Tropheryma whipplei TW08/27, complete genome NC_004551 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 28572401 Common - ATP-dependent DNA helicase subunit TW242 22 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 28572866 Common lysC aspartokinase TW725 234 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 28572950 Common - conserved integral membrane protein (possible virulence factor) TW809 188 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 28572773 Common - hypothetical protein TW627 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 28572300 Common manB phosphomannomutase/phosphoglucomutase TW137 242 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 28572719 Common smpB SsrA-binding protein TW571 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 28572936 Common - sodium/proton antiporter TW795 106 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 28572415 Common gpsA glycerol-3-phosphate dehydrogenase TW256 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 28572202 Common - integral membrane protein TW027 12 COG2246 COG2246, Predicted membrane protein Function unknown 28572279 Common - WiSP family protein TW113 18 None None None 28572556 Common carA carbamoyl phosphate synthase small subunit TW403 235 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 28572389 Common rpmJ 50S ribosomal protein L36 TW229 133 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 28572755 Common infC translation initiation factor IF-3 TW608 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 28572747 Pathogen - hypothetical protein TW599 1 None None None 28572468 Common - hypothetical protein TW313 193 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 28572824 Common - hypothetical protein TW683 16 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 28572492 Common atpB F0F1 ATP synthase subunit A TW338 171 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 28572211 Common - ABC transport ATP-binding subunit TW038 249 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 28572948 Common - glycosyltransferase TW807 205 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 28572203 Common purK phosphoribosylaminoimidazole carboxylase ATPase subunit PurK TW028 193 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 28572943 Common - chorismate mutase TW802 28 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 28572811 Common sgaU L-xylulose 5-phosphate 3-epimerase TW670 25 COG3623 SgaU, Putative L-xylulose-5-phosphate 3-epimerase Carbohydrate transport and metabolism 28572566 Common - sugar-1-phosphate nucleotidyltransferase TW414 161 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 28572544 Common - hypothetical protein TW391 39 None None None 28572671 Common qcrA ubiquinol-cytochrome C reductase iron-sulfur subunit TW522 42 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 28572645 Common relA GTP pyrophosphokinase TW496 206 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 28572624 Common uvrC excinuclease ABC subunit C TW475 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 28572524 Common pepN aminopeptidase N TW371 165 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 28572617 Common - hypothetical protein TW468 10 None None None 28572428 Common gnd 6-phosphogluconate dehydrogenase TW272 176 COG0362 Gnd, 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 28572250 Common rpoC DNA-directed RNA polymerase subunit beta' TW082 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 28572396 Common - hypothetical protein TW236 16 COG4420 COG4420, Predicted membrane protein Function unknown 28572317 Common rpsI 30S ribosomal protein S9 TW154 236 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 28572281 Common rpsR 30S ribosomal protein S18 TW115 24 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 28572678 Common - hypothetical protein TW529 171 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 28572599 Common - hypothetical protein TW449 13 None None None 28572913 Pathogen - WiSP family protein TW772 1 None None None 28572586 Common - hypothetical protein TW435 165 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 28572581 Common tal transaldolase TW430 106 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 28572840 Common greA transcription elongation factor GreA TW699 190 COG0782 GreA, Transcription elongation factor Transcription 28572549 Common aroE shikimate 5-dehydrogenase TW396 127 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 28572292 Common - integral membrane protein TW129 27 COG3336 COG3336, Predicted membrane protein Function unknown 28572497 Common atpG ATP synthase gamma chain TW343 207 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 28572596 Common adh alcohol dehydrogenase TW445 208 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 28572257 Common guaA bifunctional GMP synthase/glutamine amidotransferase protein TW089 239 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 28572227 Common - cold shock protein B TW057 47 COG1278 CspC, Cold shock proteins Transcription 28572590 Common - hypothetical protein TW439 26 COG3346 COG3346, Uncharacterized conserved protein Function unknown 28572486 Common rho transcription termination factor Rho TW332 197 COG1158 Rho, Transcription termination factor Transcription 28572729 Common - hypothetical protein TW581 55 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion 28572307 Common gcvP glycine dehydrogenase TW144 172 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 28572376 Common rpsQ 30S ribosomal protein S17 TW216 223 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 28572850 Common ribA GTP cyclohydrolase II TW709 183 COG0807 RibA, GTP cyclohydrolase II Coenzyme metabolism 28572184 Common - integral membrane protein TW009 170 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 28572274 Common - DNA recombinase TW108 228 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 28572934 Common eno enolase TW793 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 28572775 Common pgsA CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase TW629 205 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 28572900 Common hspR heat shock regulator protein HspR TW759 47 COG0789 SoxR, Predicted transcriptional regulators Transcription 28572451 Pathogen - hypothetical protein TW295 1 None None None 28572382 Common rplR 50S ribosomal protein L18 TW222 215 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 28572832 Common - conserved large hypothetical protein TW691 48 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 28572565 Common rpe D-ribulose-5-phosphate 3-epimerase TW413 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 28572341 Common ung uracil-DNA glycosylase TW179 130 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 28572652 Common ruvC crossover junction endodeoxyribonuclease RuvC TW503 189 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 28572634 Common dgt deoxyguanosinetriphosphate triphosphohydrolase-like protein TW485 159 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 28572915 Pathogen - WiSP family protein TW774 1 None None None 28572550 Common aroC chorismate synthase TW397 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 28572335 Common ftsH FtsH-like cell division protein TW173 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 28572717 Common ksgA dimethyladenosine transferase TW569 233 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 28572364 Common - branched chain amino acid ABC transporter ATP-binding subunit TW204 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 28572684 Common - hypothetical protein TW535 17 COG0789 SoxR, Predicted transcriptional regulators Transcription 28572454 Common - hypothetical protein TW298 6 None None None 28572417 Common - conserved hypothetical lipoprotein TW258 8 None None None 28572673 Common ctaE cytochrome c oxidase subunit III TW524 159 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 28572531 Common - hypothetical protein TW378 12 COG1985 RibD, Pyrimidine reductase, riboflavin biosynthesis Coenzyme metabolism 28572249 Common rpoB DNA-directed RNA polymerase subunit beta TW081 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 28572298 Common - integral membrane protein TW135 26 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 28572708 Common - conserved integral membrane protein (BioY-family) TW560 100 COG1268 BioY, Uncharacterized conserved protein General function prediction only 28572622 Common sodA superoxide dismutase TW473 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 28572730 Common - hypothetical protein TW582 9 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 28572689 Common murC UDP-N-acetylmuramate--alanine ligase TW541 209 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 28572847 Common ribD riboflavin biosynthesis protein RibD TW706 223 COG1985 RibD, Pyrimidine reductase, riboflavin biosynthesis Coenzyme metabolism 28572803 Common - secreted protein TW662 119 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 161501892 Common rplF 50S ribosomal protein L6 TW221 241 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 28572268 Common - conserved hypothetical protein (ATP-binding) TW101 38 COG3593 COG3593, Predicted ATP-dependent endonuclease of the OLD family DNA replication, recombination, and repair 28572328 Common - serine/threonine protein kinase TW165 20 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 28572226 Common - two component system response regulator TW055 220 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 28572501 Common pnp polynucleotide phosphorylase/polyadenylase TW347 234 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 28572791 Common pdhD mycothione/glutathione reductase TW646 236 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 28572727 Common - hypothetical protein TW579 6 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 28572784 Common - hypothetical protein TW639 236 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 28572606 Common cysS2 cysteinyl-tRNA synthetase TW456 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 28572261 Common purH bifunctional purine biosynthesis protein PurH TW094 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 28572449 Common rpmA 50S ribosomal protein L27 TW293 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 28572217 Pathogen - hypothetical protein TW044 1 None None None 28572786 Common - nicotinate phosphoribosyltransferase TW641 109 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 28572642 Common - hypothetical protein TW493 5 COG4762 COG4762, Uncharacterized protein conserved in bacteria Function unknown 28572502 Common - cation efflux protein TW348 175 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 28572703 Common - eukaryotic-type serine/threonine protein kinase TW555 160 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 28572348 Common - integral membrane protein TW188 9 COG4987 CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 28572771 Pathogen - WiSP family protein TW625 1 None None None 28572864 Common - secreted protein TW723 52 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 28572534 Common - secreted protein TW381 13 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 28572371 Common rpsS 30s ribosomal protein s19 TW211 244 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 28572872 Common rplK 50S ribosomal protein L11 TW731 246 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 28572839 Pathogen - hypothetical protein TW698 1 None None None 28572893 Common dnaB replicative DNA helicase TW752 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 28572199 Pathogen - integral membrane protein TW024 1 None None None 28572479 Common - hypothetical protein TW324 7 None None None 28572489 Common - hypothetical protein TW335 233 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 28572233 Common - ubiquinone/menaquinone methyltransferase TW063 197 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 28572210 Common - glycosyl transferase TW037 66 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 28572408 Common - cell division protein TW249 19 COG3599 DivIVA, Cell division initiation protein Cell division and chromosome partitioning 28572423 Common - conserved hypothetical protein (possible murein ligase) TW264 52 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 161501889 Common fabH 3-oxoacyl-(acyl carrier protein) synthase III TW517 212 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 28572594 Common - sugar ABC transporter substrate-binding lipoprotein subunit TW443 90 COG4213 XylF, ABC-type xylose transport system, periplasmic component Carbohydrate transport and metabolism 28572480 Common - secreted protein TW325 13 None None None 28572305 Common - regulator TW142 23 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 28572870 Common rplJ 50S ribosomal protein L10 TW729 157 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 28572615 Common ppa1 inorganic pyrophosphatase TW465 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 28572957 Common - hypothetical protein TW816 177 COG0759 COG0759, Uncharacterized conserved protein Function unknown 28572835 Common fusA elongation factor G TW694 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 28572475 Common pyrH uridylate kinase TW320 234 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 28572693 Common murE UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diami nopimelate ligase TW545 209 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 28572750 Common tyrS tyrosyl-tRNA synthetase TW603 216 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 28572207 Common - dehydratase TW033 235 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 28572426 Common alr2 alanine racemase II TW267 123 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 28572904 Common - conserved hypothetical protein (deaminase) TW763 215 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 28572186 Common - glutamine amidotransferase TW011 238 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 28572394 Common truA tRNA pseudouridine synthase A TW234 231 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 28572690 Common murG N-acetylglucosaminyl transferase TW542 207 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 28572554 Common efp elongation factor P TW401 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 28572205 Pathogen - integral membrane protein TW030 1 None None None 28572310 Common - ABC transporter integral membrane subunit TW147 36 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 28572820 Common - hypothetical protein TW679 44 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 28572499 Common atpC ATP synthase epsilon chain TW345 16 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 28572737 Common mfd transcription-repair coupling factor TW589 217 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 28572222 Pathogen - integral membrane protein TW051 1 None None None 28572508 Common ligA DNA ligase TW354 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 28572519 Pathogen - hypothetical protein TW366 3 None None None 28572601 Common tatC sec-independent protein translocase protein TatC TW451 197 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 28572932 Common - hypothetical protein TW791 27 COG1507 COG1507, Uncharacterized conserved protein Function unknown 28572826 Common - ABC-transporter periplasmic solute-binding subunit TW685 168 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 28572244 Common - phospholipase TW074 151 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 28572434 Common - hypothetical protein TW278 19 None None None 28572229 Common - sporulation/chromosome partition protein TW059 221 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 28572465 Common sipS signal peptidase I TW309 171 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 28572542 Common - hypothetical protein TW389 19 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 28572330 Common - hypothetical protein TW167 170 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 28572360 Common - ABC transporter branched chain amino acid binding protein TW200 112 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 28572284 Common hemH phosphoribosylaminoimidazole-succinocarboxamide synthase TW119 165 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 28572720 Common ftsX cell division protein FtsX TW572 95 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 28572765 Pathogen - hypothetical protein TW619 1 None None None 28572608 Common rpmE2 50S ribosomal protein L31 type B TW458 132 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 28572944 Common purL phosphoribosylformylglycinamidine synthase II TW803 234 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 28572620 Common pgk phosphoglycerate kinase TW471 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 28572643 Common lepA GTP-binding protein LepA TW494 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 28572679 Common - integral membrane protein TW530 16 None None None 28572538 Common leuS leucyl-tRNA synthetase TW385 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 28572585 Common - hypothetical protein TW434 186 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 28572319 Common coaA pantothenate kinase TW156 81 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 28572880 Common purD phosphoribosylamine--glycine ligase TW739 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 28572757 Common - hypothetical protein TW611 4 None None None 28572842 Common nrdF ribonucleotide-diphosphate reductase subunit beta TW701 158 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 28572704 Common aroH phospho-2-dehydro-3-deoxyheptonate aldolase TW556 73 COG3200 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 28572393 Common rplQ 50S ribosomal protein L17 TW233 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 28572921 Common - secreted protein TW780 4 None None None 28572572 Pathogen - hypothetical protein TW420 1 None None None 28572613 Common - prolipoprotein diacylglyceryl transferase TW463 158 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 28572629 Common polA DNA polymerase I TW480 216 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 28572928 Common - penicillin-binding protein TW787 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 28572655 Common - pyridoxine biosynthesis protein TW506 87 COG0214 SNZ1, Pyridoxine biosynthesis enzyme Coenzyme metabolism 28572323 Common - hypothetical protein TW160 58 COG1814 COG1814, Uncharacterized membrane protein Function unknown 28572353 Pathogen - possible integral membrane protein TW193 1 None None None 28572845 Common - exodeoxyribonuclease TW704 192 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 28572793 Common parA2 chromosome partitioning protein TW648 206 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 28572220 Pathogen - secreted protein TW048 1 None None None 28572197 Pathogen - hypothetical protein TW022 1 None None None 28572419 Common acoL dihydrolipoamide dehydrogenase TW260 248 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 28572246 Common menD menaquinone biosynthesis protein MenD TW078 81 COG1165 MenD, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Coenzyme metabolism 28572362 Common - ABC transporter branched chain amino acid transport permease TW202 148 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 28572889 Common - hypothetical protein TW748 29 COG3253 COG3253, Uncharacterized conserved protein Function unknown 28572522 Common - putative ABC transporter ATP-binding protein TW369 248 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 28572715 Common ilvB acetolactate synthase 1 catalytic subunit TW567 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 28572384 Common rplO 50S ribosomal protein L15 TW224 166 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 28572782 Pathogen - hypothetical protein TW637 1 None None None 28572406 Common ftsZ cell division protein FtsZ TW247 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 28572374 Common rplP 50S ribosomal protein L16 TW214 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 28572346 Pathogen - integral membrane protein TW186 1 None None None 28572852 Common pncA pyrazinamidase/nicotinamidase TW711 68 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 28572632 Common - NLP/P60-family protein TW483 141 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 28572442 Common valS valyl-tRNA synthetase TW286 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 28572467 Common - hypothetical protein TW312 64 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 28572902 Common grpE heat shock protein GrpE TW761 132 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 28572337 Common folP dihydropteroate synthase TW175 220 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 28572639 Common - hypothetical protein TW490 199 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 28572863 Common - penicillin-binding protein/transpeptidase TW722 201 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 28572855 Common - nucleotide kinase TW714 233 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 28572926 Common - secreted protein TW785 42 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 28572744 Pathogen - hypothetical protein TW596 2 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 28572288 Common rpmB 50S ribosomal protein L28 TW125 145 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 28572251 Common - hydrolase TW083 28 COG0400 COG0400, Predicted esterase General function prediction only 28572215 Common - glycosyl transferase TW042 88 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 28572686 Pathogen - integral membrane protein TW537 2 None None None 28572358 Common rpmF 50S ribosomal protein L32 TW198 9 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 28572191 Common dkgA 2,5-diketo-D-gluconic acid reductase A TW016 146 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 28572431 Common - hypothetical protein TW275 19 None None None 28572640 Common - hypothetical protein TW491 18 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 28572563 Common - primosome assembly protein PriA TW410 206 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 28572477 Common - integral membrane phospholipid biosynthetic nucleotidyltransferase TW322 215 COG4589 COG4589, Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase General function prediction only 28572745 Pathogen - integral membrane protein TW597 1 None None None 28572691 Common ftsW cell division protein FtsW TW543 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 28572265 Common - metalloprotease TW098 213 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 28572635 Common uppS2 undecaprenyl pyrophosphate synthetase TW486 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 28572582 Common tkt transketolase TW431 221 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 28572752 Common pheS phenylalanyl-tRNA synthetase subunit alpha TW605 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 28572658 Common glnA glutamine synthetase TW509 226 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 28572860 Common - integral membrane protein TW719 12 None None None 28572792 Common pyc pyruvate carboxylase TW647 239 COG1038 PycA, Pyruvate carboxylase Energy production and conversion 28572670 Common qcrB ubiquinol-cytochrome C reductase cytochrome B subunit TW521 149 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 28572520 Common ssb2 single-strand DNA binding protein TW367 38 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 28572289 Common rpmG 50S ribosomal protein L33 TW126 128 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 28572822 Common - integral membrane protein TW681 19 COG4243 COG4243, Predicted membrane protein Function unknown 28572343 Pathogen - secreted protein TW181 1 None None None 28572482 Pathogen - integral membrane protein TW328 1 None None None 28572275 Common - NUDIX hydrolase TW109 133 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 28572527 Common nei endonuclease VIII TW374 143 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 161501890 Common recO DNA repair protein RecO TW487 65 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 28572223 Pathogen - secreted protein TW052 1 None None None 28572493 Common atpE ATP synthase C chain TW339 7 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 28572879 Common purM phosphoribosylaminoimidazole synthetase TW738 231 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 28572829 Pathogen - WiSP family protein TW688 1 None None None 28572767 Pathogen - proline/alanine-rich repetetive membrane anchored protein TW621 1 COG5373 COG5373, Predicted membrane protein Function unknown 28572270 Pathogen - integral membrane protein TW104 1 None None None 28572887 Common hemC porphobilinogen deaminase TW746 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 28572933 Pathogen - secreted protein TW792 2 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 28572760 Common infB translation initiation factor IF-2 TW614 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 28572897 Common xthA1 exodeoxyribonuclease III TW756 194 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 28572209 Common - nucleotidyl transferase TW036 233 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 28572759 Common rbfA ribosome-binding factor A TW613 100 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 28572876 Common - hypothetical protein TW735 42 COG2030 MaoC, Acyl dehydratase Lipid metabolism 28572552 Common aroB 3-dehydroquinate synthase TW399 205 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 28572559 Common gmk guanylate kinase TW406 213 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 28572576 Common - rRNA methyltransferase TW424 209 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 28572176 Common dnaA chromosomal replication initiator protein DnaA TW001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 28572304 Common - membrane/secreted protein TW141 5 None None None 28572909 Common - lipoprotein TW768 122 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 28572548 Common - conserved hypothetical protein (possibly secreted) TW395 185 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 28572954 Common - metal cation-transporting ATPase TW813 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 28572448 Common rplU 50S ribosomal protein L21 TW292 130 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 28572242 Common lysK lysyl-tRNA synthetase TW072 77 COG1384 LysS, Lysyl-tRNA synthetase (class I) Translation, ribosomal structure and biogenesis 28572815 Pathogen - integral membrane protein TW674 1 None None None 28572801 Common gcvT aminomethyltransferase gcvT TW659 179 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 28572796 Common gabT 4-aminobutyrate aminotransferase TW652 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 28572463 Common trmD tRNA (guanine-N1)-methyltransferase TW307 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 28572628 Common rpsA 30S ribosomal protein S1 TW479 215 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 28572946 Common purQ phosphoribosylformylglycinamidine synthase I TW805 227 COG0047 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain Nucleotide transport and metabolism 28572435 Common - integral membrane protein TW279 15 None None None 28572780 Pathogen - hypothetical protein TW634 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 28572410 Common - pseudouridine synthase TW251 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 28572664 Common aceE pyruvate dehydrogenase subunit E1 TW515 158 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 28572285 Common menB naphthoate synthase TW120 176 COG0447 MenB, Dihydroxynaphthoic acid synthase Coenzyme metabolism 28572512 Common - hypothetical protein TW358 6 None None None 28572668 Common fabF 3-oxoacyl-[acyl-carrier-protein] synthase II TW519 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 28572356 Common coaD phosphopantetheine adenylyltransferase TW196 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 28572779 Common thyX FAD-dependent thymidylate synthase TW633 62 COG1351 THY1, Predicted alternative thymidylate synthase Nucleotide transport and metabolism 28572361 Common - ABC transporter branched chain amino acid transport permease TW201 133 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 28572560 Common rpoZ DNA-directed RNA polymerase subunit omega TW407 19 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 28572698 Common mraW S-adenosyl-methyltransferase TW550 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 28572742 Common - ABC transporter ATP-binding protein TW594 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 28572470 Common - DNA recombinase TW315 226 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 28572236 Common - iron-siderophore binding lipoprotein TW066 40 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 28572214 Common - integral membrane protein TW041 9 COG2456 COG2456, Uncharacterized conserved protein Function unknown 28572688 Common ftsQ cell division protein FtsQ TW540 26 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 28572537 Common trpE anthranilate synthase component I TW384 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 28572579 Common zwf glucose-6-phosphate 1-dehydrogenase TW428 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 28572387 Common - 4-amino-4-deoxychorismate lyase TW227 166 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 28572553 Common aroQ 3-dehydroquinate dehydratase TW400 169 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 28572905 Common proC pyrroline-5-carboxylate reductase TW764 189 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 28572421 Common glyQS glycyl-tRNA synthetase TW262 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 28572366 Common rpsJ 30S ribosomal protein S10 TW206 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 28572637 Common era GTP-binding protein Era TW488 222 COG1159 Era, GTPase General function prediction only 28572808 Common - integral membrane sugar transport protein TW667 79 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 28572626 Common uvrB excinuclease ABC subunit B TW477 231 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 28572923 Common - hydrolase TW782 166 COG0546 Gph, Predicted phosphatases General function prediction only 28572464 Common rplS 50S ribosomal protein L19 TW308 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 28572413 Common murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase TW254 210 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 28572653 Common - hypothetical protein TW504 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 28572710 Common - oxidoreductase TW562 27 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 28572243 Common panC pantoate--beta-alanine ligase TW073 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 28572313 Common - ABC transporter system integral membrane subunit TW150 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 28572570 Common - phosphate ABC transporter ATP-binding protein TW418 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 28572253 Common guaB1 inosine-5'-monophosphate dehydrogenase TW085 242 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 28572351 Pathogen - secreted protein TW191 1 None None None 28572630 Common - two-component system response regulator TW481 219 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 28572345 Pathogen - peptidase TW184 1 None None None 28572325 Common - ABC transporter (ATP-binding and integral membrane) TW162 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 28572857 Pathogen - hypothetical protein TW716 2 None None None 28572409 Common lspA lipoprotein signal peptidase TW250 49 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 28572277 Common recN DNA repair protein RecN TW111 203 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 28572240 Common - iron-siderophore uptake system integral membrane component TW070 192 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 28572885 Common hemB delta-aminolevulinic acid dehydratase TW744 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 28572495 Common atpH ATP synthase delta chain TW341 19 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 28572225 Common - two component system sensor kinase TW054 217 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 28572372 Common rplV 50S ribosomal protein L22 TW212 190 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 28572438 Pathogen - integral membrane protein TW282 1 None None None 28572315 Pathogen - hypothetical protein TW152 1 None None None 28572461 Common - hypothetical protein TW305 23 COG1837 COG1837, Predicted RNA-binding protein (contains KH domain) General function prediction only 28572931 Common - NADH dehydrogenase TW790 146 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 28572911 Common - integral membrane protein TW770 18 COG1333 ResB, ResB protein required for cytochrome c biosynthesis Posttranslational modification, protein turnover, chaperones 28572633 Common dnaG DNA primase TW484 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 28572588 Common - ABC transporter ATP-binding subunit TW437 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 28572485 Common thrB homoserine kinase TW331 93 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 28572914 Common - hypothetical protein TW773 5 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 28572604 Common - hypothetical protein TW454 50 COG2519 GCD14, tRNA(1-methyladenosine) methyltransferase and related methyltransferases Translation, ribosomal structure and biogenesis 28572661 Common - hypothetical protein TW512 20 COG1579 COG1579, Zn-ribbon protein, possibly nucleic acid-binding General function prediction only 28572709 Pathogen - WiSP family protein TW561 1 None None None 28572593 Common - sugar ABC transporter permease subunit TW442 106 COG4214 XylH, ABC-type xylose transport system, permease component Carbohydrate transport and metabolism 28572700 Pathogen - WiSP family protein TW552 1 None None None 28572443 Common ileS isoleucyl-tRNA synthetase TW287 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 28572724 Common pyrB aspartate carbamoyltransferase TW576 239 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 28572271 Pathogen - integral membrane protein TW105 1 None None None 28572938 Common pdhC branched-chain alpha-keto acid dehydrogenase subunit E2 TW797 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 28572676 Common ctaC cytochrome c oxidase subunit II TW527 144 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 28572569 Common pstA phosphate ABC transporter permease TW417 229 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 28572412 Common - conserved integral membrane protein. TW253 89 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 28572647 Common secF preprotein translocase subunit SecF TW498 214 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 161501887 Common ribE riboflavin synthase subunit alpha TW707 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 28572490 Common - glycosyl transferase TW336 211 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 28572813 Common - hypothetical protein TW672 33 COG1735 Php, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 28572309 Common - ABC transporter substrate-binding protein TW146 138 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 28572530 Common - hypothetical protein TW377 18 None None None 28572611 Common - integral membrane protein TW461 11 None None None 28572949 Common - hypothetical protein TW808 25 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 28572869 Common rplL 50S ribosomal protein L7/L12 TW728 210 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 28572391 Common rpsK 30S ribosomal protein S11 TW231 247 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 28572398 Common - Xaa-Pro aminopeptidase TW238 209 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 28572874 Common aspC aspartate aminotransferase TW733 240 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 28572557 Common carB carbamoyl-phosphate synthase large chain TW404 234 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 28572302 Common secA preprotein translocase subunit SecA TW139 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 28572952 Common parB chromosome partitioning protein ParB TW811 185 COG1475 Spo0J, Predicted transcriptional regulators Transcription 28572198 Pathogen - integral membrane protein TW023 1 None None None 28572546 Common alaS alanyl-tRNA synthetase TW393 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 28572958 Pathogen rnpA ribonuclease P protein component TW817 1 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 28572761 Common nusA transcription elongation factor NusA TW615 220 COG0195 NusA, Transcription elongation factor Transcription 28572178 Common recF DNA replication and repair protein recF TW003 171 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 28572733 Common prsA ribose-phosphate pyrophosphokinase TW585 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 28572706 Common glk glucokinase TW558 164 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 28572354 Common aroA 3-phosphoshikimate 1-carboxyvinyltransferase TW194 230 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 28572891 Common hemA glutamyl-tRNA reductase TW750 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 28572777 Common - FtsK/SpoIIIE homologue TW631 198 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 28572749 Pathogen - hypothetical protein TW602 1 None None None 28572472 Common - hypothetical protein TW317 27 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 28572882 Common - hypothetical protein TW741 74 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 28572789 Common - integral membrane protein TW644 48 COG1615 COG1615, Uncharacterized conserved protein Function unknown 28572238 Common - iron-siderophore uptake system ATP-binding component TW068 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 28572567 Common pstS ABC transporter phosphate-binding lipoprotein TW415 130 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 28572219 Pathogen - integral membrane protein TW046 1 None None None 28572180 Common gyrB DNA gyrase subunit B TW005 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 28572898 Pathogen - integral membrane protein TW757 1 None None None 28572830 Pathogen - integral membrane protein TW689 1 None None None 28572649 Common - secreted protein TW500 8 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 28572574 Common - terpenoid biosynthesis bifunctional enzyme TW422 195 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 28572189 Common - integral membrane protein TW014 12 None None None 28572195 Common - acyl-CoA carboxylase complex A subunit TW020 238 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 28572618 Common secG preprotein translocase subunit SecG TW469 20 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 28572731 Common - TadA-like protein TW583 213 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 28572247 Common - secreted protein TW079 6 None None None 28572919 Pathogen - hypothetical protein TW778 1 None None None 28572712 Common ilvE branched-chain amino acid aminotransferase TW564 212 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 28572446 Common ndk nucleoside diphosphate kinase TW290 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 28572650 Common ruvB Holliday junction DNA helicase B TW501 212 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 28572722 Common prfB peptide chain release factor 2 TW574 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 28572212 Common - ABC transport integral membrane subunit TW039 115 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 28572299 Common - secreted protein TW136 6 None None None 28572925 Common - hypothetical protein TW784 44 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 28572849 Common ribB 3,4-dihydroxy-2-butanone 4-phosphate synthase TW708 229 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 28572510 Common gatA glutamyl-tRNA (gln) amidotransferase subunit A TW356 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 28572696 Common pbp penicillin-binding protein TW548 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 28572380 Common rpsH 30S ribosomal protein S8 TW220 248 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 28572294 Common tufA elongation factor Tu TW131 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 28572333 Common - hypothetical protein TW171 183 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 28572516 Pathogen - integral membrane protein TW363 1 None None None 28572404 Common - ATP-dependent DNA helicase TW245 229 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 28572327 Common - integral membrane protein TW164 19 None None None 28572681 Common pyrD dihydroorotate dehydrogenase 2 TW532 227 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 28572320 Pathogen - WiSP family protein TW157 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 28572806 Common xseA exodeoxyribonuclease VII large subunit TW665 205 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 28572263 Common - integral membrane protein TW096 131 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 28572819 Common pgm phosphoglycerate mutase TW678 160 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 28572798 Common glyA serine hydroxymethyltransferase TW655 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 28572858 Common - hypothetical protein TW717 3 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 28572504 Common - low complexity hydrophilic protein TW350 73 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 28572907 Common aspS aspartyl-tRNA synthetase TW766 249 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 28572536 Common - hypothetical protein TW383 148 COG4850 COG4850, Uncharacterized conserved protein Function unknown 28572456 Common - DNA-binding/repair enzyme TW300 215 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 28572336 Common folE GTP cyclohydrolase I TW174 169 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 28572929 Common - serine/threonine-protein kinase TW788 160 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 28572851 Common ribH 6,7-dimethyl-8-ribityllumazine synthase TW710 220 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 28572347 Common - ferredoxin TW187 140 COG1146 COG1146, Ferredoxin Energy production and conversion 28572716 Common ilvD dihydroxy-acid dehydratase TW568 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 28572383 Common rpsE 30S ribosomal protein S5 TW223 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 28572370 Common rplB 50S ribosomal protein L2 TW210 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 28572418 Common - lipoamide acyltransferase TW259 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 28572379 Common rplE 50S ribosomal protein L5 TW219 246 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 28572232 Common - chorismate binding enzyme TW062 220 COG1169 MenF, Isochorismate synthase Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism 28572901 Common dnaJ2 molecular chaperone DnaJ TW760 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 28572340 Pathogen - integral membrane protein TW178 1 None None None 28572841 Common tdcB threonine dehydratase TW700 209 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 28572297 Common - WhiB-like regulatory protein TW134 19 None None None 28572196 Pathogen - hypothetical protein TW021 1 None None None 28572269 Pathogen - hypothetical protein TW103 1 None None None 28572329 Common - transcription factor TW166 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 28572890 Common hemE uroporphyrinogen decarboxylase TW749 174 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 28572674 Common - integral membrane protein TW525 17 None None None 28572833 Common - integral membrane protein TW692 16 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 28572262 Pathogen - integral membrane protein TW095 1 None None None 28572514 Common - ABC transporter ATP-binding subunit TW361 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 28572322 Common ispE 4-diphosphocytidyl-2-c-methyl-D-erythritol kinase TW159 58 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 28572631 Common pyk pyruvate kinase TW482 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 28572770 Pathogen - hypothetical protein TW624 1 None None None 28572702 Common - polyprenyl diphosphate synthase TW554 241 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 28572912 Common - cytochrome biogenesis protein TW771 123 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 28572726 Common - membrane/secreted protein TW578 7 None None None 28572450 Common obgE GTPase ObgE TW294 239 COG0536 Obg, Predicted GTPase General function prediction only 28572190 Common - WiSP family protein TW015 2 None None None 28572605 Common - hypothetical protein TW455 21 None None None 28572437 Common tig trigger factor TW281 209 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 28572430 Common - conserved DNA-binding protein TW274 16 None None None 28572763 Common - integral membrane protein TW617 52 COG1738 COG1738, Uncharacterized conserved protein Function unknown 28572927 Common - FtsW/RodA/SpoVE family cell cycle protein TW786 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 28572478 Common xthA1 exodeoxyribonuclease III TW323 194 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 28572352 Pathogen - possible integral membrane protein TW192 1 None None None 28572474 Common tsf elongation factor Ts TW319 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 28572239 Common - iron-siderophore uptake system integral membrane component TW069 191 COG4779 FepG, ABC-type enterobactin transport system, permease component Inorganic ion transport and metabolism 28572834 Pathogen - integral membrane protein TW693 1 None None None 28572748 Pathogen - hypothetical protein TW600 1 None None None 28572951 Common - RNA nucleotidyltransferase TW810 214 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 28572218 Pathogen - small membrane protein TW045 1 None None None 28572388 Common infA translation initiation factor IF-1 TW228 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 28572182 Pathogen - integral membrane protein TW007 1 None None None 28572758 Common - conserved hypothetical protein containing glycosyltransferase domain TW612 8 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 28572738 Common - hypothetical protein TW590 4 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 28572616 Pathogen - hypothetical protein TW467 1 None None None 28572867 Common recR recombination protein RecR TW726 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 28572533 Common - thiosulfate sulfurtransferase TW380 143 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 28572910 Common ccdA cytochrome c-type biogenesis protein CcdA TW769 93 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 28572402 Common - ATP-dependent DNA helicase subunit TW243 230 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 28572185 Common - putative septation inhibitor protein TW010 13 None None None 28572543 Pathogen - hypothetical protein TW390 1 None None None 28572873 Common nusG transcription antitermination protein NusG TW732 214 COG0250 NusG, Transcription antiterminator Transcription 28572193 Common punA purine nucleoside phosphorylase TW018 126 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 28572469 Common - DNA processing protein TW314 209 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 28572201 Common - protein ligase TW026 223 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 28572672 Common qcrC cytochrome C heme-binding subunit TW523 36 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 28572397 Common - hypothetical protein TW237 168 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 28572623 Common - hypothetical protein TW474 44 COG1481 COG1481, Uncharacterized protein conserved in bacteria Function unknown 28572646 Common - hypothetical protein TW497 3 None None None 28572940 Common pdhA pyruvate dehydrogenase E1 component, alpha subunit TW799 154 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 28572580 Common pgi glucose-6-phosphate isomerase TW429 97 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 28572956 Common - putative inner membrane protein translocase component YidC TW815 215 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 28572460 Common rpsP 30S ribosomal protein S16 TW304 213 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 28572766 Common tgt queuine tRNA-ribosyltransferase TW620 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 28572812 Common ulaD 3-keto-L-gulonate-6-phosphate decarboxylase TW671 54 COG0269 SgbH, 3-hexulose-6-phosphate synthase and related proteins Carbohydrate transport and metabolism 28572291 Common hup DNA-binding protein HU-alpha TW128 187 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 28572256 Common - hypothetical protein TW088 10 None None None 28572739 Common - hypothetical protein TW591 3 None None None 28572817 Pathogen - integral membrane protein TW676 1 None None None 28572306 Pathogen - hypothetical phase-variable integral membrane protein TW143 1 None None None 28572641 Common dnaJ1 chaperone protein DnaJ TW492 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 28572589 Common - hypothetical protein TW438 146 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 28572659 Common panB 3-methyl-2-oxobutanoate hydroxymethyltransferase TW510 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 28572498 Common atpD F0F1 ATP synthase subunit beta TW344 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 28572420 Common - aminopeptidase TW261 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 28572427 Common gyrB2 DNA topoisomerase IV subunit B TW268 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 28572677 Common - hypothetical protein TW528 165 COG0316 IscA, Uncharacterized conserved protein Function unknown 28572917 Common - WiSP family protein TW776 18 None None None 28572621 Common gap glyceraldehyde 3-phosphate dehydrogenase TW472 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 28572598 Pathogen - integral membrane protein TW447 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 28572318 Common - phospho-sugar mutase TW155 241 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 28572937 Common dcd deoxycytidine triphosphate deaminase TW796 158 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 28572935 Common hisS histidyl-tRNA synthetase TW794 248 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 28572377 Common rplN 50S ribosomal protein L14 TW217 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 28572881 Common serS seryl-tRNA synthetase TW740 243 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 28572365 Common ftsY SRP54-type protein TW205 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 28572407 Common - hypothetical protein TW248 48 COG1799 COG1799, Uncharacterized protein conserved in bacteria Function unknown 28572525 Common - hypothetical protein TW372 16 None None None 28572607 Common upk undecaprenol kinase TW457 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 28572600 Common - short chain dehydrogenase TW450 142 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 28572324 Pathogen - WiSP family protein TW161 1 None None None 28572656 Common - hypothetical protein TW507 97 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 28572804 Pathogen - integral membrane protein TW663 1 None None None 28572260 Common purN phosphoribosylglycinamide formyltransferase TW093 224 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 28572290 Common rpsN 30S ribosomal protein S14 TW127 161 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 28572400 Common - hypothetical protein TW241 5 None None None 28572513 Common - integral membrane protein TW360 25 COG4721 COG4721, Predicted membrane protein Function unknown 28572651 Common ruvA holliday junction DNA helicase RuvA TW502 208 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 28572705 Common - acyltransferase TW557 91 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 28572368 Common rplD 50S ribosomal protein L4 TW208 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 28572816 Pathogen - hypothetical protein TW675 1 None None None 28572295 Common - integral membrane protein TW132 24 COG1928 PMT1, Dolichyl-phosphate-mannose--protein O-mannosyl transferase Posttranslational modification, protein turnover, chaperones 28572888 Common hemH ferrochelatase TW747 78 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 28572920 Pathogen - hypothetical protein TW779 1 None None None 28572267 Common - hypothetical protein TW100 123 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 28572573 Common - CarD-family transcriptional regulator TW421 83 COG1329 COG1329, Transcriptional regulators, similar to M. xanthus CarD Transcription 28572228 Pathogen - hypothetical protein TW058 1 None None None 28572892 Common - O-succinylbenzoate synthase TW751 24 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 28572683 Common - hypothetical protein TW534 20 COG0789 SoxR, Predicted transcriptional regulators Transcription 28572853 Common - secreted proteinase TW712 35 None None None 28572441 Common clpX ATP-dependent protease ATP-binding subunit TW285 213 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 28572331 Common - hypothetical protein TW169 170 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 28572338 Pathogen - integral membrane protein TW176 1 None None None 28572903 Common dnaK molecular chaperone DnaK TW762 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 28572844 Common - integral membrane protein TW703 28 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 28572714 Common ilvN acetohydroxy acid synthase, small subunit TW566 85 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 28572245 Common - Clp-family ATP-binding protease/regulator TW075 227 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 28572363 Common - branched chain amino acid ABC transporter ATP-binding subunit TW203 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 28572507 Common trmU tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase TW353 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 28572809 Common - PfkB-family carbohydrate kinase. TW668 109 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 28572385 Common secY preprotein translocase subunit SecY TW225 241 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 28572405 Common - hypothetical protein TW246 20 COG5282 COG5282, Uncharacterized conserved protein Function unknown 28572529 Common - ribonuclease TW376 95 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 28572432 Common - hypothetical protein TW276 15 None None None 28572746 Pathogen - hypothetical protein TW598 1 None None None 28572359 Common rnc ribonuclease III TW199 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 28572350 Common mdmC O-methyltransferase TW190 73 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 28572234 Common - polyprenyl diphosphate synthase TW064 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 28572836 Common rpsG 30S ribosomal protein S7 TW695 243 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 28572794 Pathogen - integral membrane protein TW649 1 None None None 28572439 Common clpP1 ATP-dependent Clp protease proteolytic subunit 1 TW283 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 28572862 Common - hypothetical protein TW721 92 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 28572476 Common frr ribosome recycling factor TW321 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 28572564 Common fmt methionyl-tRNA formyltransferase TW411 215 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 28572457 Common lipA lipoyl synthase TW301 190 COG0320 LipA, Lipoate synthase Coenzyme metabolism 28572790 Common - secreted protein TW645 35 COG3480 SdrC, Predicted secreted protein containing a PDZ domain Signal transduction mechanisms 28572692 Common murD UDP-N-acetylmuramoylalanine--D-glutamate ligase TW544 210 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 28572578 Pathogen - integral membrane protein TW426 1 None None None 28572785 Common rph ribonuclease PH TW640 187 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 28572699 Common mraZ hypothetical protein TW551 126 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 28572787 Pathogen - WiSP family protein TW642 1 None None None 28572287 Common ideR iron-dependent repressor TW124 71 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 28572768 Common - NLP/P60 family secreted protein TW622 92 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 28572942 Common purA adenylosuccinate synthetase TW801 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 28572945 Pathogen - hypothetical protein TW804 1 None None None 28572644 Common rpsT 30S ribosomal protein S20 TW495 58 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 28572395 Common - MRP-family ATP-binding protein TW235 234 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 28572609 Common fabG 3-oxoacyl-[acyl-carrier protein] reductase TW459 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 28572216 Pathogen - large integral membrane protein TW043 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 28572810 Common sgaE L-ribulose-5-phosphate 4-epimerase TW669 152 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 28572878 Common purF amidophosphoribosyltransferase TW737 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 28572204 Common purE phosphoribosylaminoimidazole carboxylase catalytic subunit PurE TW029 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 28572871 Common rplA 50S ribosomal protein L1 TW730 243 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 28572539 Common - DNA uptake protein TW386 113 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 28572736 Common proS prolyl-tRNA synthetase TW588 247 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 28572541 Common - DNA uptake protein TW388 117 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 28572433 Common dut deoxyuridine 5'-triphosphate nucleotidohydrolase TW277 178 COG0756 Dut, dUTPase Nucleotide transport and metabolism 28572187 Common - hypothetical protein TW012 130 COG1704 LemA, Uncharacterized conserved protein Function unknown 28572865 Common asd aspartate-semialdehyde dehydrogenase TW724 238 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 28572555 Common pyrC dihydroorotase TW402 212 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 161501888 Common rpmI 50S ribosomal protein L35 TW607 109 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 28572459 Common ffh signal recognition particle protein TW303 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 28572728 Common - hypothetical protein TW580 8 None None None 28572846 Common trpS tryptophanyl-tRNA synthetase TW705 225 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 28572375 Common rpmC 50S ribosomal protein L29 TW215 114 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 28572721 Common ftsE cell division ATP-binding protein FtsE TW573 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 28572532 Common - hypothetical protein TW379 15 COG2166 COG2166, SufE protein probably involved in Fe-S center assembly General function prediction only 28572273 Pathogen - integral membrane protein TW107 1 None None None 28572283 Common rpsF 30S ribosomal protein S6 TW117 32 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 28572466 Pathogen - hypothetical protein TW311 1 None None None 28572500 Common rpsO 30S ribosomal protein S15 TW346 213 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 28572843 Common - ribonucleotide-diphosphate reductase subunit alpha TW702 222 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 28572895 Common nagD N-acetylglucosamine-6-phosphate deacetylase NagD TW754 103 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 28572597 Common - TatD-family DNase TW446 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 28572523 Common - hypothetical protein TW370 20 COG0824 FcbC, Predicted thioesterase General function prediction only 28572602 Pathogen tatA sec-independent protein translocase protein TatA TW452 1 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 28572825 Common mscL large-conductance mechanosensitive channel TW684 95 COG1970 MscL, Large-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 28572221 Pathogen - integral membrane protein TW049 1 None None None 28572235 Common - ferredoxin/ferredoxin-NADP reductase TW065 174 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 28572491 Pathogen atpI ATP synthase protein I TW337 3 None None None 28572311 Common - ABC transporter ATP-binding subunit TW148 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 28572258 Common - ATP-dependent DNA helicase TW090 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 28572509 Common gatC glutamyl-tRNA(gln) amidotransferase subunit C TW355 3 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 28572487 Common prfA peptide chain release factor 1 TW333 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 28572591 Common uppS1 undecaprenyl pyrophosphate synthetase TW440 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 28572425 Common alr1 alanine racemase I TW266 106 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 28572614 Common pgl 6-phosphogluconolactonase TW464 124 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 28572392 Common rpoA DNA-directed RNA polymerase subunit alpha TW232 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 28572587 Common - dioxygenase 2Fe-2S ferredoxin subunit TW436 85 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 28572584 Common - cytochrome synthase TW433 50 COG1612 CtaA, Uncharacterized protein required for cytochrome oxidase assembly Posttranslational modification, protein turnover, chaperones 28572455 Common - integral membrane protein (possible nuclease activity) TW299 10 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 28572663 Common - hypothetical protein TW514 169 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 28572505 Common - integral membrane protein TW351 6 None None None 28572667 Common acpP acyl carrier protein TW518 201 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 28572194 Common - flavoprotein disulfide reductase TW019 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 28572697 Pathogen - hypothetical protein TW549 3 None None None 28572278 Common - ATP-NAD kinase TW112 240 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 28572181 Common gyrA1 DNA gyrase subunit A TW006 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 28572577 Common - secreted protein TW425 13 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 28572286 Common menE O-succinylbenzoic acid--CoA ligase TW121 197 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 28572723 Common - integral membrane transport protein TW575 17 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 28572743 Pathogen - hypothetical protein TW595 1 None None None 28572436 Common Dxs 1-deoxy-D-xylulose-5-phosphate synthase TW280 220 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 28572802 Common - translation-associated GTPase TW661 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 28572303 Pathogen - hypothetical protein TW140 1 None None None 28572447 Common rne ribonuclease E TW291 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 28572357 Common - hypothetical protein TW197 23 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 28572778 Common - hypothetical protein TW632 160 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 28572707 Pathogen - WiSP family protein TW559 2 None None None 28572854 Common - DNA polymerase TW713 164 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 28572894 Common - hypothetical protein TW753 18 COG2372 CopC, Uncharacterized protein, homolog of Cu resistance protein CopC General function prediction only 28572422 Common hrdB RNA polymerase sigma factor RpoD TW263 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 28572562 Common metK S-adenosylmethionine synthetase TW409 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 28572571 Common argS arginyl-tRNA synthetase TW419 246 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 28572638 Common - hypothetical protein TW489 21 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 28572344 Pathogen - integral membrane protein TW182 1 None None None 28572918 Common - glycosyl transferase TW777 187 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 28572906 Pathogen - hypothetical protein TW765 1 None None None 28572783 Common - integral membrane protein TW638 137 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 28572367 Common rplC 50S ribosomal protein L3 TW207 219 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 161501891 Common rpsB 30S ribosomal protein S2 TW318 227 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 28572414 Common - hypothetical protein TW255 96 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 28572252 Common groES co-chaperonin GroES TW084 215 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 28572339 Common - ABC transporter ATP-binding subunit TW177 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 28572828 Common - ABC transporter integral membrane subunit TW687 183 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 28572496 Common atpA F0F1 ATP synthase subunit alpha TW342 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 28572440 Common clpP2 ATP-dependent Clp protease proteolytic subunit TW284 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 28572326 Common - ABC transporter (ATP-binding and integral membrane) TW163 249 COG4988 CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 28572312 Common - ABC transporter integral membrane subunit TW149 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 28572807 Common xseB probable exodeoxyribonuclease VII small subunit TW666 11 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 28572685 Common - hypothetical protein TW536 43 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 28572266 Common dxr 1-deoxy-D-xylulose 5-phosphate reductoisomerase TW099 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 28572654 Common - hypothetical protein TW505 85 COG0311 PDX2, Predicted glutamine amidotransferase involved in pyridoxine biosynthesis Coenzyme metabolism 28572680 Common rnhA ribonuclease H TW531 175 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 28572511 Common gatB aspartyl/glutamyl-tRNA amidotransferase subunit B TW357 212 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 28572922 Common - peptidase TW781 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 28572711 Common gltX glutamyl-tRNA synthetase TW563 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 28572517 Common orn oligoribonuclease TW364 88 COG1949 Orn, Oligoribonuclease (3'->5' exoribonuclease) RNA processing and modification 28572332 Common gcp O-sialoglycoprotein endopeptidase TW170 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 28572296 Common manA mannose-6-phosphate isomerase TW133 41 COG1482 ManA, Phosphomannose isomerase Carbohydrate transport and metabolism 28572694 Common mraY phospho-N-acetylmuramoyl-pentapeptide-transferase TW546 211 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 28572821 Pathogen - hypothetical protein TW680 1 None None None 28572314 Common - ABC transporter ATP-binding subunit TW151 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 28572259 Common - integral membrane protein TW092 9 COG1368 MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily Cell envelope biogenesis, outer membrane 28572660 Common map methionine aminopeptidase TW511 249 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 28572868 Common dnaX DNA polymerase III subunits gamma and tau TW727 244 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 28572528 Common - hypothetical protein TW375 73 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 28572540 Common - DNA uptake protein TW387 68 COG0658 ComEC, Predicted membrane metal-binding protein General function prediction only 28572506 Common - aminotransferase TW352 215 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 28572751 Common pheT phenylalanyl-tRNA synthetase beta chain TW604 215 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 28572521 Pathogen - secreted protein TW368 2 None None None 28572861 Common - TadA-like protein TW720 153 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 28572369 Common rplW 50S ribosomal protein L23 TW209 161 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 28572795 Common - histidine kinase TW651 94 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 28572424 Common - hypothetical protein TW265 37 COG3442 COG3442, Predicted glutamine amidotransferase General function prediction only 28572930 Common - serine/threonine-protein kinase TW789 51 COG2815 COG2815, Uncharacterized protein conserved in bacteria Function unknown 28572896 Common pyrE orotate phosphoribosyltransferase TW755 87 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 28572276 Common pyrG CTP synthetase TW110 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 28572494 Common atpF ATP synthase B chain TW340 64 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 28572603 Common - drug-binding lipoprotein TW453 130 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 28572955 Common - hypothetical protein TW814 19 COG1847 Jag, Predicted RNA-binding protein General function prediction only 28572177 Common dnaN DNA polymerase III subunit beta TW002 202 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 28572908 Common - phosphoglycerate mutase TW767 37 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 28572886 Common - porphyrin biosynthesis protein TW745 36 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 28572547 Common - hypothetical protein TW394 107 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 28572458 Common lipB lipoate-protein ligase B TW302 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 28572390 Common rpsM 30S ribosomal protein S13 TW230 245 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 28572518 Common nadE NAD synthetase TW365 155 COG0171 NadE, NAD synthase Coenzyme metabolism 28572561 Common - flavoprotein TW408 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 28572877 Common - hypothetical protein TW736 23 COG2030 MaoC, Acyl dehydratase Lipid metabolism 28572206 Common - polysaccharide biosynthesis protein TW032 164 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 28572627 Common coaE dephospho-CoA kinase TW478 100 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 28572481 Common groEL chaperonin GroEL TW327 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 28572735 Pathogen - hypothetical protein TW587 1 None None None 28572769 Pathogen - hypothetical protein TW623 1 None None None 28572947 Common - hypothetical protein TW806 21 COG1828 PurS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component Nucleotide transport and metabolism 28572612 Common def peptide deformylase TW462 211 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 28572776 Pathogen - hypothetical protein TW630 1 None None None 28572208 Common - epimerase TW035 164 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 28572734 Common ispG 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase TW586 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 28572827 Common - ABC transporter ATP-binding subunit TW686 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 28572595 Common - carboxypeptidase TW444 43 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 28572837 Common rpsL 30S ribosomal protein S12 TW696 246 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 28572334 Common hpt hypoxanthine phosphoribosyltransferase TW172 150 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 28572883 Common - hypothetical protein TW742 52 COG1316 LytR, Transcriptional regulator Transcription 28572740 Common - ABC transporter ATP-binding subunit TW592 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 28572732 Common - peptidoglycan synthesis protein TW584 226 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 28572453 Pathogen - hypothetical protein TW297 2 None None None 28572762 Pathogen - hypothetical protein TW616 1 None None None 28572213 Common - glycosyl transferase TW040 162 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 28572237 Common - iron-siderophore binding lipoprotein TW067 24 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 28572445 Pathogen - hypothetical protein TW289 1 None None None 28572280 Common rplI 50S ribosomal protein L9 TW114 213 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 28572355 Common recG ATP-dependent DNA helicase RecG TW195 214 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 28572741 Pathogen - secreted protein TW593 1 None None None 28572575 Common cysS1 cysteinyl-tRNA synthetase TW423 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 28572188 Common - integral membrane heat shock protease TW013 196 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 28572695 Common murF probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-- D-alanyl-D-alanyl ligase TW547 212 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 28572924 Common - DNA methylase TW783 144 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 28572713 Common ilvC ketol-acid reductoisomerase TW565 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 28572349 Pathogen - hypothetical protein TW189 1 COG5373 COG5373, Predicted membrane protein Function unknown 28572230 Common - prephenate dehydrogenase TW060 148 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 28572669 Common - hypothetical protein TW520 17 None None None 28572452 Common nadD nicotinic acid mononucleotide adenyltransferase TW296 174 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 28572781 Common - WhiB-family regulator TW636 19 None None None 28572753 Common rplT 50S ribosomal protein L20 TW606 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 28572818 Common rplY 50S ribosomal protein L25/general stress protein Ctc TW677 143 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 28572515 Common - ABC transporter integral membrane subunit TW362 14 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 28572321 Common glmS D-fructose-6-phosphate amidotransferase TW158 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 28572625 Common uvrA excinuclease ABC subunit A TW476 237 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 28572665 Common fabD acyl-carrier-protein S-malonyltransferase TW516 208 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 28572471 Pathogen - hypothetical protein TW316 1 None None None 28572838 Pathogen - hypothetical protein TW697 1 None None None 28572272 Common - ABC transport ATP-binding subunit TW106 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 28572264 Common truB tRNA pseudouridine synthase B TW097 243 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 28572831 Common - hypothetical protein TW690 150 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 28572293 Common - helicase regulator TW130 120 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 28572687 Pathogen - hypothetical protein TW539 1 None None None 28572610 Common - glycosyltransferase TW460 227 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 28572899 Common clpB heat shock protein ClpB TW758 215 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 28572718 Common - WiSP family protein TW570 23 None None None 28572916 Common metG methionyl-tRNA synthetase TW775 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 28572403 Common - transferase TW244 7 None None None 28572255 Common - hypothetical protein TW087 7 COG3346 COG3346, Uncharacterized conserved protein Function unknown 28572386 Common adk adenylate kinase TW226 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 28572503 Common - hypothetical protein TW349 48 COG0628 PerM, Predicted permease General function prediction only 28572342 Common ribF riboflavin biosynthesis protein TW180 211 COG0196 RibF, FAD synthase Coenzyme metabolism 28572488 Common - peptide chain release factor methyltransferase TW334 215 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 28572192 Common - phosphomannomutase TW017 239 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 28572805 Common ispH 4-hydroxy-3-methylbut-2-enyl diphosphate reductase TW664 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 28572856 Common topA DNA topoisomerase I TW715 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 28572799 Common - hypothetical protein TW656 206 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 28572183 Common - hypothetical protein TW008 44 COG1564 THI80, Thiamine pyrophosphokinase Coenzyme metabolism 28572416 Common ddlA D-alanine--D-alanine ligase A TW257 210 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 28572725 Common - hypothetical protein TW577 3 None None None 28572254 Common guaB2 inositol-5-monophosphate dehydrogenase TW086 232 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 28572373 Common rpsC 30S ribosomal protein S3 TW213 226 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 28572231 Common - bifunctional cytidylate kinase/GTP-binding protein TW061 225 COG1160 COG1160, Predicted GTPases General function prediction only 28572462 Common rimM probable 16s rRNA processing protein RimM TW306 20 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 28572859 Pathogen - hypothetical protein TW718 1 None None None 28572241 Common - regulator TW071 168 COG0640 ArsR, Predicted transcriptional regulators Transcription 28572483 Common hom homoserine dehydrogenase TW329 217 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 28572657 Common thrS threonyl-tRNA synthetase TW508 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 28572884 Common hemL glutamate-1-semialdehyde 2,1-aminomutase TW743 234 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 28572939 Common pdhB pyruvate dehydrogenase E1 component, beta subunit TW798 193 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 28572429 Common gyrA1 DNA topoisomerase IV subunit A TW273 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 28572535 Common - integral membrane protein. TW382 12 COG4129 COG4129, Predicted membrane protein Function unknown 28572675 Common ctaD cytochrome c oxidase subunit I TW526 174 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 28572662 Common - hypothetical protein TW513 96 COG0327 COG0327, Uncharacterized conserved protein Function unknown 28572756 Common metT 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase TW610 104 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 28572772 Common miaA tRNA delta (2)-isopentenylpyrophosphate transferase TW626 210 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 28572682 Common - hypothetical protein TW533 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 28572316 Common rplM 50S ribosomal protein L13 TW153 227 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 28572583 Common - cytochrome synthase TW432 183 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 28572592 Common - sugar ABC transporter ATP-binding subunit TW441 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 28572484 Common thrC threonine synthase TW330 161 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 28572701 Pathogen - hypothetical protein TW553 3 None None None 28572444 Common fgs folylpolyglutamate synthase TW288 218 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 28572301 Common - conserved hypothetical protein (possible ATP-binding) TW138 20 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 28572248 Common menA 1,4-dihydroxy-2-naphthoate octaprenyltransferase TW080 108 COG1575 MenA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase Coenzyme metabolism 28572814 Common pth peptidyl-tRNA hydrolase TW673 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 28572764 Common ppa2 inorganic pyrophosphatase TW618 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 28572774 Common recA recombinase A TW628 238 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 28572568 Common pstC phosphate ABC transporter permease TW416 226 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 28572526 Common rpiB ribose-5-phosphate isomerase B TW373 123 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 28572619 Common tpiA triosephosphate isomerase TW470 215 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 28572399 Pathogen - hypothetical protein TW240 1 None None None 28572797 Common folD methylenetetrahydrofolate dehydrogenase ; methenyltetrahydrofolate cyclohydrolase TW653 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 28572224 Pathogen - integral membrane protein TW053 1 None None None 28572941 Common purB adenylosuccinate lyase TW800 236 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 28572411 Common dnaE DNA polymerase III subunit alpha TW252 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 28572179 Pathogen - hypothetical protein TW004 2 None None None 28572378 Common rplX 50S ribosomal protein L24 TW218 150 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 28572823 Common - acetyltransferase TW682 14 COG0456 RimI, Acetyltransferases General function prediction only 28572308 Common - ABC transporter substrate-binding protein TW145 188 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 28572545 Common rpsD 30S ribosomal protein S4 TW392 234 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 28572953 Common parA1 chromosome partitioning protein ParA TW812 190 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 28572648 Common secD preprotein translocase subunit SecD TW499 218 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 28572788 Common - hypothetical protein TW643 221 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 28572558 Common pyrF orotidine 5'-phosphate decarboxylase TW405 59 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 28572875 Common murB UDP-N-acetylenolpyruvoylglucosamine reductase TW734 182 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 28572800 Common gcvH probable glycine cleavage system H protein TW658 185 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 28572551 Common aroK shikimate kinase TW398 125 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 28572282 Common ssb1 single-strand DNA-binding protein TW116 175 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 28572200 Common pccB propionyl-CoA carboxylase beta chain TW025 217 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism