Candidatus Blochmannia pennsylvanicus str. BPEN, complete genome NC_007292 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 71892027 Common clpP ATP-dependent Clp protease proteolytic subunit BPEN_253 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 71892195 Common asnC asparaginyl-tRNA synthetase BPEN_433 193 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 71892103 Common ybfF putative enzyme with alpha/beta-Hydrolase domain BPEN_334 80 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 71891847 Common dnaG DNA primase BPEN_058 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 71891985 Common rplN 50S ribosomal protein L14 BPEN_208 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 71891880 Common ispB octaprenyl-diphosphate synthase BPEN_095 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 71891864 Common orn oligoribonuclease BPEN_077 88 COG1949 Orn, Oligoribonuclease (3'->5' exoribonuclease) RNA processing and modification 71892266 Common nuoA NADH dehydrogenase I chain A BPEN_509 134 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 71892143 Common lpp murein lipoprotein BPEN_375 17 COG4238 COG4238, Murein lipoprotein Cell envelope biogenesis, outer membrane 71892063 Common lpxD UDP-3-O-(3-hydroxymyristoyl)-glucosamine N-acyltransferase BPEN_289 156 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 71892325 Common rpoC DNA-directed RNA polymerase subunit beta' BPEN_576 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 71892113 Common tolQ TolQ BPEN_345 147 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 71891816 Common pitA low-affinity phosphate transport protein (PiT family) BPEN_024 157 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 71891850 Common ygiH hypothetical protein BPEN_061 170 COG0344 COG0344, Predicted membrane protein Function unknown 71892020 Common thiI thiamine biosynthesis protein ThiI BPEN_246 94 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 71892182 Common acpP acyl carrier protein BPEN_415 178 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 71892362 Common rpmE 50S ribosomal protein L31 BPEN_621 160 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 71892034 Common speB agmatinase BPEN_260 153 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 71892229 Common aspS aspartyl-tRNA synthetase BPEN_467 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 71892134 Common pheS phenylalanine tRNA synthetase, alpha-subunit BPEN_366 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 71892096 Common ybeX putative integral membrane protein with CBS regulatory domain BPEN_323 219 COG4535 CorC, Putative Mg2+ and Co2+ transporter CorC Inorganic ion transport and metabolism 71892345 Common yigL predicted hydrolase BPEN_596 107 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 71892166 Common infA translation initiation factor IF-1 BPEN_399 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 71891831 Nonpathogen - conserved hypothetical protein (NT02BF0038) BPEN_040 1 None None None 71892222 Common manY PTS family enzyme IIC, mannose-specific BPEN_460 35 COG3715 ManY, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC Carbohydrate transport and metabolism 71892375 Common coaD CMP-deoxy-D-manno-octulosonate-lipid A transferase BPEN_634 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 71891990 Common rplF 50S ribosomal protein L6 BPEN_213 217 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 71891803 Common glmU N-acetyl glucosamine-1-phosphate uridyltransferase BPEN_010 233 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 71892370 Common yibN putative Rhodanese-related sulfurtransferase BPEN_629 62 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 71892387 Common dsbA periplasmic protein disulfide isomerase I BPEN_646 65 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 71891939 Common lpdA dihydrolipoamide dehydrogenase, FAD/NAD(P)-binding, E3 component of the 2-oxoglutarate dehydrogenase and the pyruvate dehydrogenase complexes BPEN_156 241 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 71892244 Common metG methionyl-tRNA synthetase BPEN_486 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 71892204 Common trpB tryptophan synthase subunit beta BPEN_442 226 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 71892246 Common rplY 50S ribosomal protein L25 BPEN_488 63 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 71892032 Common yqgE hypothetical protein BPEN_258 129 COG1678 COG1678, Putative transcriptional regulator Transcription 71892338 Common trpS tryptophanyl-tRNA synthetase BPEN_589 228 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 71892233 Common gutQ D-arabinose 5-phosphate isomerase BPEN_474 143 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 71892112 Common sucD succinyl-CoA synthetase, alpha chain BPEN_344 213 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 71891968 Common rluD pseudouridine synthase BPEN_187 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 71892180 Common tmk thymidylate kinase BPEN_413 228 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 71892056 Common frr ribosome recycling factor BPEN_282 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 71891927 Common murD UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase BPEN_144 211 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 71892269 Common truA tRNA pseudouridine synthase A BPEN_512 234 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 71892054 Common tsf elongation factor Ts BPEN_280 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 71891901 Common dnaK DnaK BPEN_118 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 71891976 Common rplD 50S ribosomal protein L4 BPEN_199 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 71891871 Common hflC FtsH protease regulator HflC BPEN_085 166 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 71891826 Common holC DNA polymerase III, chi subunit BPEN_034 30 COG2927 HolC, DNA polymerase III, chi subunit DNA replication, recombination, and repair 71891967 Common yfiO putative lipoprotein BPEN_186 114 COG4105 ComL, DNA uptake lipoprotein General function prediction only 71892337 Common pabA aminodeoxychorismate synthase subunit II BPEN_588 237 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 71892353 Common ilvC ketol-acid reductoisomerase BPEN_609 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 71892123 Common pth peptidyl-tRNA hydrolase BPEN_355 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 71892305 Common yfgB putative pyruvate formate lyase activating enzyme 2 BPEN_552 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 71892255 Common nuoM NADH dehydrogenase I chain M, membrane subunit BPEN_498 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 71891858 Common cutA periplasmic divalent cation tolerance protein BPEN_071 91 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 71891980 Common rplV 50S ribosomal subunit protein L22 BPEN_203 222 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 71891956 Common nlpD lipoprotein NlpD precursor BPEN_173 188 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 71892281 Common cysA sulfate/thiosulfate transporter subunit BPEN_528 249 COG1118 CysA, ABC-type sulfate/molybdate transport systems, ATPase component Inorganic ion transport and metabolism 71892082 Common apt adenine phosphoribosyltransferase BPEN_308 183 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 71891893 Common truB tRNA pseudouridine 5S synthase BPEN_110 245 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 71892252 Common nrdB ribonucleotide-diphosphate reductase subunit beta BPEN_495 148 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 71891820 Common ssb ssDNA-binding protein controls activity of RecBCD nuclease BPEN_028 213 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 71892094 Common leuS leucyl-tRNA synthetase BPEN_321 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 71891834 Common yhbG putative transport protein (ABC superfamily, atp_bind) BPEN_043 249 COG1137 YhbG, ABC-type (unclassified) transport system, ATPase component General function prediction only 71892044 Common lysS lysyl-tRNA synthetase BPEN_270 249 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 71892162 Common serS seryl-tRNA synthetase BPEN_395 245 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 71891866 Common amiB N-acetylmuramoyl-L-alanine amidase BPEN_080 175 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 71892283 Common cysU sulfate/thiosulfate transporter subunit BPEN_530 210 COG0555 CysU, ABC-type sulfate transport system, permease component Posttranslational modification, protein turnover, chaperones 71891943 Common yadR hypothetical protein BPEN_160 166 COG0316 IscA, Uncharacterized conserved protein Function unknown 71892264 Common nuoCD bifunctional NADH:ubiquinone oxidoreductase subunit C/D BPEN_507 191 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 71891876 Common rplI 50S ribosomal protein L9 BPEN_090 216 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 71891946 Common cysJ sulfite reductase, alpha subunit (flavoprotein) BPEN_163 102 COG0369 CysJ, Sulfite reductase, alpha subunit (flavoprotein) Inorganic ion transport and metabolism 71891801 Common atpD F0F1 ATP synthase subunit beta BPEN_008 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 71891848 Common rpsU 30S ribosomal subunit protein S21 BPEN_059 146 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 71891841 Common rplM 50S ribosomal protein L13 BPEN_050 217 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 71892016 Common nusB transcription antitermination protein NusB BPEN_242 187 COG0781 NusB, Transcription termination factor Transcription 71892025 Common cyoB cytochrome o ubiquinol oxidase, subunit I BPEN_251 163 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 71892011 Common yajC preprotein translocase, auxillary membrane component BPEN_237 164 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 71892105 Common sdhC succinate dehydrogenase cytochrome b-556 subunit BPEN_337 37 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 71891882 Common rpmA 50S ribosomal protein L27 BPEN_097 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 71892275 Common nupC nucleoside transport protein (NUP family) BPEN_519 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 71892310 Common tadA tRNA-specific adenosine deaminase BPEN_557 208 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 71892157 Common msbA lipid transporter ATP-binding/permease protein BPEN_390 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 71892205 Common trpA tryptophan synthase subunit alpha BPEN_443 216 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 71892391 Common yigN hypothetical protein BPEN_650 128 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 71891987 Common rplE 50S ribosomal protein L5 BPEN_210 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 71891796 Common atpE F0F1 ATP synthase subunit C BPEN_003 49 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 71892190 Common lpxL lipid A biosynthesis lauroyl acyltransferase BPEN_423 88 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 71892385 Common yihA Probable GTP-binding protein BPEN_644 175 COG0218 COG0218, Predicted GTPase General function prediction only 71892000 Common rplQ 50S ribosomal protein L17 BPEN_224 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 71892077 Common mreC rod shape-determining protein BPEN_303 133 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 71891974 Common rpsJ 30S ribosomal subunit protein S10 BPEN_197 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 71892150 Common nth endonuclease III BPEN_383 237 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 71891937 Common dksA dosage-dependent dnaK suppressor protein BPEN_154 116 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 71892317 Common grpE heat shock protein 24 BPEN_564 230 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 71891852 Common bacA bacitracin resistance protein BPEN_063 198 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 71892177 Common ycfF putative protein kinase C inhibitor BPEN_410 151 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 71892164 Common ftsK cell division protein BPEN_397 200 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 71892148 Common pdxH pyridoxamine 5'-phosphate oxidase BPEN_381 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 71892225 Common htpX heat shock protein HtpX BPEN_463 187 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 71891833 Common znuB high-affinity Zn transport protein (ABC superfamily, membrane) BPEN_042 183 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 71892171 Common trmU tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase BPEN_404 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 71892347 Common yigB putative hydrolase of the HAD superfamily BPEN_599 55 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 71892058 Common uppS undecaprenyl pyrophosphate synthetase BPEN_284 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 71891923 Common ftsI division-specific transpeptidase BPEN_140 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 71891878 Common ytfN hypothetical protein BPEN_093 65 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 71892356 Common ilvE branched-chain amino acid aminotransferase BPEN_612 219 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 71891925 Common murF D-alanine:D-alanine-adding enzyme BPEN_142 207 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 71891999 Common rpoA DNA-directed RNA polymerase subunit alpha BPEN_223 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 71891971 Common birA biotin-[acetylCoA carboxylase] holoenzyme synthetase BPEN_190 202 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 71892125 Common ispE 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase BPEN_357 171 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 71891824 Common argI ornithine carbamoyltransferase BPEN_032 236 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 71892160 Common aroA 3-phosphoshikimate 1-carboxyvinyltransferase BPEN_393 227 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 71892327 Common rplL 50S ribosomal protein L7/L12 BPEN_578 215 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 71891961 Common rimM 16S rRNA processing protein BPEN_180 149 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 71891908 Common dapB dihydrodipicolinate reductase BPEN_125 217 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 71892231 Common mviN putative virulence factor BPEN_469 190 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 71891798 Common atpH ATP synthase, F1 sector, delta-subunit BPEN_005 147 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 71892293 Common ureG putative urease accessory protein G BPEN_540 140 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 71892079 Common tldD TldD BPEN_305 169 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 71892217 Common minE cell division topological specificity factor BPEN_455 33 COG0851 MinE, Septum formation topological specificity factor Cell division and chromosome partitioning 71891949 Common cysG 1,3-dimethyluroporphyriongen III dehydrogenase BPEN_166 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 71892368 Common secB molecular chaperone in protein export BPEN_627 107 COG1952 SecB, Preprotein translocase subunit SecB Intracellular trafficking and secretion 71891804 Common trmE tRNA modification GTPase TrmE BPEN_011 220 COG0486 ThdF, Predicted GTPase General function prediction only 71892288 Nonpathogen - conserved hypothetical protein (NT02BF0496) BPEN_535 1 COG3317 NlpB, Uncharacterized lipoprotein Cell envelope biogenesis, outer membrane 71892304 Common ispG 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase BPEN_551 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 71892013 Common secF preprotein translocase subunit SecF BPEN_239 200 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 71891989 Common rpsH 30S ribosomal protein S8 BPEN_212 217 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 71892039 Common ygfE Z-ring-associated protein BPEN_265 36 COG3027 COG3027, Uncharacterized protein conserved in bacteria Function unknown 71892065 Common lpxA UDP-N-acetylglucosamine acyltransferase BPEN_291 154 COG1043 LpxA, Acyl- acyl carrier protein 71892145 Common ydhD conserved protein with thioredoxin-like domain BPEN_378 126 COG0278 COG0278, Glutaredoxin-related protein Posttranslational modification, protein turnover, chaperones 71892210 Common hns global DNA-binding transcriptional dual regulator H-NS BPEN_448 24 COG2916 Hns, DNA-binding protein H-NS General function prediction only 71891895 Common pnp polynucleotide phosphorylase/polyadenylase BPEN_112 235 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 71891982 Common rplP 50S ribosomal protein L16 BPEN_205 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 71891915 Common surA peptidyl-prolyl cis-trans isomerase BPEN_132 63 None None None 71892257 Common nuoK NADH dehydrogenase I chain K BPEN_500 26 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 71892198 Common fabI enoyl-[acyl-carrier-protein] reductase (NADH) BPEN_436 220 COG0623 FabI, Enoyl- acyl-carrier-protein 71892238 Common hisC histidinol-phosphate aminotransferase BPEN_479 237 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 71892272 Common yfcB N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase BPEN_515 227 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 71892380 Common yicC hypothetical protein BPEN_639 137 COG1561 COG1561, Uncharacterized stress-induced protein Function unknown 71891955 Common ispF 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase BPEN_172 189 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 71892328 Common rplJ 50S ribosomal protein L10 BPEN_579 163 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 71892227 Common pykA pyruvate kinase A BPEN_465 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 71892031 Common yqgF putative endonuclease involved in recombination BPEN_257 139 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 71892341 Common aroK shikimate kinase I BPEN_592 200 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 71892249 Common gyrA DNA gyrase, subunit A BPEN_492 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 71891920 Common leuA 2-isopropylmalate synthase BPEN_137 218 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 71892038 Common ygfA putative ligase BPEN_264 160 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 71892092 Common holA DNA polymerase III, delta subunit BPEN_319 60 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 71891896 Common deaD cold-shock DeaD box ATP-dependent RNA helicase BPEN_113 239 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 71891799 Common atpA F0F1 ATP synthase subunit alpha BPEN_006 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 71892078 Common mreD rod shape-determining protein BPEN_304 45 COG2891 MreD, Cell shape-determining protein Cell envelope biogenesis, outer membrane 71892138 Common sufB cysteine desulfurase activator complex subunit SufB BPEN_370 186 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 71892273 Common aroC chorismate synthase BPEN_516 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 71891854 Common hldE bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase BPEN_065 167 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 71892118 Common ybgF putative periplasmic protein BPEN_350 102 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 71892311 Common acpS holo-[acyl-carrier-protein] synthase BPEN_558 134 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 71892041 Common visC putative monooxygenase, FAD/NAD(P)-binding domain BPEN_267 93 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 71892332 Common secE preprotein translocase subunit SecE BPEN_583 63 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 71891934 Common lpxC UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase BPEN_151 139 COG0774 LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase Cell envelope biogenesis, outer membrane 71892107 Common sdhA succinate dehydrogenase flavoprotein subunit BPEN_339 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 71892383 Common rpoZ DNA-directed RNA polymerase, subunit K/omega BPEN_642 91 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 71892240 Common hisA phosphoribosylformimino-5-aminoimidazole carboxamide ribotide BPEN_482 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 71892374 Common kdtA 3-deoxy-D-manno-octulosonic-acid transferase BPEN_633 128 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 71892131 Common infC translation initiation factor IF-3 BPEN_363 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 71891997 Common rpsK 30S ribosomal protein S11 BPEN_221 248 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 71892159 Common cmk cytidine monophosphate (CMP) kinase BPEN_392 204 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 71892122 Common ychF translation-associated GTPase BPEN_354 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 71892014 Common ribD pyrimidine deaminase/reductase BPEN_240 224 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 71891868 Common hfq host factor I BPEN_082 127 COG1923 Hfq, Uncharacterized host factor I protein General function prediction only 71892152 Common eaeH putative adhesin BPEN_385 5 None None None 71892357 Common ilvM acetolactate synthase 2 regulatory subunit BPEN_613 18 COG3978 COG3978, Acetolactate synthase (isozyme II), small (regulatory) subunit Function unknown 71891945 Common eno enolase BPEN_162 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 71892299 Common guaA bifunctional GMP synthase/glutamine amidotransferase protein BPEN_546 240 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 71892088 Common ytfF putative cationic amino acid transport protein BPEN_315 27 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 71892149 Common tyrS tyrosyl-tRNA synthetase BPEN_382 216 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 71892120 Common gpmA phosphoglycerate mutase 1 BPEN_352 159 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 71891809 Common gyrB DNA gyrase, subunit B BPEN_016 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 71891800 Common atpG F0F1 ATP synthase subunit gamma BPEN_007 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 71892046 Common ygdP dinucleoside polyphosphate hydrolase BPEN_272 111 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 71891839 Common degQ serine protease BPEN_048 223 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 71892179 Common holB DNA polymerase III, delta prime subunit BPEN_412 215 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 71891814 Common sodA superoxide dismutase (Mn) BPEN_021 206 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 71892285 Common talA transaldolase A BPEN_532 40 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 71891885 Common rrmJ Ribosomal RNA large subunit (23S) methyltransferase J BPEN_100 138 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 71892073 Common accC acetyl CoA carboxylase, biotin carboxylase subunit BPEN_299 222 COG0439 AccC, Biotin carboxylase Lipid metabolism 71891947 Common cysI sulfite reductase, beta subunit, NADPH-dependent hemoprotein BPEN_164 147 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 71892191 Common pgsA phosphotidylglycerophosphate synthetase BPEN_427 203 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 71892237 Common hisD L-histidinal:NAD+ dehydrogenase BPEN_478 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 71891907 Common ispH 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, 4Fe-4S protein BPEN_124 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 71891913 Common ksgA dimethyladenosine transferase BPEN_130 246 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 71892019 Common ispA geranyltranstransferase BPEN_245 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 71892090 Common mrdA cell elongation-specific transpeptidase of penicillin-binding protein 2 BPEN_317 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 71892127 Common prfA peptide chain release factor 1 (RF-1) BPEN_359 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 71892142 Common sufE SufE BPEN_374 92 COG2166 COG2166, SufE protein probably involved in Fe-S center assembly General function prediction only 71892212 Common sppA protease IV BPEN_450 179 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 71892002 Common def polypeptide deformylase BPEN_226 215 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 71891931 Common ftsQ cell division protein BPEN_148 72 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 71892188 Common rluC ribosomal large subunit (23S) pseudouridine synthase C BPEN_421 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 71892071 Common proS prolyl-tRNA synthetase BPEN_297 222 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 71891911 Common folA dihydrofolate reductase type I BPEN_128 147 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 71892219 Common pabB aminodeoxychorismate synthase subunit I BPEN_457 221 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 71892348 Common dapF diaminopimelate epimerase BPEN_600 201 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 71892007 Common dnaQ DNA polymerase III, epsilon subunit BPEN_232 186 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 71892321 Common smpB SsrA-binding protein BPEN_568 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 71892296 Common ureB urease subunit beta BPEN_543 96 COG0832 UreB, Urea amidohydrolase (urease) beta subunit Amino acid transport and metabolism 71892379 Common dut deoxyuridine 5'-triphosphate nucleotidohydrolase BPEN_638 179 COG0756 Dut, dUTPase Nucleotide transport and metabolism 71892023 Common cyoD cytochrome o ubiquinol oxidase, subunit IV BPEN_249 34 COG3125 CyoD, Heme/copper-type cytochrome/quinol oxidase, subunit 4 Energy production and conversion 71892302 Common engA GTP-binding protein EngA BPEN_549 218 COG1160 COG1160, Predicted GTPases General function prediction only 71892184 Common fabD malonyl CoA-acyl carrier protein transacylase BPEN_417 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 71892153 Common ubiX 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BPEN_386 152 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 71892081 Common lon DNA-binding ATP-dependent protease La BPEN_307 220 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 71892050 Common recB exonuclease V BPEN_276 190 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 71892393 Common metE 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase BPEN_652 141 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 71891973 Common bfr bacterioferritin BPEN_196 108 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 71891812 Common glyQ glycyl-tRNA synthetase subunit alpha BPEN_019 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 71892067 Common rnhB ribonuclease HII BPEN_293 207 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 71891962 Common trmD tRNA(guanine-N1)methyltransferase BPEN_181 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 71892109 Common kgd alpha-ketoglutarate decarboxylase BPEN_341 147 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 71891932 Common ftsA cell division protein FtsA BPEN_149 178 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 71892308 Common suhB putative myo-inositol-1(or 4)-monophosphatase BPEN_555 187 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 71892213 Common gapA glyceraldehyde 3-phosphate dehydrogenase A BPEN_451 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 71891995 Common rmpJ 50S ribosomal subunit protein L36 BPEN_219 120 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 71891891 Common infB translation initiation factor IF2-2 BPEN_108 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 71891863 Common psd phosphatidylserine decarboxylase proenzyme BPEN_076 94 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 71892043 Common prfB peptide chain release factor 2 (RF-2) BPEN_269 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 71892313 Common rnc RNase III BPEN_560 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 71892381 Common - putative transcriptional regulator protein (MarR family) BPEN_640 32 COG1846 MarR, Transcriptional regulators Transcription 71892135 Common pheT phenylalanine tRNA synthetase, beta-subunit BPEN_367 238 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 71892115 Common tolA TolA BPEN_347 23 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 71892036 Common fbaA fructose-bisphosphate aldolase BPEN_262 173 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 71891818 Common zur transcriptional repressor of Zn transport system (Fur family) BPEN_026 125 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 71891918 Common leuC isopropylmalate isomerase large subunit BPEN_135 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 71892343 Common asd aspartate-semialdehyde dehydrogenase BPEN_594 194 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 71892168 Common yqeI putative transcriptional regulator with C-terminal, effector domain of the bipartite response regulator BPEN_401 10 COG3710 CadC, DNA-binding winged-HTH domains Transcription 71892004 Common aroE shikimate 5-dehydrogenase BPEN_228 178 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 71892155 Common ycaR hypothetical protein BPEN_388 91 COG2835 COG2835, Uncharacterized conserved protein Function unknown 71892221 Common manX PTS family enzyme IIA/enzyme IIB, mannose-specific BPEN_459 82 COG3444 COG3444, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIB Carbohydrate transport and metabolism 71892173 Common lolE transport protein of outer membrane lipoproteins (ABC superfamily, membrane) BPEN_406 128 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 71891806 Common rnpA RNase P, protein component BPEN_013 60 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 71892193 Common yccV hypothetical protein BPEN_431 23 COG3785 COG3785, Uncharacterized conserved protein Function unknown 71892161 Common serC phosphoserine aminotransferase BPEN_394 109 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 71892278 Common cysK cysteine synthase A BPEN_525 219 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 71892263 Common nuoE NADH dehydrogenase subunit E BPEN_506 156 COG1905 NuoE, NADH:ubiquinone oxidoreductase 24 kD subunit Energy production and conversion 71892242 Common hisI phosphoribosyl-AMP cyclohydrolase BPEN_484 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 71891856 Common plsC 1-acyl-glycerol-3-phosphate acyltransferase BPEN_068 78 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 71891842 Common rpsI 30S ribosomal subunit protein S9 BPEN_051 243 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 71891845 Common yqjA hypothetical protein BPEN_055 156 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 71892101 Common glnS glutaminyl-tRNA synthetase BPEN_332 235 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 71891887 Common folP 7,8-dihydropteroate synthase BPEN_102 218 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 71891872 Common purA adenylosuccinate synthetase BPEN_086 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 71892186 Common plsX fatty acid/phospholipid synthesis protein BPEN_419 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 71892369 Common grxC glutaredoxin 3 BPEN_628 120 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 71892084 Common adk ATP-AMP transphosphorylase BPEN_310 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 71891958 Common csrA carbon storage regulator BPEN_175 83 COG1551 CsrA, Carbon storage regulator (could also regulate swarming and quorum sensing) Signal transduction mechanisms 71891903 Common rpsT 30S ribosomal subunit protein S20 BPEN_120 164 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 71892129 Common kdsA 2-dehydro-3-deoxyphosphooctonate aldolase BPEN_361 186 COG2877 KdsA, 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase Cell envelope biogenesis, outer membrane 71891822 Common gltP glutamate/aspartate:proton symporter BPEN_030 163 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 71891978 Common rplB 50S ribosomal protein L2 BPEN_201 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 71892209 Common tdk thymidine kinase BPEN_447 80 COG1435 Tdk, Thymidine kinase Nucleotide transport and metabolism 71892395 Common ftsY cell division protein BPEN_654 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 71892170 Common mntR manganese transport regulator MntR BPEN_403 89 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 71891951 Common cysN ATP-sulfurylase, subunit 1 BPEN_168 249 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 71892069 Common accA acetylCoA carboxylase, carboxytransferase subunit alpha BPEN_295 215 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 71892099 Common nagA N-acetylglucosamine-6-phosphate deacetylase BPEN_330 118 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 71892086 Common cysS cysteinyl-tRNA synthetase BPEN_312 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 71892250 Common ubiG 3-demethylubiquinone-9 3-methyltransferase BPEN_493 151 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 71892364 Common tpiA triosephosphate isomerase BPEN_623 220 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 71892271 Common fabB 3-oxoacyl-[acyl-carrier-protein] synthase I BPEN_514 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 71892287 Common dapE succinyl-diaminopimelate desuccinylase BPEN_534 196 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 71892335 Common rpsG 30S ribosomal protein S7 BPEN_586 242 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 71891874 Common rpsF 30S ribosomal subunit protein S6 BPEN_088 184 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 71891810 Common ibpA heat shock protein A BPEN_017 64 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 71892048 Common recC exonuclease V, gamma chain BPEN_274 65 COG1330 RecC, Exonuclease V gamma subunit DNA replication, recombination, and repair 71891965 Common tyrA bifunctional chorismate mutase/prephenate dehydrogenase BPEN_184 56 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 71891829 Common yjgQ putative transmembrane protein, transport BPEN_037 76 COG0795 COG0795, Predicted permeases General function prediction only 71891929 Common murG UDP-N-acetylglucosamine:N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase BPEN_146 207 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 71892052 Common map methionine aminopeptidase BPEN_278 247 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 71892401 Common hisH imidazole glycerol phosphate synthase subunit HisH BPEN_481 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 71892277 Common ligA DNA ligase BPEN_524 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 71891905 Common ileS isoleucyl-tRNA synthetase BPEN_122 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 71891795 Common atpB F0F1 ATP synthase subunit A BPEN_002 190 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 71892372 Common rfaF ADP-heptose; LPS heptosyl transferase II BPEN_631 84 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 71892309 Common glyA serine hydroxymethyltransferase BPEN_556 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 71891861 Common efp elongation factor P BPEN_074 215 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 71892202 Common trpD anthranilate synthase component II: anthranilate phosphoribosyltransferase BPEN_440 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 71891898 Common thrA bifunctional aspartokinase I/homeserine dehydrogenase I BPEN_115 234 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 71892075 Common aroQ 3-dehydroquinate dehydratase BPEN_301 169 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 71892351 Common rho transcription termination factor Rho BPEN_607 202 COG1158 Rho, Transcription termination factor Transcription 71892323 Common pssA phosphatidylserine synthase BPEN_571 36 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 71892259 Common nuoI NADH dehydrogenase subunit I BPEN_502 193 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 71892009 Common ahpC alkyl hydroperoxide reductase C22 protein BPEN_235 218 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 71892294 Common ureF putative urease accessory protein F BPEN_541 59 COG0830 UreF, Urease accessory protein UreF Posttranslational modification, protein turnover, chaperones 71891938 Common folK 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase BPEN_155 198 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 71892245 Common folE GTP cyclohydrolase I BPEN_487 176 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 71892235 Common sbcB exonuclease I BPEN_476 51 COG2925 SbcB, Exonuclease I DNA replication, recombination, and repair 71892033 Common metK S-adenosylmethionine synthetase BPEN_259 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 71892292 Nonpathogen - hypothetical protein BPEN_539 1 None None None 71892060 Common ecfE hypothetical protein BPEN_286 208 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 71891969 Common clpB ATP-dependent protease BPEN_188 216 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 71892218 Common yeaZ putative glycoprotein endopeptidase, actin-like ATPase domain BPEN_456 170 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 71892232 Common yceL multidrug resistance protein MdtH BPEN_470 104 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 71892203 Common trpC bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase BPEN_441 220 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 71892247 Common ddlA D-alanine:D-alanine ligase A BPEN_490 210 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 71891960 Common rpsP 30S ribosomal protein S16 BPEN_179 209 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 71892087 Common folD 5,10-methylene-tetrahydrofolate cyclohydrolase BPEN_313 223 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 71891870 Common hflK HflK BPEN_084 215 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 71891902 Common dnaJ DnaJ BPEN_119 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 71892055 Common pyrH uridylate kinase BPEN_281 223 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 71892165 Common trxB thioredoxin reductase BPEN_398 247 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 71892324 Common purH IMP cyclohydrolase BPEN_575 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 71892085 Common lpxH UDP-2,3-diacylglucosamine hydrolase BPEN_311 85 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 71892057 Common dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase BPEN_283 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 71891879 Common ppa inorganic pyrophosphatase BPEN_094 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 71891948 Common cysH phosphoadenosine phosphosulfate reductase BPEN_165 155 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 71892268 Common accD acetyl-CoA carboxylase beta subunit BPEN_511 219 COG0777 AccD, Acetyl-CoA carboxylase beta subunit Lipid metabolism 71892261 Common nuoG NADH dehydrogenase subunit G BPEN_504 182 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 71891954 Common ispD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase BPEN_171 190 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 71891981 Common rpsC 30S ribosomal protein S3 BPEN_204 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 71891926 Common mraY phospho-N-acetylmuramoyl-pentapeptide transferase BPEN_143 215 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 71891828 Common yjgP putative transmembrane protein, transport BPEN_036 68 COG0795 COG0795, Predicted permeases General function prediction only 71891835 Common yhbN putative transport protein (ABC superfamily, peri_bind) BPEN_044 29 COG1934 COG1934, Uncharacterized protein conserved in bacteria Function unknown 71892062 Common hlpA histone-like protein BPEN_288 69 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 71892144 Common ribE riboflavin synthase subunit alpha BPEN_377 208 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 71892367 Common gpsA glycerol-3-phosphate dehydrogenase BPEN_626 211 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 71892399 Common ytfM putative outer membrane protein BPEN_092 85 COG0729 COG0729, Outer membrane protein Cell envelope biogenesis, outer membrane 71892074 Common accB acetylCoA carboxylase, BCCP subunit BPEN_300 179 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 71891881 Common rplU 50S ribosomal protein L21 BPEN_096 188 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 71891957 Common alaS alanyl-tRNA synthetase BPEN_174 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 71892124 Common prsA ribose-phosphate pyrophosphokinase BPEN_356 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 71892306 Common ndk 3'-phosphodiesterase BPEN_553 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 71892175 Common lolC transport protein of outer membrane lipoproteins (ABC superfamily, membrane) BPEN_408 144 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 71892254 Common nuoN NADH dehydrogenase I chain N, membrane subunit BPEN_497 210 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 71892045 Common lysA diaminopimelate decarboxylase BPEN_271 217 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 71891993 Common rplO 50S ribosomal subunit protein L15 BPEN_217 199 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 71891821 Common yjcE putative sodium:hydrogen antiporter (CPA1 family) BPEN_029 101 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 71892196 Common aspC aromatic amino acid aminotransferase BPEN_434 72 COG1448 TyrB, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 71891904 Common ribF bifunctional: flavokinase; FAD synthetase BPEN_121 211 COG0196 RibF, FAD synthase Coenzyme metabolism 71892280 Common ptsI phosphoenolpyruvate-protein phosphotransferase BPEN_527 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 71891892 Common rbfA 30S ribosome-binding factor BPEN_109 102 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 71892336 Common rpsL 30S ribosomal protein S12 BPEN_587 242 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 71892289 Common dapA dihydrodipicolinate synthase BPEN_536 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 71891805 Common yidCD hypothetical protein BPEN_012 210 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 71892239 Common hisB imidazole glycerol-phosphate dehydratase/histidinol phosphatase BPEN_480 217 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 71891942 Common mrcB penicillin-binding protein 1b BPEN_159 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 71892392 Common udp uridine phosphorylase BPEN_651 94 COG2820 Udp, Uridine phosphorylase Nucleotide transport and metabolism 71892197 Common ycbL putative enzyme with metallo-hydrolase/oxidoreductase domain BPEN_435 213 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 71891865 Common yjeE putative enzyme with nucleoside triP hydrolase domain BPEN_079 187 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 71892010 Common tgt tRNA-guanine transglycosylase BPEN_236 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 71891862 Common yjeP hypothetical protein BPEN_075 161 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 71892028 Common clpX ATP-dependent protease ATP-binding subunit BPEN_254 221 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 71891859 Common groES co-chaperonin GroES BPEN_072 216 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 71892274 Common mntH manganese transport protein MntH BPEN_518 106 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 71892267 Common folC dihydrofolate synthase BPEN_510 216 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 71891846 Common rpoD RNA polymerase sigma-70 factor BPEN_057 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 71891849 Common gcp putative O-sialoglycoprotein endopeptidase BPEN_060 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 71892354 Common ilvA threonine dehydratase BPEN_610 200 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 71891890 Common nusA transcription elongation factor NusA BPEN_107 218 COG0195 NusA, Transcription elongation factor Transcription 71892344 Common yhgN putative eubacterial dITP- and XTP- hydrolyzing enzyme BPEN_595 157 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 71892397 Common pgi glucose-6-phosphate isomerase BPEN_656 188 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 71891830 Common yidZ putative transcriptional regulator with periplasmic binding protein domain (LysR family) BPEN_038 87 COG0583 LysR, Transcriptional regulator Transcription 71891916 Common imp organic solvent tolerance protein precursor BPEN_133 77 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 71892097 Common ybeY hypothetical protein BPEN_324 174 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 71891970 Common murB UDP-N-acetylenolpyruvoylglucosamine reductase BPEN_189 165 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 71891991 Common rplR 50S ribosomal protein L18 BPEN_214 207 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 71891936 Common coaE Dephospho-CoA kinase BPEN_153 201 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 71891817 Common ubiA 4-hydroxybenzoate octaprenyltransferase BPEN_025 168 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 71892021 Common yajR putative transport protein (MFS family) BPEN_247 165 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 71892172 Common purB adenylosuccinate lyase BPEN_405 228 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 71891827 Common pepA cytosol aminopeptidase BPEN_035 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 71891889 Nonpathogen secG preprotein translocase, membrane component BPEN_104 1 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 71892114 Common tolR TolR BPEN_346 20 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 71892228 Common yebA conserved protein with LysM domain BPEN_466 188 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 71892178 Common ycfH putative metallo-dependent hydrolase BPEN_411 237 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 71892361 Common metB cystathionine gamma-synthase BPEN_620 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 71892388 Common ubiD 3-octaprenyl-4-hydroxybenzoate decarboxylase BPEN_647 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 71891851 Common folB dihydroneopterin aldolase, also has dihydroneopterin triphosphate BPEN_062 58 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 71892215 Common minC MinC BPEN_453 102 COG0850 MinC, Septum formation inhibitor Cell division and chromosome partitioning 71892390 Common ubiE 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase BPEN_649 214 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 71891984 Common rpsQ 30S ribosomal subunit protein S17 BPEN_207 239 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 71892104 Common pgm phosphoglucomutase BPEN_335 191 COG0033 Pgm, Phosphoglucomutase Carbohydrate transport and metabolism 71892378 Common dfp 4'-phosphopantothenoylcysteine decarboxylase BPEN_637 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 71892316 Common ung uracil-DNA glycosylase BPEN_563 128 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 71891998 Common rpsD 30S ribosomal protein S4 BPEN_222 216 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 71891977 Common rplW 50S ribosomal subunit protein L23 BPEN_200 198 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 71892326 Common rpoB DNA-directed RNA polymerase subunit beta BPEN_577 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 71891909 Common carA carbamoyl phosphate synthase small subunit BPEN_126 234 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 71892355 Common ilvD dihydroxy-acid dehydratase BPEN_611 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 71892059 Common cdsA phosphatidate cytidylyltransferase BPEN_285 215 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 71891922 Common ftsL cell division protein BPEN_139 20 COG3116 FtsL, Cell division protein Cell division and chromosome partitioning 71891924 Common murE UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase BPEN_141 210 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 71892083 Common dnaX DNA polymerase III, tau and gamma subunits BPEN_309 247 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 71892012 Common secD preprotein translocase subunit SecD BPEN_238 208 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 71891825 Common valS valine tRNA synthetase BPEN_033 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 71891797 Common atpF ATP synthase, F0 sector, subunit b BPEN_004 139 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 71892111 Common sucC succinyl-CoA synthetase, beta chain BPEN_343 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 71892290 Common bcp thioredoxin-dependent thiol peroxidase BPEN_537 203 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 71892181 Common pabC 4-amino-4-deoxychorismate lyase BPEN_414 142 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 71892230 Common argS arginyl-tRNA synthetase BPEN_468 247 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 71892403 Common ybiS hypothetical protein BPEN_424 69 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 71892386 Common polA DNA polymerase I BPEN_645 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 71892095 Common lnt apolipoprotein N-acyltransferase BPEN_322 159 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 71891900 Common thrC threonine synthase BPEN_117 165 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 71891894 Common rpsO 30S ribosomal subunit protein S15 BPEN_111 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 71892208 Common cls cardiolipin synthetase BPEN_446 152 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 71892365 Common pfkA 6-phosphofructokinase BPEN_624 159 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 71891940 Common aceF branched-chain alpha-keto acid dehydrogenase subunit E2 BPEN_157 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 71892360 Common metF 5,10-methylenetetrahydrofolate reductase BPEN_619 138 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 71892126 Common lolB outer membrane lipoprotein precursor BPEN_358 20 COG3017 LolB, Outer membrane lipoprotein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 71892064 Common fabZ (3R)-hydroxymyristoyl-(acyl carrier protein) dehydratase BPEN_290 187 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 71891867 Common miaA delta(2)-isopentenylpyrophosphate tRNA-adenosine transferase BPEN_081 213 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 71892146 Common rnt ribonuclease T BPEN_379 50 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 71891983 Common rpmC 50S ribosomal subunit protein L29 BPEN_206 36 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 71891914 Common pdxA pyridoxine phosphate biosynthetic protein PdxJ-PdxA subunit, NAD-dependent dehydrogenase/carboxylase BPEN_131 159 COG1995 PdxA, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 71891952 Common cysC adenosine 5-phosphosulfate kinase BPEN_169 145 COG0529 CysC, Adenylylsulfate kinase and related kinases Inorganic ion transport and metabolism 71892350 Common hemD uroporphyrinogen-III synthase BPEN_602 54 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 71892282 Common cysW thiosulfate permease W protein (ABC superfamily, membrane) BPEN_529 210 COG4208 CysW, ABC-type sulfate transport system, permease component Inorganic ion transport and metabolism 71891837 Common yrbA putative transcriptional regulator (BolA family) BPEN_046 29 COG5007 COG5007, Predicted transcriptional regulator, BolA superfamily Transcription 71892256 Common nuoL NADH dehydrogenase I chain L, membrane subunit BPEN_499 210 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 71892265 Common nuoB NADH dehydrogenase subunit B BPEN_508 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 71891877 Common cysQ CysQ BPEN_091 181 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 71891840 Common yhcB hypothetical protein BPEN_049 15 COG3105 COG3105, Uncharacterized protein conserved in bacteria Function unknown 71891813 Common glyS glycine-tRNA synthetase, beta subunit BPEN_020 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 71892241 Common hisF imidazole glycerol phosphate synthase subunit HisF BPEN_483 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 71892376 Common rpmG 50S ribosomal subunit protein L33 BPEN_635 114 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 71892140 Common sufD cysteine desulfurase activator complex subunit SufD BPEN_372 162 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 71892017 Common pgpA phosphatidylglycerophosphatase A BPEN_243 95 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 71892158 Common rpsA 30S ribosomal protein S1 BPEN_391 221 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 71892206 Common yciC hypothetical protein BPEN_444 15 None None None 71892006 Common rnhA ribonuclease H BPEN_231 175 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 71891975 Common rplC 50S ribosomal subunit protein L3 BPEN_198 225 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 71892106 Common sdhD succinate dehydrogenase hydrophobic membrane anchor protein BPEN_338 52 COG2142 SdhD, Succinate dehydrogenase, hydrophobic anchor subunit Energy production and conversion 71891883 Common obgE GTPase ObgE BPEN_098 249 COG0536 Obg, Predicted GTPase General function prediction only 71892001 Common fmt methionyl-tRNA formyltransferase BPEN_225 217 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 71892319 Common smpA small membrane protein A BPEN_566 35 COG2913 SmpA, Small protein A (tmRNA-binding) Translation, ribosomal structure and biogenesis 71892151 Common fumC fumarate hydratase BPEN_384 215 COG0114 FumC, Fumarase Energy production and conversion 71892330 Common rplK 50S ribosomal subunit protein L11 BPEN_581 246 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 71892076 Common mreB rod shape-determining protein BPEN_302 233 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 71891986 Common rplX 50S ribosomal protein L24 BPEN_209 195 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 71892318 Common yfjB probable inorganic polyphosphate/ATP-NAD kinase BPEN_565 240 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 71891802 Common atpC ATP synthase, F1 sector, epsilon-subunit BPEN_009 163 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 71892346 Common corA Mg2+/Ni2+/Co2+ transport protein (Mg transport system I) (MIT family) BPEN_597 146 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 71892133 Common rplT 50S ribosomal protein L20 BPEN_365 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 71892339 Common rpe ribulose-phosphate 3-epimerase BPEN_590 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 71892224 Common cspC cold shock-like protein cspC BPEN_462 182 COG1278 CspC, Cold shock proteins Transcription 71891815 Common prlC oligopeptidase A BPEN_023 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 71892147 Common slyA transcriptional regulator SlyA BPEN_380 77 COG1846 MarR, Transcriptional regulators Transcription 71891832 Common znuC high-affinity Zn transport protein (ABC superfamily, atp_bind) BPEN_041 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 71892026 Common cyoA cytochrome o ubiquinol oxidase, subunit II BPEN_252 122 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 71892223 Common manZ mannose-specific PTS system protein IID BPEN_461 41 COG3716 ManZ, Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID Carbohydrate transport and metabolism 71891853 Common cca tRNA CCA-pyrophosphorylase BPEN_064 185 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 71892163 Common lolA LolA BPEN_396 49 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 71891912 Common apaH diadenosine tetraphosphatase BPEN_129 105 COG0639 ApaH, Diadenosine tetraphosphatase and related serine/threonine protein phosphatases Signal transduction mechanisms 71892363 Common fpr ferredoxin-NADP reductase BPEN_622 101 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 71892066 Common lpxB lipid-A-disaccharide synthase BPEN_292 139 COG0763 LpxB, Lipid A disaccharide synthetase Cell envelope biogenesis, outer membrane 71892284 Common cysP thiosulfate transport protein (ABC superfamily, peri_bind) BPEN_531 89 COG4150 CysP, ABC-type sulfate transport system, periplasmic component Inorganic ion transport and metabolism 71892128 Common hemK N5-glutamine methyltransferase BPEN_360 214 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 71892329 Common rplA 50S ribosomal subunit protein L1 BPEN_580 246 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 71891808 Common dnaN DNA polymerase III, beta-subunit BPEN_015 214 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 71891953 Common ygbQ cell division protein BPEN_170 60 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 71891836 Common yrbK possible exported protein BPEN_045 24 COG3117 COG3117, Uncharacterized protein conserved in bacteria Function unknown 71891996 Common rpsM 30S ribosomal protein S13 BPEN_220 247 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 71892047 Common lgt prolipoprotein diacylglyceryl transferase BPEN_273 206 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 71892236 Common hisG ATP phosphoribosyltransferase BPEN_477 208 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 71892211 Common xthA exonuclease III BPEN_449 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 71892396 Common yhhF putative methyltransferase with SAM-dependent methyltransferase domain BPEN_655 192 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 71892192 Common yccK putative sulfite reductase BPEN_430 53 COG2920 DsrC, Dissimilatory sulfite reductase (desulfoviridin), gamma subunit Inorganic ion transport and metabolism 71892251 Common nrdA ribonucleotide-diphosphate reductase subunit alpha BPEN_494 204 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 71892320 Common yfjG hypothetical protein BPEN_567 100 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 71892040 Common ubiH 2-octaprenyl-6-methoxyphenol hydroxylase BPEN_266 112 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 71892080 Common pmbA PmbA BPEN_306 157 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 71891972 Common coaA pantothenate kinase BPEN_191 70 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 71892402 Nonpathogen - hypothetical protein BPEN_336 1 None None None 71892297 Common ureA urease subunit gamma BPEN_544 96 COG0831 UreA, Urea amidohydrolase (urease) gamma subunit Amino acid transport and metabolism 71892022 Common cyoE protohaeme IX farnesyltransferase BPEN_248 169 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 71892119 Common ybhE 6-phosphogluconolactonase BPEN_351 48 COG2706 COG2706, 3-carboxymuconate cyclase Carbohydrate transport and metabolism 71892183 Common fabG 3-oxoacyl-[acyl-carrier protein] reductase BPEN_416 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 71891930 Common murC UDP-N-acetyl-muramate:alanine ligase BPEN_147 207 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 71892018 Common dxs 1-deoxy-D-xylulose-5-phosphate synthase BPEN_244 224 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 71891950 Common cysD sulfate adenylyltransferase subunit 2 BPEN_167 133 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 71891910 Common carB carbamoyl-phosphate synthase, large chain BPEN_127 236 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 71892352 Common trxA thioredoxin 1, redox factor BPEN_608 232 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 71892349 Common hemC porphobilinogen deaminase BPEN_601 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 71892051 Common dapD 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase BPEN_277 144 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 71892394 Common rpoH RNA polymerase factor sigma-32 BPEN_653 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 71891964 Common aroF phospho-2-dehydro-3-heoxyheptonate aldolase BPEN_183 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 71891875 Common rpsR 30S ribosomal protein S18 BPEN_089 213 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 71892110 Common sucB dihydrolipoamide succinyltransferase E2 component BPEN_342 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 71892303 Common hisS histidyl-tRNA synthetase BPEN_550 247 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 71892331 Common nusG transcription antitermination protein BPEN_582 215 COG0250 NusG, Transcription antiterminator Transcription 71892226 Common zwf glucose-6-phosphate 1-dehydrogenase BPEN_464 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 71892154 Common kdsB 3-deoxy-manno-octulosonate cytidylyltransferase BPEN_387 137 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 71892389 Common ubiB 2-octaprenylphenol hydroxylase of ubiquinone biosynthetic pathway BPEN_648 184 COG0661 AarF, Predicted unusual protein kinase General function prediction only 71892194 Common fabA 3-hydroxydecanoyl-(acyl carrier protein) dehydratase BPEN_432 82 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 71891963 Common rplS 50S ribosomal protein L19 BPEN_182 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 71892301 Common mqo malate:quinone oxidoreductase BPEN_548 57 COG0579 COG0579, Predicted dehydrogenase General function prediction only 71892024 Common cyoC cytochrome o ubiquinol oxidase, subunit III BPEN_250 156 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 71892030 Common mutY adenine DNA glycosylase BPEN_256 235 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 71892248 Common omp outer membrane protein BPEN_491 21 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 71892093 Common rlpB rare lipoprotein B precursor BPEN_320 20 COG2980 RlpB, Rare lipoprotein B Cell envelope biogenesis, outer membrane 71892174 Common lolD transport protein of outer membrane lipoproteins (ABC superfamily, atp_bind) BPEN_407 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 71892312 Common pdxJ pyridoxal phosphate biosynthetic protein PdxJ BPEN_559 139 COG0854 PdxJ, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 71892132 Common rpmI 50S ribosomal protein L35 BPEN_364 145 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 71892333 Common tuf elongation factor Tu BPEN_584 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 71891988 Common rpsN 30S ribosomal subunit protein S14 BPEN_211 181 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 71892366 Common cysE serine acetyltransferase BPEN_625 213 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 71892384 Common glnA glutamine synthetase BPEN_643 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 71892108 Common sdhB succinate dehydrogenase iron-sulfur subunit BPEN_340 201 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 71892373 Common rfaC ADP-heptose; LPS heptosyl transferase I BPEN_632 65 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 71892003 Common yrdC putative RNA-binding protein with unique protein fold, with YrdC/RibB domain BPEN_227 233 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 71891935 Common secA preprotein translocase subunit SecA BPEN_152 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 71891994 Common secY preprotein translocase, membrane component BPEN_218 216 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 71892070 Common tilS tRNA(Ile)-lysidine synthetase BPEN_296 182 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 71892200 Common trpE anthranilate synthase component I BPEN_438 221 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 71892243 Common gnd 6-phosphogluconate dehydrogenase BPEN_485 155 COG0362 Gnd, 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 71891897 Common holD DNA polymerase III, psi subunit BPEN_114 17 COG3050 HolD, DNA polymerase III, psi subunit DNA replication, recombination, and repair 71892300 Common guaB inosine-5'-monophosphate dehydrogenase BPEN_547 233 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 71892121 Common ybhL putative transport protein BPEN_353 126 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 71892270 Common pdxB erythronate-4-phosphate dehydrogenase BPEN_513 222 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 71892139 Common sufC putative transport protein associated with Fe-S cluster assembly (ABC superfamily, atp_bind) BPEN_371 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 71892262 Common nuoF NADH dehydrogenase I chain F BPEN_505 159 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 71892037 Common rpiA ribose-5-phosphate isomerase A BPEN_263 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 71892291 Common upp uracil phosphoribosyltransferase BPEN_538 164 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 71892207 Common tonB energy transducer; uptake of iron, cyanocobalimin; sensitivity to phages, colicins BPEN_445 24 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 71892358 Common ilvG acetolactate synthase 2 catalytic subunit BPEN_614 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 71891869 Common hflX HflX BPEN_083 224 COG2262 HflX, GTPases General function prediction only 71892169 Common emtA membrane-bound lytic murein transglycosylase E BPEN_402 85 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 71891944 Common pyrG CTP synthetase BPEN_161 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 71892298 Common ureD putative urease accessory protein D BPEN_545 55 COG0829 UreH, Urease accessory protein UreH Posttranslational modification, protein turnover, chaperones 71892015 Common ribH 6,7-dimethyl-8-ribityllumazine synthase BPEN_241 224 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 71891884 Common greA transcription elongation factor BPEN_099 204 COG0782 GreA, Transcription elongation factor Transcription 71891855 Common ribB 3,4-dihydroxy-2-butanone 4-phosphate synthase BPEN_067 228 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 71891941 Common aceE pyruvate dehydrogenase subunit E1 BPEN_158 141 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 71891843 Common yraP putative periplasmic protein BPEN_052 61 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 71891838 Common murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase BPEN_047 209 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 71892253 Common yfaE conserved hypothetical protein with 2Fe-2S ferredoxin-like domain BPEN_496 38 COG0633 Fdx, Ferredoxin Energy production and conversion 71891823 Common yjgF putative translation initiation inhibitor BPEN_031 177 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 71892091 Common ybeB hypothetical protein BPEN_318 201 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 71892029 Common yggX hypothetical protein BPEN_255 71 COG2924 COG2924, Uncharacterized protein conserved in bacteria Function unknown 71892072 Common gmhB D,D-heptose 1,7-bisphosphate phosphatase BPEN_298 123 COG0241 HisB, Histidinol phosphatase and related phosphatases Amino acid transport and metabolism 71892100 Common nagB glucosamine-6-phosphate deaminase BPEN_331 84 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 71892359 Common murI glutamate racemase BPEN_618 190 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 71891888 Common mrsA PGM/PMM-family protein BPEN_103 239 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 71892334 Common fusA elongation factor G BPEN_585 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 71892141 Common sufS selenocysteine lyase BPEN_373 238 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 71892286 Common tktA transketolase BPEN_533 222 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 71892098 Common phoL putative ATP-binding protein in pho regulon BPEN_325 198 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 71892068 Common dnaE DNA polymerase III, alpha chain BPEN_294 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 71891959 Common ffh 4.5S-RNP protein BPEN_178 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 71891906 Common lspA prolipoprotein signal peptidase BPEN_123 185 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 71891966 Common pheA chorismate mutase P BPEN_185 203 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 71892053 Common rpsB 30S ribosomal protein S2 BPEN_279 223 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 71892008 Common gmhA phosphoheptose isomerase BPEN_233 121 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 71891794 Common gidA tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA BPEN_001 192 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 71892276 Common gltX glutamate tRNA synthetase, catalytic subunit BPEN_521 247 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 71892398 Common metA homoserine O-succinyltransferase BPEN_657 64 COG1897 MetA, Homoserine trans-succinylase Amino acid transport and metabolism 71892295 Common ureC urease subunit alpha BPEN_542 96 COG0804 UreC, Urea amidohydrolase (urease) alpha subunit Amino acid transport and metabolism 71892189 Common rne ribonuclease E BPEN_422 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 71891928 Common ftsW cell division protein BPEN_145 206 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 71892258 Common nuoJ NADH dehydrogenase I chain J BPEN_501 122 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 71891811 Common - probable transmembrane protein BPEN_018 20 COG0628 PerM, Predicted permease General function prediction only 71892400 Common ubiF 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol oxygenase BPEN_326 118 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 71892216 Common minD MinD BPEN_454 141 COG2894 MinD, Septum formation inhibitor-activating ATPase Cell division and chromosome partitioning 71892089 Common mrdB rod shape-determining protein BPEN_316 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 71892185 Common fabH 3-oxoacyl-(acyl carrier protein) synthase III BPEN_418 224 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 71891917 Common leuD 3-isopropylmalate dehydratase subunit 1 BPEN_134 206 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 71891860 Common groEL chaperonin GroEL BPEN_073 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 71892340 Common aroB 3-dehydroquinate synthase BPEN_591 205 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 71892201 Common trpG anthranilate synthase component II: glutamine amidotransferase BPEN_439 238 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 71892377 Common rpmB 50S ribosomal protein L28 BPEN_636 133 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 71892061 Common yaeT outer membrane protein precursor BPEN_287 150 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 71892199 Common ribA GTP cyclohydrolase II BPEN_437 177 COG0807 RibA, GTP cyclohydrolase II Coenzyme metabolism 71892117 Common pal Pal BPEN_349 147 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 71892382 Common gmk guanylate kinase BPEN_641 212 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 71891899 Common thrB homoserine kinase BPEN_116 128 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 71892167 Common oprC OprC BPEN_400 56 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 71892314 Common lepB signal peptidase I BPEN_561 191 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 71892234 Common yeeX hypothetical protein BPEN_475 22 COG2926 COG2926, Uncharacterized protein conserved in bacteria Function unknown 71892136 Common lplA lipoate-protein ligase A BPEN_368 71 COG0095 LplA, Lipoate-protein ligase A Coenzyme metabolism 71892371 Common hldD ADP-L-Glycero-D-mannoheptose-6-epimerase BPEN_630 194 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 71892214 Common dsbB disulfide bond formation protein B BPEN_452 35 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 71891933 Common ftsZ cell division protein FtsZ BPEN_150 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 71892130 Common thrS threonyl-tRNA synthetase BPEN_362 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 71891921 Common mraW S-adenosyl-dependent methyl transferase BPEN_138 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 71892042 Common ygfZ putative aminomethyltransferase BPEN_268 77 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 71892315 Common lepA GTP-binding protein LepA BPEN_562 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 71892005 Common gloB probable hydroxyacylglutathione hydrolase BPEN_230 188 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 71892322 Common emrE auxillary multidrug transport protein (SMR family) BPEN_570 132 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 71892342 Common gntY membrane-bound protein in GNT I transport system BPEN_593 64 COG0694 COG0694, Thioredoxin-like proteins and domains Posttranslational modification, protein turnover, chaperones 71891992 Common rpsE 30S ribosomal subunit protein S5 BPEN_215 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 71892156 Common lpxK tetraacyldisaccharide 4'-kinase BPEN_389 126 COG1663 LpxK, Tetraacyldisaccharide-1-P 4'-kinase Cell envelope biogenesis, outer membrane 71892220 Common yoaE putative transmembrane protein BPEN_458 213 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 71891919 Common leuB 3-isopropylmalate dehydrogenase BPEN_136 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 71891807 Common rmpH 50S ribosomal subunit protein L34 BPEN_014 190 COG0230 RpmH, Ribosomal protein L34 Translation, ribosomal structure and biogenesis 71892137 Common sufA Fe-S cluster assembly protein BPEN_369 161 COG0316 IscA, Uncharacterized conserved protein Function unknown 71892307 Common nifS putative L-cysteine desulfurase BPEN_554 239 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 71892260 Common nuoH NADH dehydrogenase subunit H BPEN_503 186 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 71892116 Common tolB TolB BPEN_348 153 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 71892187 Common rpmF 50S ribosomal subunit protein L32 BPEN_420 82 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 71892049 Common recD exonuclease V, alpha chain BPEN_275 123 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 71892176 Common ycfM putative fibronectin-binding protein BPEN_409 13 COG3417 FlgN, Collagen-binding surface adhesin SpaP (antigen I/II family) General function prediction only 71891873 Common rlmB probable tRNA/rRNA methyltransferase BPEN_087 215 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 71891844 Common yraL hypothetical protein BPEN_053 209 COG0313 COG0313, Predicted methyltransferases General function prediction only 71892102 Common fldA flavodoxin FldA BPEN_333 72 COG0716 FldA, Flavodoxins Energy production and conversion 71891857 Common metC beta-cystathionase BPEN_069 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 71891886 Common hflB FtsH BPEN_101 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 71891819 Common dnaB replicative DNA helicase BPEN_027 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 71892279 Common ptsH PTS family Hpr protein, phosphohistidinoprotein-hexose phosphotransferase BPEN_526 129 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 71891979 Common rpsS 30S ribosomal protein S19 BPEN_202 245 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 71892035 Common pgk phosphoglycerate kinase BPEN_261 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism