 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86743133 Common - adenosine deaminase Francci3_4458 99 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 86741519 Common - transcriptional regulator, RpiR family Francci3_2832 79 COG1737 RpiR, Transcriptional regulators Transcription 86742375 Common - 3-hydroxyacyl-CoA dehydrogenase Francci3_3694 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 86740953 Common - HAD-superfamily hydrolase subfamily IA, variant 3 Francci3_2256 34 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 86741791 Common - cytochrome b/b6-like Francci3_3105 148 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 86742004 Nonpathogen - glycosyl transferase, family 25 Francci3_3318 2 COG3306 COG3306, Glycosyltransferase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 86739953 Nonpathogen - hypothetical protein Francci3_1246 1 None None None 86740456 Common - phosphoribosyltransferase Francci3_1751 29 COG2236 COG2236, Predicted phosphoribosyltransferases General function prediction only 86740745 Common - cytochrome P450 Francci3_2042 59 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 86740262 Common - short-chain dehydrogenase/reductase SDR Francci3_1557 233 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 86743192 Common - Antibiotic biosynthesis monooxygenase Francci3_4517 33 COG1359 COG1359, Uncharacterized conserved protein Function unknown 86739433 Common - glycosyl transferase, group 1 Francci3_0720 140 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86742934 Common - protein of unknown function DUF147 Francci3_4259 28 COG1623 COG1623, Predicted nucleic-acid-binding protein (contains the HHH domain) General function prediction only 86743219 Common - single-stranded nucleic acid binding R3H Francci3_4544 57 COG1847 Jag, Predicted RNA-binding protein General function prediction only 86740998 Common - adenylate/guanylate cyclase Francci3_2301 82 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 86740838 Common - putative alkylated DNA repair protein Francci3_2137 34 COG3145 AlkB, Alkylated DNA repair protein DNA replication, recombination, and repair 86740316 Nonpathogen - hypothetical protein Francci3_1611 1 None None None 86741219 Nonpathogen - hypothetical protein Francci3_2525 1 None None None 86740905 Common - putative transcriptional regulator Francci3_2207 137 COG1733 COG1733, Predicted transcriptional regulators Transcription 86740693 Common - metallophosphoesterase Francci3_1990 20 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 86743039 Common - fructose-bisphosphate aldolase Francci3_4364 98 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 86739551 Common - aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding Francci3_0838 115 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 86740519 Common - Radical SAM Francci3_1814 109 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 86740648 Common - hypothetical protein Francci3_1944 7 None None None 86741230 Common - alpha/beta hydrolase fold Francci3_2537 93 COG2267 PldB, Lysophospholipase Lipid metabolism 86741748 Nonpathogen - hypothetical protein Francci3_3062 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 86739318 Common infA translation initiation factor IF-1 Francci3_0605 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 86742516 Common - hypothetical protein Francci3_3837 16 None None None 86740186 Nonpathogen - hypothetical protein Francci3_1481 1 None None None 86741540 Common - cyclase/dehydrase Francci3_2853 4 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 86739013 Nonpathogen - transposase, IS4 Francci3_0297 8 COG5659 COG5659, FOG: Transposase DNA replication, recombination, and repair 86740976 Common - phospholipid/glycerol acyltransferase Francci3_2279 109 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 86739285 Common rplL 50S ribosomal protein L7/L12 Francci3_0572 207 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 86738955 Common - tyrosinase Francci3_0237 15 None None None 86741512 Common - hypothetical protein Francci3_2825 11 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 86740062 Common - hypothetical protein Francci3_1356 15 None None None 86739865 Common - 4-alpha-glucanotransferase Francci3_1157 116 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 86739044 Common - hypothetical protein Francci3_0328 14 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 86739975 Common - hypothetical protein Francci3_1268 198 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 86742312 Common - branched-chain amino acid aminotransferase Francci3_3631 216 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 86738939 Common - protein of unknown function DUF1469 Francci3_0221 13 None None None 86739054 Common - L-asparaginase II Francci3_0338 46 COG4448 AnsA, L-asparaginase II Amino acid transport and metabolism 86742782 Common - Alcohol dehydrogenase, zinc-binding Francci3_4105 189 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 86739080 Nonpathogen - hypothetical protein Francci3_0364 1 None None None 86739535 Common - Polyprenyl synthetase Francci3_0822 233 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 86741185 Common - cytochrome b/b6-like Francci3_2489 147 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 86741809 Common - putative integral membrane protein Francci3_3123 15 None None None 86741647 Common - Pirin-like Francci3_2960 147 COG1741 COG1741, Pirin-related protein General function prediction only 86739976 Common - CBS Francci3_1269 218 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 86743041 Common - Transglycosylase-like Francci3_4366 14 None None None 86742777 Common - beta-ketoacyl synthase Francci3_4100 199 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86742702 Nonpathogen - hypothetical protein Francci3_4023 1 None None None 86740369 Common - cysteine desulfurases, SufS subfamily Francci3_1664 237 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 86739224 Common - cytochrome c biogenesis protein, transmembrane region Francci3_0511 79 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 86740641 Common - hydrogenase expression/synthesis, HypA Francci3_1937 96 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 86740032 Common - 1-deoxy-D-xylulose-5-phosphate synthase Francci3_1326 222 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 86741994 Nonpathogen - transcriptional regulator, XRE family Francci3_3308 1 None None None 86738784 Common - ferric uptake regulator, FUR family Francci3_0061 185 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 86740021 Common - major facilitator superfamily MFS_1 Francci3_1315 77 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 86740140 Common - hypothetical protein Francci3_1434 36 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 86742261 Common - translation elongation factor Ts Francci3_3580 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 86742619 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Francci3_3940 161 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 86742209 Common - DEAD/DEAH box helicase-like Francci3_3527 135 COG1201 Lhr, Lhr-like helicases General function prediction only 86742423 Common - Methyltransferase type 11 Francci3_3743 42 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 86739745 Common - ABC transporter related Francci3_1034 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 86743105 Common - FHA domain containing protein Francci3_4430 47 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 86741633 Common - alanine dehydrogenase/PNT-like Francci3_2946 166 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 86740294 Common - RNA-binding S4 Francci3_1589 97 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 86739250 Common - geranylgeranyl reductase Francci3_0537 95 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 86740841 Common - UspA Francci3_2140 13 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 86742863 Common - Tetratricopeptide TPR_4 Francci3_4186 48 COG0457 NrfG, FOG: TPR repeat General function prediction only 86740793 Common - beta-ketoacyl synthase Francci3_2092 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86741203 Common - 5-oxoprolinase (ATP-hydrolyzing) Francci3_2507 117 COG0145 HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86739989 Common dnaG DNA primase Francci3_1282 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 86743110 Common - serine/threonine protein kinase Francci3_4435 145 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86741652 Common - flavin-nucleotide-binding protein-like Francci3_2966 27 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 86740489 Nonpathogen - hypothetical protein Francci3_1784 7 None None None 86742471 Common - UvrD/REP helicase Francci3_3792 228 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 86739473 Common - hypothetical protein Francci3_0760 7 None None None 86740690 Common - mandelate racemase/muconate lactonizing enzyme Francci3_1987 98 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 86740353 Common - transaldolase Francci3_1648 59 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 86741568 Common - hypothetical protein Francci3_2881 19 COG4683 COG4683, Uncharacterized protein conserved in bacteria Function unknown 86741895 Common - chorismate synthase Francci3_3209 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 86740872 Common - Chaperone DnaK Francci3_2173 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 86742958 Common - NUDIX hydrolase Francci3_4283 37 None None None 86739699 Common - transcriptional regulator, ArsR family Francci3_0987 57 COG0640 ArsR, Predicted transcriptional regulators Transcription 86740195 Common - adenosylmethionine-8-amino-7-oxononanoate aminotransferase Francci3_1490 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 86739677 Common - glycosyl transferase, family 2 Francci3_0964 126 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86741513 Common - ATP-binding region, ATPase-like Francci3_2826 24 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 86743115 Common - Endoribonuclease L-PSP Francci3_4440 109 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 86740454 Nonpathogen - NUDIX hydrolase Francci3_1749 1 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 86741761 Common thiH thiamine biosynthesis protein ThiH Francci3_3075 54 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 86740157 Nonpathogen - hypothetical protein Francci3_1451 4 None None None 86739962 Nonpathogen - hypothetical protein Francci3_1255 2 COG3247 HdeD, Uncharacterized conserved protein Function unknown 86741278 Common - Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit Francci3_2587 159 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 86739189 Common - UbiE/COQ5 methyltransferase Francci3_0474 121 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86738982 Nonpathogen - hypothetical protein Francci3_0265 1 None None None 86741423 Common - transcriptional regulator, XRE family Francci3_2734 14 COG1476 COG1476, Predicted transcriptional regulators Transcription 86739435 Common - glycosyl transferase, family 2 Francci3_0722 87 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 86742642 Common - tryptophanyl-tRNA synthetase Francci3_3963 231 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86739461 Common - mannose-6-phosphate isomerase, type I Francci3_0748 41 COG1482 ManA, Phosphomannose isomerase Carbohydrate transport and metabolism 86741031 Nonpathogen - hypothetical protein Francci3_2334 1 None None None 86742052 Common - aminoglycoside phosphotransferase Francci3_3368 19 COG3231 Aph, Aminoglycoside phosphotransferase Translation, ribosomal structure and biogenesis 86742830 Common - Alcohol dehydrogenase, zinc-binding Francci3_4153 70 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 86740172 Common - protein of unknown function DUF881 Francci3_1466 24 COG3879 COG3879, Uncharacterized protein conserved in bacteria Function unknown 86741164 Common - carbon starvation protein CstA Francci3_2468 108 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 86739480 Common - preprotein translocase subunit SecA Francci3_0767 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 86741262 Common - Recombinase Francci3_2571 9 None None None 86740367 Common - Rieske (2Fe-2S) protein Francci3_1662 83 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 86739648 Common - hypothetical protein Francci3_0935 10 COG3786 COG3786, Uncharacterized protein conserved in bacteria Function unknown 86739400 Common - DNA-3-methyladenine glycosylase I Francci3_0687 132 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 86742550 Common - translation-associated GTPase Francci3_3871 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 86742755 Common - putative integral membrane export protein Francci3_4078 20 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 86742793 Common - ribosomal protein L11 Francci3_4116 248 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 86740002 Common - hypothetical protein Francci3_1296 2 None None None 86739150 Common - 3-dehydroquinate synthase Francci3_0434 206 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 86742353 Common - hypothetical protein Francci3_3672 3 None None None 86741704 Nonpathogen - hypothetical protein Francci3_3018 1 None None None 86742258 Common - hypothetical protein Francci3_3577 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 86740688 Nonpathogen - hypothetical protein Francci3_1985 1 None None None 86742275 Common - ribosomal protein S16 Francci3_3594 213 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 86740836 Common - lipoate-protein ligase B Francci3_2135 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 86740085 Common - transcriptional regulator, XRE family Francci3_1379 5 COG1476 COG1476, Predicted transcriptional regulators Transcription 86739242 Common - cobalamin (vitamin B12) biosynthesis CbiX protein Francci3_0529 64 COG2138 COG2138, Uncharacterized conserved protein Function unknown 86742451 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Francci3_3771 226 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 86742671 Common - putative regulatory protein Francci3_3992 6 None None None 86740126 Common - Protein of unknown function UPF0001 Francci3_1420 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 86742342 Common - Endonuclease/exonuclease/phosphatase Francci3_3661 42 COG3021 COG3021, Uncharacterized protein conserved in bacteria Function unknown 86742696 Common - transcriptional regulator, XRE family Francci3_4017 4 COG1396 HipB, Predicted transcriptional regulators Transcription 86742074 Nonpathogen - hypothetical protein Francci3_3391 1 None None None 86742345 Common - Alpha-glucan phosphorylase Francci3_3664 142 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 86740735 Nonpathogen - hypothetical protein Francci3_2032 6 None None None 86741336 Common - Phosphoglycerate mutase Francci3_2645 102 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 86738908 Common - 2OG-Fe(II) oxygenase Francci3_0188 46 COG3491 PcbC, Isopenicillin N synthase and related dioxygenases General function prediction only 86739885 Nonpathogen - putative secreted protein Francci3_1177 5 None None None 86742362 Common - glycogen branching enzyme Francci3_3681 148 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 86741306 Common - Magnesium-translocating P-type ATPase Francci3_2615 205 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 86741546 Common - hypothetical protein Francci3_2859 10 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 86743018 Common - hypothetical protein Francci3_4343 10 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 86741248 Common - Addiction module toxin, Txe/YoeB Francci3_2556 52 COG4115 COG4115, Uncharacterized protein conserved in bacteria Function unknown 86740730 Common - Pyruvate:ferredoxin (flavodoxin) oxidoreductase Francci3_2027 117 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 86742458 Common - aminotransferase class-III Francci3_3778 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 86740302 Nonpathogen - hypothetical protein Francci3_1597 1 None None None 86739361 Common - PGAP1-like Francci3_0648 28 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 86738948 Nonpathogen - hypothetical protein Francci3_0230 1 None None None 86740325 Common - Extracellular ligand-binding receptor Francci3_1620 130 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 86741405 Nonpathogen - hypothetical protein Francci3_2715 3 None None None 86741631 Common - Aldehyde dehydrogenase (NAD+) Francci3_2944 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 86742197 Common - diguanylate phosphodiesterase (EAL domain) Francci3_3515 156 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 86741884 Common carB carbamoyl phosphate synthase large subunit Francci3_3198 235 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 86742980 Common - DNA topoisomerase Francci3_4305 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 86740244 Common - Twin-arginine translocation pathway signal Francci3_1539 16 None None None 86741810 Common - aldo/keto reductase Francci3_3124 197 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 86739731 Nonpathogen - hypothetical protein Francci3_1019 3 None None None 86742534 Common - dipeptidase Francci3_3855 178 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 86742084 Nonpathogen - hypothetical protein Francci3_3401 1 COG0546 Gph, Predicted phosphatases General function prediction only 86738786 Nonpathogen - hypothetical protein Francci3_0063 1 None None None 86741042 Nonpathogen - hypothetical protein Francci3_2346 1 None None None 86741600 Common - ferredoxin-dependent glutamate synthase Francci3_2913 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 86740300 Common - ABC transporter related Francci3_1595 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 86743099 Common - hypothetical protein Francci3_4424 25 None None None 86740631 Nonpathogen - phosphopantetheine-binding Francci3_1927 1 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86740162 Common - cytidylate kinase Francci3_1456 207 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 86742035 Nonpathogen - hypothetical protein Francci3_3349 1 None None None 86741342 Nonpathogen - hypothetical protein Francci3_2651 1 None None None 86740981 Nonpathogen - TM2 Francci3_2284 1 None None None 86742651 Common - glycoside hydrolase 15-related Francci3_3972 69 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 86739206 Common - methionyl-tRNA synthetase Francci3_0491 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86742307 Common - 5-carboxymethyl-2-hydroxymuconate delta-isomerase Francci3_3626 180 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 86739511 Common - ABC transporter related Francci3_0798 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 86740773 Common - aspartate kinase Francci3_2071 233 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 86742680 Nonpathogen - hypothetical protein Francci3_4001 2 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86740327 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) Francci3_1622 169 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 86742264 Common - phage integrase Francci3_3583 220 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86743027 Common - Chaperone DnaK Francci3_4352 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 86740527 Nonpathogen - hypothetical protein Francci3_1822 7 None None None 86742738 Common - glutamine synthetase, catalytic region Francci3_4059 222 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 86740805 Nonpathogen - hypothetical protein Francci3_2104 1 None None None 86741114 Common - binding-protein-dependent transport systems inner membrane component Francci3_2418 104 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 86742424 Common - UvrD/REP helicase Francci3_3744 233 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 86742887 Common - transposase, IS4 Francci3_4211 26 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86741267 Nonpathogen - hypothetical protein Francci3_2576 1 None None None 86742419 Nonpathogen - hypothetical protein Francci3_3739 1 None None None 86741227 Common - transposase IS66 Francci3_2533 47 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 86738989 Nonpathogen - hypothetical protein Francci3_0273 1 None None None 86741527 Common - AAA_5 ATPase associated with various cellular activities Francci3_2840 45 COG1401 McrB, GTPase subunit of restriction endonuclease Defense mechanisms 86741256 Common - transcriptional regulator, AbrB family Francci3_2565 2 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 86741587 Common - putative integral membrane protein Francci3_2900 9 None None None 86740971 Common - transcriptional regulator, AsnC family Francci3_2274 151 COG1522 Lrp, Transcriptional regulators Transcription 86740787 Common - Drug resistance transporter EmrB/QacA subfamily Francci3_2086 183 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86743014 Common - hypothetical protein Francci3_4339 7 None None None 86740628 Common - hypothetical protein Francci3_1924 11 None None None 86742062 Common - tRNA-guanine transglycosylases, various specificities Francci3_3378 222 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 86742689 Common - protein of unknown function DUF45 Francci3_4010 143 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 86741906 Common - putative transcriptional regulator Francci3_3220 9 COG1733 COG1733, Predicted transcriptional regulators Transcription 86741942 Common - serine/threonine protein kinase with WD40 repeats Francci3_3256 152 COG2319 COG2319, FOG: WD40 repeat General function prediction only 86739778 Nonpathogen - hypothetical protein Francci3_1067 2 None None None 86739703 Common - acyl transferase region Francci3_0991 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 86741609 Common - formate dehydrogenase, subunit FdhD Francci3_2922 5 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 86742192 Common - LexA repressor Francci3_3510 172 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 86743065 Common - Glu/Leu/Phe/Val dehydrogenase Francci3_4390 178 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 86739727 Nonpathogen - putative DNA-binding protein Francci3_1015 1 None None None 86738950 Nonpathogen - FMN-binding Francci3_0232 5 COG3976 COG3976, Uncharacterized protein conserved in bacteria Function unknown 86739335 Common - alanine racemase Francci3_0622 199 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 86742666 Common - phosphoribosyltransferase Francci3_3987 72 COG1926 COG1926, Predicted phosphoribosyltransferases General function prediction only 86741212 Common - amidohydrolase 2 Francci3_2516 23 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 86742524 Nonpathogen - 4Fe-4S ferredoxin, iron-sulfur binding Francci3_3845 3 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 86740250 Common - hypothetical protein Francci3_1545 10 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 86740721 Common - NAD-binding protein, putative Francci3_2018 56 COG2910 COG2910, Putative NADH-flavin reductase General function prediction only 86741827 Common - RDD Francci3_3141 18 COG1714 COG1714, Predicted membrane protein/domain Function unknown 86738768 Common - Glucose-6-phosphate isomerase Francci3_0045 193 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 86740391 Nonpathogen - Recombinase Francci3_1686 2 None None None 86742845 Common dnaE DNA polymerase III subunit alpha Francci3_4168 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 86738996 Common - CMP/dCMP deaminase, zinc-binding Francci3_0280 210 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 86739545 Common ureC urease subunit alpha Francci3_0832 96 COG0804 UreC, Urea amidohydrolase (urease) alpha subunit Amino acid transport and metabolism 86741313 Common - transcriptional regulator, AraC family Francci3_2622 44 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 86738969 Common - Taurine dioxygenase Francci3_0252 47 COG2175 TauD, Probable taurine catabolism dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 86738988 Nonpathogen - hypothetical protein Francci3_0272 1 None None None 86743151 Common - UBA/THIF-type NAD/FAD binding fold Francci3_4476 201 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 86739720 Common - MOSC Francci3_1008 26 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 86739623 Common - Recombinase Francci3_0910 69 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 86740237 Common - periplasmic binding protein/LacI transcriptional regulator Francci3_1532 123 COG1609 PurR, Transcriptional regulators Transcription 86741105 Common - hypothetical protein Francci3_2409 35 COG2321 COG2321, Predicted metalloprotease General function prediction only 86739033 Common - pyruvate carboxylase Francci3_0317 233 COG1038 PycA, Pyruvate carboxylase Energy production and conversion 86740070 Common - Phosphatidyl-myo-inositol alpha-mannosyltransferase Francci3_1364 192 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86742585 Common - von Willebrand factor, type A Francci3_3906 21 COG4867 COG4867, Uncharacterized protein with a von Willebrand factor type A (vWA) domain General function prediction only 86741877 Common - primosome assembly protein PriA Francci3_3191 195 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 86742373 Common - hypothetical protein Francci3_3692 13 None None None 86739259 Common - NADH dehydrogenase subunit I Francci3_0546 191 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 86740877 Nonpathogen - hypothetical protein Francci3_2178 1 None None None 86740583 Nonpathogen - hypothetical protein Francci3_1878 1 None None None 86742567 Nonpathogen - hypothetical protein Francci3_3888 1 None None None 86742325 Common gatA aspartyl/glutamyl-tRNA amidotransferase subunit A Francci3_3644 222 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 86742439 Common - transcription factor WhiB Francci3_3759 19 None None None 86739063 Common - acyltransferase 3 Francci3_0347 42 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 86740541 Common - protein of unknown function DUF574 Francci3_1836 12 None None None 86742548 Common - hypothetical protein Francci3_3869 8 COG3503 COG3503, Predicted membrane protein Function unknown 86740411 Nonpathogen - hypothetical protein Francci3_1706 1 None None None 86740788 Common - hypothetical protein Francci3_2087 61 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 86739669 Nonpathogen - hypothetical protein Francci3_0956 1 None None None 86742378 Nonpathogen - hypothetical protein Francci3_3697 1 None None None 86739872 Common - glycosyl transferase, family 2 Francci3_1164 208 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86740921 Nonpathogen - hypothetical protein Francci3_2224 3 None None None 86742766 Common - transcriptional coactivator/pterin dehydratase Francci3_4089 26 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 86742189 Common - Ribonucleoside diphosphate reductase, B12-dependent Francci3_3507 198 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 86739665 Common - putative helicase Francci3_0952 33 COG3973 COG3973, Superfamily I DNA and RNA helicases General function prediction only 86741934 Common - 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate Francci3_3248 59 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 86741618 Common - beta-ketoacyl synthase Francci3_2931 210 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 86739627 Nonpathogen - DoxX Francci3_0914 3 COG2259 COG2259, Predicted membrane protein Function unknown 86740379 Common - putative transcriptional regulator Francci3_1674 10 None None None 86739389 Common - short-chain dehydrogenase/reductase SDR Francci3_0676 237 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 86741534 Nonpathogen - Antibiotic biosynthesis monooxygenase Francci3_2847 2 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 86739385 Common - transposase, IS4 Francci3_0672 28 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86742150 Common - succinate dehydrogenase/fumarate reductase iron-sulfur subunit Francci3_3467 164 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 86741593 Nonpathogen - hypothetical protein Francci3_2906 1 COG5405 HslV, ATP-dependent protease HslVU (ClpYQ), peptidase subunit Posttranslational modification, protein turnover, chaperones 86741988 Nonpathogen - hypothetical protein Francci3_3302 1 None None None 86740938 Nonpathogen - hypothetical protein Francci3_2241 1 COG1584 COG1584, Predicted membrane protein Function unknown 86740214 Nonpathogen - hypothetical protein Francci3_1509 1 None None None 86742291 Nonpathogen - hypothetical protein Francci3_3610 1 None None None 86740894 Nonpathogen - hypothetical protein Francci3_2196 3 None None None 86740116 Common - UDP-N-acetylmuramyl-tripeptide synthetases Francci3_1410 209 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 86740507 Nonpathogen - hypothetical protein Francci3_1802 1 None None None 86741362 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding Francci3_2671 8 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 86741143 Common - ABC transporter related Francci3_2447 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 86742448 Common - RNA polymerase sigma factor RpoE Francci3_3768 174 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 86739998 Nonpathogen - hypothetical protein Francci3_1292 1 None None None 86739899 Common - hypothetical protein Francci3_1191 2 None None None 86742430 Common - Alcohol dehydrogenase, zinc-binding Francci3_3750 164 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 86743084 Nonpathogen - hypothetical protein Francci3_4409 1 None None None 86738777 Nonpathogen - hypothetical protein Francci3_0054 1 None None None 86739524 Common - transcriptional regulator, PadR-like family Francci3_0811 30 COG1695 COG1695, Predicted transcriptional regulators Transcription 86740636 Common - AMP-dependent synthetase and ligase Francci3_1932 192 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 86739373 Common - geranylgeranyl reductase Francci3_0660 55 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 86741489 Common - putative transcriptional regulator, Fis family Francci3_2802 21 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 86742805 Nonpathogen - hypothetical protein Francci3_4128 1 None None None 86739493 Common - type II secretion system protein Francci3_0780 8 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 86738957 Nonpathogen - hypothetical protein Francci3_0239 1 None None None 86739459 Common - transcription factor WhiB Francci3_0746 19 None None None 86742623 Common - FkbH domain Francci3_3944 28 COG3882 FkbH, Predicted enzyme involved in methoxymalonyl-ACP biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 86742241 Common rbfA ribosome-binding factor A Francci3_3560 155 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 86741831 Common - Glutamate--ammonia ligase Francci3_3145 229 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 86740222 Common - aldo/keto reductase Francci3_1517 202 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 86738746 Common - CRISPR-associated protein Cas1 Francci3_0023 52 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 86741986 Nonpathogen - hypothetical protein Francci3_3300 1 None None None 86741355 Common - cytochrome P450 Francci3_2664 86 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 86740484 Common - putative signal transduction histidine kinase Francci3_1779 5 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 86742603 Common - peptidase S49 Francci3_3924 189 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 86743071 Nonpathogen - Haloacid dehalogenase-like hydrolase, type 3 Francci3_4396 3 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 86741995 Nonpathogen - hypothetical protein Francci3_3309 1 None None None 86739946 Common - short-chain dehydrogenase/reductase SDR Francci3_1239 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 86741284 Nonpathogen - hypothetical protein Francci3_2593 1 None None None 86739096 Common - ABC-type branched-chain amino acid transport systems periplasmic component-like Francci3_0380 8 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 86742979 Common hppA membrane-bound proton-translocating pyrophosphatase Francci3_4304 98 COG3808 OVP1, Inorganic pyrophosphatase Energy production and conversion 86742301 Common leuD isopropylmalate isomerase small subunit Francci3_3620 211 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 86739323 Common - DNA-directed RNA polymerase subunit alpha Francci3_0610 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 86739450 Common - Nucleotidyl transferase Francci3_0737 236 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 86740279 Common - glycosyl transferase, group 1 Francci3_1574 95 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86740662 Common - Integrase Francci3_1958 125 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741641 Common - bacteriophage (phiC31) resistance gene PglY Francci3_2954 9 None None None 86741949 Common - Integrase Francci3_3263 63 COG2826 Tra8, Transposase and inactivated derivatives, IS30 family DNA replication, recombination, and repair 86742235 Common - processing peptidase Francci3_3554 199 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 86739961 Common - protein of unknown function DUF159 Francci3_1254 110 COG2135 COG2135, Uncharacterized conserved protein Function unknown 86741800 Common trpD anthranilate phosphoribosyltransferase Francci3_3114 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 86740960 Nonpathogen - hypothetical protein Francci3_2263 1 None None None 86740134 Nonpathogen - hypothetical protein Francci3_1428 1 None None None 86743195 Common rpsR 30S ribosomal protein S18 Francci3_4520 209 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 86742250 Common - binding-protein-dependent transport systems inner membrane component Francci3_3569 156 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 86742976 Common - DEAD/DEAH box helicase-like Francci3_4301 121 COG1205 COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster General function prediction only 86740914 Common - protein of unknown function DUF1360 Francci3_2216 5 None None None 86742891 Nonpathogen - hypothetical protein Francci3_4215 2 None None None 86740274 Common - O-antigen polymerase Francci3_1569 4 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 86743217 Common gidB glucose-inhibited division protein B Francci3_4542 151 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 86740077 Common ruvB Holliday junction DNA helicase B Francci3_1371 219 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 86742358 Common - stress protein Francci3_3677 29 COG2310 TerZ, Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 Signal transduction mechanisms 86741500 Common - extracellular solute-binding protein, family 3 Francci3_2813 91 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 86742898 Common - insertion element IS466S transposase Francci3_4223 19 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742044 Common - glucose-methanol-choline oxidoreductase Francci3_3360 73 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 86743156 Common - protein of unknown function DUF683 Francci3_4481 15 COG5420 COG5420, Uncharacterized conserved small protein containing a coiled-coil domain Function unknown 86741482 Common - copper resistance D Francci3_2795 19 COG3336 COG3336, Predicted membrane protein Function unknown 86738734 Common - Methyltransferase type 11 Francci3_0011 150 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86739926 Nonpathogen - hypothetical protein Francci3_1219 1 None None None 86740055 Common - Malto-oligosyltrehalose synthase Francci3_1349 69 COG3280 TreY, Maltooligosyl trehalose synthase Carbohydrate transport and metabolism 86739020 Common - putative signal transduction histidine kinase Francci3_0304 22 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 86739908 Common - conserved hypothetical protein 2SC10A7.05c Francci3_1201 11 None None None 86741885 Common - carbamoyl phosphate synthase small subunit Francci3_3199 232 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 86740009 Common - Methyltransferase FkbM Francci3_1303 111 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 86740016 Common - glycosyl transferase, group 1 Francci3_1310 8 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86739715 Common - protein of unknown function DUF574 Francci3_1003 12 None None None 86741684 Common - hypothetical protein Francci3_2998 7 None None None 86741976 Nonpathogen - hypothetical protein Francci3_3290 1 None None None 86742495 Common - protein of unknown function DUF1003 Francci3_3816 45 COG4420 COG4420, Predicted membrane protein Function unknown 86738810 Nonpathogen - dehydrogenases and related proteins-like Francci3_0087 3 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 86738838 Common - transposase, IS4 Francci3_0115 25 None None None 86740701 Common - O-succinylhomoserine sulfhydrylase Francci3_1998 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 86738964 Common - hypothetical protein Francci3_0247 5 None None None 86741910 Nonpathogen - hypothetical protein Francci3_3224 1 None None None 86742921 Common - RNA methyltransferase TrmH, group 3 Francci3_4246 210 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 86739934 Common proA gamma-glutamyl phosphate reductase Francci3_1227 187 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 86739182 Common - glycine cleavage T protein (aminomethyl transferase) Francci3_0467 48 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 86740253 Nonpathogen - hypothetical protein Francci3_1548 1 None None None 86743221 Common - protein of unknown function DUF37 Francci3_4546 4 COG0759 COG0759, Uncharacterized conserved protein Function unknown 86742215 Nonpathogen - hypothetical protein Francci3_3534 1 None None None 86738851 Common - protein of unknown function DUF955 Francci3_0128 36 COG2856 COG2856, Predicted Zn peptidase Amino acid transport and metabolism 86741023 Common - major intrinsic protein Francci3_2326 45 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 86743090 Common - putative serine/threonine kinase anti-sigma factor Francci3_4415 20 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 86741674 Common - Peptidoglycan-binding domain 1 Francci3_2988 16 COG3409 COG3409, Putative peptidoglycan-binding domain-containing protein Cell envelope biogenesis, outer membrane 86742204 Common - Amino acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine Francci3_3522 173 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 86742589 Common - alpha/beta hydrolase fold Francci3_3910 92 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86739533 Common - Squalene/phytoene synthase Francci3_0820 111 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 86743043 Common - adenylosuccinate synthetase Francci3_4368 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 86739375 Common - 2',5' RNA ligase Francci3_0662 9 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 86742852 Common - nuclear export factor GLE1 Francci3_4175 31 COG4549 COG4549, Uncharacterized protein conserved in bacteria Function unknown 86741580 Nonpathogen - hypothetical protein Francci3_2893 2 COG0122 AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 86740410 Nonpathogen - hypothetical protein Francci3_1705 2 None None None 86739950 Common - transcriptional regulator, TetR family Francci3_1243 42 COG1309 AcrR, Transcriptional regulator Transcription 86740339 Common - hypothetical protein Francci3_1634 140 COG1660 COG1660, Predicted P-loop-containing kinase General function prediction only 86740053 Common - Malto-oligosyltrehalose trehalohydrolase Francci3_1347 162 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 86742193 Common - Small GTP-binding protein domain Francci3_3511 225 COG2262 HflX, GTPases General function prediction only 86740146 Common - hypothetical protein Francci3_1440 8 None None None 86741824 Common - lipoyl synthase Francci3_3138 190 COG0320 LipA, Lipoate synthase Coenzyme metabolism 86742760 Common - Transposase and inactivated derivatives-like Francci3_4083 46 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 86738725 Common - chromosomal replication initiator protein DnaA Francci3_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 86740272 Common - glycosyl transferase, family 2 Francci3_1567 154 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86743108 Common - cell cycle protein Francci3_4433 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 86740562 Common - hypothetical protein Francci3_1857 30 COG1569 COG1569, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 86743006 Common - hypothetical protein Francci3_4331 9 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 86741183 Common - Transketolase Francci3_2487 217 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 86741271 Nonpathogen - hypothetical protein Francci3_2580 6 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 86742536 Common - N-succinyldiaminopimelate aminotransferase Francci3_3857 234 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 86740462 Common - hypothetical protein Francci3_1757 4 None None None 86741458 Common - two component transcriptional regulator, LuxR family Francci3_2769 18 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86740819 Common - Oligopeptide/dipeptide ABC transporter, ATP-binding protein-like Francci3_2118 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 86742006 Common - putative hydrolase Francci3_3320 11 COG2267 PldB, Lysophospholipase Lipid metabolism 86739743 Nonpathogen - Excisionase/Xis, DNA-binding Francci3_1031 2 COG2452 COG2452, Predicted site-specific integrase-resolvase DNA replication, recombination, and repair 86740008 Common - hypothetical protein Francci3_1302 19 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86740178 Common - daunorubicin resistance ABC transporter ATP-binding subunit Francci3_1472 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 86739398 Common deoA thymidine phosphorylase Francci3_0685 118 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 86741978 Common - PilT protein-like Francci3_3292 3 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 86741839 Common - Tyrosine recombinase XerD Francci3_3153 225 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86741130 Nonpathogen - hypothetical protein Francci3_2434 6 COG4226 HicB, Uncharacterized protein encoded in hypervariable junctions of pilus gene clusters Function unknown 86740065 Common - sporulation and cell division protein SsgA Francci3_1359 8 None None None 86740962 Nonpathogen - hypothetical protein Francci3_2265 1 None None None 86739260 Common - NADH dehydrogenase subunit J Francci3_0547 116 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 86741909 Common - transposase Francci3_3223 31 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739283 Common - ribosomal protein L1 Francci3_0570 233 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 86741902 Common - hypothetical protein Francci3_3216 12 None None None 86739123 Common - phage integrase Francci3_0407 38 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 86742707 Common - alpha/beta hydrolase fold Francci3_4028 125 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86741830 Common - Glutamate-ammonia-ligase adenylyltransferase Francci3_3144 119 COG1391 GlnE, Glutamine synthetase adenylyltransferase Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms 86741213 Common - monooxygenase component MmoB/DmpM Francci3_2517 9 None None None 86741549 Nonpathogen - hypothetical protein Francci3_2862 1 None None None 86742515 Common - Leucyl aminopeptidase Francci3_3836 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 86742318 Common - D-3-phosphoglycerate dehydrogenase Francci3_3637 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 86742867 Common - hypothetical protein Francci3_4190 71 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739042 Nonpathogen - hypothetical protein Francci3_0326 2 None None None 86739880 Common - 2,5-didehydrogluconate reductase Francci3_1172 179 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 86740041 Common - protoporphyrinogen oxidase Francci3_1335 54 COG1232 HemY, Protoporphyrinogen oxidase Coenzyme metabolism 86742390 Common - F0F1 ATP synthase subunit alpha Francci3_3709 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 86740906 Common - YceI Francci3_2208 119 COG2353 COG2353, Uncharacterized conserved protein Function unknown 86738925 Common - hypothetical protein Francci3_0207 10 COG4124 ManB, Beta-mannanase Carbohydrate transport and metabolism 86742263 Common - peptidase M23B Francci3_3582 18 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 86739094 Common - ABC transporter related Francci3_0378 246 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 86742871 Common - Methyltransferase type 12 Francci3_4194 113 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 86742774 Common - beta-lactamase-like Francci3_4097 73 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 86740640 Common - hypothetical protein Francci3_1936 8 None None None 86740679 Common - Amino acid adenylation Francci3_1976 205 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 86742800 Nonpathogen - hypothetical protein Francci3_4123 1 None None None 86743165 Nonpathogen - hypothetical protein Francci3_4490 1 None None None 86738880 Nonpathogen - hypothetical protein Francci3_0159 3 None None None 86739765 Common - acyltransferase 3 Francci3_1054 86 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 86738906 Common - binding-protein-dependent transport systems inner membrane component Francci3_0186 211 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 86740714 Common - hypothetical protein Francci3_2011 3 COG5479 COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis Cell envelope biogenesis, outer membrane 86741634 Common - NAD/NADP transhydrogenase alpha subunit-like Francci3_2947 115 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 86739827 Common - major facilitator superfamily MFS_1 Francci3_1118 188 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86742939 Common - Phosphate ABC transporter, permease protein PstC Francci3_4264 224 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 86743177 Common - putative signal-transduction protein with CBS domains Francci3_4502 197 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 86740825 Common - transposase IS116/IS110/IS902 Francci3_2124 79 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739575 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Francci3_0862 168 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 86742283 Common - fatty acid synthesis plsX protein Francci3_3602 172 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 86739052 Nonpathogen - hypothetical protein Francci3_0336 1 None None None 86738932 Nonpathogen - monooxygenase component MmoB/DmpM Francci3_0214 8 None None None 86741158 Common - ABC transporter related Francci3_2462 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 86742071 Common - phage integrase Francci3_3388 31 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 86739227 Common - hypothetical protein Francci3_0514 7 None None None 86743030 Common - transcriptional regulator, MerR family Francci3_4355 53 COG0789 SoxR, Predicted transcriptional regulators Transcription 86740996 Common - von Willebrand factor, type A Francci3_2299 72 COG1239 ChlI, Mg-chelatase subunit ChlI Coenzyme metabolism 86740119 Common - UDP-N-acetylmuramoylalanine--D-glutamate ligase Francci3_1413 193 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 86739874 Nonpathogen - hypothetical protein Francci3_1166 2 None None None 86739829 Nonpathogen - putative actinorhodin transporter Francci3_1120 1 None None None 86742370 Common - sigma-24 Francci3_3689 76 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 86743020 Common - glycosyl transferase, group 1 Francci3_4345 33 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86740167 Common - NLP/P60 Francci3_1461 131 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 86738813 Nonpathogen - hypothetical protein Francci3_0090 16 None None None 86740444 Nonpathogen - putative ATP/GTP-binding protein Francci3_1739 3 None None None 86739693 Common - hypothetical protein Francci3_0980 13 COG3222 COG3222, Uncharacterized protein conserved in bacteria Function unknown 86740766 Nonpathogen - hypothetical protein Francci3_2064 3 None None None 86742352 Nonpathogen - hypothetical protein Francci3_3671 6 COG4124 ManB, Beta-mannanase Carbohydrate transport and metabolism 86741924 Common - hypothetical protein Francci3_3238 4 None None None 86741350 Common - luciferase-like Francci3_2659 60 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 86741860 Common argJ bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein Francci3_3174 167 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 86742466 Common - hypothetical protein Francci3_3786 23 COG5282 COG5282, Uncharacterized conserved protein Function unknown 86741016 Nonpathogen - hypothetical protein Francci3_2319 1 None None None 86740576 Nonpathogen - hypothetical protein Francci3_1871 2 None None None 86741999 Common - transposase, IS4 Francci3_3313 28 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86740622 Common - regulatory protein GntR, HTH Francci3_1917 83 COG2186 FadR, Transcriptional regulators Transcription 86741864 Common - PAS/PAC sensor signal transduction histidine kinase Francci3_3178 221 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 86741045 Nonpathogen - hypothetical protein Francci3_2349 1 None None None 86740225 Common cobH precorrin-8X methylmutase Francci3_1520 118 COG2082 CobH, Precorrin isomerase Coenzyme metabolism 86742659 Common - transcriptional regulator, TetR family Francci3_3980 27 COG1309 AcrR, Transcriptional regulator Transcription 86739809 Common - NUDIX hydrolase Francci3_1099 77 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 86741055 Nonpathogen - hypothetical protein Francci3_2359 1 None None None 86740320 Nonpathogen - hypothetical protein Francci3_1615 4 COG0716 FldA, Flavodoxins Energy production and conversion 86743002 Common - hypothetical protein Francci3_4327 17 None None None 86742953 Common - transcription factor WhiB Francci3_4278 19 None None None 86741406 Nonpathogen - hypothetical protein Francci3_2716 1 None None None 86742379 Nonpathogen - anti-sigma-factor antagonist (STAS) domain protein Francci3_3698 1 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 86738755 Common - nitrogen regulatory protein P-II Francci3_0032 170 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 86740643 Common - hypothetical protein Francci3_1939 7 None None None 86739842 Common - metal dependent phosphohydrolase Francci3_1134 7 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 86740801 Nonpathogen - hypothetical protein Francci3_2100 1 None None None 86739995 Common - oxidoreductase-like Francci3_1289 22 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 86742305 Common - periplasmic sensor signal transduction histidine kinase Francci3_3624 218 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 86742700 Nonpathogen - hypothetical protein Francci3_4021 1 None None None 86743106 Common - FHA domain containing protein Francci3_4431 44 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 86740216 Common - hypothetical protein Francci3_1511 6 None None None 86741294 Common - cobyric acid synthase Francci3_2603 150 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 86743209 Common - serine/threonine protein kinase Francci3_4534 46 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86739633 Nonpathogen - hypothetical protein Francci3_0920 2 None None None 86740308 Common - Thioesterase Francci3_1603 49 COG3208 GrsT, Predicted thioesterase involved in non-ribosomal peptide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 86739405 Common - aspartyl-tRNA synthetase Francci3_0692 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86741721 Common - protein of unknown function DUF125, transmembrane Francci3_3035 72 COG1814 COG1814, Uncharacterized membrane protein Function unknown 86743082 Common - dihydropteroate synthase Francci3_4407 208 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 86739412 Nonpathogen - hypothetical protein Francci3_0699 1 None None None 86739910 Common - phage integrase Francci3_1203 84 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86740171 Common - protein of unknown function DUF1290 Francci3_1465 10 COG3856 Sbp, Uncharacterized conserved protein (small basic protein) Function unknown 86740366 Common - FeS assembly protein SufD Francci3_1661 173 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 86738826 Common - putative isomerase Francci3_0103 14 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 86739512 Common - protein of unknown function DUF214 Francci3_0799 64 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 86740265 Common - putative signal transduction histidine kinase Francci3_1560 62 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 86739313 Common - ribosomal protein L30 Francci3_0600 135 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 86738936 Common - putative serine/threonine kinase anti-sigma factor Francci3_0218 7 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 86739253 Common - NADH dehydrogenase subunit C Francci3_0540 172 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 86742914 Common - periplasmic binding protein Francci3_4239 82 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 86741291 Common - ribose-phosphate pyrophosphokinase Francci3_2600 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 86742112 Nonpathogen - putative integral membrane protein Francci3_3429 1 None None None 86742273 Common - 16S rRNA processing protein RimM Francci3_3592 164 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 86742843 Common - Integrase Francci3_4166 45 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741035 Common - hypothetical protein Francci3_2338 10 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 86739791 Nonpathogen - hypothetical protein Francci3_1080 3 None None None 86743063 Common - hypothetical protein Francci3_4388 13 None None None 86738924 Nonpathogen - hypothetical protein Francci3_0205 6 None None None 86739136 Common - PII uridylyl-transferase Francci3_0420 123 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 86741481 Common - copper resistance protein CopC Francci3_2794 12 COG2372 CopC, Uncharacterized protein, homolog of Cu resistance protein CopC General function prediction only 86738737 Common - Peptide deformylase Francci3_0014 210 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 86740419 Nonpathogen - hypothetical protein Francci3_1714 1 None None None 86742903 Common - Hemerythrin HHE cation binding region Francci3_4228 18 None None None 86739358 Common guaA bifunctional GMP synthase/glutamine amidotransferase protein Francci3_0645 240 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 86743129 Common - S-adenosyl-L-homocysteine hydrolase Francci3_4454 177 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 86741361 Common - ABC transporter related Francci3_2670 230 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 86741239 Nonpathogen - transposase Francci3_2546 3 None None None 86742932 Nonpathogen - hypothetical protein Francci3_4257 3 COG2847 COG2847, Uncharacterized protein conserved in bacteria Function unknown 86739431 Nonpathogen - hypothetical protein Francci3_0718 1 None None None 86739799 Common - transposase, IS4 Francci3_1089 30 COG5659 COG5659, FOG: Transposase DNA replication, recombination, and repair 86741473 Common - pyruvate dehydrogenase Francci3_2785 154 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 86739164 Common - Rhodanese-like Francci3_0449 144 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 86740450 Common - protein of unknown function DUF574 Francci3_1745 6 None None None 86740743 Common - alkylhydroperoxidase Francci3_2040 73 COG2128 COG2128, Uncharacterized conserved protein Function unknown 86741371 Common - Transposase and inactivated derivatives-like Francci3_2680 49 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740858 Common - metal-dependent hydrolase Francci3_2157 69 COG3454 COG3454, Metal-dependent hydrolase involved in phosphonate metabolism Inorganic ion transport and metabolism 86741072 Common - hypothetical protein Francci3_2376 6 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 86738800 Nonpathogen - hypothetical protein Francci3_0077 1 None None None 86740033 Common - hypothetical protein Francci3_1327 3 COG0392 COG0392, Predicted integral membrane protein Function unknown 86741817 Common - cobalamin 5'-phosphate synthase Francci3_3131 12 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 86742116 Common - NUDIX hydrolase Francci3_3433 10 COG3793 TerB, Tellurite resistance protein Inorganic ion transport and metabolism 86739711 Common - Crotonyl-CoA reductase Francci3_0999 179 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 86739222 Common - Methyltransferase type 12 Francci3_0509 53 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86741662 Common - Allergen V5/Tpx-1 related Francci3_2976 31 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 86742566 Common - Adenylate kinase Francci3_3887 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 86740882 Common - transposase, IS4 Francci3_2183 18 None None None 86738937 Common - hypothetical protein Francci3_0219 6 None None None 86739217 Common - transcriptional regulator, MerR family Francci3_0503 42 COG0789 SoxR, Predicted transcriptional regulators Transcription 86739973 Common - protein of unknown function DUF558 Francci3_1266 16 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 86738841 Common - putative IS630 family transposase Francci3_0118 15 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739082 Common - hypothetical protein Francci3_0366 2 None None None 86741160 Common - chorismate mutase Francci3_2464 38 COG4401 AroH, Chorismate mutase Amino acid transport and metabolism 86742336 Nonpathogen - hypothetical protein Francci3_3655 1 None None None 86739557 Nonpathogen - hypothetical protein Francci3_0844 1 None None None 86742100 Nonpathogen - hypothetical protein Francci3_3417 1 None None None 86740602 Common - short-chain dehydrogenase/reductase SDR Francci3_1897 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 86741413 Nonpathogen - hypothetical protein Francci3_2724 1 None None None 86741195 Common - electron transport protein SCO1/SenC Francci3_2499 94 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 86739441 Nonpathogen - hypothetical protein Francci3_0728 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 86741456 Common - extracellular solute-binding protein, family 5 Francci3_2767 198 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 86741848 Common - hypothetical protein Francci3_3162 5 COG2015 COG2015, Alkyl sulfatase and related hydrolases Secondary metabolites biosynthesis, transport, and catabolism 86743029 Common - chaperone DnaJ-like Francci3_4354 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 86739059 Common - inner-membrane translocator Francci3_0343 137 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 86742650 Nonpathogen - hypothetical protein Francci3_3971 1 None None None 86740947 Common - transcriptional regulator, LysR family Francci3_2250 175 COG0583 LysR, Transcriptional regulator Transcription 86741240 Common - NUDIX hydrolase Francci3_2547 52 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 86739784 Common - NHL repeat protein Francci3_1073 15 None None None 86741177 Common - transposase, IS4 Francci3_2481 28 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86741323 Common - tRNA (adenine-N(1)-)-methyltransferase Francci3_2632 61 COG2519 GCD14, tRNA(1-methyladenosine) methyltransferase and related methyltransferases Translation, ribosomal structure and biogenesis 86741096 Common - periplasmic sensor signal transduction histidine kinase Francci3_2400 165 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 86739448 Common - glycosyl transferase, group 1 Francci3_0735 154 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86739567 Common - ABC transporter related Francci3_0854 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 86738887 Common - hypothetical protein Francci3_0166 15 None None None 86739591 Common - phage integrase Francci3_0878 63 COG0582 XerC, Integrase DNA replication, recombination, and repair 86740475 Common - adenosine deaminase Francci3_1770 100 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 86739345 Common groES co-chaperonin GroES Francci3_0632 216 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 86742226 Common - acetate kinase Francci3_3545 161 COG0282 ackA, Acetate kinase Energy production and conversion 86741061 Common - hypothetical protein Francci3_2365 3 None None None 86741992 Nonpathogen - hypothetical protein Francci3_3306 1 None None None 86738805 Common - phosphoserine aminotransferase Francci3_0082 194 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 86739062 Common - FAD-linked oxidoreductase Francci3_0346 46 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 86742425 Common - superfamily I DNA and RNA helicases and helicase subunits-like Francci3_3745 67 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 86739581 Common - cysteine synthases Francci3_0868 220 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 86740950 Common - binding-protein-dependent transport systems inner membrane component Francci3_2253 142 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 86741070 Nonpathogen - hypothetical protein Francci3_2374 1 None None None 86740288 Nonpathogen - hypothetical protein Francci3_1583 4 None None None 86740001 Nonpathogen - Methyltransferase FkbM Francci3_1295 1 None None None 86740097 Common - CDP-alcohol phosphatidyltransferase Francci3_1391 33 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 86740982 Nonpathogen - hypothetical protein Francci3_2285 1 None None None 86741394 Common - transposase, IS4 Francci3_2704 28 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86740612 Common - glycosyl transferase, group 1 Francci3_1907 156 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86742179 Common - Xaa-Pro aminopeptidase Francci3_3497 204 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 86740864 Common - AMP-dependent synthetase and ligase Francci3_2165 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86741063 Common - transposase Tn3 Francci3_2367 52 COG4644 COG4644, Transposase and inactivated derivatives, TnpA family DNA replication, recombination, and repair 86742894 Common - transposase, IS4 Francci3_4218 28 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86743098 Common - Rhodanese-like Francci3_4423 63 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 86739800 Nonpathogen - hypothetical protein Francci3_1090 1 None None None 86742549 Nonpathogen - hypothetical protein Francci3_3870 1 None None None 86742207 Common recA recombinase A Francci3_3525 214 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 86739752 Nonpathogen - hypothetical protein Francci3_1041 1 None None None 86739858 Common - alpha amylase, catalytic region Francci3_1150 149 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 86740667 Common - Phenazine biosynthesis PhzC/PhzF protein Francci3_1963 120 COG0384 COG0384, Predicted epimerase, PhzC/PhzF homolog General function prediction only 86740027 Common - hypothetical protein Francci3_1321 15 None None None 86740345 Common secG preprotein translocase subunit SecG Francci3_1640 14 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 86742575 Common - PhoH-like protein Francci3_3896 199 COG1875 COG1875, Predicted ATPase related to phosphate starvation-inducible protein PhoH Signal transduction mechanisms 86742799 Common - transposase IS116/IS110/IS902 Francci3_4122 79 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741865 Common - tRNA/rRNA methyltransferase Francci3_3179 193 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 86742723 Nonpathogen - hypothetical protein Francci3_4044 1 None None None 86741418 Common - helicase-like Francci3_2729 152 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 86739550 Common - (2Fe-2S)-binding Francci3_0837 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 86743214 Common - hypothetical protein Francci3_4539 11 None None None 86739140 Common - iron dependent repressor Francci3_0424 72 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 86743188 Common - hypothetical protein Francci3_4513 37 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 86740201 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding Francci3_1496 6 None None None 86740681 Common - beta-ketoacyl synthase Francci3_1978 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 86740552 Nonpathogen - hypothetical protein Francci3_1847 1 None None None 86739619 Nonpathogen - Type IV secretory pathway VirD4 components-like Francci3_0906 15 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 86741508 Nonpathogen - hypothetical protein Francci3_2821 1 None None None 86742127 Nonpathogen - hypothetical protein Francci3_3444 1 None None None 86742145 Common - Amidohydrolase 3 Francci3_3462 31 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 86739463 Common - hypothetical protein Francci3_0750 17 None None None 86740549 Common - putative protein Ymh Francci3_1844 10 None None None 86739935 Common - malate synthase Francci3_1228 74 COG2225 AceB, Malate synthase Energy production and conversion 86743078 Nonpathogen - hypothetical protein Francci3_4403 1 None None None 86741808 Common - quinolinate synthetase Francci3_3122 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 86741448 Common - Alpha/beta hydrolase fold-3 Francci3_2759 80 COG0657 Aes, Esterase/lipase Lipid metabolism 86740090 Common - von Willebrand factor, type A Francci3_1384 76 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 86742984 Common - two component transcriptional regulator, winged helix family Francci3_4309 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86739234 Nonpathogen - hypothetical protein Francci3_0521 1 None None None 86740260 Common - transcriptional regulator, MerR family Francci3_1555 118 COG0789 SoxR, Predicted transcriptional regulators Transcription 86742124 Common - malate dehydrogenase Francci3_3441 123 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 86740204 Nonpathogen - hypothetical protein Francci3_1499 1 None None None 86741174 Common - ABC transporter related Francci3_2478 197 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 86739574 Common - NUDIX hydrolase Francci3_0861 107 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 86741859 Common - acetylglutamate kinase Francci3_3173 219 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 86741305 Common - Carboxymethylenebutenolidase Francci3_2614 66 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 86742998 Nonpathogen - hypothetical protein Francci3_4323 1 None None None 86741741 Common - hypothetical protein Francci3_3055 16 None None None 86739305 Common rplN 50S ribosomal protein L14 Francci3_0592 247 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 86743057 Nonpathogen - hypothetical protein Francci3_4382 1 None None None 86739474 Common - putative integral membrane protein Francci3_0761 7 None None None 86740654 Common - transposase, IS4 Francci3_1950 28 None None None 86741085 Nonpathogen - putative integral membrane protein Francci3_2389 3 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 86739675 Common - D-lactate dehydrogenase (cytochrome) Francci3_0962 201 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 86742320 Common ilvH acetolactate synthase 3 regulatory subunit Francci3_3639 193 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 86738878 Nonpathogen - hypothetical protein Francci3_0156 5 None None None 86739606 Nonpathogen - hypothetical protein Francci3_0893 1 None None None 86741461 Common - transcriptional regulator, XRE family Francci3_2772 16 COG1396 HipB, Predicted transcriptional regulators Transcription 86738793 Common - large conductance mechanosensitive channel protein Francci3_0070 143 COG1970 MscL, Large-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 86739641 Common - hypothetical protein Francci3_0928 4 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 86740932 Nonpathogen - hypothetical protein Francci3_2235 2 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 86740383 Common - Pyruvate kinase Francci3_1678 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 86742897 Common - putative maturase Francci3_4221 4 None None None 86739369 Common - phosphoribosylglycinamide formyltransferase Francci3_0656 226 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 86740377 Common - putative integral membrane protein Francci3_1672 6 None None None 86740893 Nonpathogen - hypothetical protein Francci3_2195 1 None None None 86738975 Common - Abortive infection protein Francci3_0258 16 None None None 86739193 Common - protein of unknown function DUF62 Francci3_0478 68 COG1912 COG1912, Uncharacterized conserved protein Function unknown 86740812 Common - monooxygenase, FAD-binding Francci3_2111 81 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 86740598 Common - sodium/hydrogen exchanger Francci3_1893 164 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 86740889 Common - proline iminopeptidase Francci3_2191 102 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86740927 Common - heat shock protein HtpX Francci3_2230 189 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 86741318 Common - 20S proteasome, A and B subunits Francci3_2627 50 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 86743172 Common - NADH ubiquinone oxidoreductase, 20 kDa subunit Francci3_4497 47 COG1941 FrhG, Coenzyme F420-reducing hydrogenase, gamma subunit Energy production and conversion 86739736 Nonpathogen - hypothetical protein Francci3_1024 1 None None None 86741957 Nonpathogen - hypothetical protein Francci3_3271 2 None None None 86740638 Common - beta-ketoacyl synthase Francci3_1934 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86740184 Common - Alpha,alpha-trehalose-phosphate synthase (UDP-forming) Francci3_1478 95 COG0380 OtsA, Trehalose-6-phosphate synthase Carbohydrate transport and metabolism 86741312 Common - ABC transporter related Francci3_2621 242 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 86743198 Nonpathogen - hypothetical protein Francci3_4523 1 None None None 86742268 Common - hypothetical protein Francci3_3587 17 None None None 86740123 Common - UDP-N-acetylmuramate--alanine ligase Francci3_1417 207 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 86741984 Nonpathogen - hypothetical protein Francci3_3298 1 None None None 86742218 Common - transcriptional regulator, XRE family Francci3_3537 17 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 86739204 Common - Heavy metal transport/detoxification protein Francci3_0489 21 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 86738783 Common - poly-gamma-glutamate biosynthesis protein Francci3_0060 58 COG2843 PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) Cell envelope biogenesis, outer membrane 86742728 Common - GAF sensor hybrid histidine kinase Francci3_4049 221 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 86740259 Common - major facilitator superfamily MFS_1 Francci3_1554 178 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 86742769 Common - S-adenosyl-L-homocysteine hydrolase Francci3_4092 176 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 86742803 Common - putative replication initiation protein Francci3_4126 5 None None None 86741777 Common - LOR/SDH bifunctional enzyme conserved region Francci3_3091 33 COG1915 COG1915, Uncharacterized conserved protein Function unknown 86742678 Nonpathogen - hypothetical protein Francci3_3999 2 None None None 86742710 Common - PilT protein-like Francci3_4031 4 COG2402 COG2402, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 86739329 Common - phosphoglucosamine mutase Francci3_0616 238 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 86742520 Common - conserved hypothetical protein 730 Francci3_3841 128 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 86741655 Common - Cupin 2 Francci3_2969 29 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 86742978 Common - putative serine/threonine kinase anti-sigma factor Francci3_4303 7 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 86741172 Common - ABC-3 Francci3_2476 38 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 86740006 Common - Heparinase II/III-like Francci3_1300 35 COG5360 COG5360, Uncharacterized protein conserved in bacteria Function unknown 86742406 Common - homoserine dehydrogenase Francci3_3725 175 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 86742604 Common - transcriptional regulator, MerR family Francci3_3925 149 COG0789 SoxR, Predicted transcriptional regulators Transcription 86742824 Common - phosphopantetheine-binding Francci3_4147 4 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86739325 Common truA tRNA pseudouridine synthase A Francci3_0612 233 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 86739219 Nonpathogen - hypothetical protein Francci3_0506 1 None None None 86741979 Common - putative transcriptional regulator Francci3_3293 146 COG1733 COG1733, Predicted transcriptional regulators Transcription 86743095 Nonpathogen - hypothetical protein Francci3_4420 1 None None None 86739023 Common - fatty acid desaturase, type 2 Francci3_0307 11 None None None 86741916 Common - protein of unknown function DUF470 Francci3_3230 28 COG2898 COG2898, Uncharacterized conserved protein Function unknown 86741092 Common - hypothetical protein Francci3_2396 42 COG3651 COG3651, Uncharacterized protein conserved in bacteria Function unknown 86738972 Common - transcriptional repressor, CopY family Francci3_0255 24 COG3682 COG3682, Predicted transcriptional regulator Transcription 86739118 Common - transposase, IS4 Francci3_0402 30 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741598 Common - Enzymatic protein of unknown function Francci3_2911 112 COG2308 COG2308, Uncharacterized conserved protein Function unknown 86739179 Common - extracellular solute-binding protein, family 1 Francci3_0464 24 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 86739212 Nonpathogen - hypothetical protein Francci3_0498 5 None None None 86742410 Common - hypothetical protein Francci3_3729 82 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 86741229 Common - putative serine/threonine kinase anti-sigma factor Francci3_2536 4 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 86741002 Common - twin-arginine translocation protein, TatA/E family Francci3_2305 7 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 86741815 Common - cobalbumin biosynthesis enzyme Francci3_3129 123 COG2087 CobU, Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase Coenzyme metabolism 86740965 Common - Protein-methionine-S-oxide reductase Francci3_2268 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 86741940 Common - putative transcriptional regulator Francci3_3254 9 None None None 86741026 Common - hypothetical protein Francci3_2329 18 None None None 86742428 Common kgd alpha-ketoglutarate decarboxylase Francci3_3748 194 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 86739167 Common - hypothetical protein Francci3_0452 16 None None None 86739006 Common - response regulator receiver modulated serine phosphatase Francci3_0290 128 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 86739518 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Francci3_0805 51 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 86741607 Common - hypothetical protein Francci3_2920 7 None None None 86743158 Common - Dinitrogenase iron-molybdenum cofactor biosynthesis Francci3_4483 32 None None None 86740524 Common - Protein-L-isoaspartate(D-aspartate) O-methyltransferase Francci3_1819 155 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 86742089 Common - AAA ATPase, central region Francci3_3406 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 86740597 Common - TrkA-like Francci3_1892 32 COG0490 COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels Inorganic ion transport and metabolism 86740723 Common - daunorubicin resistance ABC transporter ATP-binding subunit Francci3_2020 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 86741697 Common - adenylate kinase Francci3_3011 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 86743207 Common - hypothetical protein Francci3_4532 11 None None None 86742245 Common - NusA antitermination factor Francci3_3564 220 COG0195 NusA, Transcription elongation factor Transcription 86742529 Nonpathogen - hypothetical protein Francci3_3850 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 86740520 Common - transcriptional coactivator/pterin dehydratase Francci3_1815 33 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 86739417 Nonpathogen - hypothetical protein Francci3_0704 1 COG5373 COG5373, Predicted membrane protein Function unknown 86742837 Nonpathogen - hypothetical protein Francci3_4160 1 None None None 86743138 Nonpathogen - hypothetical protein Francci3_4463 1 None None None 86739489 Common - hypothetical protein Francci3_0776 6 None None None 86742965 Common - NUDIX hydrolase Francci3_4290 114 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 86740426 Common - hypothetical protein Francci3_1721 19 None None None 86743223 Common rpmH 50S ribosomal protein L34 Francci3_4548 196 None None None 86739928 Common rpmA 50S ribosomal protein L27 Francci3_1221 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 86741505 Common - bacterioferritin Francci3_2818 106 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 86739555 Common - Transthyretin Francci3_0842 63 COG2351 COG2351, Transthyretin-like protein General function prediction only 86739689 Common - NAD-dependent epimerase/dehydratase Francci3_0976 230 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 86739384 Nonpathogen - hypothetical protein Francci3_0671 1 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 86739893 Common - dihydroorotate dehydrogenase Francci3_1185 88 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 86741145 Common - alpha/beta hydrolase fold Francci3_2449 144 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86741933 Common - hypothetical protein Francci3_3247 15 COG5634 COG5634, Uncharacterized conserved protein Function unknown 86742981 Common - Thymidylate kinase Francci3_4306 227 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 86742018 Common - type II secretion system protein E Francci3_3332 138 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 86741950 Common - hypothetical protein Francci3_3264 3 None None None 86740600 Common - Pyruvate dehydrogenase complex dehydrogenase (E1) component-like Francci3_1895 93 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 86739184 Common - phosphate uptake regulator, PhoU Francci3_0469 193 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 86740830 Nonpathogen - hypothetical protein Francci3_2129 2 None None None 86742717 Common moaC molybdenum cofactor biosynthesis protein C Francci3_4038 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 86741276 Common - ApbE-like lipoprotein Francci3_2585 110 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 86739423 Common - hypothetical protein Francci3_0710 14 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86739856 Common - putative ABC transporter ATP-binding protein Francci3_1148 244 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 86738748 Common - hypothetical protein Francci3_0025 2 None None None 86739084 Common - diguanylate cyclase (GGDEF domain) with PAS/PAC sensor Francci3_0368 182 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 86739542 Common - glycosyl transferase, family 2 Francci3_0829 74 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86741784 Common - glycosyl transferase, group 1 Francci3_3098 214 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86740113 Common - methyltransferase Francci3_1407 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 86742446 Nonpathogen - hypothetical protein Francci3_3766 3 None None None 86740193 Nonpathogen - hypothetical protein Francci3_1488 1 None None None 86742947 Common - cell divisionFtsK/SpoIIIE Francci3_4272 73 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 86743055 Common - putative secreted hydrolase Francci3_4380 15 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 86739349 Common - inosine-5'-monophosphate dehydrogenase Francci3_0636 240 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 86740154 Common - beta-lactamase-like Francci3_1448 209 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 86742413 Common - hypothetical protein Francci3_3733 6 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 86738835 Common metH B12-dependent methionine synthase Francci3_0112 175 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 86742694 Common - UBA/THIF-type NAD/FAD binding fold Francci3_4015 201 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 86740652 Common - Hydrogenase expression/formation protein HypE Francci3_1948 119 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 86739067 Common - short-chain dehydrogenase/reductase SDR Francci3_0351 234 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 86742731 Nonpathogen - hypothetical protein Francci3_4052 1 None None None 86741875 Common - putative RNA-binding Sun protein Francci3_3189 113 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 86738889 Common - NAD-dependent epimerase/dehydratase Francci3_0168 80 COG2910 COG2910, Putative NADH-flavin reductase General function prediction only 86739482 Common - hypothetical protein Francci3_0769 6 None None None 86740467 Common - Rubrerythrin Francci3_1762 37 COG1592 COG1592, Rubrerythrin Energy production and conversion 86739635 Common - hypothetical protein Francci3_0922 19 None None None 86742293 Common - Phosphomethylpyrimidine kinase Francci3_3612 213 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 86742993 Common - Cof protein Francci3_4318 89 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 86740133 Nonpathogen - hypothetical protein Francci3_1427 1 None None None 86742884 Common - Salicylate 1-monooxygenase Francci3_4207 72 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 86739777 Nonpathogen - Hemerythrin HHE cation binding region Francci3_1066 5 None None None 86739104 Common - hypothetical protein Francci3_0388 35 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86739060 Common - ABC transporter related Francci3_0344 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 86740530 Nonpathogen - hypothetical protein Francci3_1825 8 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 86741611 Common - MaoC-like dehydratase Francci3_2924 81 COG2030 MaoC, Acyl dehydratase Lipid metabolism 86739593 Common - antirestriction protein Francci3_0880 14 COG4734 ArdA, Antirestriction protein General function prediction only 86740079 Common secD preprotein translocase subunit SecD Francci3_1373 210 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 86740010 Common - glycosyl transferase, group 1 Francci3_1304 108 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86739501 Nonpathogen - hypothetical protein Francci3_0788 1 None None None 86742634 Nonpathogen - hypothetical protein Francci3_3955 1 None None None 86742810 Common - flavin reductase-like, FMN-binding Francci3_4133 92 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 86739034 Common - glycosyl transferase, family 2 Francci3_0318 116 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86742790 Common - putative IS630 family transposase Francci3_4113 15 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741532 Common - DNA helicase, putative Francci3_2845 80 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 86739855 Common - protein of unknown function DUF1254 Francci3_1147 38 COG5361 COG5361, Uncharacterized conserved protein Function unknown 86742055 Common - FAD dependent oxidoreductase Francci3_3371 40 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 86741399 Nonpathogen - hypothetical protein Francci3_2709 1 COG1708 COG1708, Predicted nucleotidyltransferases General function prediction only 86738896 Common - amidase Francci3_0175 219 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 86741352 Common - ferric uptake regulator, FUR family Francci3_2661 38 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 86739547 Common ureA urease subunit gamma Francci3_0834 96 COG0831 UreA, Urea amidohydrolase (urease) gamma subunit Amino acid transport and metabolism 86740396 Nonpathogen - hypothetical protein Francci3_1691 2 COG5373 COG5373, Predicted membrane protein Function unknown 86742785 Common - Prevent-host-death protein Francci3_4108 3 COG4118 Phd, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 86742813 Nonpathogen - hypothetical protein Francci3_4136 1 None None None 86740072 Common - pyridoxine biosynthesis protein Francci3_1366 87 COG0214 SNZ1, Pyridoxine biosynthesis enzyme Coenzyme metabolism 86741338 Common - membrane protein-like Francci3_2647 17 COG5305 COG5305, Predicted membrane protein Function unknown 86740124 Common - cell division protein FtsZ Francci3_1418 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 86739944 Common - putative transposase Francci3_1237 12 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739050 Common - hypothetical protein Francci3_0334 5 None None None 86739332 Common - transcriptional regulator, PadR-like family Francci3_0619 57 COG1695 COG1695, Predicted transcriptional regulators Transcription 86742522 Common - glycoside hydrolase, family 16 Francci3_3843 48 COG2273 SKN1, Beta-glucanase/Beta-glucan synthetase Carbohydrate transport and metabolism 86738854 Common - NUDIX hydrolase Francci3_0131 168 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 86739698 Common - transcriptional regulator, ArsR family Francci3_0985 63 COG0640 ArsR, Predicted transcriptional regulators Transcription 86738962 Common - hypothetical protein Francci3_0245 31 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 86739304 Common - ribosomal protein S17 Francci3_0591 224 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 86738893 Common - hypothetical protein Francci3_0172 7 None None None 86740682 Nonpathogen - response regulator receiver protein Francci3_1979 1 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86739705 Common - FAD dependent oxidoreductase Francci3_0993 13 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 86741577 Nonpathogen - hypothetical protein Francci3_2890 1 None None None 86739333 Common acpS 4'-phosphopantetheinyl transferase Francci3_0620 16 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 86740505 Common - Endonuclease/exonuclease/phosphatase Francci3_1800 4 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 86742665 Common - ABC transporter related Francci3_3986 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 86740380 Common - Enoyl-CoA hydratase/isomerase Francci3_1675 126 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 86741782 Nonpathogen - metallophosphoesterase Francci3_3096 3 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 86742443 Common - biotin synthase Francci3_3763 180 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 86740995 Common - cob(I)yrinic acid a,c-diamide adenosyltransferase Francci3_2298 141 COG2109 BtuR, ATP:corrinoid adenosyltransferase Coenzyme metabolism 86741268 Nonpathogen - hypothetical protein Francci3_2577 1 None None None 86741137 Nonpathogen - hypothetical protein Francci3_2441 1 None None None 86739734 Common - transcriptional regulator, XRE family Francci3_1022 6 COG5606 COG5606, Uncharacterized conserved small protein Function unknown 86743016 Common - ABC transporter related Francci3_4341 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 86743144 Common - cold-shock DNA-binding domain protein Francci3_4469 181 COG1278 CspC, Cold shock proteins Transcription 86740708 Common - putative transcriptional regulator Francci3_2005 144 COG1733 COG1733, Predicted transcriptional regulators Transcription 86739673 Nonpathogen - hypothetical protein Francci3_0960 3 None None None 86739147 Common - 3-amino-5-hydroxybenoic acid synthesis related Francci3_0431 194 COG0546 Gph, Predicted phosphatases General function prediction only 86741632 Common - Alcohol dehydrogenase, zinc-binding Francci3_2945 210 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 86740317 Common - NLP/P60 Francci3_1612 12 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 86742033 Common - protein of unknown function DUF196 Francci3_3347 36 COG1343 COG1343, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 86742064 Common - hypothetical protein Francci3_3380 134 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 86740500 Common - protein of unknown function DUF574 Francci3_1795 12 None None None 86740106 Nonpathogen - hypothetical protein Francci3_1400 1 None None None 86739906 Nonpathogen - putative ATP-binding protein Francci3_1199 11 None None None 86740803 Common - putative asparagine synthetase Francci3_2102 3 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 86739504 Common - peptide chain release factor 2 Francci3_0791 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 86741589 Common - protein of unknown function DUF124 Francci3_2902 22 COG2013 COG2013, Uncharacterized conserved protein Function unknown 86742598 Common - Uracil-DNA glycosylase superfamily Francci3_3919 74 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 86741948 Nonpathogen - hypothetical protein Francci3_3262 1 None None None 86738791 Nonpathogen - sigma-24 Francci3_0068 1 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 86739536 Common - Squalene cyclase Francci3_0823 45 COG1657 SqhC, Squalene cyclase Lipid metabolism 86739366 Nonpathogen - putative antigen 34 kDa family Francci3_0653 1 None None None 86741887 Common pyrC dihydroorotase Francci3_3201 213 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 86741381 Common - hypothetical protein Francci3_2691 21 COG0392 COG0392, Predicted integral membrane protein Function unknown 86739498 Nonpathogen - aminoglycoside phosphotransferase Francci3_0785 7 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 86741435 Nonpathogen - ribonuclease BN Francci3_2746 3 COG1295 Rbn, Predicted membrane protein Function unknown 86742303 Common - transcriptional regulator, IclR family Francci3_3622 87 COG1414 IclR, Transcriptional regulator Transcription 86740082 Common - (p)ppGpp synthetase I Francci3_1376 205 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 86740580 Common - Transposase and inactivated derivatives-like Francci3_1875 11 COG3666 COG3666, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740234 Nonpathogen - hypothetical protein Francci3_1529 1 None None None 86739968 Common - ribosomal protein S20 Francci3_1261 192 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 86739133 Nonpathogen - hypothetical protein Francci3_0417 1 None None None 86740525 Nonpathogen - hypothetical protein Francci3_1820 2 None None None 86741348 Common - precorrin 6A synthase Francci3_2657 47 COG2243 CobF, Precorrin-2 methylase Coenzyme metabolism 86741205 Common - Hydantoinase/oxoprolinase Francci3_2509 99 COG0145 HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86739849 Nonpathogen - hypothetical protein Francci3_1141 1 None None None 86739290 Common rpsL 30S ribosomal protein S12 Francci3_0577 246 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 86741904 Common - regulatory protein GntR, HTH Francci3_3218 81 COG2186 FadR, Transcriptional regulators Transcription 86742282 Common rnc ribonuclease III Francci3_3601 215 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 86742587 Common - hypothetical protein Francci3_3908 18 COG3591 COG3591, V8-like Glu-specific endopeptidase Amino acid transport and metabolism 86741843 Common - CTP synthetase Francci3_3157 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 86739840 Common - restriction endonuclease Francci3_1132 36 COG1715 Mrr, Restriction endonuclease Defense mechanisms 86741837 Common - NADPH-dependent F420 reductase Francci3_3151 60 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 86742645 Nonpathogen - hypothetical protein Francci3_3966 5 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 86742107 Common - aminoglycoside phosphotransferase Francci3_3424 19 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 86741550 Common - protein of unknown function DUF445 Francci3_2863 49 COG2733 COG2733, Predicted membrane protein Function unknown 86741037 Common - protein of unknown function DUF1234 Francci3_2340 51 COG3545 COG3545, Predicted esterase of the alpha/beta hydrolase fold General function prediction only 86738798 Common - phage SPO1 DNA polymerase-related protein Francci3_0075 147 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 86739835 Nonpathogen - Lanthionine synthetase C-like Francci3_1126 6 None None None 86742042 Nonpathogen - hypothetical protein Francci3_3358 1 None None None 86739453 Common - hypothetical protein Francci3_0740 7 None None None 86738984 Nonpathogen - hypothetical protein Francci3_0267 1 None None None 86739837 Common - Protein-L-isoaspartate(D-aspartate) O-methyltransferase Francci3_1128 155 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 86739248 Common ubiE ubiquinone/menaquinone biosynthesis methyltransferase Francci3_0535 207 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86742570 Nonpathogen - hypothetical protein Francci3_3891 1 None None None 86740845 Nonpathogen - hypothetical protein Francci3_2144 1 None None None 86738998 Common - Mur ligase Francci3_0282 46 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 86739476 Common - amidophosphoribosyltransferases-like Francci3_0763 12 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 86740558 Common - putative TmrB-like protein Francci3_1853 12 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 86740477 Common - major facilitator superfamily MFS_1 Francci3_1772 95 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86741050 Nonpathogen - hypothetical protein Francci3_2354 1 None None None 86742091 Common - threonyl-tRNA synthetase Francci3_3408 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86739940 Common - Iojap-related protein Francci3_1233 29 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 86740733 Nonpathogen - hypothetical protein Francci3_2030 3 None None None 86742878 Common - ABC transporter related Francci3_4201 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 86742693 Common - N-6 DNA methylase Francci3_4014 159 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 86739209 Nonpathogen - hypothetical protein Francci3_0495 1 None None None 86740022 Common - hypothetical protein Francci3_1316 186 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 86741220 Common - HhH-GPD Francci3_2526 11 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 86741897 Common - Shikimate 5-dehydrogenase Francci3_3211 185 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 86741595 Common - GCN5-related N-acetyltransferase Francci3_2908 31 None None None 86740364 Common - putative transcriptional regulator Francci3_1659 33 COG2345 COG2345, Predicted transcriptional regulator Transcription 86741606 Common - toxic anion resistance Francci3_2919 26 COG3853 TelA, Uncharacterized protein involved in tellurite resistance Inorganic ion transport and metabolism 86740340 Common - hypothetical protein Francci3_1635 88 COG0391 COG0391, Uncharacterized conserved protein Function unknown 86741043 Common - transposase Tn3 Francci3_2347 51 COG4644 COG4644, Transposase and inactivated derivatives, TnpA family DNA replication, recombination, and repair 86740781 Common - transposase, IS4 Francci3_2080 56 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741255 Common - PilT protein-like Francci3_2564 3 None None None 86739270 Common - heat shock protein HtpX Francci3_0557 191 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 86741112 Common - ABC transporter related Francci3_2416 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 86741966 Nonpathogen - Transglutaminase-like Francci3_3280 1 None None None 86743135 Common - polyhydroxybutyrate depolymerase Francci3_4460 42 COG3509 LpqC, Poly(3-hydroxybutyrate) depolymerase Secondary metabolites biosynthesis, transport, and catabolism 86739072 Nonpathogen - hypothetical protein Francci3_0356 1 None None None 86742392 Common - ATP synthase F0, B subunit Francci3_3711 17 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 86741896 Common - peptidase A24A, prepilin type IV Francci3_3210 10 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 86742927 Common - pyridoxamine 5'-phosphate oxidase-related, FMN-binding Francci3_4252 10 COG3871 COG3871, Uncharacterized stress protein (general stress protein 26) General function prediction only 86738909 Nonpathogen - hypothetical protein Francci3_0189 1 None None None 86742256 Common - 1-deoxy-D-xylulose 5-phosphate reductoisomerase Francci3_3575 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 86742832 Common - transposase, IS4 Francci3_4155 28 None None None 86738864 Common - PilT protein-like Francci3_0141 7 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 86742340 Common - electron transfer flavoprotein beta-subunit Francci3_3659 153 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 86743047 Common - adenylosuccinate lyase Francci3_4372 235 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 86739609 Common - hypothetical protein Francci3_0896 3 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 86741679 Common - S-adenosylmethionine synthetase Francci3_2993 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 86741570 Nonpathogen - hypothetical protein Francci3_2883 2 None None None 86740712 Common - Cytochrome-c oxidase Francci3_2009 162 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 86741166 Common - hypothetical protein Francci3_2470 12 None None None 86742148 Common - Succinate dehydrogenase, cytochrome b558 subunit Francci3_3465 30 None None None 86740694 Common - Methionine synthase, vitamin-B12 independent Francci3_1991 57 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 86738771 Common - adenylate/guanylate cyclase Francci3_0048 96 COG3899 COG3899, Predicted ATPase General function prediction only 86741425 Nonpathogen - hypothetical protein Francci3_2736 1 None None None 86742026 Nonpathogen - hypothetical protein Francci3_3340 1 None None None 86739277 Common - hypothetical protein Francci3_0564 31 COG2030 MaoC, Acyl dehydratase Lipid metabolism 86741762 Common thiG thiazole synthase Francci3_3076 166 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 86742542 Common - peptidase S1 and S6, chymotrypsin/Hap Francci3_3863 220 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 86742757 Nonpathogen - hypothetical protein Francci3_4080 1 None None None 86740455 Common - 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases-like Francci3_1750 144 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 86740794 Common - aldo/keto reductase Francci3_2093 206 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 86739863 Common - two component transcriptional regulator, winged helix family Francci3_1155 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86740347 Common - hypothetical protein Francci3_1642 19 None None None 86742238 Common - bifunctional riboflavin kinase/FMN adenylyltransferase Francci3_3557 209 COG0196 RibF, FAD synthase Coenzyme metabolism 86741701 Common trpA tryptophan synthase subunit alpha Francci3_3015 213 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 86741890 Common - transcriptional regulator, XRE family Francci3_3204 7 COG1396 HipB, Predicted transcriptional regulators Transcription 86742248 Nonpathogen - hypothetical protein Francci3_3567 1 None None None 86739225 Common - ResB-like Francci3_0512 19 COG1333 ResB, ResB protein required for cytochrome c biosynthesis Posttranslational modification, protein turnover, chaperones 86740673 Common - transcriptional regulator, RpiR family Francci3_1970 90 COG1737 RpiR, Transcriptional regulators Transcription 86741151 Common - enoyl-CoA hydratase Francci3_2455 185 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 86740808 Nonpathogen - hypothetical protein Francci3_2107 1 None None None 86738763 Nonpathogen - hypothetical protein Francci3_0040 1 None None None 86740574 Common - hypothetical protein Francci3_1869 9 None None None 86739820 Common - cytochrome P450 Francci3_1111 71 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 86742099 Common - aldo/keto reductase Francci3_3416 199 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 86741768 Common - hypothetical protein Francci3_3082 26 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 86740165 Nonpathogen - hypothetical protein Francci3_1459 1 None None None 86739421 Common - carbonic anhydrase Francci3_0708 46 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 86739531 Common - short-chain dehydrogenase/reductase SDR Francci3_0818 235 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 86741103 Common - FMN-dependent alpha-hydroxy acid dehydrogenase Francci3_2407 109 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 86740424 Nonpathogen - hypothetical protein Francci3_1719 1 None None None 86740725 Common - transcriptional regulator, winged helix family Francci3_2022 28 COG3903 COG3903, Predicted ATPase General function prediction only 86742677 Common - transposase, IS4 Francci3_3998 42 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741014 Common - hypothetical protein Francci3_2317 22 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741451 Common - putative methyltransferase Francci3_2762 68 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86741743 Common aceE pyruvate dehydrogenase subunit E1 Francci3_3057 149 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 86740514 Common - hypothetical protein Francci3_1809 9 None None None 86739307 Common rplE 50S ribosomal protein L5 Francci3_0594 246 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 86738930 Nonpathogen - Toluene-4-monooxygenase system B Francci3_0212 1 None None None 86742073 Common - phage integrase Francci3_3390 52 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 86739146 Common - oxidoreductase-like Francci3_0430 55 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 86739074 Common - Methyltransferase type 11 Francci3_0358 141 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86738820 Common - Glu/Leu/Phe/Val dehydrogenase Francci3_0097 151 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 86741968 Common - AMP-dependent synthetase and ligase Francci3_3282 192 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86741057 Common - hypothetical protein Francci3_2361 29 COG3505 VirD4, Type IV secretory pathway, VirD4 components Intracellular trafficking and secretion 86742986 Common - D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase Francci3_4311 83 COG2027 DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) Cell envelope biogenesis, outer membrane 86742691 Common - restriction modification system DNA specificity domain Francci3_4012 66 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 86740759 Common - transposase IS66 Francci3_2057 47 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741980 Nonpathogen - 6-phosphogluconate dehydrogenase, NAD-binding Francci3_3294 1 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 86740975 Nonpathogen - hypothetical protein Francci3_2278 7 COG3875 COG3875, Uncharacterized conserved protein Function unknown 86739970 Common - coproporphyrinogen III oxidase Francci3_1263 204 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 86740536 Nonpathogen - hypothetical protein Francci3_1831 1 None None None 86742809 Common - transcriptional regulator, XRE family Francci3_4132 6 COG1396 HipB, Predicted transcriptional regulators Transcription 86741019 Common - Camphor resistance CrcB protein Francci3_2322 16 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 86741723 Common - hypothetical protein Francci3_3037 54 COG3391 COG3391, Uncharacterized conserved protein Function unknown 86742464 Nonpathogen - hypothetical protein Francci3_3784 1 None None None 86742826 Common - Integrase Francci3_4149 47 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740182 Nonpathogen - hypothetical protein Francci3_1476 1 None None None 86741862 Common pheT phenylalanyl-tRNA synthetase subunit beta Francci3_3176 220 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 86742132 Common - Tetratricopeptide TPR_4 Francci3_3449 54 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 86740546 Nonpathogen - hypothetical protein Francci3_1841 3 None None None 86742955 Common - Anion-transporting ATPase Francci3_4280 14 COG0003 ArsA, Predicted ATPase involved in chromosome partitioning Cell division and chromosome partitioning 86739997 Common - macrocin-O-methyltransferase Francci3_1291 23 None None None 86740238 Common - phosphoenolpyruvate phosphomutase Francci3_1533 98 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 86742511 Nonpathogen - hypothetical protein Francci3_3832 1 None None None 86738934 Common - carbonic anhydrase Francci3_0216 45 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 86739912 Common - Endopeptidase Clp Francci3_1205 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 86739407 Common - Peptidase M20D, amidohydrolase Francci3_0694 169 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 86740900 Nonpathogen - hypothetical protein Francci3_2202 1 None None None 86740895 Common - RNA-directed DNA polymerase Francci3_2197 90 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 86740510 Nonpathogen - hypothetical protein Francci3_1805 1 None None None 86742747 Common - LmbE-like protein Francci3_4069 19 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 86741614 Common - biotin/lipoyl attachment Francci3_2927 165 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 86741363 Nonpathogen - protein of unknown function DUF402 Francci3_2672 4 None None None 86742225 Common - dihydrodipicolinate synthase Francci3_3544 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 86739289 Common - Uracil-DNA glycosylase superfamily Francci3_0576 29 COG3663 Mug, G:T/U mismatch-specific DNA glycosylase DNA replication, recombination, and repair 86741018 Common - major facilitator superfamily MFS_1 Francci3_2321 26 None None None 86743148 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit beta Francci3_4473 109 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 86739722 Common - Acyl-CoA dehydrogenase Francci3_1010 46 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 86742285 Common - protein of unknown function DUF177 Francci3_3604 43 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 86742912 Nonpathogen - hypothetical protein Francci3_4237 1 None None None 86742114 Common - Resolvase-like Francci3_3431 21 COG2452 COG2452, Predicted site-specific integrase-resolvase DNA replication, recombination, and repair 86740633 Common - AMP-dependent synthetase and ligase Francci3_1929 169 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86738951 Common - ApbE-like lipoprotein Francci3_0233 91 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 86742334 Common - ROK Francci3_3653 54 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 86740231 Nonpathogen - ATPase Francci3_1526 2 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 86743008 Common - protein of unknown function, ATP binding Francci3_4333 31 COG2229 COG2229, Predicted GTPase General function prediction only 86738843 Common - response regulator receiver protein Francci3_0120 8 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86740464 Common - amidinotransferase Francci3_1759 14 COG1834 COG1834, N-Dimethylarginine dimethylaminohydrolase Amino acid transport and metabolism 86741907 Common - hypothetical protein Francci3_3221 5 None None None 86740144 Common - hypothetical protein Francci3_1438 178 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 86741090 Nonpathogen - hypothetical protein Francci3_2394 1 COG1621 SacC, Beta-fructosidases (levanase/invertase) Carbohydrate transport and metabolism 86742854 Common - protein of unknown function DUF347 Francci3_4177 27 COG4705 COG4705, Uncharacterized membrane-anchored protein conserved in bacteria Function unknown 86741900 Common alaS alanyl-tRNA synthetase Francci3_3214 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86740043 Nonpathogen - hypothetical protein Francci3_1337 1 None None None 86739166 Nonpathogen - hypothetical protein Francci3_0451 1 None None None 86741486 Common - transposase, IS4 Francci3_2799 28 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86740191 Common - putative signal transduction histidine kinase Francci3_1486 145 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 86740862 Common - short-chain dehydrogenase/reductase SDR Francci3_2163 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 86741181 Common - Prephenate dehydratase Francci3_2485 212 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 86740148 Common - hypothetical protein Francci3_1442 13 COG2026 RelE, Cytotoxic translational repressor of toxin-antitoxin stability system Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning 86739957 Nonpathogen - hypothetical protein Francci3_1250 1 None None None 86742972 Common - type II secretion system protein E Francci3_4297 156 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 86742498 Common - hypothetical protein Francci3_3819 5 None None None 86742901 Common - hypothetical protein Francci3_4226 71 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739220 Common - glutamate-1-semialdehyde aminotransferase Francci3_0507 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 86740189 Common - cysteine dioxygenase type I Francci3_1484 8 COG5553 COG5553, Predicted metal-dependent enzyme of the double-stranded beta helix superfamily General function prediction only 86743202 Common - hypothetical protein Francci3_4527 9 None None None 86742187 Common - sigma 38 Francci3_3505 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 86740515 Common - uncharacterized FAD-dependent dehydrogenase Francci3_1810 36 COG2509 COG2509, Uncharacterized FAD-dependent dehydrogenases General function prediction only 86741919 Common - Methyltransferase type 11 Francci3_3233 28 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86742300 Common - histone-like DNA-binding protein Francci3_3619 210 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 86742195 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Francci3_3513 16 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 86742436 Nonpathogen - hypothetical protein Francci3_3756 1 None None None 86742930 Common - transcriptional regulator, CarD family Francci3_4255 84 COG1329 COG1329, Transcriptional regulators, similar to M. xanthus CarD Transcription 86739917 Common - Nucleoside-diphosphate kinase Francci3_1210 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 86740616 Common - ErfK/YbiS/YcfS/YnhG Francci3_1911 21 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 86743127 Common - hypothetical protein Francci3_4452 8 None None None 86741804 Common - aminotransferase, class V Francci3_3118 233 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 86740051 Common - hypothetical protein Francci3_1345 21 COG1985 RibD, Pyrimidine reductase, riboflavin biosynthesis Coenzyme metabolism 86741636 Common - Catalase Francci3_2949 127 COG0753 KatE, Catalase Inorganic ion transport and metabolism 86741280 Common - hypothetical protein Francci3_2589 4 None None None 86742265 Common - DNA processing protein DprA, putative Francci3_3584 209 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 86742925 Common - FHA domain containing protein Francci3_4250 9 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 86742705 Common - AMP-dependent synthetase and ligase Francci3_4026 220 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 86743215 Common - parB-like partition proteins Francci3_4540 185 COG1475 Spo0J, Predicted transcriptional regulators Transcription 86742513 Common - O-methyltransferase, family 3 Francci3_3834 96 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 86739017 Common - transcriptional regulator, XRE family Francci3_0301 4 COG1396 HipB, Predicted transcriptional regulators Transcription 86742568 Common - HAD-superfamily hydrolase, subfamily IIA Francci3_3889 103 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 86738827 Common - putative DNA-binding protein Francci3_0104 31 None None None 86741331 Common - protein of unknown function DUF75 Francci3_2640 21 COG2047 COG2047, Uncharacterized protein (ATP-grasp superfamily) General function prediction only 86740498 Common - Phosphoesterase PHP-like Francci3_1793 93 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 86741642 Common - bacteriophage (phiC31) resistance gene PglZ Francci3_2955 9 None None None 86743035 Nonpathogen - hypothetical protein Francci3_4360 1 None None None 86739347 Common - transcription factor WhiB Francci3_0634 9 None None None 86740942 Common - AMP-dependent synthetase and ligase Francci3_2245 222 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86739281 Common - NusG antitermination factor Francci3_0568 215 COG0250 NusG, Transcription antiterminator Transcription 86741188 Common - hypothetical protein Francci3_2492 18 None None None 86739767 Common - acyltransferase 3 Francci3_1056 63 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 86741124 Common - MmgE/PrpD Francci3_2428 30 COG2079 PrpD, Uncharacterized protein involved in propionate catabolism General function prediction only 161353753 Common - putative alpha-isopropylmalate/homocitrate synthase family transferase Francci3_3628 209 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 86739041 Common - putative signal transduction histidine kinase Francci3_0325 29 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 86742452 Common - GTPase EngC Francci3_3772 163 COG1162 COG1162, Predicted GTPases General function prediction only 86741547 Common - periplasmic sensor signal transduction histidine kinase Francci3_2860 64 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 86740452 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Francci3_1747 21 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 86741179 Common - poly-gamma-glutamate synthesis protein Francci3_2483 50 COG2843 PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) Cell envelope biogenesis, outer membrane 86741289 Common - cation diffusion facilitator family transporter Francci3_2598 45 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 86742427 Common - thiamine monophosphate kinase Francci3_3747 177 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 86740337 Common - hypothetical protein Francci3_1632 6 None None None 86739657 Common - short-chain dehydrogenase/reductase SDR Francci3_0944 114 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 86738941 Common - DegT/DnrJ/EryC1/StrS aminotransferase Francci3_0223 193 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 86739457 Nonpathogen - hypothetical protein Francci3_0744 1 None None None 86739718 Common - gas vesicle synthesis-like protein Francci3_1006 22 None None None 86742365 Common - protein of unknown function DUF77 Francci3_3684 40 COG0011 COG0011, Uncharacterized conserved protein Function unknown 86742652 Common - FHA domain containing protein Francci3_3973 5 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 86743101 Common - cold-shock DNA-binding domain protein Francci3_4426 169 COG1278 CspC, Cold shock proteins Transcription 86739760 Common - high-affinity nickel-transporter Francci3_1049 38 COG3376 HoxN, High-affinity nickel permease Inorganic ion transport and metabolism 86741357 Common - MMPL Francci3_2666 41 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 86738882 Common - luciferase-like Francci3_0161 38 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 86739101 Common - hypothetical protein Francci3_0385 8 COG3655 COG3655, Predicted transcriptional regulator Transcription 86740473 Common - major facilitator superfamily MFS_1 Francci3_1768 120 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 86743045 Common - phosphoribosylamine--glycine ligase Francci3_4370 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 86740100 Common - hypothetical protein Francci3_1394 7 COG2324 COG2324, Predicted membrane protein Function unknown 86739584 Common - beta-lactamase-like Francci3_0871 99 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 86742937 Common - Phosphate transport system permease protein 1 Francci3_4262 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 86742143 Common - Pyridoxal-5'-phosphate-dependent enzyme, beta subunit Francci3_3460 200 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 86739415 Common - membrane-flanked domain Francci3_0702 17 COG3402 COG3402, Uncharacterized conserved protein Function unknown 86739410 Common - hypothetical protein Francci3_0697 6 None None None 86739465 Common - protein of unknown function DUF343 Francci3_0752 31 COG2835 COG2835, Uncharacterized conserved protein Function unknown 86743161 Common - nitrogenase molybdenum-iron protein beta chain Francci3_4486 54 COG2710 NifD, Nitrogenase molybdenum-iron protein, alpha and beta chains Energy production and conversion 86741651 Nonpathogen - hypothetical protein Francci3_2964 1 None None None 86742163 Common - S-malonyltransferase Francci3_3481 203 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 86741806 Common - Adenosine kinase Francci3_3120 121 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 86739562 Nonpathogen - hypothetical protein Francci3_0849 4 None None None 86742881 Common - AMP-dependent synthetase and ligase Francci3_4204 222 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86739438 Common - hydrolase (HAD superfamily)-like Francci3_0725 17 COG5610 COG5610, Predicted hydrolase (HAD superfamily) General function prediction only 86739169 Common - hypothetical protein Francci3_0454 5 COG2044 COG2044, Predicted peroxiredoxins General function prediction only 86739572 Nonpathogen - hypothetical protein Francci3_0859 1 None None None 86741626 Common - TrkA-N Francci3_2939 64 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 86739569 Nonpathogen - hypothetical protein Francci3_0856 1 None None None 86743051 Common - aspartate 1-decarboxylase Francci3_4376 127 COG0853 PanD, Aspartate 1-decarboxylase Coenzyme metabolism 86738871 Common - sigma-24 Francci3_0148 78 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 86741440 Common - putative transcriptional regulator Francci3_2751 59 COG1733 COG1733, Predicted transcriptional regulators Transcription 86741989 Nonpathogen - hypothetical protein Francci3_3303 1 None None None 86740925 Common - phage shock protein A, PspA Francci3_2228 62 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 86741196 Common - transcriptional regulator, MarR family Francci3_2500 71 COG1846 MarR, Transcriptional regulators Transcription 86743212 Common - thioredoxin Francci3_4537 233 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 86739378 Common - protein of unknown function DUF1003 Francci3_0665 45 COG4420 COG4420, Predicted membrane protein Function unknown 86739604 Common - alpha/beta hydrolase fold Francci3_0891 95 COG2267 PldB, Lysophospholipase Lipid metabolism 86742153 Common - hypothetical protein Francci3_3471 9 None None None 86741538 Common - beta-ketoacyl synthase Francci3_2851 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86740401 Common - NLP/P60 Francci3_1696 136 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 86741521 Common - extracellular solute-binding protein, family 1 Francci3_2834 111 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 86739817 Common - transposase, IS4 Francci3_1108 24 None None None 86740435 Nonpathogen - response regulator receiver and SARP domain protein Francci3_1730 4 COG3947 COG3947, Response regulator containing CheY-like receiver and SARP domains Signal transduction mechanisms 86741833 Common thrS threonyl-tRNA synthetase Francci3_3147 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86740312 Common - Stearoyl-CoA 9-desaturase Francci3_1607 68 COG1398 OLE1, Fatty-acid desaturase Lipid metabolism 86738770 Nonpathogen - hypothetical protein Francci3_0047 1 None None None 86739093 Common - diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with GAF sensor Francci3_0377 176 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 86739215 Nonpathogen - hypothetical protein Francci3_0501 1 None None None 86739882 Nonpathogen - hypothetical protein Francci3_1174 1 None None None 86742787 Common - Integrase Francci3_4110 49 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739393 Common - putative succinate dehydrogenase membrane subunit Francci3_0680 13 COG2142 SdhD, Succinate dehydrogenase, hydrophobic anchor subunit Energy production and conversion 86741463 Common - Endopeptidase Clp Francci3_2774 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 86739125 Common - Peptidoglycan-binding LysM Francci3_0409 7 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 86740389 Common - Resolvase-like Francci3_1684 147 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 86740532 Common - hypothetical protein Francci3_1827 7 None None None 86738898 Nonpathogen - hypothetical protein Francci3_0177 1 COG2261 COG2261, Predicted membrane protein Function unknown 86740959 Nonpathogen - hypothetical protein Francci3_2262 1 None None None 86741316 Nonpathogen - hypothetical protein Francci3_2625 1 None None None 86742609 Common - Nucleotidyl transferase Francci3_3930 128 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 86739296 Common rplD 50S ribosomal protein L4 Francci3_0583 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 86739255 Common - NADH dehydrogenase subunit E Francci3_0542 155 COG1905 NuoE, NADH:ubiquinone oxidoreductase 24 kD subunit Energy production and conversion 86740486 Common - protein of unknown function DUF397 Francci3_1781 6 None None None 86739001 Common - NLP/P60 Francci3_0285 130 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 86741083 Nonpathogen - hypothetical protein Francci3_2387 9 None None None 86738973 Common - cytochrome bd ubiquinol oxidase, subunit I Francci3_0256 167 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 86742102 Common - serine/threonine protein kinase with WD40 repeats Francci3_3419 160 COG2319 COG2319, FOG: WD40 repeat General function prediction only 86742122 Nonpathogen - hypothetical protein Francci3_3439 3 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 86739391 Common sdhB succinate dehydrogenase iron-sulfur subunit Francci3_0678 204 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 86739985 Common - transketolase Francci3_1278 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 86741466 Nonpathogen - hypothetical protein Francci3_2778 1 None None None 86742797 Common - transposase, IS4 Francci3_4120 31 None None None 86741077 Nonpathogen - Cytidylate kinase-like Francci3_2381 11 COG1102 Cmk, Cytidylate kinase Nucleotide transport and metabolism 86741369 Common - Prevent-host-death protein Francci3_2678 11 COG2161 StbD, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 86742573 Nonpathogen - hypothetical protein Francci3_3894 1 None None None 86742491 Nonpathogen - hypothetical protein Francci3_3812 1 None None None 86740869 Common - LAO/AO transport system ATPase Francci3_2170 99 COG1703 ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family Amino acid transport and metabolism 86743170 Common - peptidase M52, hydrogen uptake protein Francci3_4495 33 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 86740358 Common - cytochrome oxidase assembly Francci3_1653 18 COG1612 CtaA, Uncharacterized protein required for cytochrome oxidase assembly Posttranslational modification, protein turnover, chaperones 86740777 Common - aminotransferase class-III Francci3_2075 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 86740843 Common - Hemerythrin HHE cation binding region Francci3_2142 8 None None None 86740457 Common - GMP reductase Francci3_1752 233 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 86741088 Common - protein of unknown function DUF182 Francci3_2392 113 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 86742014 Nonpathogen - hypothetical protein Francci3_3328 1 None None None 86739191 Common - pyrroline-5-carboxylate reductase Francci3_0476 214 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 86739749 Common - aldehyde dehydrogenase Francci3_1038 213 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 86743032 Common - membrane-flanked domain Francci3_4357 32 COG3402 COG3402, Uncharacterized conserved protein Function unknown 86740645 Common - NADH ubiquinone oxidoreductase, 20 kDa subunit Francci3_1941 77 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 86740827 Common - hypothetical protein Francci3_2126 39 None None None 86740876 Common - transcriptional regulator, TetR family Francci3_2177 8 COG1309 AcrR, Transcriptional regulator Transcription 86742474 Common - peptidase M16-like Francci3_3795 149 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 86740697 Common - Phytanoyl-CoA dioxygenase Francci3_1994 26 COG5285 COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin Secondary metabolites biosynthesis, transport, and catabolism 86741716 Common - periplasmic sensor signal transduction histidine kinase Francci3_3030 204 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 86742968 Common - alpha/beta hydrolase fold Francci3_4293 152 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 86741923 Common - NUDIX hydrolase Francci3_3237 34 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 86741327 Common - protein of unknown function DUF214 Francci3_2636 195 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 86743069 Common - HAD-superfamily hydrolase subfamily IIB Francci3_4394 82 COG1877 OtsB, Trehalose-6-phosphatase Carbohydrate transport and metabolism 86740564 Nonpathogen - hypothetical protein Francci3_1859 3 None None None 86742177 Common - ribonuclease BN Francci3_3495 79 COG1295 Rbn, Predicted membrane protein Function unknown 86743167 Nonpathogen - hypothetical protein Francci3_4492 1 None None None 86739670 Nonpathogen - group II intron-encoding maturase, putative Francci3_0957 1 None None None 86740604 Nonpathogen - hypothetical protein Francci3_1899 1 None None None 86738735 Common - hypothetical protein Francci3_0012 11 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 86743004 Nonpathogen - hypothetical protein Francci3_4329 1 None None None 86742629 Common - LmbE-like protein Francci3_3950 19 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 86741408 Common - putative integral membrane protein Francci3_2718 10 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 86740670 Common - transposase, IS605 OrfB Francci3_1966 70 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739262 Common - NADH dehydrogenase subunit L Francci3_0549 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 86742556 Nonpathogen - hypothetical protein Francci3_3877 1 None None None 86741430 Common - cyclic nucleotide-binding domain (cNMP-BD) protein Francci3_2741 22 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 86741660 Common - Allophanate hydrolase subunit 1 Francci3_2974 98 COG2049 DUR1, Allophanate hydrolase subunit 1 Amino acid transport and metabolism 86741437 Common - Cobyrinic acid a,c-diamide synthase Francci3_2748 204 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 86740880 Common - Cobyrinic acid a,c-diamide synthase Francci3_2181 79 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 86740020 Common valS valyl-tRNA synthetase Francci3_1314 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86740669 Common - cytochrome P450 Francci3_1965 24 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 86740856 Common - Phosphonate-binding periplasmic protein Francci3_2155 81 COG3221 PhnD, ABC-type phosphate/phosphonate transport system, periplasmic component Inorganic ion transport and metabolism 86741691 Common - methylmalonyl-CoA mutase Francci3_3005 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 86741483 Common - ATPase, E1-E2 type Francci3_2796 232 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 86741475 Nonpathogen - hypothetical protein Francci3_2788 3 None None None 86742118 Common - hypothetical protein Francci3_3435 8 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 86740593 Common - hypothetical protein Francci3_1888 97 COG0579 COG0579, Predicted dehydrogenase General function prediction only 86740559 Common - GCN5-related N-acetyltransferase Francci3_1854 15 COG3393 COG3393, Predicted acetyltransferase General function prediction only 86741714 Common - methyltransferases-like Francci3_3028 15 COG1568 COG1568, Predicted methyltransferases General function prediction only 86739039 Nonpathogen - hypothetical protein Francci3_0323 1 None None None 86742888 Common - transposase, IS204/IS1001/IS1096/IS1165 Francci3_4212 20 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740035 Common - 3-hydroxyacyl-CoA dehydrogenase, NAD-binding Francci3_1329 161 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 86740417 Nonpathogen - hypothetical protein Francci3_1712 1 None None None 86740254 Common - Butyryl-CoA dehydrogenase Francci3_1549 165 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 86741415 Common - hypothetical protein Francci3_2726 3 None None None 86739618 Nonpathogen - SpdA protein Francci3_0905 1 None None None 86740820 Common - short-chain dehydrogenase/reductase SDR Francci3_2119 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 86741732 Nonpathogen - hypothetical protein Francci3_3046 1 None None None 86739272 Common - orotate phosphoribosyltransferase Francci3_0559 170 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 86740442 Common - hypothetical protein Francci3_1737 5 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 86739008 Common - hypothetical protein Francci3_0292 15 None None None 86741373 Nonpathogen - hypothetical protein Francci3_2682 1 None None None 86741065 Common - periplasmic sensor signal transduction histidine kinase Francci3_2369 176 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 86739782 Common - hydrogenase assembly chaperone hypC/hupF Francci3_1071 86 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 86742489 Common - Cobyrinic acid a,c-diamide synthase Francci3_3810 208 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 86742444 Common - putative PAS/PAC sensor protein Francci3_3764 64 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 86742772 Nonpathogen - putative MarR-family transcriptional regulator Francci3_4095 2 None None None 86740614 Common - protein of unknown function DUF62 Francci3_1909 74 COG1912 COG1912, Uncharacterized conserved protein Function unknown 86740945 Common - transcriptional regulator, TetR family Francci3_2248 19 COG1309 AcrR, Transcriptional regulator Transcription 86739138 Common - ammonium transporter Francci3_0422 201 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 86741846 Common - hemolysin A Francci3_3160 130 COG1189 COG1189, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 86739443 Common - glycosyl transferase, family 2 Francci3_0730 191 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86742387 Common - H+-transporting two-sector ATPase, delta/epsilon subunit Francci3_3706 10 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 86740351 Common - Glucose-6-P dehydrogenase subunit-like Francci3_1646 29 COG3429 COG3429, Glucose-6-P dehydrogenase subunit Carbohydrate transport and metabolism 86741387 Nonpathogen - hypothetical protein Francci3_2697 1 None None None 86740860 Common - hypothetical protein Francci3_2160 5 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 86740985 Common - putative transcriptional regulator, Fis family Francci3_2288 87 COG3829 RocR, Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains Transcription / Signal transduction mechanisms 86743060 Nonpathogen - hypothetical protein Francci3_4385 1 None None None 86739773 Nonpathogen - membrane protein Francci3_1062 3 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 86741392 Common - transcriptional regulator, XRE family Francci3_2702 6 COG1396 HipB, Predicted transcriptional regulators Transcription 86741575 Common - Haloacid dehalogenase-like hydrolase Francci3_2888 20 COG0546 Gph, Predicted phosphatases General function prediction only 86739128 Common - cell divisionFtsK/SpoIIIE Francci3_0412 191 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 86740496 Nonpathogen - ROK Francci3_1791 4 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 86738803 Nonpathogen - putative ATP/GTP binding protein Francci3_0080 3 None None None 86741321 Common - Vesicle-fusing ATPase Francci3_2630 249 COG1222 RPT1, ATP-dependent 26S proteasome regulatory subunit Posttranslational modification, protein turnover, chaperones 86739797 Common - helicase-like Francci3_1086 175 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 86740243 Common - hypothetical protein Francci3_1538 10 None None None 86739157 Common - GCN5-related N-acetyltransferase Francci3_0442 16 COG0456 RimI, Acetyltransferases General function prediction only 86742612 Nonpathogen - hypothetical protein Francci3_3933 2 None None None 86741873 Common - riboflavin synthase subunit alpha Francci3_3187 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 86740394 Nonpathogen - hypothetical protein Francci3_1689 1 None None None 86741931 Common - Carbonate dehydratase Francci3_3245 182 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 86741841 Nonpathogen - hypothetical protein Francci3_3155 2 None None None 86739687 Nonpathogen - hypothetical protein Francci3_0974 2 None None None 86740110 Common - protein of unknown function DUF58 Francci3_1404 50 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 86740589 Common - protein of unknown function DUF86 Francci3_1884 49 COG2361 COG2361, Uncharacterized conserved protein Function unknown 86742721 Common - hypothetical protein Francci3_4042 24 COG2331 COG2331, Uncharacterized protein conserved in bacteria Function unknown 86740658 Nonpathogen - hypothetical protein Francci3_1954 1 None None None 86742892 Common - transposase IS116/IS110/IS902 Francci3_4216 28 None None None 86741398 Common - transposase, IS4 Francci3_2708 28 None None None 86738833 Common - putative DNA helicase Francci3_0110 37 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 86739549 Common - molybdopterin dehydrogenase, FAD-binding Francci3_0836 75 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 86742016 Common - type II secretion system protein Francci3_3330 7 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 86739661 Common - serine/threonine protein kinase Francci3_0948 201 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86742995 Common - hypothetical protein Francci3_4320 33 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 86740398 Common - Type IV secretory pathway VirB4 components-like Francci3_1693 90 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 86740375 Common - ABC transporter related Francci3_1670 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 86739806 Nonpathogen - hypothetical protein Francci3_1096 1 None None None 86741946 Nonpathogen - hypothetical protein Francci3_3260 3 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 86742910 Common - peptidase S15 Francci3_4235 57 COG2936 COG2936, Predicted acyl esterases General function prediction only 86739455 Common - LPPG:Fo 2-phospho-L-lactate transferase Francci3_0742 39 COG0391 COG0391, Uncharacterized conserved protein Function unknown 86739895 Nonpathogen - hypothetical protein Francci3_1187 1 None None None 86740152 Common - serine/threonine protein kinase Francci3_1446 137 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86741813 Common - hypothetical protein Francci3_3127 8 None None None 86742841 Common - hypothetical protein Francci3_4164 8 None None None 86741951 Common - transposase IS200-like Francci3_3265 69 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 86742949 Common - phage integrase Francci3_4274 40 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86741303 Common - protein of unknown function DUF245-like Francci3_2612 16 None None None 86740651 Common - hydrogenase expression/formation protein HypD Francci3_1947 108 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 86743081 Common - dihydroneopterin aldolase Francci3_4406 95 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 86742882 Common - Fructose-bisphosphate aldolase Francci3_4205 82 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 86740139 Nonpathogen - hypothetical protein Francci3_1433 1 None None None 86741354 Common - urease accessory protein UreG Francci3_2663 127 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 86739528 Common - NUDIX hydrolase Francci3_0815 24 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 86740910 Common - hypothetical protein Francci3_2212 23 COG3458 COG3458, Acetyl esterase (deacetylase) Secondary metabolites biosynthesis, transport, and catabolism 86742433 Common - GCN5-related N-acetyltransferase Francci3_3753 67 COG0456 RimI, Acetyltransferases General function prediction only 86741162 Nonpathogen - ParB-like nuclease Francci3_2466 3 None None None 86742322 Common - penicillin-binding protein, transpeptidase Francci3_3641 203 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 86739521 Nonpathogen - hypothetical protein Francci3_0808 3 None None None 86742329 Common - Methionine synthase, vitamin-B12 independent Francci3_3648 15 None None None 86742544 Common - GTP-binding protein TypA Francci3_3865 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 86739637 Nonpathogen - hypothetical protein Francci3_0924 1 None None None 86742295 Common - Glycerol-3-phosphate dehydrogenase (NAD(P)+) Francci3_3614 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 86743137 Nonpathogen - hypothetical protein Francci3_4462 1 None None None 86742624 Common - peptidase S8 and S53, subtilisin, kexin, sedolisin Francci3_3945 138 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 86742254 Common ispG 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase Francci3_3573 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 86740074 Common - hypothetical protein Francci3_1368 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 86740591 Common - luciferase-like Francci3_1886 58 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 86740299 Nonpathogen - hypothetical protein Francci3_1594 1 COG3247 HdeD, Uncharacterized conserved protein Function unknown 86740573 Common - putative IS630 family transposase Francci3_1868 4 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739382 Common - YcfA-like Francci3_0669 21 COG1724 COG1724, Predicted periplasmic or secreted lipoprotein Cell motility and secretion 86740012 Common - oxidoreductase-like Francci3_1306 23 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 86740004 Common - glycosyltransferases-like Francci3_1298 55 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 86743049 Nonpathogen - hypothetical protein Francci3_4374 1 None None None 86741147 Common - MbtH-like protein Francci3_2451 37 COG3251 COG3251, Uncharacterized protein conserved in bacteria Function unknown 86741795 Nonpathogen - hypothetical protein Francci3_3109 3 None None None 86740210 Common - metallophosphoesterase Francci3_1505 11 COG1409 Icc, Predicted phosphohydrolases General function prediction only 86741152 Common - Enoyl-CoA hydratase/isomerase Francci3_2456 134 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 86741133 Nonpathogen - hypothetical protein Francci3_2437 1 None None None 86740465 Common - hypothetical protein Francci3_1760 5 None None None 86742185 Common - histone deacetylase superfamily Francci3_3503 159 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 86742421 Common aat leucyl/phenylalanyl-tRNA--protein transferase Francci3_3741 134 COG2360 Aat, Leu/Phe-tRNA-protein transferase Posttranslational modification, protein turnover, chaperones 86742715 Common - GCN5-related N-acetyltransferase Francci3_4036 126 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 86742504 Common - aldehyde dehydrogenase Francci3_3825 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 86742165 Common acpP acyl carrier protein Francci3_3483 207 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86738953 Common - periplasmic sensor signal transduction histidine kinase Francci3_0235 217 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 86739160 Common - thiamine S Francci3_0445 7 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 86741688 Common - serine/threonine protein kinase with WD40 repeats Francci3_3002 152 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86742057 Common - Methyltransferase type 11 Francci3_3373 7 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 86741530 Common - diphosphate--fructose-6-phosphate 1-phosphotransferase Francci3_2843 160 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 86739685 Nonpathogen - hypothetical protein Francci3_0972 1 None None None 86739775 Common - hypothetical protein Francci3_1064 8 None None None 86740257 Common - Helicase RecD/TraA Francci3_1552 156 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 86741718 Common - transcriptional regulator, BadM/Rrf2 family Francci3_3032 4 COG1959 COG1959, Predicted transcriptional regulator Transcription 86738968 Common - putative sulfonate binding protein precursor Francci3_0251 75 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 86740121 Common - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Francci3_1415 207 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 86741969 Common - osmosensitive K+ channel signal transduction histidine kinase Francci3_3283 218 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 86739025 Common - periplasmic sensor signal transduction histidine kinase Francci3_0309 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 86738773 Common - nitroreductase Francci3_0050 63 COG0778 NfnB, Nitroreductase Energy production and conversion 86742216 Common - phage shock protein A, PspA Francci3_3535 14 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 86742397 Common - glycosyl transferase, family 4 Francci3_3716 110 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 86741624 Nonpathogen - putative transcriptional regulator, TetR family Francci3_2937 10 None None None 86740310 Common - Cyclopropane-fatty-acyl-phospholipid synthase Francci3_1605 124 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 86740867 Common - MaoC-like dehydratase Francci3_2168 81 COG2030 MaoC, Acyl dehydratase Lipid metabolism 86739036 Common - periplasmic sensor signal transduction histidine kinase Francci3_0320 170 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 86739279 Common - aspartate aminotransferase Francci3_0566 237 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 86739320 Common rpsM 30S ribosomal protein S13 Francci3_0607 242 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 86740372 Common glgC glucose-1-phosphate adenylyltransferase Francci3_1667 151 COG0448 GlgC, ADP-glucose pyrophosphorylase Carbohydrate transport and metabolism 86741359 Common - Adenylate kinase and related kinases-like Francci3_2668 53 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 86741982 Common - putative transcriptional regulator Francci3_3296 21 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 86739861 Common - HNH endonuclease Francci3_1153 94 COG1403 McrA, Restriction endonuclease Defense mechanisms 86740247 Nonpathogen - hypothetical protein Francci3_1542 1 None None None 86740332 Common - putative conserved transmembrane alanine and leucine rich protein Francci3_1627 5 COG0517 COG0517, FOG: CBS domain General function prediction only 86741657 Common - transcriptional regulator, MarR family Francci3_2971 6 COG1846 MarR, Transcriptional regulators Transcription 86743220 Common - 60 kDa inner membrane insertion protein Francci3_4545 209 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 86739696 Common - oxidoreductase, molybdopterin binding Francci3_0983 39 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 86742441 Common - 8-amino-7-oxononanoate synthase Francci3_3761 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 86741780 Common - Arsenite-transporting ATPase Francci3_3094 67 COG0003 ArsA, Predicted ATPase involved in chromosome partitioning Cell division and chromosome partitioning 86743146 Common - alkylhydroperoxidase Francci3_4471 75 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 86740934 Common - Hydantoinase/oxoprolinase Francci3_2237 102 COG0145 HyuA, N-methylhydantoinase A/acetone carboxylase, beta subunit Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86741645 Nonpathogen - transcriptional modulator of MazE/toxin, MazF Francci3_2958 1 COG2337 MazF, Growth inhibitor Signal transduction mechanisms 86740089 Common - Squalene/phytoene synthase Francci3_1383 108 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 86742049 Common - hypothetical protein Francci3_3365 15 None None None 86739327 Common rplM 50S ribosomal protein L13 Francci3_0614 224 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 86740684 Nonpathogen - hypothetical protein Francci3_1981 1 None None None 86739554 Common - hypothetical protein Francci3_0841 2 None None None 86741101 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Francci3_2405 105 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 86741561 Common - serine/threonine protein kinase Francci3_2874 135 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86741308 Nonpathogen - nucleic acid-binding protein contains PIN domain-like Francci3_2617 6 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 86742606 Nonpathogen - hypothetical protein Francci3_3927 1 None None None 86742928 Common ispF 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Francci3_4253 178 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 86742668 Common - Recombinase Francci3_3989 148 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 86739938 Common - phosphoglucomutase Francci3_1231 202 COG0033 Pgm, Phosphoglucomutase Carbohydrate transport and metabolism 86740749 Common - AMP-dependent synthetase and ligase Francci3_2046 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86741914 Common - Endonuclease/exonuclease/phosphatase Francci3_3228 9 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 86743119 Common - Peptidylprolyl isomerase Francci3_4444 192 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 86741972 Common - potassium-transporting ATPase subunit B Francci3_3286 232 COG2216 KdpB, High-affinity K+ transport system, ATPase chain B Inorganic ion transport and metabolism 86740278 Common - glycosyl transferase, family 2 Francci3_1573 10 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 86738728 Common - protein of unknown function DUF721 Francci3_0005 19 COG5512 COG5512, Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives General function prediction only 86739178 Common - binding-protein-dependent transport systems inner membrane component Francci3_0463 138 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 86742839 Common - putative replication initiation protein Francci3_4162 5 None None None 86742848 Common - phosphopantetheine-binding Francci3_4171 9 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 86742211 Nonpathogen - hypothetical protein Francci3_3530 6 None None None 86741027 Common - transposase, IS4 Francci3_2330 28 COG5433 COG5433, Transposase DNA replication, recombination, and repair 86742762 Nonpathogen - hypothetical protein Francci3_4085 1 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 86741022 Common - protein tyrosine phosphatase Francci3_2325 127 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 86740488 Common - response regulator receiver protein Francci3_1783 8 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86740130 Common ileS isoleucyl-tRNA synthetase Francci3_1424 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86739116 Common - putative signal transduction histidine kinase Francci3_0400 5 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 86740522 Common - hypothetical protein Francci3_1817 6 None None None 86743200 Common - hypothetical protein Francci3_4525 17 COG5650 COG5650, Predicted integral membrane protein Function unknown 86741047 Common - Resolvase-like Francci3_2351 130 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 86740196 Common - diguanylate cyclase (GGDEF domain) Francci3_1491 176 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 86739210 Common - Integrase Francci3_0496 49 None None None 86741169 Nonpathogen - hypothetical protein Francci3_2473 1 None None None 86739027 Common - hypothetical protein Francci3_0311 98 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 86742409 Common - response regulator receiver protein Francci3_3728 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86740967 Common - hypothetical protein Francci3_2270 18 None None None 86740080 Common secF preprotein translocase subunit SecF Francci3_1374 208 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 86739496 Nonpathogen - TadE-like Francci3_0783 1 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 86742595 Common - protein of unknown function DUF1112 Francci3_3916 28 COG4760 COG4760, Predicted membrane protein Function unknown 86739186 Common - two component transcriptional regulator, winged helix family Francci3_0471 213 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86741779 Nonpathogen - hypothetical protein Francci3_3093 1 None None None 86741215 Common - Oxidoreductase FAD-binding region Francci3_2519 179 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 86742647 Common - Protein of unknown function UPF0011 Francci3_3968 209 COG0313 COG0313, Predicted methyltransferases General function prediction only 86740847 Common - CMP/dCMP deaminase, zinc-binding Francci3_2146 149 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 86741007 Common - transcriptional regulator, TetR family Francci3_2310 19 COG1309 AcrR, Transcriptional regulator Transcription 86738866 Common - response regulator receiver protein Francci3_0143 8 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86741207 Common - multicopper oxidase, type 3 Francci3_2511 114 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 86741503 Nonpathogen - hypothetical protein Francci3_2816 3 COG0400 COG0400, Predicted esterase General function prediction only 86739235 Common - protein of unknown function DUF178 Francci3_0522 32 COG1427 COG1427, Predicted periplasmic solute-binding protein General function prediction only 86740290 Nonpathogen - Methyltransferase type 11 Francci3_1585 2 None None None 86742940 Common - Periplasmic phosphate binding protein Francci3_4265 136 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 86739246 Common - hypothetical protein Francci3_0533 86 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 86739691 Common - two component transcriptional regulator, winged helix family Francci3_0978 210 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 86741209 Common groEL chaperonin GroEL Francci3_2513 236 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 86741681 Nonpathogen - Toll-Interleukin receptor Francci3_2995 8 None None None 86739607 Nonpathogen - hypothetical protein Francci3_0894 1 None None None 86741583 Common - hypothetical protein Francci3_2896 27 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 86739198 Common - glutaredoxin 2 Francci3_0483 13 None None None 86741518 Common - homoserine O-acetyltransferase Francci3_2831 133 COG2021 MET2, Homoserine acetyltransferase Amino acid transport and metabolism 86741856 Common - transcriptional regulator, ArgR Francci3_3170 80 COG1438 ArgR, Arginine repressor Transcription 86741224 Nonpathogen - transposase Francci3_2530 3 None None None 86739707 Common - sodium/hydrogen exchanger Francci3_0995 19 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 86740731 Common - Cobyrinic acid a,c-diamide synthase Francci3_2028 204 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 86742662 Common - NUDIX hydrolase Francci3_3983 4 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 86741222 Common - sigma-24 Francci3_2528 43 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 86742079 Nonpathogen - hypothetical protein Francci3_3396 1 None None None 86742093 Nonpathogen - serine/threonine protein kinase Francci3_3410 6 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 86742346 Common - Glycogen debranching enzyme GlgX Francci3_3665 146 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 86739506 Common - bifunctional uroporphyrinogen-III synthetase/response regulator domain protein Francci3_0793 60 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 86740556 Nonpathogen - hypothetical protein Francci3_1851 1 None None None 86741052 Common - DNA primase catalytic core-like Francci3_2356 214 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 86741012 Common - hypothetical protein Francci3_2315 14 None None None 86741881 Common - Guanylate kinase Francci3_3195 214 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 86741110 Common - FAD linked oxidase-like Francci3_2414 196 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 86739471 Common - protein of unknown function DUF58 Francci3_0758 41 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 86739200 Common hemA glutamyl-tRNA reductase Francci3_0485 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 86741899 Common - Holliday junction resolvase YqgF Francci3_3213 160 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 86742685 Common - transposase, IS4 Francci3_4006 56 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86738979 Common - aspartate kinase Francci3_0262 234 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 86742538 Nonpathogen - hypothetical protein Francci3_3859 1 None None None 86740240 Common - ATPase Francci3_1535 61 COG2251 COG2251, Predicted nuclease (RecB family) General function prediction only 86741880 Common - DNA-directed RNA polymerase subunit omega Francci3_3194 22 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 86739653 Common - acyl-CoA dehydrogenase-like Francci3_0940 85 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 86740832 Nonpathogen - hypothetical protein Francci3_2131 1 None None None 86739921 Common - Peptidoglycan glycosyltransferase Francci3_1214 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 86738911 Nonpathogen - putative IS630 family transposase Francci3_0191 4 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741108 Common - Thioesterase Francci3_2412 51 COG3208 GrsT, Predicted thioesterase involved in non-ribosomal peptide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 86741253 Common - transcriptional regulator, XRE family Francci3_2562 41 COG1396 HipB, Predicted transcriptional regulators Transcription 86741604 Nonpathogen - hypothetical protein Francci3_2917 5 None None None 86739298 Common rplB 50S ribosomal protein L2 Francci3_0585 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 86741200 Common - 3-oxoacid CoA-transferase, subunit A Francci3_2504 102 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 86739750 Common - two component transcriptional regulator, LuxR family Francci3_1039 223 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86741119 Common - extracellular solute-binding protein, family 3 Francci3_2423 153 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 86741786 Common - hypothetical protein Francci3_3100 6 COG3688 COG3688, Predicted RNA-binding protein containing a PIN domain General function prediction only 86740306 Common - Fibronectin, type III Francci3_1601 26 COG3979 COG3979, Uncharacterized protein contain chitin-binding domain type 3 General function prediction only 86742733 Common - 2,4-diaminobutyrate 4-transaminase Francci3_4054 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 86741770 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Francci3_3084 73 COG3200 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 86742636 Common - protein of unknown function DUF322 Francci3_3957 38 COG1302 COG1302, Uncharacterized protein conserved in bacteria Function unknown 86742146 Common - hypothetical protein Francci3_3463 13 None None None 86740176 Common - protein of unknown function DUF151 Francci3_1470 78 COG1259 COG1259, Uncharacterized conserved protein Function unknown 86742454 Nonpathogen - glycerophosphoryl diester phosphodiesterase Francci3_3774 8 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 86739491 Common - putative PAS/PAC sensor protein Francci3_0778 22 None None None 86740017 Common - glycosyl transferase, group 1 Francci3_1311 45 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 86739243 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Francci3_0530 239 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 86740797 Nonpathogen - hypothetical protein Francci3_2096 1 None None None 86740356 Nonpathogen - putative transporter Francci3_1651 2 None None None 86741872 Common - bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein Francci3_3186 227 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 86742713 Common - putative cyclase Francci3_4034 98 COG1878 COG1878, Predicted metal-dependent hydrolase General function prediction only 86741003 Nonpathogen - hypothetical protein Francci3_2306 1 None None None 86741757 Common - thiamine biosynthesis protein ThiS Francci3_3071 7 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 86742834 Nonpathogen - hypothetical protein Francci3_4157 1 None None None 161353755 Common recO DNA repair protein RecO Francci3_1272 63 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 86739015 Common - hypothetical protein Francci3_0299 6 None None None 86742726 Common - serine/threonine protein kinase with WD40 repeats Francci3_4047 94 COG2319 COG2319, FOG: WD40 repeat General function prediction only 86738902 Common - glutamate decarboxylase Francci3_0181 69 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 86742367 Common - protein of unknown function DUF985 Francci3_3686 57 COG3542 COG3542, Uncharacterized conserved protein Function unknown 86741738 Common - phage integrase Francci3_3052 88 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 86739202 Common - Uroporphyrinogen III synthase HEM4 Francci3_0487 114 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 86741765 Common - hypothetical protein Francci3_3079 36 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86741744 Nonpathogen - hypothetical protein Francci3_3058 2 None None None 86738796 Nonpathogen - hypothetical protein Francci3_0073 1 None None None 86739889 Common - bifunctional deaminase-reductase-like Francci3_1181 86 COG1985 RibD, Pyrimidine reductase, riboflavin biosynthesis Coenzyme metabolism 86740049 Nonpathogen - hypothetical protein Francci3_1343 1 None None None 86742028 Common - hypothetical protein Francci3_3342 34 None None None 86739833 Nonpathogen - hypothetical protein Francci3_1124 1 None None None 86741427 Nonpathogen - hypothetical protein Francci3_2738 1 None None None 86740783 Common - transcriptional regulator, TetR family Francci3_2082 29 COG1309 AcrR, Transcriptional regulator Transcription 86741672 Common - asparagine synthase Francci3_2986 3 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 86742648 Common - glycosyl transferase, family 39 Francci3_3969 32 COG1928 PMT1, Dolichyl-phosphate-mannose--protein O-mannosyl transferase Posttranslational modification, protein turnover, chaperones 86743123 Nonpathogen - hypothetical protein Francci3_4448 1 None None None 86741258 Common - putative hydrolase Francci3_2567 60 COG0657 Aes, Esterase/lipase Lipid metabolism 86741708 Common - imidazoleglycerol phosphate synthase, cyclase subunit Francci3_3022 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 86742562 Common - soluble pyridine nucleotide transhydrogenase Francci3_3883 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 86742008 Common - putative ATP-binding protein Francci3_3322 5 COG3451 VirB4, Type IV secretory pathway, VirB4 components Intracellular trafficking and secretion 86738741 Common - hypothetical protein Francci3_0018 19 None None None 86742815 Common - short chain dehydrogenase Francci3_4138 238 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 86742750 Nonpathogen - hypothetical protein Francci3_4073 3 None None None 86738914 Common - protein of unknown function DUF450 Francci3_0194 118 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 86739339 Common - protein of unknown function UPF0079 Francci3_0626 147 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 86742675 Nonpathogen - hypothetical protein Francci3_3996 3 None None None 86739330 Common - D-fructose-6-phosphate amidotransferase Francci3_0617 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 86741582 Common - hypothetical protein Francci3_2895 21 None None None 86738760 Nonpathogen - hypothetical protein Francci3_0037 2 None None None 86738856 Nonpathogen - hypothetical protein Francci3_0133 1 None None None 86742580 Common leuS leucyl-tRNA synthetase Francci3_3901 246 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 86739759 Common - Pirin-like Francci3_1048 142 COG1741 COG1741, Pirin-related protein General function prediction only 86740362 Common - glycerol kinase Francci3_1657 179 COG0554 GlpK, Glycerol kinase Energy production and conversion 86742860 Common - sigma-24 Francci3_4183 42 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 86741139 Common - putative phage-related terminase large subunit Francci3_2443 8 None None None 86742596 Nonpathogen - hypothetical protein Francci3_3917 1 None None None 86740218 Common - Tetratricopeptide TPR_4 Francci3_1513 30 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 86739356 Common - hypothetical protein Francci3_0643 14 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 86743023 Common - Beta-phosphoglucomutase hydrolase Francci3_4348 129 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 86740067 Common - elongation factor G Francci3_1361 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 86738927 Common - NADPH-dependent FMN reductase Francci3_0209 90 COG0431 COG0431, Predicted flavoprotein General function prediction only 86740322 Common - protein of unknown function DUF899, thioredoxin-like Francci3_1617 26 COG4312 COG4312, Uncharacterized protein conserved in bacteria Function unknown 86739113 Common - protein of unknown function DUF397 Francci3_0397 6 None None None 86740754 Common - transposase IS66 Francci3_2051 39 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739959 Common - phospholipid/glycerol acyltransferase Francci3_1252 131 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 86741960 Nonpathogen - FAD dependent oxidoreductase Francci3_3274 2 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 86741059 Common - Resolvase-like Francci3_2363 120 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 86740764 Common - response regulator receiver protein Francci3_2062 8 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 86739904 Nonpathogen - hypothetical protein Francci3_1197 1 None None None 86741274 Common - Na+/H+ antiporter NhaA Francci3_2583 106 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 86741553 Common - hypothetical protein Francci3_2866 4 None None None 86742415 Common - hypothetical protein Francci3_3735 12 COG3305 COG3305, Predicted membrane protein Function unknown 86739671 Common - hypothetical protein Francci3_0958 13 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86739966 Common - DNA polymerase III, delta subunit Francci3_1259 19 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 86743182 Common - Cobyrinic acid a,c-diamide synthase Francci3_4507 189 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 86741346 Common - Methylisocitrate lyase Francci3_2655 123 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 86740470 Common - sulfatase Francci3_1765 73 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 86742339 Common - electron transfer flavoprotein, alpha subunit Francci3_3658 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 86739368 Nonpathogen - hypothetical protein Francci3_0655 1 None None None 86738991 Nonpathogen - hypothetical protein Francci3_0275 1 None None None 86741122 Common - serine O-acetyltransferase Francci3_2426 191 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 86742068 Common - transposase, IS4 Francci3_3385 56 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 86740232 Common - Propionyl-CoA carboxylase Francci3_1527 143 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 86741237 Common - hypothetical protein Francci3_2544 3 None None None 86739057 Common - Extracellular ligand-binding receptor Francci3_0341 132 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 86742745 Nonpathogen - hypothetical protein Francci3_4066 1 COG3263 COG3263, NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain Inorganic ion transport and metabolism 86742080 Common - putative regulatory protein Francci3_3397 3 None None None 86742031 Common - CRISPR-associated protein Cas4 Francci3_3345 49 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 86742963 Common - hypothetical protein Francci3_4288 6 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 86740624 Common - transcriptional regulator, LysR family Francci3_1919 184 COG0583 LysR, Transcriptional regulator Transcription 86740635 Common - transcriptional regulator, LysR family Francci3_1931 176 COG0583 LysR, Transcriptional regulator Transcription