Pyrococcus furiosus DSM 3638, complete genome NC_003413 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 18977708 Common - cytosine permease PF1336 83 COG1457 CodB, Purine-cytosine permease and related proteins Nucleotide transport and metabolism 18976819 Common - transposase PF0447 25 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18977863 Nonpathogen rps17E 30S ribosomal protein S17e PF1491 33 COG1383 RPS17A, Ribosomal protein S17E Translation, ribosomal structure and biogenesis 18976763 Common - hypothetical protein PF0391 36 COG1786 COG1786, Uncharacterized conserved protein Function unknown 18978094 Nonpathogen - archaeal histone a2 PF1722 23 COG2036 HHT1, Histones H3 and H4 Chromatin structure and dynamics 18978426 Nonpathogen - 30S ribosomal protein S3Ae PF2054 34 COG1890 RPS1A, Ribosomal protein S3AE Translation, ribosomal structure and biogenesis 18976827 Common - hypothetical protein PF0455 5 COG4043 COG4043, Uncharacterized conserved protein Function unknown 18977340 Common - 2-ketoisovalerate ferredoxin oxidoreductase subunit beta PF0968 107 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 33359513 Nonpathogen - hypothetical protein PF0829 4 COG4049 COG4049, Uncharacterized protein containing archaeal-type C2H2 Zn-finger General function prediction only 18977891 Common - sugar-binding transport ATP-binding protein PF1519 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 18976556 Common - V-type ATP synthase subunit D PF0184 47 COG1394 NtpD, Archaeal/vacuolar-type H+-ATPase subunit D Energy production and conversion 18977028 Nonpathogen - hypothetical protein PF0656 1 None None None 18978014 Nonpathogen rpoK DNA-directed RNA polymerase subunit K PF1642 27 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 18976844 Nonpathogen - hypothetical protein PF0472 1 None None None 18978043 Common - hypothetical protein PF1671 75 COG2510 COG2510, Predicted membrane protein Function unknown 18976460 Common - icc related protein PF0088 102 COG1409 Icc, Predicted phosphohydrolases General function prediction only 18978020 Common rps11p 30S ribosomal protein S11P PF1648 94 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 18976615 Common - DEXX-box atpase PF0243 27 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 18976704 Common - flagellar accessory protein FlaH PF0332 21 COG2874 FlaH, Predicted ATPases involved in biogenesis of archaeal flagella Cell motility and secretion / Intracellular trafficking and secretion 18976850 Common - alpha-amylase PF0478 156 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 18977419 Nonpathogen - hypothetical protein PF1047 6 COG2383 COG2383, Uncharacterized conserved protein Function unknown 33359542 Common - hypothetical protein PF1117 36 COG1343 COG1343, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 33359511 Common - hypothetical protein PF0799 28 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 18977130 Nonpathogen - hypothetical protein PF0758 14 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 18977400 Nonpathogen - hypothetical protein PF1028 1 None None None 18976871 Nonpathogen - arginase 1 -like protein PF0499 9 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 18978345 Nonpathogen - hypothetical protein PF1973 1 None None None 18977067 Common - hypothetical protein PF0695 26 COG2461 COG2461, Uncharacterized conserved protein Function unknown 18978222 Common - hypothetical damage-inducible dinF protein PF1850 189 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 18977698 Nonpathogen - hypothetical protein PF1326 1 None None None 18976430 Common - dolichol monophosphate mannose synthase PF0058 216 COG2246 COG2246, Predicted membrane protein Function unknown 18976437 Nonpathogen - hypothetical protein PF0065 2 None None None 18977429 Common pgk phosphoglycerate kinase PF1057 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 18977126 Common - 2-keto acid:ferredoxin oxidoreductase subunit alpha PF0754 111 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 18978408 Common - magnesium and cobalt transporter PF2036 172 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 18977927 Common truD tRNA pseudouridine synthase D PF1555 86 COG0585 COG0585, Uncharacterized conserved protein Function unknown 18976493 Common - putative aspartate aminotransferase PF0121 230 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 18978361 Nonpathogen secE preprotein translocase subunit SecE PF1989 1 COG2443 Sss1, Preprotein translocase subunit Sss1 Intracellular trafficking and secretion 18976484 Nonpathogen - hypothetical protein PF0112 17 COG1341 COG1341, Predicted GTPase or GTP-binding protein General function prediction only 18978065 Common aroE shikimate 5-dehydrogenase PF1693 224 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 18976648 Common - oxidoreductase PF0276 64 COG2509 COG2509, Uncharacterized FAD-dependent dehydrogenases General function prediction only 33359591 Nonpathogen - hypothetical protein PF2047.1n 2 None None None 33359518 Nonpathogen - hypothetical protein PF0861.1n 1 None None None 18978382 Nonpathogen - ribosomal biogenesis protein PF2010 4 COG2136 IMP4, Predicted exosome subunit/U3 small nucleolar ribonucleoprotein (snoRNP) component, contains IMP4 domain Translation, ribosomal structure and biogenesis / RNA processing and modification 18976878 Nonpathogen - hypothetical protein PF0506 1 None None None 18977973 Common - transcriptional regulatory protein, asnC family PF1601 173 COG1522 Lrp, Transcriptional regulators Transcription 18976760 Nonpathogen - hypothetical protein PF0388 4 COG2245 COG2245, Predicted membrane protein Function unknown 18976778 Nonpathogen - hypothetical protein PF0406 9 None None None 18977420 Common - hypothetical protein PF1048 42 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 33359557 Nonpathogen - hypothetical protein PF1308.2n 1 None None None 18976771 Nonpathogen - member of s1p family of ribosomal proteins PF0399 21 COG1107 COG1107, Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain DNA replication, recombination, and repair 18977156 Common - hypothetical protein PF0784 171 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 18977084 Common - hypothetical protein PF0712 11 None None None 18977527 Nonpathogen - hypothetical protein PF1155 2 COG4933 COG4933, Uncharacterized conserved protein Function unknown 18977962 Common - mutt putative PF1590 149 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 18978328 Common - fructose-bisphosphate aldolase PF1956 97 COG1830 FbaB, DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes Carbohydrate transport and metabolism 18977440 Nonpathogen - hypothetical protein PF1068 1 None None None 18977872 Nonpathogen - hypothetical protein PF1500 2 COG1873 COG1873, Uncharacterized conserved protein Function unknown 18977147 Nonpathogen - hypothetical protein PF0775 8 None None None 18977115 Common - hypothetical protein PF0743 47 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 18976891 Nonpathogen - hypothetical protein PF0519 1 None None None 18977508 Nonpathogen - hypothetical protein PF1136 2 None None None 18977997 Nonpathogen - hypothetical protein PF1625 3 COG1844 COG1844, Uncharacterized protein conserved in archaea Function unknown 18977410 Nonpathogen - hypothetical protein PF1038 2 None None None 18977282 Common - iron (III) ABC transporter, permease protein PF0910 191 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 18976867 Common - reverse gyrase PF0495 246 COG1110 COG1110, Reverse gyrase DNA replication, recombination, and repair 18977787 Common - met-10+ protein PF1415 36 COG2520 COG2520, Predicted methyltransferase General function prediction only 18976756 Common - hypothetical protein PF0384 80 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 18976868 Common - hypothetical protein PF0496 29 COG1378 COG1378, Predicted transcriptional regulators Transcription 18977547 Common - hypothetical protein PF1175 154 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 18977861 Nonpathogen - hypothetical protein PF1489 2 None None None 18976691 Common - glyoxylate reductase PF0319 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 18978383 Nonpathogen - hypothetical protein PF2011 8 COG2892 COG2892, Uncharacterized protein conserved in archaea Function unknown 18976388 Common - 5'-methylthioadenosine phosphorylase II PF0016 167 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 18978159 Common - acetyl-CoA synthetase PF1787 144 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 18976861 Nonpathogen - hypothetical protein PF0489 1 None None None 18978052 Common leuD 3-isopropylmalate dehydratase small subunit PF1680 76 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 18978055 Common argC N-acetyl-gamma-glutamyl-phosphate reductase PF1683 210 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 18976990 Common mobA molybdopterin-guanine dinucleotide biosynthesis protein A PF0618 51 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 18976948 Nonpathogen - hypothetical protein PF0576 1 None None None 18976424 Nonpathogen - exosome complex RNA-binding protein Csl4 PF0052 23 COG1096 COG1096, Predicted RNA-binding protein (consists of S1 domain and a Zn-ribbon domain) Translation, ribosomal structure and biogenesis 18976429 Common - hypothetical protein PF0057 12 COG2234 Iap, Predicted aminopeptidases General function prediction only 18977117 Common - hypothetical protein PF0745 158 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 18977684 Nonpathogen - hypothetical protein PF1312 5 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 18978141 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit beta PF1769 110 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 18976682 Common - daunorubicin resistance ATP-binding protein drrA PF0310 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18978032 Common hisB imidazoleglycerol-phosphate dehydratase PF1660 213 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 18978245 Nonpathogen - hypothetical protein PF1873 2 None None None 18978393 Common - hypothetical protein PF2021 132 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 18977542 Nonpathogen - hypothetical protein PF1170 1 None None None 18976857 Common - cell division inhibitor minD - like protein PF0485 229 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 18977239 Nonpathogen - hypothetical protein PF0867 2 None None None 18977047 Nonpathogen - hypothetical protein PF0675 2 None None None 18978121 Common - putative sulfate transport integral membrane protein PF1749 229 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 18976746 Common - translation-associated GTPase PF0374 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 161484704 Nonpathogen rpl44e 50S ribosomal protein L44e PF0217 33 COG1631 RPL42A, Ribosomal protein L44E Translation, ribosomal structure and biogenesis 18977604 Common - 4-aminobutyrate aminotransferase PF1232 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 18977983 Common - cell division inhibitor minD PF1611 228 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 18977575 Common - formaldehyde:ferredoxin oxidoreductase PF1203 59 COG2414 COG2414, Aldehyde:ferredoxin oxidoreductase Energy production and conversion 18977991 Nonpathogen - hypothetical protein PF1619 2 None None None 18977137 Common - NDP-sugar dehydrogenase PF0765 206 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 18977829 Nonpathogen - glutaredoxin/thioredoxin-like protein PF1457 12 COG5429 COG5429, Uncharacterized secreted protein Function unknown 18977409 Nonpathogen - hypothetical protein PF1037 1 None None None 18977557 Common - acetylornithine deacetylase PF1185 183 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 18976605 Common - hypothetical protein PF0233 147 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 18977728 Common - glucose-1-phosphate uridylyltransferase PF1356 233 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 18976907 Nonpathogen - hypothetical protein PF0535 18 COG1356 COG1356, Uncharacterized protein conserved in archaea Function unknown 33359572 Nonpathogen - hypothetical protein PF1735.2n 1 None None None 18977375 Common - phosphate-binding periplasmic protein precursor PF1003 139 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 18977038 Common - nol1-nop2-sun family putative nucleolar protein IV PF0666 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 33359573 Nonpathogen - hypothetical protein PF1755.1n 1 None None None 18977365 Common - hypothetical protein PF0993 31 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion 18976728 Common - beta-galactosidase PF0356 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 18977947 Nonpathogen - hypothetical protein PF1575 2 None None None 18976451 Nonpathogen - cyclic 2,3-diphospoglycerate-synthetase PF0079 11 COG2403 COG2403, Predicted GTPase General function prediction only 18977459 Nonpathogen - hypothetical protein PF1087 30 COG2118 COG2118, DNA-binding protein General function prediction only 18977399 Nonpathogen - hypothetical protein PF1027 29 COG1041 COG1041, Predicted DNA modification methylase DNA replication, recombination, and repair 18976564 Common - hypothetical oligopeptide transport system permease protein appc PF0192 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 18976513 Nonpathogen - hypothetical protein PF0141 26 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 18977110 Common - ubiquinone/menaquinone biosynthesis methyltransferase PF0738 164 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 18977840 Nonpathogen - hypothetical protein PF1468 1 None None None 18978193 Common rps19p 30S ribosomal protein S19P PF1821 248 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 18976410 Common - glyoxalase II family member PF0038 13 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 18976475 Common - hypothetical protein PF0103 21 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 18978289 Common - putative dehydrogenase PF1917 199 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 18978080 Common - anthranilate synthase component II PF1708 240 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 18977033 Common - hypothetical protein PF0661 44 COG1378 COG1378, Predicted transcriptional regulators Transcription 18977387 Common - putative transposase b - like protein PF1015 55 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 18976655 Common - putative acylphosphatase PF0283 104 COG1254 AcyP, Acylphosphatases Energy production and conversion 18976635 Common - hypothetical protein PF0263 21 COG1510 COG1510, Predicted transcriptional regulators Transcription 18977167 Common - capsular polysaccharide biosynthesis protein PF0795 71 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 33359567 Nonpathogen - hypothetical protein PF1566 2 None None None 18976919 Nonpathogen - hypothetical protein PF0547 22 COG2403 COG2403, Predicted GTPase General function prediction only 18978364 Common rpl1P 50S ribosomal protein L1P PF1992 243 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 18977932 Nonpathogen nusA transcription elongation factor NusA-like protein PF1560 34 COG0195 NusA, Transcription elongation factor Transcription 18977912 Common - ADP forming acetyl coenzyme A synthetase PF1540 204 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 18977247 Common - hypothetical protein PF0875 17 COG2521 COG2521, Predicted archaeal methyltransferase General function prediction only 18976584 Common - DNA-directed DNA polymerase PF0212 67 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 18977749 Nonpathogen tfb transcription initiation factor IIB PF1377 34 COG1405 SUA7, Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB Transcription 18976734 Common - glucosamine-fructose-6-phosphate aminotransferase PF0362 233 COG2222 AgaS, Predicted phosphosugar isomerases Cell envelope biogenesis, outer membrane 18977374 Common - hypothetical protein PF1002 142 COG0116 COG0116, Predicted N6-adenine-specific DNA methylase DNA replication, recombination, and repair 18977813 Common - NADH dehydrogenase subunit I PF1441 190 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 18977794 Common - thioredoxin reductase PF1422 249 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 18978115 Common - hypothetical protein PF1743 37 COG1378 COG1378, Predicted transcriptional regulators Transcription 18977985 Nonpathogen - ribonuclease P protein component 4 PF1613 27 COG2023 RPR2, RNase P subunit RPR2 Translation, ribosomal structure and biogenesis 18977266 Common - sulfhydrogenase alpha subunit PF0894 76 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 18977481 Nonpathogen - hypothetical protein PF1109 3 COG1572 COG1572, Uncharacterized conserved protein Function unknown 161484712 Common - geranylgeranylglyceryl phosphate synthase-like protein PF1039 32 COG1646 COG1646, Predicted phosphate-binding enzymes, TIM-barrel fold General function prediction only 33359585 Common - hypothetical protein PF1984.1n 20 COG2452 COG2452, Predicted site-specific integrase-resolvase DNA replication, recombination, and repair 33359457 Common - V-type ATP synthase subunit E PF0179 24 COG1390 NtpE, Archaeal/vacuolar-type H+-ATPase subunit E Energy production and conversion 18977240 Common - NDP-sugar synthase PF0868 239 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 18976485 Common - hypothetical protein PF0113 10 COG1522 Lrp, Transcriptional regulators Transcription 18978192 Common rpl22p 50S ribosomal protein L22P PF1820 37 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 18977142 Common - glucose-1-phosphate uridylyltransferase PF0770 234 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 33359480 Nonpathogen - hypothetical protein PF0437.1n 1 None None None 18976533 Common - hypothetical protein PF0161 157 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 18977968 Common - hypothetical protein PF1596 9 COG3682 COG3682, Predicted transcriptional regulator Transcription 18978373 Common - hypothetical protein PF2001 69 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 18976507 Common lysK lysyl-tRNA synthetase PF0135 77 COG1384 LysS, Lysyl-tRNA synthetase (class I) Translation, ribosomal structure and biogenesis 18977622 Nonpathogen - hypothetical protein PF1250 2 None None None 33359449 Nonpathogen - DNA primase large subunit PF0111 5 COG2219 PRI2, Eukaryotic-type DNA primase, large subunit DNA replication, recombination, and repair 33359485 Common - transposase PF0539 11 None None None 18977040 Common - hypothetical protein PF0668 202 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 18977670 Common - putative endonuclease PF1298 27 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 18976928 Nonpathogen - hypothetical protein PF0556 1 None None None 18976992 Common - hypothetical protein PF0620 42 COG1342 COG1342, Predicted DNA-binding proteins General function prediction only 18976650 Common - hypothetical protein PF0278 17 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 18977668 Common - dihydropteroate synthase PF1296 216 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 18977183 Nonpathogen - hypothetical protein PF0811 2 None None None 18978040 Nonpathogen - hypothetical protein PF1668 3 None None None 18977308 Common - ketol-acid reductoisomerase PF0936 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 18977905 Common - nodulation protein nfeD PF1533 72 COG1030 NfeD, Membrane-bound serine protease (ClpP class) Posttranslational modification, protein turnover, chaperones 18977513 Nonpathogen - H/ACA RNA-protein complex component Nop10p PF1141 24 COG2260 COG2260, Predicted Zn-ribbon RNA-binding protein Translation, ribosomal structure and biogenesis 18976562 Common - hypothetical protein PF0190 15 COG3889 COG3889, Predicted solute binding protein General function prediction only 18978436 Common - arylsulfatase regulatory protein, putative PF2064 117 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 18976836 Common - glyceraldehyde-3-phosphate:ferredoxin oxidoreductase PF0464 43 COG2414 COG2414, Aldehyde:ferredoxin oxidoreductase Energy production and conversion 18976489 Common - putative sugar transport protein PF0117 150 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 18978316 Nonpathogen - hypothetical protein PF1944 2 None None None 18977295 Nonpathogen - hypothetical protein PF0923 1 None None None 18977659 Common - putative ABC transporter PF1287 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 18978210 Common - hypothetical protein PF1838 150 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 33359476 Nonpathogen - hypothetical protein PF0380 7 COG1475 Spo0J, Predicted transcriptional regulators Transcription 18976576 Common - hypothetical protein PF0204 179 COG0067 GltB, Glutamate synthase domain 1 Amino acid transport and metabolism 18977054 Nonpathogen - hypothetical protein PF0682 1 None None None 18977210 Common - hypothetical protein PF0838 4 COG5559 COG5559, Uncharacterized conserved small protein Function unknown 18977896 Nonpathogen - hypothetical protein PF1524 1 None None None 18978181 Common rps8p 30S ribosomal protein S8P PF1809 203 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 18977281 Common - hypothetical ferric enterobactin transport ATP-binding protein PF0909 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 18977853 Common - hypothetical protein PF1481 35 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 18976741 Common - putative endoglucanase PF0369 90 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 18976547 Common - trk system potassium uptake - like protein PF0175 176 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 33359469 Nonpathogen - hypothetical protein PF0329 2 COG3889 COG3889, Predicted solute binding protein General function prediction only 18976936 Common - ATP-dependent RNA helicase hepa, putative PF0564 160 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 18977173 Nonpathogen - hypothetical protein PF0801 1 None None None 18977650 Common - hypothetical protein PF1278 16 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 18976876 Common - DNA helicase PF0504 48 COG1444 COG1444, Predicted P-loop ATPase fused to an acetyltransferase General function prediction only 18976809 Nonpathogen - hypothetical protein PF0437 2 None None None 18977108 Nonpathogen - hypothetical protein PF0736 1 None None None 18977590 Nonpathogen - hypothetical protein PF1218 10 None None None 18977639 Common - hypothetical protein PF1267 37 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 18977723 Common - threonyl-tRNA synthetase PF1351 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 18976885 Common - 4-aminobutyrate aminotransferase PF0513 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 18978147 Common - putative small multidrug export protein PF1775 20 COG2426 COG2426, Predicted membrane protein Function unknown 18977752 Common argS arginyl-tRNA synthetase PF1380 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 18976406 Nonpathogen - hypothetical protein PF0034 1 None None None 18977646 Common - urea amidolyase PF1274 115 COG1984 DUR1, Allophanate hydrolase subunit 2 Amino acid transport and metabolism 18978229 Common - cobalt transport ATP-binding protein cbio PF1857 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 18978300 Common - ATP-binding protein phnp PF1928 71 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 18977095 Common - hypothetical protein PF0723 66 COG0672 FTR1, High-affinity Fe2+/Pb2+ permease Inorganic ion transport and metabolism 18978202 Nonpathogen - putative regulatory protein PF1830 2 None None None 18976846 Common - DNA mismatch repair protein PF0474 20 COG1193 COG1193, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 18977224 Common - hypothetical protein PF0852 135 COG2252 COG2252, Permeases General function prediction only 18976805 Nonpathogen - hypothetical Methyl-accepting chemotaxis related protein PF0433 1 None None None 18978164 Common - hypothetical 5'-cyclic-nucleotide phosphodiesterase cpda PF1792 87 COG0622 COG0622, Predicted phosphoesterase General function prediction only 18977396 Common cysS cysteinyl-tRNA synthetase PF1024 245 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 18976938 Common - hypothetical protein PF0566 35 COG1483 COG1483, Predicted ATPase (AAA+ superfamily) General function prediction only 18977689 Common - hypothetical protein PF1317 65 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 18977737 Common - hypothetical protein PF1365 17 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 18977533 Common - hypothetical protein PF1161 30 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 18976444 Nonpathogen - hypothetical protein PF0072 2 None None None 18977765 Common - hypothetical protein PF1393 35 COG1543 COG1543, Uncharacterized conserved protein Function unknown 18977140 Common - acetyl / acyl transferase related protein PF0768 208 COG1043 LpxA, Acyl- acyl carrier protein 18977675 Nonpathogen - hypothetical protein PF1303 3 COG4025 COG4025, Predicted membrane protein Function unknown 18977439 Nonpathogen - hypothetical protein PF1067 1 None None None 18978406 Nonpathogen - hypothetical protein PF2034 16 COG1590 COG1590, Uncharacterized conserved protein Function unknown 18977149 Nonpathogen - hypothetical protein PF0777 6 None None None 18977015 Nonpathogen - hypothetical protein PF0643 2 None None None 18977796 Common - putative monovalent cation/H+ antiporter subunit F PF1424 84 COG2212 MnhF, Multisubunit Na+/H+ antiporter, MnhF subunit Inorganic ion transport and metabolism 18976378 Common - hypothetical ABC transporter PF0006 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18977386 Nonpathogen - hypothetical protein PF1014 1 None None None 18976390 Nonpathogen - DNA polymerase II small subunit PF0018 24 COG1311 HYS2, Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B DNA replication, recombination, and repair 18978351 Common - hypothetical protein PF1979 78 COG2078 AMMECR1, Uncharacterized conserved protein Function unknown 18977778 Common - threonine synthase PF1406 214 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 18977261 Nonpathogen - hypothetical protein PF0889 1 None None None 18978132 Common - hypothetical protein PF1760 26 COG3199 COG3199, Uncharacterized conserved protein Function unknown 18977253 Common - putative ABC transporter PF0881 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18976662 Common valS valyl-tRNA synthetase PF0290 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 18976999 Nonpathogen - hypothetical protein PF0627 2 None None None 18976782 Nonpathogen - hypothetical protein PF0410 2 None None None 18977556 Common - hypothetical protein PF1184 51 COG1801 COG1801, Uncharacterized conserved protein Function unknown 18977217 Common - 2-keto acid:ferredoxin oxidoreductase subunit alpha PF0845 130 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 18978334 Nonpathogen - hypothetical protein PF1962 2 None None None 18977835 Nonpathogen - hypothetical protein PF1463 1 None None None 18978267 Nonpathogen - biotin synthetase PF1895 2 None None None 18978281 Common - ferredoxin PF1909 32 COG1141 Fer, Ferredoxin Energy production and conversion 18978002 Common - UDP-n-acetylglucosamine 2-epimerase PF1630 154 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 18977311 Common leuD 3-isopropylmalate dehydratase small subunit PF0939 214 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 18977197 Common - prolyl endopeptidase PF0825 117 COG1505 COG1505, Serine proteases of the peptidase family S9A Amino acid transport and metabolism 18976767 Common - oxetanocin-like protein PF0395 52 COG1896 COG1896, Predicted hydrolases of HD superfamily General function prediction only 18976794 Common - phosphoribosylamine--glycine ligase PF0422 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 18976678 Common - sua5 superfamily-related protein PF0306 242 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 18976983 Common - hypothetical protein PF0611 32 COG1415 COG1415, Uncharacterized conserved protein Function unknown 18977802 Common - putative monovalent cation/H+ antiporter subunit D PF1430 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 18976495 Nonpathogen - hypothetical protein PF0123 13 COG1255 COG1255, Uncharacterized protein conserved in archaea Function unknown 18977757 Common - DNA polymerase, bacteriophage-type PF1385 155 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 33359492 Common - hypothetical protein PF0612 15 COG3885 COG3885, Uncharacterized conserved protein Function unknown 18977517 Common - mrp/nbp35 family nucleotide-binding protein PF1145 237 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 18978180 Common rpl6p 50S ribosomal protein L6P PF1808 240 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 18977464 Nonpathogen - hypothetical protein PF1092 1 None None None 18976921 Common - hydrogenase expression/formation protein PF0549 109 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 18978376 Common glpK glycerol kinase PF2004 179 COG0554 GlpK, Glycerol kinase Energy production and conversion 18977448 Common - hypothetical TLDD protein PF1076 168 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 18977082 Nonpathogen - hypothetical protein PF0710 1 None None None 18976773 Nonpathogen - methyltransferase PF0401 2 None None None 18976853 Nonpathogen - translation initiation factor IF-2 subunit beta PF0481 34 COG1601 GCD7, Translation initiation factor 2, beta subunit (eIF-2beta)/eIF-5 N-terminal domain Translation, ribosomal structure and biogenesis 18977954 Nonpathogen - translation initiation factor IF-1A PF1582 34 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 18976726 Common - hypothetical protein PF0354 61 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 18977623 Common - hypothetical protein PF1251 17 COG1470 COG1470, Predicted membrane protein Function unknown 18977442 Common - hypothetical protein PF1070 17 COG1310 COG1310, Predicted metal-dependent protease of the PAD1/JAB1 superfamily General function prediction only 33359550 Nonpathogen - hypothetical protein PF1214.2n 1 None None None 18976630 Common - putative endonuclease IV PF0258 31 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 18976508 Nonpathogen - hypothetical protein PF0136 3 None None None 18976381 Common - hypothetical protein PF0009 215 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 33359559 Nonpathogen - hypothetical protein PF1320.1n 1 None None None 18976970 Common - aspartate carbamoyltransferase regulatory subunit PF0598 64 COG1781 PyrI, Aspartate carbamoyltransferase, regulatory subunit Nucleotide transport and metabolism 33359569 Nonpathogen - hypothetical protein PF1612.1n 2 None None None 18977549 Common - GTP-binding protein, gtp1/obg family PF1177 239 COG2262 HflX, GTPases General function prediction only 18978060 Common - transketolase N-terminal section PF1688 184 COG3959 COG3959, Transketolase, N-terminal subunit Carbohydrate transport and metabolism 18976807 Common - DEXX-box atpase PF0435 31 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 18978385 Nonpathogen - hypothetical protein PF2013 17 COG1967 COG1967, Predicted membrane protein Function unknown 18977284 Nonpathogen - hypothetical protein PF0912 1 None None None 18977021 Common - hypothetical protein PF0649 9 COG1510 COG1510, Predicted transcriptional regulators Transcription 18978277 Nonpathogen - putative protease PF1905 3 None None None 18976754 Nonpathogen - hypothetical prefoldin PF0382 29 COG1382 GimC, Prefoldin, chaperonin cofactor Posttranslational modification, protein turnover, chaperones 18976732 Common - oligopeptide ABC transporter PF0360 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 18977560 Common - pyruvate kinase PF1188 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 18977356 Nonpathogen - hypothetical protein PF0984 2 None None None 18976464 Common - replication factor C large subunit PF0092 203 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 18978243 Nonpathogen - N(2),N(2)-dimethylguanosine tRNA methyltransferase PF1871 38 COG1867 TRM1, N2,N2-dimethylguanosine tRNA methyltransferase Translation, ribosomal structure and biogenesis 18977113 Common - hypothetical protein PF0741 21 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 18976582 Nonpathogen - putative oxidative cyclase PF0210 16 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 18976865 Nonpathogen - hypothetical protein PF0493 26 COG2433 COG2433, Uncharacterized conserved protein Function unknown 18976637 Common - 2-amino-3-ketobutyrate coenzyme A ligase PF0265 190 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 33359501 Nonpathogen - hypothetical protein PF0731.1n 1 None None None 18977588 Common - hypothetical protein PF1216 107 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 18977506 Common - putative kinase PF1134 35 COG1936 COG1936, Predicted nucleotide kinase (related to CMP and AMP kinases) Nucleotide transport and metabolism 18976660 Common - hypothetical protein PF0288 155 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 18978024 Nonpathogen - hypothetical protein PF1652 1 None None None 18976995 Nonpathogen - hypothetical protein PF0623 1 None None None 18976632 Nonpathogen - hypothetical protein PF0260 29 COG2237 COG2237, Predicted membrane protein Function unknown 18977559 Nonpathogen - hypothetical protein PF1187 7 COG2441 COG2441, Predicted butyrate kinase Energy production and conversion 18977706 Common thiE thiamine-phosphate pyrophosphorylase PF1334 191 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 18977098 Nonpathogen - hypothetical protein PF0726 2 COG3439 COG3439, Uncharacterized conserved protein Function unknown 18976665 Common - putative aminotransferase PF0293 232 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 18978424 Common - putative regulatory protein PF2052 38 COG1694 MazG, Predicted pyrophosphatase General function prediction only 33359515 Nonpathogen - hypothetical protein PF0842.1n 2 None None None 18976558 Common - n-type ATP pyrophosphatase superfamily PF0186 39 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 18978325 Common - inosine-5'-monophosphate dehydrogenase related protein II PF1953 160 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 18977920 Nonpathogen - hypothetical protein PF1548 3 None None None 18976697 Nonpathogen - hypothetical protein PF0325 4 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 18976759 Common - putative carbohydrate-binding protein PF0387 12 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 18977833 Common - glutamyl-tRNA(Gln) amidotransferase subunit D PF1461 136 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 18976880 Common - integral membrane glycosyltransferase PF0508 18 COG5305 COG5305, Predicted membrane protein Function unknown 18978086 Common carB carbamoyl phosphate synthase large subunit PF1714 239 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 18977151 Nonpathogen - hypothetical protein PF0779 2 None None None 18978004 Common - hypothetical protein PF1632 23 COG1817 COG1817, Uncharacterized protein conserved in archaea Function unknown 18977571 Nonpathogen - hypothetical protein PF1199 8 COG1633 COG1633, Uncharacterized conserved protein Function unknown 18978092 Nonpathogen - hypothetical protein PF1720 1 None None None 18976588 Common maf Maf-like protein PF0216 196 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 18976825 Nonpathogen - hypothetical protein PF0453 2 None None None 18977193 Nonpathogen rpl34e 50S ribosomal protein L34e PF0821 16 COG2174 RPL34A, Ribosomal protein L34E Translation, ribosomal structure and biogenesis 18976958 Nonpathogen - hypothetical protein PF0586 1 None None None 18978227 Nonpathogen - putative transcription-associated protein TFIIS PF1855 33 COG1571 COG1571, Predicted DNA-binding protein containing a Zn-ribbon domain General function prediction only 18977530 Common - hypothetical protein PF1158 15 COG1856 COG1856, Uncharacterized homolog of biotin synthetase Function unknown 18977472 Nonpathogen - hypothetical protein PF1100 1 None None None 18977573 Nonpathogen - hypothetical protein PF1201 5 COG4072 COG4072, Uncharacterized protein conserved in archaea Function unknown 18977940 Common - exosome complex exonuclease Rrp41 PF1568 233 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 18978027 Common - hypothetical ABC transporter PF1655 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 33359544 Nonpathogen - hypothetical protein PF1123 7 None None None 18977081 Nonpathogen - hypothetical protein PF0709 2 COG2512 COG2512, Uncharacterized membrane-associated protein/domain Function unknown 18977069 Nonpathogen - multidrug resistance protein PF0697 5 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 18976524 Common - hypothetical protein PF0152 74 COG2013 COG2013, Uncharacterized conserved protein Function unknown 18977022 Nonpathogen - hypothetical protein PF0650 2 None None None 18977827 Nonpathogen - hypothetical protein PF1455 2 None None None 18976690 Common - hypothetical acylaminoacyl-peptidase PF0318 109 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 18978112 Common - trehalose/maltose transport inner membrane protein PF1740 193 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 18977123 Common - flavoprotein PF0751 83 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 18978108 Common - transposase PF1736 26 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18977426 Common - homoserine kinase PF1054 118 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 18976482 Nonpathogen - DNA primase small subunit PF0110 30 COG1467 PRI1, Eukaryotic-type DNA primase, catalytic (small) subunit DNA replication, recombination, and repair 18976620 Common - hypothetical protein PF0248 33 COG1839 COG1839, Uncharacterized conserved protein Function unknown 18977903 Common - thiamine biosynthesis protein ThiC PF1531 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 18977132 Common - hypothetical protein PF0760 43 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 33359570 Nonpathogen - hypothetical protein PF1666 11 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 18977801 Common - putative monovalent cation/H+ antiporter subunit C PF1429 78 COG1006 MnhC, Multisubunit Na+/H+ antiporter, MnhC subunit Inorganic ion transport and metabolism 18976446 Common - alcohol dehydrogenase, short chain PF0074 235 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 18977988 Common - myo-inositol-1-phosphate synthase PF1616 60 COG1260 INO1, Myo-inositol-1-phosphate synthase Lipid metabolism 18976657 Common - inositol-5-monophosphate dehydrogenase PF0285 243 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 18978119 Common - hypothetical protein PF1747 32 COG2152 COG2152, Predicted glycosylase Carbohydrate transport and metabolism 18977335 Common - cell division control protein 48, aaa family PF0963 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 18977771 Nonpathogen - putative ATPase, vanadate-sensitive PF1399 4 None None None 18976913 Common - methionine aminopeptidase PF0541 248 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 18977349 Common - hypothetical protein PF0977 49 COG2431 COG2431, Predicted membrane protein Function unknown 18977457 Common - hypothetical protein PF1085 143 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 18977139 Common - pleiotropic regulatory protein degT PF0767 195 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 18978153 Common rnhB ribonuclease HII PF1781 233 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 18976515 Common - quinolone resistance protein norA - like protein PF0143 139 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 33359575 Nonpathogen - hypothetical protein PF1828 2 COG2450 COG2450, Uncharacterized conserved protein Function unknown 18976859 Common - related to bacterial autolysins PF0487 11 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 18976452 Common - hypothetical protein PF0080 27 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 18978039 Common - partial methionyl-tRNA synthetase - matches COOH terminus PF1667 171 COG0073 ARC1, EMAP domain General function prediction only 18976900 Common - cobalt transport ATP-binding protein PF0528 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 18977031 Nonpathogen - hypothetical protein PF0659 2 None None None 18977393 Common - hypothetical protein PF1021 42 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 18978099 Nonpathogen - hypothetical protein PF1727 2 None None None 18977165 Nonpathogen - hypothetical protein PF0793 2 None None None 18977949 Nonpathogen - hypothetical protein PF1577 5 COG1771 COG1771, Uncharacterized protein conserved in archaea Function unknown 33359478 Nonpathogen - hypothetical transposase PF0429.1n 1 None None None 18977792 Nonpathogen - hypothetical protein PF1420 1 None None None 18976788 Nonpathogen - hypothetical protein PF0416 1 None None None 18976712 Nonpathogen - putative HTH transcription regulator PF0340 6 COG3373 COG3373, Uncharacterized protein conserved in archaea Function unknown 18977342 Common vorD 2-ketoisovalerate ferredoxin oxidoreductase subunit delta PF0970 80 COG1144 COG1144, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit Energy production and conversion 18977226 Nonpathogen - endo-1,4-beta-glucanase b PF0854 5 None None None 18977857 Nonpathogen - hypothetical protein PF1485 21 COG1849 COG1849, Uncharacterized protein conserved in archaea Function unknown 18977995 Nonpathogen - pyruvoyl-dependent arginine decarboxylase PF1623 17 COG1945 COG1945, Uncharacterized conserved protein Function unknown 18976629 Common - inorganic pyrophosphatase PF0257 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 18978030 Common hisG ATP phosphoribosyltransferase catalytic subunit PF1658 209 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 18978045 Common - protoporphyrinogen oxidase PF1673 193 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 18978176 Common rps5p 30S ribosomal protein S5P PF1804 249 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 18978311 Common - neopullulanase (alpha-amylase II) PF1939 161 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 18978067 Common - hypothetical lipoprotein PF1695 84 COG1744 Med, Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein General function prediction only 18976941 Nonpathogen - hypothetical protein PF0569 4 COG2028 COG2028, Uncharacterized conserved protein Function unknown 18976600 Nonpathogen - hypothetical protein PF0228 1 None None None 18976680 Common - adenylosuccinate synthetase PF0308 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 18977640 Common - 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase PF1268 57 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 18976439 Common - cobalt transport ABC transporter, integral membrane component PF0067 43 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 18978391 Nonpathogen - hypothetical protein PF2019 2 None None None 18977544 Common - RNA methyltransferase PF1172 203 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 33359466 Nonpathogen - hypothetical protein PF0298.1n 2 None None None 18976403 Common - threonine synthase PF0031 218 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 18976905 Common - indolepyruvate ferredoxin oxidoreductase subunit a PF0533 111 COG4231 COG4231, Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits Energy production and conversion 18976432 Nonpathogen - NOP5/NOP56 related protein PF0060 34 COG1498 SIK1, Protein implicated in ribosomal biogenesis, Nop56p homolog Translation, ribosomal structure and biogenesis 18978073 Common - chorismate mutase PF1701 42 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 18977406 Common pyrE orotate phosphoribosyltransferase PF1034 241 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 18977304 Nonpathogen - hypothetical protein PF0932 2 None None None 18977606 Common - putative chitinase PF1234 39 COG3325 ChiA, Chitinase Carbohydrate transport and metabolism 18977049 Common - ski2-like helicase PF0677 196 COG1204 COG1204, Superfamily II helicase General function prediction only 161484706 Common - CTP synthetase PF1839 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 18978415 Common - hypothetical protein PF2043 30 COG2962 RarD, Predicted permeases General function prediction only 18977636 Nonpathogen - translation initiation factor IF-5A PF1264 35 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 18977981 Common - hypothetical protein PF1609 29 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 18977721 Common - translation initiation factor IF-2B subunit beta PF1349 131 COG0182 COG0182, Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 18976578 Common - hypothetical protein PF0206 118 COG0070 GltB, Glutamate synthase domain 3 Amino acid transport and metabolism 18977809 Common - hypothetical protein PF1437 40 COG4027 COG4027, Uncharacterized protein conserved in archaea Function unknown 18977306 Nonpathogen - hypothetical protein PF0934 2 None None None 18977726 Common - putative oligosaccharide transporter PF1354 70 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 18977215 Common - hypothetical protein PF0843 105 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 18976541 Common - putative nol1-nop2-sun family nucleolar protein III PF0169 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 18976800 Common - partial alanyl-tRNA synthetase matches COOH terminus PF0428 141 COG2872 COG2872, Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain General function prediction only 18976652 Nonpathogen - hypothetical protein PF0280 1 None None None 18978318 Common - methylmalonyl-CoAmutase, subunit alpha PF1946 107 COG2185 Sbm, Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) Lipid metabolism 18976535 Nonpathogen - hypothetical protein PF0163 3 COG3601 COG3601, Predicted membrane protein Function unknown 18976748 Nonpathogen rplX 50S ribosomal protein LX PF0376 17 COG2157 RPL20A, Ribosomal protein L20A (L18A) Translation, ribosomal structure and biogenesis 18977205 Nonpathogen - low temperature requirement C - like protein PF0833 11 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 18977657 Common - hypothetical protein PF1285 112 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 18977106 Nonpathogen - hypothetical protein PF0734 1 None None None 18977450 Nonpathogen - hypothetical protein PF1078 5 COG1906 COG1906, Uncharacterized conserved protein Function unknown 18976931 Common - hydrogenase expression/formation regulatory protein PF0559 129 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 33359464 Nonpathogen - putative HTH transcription regulator PF0247 2 COG1522 Lrp, Transcriptional regulators Transcription 18976373 Common - hypothetical protein PF0001 58 COG0778 NfnB, Nitroreductase Energy production and conversion 18977413 Common - hypothetical protein PF1041 38 COG1855 COG1855, ATPase (PilT family) General function prediction only 18977372 Common - oligopeptide transport system permease protein appc PF1000 196 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 18978183 Common rpl5p 50S ribosomal protein L5P PF1811 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 18977297 Common - heme biosynthesis protein PF0925 82 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 33359474 Nonpathogen - hypothetical protein PF0355.1n 3 None None None 18977686 Common - hypothetical protein PF1314 15 COG1432 COG1432, Uncharacterized conserved protein Function unknown 18977043 Common - methylmalonyl-CoAdecarboxylase, subunit alpha PF0671 218 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 18976622 Common - transcriptional regulatory protein, lrp family PF0250 169 COG1522 Lrp, Transcriptional regulators Transcription 18978353 Nonpathogen - hypothetical protein PF1981 12 COG2413 COG2413, Predicted nucleotidyltransferase General function prediction only 18977607 Common ccrB camphor resistance protein CrcB PF1235 143 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 18976422 Nonpathogen - DNA-directed RNA polymerase subunit L PF0050 17 COG1761 RPB11, DNA-directed RNA polymerase, subunit L Transcription 18977244 Nonpathogen - hypothetical protein PF0872 16 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 18977330 Common - hypothetical protein PF0958 16 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 18977121 Nonpathogen - hypothetical protein PF0749 2 None None None 18978366 Nonpathogen rpl12p 50S ribosomal protein L12P PF1994 33 COG2058 RPP1A, Ribosomal protein L12E/L44/L45/RPP1/RPP2 Translation, ribosomal structure and biogenesis 18978265 Common - transcriptional regulatory protein, asnC family PF1893 11 COG1522 Lrp, Transcriptional regulators Transcription 18977929 Common - hypothetical protein PF1557 64 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 18977930 Common - 30S ribosomal protein S7P PF1558 37 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 18978113 Common - trehalose/maltose transport inner membrane protein PF1741 168 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 18977696 Nonpathogen - hypothetical protein PF1324 2 None None None 18977665 Common - prolyl-tRNA synthetase PF1293 249 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 18978307 Common - amylopullulanase PF1935 34 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 18978235 Common ksgA dimethyladenosine transferase PF1863 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 33359482 Common - hypothetical protein PF0449 56 COG0679 COG0679, Predicted permeases General function prediction only 18977490 Common - hypothetical protein PF1118 91 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 33359447 Nonpathogen - DNA polymerase II large subunit PF0019 25 COG1933 COG1933, Archaeal DNA polymerase II, large subunit DNA replication, recombination, and repair 33359459 Nonpathogen - hypothetical protein PF0222.1n 2 None None None 18976454 Common - membrane protein PF0082 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 33359587 Nonpathogen - hypothetical protein PF2000.1n 1 None None None 18977910 Common - N-ethylammeline chlorohydrolase PF1538 186 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 18977763 Nonpathogen - hypothetical protein PF1391 2 None None None 18977076 Common - hypothetical protein PF0704 20 COG3439 COG3439, Uncharacterized conserved protein Function unknown 18977437 Common - hypothetical protein PF1065 92 COG0327 COG0327, Uncharacterized conserved protein Function unknown 18977535 Nonpathogen - hypothetical protein PF1163 10 COG2034 COG2034, Predicted membrane protein Function unknown 18977483 Common - hypothetical protein PF1111 18 COG1568 COG1568, Predicted methyltransferases General function prediction only 18977869 Common - alanine aminotransferase PF1497 239 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 18977600 Common - hypothetical protein PF1228 116 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 18978255 Common - small heat shock protein PF1883 164 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 18977274 Nonpathogen - hypothetical protein PF0902 1 None None None 18977880 Nonpathogen - hypothetical protein PF1508 2 None None None 18977618 Common - sarcosine oxidase, subunit beta PF1246 151 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 18976416 Nonpathogen - hypothetical protein PF0044 3 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 18977326 Nonpathogen - hypothetical protein PF0954 1 None None None 18977831 Nonpathogen - hypothetical protein PF1459 7 COG2407 FucI, L-fucose isomerase and related proteins Carbohydrate transport and metabolism 18976695 Nonpathogen - hypothetical protein PF0323 3 None None None 18978270 Nonpathogen - hypothetical protein PF1898 9 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 18978128 Common - hypothetical protein PF1756 107 COG0393 COG0393, Uncharacterized conserved protein Function unknown 18976997 Common - hypothetical protein PF0625 67 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 18977097 Common - hypothetical protein PF0725 103 COG1832 COG1832, Predicted CoA-binding protein General function prediction only 18978404 Common - hypothetical protein PF2032 51 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 18976407 Common - daunorubicin resistance ATP-binding protein PF0035 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18978332 Common - aldose reductase PF1960 198 COG0656 ARA1, Aldo/keto reductases, related to diketogulonate reductase General function prediction only 18976875 Common - putative iron ABC transporter PF0503 191 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 18977384 Common - putative ABC transporter PF1012 127 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 18976882 Common - mazg beta-lactamase regulatory protein - like protein PF0510 18 COG1694 MazG, Predicted pyrophosphatase General function prediction only 18977565 Common - hypothetical protein PF1193 19 COG2406 COG2406, Protein distantly related to bacterial ferritins General function prediction only 33359499 Nonpathogen - hypothetical protein PF0687.2n 1 None None None 18978190 Nonpathogen rpmC 50S ribosomal protein L29 PF1818 3 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 18977918 Nonpathogen - hypothetical protein PF1546 1 None None None 18977254 Nonpathogen - hypothetical protein PF0882 2 None None None 18977818 Common - NADH dehydrogenase subunit M PF1446 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 33359490 Common - transposase PF0605 10 None None None 18977497 Common - hypothetical protein PF1125 8 COG3337 COG3337, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 18978130 Common - n-type ATP pyrophosphatase superfamily PF1758 172 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 18977195 Common - hypothetical protein PF0823 182 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 18976536 Common - nifS protein PF0164 242 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 18976796 Nonpathogen - hypothetical protein PF0424 2 None None None 18976685 Nonpathogen - signal sequence peptidase I PF0313 2 None None None 18977716 Common - putative maleate cis-trans isomerase PF1344 47 COG3473 COG3473, Maleate cis-trans isomerase Secondary metabolites biosynthesis, transport, and catabolism 18976981 Nonpathogen - hypothetical protein PF0609 3 None None None 33359560 Nonpathogen - hypothetical protein PF1342 1 None None None 18976823 Nonpathogen - hypothetical protein PF0451 2 None None None 18977630 Common - ribose-5-phosphate isomerase A PF1258 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 18978283 Common - ferredoxin--NADP(+) reductase subunit alpha PF1911 62 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 18977759 Nonpathogen - hypothetical protein PF1387 30 COG1701 COG1701, Uncharacterized protein conserved in archaea Function unknown 18977017 Nonpathogen - hypothetical protein PF0645 4 None None None 18976676 Common - DEXX-box atpase PF0304 34 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 33359525 Nonpathogen - N-glycosylase/DNA lyase PF0904 12 COG4047 COG4047, Uncharacterized protein conserved in archaea Function unknown 18977798 Nonpathogen - hypothetical protein PF1426 2 COG1563 COG1563, Predicted subunit of the Multisubunit Na+/H+ antiporter Inorganic ion transport and metabolism 18977851 Common - putative oxidoreductase, Fe-S subunit PF1479 142 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 18978199 Common - hypothetical protein PF1827 165 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 18978279 Nonpathogen - hypothetical protein PF1907 1 None None None 18977519 Common - putative monovalent cation/H+ antiporter subunit D PF1147 210 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 18977894 Common - putative ABC transporter PF1522 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18976720 Common - transposase PF0348 25 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 33359527 Nonpathogen - hypothetical protein PF0927 15 COG1412 COG1412, Uncharacterized proteins of PilT N-term./Vapc superfamily General function prediction only 18977735 Common - glycosyl transferase PF1363 139 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 18976595 Nonpathogen - hypothetical protein PF0223 3 None None None 18978434 Nonpathogen - hypothetical protein PF2062 2 COG2512 COG2512, Uncharacterized membrane-associated protein/domain Function unknown 33359535 Nonpathogen - sulfur carrier protein ThiS PF1061 9 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 18977515 Common panB 3-methyl-2-oxobutanoate hydroxymethyltransferase PF1143 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 18978012 Common rps2P 30S ribosomal protein S2 PF1640 171 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 18977637 Common - putative nol1-nop2-sun family nucleolar protein II PF1265 209 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 18976397 Nonpathogen - hypothetical protein PF0025 11 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 18978048 Common - biotin operon repressor/biotin--[acetyl CoA carboxylase] ligase PF1676 186 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 18977625 Common - aspartate aminotransferase PF1253 241 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 161484710 Common - putative monovalent cation/H+ antiporter subunit G PF1151 69 COG1320 MnhG, Multisubunit Na+/H+ antiporter, MnhG subunit Inorganic ion transport and metabolism 18977144 Common - hypothetical protein PF0772 17 COG1708 COG1708, Predicted nucleotidyltransferases General function prediction only 18978302 Common - S-adenosylmethionine decarboxylase proenzyme PF1930 73 COG1586 SpeD, S-adenosylmethionine decarboxylase Amino acid transport and metabolism 18978204 Common - regulatory protein PF1832 76 COG1469 COG1469, Uncharacterized conserved protein Function unknown 18977858 Nonpathogen - hypothetical protein PF1486 18 COG1885 COG1885, Uncharacterized protein conserved in archaea Function unknown 18978379 Common - hypothetical protein PF2007 14 COG3862 COG3862, Uncharacterized protein with conserved CXXC pairs Function unknown 18977595 Common - hypothetical protein PF1223 11 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 18977673 Common - hypothetical protein PF1301 217 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 18978297 Common - hypothetical protein PF1925 29 COG1818 COG1818, Predicted RNA-binding protein, contains THUMP domain General function prediction only 18976516 Common - hypothetical protein PF0144 72 COG2516 COG2516, Biotin synthase-related enzyme General function prediction only 18978220 Common - 3-hydroxy-3-methylglutaryl-coenzyme a reductase (hmg-CoAreductase) PF1848 69 COG1257 HMG1, Hydroxymethylglutaryl-CoA reductase Lipid metabolism 18978290 Common - hypothetical protein PF1918 61 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 18977887 Common - GMP synthase subunit A PF1515 241 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 18976815 Common - putative membrane transport protein PF0443 196 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 18978321 Nonpathogen - hypothetical protein PF1949 2 None None None 18977593 Common - dissimilatory sulfate adenylyltransferase PF1221 59 COG2046 MET3, ATP sulfurylase (sulfate adenylyltransferase) Inorganic ion transport and metabolism 18978146 Common - iron III ABC transporter, ATP-binding protein PF1774 182 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 18976944 Common - dna2-nam7 helicase family protein PF0572 86 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 18977362 Common pheT phenylalanyl-tRNA synthetase subunit beta PF0990 242 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 18977271 Nonpathogen - hypothetical protein PF0899 2 None None None 18978150 Common glyA serine hydroxymethyltransferase PF1778 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 18976477 Nonpathogen - hypothetical protein PF0105 2 None None None 18976641 Nonpathogen - hypothetical protein PF0269 2 None None None 18977608 Common - hypothetical protein PF1236 52 COG1993 COG1993, Uncharacterized conserved protein Function unknown 18976520 Nonpathogen - hypothetical protein PF0148 8 COG3371 COG3371, Predicted membrane protein Function unknown 18977886 Nonpathogen - hypothetical protein PF1514 1 None None None 18977301 Nonpathogen - hypothetical protein PF0929 2 None None None 18976425 Common - putative ATP dependent RNA helicase PF0053 205 COG1202 COG1202, Superfamily II helicase, archaea-specific General function prediction only 18977784 Common - dipeptide transport ATP-binding protein PF1412 249 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 18977935 Common - DNA-directed RNA polymerase subunit alpha PF1563 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 18977444 Common - hypothetical protein PF1072 27 COG4189 COG4189, Predicted transcriptional regulator Transcription 18977522 Nonpathogen - putative monovalent cation/H+ antiporter subunit B PF1150 2 COG2111 MnhB, Multisubunit Na+/H+ antiporter, MnhB subunit Inorganic ion transport and metabolism 18978230 Common - cysteine synthase PF1858 221 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 18978173 Common - preprotein translocase subunit SecY PF1801 139 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 18976926 Common - hypothetical protein PF0554 173 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 18977089 Common - putative methyltransferase PF0717 66 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 18978260 Common - hypothetical protein PF1888 158 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 18976669 Nonpathogen - hypothetical protein PF0297 2 None None None 18977100 Common - hypothetical protein PF0728 42 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 18976886 Common - d-alanine glycine permease PF0514 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 18977133 Nonpathogen - hypothetical protein PF0761 5 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 33359520 Nonpathogen - hypothetical protein PF0876.1n 1 None None None 18978075 Common - prephenate dehydrogenase PF1703 5 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 18977845 Nonpathogen - hypothetical protein PF1473 10 COG2112 COG2112, Predicted Ser/Thr protein kinase Signal transduction mechanisms 18978011 Common - threonine synthase PF1639 213 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 18976601 Nonpathogen - hypothetical protein PF0229 1 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 18977369 Nonpathogen - hypothetical protein PF0997 4 None None None 18977042 Common - putative ATPase RIL PF0670 249 COG1245 COG1245, Predicted ATPase, RNase L inhibitor (RLI) homolog General function prediction only 18976414 Common - metal-dependent hydrolase PF0042 34 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 18977567 Common - hypothetical protein PF1195 10 COG1633 COG1633, Uncharacterized conserved protein Function unknown 33359468 Common - hypothetical protein PF0326 17 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 18976684 Nonpathogen - ADP-specific phosphofructokinase PF0312 8 COG4809 COG4809, Archaeal ADP-dependent phosphofructokinase/glucokinase Carbohydrate transport and metabolism 18977848 Common - hypothetical protein PF1476 13 COG1695 COG1695, Predicted transcriptional regulators Transcription 18976976 Common - hydrogenase expression/formation protein PF0604 203 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 18977761 Common - hypothetical protein PF1389 107 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 18976420 Common - succinoglycan biosynthesis regulator PF0048 176 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 18977007 Common - DEXX-box atpase PF0635 29 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 18977901 Common - pyridoxine biosynthesis protein PF1529 87 COG0214 SNZ1, Pyridoxine biosynthesis enzyme Coenzyme metabolism 18977236 Nonpathogen - transcriptional regulatory protein, asnC family PF0864 5 COG1522 Lrp, Transcriptional regulators Transcription 33359498 Nonpathogen - hypothetical protein PF0687.1n 1 None None None 18977323 Nonpathogen - hypothetical protein PF0951 1 None None None 18976730 Common - oppbc family ABC transporter PF0358 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 18978416 Common - glycogen synthase PF2044 204 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 18976966 Common - ornithine carbamoyltransferase PF0594 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 18976955 Common - daunorubicin resistance ATP-binding protein PF0583 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 33359578 Nonpathogen - hypothetical protein PF1867 5 COG4026 COG4026, Uncharacterized protein containing TOPRIM domain, potential nuclease General function prediction only 18978184 Nonpathogen - 30S ribosomal protein S4e PF1812 34 COG1471 RPS4A, Ribosomal protein S4E Translation, ribosomal structure and biogenesis 18977383 Common - daunorubicin resistance ATP-binding protein drrA PF1011 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18976503 Nonpathogen - hypothetical protein PF0131 3 COG5608 COG5608, Conserved secreted protein Function unknown 18977037 Nonpathogen - hypothetical protein PF0665 1 None None None 18977586 Nonpathogen nusA transcription elongation factor NusA-like protein PF1214 19 COG0195 NusA, Transcription elongation factor Transcription 18977332 Nonpathogen - hypothetical protein PF0960 1 COG4607 CeuA, ABC-type enterochelin transport system, periplasmic component Inorganic ion transport and metabolism 18977978 Common - dolichol-phosphate mannose synthase PF1606 227 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 18977434 Common - hypothetical protein PF1062 30 COG3269 COG3269, Predicted RNA-binding protein, contains TRAM domain General function prediction only 18976719 Nonpathogen - hypothetical protein PF0347 2 None None None 18978429 Nonpathogen - hypothetical protein PF2057 3 None None None 18977191 Nonpathogen - 50S ribosomal protein L14e PF0819 19 COG2163 RPL14A, Ribosomal protein L14E/L6E/L27E Translation, ribosomal structure and biogenesis 18978061 Common - transketolase C-terminal section PF1689 230 COG3958 COG3958, Transketolase, C-terminal subunit Carbohydrate transport and metabolism 18976708 Nonpathogen - hypothetical protein PF0336 6 COG3352 FlaC, Putative archaeal flagellar protein C Cell motility and secretion 18976854 Nonpathogen - cell division control protein 21 PF0482 36 COG1241 MCM2, Predicted ATPase involved in replication control, Cdc46/Mcm family DNA replication, recombination, and repair 18978422 Nonpathogen - hypothetical protein PF2050 4 None None None 18978237 Nonpathogen - putative regulatory protein PF1865 5 None None None 18977679 Nonpathogen - hypothetical protein PF1307 1 None None None 18977601 Common - glycosylase putative; mutY-nth family PF1229 239 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 18978177 Common rpl18p 50S ribosomal protein L18P PF1805 37 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 18976560 Common - dihydroorotate dehydrogenase electron transfer subunit PF0188 84 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 18976626 Nonpathogen - hypothetical protein PF0254 31 COG1909 COG1909, Uncharacterized protein conserved in archaea Function unknown 18977674 Nonpathogen - hypothetical protein PF1302 4 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 18978395 Common - DNA invertase PF2023 34 COG2452 COG2452, Predicted site-specific integrase-resolvase DNA replication, recombination, and repair 18976840 Nonpathogen - hypothetical protein PF0468 16 COG1310 COG1310, Predicted metal-dependent protease of the PAD1/JAB1 superfamily General function prediction only 18976569 Common - phosphoribosylformylglycinamidine synthase subunit PurS PF0197 70 COG1828 PurS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component Nucleotide transport and metabolism 18977503 Nonpathogen - hypothetical protein PF1131 23 COG1583 COG1583, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 33359514 Common - hypothetical protein PF0841.1n 9 COG1637 COG1637, Predicted nuclease of the RecB family DNA replication, recombination, and repair 18976613 Common - tryptophanyl-tRNA synthetase PF0241 98 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 18978349 Common - quinolinate synthetase PF1977 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 18977964 Common - tryptophan synthase subunit beta PF1592 226 COG1350 COG1350, Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) General function prediction only 18977102 Nonpathogen - hypothetical protein PF0730 2 None None None 18976786 Nonpathogen - hypothetical protein PF0414 1 None None None 18978431 Common - putative aminopeptidase PF2059 67 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 18976627 Nonpathogen - DNA-directed RNA polymerase subunit E'' PF0255 34 COG2093 COG2093, DNA-directed RNA polymerase, subunit E'' Transcription 18977454 Nonpathogen - hypothetical protein PF1082 1 None None None 18978306 Nonpathogen - hypothetical protein PF1934 2 COG3889 COG3889, Predicted solute binding protein General function prediction only 18977474 Common - bifunctional short chain isoprenyl diphosphate synthase PF1102 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 18976526 Common - amidophosphoribosyltransferase PF0154 239 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 18977109 Nonpathogen - hypothetical protein PF0737 1 COG3462 COG3462, Predicted membrane protein Function unknown 18977626 Common - putative sodium dependent transporter PF1254 88 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 18978098 Nonpathogen - hypothetical protein PF1726 2 None None None 18977460 Common - hypothetical protein PF1088 17 COG1846 MarR, Transcriptional regulators Transcription 18977572 Common - transposase PF1200 15 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18976384 Common - hypothetical protein PF0012 39 COG1637 COG1637, Predicted nuclease of the RecB family DNA replication, recombination, and repair 18976822 Common - glutamine synthetase i PF0450 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 33359531 Common - frxA PF0975 22 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 18976775 Nonpathogen - hypothetical protein PF0403 1 None None None 18977071 Nonpathogen - hypothetical protein PF0699 1 None None None 18978007 Common - ATP-dependent DNA ligase PF1635 112 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 18977703 Common - H-II delta (hydrogenase subunit delta) PF1331 36 COG1941 FrhG, Coenzyme F420-reducing hydrogenase, gamma subunit Energy production and conversion 18978387 Common - ATP-dependent RNA helicase, putative PF2015 205 COG1111 MPH1, ERCC4-like helicases DNA replication, recombination, and repair 18978386 Common - bifunctional inositol-1 monophosphatase/fructose-1,6-bisphosphatase PF2014 210 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 18976781 Nonpathogen - hypothetical protein PF0409 3 None None None 18976812 Common - ribonucleotide-diphosphate reductase subunit alpha PF0440 233 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 18976653 Nonpathogen - hypothetical protein PF0281 6 None None None 18977584 Common - putative peptide ABC uptake protein PF1212 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 18977343 Common - pyruvate ferredoxin oxidoreductase subunit gamma PF0971 65 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 18977874 Nonpathogen - hypothetical protein PF1502 2 COG1470 COG1470, Predicted membrane protein Function unknown 18977424 Common - aspartate kinase PF1052 233 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 18976755 Nonpathogen - hypothetical protein PF0383 2 None None None 18976463 Nonpathogen - hypothetical protein PF0091 5 COG1575 MenA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase Coenzyme metabolism 18977546 Nonpathogen - hypothetical protein PF1174 2 COG2886 COG2886, Uncharacterized small protein Function unknown 18976643 Nonpathogen - hypothetical protein PF0271 2 None None None 18977469 Common - hypothetical protein PF1097 23 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 18978139 Common - 2-keto acid:ferredoxin oxidoreductase subunit delta PF1767 56 COG1146 COG1146, Ferredoxin Energy production and conversion 18977286 Nonpathogen - hypothetical protein PF0914 1 COG2191 COG2191, Formylmethanofuran dehydrogenase subunit E Energy production and conversion 18976874 Common - iron(III) dicitrate transport system permease protein fece PF0502 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 18977153 Nonpathogen - hypothetical protein PF0781 3 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 18977531 Common - group II decarboxylase PF1159 127 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 18976892 Common - hypothetical protein PF0520 32 None None None 18977923 Common - hypothetical protein PF1551 34 COG1379 COG1379, Uncharacterized conserved protein Function unknown 18978340 Common - sugar transport membrane protein PF1968 171 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 18978022 Common rps13p 30S ribosomal protein S13P PF1650 164 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 33359503 Nonpathogen - hypothetical protein PF0736.1n 1 None None None 18976433 Common - riboflavin synthase subunit alpha PF0061 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 33359553 Common - transposase PF1248 10 None None None 18976980 Common - alcohol dehydrogenase PF0608 173 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 18977264 Common - cytochrome-c3 hydrogenase subunit gamma PF0892 170 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 18976710 Nonpathogen - flagellin PF0338 6 COG1681 FlaB, Archaeal flagellins Cell motility and secretion 18978249 Common - thiamine monophosphate kinase PF1877 203 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 18978046 Common - hypothetical protein PF1674 33 COG2453 CDC14, Predicted protein-tyrosine phosphatase Signal transduction mechanisms 18976492 Nonpathogen - hypothetical protein PF0120 4 None None None 18977633 Nonpathogen - hypothetical protein PF1261 4 COG1409 Icc, Predicted phosphohydrolases General function prediction only 18978304 Nonpathogen - hypothetical protein PF1932 13 COG1318 COG1318, Predicted transcriptional regulators Transcription 18978319 Common - hypothetical protein PF1947 101 COG1703 ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family Amino acid transport and metabolism 18976764 Common - metalloprotease PF0392 39 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 18977127 Common - non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase PF0755 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 18976431 Nonpathogen - fibrillarin PF0059 34 COG1889 NOP1, Fibrillarin-like rRNA methylase Translation, ribosomal structure and biogenesis 18977832 Common - hypothetical protein PF1460 48 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 18977663 Common - hypothetical protein PF1291 32 COG0639 ApaH, Diadenosine tetraphosphatase and related serine/threonine protein phosphatases Signal transduction mechanisms 18976440 Common - cobalt transport ATP-binding protein PF0068 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 18977921 Common - RNA 3'-terminal-phosphate cyclase PF1549 47 COG0430 RCL1, RNA 3'-terminal phosphate cyclase RNA processing and modification 18976598 Common - hypothetical protein PF0226 10 COG0456 RimI, Acetyltransferases General function prediction only 18977318 Common - transposase PF0946 25 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18978136 Common - metal-dependent hydrolase PF1764 138 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 18976694 Common - nickel responsive regulator PF0322 67 COG0864 NikR, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain Transcription 18977662 Nonpathogen - hypothetical protein PF1290 3 COG5418 COG5418, Predicted secreted protein Function unknown 18977178 Nonpathogen - hypothetical protein PF0806 8 None None None 18976666 Nonpathogen - low temperature requirement C - like protein PF0294 13 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 18977705 Common - phosphomethylpyrimidine kinase PF1333 223 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 18977826 Common - hypothetical protein PF1454 165 COG1964 COG1964, Predicted Fe-S oxidoreductases General function prediction only 18976531 Common - multicatalytic endopeptidase complex beta subunit PF0159 36 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 18976394 Common - putative RNase E PF0022 34 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 18977090 Nonpathogen - hypothetical protein PF0718 3 None None None 18978143 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit alpha PF1771 115 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 18978206 Nonpathogen - hypothetical protein PF1834 9 COG3371 COG3371, Predicted membrane protein Function unknown 18977389 Common - hypothetical protein PF1017 206 COG0388 COG0388, Predicted amidohydrolase General function prediction only 18978160 Common - NDP-sugar dehydratase or epimerase PF1788 235 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 18977379 Common - phosphate transport system permease psta PF1007 227 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 18977713 Common gcvT glycine cleavage system aminomethyltransferase T PF1341 178 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 18977732 Common - hypothetical protein PF1360 104 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 18978295 Common - hypothetical protein PF1923 6 COG3273 COG3273, Uncharacterized conserved protein Function unknown 33359538 Nonpathogen - hypothetical protein PF1089 1 None None None 18977382 Common - phosphate ABC transporter, regulatory protein PF1010 146 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 18977404 Nonpathogen - hypothetical protein PF1032 33 COG1499 NMD3, NMD protein affecting ribosome stability and mRNA decay Translation, ribosomal structure and biogenesis 18977162 Nonpathogen - hypothetical protein PF0790 5 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 18977943 Nonpathogen - proteasome subunit alpha PF1571 34 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 18977616 Nonpathogen - hypothetical protein PF1244 2 None None None 18976790 Common - methanol dehydrogenase regulatory protein PF0418 192 COG0714 COG0714, MoxR-like ATPases General function prediction only 33359496 Nonpathogen - hypothetical protein PF0655.1n 1 None None None 18976742 Common - 2-hydroxyacid dehydrogenase PF0370 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 18978314 Common - hypothetical protein PF1942 59 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 18977004 Common - hypothetical protein PF0632 26 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 18976401 Nonpathogen - hypothetical protein PF0029 4 None None None 18976987 Common hypA hydrogenase nickel incorporation protein PF0615 25 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 18977839 Common - putative ABC transporter PF1467 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18978126 Common - fumarate hydratase PF1754 148 COG1838 FumA, Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain Energy production and conversion 18976915 Common - molybdopterin converting factor, subunit 1 PF0543 52 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 18977321 Nonpathogen - hypothetical protein PF0949 1 None None None 18978106 Common - transcriptional regulatory protein, asnC family PF1734 156 COG1522 Lrp, Transcriptional regulators Transcription 18976447 Common - alcohol dehydrogenase PF0075 173 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 18977337 Common - pyruvate ferredoxin oxidoreductase subunit beta PF0965 103 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 18976961 Common - mannose-6-phosphate isomerase/mannose-1-phosphate guanylyl transferase PF0589 165 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 18978397 Common - hypothetical protein PF2025 27 COG1433 COG1433, Uncharacterized conserved protein Function unknown 18976674 Common - co-factor modifying protein PF0302 57 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 18977010 Nonpathogen - hypothetical protein PF0638 2 None None None 18976922 Common - NADH oxidase PF0550 51 COG0778 NfnB, Nitroreductase Energy production and conversion 18978197 Common rpl3p 50S ribosomal protein L3P PF1825 92 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 18976571 Common - phosphoribosylformylglycinamidine synthase II PF0199 235 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 18978165 Nonpathogen - hypothetical protein PF1793 3 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 18977916 Nonpathogen - hypothetical protein PF1544 3 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 18977718 Common - pheromone shutdown protein PF1346 37 COG1916 COG1916, Uncharacterized homolog of PrgY (pheromone shutdown protein) Function unknown 18977538 Common - exonuclease putative PF1166 115 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 18976499 Common speE spermidine synthase PF0127 118 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 18978338 Common - hypothetical protein PF1966 23 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 18976777 Common - methanol dehydrogenase regulatory protein PF0405 179 COG0714 COG0714, MoxR-like ATPases General function prediction only 33359529 Nonpathogen - hypothetical protein PF0958.3n 1 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 18977257 Common - hypothetical protein PF0885 41 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 18978377 Common - glycerol-3-phosphate dehydrogenase PF2005 129 COG0579 COG0579, Predicted dehydrogenase General function prediction only 18977104 Common - daunorubicin resistance ATP-binding protein PF0732 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18977087 Common - NAD(P)H oxidase PF0715 124 COG0778 NfnB, Nitroreductase Energy production and conversion 18978070 Common - putative ribose ABC transporter PF1698 108 COG1079 COG1079, Uncharacterized ABC-type transport system, permease component General function prediction only 18977817 Common - NADH dehydrogenase subunit PF1445 191 COG0650 HyfC, Formate hydrogenlyase subunit 4 Energy production and conversion 33359453 Nonpathogen - hypothetical protein PF0131.3n 3 None None None 18976457 Common - putative DNA helicase PF0085 18 COG2251 COG2251, Predicted nuclease (RecB family) General function prediction only 18977467 Nonpathogen - hypothetical protein PF1095 1 None None None 18976849 Common - cytoplasmic alpha-amylase PF0477 40 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 18977627 Nonpathogen - hypothetical protein PF1255 1 None None None 33359461 Nonpathogen - hypothetical protein PF0237 26 COG4089 COG4089, Predicted membrane protein Function unknown 18976470 Common nadE NAD synthetase PF0098 217 COG0171 NadE, NAD synthase Coenzyme metabolism 18978360 Common - cell division protein FtsZ PF1988 233 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 18976395 Nonpathogen - hypothetical protein PF0023 2 None None None 18976833 Nonpathogen - tRNA 2'-O-methylase PF0461 31 COG1303 COG1303, Uncharacterized protein conserved in archaea Function unknown 18977061 Common - hypothetical protein PF0689 40 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 18977505 Nonpathogen - hypothetical protein PF1133 1 None None None 18977648 Nonpathogen - hypothetical protein PF1276 2 None None None 18977203 Common - hypothetical protein PF0831 27 COG3503 COG3503, Predicted membrane protein Function unknown 18978356 Nonpathogen - hypothetical protein PF1984 1 None None None 18977790 Nonpathogen - hypothetical protein PF1418 5 COG1689 COG1689, Uncharacterized protein conserved in archaea Function unknown 18976593 Nonpathogen - hypothetical protein PF0221 2 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 18977937 Nonpathogen rpoH DNA-directed RNA polymerase subunit H PF1565 28 COG2012 RPB5, DNA-directed RNA polymerase, subunit H, RpoH/RPB5 Transcription 33359546 Common - putative monovalent cation/H+ antiporter subunit C PF1148 16 COG1006 MnhC, Multisubunit Na+/H+ antiporter, MnhC subunit Inorganic ion transport and metabolism 18976802 Common purT phosphoribosylglycinamide formyltransferase 2 PF0430 211 COG0027 PurT, Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) Nucleotide transport and metabolism 18977485 Nonpathogen - hypothetical protein PF1113 6 None None None 18977058 Nonpathogen - hypothetical protein PF0686 1 None None None 18978324 Common - hypothetical protein PF1952 74 COG5270 COG5270, PUA domain (predicted RNA-binding domain) Translation, ribosomal structure and biogenesis 18978402 Common - ferredoxin-family protein PF2030 63 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 33359484 Nonpathogen - hypothetical transposase PF0538.1n 1 None None None 18976898 Common - soj - like protein PF0526 229 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 18978309 Common - putative malf-like sugar transport inner membrane protein PF1937 153 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 18978031 Common hisD histidinol dehydrogenase PF1659 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 18977024 Common - DEXX-box atpase PF0652 35 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 18978217 Common - murein hydrolase PF1845 84 COG1346 LrgB, Putative effector of murein hydrolase Cell envelope biogenesis, outer membrane 18978257 Common - glycosyl transferase PF1885 234 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 18977871 Nonpathogen - 30S ribosomal protein S19e PF1499 34 COG2238 RPS19A, Ribosomal protein S19E (S16A) Translation, ribosomal structure and biogenesis 18977187 Nonpathogen - hypothetical protein PF0815 1 None None None 18977358 Nonpathogen - DNA-directed RNA polymerase subunit M PF0986 33 COG1594 RPB9, DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS Transcription 18977976 Nonpathogen - hypothetical protein PF1604 7 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 18978276 Common - nicotinate phosphoribosyltransferase PF1904 115 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 18977741 Nonpathogen - 50S ribosomal protein L24e PF1369 32 COG2075 RPL24A, Ribosomal protein L24E Translation, ribosomal structure and biogenesis 18976702 Nonpathogen - flagellar assembly protein J PF0330 23 COG1955 FlaJ, Archaeal flagella assembly protein J Cell motility and secretion / Intracellular trafficking and secretion 18977655 Common - rubrerythrin PF1283 81 COG1592 COG1592, Rubrerythrin Energy production and conversion 18977744 Nonpathogen - hypothetical protein PF1372 2 None None None 18976994 Nonpathogen - hypothetical protein PF0622 1 None None None 18976538 Common - oxidoreductase PF0166 25 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 18977214 Common - hypothetical protein PF0842 11 None None None 18977885 Nonpathogen - hypothetical protein PF1513 1 None None None 18978250 Common - methylated-DNA--protein-cysteine methyltransferase PF1878 149 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 18976933 Nonpathogen - hypothetical protein PF0561 1 None None None 18977807 Common - mbh13 NADH dehydrogenase subunit PF1435 191 COG0650 HyfC, Formate hydrogenlyase subunit 4 Energy production and conversion 33359562 Nonpathogen - hypothetical protein PF1381 24 COG1860 COG1860, Uncharacterized protein conserved in archaea Function unknown 18976375 Common - moeB-like protein PF0003 193 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 18977053 Nonpathogen - hypothetical protein PF0681 1 None None None 33359582 Nonpathogen - hypothetical protein PF1915 2 None None None 33359589 Nonpathogen - hypothetical protein PF2018 4 COG3390 COG3390, Uncharacterized protein conserved in archaea Function unknown 18977524 Common - putative monovalent cation/H+ antiporter subunit F PF1152 32 COG2212 MnhF, Multisubunit Na+/H+ antiporter, MnhF subunit Inorganic ion transport and metabolism 18978172 Nonpathogen - adenylate kinase PF1800 25 COG2019 AdkA, Archaeal adenylate kinase Nucleotide transport and metabolism 18977182 Nonpathogen - hypothetical protein PF0810 17 COG4743 COG4743, Predicted membrane protein Function unknown 18978185 Nonpathogen rpl24p 50S ribosomal protein L24P PF1813 34 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 33359472 Nonpathogen - hypothetical protein PF0353 19 COG1423 COG1423, ATP-dependent DNA ligase, homolog of eukaryotic ligase III DNA replication, recombination, and repair 18976542 Common - hypothetical protein PF0170 36 COG0392 COG0392, Predicted integral membrane protein Function unknown 18978103 Common - signal recognition particle protein Srp54 PF1731 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 18976567 Nonpathogen - hypothetical protein PF0195 2 None None None 18976608 Common - ribose-phosphate pyrophosphokinase PF0236 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 18977135 Nonpathogen - hypothetical protein PF0763 1 None None None 33359522 Nonpathogen - hypothetical protein PF0886 3 None None None 18978096 Nonpathogen - hypothetical protein PF1724 12 COG1658 COG1658, Small primase-like proteins (Toprim domain) DNA replication, recombination, and repair 33359594 Common - hypothetical arylsulfatase regulatory protein PF2060.1n 24 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 18976624 Nonpathogen - 30S ribosomal protein S27ae PF0252 31 COG1998 RPS31, Ribosomal protein S27AE Translation, ribosomal structure and biogenesis 18977805 Common - mbh11 membrane bound hydrogenase beta (NADH dehydrogenase) PF1433 40 COG3262 HycE, Ni,Fe-hydrogenase III component G Energy production and conversion 18977314 Common - dihydroxy-acid dehydratase PF0942 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 18978196 Nonpathogen rpl4lp 50S ribosomal protein L4P PF1824 34 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 18976904 Common - hypothetical protein PF0532 210 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 18976511 Common - indolepyruvate oxidoreductase subunit B PF0139 92 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 18976449 Common - biotin--protein ligase PF0077 216 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 18976829 Common - metalloprotease PF0457 39 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 18977691 Nonpathogen - hypothetical protein PF1319 1 COG2105 COG2105, Uncharacterized conserved protein Function unknown 18977009 Nonpathogen - hypothetical protein PF0637 2 None None None 18976820 Common - putative mannose-1-phosphate guanyltransferase PF0448 169 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 18976409 Nonpathogen - hypothetical protein PF0037 3 None None None 18978083 Common trpC indole-3-glycerol-phosphate synthase PF1711 219 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 18977993 Nonpathogen - hypothetical protein PF1621 2 None None None 18977904 Common - NADH oxidase PF1532 246 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 18977397 Nonpathogen - hypothetical protein PF1025 2 None None None 18978035 Common - imidazoleglycerol-phosphate synthase, cyclase subunit PF1663 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 18977846 Nonpathogen - hypothetical protein PF1474 1 None None None 18976918 Nonpathogen - hypothetical protein PF0546 2 None None None 18977112 Common - heavy-metal transporting cpx-type atpase PF0740 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 18976872 Nonpathogen - met-10+ protein PF0500 35 COG2520 COG2520, Predicted methyltransferase General function prediction only 18976953 Nonpathogen - hypothetical protein PF0581 2 None None None 18978418 Nonpathogen - hypothetical protein PF2046 2 None None None 18977035 Nonpathogen - hypothetical protein PF0663 4 None None None 18976909 Nonpathogen - hypothetical protein PF0537 3 COG1431 COG1431, Uncharacterized protein containing piwi/argonaute domain Translation, ribosomal structure and biogenesis 18976501 Nonpathogen - hypothetical protein PF0129 6 COG1988 COG1988, Predicted membrane-bound metal-dependent hydrolases General function prediction only 18976968 Common - hypothetical mRNA 3'-end processing factor PF0596 86 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 18977119 Common - putative proline dipeptidase PF0747 192 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 18977561 Nonpathogen - hypothetical protein PF1189 2 None None None 18977074 Common - x-pro dipeptidase PF0702 91 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 18978152 Common - putative ABC transporter PF1780 125 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 18976479 Nonpathogen - hypothetical protein PF0107 2 None None None 18977591 Nonpathogen - hypothetical protein PF1219 2 None None None 18978148 Nonpathogen - hypothetical protein PF1776 11 COG2411 COG2411, Uncharacterized conserved protein Function unknown 18976946 Nonpathogen - hypothetical protein PF0574 7 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 18977378 Common - putative phosphate transport system permease protein C PF1006 225 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 18978041 Nonpathogen - hypothetical protein PF1669 2 None None None 18978232 Nonpathogen - archaemetzincin-like protein PF1860 30 COG1913 COG1913, Predicted Zn-dependent proteases General function prediction only 18978218 Nonpathogen - hypothetical protein PF1846 5 None None None 18978343 Common - anaerobic ribonucleoside triphosphate reductase PF1971 89 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 18977688 Common - hypothetical protein PF1316 2 None None None 18977417 Common adk adenylate kinase PF1045 230 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 18976706 Nonpathogen - putative flagella-related protein PF0334 2 COG3353 FlaF, Putative archaeal flagellar protein F Cell motility and secretion 18978016 Common rps9p 30S ribosomal protein S9P PF1644 116 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 18976522 Nonpathogen - hypothetical protein PF0150 2 None None None 18977273 Nonpathogen - hypothetical protein PF0901 1 None None None 18976442 Common - hypothetical protein PF0070 28 COG1340 COG1340, Uncharacterized archaeal coiled-coil protein Function unknown 18977339 Common porD pyuvate ferredoxin oxidoreductase subunit delta PF0967 78 COG1144 COG1144, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit Energy production and conversion 18978272 Nonpathogen - hypothetical protein PF1900 2 None None None 18978411 Common - hypothetical protein PF2039 20 COG1432 COG1432, Uncharacterized conserved protein Function unknown 18977452 Nonpathogen - hypothetical protein PF1080 1 None None None 18977933 Nonpathogen - 50S ribosomal protein L30e PF1561 29 COG1911 RPL30, Ribosomal protein L30E Translation, ribosomal structure and biogenesis 18977786 Nonpathogen - flap endonuclease-1 PF1414 34 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 18976989 Common - hydrogenase maturation protease PF0617 44 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 18977888 Common - GMP synthase subunit B PF1516 238 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 18977632 Nonpathogen - hypothetical protein PF1260 4 None None None 18976667 Common - n-type ATP pyrophosphatase superfamily PF0295 53 COG2102 COG2102, Predicted ATPases of PP-loop superfamily General function prediction only 33359533 Nonpathogen - hypothetical protein PF1015.1n 4 None None None 18976486 Common - GTP-binding protein PF0114 158 COG0218 COG0218, Predicted GTPase General function prediction only 18976469 Common - 43 kDa subunit bacteriochlorophyll synthase-like protein PF0097 123 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 18976645 Common - n-type ATP pyrophosphatase superfamily PF0273 156 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 18977876 Common - large helicase-related protein PF1504 239 COG1201 Lhr, Lhr-like helicases General function prediction only 18978394 Common - hypothetical protein PF2022 72 COG1237 COG1237, Metal-dependent hydrolases of the beta-lactamase superfamily II General function prediction only 18977823 Common - putative monovalent cation/H+ antiporter subunit G PF1451 85 COG1320 MnhG, Multisubunit Na+/H+ antiporter, MnhG subunit Inorganic ion transport and metabolism 18976810 Common - hypothetical protein PF0438 15 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 18978009 Common - mevalonate kinase PF1637 48 COG1577 ERG12, Mevalonate kinase Lipid metabolism 18978380 Nonpathogen rpl37ae 50S ribosomal protein L37Ae PF2008 34 COG1997 RPL43A, Ribosomal protein L37AE/L43A Translation, ribosomal structure and biogenesis 18977198 Common - putative transport membrane protein PF0826 229 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 18977044 Nonpathogen - hypothetical protein PF0672 2 COG3630 OadG, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, gamma subunit Energy production and conversion 18977852 Common - formaldehyde:ferredoxin oxidoreductase wor5 PF1480 59 COG2414 COG2414, Aldehyde:ferredoxin oxidoreductase Energy production and conversion 18977589 Nonpathogen - hypothetical protein PF1217 1 None None None 18977146 Nonpathogen - hypothetical protein PF0774 1 COG1753 COG1753, Uncharacterized conserved protein Function unknown 18976639 Common - ribosomal protein s18 alanine acetyltransferase PF0267 195 COG0456 RimI, Acetyltransferases General function prediction only 18976974 Common - hypothetical protein PF0602 79 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 18977548 Nonpathogen - hypothetical protein PF1176 2 None None None 18977446 Common - hypothetical protein PF1074 6 None None None 18977019 Common - heme biosynthesis protein PF0647 191 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 18977062 Nonpathogen - hypothetical protein PF0690 3 None None None 18977960 Nonpathogen - hypothetical protein PF1588 8 COG2428 COG2428, Uncharacterized conserved protein Function unknown 18977582 Common - dipeptide ABC transporter, permease protein PF1210 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 18976863 Nonpathogen - transcription initiation factor E subunit alpha PF0491 31 COG1675 TFA1, Transcription initiation factor IIE, alpha subunit Transcription 33359505 Nonpathogen - hypothetical protein PF0762 7 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 18976633 Nonpathogen - hypothetical protein PF0261 19 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 33359555 Nonpathogen - hypothetical protein PF1270 1 None None None 18976473 Nonpathogen - hypothetical protein PF0101 3 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 18976603 Nonpathogen - hypothetical protein PF0231 23 COG1888 COG1888, Uncharacterized protein conserved in archaea Function unknown 18977288 Common - hypothetical protein PF0916 6 COG3270 COG3270, Uncharacterized conserved protein Function unknown 18977345 Common - acetyl-CoA acetyltransferase PF0973 151 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 18976386 Nonpathogen - hypothetical protein PF0014 11 COG1935 COG1935, Uncharacterized conserved protein Function unknown 18977155 Common - hypothetical protein PF0783 25 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 18978137 Common - hypothetical protein PF1765 66 COG1872 COG1872, Uncharacterized conserved protein Function unknown 18977821 Common - putative monovalent cation/H+ antiporter subunit B PF1449 25 COG2111 MnhB, Multisubunit Na+/H+ antiporter, MnhB subunit Inorganic ion transport and metabolism 18976435 Common - 6,7-dimethyl-8-ribityllumazine synthase PF0063 230 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 18977999 Common - glycyl-tRNA synthetase PF1627 97 COG0423 GRS1, Glycyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 18976799 Common - phosphoribosylaminoimidazole carboxylase catalytic subunit PF0427 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 18978058 Common - acetyl-lysine deacetylase PF1686 144 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 18977230 Nonpathogen - hypothetical protein PF0858 21 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 18976951 Common - hypothetical protein PF0579 11 None None None 18978072 Common - chorismate synthase PF1700 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 18976586 Nonpathogen - n-type ATP pyrophosphatase PF0214 8 COG1365 COG1365, Predicted ATPase (PP-loop superfamily) General function prediction only 18978342 Common - putative multiple sugar-binding transport ATP-binding protein PF1970 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 18978057 Common argD acetylornithine/acetyl-lysine aminotransferase PF1685 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 18978247 Nonpathogen - hypothetical protein PF1875 2 None None None 18976617 Nonpathogen - hypothetical protein PF0245 1 None None None 18977865 Nonpathogen - hypothetical protein PF1493 14 COG5423 COG5423, Predicted metal-binding protein Function unknown 18978087 Common - pyrroline-5-carboxylate reductase PF1715 212 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 18977334 Nonpathogen - hypothetical protein PF0962 1 None None None 18978427 Common - hypothetical protein PF2055 50 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 18976842 Common - hypothetical protein PF0470 4 COG4043 COG4043, Uncharacterized conserved protein Function unknown 18976392 Common - hypothetical protein PF0020 125 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 18977438 Common - putative aminotransferase PF1066 212 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 33359564 Nonpathogen - hypothetical protein PF1431 4 None None None 18976817 Common - galactokinase PF0445 100 COG0153 GalK, Galactokinase Carbohydrate transport and metabolism 18978371 Common - glycine dehydrogenase subunit 1 PF1999 172 COG0403 GcvP, Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain Amino acid transport and metabolism 18978352 Nonpathogen - hypothetical protein PF1980 1 None None None 18978063 Common aroB 3-dehydroquinate synthase PF1691 205 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 18977892 Common - ABC transporter integral membrane protein PF1520 217 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 18977390 Nonpathogen - LSU ribosomal protein L41E PF1018 1 None None None 18977986 Nonpathogen - hypothetical protein PF1614 2 COG1241 MCM2, Predicted ATPase involved in replication control, Cdc46/Mcm family DNA replication, recombination, and repair 33359516 Nonpathogen - hypothetical protein PF0855.1n 2 None None None 18977501 Common - hypothetical protein PF1129 31 COG1353 COG1353, Predicted hydrolase of the HD superfamily (permuted catalytic motifs) General function prediction only 18977971 Common - undecaprenyl diphosphate synthase PF1599 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 18977577 Nonpathogen - hypothetical protein PF1205 32 COG1439 COG1439, Predicted nucleic acid-binding protein, consists of a PIN domain and a Zn-ribbon module General function prediction only 18978240 Common - integrase-recombinase protein PF1868 232 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 18976884 Nonpathogen - transcription factor PF0512 33 COG1813 COG1813, Predicted transcription factor, homolog of eukaryotic MBF1 Transcription 18977843 Nonpathogen - hypothetical protein PF1471 2 COG0630 VirB11, Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis Cell motility and secretion / Intracellular trafficking and secretion 18978203 Nonpathogen - archaeal histone a1 PF1831 24 COG2036 HHT1, Histones H3 and H4 Chromatin structure and dynamics 18977570 Common - sugar fermentation stimulation protein A PF1198 106 COG1489 SfsA, DNA-binding protein, stimulates sugar fermentation General function prediction only 18976596 Common - hypothetical protein PF0224 75 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 18977462 Common - putative ABC transporter PF1090 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18977278 Nonpathogen - hypothetical protein PF0906 5 COG3368 COG3368, Predicted permease General function prediction only 33359509 Nonpathogen - hypothetical protein PF0785.2n 2 COG1992 COG1992, Uncharacterized conserved protein Function unknown 33359536 Nonpathogen - hypothetical protein PF1073 2 None None None 18977160 Common - glycosyl transferase PF0788 225 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 18976411 Common - xanthine-guanine phosphoribosyltransferase PF0039 41 COG2236 COG2236, Predicted phosphoribosyltransferases General function prediction only 18977380 Common - putative ABC transport protein PF1008 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 18976565 Common - putative ABC transport ATP binding protein PF0193 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 18976963 Nonpathogen - hypothetical protein PF0591 5 None None None 18977855 Nonpathogen - hypothetical protein PF1483 1 None None None 18978225 Common - glucose-1-dehydrogenase PF1853 220 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 18976985 Common - hypothetical protein PF0613 37 COG1980 COG1980, Archaeal fructose 1,6-bisphosphatase Carbohydrate transport and metabolism 18977511 Nonpathogen - hypothetical protein PF1139 33 COG1258 COG1258, Predicted pseudouridylate synthase Translation, ribosomal structure and biogenesis 18977945 Common - hypothetical TLDD protein PF1573 168 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 18977251 Nonpathogen - hypothetical protein PF0879 1 None None None 18976768 Nonpathogen - hypothetical protein PF0396 2 None None None 18977032 Common - iron-sulfur cluster binding protein PF0660 81 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 18976699 Nonpathogen - hypothetical protein PF0327 1 None None None 18977914 Nonpathogen - small nuclear ribonucleoprotein PF1542 32 COG1958 LSM1, Small nuclear ribonucleoprotein (snRNP) homolog Transcription 18977328 Nonpathogen - hypothetical protein PF0956 1 None None None 18977776 Common - proteasome, subunit beta (multicatalytic endopeptidase complex beta subunit) PF1404 50 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 18976573 Common - aconitate hydratase PF0201 222 COG1048 AcnA, Aconitase A Energy production and conversion 18976692 Nonpathogen - hypothetical protein PF0320 4 None None None 18976792 Common - hypothetical protein PF0420 104 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 18977432 Nonpathogen - hypothetical protein PF1060 29 COG1779 COG1779, C4-type Zn-finger protein General function prediction only 33359494 Common - flavodoxin PF0633 11 COG0716 FldA, Flavodoxins Energy production and conversion 18977120 Nonpathogen - hypothetical protein PF0748 2 None None None 18977073 Nonpathogen - x-pro dipeptidase, N-terminal fragment PF0701 1 None None None 18978000 Common - hypothetical molybdenum cofactor biosynthesis protein A PF1628 152 COG2100 COG2100, Predicted Fe-S oxidoreductase General function prediction only 18977551 Nonpathogen - hypothetical protein PF1179 1 None None None 18977755 Common - hypothetical protein PF1383 14 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 18977012 Common - ATP-dependent RNA helicase, putative PF0640 125 COG1203 COG1203, Predicted helicases General function prediction only 18978336 Nonpathogen - hypothetical protein PF1964 29 COG2888 COG2888, Predicted Zn-ribbon RNA-binding protein with a function in translation Translation, ribosomal structure and biogenesis 18978170 Common - sarcosine oxidase, subunit beta PF1798 162 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 33359584 Nonpathogen - hypothetical protein PF1940.1n 1 None None None 18977951 Common - DNA topoisomerase VI subunit B PF1579 34 COG1389 COG1389, DNA topoisomerase VI, subunit B DNA replication, recombination, and repair 18976978 Common - hypothetical protein PF0606 146 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 18977614 Common - dehydrogenase subunit alpha PF1242 180 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 18976672 Nonpathogen - hypothetical protein PF0300 24 COG2266 COG2266, GTP:adenosylcobinamide-phosphate guanylyltransferase Coenzyme metabolism 18978167 Common - sarcosine oxidase subunit alpha PF1795 238 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 18976689 Common - hypothetical protein PF0317 157 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 18978288 Common - hypothetical protein PF1916 21 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 18977836 Nonpathogen - hypothetical protein PF1464 1 None None None 18977701 Common - H-II hydrogenase subunit beta PF1329 32 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 18978409 Nonpathogen - hypothetical protein PF2037 1 None None None 18977677 Nonpathogen - hypothetical protein PF1305 2 None None None 18977825 Common - putative monovalent cation/H+ antiporter subunit E PF1453 83 COG1863 MnhE, Multisubunit Na+/H+ antiporter, MnhE subunit Inorganic ion transport and metabolism 18977890 Common - thiamin-binding periplasmic protein precursor PF1518 139 COG4143 TbpA, ABC-type thiamine transport system, periplasmic component Coenzyme metabolism 18976490 Common - putative ABC transporter permease protein PF0118 142 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 18977125 Common - 2-oxoacid ferredoxin oxidoreductase subunit beta PF0753 119 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 18976591 Common - putative 6-pyruvoyl tetrahydrobiopterin synthase PF0219 72 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 18978028 Common - putative NADH oxidase PF1656 72 COG0778 NfnB, Nitroreductase Energy production and conversion 18977629 Common - putative nol1-nop2-sun family nucleolar protein III PF1257 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 18977725 Nonpathogen - hypothetical protein PF1353 8 None None None 18977750 Nonpathogen - ribonuclease P protein component 2 PF1378 22 COG1369 POP5, RNase P/RNase MRP subunit POP5 Translation, ribosomal structure and biogenesis 18978134 Nonpathogen - hypothetical protein PF1762 3 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 161484714 Common - RNA 2'-phosphotransferase-like protein PF0083 43 COG1859 KptA, RNA:NAD 2'-phosphotransferase Translation, ribosomal structure and biogenesis 18977781 Common - dipeptide transport system permease protein PF1409 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 18977363 Common tdh L-threonine 3-dehydrogenase PF0991 209 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 18978077 Common trpA tryptophan synthase subunit alpha PF1705 219 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 18978400 Common - nitrogenase reductase (n-terminus) PF2028 31 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 18977711 Nonpathogen - hypothetical protein PF1339 2 None None None 18977391 Nonpathogen - hypothetical protein PF1019 32 COG1407 COG1407, Predicted ICC-like phosphoesterases General function prediction only 18977316 Nonpathogen - hypothetical protein PF0944 12 COG1708 COG1708, Predicted nucleotidyltransferases General function prediction only 18977092 Nonpathogen - hypothetical protein PF0720 2 None None None 18977644 Common - hypothetical protein PF1272 100 COG1540 COG1540, Uncharacterized proteins, homologs of lactam utilization protein B General function prediction only 18977925 Common - putative nol1-nop2-sun family nucleolar protein I PF1553 207 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 18977222 Common - hypothetical protein PF0850 30 COG2108 COG2108, Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme General function prediction only 18978294 Common pcm protein-L-isoaspartate O-methyltransferase PF1922 163 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 18977730 Common - glycosyl transferase PF1358 200 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 18978274 Common - DNA repair helicase putative PF1902 105 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 18977262 Common leuS leucyl-tRNA synthetase PF0890 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 18977431 Common - hypothetical protein PF1059 33 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 18977739 Nonpathogen rpl7ae 50S ribosomal protein L7Ae PF1367 35 COG1358 RPL8A, Ribosomal protein HS6-type (S12/L30/L7a) Translation, ribosomal structure and biogenesis 18977966 Common - dolichol-phosphate mannose synthase PF1594 179 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 18977873 Nonpathogen - hypothetical protein PF1501 3 COG2457 COG2457, Uncharacterized conserved protein Function unknown 18977229 Common - ferrous iron transport protein b PF0857 220 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 18978201 Common - nucleotidyltransferase PF1829 91 COG1078 COG1078, HD superfamily phosphohydrolases General function prediction only 18977746 Common - lipoate-protein ligase a PF1374 97 COG0095 LplA, Lipoate-protein ligase A Coenzyme metabolism 18977554 Nonpathogen - hypothetical protein PF1182 2 None None None 18977487 Nonpathogen - hypothetical protein PF1115 34 COG2016 COG2016, Predicted RNA-binding protein (contains PUA domain) Translation, ribosomal structure and biogenesis 18978215 Common - chromosome segregation protein smc PF1843 185 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 18976450 Nonpathogen - 2-phosphoglycerate kinase PF0078 14 COG2074 COG2074, 2-phosphoglycerate kinase Carbohydrate transport and metabolism 18977352 Common - putative aspartate racemase PF0980 98 COG1794 RacX, Aspartate racemase Cell envelope biogenesis, outer membrane 18977878 Nonpathogen - hypothetical protein PF1506 2 None None None 18976545 Common - preprotein translocase subunit SecF PF0173 178 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 18976518 Nonpathogen - potassium channel, putative PF0146 16 COG3273 COG3273, Uncharacterized conserved protein Function unknown 18977051 Common - hypothetical protein PF0679 142 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 18978208 Nonpathogen - hypothetical protein PF1836 2 None None None 18977653 Common - superoxide reductase PF1281 23 COG2033 COG2033, Desulfoferrodoxin Energy production and conversion 18976664 Common - putative deoxyhypusine synthase PF0292 56 COG1899 DYS1, Deoxyhypusine synthase Posttranslational modification, protein turnover, chaperones 18977958 Common - hydrogenase expression/formation protein PF1586 154 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 18977185 Nonpathogen - hypothetical protein PF0813 3 None None None 18977788 Nonpathogen - hypothetical protein PF1416 2 None None None 33359451 Nonpathogen - hypothetical protein PF0131.1n 1 None None None 18977660 Common - putative thiamin biosynthesis protein thiI PF1288 103 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 18976838 Nonpathogen - hypothetical protein PF0466 2 None None None 18978252 Nonpathogen - hypothetical protein PF1880 19 COG1458 COG1458, Predicted DNA-binding protein containing PIN domain General function prediction only 18976935 Nonpathogen - hypothetical protein PF0563 1 None None None 18977899 Nonpathogen - hypothetical protein PF1527 1 None None None 18978187 Common rps17p 30S ribosomal protein S17P PF1815 91 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 18977376 Common - alkaline phosphatase IV precursor PF1004 85 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 18977212 Nonpathogen - hypothetical nucleotidyltransferase PF0840 2 COG2266 COG2266, GTP:adenosylcobinamide-phosphate guanylyltransferase Coenzyme metabolism 33359571 Nonpathogen - phospho-sugar mutase PF1729 8 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 18977268 Nonpathogen - hypothetical protein PF0896 1 None None None 18977219 Common - hypothetical protein PF0847 42 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 18976497 Nonpathogen - hypothetical protein PF0125 9 COG1873 COG1873, Uncharacterized conserved protein Function unknown 18976553 Nonpathogen - V-type ATP synthase subunit F PF0181 13 COG1436 NtpG, Archaeal/vacuolar-type H+-ATPase subunit F Energy production and conversion 33359470 Nonpathogen - hypothetical protein PF0342 2 COG5096 COG5096, Vesicle coat complex, various subunits Intracellular trafficking and secretion 18976488 Common - putative multiple sugar transport protein PF0116 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 18978194 Common rpl2p 50S ribosomal protein L2P PF1822 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 18976924 Common - arsenical-resistance protein acr3 PF0552 129 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 18977669 Nonpathogen - hypothetical protein PF1297 25 COG1931 COG1931, Uncharacterized protein conserved in archaea Function unknown 18978358 Nonpathogen - hypothetical protein PF1986 19 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 18977169 Common - hypothetical protein PF0797 30 COG5653 COG5653, Protein involved in cellulose biosynthesis (CelD) Cell envelope biogenesis, outer membrane 18977641 Common - methionine synthase PF1269 149 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 18978081 Common - anthranilate synthase component I PF1709 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 18978157 Common - H/ACA RNA-protein complex component Cbf5p PF1785 244 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 18977027 Common - serine/threonine-protein kinase PF0655 152 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 18978269 Nonpathogen - hypothetical protein PF1897 3 COG2390 DeoR, Transcriptional regulator, contains sigma factor-related N-terminal domain Transcription 18976529 Common - D-fructose-6-phosphate amidotransferase PF0157 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 18977652 Nonpathogen - hypothetical protein PF1280 2 None None None 18978362 Nonpathogen nusG transcription antitermination protein NusG PF1990 34 COG0250 NusG, Transcription antiterminator Transcription 18976459 Common - inosine-5'-monophosphate dehydrogenase related protein iv PF0087 203 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 18977249 Nonpathogen - hypothetical protein PF0877 1 None None None 18977743 Common - hypothetical protein PF1371 138 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 18977815 Common - NADH dehydrogenase subunit C PF1443 111 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 33359487 Nonpathogen - hypothetical protein PF0586.1n 1 None None None 161484708 Common - hypothetical protein PF1536 71 COG2110 COG2110, Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 General function prediction only 18977208 Common - cobalamin synthase PF0836 32 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 33359548 Nonpathogen - hypothetical protein PF1182.1n 1 None None None 18977477 Common - pyrazinamidase/nicotinamidase pxnc PF1105 162 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 18976739 Nonpathogen - hypothetical protein PF0367 6 None None None 33359486 Nonpathogen - hypothetical protein PF0571 1 None None None 18976831 Common - hypothetical protein PF0459 74 COG1912 COG1912, Uncharacterized conserved protein Function unknown 33359455 Common - hypothetical protein PF0133 16 COG2029 COG2029, Uncharacterized conserved protein Function unknown 18977611 Nonpathogen - hypothetical protein PF1239 2 None None None 18978129 Nonpathogen - hypothetical protein PF1757 5 None None None 18977290 Common truA tRNA pseudouridine synthase A PF0918 235 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 18978037 Common - histidinol-phosphate aminotransferase PF1665 229 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 18978367 Nonpathogen - hypothetical protein PF1995 1 None None None 18977906 Common - hypothetical stomatin PF1534 200 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 18978118 Common - hypothetical protein PF1746 51 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 33359541 Nonpathogen - hypothetical protein PF1112.1n 1 None None None 18976744 Common - molybdenum cofactor biosynthesis protein PF0372 136 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 18977672 Nonpathogen - hypothetical protein PF1300 5 COG1531 COG1531, Uncharacterized protein conserved in archaea Function unknown 18978333 Common - tungsten-containing formaldehyde ferredoxin oxidoreductase wor4 PF1961 59 COG2414 COG2414, Aldehyde:ferredoxin oxidoreductase Energy production and conversion 18977480 Common - putative alpha-dextrin endo-1, 6-alpha-glucosidase PF1108 59 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 18977715 Common - xaa-pro dipeptidase (proline dipeptidase) PF1343 248 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 18977605 Common - putative chitinase PF1233 47 COG3325 ChiA, Chitinase Carbohydrate transport and metabolism 18977984 Nonpathogen - hypothetical protein PF1612 2 None None None 18978435 Common - putative aminopeptidase PF2063 63 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 33359586 Nonpathogen - hypothetical protein PF1984.2n 1 None None None 18976532 Common - TLDD - like protein PF0160 170 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 18978124 Common - transposase PF1752 25 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18978161 Common - hydrolase related to 2-haloalkanoic acid dehalogenase PF1789 60 COG0546 Gph, Predicted phosphatases General function prediction only 33359448 Nonpathogen - hypothetical protein PF0095 3 COG1777 COG1777, Predicted transcriptional regulators Transcription 18977233 Common - phospho-sugar mutase PF0861 243 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 18976585 Common - hypothetical protein PF0213 24 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 18977225 Common - 5'-methylthioadenosine phosphorylase PF0853 168 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 18977041 Nonpathogen - hypothetical protein PF0669 3 COG0456 RimI, Acetyltransferases General function prediction only 18978399 Nonpathogen - hypothetical protein PF2027 1 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 18977206 Nonpathogen - hypothetical protein PF0834 11 None None None 18978359 Nonpathogen - hypothetical protein PF1987 2 None None None 18977695 Common - hypothetical protein PF1323 18 COG1724 COG1724, Predicted periplasmic or secreted lipoprotein Cell motility and secretion 18977259 Nonpathogen - hypothetical protein PF0887 1 None None None 18976991 Common - hypothetical protein PF0619 43 COG1661 COG1661, Predicted DNA-binding protein with PD1-like DNA-binding motif General function prediction only 18977168 Common - galactoside o-acetyltransferase PF0796 214 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 18977267 Common - putative ABC transporter PF0895 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18977812 Common - bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase PF1440 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 18977488 Common - glycerol-3-phosphate cytidyltransferase PF1116 157 COG0615 TagD, Cytidylyltransferase Cell envelope biogenesis, outer membrane / Lipid metabolism 18978310 Common - putative malE-like sugar binding protein PF1938 118 COG2182 MalE, Maltose-binding periplasmic proteins/domains Carbohydrate transport and metabolism 18977305 Common - DNA repair helicase rad3, putative PF0933 84 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 18977248 Nonpathogen - 50S ribosomal protein L15e PF0876 34 COG1632 RPL15A, Ribosomal protein L15E Translation, ribosomal structure and biogenesis 18977729 Common - UDP- or dTTP-glucose 4-epimerase or 4-6-dehydratase PF1357 234 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 18978259 Common - hypothetical protein PF1887 63 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 18976830 Common - nicotinamide-nucleotide adenylyltransferase PF0458 52 COG1056 NadR, Nicotinamide mononucleotide adenylyltransferase Coenzyme metabolism 18977928 Nonpathogen - peptidyl-tRNA hydrolase PF1556 34 COG1990 COG1990, Uncharacterized conserved protein Function unknown 18976540 Nonpathogen - hypothetical protein PF0168 2 None None None 18977479 Common - hit family protein PF1107 220 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 33359566 Nonpathogen rpl37e 50S ribosomal protein L37e PF1541 28 COG2126 RPL37A, Ribosomal protein L37E Translation, ribosomal structure and biogenesis 18977666 Nonpathogen - hypothetical protein PF1294 36 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 18976555 Common - V-type ATP synthase subunit B PF0183 247 COG1156 NtpB, Archaeal/vacuolar-type H+-ATPase subunit B Energy production and conversion 18978116 Common - trehalose/maltose transport ATP-hydrolyzing PF1744 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 18976929 Common fabG 3-ketoacyl-(acyl-carrier-protein) reductase PF0557 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 18977294 Nonpathogen - hypothetical protein PF0922 1 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 18977681 Nonpathogen - hypothetical protein PF1309 1 None None None 18977057 Common - hypothetical protein PF0685 25 COG2810 COG2810, Predicted type IV restriction endonuclease Defense mechanisms 18976930 Common - cation efflux system protein PF0558 218 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 18977077 Common - cytochrome c-type biogenesis protein PF0705 114 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 18978354 Nonpathogen - hypothetical protein PF1982 28 COG1650 COG1650, Uncharacterized protein conserved in archaea Function unknown 33359479 Nonpathogen - hypothetical protein PF0432.3n 1 None None None 18978100 Common - NDP-sugar synthase PF1728 239 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 18976902 Nonpathogen - hypothetical protein PF0530 2 None None None 18976563 Common - oligopeptide transport system permease protein PF0191 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 18978254 Common - cell division control protein 48, aaa family PF1882 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 18977720 Nonpathogen - hypothetical protein PF1348 2 None None None 18976400 Common - putative acetyl transferase PF0028 20 COG0456 RimI, Acetyltransferases General function prediction only 18977678 Nonpathogen - hypothetical protein PF1306 2 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 18977553 Nonpathogen - hypothetical protein PF1181 5 None None None 18977766 Common - phosphoglycerate dehydrogenase PF1394 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 18977216 Nonpathogen - hypothetical protein PF0844 6 None None None 18976387 Nonpathogen - hypothetical protein PF0015 33 COG1938 COG1938, Archaeal enzymes of ATP-grasp superfamily General function prediction only 18977772 Nonpathogen - hypothetical protein PF1400 2 None None None 18977707 Common - hydroxyethylthiazole kinase PF1335 77 COG2145 ThiM, Hydroxyethylthiazole kinase, sugar kinase family Coenzyme metabolism 18977667 Nonpathogen - transcription factor PF1295 34 COG2101 SPT15, TATA-box binding protein (TBP), component of TFIID and TFIIIB Transcription 18977186 Nonpathogen - hypothetical protein PF0814 2 None None None 18978189 Common - translation initiation factor Sui1 PF1817 50 COG0023 SUI1, Translation initiation factor 1 (eIF-1/SUI1) and related proteins Translation, ribosomal structure and biogenesis 18977793 Common - 4-aminobutyrate aminotransferase PF1421 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 18977096 Nonpathogen - hypothetical protein PF0724 3 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 18976398 Nonpathogen - tRNA CCA-pyrophosphorylase PF0026 34 COG1746 CCA1, tRNA nucleotidyltransferase (CCA-adding enzyme) Translation, ribosomal structure and biogenesis 18977819 Common - NADH dehydrogenase subunit N PF1447 211 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 18978271 Common - putative 2-deoxy-d-gluconate 3-dehydrogenase PF1899 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 18978188 Nonpathogen - ribonuclease P protein component 1 PF1816 25 COG1588 POP4, RNase P/RNase MRP subunit p29 Translation, ribosomal structure and biogenesis 18977795 Common - putative monovalent cation/H+ antiporter subunit E PF1423 69 COG1863 MnhE, Multisubunit Na+/H+ antiporter, MnhE subunit Inorganic ion transport and metabolism 18976377 Common - ABC transporter, ATP-binding protein PF0005 248 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 18977536 Common - putative Na+/H+ antiporter PF1164 169 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 18976804 Common - putative sugar-catabolism phosphotransferase PF0432 121 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 18976496 Common - hypothetical protein PF0124 44 COG1378 COG1378, Predicted transcriptional regulators Transcription 161484711 Common - aspartate kinase PF1053 234 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 18977518 Nonpathogen - hypothetical protein PF1146 2 None None None 18978308 Common - putative malg-like sugar transport inner membrane protein PF1936 139 COG3833 MalG, ABC-type maltose transport systems, permease component Carbohydrate transport and metabolism 18978221 Common - hypothetical cell division inhibitor minD PF1849 36 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 18978299 Nonpathogen - hypothetical protein PF1927 20 COG1326 COG1326, Uncharacterized archaeal Zn-finger protein General function prediction only 33359475 Nonpathogen - 50S ribosomal protein L31e PF0378 27 COG2097 RPL31A, Ribosomal protein L31E Translation, ribosomal structure and biogenesis 18976877 Nonpathogen - hypothetical protein PF0505 2 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 18977436 Nonpathogen - hypothetical protein PF1064 1 None None None 18978151 Common - putative ABC transporter PF1779 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 18976594 Common - hydrolase related to 2-haloalkanoic acid dehalogenase PF0222 164 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 18976808 Common - hypothetical protein PF0436 3 None None None 18977023 Nonpathogen - hypothetical protein PF0651 2 None None None 18978079 Common - N-(5'-phosphoribosyl)anthranilate isomerase PF1707 170 COG0135 TrpF, Phosphoribosylanthranilate isomerase Amino acid transport and metabolism 18977645 Common - hypothetical protein PF1273 110 COG2049 DUR1, Allophanate hydrolase subunit 1 Amino acid transport and metabolism 33359534 Common - hypothetical protein PF1050 14 COG1430 COG1430, Uncharacterized conserved protein Function unknown 18978264 Nonpathogen - hypothetical protein PF1892 32 COG1602 COG1602, Uncharacterized conserved protein Function unknown 18976717 Common - molybdopterin converting factor, subunit 1 PF0345 27 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 18977176 Common - methanol dehydrogenase regulator PF0804 197 COG0714 COG0714, MoxR-like ATPases General function prediction only 18976670 Nonpathogen - hypothetical protein PF0298 2 None None None 33359507 Nonpathogen - hypothetical protein PF0776.1n 1 None None None 18977931 Common rps12P 30S ribosomal protein S12P PF1559 246 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 18977107 Nonpathogen - hypothetical protein PF0735 2 None None None 18977514 Nonpathogen - hypothetical protein PF1142 30 COG2047 COG2047, Uncharacterized protein (ATP-grasp superfamily) General function prediction only 18976405 Nonpathogen - hypothetical protein PF0033 1 None None None 18977312 Common - 3-isopropylmalate dehydrogenase 2 PF0940 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 18978228 Common - trk system potassium uptake protein PF1856 150 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 18977756 Nonpathogen - hypothetical protein PF1384 2 None None None 18978021 Common rps4p 30S ribosomal protein S4 PF1649 126 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 18976783 Common - protein-export membrane protein PF0411 14 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 33359583 Nonpathogen - hypothetical protein PF1939.1n 1 None None None 18977241 Common aspC aspartyl-tRNA synthetase PF0869 249 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 18976795 Nonpathogen - hypothetical protein PF0423 1 None None None 18978292 Common - triosephosphate isomerase PF1920 42 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 18977850 Nonpathogen - hypothetical protein PF1478 4 None None None 18978284 Common - hypothetical protein PF1912 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 18977969 Common - heat shock protein x PF1597 168 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 18978213 Nonpathogen - hypothetical protein PF1841 1 None None None 18976677 Common - hypothetical protein PF0305 42 COG1865 COG1865, Uncharacterized conserved protein Function unknown 18976766 Common - UDP-n-acetylglucosamine-dolichyl-phosphate n-acetylglucosaminephosphotransferase PF0394 186 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 18977777 Common - cleavage and polyadenylation specifity factor protein PF1405 161 COG1782 COG1782, Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain General function prediction only 33359558 Common - hypothetical protein PF1315 20 COG1479 COG1479, Uncharacterized conserved protein Function unknown 18977395 Common - transposase PF1023 22 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18976399 Common - putative integral membrane transport protein PF0027 68 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 18977751 Nonpathogen - cell division protein pelota PF1379 33 COG1537 PelA, Predicted RNA-binding proteins General function prediction only 18976415 Common - phosphoenolpyruvate synthase PF0043 236 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 18977734 Common - hypothetical protein PF1362 177 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 18977000 Nonpathogen - hypothetical protein PF0628 1 None None None 18978015 Nonpathogen - DNA-directed RNA polymerase subunit N PF1643 34 COG1644 RPB10, DNA-directed RNA polymerase, subunit N (RpoN/RPB10) Transcription 18978131 Common - hypothetical protein PF1759 9 None None None 18977250 Nonpathogen - hypothetical protein PF0878 6 None None None 18977692 Nonpathogen - hypothetical protein PF1320 1 None None None 18977563 Nonpathogen - hypothetical protein PF1191 10 COG1659 COG1659, Uncharacterized protein, linocin/CFP29 homolog Function unknown 18977834 Common - glutamyl-tRNA(Gln) amidotransferase subunit E PF1462 211 COG2511 GatE, Archaeal Glu-tRNAGln amidotransferase subunit E (contains GAD domain) Translation, ribosomal structure and biogenesis 18977150 Nonpathogen - hypothetical protein PF0778 1 None None None 18977953 Common - rio1 protein, putative PF1581 63 COG1718 RIO1, Serine/threonine protein kinase involved in cell cycle control Signal transduction mechanisms / Cell division and chromosome partitioning 18976870 Nonpathogen - hypothetical protein PF0498 11 COG1645 COG1645, Uncharacterized Zn-finger containing protein General function prediction only 18978344 Common - hypothetical protein PF1972 40 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 18977300 Common - hypothetical protein PF0928 59 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 18976785 Nonpathogen - hypothetical protein PF0413 13 COG2430 COG2430, Uncharacterized conserved protein Function unknown 18977403 Common - divalent cation tolerance protein PF1031 120 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 18978369 Nonpathogen - hypothetical protein PF1997 1 None None None 18976858 Nonpathogen - hypothetical protein PF0486 11 COG2510 COG2510, Predicted membrane protein Function unknown 18978205 Nonpathogen - hypothetical protein PF1833 16 COG1913 COG1913, Predicted Zn-dependent proteases General function prediction only 18977157 Common - transposase PF0785 22 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18976474 Common - hypothetical protein PF0102 61 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 18977528 Common rbcL ribulose bisophosphate carboxylase PF1156 68 COG1850 RbcL, Ribulose 1,5-bisphosphate carboxylase, large subunit Carbohydrate transport and metabolism 18976668 Common cobD cobalamin biosynthesis protein PF0296 147 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 18977842 Common - hypothetical protein PF1470 85 COG1533 SplB, DNA repair photolyase DNA replication, recombination, and repair 18976757 Nonpathogen - hypothetical protein PF0385 2 None None None 18977068 Common - putative carbohydrate-binding protein PF0696 28 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 18978089 Common - translation initiation factor IF-2 subunit gamma PF1717 249 COG5257 GCD11, Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase) Translation, ribosomal structure and biogenesis 18978026 Common - hypothetical ABC transporter PF1654 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 18978066 Common - shikimate kinase PF1694 31 COG1685 COG1685, Archaeal shikimate kinase Amino acid transport and metabolism / Coenzyme metabolism 18978407 Common - transposase PF2035 25 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18976897 Common - cell division protein FtsZ PF0525 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 33359512 Nonpathogen - transposase PF0800 4 None None None 18976557 Common - partial alanyl-tRNA synthetase matches COOH terminus half PF0185 241 COG2872 COG2872, Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain General function prediction only 18977341 Common vorA 2-ketoisovalerate ferredoxin oxidoreductase subunit alpha PF0969 138 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 33359510 Nonpathogen - hypothetical protein PF0785.3n 1 None None None 18976818 Common - NDP-sugar synthase PF0446 30 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 18976379 Common - hypothetical protein PF0007 27 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 18976418 Nonpathogen - hypothetical protein PF0046 6 COG1822 COG1822, Predicted archaeal membrane protein Function unknown 33359543 Nonpathogen - hypothetical protein PF1121 11 COG1688 COG1688, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 33359556 Nonpathogen - hypothetical protein PF1284 4 None None None 18978017 Common rpl13p 50S ribosomal protein L13P PF1645 169 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 18976845 Nonpathogen - o-sialoglycoprotein endopeptidase PF0473 34 COG3642 COG3642, Mn2+-dependent serine/threonine protein kinase Signal transduction mechanisms 18976851 Nonpathogen - hypothetical protein PF0479 5 None None None 18978093 Common - hypothetical protein PF1721 21 COG1767 CitG, Triphosphoribosyl-dephospho-CoA synthetase Coenzyme metabolism 18978420 Common - peptidase PF2048 190 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 18976512 Common - putative sugar transporter protein PF0140 77 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 18977619 Common - hypothetical protein PF1247 17 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 18976616 Nonpathogen - hypothetical protein PF0244 1 None None None 18976866 Common - DNA topoisomerase I PF0494 248 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 18976638 Nonpathogen - tRNA-splicing endonuclease subunit alpha PF0266 34 COG1676 SEN2, tRNA splicing endonuclease Translation, ribosomal structure and biogenesis 18976661 Common - phosphoenolpyruvate carboxykinase PF0289 59 COG1274 PckA, Phosphoenolpyruvate carboxykinase (GTP) Energy production and conversion 18976950 Common - hypothetical protein PF0578 9 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 18977797 Common - putative monovalent cation/H+ antiporter subunit G PF1425 49 COG1320 MnhG, Multisubunit Na+/H+ antiporter, MnhG subunit Inorganic ion transport and metabolism 18977948 Nonpathogen - hypothetical protein PF1576 8 COG1710 COG1710, Uncharacterized protein conserved in archaea Function unknown 18977453 Nonpathogen - hypothetical protein PF1081 1 None None None 33359576 Common - hypothetical protein PF1844 33 COG1380 COG1380, Putative effector of murein hydrolase LrgA General function prediction only 18976761 Common - transposase PF0389 25 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18976826 Common - bacteriochlorophyll synthase, 43 kDa subunit PF0454 81 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 18977500 Nonpathogen - hypothetical protein PF1128 5 COG1769 COG1769, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 18977428 Common - aspartate-semialdehyde dehydrogenase PF1056 201 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 18977576 Common - seryl-tRNA synthetase PF1204 243 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 18976937 Nonpathogen - hypothetical protein PF0565 2 None None None 18977443 Common - asparagine synthetase PF1071 211 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 18976890 Common - hypothetical protein PF0518 97 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 33359592 Nonpathogen - hypothetical protein PF2048.1n 2 None None None 18978053 Nonpathogen - hypothetical protein PF1681 4 COG2995 PqiA, Uncharacterized paraquat-inducible protein A Function unknown 18977116 Common - ABC transporter, msbA subfamily PF0744 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 18976389 Nonpathogen cdc6 cell division control protein 6 PF0017 31 COG1474 CDC6, Cdc6-related protein, AAA superfamily ATPase DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones 18976860 Nonpathogen - 30S ribosomal protein S6e PF0488 34 COG2125 RPS6A, Ribosomal protein S6E (S10) Translation, ribosomal structure and biogenesis 18977174 Nonpathogen - hypothetical protein PF0802 1 None None None 33359568 Nonpathogen - hypothetical protein PF1584 2 None None None 18977292 Nonpathogen - nucleotidyltransferase PF0920 15 COG3294 COG3294, Uncharacterized conserved protein Function unknown 18977075 Nonpathogen - hypothetical protein PF0703 8 None None None 18976604 Nonpathogen - transcription regulatory protein, arsR family PF0232 3 COG4189 COG4189, Predicted transcriptional regulator Transcription 18976945 Nonpathogen - hypothetical protein PF0573 5 COG2002 AbrB, Regulators of stationary/sporulation gene expression Transcription 18977972 Common - ferripyochelin binding protein PF1600 213 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 18977449 Common - hypothetical protein PF1077 167 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 18976852 Common - lysophospholipase PF0480 104 COG2267 PldB, Lysophospholipase Lipid metabolism 18976705 Nonpathogen - putative flagella-related protein g PF0333 11 COG3354 FlaG, Putative archaeal flagellar protein G Cell motility and secretion 18977348 Nonpathogen - putative transmembrane protein PF0976 2 None None None 18977029 Common - putative dihydrodipicolinate synthase PF0657 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 18976583 Common - hypothetical protein PF0211 72 COG2263 COG2263, Predicted RNA methylase Translation, ribosomal structure and biogenesis 18976998 Common - hypothetical protein PF0626 20 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 18976770 Common - hypothetical protein PF0398 37 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 18978244 Nonpathogen - 50S ribosomal protein L35Ae PF1872 9 COG2451 COG2451, Ribosomal protein L35AE/L33A Translation, ribosomal structure and biogenesis 18977196 Common - hypothetical protein PF0824 191 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 18976888 Nonpathogen - hypothetical protein PF0516 2 None None None 18976758 Common - hypothetical protein PF0386 41 COG2517 COG2517, Predicted RNA-binding protein containing a C-terminal EMAP domain General function prediction only 18976461 Nonpathogen - met-10+ protein PF0089 35 COG2520 COG2520, Predicted methyltransferase General function prediction only 18976438 Nonpathogen - hypothetical protein PF0066 1 None None None 18977566 Common - furr family transcriptional regulator PF1194 56 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 18977283 Common - iron (III) ABC transporter PF0911 84 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 18976380 Common - hit family protein PF0008 132 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 18978315 Nonpathogen - hypothetical protein PF1943 2 None None None 18977961 Common - hypothetical protein PF1589 10 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 18978142 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit gamma PF1770 78 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 18977238 Nonpathogen - hypothetical protein PF0866 22 COG1624 COG1624, Uncharacterized conserved protein Function unknown 18976908 Common - transposase PF0536 22 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18977408 Nonpathogen - hypothetical protein PF1036 20 COG1460 COG1460, Uncharacterized protein conserved in archaea Function unknown 18977820 Common - putative monovalent cation/H+ antiporter subunit C PF1448 72 COG1006 MnhC, Multisubunit Na+/H+ antiporter, MnhC subunit Inorganic ion transport and metabolism 18977868 Nonpathogen - hypothetical protein PF1496 6 COG1800 COG1800, Predicted transglutaminase-like proteases General function prediction only 18978381 Nonpathogen - DNA-directed RNA polymerase subunit P PF2009 6 COG1996 RPC10, DNA-directed RNA polymerase, subunit RPC10 (contains C4-type Zn-finger) Transcription 18978414 Nonpathogen - hypothetical protein PF2042 34 COG1628 COG1628, Uncharacterized conserved protein Function unknown 18976737 Nonpathogen - hypothetical protein PF0365 2 COG1030 NfeD, Membrane-bound serine protease (ClpP class) Posttranslational modification, protein turnover, chaperones 18976688 Nonpathogen - hypothetical protein PF0316 2 None None None 18976681 Common - ABC transporter PF0309 13 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 18976575 Common - citrate synthase PF0203 193 COG0372 GltA, Citrate synthase Energy production and conversion 18976468 Common - hypothetical protein PF0096 58 COG2768 COG2768, Uncharacterized Fe-S center protein General function prediction only 18977822 Common - hypothetical protein PF1450 21 COG1563 COG1563, Predicted subunit of the Multisubunit Na+/H+ antiporter Inorganic ion transport and metabolism 18977039 Common - adenylosuccinate lyase PF0667 241 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 18976957 Common - DEXX-box atpase PF0585 29 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 18977683 Nonpathogen - hypothetical protein PF1311 1 None None None 18976914 Common - molybdenum cofactor biosynthesis protein PF0542 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 18977046 Common - ion gradient-generating decarboxylase subunit beta PF0674 56 COG1883 OadB, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit Energy production and conversion 18977030 Nonpathogen - hypothetical protein PF0658 2 None None None 18977231 Common - hypothetical protein PF0859 239 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 18976969 Common - hypothetical iaa-amino acid hydrolase 1 precursor PF0597 170 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 18977320 Nonpathogen - hypothetical protein PF0948 1 None None None 18976964 Common - ATP-dependent RNA helicase, putative PF0592 205 COG1205 COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster General function prediction only 18976423 Nonpathogen - hypothetical protein PF0051 4 COG3286 COG3286, Uncharacterized protein conserved in archaea Function unknown 18978074 Common - aspartate aminotransferase PF1702 231 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 18976506 Nonpathogen - hypothetical protein PF0134 14 COG0170 SEC59, Dolichol kinase Lipid metabolism 18977841 Common - glutamate/aspartate transport protein PF1469 164 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 18977994 Common - n-type ATP pyrophosphatase superfamily PF1622 7 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 18977621 Common - putative ABC transporter PF1249 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18977118 Common - hypothetical GufA-like protein PF0746 96 COG0428 COG0428, Predicted divalent heavy-metal cations transporter Inorganic ion transport and metabolism 18977423 Common - large helicase-related protein PF1051 201 COG1201 Lhr, Lhr-like helicases General function prediction only 18976973 Nonpathogen - hypothetical phosphomethylpyrimidine kinase PF0601 28 COG1992 COG1992, Uncharacterized conserved protein Function unknown 18977083 Common - hypothetical protein PF0711 15 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 18977003 Common - hypothetical protein PF0631 82 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 18976621 Common - ham1 protein PF0249 237 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 18977768 Common - 2-dehydropantoate 2-reductase PF1396 126 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 18978223 Common - hypothetical protein PF1851 37 COG1395 COG1395, Predicted transcriptional regulator Transcription 18978154 Nonpathogen - hypothetical protein PF1782 8 COG4346 COG4346, Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase Posttranslational modification, protein turnover, chaperones 18977509 Common - translation initiation factor IF-2 PF1137 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 18977458 Nonpathogen - hypothetical protein PF1086 28 COG2090 COG2090, Uncharacterized protein conserved in archaea Function unknown 33359493 Nonpathogen - hypothetical protein PF0630 1 None None None 18976749 Nonpathogen - translation initiation factor IF-6 PF0377 33 COG1976 TIF6, Translation initiation factor 6 (eIF-6) Translation, ribosomal structure and biogenesis 18977412 Nonpathogen - hypothetical protein PF1040 37 COG1833 COG1833, Uncharacterized conserved protein Function unknown 18977658 Common - hypothetical protein PF1286 184 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 18978191 Common rps3p 30S ribosomal protein S3P PF1819 240 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 18977234 Common - tyrosyl-tRNA synthetase PF0862 38 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 18976932 Nonpathogen - hypothetical protein PF0560 1 None None None 33359463 Nonpathogen - hypothetical protein PF0239 28 COG1698 COG1698, Uncharacterized protein conserved in archaea Function unknown 18977373 Common - oligopeptide transport system permease protein PF1001 194 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 18977661 Common - molybdopterin biosynthesis protein moeb PF1289 218 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 18976570 Common - phosphoribosylformylglycinamidine synthase subunit I PF0198 232 COG0047 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain Nucleotide transport and metabolism 18977296 Nonpathogen - hypothetical protein PF0924 1 None None None 18977048 Common - carbamate kinase-like carbamoyl phosphate synthetase PF0676 65 COG0549 ArcC, Carbamate kinase Amino acid transport and metabolism 18976814 Common - beta-glucosidase PF0442 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 18977055 Nonpathogen - hypothetical protein PF0683 1 None None None 18977451 Nonpathogen - hypothetical protein PF1079 11 COG1906 COG1906, Uncharacterized conserved protein Function unknown 18976579 Common - argininosuccinate synthase PF0207 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 18977359 Common - hypothetical protein PF0987 72 COG1515 Nfi, Deoxyinosine 3'endonuclease (endonuclease V) DNA replication, recombination, and repair 18976651 Common - putative ABC transporter PF0279 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 33359477 Nonpathogen - hypothetical protein PF0406.1n 1 None None None 18977808 Common - NADH-plastoquinone oxidoreductase subunit PF1436 131 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 18977184 Nonpathogen - hypothetical protein PF0812 3 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 18977875 Nonpathogen - hypothetical protein PF1503 20 COG1591 COG1591, Holliday junction resolvase - archaeal type DNA replication, recombination, and repair 18977774 Nonpathogen - hypothetical protein PF1402 2 None None None 18977791 Common - phosphoglycolate phosphatase PF1419 96 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 18976894 Common - aspartate aminotransferase PF0522 242 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 18978398 Common - putative polyferredoxin PF2026 29 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 18977367 Nonpathogen - hypothetical protein PF0995 2 None None None 18976534 Nonpathogen - hypothetical protein PF0162 2 None None None 18978018 Nonpathogen - 50S ribosomal protein L18e PF1646 34 COG1727 RPL18A, Ribosomal protein L18E Translation, ribosomal structure and biogenesis 18977939 Common - exosome complex RNA-binding protein Rrp42 PF1567 56 COG2123 COG2123, RNase PH-related exoribonuclease Translation, ribosomal structure and biogenesis 18976740 Common - hypothetical protein PF0368 173 COG0730 COG0730, Predicted permeases General function prediction only 18977982 Nonpathogen - hypothetical protein PF1610 1 None None None 33359446 Nonpathogen - putative ABC transporter, transmembrane component PF0011 15 COG1967 COG1967, Predicted membrane protein Function unknown 18977317 Nonpathogen - hypothetical protein PF0945 5 None None None 18977727 Common - NDP-sugar dehydrogenase PF1355 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 33359588 Nonpathogen - hypothetical protein PF2017 2 COG2433 COG2433, Uncharacterized conserved protein Function unknown 18976396 Common - putative glycerate kinase PF0024 86 COG2379 GckA, Putative glycerate kinase Carbohydrate transport and metabolism 18978317 Nonpathogen - n-type ATP pyrophosphatase superfamily PF1945 19 COG2117 COG2117, Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 18976835 Common - hydrolase related to 2-haloalkanoic acid dehalogenase PF0463 145 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 18978122 Common - putative sugar-binding transport ATP-binding protein PF1750 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 18977204 Nonpathogen - hypothetical protein PF0832 1 None None None 18977220 Nonpathogen - hypothetical protein PF0848 1 None None None 33359473 Nonpathogen - hypothetical protein PF0355 3 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 18977911 Common - dihydroorotate dehydrogenase 1B PF1539 211 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 18977227 Nonpathogen - hypothetical protein PF0855 1 COG1480 COG1480, Predicted membrane-associated HD superfamily hydrolase General function prediction only 18977897 Nonpathogen - hypothetical protein PF1525 1 None None None 18977764 Common - hypothetical protein PF1392 62 COG1293 COG1293, Predicted RNA-binding protein homologous to eukaryotic snRNP Transcription 18978234 Nonpathogen - DNA-binding protein PF1862 33 COG1491 COG1491, Predicted RNA-binding protein Translation, ribosomal structure and biogenesis 18978179 Nonpathogen rpl32e 50S ribosomal protein L32e PF1807 34 COG1717 RPL32, Ribosomal protein L32E Translation, ribosomal structure and biogenesis 18978207 Common - hypothetical protein PF1835 95 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 18976549 Common - V-type ATP synthase subunit I PF0177 49 COG1269 NtpI, Archaeal/vacuolar-type H+-ATPase subunit I Energy production and conversion 18977482 Nonpathogen - hypothetical protein PF1110 2 None None None 18977275 Common - hypothetical protein PF0903 36 COG1907 COG1907, Predicted archaeal sugar kinases General function prediction only 18977881 Nonpathogen - hypothetical protein PF1509 2 COG1991 COG1991, Uncharacterized conserved protein Function unknown 33359489 Nonpathogen - hypothetical protein PF0600 3 None None None 18978339 Common - hypothetical protein PF1967 25 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 18978363 Common rpl11p 50S ribosomal protein L11P PF1991 244 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 18977166 Common - UDP-n-acetylglucosamine 2-epimerase PF0794 151 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 18977246 Common - membrane dipeptidase PF0874 104 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 18977427 Common - threonine synthase PF1055 203 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 18977245 Nonpathogen - hypothetical protein PF0873 2 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 18976561 Common - dihydroorotase PF0189 209 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 18976491 Common - putative perplasmic sugar binding protein PF0119 26 COG2182 MalE, Maltose-binding periplasmic proteins/domains Carbohydrate transport and metabolism 18978105 Common - hypothetical protein PF1733 16 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 18976592 Common - hexulose-6-phosphate synthase (d-arabino 3-hexulose 6-phosphate formaldehyde lyase) PF0220 110 COG0269 SgbH, 3-hexulose-6-phosphate synthase and related proteins Carbohydrate transport and metabolism 18977748 Common rps10p 30S ribosomal protein S10P PF1376 245 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 18978114 Common - putative trehalose synthase PF1742 145 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 18977974 Common - glutamate dehydrogenase PF1602 179 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 18977693 Common - DEXX-box atpase PF1321 21 COG1373 COG1373, Predicted ATPase (AAA+ superfamily) General function prediction only 18978298 Common radA DNA repair and recombination protein RadA PF1926 38 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 18976824 Nonpathogen - hypothetical protein PF0452 9 COG2083 COG2083, Uncharacterized protein conserved in archaea Function unknown 18976686 Nonpathogen - hypothetical signal peptidase PF0314 1 None None None 18978226 Common moaC putative molybdenum cofactor biosynthesis protein C PF1854 196 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 18977717 Common - ribonuclease Z PF1345 130 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 33359524 Nonpathogen - hypothetical protein PF0900.1n 1 None None None 18977255 Nonpathogen - hypothetical protein PF0883 2 None None None 18977758 Nonpathogen - hypothetical protein PF1386 29 COG1709 COG1709, Predicted transcriptional regulator Transcription 18978286 Nonpathogen - ribonuclease P protein component 3 PF1914 14 COG1603 RPP1, RNase P/RNase MRP subunit p30 Translation, ribosomal structure and biogenesis 33359590 Nonpathogen - hypothetical protein PF2041 2 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 18978347 Common - hypothetical protein PF1975 17 COG1892 COG1892, Uncharacterized protein conserved in archaea Function unknown 18977025 Nonpathogen - hypothetical protein PF0653 1 None None None 18977036 Common - hypothetical protein PF0664 8 None None None 18976797 Nonpathogen - hypothetical protein PF0425 2 None None None 18977099 Common - hypothetical protein PF0727 21 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 18976982 Nonpathogen - hypothetical protein PF0610 19 COG3357 COG3357, Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon Transcription 18977385 Nonpathogen - hypothetical protein PF1013 2 None None None 18978405 Nonpathogen - hypothetical protein PF2033 28 COG1244 COG1244, Predicted Fe-S oxidoreductase General function prediction only 18978163 Nonpathogen - H/ACA RNA-protein complex component Gar1 PF1791 15 COG3277 GAR1, RNA-binding protein involved in rRNA processing Translation, ribosomal structure and biogenesis 33359532 Nonpathogen - hypothetical protein PF0982 2 COG1711 COG1711, Uncharacterized protein conserved in archaea Function unknown 18976883 Common - 3-methyladenine DNA glycosylase PF0511 49 COG0122 AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 18978331 Common - cofactor-independent phosphoglycerate mutase PF1959 51 COG3635 COG3635, Predicted phosphoglycerate mutase, AP superfamily Carbohydrate transport and metabolism 18978127 Common - fumarate hydratase PF1755 141 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 18977350 Nonpathogen - hypothetical protein PF0978 6 COG1800 COG1800, Predicted transglutaminase-like proteases General function prediction only 18976413 Common - putative oxidative cyclase PF0041 29 COG1031 COG1031, Uncharacterized Fe-S oxidoreductase Energy production and conversion 18977496 Common - hypothetical protein PF1124 24 COG1604 COG1604, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 18978013 Common - hypothetical protein PF1641 220 COG0148 Eno, Enolase Carbohydrate transport and metabolism 18977252 Common - DEXX-box atpase PF0880 36 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 18977179 Nonpathogen - hypothetical protein PF0807 5 None None None 18977810 Common - hypothetical protein PF1438 204 COG1750 COG1750, Archaeal serine proteases General function prediction only 18976806 Nonpathogen - hypothetical protein PF0434 1 None None None 18978301 Common - hypothetical protein PF1929 46 COG1836 COG1836, Predicted membrane protein Function unknown 18977105 Common - putative ABC transporter PF0733 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18977020 Nonpathogen - hypothetical protein PF0648 1 None None None 18976427 Nonpathogen - putative HTH transcription regulator PF0055 4 COG5625 COG5625, Predicted transcription regulator containing HTH domain Transcription 18976715 Common - S-adenosyl-L-homocysteine hydrolase PF0343 178 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 18976494 Common - translation initiation factor IF-2B subunit delta PF0122 132 COG1184 GCD2, Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 18977859 Common - thiamine biosynthesis protein ThiI PF1487 93 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 18977360 Nonpathogen - hypothetical protein PF0988 31 COG1339 COG1339, Transcriptional regulator of a riboflavin/FAD biosynthetic operon Transcription / Coenzyme metabolism 18977078 Nonpathogen - hypothetical protein PF0706 9 COG3370 COG3370, Uncharacterized protein conserved in archaea Function unknown 18976517 Common - hypothetical protein PF0145 74 COG1720 COG1720, Uncharacterized conserved protein Function unknown 18976443 Nonpathogen - hypothetical protein PF0071 25 COG1549 COG1549, Queuine tRNA-ribosyltransferases, contain PUA domain Translation, ribosomal structure and biogenesis 33359491 Nonpathogen - hypothetical transposase PF0604.1n 1 None None None 18977141 Common - glycosyl transferase PF0769 223 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 18977325 Nonpathogen - hypothetical protein PF0953 8 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 18977357 Nonpathogen - hypothetical DNA-directed RNA polymerase subunit M PF0985 24 COG2178 COG2178, Predicted RNA-binding protein of the translin family Translation, ribosomal structure and biogenesis 18976939 Common - hypothetical protein PF0567 39 COG1743 COG1743, Adenine-specific DNA methylase containing a Zn-ribbon DNA replication, recombination, and repair 18976971 Common pyrB aspartate carbamoyltransferase catalytic subunit PF0599 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 33359526 Common - hypothetical protein PF0908 31 COG1831 COG1831, Predicted metal-dependent hydrolase (urease superfamily) General function prediction only 18976723 Nonpathogen - hypothetical protein PF0351 1 None None None 18977664 Nonpathogen - hypothetical protein PF1292 1 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 18976696 Nonpathogen - hypothetical protein PF0324 3 None None None 18977638 Common - cystathionine gamma-synthase PF1266 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 18977617 Common - hypothetical d-nopaline dehydrogenase PF1245 57 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 18978278 Nonpathogen - adenosylmethionine-8-amino-7-oxononanoate aminotransferase PF1906 1 None None None 18977516 Nonpathogen - hypothetical protein PF1144 3 None None None 18977624 Common - hypothetical protein PF1252 49 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 18978433 Common - putative ABC transporter PF2061 15 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 33359547 Nonpathogen - putative monovalent cation/H+ antiporter subunit B PF1149 3 COG2111 MnhB, Multisubunit Na+/H+ antiporter, MnhB subunit Inorganic ion transport and metabolism 18976465 Common - replication factor C small subunit PF0093 77 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 18978312 Nonpathogen - hypothetical protein PF1940 5 COG1374 NIP7, Protein involved in ribosomal biogenesis, contains PUA domain Translation, ribosomal structure and biogenesis 18977194 Nonpathogen - hypothetical protein PF0822 1 None None None 18977355 Nonpathogen - DNA polymerase sliding clamp PF0983 34 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 18978068 Common - putative ABC sugar transporter PF1696 249 COG3845 COG3845, ABC-type uncharacterized transport systems, ATPase components General function prediction only 18977963 Common - dipeptide transport protein PF1591 35 COG2362 DppA, D-aminopeptidase Amino acid transport and metabolism 18978384 Common - elongation factor EF-2 PF2012 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 18977114 Common - putative ferritin PF0742 85 COG1528 Ftn, Ferritin-like protein Inorganic ion transport and metabolism 18978051 Common - 3-isopropylmalate dehydratase large subunit PF1679 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 18976996 Nonpathogen - hypothetical protein PF0624 10 COG2036 HHT1, Histones H3 and H4 Chromatin structure and dynamics 18978076 Nonpathogen - hypothetical protein PF1704 2 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 18976864 Nonpathogen - hypothetical protein PF0492 2 None None None 18978025 Nonpathogen - hypothetical protein PF1653 2 None None None 18977574 Nonpathogen - hypothetical protein PF1202 1 None None None 18978242 Nonpathogen - hypothetical protein PF1870 1 None None None 18976703 Common - putative type II secretion system protein PF0331 227 COG0630 VirB11, Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis Cell motility and secretion / Intracellular trafficking and secretion 18976721 Nonpathogen - hypothetical protein PF0349 2 None None None 18976920 Common - hydrogenase expression/formation protein PF0548 101 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 18977579 Nonpathogen - hypothetical protein PF1207 3 None None None 18977580 Common - beta-mannosidase PF1208 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 18977568 Nonpathogen - hypothetical protein PF1196 10 COG1633 COG1633, Uncharacterized conserved protein Function unknown 18977740 Nonpathogen rps28e 30S ribosomal protein S28e PF1368 33 COG2053 RPS28A, Ribosomal protein S28E/S33 Translation, ribosomal structure and biogenesis 18976772 Common - hypothetical protein PF0400 39 COG1041 COG1041, Predicted DNA modification methylase DNA replication, recombination, and repair 18978005 Common - hypothetical protein PF1633 38 COG1300 SpoIIM, Uncharacterized membrane protein Function unknown 18978111 Common - trehalose/maltose binding protein PF1739 131 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 18977465 Nonpathogen - hypothetical protein PF1093 1 None None None 33359551 Nonpathogen - hypothetical protein PF1218.1n 5 COG3379 COG3379, Uncharacterized conserved protein Function unknown 18977159 Nonpathogen - hypothetical protein PF0787 2 None None None 18976847 Common - translation initiation factor IF-2B subunit alpha PF0475 132 COG1184 GCD2, Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family Translation, ribosomal structure and biogenesis 18977080 Common - hypothetical protein PF0708 183 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 18978156 Nonpathogen - ADP-specific phosphofructokinase PF1784 8 COG4809 COG4809, Archaeal ADP-dependent phosphofructokinase/glucokinase Carbohydrate transport and metabolism 33359545 Nonpathogen - hypothetical protein PF1127 7 COG1517 COG1517, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 18977473 Common - hypothetical protein PF1101 161 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 18977421 Common - hypothetical protein PF1049 63 COG1313 PflX, Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins General function prediction only 33359500 Nonpathogen - hypothetical protein PF0706.1n 1 None None None 18977690 Nonpathogen - hypothetical protein PF1318 3 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 18977676 Nonpathogen - hypothetical protein PF1304 6 COG5306 COG5306, Uncharacterized conserved protein Function unknown 18976466 Common - glutaredoxin-like protein PF0094 86 COG3634 AhpF, Alkyl hydroperoxide reductase, large subunit Posttranslational modification, protein turnover, chaperones 18978370 Nonpathogen - hypothetical protein PF1998 4 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 18977830 Common - sugar kinase PF1458 191 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 18976631 Common - hypothetical protein PF0259 35 COG0011 COG0011, Uncharacterized conserved protein Function unknown 18978425 Common - transcriptional regulatory protein, asnC family PF2053 70 COG1522 Lrp, Transcriptional regulators Transcription 18976525 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase PF0153 218 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 18978375 Common - glycerophosphodiester phosphodiesterase PF2003 164 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 18976647 Common - Na+/H+ antiporter PF0275 206 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 18977779 Common pyrH uridylate kinase PF1407 77 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 18977919 Common - endoglucanase PF1547 91 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 18976762 Common - hypothetical protein PF0390 39 COG1679 COG1679, Uncharacterized conserved protein Function unknown 33359561 Nonpathogen - hypothetical protein PF1357.1n 1 None None None 161484705 Nonpathogen rpl15p 50S ribosomal protein L15P PF1802 17 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 18978033 Common hisH imidazole glycerol phosphate synthase subunit HisH PF1661 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 18978091 Common - intracellular protease PF1719 167 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 18978330 Nonpathogen - hypothetical protein PF1958 7 COG1818 COG1818, Predicted RNA-binding protein, contains THUMP domain General function prediction only 18978085 Common - carbamoyl phosphate synthase small subunit PF1713 233 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 18977366 Common - type II secretion system protein PF0994 204 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 18978326 Common - hypothetical protein PF1954 23 COG1763 MobB, Molybdopterin-guanine dinucleotide biosynthesis protein Coenzyme metabolism 18976453 Common - sulfate/thiosulfate transport-like protein PF0081 231 COG0555 CysU, ABC-type sulfate transport system, permease component Posttranslational modification, protein turnover, chaperones 18977507 Common - heat shock protein HtpX PF1135 191 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 18976577 Common - glutamate synthase subunit alpha PF0205 204 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 18977394 Common - transcriptional regulatory protein, asnC family PF1022 42 COG1522 Lrp, Transcriptional regulators Transcription 18977883 Nonpathogen - hypothetical protein PF1511 1 None None None 18978337 Nonpathogen ef1B elongation factor 1-beta PF1965 18 COG2092 EFB1, Translation elongation factor EF-1beta Translation, ribosomal structure and biogenesis 18977277 Common - putative ABC transporter PF0905 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18978182 Nonpathogen rps14P 30S ribosomal protein S14P PF1810 30 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 18976581 Common - ribosomal protein s6 modification protein PF0209 101 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 18976421 Common - cytosine-specific DNA-methyltransferase PF0049 113 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 18976445 Common - beta-glucosidase PF0073 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 18977124 Common - thioredoxin peroxidase PF0752 209 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 18977800 Common - putative monovalent cation/H+ antiporter subunit B PF1428 17 COG2111 MnhB, Multisubunit Na+/H+ antiporter, MnhB subunit Inorganic ion transport and metabolism 18977902 Common - putative thiazole biosynthetic enzyme PF1530 32 COG1635 THI4, Flavoprotein involved in thiazole biosynthesis Coenzyme metabolism 18976606 Nonpathogen - hypothetical protein PF0234 3 None None None 18976729 Common - dipeptide-binding protein PF0357 167 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 18977180 Nonpathogen - hypothetical protein PF0808 2 None None None 18977131 Nonpathogen - hypothetical protein PF0759 12 None None None 18977599 Nonpathogen - transposase PF1227 1 None None None 18976658 Nonpathogen - hypothetical protein PF0286 3 COG3780 COG3780, DNA endonuclease related to intein-encoded endonucleases DNA replication, recombination, and repair 18977941 Nonpathogen - exosome complex RNA-binding protein Rrp4 PF1569 24 COG1097 RRP4, RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain) Translation, ribosomal structure and biogenesis 18976640 Common - Na+/H+ antiporter - like protein PF0268 178 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 18978107 Common - adenine phosphoribosyltransferase PF1735 97 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 18977456 Nonpathogen - phosphopantetheine adenylyltransferase PF1084 28 COG1019 COG1019, Predicted nucleotidyltransferase General function prediction only 18978392 Nonpathogen - replication factor A PF2020 20 COG1599 RFA1, Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins DNA replication, recombination, and repair 18976550 Common - V-type ATP synthase subunit K PF0178 21 None None None 18977285 Common - hypothetical protein PF0913 34 COG2191 COG2191, Formylmethanofuran dehydrogenase subunit E Energy production and conversion 18977541 Nonpathogen - hypothetical protein PF1169 5 COG4031 COG4031, Predicted metal-binding protein General function prediction only 18977152 Common - transposase PF0780 25 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18978346 Common - thermosome, single subunit PF1974 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 18977414 Nonpathogen - hypothetical protein PF1042 2 None None None 18977866 Nonpathogen - hypothetical protein PF1494 1 COG2245 COG2245, Predicted membrane protein Function unknown 18977587 Common - hypothetical SUA5 protein PF1215 17 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 18976942 Nonpathogen - hypothetical protein PF0570 1 None None None 18977635 Nonpathogen - hypothetical protein PF1263 2 None None None 18976404 Nonpathogen - hypothetical permease PF0032 3 None None None 18977401 Nonpathogen - hypothetical protein PF1029 7 COG2512 COG2512, Uncharacterized membrane-associated protein/domain Function unknown 18977989 Common - hypothetical protein PF1617 9 COG3463 COG3463, Predicted membrane protein Function unknown 18977303 Common ndk nucleoside diphosphate kinase PF0931 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 18978144 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit beta PF1772 120 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 18978149 Common - hydrolase related to 2-haloalkanoic acid dehalogenase PF1777 155 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 18976713 Nonpathogen - hypothetical protein PF0341 4 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 18976947 Nonpathogen - hypothetical protein PF0575 3 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 18976940 Common - hypothetical protein PF0568 29 COG1743 COG1743, Adenine-specific DNA methylase containing a Zn-ribbon DNA replication, recombination, and repair 18977189 Common - transposase PF0817 25 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18976718 Common - aldehyde:ferredoxin oxidoreductase PF0346 57 COG2414 COG2414, Aldehyde:ferredoxin oxidoreductase Energy production and conversion 18977828 Common - hypothetical protein PF1456 4 COG3153 COG3153, Predicted acetyltransferase General function prediction only 18977856 Common - hypothetical protein PF1484 45 COG1407 COG1407, Predicted ICC-like phosphoesterases General function prediction only 18977685 Common - hypothetical DNA processing smf protein PF1313 210 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 18976949 Common - ATP-binding transport protein PF0577 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18977129 Nonpathogen - hypothetical protein PF0757 2 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 18976735 Common - beta-galactosidase precursor PF0363 29 COG1874 LacA, Beta-galactosidase Carbohydrate transport and metabolism 18978236 Common - transposase PF1864 25 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18976514 Common - asparaginase PF0142 84 COG1446 COG1446, Asparaginase Amino acid transport and metabolism 18977164 Common - hypothetical protein PF0792 24 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 18978042 Common - alkaline serine protease PF1670 151 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 18978175 Nonpathogen rpl30p 50S ribosomal protein L30P PF1803 34 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 18977177 Nonpathogen - hypothetical protein PF0805 1 None None None 18977103 Common - copper-transporting atpase, p-type PF0731 126 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 18977922 Common - hypothetical protein PF1550 63 COG0622 COG0622, Predicted phosphoesterase General function prediction only 18978135 Common - GTP-binding protein, gtp1/obg family PF1763 249 COG1163 DRG, Predicted GTPase General function prediction only 18976530 Nonpathogen - hypothetical protein PF0158 8 None None None 18976590 Nonpathogen rps27e 30S ribosomal protein S27e PF0218 34 COG2051 RPS27A, Ribosomal protein S27E Translation, ribosomal structure and biogenesis 18977704 Common - H-II alpha (hydrogenase subunit alpha) PF1332 106 COG3259 FrhA, Coenzyme F420-reducing hydrogenase, alpha subunit Energy production and conversion 18977510 Common - hypothetical protein PF1138 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 18977091 Nonpathogen - hypothetical protein PF0719 2 None None None 18977712 Nonpathogen - hypothetical protein PF1340 2 None None None 18977837 Nonpathogen - hypothetical protein PF1465 1 None None None 33359528 Nonpathogen - hypothetical protein PF0947 6 None None None 18976419 Nonpathogen - hypothetical protein PF0047 3 None None None 18977738 Common - transposase PF1366 26 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18978303 Common - hypothetical protein PF1931 105 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 18976988 Common - nucleotide-binding protein, mrp/nbp35 family PF0616 228 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 18978275 Common - hypothetical translation initiation factor IF-2 PF1903 24 COG3372 COG3372, Uncharacterized conserved protein Function unknown 18978293 Common - phosphoserine phosphatase PF1921 129 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 18977733 Common - glycosyl transferase PF1361 229 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 18977780 Common - putative dipeptide-binding protein PF1408 198 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 18977550 Common - putative na-dependant transporter PF1178 163 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 18977392 Common - putative phosphate transport protein pitb PF1020 173 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 18977634 Nonpathogen - ribosome biogenesis protein PF1262 18 COG1756 Mra1, Uncharacterized conserved protein Function unknown 18977942 Nonpathogen - hypothetical protein PF1570 34 COG1500 COG1500, Predicted exosome subunit Translation, ribosomal structure and biogenesis 18977265 Common - sulfhydrogenase delta subunit PF0893 37 COG1941 FrhG, Coenzyme F420-reducing hydrogenase, gamma subunit Energy production and conversion 18978313 Common - dihydropteroate synthase PF1941 31 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 18977532 Common - hypothetical protein PF1160 25 COG0170 SEC59, Dolichol kinase Lipid metabolism 18976448 Common - endo-beta-1,3-glucanase PF0076 50 COG2273 SKN1, Beta-glucanase/Beta-glucan synthetase Carbohydrate transport and metabolism 18977491 Common - hypothetical protein PF1119 35 COG1468 COG1468, RecB family exonuclease DNA replication, recombination, and repair 33359549 Nonpathogen - hypothetical protein PF1183 1 None None None 18976801 Common - putative proline permease PF0429 180 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 18977754 Common egsA NAD(P)-dependent glycerol-1-phosphate dehydrogenase PF1382 145 COG0371 GldA, Glycerol dehydrogenase and related enzymes Energy production and conversion 18977583 Common - dipeptide ABC transporter, permease protein PF1211 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 18977854 Nonpathogen - hypothetical protein PF1482 1 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 18976673 Common - cobyric acid synthase PF0301 154 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 18977011 Nonpathogen - hypothetical protein PF0639 5 COG2254 COG2254, Predicted HD superfamily hydrolase, possibly a nuclease DNA replication, recombination, and repair 18978378 Common - NADH oxidase PF2006 67 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 18976393 Common radB DNA repair and recombination protein RadB PF0021 222 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 18976923 Nonpathogen - hypothetical protein PF0551 2 None None None 18976614 Nonpathogen - transposase PF0242 1 None None None 18976599 Nonpathogen - hypothetical protein PF0227 1 None None None 18976769 Common - GTP-binding protein PF0397 164 COG0486 ThdF, Predicted GTPase General function prediction only 18978285 Nonpathogen - hypothetical protein PF1913 28 COG1325 COG1325, Predicted exosome subunit Translation, ribosomal structure and biogenesis 18977965 Nonpathogen - peptide chain release factor 1 PF1593 34 COG1503 eRF1, Peptide chain release factor 1 (eRF1) Translation, ribosomal structure and biogenesis 18978166 Common - inosine-5'-monophosphate dehydrogenase related protein I PF1794 105 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 18976537 Common - hydrolase related to 2-haloalkanoic acid dehalogenase PF0165 54 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 18978198 Nonpathogen - hypothetical protein PF1826 22 COG2106 COG2106, Uncharacterized conserved protein Function unknown 18978430 Nonpathogen - hypothetical protein PF2058 3 None None None 18977351 Common - hypothetical protein PF0979 127 COG2096 COG2096, Uncharacterized conserved protein Function unknown 18977998 Common - hypothetical protein PF1626 4 COG2306 COG2306, Uncharacterized conserved protein Function unknown 18977719 Nonpathogen - hypothetical protein PF1347 2 None None None 18977435 Nonpathogen - hypothetical protein PF1063 34 COG1736 DPH2, Diphthamide synthase subunit DPH2 Translation, ribosomal structure and biogenesis 18977537 Common - hypothetical protein PF1165 92 COG0433 COG0433, Predicted ATPase General function prediction only 18976811 Nonpathogen - hypothetical protein PF0439 2 None None None 18977329 Nonpathogen - hypothetical protein PF0957 1 None None None 18976906 Common - indolepyruvate oxidoreductase subunit B PF0534 106 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 18977917 Nonpathogen nac nascent polypeptide-associated complex protein PF1545 32 COG1308 EGD2, Transcription factor homologous to NACalpha-BTF3 Transcription 18977838 Nonpathogen - hypothetical protein PF1466 1 None None None 18978155 Common - molybdenum cofactor biosynthesis protein PF1783 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 18977122 Common - putative NADH oxidase PF0750 79 COG0778 NfnB, Nitroreductase Energy production and conversion 18977338 Common porA pyruvate ferredoxin oxidoreductase subunit alpha PF0966 117 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 18977405 Common - peroxiredoxin PF1033 212 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 18978296 Common - d-aminopeptidase PF1924 59 COG3191 DmpA, L-aminopeptidase/D-esterase Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism 18977799 Common - hypothetical protein PF1427 39 COG2111 MnhB, Multisubunit Na+/H+ antiporter, MnhB subunit Inorganic ion transport and metabolism 33359539 Nonpathogen - hypothetical protein PF1093.1n 1 None None None 18978280 Nonpathogen - hypothetical protein PF1908 1 None None None 18977498 Common - hypothetical protein PF1126 33 COG1336 COG1336, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 18978125 Common gltX glutamyl-tRNA synthetase PF1753 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 18977475 Common ppnK inorganic polyphosphate/ATP-NAD kinase PF1103 236 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 161484715 Common - D-cysteine desulfhydrase PF0010 89 COG2515 Acd, 1-aminocyclopropane-1-carboxylate deaminase Amino acid transport and metabolism 18978062 Common - 3-deoxy-7-phosphoheptulonate synthase PF1690 186 COG2876 AroA, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 18978403 Common - iron-sulfur cluster binding protein PF2031 64 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 18976916 Common - hypothetical protein PF0544 140 COG0432 COG0432, Uncharacterized conserved protein Function unknown 18977371 Nonpathogen - oligopeptide transport system permease protein appc, c-terminal fragment PF0999 4 None None None 18977724 Nonpathogen - hypothetical protein PF1352 7 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 18978396 Common - transposase PF2024 36 COG0675 COG0675, Transposase and inactivated derivatives DNA replication, recombination, and repair 18978410 Common - cob(I)yrinic acid a,c-diamide adenosyltransferase PF2038 142 COG2109 BtuR, ATP:corrinoid adenosyltransferase Coenzyme metabolism 18977309 Common - 2-isopropylmalate synthase PF0937 212 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 18978251 Nonpathogen - o-linked glcnac transferase PF1879 3 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 33359450 Nonpathogen - hypothetical protein PF0130 2 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 18977484 Nonpathogen - hypothetical protein PF1112 1 None None None 18977221 Common - hypothetical protein PF0849 26 COG1625 COG1625, Fe-S oxidoreductase, related to NifB/MoaA family Energy production and conversion 33359481 Nonpathogen - hypothetical protein PF0439.3n 1 None None None 18977143 Common - NDP-sugar dehydrogenase PF0771 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 18977415 Common - hypothetical protein PF1043 14 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 18978417 Nonpathogen - hypothetical protein PF2045 1 None None None 18976580 Common - argininosuccinate lyase PF0208 218 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 33359580 Nonpathogen - hypothetical protein PF1890 2 None None None 18977291 Nonpathogen - hypothetical protein PF0919 1 None None None 18977370 Common - hypothetical GTP-binding protein PF0998 162 COG1161 COG1161, Predicted GTPases General function prediction only 18976899 Nonpathogen - hypothetical protein PF0527 2 None None None 18977702 Common - cytochrome-c3 hydrogenase subunit gamma PF1330 167 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 18976559 Common - putative cofactor synthesis protein PF0187 46 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 18977052 Common - hypothetical protein PF0680 132 COG0432 COG0432, Uncharacterized conserved protein Function unknown 18978323 Common - asparagine synthetase A PF1951 173 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 18976544 Common - O-sialoglycoprotein endopeptidase PF0172 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 18978120 Common - putative sulfate transport system permease protein, ABC transporter PF1748 213 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 18977615 Nonpathogen - hypothetical protein PF1243 4 None None None 18977163 Common - hypothetical protein PF0791 227 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 18977466 Nonpathogen - hypothetical protein PF1094 1 None None None 33359462 Nonpathogen - hypothetical protein PF0238 5 COG4933 COG4933, Uncharacterized conserved protein Function unknown 18976743 Common - putative transporter PF0371 88 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 18977016 Nonpathogen - hypothetical protein PF0644 2 COG3682 COG3682, Predicted transcriptional regulator Transcription 18976471 Common - hypothetical protein PF0099 3 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 18978110 Common - sugar kinase PF1738 199 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 18977209 Nonpathogen - cobalamin (5'-phosphate) synthase, c-terminal fragment PF0837 2 None None None 18977895 Nonpathogen - hypothetical protein PF1523 1 None None None 33359454 Nonpathogen - hypothetical protein PF0132 6 COG4697 COG4697, Uncharacterized protein conserved in archaea Function unknown 18977816 Common - NADH dehydrogenase subunit B PF1444 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 18976456 Nonpathogen - hypothetical protein PF0084 1 None None None 18977596 Nonpathogen - hypothetical protein PF1224 3 COG5559 COG5559, Uncharacterized conserved small protein Function unknown 18977762 Nonpathogen - hypothetical protein PF1390 2 None None None 18977202 Common - hypothetical protein PF0830 9 COG1030 NfeD, Membrane-bound serine protease (ClpP class) Posttranslational modification, protein turnover, chaperones 18977867 Common - GTP-binding protein, gtp1/obg family PF1495 235 COG1084 COG1084, Predicted GTPase General function prediction only 18977924 Common - hypothetical protein PF1552 26 COG1371 COG1371, Uncharacterized conserved protein Function unknown 18977699 Common - putative oxidoreductase PF1327 244 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 18978209 Common - hypothetical protein PF1837 137 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 18976663 Common - prephenate dehydratase PF0291 214 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 18976738 Nonpathogen - hypothetical protein PF0366 18 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 18977647 Nonpathogen - hypothetical protein PF1275 25 COG2412 COG2412, Uncharacterized conserved protein Function unknown 18977060 Common - subtilisin-like protease PF0688 129 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 18976834 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PF0462 65 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 18977936 Common - DNA-directed RNA polymerase subunit beta PF1564 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 18977882 Nonpathogen - hypothetical protein PF1510 2 None None None 18977181 Nonpathogen - hypothetical protein PF0809 1 None None None 18977310 Common - 3-isopropylmalate dehydratase large subunit PF0938 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 18977806 Common - mbh12 membrane bound hydrogenase alpha (NADH dehydrogenase) PF1434 192 COG3261 HycE, Ni,Fe-hydrogenase III large subunit Energy production and conversion 18976934 Common - transposase PF0562 25 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18976572 Common - hypothetical protein PF0200 216 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 18977950 Common - DNA topoisomerase VI subunit A PF1578 34 COG1697 COG1697, DNA topoisomerase VI, subunit A DNA replication, recombination, and repair 18976374 Common - hypothetical protein PF0002 39 COG1944 COG1944, Uncharacterized conserved protein Function unknown 18978104 Nonpathogen - transcriptional regulatory protein, asnC family PF1732 22 COG1522 Lrp, Transcriptional regulators Transcription 18978350 Common - nicotinate-nucleotide pyrophosphorylase PF1978 205 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 18976543 Nonpathogen - hypothetical protein PF0171 5 None None None 18978261 Common - daunorubicin resistance ATP-binding protein drrA PF1889 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18978117 Nonpathogen - hypothetical protein PF1745 6 COG2407 FucI, L-fucose isomerase and related proteins Carbohydrate transport and metabolism 18978049 Common - hypothetical protein PF1677 116 COG1268 BioY, Uncharacterized conserved protein General function prediction only 18978322 Common - xanthine-guanine phosphoribosyltransferase PF1950 75 COG2236 COG2236, Predicted phosphoribosyltransferases General function prediction only 18977977 Nonpathogen - hypothetical protein PF1605 1 None None None 18977783 Common - dipeptide transport ATP-binding protein PF1411 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 18977651 Nonpathogen rpl10e 50S ribosomal protein L10e PF1279 34 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 18976993 Nonpathogen - hypothetical protein PF0621 3 COG2512 COG2512, Uncharacterized membrane-associated protein/domain Function unknown 18977742 Common - hypothetical protein PF1370 94 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18977492 Common - hypothetical ATP-dependent RNA helicase PF1120 94 COG1203 COG1203, Predicted helicases General function prediction only 18976509 Common - putative methyltransferase PF0137 181 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 18977745 Common - cation transporter, putative PF1373 211 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 18976733 Common - oligopeptide ABC transporter PF0361 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 18977562 Nonpathogen - hypothetical protein PF1190 2 COG1633 COG1633, Uncharacterized conserved protein Function unknown 18977228 Common - isopentenyl pyrophosphate isomerase PF0856 89 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 33359471 Common - hypothetical protein PF0352 9 COG1367 COG1367, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 18978036 Common - phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-atp PF1664 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 18977543 Nonpathogen - hypothetical protein PF1171 2 None None None 18977975 Common - hypothetical na antiporter PF1603 92 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 18976925 Common - arsenate reductase PF0553 134 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 18977279 Nonpathogen - hypothetical protein PF0907 5 COG5256 TEF1, Translation elongation factor EF-1alpha (GTPase) Translation, ribosomal structure and biogenesis 18976607 Common - glucose-1-phosphate thymidylyltransferase PF0235 242 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 18978263 Common - hypothetical protein PF1891 75 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 18977361 Common pheS phenylalanyl-tRNA synthetase subunit alpha PF0989 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 18978238 Common - S-adenosylmethionine synthetase PF1866 43 COG1812 MetK, Archaeal S-adenosylmethionine synthetase Amino acid transport and metabolism 18976476 Nonpathogen - hypothetical protein PF0104 3 COG0467 RAD55, RecA-superfamily ATPases implicated in signal transduction Signal transduction mechanisms 18976428 Common - putative carbohydrate binding protein PF0056 29 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 18977235 Common - hypothetical protein PF0863 33 COG1437 CyaB, Adenylate cyclase, class 2 (thermophilic) Nucleotide transport and metabolism 18976521 Common - short chain dehydrogenase PF0149 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 18977585 Common - oligopeptide ABC transporter PF1213 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 18978019 Common - DNA-directed RNA polymerase subunit D PF1647 49 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 18977612 Common - putative purine permease PF1240 127 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 18977213 Nonpathogen - hypothetical protein PF0841 2 COG2266 COG2266, GTP:adenosylcobinamide-phosphate guanylyltransferase Coenzyme metabolism 18976480 Common - L-fuculose phosphate aldolase PF0108 158 COG0235 AraD, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases Carbohydrate transport and metabolism 33359497 Nonpathogen - hypothetical protein PF0670.1n 1 None None None 18977331 Nonpathogen - hypothetical protein PF0959 1 None None None 18977324 Nonpathogen - hypothetical protein PF0952 2 COG3889 COG3889, Predicted solute binding protein General function prediction only 33359577 Common - hypothetical protein PF1859 39 COG1437 CyaB, Adenylate cyclase, class 2 (thermophilic) Nucleotide transport and metabolism 18976956 Common - hypothetical protein PF0584 28 COG1695 COG1695, Predicted transcriptional regulators Transcription 18977773 Common - peptidyl-prolyl cis-trans isomerase PF1401 136 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 18976910 Nonpathogen - hypothetical protein PF0538 2 None None None 18976965 Nonpathogen - hypothetical protein PF0593 17 COG2248 COG2248, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 18976659 Common - pyrolysin PF0287 104 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 18977889 Nonpathogen purP 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase PF1517 21 COG1759 COG1759, ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases) General function prediction only 18976960 Common - phospho-sugar mutase PF0588 243 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 18976848 Common - competence damage-inducible protein A PF0476 158 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 18977770 Nonpathogen - hypothetical protein PF1398 3 None None None 33359460 Nonpathogen - hypothetical protein PF0226.1n 1 None None None 18978010 Common - hypothetical protein PF1638 70 COG1355 COG1355, Predicted dioxygenase General function prediction only 18976625 Nonpathogen rps24e 30S ribosomal protein S24e PF0253 32 COG2004 RPS24A, Ribosomal protein S24E Translation, ribosomal structure and biogenesis 18977136 Common - DEXX-box atpase PF0764 32 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 33359521 Nonpathogen - hypothetical protein PF0884.1n 1 None None None 18976675 Common - hypothetical protein PF0303 41 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 18977680 Nonpathogen - hypothetical protein PF1308 2 None None None 18977955 Common - protease iv PF1583 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 18978355 Nonpathogen - hypothetical protein PF1983 2 None None None 18977849 Common - methylmalonyl-CoA mutase PF1477 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 18976642 Common alaS alanyl-tRNA synthetase PF0270 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 18977034 Nonpathogen - hypothetical protein PF0662 1 None None None 18977045 Common - putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit PF0673 211 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 18976881 Nonpathogen - integral membrane glycosyltransferase PF0509 2 None None None 18977602 Nonpathogen - putative atpase PF1230 3 None None None 18978084 Nonpathogen - hypothetical protein PF1712 7 None None None 18977900 Common - imidazoleglycerol-phosphate synthase, PF1528 85 COG0311 PDX2, Predicted glutamine amidotransferase involved in pyridoxine biosynthesis Coenzyme metabolism 18977006 Common - DEXX-box atpase PF0634 33 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 18978169 Common - d-nopaline dehydrogenase PF1797 22 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 18978432 Common - hypothetical protein PF2060 15 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 18978078 Common - tryptophan synthase subunit beta PF1706 228 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 18978348 Common - L-aspartate oxidase PF1976 227 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 18976753 Nonpathogen - hypothetical protein PF0381 2 None None None 18977287 Nonpathogen - hypothetical protein PF0915 9 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 18977154 Nonpathogen - hypothetical protein PF0782 3 None None None 18977609 Nonpathogen - hypothetical protein PF1237 8 COG1504 COG1504, Uncharacterized conserved protein Function unknown 18977407 Nonpathogen - 50S ribosomal protein L21e PF1035 34 COG2139 RPL21A, Ribosomal protein L21E Translation, ribosomal structure and biogenesis 18976634 Common - mfs transporter PF0262 65 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 18977315 Nonpathogen - hypothetical protein PF0943 9 COG2250 COG2250, Uncharacterized conserved protein related to C-terminal domain of eukaryotic chaperone, SACSIN Function unknown 33359517 Common - btpA family protein PF0860 42 COG0434 SgcQ, Predicted TIM-barrel enzyme General function prediction only 18976568 Common - glucose-6-phosphate isomerase PF0196 18 COG2140 COG2140, Thermophilic glucose-6-phosphate isomerase and related metalloenzymes Carbohydrate transport and metabolism / General function prediction only 18976649 Nonpathogen - hypothetical protein PF0277 2 None None None 18976789 Common - hypothetical protein PF0417 67 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 18977694 Common - hypothetical protein PF1322 33 COG1598 COG1598, Uncharacterized conserved protein Function unknown 18977980 Nonpathogen - hypothetical protein PF1608 4 COG4003 COG4003, Uncharacterized protein conserved in archaea Function unknown 18976683 Nonpathogen - hypothetical protein PF0311 2 None None None 18978097 Common - DNA primase PF1725 39 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 18978372 Common - glycine dehydrogenase subunit 2 PF2000 174 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 161484707 Common - 2-isopropylmalate synthase PF1678 211 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 18976527 Common asnC asparaginyl-tRNA synthetase PF0155 249 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 18978178 Nonpathogen rpl19e 50S ribosomal protein L19e PF1806 34 COG2147 RPL19A, Ribosomal protein L19E Translation, ribosomal structure and biogenesis 18976791 Nonpathogen - hypothetical protein PF0419 1 None None None 18977192 Common - cytidylate kinase PF0820 38 COG1102 Cmk, Cytidylate kinase Nucleotide transport and metabolism 18978006 Nonpathogen - hypothetical protein PF1634 6 None None None 18978090 Nonpathogen - hypothetical protein PF1718 35 COG0731 COG0731, Fe-S oxidoreductases Energy production and conversion 18977416 Nonpathogen - hypothetical protein PF1044 7 COG4345 COG4345, Uncharacterized protein conserved in archaea Function unknown 18976855 Nonpathogen - hypothetical protein PF0483 3 None None None 18976841 Nonpathogen - hypothetical protein PF0469 12 COG2411 COG2411, Uncharacterized conserved protein Function unknown 18978365 Nonpathogen rplP0 acidic ribosomal protein P0 PF1993 34 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 18978069 Common - putative ribose/galactose ABC transporter PF1697 104 COG4603 COG4603, ABC-type uncharacterized transport system, permease component General function prediction only 18978423 Nonpathogen - arsr family transcriptional regulator PF2051 3 COG0640 ArsR, Predicted transcriptional regulators Transcription 18978044 Nonpathogen - hypothetical protein PF1672 17 COG2454 COG2454, Uncharacterized conserved protein Function unknown 18977877 Nonpathogen - hypothetical protein PF1505 3 None None None 33359502 Nonpathogen - hypothetical protein PF0732.2n 1 None None None 18976903 Common - cobalamin biosynthesis protein m PF0531 78 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 18977504 Common - putative carbamoyl transferase PF1132 52 COG2192 COG2192, Predicted carbamoyl transferase, NodU family Posttranslational modification, protein turnover, chaperones 18977070 Nonpathogen - hypothetical protein PF0698 2 None None None 18976709 Nonpathogen - flagellin PF0337 6 COG1681 FlaB, Archaeal flagellins Cell motility and secretion 18976873 Nonpathogen - gtpase domain, related to era and thdf PF0501 23 COG1618 COG1618, Predicted nucleotide kinase Nucleotide transport and metabolism 18976434 Common - riboflavin-specific deaminase PF0062 221 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 18977079 Nonpathogen - hypothetical protein PF0707 3 COG1942 COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog General function prediction only 18978305 Common - putative sugar transport ATP-hydrolyzing PF1933 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 18976481 Common - hypothetical protein PF0109 107 COG2962 RarD, Predicted permeases General function prediction only 18978056 Common - acetylglutamate kinase PF1684 188 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 33359552 Nonpathogen - hypothetical protein PF1226 1 None None None 18977111 Common - transcriptional regulatory protein, asnC family PF0739 47 COG1522 Lrp, Transcriptional regulators Transcription 33359593 Nonpathogen - hypothetical protein PF2054.1n 2 None None None 18976895 Nonpathogen - hypothetical protein PF0523 4 COG1617 COG1617, Uncharacterized conserved protein Function unknown 18976587 Common eno phosphopyruvate hydratase PF0215 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 18977368 Nonpathogen - hypothetical protein PF0996 5 COG1627 COG1627, Uncharacterized protein conserved in archaea Function unknown 18976385 Common - transposase PF0013 26 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18977864 Common - glycine cleavage system protein H PF1492 186 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 18976813 Common - galactose-1-phosphate uridylyltransferase PF0441 78 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 18978023 Common - hypothetical protein PF1651 110 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 18977597 Nonpathogen - hypothetical protein PF1225 1 None None None 18977944 Nonpathogen - hypothetical protein PF1572 21 COG2150 COG2150, Predicted regulator of amino acid metabolism, contains ACT domain General function prediction only 18976644 Common - alpha-amylase PF0272 22 COG1449 COG1449, Alpha-amylase/alpha-mannosidase Carbohydrate transport and metabolism 18976654 Common - hypothetical protein PF0282 41 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 18977088 Common - 3-hydroxyisobutyrate dehydrogenase PF0716 172 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 18976774 Common - UDP- or dTTP-glucose 4-epimerase or 4-6-dehydratase PF0402 235 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 18976780 Common - transposase PF0408 26 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18976765 Nonpathogen - hypothetical protein PF0393 17 COG1583 COG1583, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 18977065 Common - hypothetical protein PF0693 5 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 18977447 Common - hypothetical protein PF1075 185 COG0730 COG0730, Predicted permeases General function prediction only 18976722 Common - putative cation antiporter PF0350 122 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 18977344 Common - hypothetical protein PF0972 213 COG3425 PksG, 3-hydroxy-3-methylglutaryl CoA synthase Lipid metabolism 18977270 Common - transposase PF0898 22 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18977909 Nonpathogen - hypothetical protein PF1537 3 None None None 18977992 Nonpathogen - hypothetical protein PF1620 2 None None None 33359465 Nonpathogen - hypothetical protein PF0284 21 COG2150 COG2150, Predicted regulator of amino acid metabolism, contains ACT domain General function prediction only 18978248 Common - hypothetical protein PF1876 11 COG4720 COG4720, Predicted membrane protein Function unknown 18977884 Nonpathogen - hypothetical protein PF1512 2 None None None 18978282 Common - putative oxidoreductase PF1910 237 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 33359456 Nonpathogen - V-type ATP synthase subunit H PF0176 1 COG1638 DctP, TRAP-type C4-dicarboxylate transport system, periplasmic component Carbohydrate transport and metabolism 18977643 Nonpathogen - hypothetical protein PF1271 1 None None None 18977170 Common - glycosyl transferase PF0798 160 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 18976417 Nonpathogen - hypothetical protein PF0045 2 COG1822 COG1822, Predicted archaeal membrane protein Function unknown 18977327 Nonpathogen - hypothetical protein PF0955 1 None None None 18977967 Nonpathogen - hypothetical protein PF1595 2 COG2456 COG2456, Uncharacterized conserved protein Function unknown 18976671 Common cobS cobalamin synthase PF0299 99 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 18978171 Nonpathogen - hypothetical protein PF1799 21 COG1422 COG1422, Predicted membrane protein Function unknown 18977539 Common - chromosome segregation protein PF1167 121 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 18977502 Common - hypothetical protein PF1130 13 COG1367 COG1367, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 18977013 Nonpathogen - hypothetical protein PF0641 2 COG1688 COG1688, Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily) DNA replication, recombination, and repair 33359537 Nonpathogen - hypothetical protein PF1085.1n 1 None None None 18977353 Common - hypothetical efflux transport protein PF0981 149 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 18976597 Nonpathogen - hypothetical N-acetyltransferase PF0225 2 None None None 33359495 Nonpathogen - hypothetical protein PF0642 11 COG1857 COG1857, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 33359508 Common - transposase PF0786 10 None None None 18977256 Nonpathogen - hypothetical protein PF0884 2 None None None 18978168 Common - putative polyferredoxin PF1796 17 COG1142 HycB, Fe-S-cluster-containing hydrogenase components 2 Energy production and conversion 18978241 Nonpathogen - hypothetical protein PF1869 30 COG1829 COG1829, Predicted archaeal kinase (sugar kinase superfamily) General function prediction only 18976979 Nonpathogen - hypothetical protein PF0607 2 None None None 18977388 Common - 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase PF1016 180 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 18976402 Common - hypothetical protein PF0030 37 COG3367 COG3367, Uncharacterized conserved protein Function unknown 18977775 Common - hypothetical protein PF1403 23 COG1901 COG1901, Uncharacterized conserved protein Function unknown 18977093 Common - hypothetical protein PF0721 32 COG0431 COG0431, Predicted flavoprotein General function prediction only 18978001 Common - hypothetical protein PF1629 88 COG0622 COG0622, Predicted phosphoesterase General function prediction only 18977381 Nonpathogen - hypothetical protein PF1009 2 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 18977322 Nonpathogen - hypothetical protein PF0950 1 None None None 18977915 Common - transcriptional regulatory protein, asnC family PF1543 175 COG1522 Lrp, Transcriptional regulators Transcription 18978401 Nonpathogen - nitrogenase reductase (c-terminus) PF2029 4 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 18977218 Common - hypothetical protein PF0846 112 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 18977926 Nonpathogen - hypothetical protein PF1554 2 None None None 18976803 Common - phosphoribosylaminoimidazole synthetase PF0431 232 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 18977364 Common - hypothetical protein PF0992 37 COG2064 TadC, Flp pilus assembly protein TadC Cell motility and secretion / Intracellular trafficking and secretion 18977101 Common - multi domain protein containing corrinoid/iron-sulfur region PF0729 46 COG1456 CdhE, CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) Energy production and conversion 18978437 Common - putative aminopeptidase PF2065 62 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 18977289 Nonpathogen - hypothetical protein PF0917 2 None None None 18977346 Common - hypothetical protein PF0974 61 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 18977552 Common - threonine synthase PF1180 223 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 18977094 Common - alkyl hydroperoxide reductase subunit c PF0722 220 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 18977731 Common - glycosyl transferase PF1359 211 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 18977736 Common - hypothetical protein PF1364 228 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 18977512 Common - translation initiation factor IF-2 subunit alpha PF1140 204 COG1093 SUI2, Translation initiation factor 2, alpha subunit (eIF-2alpha) Translation, ribosomal structure and biogenesis 18978047 Common - putative aspartate racemase PF1675 76 COG1794 RacX, Aspartate racemase Cell envelope biogenesis, outer membrane 18977430 Common - hypothetical protein PF1058 70 COG1213 COG1213, Predicted sugar nucleotidyltransferases Cell envelope biogenesis, outer membrane 18978291 Common - putative dehydrogenase PF1919 187 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 18977145 Nonpathogen - hypothetical protein PF0773 1 None None None 18977898 Nonpathogen - hypothetical protein PF1526 1 None None None 18978335 Common ubiA prenyltransferase UbiA-like protein PF1963 58 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 18977710 Common - transcriptional activator, putative PF1338 76 COG0819 TenA, Putative transcription activator Transcription 18976679 Common - glycosyltransferase PF0307 219 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 18976784 Common - hypothetical protein PF0412 224 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 18976412 Common - type II phosphatidic acid phosphatase PF0040 37 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 18977782 Common - dipeptide transport system permease protein PF1410 218 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 18978224 Common - putative glutamate synthase subunit beta PF1852 212 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 18978008 Common - acetylglutamate kinase, putative PF1636 61 COG1608 COG1608, Predicted archaeal kinase General function prediction only 18976711 Common - methyltransferase PF0339 99 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 18977613 Common upp uracil phosphoribosyltransferase PF1241 164 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 18977402 Common metG methionyl-tRNA synthetase PF1030 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 18977161 Nonpathogen - hypothetical protein PF0789 3 None None None 18977700 Common - ferredoxin--NADP(+) reductase subunit alpha PF1328 89 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 18977952 Nonpathogen - hypothetical protein PF1580 33 COG1094 COG1094, Predicted RNA-binding protein (contains KH domains) General function prediction only 18977824 Common - putative monovalent cation/H+ antiporter subunit F PF1452 81 COG2212 MnhF, Multisubunit Na+/H+ antiporter, MnhF subunit Inorganic ion transport and metabolism 18977307 Common - acetolactate synthase PF0935 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 18977628 Nonpathogen - hypothetical protein PF1256 2 None None None 18976498 Common - DNA repair protein rad25 PF0126 232 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 18976793 Nonpathogen purP hypothetical protein PF0421 20 COG1759 COG1759, ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases) General function prediction only 18977377 Common - hypothetical protein PF1005 32 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 18977441 Nonpathogen - 30S ribosomal protein S8e PF1069 34 COG2007 RPS8A, Ribosomal protein S8E Translation, ribosomal structure and biogenesis 18976574 Common - isocitrate dehydrogenase PF0202 222 COG0538 Icd, Isocitrate dehydrogenases Energy production and conversion 18977242 Nonpathogen - hypothetical protein PF0870 2 None None None 33359563 Nonpathogen - hypothetical protein PF1417 1 None None None 18976839 Common - ATP-dependent protease LA PF0467 204 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 18977211 Common - hypothetical protein PF0839 6 COG1848 COG1848, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 18977525 Common - putative monovalent cation/H+ antiporter subunit E PF1153 62 COG1863 MnhE, Multisubunit Na+/H+ antiporter, MnhE subunit Inorganic ion transport and metabolism 18978266 Nonpathogen - signal recognition particle protein Srp19 PF1894 16 COG1400 SEC65, Signal recognition particle 19 kDa protein Intracellular trafficking and secretion 18976552 Common - V-type ATP synthase subunit C PF0180 31 COG1527 NtpC, Archaeal/vacuolar-type H+-ATPase subunit C Energy production and conversion 18977767 Common - hypothetical protein PF1395 53 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 18978368 Common dcd deoxycytidine triphosphate deaminase PF1996 153 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 18976487 Common - proteasome-activating nucleotidase PF0115 249 COG1222 RPT1, ATP-dependent 26S proteasome regulatory subunit Posttranslational modification, protein turnover, chaperones 33359581 Nonpathogen - hypothetical protein PF1896.1n 1 None None None 18976566 Common - dipeptide ABC transporter, ATP-binding protein PF0194 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 18978102 Common tdk thymidylate kinase PF1730 241 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 18978320 Common - hypothetical protein PF1948 93 COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins Amino acid transport and metabolism / General function prediction only 18977188 Common - hypothetical protein PF0816 194 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 18976546 Common secD preprotein translocase subunit SecD PF0174 114 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 18977879 Common - hypothetical cell division protein ftsZ PF1507 211 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 18977747 Common - elongation factor 1-alpha PF1375 249 COG5256 TEF1, Translation elongation factor EF-1alpha (GTPase) Translation, ribosomal structure and biogenesis 33359540 Nonpathogen - hypothetical protein PF1098 16 COG1590 COG1590, Uncharacterized conserved protein Function unknown 18977870 Common - hypothetical protein PF1498 24 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 18976889 Common - methanol dehydrogenase regulatory protein PF0517 179 COG0714 COG0714, MoxR-like ATPases General function prediction only 18977260 Nonpathogen - hypothetical protein PF0888 2 None None None 18977050 Nonpathogen - hypothetical protein PF0678 12 COG2419 COG2419, Uncharacterized conserved protein Function unknown 18977722 Nonpathogen - hypothetical protein PF1350 9 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 18978253 Nonpathogen - chromatin protein PF1881 28 COG1581 Ssh10b, Archaeal DNA-binding protein Transcription 18978357 Common - hypothetical protein PF1985 19 COG2452 COG2452, Predicted site-specific integrase-resolvase DNA replication, recombination, and repair 18977471 Common - putative formamidase (formamide amidohydrolase) PF1099 64 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 18977494 Nonpathogen - hypothetical protein PF1122 14 COG1857 COG1857, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 33359483 Nonpathogen - hypothetical protein PF0524 4 COG3609 COG3609, Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain Transcription 18978109 Nonpathogen - hypothetical protein PF1737 2 None None None 18978186 Common rpl14p 50S ribosomal protein L14P PF1814 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 18977302 Nonpathogen - hypothetical protein PF0930 29 COG1634 COG1634, Uncharacterized Rossmann fold enzyme General function prediction only 18977934 Common - DNA-directed RNA polymerase subunit A'' PF1562 204 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 18977223 Common - iron-dependent repressor PF0851 101 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 18977293 Common - putative ABC transporter PF0921 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 161484713 Common - hydroxylamine reductase PF0692 74 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 18978258 Common - sugar kinase PF1886 202 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 18977486 Common - orotidine 5'-phosphate decarboxylase PF1114 205 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 18976519 Nonpathogen - potassium channel related protein PF0147 19 COG3273 COG3273, Uncharacterized conserved protein Function unknown 18977066 Common - flavoprotein PF0694 91 COG0426 FpaA, Uncharacterized flavoproteins Energy production and conversion 18977534 Nonpathogen - hypothetical protein PF1162 1 None None None 18976745 Common - putative ABC transporter, periplasmic binding protein PF0373 103 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 18977671 Common - pyrrolidone-carboxylate peptidase PF1299 58 COG2039 Pcp, Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase) Posttranslational modification, protein turnover, chaperones 18976736 Common - tyrosine-protein kinase PF0364 58 COG0478 COG0478, RIO-like serine/threonine protein kinase fused to N-terminal HTH domain Signal transduction mechanisms 18977709 Common - transcriptional activator, putative PF1337 51 COG0819 TenA, Putative transcription activator Transcription 18976528 Nonpathogen - oligosaccharyl transferase stt3 subunit related protein PF0156 21 COG1287 COG1287, Uncharacterized membrane protein, required for N-linked glycosylation General function prediction only 18978158 Nonpathogen - hypothetical protein PF1786 2 None None None 18976832 Nonpathogen - hypothetical protein PF0460 2 COG1361 COG1361, S-layer domain Cell envelope biogenesis, outer membrane 18978329 Common - agmatinase PF1957 144 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 18978214 Nonpathogen - hypothetical protein PF1842 5 COG1354 COG1354, Uncharacterized conserved protein Function unknown 18977128 Common - transposase PF0756 25 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18977026 Nonpathogen - hypothetical protein PF0654 26 None None None 18977200 Common - n-type ATP pyrophosphatase superfamily PF0828 53 COG2102 COG2102, Predicted ATPases of PP-loop superfamily General function prediction only 18977959 Common - hypothetical protein PF1587 40 COG1578 COG1578, Uncharacterized conserved protein Function unknown 18976458 Common - partial alanyl-tRNA synthetase matches COOH terminus PF0086 211 COG2872 COG2872, Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain General function prediction only 18977269 Nonpathogen - hypothetical protein PF0897 1 None None None 18977476 Common - homoserine dehydrogenase PF1104 217 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 18977760 Common - hypothetical protein PF1388 84 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 18977697 Common - hypothetical protein PF1325 87 COG1814 COG1814, Uncharacterized membrane protein Function unknown 18977059 Nonpathogen - hypothetical transcription initiation factor IIB chain b PF0687 34 COG1405 SUA7, Transcription initiation factor TFIIIB, Brf1 subunit/Transcription initiation factor TFIIB Transcription 18977207 Common - daunorubicin resistance ATP-binding protein drrA PF0835 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 18976539 Common - metalloprotease PF0167 54 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 18977298 Nonpathogen - hypothetical protein PF0926 1 None None None 33359452 Nonpathogen - hypothetical protein PF0131.2n 2 None None None 18977649 Common - hypothetical protein PF1277 71 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 161484709 Common - NAD-dependent deacetylase PF1154 152 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 18976693 Common - related to inosine monophosphate dehydrogenase PF0321 213 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 18977594 Nonpathogen - hypothetical protein PF1222 6 COG1753 COG1753, Uncharacterized conserved protein Function unknown 33359488 Common - mannosyl-3-phosphoglycerate phosphatase PF0590 29 COG3769 COG3769, Predicted hydrolase (HAD superfamily) General function prediction only 18976500 Nonpathogen - hypothetical protein PF0128 4 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 18976967 Nonpathogen - diphthine synthase PF0595 34 COG1798 DPH5, Diphthamide biosynthesis methyltransferase Translation, ribosomal structure and biogenesis 18977333 Nonpathogen - hypothetical protein PF0961 1 None None None 18977996 Nonpathogen - hypothetical protein PF1624 8 COG3371 COG3371, Predicted membrane protein Function unknown 18977398 Common - malate oxidoreductase (malic enzyme) PF1026 202 COG0281 SfcA, Malic enzyme Energy production and conversion 18977860 Nonpathogen - hypothetical protein PF1488 4 COG1851 COG1851, Uncharacterized conserved protein Function unknown 18978003 Common - NDP-sugar dehydrogenase PF1631 207 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 18978233 Common - endo-1,4-beta-glucanase-like protein PF1861 89 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 18977907 Common - alpha-glucan phosphorylase PF1535 150 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 33359579 Nonpathogen - putative ABC transporter PF1884 5 COG0392 COG0392, Predicted integral membrane protein Function unknown 18976636 Common hisS histidyl-tRNA synthetase PF0264 249 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 18976912 Common thyX FAD-dependent thymidylate synthase PF0540 73 COG1351 THY1, Predicted alternative thymidylate synthase Nucleotide transport and metabolism 18977190 Common - aminohydrolase PF0818 157 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 18977814 Common - NADH dehydrogenase subunit D PF1442 191 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 18976954 Common - daunorubicin resistance membrane protein PF0582 192 COG1511 COG1511, Predicted membrane protein Function unknown 18977844 Common - aspartate/serine transaminase PF1472 184 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 18978268 Common - l-isoaspartyl protein carboxyl methyltransferase PF1896 80 COG2519 GCD14, tRNA(1-methyladenosine) methyltransferase and related methyltransferases Translation, ribosomal structure and biogenesis 18978082 Common - anthranilate phosphoribosyltransferase PF1710 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 18976602 Common - transcriptional regulatory protein, arsR family PF0230 12 COG1777 COG1777, Predicted transcriptional regulators Transcription 18978195 Common rplW 50S ribosomal protein L23 PF1823 206 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 18978212 Nonpathogen - hypothetical protein PF1840 2 None None None 18977957 Common - hypothetical protein PF1585 106 COG0628 PerM, Predicted permease General function prediction only 18976779 Nonpathogen - hypothetical protein PF0407 4 None None None 18977138 Common - putative dehydrogenase PF0766 193 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 18976408 Common - daunorubicin resistance membrane protein PF0036 112 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 18977804 Common - mbh10 NADH dehydrogenase subunit PF1432 192 COG3260 COG3260, Ni,Fe-hydrogenase III small subunit Energy production and conversion 18977313 Common - putative alpha-isopropylmalate/homocitrate synthase family transferase PF0941 212 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 18977199 Common - putative RNA methyltransferase PF0827 202 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 18977008 Common - DEXX-box atpase PF0636 33 COG1672 COG1672, Predicted ATPase (AAA+ superfamily) General function prediction only 18977175 Common - hypothetical protein PF0803 69 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 18976623 Common - hypothetical protein PF0251 121 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 18977592 Common - hypothetical sulfate adenylyltransferase PF1220 39 COG2046 MET3, ATP sulfurylase (sulfate adenylyltransferase) Inorganic ion transport and metabolism 18978327 Nonpathogen - hypothetical protein PF1955 2 None None None 18977085 Nonpathogen - hypothetical protein PF0713 1 None None None 18976441 Common - transposase PF0069 25 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18977785 Nonpathogen - hypothetical protein PF1413 2 COG3431 COG3431, Predicted membrane protein Function unknown 18976917 Nonpathogen - hypothetical protein PF0545 1 None None None 18977847 Nonpathogen rpl40e 50S ribosomal protein L40e PF1475 26 COG1552 RPL40A, Ribosomal protein L40E Translation, ribosomal structure and biogenesis 18978273 Common - oxygen-independent coproporphyrinogen III oxidase PF1901 80 COG1243 ELP3, Histone acetyltransferase Transcription / Chromatin structure and dynamics 18976787 Nonpathogen - dehydrogenase PF0415 3 None None None 18978034 Common - 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase PF1662 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 18976731 Common - oligopeptide ABC transport system permease PF0359 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 18978145 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit gamma PF1773 62 COG1014 PorG, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit Energy production and conversion 33359523 Nonpathogen - hypothetical protein PF0897.1n 1 None None None 18976927 Common - hypothetical protein PF0555 3 None None None 18977631 Nonpathogen - hypothetical protein PF1259 1 None None None 18977540 Nonpathogen - hypothetical protein PF1168 4 COG1630 COG1630, Uncharacterized protein conserved in archaea Function unknown 18977862 Common - hypothetical protein PF1490 79 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 18977478 Common - hypothetical protein PF1106 127 COG0628 PerM, Predicted permease General function prediction only 18978419 Common - l-asparaginase PF2047 147 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 18976856 Nonpathogen - hypothetical translation elongation factor EF-Tu PF0484 15 COG1100 COG1100, GTPase SAR1 and related small G proteins General function prediction only 18977769 Common - hypothetical protein PF1397 110 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 18978140 Common - 2-oxoglutarate ferredoxin oxidoreductase subunit alpha PF1768 112 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 18976478 Nonpathogen - hypothetical protein PF0106 22 COG1784 COG1784, Predicted membrane protein Function unknown 18977529 Common - hypothetical protein PF1157 35 COG1824 COG1824, Permease, similar to cation transporters Inorganic ion transport and metabolism 18977654 Common - rubredoxin PF1282 123 COG1773 COG1773, Rubredoxin Energy production and conversion 18978123 Common - putative solute binding lipoprotein PF1751 142 COG4143 TbpA, ABC-type thiamine transport system, periplasmic component Coenzyme metabolism 18976901 Nonpathogen - hypothetical protein PF0529 6 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 18977418 Common - queuine trna-ribosyltransferase PF1046 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 18976523 Nonpathogen - hypothetical protein PF0151 2 None None None 18976837 Common - putative glycosyl transferase PF0465 222 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 18977979 Common - thymidine phosphorylase PF1607 132 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 18976879 Nonpathogen - hypothetical protein PF0507 1 None None None 18976426 Common - transcriptional regulatory protein, asnC family PF0054 163 COG1522 Lrp, Transcriptional regulators Transcription 18977610 Common - putative ABC transporter PF1238 249 COG2401 COG2401, ABC-type ATPase fused to a predicted acetyltransferase domain General function prediction only 18976510 Nonpathogen - hypothetical protein PF0138 4 COG1633 COG1633, Uncharacterized conserved protein Function unknown 18977272 Common - hypothetical protein PF0900 6 COG1403 McrA, Restriction endonuclease Defense mechanisms 18976862 Nonpathogen - hypothetical protein PF0490 9 COG4044 COG4044, Uncharacterized protein conserved in archaea Function unknown 18978054 Common - ribosomal protein s6 modification protein PF1682 94 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 18977455 Nonpathogen - hypothetical protein PF1083 7 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 18978341 Common - sugar ABC transporter, permease protein PF1969 187 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 18977237 Common - aromatic acid decarboxylase PF0865 153 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 18977581 Common - oligopeptide ABC transporter PF1209 196 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 18977468 Common ileS isoleucyl-tRNA synthetase PF1096 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 18977018 Common - hypothetical protein PF0646 16 COG2105 COG2105, Uncharacterized conserved protein Function unknown 33359504 Nonpathogen - hypothetical protein PF0738.1n 1 None None None 33359467 Nonpathogen - hypothetical protein PF0315 9 COG1772 COG1772, Uncharacterized protein conserved in archaea Function unknown 33359554 Nonpathogen - hypothetical protein PF1247.1n 1 None None None 18976436 Common - bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein PF0064 231 COG0807 RibA, GTP cyclohydrolase II Coenzyme metabolism 18977578 Nonpathogen - hypothetical protein PF1206 2 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 18976869 Nonpathogen - hypothetical protein PF0497 2 COG1414 IclR, Transcriptional regulator Transcription 18977263 Common - sulfhydrogenase beta subunit PF0891 31 None None None 18977558 Common - NADH oxidase PF1186 244 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 18976612 Common - hypothetical protein PF0240 46 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 18976798 Common - phosphoribosylaminoimidazole carboxylase ATPase subunit PF0426 198 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 18976700 Nonpathogen - hypothetical protein PF0328 3 None None None 18978059 Nonpathogen - hypothetical protein PF1687 2 None None None 18976952 Nonpathogen - hypothetical protein PF0580 1 None None None 18978219 Common - tbp-interacting protein tip49 PF1847 21 COG1224 TIP49, DNA helicase TIP49, TBP-interacting protein Transcription 18977086 Common - hypothetical protein PF0714 26 COG0716 FldA, Flavodoxins Energy production and conversion 18977063 Nonpathogen - hypothetical protein PF0691 5 COG2522 COG2522, Predicted transcriptional regulator General function prediction only 33359530 Nonpathogen - hypothetical protein PF0964 9 None None None 18977056 Nonpathogen - hypothetical protein PF0684 1 None None None 18976893 Common - hypothetical protein PF0521 68 COG2119 COG2119, Predicted membrane protein Function unknown 18977545 Common - hypothetical protein PF1173 30 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 18978029 Common - histidyl-tRNA synthetase PF1657 78 COG3705 HisZ, ATP phosphoribosyltransferase involved in histidine biosynthesis Amino acid transport and metabolism 18976776 Common - hypothetical protein PF0404 83 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 18977564 Nonpathogen - hypothetical protein PF1192 30 COG1633 COG1633, Uncharacterized conserved protein Function unknown 18977970 Common - dCMP deaminase PF1598 96 COG2131 ComEB, Deoxycytidylate deaminase Nucleotide transport and metabolism 18978133 Nonpathogen - hypothetical protein PF1761 4 COG2247 LytB, Putative cell wall-binding domain Cell envelope biogenesis, outer membrane 18977946 Common - hypothetical protein PF1574 158 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 18977682 Nonpathogen - hypothetical protein PF1310 1 None None None 18977990 Common - ATP-binding protein phnp PF1618 63 COG1235 PhnP, Metal-dependent hydrolases of the beta-lactamase superfamily I General function prediction only 18976975 Common - hypothetical protein PF0603 46 COG1656 COG1656, Uncharacterized conserved protein Function unknown 18976646 Common - transposase PF0274 25 COG3316 COG3316, Transposase and inactivated derivatives DNA replication, recombination, and repair 18976707 Nonpathogen - flagella-related protein d, putative PF0335 9 COG3351 FlaD, Putative archaeal flagellar protein D/E Cell motility and secretion 18978246 Common - glyceraldehyde-3-phosphate dehydrogenase PF1874 69 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 18977569 Common - NADH oxidase /nitrite reductase PF1197 212 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 18977987 Common - hypothetical protein PF1615 117 COG1690 RtcB, Uncharacterized conserved protein Function unknown 18977463 Nonpathogen - hypothetical protein PF1091 1 None None None 18977893 Common - formate dehydrogenase alpha chain PF1521 202 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 18978064 Common aroD 3-dehydroquinate dehydratase PF1692 56 COG0710 AroD, 3-dehydroquinate dehydratase Amino acid transport and metabolism 18978162 Common - transcriptional regulatory protein arsR family PF1790 34 COG1777 COG1777, Predicted transcriptional regulators Transcription 18976751 Nonpathogen rpl39e 50S ribosomal protein L39e PF0379 9 COG2167 RPL39, Ribosomal protein L39E Translation, ribosomal structure and biogenesis 18976747 Nonpathogen - prefoldin subunit alpha PF0375 17 COG1730 GIM5, Predicted prefoldin, molecular chaperone implicated in de novo protein folding Posttranslational modification, protein turnover, chaperones 18976472 Common - molybdopterin converting factor subunit 2 PF0100 159 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 18978138 Common - signal recognition particle receptor PF1766 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 18976816 Common - hydrolase PF0444 27 COG1543 COG1543, Uncharacterized conserved protein Function unknown 33359565 Nonpathogen - hypothetical protein PF1439 9 COG4818 COG4818, Predicted membrane protein Function unknown 18978421 Common - hypothetical protein PF2049 39 COG2339 COG2339, Predicted membrane protein Function unknown 18977001 Nonpathogen - hypothetical protein PF0629 1 COG1782 COG1782, Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain General function prediction only 18976716 Common - tungsten-containing aldehyde ferredoxin oxidoreductase cofactor modifying protein PF0344 124 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 18978374 Common - sucrose transport protein PF2002 31 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 18976554 Common - V-type ATP synthase subunit A PF0182 247 COG1155 NtpA, Archaeal/vacuolar-type H+-ATPase subunit A Energy production and conversion 18978071 Common - 3-phosphoshikimate 1-carboxyvinyltransferase PF1699 228 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 18977603 Common - transcriptional regulatory protein, asnC family PF1231 170 COG1522 Lrp, Transcriptional regulators Transcription 18978412 Nonpathogen - hypothetical protein PF2040 18 COG1432 COG1432, Uncharacterized conserved protein Function unknown 33359506 Nonpathogen - hypothetical protein PF0776 7 COG4113 COG4113, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 18976887 Nonpathogen - hypothetical protein PF0515 2 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 18976618 Nonpathogen - hypothetical protein PF0246 2 None None None 18977072 Nonpathogen - x-pro dipeptidase, N-terminal fragment PF0700 1 None None None 18978095 Common - hypothetical protein PF1723 220 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 18976376 Nonpathogen - hypothetical protein PF0004 3 None None None 18976628 Common - DNA-directed RNA polymerase subunit E' PF0256 122 COG1095 RPB7, DNA-directed RNA polymerase, subunit E' Transcription 18978088 Nonpathogen - hypothetical protein PF1716 23 COG1412 COG1412, Uncharacterized proteins of PilT N-term./Vapc superfamily General function prediction only 18976828 Common - carboxypeptidase 1 PF0456 82 COG2317 COG2317, Zn-dependent carboxypeptidase Amino acid transport and metabolism 18978428 Nonpathogen rps15p 30S ribosomal protein S15P PF2056 34 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 18976986 Nonpathogen - inosine-5'-monophosphate dehydrogenase related protein III PF0614 18 None None None 33359519 Nonpathogen - hypothetical protein PF0871 2 None None None 18976843 Nonpathogen - hypothetical protein PF0471 5 None None None 18976462 Common moaA molybdenum cofactor biosynthesis protein A PF0090 209 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 18976959 Nonpathogen - hypothetical protein PF0587 1 None None None 18978388 Nonpathogen - preprotein translocase subunit SecG PF2016 2 COG4023 SBH1, Preprotein translocase subunit Sec61beta Intracellular trafficking and secretion