Salinispora arenicola CNS-205, complete genome NC_009953 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 159037601 Common - CRISPR-associated protein Cas2 Sare_1978 27 None None None 159036160 Common - hypothetical protein Sare_0493 4 None None None 159038863 Common - preprotein translocase, SecG subunit Sare_3322 14 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 159036760 Common - Transketolase domain protein Sare_1114 164 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 159037517 Common - hypothetical protein Sare_1894 9 None None None 159037293 Common - transcriptional regulator, ArsR family Sare_1667 133 COG0640 ArsR, Predicted transcriptional regulators Transcription 159035913 Common - transcriptional regulator, ArsR family Sare_0241 45 COG1777 COG1777, Predicted transcriptional regulators Transcription 159040182 Common - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Sare_4691 182 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 159036253 Common - peptidase S9 prolyl oligopeptidase active site domain protein Sare_0587 100 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 159039205 Common - Na-Ca exchanger/integrin-beta4 Sare_3672 21 None None None 159038951 Common - protein of unknown function DUF161 Sare_3411 25 COG2364 COG2364, Predicted membrane protein Function unknown 159039457 Common - cobyric acid synthase CobQ Sare_3928 153 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 159039574 Common - oxidoreductase domain protein Sare_4046 50 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 159038261 Common - cyclase/dehydrase Sare_2686 4 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 159035681 Common - DNA gyrase, B subunit Sare_0007 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 159038912 Common - DNA polymerase I Sare_3372 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 159035984 Common - FAD linked oxidase domain protein Sare_0316 197 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 159039445 Common - thioesterase superfamily protein Sare_3916 23 COG0824 FcbC, Predicted thioesterase General function prediction only 159037836 Common - Pyruvate dehydrogenase (acetyl-transferring) Sare_2238 154 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 159036184 Common - acyl-CoA dehydrogenase domain protein Sare_0517 160 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159039538 Common - H+transporting two-sector ATPase delta/epsilon subunit Sare_4010 166 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 159036209 Common - spermidine synthase-like protein Sare_0542 34 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 159036882 Common - Rieske (2Fe-2S) domain protein Sare_1239 10 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 159038538 Common - transcriptional regulator, PadR-like family Sare_2975 57 COG1695 COG1695, Predicted transcriptional regulators Transcription 159038157 Common - CRISPR-associated protein, Cse3 family Sare_2577 31 None None None 159036227 Common - transcriptional regulator, AraC family Sare_0560 148 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 159038400 Common - Alcohol dehydrogenase zinc-binding domain protein Sare_2827 169 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 159040503 Common - Rhodanese domain protein Sare_5022 168 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 159040283 Nonpathogen - hypothetical protein Sare_4792 1 None None None 159036069 Common - phosphoglycerate mutase 1 family Sare_0402 152 COG0588 GpmA, Phosphoglycerate mutase 1 Carbohydrate transport and metabolism 159038294 Common - ABC transporter related Sare_2719 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159038562 Common - binding-protein-dependent transport systems inner membrane component Sare_3000 145 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 159037507 Common - acetylornithine and succinylornithine aminotransferase Sare_1884 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 159036971 Nonpathogen - hypothetical protein Sare_1332 1 None None None 159039103 Common - Nitric-oxide synthase Sare_3563 11 COG4362 COG4362, Nitric oxide synthase, oxygenase domain Inorganic ion transport and metabolism / Amino acid transport and metabolism 159038836 Common - protein of unknown function DUF692 Sare_3295 62 COG3220 COG3220, Uncharacterized protein conserved in bacteria Function unknown 159036044 Common - protein of unknown function DUF849 Sare_0377 63 COG3246 COG3246, Uncharacterized conserved protein Function unknown 159037084 Common - hypothetical protein Sare_1447 19 None None None 159038334 Common - hypothetical protein Sare_2761 4 None None None 159036752 Common - aminotransferase class V Sare_1106 224 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 159035851 Common - Extracellular ligand-binding receptor Sare_0178 132 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 159035986 Common - Cysteine desulfurase Sare_0318 216 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 159035959 Common - hypothetical protein Sare_0290 16 None None None 159040444 Common - putative transcriptional regulator, TetR family Sare_4960 10 COG1309 AcrR, Transcriptional regulator Transcription 159036825 Common - SCP-like extracellular Sare_1179 85 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 159038023 Common - NUDIX hydrolase Sare_2432 30 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 159039418 Common - ribose 5-phosphate isomerase Sare_3889 121 COG0698 RpiB, Ribose 5-phosphate isomerase RpiB Carbohydrate transport and metabolism 159038430 Common - hypothetical protein Sare_2860 8 None None None 159036542 Common - LPPG domain containing protein Sare_0886 41 COG0391 COG0391, Uncharacterized conserved protein Function unknown 159037806 Common - hypothetical protein Sare_2207 8 None None None 159037616 Nonpathogen - hypothetical protein Sare_2002 1 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159036340 Common - PHP domain protein Sare_0681 123 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 159040564 Common - hypothetical protein Sare_5084 14 None None None 159035922 Common - DNA polymerase III, subunits gamma and tau Sare_0252 246 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 159035710 Nonpathogen - hypothetical protein Sare_0036 1 None None None 159036086 Nonpathogen - hypothetical protein Sare_0419 2 None None None 159036698 Nonpathogen - hypothetical protein Sare_1051 1 None None None 159037143 Common - Beta-glucosidase Sare_1509 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 159040496 Nonpathogen - hypothetical protein Sare_5015 1 COG5373 COG5373, Predicted membrane protein Function unknown 159038672 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sare_3126 49 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159038873 Nonpathogen - hypothetical protein Sare_3332 1 None None None 159040571 Common - band 7 protein Sare_5091 31 COG2268 COG2268, Uncharacterized protein conserved in bacteria Function unknown 159036778 Common - hypothetical protein Sare_1132 12 None None None 159037476 Common - hypothetical protein Sare_1853 16 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 159037780 Common - hypothetical protein Sare_2180 8 COG0824 FcbC, Predicted thioesterase General function prediction only 159038652 Common - hypothetical protein Sare_3103 8 None None None 159037911 Common - hypothetical protein Sare_2315 9 None None None 159037622 Nonpathogen - hypothetical protein Sare_2008 2 None None None 159036383 Common - dimethyladenosine transferase Sare_0726 239 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 159036834 Common - nitrogen regulatory protein P-II Sare_1188 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 159038903 Common - Integral membrane protein TerC Sare_3363 90 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 159036558 Common - adenosylhomocysteinase Sare_0903 176 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 159040336 Common - phosphotransferase system lactose/cellobiose-specific IIB subunit Sare_4848 41 COG2213 MtlA, Phosphotransferase system, mannitol-specific IIBC component Carbohydrate transport and metabolism 159040428 Nonpathogen - hypothetical protein Sare_4944 1 None None None 159036536 Common - hypothetical protein Sare_0880 13 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159039363 Common - PhoH family protein Sare_3832 199 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 159038573 Nonpathogen - DNA polymerase beta domain protein region Sare_3011 1 None None None 159037715 Common - protein of unknown function DUF1205 Sare_2112 11 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 159035720 Common - NAD-dependent epimerase/dehydratase Sare_0046 223 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 159036099 Common - membrane-bound lytic murein transglycosylase B-like protein Sare_0432 18 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 159037427 Common - protein-export membrane protein SecF Sare_1803 201 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 159037693 Common - transcriptional regulator, AraC family Sare_2090 152 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 159038723 Common - putative transposase Sare_3178 50 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 159037270 Common - Rieske (2Fe-2S) domain protein Sare_1640 46 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 159039295 Nonpathogen - hypothetical protein Sare_3764 1 None None None 159039181 Common - transcriptional regulator, LysR family Sare_3645 112 COG0583 LysR, Transcriptional regulator Transcription 159038193 Common - ribosomal protein L32 Sare_2615 54 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 159037489 Common - response regulator receiver modulated diguanylate cyclase Sare_1866 222 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 159037920 Common - protein of unknown function DUF75 Sare_2324 22 COG2047 COG2047, Uncharacterized protein (ATP-grasp superfamily) General function prediction only 159035686 Nonpathogen - hypothetical protein Sare_0012 1 None None None 159037822 Common - Rhodanese domain protein Sare_2224 154 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 159039922 Common - FAD-linked oxidoreductase Sare_4407 59 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 159036549 Common - protein of unknown function DUF779 Sare_0894 41 COG3564 COG3564, Uncharacterized protein conserved in bacteria Function unknown 159036765 Common - transcriptional regulator, LacI family Sare_1119 126 COG1609 PurR, Transcriptional regulators Transcription 159040537 Common - molybdopterin biosynthesis MoaE protein Sare_5056 43 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 159038224 Common - alpha/beta hydrolase fold Sare_2649 27 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159037331 Common - succinate dehydrogenase or fumarate reductase, flavoprotein subunit Sare_1706 223 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 159040252 Common - protein of unknown function DUF105 Sare_4761 16 COG1865 COG1865, Uncharacterized conserved protein Function unknown 159035777 Common - transcriptional regulator, TetR family Sare_0104 48 COG1309 AcrR, Transcriptional regulator Transcription 159036621 Nonpathogen - hypothetical protein Sare_0971 1 None None None 159039009 Nonpathogen - hypothetical protein Sare_3469 1 None None None 159038923 Nonpathogen - hypothetical protein Sare_3383 1 None None None 159038626 Common - two component transcriptional regulator, winged helix family Sare_3070 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159037128 Common - hypothetical protein Sare_1492 48 COG0122 AlkA, 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase DNA replication, recombination, and repair 159036946 Common - short-chain dehydrogenase/reductase SDR Sare_1307 205 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 159038060 Common - short-chain dehydrogenase/reductase SDR Sare_2479 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159039512 Common - hypothetical protein Sare_3984 77 None None None 159038075 Nonpathogen - regulator of chromosome condensation, RCC1 Sare_2494 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 159038003 Common - FAD dependent oxidoreductase Sare_2408 48 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159035908 Nonpathogen - hypothetical protein Sare_0235 1 None None None 159037057 Common - beta-lactamase Sare_1419 14 COG2367 PenP, Beta-lactamase class A Defense mechanisms 159037463 Common - 3-dehydroquinate synthase Sare_1840 205 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 159038817 Nonpathogen - hypothetical protein Sare_3276 1 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 159037285 Nonpathogen - hypothetical protein Sare_1659 1 None None None 159039708 Common - hypothetical protein Sare_4184 6 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 159039431 Common - 4-oxalocrotonate decarboxylase Sare_3902 67 COG3971 COG3971, 2-keto-4-pentenoate hydratase Secondary metabolites biosynthesis, transport, and catabolism 159038540 Common - regulator of chromosome condensation RCC1 Sare_2977 37 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 159038852 Common - putative transcriptional regulator Sare_3311 18 COG2345 COG2345, Predicted transcriptional regulator Transcription 159039374 Common - aminoglycoside phosphotransferase Sare_3843 6 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 159039676 Common - peptidase U62 modulator of DNA gyrase Sare_4148 37 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 159038801 Common - beta-lactamase domain protein Sare_3260 48 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 159036783 Common - von Willebrand factor type A Sare_1137 78 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 159038547 Nonpathogen - Endonuclease/exonuclease/phosphatase Sare_2985 2 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 159040266 Common - ROK family protein Sare_4775 108 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 159036936 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Sare_1295 17 COG0388 COG0388, Predicted amidohydrolase General function prediction only 159040234 Common - GTP cyclohydrolase I Sare_4743 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 159039933 Common - hypothetical protein Sare_4418 11 None None None 159037537 Common - alanine dehydrogenase Sare_1914 166 COG0686 Ald, Alanine dehydrogenase Amino acid transport and metabolism 159036794 Common - transcriptional regulator, IclR family Sare_1148 106 COG1414 IclR, Transcriptional regulator Transcription 159037576 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Sare_1953 13 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 159038198 Common - periplasmic solute binding protein Sare_2620 147 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 159038129 Common - GCN5-related N-acetyltransferase Sare_2549 13 COG2153 ElaA, Predicted acyltransferase General function prediction only 159040415 Common - Polyprenyl synthetase Sare_4930 229 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 159036167 Nonpathogen - nucleoside phosphorylase-like protein Sare_0500 3 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 159037105 Common - acetyl-CoA acetyltransferase Sare_1469 167 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 159037178 Common - luciferase family protein Sare_1544 53 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 159037543 Common - cytidylate kinase Sare_1920 203 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 159040240 Common - hypothetical protein Sare_4749 27 COG5282 COG5282, Uncharacterized conserved protein Function unknown 159038239 Common - lipolytic protein G-D-S-L family Sare_2664 17 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 159039178 Nonpathogen - major facilitator superfamily MFS_1 Sare_3642 1 None None None 159036465 Common - geranylgeranyl reductase Sare_0808 19 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 159039114 Common - putative transposase Sare_3576 50 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 159038362 Common - copper resistance protein CopC Sare_2789 39 COG2372 CopC, Uncharacterized protein, homolog of Cu resistance protein CopC General function prediction only 159038598 Nonpathogen - hypothetical protein Sare_3038 1 None None None 159040147 Common - CutA1 divalent ion tolerance protein Sare_4654 61 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 159037268 Common - GTP-binding protein HSR1-related Sare_1638 19 COG1159 Era, GTPase General function prediction only 159037730 Common - helix-turn-helix domain protein Sare_2127 6 None None None 159038145 Common - transcriptional regulator, MarR family Sare_2565 70 COG1846 MarR, Transcriptional regulators Transcription 159039000 Common - transglutaminase domain protein Sare_3460 88 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 159039159 Common - Beta-ketoacyl synthase Sare_3623 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159037386 Nonpathogen - hypothetical protein Sare_1761 1 None None None 159036711 Nonpathogen - hypothetical protein Sare_1064 1 None None None 159039565 Common - protein of unknown function DUF305 Sare_4037 28 COG3544 COG3544, Uncharacterized protein conserved in bacteria Function unknown 159037221 Common - IstB domain protein ATP-binding protein Sare_1590 98 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 159036857 Common - putative phiRv2 prophage protein Sare_1212 7 None None None 159036842 Common - 16S rRNA processing protein RimM Sare_1196 175 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 159038640 Nonpathogen - hypothetical protein Sare_3089 4 None None None 159039817 Common - ribosomal protein S5 Sare_4298 247 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 159038822 Common - Methyltransferase type 11 Sare_3281 52 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159038735 Common - hypothetical protein Sare_3190 32 COG4188 COG4188, Predicted dienelactone hydrolase General function prediction only 159038680 Common - hypothetical protein Sare_3134 37 COG4325 COG4325, Predicted membrane protein Function unknown 159040397 Nonpathogen - hypothetical protein Sare_4910 1 None None None 159040583 Nonpathogen - hypothetical protein Sare_5103 4 None None None 159039540 Common - ATP synthase F1, beta subunit Sare_4012 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 159039120 Common - peptidase U61 LD-carboxypeptidase A Sare_3582 78 COG1619 LdcA, Uncharacterized proteins, homologs of microcin C7 resistance protein MccF Defense mechanisms 159037315 Common - glycosyl transferase family 2 Sare_1690 161 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 159038410 Common - Enoyl-CoA hydratase/isomerase Sare_2837 178 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 159037258 Common - Substrate-binding region of ABC-type glycine betaine transport system Sare_1628 57 COG2113 ProX, ABC-type proline/glycine betaine transport systems, periplasmic components Amino acid transport and metabolism 159039477 Common - hypothetical protein Sare_3949 27 COG3211 PhoX, Predicted phosphatase General function prediction only 159037675 Common - amino acid adenylation domain Sare_2071 215 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159036551 Common - putative phytochrome sensor protein Sare_0896 71 COG3284 AcoR, Transcriptional activator of acetoin/glycerol metabolism Secondary metabolites biosynthesis, transport, and catabolism / Transcription 159037636 Common - O-methyltransferase family 2 Sare_2028 35 None None None 159037774 Common - UDP-glucose 6-dehydrogenase Sare_2174 199 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 159036331 Common - short-chain dehydrogenase/reductase SDR Sare_0671 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159037404 Common - protein of unknown function DUF28 Sare_1779 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 159038620 Common - Thioesterase Sare_3063 10 COG3319 COG3319, Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases Secondary metabolites biosynthesis, transport, and catabolism 159039300 Common - phage-related terminase Sare_3769 5 None None None 159038419 Nonpathogen - hypothetical protein Sare_2846 3 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 159039610 Common - cobalamin (vitamin B12) biosynthesis CbiX protein Sare_4082 9 COG2138 COG2138, Uncharacterized conserved protein Function unknown 159039891 Common - GCN5-related N-acetyltransferase Sare_4372 92 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 159040129 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_4633 36 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 159040523 Common - hypothetical protein Sare_5042 6 None None None 159040339 Common - transcriptional regulator, DeoR family Sare_4851 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 159037139 Nonpathogen - hypothetical protein Sare_1504 1 None None None 159037393 Common - two component transcriptional regulator, winged helix family Sare_1768 207 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159039916 Nonpathogen - hypothetical protein Sare_4401 1 None None None 159037397 Common - small GTP-binding protein Sare_1772 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 159039718 Nonpathogen - hypothetical protein Sare_4199 1 None None None 159040545 Common - replicative DNA helicase Sare_5064 220 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 159037949 Common - hypothetical protein Sare_2353 16 COG2887 COG2887, RecB family exonuclease DNA replication, recombination, and repair 159035894 Common - efflux transporter, RND family, MFP subunit Sare_0221 116 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 159036307 Common - hypothetical protein Sare_0647 5 None None None 159037206 Common - transcriptional regulator, GntR family Sare_1572 107 COG2188 PhnF, Transcriptional regulators Transcription 159038383 Common - Cholesterol oxidase Sare_2810 22 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 159036038 Common - beta-lactamase domain protein Sare_0371 121 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 159035861 Common - Vitamin K epoxide reductase Sare_0188 23 COG4243 COG4243, Predicted membrane protein Function unknown 159036591 Common - peptidase S8 and S53 subtilisin kexin sedolisin Sare_0938 110 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 159037456 Common - glycosyl transferase family 2 Sare_1832 85 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 159038558 Common - hypothetical protein Sare_2996 14 None None None 159035816 Common - Sterol-binding domain protein Sare_0143 8 COG3255 COG3255, Putative sterol carrier protein Lipid metabolism 159040318 Nonpathogen - hypothetical protein Sare_4830 1 None None None 159037658 Nonpathogen - hypothetical protein Sare_2053 5 None None None 159039786 Common - Extracellular ligand-binding receptor Sare_4267 58 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 159039060 Nonpathogen - NUDIX hydrolase Sare_3520 1 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 159038842 Common - ABC transporter related Sare_3301 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 159037068 Common - extracellular solute-binding protein family 1 Sare_1431 122 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 159038249 Common - Beta-ketoacyl synthase Sare_2674 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159037968 Common - diacylglycerol kinase catalytic region Sare_2372 109 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 159040301 Common - transcriptional regulator, TetR family Sare_4813 81 COG1309 AcrR, Transcriptional regulator Transcription 159040055 Common - Phosphoglycerate mutase Sare_4549 8 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 159037596 Common - hypothetical protein Sare_1973 3 None None None 159037843 Common - DoxX family protein Sare_2245 4 None None None 159038050 Common - hypothetical protein Sare_2467 12 None None None 159038922 Common - histidine triad (HIT) protein Sare_3382 12 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 159040211 Common - protein of unknown function DUF185 Sare_4720 46 COG1565 COG1565, Uncharacterized conserved protein Function unknown 159037525 Common - hemolysin A Sare_1902 130 COG1189 COG1189, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 159039307 Common - phage-related hypothetical protein Sare_3776 4 None None None 159040121 Common - hypothetical protein Sare_4625 20 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 159035735 Common - deoxycytidine triphosphate deaminase Sare_0061 159 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 159038467 Common - ribosomal protein L28 Sare_2903 157 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 159039404 Nonpathogen - hypothetical protein Sare_3874 1 None None None 159040388 Common - transcriptional regulator, XRE family Sare_4901 31 COG1396 HipB, Predicted transcriptional regulators Transcription 159036901 Common - Rieske (2Fe-2S) domain protein Sare_1258 84 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 159040086 Nonpathogen - hypothetical protein Sare_4582 1 None None None 159036619 Common - transcriptional regulator, MerR family Sare_0969 139 COG0789 SoxR, Predicted transcriptional regulators Transcription 159038706 Common - Integrase catalytic region Sare_3160 75 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 159035934 Common - nitroreductase Sare_0264 44 COG0778 NfnB, Nitroreductase Energy production and conversion 159036002 Common - two component transcriptional regulator, winged helix family Sare_0334 200 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159039899 Common - regulator of chromosome condensation RCC1 Sare_4380 38 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 159036725 Common - transcriptional regulator, LacI family Sare_1079 121 COG1609 PurR, Transcriptional regulators Transcription 159036803 Common - Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) Sare_1157 213 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 159038089 Common - peptide deformylase Sare_2508 207 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 159036118 Common - hypothetical protein Sare_0451 16 None None None 159039343 Common - Antibiotic biosynthesis monooxygenase Sare_3812 4 None None None 159039839 Common - ribosomal protein S12 Sare_4320 244 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 159036679 Nonpathogen - LPXTG-motif cell wall anchor domain Sare_1032 1 COG0435 ECM4, Predicted glutathione S-transferase Posttranslational modification, protein turnover, chaperones 159036198 Common - hypothetical protein Sare_0531 7 COG3883 COG3883, Uncharacterized protein conserved in bacteria Function unknown 159039428 Common - 4-oxalocrotonate decarboxylase Sare_3899 62 COG3971 COG3971, 2-keto-4-pentenoate hydratase Secondary metabolites biosynthesis, transport, and catabolism 159038579 Nonpathogen - A-factor biosynthesis repeat-containing protein Sare_3017 6 None None None 159040021 Common - DNA binding domain, excisionase family Sare_4511 13 COG2452 COG2452, Predicted site-specific integrase-resolvase DNA replication, recombination, and repair 159037413 Nonpathogen - hypothetical protein Sare_1789 1 None None None 159037994 Common - hypothetical protein Sare_2398 13 None None None 159040474 Nonpathogen - hypothetical protein Sare_4993 2 COG3889 COG3889, Predicted solute binding protein General function prediction only 159038969 Common - transcriptional regulator, TraR/DksA family Sare_3429 158 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 159040381 Common - amino acid adenylation domain Sare_4894 216 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159038829 Nonpathogen - hypothetical protein Sare_3288 1 None None None 159037680 Common - ABC transporter related Sare_2076 245 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 159038899 Common - SNARE associated Golgi protein Sare_3359 16 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 159038647 Common - hypothetical protein Sare_3097 13 None None None 159037811 Nonpathogen - transcriptional regulator, TetR family Sare_2212 1 COG3226 COG3226, Uncharacterized protein conserved in bacteria Function unknown 159040110 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Sare_4614 128 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 159035781 Common - Transketolase central region Sare_0108 216 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 159035762 Common - transcriptional regulator, AraC family Sare_0089 110 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 159037167 Common - Phosphoketolase Sare_1533 65 COG3957 COG3957, Phosphoketolase Carbohydrate transport and metabolism 159037185 Nonpathogen - hypothetical protein Sare_1551 1 None None None 159037796 Common - transcriptional regulator, winged helix family Sare_2197 31 COG3903 COG3903, Predicted ATPase General function prediction only 159035757 Common - rare lipoprotein A Sare_0084 136 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 159039067 Common - cytochrome c oxidase subunit III Sare_3527 159 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 159035886 Common - hypothetical protein Sare_0213 8 None None None 159036122 Nonpathogen - hypothetical protein Sare_0455 2 None None None 159036110 Common - TrkA-N domain protein Sare_0443 99 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 159037073 Common - Indigoidine synthase A family protein Sare_1436 49 COG2313 IndA, Uncharacterized enzyme involved in pigment biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 159039987 Common - protein of unknown function DUF178 Sare_4475 32 COG1427 COG1427, Predicted periplasmic solute-binding protein General function prediction only 159038721 Common - hypothetical protein Sare_3176 9 None None None 159038255 Common - 4'-phosphopantetheinyl transferase Sare_2680 24 COG2091 Sfp, Phosphopantetheinyl transferase Coenzyme metabolism 159036578 Common - protein of unknown function DUF179 Sare_0923 126 COG1678 COG1678, Putative transcriptional regulator Transcription 159036162 Common - putative methyltransferase Sare_0495 222 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159035966 Nonpathogen - hypothetical protein Sare_0297 5 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 159040462 Nonpathogen - hypothetical protein Sare_4978 1 None None None 159036281 Nonpathogen - hypothetical protein Sare_0616 1 None None None 159039797 Common - thiamine biosynthesis protein ThiS Sare_4278 44 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 159038036 Common - hypothetical protein Sare_2451 2 None None None 159038517 Common - hypothetical protein Sare_2953 17 None None None 159035694 Common - Sua5/YciO/YrdC/YwlC family protein Sare_0020 202 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 159037162 Common - two component transcriptional regulator, LuxR family Sare_1528 198 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159039175 Common - Saccharopine dehydrogenase (NAD(+), L-glutamate-forming) Sare_3639 44 COG3268 COG3268, Uncharacterized conserved protein Function unknown 159039371 Common - hypothetical protein Sare_3840 14 None None None 159038452 Common - hypothetical protein Sare_2888 5 COG3832 COG3832, Uncharacterized conserved protein Function unknown 159039341 Common - glycyl-tRNA synthetase Sare_3810 86 COG0423 GRS1, Glycyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 159039391 Common - ribonuclease, Rne/Rng family Sare_3861 186 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 159038119 Common - transcriptional regulator, TetR family Sare_2539 35 COG1309 AcrR, Transcriptional regulator Transcription 159039885 Common - acyl-CoA dehydrogenase domain protein Sare_4366 144 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159039551 Common - Sua5/YciO/YrdC/YwlC family protein Sare_4023 212 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 159039947 Common - peptidase M6 immune inhibitor A Sare_4435 17 COG4412 COG4412, Uncharacterized protein conserved in bacteria Function unknown 159037045 Common - small GTP-binding protein Sare_1407 225 COG2262 HflX, GTPases General function prediction only 159040134 Common - BioY protein Sare_4638 87 COG1268 BioY, Uncharacterized conserved protein General function prediction only 159038165 Nonpathogen - peptidase M50 Sare_2586 1 None None None 159038894 Common - X-Pro dipeptidyl-peptidase domain protein Sare_3354 59 COG2936 COG2936, Predicted acyl esterases General function prediction only 159038308 Common - protein of unknown function DUF1486 Sare_2735 9 COG5485 COG5485, Predicted ester cyclase General function prediction only 159036364 Common - Alkaline phosphatase Sare_0707 57 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 159039971 Common - NADH-quinone oxidoreductase, E subunit Sare_4459 156 COG1905 NuoE, NADH:ubiquinone oxidoreductase 24 kD subunit Energy production and conversion 159038838 Common - short-chain dehydrogenase/reductase SDR Sare_3297 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159035675 Common - chromosomal replication initiator protein DnaA Sare_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 159036169 Common - hypothetical protein Sare_0502 18 None None None 159038240 Common - AMP-dependent synthetase and ligase Sare_2665 212 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159038211 Common - transcriptional regulator, GntR family Sare_2634 119 COG2188 PhnF, Transcriptional regulators Transcription 159040204 Common - putative transcriptional acitvator, Baf family Sare_4713 131 COG1521 COG1521, Putative transcriptional regulator, homolog of Bvg accessory factor Transcription 159036617 Common - Cyclopropane-fatty-acyl-phospholipid synthase Sare_0967 131 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 159039976 Common - geranylgeranyl reductase Sare_4464 87 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 159037594 Common - CRISPR-associated helicase Cas3 Sare_1971 53 COG1203 COG1203, Predicted helicases General function prediction only 159039364 Common - histidine triad (HIT) protein Sare_3833 217 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 159036633 Common - major facilitator superfamily MFS_1 Sare_0984 15 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159039833 Common - ribosomal protein L4/L1e Sare_4314 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 159035795 Common - hypothetical protein Sare_0122 7 None None None 159038797 Common - membrane-flanked domain Sare_3256 22 COG3402 COG3402, Uncharacterized conserved protein Function unknown 159039329 Common - ABC-2 type transporter Sare_3798 69 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 159039821 Common - ribosomal protein S14 Sare_4302 210 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 159038344 Nonpathogen - hypothetical protein Sare_2771 1 None None None 159038970 Common - protein of unknown function DUF167 Sare_3430 17 COG1872 COG1872, Uncharacterized conserved protein Function unknown 159037096 Common - histidine kinase Sare_1459 212 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159040214 Common - Substrate-binding region of ABC-type glycine betaine transport system Sare_4723 44 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 159039750 Common - chaperonin GroEL Sare_4231 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 159036438 Common - AIG2 family protein Sare_0781 28 COG2105 COG2105, Uncharacterized conserved protein Function unknown 159039348 Common - transcriptional regulator, ArsR family Sare_3817 18 COG0640 ArsR, Predicted transcriptional regulators Transcription 159036432 Common - serine/threonine protein kinase Sare_0775 149 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 159040081 Common - UspA domain protein Sare_4576 20 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 159037546 Nonpathogen - hypothetical protein Sare_1923 1 None None None 159039322 Common - prophage antirepressor Sare_3791 38 COG3617 COG3617, Prophage antirepressor Transcription 159036401 Nonpathogen - hypothetical protein Sare_0744 1 None None None 159039842 Nonpathogen - glyoxalase/bleomycin resistance protein/dioxygenase Sare_4323 1 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 159039479 Nonpathogen - hypothetical protein Sare_3951 1 None None None 159036954 Common - sodium:dicarboxylate symporter Sare_1315 159 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 159037023 Nonpathogen - hypothetical protein Sare_1385 1 None None None 159040193 Nonpathogen - hypothetical protein Sare_4702 1 None None None 159039736 Nonpathogen - hypothetical protein Sare_4217 1 None None None 159040383 Common - MbtH domain protein Sare_4896 30 COG3251 COG3251, Uncharacterized protein conserved in bacteria Function unknown 159037437 Common - transcriptional regulator, ArsR family Sare_1813 7 COG0640 ArsR, Predicted transcriptional regulators Transcription 159039013 Common - protein of unknown function DUF422 Sare_3473 28 COG2324 COG2324, Predicted membrane protein Function unknown 159037325 Common - NAD(+) kinase Sare_1700 231 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 159040159 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Sare_4668 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 159037954 Common - AAA ATPase central domain protein Sare_2358 249 COG1222 RPT1, ATP-dependent 26S proteasome regulatory subunit Posttranslational modification, protein turnover, chaperones 159037746 Nonpathogen - hypothetical protein Sare_2143 1 None None None 159036651 Common - MOSC domain containing protein Sare_1002 47 COG3217 COG3217, Uncharacterized Fe-S protein General function prediction only 159039766 Common - alanine racemase Sare_4247 200 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 159036264 Nonpathogen - hypothetical protein Sare_0598 2 None None None 159037914 Common - putative undecaprenol kinase Sare_2318 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 159037193 Common - short-chain dehydrogenase/reductase SDR Sare_1559 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159037662 Nonpathogen - hypothetical protein Sare_2057 2 None None None 159039049 Common - AMP-dependent synthetase and ligase Sare_3509 216 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 159038376 Common - Enoyl-CoA hydratase/isomerase Sare_2803 84 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 159039743 Common - FAD dependent oxidoreductase Sare_4224 34 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 159038604 Common - transcriptional regulator, PadR-like family Sare_3047 14 COG1695 COG1695, Predicted transcriptional regulators Transcription 159039572 Common - hypothetical protein Sare_4044 2 None None None 159040294 Common - NUDIX hydrolase Sare_4804 70 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 159038662 Common - luciferase family protein Sare_3116 8 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 159038954 Common - Alcohol dehydrogenase zinc-binding domain protein Sare_3414 137 COG2130 COG2130, Putative NADP-dependent oxidoreductases General function prediction only 159038661 Common - short-chain dehydrogenase/reductase SDR Sare_3115 205 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 159040409 Nonpathogen - hypothetical protein Sare_4924 1 None None None 159038253 Nonpathogen - hypothetical protein Sare_2678 1 None None None 159039350 Common - acyl-CoA dehydrogenase domain protein Sare_3819 163 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159038289 Common - major facilitator superfamily MFS_1 Sare_2714 23 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 159039498 Common - transcriptional regulator, LacI family Sare_3970 125 COG1609 PurR, Transcriptional regulators Transcription 159038580 Common - hypothetical protein Sare_3018 17 COG4529 COG4529, Uncharacterized protein conserved in bacteria Function unknown 159039455 Common - peptidase M20 Sare_3926 191 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 159039871 Common - DNA polymerase LigD ligase region Sare_4352 107 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 159036073 Common - Ppx/GppA phosphatase Sare_0406 178 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 159037191 Nonpathogen - hypothetical protein Sare_1557 1 None None None 159035820 Common - short-chain dehydrogenase/reductase SDR Sare_0147 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159040378 Common - amino acid adenylation domain Sare_4891 192 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159037201 Nonpathogen - hypothetical protein Sare_1567 1 COG4982 COG4982, 3-oxoacyl- acyl-carrier protein 159037824 Common - protein of unknown function DUF156 Sare_2226 44 COG1937 COG1937, Uncharacterized protein conserved in bacteria Function unknown 159037985 Common - glycosyl transferase family 2 Sare_2389 192 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 159039079 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase Sare_3539 208 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 159036063 Common - hypothetical protein Sare_0396 14 None None None 159038777 Common - tRNA/rRNA methyltransferase (SpoU) Sare_3233 114 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 159037344 Common - peptidase C60 sortase A and B Sare_1719 18 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 159036608 Common - hypothetical protein Sare_0958 18 COG5515 COG5515, Uncharacterized conserved small protein Function unknown 159035880 Common - coagulation factor 5/8 type domain protein Sare_0207 9 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 159038854 Common - hypothetical protein Sare_3313 19 None None None 159038096 Common - glycine dehydrogenase Sare_2515 172 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 159038206 Common - binding-protein-dependent transport systems inner membrane component Sare_2629 139 COG0555 CysU, ABC-type sulfate transport system, permease component Posttranslational modification, protein turnover, chaperones 159036571 Common - transcriptional regulator, PadR-like family Sare_0916 18 COG1695 COG1695, Predicted transcriptional regulators Transcription 159036443 Common - ABC transporter related Sare_0786 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 159036527 Common - protein of unknown function DUF255 Sare_0871 105 COG1331 COG1331, Highly conserved protein containing a thioredoxin domain Posttranslational modification, protein turnover, chaperones 159039106 Common - hypothetical protein Sare_3566 19 None None None 159039357 Common - DNA repair protein RecO Sare_3826 43 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 159040057 Common - ABC-2 type transporter Sare_4551 80 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 159040581 Common - putative transcriptional regulator, GntR family Sare_5101 211 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 159039855 Common - hypothetical protein Sare_4336 7 None None None 159037943 Common - transcriptional regulator, AraC family Sare_2347 110 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 159040092 Common - NmrA family protein Sare_4590 126 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 159036611 Common - transcriptional regulator, TetR family Sare_0961 9 COG1309 AcrR, Transcriptional regulator Transcription 159036078 Common - ABC transporter related Sare_0411 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 159036369 Nonpathogen - NADH-ubiquinone oxidoreductase chain 4L Sare_0712 3 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 159038636 Common - UvrD/Rep helicase Sare_3085 83 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 159039217 Nonpathogen - PilT protein domain protein Sare_3686 1 COG5573 COG5573, Predicted nucleic-acid-binding protein, contains PIN domain General function prediction only 159039257 Nonpathogen - hypothetical protein Sare_3726 1 None None None 159039963 Common - proton-translocating NADH-quinone oxidoreductase, chain M Sare_4451 207 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 159037938 Common - amino acid permease-associated region Sare_2342 124 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 159039582 Nonpathogen - hypothetical protein Sare_4054 1 None None None 159036666 Common - Exonuclease RNase T and DNA polymerase III Sare_1017 88 COG1949 Orn, Oligoribonuclease (3'->5' exoribonuclease) RNA processing and modification 159036049 Common - alpha/beta hydrolase fold Sare_0382 32 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159036011 Nonpathogen - hypothetical protein Sare_0343 1 COG3599 DivIVA, Cell division initiation protein Cell division and chromosome partitioning 159036982 Common - hypothetical protein Sare_1343 12 COG5650 COG5650, Predicted integral membrane protein Function unknown 159039887 Common - Serine-type D-Ala-D-Ala carboxypeptidase Sare_4368 128 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 159036136 Nonpathogen - NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Sare_0469 2 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 159038152 Common - CRISPR-associated helicase Cas3 Sare_2572 46 COG1203 COG1203, Predicted helicases General function prediction only 159036354 Common - metal dependent phosphohydrolase Sare_0696 30 COG1896 COG1896, Predicted hydrolases of HD superfamily General function prediction only 159036953 Common - protein of unknown function DUF664 Sare_1314 13 None None None 159038018 Common - Helix-turn-helix type 11 domain protein Sare_2425 76 COG2378 COG2378, Predicted transcriptional regulator Transcription 159039333 Common - DNA primase Sare_3802 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 159038900 Common - GTP-binding protein TypA Sare_3360 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 159039630 Nonpathogen - hypothetical protein Sare_4102 3 None None None 159036601 Nonpathogen - hypothetical protein Sare_0949 1 None None None 159038871 Common - RimK domain protein ATP-grasp Sare_3330 20 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 159037155 Common - cytochrome P450 Sare_1521 71 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159039020 Common - serine/threonine protein kinase with PASTA sensor(s) Sare_3480 155 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 159037032 Common - extracellular solute-binding protein family 3 Sare_1394 164 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 159036158 Common - multi antimicrobial extrusion protein MatE Sare_0491 19 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 159038807 Common - peptidase S8 and S53 subtilisin kexin sedolisin Sare_3266 62 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 159039162 Common - glycoside hydrolase family 3 domain protein Sare_3626 184 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 159038177 Common - PilT protein domain protein Sare_2598 38 COG3744 COG3744, Uncharacterized protein conserved in bacteria Function unknown 159039474 Common - aspartate-semialdehyde dehydrogenase Sare_3946 237 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 159037858 Nonpathogen - hypothetical protein Sare_2261 1 None None None 159036912 Common - Oleoyl-(acyl-carrier-protein) hydrolase Sare_1269 56 COG3208 GrsT, Predicted thioesterase involved in non-ribosomal peptide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 159040137 Common - hypothetical protein Sare_4642 11 None None None 159039904 Common - proline iminopeptidase Sare_4387 88 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159036007 Common - hypothetical protein Sare_0339 4 None None None 159040269 Common - extracellular solute-binding protein family 5 Sare_4778 138 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 159035887 Common - cholesterol esterase Sare_0214 7 None None None 159039072 Common - Cytochrome c oxidase subunit II Sare_3532 140 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 159038397 Nonpathogen - hypothetical protein Sare_2824 1 None None None 159038616 Common - AMP-dependent synthetase and ligase Sare_3059 219 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159038082 Common - hypothetical protein Sare_2501 7 None None None 159040303 Common - hypothetical protein Sare_4815 9 None None None 159036879 Common - radical SAM enzyme, Cfr family Sare_1235 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 159039223 Common - integrase family protein Sare_3692 194 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 159039991 Nonpathogen - hypothetical protein Sare_4479 1 None None None 159035741 Common - Methylenetetrahydrofolate dehydrogenase (NADP(+)) Sare_0067 224 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 159040554 Common - hypothetical protein Sare_5073 11 None None None 159035769 Common - LamB/YcsF family protein Sare_0096 100 COG1540 COG1540, Uncharacterized proteins, homologs of lactam utilization protein B General function prediction only 159036105 Nonpathogen - hypothetical protein Sare_0438 1 None None None 159037484 Common - peptide deformylase Sare_1861 210 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 159040043 Common - major facilitator superfamily MFS_1 Sare_4533 145 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 159040446 Common - cob(II)yrinic acid a,c-diamide reductase Sare_4962 93 COG0778 NfnB, Nitroreductase Energy production and conversion 159037989 Common - GCN5-related N-acetyltransferase Sare_2393 17 COG0456 RimI, Acetyltransferases General function prediction only 159039879 Common - rfaE bifunctional protein Sare_4360 148 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 159036260 Common - hypothetical protein Sare_0594 19 COG5293 COG5293, Uncharacterized protein conserved in bacteria Function unknown 159036656 Common - hypothetical protein Sare_1007 4 None None None 159040282 Nonpathogen - hypothetical protein Sare_4791 1 None None None 159036360 Common - inner-membrane translocator Sare_0703 102 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 159037645 Common - hypothetical protein Sare_2037 12 None None None 159039264 Nonpathogen - hypothetical protein Sare_3733 1 None None None 159035702 Common - Rhodanese domain protein Sare_0028 144 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 159038470 Common - short-chain dehydrogenase/reductase SDR Sare_2906 234 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 159035841 Common - Glu/Leu/Phe/Val dehydrogenase dimerisation region Sare_0168 97 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 159036977 Common - ribosomal protein S15 Sare_1338 214 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 159037980 Common - D-Lysine 56-aminomutase alpha subunit Sare_2384 17 None None None 159038746 Common - membrane-bound metal-dependent hydrolase Sare_3201 11 None None None 159036872 Common - protein of unknown function UPF0102 Sare_1228 119 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 159036520 Common - Amidase Sare_0864 218 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 159038964 Nonpathogen - hypothetical protein Sare_3424 1 None None None 159036987 Common - beta-lactamase domain protein Sare_1348 155 COG0595 COG0595, Predicted hydrolase of the metallo-beta-lactamase superfamily General function prediction only 159038026 Common - transcriptional regulator, HxlR family Sare_2439 143 COG1733 COG1733, Predicted transcriptional regulators Transcription 159040341 Nonpathogen - hypothetical protein Sare_4853 1 None None None 159038357 Common - aminotransferase class I and II Sare_2784 218 COG1168 MalY, Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities Amino acid transport and metabolism 159039274 Common - integrase family protein Sare_3743 185 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 159037853 Common - glutamate--cysteine ligase GCS2 Sare_2256 53 COG3572 GshA, Gamma-glutamylcysteine synthetase Coenzyme metabolism 159037306 Common - ABC transporter related Sare_1680 247 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 159040170 Common - transcriptional regulator, AsnC family Sare_4679 143 COG1522 Lrp, Transcriptional regulators Transcription 159037320 Common - TRAP transporter solute receptor, TAXI family Sare_1695 89 COG2358 Imp, TRAP-type uncharacterized transport system, periplasmic component General function prediction only 159037669 Common - major facilitator superfamily MFS_1 Sare_2064 88 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159038988 Common - domain of unknown function DUF1727 Sare_3448 49 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 159039318 Nonpathogen - hypothetical protein Sare_3787 1 None None None 159036943 Common - 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase Sare_1304 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 159037898 Common - Cupin 4 family protein Sare_2302 46 COG2850 COG2850, Uncharacterized conserved protein Function unknown 159039945 Common - hypothetical protein Sare_4433 9 None None None 159037006 Common - Aminopeptidase Y Sare_1367 58 COG2234 Iap, Predicted aminopeptidases General function prediction only 159038044 Common - protein of unknown function DUF218 Sare_2461 16 COG1434 COG1434, Uncharacterized conserved protein Function unknown 159035729 Nonpathogen - hypothetical protein Sare_0055 1 None None None 159036267 Nonpathogen - hypothetical protein Sare_0601 1 None None None 159036032 Common - major facilitator superfamily MFS_1 Sare_0365 30 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159035863 Common - nitrate/nitrite transporter-like protein Sare_0190 79 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 159039691 Common - methylated-DNA--protein-cysteine methyltransferase Sare_4164 89 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 159036854 Common - integrase family protein Sare_1208 209 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 159038160 Common - Integrase catalytic region Sare_2580 74 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 159038693 Common - Ricin B lectin Sare_3147 21 None None None 159037263 Common - hypothetical protein Sare_1633 9 COG3544 COG3544, Uncharacterized protein conserved in bacteria Function unknown 159036890 Common - Beta-ketoacyl synthase Sare_1247 210 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159036321 Common - protein tyrosine/serine phosphatase Sare_0661 11 COG2365 COG2365, Protein tyrosine/serine phosphatase Signal transduction mechanisms 159036673 Common - IstB domain protein ATP-binding protein Sare_1025 98 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 159036916 Common - Transketolase central region Sare_1273 194 COG3958 COG3958, Transketolase, C-terminal subunit Carbohydrate transport and metabolism 159039480 Nonpathogen - hypothetical protein Sare_3952 1 None None None 159035947 Common - Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase Sare_0278 208 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 159036776 Common - branched-chain amino acid aminotransferase Sare_1130 209 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 159036491 Common - protein of unknown function DUF501 Sare_0835 27 COG1507 COG1507, Uncharacterized conserved protein Function unknown 159039770 Common - aminotransferase class I and II Sare_4251 234 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 159036868 Nonpathogen - hypothetical protein Sare_1223 1 None None None 159038486 Common - Alcohol dehydrogenase zinc-binding domain protein Sare_2922 135 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 159040004 Common - oxidoreductase, short chain dehydrogenase/reductase family Sare_4494 149 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159036693 Common - L-lysine 6-monooxygenase (NADPH) Sare_1046 52 COG3486 IucD, Lysine/ornithine N-monooxygenase Secondary metabolites biosynthesis, transport, and catabolism 159037287 Common - extracellular solute-binding protein family 5 Sare_1661 214 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 159038108 Common - hypothetical protein Sare_2527 5 None None None 159038405 Common - hypothetical protein Sare_2832 16 None None None 159038888 Nonpathogen - hypothetical protein Sare_3348 2 None None None 159037754 Common - lysine/ornithine N-monooxygenase Sare_2151 52 COG3486 IucD, Lysine/ornithine N-monooxygenase Secondary metabolites biosynthesis, transport, and catabolism 159035943 Common - Antibiotic biosynthesis monooxygenase Sare_0274 14 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 159038313 Common - Pyridoxal-dependent decarboxylase Sare_2740 124 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 159040289 Common - metallophosphoesterase Sare_4798 81 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 159036027 Nonpathogen - Lantibiotic dehydratase domain protein Sare_0360 4 None None None 159039869 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_4350 14 None None None 159036859 Nonpathogen - hypothetical protein Sare_1214 1 None None None 159037707 Common - abortive infection protein Sare_2104 6 None None None 159040169 Nonpathogen - transcriptional regulator, ArsR family Sare_4678 3 COG0640 ArsR, Predicted transcriptional regulators Transcription 159036750 Common - Electron transfer flavoprotein alpha subunit Sare_1104 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 159040161 Common - Endoribonuclease L-PSP Sare_4670 86 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 159037929 Common - monooxygenase FAD-binding Sare_2333 102 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 159039491 Common - hypothetical protein Sare_3963 4 None None None 159035805 Common - SNARE associated Golgi protein Sare_0132 175 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 159037567 Nonpathogen - hypothetical protein Sare_1944 1 None None None 159036142 Nonpathogen - protein of unknown function DUF1275 Sare_0475 2 COG3619 COG3619, Predicted membrane protein Function unknown 159036179 Common - pyridoxamine 5'-phosphate oxidase Sare_0512 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 159036439 Common - pyridine nucleotide-disulphide oxidoreductase dimerisation region Sare_0782 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 159037931 Common - glucose-1-phosphate thymidylyltransferase Sare_2335 234 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 159038521 Common - glutamate dehydrogenase (NAD(P)+) Sare_2957 74 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 159037978 Common - hypothetical protein Sare_2382 15 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 159038436 Common - peptidase C14 caspase catalytic subunit p20 Sare_2871 89 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 159040468 Common - glycosyl transferase family 2 Sare_4987 227 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 159039385 Common - nicotinate (nicotinamide) nucleotide adenylyltransferase Sare_3854 184 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 159039868 Common - hypothetical protein Sare_4349 14 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 159040546 Common - ribosomal protein L9 Sare_5065 215 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 159038331 Common - transcriptional regulator, TetR family Sare_2758 8 COG1309 AcrR, Transcriptional regulator Transcription 159038788 Common - hypothetical protein Sare_3246 15 None None None 159038509 Common - DegT/DnrJ/EryC1/StrS aminotransferase Sare_2945 192 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 159039779 Common - nitrite reductase (NAD(P)H), large subunit Sare_4260 190 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 159039599 Common - hypothetical protein Sare_4071 8 None None None 159036934 Common - protein of unknown function DUF1214 Sare_1293 39 COG5361 COG5361, Uncharacterized conserved protein Function unknown 159039112 Nonpathogen - hypothetical protein Sare_3574 1 None None None 159039684 Common - transcriptional regulator, XRE family Sare_4156 7 COG1476 COG1476, Predicted transcriptional regulators Transcription 159036055 Common - NmrA family protein Sare_0388 41 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 159036463 Common - GtrA family protein Sare_0806 19 COG2246 COG2246, Predicted membrane protein Function unknown 159039247 Common - portal protein Sare_3716 37 COG4695 COG4695, Phage-related protein Function unknown 159039535 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase Sare_4007 215 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 159035784 Common - hypothetical protein Sare_0111 3 None None None 159037603 Nonpathogen - hypothetical protein Sare_1981 1 None None None 159037578 Nonpathogen - NUDIX hydrolase Sare_1955 3 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 159038535 Nonpathogen - hypothetical protein Sare_2972 1 None None None 159036039 Common - peroxiredoxins-like protein Sare_0372 5 COG2044 COG2044, Predicted peroxiredoxins General function prediction only 159038121 Nonpathogen - hypothetical protein Sare_2541 1 None None None 159037251 Common - binding-protein-dependent transport systems inner membrane component Sare_1621 132 COG1174 OpuBB, ABC-type proline/glycine betaine transport systems, permease component Amino acid transport and metabolism 159038120 Nonpathogen - hypothetical protein Sare_2540 3 COG3427 COG3427, Uncharacterized conserved protein Function unknown 159037171 Common - transcriptional regulator, PadR-like family Sare_1537 7 COG1695 COG1695, Predicted transcriptional regulators Transcription 159037495 Common - phosphoribosyl-ATP pyrophosphohydrolase Sare_1872 31 COG0140 HisI, Phosphoribosyl-ATP pyrophosphohydrolase Amino acid transport and metabolism 159038439 Common - hypothetical protein Sare_2874 21 COG3541 COG3541, Predicted nucleotidyltransferase General function prediction only 159036704 Common - peptidase C45 acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Sare_1057 11 COG4927 COG4927, Predicted choloylglycine hydrolase General function prediction only 159038360 Common - protein of unknown function DUF461 Sare_2787 73 COG2847 COG2847, Uncharacterized protein conserved in bacteria Function unknown 159039126 Nonpathogen - hypothetical protein Sare_3588 1 None None None 159036708 Common - UbiD family decarboxylase Sare_1061 153 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 159037763 Common - catalase/peroxidase HPI Sare_2160 98 COG0376 KatG, Catalase (peroxidase I) Inorganic ion transport and metabolism 159039698 Common - hypothetical protein Sare_4171 15 None None None 159039055 Common - Ste24 endopeptidase Sare_3515 62 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 159036904 Common - protein of unknown function DUF1271 Sare_1261 8 COG1141 Fer, Ferredoxin Energy production and conversion 159036255 Common - Haloacid dehalogenase domain protein hydrolase Sare_0589 27 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 159040099 Common - hypothetical protein Sare_4603 7 COG4538 COG4538, Uncharacterized conserved protein Function unknown 159036316 Common - hypothetical protein Sare_0656 16 None None None 159038865 Common - Phosphoglycerate kinase Sare_3324 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 159037443 Common - alanyl-tRNA synthetase Sare_1819 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159037526 Common - NAD(+) kinase Sare_1903 238 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 159036374 Nonpathogen - hypothetical protein Sare_0717 2 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 159037465 Common - translation elongation factor P Sare_1842 219 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 159036411 Common - inner-membrane translocator Sare_0754 108 COG1079 COG1079, Uncharacterized ABC-type transport system, permease component General function prediction only 159035770 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Sare_0097 63 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 159040039 Common - GntR domain protein Sare_4529 113 COG2186 FadR, Transcriptional regulators Transcription 159036151 Common - 3-Oxoacyl-(acyl-carrier-protein (ACP)) synthase III domain protein Sare_0484 22 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 159035825 Common - transcriptional regulator, GntR family Sare_0152 71 COG2188 PhnF, Transcriptional regulators Transcription 159039291 Nonpathogen - hypothetical protein Sare_3760 1 None None None 159035868 Common - respiratory nitrate reductase, gamma subunit Sare_0195 58 COG2181 NarI, Nitrate reductase gamma subunit Energy production and conversion 159038582 Nonpathogen - hypothetical protein Sare_3020 1 None None None 159040258 Common - carboxyl transferase Sare_4767 151 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 159037279 Common - transposase mutator type Sare_1651 83 COG3328 COG3328, Transposase and inactivated derivatives DNA replication, recombination, and repair 159039791 Common - hypothetical protein Sare_4272 6 COG5553 COG5553, Predicted metal-dependent enzyme of the double-stranded beta helix superfamily General function prediction only 159036748 Nonpathogen - hypothetical protein Sare_1102 1 None None None 159036738 Common - ROK family protein Sare_1092 135 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 159036809 Nonpathogen - hypothetical protein Sare_1163 1 None None None 159038277 Common - precorrin-3B C17-methyltransferase Sare_2702 118 COG1010 CobJ, Precorrin-3B methylase Coenzyme metabolism 159038496 Common - Methyltransferase type 12 Sare_2932 39 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 159040088 Common - Pyridoxal-5'-phosphate-dependent protein beta subunit Sare_4585 217 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 159039656 Common - peptidase M16 domain protein Sare_4128 193 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 159037625 Nonpathogen - hypothetical protein Sare_2011 1 None None None 159039330 Common - ABC-2 type transporter Sare_3799 41 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 159037868 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Sare_2271 221 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 159036484 Common - Phosphoenolpyruvate carboxylase Sare_0828 116 COG2352 Ppc, Phosphoenolpyruvate carboxylase Energy production and conversion 159036379 Common - methionyl-tRNA synthetase Sare_0722 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159037861 Common - hypothetical protein Sare_2264 5 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 159037130 Common - hypothetical protein Sare_1494 17 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 159039042 Common - hypothetical protein Sare_3502 11 COG2267 PldB, Lysophospholipase Lipid metabolism 159038242 Common - lipolytic protein G-D-S-L family Sare_2667 18 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 159039136 Common - Bifunctional DNA primase/polymerase Sare_3600 4 None None None 159038183 Common - NAD-dependent epimerase/dehydratase Sare_2604 154 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 159040364 Common - Ribonucleoside-diphosphate reductase Sare_4876 157 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 159039660 Common - hypothetical protein Sare_4132 121 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 159036172 Common - transcriptional regulator, MarR family Sare_0505 88 COG1846 MarR, Transcriptional regulators Transcription 159037877 Common - glycosyl transferase family 2 Sare_2280 113 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 159039525 Common - protein of unknown function UPF0118 Sare_3997 42 COG0628 PerM, Predicted permease General function prediction only 159039195 Nonpathogen - hypothetical protein Sare_3660 1 None None None 159039604 Nonpathogen - putative phage repressor Sare_4076 4 COG2932 COG2932, Predicted transcriptional regulator Transcription 159035976 Common - protein of unknown function DUF574 Sare_0308 12 None None None 159036832 Common - aminoglycoside phosphotransferase Sare_1186 12 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 159040328 Nonpathogen - hypothetical protein Sare_4840 3 COG5373 COG5373, Predicted membrane protein Function unknown 159036053 Common - Endoribonuclease L-PSP Sare_0386 8 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 159036661 Nonpathogen - hypothetical protein Sare_1012 1 None None None 159037971 Common - 5'-3' exonuclease Sare_2375 216 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 159036553 Common - Phosphomannomutase Sare_0898 240 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 159039027 Common - binding-protein-dependent transport systems inner membrane component Sare_3487 147 COG4176 ProW, ABC-type proline/glycine betaine transport system, permease component Amino acid transport and metabolism 159038654 Common - transposase IS4 family protein Sare_3106 20 None None None 159035994 Common - phosphate transporter Sare_0326 170 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 159038442 Common - alpha/beta hydrolase fold Sare_2878 134 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159038133 Common - binding-protein-dependent transport systems inner membrane component Sare_2553 131 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 159040001 Nonpathogen - Cupin 2 conserved barrel domain protein Sare_4491 1 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 159035765 Nonpathogen - hypothetical protein Sare_0092 2 None None None 159040400 Nonpathogen - hypothetical protein Sare_4914 1 None None None 159039513 Common - peptidase C60 sortase A and B Sare_3985 16 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 159037580 Nonpathogen - dTMP kinase Sare_1957 2 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 159038371 Common - luciferase family protein Sare_2798 42 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 159038935 Common - tryptophan synthase, alpha subunit Sare_3395 214 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 159037014 Nonpathogen - hypothetical protein Sare_1376 1 None None None 159039726 Common - ATP-dependent DNA helicase PcrA Sare_4207 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 159037236 Common - polymorphic outer membrane protein Sare_1605 4 None None None 159040431 Common - putative hydrolase Sare_4947 38 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159039140 Nonpathogen - hypothetical protein Sare_3604 1 None None None 159040355 Nonpathogen - hypothetical protein Sare_4867 1 None None None 159040451 Nonpathogen - hypothetical protein Sare_4967 1 None None None 159040106 Common - glycerol kinase Sare_4610 177 COG0554 GlpK, Glycerol kinase Energy production and conversion 159039281 Nonpathogen - hypothetical protein Sare_3750 1 None None None 159036218 Common - Erythronolide synthase Sare_0551 210 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159036518 Common - histidine triad (HIT) protein Sare_0862 168 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 159037974 Common - transcriptional regulator, AsnC family Sare_2378 150 COG1522 Lrp, Transcriptional regulators Transcription 159036878 Common - Phosphatidate cytidylyltransferase Sare_1234 215 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 159040539 Common - molybdenum cofactor synthesis domain Sare_5058 114 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 159037514 Common - UspA domain protein Sare_1891 42 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 159038191 Common - transcriptional regulator, XRE family Sare_2613 100 COG1396 HipB, Predicted transcriptional regulators Transcription 159040530 Common - UvrD/REP helicase Sare_5049 233 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 159038962 Common - Histidinol dehydrogenase Sare_3422 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 159036165 Nonpathogen - hypothetical protein Sare_0498 1 None None None 159035775 Common - short-chain dehydrogenase/reductase SDR Sare_0102 211 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159039510 Nonpathogen - hypothetical protein Sare_3982 2 None None None 159040478 Nonpathogen - hypothetical protein Sare_4997 1 None None None 159037223 Common - hypothetical protein Sare_1592 8 None None None 159037950 Common - peptidase M50 Sare_2354 9 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 159040557 Nonpathogen - hypothetical protein Sare_5076 1 None None None 159038925 Common - pyruvate kinase Sare_3385 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 159039897 Common - Epoxide hydrolase domain protein Sare_4378 67 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159039563 Common - arginyl-tRNA synthetase Sare_4035 247 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159037804 Common - short-chain dehydrogenase/reductase SDR Sare_2205 186 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 159038222 Common - pyridoxal kinase Sare_2647 69 COG2240 PdxK, Pyridoxal/pyridoxine/pyridoxamine kinase Coenzyme metabolism 159037540 Common - chromosome segregation and condensation protein ScpA Sare_1917 85 COG1354 COG1354, Uncharacterized conserved protein Function unknown 159037425 Common - preprotein translocase, YajC subunit Sare_1801 188 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 159038040 Nonpathogen - hypothetical protein Sare_2456 1 COG1846 MarR, Transcriptional regulators Transcription 159037717 Common - Alcohol dehydrogenase zinc-binding domain protein Sare_2114 178 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 159035929 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Sare_0259 249 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 159038005 Common - glycoside hydrolase family 5 Sare_2410 24 COG2730 BglC, Endoglucanase Carbohydrate transport and metabolism 159037831 Common - SNARE associated Golgi protein Sare_2233 136 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 159037208 Nonpathogen - hypothetical protein Sare_1574 1 None None None 159037351 Common - protein serine/threonine phosphatase Sare_1726 126 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 159038763 Common - transcriptional regulator, MerR family Sare_3218 123 COG0789 SoxR, Predicted transcriptional regulators Transcription 159036811 Common - thiamine-monophosphate kinase Sare_1165 157 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 159035906 Common - protein of unknown function DUF307 Sare_0233 41 COG3304 COG3304, Predicted membrane protein Function unknown 159038073 Common - integrase family protein Sare_2492 160 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 159038328 Common - glycosyl transferase family 2 Sare_2755 57 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 159036886 Common - oxidoreductase domain protein Sare_1243 27 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 159037691 Common - hypothetical protein Sare_2088 4 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 159037071 Common - hypothetical protein Sare_1434 10 None None None 159036547 Common - aminotransferase class-III Sare_0892 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 159038123 Common - hypothetical protein Sare_2543 14 COG1571 COG1571, Predicted DNA-binding protein containing a Zn-ribbon domain General function prediction only 159036944 Common - transcriptional regulator, XRE family Sare_1305 41 COG1396 HipB, Predicted transcriptional regulators Transcription 159039272 Nonpathogen - hypothetical protein Sare_3741 2 None None None 159039671 Nonpathogen - hypothetical protein Sare_4143 1 None None None 159036713 Common - short-chain dehydrogenase/reductase SDR Sare_1066 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159039931 Nonpathogen - hypothetical protein Sare_4416 1 None None None 159039157 Common - 3-oxoacyl-(acyl-carrier-protein) synthase III Sare_3621 202 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 159037756 Common - FkbH like protein Sare_2153 28 COG3882 FkbH, Predicted enzyme involved in methoxymalonyl-ACP biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 159037539 Common - Cobyrinic acid ac-diamide synthase Sare_1916 230 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 159038391 Common - acyl-CoA dehydrogenase domain protein Sare_2818 125 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159039007 Common - UMUC domain protein DNA-repair protein Sare_3467 15 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 159039531 Common - methylmalonyl-CoA mutase, large subunit Sare_4003 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 159037298 Common - alpha/beta hydrolase fold Sare_1672 14 COG4757 COG4757, Predicted alpha/beta hydrolase General function prediction only 159036781 Common - ATPase associated with various cellular activities AAA_3 Sare_1135 176 COG0714 COG0714, MoxR-like ATPases General function prediction only 159039930 Nonpathogen - hypothetical protein Sare_4415 9 COG4894 COG4894, Uncharacterized conserved protein Function unknown 159037266 Common - Heat shock protein 70 Sare_1636 234 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 159039973 Common - NADH (or F420H2) dehydrogenase, subunit C Sare_4461 179 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 159038499 Nonpathogen - hypothetical protein Sare_2935 1 None None None 159036104 Nonpathogen - hypothetical protein Sare_0437 5 None None None 159036366 Nonpathogen - hypothetical protein Sare_0709 3 None None None 159036196 Common - hypothetical protein Sare_0529 4 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 159038504 Common - daunorubicin resistance ABC transporter ATPase subunit Sare_2940 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159038149 Nonpathogen - hypothetical protein Sare_2569 1 None None None 159037500 Common - ribosomal protein L20 Sare_1877 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 159040264 Common - regulatory protein GntR HTH Sare_4773 98 COG2186 FadR, Transcriptional regulators Transcription 159037408 Common - histidine kinase Sare_1783 141 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 159040132 Common - peptidase C60 sortase A and B Sare_4636 16 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 159039443 Nonpathogen - hypothetical protein Sare_3914 1 None None None 159036929 Common - hypothetical protein Sare_1288 10 None None None 159039484 Common - hypothetical protein Sare_3956 5 None None None 159036489 Common - Phosphopyruvate hydratase Sare_0833 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 159039109 Common - excisionase/Xis, DNA-binding Sare_3570 5 None None None 159039189 Common - aldo/keto reductase Sare_3653 190 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 159038819 Nonpathogen - hypothetical protein Sare_3278 2 None None None 159035950 Common - Enoyl-CoA hydratase/isomerase Sare_0281 178 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 159037607 Nonpathogen - hypothetical protein Sare_1987 1 None None None 159039372 Common - GTP-binding protein LepA Sare_3841 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 159037283 Common - diguanylate cyclase Sare_1657 176 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 159037767 Common - Methyltransferase type 12 Sare_2165 32 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 159039738 Common - CDP-alcohol phosphatidyltransferase Sare_4219 141 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 159037181 Common - helix-turn-helix domain protein Sare_1547 6 None None None 159040526 Common - aminoglycoside phosphotransferase Sare_5045 69 COG3001 COG3001, Uncharacterized protein conserved in bacteria Function unknown 159038905 Common - helix-turn-helix domain protein Sare_3365 6 None None None 159035982 Common - peptidase S8 and S53 subtilisin kexin sedolisin Sare_0314 98 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 159036788 Common - monooxygenase FAD-binding Sare_1142 67 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 159038159 Common - CRISPR-associated protein Cas2 Sare_2579 26 None None None 159037291 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Sare_1665 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 159037216 Common - hypothetical protein Sare_1583 6 None None None 159039828 Common - ribosomal protein S3 Sare_4309 248 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 159036827 Common - chromosome segregation protein SMC Sare_1181 178 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 159038918 Common - response regulator receiver and ANTAR domain protein Sare_3378 136 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 159037873 Nonpathogen - OsmC family protein Sare_2276 1 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 159040498 Common - protein of unknown function DUF485 Sare_5017 19 COG3162 COG3162, Predicted membrane protein Function unknown 159035915 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_0243 55 COG3607 COG3607, Predicted lactoylglutathione lyase General function prediction only 159036182 Common - nitroreductase Sare_0515 13 COG0778 NfnB, Nitroreductase Energy production and conversion 159037838 Common - catalytic domain of components of various dehydrogenase complexes Sare_2240 194 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 159036540 Nonpathogen - hypothetical protein Sare_0884 3 None None None 159036328 Common - short-chain dehydrogenase/reductase SDR Sare_0668 99 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 159038861 Common - hypothetical protein Sare_3320 18 COG3429 COG3429, Glucose-6-P dehydrogenase subunit Carbohydrate transport and metabolism 159038875 Common - hypothetical protein Sare_3334 6 None None None 159038682 Nonpathogen - hypothetical protein Sare_3136 1 None None None 159037760 Common - transcriptional regulator, AraC family Sare_2157 137 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 159035739 Common - Zn-dependent hydrolase of the beta-lactamase fold-like protein Sare_0065 46 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 159038519 Common - thiamine pyrophosphate protein domain protein TPP-binding Sare_2955 220 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 159040479 Common - Mg2 transporter protein CorA family protein Sare_4998 157 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 159039354 Common - cobalt transport protein Sare_3823 51 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 159038263 Common - acetyl-CoA carboxylase, biotin carboxyl carrier protein Sare_2688 169 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 159036818 Common - pantetheine-phosphate adenylyltransferase Sare_1172 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 159038556 Nonpathogen - hypothetical protein Sare_2994 1 None None None 159036758 Common - glutamyl-tRNA(Gln) amidotransferase, A subunit Sare_1112 221 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 159035727 Common - serine/threonine protein kinase with PASTA sensor(s) Sare_0053 157 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 159036884 Common - multicopper oxidase type 2 Sare_1241 75 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 159037735 Nonpathogen - hypothetical protein Sare_2132 1 None None None 159040153 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Sare_4662 67 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 159039811 Common - protein of unknown function DUF1707 Sare_4292 7 None None None 159039984 Common - phenylacetate-CoA oxygenase, PaaG subunit Sare_4472 46 COG3396 COG3396, Uncharacterized conserved protein Function unknown 159037231 Nonpathogen - hypothetical protein Sare_1600 3 None None None 159039450 Common - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Sare_3921 118 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 159039929 Common - DEAD/DEAH box helicase domain protein Sare_4414 98 COG1205 COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster General function prediction only 159035703 Common - peptidase S8 and S53 subtilisin kexin sedolisin Sare_0029 103 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 159035855 Common - hypothetical protein Sare_0182 7 None None None 159036860 Common - cell divisionFtsK/SpoIIIE Sare_1215 16 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 159037922 Common - ATP-dependent transcriptional regulator, MalT-like, LuxR family Sare_2326 45 COG2909 MalT, ATP-dependent transcriptional regulator Transcription 159040505 Common - histidine kinase Sare_5024 219 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 159036189 Common - CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase Sare_0522 182 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 159039587 Common - Patatin Sare_4059 40 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 159039788 Common - NMT1/THI5 like domain protein Sare_4269 86 COG0715 TauA, ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components Inorganic ion transport and metabolism 159040393 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_4906 26 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 159036046 Common - transcriptional regulator, XRE family Sare_0379 24 COG1396 HipB, Predicted transcriptional regulators Transcription 159038560 Common - GntR domain protein Sare_2998 121 COG2186 FadR, Transcriptional regulators Transcription 159040455 Common - hypothetical protein Sare_4971 7 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 159039339 Common - hypothetical protein Sare_3808 5 None None None 159037627 Common - dTDP-4-dehydrorhamnose reductase Sare_2017 166 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 159038826 Common - hypothetical protein Sare_3285 3 None None None 159036194 Common - dienelactone hydrolase Sare_0527 28 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 159038369 Common - transcriptional regulator, PadR-like family Sare_2796 30 COG1695 COG1695, Predicted transcriptional regulators Transcription 159035799 Common - Spermine synthase Sare_0126 116 COG4262 COG4262, Predicted spermidine synthase with an N-terminal membrane domain General function prediction only 159037530 Nonpathogen - hypothetical protein Sare_1907 1 None None None 159037614 Nonpathogen - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_1999 1 None None None 159040426 Common - Choline dehydrogenase Sare_4942 92 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 159039416 Common - GCN5-related N-acetyltransferase Sare_3887 21 COG4552 Eis, Predicted acetyltransferase involved in intracellular survival and related acetyltransferases General function prediction only 159039117 Nonpathogen - hypothetical protein Sare_3579 5 None None None 159039523 Common - hypothetical protein Sare_3995 16 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 159040184 Nonpathogen - hypothetical protein Sare_4693 1 None None None 159037149 Nonpathogen - Collagen triple helix repeat Sare_1515 1 COG5373 COG5373, Predicted membrane protein Function unknown 159037125 Common - ATP dependent DNA ligase Sare_1489 86 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 159035760 Nonpathogen - hypothetical protein Sare_0087 4 None None None 159035920 Common - transcriptional regulator, XRE family Sare_0250 5 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 159040469 Nonpathogen - hypothetical protein Sare_4988 1 None None None 159037411 Common - protein of unknown function DUF397 Sare_1786 6 None None None 159039095 Common - transcriptional regulator, MerR family Sare_3555 117 COG0789 SoxR, Predicted transcriptional regulators Transcription 159040023 Common - 4-hydroxybenzoate polyprenyltransferase, putative Sare_4513 155 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 159038426 Common - Integrase catalytic region Sare_2854 75 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 159037272 Common - hypothetical protein Sare_1642 4 None None None 159037802 Common - hypothetical protein Sare_2203 14 None None None 159037653 Common - transcriptional regulator, ArsR family Sare_2048 73 COG0640 ArsR, Predicted transcriptional regulators Transcription 159037798 Common - transcriptional regulator, HxlR family Sare_2199 74 COG1733 COG1733, Predicted transcriptional regulators Transcription 159039519 Common - acetyl-CoA acetyltransferase Sare_3991 181 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 159037721 Common - C-methyltransferase Sare_2118 42 COG4976 COG4976, Predicted methyltransferase (contains TPR repeat) General function prediction only 159038306 Common - molybdate ABC transporter, inner membrane subunit Sare_2733 173 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 159038469 Common - ribosomal protein S14 Sare_2905 187 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 159039368 Common - hypothetical protein Sare_3837 14 COG3296 COG3296, Uncharacterized protein conserved in bacteria Function unknown 159038936 Common - tryptophan synthase, beta subunit Sare_3396 224 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 159036681 Common - Platelet-activating factor acetylhydrolase plasma/intracellular isoform II Sare_1034 10 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 159037992 Common - transcriptional regulator, AsnC family Sare_2396 153 COG1522 Lrp, Transcriptional regulators Transcription 159035884 Common - glycosyl transferase group 1 Sare_0211 130 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159040053 Common - pyruvate phosphate dikinase PEP/pyruvate-binding Sare_4547 141 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 159037020 Nonpathogen - transcriptional regulator, LuxR family Sare_1382 8 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159039426 Common - 3-hydroxyanthranilate 3,4-dioxygenase Sare_3897 16 None None None 159035936 Common - aspartate-semialdehyde dehydrogenase Sare_0266 216 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 159036149 Common - Alpha/beta hydrolase fold-3 domain protein Sare_0482 124 COG0657 Aes, Esterase/lipase Lipid metabolism 159038446 Common - Oxidoreductase FAD-binding domain protein Sare_2882 141 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 159037591 Common - Integrase catalytic region Sare_1968 75 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 159039166 Common - hypothetical protein Sare_3630 29 COG3973 COG3973, Superfamily I DNA and RNA helicases General function prediction only 159038231 Nonpathogen - hypothetical protein Sare_2656 1 None None None 159036442 Common - ABC transporter transmembrane region Sare_0785 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 159039508 Common - putative sensor with HAMP domain Sare_3980 12 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159037153 Common - 8-amino-7-oxononanoate synthase Sare_1519 186 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 159038374 Common - short-chain dehydrogenase/reductase SDR Sare_2801 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159036089 Common - Haloacid dehalogenase domain protein hydrolase Sare_0422 7 COG0546 Gph, Predicted phosphatases General function prediction only 159037333 Common - transcriptional regulator, LysR family Sare_1708 191 COG0583 LysR, Transcriptional regulator Transcription 159035755 Common - luciferase family protein Sare_0082 10 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 159036424 Common - ABC transporter CydDC cysteine exporter (CydDC-E) family permease/ATP-binding protein CydD Sare_0767 249 COG4988 CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 159036729 Common - glycoside hydrolase family 85 Sare_1083 18 COG4724 COG4724, Endo-beta-N-acetylglucosaminidase D Carbohydrate transport and metabolism 159039320 Nonpathogen - hypothetical protein Sare_3789 1 None None None 159035931 Common - hypothetical protein Sare_0261 24 None None None 159038643 Common - conserved hypothetical protein; putative helicase Sare_3092 57 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 159038967 Common - pseudouridine synthase, RluA family Sare_3427 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 159035684 Common - transcriptional regulator, XRE family Sare_0010 6 COG1396 HipB, Predicted transcriptional regulators Transcription 159040348 Common - two component transcriptional regulator, LuxR family Sare_4860 181 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159036220 Common - flavin reductase domain protein FMN-binding Sare_0553 112 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 159038381 Common - acyl-CoA dehydrogenase domain protein Sare_2808 155 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159036727 Common - binding-protein-dependent transport systems inner membrane component Sare_1081 152 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 159037246 Common - hypothetical protein Sare_1615 49 None None None 159035696 Common - hypothetical protein Sare_0022 4 None None None 159037160 Common - NAD-dependent epimerase/dehydratase Sare_1526 13 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 159035691 Common - Hemolysin-type calcium-binding region Sare_0017 77 None None None 159038280 Common - precorrin-4 C11-methyltransferase Sare_2705 200 COG2875 CobM, Precorrin-4 methylase Coenzyme metabolism 159035953 Nonpathogen - phosphoesterase PA-phosphatase related Sare_0284 1 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 159038116 Common - geranylgeranyl reductase Sare_2536 102 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 159038450 Common - acyl-CoA dehydrogenase domain protein Sare_2886 147 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159040061 Common - Thioesterase Sare_4555 49 COG3208 GrsT, Predicted thioesterase involved in non-ribosomal peptide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 159039522 Common - crotonyl-CoA reductase Sare_3994 176 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 159036234 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sare_0568 50 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159037982 Common - hypothetical protein Sare_2386 19 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 159038179 Common - glycoside hydrolase family 3 domain protein Sare_2600 120 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 159039288 Nonpathogen - hypothetical protein Sare_3757 1 None None None 159038037 Common - aminotransferase class I and II Sare_2452 225 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 159039795 Nonpathogen - thiamine monophosphate synthase Sare_4276 15 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 159038994 Common - cation antiporter Sare_3454 46 COG1863 MnhE, Multisubunit Na+/H+ antiporter, MnhE subunit Inorganic ion transport and metabolism 159037598 Common - CRISPR-associated protein Cas5 family Sare_1975 41 None None None 159037885 Common - GCN5-related N-acetyltransferase Sare_2289 59 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 159036326 Nonpathogen - hypothetical protein Sare_0666 2 None None None 159037183 Common - SpoOM family protein Sare_1549 20 COG4326 Spo0M, Sporulation control protein General function prediction only 159035968 Nonpathogen - hypothetical protein Sare_0300 1 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 159036538 Common - Mannose-1-phosphate guanylyltransferase (GDP) Sare_0882 161 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 159040405 Nonpathogen - hypothetical protein Sare_4919 1 None None None 159037047 Common - transcriptional repressor, LexA family Sare_1409 173 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 159038834 Common - transcriptional regulator, TetR family Sare_3293 44 COG1309 AcrR, Transcriptional regulator Transcription 159040306 Common - RNA-binding S4 domain protein Sare_4818 232 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 159037813 Nonpathogen - hypothetical protein Sare_2214 1 None None None 159038589 Nonpathogen - hypothetical protein Sare_3029 1 None None None 159040472 Nonpathogen - hypothetical protein Sare_4991 1 None None None 159037509 Common - arginine repressor, ArgR Sare_1886 79 COG1438 ArgR, Arginine repressor Transcription 159037365 Common - cyclase/dehydrase Sare_1740 32 COG5637 COG5637, Predicted integral membrane protein Function unknown 159035677 Common - 6-phosphogluconate dehydrogenase, decarboxylating Sare_0003 184 COG1023 Gnd, Predicted 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 159039549 Common - glycosyl transferase family 51 Sare_4021 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 159039576 Common - hypothetical protein Sare_4048 12 None None None 159038320 Common - GTP cyclohydrolase II Sare_2747 177 COG0807 RibA, GTP cyclohydrolase II Coenzyme metabolism 159040119 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_4623 40 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 159039173 Nonpathogen - hypothetical protein Sare_3637 2 None None None 159035790 Nonpathogen - hypothetical protein Sare_0117 1 None None None 159036837 Common - amidohydrolase Sare_1191 49 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 159040561 Common - Myo-inositol-1-phosphate synthase Sare_5081 54 COG1260 INO1, Myo-inositol-1-phosphate synthase Lipid metabolism 159036903 Common - cytochrome P450 Sare_1260 86 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159036482 Common - Tripeptidyl-peptidase II Sare_0826 47 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 159040568 Nonpathogen - hypothetical protein Sare_5088 1 None None None 159038972 Common - DivIVA family protein Sare_3432 37 COG3599 DivIVA, Cell division initiation protein Cell division and chromosome partitioning 159037896 Common - transcriptional regulator, TraR/DksA family Sare_2300 120 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 159040018 Common - DEAD/DEAH box helicase domain protein Sare_4508 232 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 159037634 Nonpathogen - hypothetical protein Sare_2026 1 None None None 159038730 Common - monooxygenase FAD-binding Sare_3185 88 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 159039122 Common - glutamine synthetase, type I Sare_3584 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 159038417 Common - hypothetical protein Sare_2844 15 None None None 159037116 Common - cytochrome c biogenesis protein transmembrane region Sare_1480 6 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 159038336 Common - hypothetical protein Sare_2763 6 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 159040414 Common - Zeta-phytoene desaturase Sare_4929 79 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159037137 Common - plasmid pRiA4b ORF-3 family protein Sare_1501 43 None None None 159038237 Common - Alpha/beta hydrolase fold-3 domain protein Sare_2662 128 COG0657 Aes, Esterase/lipase Lipid metabolism 159038737 Common - Haloacid dehalogenase domain protein hydrolase Sare_3192 29 COG0546 Gph, Predicted phosphatases General function prediction only 159036855 Common - DNA protecting protein DprA Sare_1209 208 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 159040127 Common - bifunctional deaminase-reductase domain protein Sare_4631 40 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 159040525 Common - hypothetical protein Sare_5044 5 None None None 159037454 Common - Oligosaccharide biosynthesis protein Alg14-like protein Sare_1830 7 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 159038030 Common - transcriptional regulator, SARP family Sare_2444 12 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 159039193 Nonpathogen - hypothetical protein Sare_3658 1 None None None 159036455 Common - serine/threonine protein kinase Sare_0798 152 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 159035974 Common - GCN5-related N-acetyltransferase Sare_0306 7 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 159039706 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Sare_4179 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 159039230 Nonpathogen - hypothetical protein Sare_3699 1 None None None 159039678 Common - Succinate dehydrogenase Sare_4150 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 159039801 Common - ABC transporter related Sare_4282 225 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 159038618 Common - Pyridoxal-5'-phosphate-dependent protein beta subunit Sare_3061 224 COG1350 COG1350, Predicted alternative tryptophan synthase beta-subunit (paralog of TrpB) General function prediction only 159037947 Common - ABC transporter related Sare_2351 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 159038196 Common - ABC transporter related Sare_2618 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 159037317 Common - hypothetical protein Sare_1692 203 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 159036229 Common - NADH:flavin oxidoreductase/NADH oxidase Sare_0563 176 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 159037776 Common - protein of unknown function DUF1702 Sare_2176 3 COG3249 COG3249, Uncharacterized protein conserved in bacteria Function unknown 159037391 Common - adenosine deaminase Sare_1766 111 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 159039542 Common - ATP synthase F1, alpha subunit Sare_4014 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 159036140 Common - NADH dehydrogenase (quinone) Sare_0473 130 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 159040395 Common - transcriptional regulator, XRE family Sare_4908 6 COG1476 COG1476, Predicted transcriptional regulators Transcription 159038711 Common - transcriptional regulator, TetR family Sare_3165 31 COG1309 AcrR, Transcriptional regulator Transcription 159036495 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_0839 35 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 159037632 Common - cytochrome P450 Sare_2024 69 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159035896 Common - protein of unknown function DUF214 Sare_0223 183 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 159039240 Nonpathogen - hypothetical protein Sare_3709 1 None None None 159039646 Common - transcription factor WhiB Sare_4118 14 None None None 159039612 Nonpathogen - hypothetical protein Sare_4084 4 COG3677 COG3677, Transposase and inactivated derivatives DNA replication, recombination, and repair 159037417 Common - hypothetical protein Sare_1793 63 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 159037395 Common - threonyl-tRNA synthetase Sare_1770 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159038136 Nonpathogen - hypothetical protein Sare_2556 1 None None None 159036262 Common - hypothetical protein Sare_0596 10 None None None 159037895 Common - putative two component transcriptional regulator, winged helix family Sare_2299 192 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159036116 Common - hypothetical protein Sare_0449 34 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 159037066 Common - ABC transporter related Sare_1429 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 159039501 Common - xylose isomerase Sare_3973 78 COG2115 XylA, Xylose isomerase Carbohydrate transport and metabolism 159036170 Nonpathogen - hypothetical protein Sare_0503 1 None None None 159038649 Common - hypothetical protein Sare_3100 7 None None None 159038708 Common - cytochrome P450 Sare_3162 65 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159039169 Nonpathogen - anti-sigma-factor antagonist Sare_3633 6 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 159040267 Common - MlrC domain protein Sare_4776 31 COG5476 COG5476, Uncharacterized conserved protein Function unknown 159036593 Nonpathogen - protein of unknown function DUF571 Sare_0940 4 COG5100 NPL4, Nuclear pore protein Nuclear structure 159035871 Common - Methyltransferase type 11 Sare_0198 152 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159038565 Common - Mandelate racemase/muconate lactonizing protein Sare_3003 120 COG4948 COG4948, L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily Cell envelope biogenesis, outer membrane / General function prediction only 159039070 Common - anthranilate phosphoribosyltransferase Sare_3530 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 159035853 Nonpathogen - transcriptional regulator, XRE family Sare_0180 5 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 159037673 Common - 3-Oxoacyl-(acyl-carrier-protein (ACP)) synthase III domain protein Sare_2069 178 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 159040015 Common - Radical SAM domain protein Sare_4505 81 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 159039966 Common - NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Sare_4454 71 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 159037055 Common - hypothetical protein Sare_1417 11 None None None 159038056 Nonpathogen - hypothetical protein Sare_2474 1 None None None 159038412 Common - protein of unknown function DUF35 Sare_2839 16 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 159035814 Common - major facilitator superfamily MFS_1 Sare_0141 6 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159035845 Common - 3-hydroxybutyryl-CoA dehydrogenase Sare_0172 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 159036844 Common - ribosomal protein L19 Sare_1198 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 159036205 Nonpathogen - sodium/calcium exchanger membrane region Sare_0538 20 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 159038461 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_2897 15 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 159035835 Common - hypothetical protein Sare_0162 18 COG3255 COG3255, Putative sterol carrier protein Lipid metabolism 159039438 Common - peptidase C60 sortase A and B Sare_3909 14 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 159038753 Nonpathogen - hypothetical protein Sare_3208 1 None None None 159039554 Common - peptide chain release factor 1 Sare_4026 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 159039361 Common - CBS domain containing protein Sare_3830 218 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 159036342 Common - hypothetical protein Sare_0683 17 COG2887 COG2887, RecB family exonuclease DNA replication, recombination, and repair 159036850 Common - transcriptional regulator, ArsR family Sare_1204 106 COG0640 ArsR, Predicted transcriptional regulators Transcription 159039215 Nonpathogen - hypothetical protein Sare_3684 1 None None None 159036969 Common - phosphoesterase RecJ domain protein Sare_1330 55 COG0618 COG0618, Exopolyphosphatase-related proteins General function prediction only 159038779 Common - protein of unknown function DUF397 Sare_3236 6 None None None 159036285 Nonpathogen - hypothetical protein Sare_0622 1 None None None 159038785 Nonpathogen - hypothetical protein Sare_3243 1 None None None 159036522 Common - transcription elongation factor GreA Sare_0866 195 COG0782 GreA, Transcription elongation factor Transcription 159038492 Common - VWA containing CoxE family protein Sare_2928 25 COG2425 COG2425, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 159036985 Common - thymidylate synthase, flavin-dependent Sare_1346 47 COG1351 THY1, Predicted alternative thymidylate synthase Nucleotide transport and metabolism 159038143 Common - protein of unknown function DUF1622 Sare_2563 8 COG4828 COG4828, Predicted membrane protein Function unknown 159036398 Common - tryptophanyl-tRNA synthetase Sare_0741 229 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159039402 Common - valyl-tRNA synthetase Sare_3872 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159039044 Common - flavin-containing monooxygenase FMO Sare_3504 78 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 159036980 Common - Dihydrodipicolinate reductase Sare_1341 216 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 159039902 Common - regulator of chromosome condensation RCC1 Sare_4383 32 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 159040254 Common - transcriptional regulator, TetR family Sare_4763 17 COG1309 AcrR, Transcriptional regulator Transcription 159035786 Common - GrpE protein Sare_0113 155 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 159039160 Common - Propionyl-CoA carboxylase Sare_3624 168 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 159038359 Nonpathogen - hypothetical protein Sare_2786 2 COG5660 COG5660, Predicted integral membrane protein Function unknown 159040150 Common - cysteinyl-tRNA synthetase Sare_4659 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159036013 Common - regulatory protein GntR HTH Sare_0345 15 COG2186 FadR, Transcriptional regulators Transcription 159036457 Nonpathogen - RNA polymerase, sigma-24 subunit, ECF subfamily Sare_0800 4 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159038069 Common - Inositol 2-dehydrogenase Sare_2488 173 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 159039293 Nonpathogen - hypothetical protein Sare_3762 1 None None None 159039632 Nonpathogen - hypothetical protein Sare_4104 1 None None None 159036352 Common - GCN5-related N-acetyltransferase Sare_0694 100 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 159035827 Common - adenylosuccinate lyase Sare_0154 182 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 159038181 Common - helix-turn-helix domain protein Sare_2602 6 None None None 159039211 Common - transcriptional regulator, PadR-like family Sare_3679 14 COG1695 COG1695, Predicted transcriptional regulators Transcription 159038154 Common - CRISPR-associated protein, Cse2 family Sare_2574 6 None None None 159036529 Common - phosphoribosylaminoimidazole carboxylase, catalytic subunit Sare_0873 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 159037786 Nonpathogen - hypothetical protein Sare_2186 1 None None None 159035962 Common - Microtubule-severing ATPase Sare_0293 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 159037108 Nonpathogen - hypothetical protein Sare_1472 1 COG5373 COG5373, Predicted membrane protein Function unknown 159039954 Common - protein of unknown function DUF909 Sare_4442 3 COG4842 COG4842, Uncharacterized protein conserved in bacteria Function unknown 159040280 Common - Endoribonuclease L-PSP Sare_4789 101 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 159036009 Common - protein of unknown function DUF1416 Sare_0341 10 None None None 159036350 Common - Nucleotidyl transferase Sare_0692 232 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 159037478 Common - DNA-directed RNA polymerase, omega subunit Sare_1855 22 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 159039877 Common - AMP-dependent synthetase and ligase Sare_4358 222 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159037856 Common - hypothetical protein Sare_2259 65 COG4301 COG4301, Uncharacterized conserved protein Function unknown 159039853 Common - ribosomal protein L33 Sare_4334 86 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 159036714 Nonpathogen - hypothetical protein Sare_1067 2 None None None 159036124 Common - glutamate 5-kinase Sare_0457 189 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 159036581 Common - protein of unknown function DUF397 Sare_0927 6 None None None 159036668 Common - hypothetical protein Sare_1019 7 None None None 159039928 Common - anti-sigma-factor antagonist Sare_4413 67 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 159040343 Nonpathogen - hypothetical protein Sare_4855 1 None None None 159039716 Common - phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Sare_4197 218 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 159039990 Common - CRISPR-associated helicase Cas3, Anaes-subtype Sare_4478 28 COG1203 COG1203, Predicted helicases General function prediction only 159038296 Nonpathogen - hypothetical protein Sare_2721 2 None None None 159037961 Nonpathogen - hypothetical protein Sare_2365 1 None None None 159037486 Common - Fmu (Sun) domain protein Sare_1863 184 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 159035843 Common - DNA binding domain, excisionase family Sare_0170 13 COG2452 COG2452, Predicted site-specific integrase-resolvase DNA replication, recombination, and repair 159036941 Common - 1-deoxy-D-xylulose 5-phosphate reductoisomerase Sare_1302 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 159037671 Common - thiamine pyrophosphate protein TPP binding domain protein Sare_2067 220 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 159036640 Common - cysteine synthase Sare_0991 222 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 159037935 Common - NAD-dependent epimerase/dehydratase Sare_2339 73 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 159039266 Common - pentapeptide repeat protein Sare_3735 55 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 159037004 Common - DEAD/H associated domain protein Sare_1365 152 COG1201 Lhr, Lhr-like helicases General function prediction only 159036177 Common - putative phosphoserine aminotransferase Sare_0510 160 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 159040320 Nonpathogen - protein of unknown function DUF909 Sare_4832 1 COG4842 COG4842, Uncharacterized protein conserved in bacteria Function unknown 159038275 Common - Precorrin-8X methylmutase CbiC/CobH Sare_2700 116 COG2082 CobH, Precorrin isomerase Coenzyme metabolism 159037435 Common - fatty acid desaturase type 2 Sare_1811 10 None None None 159037009 Common - SpoOM family protein Sare_1370 17 COG4326 Spo0M, Sporulation control protein General function prediction only 159039556 Common - transcription termination factor Rho Sare_4028 210 COG1158 Rho, Transcription termination factor Transcription 159037029 Common - RNA binding metal dependent phosphohydrolase Sare_1391 77 COG1418 COG1418, Predicted HD superfamily hydrolase General function prediction only 159039624 Common - hypothetical protein Sare_4096 12 COG3571 COG3571, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 159037238 Common - carbonic anhydrase Sare_1607 112 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 159038355 Common - ABC transporter related Sare_2782 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159040480 Common - putative transcriptional regulator, GntR family Sare_4999 217 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 159038079 Nonpathogen - GYD family protein Sare_2498 10 COG4274 COG4274, Uncharacterized conserved protein Function unknown 159039464 Nonpathogen - hypothetical protein Sare_3936 1 None None None 159039145 Common - hypothetical protein Sare_3609 16 None None None 159038744 Nonpathogen - hypothetical protein Sare_3199 1 None None None 159038218 Common - Sua5/YciO/YrdC/YwlC family protein Sare_2642 211 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 159038695 Common - cytochrome P450 Sare_3149 78 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159040045 Common - PEBP family protein Sare_4535 120 COG1881 COG1881, Phospholipid-binding protein General function prediction only 159037114 Common - transcriptional regulator, LysR family Sare_1478 192 COG0583 LysR, Transcriptional regulator Transcription 159037851 Common - protein of unknown function DUF305 Sare_2254 35 COG3544 COG3544, Uncharacterized protein conserved in bacteria Function unknown 159039944 Common - HAD-superfamily subfamily IB hydrolase, TIGR01490 Sare_4432 69 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 159040206 Common - L-aspartate oxidase Sare_4715 226 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 159035797 Common - protein of unknown function DUF350 Sare_0124 10 None None None 159036436 Common - beta-lactamase domain protein Sare_0779 16 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 159036866 Common - NUDIX hydrolase Sare_1221 37 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 159040435 Common - Beta-ketoacyl synthase Sare_4951 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159036275 Nonpathogen - hypothetical protein Sare_0609 1 None None None 159037256 Common - glycine betaine/L-proline ABC transporter, ATPase subunit Sare_1626 249 COG4175 ProV, ABC-type proline/glycine betaine transport system, ATPase component Amino acid transport and metabolism 159040172 Nonpathogen - RDD domain containing protein Sare_4681 1 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 159039918 Common - DNA polymerase III, delta prime subunit Sare_4403 216 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 159040509 Nonpathogen - hypothetical protein Sare_5028 4 None None None 159038346 Common - FAD dependent oxidoreductase Sare_2773 137 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 159039978 Nonpathogen - LPXTG-motif cell wall anchor domain Sare_4466 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 159040195 Common - amidohydrolase Sare_4704 79 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 159037701 Common - 4-hydroxyphenylacetate 3-hydroxylase Sare_2098 50 COG2368 COG2368, Aromatic ring hydroxylase Secondary metabolites biosynthesis, transport, and catabolism 159038011 Common - hypothetical protein Sare_2417 14 None None None 159039506 Nonpathogen - protein of unknown function DUF742 Sare_3978 3 None None None 159039752 Common - hypothetical protein Sare_4233 18 COG4076 COG4076, Predicted RNA methylase General function prediction only 159037022 Common - two component transcriptional regulator, winged helix family Sare_1384 222 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159038213 Common - protein of unknown function DUF817 Sare_2636 24 COG3739 COG3739, Uncharacterized integral membrane protein Function unknown 159038472 Nonpathogen - Hemerythrin HHE cation binding domain protein Sare_2908 5 None None None 159039453 Common - hypothetical protein Sare_3924 22 COG3346 COG3346, Uncharacterized conserved protein Function unknown 159036686 Common - transcriptional regulator, TetR family Sare_1039 9 COG1309 AcrR, Transcriptional regulator Transcription 159036065 Common - glycosyl transferase group 1 Sare_0398 163 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159040453 Common - type II secretion system protein Sare_4969 9 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 159037905 Nonpathogen - hypothetical protein Sare_2309 1 None None None 159039015 Common - Zeta-phytoene desaturase Sare_3475 63 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159040487 Common - Undecaprenyl-phosphate galactose phosphotransferase Sare_5006 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 159038786 Common - band 7 protein Sare_3244 218 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 159040371 Common - peptidase S45 penicillin amidase Sare_4884 76 COG2366 COG2366, Protein related to penicillin acylase General function prediction only 159039844 Common - DNA-directed RNA polymerase, beta subunit Sare_4325 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 159037379 Nonpathogen - hypothetical protein Sare_1754 1 None None None 159036501 Common - ATPase associated with various cellular activities AAA_3 Sare_0845 172 COG0714 COG0714, MoxR-like ATPases General function prediction only 159039084 Common - hypothetical protein Sare_3544 8 None None None 159036643 Common - ribonuclease PH Sare_0994 179 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 159035822 Nonpathogen - hypothetical protein Sare_0149 1 None None None 159037322 Nonpathogen - hypothetical protein Sare_1697 1 None None None 159039580 Common - amidinotransferase Sare_4052 42 COG1834 COG1834, N-Dimethylarginine dimethylaminohydrolase Amino acid transport and metabolism 159040287 Common - glycosyl transferase family 51 Sare_4796 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 159036087 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sare_0420 149 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159040466 Common - Transketolase domain protein Sare_4985 104 COG3959 COG3959, Transketolase, N-terminal subunit Carbohydrate transport and metabolism 159037956 Common - protein of unknown function DUF797 Sare_2360 14 None None None 159038251 Nonpathogen - hypothetical protein Sare_2676 1 None None None 159038602 Common - dienelactone hydrolase Sare_3045 42 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 159038664 Common - hypothetical protein Sare_3118 4 None None None 159039033 Common - binding-protein-dependent transport systems inner membrane component Sare_3493 140 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 159040246 Nonpathogen - phosphoesterase PA-phosphatase related Sare_4755 3 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 159036606 Common - putative RNA polymerase, sigma-24 subunit, ECF subfamily Sare_0956 41 COG4941 COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain Transcription 159039681 Nonpathogen - hypothetical protein Sare_4153 1 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 159036479 Common - exodeoxyribonuclease VII, large subunit Sare_0823 203 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 159039077 Common - Glycerate kinase Sare_3537 81 COG1929 COG1929, Glycerate kinase Carbohydrate transport and metabolism 159038322 Common - glycosyl transferase group 1 Sare_2749 80 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159039046 Common - putative glucokinase, ROK family Sare_3506 155 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 159039741 Common - phage shock protein C, PspC Sare_4222 15 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 159040308 Common - hypothetical protein Sare_4820 121 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 159039031 Common - N-acylglucosamine 2-epimerase Sare_3491 36 COG2942 COG2942, N-acyl-D-glucosamine 2-epimerase Carbohydrate transport and metabolism 159037651 Common - hypothetical protein Sare_2046 18 None None None 159036999 Common - Fibronectin type III domain protein Sare_1360 18 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 159040232 Nonpathogen - cell divisionFtsK/SpoIIIE Sare_4741 6 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 159038118 Common - cytochrome P450 Sare_2538 78 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159037550 Nonpathogen - hypothetical protein Sare_1927 1 None None None 159038977 Common - Polypeptide-transport-associated domain protein FtsQ-type Sare_3437 27 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 159037815 Nonpathogen - hypothetical protein Sare_2217 2 None None None 159040239 Common - tRNA(Ile)-lysidine synthetase Sare_4748 44 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 159036359 Common - Methyltransferase type 11 Sare_0702 20 COG2519 GCD14, tRNA(1-methyladenosine) methyltransferase and related methyltransferases Translation, ribosomal structure and biogenesis 159038402 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Sare_2829 11 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 159037916 Common - hypothetical protein Sare_2320 17 None None None 159039993 Nonpathogen - hypothetical protein Sare_4483 1 None None None 159039547 Common - hypothetical protein Sare_4019 5 COG5336 COG5336, Uncharacterized protein conserved in bacteria Function unknown 159038799 Common - phosphoesterase PA-phosphatase related Sare_3258 5 None None None 159037346 Common - exodeoxyribonuclease III Xth Sare_1721 196 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 159039496 Common - binding-protein-dependent transport systems inner membrane component Sare_3968 155 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 159036639 Common - thiamineS protein Sare_0990 37 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 159038341 Nonpathogen - hypothetical protein Sare_2768 1 None None None 159036801 Common - hypothetical protein Sare_1155 11 COG1920 COG1920, Uncharacterized conserved protein Function unknown 159040037 Common - Pyridoxal-5'-phosphate-dependent protein beta subunit Sare_4527 188 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 159036670 Common - ErfK/YbiS/YcfS/YnhG family protein Sare_1021 23 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 159036311 Nonpathogen - hypothetical protein Sare_0651 1 None None None 159036763 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Sare_1117 230 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 159036102 Common - Methyltransferase type 11 Sare_0435 18 COG4627 COG4627, Uncharacterized protein conserved in bacteria Function unknown 159037589 Nonpathogen - hypothetical protein Sare_1966 1 None None None 159036153 Common - Orn/DAP/Arg decarboxylase 2 Sare_0486 217 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 159036237 Common - L-lysine 6-monooxygenase (NADPH) Sare_0571 54 COG3486 IucD, Lysine/ornithine N-monooxygenase Secondary metabolites biosynthesis, transport, and catabolism 159040562 Nonpathogen - hypothetical protein Sare_5082 1 None None None 159040063 Common - cytochrome P450 Sare_4557 91 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159035874 Common - aldehyde oxidase and xanthine dehydrogenase molybdopterin binding Sare_0201 115 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 159036318 Common - O-methyltransferase family 3 Sare_0658 87 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 159039255 Nonpathogen - hypothetical protein Sare_3724 1 None None None 159040101 Nonpathogen - hypothetical protein Sare_4605 2 None None None 159040402 Nonpathogen - hypothetical protein Sare_4916 1 None None None 159038000 Common - periplasmic binding protein Sare_2404 68 COG4607 CeuA, ABC-type enterochelin transport system, periplasmic component Inorganic ion transport and metabolism 159036951 Nonpathogen - hypothetical protein Sare_1312 1 None None None 159036256 Common - glutamate racemase Sare_0590 187 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 159039142 Common - alpha/beta hydrolase fold Sare_3606 176 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159039138 Common - zinc finger SWIM domain protein Sare_3602 40 COG4279 COG4279, Uncharacterized conserved protein Function unknown 159040433 Common - cytochrome P450 Sare_4949 81 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159039755 Common - hypothetical protein Sare_4236 83 COG4213 XylF, ABC-type xylose transport system, periplasmic component Carbohydrate transport and metabolism 159040316 Nonpathogen - hypothetical protein Sare_4828 3 None None None 159035917 Nonpathogen - hypothetical protein Sare_0247 1 None None None 159036297 Common - glycoside hydrolase 15-related Sare_0636 72 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 159037698 Common - Caffeoyl-CoA O-methyltransferase Sare_2095 101 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 159038287 Common - transcriptional regulator, CdaR Sare_2712 9 COG3835 CdaR, Sugar diacid utilization regulator Transcription / Signal transduction mechanisms 159036746 Common - thiamine pyrophosphate protein domain protein TPP-binding Sare_1100 219 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 159039852 Common - hypothetical protein Sare_4333 20 COG2030 MaoC, Acyl dehydratase Lipid metabolism 159039261 Nonpathogen - hypothetical protein Sare_3730 1 None None None 159037441 Common - hypothetical protein Sare_1817 7 COG4768 COG4768, Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain General function prediction only 159038916 Common - inner-membrane translocator Sare_3376 150 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 159039768 Common - holo-acyl-carrier-protein synthase Sare_4249 31 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 159036377 Common - glycosyl transferase family 39 Sare_0720 31 COG1928 PMT1, Dolichyl-phosphate-mannose--protein O-mannosyl transferase Posttranslational modification, protein turnover, chaperones 159035800 Nonpathogen - hypothetical protein Sare_0127 1 None None None 159038483 Common - MaoC domain protein dehydratase Sare_2919 75 COG2030 MaoC, Acyl dehydratase Lipid metabolism 159038751 Common - binding-protein-dependent transport systems inner membrane component Sare_3206 142 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 159036372 Common - NADH dehydrogenase (quinone) Sare_0715 180 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 159035792 Common - TrkA-C domain protein Sare_0119 22 COG0490 COG0490, Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels Inorganic ion transport and metabolism 159038045 Common - transcriptional regulator, XRE family Sare_2462 7 COG1396 HipB, Predicted transcriptional regulators Transcription 159038690 Common - hypothetical protein Sare_3144 13 None None None 159037737 Common - transcriptional regulator, TetR family Sare_2134 22 COG1309 AcrR, Transcriptional regulator Transcription 159039476 Common - peptidase M16 domain protein Sare_3948 183 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 159038981 Common - phospho-N-acetylmuramoyl-pentapeptide-transferase Sare_3441 208 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 159035833 Common - putative lipoprotein Sare_0160 9 COG2045 COG2045, Phosphosulfolactate phosphohydrolase and related enzymes Coenzyme metabolism / General function prediction only 159037030 Common - polar amino acid ABC transporter, inner membrane subunit Sare_1392 174 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 159038338 Common - histidine kinase Sare_2765 209 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159039654 Common - NUDIX hydrolase Sare_4126 98 COG2816 NPY1, NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding DNA replication, recombination, and repair 159038333 Common - oxidoreductase molybdopterin binding Sare_2760 37 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 159039606 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Sare_4078 10 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 159039728 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Sare_4209 249 COG4608 AppF, ABC-type oligopeptide transport system, ATPase component Amino acid transport and metabolism 159039884 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Sare_4365 47 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 159040074 Common - Methyltransferase type 12 Sare_4568 2 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 159039469 Common - phospholipid/glycerol acyltransferase Sare_3941 122 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 159037401 Common - hypothetical protein Sare_1776 6 None None None 159039761 Common - ribosomal-protein-alanine acetyltransferase Sare_4242 35 COG0456 RimI, Acetyltransferases General function prediction only 159039969 Common - NADH-quinone oxidoreductase, chain G Sare_4457 199 COG1034 NuoG, NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) Energy production and conversion 159040517 Common - hypothetical protein Sare_5036 12 None None None 159037327 Common - hypothetical protein Sare_1702 3 None None None 159040218 Common - hypothetical protein Sare_4727 2 None None None 159035763 Nonpathogen - ThiJ/PfpI domain protein Sare_0090 5 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 159036792 Nonpathogen - hypothetical protein Sare_1146 1 None None None 159036933 Common - protein of unknown function ATP binding Sare_1292 30 COG2229 COG2229, Predicted GTPase General function prediction only 159039713 Common - transposase IS204/IS1001/IS1096/IS1165 family protein Sare_4192 23 COG3464 COG3464, Transposase and inactivated derivatives DNA replication, recombination, and repair 159038367 Common - Methyltransferase type 11 Sare_2794 75 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159040186 Common - Acyl-CoA dehydrogenase type 2 domain Sare_4695 134 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159037490 Common - riboflavin biosynthesis protein RibD Sare_1867 229 COG1985 RibD, Pyrimidine reductase, riboflavin biosynthesis Coenzyme metabolism 159037211 Common - SRA-YDG domain protein Sare_1577 7 COG3440 COG3440, Predicted restriction endonuclease Defense mechanisms 159039798 Common - glycine oxidase ThiO Sare_4279 126 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 159040167 Nonpathogen - hypothetical protein Sare_4676 1 None None None 159036092 Common - CoA-binding domain protein Sare_0425 56 COG2344 COG2344, AT-rich DNA-binding protein General function prediction only 159038828 Common - hypothetical protein Sare_3287 17 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 159038088 Common - Endonuclease/exonuclease/phosphatase Sare_2507 4 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 159035996 Common - NUDIX hydrolase Sare_0328 28 None None None 159039025 Common - Chitinase Sare_3485 43 COG3325 ChiA, Chitinase Carbohydrate transport and metabolism 159040448 Nonpathogen - hypothetical protein Sare_4964 3 None None None 159039176 Common - seryl-tRNA synthetase Sare_3640 243 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 159038674 Common - hypothetical protein Sare_3128 17 None None None 159037369 Common - FAD dependent oxidoreductase Sare_1744 64 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159039283 Nonpathogen - hypothetical protein Sare_3752 1 None None None 159036562 Common - hypothetical protein Sare_0907 11 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 159039641 Nonpathogen - hypothetical protein Sare_4113 1 None None None 159037304 Common - hypothetical protein Sare_1678 3 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 159036531 Common - UDP-glucose 6-dehydrogenase Sare_0875 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 159038106 Common - CDP-alcohol phosphatidyltransferase Sare_2525 99 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 159036034 Common - ornithine cyclodeaminase/mu-crystallin Sare_0367 55 COG2423 COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog Amino acid transport and metabolism 159036223 Common - hypothetical protein Sare_0556 8 None None None 159039268 Nonpathogen - hypothetical protein Sare_3737 1 None None None 159038326 Common - Methyltransferase type 12 Sare_2753 7 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 159036511 Common - cystathionine beta-synthase Sare_0855 219 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 159036029 Common - amino acid adenylation domain Sare_0362 222 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159037744 Common - hypothetical protein Sare_2141 3 COG3801 COG3801, Uncharacterized protein conserved in bacteria Function unknown 159036852 Common - bifunctional deaminase-reductase domain protein Sare_1206 27 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 159039849 Common - NusG antitermination factor Sare_4330 215 COG0250 NusG, Transcription antiterminator Transcription 159036243 Common - Amidohydrolase 3 Sare_0577 13 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 159035717 Nonpathogen - hypothetical protein Sare_0043 1 None None None 159037647 Common - aminotransferase class V Sare_2039 218 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 159035865 Common - nitrate reductase, alpha subunit Sare_0192 122 COG5013 NarG, Nitrate reductase alpha subunit Energy production and conversion 159036569 Nonpathogen - hypothetical protein Sare_0914 1 None None None 159037079 Common - hypothetical protein Sare_1442 4 None None None 159036309 Common - dihydropteroate synthase Sare_0649 215 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 159036362 Common - ABC transporter related Sare_0705 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 159036493 Common - Ppx/GppA phosphatase Sare_0837 179 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 159039311 Common - phage/plasmid primase, P4 family Sare_3780 44 COG3378 COG3378, Predicted ATPase General function prediction only 159038886 Common - Deoxyribonuclease V Sare_3345 73 COG1515 Nfi, Deoxyinosine 3'endonuclease (endonuclease V) DNA replication, recombination, and repair 159037990 Common - Methyltransferase type 11 Sare_2394 69 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 159038407 Common - hypothetical protein Sare_2834 10 None None None 159038761 Common - NmrA family protein Sare_3216 77 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 159039662 Common - succinyl-diaminopimelate desuccinylase Sare_4134 187 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 159039772 Common - ribosomal protein S9 Sare_4253 228 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 159038028 Common - hypothetical protein Sare_2441 6 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 159037923 Common - Cytochrome P450-like protein Sare_2327 77 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159040357 Common - protein of unknown function DUF397 Sare_4869 6 None None None 159040278 Common - adenylate/guanylate cyclase with TPR repeats Sare_4787 76 COG3899 COG3899, Predicted ATPase General function prediction only 159040032 Common - response regulator receiver protein Sare_4522 218 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 159039312 Nonpathogen - hypothetical protein Sare_3781 1 None None None 159039305 Nonpathogen - hypothetical protein Sare_3774 1 None None None 159039010 Common - YbaK/prolyl-tRNA synthetase associated region Sare_3470 83 COG2606 EbsC, Uncharacterized conserved protein Function unknown 159038523 Common - short-chain dehydrogenase/reductase SDR Sare_2959 238 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 159040108 Nonpathogen - hypothetical protein Sare_4612 1 None None None 159038007 Common - short-chain dehydrogenase/reductase SDR Sare_2412 150 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159038220 Common - methyltransferase FkbM family Sare_2645 20 None None None 159037976 Nonpathogen - CsbD family protein Sare_2380 1 None None None 159035949 Nonpathogen - hypothetical protein Sare_0280 1 None None None 159037261 Common - sulphate transporter Sare_1631 162 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 159038948 Common - hypothetical protein Sare_3408 15 None None None 159038805 Common - hypothetical protein Sare_3264 4 None None None 159036978 Common - guanosine pentaphosphate synthetase I/polyribonucleotide nucleotidyltransferase Sare_1339 237 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 159038315 Common - transport system permease protein Sare_2742 189 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 159036973 Common - MATE efflux family protein Sare_1334 25 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 159036731 Common - hypothetical protein Sare_1085 2 None None None 159037572 Nonpathogen - hypothetical protein Sare_1949 1 None None None 159039597 Common - hypothetical protein Sare_4069 13 None None None 159038497 Common - protein of unknown function DUF1205 Sare_2933 13 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 159038800 Common - thioesterase superfamily protein Sare_3259 28 COG5496 COG5496, Predicted thioesterase General function prediction only 159037870 Nonpathogen - hypothetical protein Sare_2273 1 None None None 159040548 Common - single-strand binding protein Sare_5067 190 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 159038423 Common - flavoprotein Sare_2851 117 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 159039253 Nonpathogen - hypothetical protein Sare_3722 1 None None None 159037664 Common - purine or other phosphorylase family 1 Sare_2059 81 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 159037711 Common - Activator of Hsp90 ATPase 1 family protein Sare_2108 56 COG3832 COG3832, Uncharacterized conserved protein Function unknown 159038533 Common - protein of unknown function DUF397 Sare_2969 6 None None None 159039482 Nonpathogen - hypothetical protein Sare_3954 1 None None None 159039382 Nonpathogen - hypothetical protein Sare_3851 1 None None None 159036508 Common - lipolytic protein G-D-S-L family Sare_0852 13 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 159038200 Common - hypothetical protein Sare_2622 7 COG1470 COG1470, Predicted membrane protein Function unknown 159039648 Common - UvrD/REP helicase Sare_4120 228 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 159037608 Nonpathogen - hypothetical protein Sare_1988 1 None None None 159040334 Common - Alcohol dehydrogenase GroES domain protein Sare_4846 204 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 159039590 Common - peptidase S1 and S6 chymotrypsin/Hap Sare_4062 221 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 159036919 Nonpathogen - DoxX family protein Sare_1276 1 None None None 159036291 Common - quorum-sensing autoinducer 2 (AI-2), LuxS Sare_0630 54 COG1854 LuxS, LuxS protein involved in autoinducer AI2 synthesis Signal transduction mechanisms 159037569 Common - Asparaginase/glutaminase Sare_1946 113 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 159035945 Common - putative transcriptional regulator Sare_0276 7 COG2345 COG2345, Predicted transcriptional regulator Transcription 159039919 Common - dTMP kinase Sare_4404 235 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 159037765 Common - transcriptional regulator, ArsR family Sare_2163 87 COG0640 ArsR, Predicted transcriptional regulators Transcription 159038434 Common - Phosphate acetyltransferase Sare_2868 45 COG1859 KptA, RNA:NAD 2'-phosphotransferase Translation, ribosomal structure and biogenesis 159036906 Common - protein of unknown function DUF1205 Sare_1263 11 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 159039053 Common - diguanylate cyclase/phosphodiesterase Sare_3513 177 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 159035803 Common - phosphoribosyltransferase Sare_0130 75 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 159037521 Common - HAD-superfamily hydrolase, subfamily IIA Sare_1898 101 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 159038572 Common - AMP-dependent synthetase and ligase Sare_3010 196 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159037313 Common - UDP-glucose/GDP-mannose dehydrogenase Sare_1688 207 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 159037679 Common - binding-protein-dependent transport systems inner membrane component Sare_2075 8 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 159038245 Common - dehydrogenase E1 component Sare_2670 150 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 159036059 Common - binding-protein-dependent transport systems inner membrane component Sare_0392 144 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 159038644 Nonpathogen - hypothetical protein Sare_3093 2 None None None 159040180 Common - Tetratricopeptide TPR_2 repeat protein Sare_4689 39 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 159036597 Nonpathogen - hypothetical protein Sare_0944 1 None None None 159038250 Common - AMP-dependent synthetase and ligase Sare_2675 201 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159036992 Common - ornithine cyclodeaminase/mu-crystallin Sare_1353 71 COG2423 COG2423, Predicted ornithine cyclodeaminase, mu-crystallin homolog Amino acid transport and metabolism 159037799 Common - homocysteine S-methyltransferase Sare_2200 155 COG2040 MHT1, Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) Amino acid transport and metabolism 159038221 Common - putative nicotinate phosphoribosyltransferase Sare_2646 122 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 159038846 Common - SUF system FeS assembly protein, NifU family Sare_3305 107 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 159035715 Common - transcriptional regulator, XRE family Sare_0041 6 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 159038455 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Sare_2891 104 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 159035866 Common - nitrate reductase, beta subunit Sare_0193 147 COG1140 NarY, Nitrate reductase beta subunit Energy production and conversion 159039062 Common - transcriptional regulator, AsnC family Sare_3522 27 COG1522 Lrp, Transcriptional regulators Transcription 159037789 Common - hypothetical protein Sare_2189 19 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 159036652 Common - GCN5-related N-acetyltransferase Sare_1003 19 COG1243 ELP3, Histone acetyltransferase Transcription / Chromatin structure and dynamics 159038259 Common - Beta-ketoacyl synthase Sare_2684 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159038739 Common - transcriptional regulator, AraC family Sare_3194 72 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 159037452 Common - sulfotransferase Sare_1828 26 None None None 159037792 Common - extracellular solute-binding protein family 5 Sare_2193 4 COG4533 COG4533, ABC-type uncharacterized transport system, periplasmic component General function prediction only 159037654 Common - Methyltransferase type 12 Sare_2049 94 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159037528 Common - Thiamin pyrophosphokinase catalytic region Sare_1905 19 COG4825 COG4825, Uncharacterized membrane-anchored protein conserved in bacteria Function unknown 159038688 Common - major facilitator superfamily MFS_1 Sare_3142 86 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 159036835 Common - UTP-GlnB uridylyltransferase, GlnD Sare_1189 119 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 159039388 Common - GTP-binding protein Obg/CgtA Sare_3858 249 COG0536 Obg, Predicted GTPase General function prediction only 159036939 Common - helix-turn-helix domain protein Sare_1300 6 None None None 159037816 Common - putative transcriptional regulator, PucR family Sare_2218 9 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 159037733 Common - hypothetical protein Sare_2130 8 None None None 159037492 Common - nicotinamide mononucleotide transporter PnuC Sare_1869 9 COG3201 PnuC, Nicotinamide mononucleotide transporter Coenzyme metabolism 159037639 Common - tryptophan halogenase Sare_2031 134 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 159038697 Common - Beta-ketoacyl synthase Sare_3151 213 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159037415 Common - ABC transporter related Sare_1791 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 159036555 Common - hypothetical protein Sare_0900 9 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 159036595 Nonpathogen - hypothetical protein Sare_0942 5 None None None 159039804 Common - ribosomal protein L17 Sare_4285 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 159037575 Nonpathogen - hypothetical protein Sare_1952 1 COG1669 COG1669, Predicted nucleotidyltransferases General function prediction only 159035933 Common - 2-isopropylmalate synthase Sare_0263 210 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 159038732 Nonpathogen - hypothetical protein Sare_3187 1 None None None 159037123 Common - GCN5-related N-acetyltransferase Sare_1487 46 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 159036224 Common - transcriptional regulator, MerR family Sare_0557 11 COG0789 SoxR, Predicted transcriptional regulators Transcription 159036299 Common - transcriptional regulator, TetR family Sare_0638 40 COG1309 AcrR, Transcriptional regulator Transcription 159037926 Common - VioB - polyketide synthase Sare_2330 7 None None None 159037118 Common - hypothetical protein Sare_1482 12 None None None 159039304 Nonpathogen - hypothetical protein Sare_3773 1 None None None 159038138 Common - major facilitator superfamily MFS_1 Sare_2558 6 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159040072 Common - Acetaldehyde dehydrogenase Sare_4566 37 COG4569 MhpF, Acetaldehyde dehydrogenase (acetylating) Secondary metabolites biosynthesis, transport, and catabolism 159039125 Nonpathogen - hypothetical protein Sare_3587 1 None None None 159038995 Common - NADH/Ubiquinone/plastoquinone (complex I) Sare_3455 209 COG0651 HyfB, Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit Energy production and conversion / Inorganic ion transport and metabolism 159039347 Common - ABC-3 protein Sare_3816 168 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 159039544 Common - ATP synthase F0, B subunit Sare_4016 36 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 159039694 Nonpathogen - hypothetical protein Sare_4167 3 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 159038563 Common - binding-protein-dependent transport systems inner membrane component Sare_3001 148 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 159040566 Common - protein of unknown function DUF397 Sare_5086 5 None None None 159039614 Nonpathogen - hypothetical protein Sare_4086 1 COG5305 COG5305, Predicted membrane protein Function unknown 159036278 Common - Recombinase Sare_0612 42 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 159039094 Common - protein of unknown function DUF893 YccS/YhfK Sare_3554 4 COG1289 COG1289, Predicted membrane protein Function unknown 159036396 Common - UDP-glucose 4-epimerase Sare_0739 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 159037723 Nonpathogen - thiamineS protein Sare_2120 1 None None None 159037775 Common - transcriptional regulator, AraC family Sare_2175 57 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 159037611 Nonpathogen - OmpA/MotB domain protein Sare_1994 1 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 159037946 Common - protein of unknown function DUF214 Sare_2350 29 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 159039806 Common - RNA-binding S4 domain protein Sare_4287 244 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 159040131 Nonpathogen - hypothetical protein Sare_4635 10 None None None 159036335 Common - MaoC domain protein dehydratase Sare_0676 78 COG2030 MaoC, Acyl dehydratase Lipid metabolism 159038502 Nonpathogen - hypothetical protein Sare_2938 1 None None None 159039529 Common - aldehyde dehydrogenase Sare_4001 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 159038139 Common - band 7 protein Sare_2559 209 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 159039154 Nonpathogen - hypothetical protein Sare_3618 1 None None None 159036701 Common - AMP-dependent synthetase and ligase Sare_1054 184 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159040384 Nonpathogen - hypothetical protein Sare_4897 1 None None None 159035690 Common - regulator of chromosome condensation, RCC1 Sare_0016 27 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 159039637 Common - bifunctional deaminase-reductase domain protein Sare_4109 37 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 159037302 Nonpathogen - hypothetical protein Sare_1676 1 None None None 159038493 Nonpathogen - hypothetical protein Sare_2929 3 None None None 159040042 Common - protein serine/threonine phosphatase Sare_4532 123 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 159035927 Common - binding-protein-dependent transport systems inner membrane component Sare_0257 210 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 159035938 Common - 5'-Nucleotidase domain protein Sare_0268 134 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 159036114 Common - ATP-dependent DNA helicase, RecQ family Sare_0447 180 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 159037848 Common - DEAD/DEAH box helicase domain protein Sare_2250 230 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 159040447 Common - Peptidoglycan-binding LysM Sare_4963 8 None None None 159039895 Common - parallel beta-helix repeat Sare_4376 19 None None None 159038187 Common - major facilitator superfamily MFS_1 Sare_2609 198 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159040125 Nonpathogen - hypothetical protein Sare_4629 3 None None None 159035838 Common - Radical SAM domain protein Sare_0165 61 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 159035699 Common - Fe-S metabolism associated SufE Sare_0025 13 COG2166 COG2166, SufE protein probably involved in Fe-S center assembly General function prediction only 159037249 Common - short-chain dehydrogenase/reductase SDR Sare_1619 225 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 159037159 Common - coagulation factor 5/8 type domain protein Sare_1525 21 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 159036675 Common - MmgE/PrpD family protein Sare_1027 57 COG2079 PrpD, Uncharacterized protein involved in propionate catabolism General function prediction only 159036590 Nonpathogen - hypothetical protein Sare_0937 3 None None None 159035847 Common - ABC-type branched-chain amino acid transport systems periplasmic component-like protein Sare_0174 64 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 159038684 Common - nitrate reductase, alpha subunit Sare_3138 133 COG5013 NarG, Nitrate reductase alpha subunit Energy production and conversion 159036719 Common - regulator of chromosome condensation RCC1 Sare_1072 33 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 159040290 Nonpathogen - hypothetical protein Sare_4800 2 None None None 159040049 Nonpathogen - hypothetical protein Sare_4539 1 None None None 159038444 Common - Rieske (2Fe-2S) domain protein Sare_2880 68 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 159037991 Common - protein of unknown function DUF6 transmembrane Sare_2395 56 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 159038304 Common - DNA binding domain, excisionase family Sare_2731 22 COG3585 MopI, Molybdopterin-binding protein Coenzyme metabolism 159038868 Common - protein of unknown function UPF0052 and CofD Sare_3327 87 COG0391 COG0391, Uncharacterized conserved protein Function unknown 159037670 Common - transcriptional regulator, AraC family Sare_2066 164 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 159037998 Common - transport system permease protein Sare_2402 36 COG4605 CeuC, ABC-type enterochelin transport system, permease component Inorganic ion transport and metabolism 159040013 Nonpathogen - hypothetical protein Sare_4503 1 None None None 159038477 Common - secreted protein Sare_2913 16 COG3868 COG3868, Uncharacterized conserved protein Function unknown 159037242 Common - 2-nitropropane dioxygenase NPD Sare_1611 13 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 159036238 Common - Saccharopine dehydrogenase Sare_0572 19 COG1748 LYS9, Saccharopine dehydrogenase and related proteins Amino acid transport and metabolism 159040398 Common - polymorphic outer membrane protein Sare_4912 19 None None None 159037410 Common - aminotransferase class V Sare_1785 32 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 159037355 Nonpathogen - hypothetical protein Sare_1730 1 None None None 159040423 Common - alpha/beta hydrolase fold Sare_4939 19 COG2267 PldB, Lysophospholipase Lipid metabolism 159038317 Common - ABC transporter related Sare_2744 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 159038911 Nonpathogen - hypothetical protein Sare_3371 10 None None None 159040187 Common - Methyltransferase type 11 Sare_4696 119 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 159037883 Nonpathogen - hypothetical protein Sare_2287 1 None None None 159036284 Common - ABC transporter related Sare_0621 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159038587 Nonpathogen - hypothetical protein Sare_3027 1 None None None 159037965 Nonpathogen - hypothetical protein Sare_2369 1 None None None 159038415 Nonpathogen - hypothetical protein Sare_2842 1 None None None 159036081 Nonpathogen - Protein of unknown function DUF1713 Sare_0414 1 None None None 159036147 Common - hypothetical protein Sare_0480 11 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 159036924 Common - hypothetical protein Sare_1281 4 None None None 159036964 Common - NusA antitermination factor Sare_1325 220 COG0195 NusA, Transcription elongation factor Transcription 159038514 Common - hypothetical protein Sare_2950 2 COG3239 DesA, Fatty acid desaturase Lipid metabolism 159036368 Nonpathogen - hypothetical protein Sare_0711 4 COG0839 NuoJ, NADH:ubiquinone oxidoreductase subunit 6 (chain J) Energy production and conversion 159040026 Common - ResB family protein Sare_4516 37 COG1333 ResB, ResB protein required for cytochrome c biosynthesis Posttranslational modification, protein turnover, chaperones 159037630 Common - glycosyltransferase, MGT family Sare_2021 37 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 159038635 Common - protein of unknown function DUF262 Sare_3084 41 COG3472 COG3472, Uncharacterized conserved protein Function unknown 159037842 Common - peptidylprolyl isomerase FKBP-type Sare_2244 122 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 159036786 Common - hypothetical protein Sare_1140 12 None None None 159036006 Nonpathogen - hypothetical protein Sare_0338 1 None None None 159039843 Common - DNA-directed RNA polymerase, beta' subunit Sare_4324 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 159035747 Nonpathogen - FAD dependent oxidoreductase Sare_0074 16 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 159036127 Common - Pyridoxal-dependent decarboxylase Sare_0460 61 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 159036628 Common - hypothetical protein Sare_0978 11 None None None 159036346 Nonpathogen - hypothetical protein Sare_0687 1 None None None 159039517 Common - methylmalonyl-CoA mutase, large subunit Sare_3989 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 159036665 Common - hypothetical protein Sare_1016 12 COG5650 COG5650, Predicted integral membrane protein Function unknown 159037833 Common - metallophosphoesterase Sare_2235 12 COG1409 Icc, Predicted phosphohydrolases General function prediction only 159037163 Common - GAF sensor signal transduction histidine kinase Sare_1529 132 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 159039424 Common - Amidase Sare_3895 209 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 159040155 Common - protein of unknown function DUF1470 Sare_4664 10 COG5516 COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding General function prediction only 159037864 Common - Integral membrane protein TerC Sare_2267 89 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 159040197 Common - formylmethionine deformylase Sare_4706 208 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 159040138 Common - MOSC domain containing protein Sare_4643 78 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 159037800 Nonpathogen - hypothetical protein Sare_2201 1 None None None 159037363 Nonpathogen - hypothetical protein Sare_1738 1 None None None 159038716 Common - putative transcriptional regulator, PaaX family Sare_3171 10 COG3327 PaaX, Phenylacetic acid-responsive transcriptional repressor Transcription 159039232 Nonpathogen - hypothetical protein Sare_3701 1 None None None 159039783 Common - protein of unknown function DUF742 Sare_4264 8 None None None 159035732 Common - protein of unknown function UPF0233 Sare_0058 17 None None None 159037188 Common - two component transcriptional regulator, winged helix family Sare_1554 217 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159036382 Common - hydrolase, TatD family Sare_0725 234 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 159037063 Common - peptidase S8 and S53 subtilisin kexin sedolisin Sare_1426 154 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 159037712 Common - transcriptional regulator, ArsR family Sare_2109 85 COG0640 ArsR, Predicted transcriptional regulators Transcription 159039816 Common - ribosomal protein L30 Sare_4297 136 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 159036756 Common - diguanylate cyclase/phosphodiesterase Sare_1110 173 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 159039826 Common - ribosomal protein L29 Sare_4307 73 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 159037275 Common - LamG domain protein jellyroll fold domain protein Sare_1645 8 None None None 159035972 Nonpathogen - hypothetical protein Sare_0304 1 None None None 159038541 Common - regulator of chromosome condensation, RCC1 Sare_2978 29 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 159039191 Nonpathogen - hypothetical protein Sare_3655 3 None None None 159035881 Common - hypothetical protein Sare_0208 6 None None None 159039441 Common - major facilitator superfamily MFS_1 Sare_3912 51 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159036688 Common - GCN5-related N-acetyltransferase Sare_1041 91 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 159037010 Common - Lysine exporter protein (LYSE/YGGA) Sare_1371 60 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 159038603 Nonpathogen - hypothetical protein Sare_3046 1 None None None 159036932 Common - protein of unknown function DUF742 Sare_1291 9 None None None 159036694 Common - Saccharopine dehydrogenase Sare_1047 7 COG1748 LYS9, Saccharopine dehydrogenase and related proteins Amino acid transport and metabolism 159040391 Common - hypothetical protein Sare_4904 5 None None None 159039440 Common - MscS Mechanosensitive ion channel Sare_3911 209 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 159039326 Common - amine oxidase Sare_3795 20 COG1232 HemY, Protoporphyrinogen oxidase Coenzyme metabolism 159039494 Common - TspO and MBR like protein Sare_3966 65 COG3476 COG3476, Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) Signal transduction mechanisms 159038543 Common - phosphoribulokinase / uridine kinase family Sare_2980 11 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 159036846 Common - signal peptidase I Sare_1200 172 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 159040492 Common - Na+/solute symporter Sare_5011 122 COG4147 DhlC, Predicted symporter General function prediction only 159037303 Common - hypothetical protein Sare_1677 5 None None None 159036180 Common - major facilitator superfamily MFS_1 Sare_0513 47 None None None 159037557 Nonpathogen - hypothetical protein Sare_1934 1 None None None 159038459 Common - protein of unknown function DUF81 Sare_2895 35 COG0730 COG0730, Predicted permeases General function prediction only 159039082 Common - aldo/keto reductase Sare_3542 198 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 159039299 Nonpathogen - hypothetical protein Sare_3768 1 None None None 159036133 Common - RarD protein, DMT superfamily transporter Sare_0466 91 COG2962 RarD, Predicted permeases General function prediction only 159039187 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Sare_3651 84 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 159040486 Common - DNA-(apurinic or apyrimidinic site) lyase Sare_5005 179 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 159037903 Common - hypothetical protein Sare_2307 7 COG1412 COG1412, Uncharacterized proteins of PilT N-term./Vapc superfamily General function prediction only 159036273 Nonpathogen - hypothetical protein Sare_0607 1 None None None 159037212 Nonpathogen - DNA binding domain, excisionase family Sare_1579 1 None None None 159037174 Common - Activator of Hsp90 ATPase 1 family protein Sare_1540 16 COG3832 COG3832, Uncharacterized conserved protein Function unknown 159038298 Common - putative esterase Sare_2723 100 COG0627 COG0627, Predicted esterase General function prediction only 159037234 Common - two component transcriptional regulator, LuxR family Sare_1603 204 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159036245 Common - beta-ribofuranosylaminobenzene 5'-phosphate synthase family Sare_0579 29 COG1907 COG1907, Predicted archaeal sugar kinases General function prediction only 159039248 Nonpathogen - hypothetical protein Sare_3717 1 None None None 159039777 Common - molybdopterin oxidoreductase Sare_4258 184 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 159037513 Common - DNA-3-methyladenine glycosylase Sare_1890 79 COG2094 Mpg, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 159039378 Common - DNA internalization-related competence protein ComEC/Rec2 Sare_3847 86 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 159039151 Common - glutamyl-tRNA synthetase Sare_3615 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 159036546 Common - hypothetical protein Sare_0891 18 None None None 159036040 Common - Domain of unknown function DUF1794 Sare_0373 16 None None None 159038831 Common - hypothetical protein Sare_3290 7 None None None 159036500 Nonpathogen - hypothetical protein Sare_0844 1 None None None 159036516 Common - asparagine synthase (glutamine-hydrolyzing) Sare_0860 159 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 159036961 Common - hypothetical protein Sare_1322 4 None None None 159036187 Common - ABC transporter related Sare_0520 245 COG1134 TagH, ABC-type polysaccharide/polyol phosphate transport system, ATPase component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 159038226 Nonpathogen - hypothetical protein Sare_2651 3 None None None 159040575 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sare_5095 152 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159040440 Common - monooxygenase, FAD-binding Sare_4956 23 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 159037070 Common - hypothetical protein Sare_1433 6 None None None 159038877 Common - ATP-dependent DNA helicase RecQ Sare_3336 212 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 159037628 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Sare_2018 162 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 159036507 Common - acetyl-CoA acetyltransferase Sare_0851 186 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 159037053 Common - NADH:flavin oxidoreductase/NADH oxidase Sare_1415 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 159039534 Common - 3-hydroxybutyryl-CoA dehydrogenase Sare_4006 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 159037336 Common - transcriptional regulator, TetR family Sare_1711 14 COG1309 AcrR, Transcriptional regulator Transcription 159035916 Common - hypothetical protein Sare_0244 14 None None None 159037697 Common - phosphopantetheine-binding Sare_2094 31 None None None 159037782 Common - hypothetical protein Sare_2182 5 None None None 159036064 Common - short-chain dehydrogenase/reductase SDR Sare_0397 232 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 159036310 Common - hypothetical protein Sare_0650 5 None None None 159038927 Common - ABC transporter related Sare_3387 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159036120 Common - hypothetical protein Sare_0453 7 None None None 159039577 Common - short-chain dehydrogenase/reductase SDR Sare_4049 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159039835 Common - ribosomal protein S10 Sare_4316 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 159038946 Common - ABC transporter related Sare_3406 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 159036798 Common - NUDIX hydrolase Sare_1152 37 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 159036822 Common - fatty acid synthesis plsX protein Sare_1176 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 159036873 Nonpathogen - hypothetical protein Sare_1229 2 None None None 159037374 Common - phosphoheptose isomerase Sare_1749 121 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 159036888 Common - cytochrome P450 Sare_1245 79 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159036830 Common - hypothetical protein Sare_1184 21 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 159038849 Common - Rieske (2Fe-2S) domain protein Sare_3308 90 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 159038625 Common - glycosyl hydrolase, BNR repeat-containing protein Sare_3069 30 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 159035714 Nonpathogen - hypothetical protein Sare_0040 1 None None None 159037880 Common - citrate synthase I Sare_2284 194 COG0372 GltA, Citrate synthase Energy production and conversion 159040476 Common - Rhomboid family protein Sare_4995 115 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 159037082 Common - hypothetical protein Sare_1445 11 None None None 159039982 Common - phenylacetate-CoA oxygenase, PaaI subunit Sare_4470 42 COG3396 COG3396, Uncharacterized conserved protein Function unknown 159039069 Common - response regulator receiver protein Sare_3529 11 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159039704 Common - binding-protein-dependent transport systems inner membrane component Sare_4177 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 159037809 Nonpathogen - hypothetical protein Sare_2210 1 None None None 159039004 Common - Methyltransferase type 11 Sare_3464 11 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 159039516 Common - Thioredoxin domain Sare_3988 231 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 159037621 Nonpathogen - hypothetical protein Sare_2007 6 None None None 159036469 Nonpathogen - transcriptional regulator, XRE family Sare_0812 1 COG1476 COG1476, Predicted transcriptional regulators Transcription 159040533 Common - hypothetical protein Sare_5052 16 COG4178 COG4178, ABC-type uncharacterized transport system, permease and ATPase components General function prediction only 159036761 Common - metallophosphoesterase Sare_1115 5 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 159037533 Common - hypothetical protein Sare_1910 4 None None None 159037471 Common - carbamoyl-phosphate synthase, small subunit Sare_1848 232 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 159035753 Nonpathogen - hypothetical protein Sare_0080 1 None None None 159039413 Nonpathogen - hypothetical protein Sare_3884 1 None None None 159037893 Common - response regulator receiver and ANTAR domain protein Sare_2297 12 COG3707 AmiR, Response regulator with putative antiterminator output domain Signal transduction mechanisms 159040332 Common - phosphoenolpyruvate-protein phosphotransferase Sare_4844 209 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 159040588 Common - 60 kDa inner membrane insertion protein Sare_5108 212 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 159038424 Common - Restriction endonuclease S subunits-like protein Sare_2852 40 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 159038960 Common - Imidazoleglycerol-phosphate dehydratase Sare_3420 212 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 159036813 Common - ribosomal protein L28 Sare_1167 70 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 159040144 Common - putative RNA polymerase, sigma-24 subunit, ECF subfamily Sare_4650 47 COG4941 COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain Transcription 159038194 Nonpathogen - hypothetical protein Sare_2616 1 None None None 159038141 Nonpathogen - hypothetical protein Sare_2561 1 None None None 159038907 Nonpathogen - hypothetical protein Sare_3367 1 None None None 159035773 Nonpathogen - hypothetical protein Sare_0100 1 None None None 159039502 Common - Undecaprenyl-phosphate galactose phosphotransferase Sare_3974 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 159036753 Common - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Sare_1107 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 159038594 Common - alpha/beta hydrolase fold Sare_3034 13 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159038551 Common - Methyltransferase type 11 Sare_2989 62 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159037122 Common - DNA polymerase LigD polymerase domain Sare_1486 66 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 159036095 Common - Uroporphyrinogen III synthase HEM4 Sare_0428 204 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 159036101 Common - Tetratricopeptide TPR_4 Sare_0434 29 COG3903 COG3903, Predicted ATPase General function prediction only 159039147 Common - transcriptional regulator, MarR family Sare_3611 103 COG1846 MarR, Transcriptional regulators Transcription 159040590 Nonpathogen - ribonuclease P protein component Sare_5110 2 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 159038061 Nonpathogen - hypothetical protein Sare_2480 1 None None None 159038109 Common - hypothetical protein Sare_2528 9 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 159040216 Common - binding-protein-dependent transport systems inner membrane component Sare_4725 65 COG1174 OpuBB, ABC-type proline/glycine betaine transport systems, permease component Amino acid transport and metabolism 159039462 Nonpathogen - hypothetical protein Sare_3934 6 None None None 159037296 Nonpathogen - hypothetical protein Sare_1670 1 None None None 159038387 Common - acyl-CoA dehydrogenase domain protein Sare_2814 150 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159039392 Common - hypothetical protein Sare_3862 28 COG5011 COG5011, Uncharacterized protein conserved in bacteria Function unknown 159035955 Common - N-acetylglucosamine-6-phosphate deacetylase Sare_0286 118 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 159040511 Common - hypothetical protein Sare_5030 20 COG3603 COG3603, Uncharacterized conserved protein Function unknown 159038114 Nonpathogen - hypothetical protein Sare_2533 1 None None None 159038734 Common - major facilitator superfamily MFS_1 Sare_3189 54 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 159037225 Nonpathogen - hypothetical protein Sare_1594 1 None None None 159037219 Nonpathogen - hypothetical protein Sare_1587 1 None None None 159035682 Common - DNA gyrase, A subunit Sare_0008 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 159035903 Common - CMP/dCMP deaminase zinc-binding Sare_0230 194 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 159037502 Common - phenylalanyl-tRNA synthetase, alpha subunit Sare_1879 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 159039435 Common - tryptophan 23-dioxygenase Sare_3906 42 COG3483 TDO2, Tryptophan 2,3-dioxygenase (vermilion) Amino acid transport and metabolism 159039520 Nonpathogen - hypothetical protein Sare_3992 1 None None None 159039286 Nonpathogen - Peptidoglycan-binding domain 1 protein Sare_3755 3 COG2989 COG2989, Uncharacterized protein conserved in bacteria Function unknown 159035707 Common - Propionyl-CoA carboxylase Sare_0033 161 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 159036257 Common - flavin reductase domain protein FMN-binding Sare_0591 116 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 159039569 Common - transcriptional regulator, TetR family Sare_4041 60 COG1309 AcrR, Transcriptional regulator Transcription 159039870 Common - DNA polymerase LigD polymerase domain Sare_4351 66 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 159040238 Common - transcriptional regulator, AraC family Sare_4747 117 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 159040100 Common - short-chain dehydrogenase/reductase SDR Sare_4604 237 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 159038856 Common - protoheme IX farnesyltransferase Sare_3315 170 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 159036052 Nonpathogen - GCN5-related N-acetyltransferase Sare_0385 4 COG3153 COG3153, Predicted acetyltransferase General function prediction only 159037203 Nonpathogen - hypothetical protein Sare_1569 1 None None None 159039937 Common - hypothetical protein Sare_4422 11 COG4963 CpaE, Flp pilus assembly protein, ATPase CpaE Intracellular trafficking and secretion 159037826 Common - protein of unknown function DUF690 Sare_2228 8 None None None 159036474 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Sare_0817 244 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 159035898 Common - protein of unknown function DUF6 transmembrane Sare_0225 46 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 159039760 Common - putative metalloendopeptidase, glycoprotease family Sare_4241 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 159038591 Nonpathogen - hypothetical protein Sare_3031 1 None None None 159040165 Common - fumarate lyase Sare_4674 236 COG0114 FumC, Fumarase Energy production and conversion 159040174 Common - Pyrrolo-quinoline quinone Sare_4683 9 COG1520 COG1520, FOG: WD40-like repeat Function unknown 159036213 Common - glucose-methanol-choline oxidoreductase Sare_0546 58 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 159038352 Common - Bile acid:sodium symporter Sare_2779 79 COG0385 COG0385, Predicted Na+-dependent transporter General function prediction only 159037019 Common - peptidase M23B Sare_1381 189 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 159039250 Nonpathogen - hypothetical protein Sare_3719 1 None None None 159039012 Common - GCN5-related N-acetyltransferase Sare_3472 11 COG4195 COG4195, Phage-related replication protein General function prediction only 159038291 Common - major facilitator superfamily MFS_1 Sare_2716 204 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159038813 Nonpathogen - Lantibiotic dehydratase domain protein Sare_3272 4 None None None 159038677 Common - protein of unknown function DUF328 Sare_3131 86 COG3022 COG3022, Uncharacterized protein conserved in bacteria Function unknown 159039912 Common - hypothetical protein Sare_4397 18 None None None 159035836 Common - amidophosphoribosyltransferase Sare_0163 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 159036506 Nonpathogen - hypothetical protein Sare_0850 1 None None None 159040262 Nonpathogen - hypothetical protein Sare_4771 1 None None None 159039688 Common - peptidase S51 dipeptidase E Sare_4161 15 COG3340 PepE, Peptidase E Amino acid transport and metabolism 159037377 Common - glycosyl transferase family 9 Sare_1752 73 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 159036856 Nonpathogen - hypothetical protein Sare_1211 1 None None None 159040464 Common - Quinone oxidoreductase putative PIG3 Sare_4983 191 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 159038480 Common - acyltransferase 3 Sare_2916 3 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 159039600 Common - phosphate acetyltransferase Sare_4072 164 COG0280 Pta, Phosphotransacetylase Energy production and conversion 159036740 Common - PfkB domain protein Sare_1094 149 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 159039967 Common - NADH-quinone oxidoreductase, chain I Sare_4455 191 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 159038431 Common - AMP-dependent synthetase and ligase Sare_2861 224 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159038884 Common - protein of unknown function DUF312 Sare_3343 5 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 159036584 Common - hypothetical protein Sare_0931 2 COG4842 COG4842, Uncharacterized protein conserved in bacteria Function unknown 159038880 Common - excinuclease ABC, A subunit Sare_3339 237 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 159038889 Common - peptidase S1 and S6 chymotrypsin/Hap Sare_3349 19 COG5640 COG5640, Secreted trypsin-like serine protease Posttranslational modification, protein turnover, chaperones 159036030 Common - amino acid adenylation domain Sare_0363 215 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159039188 Common - transcriptional regulator, XRE family Sare_3652 104 COG1396 HipB, Predicted transcriptional regulators Transcription 159040351 Common - coagulation factor 5/8 type domain protein Sare_4863 8 None None None 159037504 Common - N-acetyl-gamma-glutamyl-phosphate reductase Sare_1881 211 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 159038125 Common - FAD dependent oxidoreductase Sare_2545 63 COG2072 TrkA, Predicted flavoprotein involved in K+ transport Inorganic ion transport and metabolism 159039116 Common - hypothetical protein Sare_3578 12 None None None 159036625 Common - hypothetical protein Sare_0975 2 None None None 159040000 Common - hypothetical protein Sare_4490 6 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159038754 Common - transcriptional regulator, RpiR family Sare_3209 113 COG1737 RpiR, Transcriptional regulators Transcription 159036567 Common - excision promoter, Xis Sare_0912 7 COG3311 AlpA, Predicted transcriptional regulator Transcription 159040069 Common - MbtH domain protein Sare_4563 37 COG3251 COG3251, Uncharacterized protein conserved in bacteria Function unknown 159037314 Common - glycosyl transferase group 1 Sare_1689 92 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159039985 Common - hypothetical protein Sare_4473 8 None None None 159036921 Common - FAD dependent oxidoreductase Sare_1278 46 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159038103 Common - protein of unknown function DUF881 Sare_2522 16 COG3879 COG3879, Uncharacterized protein conserved in bacteria Function unknown 159039314 Nonpathogen - hypothetical protein Sare_3783 1 None None None 159038029 Nonpathogen - hypothetical protein Sare_2442 1 None None None 159038812 Nonpathogen - Lantibiotic dehydratase domain protein Sare_3271 4 None None None 159039775 Nonpathogen - hypothetical protein Sare_4256 1 None None None 159036771 Common - ketol-acid reductoisomerase Sare_1125 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 159038091 Common - putative transcriptional regulator, PaaX family Sare_2510 10 COG3327 PaaX, Phenylacetic acid-responsive transcriptional repressor Transcription 159036743 Nonpathogen - hypothetical protein Sare_1097 1 None None None 159037015 Nonpathogen - hypothetical protein Sare_1377 1 None None None 159038481 Common - putative RNA polymerase, sigma-24 subunit, ECF subfamily Sare_2917 41 COG4941 COG4941, Predicted RNA polymerase sigma factor containing a TPR repeat domain Transcription 159039595 Common - hypothetical protein Sare_4067 7 None None None 159040361 Common - transcriptional regulator, MerR family Sare_4873 108 COG0789 SoxR, Predicted transcriptional regulators Transcription 159037570 Nonpathogen - transcriptional regulator, XRE family Sare_1947 1 COG1396 HipB, Predicted transcriptional regulators Transcription 159040356 Common - plasmid maintenance system antidote protein, XRE family Sare_4868 6 COG3093 VapI, Plasmid maintenance system antidote protein General function prediction only 159036129 Common - Alcohol dehydrogenase GroES domain protein Sare_0462 59 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 159037563 Common - hypothetical protein Sare_1940 2 None None None 159038463 Common - protein of unknown function DUF664 Sare_2899 12 COG2318 DinB, Uncharacterized protein conserved in bacteria Function unknown 159037239 Common - protein of unknown function DUF805 Sare_1608 38 COG3152 COG3152, Predicted membrane protein Function unknown 159038979 Common - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Sare_3439 207 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 159036908 Common - aminotransferase class-III Sare_1265 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 159038409 Common - AMP-dependent synthetase and ligase Sare_2836 214 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159036565 Common - preprotein translocase, SecA subunit Sare_0910 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 159039664 Common - peptidase S8 and S53 subtilisin kexin sedolisin Sare_4136 94 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 159039864 Nonpathogen - hypothetical protein Sare_4345 1 None None None 159037942 Nonpathogen - hypothetical protein Sare_2346 1 None None None 159038658 Common - ATPase associated with various cellular activities AAA_3 Sare_3112 172 COG0714 COG0714, MoxR-like ATPases General function prediction only 159037101 Common - protein of unknown function DUF1470 Sare_1464 25 COG5516 COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding General function prediction only 159036415 Common - Methyltransferase type 11 Sare_0758 49 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159040060 Common - methyltransferase FkbM family Sare_4554 18 COG2242 CobL, Precorrin-6B methylase 2 Coenzyme metabolism 159039488 Common - transcriptional regulator, RpiR family Sare_3960 159 COG1737 RpiR, Transcriptional regulators Transcription 159040512 Nonpathogen - hypothetical protein Sare_5031 1 None None None 159037447 Common - hypothetical protein Sare_1823 11 None None None 159037093 Common - hypothetical protein Sare_1456 7 None None None 159037232 Common - ABC transporter related Sare_1601 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159037687 Common - Arsenical pump membrane protein Sare_2083 24 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 159039652 Common - protein of unknown function DUF397 Sare_4124 6 None None None 159039089 Common - Leucyl aminopeptidase Sare_3549 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 159040103 Common - glycerol kinase Sare_4607 180 COG0554 GlpK, Glycerol kinase Energy production and conversion 159036026 Common - Pyridoxal-5'-phosphate-dependent protein beta subunit Sare_0358 188 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 159036246 Common - adenylosuccinate lyase Sare_0580 171 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 159036898 Common - Glutamine--scyllo-inositol transaminase Sare_1255 192 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 159039355 Common - 6-phosphogluconate dehydrogenase, decarboxylating Sare_3824 184 COG0362 Gnd, 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 159038938 Nonpathogen - hypothetical protein Sare_3398 1 None None None 159037307 Common - ABC-2 type transporter Sare_1681 94 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 159039882 Nonpathogen - heat shock protein Hsp20 Sare_4363 1 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 159039550 Common - protein tyrosine phosphatase Sare_4022 48 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 159036370 Common - NADH dehydrogenase (quinone) Sare_0713 183 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 159040117 Common - hybrid cluster protein Sare_4621 74 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 159040035 Nonpathogen - hypothetical protein Sare_4525 1 None None None 159038666 Common - MMPL domain protein Sare_3120 43 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 159040084 Common - ATPase, P-type (transporting), HAD superfamily, subfamily IC Sare_4579 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 159039541 Common - ATP synthase F1, gamma subunit Sare_4013 207 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 159039609 Common - transcription factor WhiB Sare_4081 19 None None None 159039683 Common - methionine aminopeptidase, type I Sare_4155 247 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 159037347 Common - protein of unknown function DUF75 Sare_1722 20 COG1938 COG1938, Archaeal enzymes of ATP-grasp superfamily General function prediction only 159037522 Common - hypothetical protein Sare_1899 6 None None None 159039050 Common - histidine kinase Sare_3510 131 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 159038772 Common - Roadblock/LC7 family protein Sare_3227 10 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 159038054 Nonpathogen - hypothetical protein Sare_2472 1 None None None 159035744 Common - cyclic nucleotide-binding protein Sare_0070 122 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 159038651 Nonpathogen - hypothetical protein Sare_3102 2 None None None 159035879 Common - hypothetical protein Sare_0206 4 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 159038825 Common - Xaa-Pro aminopeptidase Sare_3284 198 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 159038301 Common - asparagine synthase (glutamine-hydrolyzing) Sare_2728 142 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 159038448 Common - fumarate reductase/succinate dehydrogenase flavoprotein domain protein Sare_2884 60 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 159037684 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Sare_2080 184 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 159036100 Common - putative regulatory protein, FmdB family Sare_0433 6 None None None 159036733 Common - protein of unknown function DUF72 Sare_1087 94 COG1801 COG1801, Uncharacterized conserved protein Function unknown 159039850 Common - preprotein translocase, SecE subunit Sare_4331 36 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 159036517 Common - peptide methionine sulfoxide reductase Sare_0861 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 159038329 Common - integral membrane protein Sare_2756 5 None None None 159035679 Common - protein of unknown function DUF721 Sare_0005 21 COG5512 COG5512, Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives General function prediction only 159037975 Common - Phosphoglycerate mutase Sare_2379 139 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 159036312 Common - DNA-3-methyladenine glycosylase I Sare_0652 132 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 159039209 Nonpathogen - hypothetical protein Sare_3677 1 None None None 159039780 Common - nitrite reductase (NAD(P)H), small subunit Sare_4261 45 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 159037372 Common - hypothetical protein Sare_1747 15 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159039575 Common - hypothetical protein Sare_4047 2 None None None 159040007 Nonpathogen - hypothetical protein Sare_4497 1 None None None 159036375 Common - amino acid adenylation domain Sare_0718 201 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159036175 Common - 2'-5' RNA ligase Sare_0508 11 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 159039628 Common - GTPase EngC Sare_4100 162 COG1162 COG1162, Predicted GTPases General function prediction only 159035725 Common - Peptidoglycan glycosyltransferase Sare_0051 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 159037587 Common - Acetamidase/Formamidase Sare_1964 64 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 159038931 Common - glutamate synthase, NADH/NADPH, small subunit Sare_3391 185 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 159039023 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Sare_3483 73 COG3200 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 159038247 Common - Phytanoyl-CoA dioxygenase Sare_2672 13 COG5285 COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin Secondary metabolites biosynthesis, transport, and catabolism 159039273 Nonpathogen - helix-turn-helix domain protein Sare_3742 1 None None None 159037240 Common - hypothetical protein Sare_1609 22 None None None 159039865 Nonpathogen - hypothetical protein Sare_4346 1 None None None 159039607 Nonpathogen - hypothetical protein Sare_4079 1 None None None 159036453 Nonpathogen - hypothetical protein Sare_0796 1 None None None 159037585 Common - transcriptional regulator, XRE family Sare_1962 7 COG1709 COG1709, Predicted transcriptional regulator Transcription 159035998 Common - phosphate binding protein Sare_0330 143 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 159039064 Common - Cytochrome b/b6 domain Sare_3524 143 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 159037247 Common - Polymorphic membrane protein Chlamydia Sare_1617 38 None None None 159038002 Common - amino acid adenylation domain Sare_2407 228 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159038098 Common - transcriptional regulator, MerR family Sare_2517 20 COG0789 SoxR, Predicted transcriptional regulators Transcription 159037041 Common - tRNA delta(2)-isopentenylpyrophosphate transferase Sare_1403 212 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 159039165 Common - alpha/beta hydrolase fold Sare_3629 66 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159038264 Common - acetyl-CoA carboxylase, carboxyl transferase, beta subunit Sare_2689 219 COG0825 AccA, Acetyl-CoA carboxylase alpha subunit Lipid metabolism 159039218 Nonpathogen - hypothetical protein Sare_3687 1 None None None 159038009 Common - hypothetical protein Sare_2414 14 None None None 159039500 Common - xylulokinase Sare_3972 98 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 159040528 Common - thiamineS protein Sare_5047 5 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 159038404 Common - luciferase family protein Sare_2831 51 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 159039075 Common - PfkB domain protein Sare_3535 120 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 159040208 Common - aspartate 1-decarboxylase Sare_4717 130 COG0853 PanD, Aspartate 1-decarboxylase Coenzyme metabolism 159038528 Common - major facilitator superfamily MFS_1 Sare_2964 80 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159039838 Common - ribosomal protein S7 Sare_4319 241 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 159037148 Nonpathogen - hypothetical protein Sare_1514 1 None None None 159037958 Common - 20S proteasome A and B subunits Sare_2362 19 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 159038665 Nonpathogen - phosphoesterase PA-phosphatase related Sare_3119 1 None None None 159036959 Common - protein of unknown function DUF125 transmembrane Sare_1320 85 COG1814 COG1814, Uncharacterized membrane protein Function unknown 159036721 Nonpathogen - hypothetical protein Sare_1075 2 None None None 159035791 Common - sodium/hydrogen exchanger Sare_0118 29 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 159040507 Common - hypothetical protein Sare_5026 8 None None None 159038606 Nonpathogen - hypothetical protein Sare_3049 1 None None None 159039201 Nonpathogen - hypothetical protein Sare_3667 2 None None None 159037321 Nonpathogen - hypothetical protein Sare_1696 1 None None None 159037552 Nonpathogen - cell divisionFtsK/SpoIIIE Sare_1929 5 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 159036410 Common - inner-membrane translocator Sare_0753 113 COG4603 COG4603, ABC-type uncharacterized transport system, permease component General function prediction only 159040210 Common - hypothetical protein Sare_4719 41 COG5495 COG5495, Uncharacterized conserved protein Function unknown 159040307 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Sare_4819 86 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 159040040 Nonpathogen - hypothetical protein Sare_4530 1 None None None 159039859 Nonpathogen - hypothetical protein Sare_4340 1 None None None 159037930 Nonpathogen - hypothetical protein Sare_2334 1 None None None 159038958 Common - imidazole glycerol phosphate synthase, glutamine amidotransferase subunit Sare_3418 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 159039722 Common - succinyl-CoA synthetase, beta subunit Sare_4203 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 159036691 Common - Methionine--tRNA ligase Sare_1044 242 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159038019 Nonpathogen - hypothetical protein Sare_2426 1 None None None 159036646 Common - imidazolonepropionase Sare_0997 100 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 159039893 Common - polymorphic outer membrane protein Sare_4374 12 None None None 159040373 Nonpathogen - hypothetical protein Sare_4886 1 None None None 159036343 Common - ferric uptake regulator, Fur family Sare_0684 182 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 159037917 Common - hypothetical protein Sare_2321 18 None None None 159038272 Common - Camphor resistance CrcB protein Sare_2697 47 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 159037422 Common - crossover junction endodeoxyribonuclease RuvC Sare_1798 188 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 159037433 Common - Histidine--tRNA ligase Sare_1809 240 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159038215 Nonpathogen - Parallel beta-helix repeat Sare_2638 3 None None None 159039626 Common - protein of unknown function DUF159 Sare_4098 104 COG2135 COG2135, Uncharacterized conserved protein Function unknown 159036696 Common - acyl-CoA dehydrogenase domain protein Sare_1049 145 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159038115 Nonpathogen - hypothetical protein Sare_2534 1 None None None 159036337 Common - tRNA/rRNA methyltransferase (SpoU) Sare_0678 60 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 159036631 Common - monooxygenase FAD-binding Sare_0982 72 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 159040275 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Sare_4784 122 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 159039957 Common - putative transmembrane anti-sigma factor Sare_4445 8 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 159036050 Common - hypothetical protein Sare_0383 25 COG4982 COG4982, 3-oxoacyl- acyl-carrier protein 159038793 Common - short-chain dehydrogenase/reductase SDR Sare_3251 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159037001 Common - Ribosyldihydronicotinamide dehydrogenase (quinone) Sare_1362 97 COG2249 MdaB, Putative NADPH-quinone reductase (modulator of drug activity B) General function prediction only 159036997 Common - phage shock protein A, PspA Sare_1358 29 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 159037497 Common - hypothetical protein Sare_1874 8 None None None 159036067 Nonpathogen - hypothetical protein Sare_0400 9 None None None 159036477 Common - hypothetical protein Sare_0821 3 None None None 159036481 Nonpathogen - hypothetical protein Sare_0825 1 None None None 159037037 Common - luciferase family protein Sare_1399 48 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 159036449 Common - Carbamoyl-phosphate synthase L chain ATP-binding Sare_0792 234 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 159038600 Common - transposase IS4 family protein Sare_3041 7 None None None 159038343 Nonpathogen - transport-associated Sare_2770 2 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 159038014 Common - Erythromycin esterase Sare_2420 16 COG2312 COG2312, Erythromycin esterase homolog General function prediction only 159036683 Common - Alcohol dehydrogenase GroES domain protein Sare_1036 187 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 159037340 Common - regulator of chromosome condensation, RCC1 Sare_1715 31 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 159039057 Common - hypothetical protein Sare_3517 12 COG3688 COG3688, Predicted RNA-binding protein containing a PIN domain General function prediction only 159036300 Common - Antibiotic biosynthesis monooxygenase Sare_0640 52 COG1359 COG1359, Uncharacterized conserved protein Function unknown 159040483 Common - Glycerol-1-phosphate dehydrogenase (NAD(P)(+)) Sare_5002 95 COG0371 GldA, Glycerol dehydrogenase and related enzymes Energy production and conversion 159038712 Nonpathogen - hypothetical protein Sare_3166 1 None None None 159040052 Common - Abortive infection protein Sare_4542 19 None None None 159039398 Common - Nucleoside-diphosphate kinase Sare_3868 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 159037902 Nonpathogen - hypothetical protein Sare_2306 2 None None None 159037354 Common - helix-turn-helix domain protein Sare_1729 6 None None None 159035815 Common - acyl-CoA dehydrogenase domain protein Sare_0142 151 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159039036 Common - pyrroline-5-carboxylate reductase Sare_3496 215 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 159037190 Common - hypothetical protein Sare_1556 5 None None None 159038348 Common - diacylglycerol kinase catalytic region Sare_2775 72 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 159037872 Common - hypothetical protein Sare_2275 14 None None None 159036020 Common - MbtH domain protein Sare_0352 27 COG3251 COG3251, Uncharacterized protein conserved in bacteria Function unknown 159036387 Common - hypothetical protein Sare_0730 5 None None None 159038803 Common - drug resistance transporter, Bcr/CflA subfamily Sare_3262 137 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159039789 Common - ABC transporter related Sare_4270 249 COG1116 TauB, ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component Inorganic ion transport and metabolism 159037666 Common - hypothetical protein Sare_2061 36 COG4430 COG4430, Uncharacterized protein conserved in bacteria Function unknown 159039130 Common - protein of unknown function DUF81 Sare_3594 55 COG0730 COG0730, Predicted permeases General function prediction only 159039353 Common - ABC transporter related Sare_3822 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 159038615 Common - Orn/DAP/Arg decarboxylase 2 Sare_3058 206 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 159040449 Nonpathogen - TadE family protein Sare_4965 3 None None None 159040325 Common - cell divisionFtsK/SpoIIIE Sare_4837 101 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 159039846 Common - ribosomal protein L10 Sare_4327 207 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 159040586 Common - methyltransferase GidB Sare_5106 154 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 159036605 Common - DGPFAETKE family protein Sare_0955 41 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 159040226 Common - hypothetical protein Sare_4735 13 COG0433 COG0433, Predicted ATPase General function prediction only 159039210 Nonpathogen - hypothetical protein Sare_3678 1 None None None 159038453 Nonpathogen - hypothetical protein Sare_2889 3 None None None 159039747 Common - hypothetical protein Sare_4228 7 None None None 159038490 Nonpathogen - hypothetical protein Sare_2926 5 None None None 159037794 Common - hypothetical protein Sare_2195 9 None None None 159040256 Common - protein of unknown function DUF1446 Sare_4765 35 None None None 159035872 Common - hypothetical protein Sare_0199 40 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 159039647 Nonpathogen - hypothetical protein Sare_4119 1 None None None 159040314 Nonpathogen - hypothetical protein Sare_4826 2 None None None 159036525 Nonpathogen - hypothetical protein Sare_0869 1 None None None 159038505 Common - Radical SAM domain protein Sare_2941 101 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 159039297 Common - phage prohead protease, HK97 family Sare_3766 19 COG3740 COG3740, Phage head maturation protease General function prediction only 159038173 Common - hypothetical protein Sare_2594 46 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 159037462 Common - Shikimate kinase Sare_1839 183 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 159039422 Common - hypothetical protein Sare_3893 8 COG1512 COG1512, Beta-propeller domains of methanol dehydrogenase type General function prediction only 159038285 Common - cobaltochelatase, CobN subunit Sare_2710 89 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 159037640 Common - cytochrome P450 Sare_2032 69 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159039459 Common - single-strand binding protein Sare_3930 31 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 159036488 Nonpathogen - hypothetical protein Sare_0832 1 None None None 159038067 Common - Thymidine kinase Sare_2486 69 COG1435 Tdk, Thymidine kinase Nucleotide transport and metabolism 159036575 Common - SsrA-binding protein Sare_0920 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 159036893 Common - Acyl transferase Sare_1250 210 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159040249 Common - Redoxin domain protein Sare_4758 157 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 159040299 Common - transcriptional regulator, MarR family Sare_4811 17 COG1846 MarR, Transcriptional regulators Transcription 159040094 Nonpathogen - hypothetical protein Sare_4596 1 None None None 159038858 Common - transaldolase Sare_3317 122 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 159037749 Nonpathogen - hypothetical protein Sare_2146 4 None None None 159037136 Common - bifunctional deaminase-reductase domain protein Sare_1500 44 COG1985 RibD, Pyrimidine reductase, riboflavin biosynthesis Coenzyme metabolism 159037934 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Sare_2338 160 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 159036615 Common - protein of unknown function DUF427 Sare_0965 49 COG2343 COG2343, Uncharacterized protein conserved in bacteria Function unknown 159037828 Common - diguanylate cyclase Sare_2230 174 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 159037282 Nonpathogen - hypothetical protein Sare_1654 1 None None None 159037480 Common - Methionine adenosyltransferase Sare_1857 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 159036074 Common - Xylose isomerase domain protein TIM barrel Sare_0407 23 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 159038047 Nonpathogen - hypothetical protein Sare_2464 1 None None None 159039263 Nonpathogen - hypothetical protein Sare_3732 1 None None None 159039489 Nonpathogen - thymidylate kinase Sare_3961 4 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 159037818 Common - fatty acid desaturase Sare_2220 31 COG3239 DesA, Fatty acid desaturase Lipid metabolism 159039586 Common - phospholipid/glycerol acyltransferase Sare_4058 4 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 159039635 Common - phosphoribosylaminoimidazole-succinocarboxamide synthase Sare_4107 146 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 159037742 Common - amidohydrolase Sare_2139 79 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 159039943 Nonpathogen - hypothetical protein Sare_4430 1 None None None 159038365 Common - cobalt transport protein Sare_2792 19 COG1930 CbiN, ABC-type cobalt transport system, periplasmic component Inorganic ion transport and metabolism 159037652 Common - glycosyltransferase, MGT family Sare_2047 46 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 159038086 Nonpathogen - hypothetical protein Sare_2505 1 None None None 159038474 Nonpathogen - hypothetical protein Sare_2910 4 None None None 159040344 Common - two component transcriptional regulator, winged helix family Sare_4856 210 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159040047 Common - hypothetical protein Sare_4537 6 None None None 159040442 Common - MmgE/PrpD family protein Sare_4958 49 COG2079 PrpD, Uncharacterized protein involved in propionate catabolism General function prediction only 159039996 Nonpathogen - hypothetical protein Sare_4486 1 None None None 159039672 Nonpathogen - hypothetical protein Sare_4144 1 None None None 159036806 Common - helix-turn-helix domain protein Sare_1160 6 None None None 159036456 Common - hypothetical protein Sare_0799 9 None None None 159040430 Common - Domain of unknown function DUF1905 Sare_4946 4 None None None 159038898 Nonpathogen - hypothetical protein Sare_3358 1 None None None 159039926 Common - V-type H(+)-translocating pyrophosphatase Sare_4411 98 COG3808 OVP1, Inorganic pyrophosphatase Energy production and conversion 159040437 Nonpathogen - hypothetical protein Sare_4953 4 None None None 159036276 Nonpathogen - hypothetical protein Sare_0610 1 None None None 159039757 Common - Monosaccharide-transporting ATPase Sare_4238 115 COG4214 XylH, ABC-type xylose transport system, permease component Carbohydrate transport and metabolism 159039876 Common - Alcohol dehydrogenase zinc-binding domain protein Sare_4357 108 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 159040176 Common - protein of unknown function DUF397 Sare_4685 5 None None None 159038202 Common - hypothetical protein Sare_2624 4 None None None 159038764 Common - hypothetical protein Sare_3219 7 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 159039227 Nonpathogen - hypothetical protein Sare_3696 1 None None None 159035706 Common - pyruvate carboxyltransferase Sare_0032 197 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 159036499 Nonpathogen - hypothetical protein Sare_0843 1 None None None 159036560 Common - histidine kinase Sare_0905 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159037787 Common - aminotransferase class V Sare_2187 239 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 159038974 Common - protein of unknown function DUF552 Sare_3434 51 COG1799 COG1799, Uncharacterized protein conserved in bacteria Function unknown 159036645 Common - histidine ammonia-lyase Sare_0996 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 159037027 Common - recA protein Sare_1389 238 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 159037244 Nonpathogen - hypothetical protein Sare_1613 1 None None None 159036022 Common - diaminobutyrate--2-oxoglutarate aminotransferase Sare_0354 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 159035911 Common - aldehyde dehydrogenase Sare_0238 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 159038963 Common - peptidase S16 lon domain protein Sare_3423 76 COG2802 COG2802, Uncharacterized protein, similar to the N-terminal domain of Lon protease General function prediction only 159036413 Common - pyrimidine-nucleoside phosphorylase Sare_0756 119 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 159036723 Common - short-chain dehydrogenase/reductase SDR Sare_1077 197 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 159039745 Common - IMP dehydrogenase family protein Sare_4226 145 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 159039183 Common - hypothetical protein Sare_3647 14 None None None 159039903 Nonpathogen - hypothetical protein Sare_4384 1 None None None 159035891 Common - hypothetical protein Sare_0218 108 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 159038703 Common - alpha/beta hydrolase fold Sare_3157 134 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159039411 Common - protein of unknown function DUF574 Sare_3882 13 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 159040481 Common - putative signal-transduction protein with CBS domains Sare_5000 132 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 159036054 Common - regulatory protein TetR Sare_0387 30 None None None 159038132 Common - extracellular solute-binding protein family 1 Sare_2552 74 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 159038283 Common - cob(I)alamin adenosyltransferase Sare_2708 141 COG2109 BtuR, ATP:corrinoid adenosyltransferase Coenzyme metabolism 159039017 Common - 5,10-methylenetetrahydrofolate reductase Sare_3477 151 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 159038932 Common - Glutamate synthase (ferredoxin) Sare_3392 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 159038217 Common - Serine-type D-Ala-D-Ala carboxypeptidase Sare_2640 134 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 159036164 Nonpathogen - hypothetical protein Sare_0497 1 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 159037944 Common - major facilitator superfamily MFS_1 Sare_2348 170 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159039234 Nonpathogen - hypothetical protein Sare_3703 1 None None None 159040050 Common - transcriptional regulator, XRE family Sare_4540 200 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 159038479 Common - histidine kinase Sare_2915 219 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 159035840 Common - hypothetical protein Sare_0167 15 None None None 159039087 Nonpathogen - hypothetical protein Sare_3547 2 None None None 159040115 Nonpathogen - hypothetical protein Sare_4619 1 None None None 159040297 Nonpathogen - hypothetical protein Sare_4809 1 COG1592 COG1592, Rubrerythrin Energy production and conversion 159038991 Common - leucyl-tRNA synthetase Sare_3451 248 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159039504 Common - hypothetical protein Sare_3976 62 COG2706 COG2706, 3-carboxymuconate cyclase Carbohydrate transport and metabolism 159039170 Common - transport-associated Sare_3634 40 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 159037300 Common - DNA gyrase subunit B domain protein Sare_1674 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 159036322 Common - protein of unknown function DUF59 Sare_0662 228 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 159037111 Common - protoporphyrinogen oxidase Sare_1475 47 COG1232 HemY, Protoporphyrinogen oxidase Coenzyme metabolism 159039097 Common - aldo/keto reductase Sare_3557 195 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 159035849 Common - hypothetical protein Sare_0176 15 COG1510 COG1510, Predicted transcriptional regulators Transcription 159035818 Common - SNARE associated Golgi protein Sare_0145 55 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 159036259 Common - putative monooxygenase Sare_0593 50 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 159040076 Common - putative transposase Sare_4571 50 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 159035935 Common - aspartate kinase Sare_0265 233 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 159035749 Common - two component transcriptional regulator, winged helix family Sare_0076 218 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159040401 Nonpathogen - hypothetical protein Sare_4915 1 None None None 159036145 Nonpathogen - hypothetical protein Sare_0478 1 None None None 159040189 Nonpathogen - hypothetical protein Sare_4698 1 None None None 159035692 Nonpathogen - hypothetical protein Sare_0018 1 None None None 159037595 Common - CRISPR-associated protein, Cse1 family Sare_1972 18 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 159037357 Common - GCN5-related N-acetyltransferase Sare_1732 13 COG0456 RimI, Acetyltransferases General function prediction only 159037381 Common - cysteine desulfurase family protein Sare_1756 215 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 159037996 Common - Alcohol dehydrogenase zinc-binding domain protein Sare_2400 168 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 159038034 Common - protein serine/threonine phosphatase Sare_2449 112 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 159038998 Common - ATPase associated with various cellular activities AAA_3 Sare_3458 174 COG0714 COG0714, MoxR-like ATPases General function prediction only 159039284 Nonpathogen - hypothetical protein Sare_3753 1 None None None 159037769 Common - Radical SAM domain protein Sare_2167 52 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 159037406 Common - ABC transporter related Sare_1781 249 COG4152 COG4152, ABC-type uncharacterized transport system, ATPase component General function prediction only 159039888 Nonpathogen - protein of unknown function DUF81 Sare_4369 4 COG0730 COG0730, Predicted permeases General function prediction only 159038413 Common - hypothetical protein Sare_2840 44 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 159036467 Common - HAD-superfamily hydrolase, subfamily IIB Sare_0810 75 COG1877 OtsB, Trehalose-6-phosphatase Carbohydrate transport and metabolism 159039792 Nonpathogen - hypothetical protein Sare_4273 1 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 159038928 Common - ABC-2 type transporter Sare_3388 5 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 159039429 Common - pyruvate carboxyltransferase Sare_3900 51 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 159037350 Common - aldehyde dehydrogenase Sare_1725 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 159036926 Nonpathogen - hypothetical protein Sare_1284 1 None None None 159035787 Common - chaperone protein DnaJ Sare_0114 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 159037186 Common - hypothetical protein Sare_1552 35 COG3973 COG3973, Superfamily I DNA and RNA helicases General function prediction only 159038268 Common - monooxygenase FAD-binding Sare_2693 69 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 159038623 Nonpathogen - hypothetical protein Sare_3066 1 None None None 159037866 Common - Oxidoreductase FAD-binding domain protein Sare_2269 31 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 159035780 Common - catalytic domain of components of various dehydrogenase complexes Sare_0107 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 159038516 Common - methylaspartate mutase E subunit Sare_2952 17 COG4865 COG4865, Glutamate mutase epsilon subunit Amino acid transport and metabolism 159039290 Nonpathogen - hypothetical protein Sare_3759 1 None None None 159037387 Common - cold-shock DNA-binding domain protein Sare_1762 181 COG1278 CspC, Cold shock proteins Transcription 159036173 Common - major facilitator superfamily MFS_1 Sare_0506 140 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159038545 Common - transposase IS116/IS110/IS902 family protein Sare_2982 13 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 159036250 Nonpathogen - hypothetical protein Sare_0584 1 None None None 159036380 Nonpathogen - hypothetical protein Sare_0723 1 None None None 159035858 Nonpathogen - hypothetical protein Sare_0185 1 None None None 159037390 Common - Trans-aconitate 2-methyltransferase Sare_1765 74 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 159036112 Common - short-chain dehydrogenase/reductase SDR Sare_0445 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159039785 Common - histidine kinase Sare_4266 37 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159038701 Common - cytochrome P450 Sare_3155 90 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159036282 Common - aldo/keto reductase Sare_0617 203 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 159040044 Common - FAD linked oxidase domain protein Sare_4534 42 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 159038718 Common - protein of unknown function DUF1697 Sare_3173 36 COG3797 COG3797, Uncharacterized protein conserved in bacteria Function unknown 159039466 Nonpathogen - hypothetical protein Sare_3938 1 None None None 159036016 Common - transcriptional regulator, LuxR family Sare_0348 67 COG3899 COG3899, Predicted ATPase General function prediction only 159037090 Common - deoxyribonuclease/rho motif-related TRAM Sare_1453 173 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 159036592 Common - cell divisionFtsK/SpoIIIE Sare_0939 165 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 159039127 Common - NADPH-dependent F420 reductase Sare_3589 40 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 159037420 Common - transcriptional regulator, CdaR Sare_1796 63 COG3835 CdaR, Sugar diacid utilization regulator Transcription / Signal transduction mechanisms 159039581 Common - ornithine aminotransferase Sare_4053 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 159037772 Common - extracellular solute-binding protein family 5 Sare_2171 86 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 159036201 Common - copper ion binding protein Sare_0534 73 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 159040065 Common - transcriptional regulator, LuxR family Sare_4559 25 COG3899 COG3899, Predicted ATPase General function prediction only 159039324 Nonpathogen - helix-turn-helix domain protein Sare_3793 1 None None None 159039907 Common - hypothetical protein Sare_4391 13 None None None 159039536 Common - ATP--cobalamin adenosyltransferase Sare_4008 129 COG2096 COG2096, Uncharacterized conserved protein Function unknown 159039618 Common - drug resistance transporter, EmrB/QacA subfamily Sare_4090 190 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159039546 Common - ATP synthase F0, A subunit Sare_4018 203 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 159038824 Common - asparagine synthase (glutamine-hydrolyzing) Sare_3283 157 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 159037399 Common - lipid A biosynthesis acyltransferase Sare_1774 52 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 159037604 Common - hypothetical protein Sare_1983 4 None None None 159037779 Common - Beta-ketoacyl synthase Sare_2179 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159038385 Common - acetyl-CoA acetyltransferase Sare_2812 172 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 159037450 Nonpathogen - hypothetical protein Sare_1826 1 COG3307 RfaL, Lipid A core - O-antigen ligase and related enzymes Cell envelope biogenesis, outer membrane 159038955 Common - transcriptional regulator, MarR family Sare_3415 98 COG1846 MarR, Transcriptional regulators Transcription 159037367 Common - hypothetical protein Sare_1742 10 None None None 159038941 Common - Phosphoribosyl-AMP cyclohydrolase Sare_3401 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 159040028 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Sare_4518 91 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 159038758 Common - acyltransferase 3 Sare_3213 8 COG3594 NolL, Fucose 4-O-acetylase and related acetyltransferases Carbohydrate transport and metabolism 159040410 Common - IstB domain protein ATP-binding protein Sare_4925 98 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 159037714 Nonpathogen - GCN5-related N-acetyltransferase Sare_2111 2 COG4552 Eis, Predicted acetyltransferase involved in intracellular survival and related acetyltransferases General function prediction only 159036990 Common - cell divisionFtsK/SpoIIIE Sare_1351 198 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 159037086 Common - hypothetical protein Sare_1449 13 None None None 159038422 Common - hypothetical protein Sare_2850 6 None None None 159038891 Nonpathogen - SNARE associated Golgi protein Sare_3351 2 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 159037637 Common - Beta-ketoacyl synthase Sare_2029 210 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159036871 Common - transcriptional regulator, GntR family Sare_1226 25 COG2188 PhnF, Transcriptional regulators Transcription 159040521 Common - transcriptional regulator, AsnC family Sare_5040 152 COG1522 Lrp, Transcriptional regulators Transcription 159038570 Common - cytochrome P450 Sare_3008 73 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159035831 Common - phosphoribosylformylglycinamidine synthase I Sare_0158 228 COG0047 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain Nucleotide transport and metabolism 159038896 Common - MMPL domain protein Sare_3356 26 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 159039674 Common - Dipeptidyl-peptidase IV Sare_4146 89 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 159036207 Common - hypothetical protein Sare_0540 6 COG3483 TDO2, Tryptophan 2,3-dioxygenase (vermilion) Amino acid transport and metabolism 159038031 Nonpathogen - hypothetical protein Sare_2445 1 None None None 159035876 Common - (2Fe-2S)-binding domain protein Sare_0203 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 159037656 Common - Resolvase domain Sare_2051 45 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 159040089 Common - major facilitator superfamily MFS_1 Sare_4586 43 None None None 159035811 Nonpathogen - hypothetical protein Sare_0138 1 None None None 159037494 Common - 6,7-dimethyl-8-ribityllumazine synthase Sare_1871 130 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 159038112 Nonpathogen - hypothetical protein Sare_2531 2 None None None 159038168 Common - hypothetical protein Sare_2589 3 None None None 159039207 Common - hypothetical protein Sare_3675 9 None None None 159037963 Common - hypothetical protein Sare_2367 22 COG2378 COG2378, Predicted transcriptional regulator Transcription 159040279 Common - beta-lactamase domain protein Sare_4788 92 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 159039365 Common - protein of unknown function DUF558 Sare_3834 168 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 159040019 Common - Pyridoxal-5'-phosphate-dependent protein beta subunit Sare_4509 145 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 159037927 Common - cytochrome P450 Sare_2331 85 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159039643 Nonpathogen - hypothetical protein Sare_4115 6 None None None 159036333 Common - acyl-CoA dehydrogenase domain protein Sare_0673 164 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159039616 Common - Glutamine--fructose-6-phosphate transaminase (isomerizing) Sare_4088 235 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 159036840 Common - ribosomal protein S16 Sare_1194 213 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 159040573 Common - integral membrane protein MviN Sare_5093 170 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 159040330 Common - hypothetical protein Sare_4842 31 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 159037739 Common - two component transcriptional regulator, LuxR family Sare_2136 168 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159037726 Common - short-chain dehydrogenase/reductase SDR Sare_2123 56 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159038232 Common - heat shock protein Hsp90 Sare_2657 150 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 159037429 Common - (p)ppGpp synthetase I, SpoT/RelA Sare_1805 207 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 159037784 Common - glucose-1-phosphate thymidylyltransferase Sare_2184 232 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 159039091 Common - dihydrolipoamide dehydrogenase Sare_3551 242 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 159038163 Common - ABC-2 type transporter Sare_2584 191 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 159039387 Common - hypothetical protein Sare_3857 8 None None None 159037644 Common - glycosyltransferase, MGT family Sare_2036 45 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 159036406 Common - binding-protein-dependent transport systems inner membrane component Sare_0749 187 COG3833 MalG, ABC-type maltose transport systems, permease component Carbohydrate transport and metabolism 159037458 Common - YD repeat protein Sare_1834 41 COG3209 RhsA, Rhs family protein Cell envelope biogenesis, outer membrane 159040030 Common - glutamate-1-semialdehyde-2,1-aminomutase Sare_4520 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 159039808 Common - ribosomal protein S13 Sare_4289 242 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 159037519 Common - tyrosyl-tRNA synthetase Sare_1896 216 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159039920 Common - hypothetical protein Sare_4405 14 COG3616 COG3616, Predicted amino acid aldolase or racemase Amino acid transport and metabolism 159039345 Common - periplasmic solute binding protein Sare_3814 167 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 159036915 Common - Transketolase domain protein Sare_1272 202 COG3959 COG3959, Transketolase, N-terminal subunit Carbohydrate transport and metabolism 159040386 Common - glycoside hydrolase family 12 Sare_4899 20 None None None 159038944 Common - transcriptional regulator, TetR family Sare_3404 32 COG1309 AcrR, Transcriptional regulator Transcription 159040123 Common - protein of unknown function DUF1486 Sare_4627 9 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 159037157 Common - transcriptional regulator, TetR family Sare_1523 53 COG1309 AcrR, Transcriptional regulator Transcription 159039014 Common - glycosyl transferase family 2 Sare_3474 43 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 159037777 Common - ASPIC/UnbV domain protein Sare_2177 11 None None None 159039002 Common - DNA-directed DNA polymerase Sare_3462 186 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 159035751 Common - major facilitator superfamily MFS_1 Sare_0078 166 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159037535 Common - NUDIX hydrolase Sare_1912 122 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 159039763 Common - uracil-DNA glycosylase Sare_4244 128 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 159039433 Common - Kynurenine 3-monooxygenase Sare_3904 80 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 159037613 Common - transposase IS4 family protein Sare_1998 4 None None None 159038593 Common - protein of unknown function DUF262 Sare_3033 50 COG3472 COG3472, Uncharacterized conserved protein Function unknown 159036210 Common - peptidase M24 Sare_0543 229 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 159037565 Common - hypothetical protein Sare_1942 4 None None None 159037510 Common - Argininosuccinate synthase Sare_1887 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 159036385 Common - ABC transporter related Sare_0728 238 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 159036288 Nonpathogen - hypothetical protein Sare_0627 1 None None None 159035925 Common - extracellular solute-binding protein family 5 Sare_0255 190 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 159036138 Common - proton-translocating NADH-quinone oxidoreductase, chain L Sare_0471 205 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 159036563 Common - sigma 54 modulation protein/ribosomal protein S30EA Sare_0908 67 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 159038725 Common - glycoside hydrolase family 48 Sare_3180 34 COG5297 CelA, Cellobiohydrolase A (1,4-beta-cellobiosidase A) Carbohydrate transport and metabolism 159039702 Common - Methenyltetrahydrofolate cyclohydrolase Sare_4175 223 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 159036779 Common - 2-isopropylmalate synthase/homocitrate synthase family protein Sare_1133 197 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 159039514 Common - NAD-glutamate dehydrogenase Sare_3986 77 COG2902 COG2902, NAD-specific glutamate dehydrogenase Amino acid transport and metabolism 159038768 Common - transcriptional regulator, BadM/Rrf2 family Sare_3223 87 COG1959 COG1959, Predicted transcriptional regulator Transcription 159040553 Nonpathogen - hypothetical protein Sare_5072 1 None None None 159039935 Nonpathogen - hypothetical protein Sare_4420 1 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 159037075 Common - type III restriction protein res subunit Sare_1438 34 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 159040417 Common - cytochrome P450 Sare_4932 80 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159038810 Nonpathogen - hypothetical protein Sare_3269 1 None None None 159038628 Nonpathogen - hypothetical protein Sare_3074 1 None None None 159039989 Nonpathogen - hypothetical protein Sare_4477 3 None None None 159036720 Common - FAD linked oxidase domain protein Sare_1074 198 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 159038909 Common - RNA binding S1 domain protein Sare_3369 225 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 159039934 Common - type II secretion system protein Sare_4419 12 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 159037227 Common - hypothetical protein Sare_1596 5 None None None 159035700 Common - CBS domain containing protein Sare_0026 154 COG0517 COG0517, FOG: CBS domain General function prediction only 159037618 Nonpathogen - hypothetical protein Sare_2004 1 None None None 159037294 Common - hypothetical protein Sare_1668 5 None None None 159037762 Common - ferric uptake regulator, Fur family Sare_2159 158 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 159037017 Common - protein of unknown function DUF397 Sare_1379 6 None None None 159038429 Nonpathogen - Peptidoglycan-binding domain 1 protein Sare_2857 2 COG2989 COG2989, Uncharacterized protein conserved in bacteria Function unknown 159037987 Common - hypothetical protein Sare_2391 18 None None None 159039961 Common - Polyprenyl synthetase Sare_4449 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 159036861 Nonpathogen - hypothetical protein Sare_1216 1 None None None 159037807 Common - Carnitine O-acetyltransferase Sare_2208 7 None None None 159035734 Common - NLP/P60 protein Sare_0060 131 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 159040421 Common - daunorubicin resistance ABC transporter ATPase subunit Sare_4937 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159037361 Common - adenosylhomocysteinase Sare_1736 177 COG0499 SAM1, S-adenosylhomocysteine hydrolase Coenzyme metabolism 159040058 Common - transcriptional regulator, winged helix family Sare_4552 28 COG3903 COG3903, Predicted ATPase General function prediction only 159037830 Common - hypothetical protein Sare_2232 6 None None None 159039133 Common - protein of unknown function DUF34 Sare_3597 124 COG0327 COG0327, Uncharacterized conserved protein Function unknown 159038736 Nonpathogen - hypothetical protein Sare_3191 3 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 159035768 Common - urea amidolyase related protein Sare_0095 113 COG1984 DUR1, Allophanate hydrolase subunit 2 Amino acid transport and metabolism 159035988 Nonpathogen - hypothetical protein Sare_0320 1 None None None 159036156 Nonpathogen - hypothetical protein Sare_0489 1 None None None 159038507 Nonpathogen - bifunctional deaminase-reductase domain protein Sare_2943 4 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 159038611 Nonpathogen - 4'-phosphopantetheinyl transferase Sare_3054 1 COG2091 Sfp, Phosphopantetheinyl transferase Coenzyme metabolism 159039562 Common - diaminopimelate decarboxylase Sare_4034 218 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 159035709 Common - transcriptional regulator, XRE family Sare_0035 24 COG3903 COG3903, Predicted ATPase General function prediction only 159035981 Common - GCN5-related N-acetyltransferase Sare_0313 15 COG3153 COG3153, Predicted acetyltransferase General function prediction only 159036348 Common - 5-formyltetrahydrofolate cyclo-ligase Sare_0690 8 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 159038866 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Sare_3325 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 159036815 Common - DEAD/DEAH box helicase domain protein Sare_1169 210 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 159038257 Nonpathogen - Antibiotic biosynthesis monooxygenase Sare_2682 3 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 159037731 Common - protein of unknown function DUF397 Sare_2128 6 None None None 159037080 Common - hypothetical protein Sare_1443 19 None None None 159039621 Common - biotin/lipoyl attachment domain-containing protein Sare_4093 157 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 159038568 Common - PfkB domain protein Sare_3006 81 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 159038495 Common - ATPase-like protein Sare_2931 62 COG3899 COG3899, Predicted ATPase General function prediction only 159036911 Common - monooxygenase FAD-binding Sare_1268 127 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 159040535 Common - DoxX family protein Sare_5054 15 COG2259 COG2259, Predicted membrane protein Function unknown 159037129 Nonpathogen - hypothetical protein Sare_1493 1 None None None 159039376 Nonpathogen - hypothetical protein Sare_3845 1 None None None 159039567 Common - DNA polymerase LigD polymerase domain Sare_4039 66 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 159040070 Common - isopentenyl-diphosphate delta-isomerase, type 1 Sare_4564 51 COG1443 Idi, Isopentenyldiphosphate isomerase Lipid metabolism 159038870 Common - Protein-L-isoaspartate(D-aspartate) O-methyltransferase Sare_3329 139 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 159040272 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Sare_4781 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 159035740 Common - protein of unknown function DUF1470 Sare_0066 6 COG5516 COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding General function prediction only 159036097 Common - Endonuclease/exonuclease/phosphatase Sare_0430 41 COG2374 COG2374, Predicted extracellular nuclease General function prediction only 159036716 Common - FAD dependent oxidoreductase Sare_1069 94 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159039105 Nonpathogen - hypothetical protein Sare_3565 1 None None None 159038170 Common - hypothetical protein Sare_2591 3 COG1944 COG1944, Uncharacterized conserved protein Function unknown 159038815 Nonpathogen - Lantibiotic dehydratase domain protein Sare_3274 4 None None None 159040260 Common - acyl-CoA dehydrogenase domain protein Sare_4769 155 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159039152 Nonpathogen - hypothetical protein Sare_3616 1 None None None 159039778 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Sare_4259 183 COG1251 NirB, NAD(P)H-nitrite reductase Energy production and conversion 159038920 Common - protein of unknown function DUF81 Sare_3380 25 COG0730 COG0730, Predicted permeases General function prediction only 159039470 Common - Amylo-alpha-16-glucosidase Sare_3942 52 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 159038243 Common - protein of unknown function DUF407 Sare_2668 8 COG0754 Gsp, Glutathionylspermidine synthase Amino acid transport and metabolism 159035956 Common - ROK family protein Sare_0287 39 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 159037549 Nonpathogen - Bifunctional DNA primase/polymerase Sare_1926 7 None None None 159039814 Common - preprotein translocase, SecY subunit Sare_4295 221 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 159036796 Common - 3-isopropylmalate dehydratase, small subunit Sare_1150 208 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 159037277 Common - putative transposase Sare_1649 50 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 159039185 Nonpathogen - hypothetical protein Sare_3649 1 None None None 159037152 Common - biotin synthase Sare_1518 183 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 159037176 Common - hypothetical protein Sare_1542 11 None None None 159036270 Nonpathogen - putative O-methyltransferase Sare_0604 3 None None None 159038100 Common - transcriptional regulator, MerR family Sare_2519 19 COG0789 SoxR, Predicted transcriptional regulators Transcription 159036472 Common - hypothetical protein Sare_0815 13 None None None 159037689 Common - GCN5-related N-acetyltransferase Sare_2086 30 COG4552 Eis, Predicted acetyltransferase involved in intracellular survival and related acetyltransferases General function prediction only 159036131 Common - NADH dehydrogenase (quinone) Sare_0464 181 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 159038324 Nonpathogen - hypothetical protein Sare_2751 17 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 159036930 Common - histidine kinase Sare_1289 73 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159037677 Common - extracellular solute-binding protein family 5 Sare_2073 190 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 159036880 Nonpathogen - hypothetical protein Sare_1236 1 None None None 159039579 Common - pyridine nucleotide-disulphide oxidoreductase dimerisation region Sare_4051 241 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 159037879 Common - sulfatase Sare_2283 24 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 159037338 Nonpathogen - hypothetical protein Sare_1713 1 None None None 159036867 Common - hypothetical protein Sare_1222 4 None None None 159036446 Common - transcriptional regulator, MarR family Sare_0789 42 COG1846 MarR, Transcriptional regulators Transcription 159037214 Nonpathogen - hypothetical protein Sare_1581 1 None None None 159036948 Common - transcriptional regulator, PadR-like family Sare_1309 73 COG1695 COG1695, Predicted transcriptional regulators Transcription 159039080 Common - hypothetical protein Sare_3540 12 None None None 159038072 Common - luciferase family protein Sare_2491 88 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 159040452 Common - type II secretion system protein Sare_4968 8 COG4965 TadB, Flp pilus assembly protein TadB Intracellular trafficking and secretion 159038532 Common - transcriptional regulator, XRE family Sare_2968 6 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 159037099 Common - hypothetical protein Sare_1462 19 COG1510 COG1510, Predicted transcriptional regulators Transcription 159037061 Common - CoA-binding domain protein Sare_1423 164 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 159036533 Nonpathogen - hypothetical protein Sare_0877 1 None None None 159039448 Common - HAD-superfamily hydrolase, subfamily IIB Sare_3919 94 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 159036544 Common - Radical SAM domain protein Sare_0888 89 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 159035759 Common - acyl-CoA dehydrogenase domain protein Sare_0086 142 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159038395 Common - acyl-CoA dehydrogenase domain protein Sare_2822 142 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159040420 Common - ABC-2 type transporter Sare_4936 153 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 159036185 Common - L-serine dehydratase 1 Sare_0518 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 159039740 Common - NUDIX hydrolase Sare_4221 59 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 159038312 Common - L-lysine 6-monooxygenase (NADPH) Sare_2739 54 COG3486 IucD, Lysine/ornithine N-monooxygenase Secondary metabolites biosynthesis, transport, and catabolism 159037087 Common - TrkA-N domain protein Sare_1450 142 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 159037559 Common - isochorismatase hydrolase Sare_1936 9 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 159038879 Common - Rieske (2Fe-2S) domain protein Sare_3338 29 COG2146 {NirD}, Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases Inorganic ion transport and metabolism / General function prediction only 159038302 Common - glutamate--cysteine ligase GCS2 Sare_2729 63 COG2170 COG2170, Uncharacterized conserved protein Function unknown 159040082 Common - UspA domain protein Sare_4577 12 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 159039198 Common - S-adenosylmethionine synthetase-like protein Sare_3663 25 COG1812 MetK, Archaeal S-adenosylmethionine synthetase Amino acid transport and metabolism 159035689 Nonpathogen - regulator of chromosome condensation, RCC1 Sare_0015 1 None None None 159040500 Common - NAD-dependent epimerase/dehydratase Sare_5019 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 159038077 Common - transcriptional regulator, MarR family Sare_2496 44 COG1846 MarR, Transcriptional regulators Transcription 159038630 Nonpathogen - hypothetical protein Sare_3076 1 None None None 159037695 Common - histidine ammonia-lyase Sare_2092 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 159036042 Common - ferric uptake regulator, Fur family Sare_0375 177 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 159038655 Common - putative transposase Sare_3107 50 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 159036824 Common - formamidopyrimidine-DNA glycosylase Sare_1178 181 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 159040494 Common - hypothetical protein Sare_5013 3 None None None 159040142 Common - hypothetical protein Sare_4647 46 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 159036692 Common - FAD dependent oxidoreductase Sare_1045 3 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 159036963 Common - protein of unknown function DUF150 Sare_1324 14 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 159036514 Common - peptidase M42 family protein Sare_0858 55 COG1363 FrvX, Cellulase M and related proteins Carbohydrate transport and metabolism 159036084 Common - major facilitator superfamily MFS_1 Sare_0417 114 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159038984 Common - Peptidoglycan glycosyltransferase Sare_3444 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 159036751 Common - ATPase, P-type (transporting), HAD superfamily, subfamily IC Sare_1105 231 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 159040033 Common - GAF sensor hybrid histidine kinase Sare_4523 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159038022 Common - transcriptional regulator, XRE family Sare_2429 113 COG1396 HipB, Predicted transcriptional regulators Transcription 159039527 Common - hypothetical protein Sare_3999 14 None None None 159035918 Nonpathogen - hypothetical protein Sare_0248 1 None None None 159036550 Common - aldehyde dehydrogenase Sare_0895 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 159038166 Common - hypothetical protein Sare_2587 5 None None None 159039259 Nonpathogen - hypothetical protein Sare_3728 1 None None None 159038770 Common - protein of unknown function ATP binding Sare_3225 16 COG2229 COG2229, Predicted GTPase General function prediction only 159038851 Common - FeS assembly protein SufB Sare_3310 186 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 159035723 Common - protein serine/threonine phosphatase Sare_0049 132 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 159037253 Common - binding-protein-dependent transport systems inner membrane component Sare_1623 127 COG1174 OpuBB, ABC-type proline/glycine betaine transport systems, permease component Amino acid transport and metabolism 159035993 Common - protein of unknown function DUF47 Sare_0325 69 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 159037757 Nonpathogen - 3-Oxoacyl-(acyl-carrier-protein (ACP)) synthase III domain protein Sare_2154 9 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 159036891 Common - Beta-ketoacyl synthase Sare_1248 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159036603 Common - hypothetical protein Sare_0951 13 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 159036784 Common - peptidase S1 and S6 chymotrypsin/Hap Sare_1138 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 159036833 Common - ammonium transporter Sare_1187 201 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 159037445 Common - aminodeoxychorismate lyase Sare_1821 178 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 159035970 Nonpathogen - hypothetical protein Sare_0302 1 COG1274 PckA, Phosphoenolpyruvate carboxykinase (GTP) Energy production and conversion 159036232 Common - Adenylosuccinate synthase Sare_0566 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 159040105 Common - MIP family channel protein Sare_4609 134 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 159039472 Common - putative signal-transduction protein with CBS domains Sare_3944 53 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 159038378 Common - coenzyme A transferase Sare_2805 35 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 159037468 Common - Uracil phosphoribosyltransferase Sare_1845 114 COG2065 PyrR, Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase Nucleotide transport and metabolism 159039135 Common - transcriptional regulator, XRE family Sare_3599 6 COG1396 HipB, Predicted transcriptional regulators Transcription 159040141 Common - hypothetical protein Sare_4646 4 None None None 159036685 Common - Saccharopine dehydrogenase Sare_1038 11 COG1748 LYS9, Saccharopine dehydrogenase and related proteins Amino acid transport and metabolism 159036183 Common - hypothetical protein Sare_0516 13 COG5450 COG5450, Transcription regulator of the Arc/MetJ class Transcription 159038319 Common - hypothetical protein Sare_2746 47 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 159039409 Common - trigger factor Sare_3879 215 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 159037169 Common - hypothetical protein Sare_1535 72 COG2843 PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) Cell envelope biogenesis, outer membrane 159037440 Nonpathogen - hypothetical protein Sare_1816 1 None None None 159036535 Common - acetoacetyl-CoA synthase Sare_0879 199 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 159036869 Common - regulator Sare_1224 6 None None None 159039591 Common - histidine kinase Sare_4063 192 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159036486 Nonpathogen - hypothetical protein Sare_0830 1 None None None 159036286 Nonpathogen - hypothetical protein Sare_0623 1 None None None 159036293 Common - transcriptional regulator, AsnC family Sare_0632 149 COG1522 Lrp, Transcriptional regulators Transcription 159039650 Common - major facilitator superfamily MFS_1 Sare_4122 58 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 159040312 Common - coagulation factor 5/8 type domain protein Sare_4824 16 COG3170 FimV, Tfp pilus assembly protein FimV Cell motility and secretion / Intracellular trafficking and secretion 159035746 Common - transcriptional regulator, ArsR family Sare_0073 48 COG0640 ArsR, Predicted transcriptional regulators Transcription 159038487 Common - hypothetical protein Sare_2923 13 COG0439 AccC, Biotin carboxylase Lipid metabolism 159040407 Common - protein of unknown function UPF0150 Sare_4921 39 COG1598 COG1598, Uncharacterized conserved protein Function unknown 159037682 Common - Methyltransferase type 12 Sare_2078 25 None None None 159037132 Common - SMC domain protein Sare_1496 101 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 159038016 Common - hypothetical protein Sare_2423 35 COG4335 COG4335, DNA alkylation repair enzyme DNA replication, recombination, and repair 159036428 Common - Aldehyde dehydrogenase (NAD(+)) Sare_0771 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 159039335 Common - Siderophore-interacting protein Sare_3804 64 COG2375 ViuB, Siderophore-interacting protein Inorganic ion transport and metabolism 159038363 Common - cobalt ABC transporter, ATPase subunit Sare_2790 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 159038511 Nonpathogen - hypothetical protein Sare_2947 1 None None None 159039278 Nonpathogen - hypothetical protein Sare_3747 1 None None None 159039271 Common - prophage antirepressor Sare_3740 38 COG3617 COG3617, Prophage antirepressor Transcription 159036203 Common - heavy metal translocating P-type ATPase Sare_0536 230 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 159036314 Common - Enoyl-CoA hydratase/isomerase Sare_0654 152 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 159036470 Nonpathogen - hypothetical protein Sare_0813 1 None None None 159039021 Common - apurinic endonuclease Apn1 Sare_3481 99 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 159036956 Common - protein of unknown function DUF574 Sare_1317 12 None None None 159037889 Common - hypothetical protein Sare_2293 5 None None None 159037583 Common - peptidase S9 prolyl oligopeptidase active site domain protein Sare_1960 82 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 159035961 Common - GCN5-related N-acetyltransferase Sare_0292 3 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 159037043 Common - Bilirubin oxidase Sare_1405 79 COG2132 SufI, Putative multicopper oxidases Secondary metabolites biosynthesis, transport, and catabolism 159036923 Common - YD repeat protein Sare_1280 55 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 159038457 Common - transcriptional regulator, GntR family Sare_2893 116 COG2188 PhnF, Transcriptional regulators Transcription 159040078 Nonpathogen - hypothetical protein Sare_4573 1 None None None 159036735 Common - histidine kinase Sare_1089 219 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 159035808 Common - fructose-bisphosphate aldolase, class II Sare_0135 117 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 159040305 Common - hypothetical protein Sare_4817 6 None None None 159036896 Common - 3-dehydroquinate synthase Sare_1253 209 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 159038310 Common - IucA/IucC family protein Sare_2737 49 COG4264 RhbC, Siderophore synthetase component Secondary metabolites biosynthesis, transport, and catabolism 159038004 Common - Alcohol dehydrogenase zinc-binding domain protein Sare_2409 140 COG2130 COG2130, Putative NADP-dependent oxidoreductases General function prediction only 159039729 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Sare_4210 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 159039639 Common - hypothetical protein Sare_4111 35 COG3480 SdrC, Predicted secreted protein containing a PDZ domain Signal transduction mechanisms 159037969 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Sare_2373 6 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 159039645 Common - ABC-1 domain protein Sare_4117 185 COG0661 AarF, Predicted unusual protein kinase General function prediction only 159036461 Common - membrane-flanked domain Sare_0804 16 COG3428 COG3428, Predicted membrane protein Function unknown 159036658 Common - cobalt ABC transporter, ATPase subunit Sare_1009 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 159038024 Nonpathogen - hypothetical protein Sare_2434 7 None None None 159040201 Common - hypothetical protein Sare_4710 17 None None None 159038986 Common - S-adenosyl-methyltransferase MraW Sare_3446 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 159037370 Common - Dolichyl-phosphate beta-D-mannosyltransferase Sare_1745 136 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 159039066 Common - cytochrome c class I Sare_3526 19 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 159038428 Common - amidohydrolase 2 Sare_2856 43 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 159040353 Nonpathogen - hypothetical protein Sare_4865 1 None None None 159035860 Common - DSBA oxidoreductase Sare_0187 62 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 159036035 Common - peptidase S8 and S53 subtilisin kexin sedolisin Sare_0368 122 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 159037265 Common - transcriptional regulator, LuxR family Sare_1635 14 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159040163 Common - SCP-like extracellular Sare_4672 61 COG2340 COG2340, Uncharacterized protein with SCP/PR1 domains Function unknown 159040369 Common - hypothetical protein Sare_4881 5 None None None 159035941 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sare_0272 79 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159040543 Common - phosphoribosyltransferase Sare_5062 69 COG1926 COG1926, Predicted phosphoribosyltransferases General function prediction only 159037750 Common - amidinotransferase Sare_2147 32 COG1834 COG1834, N-Dimethylarginine dimethylaminohydrolase Amino acid transport and metabolism 159039666 Common - protein of unknown function DUF541 Sare_4138 5 COG2968 COG2968, Uncharacterized conserved protein Function unknown 159037077 Common - RNA polymerase, sigma 70 subunit, RpoD family Sare_1440 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 159040212 Common - NADH dehydrogenase (quinone) Sare_4721 191 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 159036440 Common - transcriptional regulator, XRE family Sare_0783 6 COG1396 HipB, Predicted transcriptional regulators Transcription 159037752 Common - Methionine--tRNA ligase Sare_2149 192 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159036504 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Sare_0848 196 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 159040006 Common - glycyl-tRNA synthetase, beta subunit Sare_4496 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 159039765 Common - alpha/beta hydrolase fold Sare_4246 68 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159036490 Common - Septum formation initiator Sare_0834 6 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 159040296 Nonpathogen - hypothetical protein Sare_4806 1 None None None 159039693 Common - ABC transporter related Sare_4166 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 159036848 Common - hypothetical protein Sare_1202 17 None None None 159040363 Common - ABC transporter related Sare_4875 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159039874 Common - hypothetical protein Sare_4355 8 None None None 159038466 Common - cobalamin synthesis CobW domain protein Sare_2902 65 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 159039302 Nonpathogen - hypothetical protein Sare_3771 1 None None None 159037120 Nonpathogen - hypothetical protein Sare_1484 1 None None None 159040067 Common - Phytanoyl-CoA dioxygenase Sare_4561 41 COG5285 COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin Secondary metabolites biosynthesis, transport, and catabolism 159040584 Common - parB-like partition protein Sare_5104 186 COG1475 Spo0J, Predicted transcriptional regulators Transcription 159036676 Common - pentapeptide repeat protein Sare_1028 30 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 159038127 Common - protein of unknown function DUF101 Sare_2547 2 COG1371 COG1371, Uncharacterized conserved protein Function unknown 159040514 Common - protein of unknown function DUF1025 Sare_5033 44 COG3824 COG3824, Uncharacterized protein conserved in bacteria Function unknown 159039593 Common - phospholipid/glycerol acyltransferase Sare_4065 39 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 159036741 Common - glycosyl transferase group 1 Sare_1095 100 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159038844 Common - Lysine exporter protein (LYSE/YGGA) Sare_3303 6 COG1279 COG1279, Lysine efflux permease General function prediction only 159036706 Common - MaoC domain protein dehydratase Sare_1059 37 COG2030 MaoC, Acyl dehydratase Lipid metabolism 159038041 Nonpathogen - hypothetical protein Sare_2457 1 None None None 159037874 Common - two component transcriptional regulator, winged helix family Sare_2277 226 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159040358 Nonpathogen - hypothetical protein Sare_4870 1 None None None 159035991 Common - helicase c2 Sare_0323 125 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 159037316 Common - UDP-glucose/GDP-mannose dehydrogenase Sare_1691 182 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 159039111 Nonpathogen - hypothetical protein Sare_3573 1 None None None 159037524 Nonpathogen - hypothetical protein Sare_1901 1 None None None 159040221 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Sare_4730 113 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 159037312 Common - glycosyl transferase group 1 Sare_1687 56 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159039309 Common - hypothetical protein Sare_3778 2 None None None 159038596 Common - transcriptional regulator, TetR family Sare_3036 34 COG1309 AcrR, Transcriptional regulator Transcription 159038578 Common - hypothetical protein Sare_3016 70 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 159037091 Common - deoxyxylulose-5-phosphate synthase Sare_1454 204 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 159037973 Common - acyl-CoA dehydrogenase domain protein Sare_2377 161 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159036588 Nonpathogen - hypothetical protein Sare_0935 1 None None None 159035870 Common - transcriptional regulator, AraC family Sare_0197 40 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 159036215 Common - Carboxymuconolactone decarboxylase Sare_0548 4 None None None 159036773 Nonpathogen - hypothetical protein Sare_1127 1 None None None 159035877 Common - VanW family protein Sare_0204 35 COG2720 COG2720, Uncharacterized vancomycin resistance protein Defense mechanisms 159036702 Common - fumarate lyase Sare_1055 193 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 159038756 Common - hypothetical protein Sare_3211 14 None None None 159036613 Nonpathogen - hypothetical protein Sare_0963 1 None None None 159037051 Nonpathogen - F45E12.5a-like protein Sare_1413 1 None None None 159039229 Nonpathogen - hypothetical protein Sare_3698 1 None None None 159037940 Common - Domain of unknown function DUF1801 Sare_2344 12 COG5646 COG5646, Uncharacterized conserved protein Function unknown 159036000 Common - phosphate ABC transporter, inner membrane subunit PstA Sare_0332 220 COG0581 PstA, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 159038530 Nonpathogen - hypothetical protein Sare_2966 1 None None None 159040570 Nonpathogen - hypothetical protein Sare_5090 2 None None None 159038882 Common - hypothetical protein Sare_3341 11 None None None 159038656 Nonpathogen - Fibronectin type III domain protein Sare_3110 4 None None None 159038537 Nonpathogen - hypothetical protein Sare_2974 1 None None None 159036623 Nonpathogen - GYD family protein Sare_0973 9 COG4274 COG4274, Uncharacterized conserved protein Function unknown 159036586 Nonpathogen - hypothetical protein Sare_0933 1 None None None 159039212 Nonpathogen - hypothetical protein Sare_3680 1 None None None 159036324 Common - MgtE intracellular region Sare_0664 165 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 159037229 Nonpathogen - hypothetical protein Sare_1598 1 None None None 159035823 Nonpathogen - hypothetical protein Sare_0150 1 None None None 159039889 Common - polymorphic outer membrane protein Sare_4370 39 None None None 159040096 Common - ABC transporter related Sare_4598 245 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 159035901 Nonpathogen - hypothetical protein Sare_0228 1 None None None 159039420 Common - hypothetical protein Sare_3891 16 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 159036394 Common - sulfate adenylyltransferase, small subunit Sare_0737 130 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 159037544 Common - small GTP-binding protein Sare_1921 218 COG1160 COG1160, Predicted GTPases General function prediction only 159037383 Common - MscS Mechanosensitive ion channel Sare_1758 46 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 159036710 Nonpathogen - hypothetical protein Sare_1063 1 None None None 159036497 Common - dienelactone hydrolase Sare_0841 83 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 159040224 Nonpathogen - hypothetical protein Sare_4733 1 None None None 159039276 Nonpathogen - hypothetical protein Sare_3745 1 None None None 159039405 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Sare_3875 204 COG0388 COG0388, Predicted amidohydrolase General function prediction only 159036107 Common - inositol monophosphatase Sare_0440 186 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 159035789 Nonpathogen - hypothetical protein Sare_0116 1 None None None 159039225 Nonpathogen - hypothetical protein Sare_3694 1 None None None 159038094 Common - Chorismate binding-like protein Sare_2513 220 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 159038748 Common - hypothetical protein Sare_3203 30 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 159039950 Nonpathogen - hypothetical protein Sare_4438 1 None None None 159038175 Nonpathogen - hypothetical protein Sare_2596 1 None None None 159037205 Nonpathogen - hypothetical protein Sare_1571 1 None None None 159039910 Nonpathogen - hypothetical protein Sare_4395 1 None None None 159039486 Common - NLP/P60 protein Sare_3958 109 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 159037642 Common - DegT/DnrJ/EryC1/StrS aminotransferase Sare_2034 192 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 159036047 Nonpathogen - hypothetical protein Sare_0380 1 None None None 159038781 Common - hypothetical protein Sare_3239 9 None None None 159039040 Nonpathogen - hypothetical protein Sare_3500 2 None None None 159036573 Common - cell division ATP-binding protein FtsE Sare_0918 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 159037195 Common - hypothetical protein Sare_1561 14 None None None 159037983 Common - hypothetical protein Sare_2387 20 None None None 159035712 Nonpathogen - hypothetical protein Sare_0038 1 None None None 159037460 Common - sodium/hydrogen exchanger Sare_1837 118 COG3263 COG3263, NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain Inorganic ion transport and metabolism 159037649 Common - ABC-2 type transporter Sare_2043 73 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 159038238 Common - cytochrome P450 Sare_2663 88 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159037349 Nonpathogen - hypothetical protein Sare_1724 1 None None None 159039460 Nonpathogen - hypothetical protein Sare_3931 1 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 159039848 Common - ribosomal protein L11 Sare_4329 246 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 159039427 Common - Endoribonuclease L-PSP Sare_3898 147 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 159039552 Common - modification methylase, HemK family Sare_4024 212 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 159038065 Common - glycerophosphoryl diester phosphodiesterase Sare_2484 165 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 159040327 Common - protein of unknown function DUF690 Sare_4839 6 None None None 159038185 Common - NUDIX hydrolase Sare_2607 3 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 159039941 Nonpathogen - hypothetical protein Sare_4426 1 None None None 159038101 Common - FHA domain containing protein Sare_2520 63 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 159039047 Nonpathogen - hypothetical protein Sare_3507 1 None None None 159039317 Common - pentapeptide repeat protein Sare_3786 55 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 159038051 Common - protein of unknown function DUF129 Sare_2468 27 COG1478 COG1478, Uncharacterized conserved protein Function unknown 159036076 Common - Proline dehydrogenase Sare_0409 126 COG0506 PutA, Proline dehydrogenase Amino acid transport and metabolism 159036808 Common - D-alanine--D-alanine ligase Sare_1162 213 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 159040228 Nonpathogen - hypothetical protein Sare_4737 1 None None None 159039724 Common - peptidase M23B Sare_4205 193 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 159037134 Nonpathogen - hypothetical protein Sare_1498 12 COG0433 COG0433, Predicted ATPase General function prediction only 159039342 Nonpathogen - hypothetical protein Sare_3811 1 None None None 159037012 Common - membrane-bound metal-dependent hydrolase Sare_1373 4 COG1988 COG1988, Predicted membrane-bound metal-dependent hydrolases General function prediction only 159038150 Common - bifunctional deaminase-reductase domain protein Sare_2570 192 COG1985 RibD, Pyrimidine reductase, riboflavin biosynthesis Coenzyme metabolism 159038076 Common - major facilitator superfamily MFS_1 Sare_2495 22 None None None 159038766 Common - cyclase family protein Sare_3221 35 COG1878 COG1878, Predicted metal-dependent hydrolase General function prediction only 159040236 Common - hypoxanthine phosphoribosyltransferase Sare_4745 146 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 159038204 Common - Methyltransferase type 11 Sare_2627 161 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159038350 Nonpathogen - hypothetical protein Sare_2777 2 COG5617 COG5617, Predicted integral membrane protein Function unknown 159040450 Nonpathogen - TadE family protein Sare_4966 4 COG4961 TadG, Flp pilus assembly protein TadG Intracellular trafficking and secretion 159038965 Common - hypothetical protein Sare_3425 14 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 159040247 Common - peptidase S1 and S6 chymotrypsin/Hap Sare_4756 197 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 159038633 Common - aminoglycoside phosphotransferase Sare_3081 5 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 159038279 Common - cobalamin biosynthesis protein CbiD Sare_2704 87 COG1903 CbiD, Cobalamin biosynthesis protein CbiD Coenzyme metabolism 159039367 Common - heat-inducible transcription repressor HrcA Sare_3836 151 COG1420 HrcA, Transcriptional regulator of heat shock gene Transcription 159036975 Common - tRNA pseudouridine synthase B Sare_1336 244 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 159039998 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Sare_4488 21 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 159039557 Common - homoserine kinase Sare_4029 103 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 159037280 Nonpathogen - hypothetical protein Sare_1652 1 None None None 159038976 Common - cell division protein FtsZ Sare_3436 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 159039831 Common - ribosomal protein L2 Sare_4312 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 159038373 Common - transcriptional regulator, TetR family Sare_2800 110 COG1309 AcrR, Transcriptional regulator Transcription 159040178 Common - hypothetical protein Sare_4687 11 None None None 159038539 Nonpathogen - hypothetical protein Sare_2976 1 None None None 159039955 Common - hypothetical protein Sare_4443 4 None None None 159037821 Common - protein of unknown function DUF81 Sare_2223 20 COG0730 COG0730, Predicted permeases General function prediction only 159040559 Common - hypothetical protein Sare_5079 9 None None None 159037482 Common - hypothetical protein Sare_1859 35 COG1102 Cmk, Cytidylate kinase Nucleotide transport and metabolism 159040242 Common - Inorganic diphosphatase Sare_4751 186 COG0221 Ppa, Inorganic pyrophosphatase Energy production and conversion 159037661 Nonpathogen - hypothetical protein Sare_2056 2 None None None 159037008 Common - protein of unknown function DUF21 Sare_1369 213 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 159040550 Common - apurinic endonuclease Apn1 Sare_5069 84 COG0648 Nfo, Endonuclease IV DNA replication, recombination, and repair 159038699 Common - Acyl transferase Sare_3153 210 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159037859 Common - Na+/H+ antiporter NhaA Sare_2262 106 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 159038741 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Sare_3196 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 159039570 Common - MMPL domain protein Sare_4042 39 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 159037487 Nonpathogen - hypothetical protein Sare_1864 2 None None None 159038837 Nonpathogen - hypothetical protein Sare_3296 1 None None None 159035722 Common - FHA domain containing protein Sare_0048 38 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 159039731 Common - binding-protein-dependent transport systems inner membrane component Sare_4212 215 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 159039914 Common - PSP1 domain protein Sare_4399 58 COG1774 COG1774, Uncharacterized homolog of PSP1 Function unknown 159039758 Common - ROK family protein Sare_4239 85 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 159036557 Common - mannose-6-phosphate isomerase, class I Sare_0902 41 COG1482 ManA, Phosphomannose isomerase Carbohydrate transport and metabolism 159036302 Common - Endopeptidase Clp Sare_0642 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 159037554 Nonpathogen - hypothetical protein Sare_1931 1 None None None 159036269 Nonpathogen - Lanthionine synthetase C family protein Sare_0603 7 None None None 159036408 Common - basic membrane lipoprotein Sare_0751 80 COG1744 Med, Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein General function prediction only 159037705 Common - cytochrome P450 Sare_2102 81 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159036876 Common - uridylate kinase Sare_1232 226 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 159036626 Common - TrkA-N domain protein Sare_0976 58 COG2910 COG2910, Putative NADH-flavin reductase General function prediction only 159040457 Common - hypothetical protein Sare_4973 5 None None None 159036421 Common - hypothetical protein Sare_0764 7 COG3898 COG3898, Uncharacterized membrane-bound protein Function unknown 159040346 Common - chitin-binding domain 3 protein Sare_4858 23 COG3397 COG3397, Uncharacterized protein conserved in bacteria Function unknown 159036231 Common - Phosphoribosylaminoimidazolecarboxamide formyltransferase Sare_0565 213 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 159036404 Common - extracellular solute-binding protein family 1 Sare_0747 120 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 159039038 Common - hypothetical protein Sare_3498 9 None None None 159039118 Common - glutamate-ammonia ligase adenylyltransferase Sare_3580 119 COG1391 GlnE, Glutamine synthetase adenylyltransferase Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms 159035793 Common - ATPase AAA-2 domain protein Sare_0120 220 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 159038518 Common - ABC-type branched-chain amino acid transport systems periplasmic component-like protein Sare_2954 50 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 159037499 Common - ribosomal protein L35 Sare_1876 75 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 159036989 Nonpathogen - hypothetical protein Sare_1350 2 None None None 159039452 Common - glycosyl transferase family 51 Sare_3923 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 159037700 Common - condensation domain protein Sare_2097 62 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159038576 Nonpathogen - nucleoside diphosphate kinase Sare_3014 1 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 159036966 Common - translation initiation factor IF-2 Sare_1327 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 159037910 Nonpathogen - hypothetical protein Sare_2314 2 None None None 159036434 Common - amidohydrolase Sare_0777 168 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 159038790 Common - HAD-superfamily hydrolase, subfamily IIA Sare_3248 112 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 159037560 Nonpathogen - molecular chaperone Sare_1937 3 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 159040199 Common - HhH-GPD family protein Sare_4708 214 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 159037431 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Sare_1807 98 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 159037919 Common - transcriptional regulator, GntR family Sare_2323 113 COG2188 PhnF, Transcriptional regulators Transcription 159039940 Common - PilT protein domain protein Sare_4425 16 COG1487 VapC, Predicted nucleic acid-binding protein, contains PIN domain General function prediction only 159038774 Common - UDP-N-acetylmuramoylalanine--D-glutamate ligase Sare_3229 207 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 159039584 Common - fatty acid desaturase Sare_4056 22 COG3239 DesA, Fatty acid desaturase Lipid metabolism 159037710 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_2107 17 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 159037323 Common - hypothetical protein Sare_1698 22 COG4850 COG4850, Uncharacterized conserved protein Function unknown 159039857 Common - cold-shock DNA-binding domain protein Sare_4338 157 COG1278 CspC, Cold shock proteins Transcription 159037289 Common - binding-protein-dependent transport systems inner membrane component Sare_1663 219 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 159039602 Common - Alcohol dehydrogenase zinc-binding domain protein Sare_4074 141 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 159039979 Common - Radical SAM domain protein Sare_4467 84 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 159040286 Common - transcription factor WhiB Sare_4795 19 None None None 159036447 Common - drug resistance transporter, EmrB/QacA subfamily Sare_0790 174 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159037375 Common - cytidyltransferase-related domain Sare_1750 118 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 159037035 Nonpathogen - hypothetical protein Sare_1397 3 None None None 159037593 Common - hypothetical protein Sare_1970 12 COG3236 COG3236, Uncharacterized protein conserved in bacteria Function unknown 159040273 Common - CutC family protein Sare_4782 58 COG3142 CutC, Uncharacterized protein involved in copper resistance Inorganic ion transport and metabolism 159035813 Common - phosphoribosylamine--glycine ligase Sare_0140 233 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 159039245 Common - phage-related major capsid protein Sare_3714 4 None None None 159038266 Common - transcriptional regulator, SARP family Sare_2691 7 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 159036060 Common - extracellular solute-binding protein family 1 Sare_0393 30 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 159037909 Common - peptidase M20 Sare_2313 188 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 159036391 Common - ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5 Sare_0734 148 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 159036475 Common - protein of unknown function DUF606 Sare_0819 11 COG3238 COG3238, Uncharacterized protein conserved in bacteria Function unknown 159038795 Common - protein of unknown function DUF58 Sare_3253 68 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 159036356 Common - putative sensor with HAMP domain Sare_0699 44 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 159038270 Common - Polymorphic membrane protein Chlamydia Sare_2695 21 None None None 159038915 Common - inner-membrane translocator Sare_3375 149 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 159037145 Common - acyl-CoA dehydrogenase domain protein Sare_1511 149 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159037900 Common - cell divisionFtsK/SpoIIIE Sare_2304 24 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 159040375 Common - Methyltransferase type 12 Sare_4888 47 COG5459 COG5459, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 159037342 Common - tRNA (guanine-N(7)-)-methyltransferase Sare_1717 169 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 159038476 Common - putative oxygenase subunit protein Sare_2912 19 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 159036636 Common - ATP-dependent Clp protease adaptor protein ClpS Sare_0987 18 COG2127 COG2127, Uncharacterized conserved protein Function unknown 159039100 Common - lipoate-protein ligase B Sare_3560 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 159039073 Common - Cysteine desulfurase Sare_3533 122 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 159036635 Common - putative nicotinate phosphoribosyltransferase Sare_0986 103 COG1488 PncB, Nicotinic acid phosphoribosyltransferase Coenzyme metabolism 159038058 Common - integrase family protein Sare_2477 183 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 159039359 Common - GTP-binding protein Era Sare_3828 220 COG1159 Era, GTPase General function prediction only 159038668 Common - Lysine exporter protein (LYSE/YGGA) Sare_3122 55 COG1279 COG1279, Lysine efflux permease General function prediction only 159038345 Nonpathogen - hypothetical protein Sare_2772 1 None None None 159036248 Common - SAICAR synthetase Sare_0582 127 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 159038440 Common - flavin reductase domain protein FMN-binding Sare_2876 114 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 159039862 Nonpathogen - peptidase M48 Ste24p Sare_4343 1 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 159038782 Common - glycosyl transferase family 51 Sare_3240 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 159035782 Common - Pyruvate dehydrogenase (acetyl-transferring) Sare_0109 154 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 159037438 Common - major facilitator superfamily MFS_1 Sare_1814 23 COG2271 UhpC, Sugar phosphate permease Carbohydrate transport and metabolism 159037026 Common - hypothetical protein Sare_1388 10 None None None 159039239 Nonpathogen - hypothetical protein Sare_3708 1 None None None 159039396 Common - isoleucyl-tRNA synthetase Sare_3866 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159036451 Common - maf protein Sare_0794 194 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 159036995 Common - CinA domain protein Sare_1356 191 COG1546 CinA, Uncharacterized protein (competence- and mitomycin-induced) General function prediction only 159037194 Common - sporulation and cell division protein SsgA Sare_1560 8 None None None 159039861 Nonpathogen - hypothetical protein Sare_4342 1 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 159039244 Nonpathogen - hypothetical protein Sare_3713 1 None None None 159039456 Common - hypothetical protein Sare_3927 16 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 159036058 Common - binding-protein-dependent transport systems inner membrane component Sare_0391 122 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 159040270 Common - binding-protein-dependent transport systems inner membrane component Sare_4779 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 159038524 Common - aminotransferase class-III Sare_2960 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 159037436 Common - aspartyl-tRNA synthetase Sare_1812 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159039744 Common - Peptidase M1 membrane alanine aminopeptidase Sare_4225 137 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 159038288 Common - fumarate reductase/succinate dehydrogenase flavoprotein domain protein Sare_2713 27 COG3573 COG3573, Predicted oxidoreductase General function prediction only 159038953 Common - imidazoleglycerol phosphate synthase, cyclase subunit Sare_3413 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 159039994 Nonpathogen - hypothetical protein Sare_4484 1 None None None 159040379 Common - hypothetical protein Sare_4892 4 None None None 159037470 Common - dihydroorotase, multifunctional complex type Sare_1847 212 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 159038323 Nonpathogen - hypothetical protein Sare_2750 18 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 159038207 Common - ABC transporter related Sare_2630 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 159039822 Common - ribosomal protein L5 Sare_4303 248 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 159040370 Common - protein of unknown function DUF574 Sare_4882 12 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 159036070 Common - histidine kinase Sare_0403 221 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 159038660 Common - transglutaminase domain protein Sare_3114 66 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 159039085 Common - cobalbumin biosynthesis protein Sare_3545 101 COG2087 CobU, Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase Coenzyme metabolism 159040098 Nonpathogen - hypothetical protein Sare_4601 1 None None None 159039340 Common - putative TIM-barrel protein, nifR3 family Sare_3809 207 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 159038978 Common - UDP-N-acetylmuramate--alanine ligase Sare_3438 211 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 159038671 Nonpathogen - hypothetical protein Sare_3125 1 None None None 159039829 Common - ribosomal protein L22 Sare_4310 219 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 159040203 Nonpathogen - hypothetical protein Sare_4712 1 None None None 159039682 Nonpathogen - hypothetical protein Sare_4154 4 None None None 159039905 Nonpathogen - hypothetical protein Sare_4389 1 None None None 159037759 Common - peptidase M20 Sare_2156 169 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 159037199 Common - diguanylate cyclase Sare_1565 155 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 159037913 Common - luciferase family protein Sare_2317 54 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 159036650 Common - transcriptional regulator, RpiR family Sare_1001 29 COG1737 RpiR, Transcriptional regulators Transcription 159038669 Common - transcriptional regulator, LysR family Sare_3123 117 COG0583 LysR, Transcriptional regulator Transcription 159038639 Common - helicase domain protein Sare_3088 129 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 159036444 Common - DoxX family protein Sare_0787 4 COG4270 COG4270, Predicted membrane protein Function unknown 159036152 Nonpathogen - protein of unknown function DUF201 Sare_0485 2 COG0439 AccC, Biotin carboxylase Lipid metabolism 159037694 Common - monooxygenase, FAD-binding Sare_2091 22 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 159038581 Nonpathogen - hypothetical protein Sare_3019 1 None None None 159039751 Common - chaperonin Cpn10 Sare_4232 216 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 159038210 Common - FAD dependent oxidoreductase Sare_2633 33 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 159039834 Common - ribosomal protein L3 Sare_4315 235 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 159037547 Common - hypothetical protein Sare_1924 14 None None None 159036431 Common - phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I Sare_0774 95 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 159037740 Nonpathogen - FAD dependent oxidoreductase Sare_2137 1 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 159036503 Nonpathogen - hypothetical protein Sare_0847 1 None None None 159040104 Common - transcriptional regulator, IclR family Sare_4608 110 COG1414 IclR, Transcriptional regulator Transcription 159040377 Common - amino acid adenylation domain Sare_4890 219 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159039856 Common - protein of unknown function DUF191 Sare_4337 35 COG2107 COG2107, Predicted periplasmic solute-binding protein General function prediction only 159039037 Common - Diphosphate--fructose-6-phosphate 1-phosphotransferase Sare_3497 161 COG0205 PfkA, 6-phosphofructokinase Carbohydrate transport and metabolism 159037995 Common - putative transcriptional regulator, TetR family Sare_2399 27 COG3226 COG3226, Uncharacterized protein conserved in bacteria Function unknown 159036437 Common - hypothetical protein Sare_0780 9 None None None 159036602 Nonpathogen - hypothetical protein Sare_0950 1 None None None 159040454 Common - type II secretion system protein E Sare_4970 151 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 159039328 Nonpathogen - hypothetical protein Sare_3797 1 COG1429 CobN, Cobalamin biosynthesis protein CobN and related Mg-chelatases Coenzyme metabolism 159036304 Common - TrkA-N domain protein Sare_0644 94 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 159040277 Nonpathogen - hypothetical protein Sare_4786 1 None None None 159036863 Nonpathogen - hypothetical protein Sare_1218 1 None None None 159040192 Common - hypothetical protein Sare_4701 5 None None None 159037097 Common - GCN5-related N-acetyltransferase Sare_1460 25 COG3393 COG3393, Predicted acetyltransferase General function prediction only 159039735 Common - phage shock protein C, PspC Sare_4216 15 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 159039265 Nonpathogen - hypothetical protein Sare_3734 1 None None None 159035888 Common - hypothetical protein Sare_0215 8 None None None 159037646 Common - extracellular solute-binding protein family 5 Sare_2038 67 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 159035798 Nonpathogen - hypothetical protein Sare_0125 2 None None None 159039633 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Sare_4105 6 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 159038449 Common - 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoAhydratase Sare_2885 28 COG2030 MaoC, Acyl dehydratase Lipid metabolism 159038010 Common - Serine-type D-Ala-D-Ala carboxypeptidase Sare_2416 121 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 159040158 Nonpathogen - hypothetical protein Sare_4667 2 None None None 159037953 Nonpathogen - hypothetical protein Sare_2357 8 COG1141 Fer, Ferredoxin Energy production and conversion 159038182 Nonpathogen - hypothetical protein Sare_2603 1 None None None 159038377 Common - coenzyme A transferase Sare_2804 55 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 159037024 Common - MMPL domain protein Sare_1386 40 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 159039028 Common - Substrate-binding region of ABC-type glycine betaine transport system Sare_3488 70 COG2113 ProX, ABC-type proline/glycine betaine transport systems, periplasmic components Amino acid transport and metabolism 159036913 Common - transcriptional regulator, LuxR family Sare_1270 28 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159038787 Common - protein of unknown function DUF107 Sare_3245 23 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 159040382 Common - amino acid adenylation domain Sare_4895 209 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159038083 Common - putative esterase Sare_2502 32 COG0627 COG0627, Predicted esterase General function prediction only 159036648 Common - amidase, hydantoinase/carbamoylase family Sare_0999 84 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 159037230 Nonpathogen - hypothetical protein Sare_1599 1 None None None 159040555 Common - hypothetical protein Sare_5074 15 COG5650 COG5650, Predicted integral membrane protein Function unknown 159038274 Common - uroporphyrin-III C-methyltransferase Sare_2699 187 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 159038617 Nonpathogen - hypothetical protein Sare_3060 1 None None None 159038705 Common - transcriptional regulator, SARP family Sare_3159 37 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 159036008 Common - Rhodanese domain protein Sare_0340 141 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 159036265 Common - protein of unknown function DUF397 Sare_0599 6 None None None 159038234 Nonpathogen - hypothetical protein Sare_2659 1 None None None 159038281 Common - precorrin-2 C20-methyltransferase Sare_2706 111 COG2243 CobF, Precorrin-2 methylase Coenzyme metabolism 159035742 Nonpathogen - hypothetical protein Sare_0068 1 None None None 159040516 Common - HAD-superfamily hydrolase, subfamily IIB Sare_5035 61 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 159039720 Nonpathogen - hypothetical protein Sare_4201 1 None None None 159036106 Common - low temperature requirement A Sare_0439 15 COG4292 COG4292, Predicted membrane protein Function unknown 159035893 Common - histidine kinase Sare_0220 200 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159035736 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Sare_0062 5 None None None 159037823 Common - beta-lactamase domain protein Sare_2225 109 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 159040245 Common - peptidase S8 and S53 subtilisin kexin sedolisin Sare_4754 122 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 159037659 Common - UBA/THIF-type NAD/FAD binding protein Sare_2054 69 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 159037709 Nonpathogen - hypothetical protein Sare_2106 1 None None None 159038745 Common - Haloacid dehalogenase domain protein hydrolase Sare_3200 25 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 159037854 Common - protein of unknown function DUF323 Sare_2257 112 COG1262 COG1262, Uncharacterized conserved protein Function unknown 159040231 Nonpathogen - hypothetical protein Sare_4740 1 None None None 159040582 Common - D-alanine--D-alanine ligase Sare_5102 213 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 159036091 Common - histidine kinase Sare_0424 133 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 159036976 Common - riboflavin biosynthesis protein RibF Sare_1337 210 COG0196 RibF, FAD synthase Coenzyme metabolism 159037483 Common - cytochrome P450 Sare_1860 63 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159039946 Common - acetate--CoA ligase Sare_4434 213 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 159040091 Common - short-chain dehydrogenase/reductase SDR Sare_4589 236 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 159036430 Common - uracil phosphoribosyltransferase Sare_0773 164 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 159037044 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) Sare_1406 194 COG0281 SfcA, Malic enzyme Energy production and conversion 159036659 Common - DSBA oxidoreductase Sare_1010 32 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 159040171 Common - 4-hydroxyphenylpyruvate dioxygenase Sare_4680 78 COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins Amino acid transport and metabolism / General function prediction only 159036942 Common - peptidase M50 Sare_1303 208 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 159040362 Common - ABC-2 type transporter Sare_4874 41 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 159039356 Common - undecaprenyl diphosphate synthase Sare_3825 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 159038769 Common - Substrate-binding region of ABC-type glycine betaine transport system Sare_3224 29 COG2113 ProX, ABC-type proline/glycine betaine transport systems, periplasmic components Amino acid transport and metabolism 159039975 Common - NADH-ubiquinone/plastoquinone oxidoreductase chain 3 Sare_4463 163 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 159038219 Common - hypothetical protein Sare_2644 4 None None None 159039319 Nonpathogen - hypothetical protein Sare_3788 1 None None None 159039292 Nonpathogen - hypothetical protein Sare_3761 1 None None None 159038853 Common - cytochrome oxidase assembly Sare_3312 29 COG1612 CtaA, Uncharacterized protein required for cytochrome oxidase assembly Posttranslational modification, protein turnover, chaperones 159036632 Common - Cytochrome c oxidase subunit I type Sare_0983 171 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 159036012 Common - transcriptional regulator, GntR family Sare_0344 67 COG2188 PhnF, Transcriptional regulators Transcription 159036572 Common - peptide chain release factor 2 Sare_0917 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 159037257 Common - binding-protein-dependent transport systems inner membrane component Sare_1627 152 COG4176 ProW, ABC-type proline/glycine betaine transport system, permease component Amino acid transport and metabolism 159038872 Nonpathogen - hypothetical protein Sare_3331 1 None None None 159038692 Common - AMP-dependent synthetase and ligase Sare_3146 222 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159040349 Common - histidine kinase Sare_4861 27 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 159040389 Common - cytochrome P450 Sare_4902 65 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159036841 Common - hypothetical protein Sare_1195 19 COG1837 COG1837, Predicted RNA-binding protein (contains KH domain) General function prediction only 159039275 Nonpathogen - hypothetical protein Sare_3744 1 None None None 159036399 Common - Phosphoesterase HXTX Sare_0742 12 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 159036892 Common - Beta-ketoacyl synthase Sare_1249 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159036986 Common - dihydrodipicolinate synthase Sare_1347 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 159037192 Common - transcriptional regulator, AraC family Sare_1558 60 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 159039107 Nonpathogen - RDD domain containing protein Sare_3567 1 None None None 159036687 Common - AMP-dependent synthetase and ligase Sare_1040 214 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 159038778 Nonpathogen - hypothetical protein Sare_3235 2 None None None 159039134 Common - hypothetical protein Sare_3598 102 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 159037150 Common - aldehyde dehydrogenase Sare_1516 213 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 159036610 Common - GCN5-related N-acetyltransferase Sare_0960 62 COG3053 CitC, Citrate lyase synthetase Energy production and conversion 159036766 Common - polymorphic outer membrane protein Sare_1120 20 None None None 159039560 Common - threonine synthase Sare_4032 173 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 159039216 Common - hypothetical protein Sare_3685 3 None None None 159036609 Common - major facilitator superfamily MFS_1 Sare_0959 6 None None None 159038901 Common - beta-lactamase Sare_3361 20 COG2367 PenP, Beta-lactamase class A Defense mechanisms 159037906 Common - hypothetical protein Sare_2310 7 None None None 159039915 Nonpathogen - hypothetical protein Sare_4400 1 None None None 159036667 Nonpathogen - hypothetical protein Sare_1018 1 None None None 159039041 Common - Alpha,alpha-trehalose-phosphate synthase (UDP-forming) Sare_3501 97 COG0380 OtsA, Trehalose-6-phosphate synthase Carbohydrate transport and metabolism 159038176 Common - major facilitator superfamily MFS_1 Sare_2597 175 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159039071 Common - Cytochrome-c oxidase Sare_3531 18 None None None 159038153 Common - CRISPR-associated protein, Cse1 family Sare_2573 14 None None None 159039764 Common - protein of unknown function UPF0079 Sare_4245 17 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 159036351 Common - molybdenum cofactor synthesis domain Sare_0693 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 159038070 Common - 3-dehydroquinate synthase Sare_2489 204 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 159035969 Nonpathogen - hypothetical protein Sare_0301 1 None None None 159040222 Common - dihydroneopterin aldolase Sare_4731 114 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 159036353 Nonpathogen - hypothetical protein Sare_0695 1 None None None 159038808 Common - Tetratricopeptide TPR_4 Sare_3267 19 COG4995 COG4995, Uncharacterized protein conserved in bacteria Function unknown 159035828 Common - protein of unknown function DUF74 Sare_0155 50 COG0393 COG0393, Uncharacterized conserved protein Function unknown 159037011 Common - major facilitator superfamily MFS_1 Sare_1372 207 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159036709 Nonpathogen - hypothetical protein Sare_1062 1 None None None 159038435 Nonpathogen - hypothetical protein Sare_2870 1 None None None 159036261 Common - hypothetical protein Sare_0595 4 None None None 159039499 Common - major facilitator superfamily MFS_1 Sare_3971 17 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159039473 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Sare_3945 10 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 159040365 Common - ribonucleoside-diphosphate reductase, alpha subunit Sare_4877 222 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 159036141 Common - peptidase M48 Ste24p Sare_0474 189 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 159037566 Nonpathogen - hypothetical protein Sare_1943 1 None None None 159036019 Common - transcriptional regulator, LuxR family Sare_0351 35 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159036732 Common - LPXTG-motif cell wall anchor domain Sare_1086 42 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 159036935 Common - Clp domain protein Sare_1294 73 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 159037871 Nonpathogen - hypothetical protein Sare_2274 1 None None None 159039712 Common - transcriptional regulator, SARP family Sare_4191 27 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 159037979 Common - Amidohydrolase 3 Sare_2383 61 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 159038484 Common - aminotransferase class I and II Sare_2920 153 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 159037003 Common - protein of unknown function DUF62 Sare_1364 71 COG1912 COG1912, Uncharacterized conserved protein Function unknown 159036464 Common - Phosphoenolpyruvate carboxykinase (GTP) Sare_0807 59 COG1274 PckA, Phosphoenolpyruvate carboxykinase (GTP) Energy production and conversion 159035806 Nonpathogen - hypothetical protein Sare_0133 1 None None None 159036705 Common - 3-Oxoacyl-(acyl-carrier-protein (ACP)) synthase III Sare_1058 3 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 159036589 Common - hypothetical protein Sare_0936 4 COG3889 COG3889, Predicted solute binding protein General function prediction only 159038361 Common - Dyp-type peroxidase family Sare_2788 38 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 159037146 Common - aminoglycoside phosphotransferase Sare_1512 59 COG3173 COG3173, Predicted aminoglycoside phosphotransferase General function prediction only 159036290 Common - UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase-like protein Sare_0629 28 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 159035869 Nonpathogen - Carboxymuconolactone decarboxylase Sare_0196 6 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 159040547 Common - ribosomal protein S18 Sare_5066 215 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 159037172 Common - regulator of chromosome condensation RCC1 Sare_1538 28 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 159036865 Common - hypothetical protein Sare_1220 3 None None None 159036905 Common - conserved polyketide synthase associated protein PapA5 Sare_1262 3 None None None 159039661 Common - hypothetical protein Sare_4133 130 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 159039847 Common - ribosomal protein L1 Sare_4328 233 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 159040160 Common - SNARE associated Golgi protein Sare_4669 76 COG0398 COG0398, Uncharacterized conserved protein Function unknown 159037579 Common - Phosphoenolpyruvate phosphomutase Sare_1956 86 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 159037449 Nonpathogen - lipopolysaccharide biosynthesis protein Sare_1825 1 COG3944 COG3944, Capsular polysaccharide biosynthesis protein Cell envelope biogenesis, outer membrane 159036452 Common - peptidase S8 and S53 subtilisin kexin sedolisin Sare_0795 98 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 159039056 Nonpathogen - hypothetical protein Sare_3516 1 None None None 159039148 Common - protein of unknown function UPF0047 Sare_3612 36 COG0432 COG0432, Uncharacterized conserved protein Function unknown 159036254 Common - ATP phosphoribosyltransferase Sare_0588 212 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 159037496 Common - ATP phosphoribosyltransferase Sare_1873 213 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 159036742 Nonpathogen - hypothetical protein Sare_1096 1 None None None 159039640 Common - hypothetical protein Sare_4112 24 COG5282 COG5282, Uncharacterized conserved protein Function unknown 159035862 Nonpathogen - hypothetical protein Sare_0189 1 None None None 159038095 Nonpathogen - hypothetical protein Sare_2514 3 None None None 159039690 Common - transcriptional regulator, AraC family Sare_4163 116 COG2169 Ada, Adenosine deaminase Nucleotide transport and metabolism 159036851 Common - Activator of Hsp90 ATPase 1 family protein Sare_1205 31 COG3832 COG3832, Uncharacterized conserved protein Function unknown 159038225 Common - Tetratricopeptide TPR_4 Sare_2650 40 COG2909 MalT, ATP-dependent transcriptional regulator Transcription 159040352 Common - pentapeptide repeat protein Sare_4864 73 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 159038043 Nonpathogen - restriction endonuclease Sare_2459 3 None None None 159038161 Common - IstB domain protein ATP-binding protein Sare_2581 97 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 159035873 Common - protein of unknown function DUF182 Sare_0200 108 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 159035778 Common - hypothetical protein Sare_0105 13 COG5373 COG5373, Predicted membrane protein Function unknown 159040064 Common - transposase IS4 family protein Sare_4558 4 None None None 159039771 Common - phosphoglucosamine mutase Sare_4252 240 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 159036242 Common - FAD dependent oxidoreductase Sare_0576 75 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 159036329 Common - Citryl-CoA lyase Sare_0669 117 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 159036620 Common - Antibiotic biosynthesis monooxygenase Sare_0970 5 COG1359 COG1359, Uncharacterized conserved protein Function unknown 159037419 Common - inner-membrane translocator Sare_1795 107 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 159036028 Nonpathogen - hypothetical protein Sare_0361 1 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 159037747 Common - phosphoribosylglycinamide synthetase Sare_2144 102 COG0439 AccC, Biotin carboxylase Lipid metabolism 159039331 Common - ABC transporter related Sare_3800 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159038987 Common - MraZ protein Sare_3447 138 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 159040003 Common - hypothetical protein Sare_4493 8 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 159036950 Common - transcriptional regulator, MerR family Sare_1311 66 COG0789 SoxR, Predicted transcriptional regulators Transcription 159039492 Common - metallophosphoesterase Sare_3964 14 COG2129 COG2129, Predicted phosphoesterases, related to the Icc protein General function prediction only 159035942 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Sare_0273 94 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 159035946 Common - amino acid permease-associated region Sare_0277 21 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 159039256 Common - phage-related hypothetical protein Sare_3725 4 None None None 159036917 Common - Shikimate dehydrogenase substrate binding domain protein Sare_1274 111 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 159037753 Common - Cupin 2 conserved barrel domain protein Sare_2150 9 COG2140 COG2140, Thermophilic glucose-6-phosphate isomerase and related metalloenzymes Carbohydrate transport and metabolism / General function prediction only 159040031 Common - anti-sigma-factor antagonist Sare_4521 27 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 159038351 Common - glycosyl transferase family 2 Sare_2778 201 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 159037260 Common - transcriptional regulator, MerR family Sare_1630 131 COG0789 SoxR, Predicted transcriptional regulators Transcription 159036775 Common - 3-isopropylmalate dehydrogenase Sare_1129 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 159038485 Common - HpcH/HpaI aldolase Sare_2921 109 COG2301 CitE, Citrate lyase beta subunit Carbohydrate transport and metabolism 159038887 Nonpathogen - hypothetical protein Sare_3346 1 None None None 159038759 Common - methylmalonate-semialdehyde dehydrogenase Sare_3214 219 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 159039668 Common - aminotransferase class I and II Sare_4140 235 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 159038107 Common - UspA domain protein Sare_2526 24 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 159036492 Common - GCN5-related N-acetyltransferase Sare_0836 50 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 159038750 Common - binding-protein-dependent transport systems inner membrane component Sare_3205 162 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 159038762 Common - short-chain dehydrogenase/reductase SDR Sare_3217 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159037328 Common - RNA binding S1 domain protein Sare_1703 139 COG2183 Tex, Transcriptional accessory protein Transcription 159040321 Common - hypothetical protein Sare_4833 3 COG4842 COG4842, Uncharacterized protein conserved in bacteria Function unknown 159040443 Common - major facilitator superfamily MFS_1 Sare_4959 29 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 159039923 Common - DNA topoisomerase I Sare_4408 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 159038046 Nonpathogen - hypothetical protein Sare_2463 1 None None None 159040329 Common - AAA ATPase central domain protein Sare_4841 75 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 159038015 Common - transcriptional regulator, MerR family Sare_2421 22 COG0789 SoxR, Predicted transcriptional regulators Transcription 159040075 Common - 4-oxalocrotonate decarboxylase Sare_4569 60 COG3971 COG3971, 2-keto-4-pentenoate hydratase Secondary metabolites biosynthesis, transport, and catabolism 159035995 Common - oxidoreductase domain protein Sare_0327 155 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 159040202 Common - lysyl-tRNA synthetase Sare_4711 249 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 159036970 Nonpathogen - hypothetical protein Sare_1331 1 None None None 159039767 Common - carbohydrate kinase, YjeF related protein Sare_4248 31 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 159039196 Common - hypothetical protein Sare_3661 6 None None None 159039687 Common - GTP-binding protein YchF Sare_4160 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 159039603 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) Sare_4075 190 COG0281 SfcA, Malic enzyme Energy production and conversion 159036831 Common - signal recognition particle-docking protein FtsY Sare_1185 246 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 159040572 Common - polynucleotide adenylyltransferase/metal dependent phosphohydrolase Sare_5092 206 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 159037237 Nonpathogen - hypothetical protein Sare_1606 1 None None None 159036782 Common - hypothetical protein Sare_1136 82 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 159036320 Nonpathogen - hypothetical protein Sare_0660 4 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 159035923 Nonpathogen - hypothetical protein Sare_0253 1 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 159038934 Common - prolipoprotein diacylglyceryl transferase Sare_3394 167 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 159040317 Nonpathogen - hypothetical protein Sare_4829 6 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 159040113 Nonpathogen - OsmC family protein Sare_4617 29 COG1765 COG1765, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 159035764 Common - hypothetical protein Sare_0091 7 None None None 159040439 Common - O-methyltransferase family 2 Sare_4955 36 None None None 159039030 Common - PfkB domain protein Sare_3490 97 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 159036392 Common - Aminoacyl-tRNA hydrolase Sare_0735 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 159038122 Common - major facilitator superfamily MFS_1 Sare_2542 205 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159036561 Common - hypothetical protein Sare_0906 13 None None None 159039383 Common - Phosphoglycerate mutase Sare_3852 135 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 159036217 Common - protein of unknown function DUF1702 Sare_0550 3 None None None 159035977 Common - GCN5-related N-acetyltransferase Sare_0309 13 COG0456 RimI, Acetyltransferases General function prediction only 159037764 Common - monooxygenase FAD-binding Sare_2162 106 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 159038940 Common - anthranilate synthase component I Sare_3400 221 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 159040168 Common - major facilitator superfamily MFS_1 Sare_4677 4 None None None 159040432 Common - short-chain dehydrogenase/reductase SDR Sare_4948 228 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 159039799 Nonpathogen - thiamine-phosphate pyrophosphorylase Sare_4280 4 COG0352 ThiE, Thiamine monophosphate synthase Coenzyme metabolism 159039725 Common - peptidase M23B Sare_4206 190 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 159036582 Nonpathogen - hypothetical protein Sare_0929 1 None None None 159038719 Common - GCN5-related N-acetyltransferase Sare_3174 37 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 159040046 Common - Methyltransferase type 12 Sare_4536 34 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159038380 Common - acetyl-CoA acetyltransferase Sare_2807 180 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 159038679 Common - hypothetical protein Sare_3133 4 None None None 159039860 Common - helicase domain protein Sare_4341 80 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 159039280 Nonpathogen - hypothetical protein Sare_3749 1 None None None 159036739 Common - ABC transporter related Sare_1093 249 COG1119 ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA Inorganic ion transport and metabolism 159037887 Nonpathogen - hypothetical protein Sare_2291 1 None None None 159037104 Common - 3-hydroxyacyl-CoA dehydrogenase NAD-binding Sare_1468 161 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 159039141 Common - polysaccharide pyruvyl transferase Sare_3605 34 COG2327 WcaK, Uncharacterized conserved protein Function unknown 159040080 Common - PEP-utilising protein mobile region Sare_4575 132 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 159040427 Common - DGPFAETKE family protein Sare_4943 43 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 159035832 Common - phosphoribosylformylglycinamidine synthase II Sare_0159 233 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 159036159 Common - 4'-phosphopantetheinyl transferase Sare_0492 43 COG2091 Sfp, Phosphopantetheinyl transferase Coenzyme metabolism 159035721 Common - FHA domain containing protein Sare_0047 61 COG1716 COG1716, FOG: FHA domain Signal transduction mechanisms 159040087 Common - hypothetical protein Sare_4583 6 None None None 159038864 Common - Triose-phosphate isomerase Sare_3323 217 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 159037466 Common - NusB antitermination factor Sare_1843 157 COG0781 NusB, Transcription termination factor Transcription 159036968 Common - ribosome-binding factor A Sare_1329 159 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 159036317 Common - Leucyl aminopeptidase Sare_0657 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 159038006 Common - Cupin 2 conserved barrel domain protein Sare_2411 24 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 159040467 Common - Transketolase central region Sare_4986 66 COG3958 COG3958, Transketolase, C-terminal subunit Carbohydrate transport and metabolism 159036737 Nonpathogen - glycoside hydrolase, family 3 domain protein Sare_1091 2 None None None 159038406 Common - short-chain dehydrogenase/reductase SDR Sare_2833 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159035963 Common - Methyltransferase type 11 Sare_0294 70 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159038330 Common - acyltransferase 3 Sare_2757 23 None None None 159038583 Nonpathogen - hypothetical protein Sare_3022 1 None None None 159040403 Common - RimK domain protein ATP-grasp Sare_4917 22 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 159039953 Common - protein of unknown function DUF909 Sare_4441 9 COG4842 COG4842, Uncharacterized protein conserved in bacteria Function unknown 159039790 Common - luciferase family protein Sare_4271 74 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 159037939 Common - drug resistance transporter, EmrB/QacA subfamily Sare_2343 169 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159039137 Nonpathogen - hypothetical protein Sare_3601 1 None None None 159036171 Common - Xanthine/uracil/vitamin C permease Sare_0504 135 COG2252 COG2252, Permeases General function prediction only 159037389 Common - aldo/keto reductase Sare_1764 178 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 159040408 Common - YcfA family protein Sare_4922 25 COG1724 COG1724, Predicted periplasmic or secreted lipoprotein Cell motility and secretion 159036747 Common - hypothetical protein Sare_1101 11 None None None 159036373 Common - Enoyl-CoA hydratase/isomerase Sare_0716 177 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 159040502 Common - cell envelope-related transcriptional attenuator Sare_5021 63 COG1316 LytR, Transcriptional regulator Transcription 159037444 Common - Holliday junction resolvase YqgF Sare_1820 27 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 159039657 Nonpathogen - hypothetical protein Sare_4129 1 None None None 159037869 Nonpathogen - hypothetical protein Sare_2272 2 None None None 159037033 Common - ABC transporter related Sare_1395 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 159036296 Common - short-chain dehydrogenase/reductase SDR Sare_0635 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159036483 Common - protein of unknown function DUF195 Sare_0827 93 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 159040107 Common - FAD dependent oxidoreductase Sare_4611 150 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 159039810 Common - translation initiation factor IF-1 Sare_4291 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 159036139 Common - proton-translocating NADH-quinone oxidoreductase, chain M Sare_0472 203 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 159038392 Common - hypothetical protein Sare_2819 87 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 159037617 Common - hypothetical protein Sare_2003 3 None None None 159040565 Nonpathogen - hypothetical protein Sare_5085 1 None None None 159039006 Common - DNA polymerase III, alpha subunit Sare_3466 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 159039451 Common - aminotransferase class I and II Sare_3922 136 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 159037928 Common - Methyltransferase type 11 Sare_2332 205 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159037623 Common - hypothetical protein Sare_2009 4 None None None 159036777 Common - protein tyrosine/serine phosphatase Sare_1131 50 COG2365 COG2365, Protein tyrosine/serine phosphatase Signal transduction mechanisms 159040419 Common - Tetratricopeptide TPR_4 Sare_4935 59 COG3899 COG3899, Predicted ATPase General function prediction only 159039481 Common - protein of unknown function DUF1360 Sare_3953 7 None None None 159038561 Common - extracellular solute-binding protein family 1 Sare_2999 77 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 159037967 Common - Sec-independent protein translocase, TatC subunit Sare_2371 202 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 159040489 Common - two component transcriptional regulator, LytTR family Sare_5008 164 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 159038260 Common - Cupin 2 conserved barrel domain protein Sare_2685 16 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 159039437 Nonpathogen - hypothetical protein Sare_3908 1 None None None 159037912 Common - aldo/keto reductase Sare_2316 201 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 159038148 Common - amidohydrolase Sare_2568 149 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 159036793 Common - 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase Sare_1147 179 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 159036085 Common - HAD-superfamily subfamily IB hydrolase, TIGR01490 Sare_0418 112 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 159038902 Common - protein tyrosine/serine phosphatase Sare_3362 49 COG2365 COG2365, Protein tyrosine/serine phosphatase Signal transduction mechanisms 159038111 Nonpathogen - hypothetical protein Sare_2530 1 None None None 159039386 Common - protein of unknown function DUF397 Sare_3856 6 None None None 159036195 Common - hypothetical protein Sare_0528 2 None None None 159039972 Common - NADH dehydrogenase I, D subunit Sare_4460 191 COG0649 NuoD, NADH:ubiquinone oxidoreductase 49 kD subunit 7 Energy production and conversion 159039001 Common - hypothetical protein Sare_3461 7 None None None 159039530 Common - protein of unknown function DUF91 Sare_4002 37 COG1637 COG1637, Predicted nuclease of the RecB family DNA replication, recombination, and repair 159037907 Nonpathogen - hypothetical protein Sare_2311 1 None None None 159037339 Nonpathogen - hypothetical protein Sare_1714 1 None None None 159037783 Common - protein of unknown function DUF899 thioredoxin family protein Sare_2183 27 COG4312 COG4312, Uncharacterized protein conserved in bacteria Function unknown 159040416 Common - Squalene/phytoene synthase Sare_4931 108 COG1562 ERG9, Phytoene/squalene synthetase Lipid metabolism 159038724 Common - hypothetical protein Sare_3179 17 None None None 159035979 Common - chaperonin GroEL Sare_0311 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 159038717 Nonpathogen - hypothetical protein Sare_3172 3 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 159038942 Common - ABC transporter related Sare_3402 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159039375 Common - ribosomal protein S20 Sare_3844 207 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 159038192 Common - cobalamin synthesis protein P47K Sare_2614 129 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 159038653 Common - transposase IS4 family protein Sare_3105 7 None None None 159038952 Nonpathogen - hypothetical protein Sare_3412 1 None None None 159035912 Common - Activator of Hsp90 ATPase 1 family protein Sare_0240 7 COG3832 COG3832, Uncharacterized conserved protein Function unknown 159035680 Nonpathogen - hypothetical protein Sare_0006 1 None None None 159036678 Common - hypothetical protein Sare_1031 5 None None None 159038548 Nonpathogen - hypothetical protein Sare_2986 1 None None None 159037062 Common - RNA polymerase, sigma 70 subunit, RpoD family Sare_1424 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 159040183 Common - transcriptional regulator, CarD family Sare_4692 82 COG1329 COG1329, Transcriptional regulators, similar to M. xanthus CarD Transcription 159036826 Nonpathogen - hypothetical protein Sare_1180 1 None None None 159037177 Nonpathogen - hypothetical protein Sare_1543 1 None None None 159039102 Nonpathogen - hypothetical protein Sare_3562 1 None None None 159037600 Common - CRISPR-associated protein Cas1 Sare_1977 56 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 159039129 Nonpathogen - hypothetical protein Sare_3592 1 None None None 159037292 Common - cation efflux protein Sare_1666 13 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 159037278 Common - transposase IS4 family protein Sare_1650 33 COG5659 COG5659, FOG: Transposase DNA replication, recombination, and repair 159039179 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_3643 2 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 159038980 Common - cell cycle protein Sare_3440 192 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 159039446 Common - ABC transporter related Sare_3917 246 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 159036770 Common - acetolactate synthase, small subunit Sare_1124 194 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 159035987 Common - membrane protein-like protein Sare_0319 27 COG2339 COG2339, Predicted membrane protein Function unknown 159036068 Common - major facilitator superfamily MFS_1 Sare_0401 29 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159036789 Nonpathogen - hypothetical protein Sare_1143 3 None None None 159040284 Common - Anion-transporting ATPase Sare_4793 14 COG0003 ArsA, Predicted ATPase involved in chromosome partitioning Cell division and chromosome partitioning 159037074 Common - hypothetical protein Sare_1437 19 None None None 159036228 Nonpathogen - hypothetical protein Sare_0562 1 None None None 159039526 Common - hypothetical protein Sare_3998 57 COG2945 COG2945, Predicted hydrolase of the alpha/beta superfamily General function prediction only 159040574 Common - serine/threonine protein kinase Sare_5094 50 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 159035819 Common - MaoC domain protein dehydratase Sare_0146 27 COG2030 MaoC, Acyl dehydratase Lipid metabolism 159037426 Common - protein-export membrane protein SecD Sare_1802 207 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 159037867 Common - hypothetical protein Sare_2270 4 None None None 159037876 Common - glycosyl transferase family 39 Sare_2279 17 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 159038269 Nonpathogen - hypothetical protein Sare_2694 1 COG3743 COG3743, Uncharacterized conserved protein Function unknown 159038156 Common - CRISPR-associated protein Cas5 family Sare_2576 41 None None None 159039679 Common - succinate dehydrogenase and fumarate reductase iron-sulfur protein Sare_4151 206 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 159035985 Common - membrane protein-like protein Sare_0317 18 COG4129 COG4129, Predicted membrane protein Function unknown 159038408 Common - 2-nitropropane dioxygenase NPD Sare_2835 125 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 159039206 Nonpathogen - hypothetical protein Sare_3673 1 None None None 159035852 Common - alpha/beta hydrolase fold-1 Sare_0179 15 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159037058 Common - transcriptional regulator, LysR family Sare_1420 119 COG0583 LysR, Transcriptional regulator Transcription 159038059 Common - ABC transporter related Sare_2478 244 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 159038809 Common - NADPH-dependent FMN reductase Sare_3268 23 COG0431 COG0431, Predicted flavoprotein General function prediction only 159040233 Nonpathogen - hypothetical protein Sare_4742 1 None None None 159038818 Common - FAD dependent oxidoreductase Sare_3277 136 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 159036143 Common - short-chain dehydrogenase/reductase SDR Sare_0476 128 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 159037200 Nonpathogen - hypothetical protein Sare_1566 1 None None None 159038151 Common - CMP/dCMP deaminase zinc-binding Sare_2571 168 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 159035733 Common - protein of unknown function DUF224 cysteine-rich region domain protein Sare_0059 105 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 159039623 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sare_4095 174 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159037207 Common - Haloacid dehalogenase domain protein hydrolase Sare_1573 29 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 159039932 Nonpathogen - hypothetical protein Sare_4417 1 None None None 159035719 Common - glycosyl transferase, WecB/TagA/CpsF family Sare_0045 109 COG1922 WecG, Teichoic acid biosynthesis proteins Cell envelope biogenesis, outer membrane 159036295 Common - NmrA family protein Sare_0634 100 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 159036712 Common - Beta-ketoacyl synthase Sare_1065 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159039709 Nonpathogen - hypothetical protein Sare_4185 1 None None None 159037890 Common - anti-sigma-factor antagonist Sare_2294 210 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 159037402 Common - pyridoxine biosynthesis protein Sare_1777 87 COG0214 SNZ1, Pyridoxine biosynthesis enzyme Coenzyme metabolism 159035750 Common - alpha/beta hydrolase fold Sare_0077 38 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159037455 Common - Glycosyltransferase 28 domain Sare_1831 9 COG5017 COG5017, Uncharacterized conserved protein Function unknown 159037286 Common - glucose-6-phosphate dehydrogenase Sare_1660 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 159040495 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sare_5014 64 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159037884 Common - hypothetical protein Sare_2288 18 COG3591 COG3591, V8-like Glu-specific endopeptidase Amino acid transport and metabolism 159039545 Common - H+transporting two-sector ATPase C subunit Sare_4017 43 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 159039432 Common - aldehyde dehydrogenase Sare_3903 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 159037542 Common - pseudouridine synthase Sare_1919 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 159038585 Nonpathogen - hypothetical protein Sare_3025 3 COG2026 RelE, Cytotoxic translational repressor of toxin-antitoxin stability system Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning 159039700 Common - isocitrate dehydrogenase, NADP-dependent Sare_4173 62 COG0538 Icd, Isocitrate dehydrogenases Energy production and conversion 159038146 Common - hypothetical protein Sare_2566 54 COG2323 COG2323, Predicted membrane protein Function unknown 159039417 Nonpathogen - hypothetical protein Sare_3888 1 None None None 159036330 Nonpathogen - hypothetical protein Sare_0670 1 None None None 159037536 Common - TM2 domain containing protein? Sare_1913 10 COG2314 XynA, Predicted membrane protein Function unknown 159040265 Common - hypothetical protein Sare_4774 18 None None None 159039115 Common - hypothetical protein Sare_3577 13 None None None 159037385 Nonpathogen - hypothetical protein Sare_1760 1 None None None 159038622 Common - major facilitator superfamily MFS_1 Sare_3065 2 None None None 159038949 Common - low temperature requirement A Sare_3409 11 COG4292 COG4292, Predicted membrane protein Function unknown 159040148 Common - ABC transporter related Sare_4657 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 159037083 Common - deoxyuridine 5'-triphosphate nucleotidohydrolase Dut Sare_1446 171 COG0756 Dut, dUTPase Nucleotide transport and metabolism 159036090 Common - two component transcriptional regulator, LuxR family Sare_0423 153 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159037170 Common - hypothetical protein Sare_1536 24 COG4832 COG4832, Uncharacterized conserved protein Function unknown 159039566 Common - hypothetical protein Sare_4038 12 None None None 159037269 Common - Dynamin family protein Sare_1639 34 COG1160 COG1160, Predicted GTPases General function prediction only 159036512 Common - GCN5-related N-acetyltransferase Sare_0856 48 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 159036820 Common - protein of unknown function DUF177 Sare_1174 54 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 159037409 Common - DNA polymerase III, alpha subunit Sare_1784 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 159037597 Common - CRISPR-associated protein, Cse4 family Sare_1974 42 None None None 159040337 Common - Protein-N(pi)-phosphohistidine--sugar phosphotransferase Sare_4849 41 COG2213 MtlA, Phosphotransferase system, mannitol-specific IIBC component Carbohydrate transport and metabolism 159036849 Common - peptidase M23B Sare_1203 16 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 159039158 Common - acyl carrier protein Sare_3622 205 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159038599 Nonpathogen - hypothetical protein Sare_3040 10 None None None 159038913 Common - ABC transporter related Sare_3373 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 159039182 Common - polymorphic outer membrane protein Sare_3646 12 None None None 159037716 Common - major facilitator superfamily MFS_1 Sare_2113 189 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159037126 Nonpathogen - hypothetical protein Sare_1490 1 None None None 159038959 Nonpathogen - hypothetical protein Sare_3419 1 None None None 159037222 Common - Integrase catalytic region Sare_1591 75 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 159037805 Common - transcriptional regulator, AraC family Sare_2206 118 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 159036810 Common - transcriptional regulator, AsnC family Sare_1164 32 COG1522 Lrp, Transcriptional regulators Transcription 159037215 Nonpathogen - hypothetical protein Sare_1582 1 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 159037127 Common - GCN5-related N-acetyltransferase Sare_1491 13 COG0456 RimI, Acetyltransferases General function prediction only 159040434 Common - Methyltransferase type 11 Sare_4950 104 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159035892 Common - two component transcriptional regulator, winged helix family Sare_0219 211 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159038823 Common - thioester reductase domain Sare_3282 237 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159037835 Common - transcriptional regulator, AsnC family Sare_2237 146 COG1522 Lrp, Transcriptional regulators Transcription 159037334 Common - ATP-dependent helicase HrpA Sare_1709 131 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 159038924 Common - Palmitoyl-CoA hydrolase Sare_3384 77 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 159038074 Common - hypothetical protein Sare_2493 9 None None None 159040536 Common - hypothetical protein Sare_5055 17 None None None 159036947 Common - 4-oxalocrotonate tautomerase Sare_1308 13 COG1942 COG1942, Uncharacterized protein, 4-oxalocrotonate tautomerase homolog General function prediction only 159037481 Common - hypothetical protein Sare_1858 193 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 159037273 Common - adenylate/guanylate cyclase Sare_1643 93 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 159038066 Common - hypothetical protein Sare_2485 65 COG2270 COG2270, Permeases of the major facilitator superfamily General function prediction only 159039294 Nonpathogen - hypothetical protein Sare_3763 1 None None None 159036817 Common - putative methyltransferase Sare_1171 211 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 159037692 Common - Acyl-CoA dehydrogenase type 2 domain Sare_2089 59 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159035928 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Sare_0258 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 159038747 Common - amidohydrolase 2 Sare_3202 14 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 159040310 Common - alpha/beta hydrolase fold Sare_4822 154 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159037112 Common - Chlorite dismutase Sare_1476 35 COG3253 COG3253, Uncharacterized conserved protein Function unknown 159040251 Common - hypothetical protein Sare_4760 52 COG2843 PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) Cell envelope biogenesis, outer membrane 159037738 Common - monooxygenase FAD-binding Sare_2135 110 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 159038399 Common - fumarate reductase/succinate dehydrogenase flavoprotein domain protein Sare_2826 59 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 159038384 Common - cytochrome P450 Sare_2811 69 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159038776 Common - transcriptional regulator, PucR family Sare_3231 16 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 159038241 Common - major facilitator superfamily MFS_1 Sare_2666 24 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159040056 Common - daunorubicin resistance ABC transporter ATPase subunit Sare_4550 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159037067 Common - binding-protein-dependent transport systems inner membrane component Sare_1430 96 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 159039222 Nonpathogen - hypothetical protein Sare_3691 1 None None None 159036121 Common - UBA/THIF-type NAD/FAD binding protein Sare_0454 225 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 159036306 Common - pyruvate flavodoxin/ferredoxin oxidoreductase domain protein Sare_0646 106 COG0674 PorA, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit Energy production and conversion 159040281 Common - hypothetical protein Sare_4790 16 None None None 159036117 Common - DEAD/DEAH box helicase domain protein Sare_0450 235 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 159036559 Common - two component transcriptional regulator, winged helix family Sare_0904 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159037366 Common - hypothetical protein Sare_1741 4 None None None 159040319 Nonpathogen - hypothetical protein Sare_4831 1 None None None 159036037 Nonpathogen - hypothetical protein Sare_0370 1 None None None 159038293 Common - hypothetical protein Sare_2718 9 COG3559 TnrB3, Putative exporter of polyketide antibiotics Cell envelope biogenesis, outer membrane 159037846 Common - hypothetical protein Sare_2248 17 None None None 159039403 Nonpathogen - hypothetical protein Sare_3873 1 None None None 159040300 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Sare_4812 46 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 159039548 Nonpathogen - hypothetical protein Sare_4020 2 COG3158 Kup, K+ transporter Inorganic ion transport and metabolism 159036513 Common - Ribonuclease Z Sare_0857 118 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 159040473 Common - acetyl-CoA acetyltransferase Sare_4992 175 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 159037728 Common - Hemerythrin HHE cation binding domain protein Sare_2125 8 None None None 159038839 Common - ABC transporter related Sare_3298 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 159040120 Common - transcriptional regulator, ArsR family Sare_4624 35 COG0640 ArsR, Predicted transcriptional regulators Transcription 159036671 Common - ErfK/YbiS/YcfS/YnhG family protein Sare_1022 32 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 159039468 Nonpathogen - hypothetical protein Sare_3940 1 None None None 159036618 Common - major facilitator superfamily MFS_1 Sare_0968 59 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159037729 Nonpathogen - hypothetical protein Sare_2126 1 None None None 159038738 Common - short-chain dehydrogenase/reductase SDR Sare_3193 217 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 159040012 Common - peptidase M14 carboxypeptidase A Sare_4502 24 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 159038254 Nonpathogen - hypothetical protein Sare_2679 1 None None None 159036889 Common - AMP-dependent synthetase and ligase Sare_1246 237 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159038356 Nonpathogen - hypothetical protein Sare_2783 1 None None None 159036098 Common - GCN5-related N-acetyltransferase Sare_0431 6 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 159039898 Nonpathogen - hypothetical protein Sare_4379 1 None None None 159037840 Common - ErfK/YbiS/YcfS/YnhG family protein Sare_2242 22 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 159038425 Common - N-6 DNA methylase Sare_2853 159 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 159037899 Nonpathogen - hypothetical protein Sare_2303 1 None None None 159037021 Common - histidine kinase Sare_1383 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159039807 Common - ribosomal protein S11 Sare_4288 247 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 159039507 Common - Roadblock/LC7 family protein Sare_3979 9 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 159037508 Common - ornithine carbamoyltransferase Sare_1885 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 159038592 Nonpathogen - hypothetical protein Sare_3032 3 None None None 159038309 Common - GCN5-related N-acetyltransferase Sare_2736 40 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 159036274 Nonpathogen - hypothetical protein Sare_0608 1 None None None 159038110 Nonpathogen - hypothetical protein Sare_2529 1 None None None 159036137 Nonpathogen - NADH-ubiquinone oxidoreductase chain 4L Sare_0470 1 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 159039800 Common - aldo/keto reductase Sare_4281 195 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 159038438 Common - hypothetical protein Sare_2873 10 COG3541 COG3541, Predicted nucleotidyltransferase General function prediction only 159039194 Nonpathogen - hypothetical protein Sare_3659 1 None None None 159035758 Common - protein serine/threonine phosphatase Sare_0085 42 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 159036599 Common - cell divisionFtsK/SpoIIIE Sare_0946 63 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 159039425 Common - amidohydrolase 2 Sare_3896 45 COG2159 COG2159, Predicted metal-dependent hydrolase of the TIM-barrel fold General function prediction only 159038621 Common - protein of unknown function DUF201 Sare_3064 53 COG0439 AccC, Biotin carboxylase Lipid metabolism 159037518 Common - thioesterase superfamily protein Sare_1895 86 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 159036079 Common - protein of unknown function DUF214 Sare_0412 164 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 159037771 Common - O-methyltransferase family 2 Sare_2170 28 COG4742 COG4742, Predicted transcriptional regulator Transcription 159037156 Common - methyltransferase small Sare_1522 26 COG3897 COG3897, Predicted methyltransferase General function prediction only 159039121 Nonpathogen - hypothetical protein Sare_3583 2 None None None 159040111 Common - DsrC family protein Sare_4615 59 COG2920 DsrC, Dissimilatory sulfite reductase (desulfoviridin), gamma subunit Inorganic ion transport and metabolism 159040295 Common - hypothetical protein Sare_4805 6 None None None 159040396 Nonpathogen - hypothetical protein Sare_4909 1 None None None 159037676 Common - Beta-ketoacyl synthase Sare_2072 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159039824 Common - ribosomal protein L14 Sare_4305 247 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 159037403 Common - SNO glutamine amidotransferase Sare_1778 86 COG0311 PDX2, Predicted glutamine amidotransferase involved in pyridoxine biosynthesis Coenzyme metabolism 159039717 Common - phosphoribosylglycinamide formyltransferase Sare_4198 218 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 159037394 Nonpathogen - ADP-ribosylation/Crystallin J1 Sare_1769 6 COG1397 DraG, ADP-ribosylglycohydrolase Posttranslational modification, protein turnover, chaperones 159040522 Nonpathogen - hypothetical protein Sare_5041 22 COG4880 COG4880, Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats General function prediction only 159036768 Common - diguanylate cyclase/phosphodiesterase Sare_1122 176 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 159040128 Common - transcriptional regulator, AraC family Sare_4632 3 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 159039016 Nonpathogen - CDP-alcohol phosphatidyltransferase Sare_3476 2 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 159039611 Common - phosphoadenosine phosphosulfate reductase Sare_4083 165 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 159036552 Common - aldehyde dehydrogenase Sare_0897 217 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 159038999 Common - protein of unknown function DUF58 Sare_3459 52 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 159040136 Common - ADP-ribosylation/Crystallin J1 Sare_4641 59 COG1397 DraG, ADP-ribosylglycohydrolase Posttranslational modification, protein turnover, chaperones 159038081 Common - peptidase M23B Sare_2500 185 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 159038178 Nonpathogen - prevent-host-death family protein Sare_2599 1 COG4118 Phd, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 159037318 Common - two component transcriptional regulator, winged helix family Sare_1693 207 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159039478 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Sare_3950 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 159037398 Common - CDP-alcohol phosphatidyltransferase Sare_1773 46 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 159040544 Common - hypothetical protein Sare_5063 27 COG3809 COG3809, Uncharacterized protein conserved in bacteria Function unknown 159037473 Common - Dihydroorotate oxidase Sare_1850 199 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 159036280 Nonpathogen - hypothetical protein Sare_0615 1 None None None 159039231 Nonpathogen - hypothetical protein Sare_3700 1 None None None 159037343 Nonpathogen - hypothetical protein Sare_1718 1 None None None 159037962 Common - hypothetical protein Sare_2366 12 None None None 159035967 Nonpathogen - hypothetical protein Sare_0299 1 None None None 159040501 Common - cell envelope-related transcriptional attenuator Sare_5020 61 COG1316 LytR, Transcriptional regulator Transcription 159039571 Common - Erythromycin esterase Sare_4043 32 COG2312 COG2312, Erythromycin esterase homolog General function prediction only 159036541 Common - F420-dependent oxidoreductase, putative Sare_0885 44 COG1478 COG1478, Uncharacterized conserved protein Function unknown 159040029 Common - Phosphoglycerate mutase Sare_4519 37 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 159040156 Nonpathogen - putative transmembrane anti-sigma factor Sare_4665 1 COG5662 COG5662, Predicted transmembrane transcriptional regulator (anti-sigma factor) Transcription 159037113 Common - hypothetical protein Sare_1477 10 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 159039019 Common - hypothetical protein Sare_3479 15 None None None 159039390 Common - ribosomal protein L21 Sare_3860 199 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 159040190 Common - DNA repair protein RadA Sare_4699 201 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 159038629 Common - polymorphic outer membrane protein Sare_3075 11 None None None 159036233 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Sare_0567 230 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 159036349 Common - diguanylate cyclase with GAF sensor Sare_0691 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 159036804 Common - Cys/Met metabolism pyridoxal-phosphate-dependent protein Sare_1158 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 159038164 Common - ABC transporter related Sare_2585 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159038033 Common - FAD linked oxidase domain protein Sare_2448 40 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 159038468 Common - ribosomal protein L33 Sare_2904 129 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 159038893 Common - cold-shock DNA-binding domain protein Sare_3353 182 COG1278 CspC, Cold shock proteins Transcription 159038722 Common - peptidase alpha-lytic pro domain Sare_3177 8 None None None 159036204 Nonpathogen - hypothetical protein Sare_0537 1 None None None 159039184 Common - peptidase M50 Sare_3648 74 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 159039096 Common - hypothetical protein Sare_3556 81 COG2843 PgsA, Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) Cell envelope biogenesis, outer membrane 159036577 Common - methylthioadenosine phosphorylase Sare_0922 122 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 159039886 Common - OsmC family protein Sare_4367 38 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 159040118 Common - oxidoreductase FAD/NAD(P)-binding domain protein Sare_4622 138 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 159035842 Common - hypothetical protein Sare_0169 7 None None None 159040024 Common - UbiD family decarboxylase Sare_4514 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 159038574 Nonpathogen - hypothetical protein Sare_3012 1 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159039559 Common - acriflavin resistance protein Sare_4031 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 159038796 Common - ATPase associated with various cellular activities AAA_3 Sare_3254 172 COG0714 COG0714, MoxR-like ATPases General function prediction only 159038335 Common - FAD-binding 9 siderophore-interacting domain protein Sare_2762 63 COG2375 ViuB, Siderophore-interacting protein Inorganic ion transport and metabolism 159039310 Nonpathogen - hypothetical protein Sare_3779 1 None None None 159038236 Common - FMN-dependent alpha-hydroxy acid dehydrogenase Sare_2661 108 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 159039161 Nonpathogen - hypothetical protein Sare_3625 1 None None None 159036386 Nonpathogen - hypothetical protein Sare_0729 1 None None None 159036241 Common - fumarate reductase/succinate dehydrogenase flavoprotein domain protein Sare_0575 57 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 159036928 Nonpathogen - Terpene synthase metal-binding domain protein Sare_1287 2 None None None 159039659 Common - UvrD/REP helicase Sare_4131 106 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 159035885 Common - acyltransferase 3 Sare_0212 80 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 159039236 Nonpathogen - hypothetical protein Sare_3705 1 None None None 159038646 Nonpathogen - hypothetical protein Sare_3095 1 None None None 159036726 Common - extracellular solute-binding protein family 1 Sare_1080 68 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 159039412 Common - Alcohol dehydrogenase zinc-binding domain protein Sare_3883 192 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 159039241 Nonpathogen - hypothetical protein Sare_3710 1 None None None 159039890 Nonpathogen - hypothetical protein Sare_4371 1 None None None 159039901 Common - regulator of chromosome condensation, RCC1 Sare_4382 28 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 159037812 Common - cold-shock DNA-binding domain protein Sare_2213 63 COG1278 CspC, Cold shock proteins Transcription 159037878 Nonpathogen - hypothetical protein Sare_2282 7 COG2263 COG2263, Predicted RNA methylase Translation, ribosomal structure and biogenesis 159037986 Nonpathogen - FxsA cytoplasmic membrane protein Sare_2390 1 COG3030 FxsA, Protein affecting phage T7 exclusion by the F plasmid General function prediction only 159039323 Nonpathogen - hypothetical protein Sare_3792 2 None None None 159039733 Common - two component transcriptional regulator, LuxR family Sare_4214 203 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159039854 Common - diguanylate cyclase/phosphodiesterase with GAF sensor Sare_4335 176 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 159035697 Nonpathogen - hypothetical protein Sare_0023 1 None None None 159039068 Common - hypothetical protein Sare_3528 31 COG3336 COG3336, Predicted membrane protein Function unknown 159037414 Common - hypothetical protein Sare_1790 6 None None None 159037795 Nonpathogen - hypothetical protein Sare_2196 6 COG4076 COG4076, Predicted RNA methylase General function prediction only 159037832 Common - Glycine hydroxymethyltransferase Sare_2234 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 159038992 Nonpathogen - monovalent cation/proton antiporter, MnhG/PhaG subunit Sare_3452 1 COG1320 MnhG, Multisubunit Na+/H+ antiporter, MnhG subunit Inorganic ion transport and metabolism 159036018 Common - transcriptional regulator, LuxR family Sare_0350 61 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159036389 Common - UDP-N-acetylglucosamine pyrophosphorylase Sare_0732 230 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 159036390 Common - ribose-phosphate pyrophosphokinase Sare_0733 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 159038048 Common - Radical SAM domain protein Sare_2465 68 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 159037485 Common - methionyl-tRNA formyltransferase Sare_1862 216 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 159037345 Common - sulfotransferase Sare_1720 5 None None None 159036641 Common - beta-lactamase domain protein Sare_0992 62 COG1234 ElaC, Metal-dependent hydrolases of the beta-lactamase superfamily III General function prediction only 159039370 Common - Enoyl-CoA hydratase/isomerase Sare_3839 151 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 159040268 Common - ROK family protein Sare_4777 170 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 159036425 Common - peptidase M48 Ste24p Sare_0768 11 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 159039625 Common - transcription factor WhiB Sare_4097 19 None None None 159040220 Common - hypothetical protein Sare_4729 5 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 159039313 Nonpathogen - hypothetical protein Sare_3782 1 None None None 159038297 Nonpathogen - hypothetical protein Sare_2722 7 None None None 159038806 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sare_3265 8 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159039168 Common - hypothetical protein Sare_3632 5 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 159036094 Common - porphobilinogen deaminase Sare_0427 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 159037672 Common - hypothetical protein Sare_2068 7 None None None 159036263 Nonpathogen - hypothetical protein Sare_0597 3 None None None 159039267 Nonpathogen - hypothetical protein Sare_3736 1 None None None 159037013 Nonpathogen - hypothetical protein Sare_1375 1 None None None 159037936 Common - NDP-hexose 23-dehydratase Sare_2340 9 None None None 159038189 Common - gamma-glutamyltransferase Sare_2611 147 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 159038104 Common - protein of unknown function DUF1290 Sare_2523 25 COG3856 Sbp, Uncharacterized conserved protein (small basic protein) Function unknown 159036940 Nonpathogen - protein of unknown function DUF397 Sare_1301 2 None None None 159039032 Common - binding-protein-dependent transport systems inner membrane component Sare_3492 170 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 159035809 Common - hypothetical protein Sare_0136 14 None None None 159037209 Common - transcriptional regulator, GntR family Sare_1575 78 COG2188 PhnF, Transcriptional regulators Transcription 159037937 Common - glutamate decarboxylase Sare_2341 64 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 159037202 Common - cell division FtsK/SpoIIIE Sare_1568 14 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 159037551 Nonpathogen - hypothetical protein Sare_1928 1 None None None 159037852 Common - serine/threonine protein kinase Sare_2255 158 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 159035905 Common - O-methyltransferase family 2 Sare_0232 65 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 159036600 Common - cold-shock DNA-binding domain protein Sare_0948 181 COG1278 CspC, Cold shock proteins Transcription 159036004 Common - polysaccharide deacetylase Sare_0336 101 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 159038063 Common - cytochrome bd ubiquinol oxidase subunit I Sare_2482 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 159037825 Nonpathogen - hypothetical protein Sare_2227 3 None None None 159039269 Nonpathogen - hypothetical protein Sare_3738 1 None None None 159037046 Nonpathogen - hypothetical protein Sare_1408 7 COG3846 TrbL, Type IV secretory pathway, TrbL components Intracellular trafficking and secretion 159038743 Nonpathogen - hypothetical protein Sare_3198 1 None None None 159036344 Nonpathogen - hypothetical protein Sare_0685 1 None None None 159038201 Common - hypothetical protein Sare_2623 8 None None None 159036435 Common - putative lipoprotein Sare_0778 36 None None None 159037115 Common - GCN5-related N-acetyltransferase Sare_1479 80 COG2153 ElaA, Predicted acyltransferase General function prediction only 159038347 Common - Alkylglycerone-phosphate synthase Sare_2774 177 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 159038142 Nonpathogen - hypothetical protein Sare_2562 1 COG4828 COG4828, Predicted membrane protein Function unknown 159036983 Common - protein of unknown function DUF1006 Sare_1344 61 COG3214 COG3214, Uncharacterized protein conserved in bacteria Function unknown 159037255 Common - aldehyde dehydrogenase Sare_1625 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 159038358 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sare_2785 151 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159036014 Common - transposase Tn3 family protein Sare_0346 54 COG4644 COG4644, Transposase and inactivated derivatives, TnpA family DNA replication, recombination, and repair 159038971 Nonpathogen - hypothetical protein Sare_3431 2 None None None 159040436 Common - hypothetical protein Sare_4952 9 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 159038798 Common - membrane-flanked domain Sare_3257 23 COG3428 COG3428, Predicted membrane protein Function unknown 159039951 Common - hypothetical protein Sare_4439 3 None None None 159038464 Common - protein of unknown function DUF985 Sare_2900 57 COG3542 COG3542, Uncharacterized conserved protein Function unknown 159040243 Common - protein of unknown function DUF571 Sare_4752 7 None None None 159038017 Common - hypothetical protein Sare_2424 2 None None None 159038694 Common - thioester reductase domain Sare_3148 187 COG3320 COG3320, Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 159040257 Common - acyl-CoA dehydrogenase domain protein Sare_4766 156 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159038471 Common - Radical SAM domain protein Sare_2907 109 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 159038354 Common - hypothetical protein Sare_2781 18 COG3559 TnrB3, Putative exporter of polyketide antibiotics Cell envelope biogenesis, outer membrane 159039917 Nonpathogen - hypothetical protein Sare_4402 1 None None None 159036570 Common - delta-1-pyrroline-5-carboxylate dehydrogenase Sare_0915 218 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 159039407 Common - Endopeptidase Clp Sare_3877 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 159036125 Common - Methylated-DNA-(protein)-cysteine S-methyltransferase DNA binding Sare_0458 21 COG3695 COG3695, Predicted methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 159038619 Nonpathogen - hypothetical protein Sare_3062 1 None None None 159040413 Common - isopentenyl-diphosphate delta-isomerase, type 1 Sare_4928 41 COG1443 Idi, Isopentenyldiphosphate isomerase Lipid metabolism 159038855 Common - hypothetical protein Sare_3314 4 None None None 159040173 Common - histidinol-phosphate aminotransferase Sare_4682 233 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 159036458 Nonpathogen - hypothetical protein Sare_0801 1 None None None 159036521 Common - threonine dehydratase Sare_0865 195 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 159035743 Nonpathogen - hypothetical protein Sare_0069 1 None None None 159037981 Common - cobalamin B12-binding domain protein Sare_2385 17 COG2185 Sbm, Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) Lipid metabolism 159036361 Common - inner-membrane translocator Sare_0704 11 COG4177 LivM, ABC-type branched-chain amino acid transport system, permease component Amino acid transport and metabolism 159040540 Common - molybdenum cofactor biosynthesis protein C Sare_5059 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 159037031 Common - polar amino acid ABC transporter, inner membrane subunit Sare_1393 174 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 159037107 Common - peptidase S1 and S6 chymotrypsin/Hap Sare_1471 161 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 159036528 Common - phosphoribosylaminoimidazole carboxylase, ATPase subunit Sare_0872 191 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 159038784 Common - putative ferredoxin Sare_3242 19 COG1141 Fer, Ferredoxin Energy production and conversion 159039878 Common - NUDIX hydrolase Sare_4359 85 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 159035738 Nonpathogen - hypothetical protein Sare_0064 1 None None None 159036397 Common - CBS domain containing protein Sare_0740 217 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 159039214 Nonpathogen - hypothetical protein Sare_3683 1 None None None 159038729 Common - 8-amino-7-oxononanoate synthase Sare_3184 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 159037477 Common - guanylate kinase/L-type calcium channel region Sare_1854 23 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 159037932 Common - dTDP-glucose 4,6-dehydratase Sare_2336 231 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 159038526 Common - amino acid adenylation domain Sare_2962 192 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159036669 Common - hypothetical protein Sare_1020 7 None None None 159039394 Nonpathogen - hypothetical protein Sare_3864 1 COG3115 ZipA, Cell division protein Cell division and chromosome partitioning 159039710 Common - ABC transporter related Sare_4186 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 159040445 Common - Enoyl-CoA hydratase/isomerase Sare_4961 180 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 159037857 Common - protein of unknown function UPF0016 Sare_2260 72 COG2119 COG2119, Predicted membrane protein Function unknown 159039680 Common - NUDIX hydrolase Sare_4152 94 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 159036056 Common - transcriptional regulator, LacI family Sare_0389 127 COG1609 PurR, Transcriptional regulators Transcription 159036319 Common - peptidase S1 and S6 chymotrypsin/Hap Sare_0659 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 159036638 Common - Mov34/MPN/PAD-1 family protein Sare_0989 27 COG1310 COG1310, Predicted metal-dependent protease of the PAD1/JAB1 superfamily General function prediction only 159037434 Nonpathogen - hypothetical protein Sare_1810 1 None None None 159040471 Common - two component transcriptional regulator, winged helix family Sare_4990 213 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159037197 Common - replication initiation protein Sare_1563 5 None None None 159038286 Common - hypothetical protein Sare_2711 9 None None None 159037785 Common - Methyltransferase type 11 Sare_2185 125 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159038536 Nonpathogen - hypothetical protein Sare_2973 1 None None None 159035821 Common - acetyl-CoA acetyltransferase Sare_0148 168 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 159039045 Common - Endonuclease/exonuclease/phosphatase Sare_3505 8 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 159037955 Common - protein of unknown function DUF245 domain protein Sare_2359 16 None None None 159039699 Common - adenylylsulfate kinase Sare_4172 150 COG0529 CysC, Adenylylsulfate kinase and related kinases Inorganic ion transport and metabolism 159038180 Common - protein of unknown function DUF397 Sare_2601 6 None None None 159036772 Common - D-3-phosphoglycerate dehydrogenase Sare_1126 230 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 159037469 Common - aspartate carbamoyltransferase Sare_1846 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 159038053 Nonpathogen - hypothetical protein Sare_2471 1 COG2020 STE14, Putative protein-S-isoprenylcysteine methyltransferase Posttranslational modification, protein turnover, chaperones 159039078 Common - quinolinate synthetase complex, A subunit Sare_3538 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 159039742 Common - GMP synthase, large subunit Sare_4223 239 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 159038663 Common - protein of unknown function DUF1028 Sare_3117 20 COG3342 COG3342, Uncharacterized conserved protein Function unknown 159036088 Common - glutaredoxin 2 Sare_0421 24 None None None 159040589 Common - protein of unknown function DUF37 Sare_5109 165 COG0759 COG0759, Uncharacterized conserved protein Function unknown 159039034 Common - extracellular solute-binding protein family 1 Sare_3494 72 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 159040488 Common - signal transduction histidine kinase, LytS Sare_5007 105 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 159037305 Common - 4-diphosphocytidyl-2C-methyl-D-erythritol synthase Sare_1679 231 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 159036984 Common - hypothetical protein Sare_1345 13 None None None 159039454 Nonpathogen - hypothetical protein Sare_3925 1 None None None 159037704 Common - Alcohol dehydrogenase GroES domain protein Sare_2101 203 COG1064 AdhP, Zn-dependent alcohol dehydrogenases General function prediction only 159039043 Nonpathogen - hypothetical protein Sare_3503 1 None None None 159038117 Common - protein of unknown function DUF1271 Sare_2537 7 COG1141 Fer, Ferredoxin Energy production and conversion 159036358 Common - extracellular ligand-binding receptor Sare_0701 90 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 159036764 Common - hypothetical protein Sare_1118 3 None None None 159036327 Common - protein of unknown function DUF6 transmembrane Sare_0667 22 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 159039836 Common - translation elongation factor Tu Sare_4317 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 159038209 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Sare_2632 52 COG0546 Gph, Predicted phosphatases General function prediction only 159038637 Common - Helicase superfamily 1 and 2 ATP-binding Sare_3086 100 COG1205 COG1205, Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster General function prediction only 159036800 Nonpathogen - hypothetical protein Sare_1154 2 None None None 159037650 Common - hypothetical protein Sare_2045 7 COG3832 COG3832, Uncharacterized conserved protein Function unknown 159037915 Common - Phosphoglycerate mutase Sare_2319 98 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 159038012 Nonpathogen - hypothetical protein Sare_2418 3 None None None 159039753 Common - ybaK/ebsC protein Sare_4234 123 COG2606 EbsC, Uncharacterized conserved protein Function unknown 159040213 Nonpathogen - hypothetical protein Sare_4722 1 None None None 159036502 Common - protein of unknown function DUF58 Sare_0846 31 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 159036062 Common - UDP-N-acetylenolpyruvoylglucosamine reductase Sare_0395 193 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 159039400 Nonpathogen - hypothetical protein Sare_3870 1 None None None 159035756 Common - phosphoribosyltransferase Sare_0083 81 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 159036441 Common - threonyl-tRNA synthetase Sare_0784 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159036509 Common - lipolytic protein G-D-S-L family Sare_0853 15 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 159038307 Common - ABC transporter related Sare_2734 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 159038212 Common - metal dependent phosphohydrolase Sare_2635 18 COG4341 COG4341, Predicted HD phosphohydrolase General function prediction only 159039381 Common - hypothetical protein Sare_3850 14 None None None 159040508 Common - Arginine deiminase Sare_5027 51 COG2235 ArcA, Arginine deiminase Amino acid transport and metabolism 159036193 Nonpathogen - hypothetical protein Sare_0526 1 None None None 159038659 Common - protein of unknown function DUF58 Sare_3113 22 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 159037745 Common - hypothetical protein Sare_2142 26 COG3467 COG3467, Predicted flavin-nucleotide-binding protein General function prediction only 159039220 Nonpathogen - hypothetical protein Sare_3689 1 None None None 159038993 Nonpathogen - multiple resistance and pH regulation protein F Sare_3453 1 COG2212 MnhF, Multisubunit Na+/H+ antiporter, MnhF subunit Inorganic ion transport and metabolism 159040194 Common - hypothetical protein Sare_4703 7 None None None 159039774 Common - nitrite transporter Sare_4255 84 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 159037059 Common - Rhodanese domain protein Sare_1421 143 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 159038605 Nonpathogen - hypothetical protein Sare_3048 1 None None None 159039039 Common - transcriptional regulator, Crp/Fnr family Sare_3499 163 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 159040323 Common - hypothetical protein Sare_4835 7 None None None 159036235 Common - aminotransferase class-III Sare_0569 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 159038375 Common - aldehyde dehydrogenase Sare_2802 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 159037663 Common - hypothetical protein Sare_2058 3 None None None 159036972 Nonpathogen - hypothetical protein Sare_1333 1 None None None 159038683 Common - protein of unknown function DUF323 Sare_3137 105 COG1262 COG1262, Uncharacterized conserved protein Function unknown 159039727 Common - chorismate mutase Sare_4208 3 COG1605 PheA, Chorismate mutase Amino acid transport and metabolism 159038555 Nonpathogen - hypothetical protein Sare_2993 1 None None None 159037862 Common - hypothetical protein Sare_2265 13 COG5502 COG5502, Uncharacterized conserved protein Function unknown 159038008 Common - transcriptional regulator, TetR family Sare_2413 17 COG1309 AcrR, Transcriptional regulator Transcription 159040109 Common - transcriptional regulator, ArsR family Sare_4613 163 COG0640 ArsR, Predicted transcriptional regulators Transcription 159040073 Common - pyruvate carboxyltransferase Sare_4567 207 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 159040518 Common - hypothetical protein Sare_5037 23 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 159039026 Common - glycine betaine/L-proline ABC transporter, ATPase subunit Sare_3486 249 COG4175 ProV, ABC-type proline/glycine betaine transport system, ATPase component Amino acid transport and metabolism 159040002 Nonpathogen - hypothetical protein Sare_4492 1 None None None 159037668 Common - peptidase S45 penicillin amidase Sare_2063 58 COG2366 COG2366, Protein related to penicillin acylase General function prediction only 159040048 Nonpathogen - hypothetical protein Sare_4538 1 None None None 159038714 Common - ABC transporter related Sare_3169 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 159038885 Common - hypothetical protein Sare_3344 5 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 159039415 Nonpathogen - hypothetical protein Sare_3886 1 None None None 159039605 Nonpathogen - Superoxide dismutase Sare_4077 13 None None None 159035854 Nonpathogen - hypothetical protein Sare_0181 1 None None None 159038332 Common - NAD-dependent epimerase/dehydratase Sare_2759 211 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 159039921 Common - transcriptional regulator, TetR family Sare_4406 54 COG1309 AcrR, Transcriptional regulator Transcription 159040038 Common - major facilitator superfamily MFS_1 Sare_4528 61 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 159036168 Common - major facilitator superfamily MFS_1 Sare_0501 11 None None None 159039143 Common - protein of unknown function DUF1211 Sare_3607 12 COG3548 COG3548, Predicted integral membrane protein Function unknown 159036657 Common - cobalt ABC transporter, inner membrane subunit CbiQ Sare_1008 44 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 159038827 Common - hypothetical protein Sare_3286 7 COG3170 FimV, Tfp pilus assembly protein FimV Cell motility and secretion / Intracellular trafficking and secretion 159040185 Common - 3-Oxoacyl-(acyl-carrier-protein (ACP)) synthase III domain protein Sare_4694 38 COG3424 BcsA, Predicted naringenin-chalcone synthase Secondary metabolites biosynthesis, transport, and catabolism 159036554 Common - protein of unknown function DUF343 Sare_0899 29 COG2835 COG2835, Uncharacterized conserved protein Function unknown 159039867 Common - transcriptional regulator, TetR family Sare_4348 59 COG1309 AcrR, Transcriptional regulator Transcription 159036998 Nonpathogen - hypothetical protein Sare_1359 1 None None None 159038080 Common - transcriptional regulator, TetR family Sare_2499 7 COG1309 AcrR, Transcriptional regulator Transcription 159039282 Nonpathogen - hypothetical protein Sare_3751 1 None None None 159038673 Nonpathogen - GCN5-related N-acetyltransferase Sare_3127 2 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 159035783 Nonpathogen - hypothetical protein Sare_0110 1 None None None 159038025 Nonpathogen - hypothetical protein Sare_2438 1 None None None 159040166 Common - hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit Sare_4675 146 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 159035997 Common - phosphate uptake regulator, PhoU Sare_0329 190 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 159038441 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_2877 26 None None None 159036530 Nonpathogen - hypothetical protein Sare_0874 2 None None None 159036371 Common - proton-translocating NADH-quinone oxidoreductase, chain M Sare_0714 210 COG1008 NuoM, NADH:ubiquinone oxidoreductase subunit 4 (chain M) Energy production and conversion 159037464 Common - 3-dehydroquinate dehydratase, type II Sare_1841 169 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 159036236 Common - Methionine--tRNA ligase Sare_0570 203 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159037837 Common - Transketolase central region Sare_2239 178 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 159040459 Nonpathogen - peptidase A24A prepilin type IV Sare_4975 1 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 159039872 Common - Ku family containing protein Sare_4353 63 COG1273 COG1273, Uncharacterized conserved protein Function unknown 159037624 Nonpathogen - hypothetical protein Sare_2010 1 None None None 159039336 Common - putative deoxyguanosinetriphosphate triphosphohydrolase Sare_3805 161 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 159039769 Common - glucosamine--fructose-6-phosphate aminotransferase, isomerizing Sare_4250 237 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 159036154 Common - phosphopantetheine-binding Sare_0487 12 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159037165 Common - heavy metal translocating P-type ATPase Sare_1531 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 159036745 Common - Enoyl-CoA hydratase/isomerase Sare_1099 187 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 159037106 Common - 3'-5' exonuclease Sare_1470 111 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 159039139 Common - Non-specific serine/threonine protein kinase Sare_3603 128 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 159039883 Common - hypothetical protein Sare_4364 17 COG4244 COG4244, Predicted membrane protein Function unknown 159035801 Nonpathogen - hypothetical protein Sare_0128 1 None None None 159037348 Common - hypothetical protein Sare_1723 24 COG3224 COG3224, Uncharacterized protein conserved in bacteria Function unknown 159040372 Common - ABC transporter related Sare_4885 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 159037442 Nonpathogen - hypothetical protein Sare_1818 3 None None None 159039655 Common - peptidase M16 domain protein Sare_4127 140 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 159037699 Common - glucose-1-phosphate thymidyltransferase Sare_2096 235 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 159039585 Common - CutA1 divalent ion tolerance protein Sare_4057 63 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 159040465 Common - transcriptional regulator, MerR family Sare_4984 120 COG0789 SoxR, Predicted transcriptional regulators Transcription 159036734 Nonpathogen - hypothetical protein Sare_1088 1 None None None 159035728 Common - glutamine amidotransferase of anthranilate synthase Sare_0054 232 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 159036899 Common - oxidoreductase domain protein Sare_1256 122 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 159040460 Common - NUDIX hydrolase Sare_4976 43 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 159035965 Common - ABC transporter related Sare_0296 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159039532 Common - ABC transporter related Sare_4004 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159040367 Common - inositol monophosphatase Sare_4879 114 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 159038316 Common - transport system permease protein Sare_2743 177 COG4779 FepG, ABC-type enterobactin transport system, permease component Inorganic ion transport and metabolism 159037568 Nonpathogen - DNA-binding protein Sare_1945 4 COG1661 COG1661, Predicted DNA-binding protein with PD1-like DNA-binding motif General function prediction only 159038433 Common - transcriptional regulator, LysR family Sare_2867 155 COG0583 LysR, Transcriptional regulator Transcription 159035804 Common - transcriptional regulator, ArsR family Sare_0131 175 COG0640 ArsR, Predicted transcriptional regulators Transcription 159039475 Common - peptidase M16 domain protein Sare_3947 106 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 159036660 Common - DoxX family protein Sare_1011 8 COG2259 COG2259, Predicted membrane protein Function unknown 159040009 Common - ABC transporter related Sare_4499 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 159036907 Common - DegT/DnrJ/EryC1/StrS aminotransferase Sare_1264 190 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 159038498 Nonpathogen - hypothetical protein Sare_2934 1 None None None 159036072 Common - hypothetical protein Sare_0405 9 None None None 159038155 Common - CRISPR-associated protein, Cse4 family Sare_2575 42 None None None 159039497 Common - binding-protein-dependent transport systems inner membrane component Sare_3969 153 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 159040549 Common - ribosomal protein S6 Sare_5068 202 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 159038848 Common - FeS assembly ATPase SufC Sare_3307 249 COG0396 SufC, ABC-type transport system involved in Fe-S cluster assembly, ATPase component Posttranslational modification, protein turnover, chaperones 159039841 Nonpathogen - hypothetical protein Sare_4322 1 None None None 159037144 Common - transcriptional regulator, LacI family Sare_1510 129 COG1609 PurR, Transcriptional regulators Transcription 159039373 Common - hypothetical protein Sare_3842 9 None None None 159040531 Nonpathogen - hypothetical protein Sare_5050 1 None None None 159039663 Common - hypothetical protein Sare_4135 35 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 159037527 Common - DNA repair protein RecN Sare_1904 197 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 159038691 Common - transcriptional regulator, TrmB Sare_3145 13 COG2345 COG2345, Predicted transcriptional regulator Transcription 159039296 Common - phage-related major capsid protein Sare_3765 4 None None None 159040293 Nonpathogen - hypothetical protein Sare_4803 1 None None None 159038820 Common - amidohydrolase Sare_3279 154 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 159036877 Common - ribosome recycling factor Sare_1233 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 159039900 Common - extracellular solute-binding protein family 5 Sare_4381 200 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 159037573 Nonpathogen - hypothetical protein Sare_1950 1 None None None 159037609 Nonpathogen - hypothetical protein Sare_1989 1 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 159039054 Common - glycosyl transferase group 1 Sare_3514 218 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159035771 Common - hypothetical protein Sare_0098 6 None None None 159039246 Common - phage prohead protease, HK97 family Sare_3715 19 COG3740 COG3740, Phage head maturation protease General function prediction only 159040354 Nonpathogen - hypothetical protein Sare_4866 1 None None None 159036222 Common - ASPIC/UnbV domain protein Sare_0555 15 None None None 159038874 Nonpathogen - hypothetical protein Sare_3333 1 None None None 159035864 Common - major facilitator superfamily MFS_1 Sare_0191 98 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 159039306 Nonpathogen - hypothetical protein Sare_3775 1 None None None 159040577 Common - thioredoxin reductase Sare_5097 247 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 159037095 Common - two component transcriptional regulator, winged helix family Sare_1458 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159039254 Nonpathogen - hypothetical protein Sare_3723 1 None None None 159036031 Common - Taurine catabolism dioxygenase TauD/TfdA Sare_0364 22 COG2175 TauD, Probable taurine catabolism dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 159039649 Common - glutaredoxin-like protein Sare_4121 27 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 159036548 Common - transcriptional regulator, AsnC family Sare_0893 119 COG1522 Lrp, Transcriptional regulators Transcription 159036494 Common - thiamine pyrophosphate protein TPP binding domain protein Sare_0838 217 COG3961 COG3961, Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only 159037581 Nonpathogen - hypothetical protein Sare_1958 1 None None None 159038989 Common - CobB/CobQ domain protein glutamine amidotransferase Sare_3449 56 COG3442 COG3442, Predicted glutamine amidotransferase General function prediction only 159035948 Common - hypothetical protein Sare_0279 7 None None None 159037520 Common - Tetratricopeptide TPR_4 Sare_1897 18 None None None 159035867 Common - nitrate reductase molybdenum cofactor assembly chaperone Sare_0194 56 COG2180 NarJ, Nitrate reductase delta subunit Energy production and conversion 159036412 Common - cytidine deaminase Sare_0755 111 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 159036219 Common - hypothetical protein Sare_0552 10 COG0824 FcbC, Predicted thioesterase General function prediction only 159035944 Common - hypothetical protein Sare_0275 10 COG1917 COG1917, Uncharacterized conserved protein, contains double-stranded beta-helix domain Function unknown 159038752 Common - extracellular solute-binding protein family 1 Sare_3207 45 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 159038124 Common - short-chain dehydrogenase/reductase SDR Sare_2544 231 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 159039773 Common - ribosomal protein L13 Sare_4254 231 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 159039685 Common - Deoxyribonuclease V Sare_4157 73 COG1515 Nfi, Deoxyinosine 3'endonuclease (endonuclease V) DNA replication, recombination, and repair 159036690 Common - AMP-dependent synthetase and ligase Sare_1043 215 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 159037924 Common - glycosyltransferase, MGT family Sare_2328 48 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 159037719 Common - NAD-dependent epimerase/dehydratase Sare_2116 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 159036672 Common - Integrase catalytic region Sare_1024 75 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 159038760 Common - aminotransferase class-III Sare_3215 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 159039252 Nonpathogen - hypothetical protein Sare_3721 1 None None None 159037755 Nonpathogen - hypothetical protein Sare_2152 1 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159039490 Common - hypothetical protein Sare_3962 8 None None None 159036043 Common - glycine cleavage T protein (aminomethyl transferase) Sare_0376 47 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 159038500 Common - Peroxidase Sare_2936 15 None None None 159038482 Common - DGPFAETKE family protein Sare_2918 31 COG3795 COG3795, Uncharacterized protein conserved in bacteria Function unknown 159038105 Common - protein of unknown function DUF881 Sare_2524 22 COG3879 COG3879, Uncharacterized protein conserved in bacteria Function unknown 159036402 Common - alpha amylase catalytic region Sare_0745 162 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 159037588 Nonpathogen - hypothetical protein Sare_1965 1 None None None 159038710 Common - hypothetical protein Sare_3164 40 COG4188 COG4188, Predicted dienelactone hydrolase General function prediction only 159036979 Common - peptidase M16 domain protein Sare_1340 201 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 159038947 Common - ABC transporter related Sare_3407 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 159037538 Common - tyrosine recombinase XerD Sare_1915 206 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 159037359 Common - hypothetical protein Sare_1734 18 None None None 159035958 Common - transcriptional regulator, DeoR family Sare_0289 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 159037400 Common - Phosphatidylinositol alpha-mannosyltransferase Sare_1775 163 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159037766 Nonpathogen - hypothetical protein Sare_2164 1 None None None 159035718 Common - peptidase S8 and S53 subtilisin kexin sedolisin Sare_0044 87 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 159037284 Common - Na+/H+ antiporter NhaA Sare_1658 143 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 159037743 Common - NIPSNAP family containing protein Sare_2140 4 None None None 159037141 Common - binding-protein-dependent transport systems inner membrane component Sare_1507 146 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 159037882 Common - NmrA family protein Sare_2286 5 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 159037380 Common - glycoside hydrolase family 3 domain protein Sare_1755 180 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 159040392 Common - Haloacid dehalogenase domain protein hydrolase Sare_4905 37 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 159037267 Nonpathogen - hypothetical protein Sare_1637 1 None None None 159040497 Common - flavin reductase domain protein FMN-binding Sare_5016 23 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 159037352 Common - ATP-dependent helicase HrpB Sare_1727 131 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 159037056 Common - Beta-lactamase Sare_1418 61 COG2367 PenP, Beta-lactamase class A Defense mechanisms 159037803 Common - 6-phosphogluconate dehydrogenase NAD-binding Sare_2204 165 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 159039430 Common - Acetaldehyde dehydrogenase Sare_3901 37 COG4569 MhpF, Acetaldehyde dehydrogenase (acetylating) Secondary metabolites biosynthesis, transport, and catabolism 159039108 Common - glutamine synthetase, type I Sare_3568 224 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 159040263 Nonpathogen - hypothetical protein Sare_4772 1 None None None 159039156 Common - Acyl transferase Sare_3620 206 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 159039423 Nonpathogen - hypothetical protein Sare_3894 1 None None None 159040335 Common - phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2 Sare_4847 64 COG4668 MtlA, Mannitol/fructose-specific phosphotransferase system, IIA domain Carbohydrate transport and metabolism 159038144 Common - Ion transport 2 domain protein Sare_2564 36 COG1226 Kch, Kef-type K+ transport systems, predicted NAD-binding component Inorganic ion transport and metabolism 159035921 Nonpathogen - hypothetical protein Sare_0251 1 None None None 159037309 Common - oxidoreductase domain protein Sare_1684 168 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 159039052 Common - protein of unknown function DUF574 Sare_3512 12 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 159037407 Common - two component transcriptional regulator, LuxR family Sare_1782 217 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159036384 Common - 4-diphosphocytidyl-2C-methyl-D-erythritol kinase Sare_0727 179 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 159038700 Common - Beta-ketoacyl synthase Sare_3154 212 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159036523 Nonpathogen - hypothetical protein Sare_0867 1 None None None 159036519 Common - Cystathionine gamma-synthase Sare_0863 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 159036103 Common - Tetratricopeptide domain protein Sare_0436 13 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 159037224 Common - regulator of chromosome condensation RCC1 Sare_1593 61 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 159040477 Common - Peptidylprolyl isomerase Sare_4996 167 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 159038327 Common - hypothetical protein Sare_2754 7 COG3222 COG3222, Uncharacterized protein conserved in bacteria Function unknown 159038926 Common - lipase class 2 Sare_3386 35 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 159037736 Nonpathogen - hypothetical protein Sare_2133 1 None None None 159036166 Common - hypothetical protein Sare_0499 4 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 159035687 Nonpathogen - hypothetical protein Sare_0013 1 COG3122 COG3122, Uncharacterized protein conserved in bacteria Function unknown 159038503 Common - ABC-2 type transporter Sare_2939 113 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 159036812 Common - GCN5-related N-acetyltransferase Sare_1166 79 COG0456 RimI, Acetyltransferases General function prediction only 159040524 Nonpathogen - hypothetical protein Sare_5043 2 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 159040579 Common - cell wall hydrolase/autolysin Sare_5099 162 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 159037849 Nonpathogen - hypothetical protein Sare_2251 1 None None None 159037515 Common - UspA domain protein Sare_1892 71 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 159039960 Common - transcriptional regulator, IclR family Sare_4448 37 COG1414 IclR, Transcriptional regulator Transcription 159036945 Common - short-chain dehydrogenase/reductase SDR Sare_1306 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159038862 Common - 6-phosphogluconolactonase Sare_3321 73 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 159039061 Common - Nucleotidyl transferase Sare_3521 112 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 159038961 Common - histidinol-phosphate aminotransferase Sare_3421 222 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 159040425 Common - Adenosylmethionine--8-amino-7-oxononanoate transaminase Sare_4941 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 159036181 Common - Aldose 1-epimerase Sare_0514 42 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 159040556 Nonpathogen - hypothetical protein Sare_5075 1 None None None 159039573 Common - rRNA (adenine-N(6)-)-methyltransferase Sare_4045 57 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 159038190 Common - Methyltransferase type 11 Sare_2612 30 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159040538 Common - MoeA domain protein domain I and II Sare_5057 194 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 159037089 Common - hypothetical protein Sare_1452 43 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 159040504 Common - Glycerophosphodiester phosphodiesterase Sare_5023 167 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 159036819 Common - hypothetical protein Sare_1173 15 None None None 159039670 Common - GCN5-related N-acetyltransferase Sare_4142 15 COG0456 RimI, Acetyltransferases General function prediction only 159038262 Common - Carbamoyl-phosphate synthase L chain ATP-binding Sare_2687 227 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 159038223 Nonpathogen - hypothetical protein Sare_2648 1 None None None 159039939 Nonpathogen - hypothetical protein Sare_4424 1 None None None 159037718 Common - Activator of Hsp90 ATPase 1 family protein Sare_2115 51 COG3832 COG3832, Uncharacterized conserved protein Function unknown 159035704 Common - transcriptional regulator, TetR family Sare_0030 50 COG1309 AcrR, Transcriptional regulator Transcription 159036870 Common - aminoglycoside phosphotransferase Sare_1225 6 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 159039410 Nonpathogen - hypothetical protein Sare_3881 1 None None None 159039598 Common - 2-oxoglutarate dehydrogenase, E1 subunit Sare_4070 194 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 159038835 Nonpathogen - hypothetical protein Sare_3294 1 COG4907 COG4907, Predicted membrane protein Function unknown 159036045 Common - L-asparaginase II Sare_0378 46 COG4448 AnsA, L-asparaginase II Amino acid transport and metabolism 159037690 Common - Sphingomyelin phosphodiesterase Sare_2087 9 COG3568 ElsH, Metal-dependent hydrolase General function prediction only 159037977 Common - Lysine 2,3-aminomutase Sare_2381 125 COG1509 KamA, Lysine 2,3-aminomutase Amino acid transport and metabolism 159039707 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Sare_4180 249 COG1123 COG1123, ATPase components of various ABC-type transport systems, contain duplicated ATPase General function prediction only 159036024 Nonpathogen - Lantibiotic dehydratase domain protein Sare_0356 5 None None None 159036279 Nonpathogen - hypothetical protein Sare_0613 1 None None None 159037966 Common - sec-independent translocation protein mttA/Hcf106 Sare_2370 7 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 159040470 Common - histidine kinase Sare_4989 117 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159039974 Common - NADH-quinone oxidoreductase, B subunit Sare_4462 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 159037048 Common - ATP-cone domain protein Sare_1410 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 159036699 Common - Oxidoreductase FAD-binding domain protein Sare_1052 166 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 159039983 Common - phenylacetate-CoA oxygenase, PaaH subunit Sare_4471 38 COG3460 COG3460, Uncharacterized enzyme of phenylacetate metabolism Secondary metabolites biosynthesis, transport, and catabolism 159036191 Common - beta-phosphoglucomutase family hydrolase Sare_0524 105 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 159039812 Common - methionine aminopeptidase, type I Sare_4293 233 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 159036510 Common - protein of unknown function DUF1232 Sare_0854 2 COG3339 COG3339, Uncharacterized conserved protein Function unknown 159038910 Common - Methyltransferase type 11 Sare_3370 153 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159039588 Common - glycosyl transferase group 1 Sare_4060 121 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159037921 Common - methionine synthase Sare_2325 178 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 159036419 Common - protein of unknown function DUF742 Sare_0762 9 None None None 159036791 Common - tryptophanyl-tRNA synthetase Sare_1145 249 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159037210 Nonpathogen - hypothetical protein Sare_1576 1 None None None 159038608 Common - flavin reductase domain protein FMN-binding Sare_3051 108 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 159039243 Nonpathogen - hypothetical protein Sare_3712 1 None None None 159037814 Common - von Willebrand factor type A Sare_2216 23 COG2304 COG2304, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 159040217 Common - glycine betaine/L-proline ABC transporter, ATPase subunit Sare_4726 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 159039177 Nonpathogen - transcriptional regulator, LysR family Sare_3641 1 COG0583 LysR, Transcriptional regulator Transcription 159036135 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Sare_0468 180 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 159037615 Common - major facilitator superfamily MFS_1 Sare_2001 43 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159039444 Common - hypothetical protein Sare_3915 5 None None None 159037179 Nonpathogen - hypothetical protein Sare_1545 1 None None None 159037299 Common - hypothetical protein Sare_1673 5 None None None 159040456 Nonpathogen - SAF domain protein Sare_4972 7 COG1261 FlgA, Flagellar basal body P-ring biosynthesis protein Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 159038228 Common - Aminoglycoside N(3')-acetyltransferase Sare_2653 20 COG2746 COG2746, Aminoglycoside N3'-acetyltransferase Defense mechanisms 159039483 Nonpathogen - hypothetical protein Sare_3955 4 None None None 159035951 Common - amine oxidase Sare_0282 13 COG3349 COG3349, Uncharacterized conserved protein Function unknown 159035856 Common - Abortive infection protein Sare_0183 2 None None None 159038321 Nonpathogen - hypothetical protein Sare_2748 8 COG0392 COG0392, Predicted integral membrane protein Function unknown 159037834 Common - DNA primase small subunit Sare_2236 66 COG3285 COG3285, Predicted eukaryotic-type DNA primase DNA replication, recombination, and repair 159039203 Common - transcriptional regulator, MerR family Sare_3670 104 COG0789 SoxR, Predicted transcriptional regulators Transcription 159039338 Common - Beta-N-acetylhexosaminidase Sare_3807 58 COG3525 Chb, N-acetyl-beta-hexosaminidase Carbohydrate transport and metabolism 159039346 Common - ABC transporter related Sare_3815 249 COG1121 ZnuC, ABC-type Mn/Zn transport systems, ATPase component Inorganic ion transport and metabolism 159038199 Common - LPXTG-motif cell wall anchor domain Sare_2621 4 None None None 159039384 Common - iojap-like protein Sare_3853 144 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 159038571 Common - pyruvate phosphate dikinase PEP/pyruvate-binding Sare_3009 143 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 159036828 Nonpathogen - HAD-superfamily hydrolase, subfamily IA, variant 3 Sare_1182 2 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 159036093 Common - glutamyl-tRNA reductase Sare_0426 180 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 159039749 Common - oxidoreductase molybdopterin binding Sare_4230 127 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 159038368 Common - Radical SAM domain protein Sare_2795 100 COG1964 COG1964, Predicted Fe-S oxidoreductases General function prediction only 159039059 Common - (p)ppGpp synthetase I, SpoT/RelA Sare_3519 207 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 159039818 Common - ribosomal protein L18 Sare_4299 212 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 159039537 Common - hypothetical protein Sare_4009 13 None None None 159040563 Common - GCN5-related N-acetyltransferase Sare_5083 37 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 159036339 Common - hypothetical protein Sare_0680 14 COG2223 NarK, Nitrate/nitrite transporter Inorganic ion transport and metabolism 159037606 Nonpathogen - hypothetical protein Sare_1986 1 None None None 159038982 Common - UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase Sare_3442 212 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 159038957 Nonpathogen - hypothetical protein Sare_3417 1 None None None 159038158 Common - CRISPR-associated protein Cas1 Sare_2578 46 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 159040429 Common - aminotransferase class-III Sare_4945 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 159037674 Common - Methyltransferase type 12 Sare_2070 4 COG5459 COG5459, Predicted rRNA methylase Translation, ribosomal structure and biogenesis 159038919 Common - transcriptional regulator, AsnC family Sare_3379 140 COG1522 Lrp, Transcriptional regulators Transcription 159037475 Common - orotidine 5'-phosphate decarboxylase Sare_1852 65 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 159039524 Common - hypothetical protein Sare_3996 15 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 159035914 Common - Activator of Hsp90 ATPase 1 family protein Sare_0242 17 COG3832 COG3832, Uncharacterized conserved protein Function unknown 159035776 Common - major facilitator superfamily MFS_1 Sare_0103 164 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159037072 Common - PfkB domain protein Sare_1435 150 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 159038553 Common - hypothetical protein Sare_2991 4 None None None 159037516 Common - GCN5-related N-acetyltransferase Sare_1893 13 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 159036799 Common - Polyphosphate kinase Sare_1153 162 COG0855 Ppk, Polyphosphate kinase Inorganic ion transport and metabolism 159039449 Common - uroporphyrin-III C-methyltransferase Sare_3920 199 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 159036757 Common - glutamyl-tRNA(Gln) amidotransferase, C subunit Sare_1111 131 COG0721 GatC, Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit Translation, ribosomal structure and biogenesis 159035907 Nonpathogen - hypothetical protein Sare_0234 1 None None None 159039820 Common - ribosomal protein S8 Sare_4301 238 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 159035983 Common - FAD dependent oxidoreductase Sare_0315 149 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 159037501 Common - tRNA/rRNA methyltransferase (SpoU) Sare_1878 109 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 159036417 Common - histidine kinase Sare_0760 51 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159039827 Common - ribosomal protein L16 Sare_4308 218 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 159038295 Nonpathogen - hypothetical protein Sare_2720 1 None None None 159035817 Common - transcriptional regulator, TetR family Sare_0144 105 COG1309 AcrR, Transcriptional regulator Transcription 159036594 Common - protein of unknown function DUF690 Sare_0941 8 None None None 159035895 Common - ABC transporter related Sare_0222 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 159038707 Common - IstB domain protein ATP-binding protein Sare_3161 98 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 159037060 Common - histone deacetylase superfamily Sare_1422 159 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 159038648 Common - transcriptional regulator, SARP family Sare_3099 23 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 159038841 Common - hypothetical protein Sare_3300 10 None None None 159036363 Common - lipase class 2 Sare_0706 37 COG1075 LipA, Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold General function prediction only 159038038 Common - transcriptional regulator, XRE family Sare_2453 16 COG1396 HipB, Predicted transcriptional regulators Transcription 159037599 Common - CRISPR-associated protein, Cse3 family Sare_1976 18 None None None 159037168 Common - UspA domain protein Sare_1534 14 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 159036787 Common - transcriptional regulator, TetR family Sare_1141 7 COG1309 AcrR, Transcriptional regulator Transcription 159038588 Nonpathogen - hypothetical protein Sare_3028 1 None None None 159040424 Common - Epoxide hydrolase domain protein Sare_4940 36 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159036607 Nonpathogen - copper resistance D domain protein Sare_0957 1 COG1276 PcoD, Putative copper export protein Inorganic ion transport and metabolism 159039796 Common - thiazole biosynthesis family protein Sare_4277 166 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 159039289 Nonpathogen - hypothetical protein Sare_3758 1 None None None 159040146 Common - regulator of chromosome condensation, RCC1 Sare_4652 43 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 159036001 Common - phosphate ABC transporter, ATPase subunit Sare_0333 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 159038035 Nonpathogen - UbiC transcription regulator-associated domain protein Sare_2450 2 COG2188 PhnF, Transcriptional regulators Transcription 159037290 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Sare_1664 249 COG0444 DppD, ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component Amino acid transport and metabolism / Inorganic ion transport and metabolism 159037960 Common - protein of unknown function DUF245 domain protein Sare_2364 16 None None None 159038686 Common - nitrate reductase molybdenum cofactor assembly chaperone Sare_3140 25 COG2180 NarJ, Nitrate reductase delta subunit Energy production and conversion 159039174 Common - Alcohol dehydrogenase GroES domain protein Sare_3638 140 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 159035844 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Sare_0171 12 COG3576 COG3576, Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase General function prediction only 159038337 Nonpathogen - hypothetical protein Sare_2764 3 COG5401 COG5401, Spore germination protein General function prediction only 159038314 Nonpathogen - periplasmic binding protein Sare_2741 4 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 159039180 Common - Substrate-binding region of ABC-type glycine betaine transport system Sare_3644 59 COG2113 ProX, ABC-type proline/glycine betaine transport systems, periplasmic components Amino acid transport and metabolism 159038720 Common - transcriptional regulator, ArsR family Sare_3175 124 COG0640 ArsR, Predicted transcriptional regulators Transcription 159040135 Nonpathogen - hypothetical protein Sare_4640 3 None None None 159036838 Common - prolyl-tRNA synthetase Sare_1192 237 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159039233 Nonpathogen - hypothetical protein Sare_3702 1 None None None 159039029 Common - transcriptional regulator, LacI family Sare_3489 126 COG1609 PurR, Transcriptional regulators Transcription 159038445 Common - hypothetical protein Sare_2881 5 None None None 159037182 Common - protein of unknown function DUF397 Sare_1548 6 None None None 159039369 Common - putative oxygen-independent coproporphyrinogen III oxidase Sare_3838 203 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 159038904 Common - Antibiotic biosynthesis monooxygenase Sare_3364 30 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 159038937 Common - Indole-3-glycerol-phosphate synthase Sare_3397 218 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 159038389 Common - acyl-CoA dehydrogenase domain protein Sare_2816 135 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159040569 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sare_5089 8 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159036802 Common - phospholipid/glycerol acyltransferase Sare_1156 83 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 159037702 Common - monooxygenase FAD-binding Sare_2099 23 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 159038821 Nonpathogen - Lantibiotic dehydratase domain protein Sare_3280 4 None None None 159035937 Common - diguanylate cyclase with GAF sensor Sare_0267 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 159037797 Common - NADP oxidoreductase coenzyme F420-dependent Sare_2198 20 COG2085 COG2085, Predicted dinucleotide-binding enzymes General function prediction only 159038627 Common - histidine kinase Sare_3071 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159037412 Common - helix-turn-helix domain protein Sare_1787 6 None None None 159040205 Common - nicotinate-nucleotide pyrophosphorylase Sare_4714 199 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 159038642 Common - serine/threonine protein kinase Sare_3091 20 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 159037250 Common - Substrate-binding region of ABC-type glycine betaine transport system Sare_1620 90 COG1732 OpuBC, Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) Cell envelope biogenesis, outer membrane 159038230 Nonpathogen - hypothetical protein Sare_2655 1 None None None 159039730 Common - binding-protein-dependent transport systems inner membrane component Sare_4211 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 159036728 Common - binding-protein-dependent transport systems inner membrane component Sare_1082 143 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 159037951 Common - tRNA methyltransferase complex GCD14 subunit Sare_2355 59 COG2519 GCD14, tRNA(1-methyladenosine) methyltransferase and related methyltransferases Translation, ribosomal structure and biogenesis 159039167 Common - cation diffusion facilitator family transporter Sare_3631 172 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 159040309 Common - alpha/beta hydrolase fold Sare_4821 155 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159036423 Common - ABC transporter CydDC cysteine exporter (CydDC-E) family permease/ATP-binding protein CydC Sare_0766 244 COG4987 CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 159038930 Common - hypothetical protein Sare_3390 16 None None None 159040340 Common - transcriptional regulator, LuxR family Sare_4852 78 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159035883 Nonpathogen - hypothetical protein Sare_0210 1 None None None 159035926 Common - binding-protein-dependent transport systems inner membrane component Sare_0256 218 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 159039321 Nonpathogen - hypothetical protein Sare_3790 1 None None None 159039988 Nonpathogen - hypothetical protein Sare_4476 3 None None None 159036663 Common - nuclear export factor GLE1 Sare_1014 28 COG4549 COG4549, Uncharacterized protein conserved in bacteria Function unknown 159037988 Nonpathogen - hypothetical protein Sare_2392 1 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 159035761 Common - putative phosphohistidine phosphatase, SixA Sare_0088 27 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 159036654 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Sare_1005 218 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 159039511 Common - glycoside hydrolase family 6 Sare_3983 18 COG5297 CelA, Cellobiohydrolase A (1,4-beta-cellobiosidase A) Carbohydrate transport and metabolism 159036537 Common - glycosyl transferase group 1 Sare_0881 166 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159036341 Common - multiple antibiotic resistance (MarC)-related protein Sare_0682 100 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 159038055 Nonpathogen - hypothetical protein Sare_2473 1 None None None 159040017 Nonpathogen - hypothetical protein Sare_4507 1 COG5373 COG5373, Predicted membrane protein Function unknown 159040010 Common - transport system permease protein Sare_4500 190 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 159037245 Nonpathogen - hypothetical protein Sare_1614 3 None None None 159038394 Common - protein of unknown function DUF35 Sare_2821 34 COG1545 COG1545, Predicted nucleic-acid-binding protein containing a Zn-ribbon General function prediction only 159038135 Common - pentapeptide repeat protein Sare_2555 9 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 159039362 Common - protein of unknown function UPF0054 Sare_3831 125 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 159037392 Common - histidine kinase Sare_1767 177 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159040054 Common - hypothetical protein Sare_4548 7 None None None 159036221 Common - cytochrome P450 Sare_0554 81 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159035834 Nonpathogen - hypothetical protein Sare_0161 1 None None None 159039965 Common - NADH-ubiquinone oxidoreductase chain 4L Sare_4453 143 COG0713 NuoK, NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) Energy production and conversion 159037065 Common - methyltransferase small Sare_1428 25 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 159039099 Common - hypothetical protein Sare_3559 7 COG5617 COG5617, Predicted integral membrane protein Function unknown 159037418 Common - inner-membrane translocator Sare_1794 143 COG0559 LivH, Branched-chain amino acid ABC-type transport system, permease components Amino acid transport and metabolism 159037124 Common - TAP domain protein Sare_1488 34 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159036115 Nonpathogen - transcriptional regulator, XRE family Sare_0448 1 COG1396 HipB, Predicted transcriptional regulators Transcription 159038411 Common - AMP-dependent synthetase and ligase Sare_2838 213 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159036178 Common - Citrate (Si)-synthase Sare_0511 192 COG0372 GltA, Citrate synthase Energy production and conversion 159039553 Common - diguanylate cyclase Sare_4025 176 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 159038252 Common - Beta-ketoacyl synthase Sare_2677 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159037217 Nonpathogen - hypothetical protein Sare_1585 1 None None None 159037722 Common - tryptophan halogenase Sare_2119 49 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 159039155 Common - putative transcriptional regulator, PucR family Sare_3619 30 COG2508 COG2508, Regulator of polyketide synthase expression Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism 159037844 Common - hypothetical protein Sare_2246 53 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 159039349 Nonpathogen - hypothetical protein Sare_3818 1 None None None 159038462 Common - transcriptional regulator, AraC family Sare_2898 34 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 159036616 Common - FAD linked oxidase domain protein Sare_0966 32 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 159039896 Common - Helix-turn-helix type 11 domain protein Sare_4377 20 COG2378 COG2378, Predicted transcriptional regulator Transcription 159038134 Common - hypothetical protein Sare_2554 15 None None None 159040085 Nonpathogen - hypothetical protein Sare_4581 1 None None None 159036843 Common - tRNA (guanine-N1)-methyltransferase Sare_1197 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 159039308 Nonpathogen - hypothetical protein Sare_3777 1 None None None 159037801 Common - Catalase Sare_2202 125 COG0753 KatE, Catalase Inorganic ion transport and metabolism 159039809 Common - ribosomal protein L36 Sare_4290 133 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 159040126 Common - NLP/P60 protein Sare_4630 95 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 159039401 Common - FolC bifunctional protein Sare_3871 215 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 159037635 Common - protein of unknown function DUF323 Sare_2027 105 COG1262 COG1262, Uncharacterized conserved protein Function unknown 159040151 Common - transcriptional regulator, IclR family Sare_4660 37 COG1414 IclR, Transcriptional regulator Transcription 159037453 Nonpathogen - hypothetical protein Sare_1829 1 None None None 159038681 Common - GCN5-related N-acetyltransferase Sare_3135 64 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 159036902 Common - cytochrome P450 Sare_1259 86 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159039938 Common - histidine triad (HIT) protein Sare_4423 18 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 159038613 Common - acyl-CoA dehydrogenase domain protein Sare_3056 110 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159037993 Common - bifunctional deaminase-reductase domain protein Sare_2397 28 COG1985 RibD, Pyrimidine reductase, riboflavin biosynthesis Coenzyme metabolism 159037154 Common - dethiobiotin synthase Sare_1520 23 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 159039204 Common - transcriptional regulator, SARP family Sare_3671 45 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 159038418 Nonpathogen - Arylsulfatase regulator (Fe-S oxidoreductase)-like protein Sare_2845 2 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 159037396 Common - histidine triad (HIT) protein Sare_1771 107 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 159037184 Nonpathogen - hypothetical protein Sare_1550 2 None None None 159036858 Common - Bifunctional DNA primase/polymerase Sare_1213 17 None None None 159036881 Nonpathogen - hypothetical protein Sare_1238 1 None None None 159037897 Common - hypothetical protein Sare_2301 5 None None None 159039613 Common - Sulfite reductase (ferredoxin) Sare_4085 166 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 159037773 Common - NAD-dependent epimerase/dehydratase Sare_2173 233 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 159039696 Nonpathogen - hypothetical protein Sare_4169 4 None None None 159037770 Nonpathogen - hypothetical protein Sare_2168 1 None None None 159038248 Common - 4-hydroxyphenylpyruvate dioxygenase Sare_2673 77 COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins Amino acid transport and metabolism / General function prediction only 159038382 Common - acyl-CoA dehydrogenase domain protein Sare_2809 132 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159040394 Common - hypothetical protein Sare_4907 3 None None None 159039123 Common - NAD+ synthetase Sare_3585 213 COG0171 NadE, NAD synthase Coenzyme metabolism 159036123 Common - gamma-glutamyl phosphate reductase Sare_0456 187 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 159037138 Common - diguanylate phosphodiesterase Sare_1503 136 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 159040411 Common - Integrase catalytic region Sare_4926 75 COG4584 COG4584, Transposase and inactivated derivatives DNA replication, recombination, and repair 159037633 Common - NDP-hexose 23-dehydratase Sare_2025 9 None None None 159036780 Common - Endonuclease/exonuclease/phosphatase Sare_1134 15 COG3021 COG3021, Uncharacterized protein conserved in bacteria Function unknown 159037424 Common - Holliday junction DNA helicase RuvB Sare_1800 221 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 159039802 Common - methyltransferase small Sare_4283 54 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 159039715 Common - short-chain dehydrogenase/reductase SDR Sare_4196 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159037948 Common - two component transcriptional regulator, LuxR family Sare_2352 178 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159040580 Common - hypothetical protein Sare_5100 11 None None None 159040062 Nonpathogen - hypothetical protein Sare_4556 1 None None None 159038727 Common - glutamine amidotransferase class-I Sare_3182 170 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 159036272 Nonpathogen - hypothetical protein Sare_0606 3 None None None 159040292 Nonpathogen - hypothetical protein Sare_4802 1 None None None 159038641 Nonpathogen - hypothetical protein Sare_3090 4 None None None 159039509 Nonpathogen - hypothetical protein Sare_3981 1 None None None 159039787 Common - binding-protein-dependent transport systems inner membrane component Sare_4268 196 COG0600 TauC, ABC-type nitrate/sulfonate/bicarbonate transport system, permease component Inorganic ion transport and metabolism 159040513 Common - Prephenate dehydratase Sare_5032 210 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 159036313 Nonpathogen - hypothetical protein Sare_0653 1 None None None 159038650 Common - hypothetical protein Sare_3101 6 None None None 159039226 Common - transcriptional regulator, XRE family Sare_3695 14 COG1396 HipB, Predicted transcriptional regulators Transcription 159040068 Common - amino acid adenylation domain Sare_4562 220 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159039083 Common - peptidase M50 Sare_3543 13 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 159040587 Common - single-stranded nucleic acid binding R3H domain protein Sare_5107 70 COG1847 Jag, Predicted RNA-binding protein General function prediction only 159037016 Common - hypothetical protein Sare_1378 6 None None None 159038126 Common - transcriptional regulator, TetR family Sare_2546 21 COG1309 AcrR, Transcriptional regulator Transcription 159038755 Common - ATPase BadF/BadG/BcrA/BcrD type Sare_3210 22 COG2971 COG2971, Predicted N-acetylglucosamine kinase Carbohydrate transport and metabolism 159036920 Common - 3-dehydroquinate dehydratase Sare_1277 169 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 159037665 Common - NUDIX hydrolase Sare_2060 106 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 159038090 Common - hypothetical protein Sare_2509 25 None None None 159037226 Nonpathogen - hypothetical protein Sare_1595 3 None None None 159039881 Common - glycosyl transferase family 9 Sare_4362 63 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 159036338 Nonpathogen - hypothetical protein Sare_0679 1 None None None 159036736 Common - two component transcriptional regulator, winged helix family Sare_1090 207 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159039144 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Sare_3608 220 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 159038554 Nonpathogen - hypothetical protein Sare_2992 2 None None None 159036897 Common - 3-deoxy-7-phosphoheptulonate synthase Sare_1254 73 COG3200 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 159036325 Common - phenazine biosynthesis protein PhzF family Sare_0665 115 COG0384 COG0384, Predicted epimerase, PhzC/PhzF homolog General function prediction only 159038401 Common - short-chain dehydrogenase/reductase SDR Sare_2828 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159035802 Common - short-chain dehydrogenase/reductase SDR Sare_0129 231 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 159038945 Nonpathogen - hypothetical protein Sare_3405 4 None None None 159036568 Common - hypothetical protein Sare_0913 10 None None None 159038983 Common - UDP-N-acetylmuramyl-tripeptide synthetase Sare_3443 209 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 159039596 Common - ABC transporter related Sare_4068 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159039242 Nonpathogen - hypothetical protein Sare_3711 1 None None None 159039555 Common - ribosomal protein L31 Sare_4027 194 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 159036566 Nonpathogen - hypothetical protein Sare_0911 1 None None None 159036624 Common - drug resistance transporter, EmrB/QacA subfamily Sare_0974 178 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159037875 Common - histidine kinase Sare_2278 201 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159039644 Common - UBA/THIF-type NAD/FAD binding protein Sare_4116 6 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 159039487 Common - RNA polymerase, sigma 70 subunit, RpoD family Sare_3959 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 159038491 Common - ATPase associated with various cellular activities AAA_5 Sare_2927 53 COG0714 COG0714, MoxR-like ATPases General function prediction only 159039495 Common - extracellular solute-binding protein family 1 Sare_3967 49 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 159037264 Nonpathogen - hypothetical protein Sare_1634 1 None None None 159037571 Nonpathogen - hypothetical protein Sare_1948 1 None None None 159036212 Common - alkylhydroperoxidase like protein, AhpD family Sare_0545 4 COG2128 COG2128, Uncharacterized conserved protein Function unknown 159039665 Common - hypothetical protein Sare_4137 32 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 159037850 Nonpathogen - LVIVD repeat protein Sare_2253 9 COG5276 COG5276, Uncharacterized conserved protein Function unknown 159035837 Common - phosphoribosylformylglycinamidine cyclo-ligase Sare_0164 230 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 159040366 Common - alpha/beta hydrolase fold Sare_4878 91 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159037254 Common - choline dehydrogenase Sare_1624 98 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 159036192 Common - Kojibiose phosphorylase Sare_0525 50 COG1554 ATH1, Trehalose and maltose hydrolases (possible phosphorylases) Carbohydrate transport and metabolism 159037142 Common - binding-protein-dependent transport systems inner membrane component Sare_1508 144 COG0395 UgpE, ABC-type sugar transport system, permease component Carbohydrate transport and metabolism 159037094 Common - hypothetical protein Sare_1457 6 COG5617 COG5617, Predicted integral membrane protein Function unknown 159037706 Common - cytochrome P450 Sare_2103 65 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159038049 Common - pentapeptide repeat protein Sare_2466 38 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 159037562 Common - NERD domain protein Sare_1939 62 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 159039011 Nonpathogen - hypothetical protein Sare_3471 7 None None None 159037081 Common - hypothetical protein Sare_1444 3 None None None 159040253 Common - transcriptional regulator, Crp/Fnr family Sare_4762 158 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 159038771 Common - protein of unknown function DUF742 Sare_3226 9 None None None 159039968 Common - NADH dehydrogenase (quinone) Sare_4456 189 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 159039119 Common - glutamine amidotransferase class-I Sare_3581 136 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 159038489 Common - Parallel beta-helix repeat Sare_2925 17 None None None 159038531 Nonpathogen - hypothetical protein Sare_2967 1 None None None 159037685 Common - Saccharopine dehydrogenase Sare_2081 5 COG1748 LYS9, Saccharopine dehydrogenase and related proteins Amino acid transport and metabolism 159038229 Common - Radical SAM domain protein Sare_2654 20 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 159039301 Nonpathogen - hypothetical protein Sare_3770 1 None None None 159036427 Common - hypothetical protein Sare_0770 58 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 159036400 Common - ribonuclease BN Sare_0743 12 COG1295 Rbn, Predicted membrane protein Function unknown 159037532 Common - glycosyl transferase group 1 Sare_1909 144 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159035857 Common - cation diffusion facilitator family transporter Sare_0184 168 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 159037218 Nonpathogen - GCN5-related N-acetyltransferase Sare_1586 2 COG0456 RimI, Acetyltransferases General function prediction only 159038883 Common - beta-lactamase domain protein Sare_3342 204 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 159039051 Common - two component transcriptional regulator, LuxR family Sare_3511 180 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159038042 Nonpathogen - hypothetical protein Sare_2458 1 None None None 159038675 Common - major facilitator superfamily MFS_1 Sare_3129 185 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159036292 Common - hypothetical protein Sare_0631 5 None None None 159037584 Common - Creatininase Sare_1961 88 COG1402 COG1402, Uncharacterized protein, putative amidase General function prediction only 159039164 Nonpathogen - hypothetical protein Sare_3628 1 None None None 159036378 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Sare_0721 209 COG0313 COG0313, Predicted methyltransferases General function prediction only 159035999 Common - phosphate ABC transporter, inner membrane subunit PstC Sare_0331 227 COG0573 PstC, ABC-type phosphate transport system, permease component Inorganic ion transport and metabolism 159038488 Common - Scyllo-inosamine-4-phosphate amidinotransferase Sare_2924 18 COG1834 COG1834, N-Dimethylarginine dimethylaminohydrolase Amino acid transport and metabolism 159036957 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Sare_1318 191 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 159039927 Common - putative anti-sigma regulatory factor, serine/threonine protein kinase Sare_4412 5 COG2172 RsbW, Anti-sigma regulatory factor (Ser/Thr protein kinase) Signal transduction mechanisms 159040463 Common - putative transcriptional regulator Sare_4979 68 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 159039208 Common - hypothetical protein Sare_3676 2 None None None 159037952 Nonpathogen - hypothetical protein Sare_2356 2 None None None 159040036 Common - Oligopeptidase B Sare_4526 109 COG1770 PtrB, Protease II Amino acid transport and metabolism 159040079 Nonpathogen - hypothetical protein Sare_4574 2 None None None 159040342 Common - transcriptional regulator, SARP family Sare_4854 22 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 159040288 Nonpathogen - GatB/YqeY domain protein Sare_4797 2 COG1610 COG1610, Uncharacterized conserved protein Function unknown 159039315 Nonpathogen - hypothetical protein Sare_3784 1 None None None 159039781 Common - Uroporphyrinogen III synthase HEM4 Sare_4262 35 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 159039608 Common - diacylglycerol kinase catalytic region Sare_4080 34 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 159035726 Common - serine/threonine protein kinase Sare_0052 147 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 159037248 Common - asparagine synthase (glutamine-hydrolyzing) Sare_1618 194 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 159035990 Common - protein of unknown function UPF0118 Sare_0322 24 COG0628 PerM, Predicted permease General function prediction only 159038510 Common - low temperature requirement A Sare_2946 20 COG4292 COG4292, Predicted membrane protein Function unknown 159037941 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_2345 32 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 159039629 Common - histidinol-phosphate phosphatase, putative Sare_4101 199 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 159035992 Common - protein of unknown function DUF402 Sare_0324 4 COG3557 COG3557, Uncharacterized domain/protein associated with RNAses G and E Translation, ribosomal structure and biogenesis 159035807 Nonpathogen - hypothetical protein Sare_0134 1 None None None 159035785 Common - chaperone protein DnaK Sare_0112 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 159038676 Common - Asp/Glu racemase Sare_3130 43 COG4126 COG4126, Hydantoin racemase Amino acid transport and metabolism 159037100 Common - hypothetical protein Sare_1463 14 None None None 159037364 Nonpathogen - hypothetical protein Sare_1739 1 None None None 159039172 Common - ATP-dependent transcriptional regulator, MalT-like, LuxR family Sare_3636 48 COG2909 MalT, ATP-dependent transcriptional regulator Transcription 159037686 Common - Methyltransferase type 12 Sare_2082 25 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159036730 Common - glycoside hydrolase family 38 Sare_1084 47 COG0383 AMS1, Alpha-mannosidase Carbohydrate transport and metabolism 159036909 Common - oxidoreductase domain protein Sare_1266 160 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 159037758 Common - glyoxalase/bleomycin resistance protein/dioxygenase Sare_2155 47 None None None 159039620 Common - GCN5-related N-acetyltransferase Sare_4092 19 COG0456 RimI, Acetyltransferases General function prediction only 159037448 Common - transferase hexapeptide repeat containing protein Sare_1824 133 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 159039406 Common - ATP-dependent Clp protease, ATP-binding subunit ClpX Sare_3876 218 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 159038318 Common - Penicillin amidase Sare_2745 72 COG2366 COG2366, Protein related to penicillin acylase General function prediction only 159035752 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sare_0079 154 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159040542 Nonpathogen - hypothetical protein Sare_5061 2 COG4346 COG4346, Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase Posttranslational modification, protein turnover, chaperones 159036247 Common - NUDIX hydrolase Sare_0581 20 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 159039202 Nonpathogen - hypothetical protein Sare_3668 1 None None None 159038097 Common - Silent information regulator protein Sir2 Sare_2516 135 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 159040116 Common - transcriptional regulator, Crp/Fnr family Sare_4620 155 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 159036023 Common - aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain Sare_0355 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 159037329 Common - Zn-dependent hydrolase of the beta-lactamase fold-like protein Sare_1704 120 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 159039754 Common - Methyltransferase type 11 Sare_4235 90 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159038349 Common - transcriptional regulator, TetR family Sare_2776 9 COG1309 AcrR, Transcriptional regulator Transcription 159037957 Common - 20S proteasome A and B subunits Sare_2361 43 COG0638 PRE1, 20S proteasome, alpha and beta subunits Posttranslational modification, protein turnover, chaperones 159036048 Common - hypothetical protein Sare_0381 7 None None None 159040083 Nonpathogen - UspA domain protein Sare_4578 1 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 159036289 Common - polysaccharide deacetylase Sare_0628 100 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 159037648 Common - daunorubicin resistance ABC transporter ATPase subunit Sare_2042 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159038102 Common - glycine cleavage system H protein Sare_2521 182 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 159039794 Common - phosphomethylpyrimidine kinase Sare_4275 214 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 159039192 Common - major facilitator superfamily MFS_1 Sare_3656 203 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159039866 Nonpathogen - hypothetical protein Sare_4347 3 None None None 159039653 Nonpathogen - hypothetical protein Sare_4125 1 None None None 159039249 Common - phage-related terminase Sare_3718 5 None None None 159038300 Nonpathogen - hypothetical protein Sare_2727 1 None None None 159040404 Common - protein-L-isoaspartate(D-aspartate) O-methyltransferase Sare_4918 137 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 159040313 Common - hypothetical protein Sare_4825 5 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 159036630 Common - glycoside hydrolase 15-related Sare_0980 68 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 159040374 Common - coagulation factor 5/8 type domain protein Sare_4887 16 None None None 159039958 Common - transcriptional regulator, LuxR family Sare_4446 112 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159040490 Nonpathogen - peptidase A24A prepilin type IV Sare_5009 1 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 159036388 Common - transcriptional regulator, TetR family Sare_0731 107 COG1309 AcrR, Transcriptional regulator Transcription 159040324 Nonpathogen - hypothetical protein Sare_4836 1 None None None 159040235 Common - ATP-dependent metalloprotease FtsH Sare_4744 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 159038612 Common - acyl-CoA dehydrogenase domain protein Sare_3055 98 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159040484 Common - CDP-alcohol phosphatidyltransferase Sare_5003 4 None None None 159036682 Common - transcriptional regulator, TetR family Sare_1035 14 COG1309 AcrR, Transcriptional regulator Transcription 159036082 Common - NAD-dependent epimerase/dehydratase Sare_0415 24 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 159039131 Common - Phosphoglycerate mutase Sare_3595 151 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 159038634 Nonpathogen - hypothetical protein Sare_3082 1 None None None 159037038 Common - RNA modification enzyme, MiaB family Sare_1400 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 159040276 Common - serine/threonine protein kinase Sare_4785 149 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 159036480 Common - hydroxymethylbutenyl pyrophosphate reductase Sare_0824 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 159037281 Common - transcriptional regulator, XRE family Sare_1653 6 COG1395 COG1395, Predicted transcriptional regulator Transcription 159036697 Common - hypothetical protein Sare_1050 18 COG4529 COG4529, Uncharacterized protein conserved in bacteria Function unknown 159038284 Common - Magnesium chelatase Sare_2709 67 COG1239 ChlI, Mg-chelatase subunit ChlI Coenzyme metabolism 159040412 Common - transcriptional regulator, MerR family Sare_4927 11 COG0789 SoxR, Predicted transcriptional regulators Transcription 159036774 Common - hypothetical protein Sare_1128 24 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 159037561 Nonpathogen - hypothetical protein Sare_1938 2 None None None 159038534 Nonpathogen - hypothetical protein Sare_2971 1 None None None 159039058 Common - DNA polymerase III, epsilon subunit Sare_3518 227 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 159036662 Common - copper resistance protein CopC Sare_1013 20 COG1276 PcoD, Putative copper export protein Inorganic ion transport and metabolism 159037498 Common - translation initiation factor IF-3 Sare_1875 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 159036965 Common - protein of unknown function DUF448 Sare_1326 43 COG2740 COG2740, Predicted nucleic-acid-binding protein implicated in transcription termination Transcription 159038792 Common - short-chain dehydrogenase/reductase SDR Sare_3250 216 COG0623 FabI, Enoyl- acyl-carrier-protein 159038657 Common - Fibronectin type III domain protein Sare_3111 7 None None None 159038950 Common - transcriptional regulator, GntR family with aminotransferase domain Sare_3410 223 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 159038020 Nonpathogen - hypothetical protein Sare_2427 1 COG3224 COG3224, Uncharacterized protein conserved in bacteria Function unknown 159036418 Common - Roadblock/LC7 family protein Sare_0761 11 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 159039221 Common - transcriptional regulator, XRE family Sare_3690 6 COG1396 HipB, Predicted transcriptional regulators Transcription 159036199 Common - YibE/F family protein Sare_0532 22 COG5438 COG5438, Predicted multitransmembrane protein Function unknown 159036637 Common - hypothetical protein Sare_0988 15 None None None 159040051 Common - Oxidoreductase FAD-binding domain protein Sare_4541 128 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 159037901 Nonpathogen - hypothetical protein Sare_2305 1 None None None 159037147 Common - GCN5-related N-acetyltransferase Sare_1513 9 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 159039697 Common - ABC transporter related Sare_4170 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159038728 Common - flavodoxin/nitric oxide synthase Sare_3183 115 COG0655 WrbA, Multimeric flavodoxin WrbA General function prediction only 159039399 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_3869 2 COG2514 COG2514, Predicted ring-cleavage extradiol dioxygenase General function prediction only 159039748 Common - two component transcriptional regulator, LuxR family Sare_4229 123 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159039352 Common - hypothetical protein Sare_3821 18 COG4721 COG4721, Predicted membrane protein Function unknown 159039830 Common - ribosomal protein S19 Sare_4311 242 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 159036478 Nonpathogen - Exonuclease VII small subunit Sare_0822 1 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 159040291 Nonpathogen - hypothetical protein Sare_4801 1 None None None 159038340 Nonpathogen - anti-sigma-factor antagonist Sare_2767 1 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 159036875 Common - translation elongation factor Ts Sare_1231 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 159040196 Nonpathogen - hypothetical protein Sare_4705 2 None None None 159038742 Common - alpha/beta hydrolase fold Sare_3197 134 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159036268 Common - Lantibiotic dehydratase domain protein Sare_0602 7 None None None 159035829 Common - peptidase S1 and S6 chymotrypsin/Hap Sare_0156 12 COG5640 COG5640, Secreted trypsin-like serine protease Posttranslational modification, protein turnover, chaperones 159038186 Common - hypothetical protein Sare_2608 12 COG4270 COG4270, Predicted membrane protein Function unknown 159037432 Common - beta-lactamase domain protein Sare_1808 213 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 159037423 Common - Holliday junction DNA helicase RuvA Sare_1799 204 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 159038265 Common - Polyketide synthesis cyclase Sare_2690 4 None None None 159036918 Common - ROK family protein Sare_1275 73 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 159038609 Common - amino acid adenylation domain Sare_3052 217 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159036958 Common - methionine aminopeptidase, type I Sare_1319 249 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 159036230 Common - PfkB domain protein Sare_0564 19 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 159037198 Nonpathogen - hypothetical protein Sare_1564 1 None None None 159039721 Common - succinyl-CoA synthetase, alpha subunit Sare_4202 215 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 159037553 Nonpathogen - hypothetical protein Sare_1930 1 None None None 159036674 Nonpathogen - hypothetical protein Sare_1026 1 None None None 159036405 Common - binding-protein-dependent transport systems inner membrane component Sare_0748 147 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 159038068 Nonpathogen - hypothetical protein Sare_2487 1 None None None 159036308 Common - NADH-ubiquinone/plastoquinone oxidoreductase chain 3 Sare_0648 118 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 159039589 Common - transport-associated Sare_4061 24 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 159040458 Nonpathogen - hypothetical protein Sare_4974 1 None None None 159039048 Common - cyclase/dehydrase Sare_3508 8 None None None 159040506 Common - putative signal transduction histidine kinase Sare_5025 6 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 159040207 Nonpathogen - hypothetical protein Sare_4716 1 None None None 159037964 Common - hypothetical protein Sare_2368 39 COG2378 COG2378, Predicted transcriptional regulator Transcription 159037972 Common - peptidase M24 Sare_2376 239 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 159037586 Common - amino acid permease-associated region Sare_1963 179 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 159039316 Nonpathogen - hypothetical protein Sare_3785 1 None None None 159036420 Common - protein of unknown function ATP binding Sare_0763 32 COG2229 COG2229, Predicted GTPase General function prediction only 159035794 Common - hypothetical protein Sare_0121 7 None None None 159040529 Common - metallophosphoesterase Sare_5048 104 COG1408 COG1408, Predicted phosphohydrolases General function prediction only 159036409 Common - ABC transporter related Sare_0752 249 COG3845 COG3845, ABC-type uncharacterized transport systems, ATPase components General function prediction only 159037324 Common - phosphoglucomutase, alpha-D-glucose phosphate-specific Sare_1699 213 COG0033 Pgm, Phosphoglucomutase Carbohydrate transport and metabolism 159038917 Common - Extracellular ligand-binding receptor Sare_3377 134 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 159038208 Common - extracellular solute-binding protein family 1 Sare_2631 89 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 159037049 Common - ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent Sare_1411 222 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 159036642 Common - glycosyl transferase group 1 Sare_0993 121 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159038749 Common - DNA-directed DNA polymerase Sare_3204 13 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 159038214 Common - glycoside hydrolase 15-related Sare_2637 68 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 159036532 Common - acyl-CoA dehydrogenase domain protein Sare_0876 163 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159039634 Common - ribose-phosphate pyrophosphokinase Sare_4106 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 159038765 Common - Asparaginase/glutaminase Sare_3220 86 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 159038783 Common - cytochrome P450 Sare_3241 70 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159038804 Common - chitin-binding domain 3 protein Sare_3263 26 COG3397 COG3397, Uncharacterized protein conserved in bacteria Function unknown 159038366 Common - cobalamin biosynthesis protein CbiM Sare_2793 74 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 159037378 Common - hypothetical protein Sare_1753 44 COG3569 COG3569, Topoisomerase IB DNA replication, recombination, and repair 159038473 Common - Appr-1-p processing domain protein Sare_2909 114 COG2110 COG2110, Predicted phosphatase homologous to the C-terminal domain of histone macroH2A1 General function prediction only 159036805 Common - protein of unknown function DUF397 Sare_1159 6 None None None 159036556 Common - cation diffusion facilitator family transporter Sare_0901 52 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 159037002 Common - Formamidopyrimidine-DNA glycolase, H2TH DNA binding Sare_1363 178 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 159038687 Common - respiratory nitrate reductase, gamma subunit Sare_3141 59 COG2181 NarI, Nitrate reductase gamma subunit Energy production and conversion 159037451 Nonpathogen - hypothetical protein Sare_1827 2 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 159040177 Common - fumarylacetoacetase Sare_4686 48 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 159039851 Common - MaoC domain protein dehydratase Sare_4332 29 COG2030 MaoC, Acyl dehydratase Lipid metabolism 159038087 Common - hypothetical protein Sare_2506 2 None None None 159039875 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Sare_4356 155 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 159036357 Common - Roadblock/LC7 family protein Sare_0700 10 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 159036301 Nonpathogen - hypothetical protein Sare_0641 1 None None None 159037028 Common - regulatory protein RecX Sare_1390 15 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 159039539 Common - cell envelope-related transcriptional attenuator Sare_4011 60 COG1316 LytR, Transcriptional regulator Transcription 159038278 Common - precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit Sare_2703 61 COG2242 CobL, Precorrin-6B methylase 2 Coenzyme metabolism 159040438 Common - FAD linked oxidase domain protein Sare_4954 93 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 159038203 Common - hypothetical protein Sare_2625 4 None None None 159037439 Common - AAA ATPase central domain protein Sare_1815 244 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 159037984 Common - apolipoprotein N-acyltransferase Sare_2388 149 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 159040304 Common - hypothetical protein Sare_4816 4 None None None 159040558 Common - glycosyl transferase family 51 Sare_5078 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 159039018 Common - Polyprenyl synthetase Sare_3478 238 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 159035824 Common - UbiC transcription regulator-associated domain protein Sare_0151 5 COG2188 PhnF, Transcriptional regulators Transcription 159039911 Nonpathogen - hypothetical protein Sare_4396 1 None None None 159037382 Common - hypothetical protein Sare_1757 3 None None None 159035705 Common - Carbamoyl-phosphate synthase L chain ATP-binding Sare_0031 225 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 159038372 Common - Alcohol dehydrogenase GroES domain protein Sare_2799 150 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 159037488 Common - Ribulose-phosphate 3-epimerase Sare_1865 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 159036655 Common - cobalamin (vitamin B12) biosynthesis CbiM protein Sare_1006 41 COG0310 CbiM, ABC-type Co2+ transport system, permease component Inorganic ion transport and metabolism 159036996 Common - transcriptional regulator, XRE family Sare_1357 28 COG1396 HipB, Predicted transcriptional regulators Transcription 159038973 Common - hypothetical protein Sare_3433 17 None None None 159039334 Common - choline/carnitine/betaine transporter Sare_3803 96 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 159038773 Common - putative sensor with HAMP domain Sare_3228 26 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 159037855 Common - hypothetical protein Sare_2258 42 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 159036496 Nonpathogen - hypothetical protein Sare_0840 1 None None None 159037040 Common - hypothetical protein Sare_1402 8 COG3885 COG3885, Uncharacterized conserved protein Function unknown 159039260 Common - phage/plasmid primase, P4 family Sare_3729 44 COG3378 COG3378, Predicted ATPase General function prediction only 159037678 Common - binding-protein-dependent transport systems inner membrane component Sare_2074 20 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 159038696 Nonpathogen - hypothetical protein Sare_3150 2 None None None 159036647 Common - formiminoglutamate deiminase Sare_0998 138 COG0402 SsnA, Cytosine deaminase and related metal-dependent hydrolases Nucleotide transport and metabolism / General function prediction only 159040164 Nonpathogen - hypothetical protein Sare_4673 1 None None None 159036395 Common - sulfate adenylyltransferase, large subunit Sare_0738 249 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 159037007 Common - protein of unknown function DUF21 Sare_1368 212 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 159040175 Nonpathogen - hypothetical protein Sare_4684 3 COG3832 COG3832, Uncharacterized conserved protein Function unknown 159036524 Common - LmbE family protein Sare_0868 28 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 159040241 Common - D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase Sare_4750 91 COG2027 DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) Cell envelope biogenesis, outer membrane 159035788 Common - transcriptional regulator, MerR family Sare_0115 56 COG0789 SoxR, Predicted transcriptional regulators Transcription 159039564 Common - hypothetical protein Sare_4036 12 None None None 159040345 Common - histidine kinase Sare_4857 134 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159037641 Common - protein of unknown function DUF1205 Sare_2033 8 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 159037109 Common - hypothetical protein Sare_1473 19 None None None 159038393 Common - hypothetical protein Sare_2820 12 None None None 159037353 Common - protein of unknown function DUF397 Sare_1728 5 None None None 159039627 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Sare_4099 226 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 159040591 Common - ribosomal protein L34 Sare_5111 193 None None None 159037461 Common - Chorismate synthase Sare_1838 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 159040093 Common - hypothetical protein Sare_4595 11 None None None 159038506 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_2942 18 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 159037467 Common - transcriptional regulator, XRE family Sare_1844 7 COG1396 HipB, Predicted transcriptional regulators Transcription 159039673 Common - LmbE family protein Sare_4145 27 COG2120 COG2120, Uncharacterized proteins, LmbE homologs Function unknown 159038857 Common - transketolase Sare_3316 220 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 159038172 Common - transcriptional regulator, LuxR family Sare_2593 8 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159036487 Common - MazG family protein Sare_0831 154 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 159038027 Common - Endoribonuclease L-PSP Sare_2440 46 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 159036075 Common - protein of unknown function DUF1470 Sare_0408 10 COG5516 COG5516, Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding General function prediction only 159037135 Nonpathogen - hypothetical protein Sare_1499 1 None None None 159036576 Nonpathogen - hypothetical protein Sare_0921 2 None None None 159040225 Nonpathogen - hypothetical protein Sare_4734 3 None None None 159039421 Common - aminopeptidase N Sare_3892 160 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 159036981 Common - GCN5-related N-acetyltransferase Sare_1342 13 None None None 159040229 Common - peptidase M23B Sare_4738 91 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 159039583 Common - transcriptional coactivator/pterin dehydratase Sare_4055 36 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 159036614 Common - Ricin B lectin Sare_0964 15 None None None 159037827 Common - polysaccharide deacetylase Sare_2229 96 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 159039092 Common - 2-oxoglutarate dehydrogenase E2 component Sare_3552 194 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 159039380 Common - degV family protein Sare_3849 47 COG1307 DegV, Uncharacterized protein conserved in bacteria Function unknown 159038137 Common - Lycopene beta and epsilon cyclase Sare_2557 11 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 159035812 Common - Adenylosuccinate synthase Sare_0139 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 159037925 Common - amine oxidase Sare_2329 49 COG1231 COG1231, Monoamine oxidase Amino acid transport and metabolism 159037297 Common - amylo-alpha-1,6-glucosidase Sare_1671 46 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 159038169 Common - protein of unknown function DUF181 Sare_2590 39 COG1944 COG1944, Uncharacterized conserved protein Function unknown 159037416 Common - ABC transporter related Sare_1792 249 COG0410 LivF, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 159036298 Common - Alcohol dehydrogenase zinc-binding domain protein Sare_0637 174 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 159036381 Common - Na+/solute symporter Sare_0724 125 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 159036126 Common - major facilitator superfamily MFS_1 Sare_0459 68 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 159036468 Nonpathogen - hypothetical protein Sare_0811 1 None None None 159037703 Common - aminotransferase class-III Sare_2100 235 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 159038709 Common - ferredoxin Sare_3163 13 COG1141 Fer, Ferredoxin Energy production and conversion 159036225 Nonpathogen - sterol-binding domain protein Sare_0558 3 COG3255 COG3255, Putative sterol carrier protein Lipid metabolism 159039093 Common - prolyl-tRNA synthetase Sare_3553 235 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159038388 Common - Enoyl-CoA hydratase/isomerase Sare_2815 179 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 159037631 Common - Activator of Hsp90 ATPase 1 family protein Sare_2023 11 COG3832 COG3832, Uncharacterized conserved protein Function unknown 159037459 Nonpathogen - Clp domain protein Sare_1835 1 None None None 159039088 Common - glycine cleavage system T protein Sare_3548 178 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 159035730 Common - sortase family protein Sare_0056 32 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 159036277 Nonpathogen - hypothetical protein Sare_0611 1 None None None 159040315 Nonpathogen - hypothetical protein Sare_4827 3 None None None 159040124 Common - hypothetical protein Sare_4628 8 COG4189 COG4189, Predicted transcriptional regulator Transcription 159040541 Common - diguanylate cyclase/phosphodiesterase Sare_5060 178 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 159040567 Common - methylated-DNA--protein-cysteine methyltransferase Sare_5087 192 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 159040130 Common - DEAD/DEAH box helicase domain protein Sare_4634 224 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 159038501 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sare_2937 157 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159039518 Common - LAO/AO transport system ATPase Sare_3990 100 COG1703 ArgK, Putative periplasmic protein kinase ArgK and related GTPases of G3E family Amino acid transport and metabolism 159037117 Common - Redoxin domain protein Sare_1481 34 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 159037319 Common - histidine kinase Sare_1694 208 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159037725 Common - cysteine desulfurase, SufS subfamily Sare_2122 237 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 159037541 Common - segregation and condensation protein B Sare_1918 152 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 159036033 Common - Cysteine synthase Sare_0366 220 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 159039303 Nonpathogen - hypothetical protein Sare_3772 1 None None None 159040385 Common - ABC transporter related Sare_4898 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159037531 Common - virulence factor MVIN family protein Sare_1908 5 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 159036200 Common - protein of unknown function DUF156 Sare_0533 108 COG1937 COG1937, Uncharacterized protein conserved in bacteria Function unknown 159037847 Common - ATP-dependent protease La Sare_2249 207 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 159037724 Common - protein of unknown function DUF323 Sare_2121 106 COG1262 COG1262, Uncharacterized conserved protein Function unknown 159035919 Nonpathogen - hypothetical protein Sare_0249 1 None None None 159036653 Common - protein of unknown function DUF437 Sare_1004 27 COG4405 COG4405, Uncharacterized protein conserved in bacteria Function unknown 159036900 Common - AHBA synthesis associated protein Sare_1257 57 COG0546 Gph, Predicted phosphatases General function prediction only 159037574 Common - Radical SAM domain protein Sare_1951 19 COG0641 AslB, Arylsulfatase regulator (Fe-S oxidoreductase) General function prediction only 159038847 Common - cysteine desulfurase, SufS subfamily Sare_3306 238 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 159040181 Common - 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Sare_4690 171 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 159038258 Common - Beta-ketoacyl synthase Sare_2683 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159037368 Common - aldehyde dehydrogenase Sare_1743 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 159036722 Common - glycoside hydrolase 15-related Sare_1076 66 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 159036718 Common - dTDP-4-dehydrorhamnose reductase Sare_1071 23 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 159039153 Nonpathogen - hypothetical protein Sare_3617 1 None None None 159036426 Common - transcriptional repressor, CopY family Sare_0769 13 COG3682 COG3682, Predicted transcriptional regulator Transcription 159038897 Common - Lytic transglycosylase catalytic Sare_3357 21 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 159036938 Nonpathogen - hypothetical protein Sare_1297 1 None None None 159039894 Common - parallel beta-helix repeat Sare_4375 18 None None None 159036883 Nonpathogen - hypothetical protein Sare_1240 1 None None None 159036700 Common - All-trans-retinol 13,14-reductase Sare_1053 79 COG1233 COG1233, Phytoene dehydrogenase and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159038197 Common - hypothetical protein Sare_2619 4 None None None 159036598 Nonpathogen - hypothetical protein Sare_0945 1 None None None 159035774 Common - beta-lactamase domain protein Sare_0101 59 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 159038731 Common - cellulose-binding family II Sare_3186 26 COG3469 COG3469, Chitinase Carbohydrate transport and metabolism 159040016 Common - NLP/P60 protein Sare_4506 111 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 159038559 Common - hypothetical protein Sare_2997 6 None None None 159039098 Common - domain of unknown function DUF1731 Sare_3558 105 COG1090 COG1090, Predicted nucleoside-diphosphate sugar epimerase General function prediction only 159038876 Common - hypothetical protein Sare_3335 6 None None None 159035716 Common - protein of unknown function DUF397 Sare_0042 6 None None None 159036596 Common - hypothetical protein Sare_0943 11 None None None 159039389 Common - ribosomal protein L27 Sare_3859 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 159038689 Common - Oxidoreductase FAD-binding domain protein Sare_3143 120 COG1017 Hmp, Hemoglobin-like flavoprotein Energy production and conversion 159037529 Common - hypothetical protein Sare_1906 16 None None None 159039503 Common - von Willebrand factor type A Sare_3975 15 None None None 159038421 Nonpathogen - hypothetical protein Sare_2848 1 None None None 159036206 Common - hypothetical protein Sare_0539 37 COG3483 TDO2, Tryptophan 2,3-dioxygenase (vermilion) Amino acid transport and metabolism 159037491 Common - riboflavin synthase, alpha subunit Sare_1868 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 159036148 Common - Nucleotidyl transferase Sare_0481 197 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 159037817 Common - Oxidoreductase FAD-binding domain protein Sare_2219 115 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 159039995 Nonpathogen - hypothetical protein Sare_4485 1 None None None 159037894 Common - hypothetical protein Sare_2298 10 None None None 159036239 Common - phosphoribosylglycinamide synthetase Sare_0573 38 COG0439 AccC, Biotin carboxylase Lipid metabolism 159036785 Common - Class I peptide chain release factor Sare_1139 13 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 159037133 Common - nuclease SbcCD, D subunit Sare_1497 97 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 159037768 Common - Activator of Hsp90 ATPase 1 family protein Sare_2166 11 COG3832 COG3832, Uncharacterized conserved protein Function unknown 159039395 Common - phospholipid/glycerol acyltransferase Sare_3865 146 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 159036244 Common - SAICAR synthetase Sare_0578 67 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 159036769 Common - acetolactate synthase, large subunit, biosynthetic type Sare_1123 222 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 159036925 Nonpathogen - hypothetical protein Sare_1283 1 None None None 159037189 Common - histidine kinase Sare_1555 189 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 159037356 Common - amino acid permease-associated region Sare_1731 122 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 159040114 Common - aminoglycoside phosphotransferase Sare_4618 64 COG3001 COG3001, Uncharacterized protein conserved in bacteria Function unknown 159038188 Nonpathogen - hypothetical protein Sare_2610 1 None None None 159038869 Common - hypothetical protein Sare_3328 140 COG1660 COG1660, Predicted P-loop-containing kinase General function prediction only 159038233 Common - Serine-type D-Ala-D-Ala carboxypeptidase Sare_2658 142 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 159038513 Common - Pyridoxal-dependent decarboxylase Sare_2949 115 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 159038833 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Sare_3292 68 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 159038586 Nonpathogen - prevent-host-death family protein Sare_3026 1 COG2161 StbD, Antitoxin of toxin-antitoxin stability system Cell division and chromosome partitioning 159040025 Common - cytochrome c assembly protein Sare_4515 80 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 159037166 Common - UspA domain protein Sare_1532 31 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 159036664 Nonpathogen - hypothetical protein Sare_1015 1 None None None 159037788 Common - peptidase U62 modulator of DNA gyrase Sare_2188 166 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 159039327 Common - MMPL domain protein Sare_3796 36 COG2409 COG2409, Predicted drug exporters of the RND superfamily General function prediction only 159039737 Common - phosphatidylserine decarboxylase related protein Sare_4218 91 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 159039521 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_3993 94 COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins Amino acid transport and metabolism / General function prediction only 159040322 Nonpathogen - hypothetical protein Sare_4834 1 None None None 159040499 Common - SSS sodium solute transporter superfamily Sare_5018 125 COG4147 DhlC, Predicted symporter General function prediction only 159039782 Common - protein of unknown function ATP binding Sare_4263 32 COG2229 COG2229, Predicted GTPase General function prediction only 159036258 Common - xenobiotic compound monooxygenase, DszA family, A subunit Sare_0592 62 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 159036080 Common - DNA binding domain, excisionase family Sare_0413 20 None None None 159038702 Common - Beta-ketoacyl synthase Sare_3156 210 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159039235 Nonpathogen - Peptidoglycan-binding domain 1 protein Sare_3704 3 COG2989 COG2989, Uncharacterized protein conserved in bacteria Function unknown 159037720 Common - UDP-glucose 6-dehydrogenase Sare_2117 206 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 159040188 Common - UbiA prenyltransferase Sare_4697 6 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 159036629 Nonpathogen - HesB/YadR/YfhF-family protein Sare_0979 4 COG0316 IscA, Uncharacterized conserved protein Function unknown 159039952 Common - peptidase S8 and S53 subtilisin kexin sedolisin Sare_4440 113 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 159039190 Common - polymorphic outer membrane protein Sare_3654 23 None None None 159035846 Common - Enoyl-CoA hydratase/isomerase Sare_0173 186 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 159038704 Common - tryptophan halogenase Sare_3158 56 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 159037180 Nonpathogen - hypothetical protein Sare_1546 1 None None None 159039076 Common - iron-sulfur cluster assembly accessory protein Sare_3536 163 COG0316 IscA, Uncharacterized conserved protein Function unknown 159039711 Nonpathogen - hypothetical protein Sare_4187 1 None None None 159035939 Common - helicase, RecD/TraA family Sare_0269 143 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 159035685 Nonpathogen - hypothetical protein Sare_0011 1 None None None 159037421 Common - 3-hydroxybutyrate dehydrogenase Sare_1797 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159035737 Common - hypothetical protein Sare_0063 10 None None None 159039063 Common - hypothetical protein Sare_3523 32 COG3652 COG3652, Predicted outer membrane protein Function unknown 159035698 Common - DSBA oxidoreductase Sare_0024 80 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 159038443 Common - Acyl-CoA dehydrogenase type 2 domain Sare_2879 45 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159038456 Common - beta-lactamase domain protein Sare_2892 177 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 159036885 Common - oxidoreductase domain protein Sare_1242 163 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 159037791 Common - ATPase AAA-2 domain protein Sare_2192 220 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 159036836 Common - signal recognition particle protein Sare_1190 246 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 159035930 Nonpathogen - hypothetical protein Sare_0260 1 None None None 159037241 Common - polymorphic outer membrane protein Sare_1610 11 None None None 159038478 Common - two component transcriptional regulator, winged helix family Sare_2914 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159037301 Common - DNA topoisomerase (ATP-hydrolyzing) Sare_1675 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 159039199 Nonpathogen - hypothetical protein Sare_3664 2 None None None 159040527 Common - molybdenum cofactor biosynthesis protein A Sare_5046 195 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 159035693 Common - tRNA synthetase valyl/leucyl anticodon-binding Sare_0019 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159036450 Common - Caffeoyl-CoA O-methyltransferase Sare_0793 103 COG4122 COG4122, Predicted O-methyltransferase General function prediction only 159038339 Common - two component transcriptional regulator, winged helix family Sare_2766 215 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159038273 Nonpathogen - CrcB protein Sare_2698 3 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 159037808 Common - hypothetical protein Sare_2209 9 None None None 159038305 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Sare_2732 116 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 159040020 Common - transcriptional regulator, AsnC family Sare_4510 161 COG1522 Lrp, Transcriptional regulators Transcription 159035952 Common - TrkA-N domain protein Sare_0283 45 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 159036345 Nonpathogen - hypothetical protein Sare_0686 1 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 159040152 Common - peptidase S8 and S53 subtilisin kexin sedolisin Sare_4661 104 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 159040578 Common - thioredoxin Sare_5098 234 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 159039909 Common - Protein-L-isoaspartate(D-aspartate) O-methyltransferase Sare_4394 145 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 159036797 Common - histone family protein DNA-binding protein Sare_1151 203 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 159040145 Common - GCN5-related N-acetyltransferase Sare_4651 114 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 159038396 Common - transcriptional regulator, TetR family Sare_2823 40 COG1309 AcrR, Transcriptional regulator Transcription 159036862 Nonpathogen - hypothetical protein Sare_1217 1 None None None 159038227 Nonpathogen - hypothetical protein Sare_2652 3 None None None 159035975 Common - phenylacetic acid degradation protein paaN Sare_0307 177 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 159037088 Common - TrkA-N domain protein Sare_1451 150 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 159035779 Nonpathogen - hypothetical protein Sare_0106 1 None None None 159036539 Common - NUDIX hydrolase Sare_0883 13 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 159038832 Common - protein of unknown function RIO1 Sare_3291 66 COG1718 RIO1, Serine/threonine protein kinase involved in cell cycle control Signal transduction mechanisms / Cell division and chromosome partitioning 159037839 Nonpathogen - hypothetical protein Sare_2241 1 None None None 159039287 Nonpathogen - hypothetical protein Sare_3756 1 None None None 159039344 Nonpathogen - hypothetical protein Sare_3813 1 None None None 159035754 Common - GCN5-related N-acetyltransferase Sare_0081 15 COG0456 RimI, Acetyltransferases General function prediction only 159038544 Nonpathogen - hypothetical protein Sare_2981 1 None None None 159039977 Common - ubiquinone/menaquinone biosynthesis methyltransferase Sare_4465 227 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159038569 Nonpathogen - hypothetical protein Sare_3007 3 COG3408 GDB1, Glycogen debranching enzyme Carbohydrate transport and metabolism 159036960 Common - hypothetical protein Sare_1321 12 None None None 159039485 Common - hypothetical protein Sare_3957 23 None None None 159036821 Common - ribosomal protein L32 Sare_1175 72 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 159037626 Nonpathogen - hypothetical protein Sare_2015 1 None None None 159039360 Nonpathogen - hypothetical protein Sare_3829 1 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 159039949 Common - alpha/beta hydrolase fold Sare_4437 141 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159039493 Nonpathogen - hypothetical protein Sare_3965 1 None None None 159037629 Common - hypothetical protein Sare_2020 7 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 159039379 Common - competence protein ComEA helix-hairpin-helix repeat protein Sare_3848 86 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 159036680 Nonpathogen - hypothetical protein Sare_1033 1 None None None 159039578 Common - Carbohydrate binding family 6 Sare_4050 40 COG2273 SKN1, Beta-glucanase/Beta-glucan synthetase Carbohydrate transport and metabolism 159036214 Nonpathogen - hypothetical protein Sare_0547 1 None None None 159035980 Nonpathogen - hypothetical protein Sare_0312 1 None None None 159039815 Common - ribosomal protein L15 Sare_4296 216 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 159036755 Common - DNA ligase, NAD-dependent Sare_1109 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 159039776 Nonpathogen - hypothetical protein Sare_4257 1 None None None 159036113 Nonpathogen - hypothetical protein Sare_0446 1 None None None 159040390 Common - hypothetical protein Sare_4903 5 None None None 159037233 Common - histidine kinase Sare_1602 66 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 159039442 Common - globin Sare_3913 68 COG2346 COG2346, Truncated hemoglobins General function prediction only 159038860 Common - glucose-6-phosphate 1-dehydrogenase Sare_3319 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 159036134 Common - glutathione S-transferase-like protein Sare_0467 79 COG0435 ECM4, Predicted glutathione S-transferase Posttranslational modification, protein turnover, chaperones 159039936 Common - type II secretion system protein E Sare_4421 148 COG4962 CpaF, Flp pilus assembly protein, ATPase CpaF Intracellular trafficking and secretion 159037213 Common - putative plasmid replication initiator protein Sare_1580 4 None None None 159040491 Common - hypothetical protein Sare_5010 7 None None None 159037274 Common - transcriptional regulator, Crp/Fnr family Sare_1644 118 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 159038566 Common - Acetyl xylan esterase Sare_3004 24 COG3458 COG3458, Acetyl esterase (deacetylase) Secondary metabolites biosynthesis, transport, and catabolism 159036829 Common - protein of unknown function DUF664 Sare_1183 11 COG2318 DinB, Uncharacterized protein conserved in bacteria Function unknown 159037556 Common - hypothetical protein Sare_1933 4 None None None 159040532 Nonpathogen - hypothetical protein Sare_5051 1 COG5178 PRP8, U5 snRNP spliceosome subunit RNA processing and modification 159037503 Common - phenylalanyl-tRNA synthetase, beta subunit Sare_1880 213 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 159035676 Common - DNA polymerase III, beta subunit Sare_0002 210 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 159040485 Common - glycosyl transferase group 1 Sare_5004 48 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159036473 Common - Rhomboid family protein Sare_0816 37 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 159039447 Common - Alpha,alpha-trehalose-phosphate synthase (UDP-forming) Sare_3918 96 COG0380 OtsA, Trehalose-6-phosphate synthase Carbohydrate transport and metabolism 159037999 Common - transport system permease protein Sare_2403 109 COG4606 CeuB, ABC-type enterochelin transport system, permease component Inorganic ion transport and metabolism 159038246 Common - hypothetical protein Sare_2671 9 None None None 159039436 Common - transcriptional regulator, AsnC family Sare_3907 148 COG1522 Lrp, Transcriptional regulators Transcription 159039825 Common - ribosomal protein S17 Sare_4306 230 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 159037078 Common - Inositol-phosphate phosphatase Sare_1441 192 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 159039081 Common - Tetratricopeptide TPR_2 repeat protein Sare_3541 17 COG0457 NrfG, FOG: TPR repeat General function prediction only 159039024 Nonpathogen - hypothetical protein Sare_3484 1 None None None 159037713 Common - DNA alkylation repair enzyme Sare_2110 30 COG4912 COG4912, Predicted DNA alkylation repair enzyme DNA replication, recombination, and repair 159037173 Common - regulator of chromosome condensation RCC1 Sare_1539 43 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 159038390 Common - acyl-CoA dehydrogenase domain protein Sare_2817 75 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159037904 Common - ATPase AAA-2 domain protein Sare_2308 215 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 159038733 Common - transcriptional regulator, TetR family Sare_3188 28 COG1309 AcrR, Transcriptional regulator Transcription 159038542 Common - Resolvase helix-turn-helix domain protein Sare_2979 9 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 159036689 Nonpathogen - hypothetical protein Sare_1042 2 None None None 159038508 Nonpathogen - hypothetical protein Sare_2944 2 None None None 159038549 Common - ABC transporter related Sare_2987 247 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 159039146 Common - Transketolase domain protein Sare_3610 156 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 159039615 Common - signal transduction histidine kinase Sare_4087 71 COG3920 COG3920, Signal transduction histidine kinase Signal transduction mechanisms 159036283 Nonpathogen - hypothetical protein Sare_0619 1 None None None 159038071 Common - Xylose isomerase domain protein TIM barrel Sare_2490 55 COG1082 IolE, Sugar phosphate isomerases/epimerases Carbohydrate transport and metabolism 159035745 Common - hypothetical protein Sare_0072 14 None None None 159039337 Common - pyruvate, phosphate dikinase Sare_3806 233 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 159040560 Common - transcriptional regulator, PadR-like family Sare_5080 14 COG1695 COG1695, Predicted transcriptional regulators Transcription 159038840 Common - Enoyl-CoA hydratase/isomerase Sare_3299 179 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 159036365 Common - NADH-ubiquinone/plastoquinone oxidoreductase chain 3 Sare_0708 128 COG0838 NuoA, NADH:ubiquinone oxidoreductase subunit 3 (chain A) Energy production and conversion 159037362 Common - Conserved TM helix repeat-containing protein Sare_1737 22 None None None 159040133 Common - protein of unknown function DUF574 Sare_4637 12 COG3315 COG3315, O-Methyltransferase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 159037121 Common - methionine-R-sulfoxide reductase Sare_1485 194 COG0229 COG0229, Conserved domain frequently associated with peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 159036109 Common - hypothetical protein Sare_0442 27 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 159037655 Common - hypothetical protein Sare_2050 7 None None None 159040422 Common - NADPH-dependent FMN reductase Sare_4938 39 COG0431 COG0431, Predicted flavoprotein General function prediction only 159039270 Nonpathogen - hypothetical protein Sare_3739 1 None None None 159037204 Nonpathogen - hypothetical protein Sare_1570 1 None None None 159036188 Common - CDP-alcohol phosphatidyltransferase Sare_0521 32 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 159039561 Common - Homoserine dehydrogenase Sare_4033 215 COG0460 ThrA, Homoserine dehydrogenase Amino acid transport and metabolism 159040230 Nonpathogen - hypothetical protein Sare_4739 1 None None None 159035904 Common - purine nucleoside phosphorylase Sare_0231 97 COG0813 DeoD, Purine-nucleoside phosphorylase Nucleotide transport and metabolism 159040215 Common - binding-protein-dependent transport systems inner membrane component Sare_4724 71 COG1174 OpuBB, ABC-type proline/glycine betaine transport systems, permease component Amino acid transport and metabolism 159040237 Nonpathogen - hypothetical protein Sare_4746 1 None None None 159038092 Common - Integral membrane protein TerC Sare_2511 100 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 159039298 Common - portal protein Sare_3767 37 COG4695 COG4695, Phage-related protein Function unknown 159035708 Common - acyl-CoA dehydrogenase domain protein Sare_0034 164 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159038811 Nonpathogen - hypothetical protein Sare_3270 3 None None None 159040259 Common - Carbamoyl-phosphate synthase L chain ATP-binding Sare_4768 225 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 159036895 Nonpathogen - hypothetical protein Sare_1252 1 None None None 159035964 Common - short-chain dehydrogenase/reductase SDR Sare_0295 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159037610 Common - transposase IS3/IS911 family protein Sare_1991 6 None None None 159039463 Common - bifunctional deaminase-reductase domain protein Sare_3935 32 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 159035897 Nonpathogen - hypothetical protein Sare_0224 1 None None None 159040510 Nonpathogen - hypothetical protein Sare_5029 2 None None None 159037696 Common - AMP-dependent synthetase and ligase Sare_2093 207 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159037054 Common - transcriptional regulator, TetR family Sare_1416 105 COG1309 AcrR, Transcriptional regulator Transcription 159038525 Common - amino acid adenylation domain Sare_2961 221 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159036790 Nonpathogen - hypothetical protein Sare_1144 1 None None None 159035713 Nonpathogen - hypothetical protein Sare_0039 1 None None None 159040071 Nonpathogen - hypothetical protein Sare_4565 3 None None None 159037881 Common - putative transposase Sare_2285 50 COG3335 COG3335, Transposase and inactivated derivatives DNA replication, recombination, and repair 159040244 Common - cell divisionFtsK/SpoIIIE Sare_4753 187 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 159037151 Common - hypothetical protein Sare_1517 6 None None None 159040519 Common - extracellular ligand-binding receptor Sare_5038 85 COG0683 LivK, ABC-type branched-chain amino acid transport systems, periplasmic component Amino acid transport and metabolism 159039981 Common - phenylacetate-CoA oxygenase, PaaJ subunit Sare_4469 64 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 159037330 Common - succinate dehydrogenase and fumarate reductase iron-sulfur protein Sare_1705 31 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 159037335 Common - ThiJ/PfpI domain protein Sare_1710 98 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 159037863 Common - L-carnitine dehydratase/bile acid-inducible protein F Sare_2266 114 COG1804 CaiB, Predicted acyl-CoA transferases/carnitine dehydratase Energy production and conversion 159040261 Nonpathogen - hypothetical protein Sare_4770 1 None None None 159038713 Common - Activator of Hsp90 ATPase 1 family protein Sare_3168 18 COG3832 COG3832, Uncharacterized conserved protein Function unknown 159039705 Common - binding-protein-dependent transport systems inner membrane component Sare_4178 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 159036931 Common - Roadblock/LC7 family protein Sare_1290 11 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 159038078 Common - NADPH-dependent FMN reductase Sare_2497 65 COG0431 COG0431, Predicted flavoprotein General function prediction only 159037683 Common - condensation domain protein Sare_2079 57 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159036163 Common - (S)-2-hydroxy-acid oxidase Sare_0496 112 COG1304 LldD, L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases Energy production and conversion 159038968 Common - lipoprotein signal peptidase Sare_3428 32 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 159038099 Common - protein of unknown function DUF151 Sare_2518 77 COG1259 COG1259, Uncharacterized conserved protein Function unknown 159038814 Nonpathogen - hypothetical protein Sare_3273 2 None None None 159038906 Common - excinuclease ABC, B subunit Sare_3366 224 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 159036814 Common - Dak phosphatase Sare_1168 49 COG1461 COG1461, Predicted kinase related to dihydroxyacetone kinase General function prediction only 159037373 Common - glycosyl transferase group 1 Sare_1748 204 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159039986 Common - hypothetical protein Sare_4474 5 None None None 159035924 Common - recombination protein RecR Sare_0254 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 159038552 Nonpathogen - aminoglycoside phosphotransferase Sare_2990 8 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 159040333 Common - Phosphotransferase system, phosphocarrier protein HPr Sare_4845 7 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 159036845 Common - signal peptidase I Sare_1199 199 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 159036715 Common - Oxidoreductase FAD-binding domain protein Sare_1068 174 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 159037590 Nonpathogen - hypothetical protein Sare_1967 1 None None None 159038290 Common - transcriptional regulator, LacI family Sare_2715 124 COG1609 PurR, Transcriptional regulators Transcription 159038064 Common - phospholipid/glycerol acyltransferase Sare_2483 45 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 159039005 Nonpathogen - hypothetical protein Sare_3465 1 None None None 159037734 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sare_2131 50 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159039962 Common - proton-translocating NADH-quinone oxidoreductase, chain N Sare_4450 210 COG1007 NuoN, NADH:ubiquinone oxidoreductase subunit 2 (chain N) Energy production and conversion 159036583 Nonpathogen - hypothetical protein Sare_0930 1 None None None 159040475 Nonpathogen - hypothetical protein Sare_4994 2 None None None 159036003 Common - GCN5-related N-acetyltransferase Sare_0335 16 COG0456 RimI, Acetyltransferases General function prediction only 159037472 Common - carbamoyl-phosphate synthase, large subunit Sare_1849 232 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 159038595 Common - monooxygenase FAD-binding Sare_3035 74 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 159038895 Common - transcriptional regulator, MarR family Sare_3355 63 COG1846 MarR, Transcriptional regulators Transcription 159037582 Common - transcriptional regulator, XRE family Sare_1959 6 COG1813 COG1813, Predicted transcription factor, homolog of eukaryotic MBF1 Transcription 159036579 Common - protein of unknown function DUF397 Sare_0924 4 None None None 159038512 Common - amino acid adenylation domain Sare_2948 213 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159039065 Common - Rieske (2Fe-2S) domain protein Sare_3525 31 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 159040461 Nonpathogen - hypothetical protein Sare_4977 1 None None None 159036202 Nonpathogen - hypothetical protein Sare_0535 1 None None None 159040359 Common - protein of unknown function DUF1023 Sare_4871 10 None None None 159036186 Common - ABC-2 type transporter Sare_0519 101 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 159038475 Common - transcriptional regulator, TetR family Sare_2911 23 COG1309 AcrR, Transcriptional regulator Transcription 159038577 Common - hypothetical protein Sare_3015 3 None None None 159035688 Nonpathogen - hypothetical protein Sare_0014 1 None None None 159039022 Common - Threonine aldolase Sare_3482 78 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 159036287 Nonpathogen - hypothetical protein Sare_0625 1 None None None 159039631 Common - glycosyl transferase group 1 Sare_4103 203 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159036176 Common - hypothetical protein Sare_0509 19 None None None 159040008 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_4498 43 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 159035826 Common - arginyl-tRNA synthetase Sare_0153 247 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159036677 Common - hypothetical protein Sare_1029 12 COG0645 COG0645, Predicted kinase General function prediction only 159038085 Common - putative esterase Sare_2504 49 COG0627 COG0627, Predicted esterase General function prediction only 159038370 Common - hypothetical protein Sare_2797 19 None None None 159035960 Nonpathogen - hypothetical protein Sare_0291 3 None None None 159036462 Common - GtrA family protein Sare_0805 18 COG2246 COG2246, Predicted membrane protein Function unknown 159039638 Common - protein of unknown function UPF0182 Sare_4110 48 COG1615 COG1615, Uncharacterized conserved protein Function unknown 159040077 Nonpathogen - hypothetical protein Sare_4572 1 None None None 159036240 Common - Phthalate 4,5-dioxygenase Sare_0574 64 COG4638 HcaE, Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit Inorganic ion transport and metabolism / General function prediction only 159037888 Common - hypothetical protein Sare_2292 9 None None None 159036759 Common - glutamyl-tRNA(Gln) amidotransferase, B subunit Sare_1113 211 COG0064 GatB, Asp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit (PET112 homolog) Translation, ribosomal structure and biogenesis 159040255 Common - Wyosine base formation domain protein Sare_4764 11 None None None 159036376 Common - 4'-phosphopantetheinyl transferase Sare_0719 32 COG2977 EntD, Phosphopantetheinyl transferase component of siderophore synthetase Secondary metabolites biosynthesis, transport, and catabolism 159036249 Common - short-chain dehydrogenase/reductase SDR Sare_0583 209 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 159040302 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Sare_4814 81 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 159040162 Common - putative transcriptional regulator, TetR family Sare_4671 51 COG1309 AcrR, Transcriptional regulator Transcription 159040360 Nonpathogen - hypothetical protein Sare_4872 1 None None None 159039925 Nonpathogen - hypothetical protein Sare_4410 2 None None None 159037337 Common - major facilitator superfamily MFS_1 Sare_1712 33 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159040034 Common - protein serine/threonine phosphatase Sare_4524 99 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 159035724 Common - cell cycle protein Sare_0050 201 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 159038021 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Sare_2428 65 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 159038584 Nonpathogen - transposase IS4 family protein Sare_3023 4 None None None 159040209 Common - pantoate--beta-alanine ligase Sare_4718 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 159040311 Common - Ferritin Dps family protein Sare_4823 81 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 159038167 Common - Lantibiotic dehydratase domain protein Sare_2588 7 None None None 159036585 Nonpathogen - hypothetical protein Sare_0932 1 None None None 159036894 Common - N-acetyltransferase Sare_1251 39 COG2162 NhoA, Arylamine N-acetyltransferase Secondary metabolites biosynthesis, transport, and catabolism 159036634 Common - isochorismatase hydrolase Sare_0985 107 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 159035971 Nonpathogen - hypothetical protein Sare_0303 1 None None None 159038678 Common - sulfatase Sare_3132 74 COG3119 AslA, Arylsulfatase A and related enzymes Inorganic ion transport and metabolism 159039701 Common - Lactate/malate dehydrogenase Sare_4174 195 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 159037161 Common - hypothetical protein Sare_1527 22 None None None 159036580 Common - helix-turn-helix domain protein Sare_0926 6 None None None 159038432 Nonpathogen - hypothetical protein Sare_2866 2 None None None 159036157 Common - acyl-CoA dehydrogenase domain protein Sare_0490 130 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159037908 Common - transcriptional regulator, LysR family Sare_2312 157 COG0583 LysR, Transcriptional regulator Transcription 159039262 Nonpathogen - hypothetical protein Sare_3731 1 None None None 159037308 Common - Glutamine--scyllo-inositol transaminase Sare_1683 192 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 159035978 Common - cold-shock DNA-binding domain protein Sare_0310 182 COG1278 CspC, Cold shock proteins Transcription 159039601 Common - acetate kinase Sare_4073 162 COG0282 ackA, Acetate kinase Energy production and conversion 159040149 Common - RNA methyltransferase, TrmH family, group 3 Sare_4658 214 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 159039515 Common - Arginase/agmatinase/formiminoglutamase Sare_3987 35 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 159039651 Common - helix-turn-helix domain protein Sare_4123 6 None None None 159037131 Nonpathogen - protein of unknown function DUF430 Sare_1495 5 COG2380 COG2380, Uncharacterized protein conserved in bacteria Function unknown 159038364 Common - cobalt ABC transporter, inner membrane subunit CbiQ Sare_2791 33 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 159039592 Common - two component transcriptional regulator, winged helix family Sare_4064 213 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159040406 Common - hypothetical protein Sare_4920 27 None None None 159036703 Common - Phosphopantetheinyl transferase-like protein Sare_1056 26 COG2091 Sfp, Phosphopantetheinyl transferase Coenzyme metabolism 159038052 Common - transcriptional regulator, TetR family Sare_2470 10 COG1309 AcrR, Transcriptional regulator Transcription 159036485 Common - transcription-repair coupling factor Sare_0829 220 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 159040515 Nonpathogen - hypothetical protein Sare_5034 1 None None None 159036922 Common - putative large secreted protein Sare_1279 15 None None None 159039819 Common - ribosomal protein L6 Sare_4300 243 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 159037523 Common - hypothetical protein Sare_1900 2 COG3937 COG3937, Uncharacterized conserved protein Function unknown 159036416 Common - adenosine deaminase Sare_0759 101 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 159039863 Common - transcriptional regulator, GntR family Sare_4344 81 COG2188 PhnF, Transcriptional regulators Transcription 159039163 Common - hypothetical protein Sare_3627 17 None None None 159039228 Nonpathogen - hypothetical protein Sare_3697 1 None None None 159040198 Common - amino acid-binding ACT domain protein Sare_4707 23 COG2716 GcvR, Glycine cleavage system regulatory protein Amino acid transport and metabolism 159036622 Nonpathogen - hypothetical protein Sare_0972 1 None None None 159038614 Nonpathogen - phosphopantetheine-binding Sare_3057 4 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159036587 Nonpathogen - hypothetical protein Sare_0934 2 None None None 159039594 Common - hypothetical protein Sare_4066 60 COG3176 COG3176, Putative hemolysin General function prediction only 159037092 Nonpathogen - hypothetical protein Sare_1455 1 None None None 159039150 Nonpathogen - cyclase/dehydrase Sare_3614 1 COG5637 COG5637, Predicted integral membrane protein Function unknown 159039992 Common - hypothetical protein Sare_4482 34 COG3973 COG3973, Superfamily I DNA and RNA helicases General function prediction only 159035878 Common - NUDIX hydrolase Sare_0205 98 COG2816 NPY1, NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding DNA replication, recombination, and repair 159037311 Nonpathogen - hypothetical protein Sare_1686 1 None None None 159039732 Common - extracellular solute-binding protein family 5 Sare_4213 194 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 159036545 Common - hypothetical protein Sare_0890 15 COG3824 COG3824, Uncharacterized protein conserved in bacteria Function unknown 159036454 Nonpathogen - hypothetical protein Sare_0797 1 None None None 159037050 Common - hypothetical protein Sare_1412 16 COG4427 COG4427, Uncharacterized protein conserved in bacteria Function unknown 159036564 Common - GCN5-related N-acetyltransferase Sare_0909 71 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 159036150 Common - UDP-glucose/GDP-mannose dehydrogenase Sare_0483 206 COG0677 WecC, UDP-N-acetyl-D-mannosaminuronate dehydrogenase Cell envelope biogenesis, outer membrane 159036498 Common - Uracil-DNA glycosylase superfamily Sare_0842 86 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 159038128 Common - protein of unknown function UPF0027 Sare_2548 117 COG1690 RtcB, Uncharacterized conserved protein Function unknown 159038843 Common - hypothetical protein Sare_3302 5 COG1503 eRF1, Peptide chain release factor 1 (eRF1) Translation, ribosomal structure and biogenesis 159036707 Common - hypothetical protein Sare_1060 22 COG2030 MaoC, Acyl dehydratase Lipid metabolism 159038881 Common - ribosome small subunit-dependent GTPase A Sare_3340 160 COG1162 COG1162, Predicted GTPases General function prediction only 159036036 Common - putative two component transcriptional regulator, winged helix family Sare_0369 57 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159038775 Common - hypothetical protein Sare_3230 4 None None None 159039258 Common - hypothetical protein Sare_3727 2 None None None 159038465 Common - ribosomal protein L31 Sare_2901 138 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 159039251 Nonpathogen - hypothetical protein Sare_3720 1 None None None 159036744 Nonpathogen - hypothetical protein Sare_1098 1 None None None 159036266 Common - helix-turn-helix domain protein Sare_0600 6 None None None 159038427 Common - IstB domain protein ATP-binding protein Sare_2855 98 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 159039622 Common - Anti-sigma factor RshA Sare_4094 12 None None None 159035940 Common - Domain of unknown function DUF1905 Sare_0270 14 None None None 159036336 Nonpathogen - hypothetical protein Sare_0677 1 None None None 159039667 Common - Prephenate dehydrogenase Sare_4139 148 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 159035711 Common - hypothetical protein Sare_0037 20 None None None 159036144 Common - protein of unknown function DUF520 Sare_0477 107 COG1666 COG1666, Uncharacterized protein conserved in bacteria Function unknown 159037751 Common - protein of unknown function DUF201 Sare_2148 41 COG0439 AccC, Biotin carboxylase Lipid metabolism 159038780 Common - thiamine pyrophosphate protein central region Sare_3238 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 159039689 Nonpathogen - hypothetical protein Sare_4162 1 None None None 159038985 Nonpathogen - hypothetical protein Sare_3445 1 None None None 159037262 Common - chitin-binding domain 3 protein Sare_1632 25 COG3397 COG3397, Uncharacterized protein conserved in bacteria Function unknown 159040368 Nonpathogen - hypothetical protein Sare_4880 2 None None None 159036767 Common - dihydroxy-acid dehydratase Sare_1121 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 159038939 Common - hypothetical protein Sare_3399 3 None None None 159037891 Common - Cytochrome c oxidase subunit I type Sare_2295 168 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 159039219 Nonpathogen - hypothetical protein Sare_3688 1 None None None 159037564 Nonpathogen - hypothetical protein Sare_1941 1 None None None 159039558 Common - major facilitator superfamily MFS_1 Sare_4030 103 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159039471 Nonpathogen - hypothetical protein Sare_3943 1 None None None 159037018 Common - FG-GAP repeat protein Sare_1380 36 None None None 159038789 Nonpathogen - hypothetical protein Sare_3247 3 None None None 159040005 Nonpathogen - glycosyl transferase family 2 Sare_4495 1 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 159037140 Common - extracellular solute-binding protein family 1 Sare_1506 47 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 159038420 Nonpathogen - hypothetical protein Sare_2847 1 None None None 159039692 Common - ABC transporter related Sare_4165 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 159039434 Common - kynureninase Sare_3905 62 COG3844 COG3844, Kynureninase Amino acid transport and metabolism 159040140 Nonpathogen - hypothetical protein Sare_4645 2 None None None 159040350 Common - Abortive infection protein Sare_4862 28 COG1266 COG1266, Predicted metal-dependent membrane protease General function prediction only 159038447 Common - fumarate reductase/succinate dehydrogenase flavoprotein domain protein Sare_2883 32 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 159039980 Common - phenylacetate-CoA oxygenase/reductase, PaaK subunit Sare_4468 141 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 159040200 Common - ATPase AAA-2 domain protein Sare_4709 219 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 159038975 Common - alanine racemase domain protein Sare_3435 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 159039675 Common - peptidase U62 modulator of DNA gyrase Sare_4147 166 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 159039113 Nonpathogen - hypothetical protein Sare_3575 1 None None None 159038013 Common - protein serine/threonine phosphatase Sare_2419 132 COG0631 PTC1, Serine/threonine protein phosphatase Signal transduction mechanisms 159036429 Common - deoxyribose-phosphate aldolase Sare_0772 138 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 159036294 Common - Gluconolactonase Sare_0633 86 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 159039997 Nonpathogen - hypothetical protein Sare_4487 1 None None None 159037310 Common - glycosyl transferase group 1 Sare_1685 20 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159037829 Common - protein of unknown function DUF397 Sare_2231 6 None None None 159038001 Nonpathogen - hypothetical protein Sare_2406 1 None None None 159039366 Common - chaperone protein DnaJ Sare_3835 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 159037259 Common - bifunctional deaminase-reductase domain protein Sare_1629 45 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 159038966 Nonpathogen - hypothetical protein Sare_3426 2 None None None 159040179 Common - homogentisate 12-dioxygenase Sare_4688 29 COG3508 HmgA, Homogentisate 1,2-dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 159039832 Common - Ribosomal protein L25/L23 Sare_4313 106 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 159037341 Common - DEAD/DEAH box helicase domain protein Sare_1716 122 COG4581 COG4581, Superfamily II RNA helicase DNA replication, recombination, and repair 159037970 Common - DEAD/DEAH box helicase domain protein Sare_2374 86 COG4581 COG4581, Superfamily II RNA helicase DNA replication, recombination, and repair 159037660 Common - hypothetical protein Sare_2055 12 None None None 159036952 Nonpathogen - hypothetical protein Sare_1313 1 None None None 159036355 Nonpathogen - transcriptional regulator, XRE family Sare_0697 1 COG2944 COG2944, Predicted transcriptional regulator Transcription 159036526 Common - diguanylate cyclase/phosphodiesterase Sare_0870 169 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 159036974 Nonpathogen - hypothetical protein Sare_1335 1 None None None 159037005 Nonpathogen - hypothetical protein Sare_1366 1 None None None 159037545 Common - integrase family protein Sare_1922 100 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 159035900 Common - peptidase M23B Sare_0227 12 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 159039035 Common - putative alpha-1,2-mannosidase Sare_3495 30 COG3537 COG3537, Putative alpha-1,2-mannosidase Carbohydrate transport and metabolism 159040441 Common - pyridine nucleotide-disulphide oxidoreductase dimerisation region Sare_4957 239 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 159039213 Nonpathogen - hypothetical protein Sare_3682 1 None None None 159037235 Nonpathogen - hypothetical protein Sare_1604 1 None None None 159037820 Nonpathogen - hypothetical protein Sare_2222 1 None None None 159040347 Common - protein of unknown function DUF305 Sare_4859 29 COG3544 COG3544, Uncharacterized protein conserved in bacteria Function unknown 159039913 Nonpathogen - hypothetical protein Sare_4398 9 None None None 159040102 Common - transcriptional regulator, winged helix family Sare_4606 30 COG3903 COG3903, Predicted ATPase General function prediction only 159040157 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sare_4666 133 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159040248 Common - NUDIX hydrolase Sare_4757 93 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 159036612 Common - aldo/keto reductase Sare_0962 186 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 159038205 Common - binding-protein-dependent transport systems inner membrane component Sare_2628 15 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 159037042 Common - Diaminopimelate epimerase Sare_1404 183 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 159038740 Common - major facilitator superfamily MFS_1 Sare_3195 201 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159038130 Common - binding-protein-dependent transport systems inner membrane component Sare_2550 45 COG1175 UgpA, ABC-type sugar transport systems, permease components Carbohydrate transport and metabolism 159039358 Nonpathogen - acyltransferase 3 Sare_3827 5 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 159036604 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Sare_0952 162 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 159040551 Nonpathogen - hypothetical protein Sare_5070 2 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 159037474 Common - adenosylmethionine-8-amino-7-oxononanoate aminotransferase Sare_1851 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 159035830 Common - phosphoribosylformylglycinamidine synthase, purS Sare_0157 107 COG1828 PurS, Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component Nucleotide transport and metabolism 159039636 Nonpathogen - hypothetical protein Sare_4108 1 None None None 159036010 Nonpathogen - hypothetical protein Sare_0342 1 None None None 159038529 Nonpathogen - hypothetical protein Sare_2965 1 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 159038147 Common - regulator of chromosome condensation, RCC1 Sare_2567 36 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 159036988 Common - hypothetical protein Sare_1349 2 None None None 159036025 Common - amino acid adenylation domain Sare_0357 214 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159037959 Common - dTDP-glucose 4,6-dehydratase Sare_2363 228 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 159038403 Common - short-chain dehydrogenase/reductase SDR Sare_2830 216 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159040227 Nonpathogen - hypothetical protein Sare_4736 3 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 159039277 Common - transcriptional regulator, XRE family Sare_3746 14 COG1396 HipB, Predicted transcriptional regulators Transcription 159036574 Common - protein of unknown function DUF214 Sare_0919 94 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 159039908 Common - GCN5-related N-acetyltransferase Sare_4392 4 COG1247 COG1247, Sortase and related acyltransferases Cell envelope biogenesis, outer membrane 159040041 Nonpathogen - hypothetical protein Sare_4531 1 None None None 159038292 Nonpathogen - hypothetical protein Sare_2717 1 None None None 159038859 Common - phosphoglucose isomerase (PGI) Sare_3318 113 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 159039224 Nonpathogen - hypothetical protein Sare_3693 1 None None None 159039756 Common - ABC transporter related Sare_4237 249 COG1129 MglA, ABC-type sugar transport system, ATPase component Carbohydrate transport and metabolism 159040191 Common - protein of unknown function DUF147 Sare_4700 28 COG1623 COG1623, Predicted nucleic-acid-binding protein (contains the HHH domain) General function prediction only 159040223 Common - dihydropteroate synthase Sare_4732 213 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 159036393 Common - inositol monophosphatase Sare_0736 117 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 159039408 Common - Endopeptidase Clp Sare_3878 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 159040095 Common - cobalt transport protein Sare_4597 27 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 159040219 Nonpathogen - inner-membrane translocator Sare_4728 1 COG1172 AraH, Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components Carbohydrate transport and metabolism 159035909 Common - major facilitator superfamily MFS_1 Sare_0236 13 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159037643 Common - aldo/keto reductase Sare_2035 199 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 159038698 Common - Beta-ketoacyl synthase Sare_3152 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159038522 Common - fumarate lyase Sare_2958 236 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 159037918 Common - Cysteine--tRNA ligase Sare_2322 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 159038271 Common - phenylacetic acid degradation protein PaaD Sare_2696 38 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 159036649 Common - urocanate hydratase Sare_1000 97 COG2987 HutU, Urocanate hydratase Amino acid transport and metabolism 159038802 Common - transcriptional regulator, MarR family Sare_3261 16 COG1846 MarR, Transcriptional regulators Transcription 159036077 Common - efflux transporter, RND family, MFP subunit Sare_0410 49 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 159037384 Nonpathogen - protein of unknown function DUF1469 Sare_1759 3 None None None 159038460 Common - Alpha-amylase Sare_2896 50 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 159037860 Common - glycosyl transferase group 1 Sare_2263 126 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 159039110 Nonpathogen - hypothetical protein Sare_3572 1 None None None 159038890 Common - FAD linked oxidase domain protein Sare_3350 143 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 159038174 Common - Siderophore-interacting protein Sare_2595 46 COG2375 ViuB, Siderophore-interacting protein Inorganic ion transport and metabolism 159038416 Common - peptidase S8 and S53 subtilisin kexin sedolisin Sare_2843 107 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 159037376 Common - short-chain dehydrogenase/reductase SDR Sare_1751 222 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 159040482 Common - nucleotidyl transferase Sare_5001 115 COG1213 COG1213, Predicted sugar nucleotidyltransferases Cell envelope biogenesis, outer membrane 159038794 Common - von Willebrand factor type A Sare_3252 38 COG1240 ChlD, Mg-chelatase subunit ChlD Coenzyme metabolism 159039734 Common - putative signal transduction histidine kinase Sare_4215 17 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 159039658 Common - UvrD/REP helicase Sare_4130 227 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 159039238 Nonpathogen - hypothetical protein Sare_3707 1 None None None 159037741 Common - aminopeptidase N Sare_2138 148 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 159036017 Common - Lanthionine synthetase C family protein Sare_0349 17 COG4403 LcnDR2, Lantibiotic modifying enzyme Defense mechanisms 159037036 Nonpathogen - hypothetical protein Sare_1398 2 COG3889 COG3889, Predicted solute binding protein General function prediction only 159038342 Nonpathogen - anti-sigma-factor antagonist Sare_2769 1 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 159040285 Common - hypothetical protein Sare_4794 20 COG0003 ArsA, Predicted ATPase involved in chromosome partitioning Cell division and chromosome partitioning 159038601 Common - hypothetical protein Sare_3043 58 None None None 159040298 Common - transcription activator effector binding Sare_4810 37 COG4978 COG4978, Transcriptional regulator, effector-binding domain/component Transcription / Signal transduction mechanisms 159039101 Common - lipoic acid synthetase Sare_3561 190 COG0320 LipA, Lipoate synthase Coenzyme metabolism 159036448 Common - IMP dehydrogenase family protein Sare_0791 237 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 159038379 Common - 2-nitropropane dioxygenase NPD Sare_2806 102 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 159040585 Common - Cobyrinic acid ac-diamide synthase Sare_5105 200 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 159040274 Common - hypothetical protein Sare_4783 14 None None None 159037446 Common - shikimate-5-dehydrogenase Sare_1822 57 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 159036061 Common - protein of unknown function DUF1503 Sare_0394 9 None None None 159038914 Common - ABC transporter related Sare_3374 249 COG0411 LivG, ABC-type branched-chain amino acid transport systems, ATPase component Amino acid transport and metabolism 159040376 Common - major facilitator superfamily MFS_1 Sare_4889 55 None None None 159038575 Common - Male sterility domain Sare_3013 109 COG3320 COG3320, Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 159039074 Common - SirA family protein Sare_3534 5 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 159038282 Common - cobyrinic acid a,c-diamide synthase Sare_2707 136 COG1797 CobB, Cobyrinic acid a,c-diamide synthase Coenzyme metabolism 159038267 Common - Polyketide synthesis cyclase Sare_2692 4 None None None 159040326 Nonpathogen - protein of unknown function DUF571 Sare_4838 3 None None None 159039200 Nonpathogen - hypothetical protein Sare_3666 3 COG3371 COG3371, Predicted membrane protein Function unknown 159039397 Common - alkaline phosphatase Sare_3867 54 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 159038667 Common - major facilitator superfamily MFS_1 Sare_3121 181 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159036476 Common - fructose-1,6-bisphosphatase, class II Sare_0820 112 COG1494 GlpX, Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins Carbohydrate transport and metabolism 159037252 Common - glycine betaine/L-proline ABC transporter, ATPase subunit Sare_1622 249 COG1125 OpuBA, ABC-type proline/glycine betaine transport systems, ATPase components Amino acid transport and metabolism 159039840 Nonpathogen - hypothetical protein Sare_4321 1 None None None 159037102 Common - hypothetical protein Sare_1466 15 None None None 159036108 Common - hypothetical protein Sare_0441 6 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 159036334 Common - thioredoxin Sare_0675 232 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 159037810 Common - major facilitator superfamily MFS_1 Sare_2211 174 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159037667 Nonpathogen - hypothetical protein Sare_2062 1 None None None 159038093 Common - Na+/H+ antiporter NhaA Sare_2512 103 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 159037592 Common - IstB domain protein ATP-binding protein Sare_1969 98 COG1484 DnaC, DNA replication protein DNA replication, recombination, and repair 159039956 Common - membrane protein of unknown function Sare_4444 29 COG1950 COG1950, Predicted membrane protein Function unknown 159039695 Common - ABC transporter related Sare_4168 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159036993 Common - MiaB-like tRNA modifying enzyme YliG Sare_1354 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 159039458 Common - cobalamin biosynthesis protein CobD Sare_3929 151 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 159036407 Nonpathogen - hypothetical protein Sare_0750 1 None None None 159038216 Nonpathogen - hypothetical protein Sare_2639 1 None None None 159037326 Common - peptidase M14 carboxypeptidase A Sare_1701 30 COG4412 COG4412, Uncharacterized protein conserved in bacteria Function unknown 159039837 Common - translation elongation factor G Sare_4318 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 159036303 Common - transcriptional regulator, XRE family Sare_0643 17 COG1396 HipB, Predicted transcriptional regulators Transcription 159037555 Common - NUDIX hydrolase Sare_1932 34 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 159036967 Common - protein of unknown function DUF503 Sare_1328 11 COG1550 COG1550, Uncharacterized protein conserved in bacteria Function unknown 159039858 Common - hypothetical protein Sare_4339 15 COG2378 COG2378, Predicted transcriptional regulator Transcription 159037602 Common - transposase IS4 family protein Sare_1979 76 COG3293 COG3293, Transposase and inactivated derivatives DNA replication, recombination, and repair 159039784 Common - Roadblock/LC7 family protein Sare_4265 11 COG2018 COG2018, Uncharacterized distant relative of homeotic protein bithoraxoid General function prediction only 159036422 Nonpathogen - hypothetical protein Sare_0765 1 None None None 159037933 Common - DegT/DnrJ/EryC1/StrS aminotransferase Sare_2337 195 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 159039823 Common - ribosomal protein L24 Sare_4304 211 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 159036644 Common - non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family Sare_0995 237 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 159039746 Common - inosine-5'-monophosphate dehydrogenase Sare_4227 240 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 159038791 Common - Ferrochelatase Sare_3249 75 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 159038607 Nonpathogen - hypothetical protein Sare_3050 1 None None None 159037196 Common - transcriptional regulator, LacI family Sare_1562 38 COG1609 PurR, Transcriptional regulators Transcription 159036403 Common - transcriptional regulator, LacI family Sare_0746 126 COG1609 PurR, Transcriptional regulators Transcription 159038670 Common - phenazine biosynthesis protein PhzF family Sare_3124 117 COG0384 COG0384, Predicted epimerase, PhzC/PhzF homolog General function prediction only 159037708 Common - cytochrome P450 Sare_2105 70 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159039999 Common - hypothetical protein Sare_4489 4 None None None 159039128 Common - Methyltransferase type 12 Sare_3591 14 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 159036955 Common - beta-ketoadipyl CoA thiolase Sare_1316 167 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 159039467 Common - two component transcriptional regulator, LuxR family Sare_3939 31 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 159038353 Nonpathogen - hypothetical protein Sare_2780 2 None None None 159036433 Common - methylmalonyl-CoA mutase, large subunit Sare_0776 109 COG1884 Sbm, Methylmalonyl-CoA mutase, N-terminal domain/subunit Lipid metabolism 159038184 Nonpathogen - hypothetical protein Sare_2606 1 None None None 159038276 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Sare_2701 50 COG2221 DsrA, Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits Energy production and conversion 159039942 Nonpathogen - hypothetical protein Sare_4429 1 None None None 159036684 Common - transcriptional regulator, TetR family Sare_1037 4 COG1309 AcrR, Transcriptional regulator Transcription 159039332 Common - hypothetical protein Sare_3801 3 None None None 159039723 Common - cobalamin B12-binding domain protein Sare_4204 113 COG2185 Sbm, Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) Lipid metabolism 159037288 Common - binding-protein-dependent transport systems inner membrane component Sare_1662 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 159037430 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Sare_1806 178 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 159036066 Common - hypothetical protein Sare_0399 10 None None None 159038632 Common - hypothetical protein Sare_3080 6 None None None 159036367 Common - respiratory-chain NADH dehydrogenase subunit 1 Sare_0710 137 COG1005 NuoH, NADH:ubiquinone oxidoreductase subunit 1 (chain H) Energy production and conversion 159036332 Common - hypothetical protein Sare_0672 2 None None None 159039419 Common - hypothetical protein Sare_3890 39 COG4198 COG4198, Uncharacterized conserved protein Function unknown 159038057 Common - major facilitator superfamily MFS_1 Sare_2475 178 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159036994 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Sare_1355 203 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 159039617 Common - Tetratricopeptide TPR_2 repeat protein Sare_4089 7 COG0457 NrfG, FOG: TPR repeat General function prediction only 159037790 Nonpathogen - hypothetical protein Sare_2191 1 None None None 159037405 Common - hypothetical protein Sare_1780 16 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 159038929 Common - transcriptional regulator, XRE family Sare_3389 52 COG1476 COG1476, Predicted transcriptional regulators Transcription 159037358 Common - GCN5-related N-acetyltransferase Sare_1733 90 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 159037997 Common - ABC transporter related Sare_2401 249 COG4604 CeuD, ABC-type enterochelin transport system, ATPase component Inorganic ion transport and metabolism 159040112 Common - hypothetical protein Sare_4616 41 COG2210 COG2210, Uncharacterized conserved protein Function unknown 159039124 Common - 3-methyl-2-oxobutanoate hydroxymethyltransferase Sare_3586 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 159038062 Common - cytochrome d ubiquinol oxidase, subunit II Sare_2481 156 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 159038997 Common - NADH dehydrogenase (quinone) Sare_3457 207 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 159035766 Common - channel protein, hemolysin III family Sare_0093 119 COG1272 COG1272, Predicted membrane protein, hemolysin III homolog General function prediction only 159037388 Nonpathogen - hypothetical protein Sare_1763 1 None None None 159037034 Nonpathogen - hypothetical protein Sare_1396 1 None None None 159039237 Nonpathogen - hypothetical protein Sare_3706 1 None None None 159037000 Common - transcriptional regulator, XRE family Sare_1361 42 COG1396 HipB, Predicted transcriptional regulators Transcription 159036459 Common - carboxyl transferase Sare_0802 217 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 159036627 Common - pentapeptide repeat protein Sare_0977 78 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 159039325 Common - integrase family protein Sare_3794 185 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 159035989 Common - chaperonin Cpn10 Sare_0321 32 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 159039803 Common - tRNA pseudouridine synthase A Sare_4284 233 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 159038624 Nonpathogen - hypothetical protein Sare_3067 1 None None None 159039959 Common - protein of unknown function DUF839 Sare_4447 74 COG3211 PhoX, Predicted phosphatase General function prediction only 159036174 Nonpathogen - hypothetical protein Sare_0507 1 None None None 159040493 Common - ABC transporter related Sare_5012 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 159036015 Common - secreted protein Sare_0347 12 None None None 159037360 Common - hypothetical protein Sare_1735 7 COG3380 COG3380, Predicted NAD/FAD-dependent oxidoreductase General function prediction only 159040059 Common - cytochrome P450 Sare_4553 72 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159040139 Nonpathogen - hypothetical protein Sare_4644 3 None None None 159036927 Common - cytochrome P450 Sare_1286 77 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159035731 Common - protein of unknown function DUF881 Sare_0057 25 COG3879 COG3879, Uncharacterized protein conserved in bacteria Function unknown 159039759 Nonpathogen - hypothetical protein Sare_4240 2 None None None 159039393 Common - Radical SAM domain protein Sare_3863 65 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 159038590 Nonpathogen - hypothetical protein Sare_3030 1 None None None 159037164 Common - hypothetical protein Sare_1530 14 None None None 159039465 Common - putative signal transduction histidine kinase Sare_3937 5 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 159037187 Nonpathogen - hypothetical protein Sare_1553 5 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 159036021 Common - amino acid adenylation domain Sare_0353 220 COG1020 EntF, Non-ribosomal peptide synthetase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 159036724 Common - hypothetical protein Sare_1078 11 COG3934 COG3934, Endo-beta-mannanase Carbohydrate transport and metabolism 159039197 Common - Radical SAM domain protein Sare_3662 6 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 159035890 Nonpathogen - hypothetical protein Sare_0217 1 None None None 159038235 Common - putative transcriptional regulator, GntR family Sare_2660 146 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 159035839 Nonpathogen - hypothetical protein Sare_0166 1 None None None 159037793 Common - ABC-1 domain protein Sare_2194 183 COG0661 AarF, Predicted unusual protein kinase General function prediction only 159038515 Common - methylaspartate mutase subunit S Sare_2951 4 COG2185 Sbm, Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding) Lipid metabolism 159037945 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Sare_2349 160 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 159038084 Common - LGFP repeat protein Sare_2503 21 COG5479 COG5479, Uncharacterized protein potentially involved in peptidoglycan biosynthesis Cell envelope biogenesis, outer membrane 159038162 Common - protein of unknown function DUF181 Sare_2583 45 COG1944 COG1944, Uncharacterized conserved protein Function unknown 159039714 Common - transcriptional regulator, ArsR family Sare_4195 34 COG0640 ArsR, Predicted transcriptional regulators Transcription 159038933 Common - monooxygenase FAD-binding Sare_3393 20 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 159038956 Common - bifunctional HisA/TrpF protein Sare_3416 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 159035695 Common - ATPase, P-type (transporting), HAD superfamily, subfamily IC Sare_0021 230 COG0474 MgtA, Cation transport ATPase Inorganic ion transport and metabolism 159036208 Common - Methyltransferase type 12 Sare_0541 34 COG4106 Tam, Trans-aconitate methyltransferase General function prediction only 159038454 Common - transcriptional regulator, TetR family Sare_2890 65 COG1309 AcrR, Transcriptional regulator Transcription 159037841 Nonpathogen - anti-sigma-factor antagonist Sare_2243 1 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 159040022 Common - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Sare_4512 150 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 159037271 Common - hypothetical protein Sare_1641 4 None None None 159036323 Common - protein of unknown function DUF1003 Sare_0663 34 COG4420 COG4420, Predicted membrane protein Function unknown 159036414 Common - hypothetical protein Sare_0757 2 None None None 159040027 Common - cytochrome c biogenesis protein transmembrane region Sare_4517 39 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 159036887 Nonpathogen - hypothetical protein Sare_1244 1 None None None 159039880 Common - glycosyl transferase family 2 Sare_4361 7 COG1215 COG1215, Glycosyltransferases, probably involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 159038303 Common - ferric uptake regulator, Fur family Sare_2730 188 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 159038638 Common - hypothetical protein Sare_3087 48 None None None 159035932 Common - drug resistance transporter, EmrB/QacA subfamily Sare_0262 175 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159037243 Nonpathogen - Peptidoglycan-binding domain 1 protein Sare_1612 2 None None None 159037332 Common - succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family Sare_1707 30 None None None 159036991 Common - small multidrug resistance protein Sare_1352 146 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 159036005 Common - putative two component transcriptional regulator, winged helix family Sare_0337 205 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159035848 Common - Activator of Hsp90 ATPase 1 family protein Sare_0175 9 COG3832 COG3832, Uncharacterized conserved protein Function unknown 159040122 Common - Haloacid dehalogenase domain protein hydrolase Sare_4626 8 COG0546 Gph, Predicted phosphatases General function prediction only 159038892 Common - methyltransferase small Sare_3352 23 COG3897 COG3897, Predicted methyltransferase General function prediction only 159040576 Nonpathogen - hypothetical protein Sare_5096 1 None None None 159037428 Common - adenine phosphoribosyltransferase Sare_1804 166 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 159039677 Common - hypothetical protein Sare_4149 10 None None None 159039892 Nonpathogen - hypothetical protein Sare_4373 7 None None None 159036226 Common - Wyosine base formation domain protein Sare_0559 11 None None None 159036937 Nonpathogen - hypothetical protein Sare_1296 1 None None None 159039505 Common - protein of unknown function ATP binding Sare_3977 29 COG2229 COG2229, Predicted GTPase General function prediction only 159036071 Common - two component transcriptional regulator, winged helix family Sare_0404 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 159036515 Common - Glutathione synthase Sare_0859 66 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 159039186 Nonpathogen - hypothetical protein Sare_3650 1 None None None 159036128 Common - NADH-quinone oxidoreductase, B subunit Sare_0461 192 COG0377 NuoB, NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases Energy production and conversion 159036466 Common - undecaprenyl diphosphate synthase Sare_0809 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 159037727 Common - hypothetical protein Sare_2124 20 COG5552 COG5552, Uncharacterized conserved protein Function unknown 159037781 Common - Cystathionine gamma-synthase Sare_2181 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 159037457 Common - hypothetical protein Sare_1833 6 None None None 159037748 Common - extracellular solute-binding protein family 5 Sare_2145 11 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 159036305 Common - thiamine pyrophosphate protein domain protein TPP-binding Sare_0645 118 COG1013 PorB, Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit Energy production and conversion 159037577 Common - putative O-methyltransferase Sare_1954 14 None None None 159038256 Common - AMP-dependent synthetase and ligase Sare_2681 156 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159036914 Common - Methyltransferase type 11 Sare_1271 215 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159039845 Common - ribosomal protein L7/L12 Sare_4326 213 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 159038996 Nonpathogen - NADH-ubiquinone oxidoreductase chain 4L Sare_3456 1 COG1006 MnhC, Multisubunit Na+/H+ antiporter, MnhC subunit Inorganic ion transport and metabolism 159037069 Common - protein of unknown function DUF397 Sare_1432 6 None None None 159036119 Common - transcriptional regulator, TetR family Sare_0452 66 COG1309 AcrR, Transcriptional regulator Transcription 159039642 Common - protein of unknown function DUF45 Sare_4114 112 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 159037158 Nonpathogen - putative cyclase-dehydratase Sare_1524 2 None None None 159038131 Common - ABC transporter related Sare_2551 249 COG3839 MalK, ABC-type sugar transport systems, ATPase components Carbohydrate transport and metabolism 159037761 Common - amino acid permease-associated region Sare_2158 63 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 159037778 Common - hypothetical protein Sare_2178 7 None None None 159035910 Common - Methyltransferase type 11 Sare_0237 167 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159039439 Common - HNH endonuclease Sare_3910 95 COG1403 McrA, Restriction endonuclease Defense mechanisms 159037064 Common - D-tyrosyl-tRNA(Tyr) deacylase Sare_1427 138 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 159037119 Common - chitin-binding domain 3 protein Sare_1483 26 COG3397 COG3397, Uncharacterized protein conserved in bacteria Function unknown 159035850 Common - Sterol 3-beta-glucosyltransferase Sare_0177 36 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 159040066 Common - cytochrome P450 Sare_4560 85 COG2124 CypX, Cytochrome P450 Secondary metabolites biosynthesis, transport, and catabolism 159038494 Nonpathogen - hypothetical protein Sare_2930 3 None None None 159036111 Common - H(+)-transporting two-sector ATPase Sare_0444 83 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 159035973 Common - threonine synthase Sare_0305 195 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 159036057 Common - Beta-glucosidase Sare_0390 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 159039719 Common - hypothetical protein Sare_4200 4 COG5283 COG5283, Phage-related tail protein Function unknown 159036252 Common - HAD-superfamily hydrolase, subfamily IIB Sare_0586 14 COG0561 Cof, Predicted hydrolases of the HAD superfamily General function prediction only 159040011 Common - periplasmic binding protein Sare_4501 163 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 159038039 Common - major intrinsic protein Sare_2455 96 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 159038685 Common - nitrate reductase, beta subunit Sare_3139 150 COG1140 NarY, Nitrate reductase beta subunit Energy production and conversion 159039805 Common - DNA-directed RNA polymerase, alpha subunit Sare_4286 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 159038527 Common - major facilitator superfamily MFS_1 Sare_2963 197 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159039619 Common - transcriptional regulator, TetR family Sare_4091 113 COG1309 AcrR, Transcriptional regulator Transcription 159038845 Common - protein of unknown function DUF59 Sare_3304 139 COG2151 PaaD, Predicted metal-sulfur cluster biosynthetic enzyme General function prediction only 159038244 Common - Transketolase central region Sare_2669 154 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 159038032 Common - ABC transporter related Sare_2447 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 159039793 Common - thiamine biosynthesis protein ThiC Sare_4274 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 159040520 Common - amidinotransferase Sare_5039 29 COG1834 COG1834, N-Dimethylarginine dimethylaminohydrolase Amino acid transport and metabolism 159037845 Common - nitroreductase Sare_2247 17 COG0778 NfnB, Nitroreductase Energy production and conversion 159039906 Nonpathogen - hypothetical protein Sare_4390 1 None None None 159037638 Common - 3-Oxoacyl-(acyl-carrier-protein (ACP)) synthase III domain protein Sare_2030 10 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 159038645 Common - Recombinase Sare_3094 31 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 159038867 Common - protein of unknown function DUF199 Sare_3326 43 COG1481 COG1481, Uncharacterized protein conserved in bacteria Function unknown 159038414 Common - Propanoyl-CoA C-acyltransferase Sare_2841 90 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 159037605 Nonpathogen - hypothetical protein Sare_1985 2 None None None 159039171 Common - DSBA oxidoreductase Sare_3635 66 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 159037657 Nonpathogen - hypothetical protein Sare_2052 1 None None None 159035810 Common - ATPase involved in chromosome partitioning-like protein Sare_0137 14 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 159035882 Common - hypothetical protein Sare_0209 7 None None None 159038437 Nonpathogen - hypothetical protein Sare_2872 1 None None None 159038386 Common - short-chain dehydrogenase/reductase SDR Sare_2813 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159036807 Nonpathogen - hypothetical protein Sare_1161 1 None None None 159038520 Common - cystathionine beta-synthase Sare_2956 219 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 159037506 Common - acetylglutamate kinase Sare_1883 218 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 159038878 Common - excinuclease ABC, C subunit Sare_3337 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 159039669 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Sare_4141 150 COG1146 COG1146, Ferredoxin Energy production and conversion 159040338 Common - PfkB domain protein Sare_4850 90 COG1105 FruK, Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) Carbohydrate transport and metabolism 159035875 Common - molybdopterin dehydrogenase FAD-binding Sare_0202 94 COG1319 CoxM, Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs Energy production and conversion 159037493 Common - 3,4-dihydroxy-2-butanone 4-phosphate synthase Sare_1870 232 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 159037220 Nonpathogen - hypothetical protein Sare_1589 1 None None None 159039568 Common - transcriptional regulator, HxlR family Sare_4040 134 COG1733 COG1733, Predicted transcriptional regulators Transcription 159036853 Common - Inosine/uridine-preferring nucleoside hydrolase Sare_1207 60 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 159040097 Common - parallel beta-helix repeat Sare_4599 10 None None None 159038757 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Sare_3212 223 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 159040014 Nonpathogen - hypothetical protein Sare_4504 1 None None None 159035954 Common - hypothetical protein Sare_0285 14 None None None 159037371 Common - hydrolase, HAD-superfamily, subfamily IIIA Sare_1746 123 COG0241 HisB, Histidinol phosphatase and related phosphatases Amino acid transport and metabolism 159038195 Common - ABC-3 protein Sare_2617 189 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 159038816 Common - peptidase U62 modulator of DNA gyrase Sare_3275 149 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 159039132 Common - protein of unknown function DUF164 Sare_3596 40 COG1579 COG1579, Zn-ribbon protein, possibly nucleic acid-binding General function prediction only 159039873 Common - peptidylprolyl isomerase FKBP-type Sare_4354 132 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 159035772 Common - protein of unknown function DUF397 Sare_0099 6 None None None 159038597 Common - peptidase M7 snapalysin Sare_3037 27 COG5640 COG5640, Secreted trypsin-like serine protease Posttranslational modification, protein turnover, chaperones 159039461 Common - hypothetical protein Sare_3932 18 COG2267 PldB, Lysophospholipase Lipid metabolism 159037052 Common - iron (metal) dependent repressor, DtxR family Sare_1414 77 COG1321 TroR, Mn-dependent transcriptional regulator Transcription 159035701 Common - lipolytic protein G-D-S-L family Sare_0027 20 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 159036543 Nonpathogen - hypothetical protein Sare_0887 1 None None None 159036155 Nonpathogen - hypothetical protein Sare_0488 1 COG3424 BcsA, Predicted naringenin-chalcone synthase Secondary metabolites biosynthesis, transport, and catabolism 159036216 Common - protein of unknown function DUF1702 Sare_0549 3 None None None 159039104 Common - oxidoreductase FAD/NAD(P)-binding domain protein Sare_3564 104 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 159036949 Common - GCN5-related N-acetyltransferase Sare_1310 17 COG3393 COG3393, Predicted acetyltransferase General function prediction only 159035902 Common - hypothetical protein Sare_0229 7 None None None 159038610 Nonpathogen - hypothetical protein Sare_3053 1 None None None 159036816 Nonpathogen - LPXTG-motif cell wall anchor domain Sare_1170 1 None None None 159036347 Nonpathogen - hypothetical protein Sare_0688 1 None None None 159036910 Common - NDP-hexose 23-dehydratase Sare_1267 9 None None None 159036717 Nonpathogen - hypothetical protein Sare_1070 1 COG3889 COG3889, Predicted solute binding protein General function prediction only 159037732 Common - secreted protein Sare_2129 7 None None None 159040380 Common - Kynurenine 3-monooxygenase Sare_4893 83 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 159039533 Common - ABC-2 type transporter Sare_4005 166 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 159037819 Common - AMP-dependent synthetase and ligase Sare_2221 217 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159035748 Common - peptidase M28 Sare_0075 71 COG3227 LasB, Zinc metalloprotease (elastase) Amino acid transport and metabolism 159040154 Common - protein of unknown function DUF6 transmembrane Sare_4663 6 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 159039948 Nonpathogen - hypothetical protein Sare_4436 1 COG3417 FlgN, Collagen-binding surface adhesin SpaP (antigen I/II family) General function prediction only 159036762 Common - hypothetical protein Sare_1116 118 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 159035899 Common - PHP domain protein Sare_0226 68 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 159035678 Common - DNA replication and repair protein RecF Sare_0004 158 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 159038943 Common - ABC drug efflux pump, inner membrane subunit, DrrB family Sare_3403 40 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 159036839 Nonpathogen - protein of unknown function DUF402 Sare_1193 4 None None None 159040387 Common - alpha/beta hydrolase fold Sare_4900 17 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159036197 Common - carbonic anhydrase Sare_0530 131 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 159039003 Common - type I phosphodiesterase/nucleotide pyrophosphatase Sare_3463 38 COG1524 COG1524, Uncharacterized proteins of the AP superfamily General function prediction only 159037612 Nonpathogen - hypothetical protein Sare_1995 1 None None None 159038550 Nonpathogen - hypothetical protein Sare_2988 1 None None None 159037865 Common - oxidoreductase molybdopterin binding Sare_2268 80 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 159036083 Common - phospholipid/glycerol acyltransferase Sare_0416 46 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 159036847 Common - Ribonuclease H Sare_1201 166 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 159038726 Common - carbohydrate kinase FGGY Sare_3181 77 COG1070 XylB, Sugar (pentulose and hexulose) kinases Carbohydrate transport and metabolism 159039414 Common - transcriptional regulator, ArsR family Sare_3885 20 COG1777 COG1777, Predicted transcriptional regulators Transcription 159039739 Common - NUDIX hydrolase Sare_4220 28 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 159039924 Common - hypothetical protein Sare_4409 4 None None None 159039528 Common - 3-hydroxybutyryl-CoA dehydrogenase Sare_4000 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 159039762 Common - peptidase M22 glycoprotease Sare_4243 173 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 159039703 Common - 4-phytase Sare_4176 192 COG4166 OppA, ABC-type oligopeptide transport system, periplasmic component Amino acid transport and metabolism 159036749 Common - Electron transfer flavoprotein alpha/beta-subunit Sare_1103 152 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 159035889 Common - protein of unknown function DUF885 Sare_0216 40 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 159038990 Common - SNARE associated Golgi protein Sare_3450 25 COG0398 COG0398, Uncharacterized conserved protein Function unknown 159040534 Common - GCN5-related N-acetyltransferase Sare_5053 68 COG3153 COG3153, Predicted acetyltransferase General function prediction only 159037098 Nonpathogen - hypothetical protein Sare_1461 1 None None None 159037688 Common - putative hydrolase Sare_2084 11 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 159038767 Common - NmrA family protein Sare_3222 29 COG0702 COG0702, Predicted nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 159037681 Common - Methyltransferase type 12 Sare_2077 10 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 159038715 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Sare_3170 14 COG3565 COG3565, Predicted dioxygenase of extradiol dioxygenase family General function prediction only 159040552 Common - transcriptional regulator, SARP family Sare_5071 13 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 159035683 Common - hypothetical protein Sare_0009 16 None None None 159039964 Common - proton-translocating NADH-quinone oxidoreductase, chain L Sare_4452 209 COG1009 NuoL, NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit Energy production and conversion / Inorganic ion transport and metabolism 159040090 Common - transcriptional regulator, XRE family Sare_4588 40 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 159039090 Common - hypothetical protein Sare_3550 9 None None None 159040250 Common - endonuclease III Sare_4759 237 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 159036211 Common - hypothetical protein Sare_0544 2 None None None 159040331 Common - transcriptional regulator, SARP family Sare_4843 49 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 159037085 Common - nucleic acid binding OB-fold tRNA/helicase-type Sare_1448 11 None None None 159037110 Common - uroporphyrinogen decarboxylase Sare_1474 176 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 159039008 Common - hypothetical protein Sare_3468 7 COG2842 COG2842, Uncharacterized ATPase, putative transposase General function prediction only 159037295 Nonpathogen - secreted protein Sare_1669 8 None None None 159038451 Common - acyl-CoA dehydrogenase domain protein Sare_2887 29 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 159040399 Common - putative DNA-binding protein Sare_4913 2 COG2944 COG2944, Predicted transcriptional regulator Transcription 159036161 Nonpathogen - hypothetical protein Sare_0494 2 None None None 159038398 Common - thioesterase superfamily protein Sare_2825 14 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 159037511 Common - argininosuccinate lyase Sare_1888 215 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 159040418 Common - AMP-dependent synthetase and ligase Sare_4933 222 COG1021 EntE, Peptide arylation enzymes Secondary metabolites biosynthesis, transport, and catabolism 159038908 Common - dephospho-CoA kinase Sare_3368 143 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 159036754 Common - Methionine synthase vitamin-B12 independent Sare_1108 15 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 159039279 Nonpathogen - hypothetical protein Sare_3748 1 None None None 159038299 Common - drug resistance transporter, EmrB/QacA subfamily Sare_2724 210 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159036315 Common - transcriptional regulator, PaaX family Sare_0655 35 COG3327 PaaX, Phenylacetic acid-responsive transcriptional repressor Transcription 159036096 Common - Porphobilinogen synthase Sare_0429 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 159037228 Common - transcriptional regulator, XRE family Sare_1597 6 COG1396 HipB, Predicted transcriptional regulators Transcription 159036962 Nonpathogen - hypothetical protein Sare_1323 1 None None None 159036041 Common - aminotransferase class IV Sare_0374 139 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 159036823 Common - Ribonuclease III Sare_1177 215 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 159038113 Nonpathogen - hypothetical protein Sare_2532 2 None None None 159037039 Common - protein of unknown function DUF349 Sare_1401 27 None None None 159039285 Nonpathogen - hypothetical protein Sare_3754 1 None None None 159039377 Common - DNA polymerase III, delta subunit Sare_3846 21 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 159038458 Common - Rhodanese domain protein Sare_2894 153 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 159038311 Common - hypothetical protein Sare_2738 41 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 159038564 Common - short-chain dehydrogenase/reductase SDR Sare_3002 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 159037558 Nonpathogen - hypothetical protein Sare_1935 2 None None None 159035767 Common - Allophanate hydrolase subunit 1 Sare_0094 99 COG2049 DUR1, Allophanate hydrolase subunit 1 Amino acid transport and metabolism 159038567 Common - KDPG and KHG aldolase Sare_3005 124 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 159038546 Nonpathogen - hypothetical protein Sare_2983 1 None None None 159038830 Common - aconitate hydratase 1 Sare_3289 218 COG1048 AcnA, Aconitase A Energy production and conversion 159039686 Common - protein of unknown function DUF418 Sare_4159 36 COG2311 COG2311, Predicted membrane protein Function unknown 159039970 Common - NADH-quinone oxidoreductase, F subunit Sare_4458 165 COG1894 NuoF, NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit Energy production and conversion 159036051 Common - protein of unknown function DUF540 Sare_0384 10 COG2981 CysZ, Uncharacterized protein involved in cysteine biosynthesis Amino acid transport and metabolism 159036864 Nonpathogen - hypothetical protein Sare_1219 1 None None None 159036874 Common - ribosomal protein S2 Sare_1230 223 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 159037886 Common - hypothetical protein Sare_2290 20 None None None 159039149 Common - 2-oxo-acid dehydrogenase E1 subunit, homodimeric type Sare_3613 152 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 159035796 Common - hypothetical protein Sare_0123 3 None None None 159037025 Common - major facilitator superfamily MFS_1 Sare_1387 11 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 159036271 Common - Protein-L-isoaspartate(D-aspartate) O-methyltransferase Sare_0605 151 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 159038325 Nonpathogen - CDP-alcohol phosphatidyltransferase Sare_2752 12 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 159035957 Common - sugar isomerase (SIS) Sare_0288 162 COG2222 AgaS, Predicted phosphosugar isomerases Cell envelope biogenesis, outer membrane 159035859 Common - copper resistance D domain protein Sare_0186 32 COG3336 COG3336, Predicted membrane protein Function unknown 159038850 Common - FeS assembly protein SufD Sare_3309 174 COG0719 SufB, ABC-type transport system involved in Fe-S cluster assembly, permease component Posttranslational modification, protein turnover, chaperones 159037479 Common - phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase Sare_1856 233 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 159036505 Common - protein of unknown function DUF1112 Sare_0849 28 COG4760 COG4760, Predicted membrane protein Function unknown 159036795 Common - 3-isopropylmalate dehydratase, large subunit Sare_1149 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 159040271 Common - binding-protein-dependent transport systems inner membrane component Sare_4780 220 COG1173 DppC, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 159038921 Common - transcriptional regulator, BadM/Rrf2 family Sare_3381 166 COG1959 COG1959, Predicted transcriptional regulator Transcription 159039813 Common - Adenylate kinase Sare_4294 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 159036132 Common - GCN5-related N-acetyltransferase Sare_0465 30 COG3393 COG3393, Predicted acetyltransferase General function prediction only 159037276 Nonpathogen - hypothetical protein Sare_1648 1 None None None 159037620 Nonpathogen - hypothetical protein Sare_2006 1 None None None 159037548 Common - C-5 cytosine-specific DNA methylase Sare_1925 67 COG0270 Dcm, Site-specific DNA methylase DNA replication, recombination, and repair 159036460 Common - biotin--acetyl-CoA-carboxylase ligase Sare_0803 192 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 159037175 Common - transcriptional regulator, ArsR family Sare_1541 78 COG0640 ArsR, Predicted transcriptional regulators Transcription 159036695 Common - alanine dehydrogenase/PNT domain protein Sare_1048 11 COG0686 Ald, Alanine dehydrogenase Amino acid transport and metabolism 159037076 Common - hypothetical protein Sare_1439 7 None None None 159038631 Nonpathogen - hypothetical protein Sare_3078 1 None None None 159037512 Common - AMP-dependent synthetase and ligase Sare_1889 195 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 159036130 Common - NADH dehydrogenase (ubiquinone) 30 kDa subunit Sare_0463 174 COG0852 NuoC, NADH:ubiquinone oxidoreductase 27 kD subunit Energy production and conversion 159036471 Nonpathogen - hypothetical protein Sare_0814 1 None None None 159038140 Common - AMP-dependent synthetase and ligase Sare_2560 215 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 159037505 Common - arginine biosynthesis bifunctional protein ArgJ Sare_1882 167 COG1364 ArgJ, N-acetylglutamate synthase (N-acetylornithine aminotransferase) Amino acid transport and metabolism 159038171 Common - transcriptional regulator, SARP family Sare_2592 17 COG3629 DnrI, DNA-binding transcriptional activator of the SARP family Signal transduction mechanisms 159037892 Common - SecA DEAD domain protein Sare_2296 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 159039543 Common - ATP synthase F1, delta subunit Sare_4015 77 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 159036146 Common - transcriptional regulator, MerR family Sare_0479 59 COG0789 SoxR, Predicted transcriptional regulators Transcription 159037534 Common - CTP synthase Sare_1911 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 159036251 Common - major facilitator superfamily MFS_1 Sare_0585 28 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 159040143 Common - Na+/Ca+ antiporter, CaCA family Sare_4649 104 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 159037103 Nonpathogen - hypothetical protein Sare_1467 2 None None None 159037619 Nonpathogen - hypothetical protein Sare_2005 2 None None None 159036445 Common - transcriptional regulator, TetR family Sare_0788 37 COG1309 AcrR, Transcriptional regulator Transcription 159039351 Common - alpha/beta hydrolase fold Sare_3820 75 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 159036534 Common - thioesterase superfamily protein Sare_0878 130 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 159036190 Common - hypothetical protein Sare_0523 12 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 159038557 Nonpathogen - hypothetical protein Sare_2995 1 None None None 159039086 Common - cobalamin-5-phosphate synthase CobS Sare_3546 21 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism