Escherichia coli O157:H7 str. Sakai plasmid pO157, complete sequence NC_002128 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 10955296 Common - transposase pO157p31 149 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 10955286 Common papX PapX pO157p21 14 COG1846 MarR, Transcriptional regulators Transcription 10955332 Pathogen - hypothetical protein pO157p66 2 None None None 10955349 Common tagA ToxR-regulated lipoprotein pO157p01 7 None None None 41223295 Pathogen - hypothetical protein ECp023 1 None None None 10955320 Common nikB NikB pO157p54 8 None None None 10955329 Common - hypothetical protein pO157p63 87 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 41223300 Pathogen - hypothetical protein ECp070 2 None None None 10955303 Pathogen - hypothetical protein pO157p37 2 None None None 10955312 Common - hypothetical protein pO157p46 12 None None None 10955278 Common etpN EptN pO157p13 134 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 10955274 Common etpJ EptJ pO157p09 38 COG4795 PulJ, Type II secretory pathway, component PulJ Intracellular trafficking and secretion 10955330 Common finO fertility inhibition protein pO157p64 7 COG3109 ProQ, Activator of osmoprotectant transporter ProP Signal transduction mechanisms 10955301 Common - reverse transcriptase pO157p35 91 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 10955337 Pathogen - hypothetical protein pO157p71 1 None None None 41223297 Common - hypothetical protein ECp025.2n 7 None None None 10955325 Common - transposase Tra5 pO157p59 26 None None None 10955340 Common - transposase pO157p74 17 None None None 10955288 Pathogen - hypothetical protein pO157p23 1 None None None 10955276 Common etpL EtpL pO157p11 17 COG3297 PulL, Type II secretory pathway, component PulL Intracellular trafficking and secretion 10955310 Pathogen - hypothetical protein pO157p44 1 None None None 10955308 Common klcA KlcA pO157p42 6 None None None 10955323 Common - transposase pO157p57 14 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 10955272 Pathogen etpH EtpH pO157p07 4 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 10955346 Common - RfbU-like protein pO157p80 216 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 10955344 Common espP EspP pO157p78 29 COG4625 COG4625, Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain Function unknown 10955268 Common etpD EtpD pO157p03 141 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 41223299 Common - hypothetical protein ECp054 4 None None None 10955335 Common - hypothetical protein pO157p69 13 COG3905 COG3905, Predicted transcriptional regulator Transcription 10955318 Common psiA PsiA pO157p52 4 None None None 10955316 Common - hypothetical protein pO157p50 85 COG1475 Spo0J, Predicted transcriptional regulators Transcription 41223301 Common - hypothetical protein ECp072 12 None None None 10955281 Common - hypothetical protein pO157p16 143 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 10955277 Common etpM EtpM pO157p12 13 COG3149 PulM, Type II secretory pathway, component PulM Intracellular trafficking and secretion 10955306 Pathogen - hypothetical protein pO157p40 5 None None None 10955291 Common - hypothetical protein pO157p26 2 None None None 10955333 Pathogen repA2 replication protein pO157p67 5 None None None 10955279 Pathogen etpO EptO pO157p14 4 None None None 10955314 Pathogen - hypothetical protein pO157p48 1 None None None 10955321 Common - hypothetical protein pO157p55 10 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 10955275 Common etpK EtpK pO157p10 41 COG3156 PulK, Type II secretory pathway, component PulK Intracellular trafficking and secretion 10955302 Pathogen - hypothetical protein pO157p36 6 None None None 10955293 Pathogen letA LetA pO157p28 5 COG5302 COG5302, Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid General function prediction only 10955313 Common - hypothetical protein pO157p47 25 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 41223296 Common repFIB RepFIB pO157p24 7 None None None 10955295 Common - resolvase pO157p30 173 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 10955331 Common - hypothetica protein pO157p65 90 COG1525 COG1525, Micrococcal nuclease (thermonuclease) homologs DNA replication, recombination, and repair 10955270 Common etpF EtpF pO157p05 146 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 10955328 Common traX TraX pO157p62 11 None None None 10955283 Common hlyA hemolysin A pO157p18 68 COG2931 COG2931, RTX toxins and related Ca2+-binding proteins Secondary metabolites biosynthesis, transport, and catabolism 10955304 Common - hemagglutinin-associated protein pO157p38 115 COG0863 COG0863, DNA modification methylase DNA replication, recombination, and repair 10955287 Common - recombinase pO157p22 82 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 10955336 Common - hypothetical protein pO157p70 13 COG3668 ParE, Plasmid stabilization system protein General function prediction only 10955267 Common etpC EtpC pO157p02 17 COG3031 PulC, Type II secretory pathway, component PulC Intracellular trafficking and secretion 10955285 Common hlyD hemolysin D pO157p20 123 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 41223298 Pathogen - hypothetical protein ECp042 5 None None None 10955348 Common - lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase pO157p82 88 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 10955297 Common - hypothetical protein pO157p83 30 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 10955311 Pathogen - hypothetical protein pO157p45 3 None None None 41223294 Pathogen - hypothetical protein ECp021.1n 1 None None None 10955273 Common etpI EtpI pO157p08 27 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 10955326 Common IS629 hypothetical protein pO157p60 93 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 10955324 Common toxB toxin B pO157p58 5 None None None 10955319 Common parB small toxic polypeptide pO157p53 5 None None None 10955317 Common psiB PsiB pO157p51 4 None None None 10955290 Pathogen - hypothetical protein pO157p25 2 None None None 10955309 Pathogen - hypothetical protein pO157p43 2 None None None 10955322 Common - transposase Tra5 pO157p56 63 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 10955280 Common - hypothetical protein pO157p15 57 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 10955300 Common sopB SopB pO157p34 18 COG1475 Spo0J, Predicted transcriptional regulators Transcription 10955299 Common sopA SopA pO157p33 203 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 10955271 Common etpG EtpG pO157p06 103 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 10955345 Common - hypothetical protein pO157p79 17 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 10955347 Common - hypothetical protein pO157p81 60 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 10955269 Common etpE EtpE pO157p04 224 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 10955334 Common repA1 replication protein pO157p68 8 None None None 10955292 Common - KfrAs pO157p27 4 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 10955315 Common ssb single-strand binding protein pO157p49 213 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 41223302 Common - hypothetical protein ECp088.2c 15 COG3677 COG3677, Transposase and inactivated derivatives DNA replication, recombination, and repair 10955305 Common - hypothetical protein pO157p39 6 None None None 10955284 Common hlyB hemolysin B pO157p19 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 10955282 Common hlyC hemolysin C pO157p17 14 COG2994 HlyC, ACP:hemolysin acyltransferase (hemolysin-activating protein) Posttranslational modification, protein turnover, chaperones 10955307 Pathogen - hypothetical protein pO157p41 2 None None None 10955294 Common letB LetB pO157p29 8 None None None 10955343 Common - transposase pO157p77 148 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair