Shewanella baltica OS185, complete genome NC_009665 GI_Number Pathogen_associated Gene_name Product Synonym Number_of_Genera COG_Number COG_Description COG_Category 153001057 Common - hypothetical protein Shew185_2538 1 None None None 153000331 Common - hypothetical protein Shew185_1806 1 None None None 152999887 Common - peptidase S9 prolyl oligopeptidase active site domain protein Shew185_1355 101 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 153000154 Common - MotA/TolQ/ExbB proton channel Shew185_1627 87 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 153002219 Common - two component transcriptional regulator, LuxR family Shew185_3713 221 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 153000144 Common - hypothetical protein Shew185_1615 2 COG3110 COG3110, Uncharacterized protein conserved in bacteria Function unknown 152999469 Common - response regulator receiver modulated diguanylate cyclase/phosphodiesterase Shew185_0933 164 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 153002428 Common - regulator of RpoD, Rsd/AlgQ Shew185_3922 24 COG3160 Rsd, Regulator of sigma D Transcription 152999243 Common - hypothetical protein Shew185_0704 1 COG3242 COG3242, Uncharacterized protein conserved in bacteria Function unknown 153000317 Common - thioesterase superfamily protein Shew185_1792 28 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 153000479 Common - hypothetical protein Shew185_1954 4 None None None 153000780 Common - ATP-dependent DNA helicase, RecQ family Shew185_2260 234 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 153001404 Common - phosphoglucosamine mutase Shew185_2888 240 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 152999017 Common - uridine phosphorylase Shew185_0467 97 COG2820 Udp, Uridine phosphorylase Nucleotide transport and metabolism 153000964 Common - Paraquat-inducible protein A Shew185_2445 54 COG2995 PqiA, Uncharacterized paraquat-inducible protein A Function unknown 153000483 Common - hypothetical protein Shew185_1958 14 COG2411 COG2411, Uncharacterized conserved protein Function unknown 152999866 Nonpathogen - hypothetical protein Shew185_1334 1 None None None 153000342 Common - hypothetical protein Shew185_1817 3 None None None 153001421 Common - amino acid/peptide transporter Shew185_2905 80 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 153001280 Common - FAD dependent oxidoreductase Shew185_2764 49 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 153001285 Common - Chorismate synthase Shew185_2769 227 COG0082 AroC, Chorismate synthase Amino acid transport and metabolism 153002620 Common - transcriptional regulator, LysR family Shew185_4121 141 COG0583 LysR, Transcriptional regulator Transcription 153002390 Common - peptidase S9 prolyl oligopeptidase active site domain protein Shew185_3884 105 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 153001996 Common - periplasmic glucan biosynthesis protein MdoG Shew185_3487 50 COG3131 MdoG, Periplasmic glucans biosynthesis protein Inorganic ion transport and metabolism 153001668 Common - 6,7-dimethyl-8-ribityllumazine synthase Shew185_3155 229 COG0054 RibH, Riboflavin synthase beta-chain Coenzyme metabolism 153001610 Common - methyl-accepting chemotaxis sensory transducer Shew185_3097 152 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153000284 Common - hypothetical protein Shew185_1759 44 COG2996 COG2996, Uncharacterized protein conserved in bacteria Function unknown 153002269 Common - ubiquinol-cytochrome c reductase, iron-sulfur subunit Shew185_3763 94 COG0723 QcrA, Rieske Fe-S protein Energy production and conversion 152999534 Common - protein of unknown function DUF214 Shew185_1000 9 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 153002006 Common - FAD dependent oxidoreductase Shew185_3497 141 COG0578 GlpA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 153002115 Common - 2-dehydro-3-deoxyphosphooctonate aldolase Shew185_3608 185 COG2877 KdsA, 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase Cell envelope biogenesis, outer membrane 153000395 Common - hypothetical protein Shew185_1870 6 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 152999947 Common - hypothetical protein Shew185_1415 11 None None None 153001286 Common - modification methylase, HemK family Shew185_2770 219 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 152998980 Common - TonB-dependent receptor Shew185_0430 97 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 153002713 Common - hypothetical protein Shew185_4215 2 None None None 152999669 Common - periplasmic binding protein/LacI transcriptional regulator Shew185_1135 128 COG1609 PurR, Transcriptional regulators Transcription 153000777 Common - cation diffusion facilitator family transporter Shew185_2257 151 COG1230 CzcD, Co/Zn/Cd efflux system component Inorganic ion transport and metabolism 153001400 Common - GAF sensor signal transduction histidine kinase Shew185_2884 218 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153000738 Common - alanine dehydrogenase Shew185_2217 167 COG0686 Ald, Alanine dehydrogenase Amino acid transport and metabolism 152999743 Common - hypothetical protein Shew185_1210 15 None None None 152999363 Common - prepilin-type cleavage/methylation-like protein Shew185_0827 3 COG4966 PilW, Tfp pilus assembly protein PilW Cell motility and secretion / Intracellular trafficking and secretion 153000310 Common - protein of unknown function UPF0118 Shew185_1785 137 COG0628 PerM, Predicted permease General function prediction only 153000597 Common - hypothetical protein Shew185_2073 18 None None None 152999687 Common - aldehyde dehydrogenase Shew185_1153 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 152999893 Common - peptidase M61 domain protein Shew185_1361 56 COG3975 COG3975, Predicted protease with the C-terminal PDZ domain General function prediction only 152998676 Common - multiple antibiotic resistance (MarC)-related protein Shew185_0123 154 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 153001092 Common - GP46 Shew185_2575 6 None None None 153000129 Common - ABC transporter related Shew185_1600 249 COG4167 SapF, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 153000770 Common - SpoIIAA family protein Shew185_2250 11 COG1366 SpoIIAA, Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) Signal transduction mechanisms 153001141 Common - TonB-dependent receptor Shew185_2624 115 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 153001038 Common - MATE efflux family protein Shew185_2519 146 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 153002869 Common - parB-like partition protein Shew185_4373 186 COG1475 Spo0J, Predicted transcriptional regulators Transcription 153002547 Common - acyltransferase 3 Shew185_4047 15 COG1835 COG1835, Predicted acyltransferases Lipid metabolism 153002338 Common - permease Shew185_3832 94 COG0701 COG0701, Predicted permeases General function prediction only 152999599 Common - sulfate ABC transporter, inner membrane subunit CysT Shew185_1065 231 COG0555 CysU, ABC-type sulfate transport system, permease component Posttranslational modification, protein turnover, chaperones 153001207 Common - formate acetyltransferase Shew185_2690 59 COG1882 PflD, Pyruvate-formate lyase Energy production and conversion 152999046 Common - hypothetical protein Shew185_0496 25 None None None 153000081 Nonpathogen - hypothetical protein Shew185_1552 1 None None None 152998646 Common - protein of unknown function DUF347 Shew185_0092 27 COG4705 COG4705, Uncharacterized membrane-anchored protein conserved in bacteria Function unknown 153002076 Common - integral membrane sensor signal transduction histidine kinase Shew185_3568 212 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153000306 Common - hypothetical protein Shew185_1781 8 COG3308 COG3308, Predicted membrane protein Function unknown 152999543 Common - UspA domain protein Shew185_1009 94 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 153000787 Common - major facilitator superfamily MFS_1 Shew185_2267 164 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153001099 Common - Inosine kinase Shew185_2582 61 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 152999303 Common - Phage regulatory protein Rha family Shew185_0764 24 COG3646 COG3646, Uncharacterized phage-encoded protein Function unknown 152999456 Common - sulfite reductase (NADPH) hemoprotein, beta-component Shew185_0920 148 COG0155 CysI, Sulfite reductase, beta subunit (hemoprotein) Inorganic ion transport and metabolism 152999738 Common - aspartate carbamoyltransferase Shew185_1205 240 COG0540 PyrB, Aspartate carbamoyltransferase, catalytic chain Nucleotide transport and metabolism 153002377 Common - NosL family protein Shew185_3871 34 COG4314 NosL, Predicted lipoprotein involved in nitrous oxide reduction Energy production and conversion 153002328 Common - multi-sensor signal transduction histidine kinase Shew185_3822 221 COG4251 COG4251, Bacteriophytochrome (light-regulated signal transduction histidine kinase) Signal transduction mechanisms 152999797 Common - chorismate mutase Shew185_1264 222 COG0077 PheA, Prephenate dehydratase Amino acid transport and metabolism 152999605 Common - two component transcriptional regulator, winged helix family Shew185_1071 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153001737 Common - phosphopentomutase Shew185_3228 70 COG1015 DeoB, Phosphopentomutase Carbohydrate transport and metabolism 152999719 Common - ROK family protein Shew185_1186 129 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 152999898 Common - phosphate binding protein Shew185_1366 110 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 153001168 Common - protein of unknown function DUF124 Shew185_2651 74 COG2013 COG2013, Uncharacterized conserved protein Function unknown 153001797 Common - ATP-dependent metalloprotease FtsH Shew185_3288 249 COG0465 HflB, ATP-dependent Zn proteases Posttranslational modification, protein turnover, chaperones 153001198 Common - chromosome segregation protein SMC Shew185_2681 181 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 152999564 Common - peptidase S10 serine carboxypeptidase Shew185_1030 37 COG2939 COG2939, Carboxypeptidase C (cathepsin A) Amino acid transport and metabolism 152999018 Common - hypothetical protein Shew185_0468 18 COG3248 Tsx, Nucleoside-binding outer membrane protein Cell envelope biogenesis, outer membrane 153001378 Common - hypothetical protein Shew185_2862 4 None None None 153000416 Common - AMP-dependent synthetase and ligase Shew185_1891 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152999645 Common - transaldolase Shew185_1111 172 COG0176 MipB, Transaldolase Carbohydrate transport and metabolism 153001502 Common - protein of unknown function DUF465 Shew185_2989 23 COG2841 COG2841, Uncharacterized protein conserved in bacteria Function unknown 153001640 Common - DNA mismatch repair protein MutS Shew185_3127 205 COG0249 MutS, Mismatch repair ATPase (MutS family) DNA replication, recombination, and repair 153002349 Common - secretion protein HlyD family protein Shew185_3843 169 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 153001070 Nonpathogen - hypothetical protein Shew185_2553 1 None None None 153002040 Common - putative diguanylate cyclase Shew185_3531 4 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153001638 Common - regulatory protein RecX Shew185_3125 47 COG2137 OraA, Uncharacterized protein conserved in bacteria General function prediction only 152999028 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)) Shew185_0478 196 COG0281 SfcA, Malic enzyme Energy production and conversion 153000990 Common - tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Shew185_2471 212 COG0482 TrmU, Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain Translation, ribosomal structure and biogenesis 153002027 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Shew185_3518 247 COG3634 AhpF, Alkyl hydroperoxide reductase, large subunit Posttranslational modification, protein turnover, chaperones 152999662 Common - type IV pilin biogenesis protein, putative Shew185_1128 37 COG3419 PilY1, Tfp pilus assembly protein, tip-associated adhesin PilY1 Cell motility and secretion / Intracellular trafficking and secretion 153000609 Common - hypothetical protein Shew185_2085 1 None None None 153001824 Common - iojap-like protein Shew185_3315 201 COG0799 COG0799, Uncharacterized homolog of plant Iojap protein Function unknown 153001352 Common - acyl-CoA thioesterase II Shew185_2836 77 COG1946 TesB, Acyl-CoA thioesterase Lipid metabolism 152998699 Common - Hsp33 protein Shew185_0146 139 COG1281 COG1281, Disulfide bond chaperones of the HSP33 family Posttranslational modification, protein turnover, chaperones 152998574 Common - potassium uptake protein, TrkH family Shew185_0019 128 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 152999774 Common - sigma E regulatory protein, MucB/RseB Shew185_1241 48 COG3026 RseB, Negative regulator of sigma E activity Signal transduction mechanisms 152999938 Common - hypothetical protein Shew185_1406 1 None None None 152999083 Common - Polysulphide reductase NrfD Shew185_0533 21 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 152999594 Common - hypothetical protein Shew185_1060 11 None None None 153000613 Common - protein of unknown function DUF935 Shew185_2089 28 COG4383 COG4383, Mu-like prophage protein gp29 Function unknown 153001754 Common - hypothetical protein Shew185_3245 38 COG3440 COG3440, Predicted restriction endonuclease Defense mechanisms 153000430 Common - hydrogenase expression/formation protein HypE Shew185_1905 134 COG0309 HypE, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 152998896 Common - ATP-dependent DNA helicase RecG Shew185_0344 230 COG1200 RecG, RecG-like helicase DNA replication, recombination, and repair / Transcription 153001333 Common - dual specificity protein phosphatase Shew185_2817 5 COG2453 CDC14, Predicted protein-tyrosine phosphatase Signal transduction mechanisms 153001955 Common - hypothetical protein Shew185_3446 2 COG5373 COG5373, Predicted membrane protein Function unknown 152999494 Common - sodium/calcium exchanger membrane region Shew185_0959 49 COG0387 ChaA, Ca2+/H+ antiporter Inorganic ion transport and metabolism 153001805 Common - lysozyme Shew185_3296 28 COG3656 COG3656, Predicted periplasmic protein Function unknown 152998802 Common - GAF modulated sigma54 specific transcriptional regulator, Fis family Shew185_0249 178 COG3284 AcoR, Transcriptional activator of acetoin/glycerol metabolism Secondary metabolites biosynthesis, transport, and catabolism / Transcription 153000016 Common - protein of unknown function DUF925 Shew185_1484 21 COG3575 COG3575, Uncharacterized protein conserved in bacteria Function unknown 153000670 Common - phosphoglucomutase, alpha-D-glucose phosphate-specific Shew185_2146 174 COG0033 Pgm, Phosphoglucomutase Carbohydrate transport and metabolism 153002568 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Shew185_4068 209 COG0313 COG0313, Predicted methyltransferases General function prediction only 153002854 Common - naphthoate synthase Shew185_4358 175 COG0447 MenB, Dihydroxynaphthoic acid synthase Coenzyme metabolism 153000444 Common - ApbE family lipoprotein Shew185_1919 134 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 153002862 Common - ATP synthase F1, gamma subunit Shew185_4366 208 COG0224 AtpG, F0F1-type ATP synthase, gamma subunit Energy production and conversion 152999710 Common - tryptophan halogenase Shew185_1176 16 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 153000699 Nonpathogen - hypothetical protein Shew185_2175 2 None None None 153001673 Common - Glycine hydroxymethyltransferase Shew185_3161 245 COG0112 GlyA, Glycine/serine hydroxymethyltransferase Amino acid transport and metabolism 153002696 Common - competence protein ComF Shew185_4198 137 COG1040 ComFC, Predicted amidophosphoribosyltransferases General function prediction only 152998746 Common - translation elongation factor G Shew185_0193 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 152998927 Common - DNA repair protein RadC Shew185_0376 178 COG2003 RadC, DNA repair proteins DNA replication, recombination, and repair 153001340 Common - TRAP dicarboxylate transporter, DctP subunit Shew185_2824 98 COG1638 DctP, TRAP-type C4-dicarboxylate transport system, periplasmic component Carbohydrate transport and metabolism 153002370 Common - conserved hypothetical flavoprotein oxygenase Shew185_3864 83 COG1853 COG1853, Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family General function prediction only 152998922 Common - GTP cyclohydrolase I Shew185_0371 177 COG0302 FolE, GTP cyclohydrolase I Coenzyme metabolism 153001386 Common - lipoprotein, putative Shew185_2870 7 None None None 153002472 Common - HupE/UreJ protein Shew185_3969 47 COG2370 HupE, Hydrogenase/urease accessory protein Posttranslational modification, protein turnover, chaperones 153002260 Common - acetylornithine and succinylornithine aminotransferase Shew185_3754 237 COG4992 ArgD, Ornithine/acetylornithine aminotransferase Amino acid transport and metabolism 152999289 Common - hypothetical protein Shew185_0750 1 None None None 153001821 Common - Rare lipoprotein B Shew185_3312 28 COG2980 RlpB, Rare lipoprotein B Cell envelope biogenesis, outer membrane 153002120 Common - modification methylase, HemK family Shew185_3613 207 COG2890 HemK, Methylase of polypeptide chain release factors Translation, ribosomal structure and biogenesis 153001929 Common - hypothetical protein Shew185_3420 1 None None None 153000987 Common - isocitrate dehydrogenase, NADP-dependent Shew185_2468 65 COG2838 Icd, Monomeric isocitrate dehydrogenase Energy production and conversion 152998690 Nonpathogen - hypothetical protein Shew185_0137 2 None None None 153001529 Common - NrfJ-related protein Shew185_3016 9 None None None 152998944 Common - S-adenosyl-methyltransferase MraW Shew185_0393 215 COG0275 COG0275, Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis Cell envelope biogenesis, outer membrane 153000295 Common - Na+/H+ antiporter NhaB Shew185_1770 26 COG3067 NhaB, Na+/H+ antiporter Inorganic ion transport and metabolism 153000513 Nonpathogen - protein of unknown function DUF952 Shew185_1988 1 COG3502 COG3502, Uncharacterized protein conserved in bacteria Function unknown 153001979 Common - thioesterase superfamily protein Shew185_3470 92 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 153000536 Common - Hydroxyacylglutathione hydrolase Shew185_2011 192 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 152999091 Common - secretion protein HlyD family protein Shew185_0541 110 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 153002507 Common - hypothetical protein Shew185_4004 1 None None None 152999703 Common - Ornithine carbamoyltransferase Shew185_1169 190 COG1177 PotC, ABC-type spermidine/putrescine transport system, permease component II Amino acid transport and metabolism 153001215 Common - hypothetical protein Shew185_2699 1 None None None 153000362 Common - diacylglycerol kinase Shew185_1837 76 COG0818 DgkA, Diacylglycerol kinase Cell envelope biogenesis, outer membrane 153001702 Common - diguanylate cyclase/phosphodiesterase Shew185_3190 172 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 153002542 Common - hypothetical protein Shew185_4042 21 None None None 152999483 Common - putative transcriptional regulator, AsnC family Shew185_0948 144 COG1522 Lrp, Transcriptional regulators Transcription 153000658 Common - putative deoxyguanosinetriphosphate triphosphohydrolase Shew185_2134 159 COG0232 Dgt, dGTP triphosphohydrolase Nucleotide transport and metabolism 152999520 Common - iron-containing alcohol dehydrogenase Shew185_0985 49 COG0371 GldA, Glycerol dehydrogenase and related enzymes Energy production and conversion 152999145 Common - SMC domain protein Shew185_0602 20 COG3910 COG3910, Predicted ATPase General function prediction only 152998562 Common - putative signal transduction protein Shew185_0007 48 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 153001017 Common - magnesium and cobalt transport protein CorA Shew185_2498 156 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 153002720 Common - protoheme IX farnesyltransferase Shew185_4222 164 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 153001480 Common - FlgN family protein Shew185_2967 7 COG3418 COG3418, Flagellar biosynthesis/type III secretory pathway chaperone Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 153002432 Common - hypothetical protein Shew185_3927 6 None None None 153002437 Common - pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase Shew185_3933 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 153000553 Common - glycine betaine/L-proline ABC transporter, ATPase subunit Shew185_2028 249 COG4175 ProV, ABC-type proline/glycine betaine transport system, ATPase component Amino acid transport and metabolism 153000719 Common - type I site-specific deoxyribonuclease, HsdR family Shew185_2197 135 COG0610 COG0610, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 153002124 Common - 4-diphosphocytidyl-2C-methyl-D-erythritol kinase Shew185_3617 192 COG1947 IspE, 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase Lipid metabolism 153002491 Common - diguanylate cyclase/phosphodiesterase Shew185_3988 158 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 153000038 Common - transcriptional regulator, CadC Shew185_1508 56 COG3710 CadC, DNA-binding winged-HTH domains Transcription 153000825 Common - crossover junction endodeoxyribonuclease RuvC Shew185_2305 195 COG0817 RuvC, Holliday junction resolvasome, endonuclease subunit DNA replication, recombination, and repair 153000799 Common - ribosomal protein S1 Shew185_2279 217 COG0539 RpsA, Ribosomal protein S1 Translation, ribosomal structure and biogenesis 152998705 Common - general secretion pathway protein G Shew185_0152 107 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 153001296 Common - fatty acid oxidation complex, alpha subunit FadJ Shew185_2780 160 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 153001132 Common - DNA polymerase III, subunits gamma and tau Shew185_2615 242 COG2812 DnaX, DNA polymerase III, gamma/tau subunits DNA replication, recombination, and repair 152999420 Common - adenylate cyclase Shew185_0884 58 COG3025 COG3025, Uncharacterized conserved protein Function unknown 152999182 Nonpathogen - hypothetical protein Shew185_0639 1 None None None 153000380 Common - hypothetical protein Shew185_1855 2 None None None 152999392 Common - hypothetical protein Shew185_0856 7 None None None 153002180 Common - hypothetical protein Shew185_3673 8 None None None 153000815 Common - L-asparaginase, type I Shew185_2295 137 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 153001381 Common - Electron transfer flavoprotein alpha subunit Shew185_2865 153 COG2025 FixB, Electron transfer flavoprotein, alpha subunit Energy production and conversion 152999394 Common - anti-ECFsigma factor, ChrR Shew185_0858 38 COG3806 ChrR, Transcriptional activator Transcription 153001474 Common - flagellar basal-body rod protein FlgC Shew185_2961 126 COG1558 FlgC, Flagellar basal body rod protein Cell motility and secretion 153001885 Nonpathogen - hypothetical protein Shew185_3376 1 None None None 153002201 Common - hypothetical protein Shew185_3694 2 None None None 152998933 Common - thioesterase superfamily protein Shew185_0382 49 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 152998766 Common - ribosomal protein S5 Shew185_0213 248 COG0098 RpsE, Ribosomal protein S5 Translation, ribosomal structure and biogenesis 153001077 Nonpathogen - hypothetical protein Shew185_2560 1 None None None 153000876 Common - alpha/beta hydrolase fold Shew185_2356 96 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153000153 Common - MotA/TolQ/ExbB proton channel Shew185_1626 134 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 153001243 Common - tryptophan synthase, alpha subunit Shew185_2727 214 COG0159 TrpA, Tryptophan synthase alpha chain Amino acid transport and metabolism 153002251 Common - 2'-5' RNA ligase Shew185_3745 31 COG1514 LigT, 2'-5' RNA ligase Translation, ribosomal structure and biogenesis 153002585 Common - Pilus assembly protein PilP Shew185_4086 37 COG3168 PilP, Tfp pilus assembly protein PilP Cell motility and secretion / Intracellular trafficking and secretion 152998636 Common - glutathione-dependent formaldehyde-activating GFA Shew185_0081 53 COG3791 COG3791, Uncharacterized conserved protein Function unknown 153000743 Common - threonyl-tRNA synthetase Shew185_2222 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153001025 Common - succinyl-CoA synthetase, beta subunit Shew185_2506 206 COG0045 SucC, Succinyl-CoA synthetase, beta subunit Energy production and conversion 153000261 Common - OmpA/MotB domain protein Shew185_1736 123 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 153000580 Common - Ferric reductase-like transmembrane component domain protein Shew185_2056 77 COG2717 COG2717, Predicted membrane protein Function unknown 152999551 Common - periplasmic binding protein Shew185_1017 105 COG4558 ChuT, ABC-type hemin transport system, periplasmic component Inorganic ion transport and metabolism 153002411 Common - peptidylprolyl isomerase FKBP-type Shew185_3905 146 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 153000955 Common - protein of unknown function DUF1329 Shew185_2436 18 None None None 153000710 Nonpathogen - hypothetical protein Shew185_2188 1 None None None 152999432 Common - transcriptional regulator, LysR family Shew185_0896 185 COG0583 LysR, Transcriptional regulator Transcription 153000492 Common - hypothetical protein Shew185_1967 2 None None None 153000690 Common - hypothetical protein Shew185_2166 22 COG3198 COG3198, Uncharacterized protein conserved in bacteria Function unknown 153001924 Common - gamma-glutamyl phosphate reductase Shew185_3415 189 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 153002759 Common - hypothetical protein Shew185_4261 4 None None None 153002490 Common - hypothetical protein Shew185_3987 32 COG3672 COG3672, Predicted periplasmic protein Function unknown 153001617 Common - hypothetical protein Shew185_3104 13 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 152998797 Common - hypothetical protein Shew185_0244 7 None None None 153002282 Common - phosphatidylserine decarboxylase Shew185_3776 98 COG0688 Psd, Phosphatidylserine decarboxylase Lipid metabolism 152999768 Common - transcriptional regulator, LysR family Shew185_1235 116 COG0583 LysR, Transcriptional regulator Transcription 153001373 Common - glucose sorbosone dehydrogenase Shew185_2857 119 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 153002294 Common - multi-sensor hybrid histidine kinase Shew185_3788 226 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153002593 Common - acetylglutamate kinase Shew185_4094 212 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 153001434 Common - response regulator receiver protein Shew185_2918 225 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153000072 Common - HNH endonuclease Shew185_1543 26 None None None 153001462 Common - flagellin domain protein Shew185_2948 123 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 152999377 Common - Curlin associated repeat protein Shew185_0841 52 None None None 152998587 Common - Sua5/YciO/YrdC/YwlC family protein Shew185_0032 239 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 153002403 Common - hypothetical protein Shew185_3897 6 None None None 153002735 Common - MotA/TolQ/ExbB proton channel Shew185_4237 92 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 153000050 Nonpathogen - hypothetical protein Shew185_1520 3 None None None 152999951 Common - Erythronolide synthase Shew185_1419 210 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 152999674 Common - protein of unknown function DUF81 Shew185_1140 30 COG0730 COG0730, Predicted permeases General function prediction only 153002049 Common - transketolase Shew185_3540 221 COG0021 TktA, Transketolase Carbohydrate transport and metabolism 153002199 Common - binding-protein-dependent transport systems inner membrane component Shew185_3692 185 COG1178 ThiP, ABC-type Fe3+ transport system, permease component Inorganic ion transport and metabolism 153002056 Common - hypothetical protein Shew185_3547 1 None None None 153000764 Common - Protein-glutamate O-methyltransferase Shew185_2244 150 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 153000702 Common - hypothetical protein Shew185_2178 5 None None None 153000253 Common - HAD-superfamily hydrolase, subfamily IIA Shew185_1728 98 COG0647 NagD, Predicted sugar phosphatases of the HAD superfamily Carbohydrate transport and metabolism 152998558 Common - DNA replication and repair protein RecF Shew185_0003 167 COG1195 RecF, Recombinational DNA repair ATPase (RecF pathway) DNA replication, recombination, and repair 153002230 Common - hypothetical protein Shew185_3724 2 None None None 153000559 Common - alpha amylase catalytic region Shew185_2035 56 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 153002136 Common - Glutathione S-transferase domain Shew185_3629 106 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 153000611 Common - hypothetical protein Shew185_2087 10 None None None 153001747 Common - CRISPR-associated protein, Csy2 family Shew185_3238 18 None None None 153001118 Common - methyl-accepting chemotaxis sensory transducer Shew185_2601 151 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153002483 Common - protein of unknown function DUF513 hemX Shew185_3980 55 COG2959 HemX, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 153001405 Common - phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I Shew185_2889 237 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 152999922 Common - hypothetical protein Shew185_1390 4 None None None 153001818 Common - histidine kinase Shew185_3309 21 COG3897 COG3897, Predicted methyltransferase General function prediction only 153002650 Common - Polysulphide reductase NrfD Shew185_4151 26 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 152999650 Common - peptidase M28 Shew185_1116 49 COG2234 Iap, Predicted aminopeptidases General function prediction only 152999370 Common - amino acid carrier protein Shew185_0834 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 152998629 Common - hypothetical protein Shew185_0074 1 None None None 153001782 Common - phage integrase family protein Shew185_3273 100 COG0582 XerC, Integrase DNA replication, recombination, and repair 153001721 Common - Trimethylamine N-oxide reductase system TorE Shew185_3211 2 COG4459 NapE, Periplasmic nitrate reductase system, NapE component Energy production and conversion 152999158 Common - succinate dehydrogenase or fumarate reductase, flavoprotein subunit Shew185_0615 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 153002647 Common - TonB family protein Shew185_4148 39 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 153002079 Common - MltA-interacting MipA family protein Shew185_3571 7 COG3713 OmpV, Outer membrane protein V Cell envelope biogenesis, outer membrane 152998912 Common - type III restriction protein res subunit Shew185_0360 149 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 153000055 Common - transposase IS116/IS110/IS902 family protein Shew185_1525 97 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 152999503 Common - aldehyde oxidase and xanthine dehydrogenase molybdopterin binding Shew185_0968 100 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 153000524 Common - isoaspartyl dipeptidase Shew185_1999 21 COG0044 PyrC, Dihydroorotase and related cyclic amidohydrolases Nucleotide transport and metabolism 152999585 Common - Nucleotidyl transferase Shew185_1051 223 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 152998669 Common - hypothetical protein Shew185_0116 1 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 153000469 Common - hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit Shew185_1944 148 COG1951 TtdA, Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain Energy production and conversion 153000999 Common - FAD linked oxidase domain protein Shew185_2480 200 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 152998809 Common - cation diffusion facilitator family transporter Shew185_0256 211 COG0053 MMT1, Predicted Co/Zn/Cd cation transporters Inorganic ion transport and metabolism 152998569 Common - diguanylate cyclase Shew185_0014 179 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152999928 Common - Beta-N-acetylhexosaminidase Shew185_1396 52 COG3525 Chb, N-acetyl-beta-hexosaminidase Carbohydrate transport and metabolism 153001522 Common - protein of unknown function DUF21 Shew185_3009 218 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 153001696 Common - transmembrane pair domain protein Shew185_3184 40 COG4125 COG4125, Predicted membrane protein Function unknown 153001135 Nonpathogen - hypothetical protein Shew185_2618 1 None None None 153002538 Common - protein of unknown function UPF0061 Shew185_4038 110 COG0397 COG0397, Uncharacterized conserved protein Function unknown 153001974 Common - aromatic amino acid permease Shew185_3465 31 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 152999036 Common - Tetratricopeptide TPR_2 repeat protein Shew185_0486 40 COG5010 TadD, Flp pilus assembly protein TadD, contains TPR repeats Intracellular trafficking and secretion 153002019 Common - PepSY-associated TM helix Shew185_3510 10 None None None 152999261 Common - hypothetical protein Shew185_0722 1 None None None 152999345 Common - rRNA (guanine-N(2)-)-methyltransferase Shew185_0806 102 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 153002841 Common - DNA polymerase I Shew185_4345 216 COG0749 PolA, DNA polymerase I - 3'-5' exonuclease and polymerase domains DNA replication, recombination, and repair 153000582 Common - hypothetical protein Shew185_2058 1 None None None 153001255 Nonpathogen - hypothetical protein Shew185_2739 3 None None None 153000733 Common - CrcB protein Shew185_2212 184 COG0239 CrcB, Integral membrane protein possibly involved in chromosome condensation Cell division and chromosome partitioning 152998903 Common - (p)ppGpp synthetase I, SpoT/RelA Shew185_0351 207 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 152998975 Common - hypothetical protein Shew185_0424 23 COG1819 COG1819, Glycosyl transferases, related to UDP-glucuronosyltransferase Carbohydrate transport and metabolism / Signal transduction mechanisms 153002611 Common - formate dehydrogenase, gamma subunit Shew185_4112 65 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 153000571 Common - exodeoxyribonuclease V, beta subunit Shew185_2047 221 COG1074 RecB, ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) DNA replication, recombination, and repair 153001054 Common - tetraheme cytochrome c, putative Shew185_2535 4 None None None 153001240 Common - anthranilate phosphoribosyltransferase Shew185_2724 217 COG0547 TrpD, Anthranilate phosphoribosyltransferase Amino acid transport and metabolism 152998759 Common - ribosomal protein L14 Shew185_0206 248 COG0093 RplN, Ribosomal protein L14 Translation, ribosomal structure and biogenesis 153001014 Common - integral membrane sensor signal transduction histidine kinase Shew185_2495 211 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153001894 Common - SEC-C motif domain protein Shew185_3385 27 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 153000247 Common - Aldose 1-epimerase Shew185_1722 55 COG0676 COG0676, Uncharacterized enzymes related to aldose 1-epimerase Carbohydrate transport and metabolism 153001484 Common - protein of unknown function DUF115 Shew185_2971 17 COG2604 COG2604, Uncharacterized protein conserved in bacteria Function unknown 152999759 Common - putative adenylate/guanylate cyclase Shew185_1226 8 COG2114 CyaA, Adenylate cyclase, family 3 (some proteins contain HAMP domain) Signal transduction mechanisms 152998595 Common - protein of unknown function DUF610 YibQ Shew185_0040 63 COG2861 COG2861, Uncharacterized protein conserved in bacteria Function unknown 153000408 Common - 2OG-Fe(II) oxygenase Shew185_1883 55 COG3491 PcbC, Isopenicillin N synthase and related dioxygenases General function prediction only 153000311 Common - cytochrome c3 Shew185_1786 2 None None None 153002580 Common - DNA adenine methylase Shew185_4081 97 COG0338 Dam, Site-specific DNA methylase DNA replication, recombination, and repair 153000454 Common - surface antigen (D15) Shew185_1929 120 COG0729 COG0729, Outer membrane protein Cell envelope biogenesis, outer membrane 152999505 Common - protein of unknown function DUF262 Shew185_0970 41 None None None 152998983 Common - pseudouridine synthase Shew185_0433 210 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 153001780 Common - GP46 Shew185_3271 7 None None None 153002474 Common - tyrosine recombinase XerC Shew185_3971 226 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 153002652 Common - formate-dependent nitrite reductase Shew185_4153 18 None None None 153001963 Common - protein of unknown function DUF6 transmembrane Shew185_3454 97 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 152998643 Common - hypothetical protein Shew185_0088 8 None None None 152999224 Common - sigma 54 modulation protein/ribosomal protein S30EA Shew185_0685 130 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 153000285 Common - hypothetical protein Shew185_1760 1 None None None 153002618 Common - hypothetical protein Shew185_4119 7 COG2251 COG2251, Predicted nuclease (RecB family) General function prediction only 153000959 Common - carboxyl-terminal protease Shew185_2440 183 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 152999317 Common - protein of unknown function DUF461 Shew185_0778 77 COG2847 COG2847, Uncharacterized protein conserved in bacteria Function unknown 153001273 Common - Sporulation domain protein Shew185_2757 23 COG3147 DedD, Uncharacterized protein conserved in bacteria Function unknown 153002683 Common - hypothetical protein Shew185_4185 47 COG3346 COG3346, Uncharacterized conserved protein Function unknown 152998726 Common - selenide, water dikinase Shew185_0173 132 COG0709 SelD, Selenophosphate synthase Amino acid transport and metabolism 153002773 Common - AAA ATPase central domain protein Shew185_4276 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 152998724 Common - phospholipid/glycerol acyltransferase Shew185_0171 170 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 153000641 Common - Pyridoxal-5'-phosphate-dependent protein beta subunit Shew185_2117 215 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 153000368 Common - hypothetical protein Shew185_1843 2 None None None 153002788 Nonpathogen - hypothetical protein Shew185_4292 1 None None None 153001745 Common - CRISPR-associated protein, Csy4 family Shew185_3236 19 None None None 153000192 Common - NnrS family protein Shew185_1665 57 COG3213 NnrS, Uncharacterized protein involved in response to NO Inorganic ion transport and metabolism 153002362 Common - short-chain dehydrogenase/reductase SDR Shew185_3856 73 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 153001586 Common - mercuric transport protein MerT, putative Shew185_3073 7 None None None 152999115 Common - UDP-glucose/GDP-mannose dehydrogenase Shew185_0568 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 153001347 Common - transcriptional regulator, LysR family Shew185_2831 165 COG0583 LysR, Transcriptional regulator Transcription 153002750 Common - hypothetical protein Shew185_4252 29 None None None 152998784 Common - cytochrome c-type biogenesis protein CcmF Shew185_0231 137 COG1138 CcmF, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 153002730 Common - anti-FecI sigma factor, FecR Shew185_4232 44 COG3712 FecR, Fe2+-dicitrate sensor, membrane component Inorganic ion transport and metabolism / Signal transduction mechanisms 153000421 Common - protein of unknown function DUF709 Shew185_1896 34 COG3100 COG3100, Uncharacterized protein conserved in bacteria Function unknown 153002522 Common - transcriptional regulator, GntR family Shew185_4020 141 COG1802 GntR, Transcriptional regulators Transcription 152999986 Common - outer membrane chaperone Skp (OmpH) Shew185_1454 84 COG2825 HlpA, Outer membrane protein Cell envelope biogenesis, outer membrane 152998750 Common - ribosomal protein L4/L1e Shew185_0197 216 COG0088 RplD, Ribosomal protein L4 Translation, ribosomal structure and biogenesis 153000184 Common - carbon starvation protein CstA Shew185_1657 109 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 153001294 Common - transposase Shew185_2778 9 None None None 152999252 Common - ribosomal protein S18 Shew185_0713 214 COG0238 RpsR, Ribosomal protein S18 Translation, ribosomal structure and biogenesis 152999535 Common - two component, sigma54 specific, transcriptional regulator, Fis family Shew185_1001 208 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153000831 Common - protein of unknown function DUF785 Shew185_2311 32 COG4067 COG4067, Uncharacterized protein conserved in archaea Posttranslational modification, protein turnover, chaperones 153002067 Common - NADH:ubiquinone oxidoreductase, subunit F Shew185_3559 163 COG2871 NqrF, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF Energy production and conversion 152999973 Common - metal dependent phosphohydrolase Shew185_1441 126 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 153000731 Common - hypothetical protein Shew185_2210 1 None None None 153002757 Common - glutathione-disulfide reductase Shew185_4259 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 153002514 Common - transcriptional regulator, LysR family Shew185_4011 184 COG0583 LysR, Transcriptional regulator Transcription 153000947 Common - hypothetical protein Shew185_2428 27 None None None 153001765 Common - replication P family protein Shew185_3256 8 None None None 153000679 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Shew185_2155 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 153002112 Common - ammonium transporter Shew185_3605 201 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 153001573 Common - hypothetical protein Shew185_3060 36 None None None 153000195 Common - lipid A ABC exporter, fused ATPase and inner membrane subunits MsbA Shew185_1668 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 153002782 Common - TonB-dependent siderophore receptor Shew185_4286 110 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 152999029 Common - diguanylate cyclase/phosphodiesterase Shew185_0479 157 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152998612 Common - protein of unknown function DUF81 Shew185_0057 34 COG0730 COG0730, Predicted permeases General function prediction only 153000207 Common - Exodeoxyribonuclease I Shew185_1680 51 COG2925 SbcB, Exonuclease I DNA replication, recombination, and repair 153002764 Common - YD repeat protein Shew185_4267 59 COG3209 RhsA, Rhs family protein Cell envelope biogenesis, outer membrane 153002839 Common - Rhomboid family protein Shew185_4343 60 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 153000499 Common - transcriptional regulator, XRE family Shew185_1974 2 COG1396 HipB, Predicted transcriptional regulators Transcription 153000241 Common - 3-oxoacyl-(acyl-carrier-protein) reductase Shew185_1716 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153000061 Common - protein of unknown function DUF6 transmembrane Shew185_1531 113 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 153001304 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Shew185_2788 169 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152999237 Common - UDP-N-acetylglucosamine 1-carboxyvinyltransferase Shew185_0698 218 COG0766 MurA, UDP-N-acetylglucosamine enolpyruvyl transferase Cell envelope biogenesis, outer membrane 152999832 Common - protein of unknown function UPF0125 Shew185_1300 55 COG2914 COG2914, Uncharacterized protein conserved in bacteria Function unknown 153002742 Common - Lytic transglycosylase catalytic Shew185_4244 174 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 153001544 Common - hypothetical protein Shew185_3031 23 None None None 153001916 Common - hypothetical protein Shew185_3407 2 None None None 153002819 Common - hypothetical protein Shew185_4323 1 None None None 153001566 Common - A/G-specific adenine glycosylase Shew185_3053 233 COG1194 MutY, A/G-specific DNA glycosylase DNA replication, recombination, and repair 152998880 Common - Beta-ketoacyl synthase Shew185_0328 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152998788 Common - hypothetical protein Shew185_0235 31 COG3812 COG3812, Uncharacterized protein conserved in bacteria Function unknown 153000474 Common - multiple antibiotic resistance (MarC)-related protein Shew185_1949 158 COG2095 MarC, Multiple antibiotic transporter Intracellular trafficking and secretion 153001866 Common - KAP P-loop domain protein Shew185_3357 32 COG4928 COG4928, Predicted P-loop ATPase General function prediction only 153001233 Common - pseudouridine synthase Shew185_2717 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 152998689 Common - Excinuclease ABC C subunit domain protein Shew185_0136 77 COG2827 COG2827, Predicted endonuclease containing a URI domain DNA replication, recombination, and repair 152999914 Common - PhnA protein Shew185_1382 96 COG2824 PhnA, Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism Inorganic ion transport and metabolism 153000864 Common - DNA polymerase III, epsilon subunit Shew185_2344 187 COG2176 PolC, DNA polymerase III, alpha subunit (gram-positive type) DNA replication, recombination, and repair 152998585 Common - protein of unknown function DUF494 Shew185_0030 39 COG2922 Smg, Uncharacterized protein conserved in bacteria Function unknown 152999443 Common - peptidase M16 domain protein Shew185_0907 196 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 152998850 Common - transcriptional regulator, TetR family Shew185_0297 78 COG1309 AcrR, Transcriptional regulator Transcription 153000638 Common - Rhomboid family protein Shew185_2114 11 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 153000883 Common - 3-deoxy-D-manno-octulosonate cytidylyltransferase Shew185_2363 152 COG1212 KdsB, CMP-2-keto-3-deoxyoctulosonic acid synthetase Cell envelope biogenesis, outer membrane 153001217 Common - hypothetical protein Shew185_2701 132 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 153001685 Common - protein of unknown function DUF6 transmembrane Shew185_3173 75 None None None 152999310 Common - hypothetical protein Shew185_0771 2 None None None 153002208 Common - hypothetical protein Shew185_3701 1 None None None 152999207 Common - transcriptional regulator, AraC family Shew185_0667 113 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 153000212 Nonpathogen - hypothetical protein Shew185_1686 1 None None None 153001034 Common - acriflavin resistance protein Shew185_2515 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 153000726 Common - protein of unknown function UPF0005 Shew185_2205 126 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 152999576 Common - hypothetical protein Shew185_1042 4 None None None 152999143 Nonpathogen - hypothetical protein Shew185_0600 1 None None None 153000046 Common - signal peptidase I Shew185_1516 198 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 152999197 Common - hypothetical protein Shew185_0657 5 COG1433 COG1433, Uncharacterized conserved protein Function unknown 153002221 Common - Mg2 transporter protein CorA family protein Shew185_3715 81 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 153001062 Common - methyl-accepting chemotaxis sensory transducer Shew185_2544 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153000328 Common - GCN5-related N-acetyltransferase Shew185_1803 105 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 153001968 Common - hypothetical protein Shew185_3459 8 None None None 153001667 Common - NusB antitermination factor Shew185_3154 199 COG0781 NusB, Transcription termination factor Transcription 152999518 Common - periplasmic binding protein Shew185_0983 136 COG0614 FepB, ABC-type Fe3+-hydroxamate transport system, periplasmic component Inorganic ion transport and metabolism 153000108 Common - decaheme cytochrome c Shew185_1579 8 None None None 153000817 Common - transposase Shew185_2297 9 None None None 152998847 Common - hypothetical protein Shew185_0294 6 None None None 152999180 Common - CutA1 divalent ion tolerance protein Shew185_0637 120 COG1324 CutA, Uncharacterized protein involved in tolerance to divalent cations Inorganic ion transport and metabolism 153001740 Common - nucleoside-specific channel-forming protein Tsx Shew185_3231 22 COG3248 Tsx, Nucleoside-binding outer membrane protein Cell envelope biogenesis, outer membrane 152998681 Common - protein of unknown function DUF333 Shew185_0128 21 COG3042 Hlx, Putative hemolysin General function prediction only 153002672 Common - ribonuclease T2 Shew185_4174 39 COG3719 Rna, Ribonuclease I Translation, ribosomal structure and biogenesis 153001249 Common - TonB-dependent siderophore receptor Shew185_2733 106 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 153001181 Common - Peptidyl-dipeptidase Dcp Shew185_2664 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 152999431 Common - protein of unknown function DUF897 Shew185_0895 31 COG3329 COG3329, Predicted permease General function prediction only 153002823 Common - glycosyl transferase family 2 Shew185_4327 197 COG0463 WcaA, Glycosyltransferases involved in cell wall biogenesis Cell envelope biogenesis, outer membrane 152999327 Common - DNA topoisomerase IV, A subunit Shew185_0788 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 152999953 Common - 4'-phosphopantetheinyl transferase Shew185_1421 57 COG2091 Sfp, Phosphopantetheinyl transferase Coenzyme metabolism 153000748 Common - hypothetical protein Shew185_2227 1 None None None 153002307 Nonpathogen - hypothetical protein Shew185_3801 1 None None None 152999708 Common - amino acid/peptide transporter Shew185_1174 81 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 153001926 Common - Xanthine/uracil/vitamin C permease Shew185_3417 134 COG2252 COG2252, Permeases General function prediction only 153002598 Common - DNA binding domain, excisionase family Shew185_4099 60 COG1910 COG1910, Periplasmic molybdate-binding protein/domain Inorganic ion transport and metabolism 152999022 Common - hypothetical protein Shew185_0472 1 None None None 152998961 Common - Porphobilinogen synthase Shew185_0410 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 153000465 Common - asparaginyl-tRNA synthetase Shew185_1940 217 COG0017 AsnS, Aspartyl/asparaginyl-tRNA synthetases Translation, ribosomal structure and biogenesis 153001907 Common - extracellular solute-binding protein, family 3 Shew185_3398 21 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 153000163 Common - protein of unknown function DUF1260 Shew185_1636 4 None None None 153001579 Common - short-chain dehydrogenase/reductase SDR Shew185_3066 231 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152999413 Common - protein of unknown function DUF599 Shew185_0877 27 COG3821 COG3821, Predicted membrane protein Function unknown 152999697 Common - Cupin 2 conserved barrel domain protein Shew185_1163 98 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 153000097 Common - hypothetical protein Shew185_1568 9 None None None 153002872 Common - glucose inhibited division protein A Shew185_4376 192 COG0445 GidA, NAD/FAD-utilizing enzyme apparently involved in cell division Cell division and chromosome partitioning 152999173 Common - Microbial collagenase Shew185_0630 16 None None None 153002640 Common - methyl-accepting chemotaxis sensory transducer Shew185_4141 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153002607 Common - formate dehydrogenase, gamma subunit Shew185_4108 51 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 152999770 Common - hypothetical protein Shew185_1237 1 None None None 153001315 Common - peptidase S8 and S53 subtilisin kexin sedolisin Shew185_2799 126 COG4935 COG4935, Regulatory P domain of the subtilisin-like proprotein convertases and other proteases Posttranslational modification, protein turnover, chaperones 153002032 Common - thiol:disulfide interchange protein DsbC Shew185_3523 67 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 153000568 Common - diguanylate cyclase Shew185_2044 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153002705 Common - integral membrane sensor signal transduction histidine kinase Shew185_4207 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153002275 Common - DNA mismatch repair protein MutL Shew185_3769 191 COG0323 MutL, DNA mismatch repair enzyme (predicted ATPase) DNA replication, recombination, and repair 153001111 Common - transcriptional regulator, LysR family Shew185_2594 126 COG0583 LysR, Transcriptional regulator Transcription 153002465 Common - fumarate reductase respiratory complex transmembrane subunit Shew185_3962 10 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 153002062 Common - peptidase S45 penicillin amidase Shew185_3553 58 COG2366 COG2366, Protein related to penicillin acylase General function prediction only 153002080 Nonpathogen - hypothetical protein Shew185_3572 1 None None None 152998575 Common - Protoporphyrinogen oxidase Shew185_0020 30 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 152998714 Common - Aspartyl/Asparaginyl beta-hydroxylase Shew185_0161 12 COG0662 {ManC}, Mannose-6-phosphate isomerase Carbohydrate transport and metabolism 153000978 Common - Auxin Efflux Carrier Shew185_2459 146 COG0679 COG0679, Predicted permeases General function prediction only 153000294 Common - Disulphide bond formation protein DsbB Shew185_1769 61 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 153000792 Common - acyl-CoA dehydrogenase domain protein Shew185_2272 150 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 153000545 Common - glutamine amidotransferase class-II Shew185_2020 74 COG0121 COG0121, Predicted glutamine amidotransferase General function prediction only 153001652 Common - Agmatine deiminase Shew185_3139 87 COG2957 COG2957, Peptidylarginine deiminase and related enzymes Amino acid transport and metabolism 153002164 Common - Alpha/beta hydrolase fold-3 domain protein Shew185_3657 138 COG0657 Aes, Esterase/lipase Lipid metabolism 153002175 Common - hypothetical protein Shew185_3668 3 None None None 152999545 Common - extracellular solute-binding protein family 3 Shew185_1011 13 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 152998884 Common - hypothetical protein Shew185_0332 17 None None None 153000904 Common - iron-sulfur cluster assembly protein IscA Shew185_2384 162 COG0316 IscA, Uncharacterized conserved protein Function unknown 153002843 Common - cytochrome c class I Shew185_4347 64 COG2863 COG2863, Cytochrome c553 Energy production and conversion 152999333 Common - hypothetical protein Shew185_0794 3 None None None 152998970 Common - ubiquinone/menaquinone biosynthesis methyltransferase Shew185_0419 222 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153000980 Common - 17 kDa surface antigen Shew185_2461 28 COG3133 SlyB, Outer membrane lipoprotein Cell envelope biogenesis, outer membrane 153002300 Common - diguanylate cyclase Shew185_3794 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153002383 Common - cytochrome c, putative Shew185_3877 8 None None None 152999647 Common - Phosphoketolase Shew185_1113 66 COG3957 COG3957, Phosphoketolase Carbohydrate transport and metabolism 153000626 Common - hypothetical protein Shew185_2102 4 None None None 153000013 Common - transcriptional regulator, TyrR Shew185_1481 168 COG3283 TyrR, Transcriptional regulator of aromatic amino acids metabolism Transcription / Amino acid transport and metabolism 153001173 Common - Lysine exporter protein (LYSE/YGGA) Shew185_2656 91 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 152999164 Common - peptidase M16 domain protein Shew185_0621 191 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 153001945 Common - NADH:ubiquinone oxidoreductase, subunit C Shew185_3436 46 COG2869 NqrC, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC Energy production and conversion 152999484 Common - ABC transporter related Shew185_0949 249 COG1126 GlnQ, ABC-type polar amino acid transport system, ATPase component Amino acid transport and metabolism 153000230 Common - putative cold-shock DNA-binding domain protein Shew185_1705 181 COG1278 CspC, Cold shock proteins Transcription 153000229 Common - rRNA (guanine-N(1)-)-methyltransferase Shew185_1704 63 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153000175 Common - transcriptional regulator, MarR family Shew185_1648 113 COG1846 MarR, Transcriptional regulators Transcription 152999625 Common - sodium pump decarboxylase, gamma subunit Shew185_1091 5 COG3630 OadG, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, gamma subunit Energy production and conversion 153000515 Common - hypothetical protein Shew185_1990 21 None None None 153000022 Common - methylmalonate-semialdehyde dehydrogenase Shew185_1490 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 152998894 Common - hypothetical protein Shew185_0342 36 None None None 153002518 Common - Mg chelatase, subunit ChlI Shew185_4016 196 COG0606 COG0606, Predicted ATPase with chaperone activity Posttranslational modification, protein turnover, chaperones 153002636 Common - DTW domain containing protein Shew185_4137 39 COG3148 COG3148, Uncharacterized conserved protein Function unknown 152998658 Common - selenocysteine-specific translation elongation factor Shew185_0105 249 COG3276 SelB, Selenocysteine-specific translation elongation factor Translation, ribosomal structure and biogenesis 153000383 Common - putative replication protein Shew185_1858 13 None None None 153001770 Nonpathogen - hypothetical protein Shew185_3261 1 None None None 153000007 Common - protein of unknown function DUF583 Shew185_1475 32 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 153001430 Common - hypothetical protein Shew185_2914 1 None None None 153001446 Common - flagellar basal body-associated protein FliL Shew185_2930 17 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 153000891 Common - putative transcriptional regulator, GntR family Shew185_2371 185 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 153001710 Common - hypothetical protein Shew185_3198 1 COG3371 COG3371, Predicted membrane protein Function unknown 152998867 Common - alpha/beta hydrolase fold Shew185_0315 97 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153000405 Common - Domain of unknown function DUF1814 Shew185_1880 20 COG2253 COG2253, Uncharacterized conserved protein Function unknown 153001559 Common - putative oxygen-independent coproporphyrinogen III oxidase Shew185_3046 205 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 152999124 Common - virulence plasmid 65kDa B protein Shew185_0577 13 None None None 152998717 Common - GCN5-related N-acetyltransferase Shew185_0164 27 COG0456 RimI, Acetyltransferases General function prediction only 153002715 Common - hypothetical protein Shew185_4217 1 None None None 152998655 Common - formate dehydrogenase, gamma subunit Shew185_0102 65 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 153002627 Common - peptidase S9 prolyl oligopeptidase active site domain protein Shew185_4128 115 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 152998651 Common - urocanate hydratase Shew185_0097 97 COG2987 HutU, Urocanate hydratase Amino acid transport and metabolism 153000337 Common - protein of unknown function DUF1568 Shew185_1812 17 None None None 153002781 Common - gamma-glutamyl phosphate reductase Shew185_4285 187 COG0014 ProA, Gamma-glutamyl phosphate reductase Amino acid transport and metabolism 153001397 Common - NADH:flavin oxidoreductase/NADH oxidase Shew185_2881 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 153001815 Common - CBS domain containing protein Shew185_3306 220 COG4535 CorC, Putative Mg2+ and Co2+ transporter CorC Inorganic ion transport and metabolism 152999410 Common - ABC transporter CydDC cysteine exporter (CydDC-E) family permease/ATP-binding protein CydC Shew185_0874 249 COG4987 CydC, ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 153000672 Common - Succinylglutamate desuccinylase/aspartoacylase Shew185_2148 24 COG2988 COG2988, Succinylglutamate desuccinylase Amino acid transport and metabolism 153000750 Common - diguanylate cyclase with PAS/PAC sensor Shew185_2229 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153001175 Common - gamma-glutamyltransferase Shew185_2658 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 153001359 Common - small multidrug resistance protein Shew185_2843 115 COG2076 EmrE, Membrane transporters of cations and cationic drugs Inorganic ion transport and metabolism 153000273 Common - acetate--CoA ligase Shew185_1748 212 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 153002794 Common - response regulator receiver protein Shew185_4298 9 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152998830 Common - molybdenum cofactor biosynthesis protein A Shew185_0277 202 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 153001984 Common - SlyX family protein Shew185_3475 29 COG2900 SlyX, Uncharacterized protein conserved in bacteria Function unknown 153001104 Common - acriflavin resistance protein Shew185_2587 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 153002217 Common - Nitrite reductase (cytochrome; ammonia-forming) Shew185_3711 40 COG3303 NrfA, Formate-dependent nitrite reductase, periplasmic cytochrome c552 subunit Inorganic ion transport and metabolism 152998572 Common - peptidase M24 Shew185_0017 176 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 152999764 Common - prolipoprotein diacylglyceryl transferase Shew185_1231 208 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 153001148 Common - hypothetical protein Shew185_2631 11 None None None 153000898 Nonpathogen - hypothetical protein Shew185_2378 1 None None None 153001596 Common - hypothetical protein Shew185_3083 18 None None None 152999106 Common - single-strand binding protein Shew185_0556 213 COG0629 Ssb, Single-stranded DNA-binding protein DNA replication, recombination, and repair 153001350 Common - protease-associated PA domain protein Shew185_2834 34 None None None 153002664 Common - protein of unknown function DUF1145 Shew185_4166 15 COG3776 COG3776, Predicted membrane protein Function unknown 152998837 Common - hypothetical protein Shew185_0284 1 None None None 153002797 Common - heavy metal efflux pump, CzcA family Shew185_4301 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 153001905 Common - magnesium transporter Shew185_3396 177 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 153001512 Common - inosine-5'-monophosphate dehydrogenase Shew185_2999 234 COG0516 GuaB, IMP dehydrogenase/GMP reductase Nucleotide transport and metabolism 153000854 Common - hypothetical protein Shew185_2334 2 None None None 152998764 Common - ribosomal protein L6 Shew185_0211 234 COG0097 RplF, Ribosomal protein L6P/L9E Translation, ribosomal structure and biogenesis 153000930 Common - protein of unknown function DUF938 Shew185_2411 49 None None None 153001423 Common - VacJ family lipoprotein Shew185_2907 94 COG2853 VacJ, Surface lipoprotein Cell envelope biogenesis, outer membrane 153002452 Common - Thioredoxin domain protein Shew185_3949 6 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 152999631 Common - peptidase M16 domain protein Shew185_1097 194 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 153001157 Common - hypothetical protein Shew185_2640 13 COG2515 Acd, 1-aminocyclopropane-1-carboxylate deaminase Amino acid transport and metabolism 152999056 Common - secretion protein HlyD family protein Shew185_0506 124 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 152998793 Common - Propeptide PepSY amd peptidase M4 Shew185_0240 16 COG3212 COG3212, Predicted membrane protein Function unknown 153001229 Common - Peptidase S49 domain protein Shew185_2713 189 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 152998667 Common - hypothetical protein Shew185_0114 3 None None None 153000000 Common - dTDP-4-dehydrorhamnose reductase Shew185_1468 167 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 153001538 Common - putative signal transduction protein Shew185_3025 37 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 153002161 Common - Alkaline phosphatase Shew185_3654 56 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 153001874 Common - replication P family protein Shew185_3365 8 None None None 152999407 Common - hypothetical protein Shew185_0871 8 None None None 153000116 Common - tRNA--hydroxylase Shew185_1587 40 COG4445 MiaE, Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 152998811 Common - nitrogen metabolism transcriptional regulator, NtrC, Fis Family Shew185_0258 217 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153002241 Common - Polysulphide reductase NrfD Shew185_3735 20 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 153000631 Nonpathogen - hypothetical protein Shew185_2107 1 None None None 153002816 Common - molybdopterin-guanine dinucleotide biosynthesis protein A Shew185_4320 97 COG0746 MobA, Molybdopterin-guanine dinucleotide biosynthesis protein A Coenzyme metabolism 152998734 Common - pantothenate kinase Shew185_0181 77 COG1072 CoaA, Panthothenate kinase Coenzyme metabolism 152998814 Common - Glutathione S-transferase domain Shew185_0261 77 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 152999918 Common - methyl-accepting chemotaxis sensory transducer Shew185_1386 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153000940 Common - histidinol-phosphatase Shew185_2421 219 COG0131 HisB, Imidazoleglycerol-phosphate dehydratase Amino acid transport and metabolism 152999041 Common - methylation site containing protein Shew185_0491 9 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 153000102 Common - transcriptional regulator, CdaR Shew185_1573 40 COG3835 CdaR, Sugar diacid utilization regulator Transcription / Signal transduction mechanisms 152999813 Common - hypothetical protein Shew185_1281 1 None None None 153002867 Common - ATP synthase F0, A subunit Shew185_4371 201 COG0356 AtpB, F0F1-type ATP synthase, subunit a Energy production and conversion 153001989 Common - methyl-accepting chemotaxis sensory transducer Shew185_3480 155 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153000271 Common - glutaredoxin, GrxA family Shew185_1746 43 COG0695 GrxC, Glutaredoxin and related proteins Posttranslational modification, protein turnover, chaperones 152999627 Common - sodium ion-translocating decarboxylase, beta subunit Shew185_1093 56 COG1883 OadB, Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit Energy production and conversion 153000374 Common - hypothetical protein Shew185_1849 15 None None None 153001803 Common - transcription elongation factor GreA Shew185_3294 204 COG0782 GreA, Transcription elongation factor Transcription 153002561 Common - protein of unknown function DUF1212 Shew185_4061 32 COG2966 COG2966, Uncharacterized conserved protein Function unknown 153002190 Common - short-chain dehydrogenase/reductase SDR Shew185_3683 191 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152999454 Common - NAD(P) transhydrogenase, alpha subunit Shew185_0918 166 COG3288 PntA, NAD/NADP transhydrogenase alpha subunit Energy production and conversion 153002254 Common - hypothetical protein Shew185_3748 1 COG3212 COG3212, Predicted membrane protein Function unknown 153001205 Common - TonB-dependent receptor Shew185_2688 109 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 153002674 Common - aromatic amino acid transporter Shew185_4176 35 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 153001728 Common - type IV pilus assembly PilZ Shew185_3218 20 None None None 152999309 Common - hypothetical protein Shew185_0770 11 None None None 153002025 Common - Integrase catalytic region Shew185_3516 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 153000607 Common - hypothetical protein Shew185_2083 1 None None None 153000969 Common - type IV pilus biogenesis protein PilZ Shew185_2450 32 COG3215 PilZ, Tfp pilus assembly protein PilZ Cell motility and secretion / Intracellular trafficking and secretion 152999865 Common - hypothetical protein Shew185_1333 2 None None None 153002004 Common - chromate transporter, chromate ion transporter (CHR) family Shew185_3495 114 COG2059 ChrA, Chromate transport protein ChrA Inorganic ion transport and metabolism 153000083 Common - hypothetical protein Shew185_1554 2 None None None 153002666 Common - hypothetical protein Shew185_4168 1 None None None 153001234 Common - putative transcriptional regulator Shew185_2718 155 COG1386 COG1386, Predicted transcriptional regulator containing the HTH domain Transcription 153000570 Common - exodeoxyribonuclease V, alpha subunit Shew185_2046 120 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 152998920 Common - ribonuclease PH Shew185_0369 187 COG0689 Rph, RNase PH Translation, ribosomal structure and biogenesis 152999713 Common - tryptophan halogenase Shew185_1179 17 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 153001051 Common - protein of unknown function DUF358 Shew185_2532 19 COG1901 COG1901, Uncharacterized conserved protein Function unknown 153001475 Common - flagellar basal-body rod protein FlgB Shew185_2962 70 COG1815 FlgB, Flagellar basal body protein Cell motility and secretion 153001636 Common - aspartate kinase Shew185_3123 234 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 153000913 Common - lipoprotein releasing system, transmembrane protein, LolC/E family Shew185_2393 160 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 153001774 Nonpathogen - hypothetical protein Shew185_3265 1 None None None 152999081 Common - molybdopterin oxidoreductase Shew185_0531 184 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 153000700 Common - hypothetical protein Shew185_2176 7 COG1474 CDC6, Cdc6-related protein, AAA superfamily ATPase DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones 153000290 Common - YceI family protein Shew185_1765 11 COG2353 COG2353, Uncharacterized conserved protein Function unknown 153000745 Common - hypothetical protein Shew185_2224 16 None None None 152999731 Common - major outer membrane lipoprotein, putative Shew185_1198 17 COG4238 COG4238, Murein lipoprotein Cell envelope biogenesis, outer membrane 153001826 Common - Peptidoglycan glycosyltransferase Shew185_3317 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 153002288 Common - methyl-accepting chemotaxis sensory transducer Shew185_3782 160 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152998974 Common - phosphoesterase PA-phosphatase related Shew185_0423 82 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 153000146 Common - protein of unknown function DUF81 Shew185_1617 163 COG0730 COG0730, Predicted permeases General function prediction only 152999566 Common - hypothetical protein Shew185_1032 3 None None None 153000410 Common - Porphobilinogen synthase Shew185_1885 220 COG0113 HemB, Delta-aminolevulinic acid dehydratase Coenzyme metabolism 153001876 Nonpathogen - hypothetical protein Shew185_3367 1 None None None 153002277 Common - protein of unknown function UPF0079 Shew185_3771 206 COG0802 COG0802, Predicted ATPase or kinase General function prediction only 153002347 Common - GCN5-related N-acetyltransferase Shew185_3841 85 COG2153 ElaA, Predicted acyltransferase General function prediction only 153002022 Common - Spermine synthase Shew185_3513 23 COG0421 SpeE, Spermidine synthase Amino acid transport and metabolism 153001675 Common - transcriptional regulator, LysR family Shew185_3163 129 COG0583 LysR, Transcriptional regulator Transcription 153002321 Common - hypothetical protein Shew185_3815 1 None None None 153002182 Common - glycine dehydrogenase Shew185_3675 173 COG1003 GcvP, Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain Amino acid transport and metabolism 153000453 Common - protein of unknown function DUF490 Shew185_1928 97 COG2911 COG2911, Uncharacterized protein conserved in bacteria Function unknown 153002544 Common - hypothetical protein Shew185_4044 11 COG2930 COG2930, Uncharacterized conserved protein Function unknown 153000489 Common - protein of unknown function DUF450 Shew185_1964 3 None None None 153000234 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Shew185_1709 177 COG0546 Gph, Predicted phosphatases General function prediction only 153002638 Common - transcriptional regulator, LysR family Shew185_4139 108 COG0583 LysR, Transcriptional regulator Transcription 153001354 Common - 1,4-dihydroxy-2-naphthoate octaprenyltransferase Shew185_2838 109 COG1575 MenA, 1,4-dihydroxy-2-naphthoate octaprenyltransferase Coenzyme metabolism 152999906 Common - hypothetical protein Shew185_1374 7 COG3349 COG3349, Uncharacterized conserved protein Function unknown 153000225 Nonpathogen - hypothetical protein Shew185_1700 1 None None None 153002860 Common - ATP synthase F1, epsilon subunit Shew185_4364 186 COG0355 AtpC, F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) Energy production and conversion 153002336 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Shew185_3830 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 152999078 Common - hypothetical protein Shew185_0528 1 None None None 153001646 Common - 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Shew185_3133 189 COG0245 IspF, 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase Lipid metabolism 153000619 Common - hypothetical protein Shew185_2095 3 None None None 153001257 Nonpathogen - hypothetical protein Shew185_2741 2 None None None 153000308 Common - peptidase M48 Ste24p Shew185_1783 125 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 153002122 Common - Glutamyl-tRNA reductase Shew185_3615 182 COG0373 HemA, Glutamyl-tRNA reductase Coenzyme metabolism 153000606 Common - glycoside hydrolase family 24 Shew185_2082 21 COG3772 COG3772, Phage-related lysozyme (muraminidase) General function prediction only 152999052 Common - hypothetical protein Shew185_0502 57 COG3164 COG3164, Predicted membrane protein Function unknown 153002694 Common - two component transcriptional regulator, winged helix family Shew185_4196 218 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152998712 Common - type II secretion system protein N Shew185_0159 7 COG4571 OmpT, Outer membrane protease Cell envelope biogenesis, outer membrane 153000804 Common - Radical SAM domain protein Shew185_2284 75 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 153000697 Common - hypothetical protein Shew185_2173 1 None None None 153001402 Common - lipoprotein Shew185_2886 20 COG3015 CutF, Uncharacterized lipoprotein NlpE involved in copper resistance Cell envelope biogenesis, outer membrane / Inorganic ion transport and metabolism 152999871 Common - FAD linked oxidase domain protein Shew185_1339 199 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 153000676 Common - quinolinate synthetase complex, A subunit Shew185_2152 196 COG0379 NadA, Quinolinate synthase Coenzyme metabolism 153000333 Common - hypothetical protein Shew185_1808 9 COG4984 COG4984, Predicted membrane protein Function unknown 152999878 Common - MotA/TolQ/ExbB proton channel Shew185_1346 88 COG1291 MotA, Flagellar motor component Cell motility and secretion 153000344 Common - heat shock protein DnaJ domain protein Shew185_1819 227 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 152998591 Common - protein of unknown function DUF1488 Shew185_0036 5 None None None 152999277 Nonpathogen - hypothetical protein Shew185_0738 1 None None None 153001602 Common - transcriptional regulator, TetR family Shew185_3089 79 COG1309 AcrR, Transcriptional regulator Transcription 153002456 Common - transcription termination factor Rho Shew185_3953 200 COG1158 Rho, Transcription termination factor Transcription 153002531 Common - Endoribonuclease L-PSP Shew185_4031 133 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 153001609 Common - metal dependent phosphohydrolase Shew185_3096 123 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 153001739 Common - deoxyribose-phosphate aldolase Shew185_3230 138 COG0274 DeoC, Deoxyribose-phosphate aldolase Nucleotide transport and metabolism 153000803 Common - hypothetical protein Shew185_2283 14 None None None 153002513 Common - ketol-acid reductoisomerase Shew185_4010 210 COG0059 IlvC, Ketol-acid reductoisomerase Amino acid transport and metabolism / Coenzyme metabolism 152999616 Common - pseudouridine synthase Shew185_1082 170 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 153001258 Common - uncharacterized conserved coiled coil protein Shew185_2742 21 None None None 153000717 Common - protein of unknown function DUF262 Shew185_2195 50 COG1479 COG1479, Uncharacterized conserved protein Function unknown 153000204 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Shew185_1677 30 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 152999581 Common - 4-hydroxythreonine-4-phosphate dehydrogenase Shew185_1047 159 COG1995 PdxA, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 153000393 Common - hypothetical protein Shew185_1868 8 None None None 153002808 Common - hypothetical protein Shew185_4312 4 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 153000797 Common - protein of unknown function DUF1049 Shew185_2277 21 COG3771 COG3771, Predicted membrane protein Function unknown 152999419 Common - protein of unknown function DUF47 Shew185_0883 37 COG1392 COG1392, Phosphate transport regulator (distant homolog of PhoU) Inorganic ion transport and metabolism 153000099 Common - Glycerate kinase Shew185_1570 81 COG1929 COG1929, Glycerate kinase Carbohydrate transport and metabolism 153001730 Common - type IV pilus assembly PilZ Shew185_3221 7 None None None 153000481 Nonpathogen - hypothetical protein Shew185_1956 1 None None None 153002856 Common - glucosamine--fructose-6-phosphate aminotransferase, isomerizing Shew185_4360 238 COG0449 GlmS, Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains Cell envelope biogenesis, outer membrane 153000976 Common - ATP-binding protein, Mrp/Nbp35 family Shew185_2457 233 COG0489 Mrp, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 152999347 Common - glutathione synthetase Shew185_0808 125 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 153001420 Common - transcriptional acivator RfaH Shew185_2904 94 COG0250 NusG, Transcription antiterminator Transcription 152999817 Common - two component transcriptional regulator, LuxR family Shew185_1285 221 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 153000053 Common - hypothetical protein Shew185_1523 11 COG1462 CsgG, Uncharacterized protein involved in formation of curli polymers Cell envelope biogenesis, outer membrane 153000772 Common - CoA-binding domain protein Shew185_2252 151 COG1042 COG1042, Acyl-CoA synthetase (NDP forming) Energy production and conversion 153001624 Common - Domain of unknown function DUF1791 Shew185_3111 11 COG1416 COG1416, Uncharacterized conserved protein Function unknown 153001497 Common - hypothetical protein Shew185_2984 19 None None None 153000044 Common - ABC transporter related Shew185_1514 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 153001090 Nonpathogen - hypothetical protein Shew185_2573 1 None None None 153002069 Common - NADH:ubiquinone oxidoreductase, subunit D Shew185_3561 76 COG1347 NqrD, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD Energy production and conversion 153000110 Common - outer membrane protein, putative Shew185_1581 9 None None None 152999603 Common - protein of unknown function DUF1289 Shew185_1069 23 COG3313 COG3313, Predicted Fe-S protein General function prediction only 153002212 Common - Tetratricopeptide TPR_2 repeat protein Shew185_3705 9 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153001719 Common - CBS domain containing protein Shew185_3209 137 COG0517 COG0517, FOG: CBS domain General function prediction only 152999824 Common - transcriptional regulator, TetR family Shew185_1292 92 COG1309 AcrR, Transcriptional regulator Transcription 153000289 Common - protein of unknown function DUF188 Shew185_1764 98 COG1671 COG1671, Uncharacterized protein conserved in bacteria Function unknown 153000879 Common - transposase IS200-family protein Shew185_2359 73 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 153001443 Common - flagellar biosynthesis protein FliO Shew185_2927 7 COG3190 FliO, Flagellar biogenesis protein Cell motility and secretion 153002503 Common - sodium:neurotransmitter symporter Shew185_4000 88 COG0733 COG0733, Na+-dependent transporters of the SNF family General function prediction only 153002361 Common - acetyl-CoA carboxylase, biotin carboxyl carrier protein Shew185_3855 187 COG0511 AccB, Biotin carboxyl carrier protein Lipid metabolism 153001288 Common - phosphohistidine phosphatase, SixA Shew185_2772 43 COG2062 SixA, Phosphohistidine phosphatase SixA Signal transduction mechanisms 152999671 Common - SapC family protein Shew185_1137 26 None None None 152998768 Common - ribosomal protein L15 Shew185_0215 216 COG0200 RplO, Ribosomal protein L15 Translation, ribosomal structure and biogenesis 152999048 Common - rod shape-determining protein MreC Shew185_0498 123 COG1792 MreC, Cell shape-determining protein Cell envelope biogenesis, outer membrane 153002152 Nonpathogen - hypothetical protein Shew185_3645 5 None None None 153002292 Common - protein kinase Shew185_3786 83 COG0515 SPS1, Serine/threonine protein kinase General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair 152998692 Common - glycosyl transferase family 51 Shew185_0139 58 COG5009 MrcA, Membrane carboxypeptidase/penicillin-binding protein Cell envelope biogenesis, outer membrane 153001698 Common - transcriptional regulator, LysR family Shew185_3186 183 COG0583 LysR, Transcriptional regulator Transcription 153000950 Common - protein of unknown function DUF1379 Shew185_2431 17 None None None 153001490 Common - N-acylneuraminate-9-phosphate synthase Shew185_2977 78 COG2089 SpsE, Sialic acid synthase Cell envelope biogenesis, outer membrane 153000300 Common - Superoxide dismutase Shew185_1775 208 COG0605 SodA, Superoxide dismutase Inorganic ion transport and metabolism 153002047 Common - Phosphoglycerate kinase Shew185_3538 247 COG0126 Pgk, 3-phosphoglycerate kinase Carbohydrate transport and metabolism 153001619 Common - Aldehyde ferredoxin oxidoreductase Shew185_3106 56 COG2414 COG2414, Aldehyde:ferredoxin oxidoreductase Energy production and conversion 153001900 Common - putative lipoprotein Shew185_3391 8 None None None 152999894 Common - putative exonuclease RdgC Shew185_1362 53 COG2974 RdgC, DNA recombination-dependent growth factor C DNA replication, recombination, and repair 153001464 Common - flagellin domain protein Shew185_2951 125 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 152999772 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Shew185_1239 174 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153000251 Common - asparagine synthase (glutamine-hydrolyzing) Shew185_1726 161 COG0367 AsnB, Asparagine synthase (glutamine-hydrolyzing) Amino acid transport and metabolism 153001375 Common - restriction endonuclease Shew185_2859 33 COG1787 COG1787, Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes Defense mechanisms 152999611 Common - Protein of unknown function DUF1971 Shew185_1077 23 COG3615 TehB, Uncharacterized protein/domain, possibly involved in tellurite resistance Inorganic ion transport and metabolism 152999038 Common - type II secretion system protein Shew185_0488 148 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 153000769 Common - response regulator receiver protein Shew185_2249 155 COG2208 RsbU, Serine phosphatase RsbU, regulator of sigma subunit Signal transduction mechanisms / Transcription 152999741 Common - iron-sulfur cluster assembly accessory protein Shew185_1208 166 COG0316 IscA, Uncharacterized conserved protein Function unknown 153002614 Nonpathogen - hypothetical protein Shew185_4115 3 None None None 153001212 Common - hypothetical protein Shew185_2695 4 None None None 153002817 Common - molybdopterin-guanine dinucleotide biosynthesis protein B Shew185_4321 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 153001853 Common - hypothetical protein Shew185_3344 7 None None None 153002054 Common - acetyltransferase, GNAT family Shew185_3545 4 None None None 153000766 Common - putative CheW protein Shew185_2246 131 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153002280 Common - Exonuclease RNase T and DNA polymerase III Shew185_3774 88 COG1949 Orn, Oligoribonuclease (3'->5' exoribonuclease) RNA processing and modification 152999388 Common - GCN5-related N-acetyltransferase Shew185_0852 14 COG0456 RimI, Acetyltransferases General function prediction only 153001749 Common - CRISPR-associated helicase Cas3 family Shew185_3240 17 COG1203 COG1203, Predicted helicases General function prediction only 152999514 Common - cobalbumin biosynthesis protein Shew185_0979 129 COG2087 CobU, Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase Coenzyme metabolism 152998627 Common - regulatory protein GntR HTH Shew185_0072 97 COG1725 COG1725, Predicted transcriptional regulators Transcription 153001432 Common - CheA signal transduction histidine kinase Shew185_2916 153 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 152999994 Common - diguanylate cyclase Shew185_1462 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153002134 Common - hypothetical protein Shew185_3627 7 None None None 153002262 Common - putative signal transduction protein Shew185_3756 4 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 153001457 Common - flagellar protein FliS Shew185_2941 69 COG1516 FliS, Flagellin-specific chaperone FliS Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 153002096 Common - ABC transporter related Shew185_3589 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 152999961 Common - hypothetical protein Shew185_1429 5 None None None 152998828 Common - methyl-accepting chemotaxis sensory transducer Shew185_0275 151 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152999761 Common - NUDIX hydrolase Shew185_1228 114 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 152999156 Common - porin Gram-negative type Shew185_0613 19 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 152999259 Common - TonB-dependent siderophore receptor Shew185_0720 116 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 153002399 Common - hypothetical protein Shew185_3893 2 None None None 152999230 Common - KpsF/GutQ family protein Shew185_0691 171 COG0794 GutQ, Predicted sugar phosphate isomerase involved in capsule formation Cell envelope biogenesis, outer membrane 153001524 Common - transcriptional regulator, LysR family Shew185_3011 178 COG0583 LysR, Transcriptional regulator Transcription 152999241 Common - ribosomal protein L13 Shew185_0702 235 COG0102 RplM, Ribosomal protein L13 Translation, ribosomal structure and biogenesis 152999429 Common - (Glutamate--ammonia-ligase) adenylyltransferase Shew185_0893 119 COG1391 GlnE, Glutamine synthetase adenylyltransferase Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms 153002645 Common - protein of unknown function DUF1332 Shew185_4146 37 COG4103 COG4103, Uncharacterized protein conserved in bacteria Function unknown 152999924 Common - ferric uptake regulator, Fur family Shew185_1392 198 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 152998702 Common - general secretion pathway protein D Shew185_0149 141 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 153002430 Common - aconitate hydratase 2 Shew185_3925 218 COG1049 AcnB, Aconitase B Energy production and conversion 152999478 Common - heat shock protein DnaJ domain protein Shew185_0942 21 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 153001088 Common - hypothetical protein Shew185_2571 15 None None None 152999664 Common - hypothetical protein Shew185_1130 1 None None None 153002829 Common - glycosyl transferase group 1 Shew185_4333 18 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152999426 Common - Spermidine synthase Shew185_0890 99 COG4262 COG4262, Predicted spermidine synthase with an N-terminal membrane domain General function prediction only 152999215 Nonpathogen - hypothetical protein Shew185_0675 1 None None None 153001691 Common - hypothetical protein Shew185_3179 20 None None None 152999786 Common - signal recognition particle protein Shew185_1253 247 COG0541 Ffh, Signal recognition particle GTPase Intracellular trafficking and secretion 152999560 Common - Cytochrome c oxidase cbb3 type accessory protein FixG Shew185_1026 81 COG0348 NapH, Polyferredoxin Energy production and conversion 153002481 Common - porphobilinogen deaminase Shew185_3978 222 COG0181 HemC, Porphobilinogen deaminase Coenzyme metabolism 153001183 Common - hypothetical protein Shew185_2666 9 COG3110 COG3110, Uncharacterized protein conserved in bacteria Function unknown 153002426 Common - uroporphyrinogen decarboxylase Shew185_3920 182 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 152999179 Common - Protein-disulfide reductase Shew185_0636 170 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 153002435 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Shew185_3930 193 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 153000534 Common - intracellular proteinase inhibitor domain protein Shew185_2009 2 None None None 153001883 Common - hypothetical protein Shew185_3374 2 None None None 153002354 Common - efflux transporter, RND family, MFP subunit Shew185_3848 107 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 153000151 Common - TonB-dependent receptor Shew185_1623 115 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 152998748 Common - ribosomal protein S10 Shew185_0195 247 COG0051 RpsJ, Ribosomal protein S10 Translation, ribosomal structure and biogenesis 153001581 Common - Deoxyribodipyrimidine photo-lyase Shew185_3068 135 COG0415 PhrB, Deoxyribodipyrimidine photolyase DNA replication, recombination, and repair 153001019 Common - hypothetical protein Shew185_2500 4 COG4639 COG4639, Predicted kinase General function prediction only 152999460 Common - hypothetical protein Shew185_0924 6 None None None 153000446 Common - integral membrane sensor signal transduction histidine kinase Shew185_1921 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152999857 Common - Starch synthase catalytic domain protein Shew185_1325 141 COG0297 GlgA, Glycogen synthase Carbohydrate transport and metabolism 153001557 Common - hypothetical protein Shew185_3044 13 None None None 152998878 Common - 3-oxoacyl-(acyl-carrier-protein) reductase, putative Shew185_0326 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153000297 Common - SpoVR family protein Shew185_1772 71 COG2719 SpoVR, Uncharacterized conserved protein Function unknown 153002654 Common - transposase IS4 family protein Shew185_4156 32 COG5433 COG5433, Transposase DNA replication, recombination, and repair 152999122 Common - hypothetical protein Shew185_0575 3 None None None 153001271 Common - amidophosphoribosyltransferase Shew185_2755 240 COG0034 PurF, Glutamine phosphoribosylpyrophosphate amidotransferase Nucleotide transport and metabolism 153001542 Common - Redoxin domain protein Shew185_3029 126 COG2077 Tpx, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 153000018 Common - short-chain dehydrogenase/reductase SDR Shew185_1486 129 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 152998800 Common - short-chain dehydrogenase/reductase SDR Shew185_0247 236 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153001785 Common - diguanylate cyclase/phosphodiesterase Shew185_3276 177 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152998865 Common - hypothetical protein Shew185_0313 6 None None None 153002729 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Shew185_4231 97 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152998707 Common - general secretion pathway protein I Shew185_0154 40 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 152999287 Common - Exonuclease RNase T and DNA polymerase III Shew185_0748 88 COG1949 Orn, Oligoribonuclease (3'->5' exoribonuclease) RNA processing and modification 153002237 Common - hypothetical protein Shew185_3731 102 COG1196 Smc, Chromosome segregation ATPases Cell division and chromosome partitioning 153000260 Common - ribonuclease T Shew185_1735 66 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 152998918 Common - HipA-like protein Shew185_0366 6 None None None 153001450 Common - flagellar assembly protein FliH Shew185_2934 67 COG1317 FliH, Flagellar biosynthesis/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 153000361 Common - transcriptional regulator, LysR family Shew185_1836 181 COG0583 LysR, Transcriptional regulator Transcription 153001998 Common - catalase/peroxidase HPI Shew185_3489 98 COG0376 KatG, Catalase (peroxidase I) Inorganic ion transport and metabolism 153001921 Common - protein of unknown function DUF6 transmembrane Shew185_3412 63 None None None 153000267 Common - Tol-Pal system beta propeller repeat TolB Shew185_1742 155 COG0823 TolB, Periplasmic component of the Tol biopolymer transport system Intracellular trafficking and secretion 152999729 Common - putative undecaprenol kinase Shew185_1196 200 COG1968 BacA, Uncharacterized bacitracin resistance protein Defense mechanisms 153002133 Common - hypothetical protein Shew185_3626 4 COG2357 COG2357, Uncharacterized protein conserved in bacteria Function unknown 153002126 Common - methyl-accepting chemotaxis sensory transducer Shew185_3619 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152999129 Nonpathogen - hypothetical protein Shew185_0585 1 None None None 152999396 Common - transcriptional regulator, HxlR family Shew185_0860 104 COG1733 COG1733, Predicted transcriptional regulators Transcription 152998634 Common - hypothetical protein Shew185_0079 16 COG2388 COG2388, Predicted acetyltransferase General function prediction only 152998589 Common - globin Shew185_0034 66 COG2346 COG2346, Truncated hemoglobins General function prediction only 153001658 Common - RNA methyltransferase, TrmA family Shew185_3145 200 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 152999657 Common - peptidylprolyl isomerase FKBP-type Shew185_1123 119 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 152999949 Common - Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ Shew185_1417 209 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 153002146 Common - putative iron-sulfur cluster binding protein Shew185_3639 132 COG1600 COG1600, Uncharacterized Fe-S protein Energy production and conversion 153002722 Common - DSBA oxidoreductase Shew185_4224 78 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 152999438 Common - putative tricarboxylic transport membrane protein Shew185_0902 13 None None None 153000551 Common - Substrate-binding region of ABC-type glycine betaine transport system Shew185_2026 39 COG2113 ProX, ABC-type proline/glycine betaine transport systems, periplasmic components Amino acid transport and metabolism 153000031 Common - copper-translocating P-type ATPase Shew185_1499 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 152999132 Common - Ig domain protein group 1 domain protein Shew185_0588 3 None None None 153000939 Common - histidinol-phosphate aminotransferase Shew185_2420 229 COG0079 HisC, Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase Amino acid transport and metabolism 153001937 Common - methyl-accepting chemotaxis sensory transducer Shew185_3428 146 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153000874 Common - succinyl-diaminopimelate desuccinylase Shew185_2354 213 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 153001072 Common - phage integrase family protein Shew185_2555 31 COG0582 XerC, Integrase DNA replication, recombination, and repair 152998556 Common - chromosomal replication initiator protein DnaA Shew185_0001 213 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 152998744 Common - ribosomal protein S12 Shew185_0191 236 COG0048 RpsL, Ribosomal protein S12 Translation, ribosomal structure and biogenesis 153000490 Common - putative phage repressor Shew185_1965 50 COG2932 COG2932, Predicted transcriptional regulator Transcription 153000996 Common - hypothetical protein Shew185_2477 1 None None None 153002493 Common - ATP-dependent DNA helicase Rep Shew185_3990 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 153001124 Common - hypothetical protein Shew185_2607 6 COG5563 COG5563, Predicted integral membrane proteins containing uncharacterized repeats Function unknown 153001102 Common - Thioredoxin domain protein Shew185_2585 117 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 153001651 Common - MazG family protein Shew185_3138 157 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 152999720 Common - methyl-accepting chemotaxis sensory transducer Shew185_1187 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152998852 Common - Domain of unknown function DUF1864 Shew185_0299 4 None None None 153002129 Common - hypothetical protein Shew185_3622 23 COG3595 COG3595, Uncharacterized conserved protein Function unknown 153000709 Nonpathogen - hypothetical protein Shew185_2185 2 None None None 153002406 Nonpathogen - hypothetical protein Shew185_3900 1 None None None 152999280 Common - hypothetical protein Shew185_0741 8 COG4197 COG4197, Uncharacterized protein conserved in bacteria, prophage-related Function unknown 153001079 Common - hypothetical protein Shew185_2562 6 None None None 153000402 Common - Amidohydrolase 3 Shew185_1877 62 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 152999473 Common - putative lipoprotein Shew185_0937 9 COG3487 IrpA, Uncharacterized iron-regulated protein Inorganic ion transport and metabolism 152999847 Common - choline dehydrogenase Shew185_1315 92 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 153001383 Common - histone family protein nucleoid-structuring protein H-NS Shew185_2867 22 COG2916 Hns, DNA-binding protein H-NS General function prediction only 153001966 Common - ApbE family protein, putative Shew185_3457 23 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 153001081 Common - hypothetical protein Shew185_2564 7 None None None 152998786 Common - cytochrome C biogenesis protein Shew185_0233 92 COG3088 CcmH, Uncharacterized protein involved in biosynthesis of c-type cytochromes Posttranslational modification, protein turnover, chaperones 152999292 Common - phage terminase GpA Shew185_0753 37 COG5525 COG5525, Bacteriophage tail assembly protein General function prediction only 153000198 Common - lipoprotein, putative Shew185_1671 4 None None None 152999217 Common - transposase IS3/IS911 family protein Shew185_0677 2 None None None 152999855 Common - glycogen/starch/alpha-glucan phosphorylase Shew185_1323 135 COG0058 GlgP, Glucan phosphorylase Carbohydrate transport and metabolism 153001455 Common - PAS/PAC sensor signal transduction histidine kinase Shew185_2939 215 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 153002595 Common - Phosphoenolpyruvate carboxylase Shew185_4096 116 COG2352 Ppc, Phosphoenolpyruvate carboxylase Energy production and conversion 152998670 Common - MscS Mechanosensitive ion channel Shew185_0117 95 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 153001687 Common - protein of unknown function DUF88 Shew185_3175 31 COG1432 COG1432, Uncharacterized conserved protein Function unknown 152998775 Common - ribosomal protein L17 Shew185_0222 216 COG0203 RplQ, Ribosomal protein L17 Translation, ribosomal structure and biogenesis 153002820 Common - formamidopyrimidine-DNA glycosylase Shew185_4324 178 COG0266 Nei, Formamidopyrimidine-DNA glycosylase DNA replication, recombination, and repair 153000920 Common - hypothetical protein Shew185_2400 3 None None None 153002520 Common - phospholipid/glycerol acyltransferase Shew185_4018 30 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 153001564 Common - protein of unknown function DUF469 Shew185_3051 21 COG3171 COG3171, Uncharacterized protein conserved in bacteria Function unknown 153002529 Common - branched-chain amino acid aminotransferase Shew185_4027 190 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 153001665 Common - phosphatidylglycerophosphatase A Shew185_3152 104 COG1267 PgpA, Phosphatidylglycerophosphatase A and related proteins Lipid metabolism 153001239 Common - glutamine amidotransferase of anthranilate synthase Shew185_2723 234 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 152999222 Common - uncharacterised P-loop ATPase protein UPF0042 Shew185_0683 140 COG1660 COG1660, Predicted P-loop-containing kinase General function prediction only 152999553 Common - MotA/TolQ/ExbB proton channel Shew185_1019 11 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 153001918 Common - hypothetical protein Shew185_3409 1 None None None 153001623 Common - protein of unknown function DUF1449 Shew185_3110 14 None None None 152999110 Common - hypothetical protein Shew185_0560 14 None None None 153000517 Nonpathogen - hypothetical protein Shew185_1992 2 None None None 152999209 Common - hypothetical protein Shew185_0669 6 None None None 153000326 Common - GCN5-related N-acetyltransferase Shew185_1801 88 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 152999024 Common - arginyl-tRNA synthetase Shew185_0474 249 COG0018 ArgS, Arginyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153000927 Common - Alcohol dehydrogenase class III/S-(hydroxymethyl)glutathione dehydrogenase Shew185_2408 192 COG1062 AdhC, Zn-dependent alcohol dehydrogenases, class III Energy production and conversion 153002245 Common - hypothetical protein Shew185_3739 1 None None None 153000436 Common - hypothetical protein Shew185_1911 5 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 152999195 Common - putative aminopeptidase precursor Shew185_0655 37 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 152999200 Common - transcriptional regulator, PadR-like family Shew185_0660 57 COG1695 COG1695, Predicted transcriptional regulators Transcription 152999101 Common - hypothetical protein Shew185_0551 1 None None None 152999058 Common - ABC-2 type transporter Shew185_0508 84 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 153000357 Common - peptidase M28 Shew185_1832 51 COG2234 Iap, Predicted aminopeptidases General function prediction only 153000385 Nonpathogen - hypothetical protein Shew185_1860 1 None None None 153002386 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Shew185_3880 152 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 152999978 Common - translation elongation factor Ts Shew185_1446 216 COG0264 Tsf, Translation elongation factor Ts Translation, ribosomal structure and biogenesis 152999839 Common - malate synthase A Shew185_1307 77 COG2225 AceB, Malate synthase Energy production and conversion 153002177 Common - short-chain dehydrogenase/reductase SDR Shew185_3670 45 COG4221 COG4221, Short-chain alcohol dehydrogenase of unknown specificity General function prediction only 153002408 Common - TRAP transporter, 4TM/12TM fusion protein Shew185_3902 134 COG4666 COG4666, TRAP-type uncharacterized transport system, fused permease components General function prediction only 152998791 Common - integral membrane sensor signal transduction histidine kinase Shew185_0238 154 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152999325 Common - DNA topoisomerase IV, B subunit Shew185_0786 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 153002030 Common - GCN5-related N-acetyltransferase Shew185_3521 35 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 153000685 Common - UspA domain protein Shew185_2161 78 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 152999175 Common - hypothetical protein Shew185_0632 1 None None None 153001930 Common - peptidase M17 leucyl aminopeptidase domain protein Shew185_3421 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 153002814 Common - binding-protein-dependent transport systems inner membrane component Shew185_4318 182 COG4662 TupA, ABC-type tungstate transport system, periplasmic component Coenzyme metabolism 152998624 Common - transport protein, putative Shew185_0069 26 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 152999263 Common - GCN5-related N-acetyltransferase Shew185_0724 43 COG3153 COG3153, Predicted acetyltransferase General function prediction only 153001247 Common - hypothetical protein Shew185_2731 29 None None None 153002703 Common - multi-sensor hybrid histidine kinase Shew185_4205 225 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153002771 Common - transposase IS3/IS911 family protein Shew185_4274 147 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 153001835 Common - hypothetical protein Shew185_3326 1 None None None 152998998 Common - hypothetical protein Shew185_0448 2 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 153000400 Nonpathogen - hypothetical protein Shew185_1875 1 None None None 152999849 Common - hypothetical protein Shew185_1317 35 None None None 153000240 Common - malonyl CoA-acyl carrier protein transacylase Shew185_1715 209 COG0331 FabD, (acyl-carrier-protein) S-malonyltransferase Lipid metabolism 152999945 Nonpathogen - protein of unknown function DUF1328 Shew185_1413 1 COG5487 COG5487, Small integral membrane protein Function unknown 153002825 Common - NAD-dependent epimerase/dehydratase Shew185_4329 232 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153001855 Common - ABC transporter related Shew185_3346 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 153002107 Common - major facilitator superfamily MFS_1 Shew185_3600 108 None None None 153002830 Common - CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase Shew185_4334 7 COG1887 TagB, Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC Cell envelope biogenesis, outer membrane 153002185 Common - Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family Shew185_3678 131 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 152998845 Nonpathogen - hypothetical protein Shew185_0292 1 None None None 152998687 Common - 3,4-dihydroxy-2-butanone 4-phosphate synthase Shew185_0134 229 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 153002305 Common - hypothetical protein Shew185_3799 15 None None None 152998607 Common - integral membrane sensor signal transduction histidine kinase Shew185_0052 221 COG2205 KdpD, Osmosensitive K+ channel histidine kinase Signal transduction mechanisms 153001909 Common - carbamoyl-phosphate synthase, large subunit Shew185_3400 236 COG0458 CarB, Carbamoylphosphate synthase large subunit (split gene in MJ) Amino acid transport and metabolism / Nucleotide transport and metabolism 153000135 Common - phage shock protein A, PspA Shew185_1606 81 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 153000863 Common - Cupin 4 family protein Shew185_2343 60 COG2850 COG2850, Uncharacterized conserved protein Function unknown 153000573 Common - transglutaminase domain protein Shew185_2049 112 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 153001961 Common - GreA/GreB family elongation factor Shew185_3452 3 COG0782 GreA, Transcription elongation factor Transcription 153000645 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Shew185_2121 175 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 153000945 Common - aromatic amino acid transporter Shew185_2426 33 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 153000188 Common - RepA domain protein Shew185_1661 3 None None None 153002616 Common - Bile acid:sodium symporter Shew185_4117 99 COG0385 COG0385, Predicted Na+-dependent transporter General function prediction only 153001972 Nonpathogen - hypothetical protein Shew185_3463 1 None None None 152999354 Common - Carbamoyl-phosphate synthase L chain ATP-binding Shew185_0815 231 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 153002298 Common - Enoyl-CoA hydratase/isomerase Shew185_3792 170 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 152999340 Common - ABC transporter related Shew185_0801 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 152999530 Common - efflux transporter, RND family, MFP subunit Shew185_0996 146 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 152998779 Common - heme exporter protein CcmC Shew185_0226 113 COG0755 CcmC, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 153001902 Common - hypothetical protein Shew185_3393 31 None None None 153000755 Common - helix-turn-helix- domain containing protein AraC type Shew185_2234 65 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 152999805 Common - homoserine kinase Shew185_1272 107 COG0083 ThrB, Homoserine kinase Amino acid transport and metabolism 153002685 Common - cytochrome oxidase assembly Shew185_4187 36 COG1612 CtaA, Uncharacterized protein required for cytochrome oxidase assembly Posttranslational modification, protein turnover, chaperones 153002766 Common - putative prophage repressor Shew185_4269 71 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 152999913 Common - TonB-dependent heme/hemoglobin receptor family protein Shew185_1381 79 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 153002558 Common - periplasmic binding protein/LacI transcriptional regulator Shew185_4058 126 COG1609 PurR, Transcriptional regulators Transcription 153002505 Nonpathogen - hypothetical protein Shew185_4002 1 None None None 152999620 Common - pseudouridine synthase, RluA family Shew185_1086 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 153002059 Common - hypothetical protein Shew185_3550 1 None None None 153000245 Common - thioesterase superfamily protein Shew185_1720 134 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 153000983 Common - translation initiation factor IF-1 Shew185_2464 214 COG0361 InfA, Translation initiation factor 1 (IF-1) Translation, ribosomal structure and biogenesis 153001318 Common - Rhodanese domain protein Shew185_2802 116 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 153002740 Common - diguanylate cyclase/phosphodiesterase Shew185_4242 162 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 153001896 Common - 3'-5' exonuclease Shew185_3387 25 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 152998807 Common - two component transcriptional regulator, winged helix family Shew185_0254 220 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152998641 Common - hypothetical protein Shew185_0086 9 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 153000063 Common - binding-protein-dependent transport systems inner membrane component Shew185_1533 220 COG4590 COG4590, ABC-type uncharacterized transport system, permease component General function prediction only 153000148 Common - DNA polymerase B region Shew185_1619 64 COG0417 PolB, DNA polymerase elongation subunit (family B) DNA replication, recombination, and repair 153000366 Common - phage integrase family protein Shew185_1841 16 None None None 152999701 Common - spermidine/putrescine ABC transporter ATPase subunit Shew185_1167 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 153000522 Common - hypothetical protein Shew185_1997 2 None None None 152999512 Common - Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Shew185_0977 118 COG2038 CobT, NaMN:DMB phosphoribosyltransferase Coenzyme metabolism 152999069 Common - diguanylate phosphodiesterase Shew185_0519 162 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152998736 Common - preprotein translocase, SecE subunit Shew185_0183 67 COG0690 SecE, Preprotein translocase subunit SecE Intracellular trafficking and secretion 153002291 Common - hypothetical protein Shew185_3785 1 None None None 153001772 Nonpathogen - hypothetical protein Shew185_3263 1 None None None 152998679 Common - flagellar basal body-associated protein FliL Shew185_0126 16 COG1580 FliL, Flagellar basal body-associated protein Cell motility and secretion 153000965 Common - Mammalian cell entry related domain protein Shew185_2446 56 COG3008 PqiB, Paraquat-inducible protein B General function prediction only 153001571 Common - hypothetical protein Shew185_3058 2 None None None 152998610 Common - two component transcriptional regulator, LytTR family Shew185_0055 159 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 153001588 Common - hypothetical protein Shew185_3075 12 None None None 153000190 Common - type IV pilus assembly PilZ Shew185_1663 2 None None None 152999519 Common - aldehyde dehydrogenase Shew185_0984 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 152999840 Common - isocitrate lyase Shew185_1308 128 COG2224 AceA, Isocitrate lyase Energy production and conversion 153002229 Nonpathogen - hypothetical protein Shew185_3723 1 None None None 153001322 Common - preprotein translocase, YajC subunit Shew185_2806 175 COG1862 YajC, Preprotein translocase subunit YajC Intracellular trafficking and secretion 153001335 Common - methylated-DNA--protein-cysteine methyltransferase Shew185_2819 176 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 153001598 Common - transcriptional regulator, LysR family Shew185_3085 190 COG0583 LysR, Transcriptional regulator Transcription 153000476 Common - phage integrase family protein Shew185_1951 74 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 153002549 Common - protein of unknown function DUF1232 Shew185_4049 40 COG3339 COG3339, Uncharacterized conserved protein Function unknown 153001263 Common - (2Fe-2S)-binding domain protein Shew185_2747 122 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 153001306 Common - sodium/proline symporter Shew185_2790 187 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 152999954 Common - lipoprotein, putative Shew185_1422 1 None None None 153002805 Common - ABC transporter related Shew185_4309 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 152999984 Common - putative membrane-associated zinc metalloprotease Shew185_1452 211 COG0750 COG0750, Predicted membrane-associated Zn-dependent proteases 1 Cell envelope biogenesis, outer membrane 153000265 Common - Biopolymer transport TolR Shew185_1740 139 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 153000424 Common - methyl-accepting chemotaxis sensory transducer Shew185_1899 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153001042 Common - hypothetical protein Shew185_2523 7 None None None 153002779 Common - sodium/proline symporter Shew185_4283 152 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 152999117 Nonpathogen - hypothetical protein Shew185_0570 1 None None None 153001413 Common - NAD-dependent epimerase/dehydratase Shew185_2897 16 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153002364 Common - hypothetical protein Shew185_3858 1 None None None 152999239 Common - protease Do Shew185_0700 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 153000677 Common - glyceraldehyde-3-phosphate dehydrogenase, type I Shew185_2153 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 152998905 Common - Guanylate kinase Shew185_0353 214 COG0194 Gmk, Guanylate kinase Nucleotide transport and metabolism 153001328 Common - hypothetical protein Shew185_2812 2 None None None 153002790 Common - transcriptional regulator, XRE family Shew185_4294 10 COG1396 HipB, Predicted transcriptional regulators Transcription 153002767 Nonpathogen - hypothetical protein Shew185_4270 3 None None None 152998964 Common - hypothetical protein Shew185_0413 4 None None None 153000846 Common - DTW domain containing protein Shew185_2326 27 COG3148 COG3148, Uncharacterized conserved protein Function unknown 152999830 Common - SsrA-binding protein Shew185_1298 216 COG0691 SmpB, tmRNA-binding protein Posttranslational modification, protein turnover, chaperones 153002784 Common - efflux transporter, RND family, MFP subunit Shew185_4288 168 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153002837 Common - L-threonine 3-dehydrogenase Shew185_4341 214 COG1063 Tdh, Threonine dehydrogenase and related Zn-dependent dehydrogenases Amino acid transport and metabolism / General function prediction only 153000218 Nonpathogen - hypothetical protein Shew185_1692 1 None None None 153000205 Common - protein of unknown function DUF1289 Shew185_1678 15 COG3313 COG3313, Predicted Fe-S protein General function prediction only 153000974 Common - deoxycytidine triphosphate deaminase Shew185_2455 152 COG0717 Dcd, Deoxycytidine deaminase Nucleotide transport and metabolism 153002751 Common - conserved hypothetical 3-methyladenine DNA glycosylase Shew185_4253 56 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 152999963 Common - GCN5-related N-acetyltransferase Shew185_1431 7 None None None 153001752 Common - response regulator receiver protein Shew185_3243 6 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153001299 Common - protein of unknown function DUF58 Shew185_2783 101 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 153000423 Common - protein of unknown function UPF0153 Shew185_1898 74 COG2983 COG2983, Uncharacterized conserved protein Function unknown 153000090 Common - AzlC family protein Shew185_1561 107 COG1296 AzlC, Predicted branched-chain amino acid permease (azaleucine resistance) Amino acid transport and metabolism 153000595 Common - hypothetical protein Shew185_2071 6 None None None 152999752 Common - cobalamin biosynthesis protein CbiB Shew185_1219 85 COG1270 CbiB, Cobalamin biosynthesis protein CobD/CbiB Coenzyme metabolism 153000350 Common - cystathionine beta-lyase Shew185_1825 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 152999445 Common - ErfK/YbiS/YcfS/YnhG family protein Shew185_0909 84 COG1376 ErfK, Uncharacterized protein conserved in bacteria Function unknown 153002235 Common - hypothetical protein Shew185_3729 9 None None None 153000856 Common - major facilitator superfamily MFS_1 Shew185_2336 39 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 153000774 Common - protein of unknown function DUF1705 Shew185_2254 60 COG2194 COG2194, Predicted membrane-associated, metal-dependent hydrolase General function prediction only 153001799 Common - protein of unknown function UPF0044 Shew185_3290 96 COG1534 COG1534, Predicted RNA-binding protein containing KH domain, possibly ribosomal protein Translation, ribosomal structure and biogenesis 153001009 Common - Succinylarginine dihydrolase Shew185_2490 34 COG3724 AstB, Succinylarginine dihydrolase Amino acid transport and metabolism 153001514 Common - small GTP-binding protein Shew185_3001 226 COG1160 COG1160, Predicted GTPases General function prediction only 153001600 Common - protein of unknown function DUF405 Shew185_3087 54 COG2311 COG2311, Predicted membrane protein Function unknown 152999901 Common - magnesium transporter Shew185_1369 156 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 152998839 Common - two component transcriptional regulator, winged helix family Shew185_0286 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152999811 Common - hypothetical protein Shew185_1279 1 None None None 152999250 Common - ribosomal protein S6 Shew185_0711 191 COG0360 RpsF, Ribosomal protein S6 Translation, ribosomal structure and biogenesis 153001060 Common - hypothetical protein Shew185_2542 1 None None None 152999638 Common - sulfate transporter Shew185_1104 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 153001607 Common - ROK family protein Shew185_3094 33 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 153000665 Common - flavodoxin Shew185_2141 73 COG0716 FldA, Flavodoxins Energy production and conversion 153000724 Common - drug resistance transporter, Bcr/CflA subfamily Shew185_2203 187 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153000859 Common - helix-turn-helix- domain containing protein AraC type Shew185_2339 103 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 152999339 Common - efflux transporter, RND family, MFP subunit Shew185_0800 168 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153001363 Common - Propionyl-CoA carboxylase Shew185_2847 145 COG4799 COG4799, Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) Lipid metabolism 153001150 Common - putative CheW protein Shew185_2633 167 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 152998563 Common - glycyl-tRNA synthetase, beta subunit Shew185_0008 167 COG0751 GlyS, Glycyl-tRNA synthetase, beta subunit Translation, ribosomal structure and biogenesis 152998979 Common - conserved hypothetical protein 22 Shew185_0429 33 COG2731 EbgC, Beta-galactosidase, beta subunit Carbohydrate transport and metabolism 153002210 Common - hypothetical protein Shew185_3703 1 None None None 153001504 Common - cyd operon protein YbgT Shew185_2991 22 COG4890 COG4890, Predicted outer membrane lipoprotein Function unknown 153000785 Common - DTW domain containing protein Shew185_2265 37 COG3148 COG3148, Uncharacterized conserved protein Function unknown 152998832 Common - molybdopterin converting factor, subunit 1 Shew185_0279 42 COG1977 MoaD, Molybdopterin converting factor, small subunit Coenzyme metabolism 153000836 Common - protein-glutamate O-methyltransferase Shew185_2316 19 COG4487 COG4487, Uncharacterized protein conserved in bacteria Function unknown 153001767 Nonpathogen - hypothetical protein Shew185_3258 1 None None None 153001813 Common - PhoH family protein Shew185_3304 198 COG1702 PhoH, Phosphate starvation-inducible protein PhoH, predicted ATPase Signal transduction mechanisms 153000119 Common - cysteinyl-tRNA synthetase Shew185_1590 241 COG0215 CysS, Cysteinyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153000168 Common - peptidase M23B Shew185_1641 188 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 153001742 Common - TatD-related deoxyribonuclease Shew185_3233 234 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 153001465 Common - flagellar hook-associated protein 3 Shew185_2952 98 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 152998898 Common - integral membrane sensor signal transduction histidine kinase Shew185_0346 125 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 153001227 Common - virulence factor family protein Shew185_2711 19 COG3946 VirJ, Type IV secretory pathway, VirJ component Intracellular trafficking and secretion 153001953 Common - rRNA (guanine-N(2)-)-methyltransferase Shew185_3444 101 COG2813 RsmC, 16S RNA G1207 methylase RsmC Translation, ribosomal structure and biogenesis 152999766 Common - Na+/H+ antiporter NhaA Shew185_1233 106 COG3004 NhaA, Na+/H+ antiporter Inorganic ion transport and metabolism 153000070 Common - hypothetical protein Shew185_1541 9 COG2928 COG2928, Uncharacterized conserved protein Function unknown 152998722 Common - GCN5-related N-acetyltransferase Shew185_0169 21 COG0456 RimI, Acetyltransferases General function prediction only 152999043 Common - MSHA pilin protein MshD Shew185_0493 13 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 152999162 Common - L-asparaginase, type II Shew185_0619 141 COG0252 AnsB, L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D Amino acid transport and metabolism / Translation, ribosomal structure and biogenesis 153002159 Common - glycerophosphoryl diester phosphodiesterase Shew185_3652 50 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 153002662 Common - signal recognition particle-docking protein FtsY Shew185_4164 247 COG0552 FtsY, Signal recognition particle GTPase Intracellular trafficking and secretion 153001122 Common - beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA Shew185_2605 83 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 153001159 Common - alpha/beta hydrolase fold Shew185_2642 14 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153002440 Common - signaling modulator of AmpD, AmpE Shew185_3936 23 COG3725 AmpE, Membrane protein required for beta-lactamase induction Defense mechanisms 153002501 Common - ABC-type amino acid transport/signal transduction system Shew185_3998 12 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 152998738 Common - ribosomal protein L11 Shew185_0185 246 COG0080 RplK, Ribosomal protein L11 Translation, ribosomal structure and biogenesis 153000896 Common - heat shock protein Hsp20 Shew185_2376 65 COG0071 IbpA, Molecular chaperone (small heat shock protein) Posttranslational modification, protein turnover, chaperones 153000850 Common - helix-turn-helix- domain containing protein AraC type Shew185_2330 91 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 153001146 Common - peptidylprolyl isomerase FKBP-type Shew185_2629 124 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 153001848 Common - TonB-dependent receptor Shew185_3339 39 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 153000224 Nonpathogen - hypothetical protein Shew185_1699 1 None None None 153002454 Common - DEAD/DEAH box helicase domain protein Shew185_3951 235 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 153000868 Common - amino acid-binding ACT domain protein Shew185_2348 20 COG3603 COG3603, Uncharacterized conserved protein Function unknown 153002609 Common - molybdopterin oxidoreductase Shew185_4110 191 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 152999074 Common - transposase IS116/IS110/IS902 family protein Shew185_0524 89 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 153000077 Common - AMP-dependent synthetase and ligase Shew185_1548 200 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153001986 Common - Tetratricopeptide TPR_2 repeat protein Shew185_3477 27 COG3014 COG3014, Uncharacterized protein conserved in bacteria Function unknown 153002445 Common - type IV-A pilus assembly ATPase PilB Shew185_3942 224 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 152999736 Nonpathogen - hypothetical protein Shew185_1203 1 None None None 153001016 Common - metal dependent phosphohydrolase Shew185_2497 118 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 152999134 Common - P pilus assembly protein porin PapC-like protein Shew185_0590 5 COG3188 FimD, P pilus assembly protein, porin PapC Cell motility and secretion / Intracellular trafficking and secretion 152999405 Common - hypothetical protein Shew185_0869 4 None None None 152998956 Common - cell division protein FtsZ Shew185_0405 232 COG0206 FtsZ, Cell division GTPase Cell division and chromosome partitioning 153001536 Common - protein of unknown function DUF980 Shew185_3023 58 COG3228 COG3228, Uncharacterized protein conserved in bacteria Function unknown 153001704 Common - peptidase U32 Shew185_3192 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 153001712 Common - CgeB family protein Shew185_3201 21 COG4641 COG4641, Uncharacterized protein conserved in bacteria Function unknown 153000502 Common - N-6 DNA methylase Shew185_1977 161 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 153002243 Common - methyl-accepting chemotaxis sensory transducer Shew185_3737 156 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152999376 Common - response regulator receiver protein Shew185_0840 137 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 153002385 Common - cytochrome C biogenesis protein Shew185_3879 84 COG3088 CcmH, Uncharacterized protein involved in biosynthesis of c-type cytochromes Posttranslational modification, protein turnover, chaperones 152998604 Common - potassium uptake protein, TrkH family Shew185_0049 131 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 153000257 Common - diguanylate cyclase Shew185_1732 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152999588 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Shew185_1054 231 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 153002393 Common - Redoxin domain protein Shew185_3887 88 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 153000049 Common - beta-lactamase Shew185_1519 122 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 153001649 Common - Phosphopyruvate hydratase Shew185_3136 246 COG0148 Eno, Enolase Carbohydrate transport and metabolism 153000566 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s) Shew185_2042 179 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152998639 Common - hypothetical protein Shew185_0084 2 COG1668 NatB, ABC-type Na+ efflux pump, permease component Energy production and conversion / Inorganic ion transport and metabolism 152999452 Common - hypothetical protein Shew185_0916 1 None None None 153002206 Common - ferredoxin-dependent glutamate synthase Shew185_3699 202 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 153002476 Common - Diaminopimelate epimerase Shew185_3973 202 COG0253 DapF, Diaminopimelate epimerase Amino acid transport and metabolism 153000372 Nonpathogen - hypothetical protein Shew185_1847 1 None None None 152998632 Common - thioesterase superfamily protein Shew185_0077 38 COG0824 FcbC, Predicted thioesterase General function prediction only 152998665 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Shew185_0112 36 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 153001845 Common - galactokinase Shew185_3336 86 COG0153 GalK, Galactokinase Carbohydrate transport and metabolism 153001002 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Shew185_2483 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 153000911 Common - lipoprotein releasing system, transmembrane protein, LolC/E family Shew185_2391 161 COG4591 LolE, ABC-type transport system, involved in lipoprotein release, permease component Cell envelope biogenesis, outer membrane 153002634 Common - hypothetical protein Shew185_4135 1 None None None 153001171 Common - 4-hydroxyphenylpyruvate dioxygenase Shew185_2654 77 COG3185 COG3185, 4-hydroxyphenylpyruvate dioxygenase and related hemolysins Amino acid transport and metabolism / General function prediction only 152998752 Common - ribosomal protein L2 Shew185_0199 248 COG0090 RplB, Ribosomal protein L2 Translation, ribosomal structure and biogenesis 153000588 Common - electron transport complex, RnfABCDGE type, B subunit Shew185_2064 126 COG2878 COG2878, Predicted NADH:ubiquinone oxidoreductase, subunit RnfB Energy production and conversion 153000790 Common - hypothetical protein Shew185_2270 1 None None None 152999971 Common - PTS system, glucose-like IIB subunint Shew185_1439 49 COG1263 PtsG, Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific Carbohydrate transport and metabolism 152999863 Common - major facilitator superfamily MFS_1 Shew185_1331 74 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 153001839 Common - hypothetical protein Shew185_3330 1 None None None 152999930 Common - major facilitator superfamily MFS_1 Shew185_1398 66 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 153000509 Nonpathogen - hypothetical protein Shew185_1984 1 None None None 153002082 Common - methyl-accepting chemotaxis sensory transducer Shew185_3574 157 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153000024 Common - Enoyl-CoA hydratase/isomerase Shew185_1492 187 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 153002318 Common - hypothetical protein Shew185_3812 1 None None None 153002717 Common - Cytochrome o ubiquinol oxidase subunit I Shew185_4219 166 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 152999524 Common - putative transcriptional regulator, GntR family Shew185_0989 189 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 153000823 Common - Holliday junction DNA helicase RuvB Shew185_2303 235 COG2255 RuvB, Holliday junction resolvasome, helicase subunit DNA replication, recombination, and repair 153002117 Common - hypothetical protein Shew185_3610 49 COG2912 COG2912, Uncharacterized conserved protein Function unknown 152999818 Common - integral membrane sensor signal transduction histidine kinase Shew185_1286 106 COG4585 COG4585, Signal transduction histidine kinase Signal transduction mechanisms 153000839 Common - thiazole biosynthesis family protein Shew185_2319 166 COG2022 ThiG, Uncharacterized enzyme of thiazole biosynthesis Nucleotide transport and metabolism 153002418 Common - putative transcriptional regulator, MerR family Shew185_3912 133 COG0789 SoxR, Predicted transcriptional regulators Transcription 153001769 Common - hypothetical protein Shew185_3260 2 None None None 153001562 Common - hypothetical protein Shew185_3049 6 None None None 153000121 Common - trigger factor Shew185_1592 216 COG0544 Tig, FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) Posttranslational modification, protein turnover, chaperones 152998719 Common - putative outer membrane adhesin like proteiin Shew185_0166 120 None None None 152998782 Common - cytochrome c class I Shew185_0229 45 COG3245 CycB, Cytochrome c5 Energy production and conversion 152999676 Common - methyl-accepting chemotaxis sensory transducer Shew185_1142 154 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152999486 Common - extracellular solute-binding protein family 3 Shew185_0951 184 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 153000908 Common - serine O-acetyltransferase Shew185_2388 191 COG1045 CysE, Serine acetyltransferase Amino acid transport and metabolism 153002381 Common - FKBP-type peptidyl-prolyl isomerase domain protein Shew185_3875 133 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 152999169 Common - protein kinase Shew185_0626 45 COG4886 COG4886, Leucine-rich repeat (LRR) protein Function unknown 152999190 Common - putative transcriptional regulator, XRE family Shew185_0649 4 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 152999008 Common - cytochrome c, putative Shew185_0458 20 None None None 153001888 Nonpathogen - hypothetical protein Shew185_3379 1 None None None 153000235 Common - maf protein Shew185_1710 185 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 152998653 Common - molybdopterin oxidoreductase Fe4S4 region Shew185_0099 184 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 152999275 Common - hypothetical protein Shew185_0736 4 COG4859 COG4859, Uncharacterized protein conserved in bacteria Function unknown 153000462 Common - Nitrate reductase cytochrome c-type subunit (NapB) Shew185_1937 38 COG3043 NapB, Nitrate reductase cytochrome c-type subunit Energy production and conversion 153002467 Common - putative TIM-barrel protein, nifR3 family Shew185_3964 210 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 153001943 Common - NADH:ubiquinone oxidoreductase, subunit E Shew185_3434 76 COG2209 NqrE, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE Energy production and conversion 152999301 Common - protein of unknown function DUF1044 Shew185_0762 21 COG4737 COG4737, Uncharacterized protein conserved in bacteria Function unknown 153000624 Common - protein of unknown function DUF1320 Shew185_2100 23 COG4387 COG4387, Mu-like prophage protein gp36 Function unknown 153002039 Common - Radical SAM domain protein Shew185_3530 15 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 153000140 Common - methionine gamma-lyase Shew185_1611 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 153002578 Common - hypothetical protein Shew185_4079 2 None None None 153002460 Common - Alcohol dehydrogenase. zinc-binding type 1 Shew185_3957 156 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 152999991 Common - Ribonuclease H Shew185_1459 229 COG0164 RnhB, Ribonuclease HII DNA replication, recombination, and repair 152998805 Common - Quinone oxidoreductase putative YhdH/YhfP Shew185_0252 103 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 153002857 Common - transcriptional regulator, DeoR family Shew185_4361 116 COG1349 GlpR, Transcriptional regulators of sugar metabolism Transcription / Carbohydrate transport and metabolism 152999790 Common - ribosomal protein L19 Shew185_1257 216 COG0335 RplS, Ribosomal protein L19 Translation, ribosomal structure and biogenesis 152999841 Common - thioesterase superfamily protein Shew185_1309 36 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 152998989 Common - peptidase M4 thermolysin Shew185_0439 59 COG3227 LasB, Zinc metalloprotease (elastase) Amino acid transport and metabolism 153000654 Common - glucose-6-phosphate 1-dehydrogenase Shew185_2130 159 COG0364 Zwf, Glucose-6-phosphate 1-dehydrogenase Carbohydrate transport and metabolism 152998897 Common - two component transcriptional regulator, LuxR family Shew185_0345 213 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152999476 Common - hypothetical protein Shew185_0940 5 None None None 153001554 Common - pyrroline-5-carboxylate reductase Shew185_3041 213 COG0345 ProC, Pyrroline-5-carboxylate reductase Amino acid transport and metabolism 153002099 Common - UDP-N-acetylmuramate Shew185_3592 208 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 153001021 Common - ferric uptake regulator, Fur family Shew185_2502 196 COG0735 Fur, Fe2+/Zn2+ uptake regulation proteins Inorganic ion transport and metabolism 152999274 Nonpathogen - hypothetical protein Shew185_0735 1 None None None 153002433 Common - Endothelin-converting enzyme 1 Shew185_3928 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 153002168 Nonpathogen - hypothetical protein Shew185_3661 1 None None None 153001622 Common - band 7 protein Shew185_3109 51 COG2268 COG2268, Uncharacterized protein conserved in bacteria Function unknown 152998633 Common - HPP family protein? Shew185_0078 69 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 153002458 Common - hypothetical protein Shew185_3955 3 None None None 152999154 Common - IS66 Orf2 family protein Shew185_0611 51 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 153000873 Common - arsenate reductase and related Shew185_2353 106 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 152998579 Common - TrkA-N domain protein Shew185_0024 143 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 153000532 Common - regulator of ribonuclease activity A Shew185_2007 103 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 153000112 Common - FeoA family protein Shew185_1583 28 COG1918 FeoA, Fe2+ transport system protein A Inorganic ion transport and metabolism 152998762 Common - ribosomal protein S14 Shew185_0209 205 COG0199 RpsN, Ribosomal protein S14 Translation, ribosomal structure and biogenesis 152998709 Common - General secretion pathway protein K Shew185_0156 37 COG3156 PulK, Type II secretory pathway, component PulK Intracellular trafficking and secretion 152998826 Common - MOSC domain containing protein Shew185_0273 78 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 152999265 Common - hypothetical protein Shew185_0726 3 None None None 153002656 Common - alpha/beta hydrolase fold Shew185_4158 132 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152998948 Common - UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase Shew185_0397 211 COG0770 MurF, UDP-N-acetylmuramyl pentapeptide synthase Cell envelope biogenesis, outer membrane 152999424 Common - phage shock protein A, PspA Shew185_0888 27 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 152999186 Common - MATE efflux family protein Shew185_0643 167 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 153000299 Common - putative serine protein kinase, PrkA Shew185_1774 71 COG2766 PrkA, Putative Ser protein kinase Signal transduction mechanisms 153000727 Common - DsrE family protein Shew185_2206 43 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 153001663 Common - Auxin Efflux Carrier Shew185_3150 67 COG0679 COG0679, Predicted permeases General function prediction only 152999523 Common - hypothetical protein Shew185_0988 36 COG3686 COG3686, Predicted membrane protein Function unknown 153000720 Common - protein of unknown function DUF45 Shew185_2198 132 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 153002014 Common - flavocytochrome c Shew185_3505 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 153001569 Common - cytochrome B561 Shew185_3056 94 COG3038 CybB, Cytochrome B561 Energy production and conversion 153000189 Common - hypothetical protein Shew185_1662 88 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 153001452 Common - flagellar M-ring protein FliF Shew185_2936 124 COG1766 FliF, Flagellar biosynthesis/type III secretory pathway lipoprotein Cell motility and secretion / Intracellular trafficking and secretion 153001707 Common - Sterol-binding domain protein Shew185_3195 32 COG3154 COG3154, Putative lipid carrier protein Lipid metabolism 152999098 Common - hydratase/decarboxylase family protein Shew185_0548 40 COG3971 COG3971, 2-keto-4-pentenoate hydratase Secondary metabolites biosynthesis, transport, and catabolism 152999398 Common - hypothetical protein Shew185_0862 4 COG5589 COG5589, Uncharacterized conserved protein Function unknown 153002394 Common - 2-nitropropane dioxygenase NPD Shew185_3888 122 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 153002495 Common - hypothetical protein Shew185_3992 7 None None None 153001692 Common - transporter, hydrophobe/amphiphile efflux-1 (HAE1) family Shew185_3180 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 152999507 Common - methyl-accepting chemotaxis sensory transducer Shew185_0972 148 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153001192 Common - DSBA oxidoreductase Shew185_2675 64 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 152998683 Common - molybdopterin synthase sulfurylase MoeB Shew185_0130 223 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 152999436 Common - phosphate-selective porin O and P Shew185_0900 20 COG3746 OprP, Phosphate-selective porin Inorganic ion transport and metabolism 152998860 Common - GTP-binding protein TypA Shew185_0308 249 COG1217 TypA, Predicted membrane GTPase involved in stress response Signal transduction mechanisms 153000302 Common - uracil-xanthine permease Shew185_1777 123 COG2233 UraA, Xanthine/uracil permeases Nucleotide transport and metabolism 153002132 Common - Endothelin-converting enzyme 1 Shew185_3625 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 153001138 Common - hypothetical protein Shew185_2621 10 None None None 152999567 Common - pilin, putative Shew185_1033 5 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 153000740 Common - ribosomal protein L20 Shew185_2219 216 COG0292 RplT, Ribosomal protein L20 Translation, ribosomal structure and biogenesis 153001204 Common - C4-dicarboxylate transporter/malic acid transport protein Shew185_2687 42 COG1275 TehA, Tellurite resistance protein and related permeases Inorganic ion transport and metabolism 153002051 Nonpathogen - hypothetical protein Shew185_3542 1 None None None 152999285 Common - transcriptional regulator, XRE family Shew185_0746 2 COG1396 HipB, Predicted transcriptional regulators Transcription 152999286 Nonpathogen - hypothetical protein Shew185_0747 1 None None None 153001901 Common - protein of unknown function DUF692 Shew185_3392 62 COG3220 COG3220, Uncharacterized protein conserved in bacteria Function unknown 152999336 Common - molybdate ABC transporter, inner membrane subunit Shew185_0797 226 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 153001114 Common - periplasmic glucan biosynthesis protein MdoG Shew185_2597 50 COG3131 MdoG, Periplasmic glucans biosynthesis protein Inorganic ion transport and metabolism 153000472 Common - hypothetical protein Shew185_1947 11 COG3608 COG3608, Predicted deacylase General function prediction only 153000707 Nonpathogen - hypothetical protein Shew185_2183 1 None None None 152999366 Common - methylation site containing protein Shew185_0830 25 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 153002477 Common - diaminopimelate decarboxylase Shew185_3974 217 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 153000518 Nonpathogen - hypothetical protein Shew185_1993 1 None None None 152998888 Common - thioester dehydrase family protein Shew185_0336 24 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 153001501 Common - acriflavin resistance protein Shew185_2988 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 153001506 Common - cytochrome bd ubiquinol oxidase subunit I Shew185_2993 166 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 153001319 Common - hypothetical protein Shew185_2803 21 None None None 152999838 Common - TonB-dependent receptor plug Shew185_1306 121 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 153001199 Common - protein of unknown function DUF540 Shew185_2682 45 COG2981 CysZ, Uncharacterized protein involved in cysteine biosynthesis Amino acid transport and metabolism 152999102 Common - DEAD/DEAH box helicase domain protein Shew185_0552 234 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 153000783 Common - phage integrase family protein Shew185_2263 49 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 152999962 Common - hypothetical protein Shew185_1430 23 None None None 152999896 Common - two component transcriptional regulator, winged helix family Shew185_1364 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153000092 Common - transferase hexapeptide repeat containing protein Shew185_1563 172 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 153000682 Common - hypothetical protein Shew185_2158 31 COG2992 Bax, Uncharacterized FlgJ-related protein General function prediction only 152998965 Common - Sec-independent protein translocase, TatC subunit Shew185_0414 205 COG0805 TatC, Sec-independent protein secretion pathway component TatC Intracellular trafficking and secretion 153002045 Common - protein of unknown function DUF481 Shew185_3536 38 COG3137 COG3137, Putative salt-induced outer membrane protein Cell envelope biogenesis, outer membrane 153001800 Common - protein-export membrane protein SecF Shew185_3291 218 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 153000401 Common - hypothetical protein Shew185_1876 45 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 153001082 Common - Cobyrinic acid ac-diamide synthase Shew185_2565 199 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 153001991 Common - protein of unknown function DUF72 Shew185_3482 104 COG1801 COG1801, Uncharacterized conserved protein Function unknown 153001836 Common - Ferritin Dps family protein Shew185_3327 146 COG0783 Dps, DNA-binding ferritin-like protein (oxidative damage protectant) Inorganic ion transport and metabolism 153000951 Common - Dihydroorotate oxidase Shew185_2432 234 COG0167 PyrD, Dihydroorotate dehydrogenase Nucleotide transport and metabolism 153002678 Common - Cytochrome c oxidase subunit II Shew185_4180 157 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 153000292 Common - hypothetical protein Shew185_1767 9 None None None 152999141 Common - hypothetical protein Shew185_0598 1 None None None 153000336 Common - PKD domain containing protein Shew185_1811 62 COG2374 COG2374, Predicted extracellular nuclease General function prediction only 153000937 Common - ATP phosphoribosyltransferase Shew185_2418 212 COG0040 HisG, ATP phosphoribosyltransferase Amino acid transport and metabolism 152999216 Common - protein of unknown function RIO1 Shew185_0676 66 COG1718 RIO1, Serine/threonine protein kinase involved in cell cycle control Signal transduction mechanisms / Cell division and chromosome partitioning 153000497 Nonpathogen - hypothetical protein Shew185_1972 1 None None None 153000051 Nonpathogen - hypothetical protein Shew185_1521 3 None None None 152999071 Common - Methyltransferase type 11 Shew185_0521 47 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153000905 Common - FeS cluster assembly scaffold IscU Shew185_2385 148 COG0822 IscU, NifU homolog involved in Fe-S cluster formation Energy production and conversion 153001187 Common - hypothetical protein Shew185_2670 3 None None None 153000773 Common - diguanylate cyclase Shew185_2253 179 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152999654 Common - riboflavin biosynthesis protein RibF Shew185_1120 211 COG0196 RibF, FAD synthase Coenzyme metabolism 153000644 Common - hypothetical protein Shew185_2120 2 COG3691 COG3691, Uncharacterized protein conserved in bacteria Function unknown 153001467 Common - flagellar rod assembly protein/muramidase FlgJ Shew185_2954 72 COG1705 FlgJ, Muramidase (flagellum-specific) Cell motility and secretion / Intracellular trafficking and secretion 152998881 Common - hypothetical protein Shew185_0329 4 None None None 153000900 Common - alpha-L-glutamate ligase, RimK family Shew185_2380 150 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 152998730 Common - glutamate racemase Shew185_0177 190 COG0796 MurI, Glutamate racemase Cell envelope biogenesis, outer membrane 153002827 Common - pantetheine-phosphate adenylyltransferase Shew185_4331 208 COG0669 CoaD, Phosphopantetheine adenylyltransferase Coenzyme metabolism 152999958 Common - Syd family protein Shew185_1426 19 None None None 152999858 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Shew185_1326 192 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 153001613 Common - homocysteine S-methyltransferase Shew185_3100 121 COG2040 MHT1, Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) Amino acid transport and metabolism 153002264 Common - glutamine amidotransferase of anthranilate synthase Shew185_3758 239 COG0512 PabA, Anthranilate/para-aminobenzoate synthases component II Amino acid transport and metabolism / Coenzyme metabolism 152999109 Common - hypothetical protein Shew185_0559 15 COG4688 COG4688, Uncharacterized protein conserved in bacteria Function unknown 153000530 Common - protein of unknown function DUF885 Shew185_2005 42 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 152999784 Common - protein of unknown function DUF21 Shew185_1251 218 COG4536 CorB, Putative Mg2+ and Co2+ transporter CorB Inorganic ion transport and metabolism 152999341 Common - RND efflux system, outer membrane lipoprotein, NodT family Shew185_0802 122 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 152999497 Common - hypothetical protein Shew185_0962 2 None None None 152998940 Common - membrane protein involved in aromatic hydrocarbon degradation Shew185_0389 84 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 152999374 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Shew185_0838 231 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 153000180 Common - GTP cyclohydrolase II Shew185_1653 198 COG0807 RibA, GTP cyclohydrolase II Coenzyme metabolism 152999747 Common - tyrosyl-tRNA synthetase Shew185_1214 240 COG0162 TyrS, Tyrosyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153000035 Common - FAD linked oxidase domain protein Shew185_1503 64 COG0277 GlcD, FAD/FMN-containing dehydrogenases Energy production and conversion 153000398 Common - hypothetical protein Shew185_1873 3 None None None 153000915 Common - transcription-repair coupling factor Shew185_2395 231 COG1197 Mfd, Transcription-repair coupling factor (superfamily II helicase) DNA replication, recombination, and repair / Transcription 152999537 Common - curli production assembly/transport component CsgE, putative Shew185_1003 3 None None None 153001418 Common - lipopolysaccharide biosynthesis protein Shew185_2902 17 COG3765 WzzB, Chain length determinant protein Cell envelope biogenesis, outer membrane 153000141 Common - competence protein ComEA helix-hairpin-helix repeat protein Shew185_1612 120 COG1555 ComEA, DNA uptake protein and related DNA-binding proteins DNA replication, recombination, and repair 152999873 Common - ATP-NAD/AcoX kinase Shew185_1341 236 COG0061 COG0061, Predicted sugar kinase Carbohydrate transport and metabolism 153001185 Common - transcriptional regulator, GntR family Shew185_2668 136 COG1802 GntR, Transcriptional regulators Transcription 153002194 Common - NAD-dependent epimerase/dehydratase Shew185_3687 66 COG2910 COG2910, Putative NADH-flavin reductase General function prediction only 152998892 Common - acyl carrier protein, putative Shew185_0340 47 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152999000 Common - hypothetical protein Shew185_0450 1 None None None 152999003 Common - transcriptional regulator, LysR family Shew185_0453 140 COG0583 LysR, Transcriptional regulator Transcription 153000760 Common - Methyltransferase type 12 Shew185_2240 14 None None None 152999562 Common - TonB-dependent receptor Shew185_1028 87 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 152999465 Common - sulfate adenylyltransferase, large subunit Shew185_0929 249 COG2895 CysN, GTPases - Sulfate adenylate transferase subunit 1 Inorganic ion transport and metabolism 153000683 Common - hypothetical protein Shew185_2159 5 None None None 152999649 Common - protein of unknown function DUF328 Shew185_1115 89 COG3022 COG3022, Uncharacterized protein conserved in bacteria Function unknown 152999031 Common - hypothetical protein Shew185_0481 4 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 152999874 Common - GrpE protein Shew185_1342 229 COG0576 GrpE, Molecular chaperone GrpE (heat shock protein) Posttranslational modification, protein turnover, chaperones 153000623 Common - Rho termination factor domain protein Shew185_2099 1 None None None 152999851 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Shew185_1319 196 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 153001277 Common - aspartate-semialdehyde dehydrogenase Shew185_2761 236 COG0136 Asd, Aspartate-semialdehyde dehydrogenase Amino acid transport and metabolism 153002151 Common - TonB-dependent receptor Shew185_3644 126 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 153002157 Common - hypothetical protein Shew185_3650 5 None None None 152999188 Common - chaperonin GroEL Shew185_0645 247 COG0459 GroL, Chaperonin GroEL (HSP60 family) Posttranslational modification, protein turnover, chaperones 153001787 Common - tRNA pseudouridine synthase B Shew185_3278 245 COG0130 TruB, Pseudouridine synthase Translation, ribosomal structure and biogenesis 153000125 Common - histone family protein DNA-binding protein Shew185_1596 204 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 153000590 Common - diguanylate cyclase/phosphodiesterase Shew185_2066 160 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152998936 Common - 2-isopropylmalate synthase Shew185_0385 216 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 153000258 Common - Na+ antiporter NhaC Shew185_1733 29 COG2056 COG2056, Predicted permease General function prediction only 153001459 Common - flagellar hook-associated 2 domain protein Shew185_2943 107 COG1345 FliD, Flagellar capping protein Cell motility and secretion 152999680 Common - N-acetylglucosamine-6-phosphate deacetylase Shew185_1146 118 COG1820 NagA, N-acetylglucosamine-6-phosphate deacetylase Carbohydrate transport and metabolism 152999888 Common - hypothetical protein Shew185_1356 5 None None None 153002488 Common - type I secretion outer membrane protein, TolC family Shew185_3985 132 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 153000635 Common - hypothetical protein Shew185_2111 1 None None None 153000440 Common - hydrogenase (NiFe) small subunit HydA Shew185_1915 77 COG1740 HyaA, Ni,Fe-hydrogenase I small subunit Energy production and conversion 153000847 Common - NUDIX hydrolase Shew185_2327 14 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 152998656 Common - formate dehydrogenase accessory protein FdhE Shew185_0103 40 COG3058 FdhE, Uncharacterized protein involved in formate dehydrogenase formation Posttranslational modification, protein turnover, chaperones 152999640 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Shew185_1106 156 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153002429 Common - ISSod10, transposase OrfA Shew185_3924 7 COG3415 COG3415, Transposase and inactivated derivatives DNA replication, recombination, and repair 153002865 Common - ATP synthase F0, B subunit Shew185_4369 165 COG0711 AtpF, F0F1-type ATP synthase, subunit b Energy production and conversion 152999755 Common - Glutamate synthase (ferredoxin) Shew185_1222 203 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 152999500 Common - dienelactone hydrolase Shew185_0965 115 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 153000216 Nonpathogen - hypothetical protein Shew185_1690 1 None None None 153000244 Common - hypothetical protein Shew185_1719 1 None None None 153001761 Nonpathogen - hypothetical protein Shew185_3252 1 None None None 152999910 Common - Glutathione S-transferase domain Shew185_1378 107 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 153000288 Common - pyridoxamine 5'-phosphate oxidase Shew185_1763 132 COG0259 PdxH, Pyridoxamine-phosphate oxidase Coenzyme metabolism 153001031 Common - Succinate dehydrogenase cytochrome b556 subunit Shew185_2512 93 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 152999049 Common - Rod shape-determining protein MreD Shew185_0499 62 COG2891 MreD, Cell shape-determining protein Cell envelope biogenesis, outer membrane 153002234 Common - hypothetical protein Shew185_3728 6 COG1697 COG1697, DNA topoisomerase VI, subunit A DNA replication, recombination, and repair 153000801 Common - 3-phosphoshikimate 1-carboxyvinyltransferase Shew185_2281 228 COG0128 AroA, 5-enolpyruvylshikimate-3-phosphate synthase Amino acid transport and metabolism 153000705 Common - hypothetical protein Shew185_2181 10 None None None 153000313 Common - response regulator receiver protein Shew185_1788 128 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152998854 Common - sodium:dicarboxylate symporter Shew185_0301 160 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 153001250 Common - ferric iron reductase Shew185_2734 10 COG4114 FhuF, Uncharacterized Fe-S protein General function prediction only 153000064 Common - phosphate ABC transporter, inner membrane subunit PstA Shew185_1534 224 COG4985 COG4985, ABC-type phosphate transport system, auxiliary component Inorganic ion transport and metabolism 152999471 Common - major facilitator superfamily MFS_1 Shew185_0935 24 None None None 152999757 Common - Hpt protein Shew185_1224 22 COG2198 ArcB, FOG: HPt domain Signal transduction mechanisms 153000347 Common - hypothetical protein Shew185_1822 62 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 152999722 Common - DNA primase Shew185_1189 215 COG0358 DnaG, DNA primase (bacterial type) DNA replication, recombination, and repair 153000069 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Shew185_1540 41 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 152999547 Common - hypothetical protein Shew185_1013 9 COG4519 COG4519, Uncharacterized protein conserved in bacteria Function unknown 153000340 Common - hypothetical protein Shew185_1815 4 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 153000593 Common - prophage MuSo1, DNA transposition protein, putative Shew185_2069 19 COG2842 COG2842, Uncharacterized ATPase, putative transposase General function prediction only 153001096 Common - hypothetical protein Shew185_2579 19 COG2267 PldB, Lysophospholipase Lipid metabolism 153000695 Common - hypothetical protein Shew185_2171 4 None None None 153002086 Common - hypothetical protein Shew185_3578 43 COG4637 COG4637, Predicted ATPase General function prediction only 153001164 Common - hypothetical protein Shew185_2647 1 None None None 153002187 Common - yecA family protein Shew185_3680 41 COG3079 COG3079, Uncharacterized protein conserved in bacteria Function unknown 153002252 Common - Sel1 domain protein repeat-containing protein Shew185_3746 86 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 153000601 Common - Mor transcription activator domain protein Shew185_2077 14 COG5566 COG5566, Uncharacterized conserved protein Function unknown 153001278 Common - D-isomer specific 2-hydroxyacid dehydrogenase catalytic region Shew185_2762 230 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 152999063 Common - TonB-dependent receptor Shew185_0513 88 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 153000456 Common - membrane protein Shew185_1931 38 COG4325 COG4325, Predicted membrane protein Function unknown 153002442 Common - nicotinate-nucleotide pyrophosphorylase Shew185_3939 204 COG0157 NadC, Nicotinate-nucleotide pyrophosphorylase Coenzyme metabolism 153002563 Common - ThiJ/PfpI domain protein Shew185_4063 87 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 153001734 Common - transposase Shew185_3225 9 None None None 153002002 Common - formate dehydrogenase, alpha subunit Shew185_3493 235 COG3383 COG3383, Uncharacterized anaerobic dehydrogenase General function prediction only 153001743 Common - hypothetical protein Shew185_3234 1 None None None 153000358 Common - hypothetical protein Shew185_1833 4 None None None 152998597 Common - peptidase M23B Shew185_0042 190 COG4942 COG4942, Membrane-bound metallopeptidase Cell division and chromosome partitioning 152998623 Common - hypothetical protein Shew185_0068 1 None None None 152999515 Common - cobyric acid synthase CobQ Shew185_0980 153 COG1492 CobQ, Cobyric acid synthase Coenzyme metabolism 153001209 Common - protein of unknown function DUF412 Shew185_2692 23 COG3092 COG3092, Uncharacterized protein conserved in bacteria Function unknown 152998672 Common - phospholipid/glycerol acyltransferase Shew185_0119 47 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 153000618 Nonpathogen - hypothetical protein Shew185_2094 1 None None None 153002667 Common - hypothetical protein Shew185_4169 1 None None None 152999613 Common - NADPH-dependent FMN reductase Shew185_1079 20 COG0431 COG0431, Predicted flavoprotein General function prediction only 152999148 Common - integral membrane sensor signal transduction histidine kinase Shew185_0605 201 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152999595 Common - secretion protein HlyD family protein Shew185_1061 97 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 152998926 Common - phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase Shew185_0375 234 COG0452 Dfp, Phosphopantothenoylcysteine synthetase/decarboxylase Coenzyme metabolism 153001635 Common - carbon storage regulator, CsrA Shew185_3122 81 COG1551 CsrA, Carbon storage regulator (could also regulate swarming and quorum sensing) Signal transduction mechanisms 152999540 Common - transcriptional regulator, TetR family Shew185_1006 129 COG1309 AcrR, Transcriptional regulator Transcription 153001631 Common - permease YjgP/YjgQ family protein Shew185_3118 85 COG0795 COG0795, Predicted permeases General function prediction only 153002334 Common - hypothetical protein Shew185_3828 15 None None None 153002020 Nonpathogen - PepSY-associated TM helix domain protein Shew185_3511 8 None None None 152999829 Common - hypothetical protein Shew185_1297 2 None None None 153002287 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Shew185_3781 227 COG0111 SerA, Phosphoglycerate dehydrogenase and related dehydrogenases Amino acid transport and metabolism 153002092 Common - peptidase S8 and S53 subtilisin kexin sedolisin Shew185_3585 65 None None None 153002676 Common - SOS-response transcriptional repressor, LexA Shew185_4178 169 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 153002576 Common - phosphoglycolate phosphatase Shew185_4076 207 COG0546 Gph, Predicted phosphatases General function prediction only 153001282 Common - YfcL protein Shew185_2766 16 None None None 153000001 Common - 3'(2'),5'-bisphosphate nucleotidase Shew185_1469 176 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 153002345 Nonpathogen - hypothetical protein Shew185_3839 1 None None None 153000179 Common - hypothetical protein Shew185_1652 13 None None None 152999299 Nonpathogen - hypothetical protein Shew185_0760 1 None None None 153001676 Common - beta-lactamase domain protein Shew185_3164 33 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 153002094 Common - Integrase catalytic region Shew185_3587 138 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 153002023 Common - Leucyl aminopeptidase Shew185_3514 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 153002374 Common - copper ABC transporter, permease protein Shew185_3868 30 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 152999996 Common - putative cold-shock DNA-binding domain protein Shew185_1464 181 COG1278 CspC, Cold shock proteins Transcription 153002850 Common - alpha/beta hydrolase fold Shew185_4354 82 COG2267 PldB, Lysophospholipase Lipid metabolism 153000931 Common - TonB-dependent receptor Shew185_2412 129 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 152999050 Common - maf protein Shew185_0500 196 COG0424 Maf, Nucleotide-binding protein implicated in inhibition of septum formation Cell division and chromosome partitioning 153000418 Common - cell division topological specificity factor MinE Shew185_1893 81 COG0851 MinE, Septum formation topological specificity factor Cell division and chromosome partitioning 153001145 Common - Peptidase M1 membrane alanine aminopeptidase Shew185_2628 164 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 152999383 Common - poly(A) polymerase Shew185_0847 198 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 152998704 Common - general secretion pathway protein F Shew185_0151 147 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 153001608 Common - peptidase M24 Shew185_3095 223 COG0006 PepP, Xaa-Pro aminopeptidase Amino acid transport and metabolism 152999778 Common - Ribonuclease III Shew185_1245 217 COG0571 Rnc, dsRNA-specific ribonuclease Transcription 153000351 Common - integral membrane sensor signal transduction histidine kinase Shew185_1826 217 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153000604 Nonpathogen - hypothetical protein Shew185_2080 1 None None None 152999307 Common - hypothetical protein Shew185_0768 3 None None None 152999712 Common - SapC family protein Shew185_1178 21 None None None 153001345 Common - protein of unknown function DUF606 Shew185_2829 65 COG3238 COG3238, Uncharacterized protein conserved in bacteria Function unknown 152999666 Common - type IV pilus biogenesis protein, putative Shew185_1132 14 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 153001732 Common - phosphoserine phosphatase SerB Shew185_3223 149 COG0560 SerB, Phosphoserine phosphatase Amino acid transport and metabolism 153001671 Common - riboflavin biosynthesis protein RibD Shew185_3159 224 COG0117 RibD, Pyrimidine deaminase Coenzyme metabolism 153002170 Common - diguanylate cyclase Shew185_3663 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152999010 Common - cytochrome c family protein Shew185_0460 2 COG2863 COG2863, Cytochrome c553 Energy production and conversion 153001479 Common - anti-sigma-28 factor, FlgM Shew185_2966 9 COG2747 FlgM, Negative regulator of flagellin synthesis (anti-sigma28 factor) Transcription / Cell motility and secretion / Intracellular trafficking and secretion 153000487 Nonpathogen - hypothetical protein Shew185_1962 1 None None None 152999882 Common - transcriptional regulator, LysR family Shew185_1350 184 COG0583 LysR, Transcriptional regulator Transcription 152999248 Common - major facilitator superfamily MFS_1 Shew185_0709 65 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153001493 Common - TPR repeat-containing protein Shew185_2980 10 COG2604 COG2604, Uncharacterized protein conserved in bacteria Function unknown 152999590 Common - Tetratricopeptide TPR_2 repeat protein Shew185_1056 3 None None None 153000276 Common - biotin synthase Shew185_1751 179 COG0502 BioB, Biotin synthase and related enzymes Coenzyme metabolism 153002516 Common - diguanylate cyclase Shew185_4014 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153002632 Nonpathogen - hypothetical protein Shew185_4133 1 None None None 152999948 Common - PfaD family protein Shew185_1416 23 COG2070 COG2070, Dioxygenases related to 2-nitropropane dioxygenase General function prediction only 153000714 Common - hypothetical protein Shew185_2192 2 None None None 153002602 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Shew185_4103 81 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 152998999 Common - bifunctional deaminase-reductase domain protein Shew185_0449 70 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 153002468 Common - transcriptional regulator, Fis family Shew185_3965 97 COG2901 Fis, Factor for inversion stimulation Fis, transcriptional activator Transcription / DNA replication, recombination, and repair 153001714 Common - putative transposase Shew185_3203 31 None None None 153001169 Common - transcriptional regulator, LysR family Shew185_2652 167 COG0583 LysR, Transcriptional regulator Transcription 153000796 Common - hypothetical protein Shew185_2276 60 COG2956 COG2956, Predicted N-acetylglucosaminyl transferase Carbohydrate transport and metabolism 153002461 Common - Antibiotic biosynthesis monooxygenase Shew185_3958 41 COG1359 COG1359, Uncharacterized conserved protein Function unknown 152999803 Common - peptidylprolyl isomerase FKBP-type Shew185_1270 127 COG1047 SlpA, FKBP-type peptidyl-prolyl cis-trans isomerases 2 Posttranslational modification, protein turnover, chaperones 153002289 Common - BFD domain protein (2Fe-2S)-binding domain protein Shew185_3783 36 COG2906 Bfd, Bacterioferritin-associated ferredoxin Inorganic ion transport and metabolism 153002271 Common - HflK protein Shew185_3765 195 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 153001680 Common - hypothetical protein Shew185_3168 27 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 153000925 Common - L-serine dehydratase 1 Shew185_2406 124 COG1760 SdaA, L-serine deaminase Amino acid transport and metabolism 153001858 Common - alpha/beta hydrolase fold Shew185_3349 6 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152999707 Common - luciferase family protein Shew185_1173 116 COG2141 COG2141, Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases Energy production and conversion 153000564 Common - glucose/galactose transporter Shew185_2040 52 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 153000226 Common - hypothetical protein Shew185_1701 7 None None None 153000233 Common - pseudouridine synthase, RluA family Shew185_1708 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 153002695 Common - response regulator receiver protein Shew185_4197 2 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 153002036 Common - DEAD/DEAH box helicase domain protein Shew185_3527 234 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 152998693 Common - lipoprotein, putative Shew185_0140 18 None None None 152998992 Common - hypothetical protein Shew185_0442 4 None None None 153002144 Common - diguanylate cyclase Shew185_3637 177 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153001116 Common - excinuclease ABC, C subunit Shew185_2599 223 COG0322 UvrC, Nuclease subunit of the excinuclease complex DNA replication, recombination, and repair 152998818 Common - protein of unknown function DUF1255 Shew185_0265 53 COG3123 COG3123, Uncharacterized protein conserved in bacteria Function unknown 153000511 Nonpathogen - hypothetical protein Shew185_1986 2 None None None 153000798 Common - integration host factor, beta subunit Shew185_2278 207 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 153002761 Common - hypothetical protein Shew185_4263 4 None None None 153002589 Common - penicillin-binding protein, 1A family Shew185_4090 200 COG5009 MrcA, Membrane carboxypeptidase/penicillin-binding protein Cell envelope biogenesis, outer membrane 153000914 Common - hypothetical protein Shew185_2394 7 None None None 153000884 Common - hypothetical protein Shew185_2364 1 None None None 152999488 Common - transcriptional regulator, LysR family Shew185_0953 181 COG0583 LysR, Transcriptional regulator Transcription 153000994 Common - hypothetical protein Shew185_2475 3 None None None 153002719 Common - Cytochrome o ubiquinol oxidase subunit IV Shew185_4221 61 COG3125 CyoD, Heme/copper-type cytochrome/quinol oxidase, subunit 4 Energy production and conversion 152999629 Common - sodium:dicarboxylate symporter Shew185_1095 164 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 152999258 Common - putative chemotaxis protein CheX Shew185_0719 27 COG1406 COG1406, Predicted inhibitor of MCP methylation, homolog of CheC Cell motility and secretion 152999522 Common - GCN5-related N-acetyltransferase Shew185_0987 26 COG0456 RimI, Acetyltransferases General function prediction only 152998602 Common - HI0933 family protein Shew185_0047 141 COG2081 COG2081, Predicted flavoproteins General function prediction only 153002352 Common - Antibiotic biosynthesis monooxygenase Shew185_3846 32 COG2329 COG2329, Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides General function prediction only 153000622 Common - prophage MuSo1, major head subunit, putative Shew185_2098 17 COG4397 COG4397, Mu-like prophage major head subunit gpT General function prediction only 153000629 Common - hypothetical protein Shew185_2105 10 None None None 152998739 Common - ribosomal protein L1 Shew185_0186 247 COG0081 RplA, Ribosomal protein L1 Translation, ribosomal structure and biogenesis 153000460 Common - NapD family protein Shew185_1935 24 COG3062 NapD, Uncharacterized protein involved in formation of periplasmic nitrate reductase Inorganic ion transport and metabolism 153001750 Common - CRISPR-associated protein Cas1 Shew185_3241 27 COG1518 COG1518, Uncharacterized protein predicted to be involved in DNA repair DNA replication, recombination, and repair 153000895 Common - acetolactate synthase, small subunit Shew185_2375 192 COG0440 IlvH, Acetolactate synthase, small (regulatory) subunit Amino acid transport and metabolism 152999579 Common - ApaG domain protein Shew185_1045 89 COG2967 ApaG, Uncharacterized protein affecting Mg2+/Co2+ transport Inorganic ion transport and metabolism 153002745 Common - AbgT putative transporter Shew185_4247 41 COG2978 AbgT, Putative p-aminobenzoyl-glutamate transporter Coenzyme metabolism 152999246 Common - ribonuclease R Shew185_0707 202 COG0557 VacB, Exoribonuclease R Transcription 153000026 Common - 3-hydroxyisobutyrate dehydrogenase Shew185_1494 169 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 153001870 Nonpathogen - hypothetical protein Shew185_3361 1 None None None 153001878 Common - hypothetical protein Shew185_3369 2 None None None 153001045 Common - Cytochrome-c peroxidase Shew185_2526 94 COG1858 MauG, Cytochrome c peroxidase Inorganic ion transport and metabolism 153000500 Nonpathogen - hypothetical protein Shew185_1975 1 None None None 153001511 Common - GMP synthase, large subunit Shew185_2998 239 COG0519 GuaA, GMP synthase, PP-ATPase domain/subunit Nucleotide transport and metabolism 153001065 Common - cytoplasmic chaperone TorD family protein Shew185_2547 13 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 153000298 Common - protein of unknown function DUF444 Shew185_1773 71 COG2718 COG2718, Uncharacterized conserved protein Function unknown 153002193 Common - arginine repressor, ArgR Shew185_3686 78 COG1438 ArgR, Arginine repressor Transcription 152999448 Common - rfaE bifunctional protein Shew185_0912 155 COG2870 RfaE, ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase Cell envelope biogenesis, outer membrane 152999119 Common - transposase IS4 family protein Shew185_0572 33 COG5433 COG5433, Transposase DNA replication, recombination, and repair 153001320 Common - protein-export membrane protein SecF Shew185_2804 202 COG0341 SecF, Preprotein translocase subunit SecF Intracellular trafficking and secretion 152999776 Common - GTP-binding protein LepA Shew185_1243 249 COG0481 LepA, Membrane GTPase LepA Cell envelope biogenesis, outer membrane 153002119 Common - GCN5-related N-acetyltransferase Shew185_3612 30 COG0456 RimI, Acetyltransferases General function prediction only 153000544 Common - Protein of unknown function DUF1974 Shew185_2019 147 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 153002553 Common - Ornithine decarboxylase Shew185_4053 82 COG1982 LdcC, Arginine/lysine/ornithine decarboxylases Amino acid transport and metabolism 153001007 Common - hypothetical protein Shew185_2488 7 None None None 153002388 Common - putative transcriptional regulator, XRE family Shew185_3882 51 COG3655 COG3655, Predicted transcriptional regulator Transcription 152999006 Common - polysaccharide deacetylase Shew185_0456 86 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 152998958 Common - hypothetical protein Shew185_0407 13 COG4701 COG4701, Uncharacterized protein conserved in bacteria Function unknown 153001485 Nonpathogen - hypothetical protein Shew185_2972 1 None None None 153001152 Common - peptidase S16 lon domain protein Shew185_2635 32 COG2802 COG2802, Uncharacterized protein, similar to the N-terminal domain of Lon protease General function prediction only 152999903 Common - YfaZ family protein Shew185_1371 12 None None None 153001109 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Shew185_2592 203 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 153001534 Common - extracellular solute-binding protein family 1 Shew185_3021 39 COG1653 UgpB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 152999966 Common - hypothetical protein Shew185_1434 10 None None None 153000033 Common - Lipocalin family protein Shew185_1501 67 COG3040 Blc, Bacterial lipocalin Cell envelope biogenesis, outer membrane 153002739 Common - protein of unknown function DUF548 Shew185_4241 50 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 153001100 Common - Ferrochelatase Shew185_2583 159 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 152999161 Common - aspartate ammonia-lyase Shew185_0618 219 COG1027 AspA, Aspartate ammonia-lyase Amino acid transport and metabolism 153000828 Common - diguanylate cyclase Shew185_2308 188 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153001377 Common - Thymidine kinase Shew185_2861 99 COG1435 Tdk, Thymidine kinase Nucleotide transport and metabolism 153000387 Common - transcriptional regulator, XRE family Shew185_1862 2 COG1396 HipB, Predicted transcriptional regulators Transcription 153000858 Common - hypothetical protein Shew185_2338 2 None None None 153000853 Common - alpha/beta hydrolase fold Shew185_2333 33 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153001811 Common - hypothetical protein Shew185_3302 1 None None None 153002410 Common - diguanylate cyclase with PAS/PAC sensor Shew185_3904 185 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153000675 Common - Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase Shew185_2151 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 153002102 Common - hypothetical protein Shew185_3595 21 None None None 153000821 Common - two component transcriptional regulator, winged helix family Shew185_2301 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153002642 Common - Sel1 domain protein repeat-containing protein Shew185_4143 78 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 153002793 Common - hypothetical protein Shew185_4297 1 None None None 153001355 Common - Extradiol ring-cleavage dioxygenase class III protein subunit B Shew185_2839 86 COG3384 COG3384, Uncharacterized conserved protein Function unknown 153001842 Nonpathogen - membrane or secreted protein Shew185_3333 3 None None None 153001390 Common - helix-turn-helix- domain containing protein AraC type Shew185_2874 87 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 153001935 Common - transcriptional regulator, LysR family Shew185_3426 169 COG0583 LysR, Transcriptional regulator Transcription 153001525 Common - DoxX family protein Shew185_3012 32 COG2259 COG2259, Predicted membrane protein Function unknown 153001560 Common - protein of unknown function DUF885 Shew185_3047 44 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 153000736 Common - cell divisionFtsK/SpoIIIE Shew185_2215 199 COG1674 FtsK, DNA segregation ATPase FtsK/SpoIIIE and related proteins Cell division and chromosome partitioning 152998872 Common - Rhodanese domain protein Shew185_0320 79 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152998938 Common - 3-isopropylmalate dehydratase, large subunit Shew185_0387 223 COG0065 LeuC, 3-isopropylmalate dehydratase large subunit Amino acid transport and metabolism 153001005 Common - two component transcriptional regulator, LuxR family Shew185_2486 213 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 153002179 Common - tRNA synthetase class II (G H P and S) Shew185_3672 249 COG0441 ThrS, Threonyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153001988 Common - aminopeptidase N Shew185_3479 167 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 153002510 Common - dihydroxy-acid dehydratase Shew185_4007 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 152998815 Common - ThiJ/PfpI domain protein Shew185_0262 117 COG0693 ThiJ, Putative intracellular protease/amidase General function prediction only 153002226 Common - peptidase S9B dipeptidylpeptidase IV domain protein Shew185_3720 112 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 153001000 Common - phosphoenolpyruvate synthase Shew185_2481 235 COG0574 PpsA, Phosphoenolpyruvate synthase/pyruvate phosphate dikinase Carbohydrate transport and metabolism 153001725 Common - multi-sensor hybrid histidine kinase Shew185_3215 213 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152998580 Common - sun protein Shew185_0025 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 153001591 Common - putative HAAAP family transport protein Shew185_3078 32 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 153002624 Common - hypothetical protein Shew185_4125 3 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 153002064 Common - transcriptional regulator, MarR family Shew185_3555 69 COG1846 MarR, Transcriptional regulators Transcription 152999168 Common - MLTD_N domain protein Shew185_0625 108 COG1388 LytE, FOG: LysM repeat Cell envelope biogenesis, outer membrane 153000084 Common - phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I Shew185_1555 241 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 152999794 Common - Oxidoreductase FAD-binding domain protein Shew185_1261 121 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 152999734 Common - general secretion pathway protein B Shew185_1201 8 None None None 152998760 Common - ribosomal protein L24 Shew185_0207 210 COG0198 RplX, Ribosomal protein L24 Translation, ribosomal structure and biogenesis 152998662 Common - peptidase M48 Ste24p Shew185_0109 21 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 153002088 Common - protein of unknown function DUF1696 Shew185_3581 29 None None None 152999402 Common - methylated-DNA--protein-cysteine methyltransferase Shew185_0866 214 COG0350 Ada, Methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 153001790 Common - NusA antitermination factor Shew185_3281 216 COG0195 NusA, Transcription elongation factor Transcription 153002660 Common - protein of unknown function DUF214 Shew185_4162 115 COG2177 FtsX, Cell division protein Cell division and chromosome partitioning 153000172 Common - DEAD/DEAH box helicase domain protein Shew185_1645 241 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 152999837 Common - potassium efflux system protein Shew185_1305 188 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 153001225 Common - Arylesterase Shew185_2709 100 COG2755 TesA, Lysophospholipase L1 and related esterases Amino acid transport and metabolism 153002409 Common - Domain of unknown function DUF1850 Shew185_3903 11 COG4729 COG4729, Uncharacterized conserved protein Function unknown 153001416 Common - dTDP-glucose 4,6-dehydratase Shew185_2900 232 COG1088 RfbB, dTDP-D-glucose 4,6-dehydratase Cell envelope biogenesis, outer membrane 153002402 Common - protein of unknown function zinc metallopeptidase putative Shew185_3896 86 COG2321 COG2321, Predicted metalloprotease General function prediction only 153002874 Common - tRNA modification GTPase TrmE Shew185_4378 229 COG0486 ThdF, Predicted GTPase General function prediction only 153001162 Nonpathogen - hypothetical protein Shew185_2645 1 None None None 153001428 Common - putative CheW protein Shew185_2912 14 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 152999635 Common - diguanylate cyclase Shew185_1101 176 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153000370 Common - GP46 Shew185_1845 7 None None None 153000944 Common - phosphoribosyl-AMP cyclohydrolase Shew185_2425 213 COG0139 HisI, Phosphoribosyl-AMP cyclohydrolase Amino acid transport and metabolism 152998840 Common - integral membrane sensor signal transduction histidine kinase Shew185_0287 219 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153001496 Common - hypothetical protein Shew185_2983 6 None None None 153000957 Common - hypothetical protein Shew185_2438 4 None None None 152999589 Common - hypothetical protein Shew185_1055 1 None None None 153001516 Common - hypothetical protein Shew185_3003 63 COG2976 COG2976, Uncharacterized protein conserved in bacteria Function unknown 153000160 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Shew185_1633 142 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 153002213 Common - hypothetical protein Shew185_3706 2 None None None 153001431 Common - response regulator receiver modulated CheB methylesterase Shew185_2915 196 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 152999450 Common - transcriptional regulator, TetR family Shew185_0914 4 COG1309 AcrR, Transcriptional regulator Transcription 152998767 Common - ribosomal protein L30 Shew185_0214 154 COG1841 RpmD, Ribosomal protein L30/L7E Translation, ribosomal structure and biogenesis 153001843 Common - UDP-glucose 4-epimerase Shew185_3334 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 153001922 Common - ybaK/ebsC protein Shew185_3413 129 COG2606 EbsC, Uncharacterized conserved protein Function unknown 153000201 Common - protein of unknown function DUF748 Shew185_1674 44 None None None 153000130 Common - oligopeptide/dipeptide ABC transporter, ATPase subunit Shew185_1601 249 COG4170 SapD, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 152998593 Common - protein of unknown function UPF0153 Shew185_0038 34 COG0727 COG0727, Predicted Fe-S-cluster oxidoreductase General function prediction only 152998777 Common - CcmE/CycJ protein Shew185_0224 93 COG2332 CcmE, Cytochrome c-type biogenesis protein CcmE Posttranslational modification, protein turnover, chaperones 153000450 Common - protein of unknown function DUF882 Shew185_1925 63 COG3108 COG3108, Uncharacterized protein conserved in bacteria Function unknown 153000680 Common - Aspartate transaminase Shew185_2156 72 COG1448 TyrB, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 153000753 Common - response regulator receiver modulated diguanylate phosphodiesterase Shew185_2232 161 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 153001458 Common - hypothetical protein Shew185_2942 1 None None None 153000282 Common - hypothetical protein Shew185_1757 2 COG1277 NosY, ABC-type transport system involved in multi-copper enzyme maturation, permease component General function prediction only 153000379 Common - transcriptional regulator, XRE family Shew185_1854 5 COG1396 HipB, Predicted transcriptional regulators Transcription 153002753 Common - hypothetical protein Shew185_4255 21 COG0824 FcbC, Predicted thioesterase General function prediction only 153000578 Common - protein of unknown function DUF195 Shew185_2054 153 COG1322 COG1322, Uncharacterized protein conserved in bacteria Function unknown 153001890 Common - hypothetical protein Shew185_3381 4 None None None 152999313 Common - TIM-barrel protein, yjbN family Shew185_0774 208 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 153002424 Common - short-chain dehydrogenase/reductase SDR Shew185_3918 237 COG0300 DltE, Short-chain dehydrogenases of various substrate specificities General function prediction only 153000505 Common - GTPase subunit of restriction endonuclease-like protein Shew185_1980 40 COG1401 McrB, GTPase subunit of restriction endonuclease Defense mechanisms 153001121 Common - conserved hypothetical ATP-dependent protease Shew185_2604 103 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 153000213 Nonpathogen - hypothetical protein Shew185_1687 2 None None None 153002526 Common - putative AcnD-accessory protein PrpF Shew185_4024 55 COG2828 COG2828, Uncharacterized protein conserved in bacteria Function unknown 152999695 Common - hypothetical protein Shew185_1161 2 None None None 153001327 Common - pseudouridine synthase Shew185_2811 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 153001097 Common - hypothetical protein Shew185_2580 4 None None None 153002802 Common - hypothetical protein Shew185_4306 11 COG1571 COG1571, Predicted DNA-binding protein containing a Zn-ribbon domain General function prediction only 152999982 Common - phosphatidate cytidylyltransferase Shew185_1450 214 COG0575 CdsA, CDP-diglyceride synthetase Lipid metabolism 153000066 Common - phosphate uptake regulator, PhoU Shew185_1536 190 COG0704 PhoU, Phosphate uptake regulator Inorganic ion transport and metabolism 153001650 Common - CTP synthase Shew185_3137 246 COG0504 PyrG, CTP synthase (UTP-ammonia lyase) Nucleotide transport and metabolism 153001834 Common - ribosomal-protein-alanine acetyltransferase Shew185_3325 113 COG0456 RimI, Acetyltransferases General function prediction only 153001978 Common - hypothetical protein Shew185_3469 10 None None None 153000586 Common - electron transport complex, RnfABCDGE type, D subunit Shew185_2062 76 COG4658 RnfD, Predicted NADH:ubiquinone oxidoreductase, subunit RnfD Energy production and conversion 153000861 Common - putative prophage repressor Shew185_2341 112 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 152998619 Common - PfkB domain protein Shew185_0064 169 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 152999816 Common - putative transmembrane protein Shew185_1284 6 None None None 152999202 Common - diguanylate cyclase with PAS/PAC sensor Shew185_0662 181 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153000981 Common - Leucyltransferase Shew185_2462 134 COG2360 Aat, Leu/Phe-tRNA-protein transferase Posttranslational modification, protein turnover, chaperones 153002835 Common - transcriptional regulator, TetR family Shew185_4339 41 COG1309 AcrR, Transcriptional regulator Transcription 153000528 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Shew185_2003 197 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 153002143 Common - phosphoesterase PA-phosphatase related Shew185_3636 22 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 153000166 Common - nuclease SbcCD, D subunit Shew185_1639 131 COG0420 SbcD, DNA repair exonuclease DNA replication, recombination, and repair 152999725 Common - putative metalloendopeptidase, glycoprotease family Shew185_1192 249 COG0533 QRI7, Metal-dependent proteases with possible chaperone activity Posttranslational modification, protein turnover, chaperones 153001940 Common - protein of unknown function DUF539 Shew185_3431 1 COG2991 COG2991, Uncharacterized protein conserved in bacteria Function unknown 153001947 Common - NADH:ubiquinone oxidoreductase, subunit A Shew185_3438 40 COG1726 NqrA, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA Energy production and conversion 153002316 Common - diguanylate cyclase/phosphodiesterase Shew185_3810 164 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 153002479 Common - Frataxin family protein Shew185_3976 43 COG1965 CyaY, Protein implicated in iron transport, frataxin homolog Inorganic ion transport and metabolism 152999989 Common - acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase Shew185_1457 164 COG1043 LpxA, Acyl- acyl carrier protein 153001645 Common - tRNA pseudouridine synthase D TruD Shew185_3132 85 COG0585 COG0585, Uncharacterized conserved protein Function unknown 153001577 Common - protein of unknown function DUF1365 Shew185_3064 63 COG3496 COG3496, Uncharacterized conserved protein Function unknown 152999842 Common - hypothetical protein Shew185_1310 2 None None None 153001548 Common - Holliday junction resolvase YqgF Shew185_3035 177 COG0816 COG0816, Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) DNA replication, recombination, and repair 153002777 Common - secretion protein HlyD family protein Shew185_4281 157 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 153002768 Common - transcriptional regulator, XRE family Shew185_4271 30 COG1476 COG1476, Predicted transcriptional regulators Transcription 153000123 Common - ATP-dependent Clp protease, ATP-binding subunit ClpX Shew185_1594 237 COG1219 ClpX, ATP-dependent protease Clp, ATPase subunit Posttranslational modification, protein turnover, chaperones 153000848 Common - hypothetical protein Shew185_2328 6 COG2384 COG2384, Predicted SAM-dependent methyltransferase General function prediction only 153002351 Common - large conductance mechanosensitive channel protein Shew185_3845 118 COG1970 MscL, Large-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 152999622 Common - ATPase AAA-2 domain protein Shew185_1088 218 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 153002709 Common - Propeptide PepSY amd peptidase M4 Shew185_4211 3 COG3212 COG3212, Predicted membrane protein Function unknown 153000150 Common - TonB-dependent receptor Shew185_1621 115 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 153000365 Common - transposase IS3/IS911 family protein Shew185_1840 147 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 153002687 Common - electron transport protein SCO1/SenC Shew185_4189 104 COG1999 COG1999, Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems General function prediction only 153002304 Common - periplasmic solute binding protein Shew185_3798 85 COG0803 LraI, ABC-type metal ion transport system, periplasmic component/surface adhesin Inorganic ion transport and metabolism 153000426 Common - phenylalanyl-tRNA synthetase, beta subunit Shew185_1901 245 COG0072 PheT, Phenylalanyl-tRNA synthetase beta subunit Translation, ribosomal structure and biogenesis 152999869 Common - protein of unknown function DUF162 Shew185_1337 95 COG1139 COG1139, Uncharacterized conserved protein containing a ferredoxin-like domain Energy production and conversion 153001368 Common - 3-oxoacid CoA-transferase, B subunit Shew185_2852 93 COG2057 AtoA, Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit Lipid metabolism 152999121 Common - hypothetical protein Shew185_0574 4 None None None 152998907 Common - hypothetical protein Shew185_0355 8 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 153001131 Common - conserved hypothetical protein 103 Shew185_2614 175 COG0718 COG0718, Uncharacterized protein conserved in bacteria Function unknown 153002470 Common - Hemerythrin HHE cation binding domain protein Shew185_3967 47 COG2846 COG2846, Regulator of cell morphogenesis and NO signaling Cell division and chromosome partitioning 153002785 Common - acriflavin resistance protein Shew185_4289 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 152999531 Common - hypothetical protein Shew185_0997 1 None None None 153001265 Common - protein of unknown function DUF182 Shew185_2749 98 COG1975 XdhC, Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family Posttranslational modification, protein turnover, chaperones 152998773 Common - ribosomal protein S4 Shew185_0220 220 COG0522 RpsD, Ribosomal protein S4 and related proteins Translation, ribosomal structure and biogenesis 152999977 Common - ribosomal protein S2 Shew185_1445 223 COG0052 RpsB, Ribosomal protein S2 Translation, ribosomal structure and biogenesis 153000834 Common - response regulator receiver protein Shew185_2314 1 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 153002811 Common - integral membrane sensor signal transduction histidine kinase Shew185_4315 221 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153000159 Common - protein of unknown function DUF885 Shew185_1632 43 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 153001971 Common - hypothetical protein Shew185_3462 4 None None None 152998729 Common - tRNA (uracil-5-)-methyltransferase Shew185_0176 167 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 152999111 Common - hypothetical protein Shew185_0561 5 None None None 153000264 Common - Tol-Pal system TolQ Shew185_1739 151 COG0811 TolQ, Biopolymer transport proteins Intracellular trafficking and secretion 153002710 Common - two component transcriptional regulator, winged helix family Shew185_4212 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152998780 Common - heme exporter protein CcmB Shew185_0227 94 COG2386 CcmB, ABC-type transport system involved in cytochrome c biogenesis, permease component Posttranslational modification, protein turnover, chaperones 152999025 Common - primosomal protein N' Shew185_0475 213 COG1198 PriA, Primosomal protein N' (replication factor Y) - superfamily II helicase DNA replication, recombination, and repair 153000826 Common - protein of unknown function DUF28 Shew185_2306 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 152999059 Common - amino acid permease-associated region Shew185_0509 173 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 153001868 Common - hypothetical protein Shew185_3359 4 COG4409 NanH, Neuraminidase (sialidase) Carbohydrate transport and metabolism 153000520 Nonpathogen - hypothetical protein Shew185_1995 5 None None None 153002058 Common - sodium:dicarboxylate symporter Shew185_3549 165 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 152999075 Nonpathogen - hypothetical protein Shew185_0525 7 None None None 153002340 Common - regulatory protein ArsR Shew185_3834 166 COG0640 ArsR, Predicted transcriptional regulators Transcription 152998981 Common - hypothetical protein Shew185_0431 14 None None None 153002680 Common - cytochrome c oxidase assembly protein CtaG/Cox11 Shew185_4182 68 COG3175 COX11, Cytochrome oxidase assembly factor Posttranslational modification, protein turnover, chaperones 152999932 Common - tryptophan halogenase Shew185_1400 16 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 153001343 Common - integral membrane sensor signal transduction histidine kinase Shew185_2827 222 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153000470 Common - peptidase S9 prolyl oligopeptidase active site domain protein Shew185_1945 111 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 153000569 Common - GCN5-related N-acetyltransferase Shew185_2045 21 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 153001213 Common - transposase IS116/IS110/IS902 family protein Shew185_2696 98 COG3547 COG3547, Transposase and inactivated derivatives DNA replication, recombination, and repair 153001605 Common - peptidylprolyl isomerase FKBP-type Shew185_3092 140 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 153001244 Common - hypothetical protein Shew185_2728 1 None None None 153001570 Common - hypothetical protein Shew185_3057 1 None None None 152999499 Common - transcriptional regulator, LysR family Shew185_0964 144 COG0583 LysR, Transcriptional regulator Transcription 153001478 Common - SAF domain protein Shew185_2965 32 COG1261 FlgA, Flagellar basal body P-ring biosynthesis protein Cell motility and secretion / Posttranslational modification, protein turnover, chaperones 152999194 Common - ABC transporter related Shew185_0654 248 COG1119 ModF, ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA Inorganic ion transport and metabolism 153001361 Common - putative transcriptional regulator, MerR family Shew185_2845 55 COG0789 SoxR, Predicted transcriptional regulators Transcription 153000729 Common - DsrH family protein Shew185_2208 9 COG2168 DsrH, Uncharacterized conserved protein involved in oxidation of intracellular sulfur Inorganic ion transport and metabolism 153000843 Common - thiamine biosynthesis protein ThiC Shew185_2323 190 COG0422 ThiC, Thiamine biosynthesis protein ThiC Coenzyme metabolism 152998743 Common - DNA-directed RNA polymerase, beta' subunit Shew185_0190 249 COG0086 RpoC, DNA-directed RNA polymerase, beta' subunit/160 kD subunit Transcription 153001290 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Shew185_2774 191 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 153002734 Nonpathogen - hypothetical protein Shew185_4236 1 None None None 153000722 Common - alpha-N-arabinofuranosidase Shew185_2200 3 None None None 153000779 Common - hypothetical protein Shew185_2259 7 None None None 152999529 Common - dihydroorotase, homodimeric type Shew185_0995 88 COG0418 PyrC, Dihydroorotase Nucleotide transport and metabolism 153002702 Common - response regulator receiver modulated diguanylate cyclase Shew185_4204 222 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152999601 Common - cysteine synthase B Shew185_1067 226 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 153001083 Common - Cobyrinic acid ac-diamide synthase Shew185_2566 215 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 153000663 Common - translation elongation factor P Shew185_2139 216 COG0231 Efp, Translation elongation factor P (EF-P)/translation initiation factor 5A (eIF-5A) Translation, ribosomal structure and biogenesis 152999211 Nonpathogen - hypothetical protein Shew185_0671 1 None None None 152998720 Common - NUDIX hydrolase Shew185_0167 137 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 152998753 Common - ribosomal protein S19 Shew185_0200 246 COG0185 RpsS, Ribosomal protein S19 Translation, ribosomal structure and biogenesis 152999030 Common - conserved hypothetical biogenesis protein MshI Shew185_0480 13 None None None 153000924 Common - glycoside hydrolase family 3 domain protein Shew185_2405 169 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 152998609 Common - signal transduction histidine kinase, LytS Shew185_0054 105 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 153002247 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Shew185_3741 140 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 153001897 Common - protein of unknown function DUF808 Shew185_3388 60 COG2354 COG2354, Uncharacterized protein conserved in bacteria Function unknown 152999290 Nonpathogen - hypothetical protein Shew185_0751 1 None None None 152999572 Common - GTP-binding protein Obg/CgtA Shew185_1038 249 COG0536 Obg, Predicted GTPase General function prediction only 152998685 Common - Ferroxidase Shew185_0132 84 COG1528 Ftn, Ferritin-like protein Inorganic ion transport and metabolism 153001951 Common - BolA family protein Shew185_3442 91 COG0271 BolA, Stress-induced morphogen (activity unknown) Signal transduction mechanisms 153002724 Common - hypothetical protein Shew185_4226 1 None None None 153000301 Common - glutaredoxin-like protein Shew185_1776 126 COG0278 COG0278, Glutaredoxin-related protein Posttranslational modification, protein turnover, chaperones 152998599 Common - Rhodanese domain protein Shew185_0044 145 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 153001237 Common - PHP domain protein Shew185_2721 134 COG0613 COG0613, Predicted metal-dependent phosphoesterases (PHP family) General function prediction only 152998616 Common - Sucrose phosphorylase Shew185_0061 71 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 153001911 Common - Dihydrodipicolinate reductase Shew185_3402 217 COG0289 DapB, Dihydrodipicolinate reductase Amino acid transport and metabolism 152999176 Common - Aldose 1-epimerase Shew185_0633 93 COG2017 GalM, Galactose mutarotase and related enzymes Carbohydrate transport and metabolism 153001028 Common - succinate dehydrogenase and fumarate reductase iron-sulfur protein Shew185_2509 199 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 152999068 Common - protein of unknown function DUF541 Shew185_0518 88 COG2968 COG2968, Uncharacterized conserved protein Function unknown 152999618 Common - methyl-accepting chemotaxis sensory transducer Shew185_1084 149 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153002043 Common - transcriptional regulator, CadC Shew185_3534 1 COG3710 CadC, DNA-binding winged-HTH domains Transcription 153002105 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Shew185_3598 191 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 153002571 Common - phosphoheptose isomerase Shew185_4071 123 COG0279 GmhA, Phosphoheptose isomerase Carbohydrate transport and metabolism 153001398 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Shew185_2882 167 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 152999137 Nonpathogen - hypothetical protein Shew185_0593 1 None None None 153001310 Common - efflux transporter, RND family, MFP subunit Shew185_2794 162 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153000105 Common - outer membrane protein precursor MtrB Shew185_1576 9 None None None 152998959 Common - peptidase M23B Shew185_0408 188 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 153002447 Common - Prepilin peptidase Shew185_3944 143 COG1989 PulO, Type II secretory pathway, prepilin signal peptidase PulO and related peptidases Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 152999228 Common - protein of unknown function DUF1239 Shew185_0689 38 COG3117 COG3117, Uncharacterized protein conserved in bacteria Function unknown 153000812 Common - ferredoxin Shew185_2292 45 COG0633 Fdx, Ferredoxin Energy production and conversion 153001308 Common - hypothetical protein Shew185_2792 22 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 153000075 Common - 3-Oxoacyl-(acyl-carrier-protein (ACP)) synthase III domain protein Shew185_1546 184 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 153001384 Common - amidohydrolase Shew185_2868 43 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 153002673 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Shew185_4175 41 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 153001435 Common - RNA polymerase, sigma 28 subunit, FliA/WhiG Shew185_2919 216 COG1191 FliA, DNA-directed RNA polymerase specialized sigma subunit Transcription 152998952 Common - UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase Shew185_0401 208 COG0707 MurG, UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase Cell envelope biogenesis, outer membrane 153002325 Common - alpha-L-glutamate ligase, RimK family Shew185_3819 143 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 152999423 Common - hypothetical protein Shew185_0887 4 None None None 153002232 Nonpathogen - hypothetical protein Shew185_3726 1 None None None 153002451 Common - mutator MutT protein Shew185_3948 169 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 153000211 Nonpathogen - hypothetical protein Shew185_1685 1 None None None 152999517 Common - hypothetical protein Shew185_0982 25 COG3673 COG3673, Uncharacterized conserved protein Function unknown 153002139 Common - putative manganese transporter Shew185_3632 23 COG1914 MntH, Mn2+ and Fe2+ transporters of the NRAMP family Inorganic ion transport and metabolism 152999608 Common - hypothetical protein Shew185_1074 1 None None None 153001076 Nonpathogen - hypothetical protein Shew185_2559 1 None None None 153000537 Common - Methyltransferase type 11 Shew185_2012 55 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152999335 Common - molybdate ABC transporter, ATPase subunit Shew185_0796 249 COG4148 ModC, ABC-type molybdate transport system, ATPase component Inorganic ion transport and metabolism 152999542 Common - hypothetical protein Shew185_1008 13 None None None 153001694 Common - transcriptional regulator, TetR family Shew185_3182 90 COG1309 AcrR, Transcriptional regulator Transcription 153000115 Common - protein of unknown function DUF1282 Shew185_1586 24 None None None 152999652 Common - ribosomal protein S20 Shew185_1118 213 COG0268 RpsT, Ribosomal protein S20 Translation, ribosomal structure and biogenesis 153002130 Common - pseudouridine synthase Shew185_3623 201 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 153001723 Common - trimethylamine-N-oxide reductase TorA Shew185_3213 157 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 153001993 Common - phosphate transporter Shew185_3484 155 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 153000935 Common - GCN5-related N-acetyltransferase Shew185_2416 15 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 153001194 Common - metal dependent phosphohydrolase Shew185_2677 120 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 152999799 Common - cytochrome B561 Shew185_1266 49 COG3658 COG3658, Cytochrome b Energy production and conversion 152998614 Common - major facilitator superfamily MFS_1 Shew185_0059 174 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153001976 Common - protein of unknown function UPF0016 Shew185_3467 76 COG2119 COG2119, Predicted membrane protein Function unknown 152998567 Common - hypothetical protein Shew185_0012 9 COG2258 COG2258, Uncharacterized protein conserved in bacteria Function unknown 153001331 Common - sodium:dicarboxylate symporter Shew185_2815 157 COG3633 SstT, Na+/serine symporter Amino acid transport and metabolism 153001615 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Shew185_3102 80 COG1225 Bcp, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 153002871 Common - methyltransferase GidB Shew185_4375 199 COG0357 GidB, Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division Cell envelope biogenesis, outer membrane 153000249 Common - TonB-dependent siderophore receptor Shew185_1724 123 COG4773 FhuE, Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid Inorganic ion transport and metabolism 152999343 Common - hypothetical protein Shew185_0804 4 None None None 152999096 Common - hypothetical protein Shew185_0546 1 None None None 152999853 Common - 1,4-alpha-glucan branching enzyme Shew185_1321 146 COG0296 GlgB, 1,4-alpha-glucan branching enzyme Carbohydrate transport and metabolism 153001189 Common - putative signal-transduction protein with CBS domains Shew185_2672 170 COG2905 COG2905, Predicted signal-transduction protein containing cAMP-binding and CBS domains Signal transduction mechanisms 153001137 Common - protein of unknown function DUF692 Shew185_2620 62 COG3220 COG3220, Uncharacterized protein conserved in bacteria Function unknown 153000439 Common - nickel-dependent hydrogenase large subunit Shew185_1914 105 COG0374 HyaB, Ni,Fe-hydrogenase I large subunit Energy production and conversion 153002077 Common - two component transcriptional regulator, winged helix family Shew185_3569 216 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152999435 Common - protein of unknown function DUF583 Shew185_0899 19 COG1664 CcmA, Integral membrane protein CcmA involved in cell shape determination Cell envelope biogenesis, outer membrane 152999556 Common - protein of unknown function DUF1008 Shew185_1022 18 COG3721 HugX, Putative heme iron utilization protein Inorganic ion transport and metabolism 153000985 Common - ATP-dependent Clp protease adaptor protein ClpS Shew185_2466 118 COG2127 COG2127, Uncharacterized conserved protein Function unknown 153002629 Common - peptidase M16 domain protein Shew185_4130 201 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 152998942 Common - hypothetical protein Shew185_0391 1 None None None 153002155 Common - ribokinase Shew185_3648 183 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 153000237 Common - ribosomal protein L32 Shew185_1712 66 COG0333 RpmF, Ribosomal protein L32 Translation, ribosomal structure and biogenesis 153001275 Common - tRNA pseudouridine synthase A Shew185_2759 236 COG0101 TruA, Pseudouridylate synthase Translation, ribosomal structure and biogenesis 153002619 Common - TonB-dependent receptor Shew185_4120 131 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 152999070 Nonpathogen - hypothetical protein Shew185_0520 1 None None None 153000591 Common - putative phage repressor Shew185_2067 55 COG2932 COG2932, Predicted transcriptional regulator Transcription 153002536 Common - aminoglycoside phosphotransferase Shew185_4036 52 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 152999055 Common - outer membrane efflux protein Shew185_0505 50 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 152998890 Common - hypothetical protein Shew185_0338 25 COG4648 COG4648, Predicted membrane protein Function unknown 152998601 Common - Glycerol-3-phosphate dehydrogenase (NAD(P)(+)) Shew185_0046 212 COG0240 GpsA, Glycerol-3-phosphate dehydrogenase Energy production and conversion 152999884 Common - protein of unknown function DUF423 Shew185_1352 38 COG2363 COG2363, Uncharacterized small membrane protein Function unknown 153001889 Nonpathogen - hypothetical protein Shew185_3380 1 None None None 153001048 Common - sulfatase Shew185_2529 33 COG3083 COG3083, Predicted hydrolase of alkaline phosphatase superfamily General function prediction only 153001552 Common - twitching motility protein Shew185_3039 212 COG2805 PilT, Tfp pilus assembly protein, pilus retraction ATPase PilT Cell motility and secretion / Intracellular trafficking and secretion 152999033 Common - MSHA biogenesis protein MshK Shew185_0483 1 None None None 153001771 Common - putative phage repressor Shew185_3262 32 COG2932 COG2932, Predicted transcriptional regulator Transcription 153002379 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Shew185_3873 165 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153000475 Common - methyl-accepting chemotaxis sensory transducer Shew185_1950 152 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152999993 Common - tRNA(Ile)-lysidine synthetase Shew185_1461 213 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 152999272 Common - hypothetical protein Shew185_0733 1 None None None 152998803 Common - Catalase Shew185_0250 126 COG0753 KatE, Catalase Inorganic ion transport and metabolism 153000762 Common - response regulator receiver modulated CheB methylesterase Shew185_2242 210 COG2201 CheB, Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain Cell motility and secretion / Signal transduction mechanisms 152999510 Common - ABC transporter related Shew185_0975 249 COG1120 FepC, ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components Inorganic ion transport and metabolism / Coenzyme metabolism 152999490 Common - LrgB family protein Shew185_0955 84 COG1346 LrgB, Putative effector of murein hydrolase Cell envelope biogenesis, outer membrane 152999283 Common - replication P family protein Shew185_0744 8 None None None 153002097 Common - hypoxanthine phosphoribosyltransferase Shew185_3590 151 COG0634 Hpt, Hypoxanthine-guanine phosphoribosyltransferase Nucleotide transport and metabolism 153000689 Common - heavy metal translocating P-type ATPase Shew185_2165 232 COG2217 ZntA, Cation transport ATPase Inorganic ion transport and metabolism 152999583 Common - Organic solvent tolerance protein Shew185_1049 119 COG1452 Imp, Organic solvent tolerance protein OstA Cell envelope biogenesis, outer membrane 152999079 Common - Activator of Hsp90 ATPase 1 family protein Shew185_0529 63 COG3832 COG3832, Uncharacterized conserved protein Function unknown 153001828 Common - lytic murein transglycosylase B Shew185_3319 102 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 153000242 Common - acyl carrier protein Shew185_1717 176 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153000555 Common - thiamine pyrophosphate protein domain protein TPP-binding Shew185_2031 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 153002748 Common - transporter, hydrophobe/amphiphile efflux-1 (HAE1) family Shew185_4250 180 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 153002259 Common - Arginine N-succinyltransferase Shew185_3753 37 COG3138 AstA, Arginine/ornithine N-succinyltransferase beta subunit Amino acid transport and metabolism 153002658 Common - O-succinylbenzoate-CoA ligase Shew185_4160 219 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152999267 Common - GP46 Shew185_0728 7 None None None 153002016 Common - dienelactone hydrolase Shew185_3507 50 COG0412 COG0412, Dienelactone hydrolase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 153000656 Common - 6-phosphogluconate dehydratase Shew185_2132 210 COG0129 IlvD, Dihydroxyacid dehydratase/phosphogluconate dehydratase Amino acid transport and metabolism / Carbohydrate transport and metabolism 153000006 Common - transcriptional regulator, LysR family Shew185_1474 53 COG0583 LysR, Transcriptional regulator Transcription 152998631 Common - MORN variant repeat protein Shew185_0076 16 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 153001128 Common - hypothetical protein Shew185_2611 3 None None None 153002601 Common - hypothetical protein Shew185_4102 14 None None None 152999727 Common - dihydroneopterin aldolase Shew185_1194 116 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 153000917 Common - acylphosphatase Shew185_2397 98 COG1254 AcyP, Acylphosphatases Energy production and conversion 152999926 Common - Rhodanese domain protein Shew185_1394 85 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 153001260 Common - methyl-accepting chemotaxis sensory transducer Shew185_2744 146 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152999130 Common - putative two component transcriptional regulator, winged helix family Shew185_0586 2 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153000871 Common - PTS system, glucose subfamily, IIA subunit Shew185_2351 60 COG2190 NagE, Phosphotransferase system IIA components Carbohydrate transport and metabolism 153001454 Common - two component, sigma54 specific, transcriptional regulator, Fis family Shew185_2938 224 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153001661 Common - hypothetical protein Shew185_3148 1 None None None 153000391 Nonpathogen - hypothetical protein Shew185_1866 1 COG4969 PilA, Tfp pilus assembly protein, major pilin PilA Cell motility and secretion / Intracellular trafficking and secretion 153000712 Nonpathogen - hypothetical protein Shew185_2190 1 None None None 152999745 Common - protein of unknown function UPF0075 Shew185_1212 120 COG2377 COG2377, Predicted molecular chaperone distantly related to HSP70-fold metalloproteases Posttranslational modification, protein turnover, chaperones 152998856 Common - histidine kinase Shew185_0304 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153000039 Common - hypothetical protein Shew185_1509 1 None None None 153001112 Common - HtpX domain protein Shew185_2595 191 COG0501 HtpX, Zn-dependent protease with chaperone function Posttranslational modification, protein turnover, chaperones 153001933 Common - methyl-accepting chemotaxis sensory transducer Shew185_3424 147 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153002584 Common - type IV pilus secretin PilQ Shew185_4085 142 COG4796 HofQ, Type II secretory pathway, component HofQ Intracellular trafficking and secretion 153002863 Common - ATP synthase F1, alpha subunit Shew185_4367 247 COG0056 AtpA, F0F1-type ATP synthase, alpha subunit Energy production and conversion 153002413 Common - anion transporter Shew185_3907 170 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 152999015 Common - Diaminopimelate decarboxylase Shew185_0465 213 COG0019 LysA, Diaminopimelate decarboxylase Amino acid transport and metabolism 152998869 Common - D-tyrosyl-tRNA(Tyr) deacylase Shew185_0317 139 COG1490 Dtd, D-Tyr-tRNAtyr deacylase Translation, ribosomal structure and biogenesis 153001182 Common - 2',3'-cyclic-nucleotide 2'-phosphodiesterase Shew185_2665 112 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 152999509 Common - Phosphoglycerate mutase Shew185_0974 92 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 152999368 Common - protein of unknown function DUF214 Shew185_0832 45 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 153000256 Common - uracil phosphoribosyltransferase Shew185_1731 164 COG0035 Upp, Uracil phosphoribosyltransferase Nucleotide transport and metabolism 153000222 Common - conserved hypothetical protein CHP02464 Shew185_1696 30 COG3236 COG3236, Uncharacterized protein conserved in bacteria Function unknown 152999381 Common - 3-methyl-2-oxobutanoate hydroxymethyltransferase Shew185_0845 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 153002565 Common - hypothetical protein Shew185_4065 1 None None None 153000389 Common - hypothetical protein Shew185_1864 3 None None None 152999549 Common - ABC transporter related Shew185_1015 249 COG4559 COG4559, ABC-type hemin transport system, ATPase component Inorganic ion transport and metabolism 153001491 Common - UDP-N-acetylglucosamine 2-epimerase Shew185_2978 83 COG0381 WecB, UDP-N-acetylglucosamine 2-epimerase Cell envelope biogenesis, outer membrane 152998821 Common - 2OG-Fe(II) oxygenase Shew185_0268 21 None None None 152998924 Common - transcriptional regulator, TetR family Shew185_0373 60 COG1309 AcrR, Transcriptional regulator Transcription 152999061 Common - protein of unknown function DUF615 Shew185_0511 60 COG3028 COG3028, Uncharacterized protein conserved in bacteria Function unknown 152998919 Common - YicC domain protein Shew185_0367 137 COG1561 COG1561, Uncharacterized stress-induced protein Function unknown 152998571 Common - fatty oxidation complex, alpha subunit FadB Shew185_0016 189 COG1250 FadB, 3-hydroxyacyl-CoA dehydrogenase Lipid metabolism 153002878 Common - ribosomal protein L34 Shew185_4382 12 None None None 153001546 Common - translation initiation factor SUI1 Shew185_3033 77 COG0023 SUI1, Translation initiation factor 1 (eIF-1/SUI1) and related proteins Translation, ribosomal structure and biogenesis 153000088 Common - Aerolysin/hemolysin/leukocidin toxin Shew185_1559 5 None None None 152999305 Nonpathogen - hypothetical protein Shew185_0766 1 None None None 153000967 Common - putative RNA methylase, NOL1/NOP2/sun family Shew185_2448 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 153002699 Common - sulfatase Shew185_4201 72 COG1368 MdoB, Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily Cell envelope biogenesis, outer membrane 153002606 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Shew185_4107 179 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153001629 Common - RDD domain containing protein Shew185_3116 22 COG1714 COG1714, Predicted membrane protein/domain Function unknown 153001882 Nonpathogen - hypothetical protein Shew185_3373 2 None None None 153002497 Common - protein of unknown function DUF1006 Shew185_3994 61 COG3214 COG3214, Uncharacterized protein conserved in bacteria Function unknown 153002669 Common - hypothetical protein Shew185_4171 23 None None None 153002000 Common - lysyl-tRNA synthetase Shew185_3491 249 COG1190 LysU, Lysyl-tRNA synthetase (class II) Translation, ribosomal structure and biogenesis 153001196 Common - DNA ligase, NAD-dependent Shew185_2679 219 COG0272 Lig, NAD-dependent DNA ligase (contains BRCT domain type II) DNA replication, recombination, and repair 153000495 Common - putative replication protein Shew185_1970 13 None None None 153000693 Common - cytochrome c oxidase, cbb3-type, subunit II Shew185_2169 82 COG2993 CcoO, Cbb3-type cytochrome oxidase, cytochrome c subunit Energy production and conversion 153001778 Nonpathogen - hypothetical protein Shew185_3269 1 None None None 152999750 Common - protein of unknown function UPF0126 Shew185_1217 133 COG2860 COG2860, Predicted membrane protein Function unknown 152999358 Common - hypothetical protein Shew185_0822 1 None None None 153000432 Common - hydrogenase assembly chaperone hypC/hupF Shew185_1907 82 COG0298 HypC, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 153002090 Common - pseudouridine synthase Shew185_3583 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 153001419 Common - polysaccharide export protein Shew185_2903 100 COG1596 Wza, Periplasmic protein involved in polysaccharide export Cell envelope biogenesis, outer membrane 153002034 Common - branched-chain amino acid transport system II carrier protein Shew185_3525 49 COG1114 BrnQ, Branched-chain amino acid permeases Amino acid transport and metabolism 152998696 Common - hypothetical protein Shew185_0143 36 COG1289 COG1289, Predicted membrane protein Function unknown 153002486 Common - ABC transporter related Shew185_3983 249 COG2274 SunT, ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain Defense mechanisms 152999012 Common - Sel1 domain protein repeat-containing protein Shew185_0462 93 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 152998833 Common - molybdopterin biosynthesis MoaE protein Shew185_0280 158 COG0314 MoaE, Molybdopterin converting factor, large subunit Coenzyme metabolism 152999792 Common - chorismate mutase Shew185_1259 79 COG0287 TyrA, Prephenate dehydrogenase Amino acid transport and metabolism 152999943 Common - diacylglycerol kinase catalytic region Shew185_1411 69 COG1597 LCB5, Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase Lipid metabolism / General function prediction only 153000808 Common - ubiquinone biosynthesis O-methyltransferase Shew185_2288 156 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 153002332 Common - amino acid carrier protein Shew185_3826 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 153002074 Common - MltA-interacting MipA family protein Shew185_3566 32 COG3713 OmpV, Outer membrane protein V Cell envelope biogenesis, outer membrane 152999956 Common - transcriptional regulator, LysR family Shew185_1424 118 COG0583 LysR, Transcriptional regulator Transcription 153001678 Common - hypothetical protein Shew185_3166 10 COG3631 COG3631, Ketosteroid isomerase-related protein General function prediction only 152999717 Common - Beta-glucosidase Shew185_1183 103 COG2723 BglB, Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase Carbohydrate transport and metabolism 153002803 Nonpathogen - hypothetical protein Shew185_4307 2 None None None 152999319 Common - hypothetical protein Shew185_0780 17 None None None 153000413 Common - hypothetical protein Shew185_1888 6 None None None 152999714 Common - TonB-dependent receptor plug Shew185_1180 43 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 153000775 Common - Prolyl oligopeptidase Shew185_2255 113 COG1505 COG1505, Serine proteases of the peptidase family S9A Amino acid transport and metabolism 153002343 Common - isochorismatase hydrolase Shew185_3837 141 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 153001633 Common - DNA polymerase III chi subunit HolC Shew185_3120 57 COG2927 HolC, DNA polymerase III, chi subunit DNA replication, recombination, and repair 153001863 Nonpathogen - hypothetical protein Shew185_3354 1 None None None 153000414 Common - hypothetical protein Shew185_1889 21 COG4798 COG4798, Predicted methyltransferase General function prediction only 153002172 Common - hypothetical protein Shew185_3665 4 None None None 153002859 Common - UDP-N-acetylglucosamine pyrophosphorylase Shew185_4363 232 COG1207 GlmU, N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) Cell envelope biogenesis, outer membrane 153002028 Common - hypothetical protein Shew185_3519 1 None None None 152998987 Common - integral membrane sensor signal transduction histidine kinase Shew185_0437 58 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153002852 Common - Cytochrome c oxidase cbb3 type accessory protein FixG Shew185_4356 81 COG0348 NapH, Polyferredoxin Energy production and conversion 152998620 Common - molybdenum cofactor synthesis domain Shew185_0065 189 COG0521 MoaB, Molybdopterin biosynthesis enzymes Coenzyme metabolism 153002008 Common - OsmC family protein Shew185_3499 92 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 153002422 Common - hypothetical protein Shew185_3916 4 None None None 152999597 Common - sulfate ABC transporter, ATPase subunit Shew185_1063 249 COG1118 CysA, ABC-type sulfate/molybdate transport systems, ATPase component Inorganic ion transport and metabolism 153001736 Common - purine nucleoside phosphorylase Shew185_3227 101 COG0813 DeoD, Purine-nucleoside phosphorylase Nucleotide transport and metabolism 152999672 Common - tryptophan halogenase Shew185_1138 16 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 153000703 Nonpathogen - hypothetical protein Shew185_2179 1 None None None 152999661 Common - type IV pilus assembly protein PilX Shew185_1127 1 COG4726 PilX, Tfp pilus assembly protein PilX Cell motility and secretion / Intracellular trafficking and secretion 152998560 Common - Glutathione S-transferase domain Shew185_0005 88 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 152999964 Common - hypothetical protein Shew185_1432 21 COG4323 COG4323, Predicted membrane protein Function unknown 153001231 Common - short-chain dehydrogenase/reductase SDR Shew185_2715 224 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153001068 Common - Disulphide bond formation protein DsbB Shew185_2550 13 COG1495 DsbB, Disulfide bond formation protein DsbB Posttranslational modification, protein turnover, chaperones 153001620 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Shew185_3107 146 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153000143 Common - histone deacetylase superfamily Shew185_1614 156 COG0123 AcuC, Deacetylases, including yeast histone deacetylase and acetoin utilization protein Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism 152999682 Common - glucose/galactose transporter Shew185_1148 59 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 152999005 Common - protein of unknown function DUF1486 Shew185_0455 15 COG5485 COG5485, Predicted ester cyclase General function prediction only 153000156 Common - TonB family protein Shew185_1629 36 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 153001583 Common - Protein of unknown function DUF1722 Shew185_3070 67 COG3272 COG3272, Uncharacterized conserved protein Function unknown 152998874 Common - benzoate transporter Shew185_0322 59 COG3135 BenE, Uncharacterized protein involved in benzoate metabolism Secondary metabolites biosynthesis, transport, and catabolism 152999467 Common - Adenylyl-sulfate kinase Shew185_0931 145 COG0529 CysC, Adenylylsulfate kinase and related kinases Inorganic ion transport and metabolism 153001202 Common - cysteine synthase A Shew185_2685 219 COG0031 CysK, Cysteine synthase Amino acid transport and metabolism 152999088 Common - 5,10-methylenetetrahydrofolate reductase Shew185_0538 144 COG0685 MetF, 5,10-methylenetetrahydrofolate reductase Amino acid transport and metabolism 153001460 Common - flagellar protein FlaG protein Shew185_2944 16 COG1334 FlaG, Uncharacterized flagellar protein FlaG Cell motility and secretion 153002690 Common - HesB/YadR/YfhF-family protein Shew185_4192 79 COG0694 COG0694, Thioredoxin-like proteins and domains Posttranslational modification, protein turnover, chaperones 152999184 Common - efflux transporter, RND family, MFP subunit Shew185_0641 150 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153000286 Common - arginine decarboxylase Shew185_1761 127 COG1166 SpeA, Arginine decarboxylase (spermidine biosynthesis) Amino acid transport and metabolism 152999820 Common - Carotenoid oxygenase Shew185_1288 34 COG3670 COG3670, Lignostilbene-alpha,beta-dioxygenase and related enzymes Secondary metabolites biosynthesis, transport, and catabolism 153000832 Common - gonadoliberin III-related protein Shew185_2312 19 None None None 152998870 Common - thioesterase domain, putative Shew185_0318 33 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 152999876 Common - Polyprenyl synthetase Shew185_1344 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 153000170 Common - protein of unknown function DUF45 Shew185_1643 48 COG1451 COG1451, Predicted metal-dependent hydrolase General function prediction only 153000845 Common - channel protein, hemolysin III family Shew185_2325 119 COG1272 COG1272, Predicted membrane protein, hemolysin III homolog General function prediction only 153001252 Common - YCII-related Shew185_2736 49 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 153000338 Common - putative esterase Shew185_1813 37 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 153001831 Common - protein of unknown function DUF493 Shew185_3322 47 COG2921 COG2921, Uncharacterized conserved protein Function unknown 152999789 Common - tRNA (guanine-N1)-methyltransferase Shew185_1256 215 COG0336 TrmD, tRNA-(guanine-N1)-methyltransferase Translation, ribosomal structure and biogenesis 153001472 Common - flagellar basal body FlaE domain protein Shew185_2959 126 COG1749 FlgE, Flagellar hook protein FlgE Cell motility and secretion 153001840 Common - regulatory protein LacI Shew185_3331 127 COG1609 PurR, Transcriptional regulators Transcription 152998654 Common - formate dehydrogenase, beta subunit Shew185_0101 161 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153001055 Common - hypothetical protein Shew185_2536 16 None None None 153000352 Common - two component transcriptional regulator, winged helix family Shew185_1827 212 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153002165 Common - prolipoprotein diacylglyceryl transferase Shew185_3658 197 COG0682 Lgt, Prolipoprotein diacylglyceryltransferase Cell envelope biogenesis, outer membrane 153002546 Common - hypothetical protein Shew185_4046 9 None None None 152999921 Common - hypothetical protein Shew185_1389 15 None None None 153001094 Common - hypothetical protein Shew185_2577 16 None None None 153001366 Common - pyruvate carboxyltransferase Shew185_2850 202 COG0119 LeuA, Isopropylmalate/homocitrate/citramalate synthases Amino acid transport and metabolism 153001143 Common - Carboxylesterase Shew185_2626 95 COG0400 COG0400, Predicted esterase General function prediction only 153000953 Common - hypothetical protein Shew185_2434 91 COG1033 COG1033, Predicted exporters of the RND superfamily General function prediction only 153000349 Common - CreA family protein Shew185_1824 57 COG3045 CreA, Uncharacterized protein conserved in bacteria Function unknown 153001166 Common - hypothetical protein Shew185_2649 5 None None None 153000692 Common - Cbb3-type cytochrome oxidase component Shew185_2168 16 COG4736 CcoQ, Cbb3-type cytochrome oxidase, subunit 3 Posttranslational modification, protein turnover, chaperones 152999569 Common - Polyprenyl synthetase Shew185_1035 243 COG0142 IspA, Geranylgeranyl pyrophosphate synthase Coenzyme metabolism 152999642 Common - Hemerythrin HHE cation binding domain protein Shew185_1108 15 COG3945 COG3945, Uncharacterized conserved protein Function unknown 153002612 Common - methyl-accepting chemotaxis sensory transducer Shew185_4113 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153001595 Common - protein of unknown function DUF368 Shew185_3082 48 COG2035 COG2035, Predicted membrane protein Function unknown 153001407 Common - glycosyl transferase group 1 Shew185_2891 150 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153000127 Common - TOBE domain protein Shew185_1598 71 COG3585 MopI, Molybdopterin-binding protein Coenzyme metabolism 153002084 Common - Fe-S metabolism associated SufE Shew185_3576 92 COG2166 COG2166, SufE protein probably involved in Fe-S center assembly General function prediction only 153000200 Common - glutaredoxin Shew185_1673 21 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 153002203 Common - oxidoreductase FAD/NAD(P)-binding domain protein Shew185_3696 116 COG1018 Hmp, Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 Energy production and conversion 152999827 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Shew185_1295 193 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 153001508 Common - Lytic transglycosylase catalytic Shew185_2995 98 COG4623 COG4623, Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein Cell envelope biogenesis, outer membrane 153001338 Common - glutamyl-tRNA synthetase Shew185_2822 249 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 153000396 Common - HipA domain protein Shew185_1871 52 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 153002196 Common - Dyp-type peroxidase family Shew185_3689 55 COG2837 COG2837, Predicted iron-dependent peroxidase Inorganic ion transport and metabolism 153000960 Common - ProQ activator of osmoprotectant transporter ProP Shew185_2441 33 COG3109 ProQ, Activator of osmoprotectant transporter ProP Signal transduction mechanisms 153001809 Common - Aminoacyl-tRNA hydrolase Shew185_3300 216 COG0193 Pth, Peptidyl-tRNA hydrolase Translation, ribosomal structure and biogenesis 153002296 Common - SNF2-related protein Shew185_3790 127 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 152999044 Common - MSHA biogenesis protein MshO Shew185_0494 13 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 152998644 Common - glycerophosphoryl diester phosphodiesterase Shew185_0090 163 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 152999765 Common - Thymidylate synthase Shew185_1232 138 COG0207 ThyA, Thymidylate synthase Nucleotide transport and metabolism 153000910 Common - Inositol-phosphate phosphatase Shew185_2390 212 COG0483 SuhB, Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family Carbohydrate transport and metabolism 153002285 Common - glycerophosphoryl diester phosphodiesterase Shew185_3779 149 COG0584 UgpQ, Glycerophosphoryl diester phosphodiesterase Energy production and conversion 153001211 Common - phosphate acetyltransferase Shew185_2694 173 COG0280 Pta, Phosphotransacetylase Energy production and conversion 152999218 Common - OmpA/MotB domain protein Shew185_0679 137 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 152999916 Common - transcriptional regulator, MarR family Shew185_1384 119 COG1846 MarR, Transcriptional regulators Transcription 153001520 Common - type IV pilus biogenesis/stability protein PilW Shew185_3007 91 COG3063 PilF, Tfp pilus assembly protein PilF Cell motility and secretion / Intracellular trafficking and secretion 153001448 Common - flagellar export protein FliJ Shew185_2932 40 COG2882 FliJ, Flagellar biosynthesis chaperone Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones 153001903 Common - Endonuclease/exonuclease/phosphatase Shew185_3394 12 None None None 153002224 Common - hypothetical protein Shew185_3718 4 None None None 153002239 Common - integral membrane sensor signal transduction histidine kinase Shew185_3733 206 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153000468 Common - para-aminobenzoate synthase, subunit I Shew185_1943 223 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 152999578 Common - bis(5'-nucleosyl)-tetraphosphatase (symmetrical) Shew185_1044 90 None None None 153002319 Common - hypothetical protein Shew185_3813 1 None None None 152999351 Common - hypothetical protein Shew185_0812 7 COG2039 Pcp, Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase) Posttranslational modification, protein turnover, chaperones 152999409 Common - ABC transporter CydDC cysteine exporter (CydDC-E) family permease/ATP-binding protein CydD Shew185_0873 249 COG4988 CydD, ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components Energy production and conversion / Posttranslational modification, protein turnover, chaperones 152999441 Common - response regulator receiver Shew185_0905 60 COG4565 CitB, Response regulator of citrate/malate metabolism Transcription / Signal transduction mechanisms 153002809 Common - hypothetical protein Shew185_4313 97 COG1738 COG1738, Uncharacterized conserved protein Function unknown 153001392 Common - Patatin Shew185_2876 46 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 152998660 Common - protein of unknown function DUF395 YeeE/YedE Shew185_0107 30 COG2391 COG2391, Predicted transporter component General function prediction only 153000003 Common - protein of unknown function DUF218 Shew185_1471 58 COG1434 COG1434, Uncharacterized conserved protein Function unknown 152999800 Common - cytochrome c class II Shew185_1267 36 COG3909 COG3909, Cytochrome c556 Energy production and conversion 153002551 Common - PEBP family protein Shew185_4051 121 COG1881 COG1881, Phospholipid-binding protein General function prediction only 152998835 Common - molybdate ABC transporter, inner membrane subunit Shew185_0282 225 COG4149 ModC, ABC-type molybdate transport system, permease component Inorganic ion transport and metabolism 153001532 Common - hypothetical protein Shew185_3019 70 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 152999905 Common - periplasmic/7TM domain sensor diguanylate cyclase Shew185_1373 169 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153002649 Common - putative transcriptional regulator, AsnC family Shew185_4150 131 COG1522 Lrp, Transcriptional regulators Transcription 153002692 Common - hypothetical protein Shew185_4194 1 None None None 153001154 Common - anti-ECFsigma factor, ChrR Shew185_2637 28 COG3806 ChrR, Transcriptional activator Transcription 153000673 Common - 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) Shew185_2149 157 COG1071 AcoA, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit Energy production and conversion 153000620 Common - prophage MuSo1, protein Gp32, putative Shew185_2096 18 COG4388 COG4388, Mu-like prophage I protein General function prediction only 153002548 Common - hypothetical protein Shew185_4048 2 None None None 152998939 Common - 3-isopropylmalate dehydratase, small subunit Shew185_0388 212 COG0066 LeuD, 3-isopropylmalate dehydratase small subunit Amino acid transport and metabolism 152999763 Common - protein of unknown function DUF81 Shew185_1230 60 COG0730 COG0730, Predicted permeases General function prediction only 153001689 Common - hypothetical protein Shew185_3177 14 None None None 153000354 Common - Vault protein inter-alpha-trypsin domain protein Shew185_1829 39 COG2304 COG2304, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 153000627 Common - phage tape measure protein Shew185_2103 51 COG3941 COG3941, Mu-like prophage protein General function prediction only 153000542 Common - sodium/hydrogen exchanger Shew185_2017 101 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 153000048 Common - hypothetical protein Shew185_1518 7 None None None 153001003 Common - glycoside hydrolase family 18 Shew185_2484 65 COG3325 ChiA, Chitinase Carbohydrate transport and metabolism 153000781 Common - hypothetical protein Shew185_2261 3 None None None 152998582 Common - peptide deformylase Shew185_0027 215 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 153002622 Common - transcriptional regulator, LysR family Shew185_4123 92 COG0583 LysR, Transcriptional regulator Transcription 153001518 Common - 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase Shew185_3005 188 COG0821 GcpE, Enzyme involved in the deoxyxylulose pathway of isoprenoid biosynthesis Lipid metabolism 153002799 Common - Paraquat-inducible protein A Shew185_4303 6 COG2995 PqiA, Uncharacterized paraquat-inducible protein A Function unknown 152999104 Common - excinuclease ABC, A subunit Shew185_0554 237 COG0178 UvrA, Excinuclease ATPase subunit DNA replication, recombination, and repair 153001792 Common - preprotein translocase, SecG subunit Shew185_3283 73 COG1314 SecG, Preprotein translocase subunit SecG Intracellular trafficking and secretion 153000942 Common - phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Shew185_2423 214 COG0106 HisA, Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase Amino acid transport and metabolism 153000767 Common - CheA signal transduction histidine kinase Shew185_2247 154 COG0643 CheA, Chemotaxis protein histidine kinase and related kinases Cell motility and secretion / Signal transduction mechanisms 153001899 Common - PUA domain containing protein Shew185_3390 142 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 152998716 Common - hypothetical protein Shew185_0163 8 None None None 152999782 Common - holo-acyl-carrier-protein synthase Shew185_1249 113 COG0736 AcpS, Phosphopantetheinyl transferase (holo-ACP synthase) Lipid metabolism 153001178 Common - Peptidyl-dipeptidase Dcp Shew185_2661 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 153000164 Common - transcriptional regulator, LysR family Shew185_1637 163 COG0583 LysR, Transcriptional regulator Transcription 153000073 Common - protein of unknown function DUF1289 Shew185_1544 10 COG3313 COG3313, Predicted Fe-S protein General function prediction only 153000669 Common - SeqA family protein Shew185_2145 23 COG3057 SeqA, Negative regulator of replication initiationR DNA replication, recombination, and repair 153001759 Common - hypothetical protein Shew185_3250 2 None None None 152998694 Common - Methyltransferase type 12 Shew185_0141 36 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 152999244 Common - Adenylosuccinate synthase Shew185_0705 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 152999732 Common - polynucleotide adenylyltransferase/metal dependent phosphohydrolase Shew185_1199 196 COG0617 PcnB, tRNA nucleotidyltransferase/poly(A) polymerase Translation, ribosomal structure and biogenesis 153002278 Common - carbohydrate kinase, YjeF related protein Shew185_3772 222 COG0063 COG0063, Predicted sugar kinase Carbohydrate transport and metabolism 153001927 Common - hypothetical protein Shew185_3418 3 None None None 152999633 Common - hypothetical protein Shew185_1099 1 None None None 152999699 Common - Glutamate--putrescine ligase Shew185_1165 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 153001035 Common - acriflavin resistance protein Shew185_2516 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 153002066 Nonpathogen - hypothetical protein Shew185_3558 2 None None None 153001593 Common - protein of unknown function DUF1063 Shew185_3080 35 COG3681 COG3681, Uncharacterized conserved protein Function unknown 153000583 Common - endonuclease III Shew185_2059 240 COG0177 Nth, Predicted EndoIII-related endonuclease DNA replication, recombination, and repair 153001550 Common - glutathione peroxidase Shew185_3037 114 COG0386 BtuE, Glutathione peroxidase Posttranslational modification, protein turnover, chaperones 152998932 Common - RarD protein, DMT superfamily transporter Shew185_0381 97 COG2962 RarD, Predicted permeases General function prediction only 153002876 Common - protein of unknown function DUF37 Shew185_4380 186 COG0759 COG0759, Uncharacterized conserved protein Function unknown 153001223 Common - protein of unknown function DUF214 Shew185_2707 86 COG3127 COG3127, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component Secondary metabolites biosynthesis, transport, and catabolism 152998968 Common - 2-polyprenylphenol 6-hydroxylase Shew185_0417 184 COG0661 AarF, Predicted unusual protein kinase General function prediction only 152999659 Common - type IV pilus modification protein PilV Shew185_1125 6 COG4967 PilV, Tfp pilus assembly protein PilV Cell motility and secretion / Intracellular trafficking and secretion 152999809 Common - peptidase S41 Shew185_1276 56 COG4946 COG4946, Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system Function unknown 153000961 Common - putative GAF sensor protein Shew185_2442 81 COG1956 COG1956, GAF domain-containing protein Signal transduction mechanisms 153000086 Common - transcription activator effector binding Shew185_1557 25 COG3708 COG3708, Uncharacterized protein conserved in bacteria Function unknown 153000377 Nonpathogen - hypothetical protein Shew185_1852 1 None None None 153000819 Common - hypothetical protein Shew185_2299 4 None None None 153001920 Common - chaperone protein DnaK Shew185_3411 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 153000807 Common - DNA gyrase, A subunit Shew185_2287 230 COG0188 GyrA, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit DNA replication, recombination, and repair 153001981 Common - Endonuclease/exonuclease/phosphatase Shew185_3472 49 COG2374 COG2374, Predicted extracellular nuclease General function prediction only 153001126 Common - glutaredoxin 2 Shew185_2609 10 None None None 153001266 Common - methyl-accepting chemotaxis sensory transducer Shew185_2750 148 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153002100 Common - hypothetical protein Shew185_3593 4 None None None 153002167 Common - putative outer membrane adhesin like proteiin Shew185_3660 99 COG4245 TerY, Uncharacterized protein encoded in toxicity protection region of plasmid R478, contains von Willebrand factor (vWF) domain General function prediction only 153000810 Common - ribonucleoside-diphosphate reductase, alpha subunit Shew185_2290 212 COG0209 NrdA, Ribonucleotide reductase, alpha subunit Nucleotide transport and metabolism 152999968 Common - pseudouridine synthase Shew185_1436 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 153001357 Common - transcriptional regulator, LysR family Shew185_2841 177 COG0583 LysR, Transcriptional regulator Transcription 153002463 Common - succinate dehydrogenase or fumarate reductase, flavoprotein subunit Shew185_3960 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 153002604 Common - Formate dehydrogenase region TAT target Shew185_4105 1 None None None 152999690 Common - Feruloyl esterase Shew185_1156 20 COG3509 LpqC, Poly(3-hydroxybutyrate) depolymerase Secondary metabolites biosynthesis, transport, and catabolism 153002273 Common - RNA chaperone Hfq Shew185_3767 127 COG1923 Hfq, Uncharacterized host factor I protein General function prediction only 153000902 Common - Fe-S protein assembly chaperone HscA Shew185_2382 235 COG0443 DnaK, Molecular chaperone Posttranslational modification, protein turnover, chaperones 153000662 Common - Glutamate--putrescine ligase Shew185_2138 225 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 152999459 Common - Prolyl 4-hydroxylase alpha subunit Shew185_0923 5 COG3751 EGL-9, Predicted proline hydroxylase Posttranslational modification, protein turnover, chaperones 152999178 Common - sodium/hydrogen exchanger Shew185_0635 166 COG4651 RosB, Kef-type K+ transport system, predicted NAD-binding component Inorganic ion transport and metabolism 153002314 Common - GumN family protein Shew185_3808 41 COG3735 COG3735, Uncharacterized protein conserved in bacteria Function unknown 153001807 Common - hypothetical protein Shew185_3298 2 None None None 153000485 Nonpathogen - hypothetical protein Shew185_1960 1 None None None 152999814 Common - methyl-accepting chemotaxis sensory transducer Shew185_1282 162 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153000442 Common - lipoprotein, putative Shew185_1917 6 None None None 153002215 Common - nitrogen regulatory protein P-II Shew185_3708 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 152999226 Common - ABC transporter related Shew185_0687 249 COG1137 YhbG, ABC-type (unclassified) transport system, ATPase component General function prediction only 153001242 Common - tryptophan synthase, beta subunit Shew185_2726 224 COG0133 TrpB, Tryptophan synthase beta chain Amino acid transport and metabolism 153000186 Common - signal transduction histidine kinase, LytS Shew185_1659 105 COG3275 LytS, Putative regulator of cell autolysis Signal transduction mechanisms 153001709 Common - peptidase U32 Shew185_3197 55 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 152999166 Common - hypothetical protein Shew185_0623 4 None None None 153002560 Common - hypothetical protein Shew185_4060 28 COG3788 COG3788, Uncharacterized relative of glutathione S-transferase, MAPEG superfamily General function prediction only 153000633 Nonpathogen - hypothetical protein Shew185_2109 1 None None None 153000228 Common - hypothetical protein Shew185_1703 1 None None None 153001063 Common - porin Gram-negative type Shew185_2545 18 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 153000651 Common - Protein of unknown function DUF1974 Shew185_2127 150 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 153000562 Common - TonB-dependent receptor Shew185_2038 23 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 153000231 Common - sulphate transporter Shew185_1706 161 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 153002358 Common - hypothetical protein Shew185_3852 2 None None None 152998914 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Shew185_0362 78 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 153002732 Nonpathogen - hypothetical protein Shew185_4234 1 None None None 153000751 Common - integral membrane sensor hybrid histidine kinase Shew185_2230 216 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152998921 Common - orotate phosphoribosyltransferase Shew185_0370 127 COG0461 PyrE, Orotate phosphoribosyltransferase Nucleotide transport and metabolism 153001700 Common - putative CheW protein Shew185_3188 220 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153001527 Common - GCN5-related N-acetyltransferase Shew185_3014 37 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 152999481 Nonpathogen - hypothetical protein Shew185_0946 1 None None None 152999086 Common - O-succinylhomoserine (thiol)-lyase Shew185_0536 206 COG0626 MetC, Cystathionine beta-lyases/cystathionine gamma-synthases Amino acid transport and metabolism 153001317 Common - siroheme synthase Shew185_2801 154 COG1648 CysG, Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) Coenzyme metabolism 152999526 Common - protein of unknown function DUF805 Shew185_0992 26 COG3152 COG3152, Predicted membrane protein Function unknown 152999256 Common - alanine racemase Shew185_0717 199 COG0787 Alr, Alanine racemase Cell envelope biogenesis, outer membrane 153001107 Common - dihydrodipicolinate synthase Shew185_2590 235 COG0329 DapA, Dihydrodipicolinate synthase/N-acetylneuraminate lyase Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane 152999860 Common - cobalamin synthesis protein P47K Shew185_1328 127 COG0523 COG0523, Putative GTPases (G3E family) General function prediction only 152999204 Common - Alkaline phosphatase Shew185_0664 85 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 153000794 Common - short-chain dehydrogenase/reductase SDR Shew185_2274 237 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153000449 Common - Peptidoglycan-binding domain 1 protein Shew185_1924 74 COG2989 COG2989, Uncharacterized protein conserved in bacteria Function unknown 153001654 Common - Methionine synthase vitamin-B12 independent Shew185_3141 144 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 152999867 Common - AAA ATPase central domain protein Shew185_1335 17 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 152998769 Common - preprotein translocase, SecY subunit Shew185_0216 237 COG0201 SecY, Preprotein translocase subunit SecY Intracellular trafficking and secretion 153001348 Common - major facilitator superfamily MFS_1 Shew185_2832 63 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152999254 Common - hypothetical protein Shew185_0715 21 None None None 153000028 Common - hypothetical protein Shew185_1496 1 None None None 152998849 Common - transposase IS4 family protein Shew185_0296 33 COG5433 COG5433, Transposase DNA replication, recombination, and repair 153000407 Common - GTP-binding protein HSR1-related Shew185_1882 105 COG1161 COG1161, Predicted GTPases General function prediction only 153002397 Common - 4-hydroxybenzoate polyprenyl transferase Shew185_3891 169 COG0382 UbiA, 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases Coenzyme metabolism 153001872 Common - phage integrase family protein Shew185_3363 31 COG0582 XerC, Integrase DNA replication, recombination, and repair 153002845 Common - protein of unknown function DUF414 Shew185_4349 23 COG3078 COG3078, Uncharacterized protein conserved in bacteria Function unknown 152999094 Common - cytochrome c class I Shew185_0544 35 COG3258 COG3258, Cytochrome c Energy production and conversion 153001487 Common - Methyltransferase type 11 Shew185_2974 41 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153001043 Common - peptidase M23B Shew185_2524 184 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 152999329 Common - porin Gram-negative type Shew185_0790 23 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 153002587 Common - Fimbrial assembly family protein Shew185_4088 44 COG3166 PilN, Tfp pilus assembly protein PilN Cell motility and secretion / Intracellular trafficking and secretion 153001603 Common - HPP family protein? Shew185_3090 75 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 153002444 Common - O-antigen polymerase Shew185_3941 13 None None None 153001716 Nonpathogen - hypothetical protein Shew185_3206 1 None None None 152999027 Common - ribosomal protein L31 Shew185_0477 190 COG0254 RpmE, Ribosomal protein L31 Translation, ribosomal structure and biogenesis 153001539 Common - Threonine aldolase Shew185_3026 94 COG2008 GLY1, Threonine aldolase Amino acid transport and metabolism 153001611 Common - DEAD/DEAH box helicase domain protein Shew185_3098 240 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 153002449 Common - protein of unknown function DUF1342 Shew185_3946 44 COG4582 COG4582, Uncharacterized protein conserved in bacteria Function unknown 153002011 Common - hypothetical protein Shew185_3502 1 None None None 153002574 Common - transcriptional regulator, LysR family Shew185_4074 185 COG0583 LysR, Transcriptional regulator Transcription 153001763 Common - phage integrase family protein Shew185_3254 29 COG0582 XerC, Integrase DNA replication, recombination, and repair 153002302 Common - 1-acyl-sn-glycerol-3-phosphate acyltransferase Shew185_3796 149 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 152998796 Common - cytochrome B561 Shew185_0243 49 COG3658 COG3658, Cytochrome b Energy production and conversion 153000560 Common - Cyclomaltodextrinase Shew185_2036 156 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 152999126 Common - YD repeat protein Shew185_0579 39 COG3209 RhsA, Rhs family protein Cell envelope biogenesis, outer membrane 152999934 Common - polysaccharide deacetylase Shew185_1402 28 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 152999493 Common - Rhomboid family protein Shew185_0958 143 COG0705 GlpG, Uncharacterized membrane protein (homolog of Drosophila rhomboid) General function prediction only 153001672 Common - ATP-cone domain protein Shew185_3160 176 COG1327 COG1327, Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains Transcription 153000841 Common - UBA/THIF-type NAD/FAD binding protein Shew185_2321 213 COG0476 ThiF, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 Coenzyme metabolism 153001085 Nonpathogen - hypothetical protein Shew185_2568 1 None None None 153000094 Common - hypothetical protein Shew185_1565 1 None None None 153002309 Common - MscS Mechanosensitive ion channel Shew185_3803 204 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 152999181 Common - FxsA cytoplasmic membrane protein Shew185_0638 76 COG3030 FxsA, Protein affecting phage T7 exclusion by the F plasmid General function prediction only 152999221 Common - Phosphotransferase system, phosphocarrier protein HPr Shew185_0682 145 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 153001341 Common - Tripartite ATP-independent periplasmic transporter DctQ component Shew185_2825 43 COG3090 DctM, TRAP-type C4-dicarboxylate transport system, small permease component Carbohydrate transport and metabolism 152999980 Common - ribosome recycling factor Shew185_1448 216 COG0233 Frr, Ribosome recycling factor Translation, ribosomal structure and biogenesis 152999296 Common - gifsy-2 prophage; putative RecA/RadA recombinase Shew185_0757 9 COG5471 COG5471, Uncharacterized conserved protein Function unknown 152999527 Common - protein of unknown function DUF1486 Shew185_0993 11 COG4538 COG4538, Uncharacterized conserved protein Function unknown 153001302 Common - Tetratricopeptide TPR_2 repeat protein Shew185_2786 63 COG5271 MDN1, AAA ATPase containing von Willebrand factor type A (vWA) domain General function prediction only 153000929 Common - FAD dependent oxidoreductase Shew185_2410 94 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 152999192 Nonpathogen - hypothetical protein Shew185_0651 3 None None None 152999235 Common - SpoIIAA family protein Shew185_0696 5 COG3113 COG3113, Predicted NTP binding protein (contains STAS domain) General function prediction only 153002700 Common - RNA binding S1 domain protein Shew185_4202 151 COG2183 Tex, Transcriptional accessory protein Transcription 153001913 Common - peptidase M48 Ste24p Shew185_3404 129 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 153000323 Common - hypothetical protein Shew185_1798 13 None None None 152999322 Common - protein of unknown function DUF1249 Shew185_0783 23 COG3151 COG3151, Uncharacterized protein conserved in bacteria Function unknown 153002367 Common - hypothetical protein Shew185_3861 12 None None None 152999213 Common - hypothetical protein Shew185_0673 26 COG3907 COG3907, PAP2 (acid phosphatase) superfamily protein General function prediction only 152999941 Common - hypothetical protein Shew185_1409 15 COG3386 COG3386, Gluconolactonase Carbohydrate transport and metabolism 153000011 Common - phenylalanine-4-hydroxylase Shew185_1479 45 COG3186 COG3186, Phenylalanine-4-hydroxylase Amino acid transport and metabolism 153002250 Common - diguanylate cyclase/phosphodiesterase Shew185_3744 178 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 153002689 Common - MATE efflux family protein Shew185_4191 94 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 153002110 Common - 2-dehydropantoate 2-reductase Shew185_3603 105 COG1893 ApbA, Ketopantoate reductase Coenzyme metabolism 152998876 Common - hypothetical protein Shew185_0324 1 None None None 153001642 Common - peptidase M23B Shew185_3129 189 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 152998995 Common - protein of unknown function DUF971 Shew185_0445 50 COG3536 COG3536, Uncharacterized protein conserved in bacteria Function unknown 153000316 Common - thioesterase superfamily protein Shew185_1791 33 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 152998824 Common - PfkB domain protein Shew185_0271 4 COG0524 RbsK, Sugar kinases, ribokinase family Carbohydrate transport and metabolism 152999135 Common - hypothetical protein Shew185_0591 2 None None None 153002141 Common - Malate dehydrogenase (oxaloacetate-decarboxylating) Shew185_3634 199 COG0281 SfcA, Malic enzyme Energy production and conversion 153000889 Common - sulphate transporter Shew185_2369 159 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 152998649 Common - imidazolonepropionase Shew185_0095 116 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 153002509 Common - threonine dehydratase, biosynthetic Shew185_4006 226 COG1171 IlvA, Threonine dehydratase Amino acid transport and metabolism 152999502 Common - (2Fe-2S)-binding domain protein Shew185_0967 121 COG2080 CoxS, Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs Energy production and conversion 152999171 Common - acriflavin resistance protein Shew185_0628 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 153000758 Common - hypothetical protein Shew185_2238 9 None None None 153001910 Common - carbamoyl-phosphate synthase, small subunit Shew185_3401 234 COG0505 CarA, Carbamoylphosphate synthase small subunit Amino acid transport and metabolism / Nucleotide transport and metabolism 152999705 Common - succinic semialdehyde dehydrogenase Shew185_1171 221 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 153001682 Common - acriflavin resistance protein Shew185_3170 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 153002831 Common - glycosyl transferase group 1 Shew185_4335 117 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152998732 Common - UDP-N-acetylenolpyruvoylglucosamine reductase Shew185_0179 202 COG0812 MurB, UDP-N-acetylmuramate dehydrogenase Cell envelope biogenesis, outer membrane 153002404 Common - hypothetical protein Shew185_3898 1 None None None 153001180 Common - GCN5-related N-acetyltransferase Shew185_2663 2 None None None 152998755 Common - ribosomal protein S3 Shew185_0202 249 COG0092 RpsC, Ribosomal protein S3 Translation, ribosomal structure and biogenesis 152999146 Common - transposase IS4 family protein Shew185_0603 31 None None None 153001437 Common - GTP-binding signal recognition particle SRP54 G-domain protein Shew185_2921 247 COG1419 FlhF, Flagellar GTP-binding protein Cell motility and secretion 153000547 Common - Methylated-DNA-(protein)-cysteine S-methyltransferase DNA binding Shew185_2022 72 COG3695 COG3695, Predicted methylated DNA-protein cysteine methyltransferase DNA replication, recombination, and repair 153000922 Common - protein of unknown function DUF1568 Shew185_2403 21 None None None 152999066 Common - fumarate hydratase, class II Shew185_0516 238 COG0114 FumC, Fumarase Energy production and conversion 153000540 Common - DNA polymerase III, epsilon subunit Shew185_2015 187 COG0847 DnaQ, DNA polymerase III, epsilon subunit and related 3'-5' exonucleases DNA replication, recombination, and repair 153001851 Common - transport system permease protein Shew185_3342 40 COG4605 CeuC, ABC-type enterochelin transport system, permease component Inorganic ion transport and metabolism 153002671 Common - heavy metal efflux pump, CzcA family Shew185_4173 176 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 152999835 Common - hypothetical protein Shew185_1303 1 None None None 153002726 Common - transcriptional regulator, LysR family Shew185_4228 172 COG0583 LysR, Transcriptional regulator Transcription 153002582 Common - 3-dehydroquinate synthase Shew185_4083 206 COG0337 AroB, 3-dehydroquinate synthetase Amino acid transport and metabolism 153000107 Common - decaheme cytochrome c Shew185_1578 8 None None None 153001567 Common - Fe(II) trafficking protein YggX Shew185_3054 72 COG2924 COG2924, Uncharacterized protein conserved in bacteria Function unknown 153000557 Common - hypothetical protein Shew185_2033 8 None None None 152998757 Common - ribosomal protein L29 Shew185_0204 154 COG0255 RpmC, Ribosomal protein L29 Translation, ribosomal structure and biogenesis 152999939 Common - sigma54 specific transcriptional regulator, Fis family Shew185_1407 172 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153001626 Common - GCN5-related N-acetyltransferase Shew185_3113 21 None None None 153002756 Common - hypothetical protein Shew185_4258 1 None None None 153002800 Common - metal dependent phosphohydrolase Shew185_4304 123 COG2206 COG2206, HD-GYP domain Signal transduction mechanisms 152998909 Common - major facilitator superfamily MFS_1 Shew185_0357 25 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 152999987 Common - UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase Shew185_1455 157 COG1044 LpxD, UDP-3-O- 3-hydroxymyristoyl 153000139 Common - conserved hypothetical protein 1620 Shew185_1610 42 COG3768 COG3768, Predicted membrane protein Function unknown 153000550 Common - Lysine exporter protein (LYSE/YGGA) Shew185_2025 118 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 152999533 Common - protein of unknown function DUF214 Shew185_0999 55 COG0577 SalY, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 153000526 Common - TonB-dependent receptor Shew185_2001 67 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 153001325 Common - hypothetical protein Shew185_2809 1 None None None 153001074 Common - replication P family protein Shew185_2557 8 None None None 152998577 Common - Protoporphyrinogen oxidase Shew185_0022 33 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 152999975 Common - metal dependent phosphohydrolase Shew185_1443 123 COG2844 GlnD, UTP:GlnB (protein PII) uridylyltransferase Posttranslational modification, protein turnover, chaperones 153001861 Common - NUDIX hydrolase Shew185_3352 27 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 153000459 Common - periplasmic nitrate reductase NapE Shew185_1934 1 COG4459 NapE, Periplasmic nitrate reductase system, NapE component Energy production and conversion 153000949 Common - GCN5-related N-acetyltransferase Shew185_2430 32 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 152999474 Common - protein of unknown function DUF1111 Shew185_0938 50 COG3488 COG3488, Predicted thiol oxidoreductase Energy production and conversion 153001039 Common - Ion transport protein Shew185_2520 93 COG1226 Kch, Kef-type K+ transport systems, predicted NAD-binding component Inorganic ion transport and metabolism 153001426 Common - hypothetical protein Shew185_2910 13 None None None 152999415 Nonpathogen - hypothetical protein Shew185_0879 1 None None None 153002041 Common - hypothetical protein Shew185_3532 8 None None None 152999020 Common - band 7 protein Shew185_0470 210 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 152999099 Common - protein of unknown function DUF6 transmembrane Shew185_0549 98 COG2962 RarD, Predicted permeases General function prediction only 153002712 Common - hypothetical protein Shew185_4214 32 None None None 152999054 Common - peptidase U62 modulator of DNA gyrase Shew185_0504 170 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 153000615 Common - phage virion morphogenesis protein Shew185_2091 15 COG5005 COG5005, Mu-like prophage protein gpG General function prediction only 153000507 Common - transcriptional regulator, XRE family Shew185_1982 12 COG1476 COG1476, Predicted transcriptional regulators Transcription 153001965 Common - hypothetical protein Shew185_3456 5 None None None 153002833 Common - lipopolysaccharide kinase Shew185_4337 20 COG0478 COG0478, RIO-like serine/threonine protein kinase fused to N-terminal HTH domain Signal transduction mechanisms 152999152 Common - IS element transposase Shew185_0609 8 None None None 153002524 Common - 2-methylcitrate synthase/citrate synthase II Shew185_4022 194 COG0372 GltA, Citrate synthase Energy production and conversion 153000734 Common - AAA ATPase central domain protein Shew185_2213 228 COG2256 MGS1, ATPase related to the helicase subunit of the Holliday junction resolvase DNA replication, recombination, and repair 153000648 Common - Smr protein/MutS2 Shew185_2124 92 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 153000880 Common - Carbonate dehydratase Shew185_2360 149 COG0288 CynT, Carbonic anhydrase Inorganic ion transport and metabolism 153001575 Common - hypothetical protein Shew185_3062 13 None None None 153002323 Common - histone family protein DNA-binding protein Shew185_3817 209 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 153001892 Nonpathogen - hypothetical protein Shew185_3383 1 None None None 153001218 Common - protein of unknown function UPF0118 Shew185_2702 180 COG0628 PerM, Predicted permease General function prediction only 152999400 Common - hypothetical protein Shew185_0864 23 COG3529 COG3529, Predicted nucleic-acid-binding protein containing a Zn-ribbon domain General function prediction only 153000429 Common - hydrogenase nickel insertion protein HypA Shew185_1904 83 COG0375 HybF, Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) General function prediction only 152998994 Common - hypothetical protein Shew185_0444 1 None None None 153000867 Common - methyl-accepting chemotaxis sensory transducer Shew185_2347 155 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152999844 Common - iron-containing alcohol dehydrogenase Shew185_1312 174 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 153001292 Nonpathogen - hypothetical protein Shew185_2776 1 None None None 152998772 Common - ribosomal protein S11 Shew185_0219 247 COG0100 RpsK, Ribosomal protein S11 Translation, ribosomal structure and biogenesis 152999693 Common - rare lipoprotein A Shew185_1159 136 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 152999113 Common - hypothetical protein Shew185_0563 2 None None None 153002775 Common - UvrD/REP helicase Shew185_4279 222 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 153002743 Common - hypothetical protein Shew185_4245 9 None None None 153000197 Common - protein of unknown function DUF343 Shew185_1670 100 COG2835 COG2835, Uncharacterized conserved protein Function unknown 153000886 Common - Rhodanese domain protein Shew185_2366 111 COG1054 COG1054, Predicted sulfurtransferase General function prediction only 153001776 Common - hypothetical protein Shew185_3267 1 None None None 152998977 Common - SNARE associated Golgi protein Shew185_0427 125 COG0586 DedA, Uncharacterized membrane-associated protein Function unknown 153000068 Nonpathogen - hypothetical protein Shew185_1539 1 None None None 152998901 Common - AMP-dependent synthetase and ligase Shew185_0349 209 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 152999749 Common - hypothetical protein Shew185_1216 1 None None None 153002707 Common - Redoxin domain protein Shew185_4209 81 COG0678 AHP1, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 153001011 Common - sodium:dicarboxylate symporter Shew185_2492 164 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 153000893 Common - drug resistance transporter, Bcr/CflA subfamily Shew185_2373 191 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153000132 Common - binding-protein-dependent transport systems inner membrane component Shew185_1603 219 COG0601 DppB, ABC-type dipeptide/oligopeptide/nickel transport systems, permease components Amino acid transport and metabolism / Inorganic ion transport and metabolism 153000363 Common - ATP dependent DNA ligase Shew185_1838 30 COG1793 CDC9, ATP-dependent DNA ligase DNA replication, recombination, and repair 153002591 Common - Argininosuccinate synthase Shew185_4092 216 COG0137 ArgG, Argininosuccinate synthase Amino acid transport and metabolism 153000269 Common - Tol-Pal system YbgF Shew185_1744 73 COG1729 COG1729, Uncharacterized protein conserved in bacteria Function unknown 153001958 Common - cytochrome bd ubiquinol oxidase subunit I Shew185_3449 162 COG1271 CydA, Cytochrome bd-type quinol oxidase, subunit 1 Energy production and conversion 153002821 Common - glycosyl transferase family 39 Shew185_4325 88 COG1807 ArnT, 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family Cell envelope biogenesis, outer membrane 152998727 Common - Stearoyl-CoA 9-desaturase Shew185_0174 65 COG1398 OLE1, Fatty-acid desaturase Lipid metabolism 152999998 Common - Non-specific serine/threonine protein kinase Shew185_1466 144 COG0553 HepA, Superfamily II DNA/RNA helicases, SNF2 family Transcription / DNA replication, recombination, and repair 152998741 Common - ribosomal protein L7/L12 Shew185_0188 211 COG0222 RplL, Ribosomal protein L7/L12 Translation, ribosomal structure and biogenesis 153000262 Common - Prolyl oligopeptidase Shew185_1737 118 COG1505 COG1505, Serine proteases of the peptidase family S9A Amino acid transport and metabolism 152999279 Common - putative phage repressor Shew185_0740 34 COG2932 COG2932, Predicted transcriptional regulator Transcription 153002651 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Shew185_4152 164 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 152999270 Nonpathogen - hypothetical protein Shew185_0731 1 None None None 153002786 Common - hypothetical protein Shew185_4290 15 None None None 152998789 Common - hypothetical protein Shew185_0236 1 None None None 152999685 Common - methylmalonate-semialdehyde dehydrogenase Shew185_1151 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 152999057 Common - ABC-2 type transporter Shew185_0507 69 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 152999570 Common - ribosomal protein L21 Shew185_1036 215 COG0261 RplU, Ribosomal protein L21 Translation, ribosomal structure and biogenesis 153001746 Common - CRISPR-associated protein, Csy3 family Shew185_3237 21 None None None 153002796 Common - hypothetical protein Shew185_4300 8 None None None 153001773 Common - hypothetical protein Shew185_3264 1 None None None 153001585 Common - Heavy metal transport/detoxification protein Shew185_3072 61 COG2608 CopZ, Copper chaperone Inorganic ion transport and metabolism 152999035 Common - MSHA biogenesis protein MshM Shew185_0485 70 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 153002849 Common - protein of unknown function DUF885 Shew185_4353 44 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 152998885 Common - thioesterase superfamily protein Shew185_0333 71 COG0824 FcbC, Predicted thioesterase General function prediction only 152998678 Common - Chorismate lyase Shew185_0125 48 COG3161 UbiC, 4-hydroxybenzoate synthetase (chorismate lyase) Coenzyme metabolism 152999651 Common - regulatory protein ArsR Shew185_1117 164 COG0640 ArsR, Predicted transcriptional regulators Transcription 153000369 Nonpathogen - hypothetical protein Shew185_1844 1 None None None 153002363 Common - major facilitator superfamily MFS_1 Shew185_3857 134 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152999116 Common - transposase IS4 family protein Shew185_0569 33 COG5433 COG5433, Transposase DNA replication, recombination, and repair 153000208 Common - integron integrase Shew185_1682 223 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 153002789 Common - SH3, type 3 domain protein Shew185_4293 2 None None None 153001295 Common - Integrase catalytic region Shew185_2779 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 153002257 Common - hypothetical protein Shew185_3751 23 None None None 152999846 Common - betaine aldehyde dehydrogenase Shew185_1314 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 153002559 Common - Radical SAM domain protein Shew185_4059 76 COG1032 COG1032, Fe-S oxidoreductase Energy production and conversion 152998751 Common - Ribosomal protein L25/L23 Shew185_0198 144 COG0089 RplW, Ribosomal protein L23 Translation, ribosomal structure and biogenesis 153000687 Common - hypothetical protein Shew185_2163 66 COG2836 COG2836, Uncharacterized conserved protein Function unknown 153000892 Common - alkaline phosphatase Shew185_2372 36 None None None 153000187 Common - hypothetical protein Shew185_1660 10 None None None 153002783 Common - putative secreted protein Shew185_4287 8 COG5266 CbiK, ABC-type Co2+ transport system, periplasmic component Inorganic ion transport and metabolism 152998770 Common - ribosomal protein L36 Shew185_0217 137 COG0257 RpmJ, Ribosomal protein L36 Translation, ribosomal structure and biogenesis 152999972 Common - formyltetrahydrofolate deformylase Shew185_1440 220 COG0788 PurU, Formyltetrahydrofolate hydrolase Nucleotide transport and metabolism 153002599 Common - formate dehydrogenase subunit FdhD Shew185_4100 136 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 153001298 Common - ATPase associated with various cellular activities AAA_3 Shew185_2782 179 COG0714 COG0714, MoxR-like ATPases General function prediction only 152999833 Common - SmpA/OmlA domain protein Shew185_1301 59 COG2913 SmpA, Small protein A (tmRNA-binding) Translation, ribosomal structure and biogenesis 152998858 Nonpathogen - hypothetical protein Shew185_0306 2 None None None 153002704 Common - two component transcriptional regulator, winged helix family Shew185_4206 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153000732 Common - seryl-tRNA synthetase Shew185_2211 244 COG0172 SerS, Seryl-tRNA synthetase Translation, ribosomal structure and biogenesis 153000498 Common - phage integrase family protein Shew185_1973 34 COG0582 XerC, Integrase DNA replication, recombination, and repair 152999826 Common - peptidase S16, lon domain protein Shew185_1294 118 COG1067 LonB, Predicted ATP-dependent protease Posttranslational modification, protein turnover, chaperones 153000830 Common - putative methyltransferase Shew185_2310 56 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 153000420 Common - septum site-determining protein MinC Shew185_1895 109 COG0850 MinC, Septum formation inhibitor Cell division and chromosome partitioning 152998733 Common - biotin--acetyl-CoA-carboxylase ligase Shew185_0180 228 COG0340 BirA, Biotin-(acetyl-CoA carboxylase) ligase Coenzyme metabolism 152998844 Common - TonB-dependent receptor Shew185_0291 98 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 153001305 Common - hypothetical protein Shew185_2789 8 None None None 153001574 Common - hypothetical protein Shew185_3061 25 None None None 153000579 Common - oxidoreductase molybdopterin binding Shew185_2055 125 COG2041 COG2041, Sulfite oxidase and related enzymes General function prediction only 152999236 Common - BolA family protein Shew185_0697 80 COG5007 COG5007, Predicted transcriptional regulator, BolA superfamily Transcription 153000973 Common - aminotransferase class IV Shew185_2454 157 COG0115 IlvE, Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase Amino acid transport and metabolism / Coenzyme metabolism 152998613 Common - NLP/P60 protein Shew185_0058 145 COG0791 Spr, Cell wall-associated hydrolases (invasion-associated proteins) Cell envelope biogenesis, outer membrane 153002842 Common - GTP-binding protein HSR1-related Shew185_4346 178 COG0218 COG0218, Predicted GTPase General function prediction only 152998787 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Shew185_0234 151 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 153001604 Common - short chain fatty acid transporter Shew185_3091 40 COG2031 AtoE, Short chain fatty acids transporter Lipid metabolism 153000199 Common - hypothetical protein Shew185_1672 16 COG3235 COG3235, Predicted membrane protein Function unknown 153002515 Common - protein of unknown function DUF21 Shew185_4012 217 COG1253 TlyC, Hemolysins and related proteins containing CBS domains General function prediction only 153001221 Common - sodium/glutamate symporter Shew185_2705 53 COG0786 GltS, Na+/glutamate symporter Amino acid transport and metabolism 153000501 Common - EcoEI R domain protein Shew185_1976 138 COG4096 HsdR, Type I site-specific restriction-modification system, R (restriction) subunit and related helicases Defense mechanisms 153001323 Common - queuine tRNA-ribosyltransferase Shew185_2807 231 COG0343 Tgt, Queuine/archaeosine tRNA-ribosyltransferase Translation, ribosomal structure and biogenesis 153000134 Common - transcriptional regulator, Fis family Shew185_1605 170 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 153000248 Common - acyl-CoA dehydrogenase domain protein Shew185_1723 145 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 152998642 Common - hypothetical protein Shew185_0087 1 None None None 153001960 Nonpathogen - hypothetical protein Shew185_3451 1 None None None 152999691 Common - fumarate reductase/succinate dehydrogenase flavoprotein domain protein Shew185_1157 55 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 153001053 Common - flavocytochrome c Shew185_2534 204 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 153002610 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Shew185_4111 176 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 152999758 Common - transcriptional regulator, LysR family Shew185_1225 186 COG0583 LysR, Transcriptional regulator Transcription 153002741 Common - protein of unknown function DUF519 Shew185_4243 85 COG2961 ComJ, Protein involved in catabolism of external DNA General function prediction only 153002594 Common - N-acetyl-gamma-glutamyl-phosphate reductase Shew185_4095 214 COG0002 ArgC, Acetylglutamate semialdehyde dehydrogenase Amino acid transport and metabolism 153001880 Common - putative phage repressor Shew185_3371 54 COG2932 COG2932, Predicted transcriptional regulator Transcription 153000409 Common - peptide methionine sulfoxide reductase Shew185_1884 206 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 153001481 Common - protein of unknown function DUF400 Shew185_2968 16 COG3018 COG3018, Uncharacterized protein conserved in bacteria Function unknown 153000268 Common - Peptidoglycan-associated lipoprotein Shew185_1743 151 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 153002317 Common - hypothetical protein Shew185_3811 14 None None None 153002682 Nonpathogen - hypothetical protein Shew185_4184 1 None None None 153000523 Common - protein of unknown function DUF6 transmembrane Shew185_1998 69 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 153000725 Common - transcriptional regulator, LysR family Shew185_2204 174 COG0583 LysR, Transcriptional regulator Transcription 153000120 Common - Methenyltetrahydrofolate cyclohydrolase Shew185_1591 223 COG0190 FolD, 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase Coenzyme metabolism 153000056 Common - protein of unknown function DUF1415 Shew185_1526 30 COG3310 COG3310, Uncharacterized protein conserved in bacteria Function unknown 152999021 Common - band 7 protein Shew185_0471 216 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 152998829 Common - Electron-transferring-flavoprotein dehydrogenase Shew185_0276 108 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 153000610 Common - hypothetical protein Shew185_2086 12 None None None 153000217 Nonpathogen - hypothetical protein Shew185_1691 1 None None None 153002813 Common - extracellular solute-binding protein, family 1 Shew185_4317 62 COG2998 TupB, ABC-type tungstate transport system, permease component Coenzyme metabolism 152999979 Common - uridylate kinase Shew185_1447 236 COG0528 PyrH, Uridylate kinase Nucleotide transport and metabolism 152999172 Common - Sel1 domain protein repeat-containing protein Shew185_0629 3 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 152999942 Common - hypothetical protein Shew185_1410 1 None None None 152998680 Common - protein of unknown function DUF890 Shew185_0127 28 COG3129 COG3129, Predicted SAM-dependent methyltransferase General function prediction only 153001087 Nonpathogen - hypothetical protein Shew185_2570 1 None None None 153001248 Common - IucA/IucC family protein Shew185_2732 49 COG4264 RhbC, Siderophore synthetase component Secondary metabolites biosynthesis, transport, and catabolism 153002774 Common - transposase IS3/IS911 family protein Shew185_4278 147 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 153000768 Common - response regulator receiver protein Shew185_2248 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153002308 Common - hypothetical protein Shew185_3802 1 None None None 153001865 Nonpathogen - hypothetical protein Shew185_3356 1 None None None 152999430 Common - diguanylate cyclase Shew185_0894 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152999260 Common - 2OG-Fe(II) oxygenase Shew185_0721 46 COG3128 PiuC, Uncharacterized iron-regulated protein Function unknown 152998997 Common - 20S proteasome A and B subunits Shew185_0447 149 COG5405 HslV, ATP-dependent protease HslVU (ClpYQ), peptidase subunit Posttranslational modification, protein turnover, chaperones 153000320 Common - hypothetical protein Shew185_1795 9 None None None 153002588 Common - type IV pilus assembly protein PilM Shew185_4089 80 COG4972 PilM, Tfp pilus assembly protein, ATPase PilM Cell motility and secretion / Intracellular trafficking and secretion 153000535 Common - MLTD_N domain protein Shew185_2010 127 COG1388 LytE, FOG: LysM repeat Cell envelope biogenesis, outer membrane 153001590 Common - methyl-accepting chemotaxis sensory transducer Shew185_3077 146 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152998783 Common - Tetratricopeptide domain protein Shew185_0230 54 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 153001412 Common - polysaccharide biosynthesis protein Shew185_2896 28 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 153002641 Common - hypothetical protein Shew185_4142 1 None None None 153002446 Common - type II secretion system protein Shew185_3943 143 COG1459 PulF, Type II secretory pathway, component PulF Cell motility and secretion / Intracellular trafficking and secretion 153000376 Common - hypothetical protein Shew185_1851 1 None None None 153002200 Common - extracellular solute-binding protein family 1 Shew185_3693 107 COG1840 AfuA, ABC-type Fe3+ transport system, periplasmic component Inorganic ion transport and metabolism 153001119 Common - Integrase catalytic region Shew185_2602 135 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 153001473 Common - flagellar hook capping protein Shew185_2960 104 COG1843 FlgD, Flagellar hook capping protein Cell motility and secretion 152998904 Common - DNA-directed RNA polymerase, omega subunit Shew185_0352 77 COG1758 RpoZ, DNA-directed RNA polymerase, subunit K/omega Transcription 153002826 Common - hypothetical protein Shew185_4330 16 None None None 153000948 Common - uncharacterised conserved protein UCP025560 Shew185_2429 30 COG3784 COG3784, Uncharacterized protein conserved in bacteria Function unknown 153001015 Common - 2OG-Fe(II) oxygenase Shew185_2496 11 None None None 152999293 Common - hypothetical protein Shew185_0754 3 None None None 153001041 Common - protein of unknown function DUF991 Shew185_2522 20 COG3102 COG3102, Uncharacterized protein conserved in bacteria Function unknown 153000193 Common - hypothetical protein Shew185_1666 47 COG3216 COG3216, Uncharacterized protein conserved in bacteria Function unknown 153002727 Common - Chloramphenicol O-acetyltransferase Shew185_4229 156 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 153002738 Common - TonB family protein Shew185_4240 53 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 153001893 Common - phage integrase family protein Shew185_3384 26 COG4973 XerC, Site-specific recombinase XerC DNA replication, recombination, and repair 152999558 Common - lipid A ABC exporter family, fused ATPase and inner membrane subunits Shew185_1024 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 153001105 Common - efflux transporter, RND family, MFP subunit Shew185_2588 173 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153001915 Common - DEAD/DEAH box helicase domain protein Shew185_3406 236 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 152999225 Common - RNA polymerase, sigma 54 subunit, RpoN Shew185_0686 145 COG1508 RpoN, DNA-directed RNA polymerase specialized sigma subunit, sigma54 homolog Transcription 153002412 Common - thioredoxin Shew185_3906 231 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 152999577 Common - methyl-accepting chemotaxis sensory transducer Shew185_1043 147 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152999353 Common - transcriptional regulator, LysR family Shew185_0814 180 COG0583 LysR, Transcriptional regulator Transcription 153000756 Common - hypothetical protein Shew185_2236 37 COG4628 COG4628, Uncharacterized conserved protein Function unknown 153002506 Common - hypothetical protein Shew185_4003 1 None None None 153000928 Common - transcriptional regulator, LysR family Shew185_2409 184 COG0583 LysR, Transcriptional regulator Transcription 153001565 Common - tRNA (guanine-N(7)-)-methyltransferase Shew185_3052 179 COG0220 COG0220, Predicted S-adenosylmethionine-dependent methyltransferase General function prediction only 152998851 Common - anaerobic c4-dicarboxylate antiporter, Dcu family Shew185_0298 36 COG2704 DcuB, Anaerobic C4-dicarboxylate transporter General function prediction only 153001699 Common - Adenylosuccinate synthase Shew185_3187 235 COG0104 PurA, Adenylosuccinate synthase Nucleotide transport and metabolism 153001854 Common - TonB-dependent receptor Shew185_3345 95 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 153002648 Common - amino acid permease-associated region Shew185_4149 178 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 153002528 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Shew185_4026 195 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 153001684 Common - transcriptional regulator, AraC family Shew185_3172 72 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 152999985 Common - surface antigen (D15) Shew185_1453 160 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 153001967 Common - FMN-binding domain protein Shew185_3458 13 COG4659 RnfG, Predicted NADH:ubiquinone oxidoreductase, subunit RnfG Energy production and conversion 153000791 Common - D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase Shew185_2271 102 COG2027 DacB, D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) Cell envelope biogenesis, outer membrane 153002484 Common - HemY domain protein Shew185_3981 45 COG3071 HemY, Uncharacterized enzyme of heme biosynthesis Coenzyme metabolism 152998976 Common - hypothetical protein Shew185_0425 7 None None None 152999206 Common - hypothetical protein Shew185_0666 7 None None None 152999702 Common - binding-protein-dependent transport systems inner membrane component Shew185_1168 196 COG1176 PotB, ABC-type spermidine/putrescine transport system, permease component I Amino acid transport and metabolism 153001666 Common - thiamine-monophosphate kinase Shew185_3153 202 COG0611 ThiL, Thiamine monophosphate kinase Coenzyme metabolism 153000355 Common - sortase family protein Shew185_1830 17 COG3764 SrtA, Sortase (surface protein transpeptidase) Cell envelope biogenesis, outer membrane 153000539 Common - Ribonuclease H Shew185_2014 177 COG0328 RnhA, Ribonuclease HI DNA replication, recombination, and repair 153002552 Common - hypothetical protein Shew185_4052 2 None None None 153001033 Common - efflux transporter, RND family, MFP subunit Shew185_2514 178 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 152999144 Common - transposase IS3/IS911 family protein Shew185_0601 2 COG2963 COG2963, Transposase and inactivated derivatives DNA replication, recombination, and repair 152998706 Common - general secretion pathway protein H Shew185_0153 21 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 152999294 Common - phage portal protein, lambda family Shew185_0755 33 COG5511 COG5511, Bacteriophage capsid protein General function prediction only 153001887 Common - hypothetical protein Shew185_3378 1 None None None 153002301 Common - protein of unknown function DUF1260 Shew185_3795 23 COG3076 COG3076, Uncharacterized protein conserved in bacteria Function unknown 153001174 Common - protein of unknown function DUF482 Shew185_2657 81 COG3146 COG3146, Uncharacterized protein conserved in bacteria Function unknown 152999163 Common - hypothetical protein Shew185_0620 5 None None None 153002502 Common - putative transcriptional regulator, AsnC family Shew185_3999 125 COG1522 Lrp, Transcriptional regulators Transcription 153000176 Common - hypothetical protein Shew185_1649 1 None None None 152999485 Common - polar amino acid ABC transporter, inner membrane subunit Shew185_0950 175 COG0765 HisM, ABC-type amino acid transport system, permease component Amino acid transport and metabolism 153002174 Common - hypothetical protein Shew185_3667 7 None None None 153001597 Common - xanthosine phosphorylase Shew185_3084 145 COG0005 Pnp, Purine nucleoside phosphorylase Nucleotide transport and metabolism 153001757 Common - HipA domain protein Shew185_3248 53 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 153001444 Common - flagellar motor switch protein FliN Shew185_2928 122 COG1886 FliN, Flagellar motor switch/type III secretory pathway protein Cell motility and secretion / Intracellular trafficking and secretion 153002744 Common - LemA family protein Shew185_4246 130 COG1704 LemA, Uncharacterized conserved protein Function unknown 152999845 Common - transcriptional regulator, TetR family Shew185_1313 57 COG1309 AcrR, Transcriptional regulator Transcription 152998955 Common - cell division protein FtsA Shew185_0404 188 COG0849 FtsA, Actin-like ATPase involved in cell division Cell division and chromosome partitioning 153001601 Common - protein of unknown function DUF1294 Shew185_3088 53 COG3326 COG3326, Predicted membrane protein Function unknown 153000382 Nonpathogen - hypothetical protein Shew185_1857 1 None None None 153001946 Common - NADH:ubiquinone oxidoreductase, subunit B Shew185_3437 76 COG1805 NqrB, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB Energy production and conversion 152998650 Common - transcriptional regulator, GntR family Shew185_0096 109 COG2188 PhnF, Transcriptional regulators Transcription 153002844 Common - hypothetical protein Shew185_4348 18 None None None 153002581 Common - Sporulation domain protein Shew185_4082 6 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 152999123 Common - hypothetical protein Shew185_0576 11 None None None 152999696 Common - FAD dependent oxidoreductase Shew185_1162 119 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 153000404 Common - hypothetical protein Shew185_1879 21 None None None 152998866 Common - putative ribonuclease BN Shew185_0314 154 COG1295 Rbn, Predicted membrane protein Function unknown 153000008 Common - ferredoxin-type protein NapF Shew185_1476 70 COG1149 COG1149, MinD superfamily P-loop ATPase containing an inserted ferredoxin domain Energy production and conversion 153000259 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Shew185_1734 226 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 153002274 Common - tRNA delta(2)-isopentenylpyrophosphate transferase Shew185_3768 214 COG0324 MiaA, tRNA delta(2)-isopentenylpyrophosphate transferase Translation, ribosomal structure and biogenesis 153001314 Common - GCN5-related N-acetyltransferase Shew185_2798 26 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 153002382 Common - Rhodanese domain protein Shew185_3876 7 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152999009 Common - hypothetical protein Shew185_0459 9 COG3883 COG3883, Uncharacterized protein conserved in bacteria Function unknown 153002031 Common - single-stranded-DNA-specific exonuclease RecJ Shew185_3522 196 COG0608 RecJ, Single-stranded DNA-specific exonuclease DNA replication, recombination, and repair 153000236 Common - protein of unknown function DUF177 Shew185_1711 55 COG1399 COG1399, Predicted metal-binding, possibly nucleic acid-binding protein General function prediction only 153002240 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Shew185_3734 165 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153001846 Common - galactose-1-phosphate uridylyltransferase Shew185_3337 79 COG1085 GalT, Galactose-1-phosphate uridylyltransferase Energy production and conversion 153000903 Common - co-chaperone Hsc20 Shew185_2383 56 COG1076 DjlA, DnaJ-domain-containing proteins 1 Posttranslational modification, protein turnover, chaperones 153001530 Common - hypothetical protein Shew185_3017 42 COG3530 COG3530, Uncharacterized protein conserved in bacteria Function unknown 152999019 Common - protein of unknown function DUF107 Shew185_0469 2 COG1585 COG1585, Membrane protein implicated in regulation of membrane protease activity Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 153000477 Nonpathogen - hypothetical protein Shew185_1952 2 None None None 152999767 Common - hypothetical protein Shew185_1234 2 None None None 153001873 Nonpathogen - hypothetical protein Shew185_3364 1 None None None 153001683 Common - drug resistance transporter, Bcr/CflA subfamily Shew185_3171 221 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152999332 Common - hypothetical protein Shew185_0793 2 None None None 153000899 Common - protein of unknown function DUF528 Shew185_2379 43 COG2975 COG2975, Uncharacterized protein conserved in bacteria Function unknown 153000587 Common - electron transport complex, RnfABCDGE type, C subunit Shew185_2063 84 COG4656 RnfC, Predicted NADH:ubiquinone oxidoreductase, subunit RnfC Energy production and conversion 152998715 Common - Phytanoyl-CoA dioxygenase Shew185_0162 8 COG5285 COG5285, Protein involved in biosynthesis of mitomycin antibiotics/polyketide fumonisin Secondary metabolites biosynthesis, transport, and catabolism 152999563 Common - thiol:disulfide interchange protein, putative Shew185_1029 46 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 152998664 Common - hypothetical protein Shew185_0111 19 COG4461 LprI, Uncharacterized protein conserved in bacteria, putative lipoprotein Function unknown 152999580 Common - dimethyladenosine transferase Shew185_1046 248 COG0030 KsgA, Dimethyladenosine transferase (rRNA methylation) Translation, ribosomal structure and biogenesis 153001228 Common - protein of unknown function DUF470 Shew185_2712 80 COG2898 COG2898, Uncharacterized conserved protein Function unknown 153002346 Common - Antibiotic biosynthesis monooxygenase Shew185_3840 13 COG1359 COG1359, Uncharacterized conserved protein Function unknown 153002207 Common - hypothetical protein Shew185_3700 1 None None None 153000279 Common - dethiobiotin synthase Shew185_1754 153 COG0132 BioD, Dethiobiotin synthetase Coenzyme metabolism 153002763 Common - hypothetical protein Shew185_4266 65 COG3209 RhsA, Rhs family protein Cell envelope biogenesis, outer membrane 152999630 Common - hypothetical protein Shew185_1096 77 COG1238 COG1238, Predicted membrane protein Function unknown 152998969 Common - protein of unknown function DUF1243 Shew185_0418 29 COG3165 COG3165, Uncharacterized protein conserved in bacteria Function unknown 152999639 Common - von Willebrand factor type A Shew185_1105 37 COG2304 COG2304, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 153000824 Common - Holliday junction DNA helicase RuvA Shew185_2304 212 COG0632 RuvA, Holliday junction resolvasome, DNA-binding subunit DNA replication, recombination, and repair 153001859 Common - putative transcriptional regulator, XRE family Shew185_3350 9 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 152999105 Common - major facilitator superfamily MFS_1 Shew185_0555 203 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153001149 Common - hypothetical protein Shew185_2632 6 None None None 153000117 Common - UDP-2,3-diacylglucosamine hydrolase Shew185_1588 76 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 153000548 Common - peptide deformylase Shew185_2023 215 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 153002466 Common - ribosomal protein L11 methyltransferase Shew185_3963 181 COG2264 PrmA, Ribosomal protein L11 methylase Translation, ribosomal structure and biogenesis 153001764 Nonpathogen - hypothetical protein Shew185_3255 1 None None None 152998584 Common - DNA protecting protein DprA Shew185_0029 211 COG0758 Smf, Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake DNA replication, recombination, and repair / Intracellular trafficking and secretion 152999624 Common - CDP-diacylglycerol--serine O-phosphatidyltransferase Shew185_1090 138 COG1183 PssA, Phosphatidylserine synthase Lipid metabolism 153002608 Common - Formate dehydrogenase region TAT target Shew185_4109 2 None None None 153001445 Common - flagellar motor switch protein FliM Shew185_2929 113 COG1868 FliM, Flagellar motor switch protein Cell motility and secretion 152999892 Common - TPR repeat-containing protein Shew185_1360 15 None None None 152999251 Common - single-strand binding protein/Primosomal replication protein n Shew185_0712 23 COG2965 PriB, Primosomal replication protein N DNA replication, recombination, and repair 153001931 Common - aminoacyl-histidine dipeptidase Shew185_3422 56 COG2195 PepD, Di- and tripeptidases Amino acid transport and metabolism 152999444 Common - hypothetical protein Shew185_0908 12 COG3608 COG3608, Predicted deacylase General function prediction only 152998986 Common - dTDP-4-dehydrorhamnose reductase Shew185_0436 188 COG1091 RfbD, dTDP-4-dehydrorhamnose reductase Cell envelope biogenesis, outer membrane 153000639 Common - exsB protein Shew185_2115 175 COG0603 COG0603, Predicted PP-loop superfamily ATPase General function prediction only 152998813 Common - hypothetical protein Shew185_0260 16 None None None 152999042 Common - methylation site containing protein Shew185_0492 1 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 153002453 Common - Ppx/GppA phosphatase Shew185_3950 178 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 153000671 Common - peptide methionine sulfoxide reductase Shew185_2147 204 COG0225 MsrA, Peptide methionine sulfoxide reductase Posttranslational modification, protein turnover, chaperones 153002106 Common - hypothetical protein Shew185_3599 5 None None None 153000375 Nonpathogen - hypothetical protein Shew185_1850 1 None None None 153000101 Common - Catalase domain protein Shew185_1572 69 COG0753 KatE, Catalase Inorganic ion transport and metabolism 152998838 Common - hypothetical protein Shew185_0285 1 None None None 153001816 Common - apolipoprotein N-acyltransferase Shew185_3307 163 COG0815 Lnt, Apolipoprotein N-acyltransferase Cell envelope biogenesis, outer membrane 153002061 Common - aromatic amino acid permease Shew185_3552 37 COG0814 SdaC, Amino acid permeases Amino acid transport and metabolism 152999411 Common - putative adenylyl cyclase CyaB Shew185_0875 22 COG1437 CyaB, Adenylate cyclase, class 2 (thermophilic) Nucleotide transport and metabolism 153002249 Common - ATP-dependent helicase HrpB Shew185_3743 148 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 153000466 Common - hypothetical protein Shew185_1941 1 None None None 152999406 Common - DEAD/DEAH box helicase domain protein Shew185_0870 236 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 153000632 Nonpathogen - hypothetical protein Shew185_2108 1 None None None 152999834 Common - Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase Shew185_1302 7 COG3956 COG3956, Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain General function prediction only 152998960 Common - preprotein translocase, SecA subunit Shew185_0409 215 COG0653 SecA, Preprotein translocase subunit SecA (ATPase, RNA helicase) Intracellular trafficking and secretion 153001176 Common - ATP-dependent endonuclease of the OLD family Shew185_2659 27 COG3593 COG3593, Predicted ATP-dependent endonuclease of the OLD family DNA replication, recombination, and repair 153001906 Common - methyl-accepting chemotaxis sensory transducer Shew185_3397 58 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153000096 Common - AAA ATPase Shew185_1567 16 COG3593 COG3593, Predicted ATP-dependent endonuclease of the OLD family DNA replication, recombination, and repair 153000223 Nonpathogen - hypothetical protein Shew185_1697 7 None None None 153001643 Common - protein-L-isoaspartate O-methyltransferase Shew185_3130 156 COG2518 Pcm, Protein-L-isoaspartate carboxylmethyltransferase Posttranslational modification, protein turnover, chaperones 153000666 Common - CopG domain protein DNA-binding domain protein Shew185_2142 21 None None None 153001351 Common - hypothetical protein Shew185_2835 4 COG3126 COG3126, Uncharacterized protein conserved in bacteria Function unknown 153002114 Common - hypothetical protein Shew185_3607 25 None None None 152998763 Common - ribosomal protein S8 Shew185_0210 221 COG0096 RpsH, Ribosomal protein S8 Translation, ribosomal structure and biogenesis 152999212 Common - diguanylate cyclase/phosphodiesterase with GAF sensor Shew185_0672 176 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152999780 Common - DNA repair protein RecO Shew185_1247 62 COG1381 RecO, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 153001086 Common - hypothetical protein Shew185_2569 1 None None None 153001513 Common - exodeoxyribonuclease VII, large subunit Shew185_3000 205 COG1570 XseA, Exonuclease VII, large subunit DNA replication, recombination, and repair 153002621 Common - Patatin Shew185_4122 50 COG4667 COG4667, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 153002222 Common - Succinylglutamate desuccinylase/aspartoacylase Shew185_3716 28 COG3608 COG3608, Predicted deacylase General function prediction only 153000855 Common - YCII-related Shew185_2335 41 COG2350 COG2350, Uncharacterized protein conserved in bacteria Function unknown 153001001 Common - protein of unknown function DUF299 Shew185_2482 113 COG1806 COG1806, Uncharacterized protein conserved in bacteria Function unknown 153000642 Common - hypothetical protein Shew185_2118 1 None None None 153001394 Common - lipoprotein, putative Shew185_2878 13 None None None 152999401 Common - short-chain dehydrogenase/reductase SDR Shew185_0865 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153000332 Common - hypothetical protein Shew185_1807 7 None None None 152999775 Common - positive regulator of sigma E, RseC/MucC Shew185_1242 28 COG3086 RseC, Positive regulator of sigma E activity Signal transduction mechanisms 153002714 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and Chase sensor(s) Shew185_4216 193 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 153000739 Common - thioredoxin reductase Shew185_2218 247 COG0492 TrxB, Thioredoxin reductase Posttranslational modification, protein turnover, chaperones 153000394 Common - hypothetical protein Shew185_1869 45 COG3593 COG3593, Predicted ATP-dependent endonuclease of the OLD family DNA replication, recombination, and repair 153000128 Common - Trans-2-enoyl-CoA reductase (NAD(+)) Shew185_1599 25 COG3007 COG3007, Uncharacterized paraquat-inducible protein B Function unknown 153001037 Common - hypothetical protein Shew185_2518 1 None None None 152998895 Common - hypothetical protein Shew185_0343 12 COG4982 COG4982, 3-oxoacyl- acyl-carrier protein 153000778 Common - proteinase inhibitor I11 ecotin Shew185_2258 23 COG4574 Eco, Serine protease inhibitor ecotin General function prediction only 153002417 Common - permease Shew185_3911 85 COG0701 COG0701, Predicted permeases General function prediction only 152999668 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Shew185_1134 177 COG1252 Ndh, NADH dehydrogenase, FAD-containing subunit Energy production and conversion 153001537 Common - hypothetical protein Shew185_3024 6 None None None 152999644 Common - Glucose-6-phosphate isomerase Shew185_1110 198 COG0166 Pgi, Glucose-6-phosphate isomerase Carbohydrate transport and metabolism 153002068 Common - NADH:ubiquinone oxidoreductase, subunit E Shew185_3560 76 COG2209 NqrE, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrE Energy production and conversion 152999721 Common - RNA polymerase, sigma 70 subunit, RpoD Shew185_1188 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 152999819 Common - hypothetical protein Shew185_1287 30 COG4704 COG4704, Uncharacterized protein conserved in bacteria Function unknown 153001379 Common - Peptidyl-dipeptidase Dcp Shew185_2863 124 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 153000805 Common - transcriptional regulator, LysR family Shew185_2285 111 COG0583 LysR, Transcriptional regulator Transcription 153000711 Nonpathogen - hypothetical protein Shew185_2189 1 None None None 152999089 Common - methyl-accepting chemotaxis sensory transducer Shew185_0539 154 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152999825 Common - NADH:flavin oxidoreductase/NADH oxidase Shew185_1293 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 153002312 Common - MaoC domain protein dehydratase Shew185_3806 25 COG2030 MaoC, Acyl dehydratase Lipid metabolism 152999004 Common - NADH:flavin oxidoreductase/NADH oxidase Shew185_0454 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 153001091 Nonpathogen - hypothetical protein Shew185_2574 1 None None None 153002868 Common - ATP synthase I chain Shew185_4372 34 COG3312 AtpI, F0F1-type ATP synthase, subunit I Energy production and conversion 152999812 Common - PepSY-associated TM helix domain protein Shew185_1280 31 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 152999045 Common - MSHA biogenesis protein MshP Shew185_0495 8 None None None 153000598 Common - hypothetical protein Shew185_2074 1 None None None 153002295 Common - PhoH family protein Shew185_3789 197 COG1875 COG1875, Predicted ATPase related to phosphate starvation-inducible protein PhoH Signal transduction mechanisms 153001140 Common - transcriptional regulator, TraR/DksA family Shew185_2623 7 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 153001849 Common - periplasmic binding protein Shew185_3340 68 COG4607 CeuA, ABC-type enterochelin transport system, periplasmic component Inorganic ion transport and metabolism 152999615 Common - TPR repeat-containing protein Shew185_1081 16 None None None 152999626 Common - oxaloacetate decarboxylase alpha subunit Shew185_1092 201 COG5016 COG5016, Pyruvate/oxaloacetate carboxyltransferase Energy production and conversion 153000133 Common - extracellular solute-binding protein family 5 Shew185_1604 211 COG0747 DdpA, ABC-type dipeptide transport system, periplasmic component Amino acid transport and metabolism 153002532 Common - Na+ antiporter NhaC Shew185_4032 72 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 152999468 Common - integral membrane sensor signal transduction histidine kinase Shew185_0932 208 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153002218 Common - integral membrane sensor signal transduction histidine kinase Shew185_3712 128 COG3850 NarQ, Signal transduction histidine kinase, nitrate/nitrite-specific Signal transduction mechanisms 152998928 Common - ribosomal protein L28 Shew185_0377 165 COG0227 RpmB, Ribosomal protein L28 Translation, ribosomal structure and biogenesis 152999870 Common - protein of unknown function DUF224 cysteine-rich region domain protein Shew185_1338 154 COG0247 GlpC, Fe-S oxidoreductase Energy production and conversion 153002070 Common - NADH:ubiquinone oxidoreductase, subunit C Shew185_3562 47 COG2869 NqrC, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrC Energy production and conversion 152999034 Common - pilus (MSHA type) biogenesis protein MshL Shew185_0484 144 COG1450 PulD, Type II secretory pathway, component PulD Cell motility and secretion / Intracellular trafficking and secretion 153002807 Common - isochorismate synthase Shew185_4311 222 COG1169 MenF, Isochorismate synthase Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152999890 Common - conserved hypothetical protein 730 Shew185_1358 45 COG1611 COG1611, Predicted Rossmann fold nucleotide-binding protein General function prediction only 153000274 Common - integral membrane sensor hybrid histidine kinase Shew185_1749 221 COG0591 PutP, Na+/proline symporter Amino acid transport and metabolism / General function prediction only 152999302 Common - transcriptional regulator, Cro/CI/xre family Shew185_0763 44 COG2944 COG2944, Predicted transcriptional regulator Transcription 153000963 Common - Paraquat-inducible protein A Shew185_2444 44 COG2995 PqiA, Uncharacterized paraquat-inducible protein A Function unknown 152998652 Common - histidine ammonia-lyase Shew185_0098 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 152999544 Common - UspA domain protein Shew185_1010 61 COG0589 UspA, Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms 153001364 Common - Enoyl-CoA hydratase/isomerase Shew185_2848 179 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 153001648 Common - Septum formation initiator Shew185_3135 65 COG2919 COG2919, Septum formation initiator Cell division and chromosome partitioning 153000343 Common - hypothetical protein Shew185_1818 2 None None None 153000417 Common - ribonuclease D Shew185_1892 120 COG0349 Rnd, Ribonuclease D Translation, ribosomal structure and biogenesis 153001422 Common - response regulator receiver protein Shew185_2906 223 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153001956 Common - O-acetylhomoserine/O-acetylserine sulfhydrylase Shew185_3447 206 COG2873 MET17, O-acetylhomoserine sulfhydrylase Amino acid transport and metabolism 153001503 Common - methyl-accepting chemotaxis sensory transducer Shew185_2990 150 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153001403 Common - protein of unknown function DUF886 Shew185_2887 36 COG3758 COG3758, Uncharacterized protein conserved in bacteria Function unknown 153000482 Common - hypothetical protein Shew185_1957 1 None None None 152999718 Common - glycoside hydrolase family 3 domain protein Shew185_1185 104 COG1472 BglX, Beta-glucosidase-related glycosidases Carbohydrate transport and metabolism 153001284 Common - major facilitator superfamily MFS_1 Shew185_2768 96 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 153001830 Common - Serine-type D-Ala-D-Ala carboxypeptidase Shew185_3321 155 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 153002391 Common - putative mitomycin resistance protein Shew185_3885 12 None None None 153000145 Common - primosomal replication protein N'', putative Shew185_1616 8 COG3923 PriC, Primosomal replication protein N'' DNA replication, recombination, and repair 153000060 Common - putative esterase Shew185_1530 29 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 153002665 Common - NapC/NirT cytochrome c domain protein Shew185_4167 47 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 153000647 Common - hypothetical protein Shew185_2123 1 None None None 152999920 Common - cyclic nucleotide-binding protein Shew185_1388 18 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 153002162 Common - CBS domain containing protein Shew185_3655 74 COG3448 COG3448, CBS-domain-containing membrane protein Signal transduction mechanisms 152999787 Common - ribosomal protein S16 Shew185_1254 212 COG0228 RpsP, Ribosomal protein S16 Translation, ribosomal structure and biogenesis 153001641 Common - RNA polymerase, sigma 70 subunit, RpoD family Shew185_3128 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 153001674 Common - ABC transporter related Shew185_3162 248 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 153002181 Common - hypothetical protein Shew185_3674 12 None None None 153000021 Common - acetyl-CoA acetyltransferase Shew185_1489 185 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 153002053 Common - hypothetical protein Shew185_3544 1 None None None 153001208 Common - pyruvate formate-lyase activating enzyme Shew185_2691 93 COG1180 PflA, Pyruvate-formate lyase-activating enzyme Posttranslational modification, protein turnover, chaperones 153002567 Common - hypothetical protein Shew185_4067 2 None None None 152999591 Common - hypothetical protein Shew185_1057 7 None None None 153000936 Nonpathogen - hypothetical protein Shew185_2417 3 None None None 152998573 Common - protein of unknown function UPF0029 Shew185_0018 133 COG1739 COG1739, Uncharacterized conserved protein Function unknown 153001625 Common - Carboxypeptidase Taq Shew185_3112 82 COG2317 COG2317, Zn-dependent carboxypeptidase Amino acid transport and metabolism 152998698 Common - Phosphoenolpyruvate carboxykinase (ATP) Shew185_0145 97 COG1866 PckA, Phosphoenolpyruvate carboxykinase (ATP) Energy production and conversion 153001256 Common - putative transcriptional regulator, Crp/Fnr family Shew185_2740 28 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 153002637 Common - drug resistance transporter, Bcr/CflA subfamily Shew185_4138 157 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153000667 Common - hypothetical protein Shew185_2143 8 None None None 153001806 Common - PepSY-associated TM helix domain protein Shew185_3297 29 COG3295 COG3295, Uncharacterized protein conserved in bacteria Function unknown 153002109 Common - VanZ family protein Shew185_3602 9 COG5652 COG5652, Predicted integral membrane protein Function unknown 152999346 Common - Alkaline phosphatase Shew185_0807 84 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 153002861 Common - ATP synthase F1, beta subunit Shew185_4365 247 COG0055 AtpD, F0F1-type ATP synthase, beta subunit Energy production and conversion 152999495 Common - MORN variant repeat protein Shew185_0960 30 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 152999242 Common - ribosomal protein S9 Shew185_0703 249 COG0103 RpsI, Ribosomal protein S9 Translation, ribosomal structure and biogenesis 152999371 Common - multi-sensor hybrid histidine kinase Shew185_0835 223 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153000015 Common - maleylacetoacetate isomerase Shew185_1483 60 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 153000155 Common - Biopolymer transport protein ExbD/TolR Shew185_1628 126 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 153002473 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Shew185_3970 70 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 153002188 Common - protein of unknown function DUF710 Shew185_3681 51 COG3027 COG3027, Uncharacterized protein conserved in bacteria Function unknown 153001058 Nonpathogen - hypothetical protein Shew185_2539 2 None None None 153000445 Common - two component transcriptional regulator, winged helix family Shew185_1920 218 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152999014 Common - hypothetical protein Shew185_0464 3 None None None 153002562 Common - hypothetical protein Shew185_4062 7 COG4775 COG4775, Outer membrane protein/protective antigen OMA87 Cell envelope biogenesis, outer membrane 153002579 Common - hypothetical protein Shew185_4080 9 None None None 153002153 Common - hypothetical protein Shew185_3646 18 COG5184 ATS1, Alpha-tubulin suppressor and related RCC1 domain-containing proteins Cell division and chromosome partitioning / Cytoskeleton 153001722 Common - trimethylamine-N-oxide reductase c-type cytochrome TorC Shew185_3212 49 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 153000993 Common - Cupin 4 family protein Shew185_2474 61 COG2850 COG2850, Uncharacterized conserved protein Function unknown 152998713 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Shew185_0160 45 COG1011 COG1011, Predicted hydrolase (HAD superfamily) General function prediction only 153002005 Common - 23S rRNA (uracil-5-)-methyltransferase RumB Shew185_3496 181 COG2265 TrmA, SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase Translation, ribosomal structure and biogenesis 153002048 Common - D-erythrose-4-phosphate dehydrogenase Shew185_3539 217 COG0057 GapA, Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase Carbohydrate transport and metabolism 153000567 Common - D-alanine--D-alanine ligase Shew185_2043 208 COG1181 DdlA, D-alanine-D-alanine ligase and related ATP-grasp enzymes Cell envelope biogenesis, outer membrane 153002630 Common - amidohydrolase Shew185_4131 167 COG1473 AbgB, Metal-dependent amidase/aminoacylase/carboxypeptidase General function prediction only 153002337 Common - redox-active disulfide protein 2 Shew185_3831 67 None None None 153002075 Common - hypothetical protein Shew185_3567 5 None None None 152999278 Common - SEC-C motif domain protein Shew185_0739 45 COG3318 COG3318, Predicted metal-binding protein related to the C-terminal domain of SecA General function prediction only 152999899 Common - Leukotriene A4 hydrolase Shew185_1367 139 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 152998647 Common - transcriptional regulator, MarR family Shew185_0093 32 COG1846 MarR, Transcriptional regulators Transcription 153001197 Common - cell division protein ZipA Shew185_2680 43 COG3115 ZipA, Cell division protein Cell division and chromosome partitioning 152999334 Common - methyl-accepting chemotaxis sensory transducer Shew185_0795 151 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153001268 Common - alpha/beta hydrolase fold Shew185_2752 32 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153000554 Common - FAD dependent oxidoreductase Shew185_2030 12 COG3349 COG3349, Uncharacterized conserved protein Function unknown 152998576 Common - regulatory protein ArsR Shew185_0021 160 COG0640 ArsR, Predicted transcriptional regulators Transcription 153002348 Common - drug resistance transporter, EmrB/QacA subfamily Shew185_3842 195 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153001738 Common - thymidine phosphorylase Shew185_3229 118 COG0213 DeoA, Thymidine phosphorylase Nucleotide transport and metabolism 153001755 Nonpathogen - hypothetical protein Shew185_3246 1 None None None 153000977 Common - methionyl-tRNA synthetase Shew185_2458 249 COG0143 MetG, Methionyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153002855 Common - hypothetical protein Shew185_4359 26 COG3205 COG3205, Predicted membrane protein Function unknown 153002320 Common - hypothetical protein Shew185_3814 7 None None None 152999387 Common - PepB aminopeptidase Shew185_0851 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 152999060 Common - Ig domain protein group 1 domain protein Shew185_0510 35 None None None 153001370 Common - ThiJ/PfpI domain protein Shew185_2854 49 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 153001190 Common - Na+ symporter Shew185_2673 167 COG4147 DhlC, Predicted symporter General function prediction only 152999472 Common - hypothetical protein Shew185_0936 19 COG1842 PspA, Phage shock protein A (IM30), suppresses sigma54-dependent transcription Transcription / Signal transduction mechanisms 152998990 Common - short-chain dehydrogenase/reductase SDR Shew185_0440 108 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152999457 Common - phosphoadenosine phosphosulfate reductase Shew185_0921 154 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 152999586 Common - heat shock protein DnaJ domain protein Shew185_1052 86 COG1076 DjlA, DnaJ-domain-containing proteins 1 Posttranslational modification, protein turnover, chaperones 152998934 Common - ATP-dependent DNA helicase RecQ Shew185_0383 235 COG0514 RecQ, Superfamily II DNA helicase DNA replication, recombination, and repair 153002095 Common - ABC-2 type transporter Shew185_3588 180 COG1682 TagG, ABC-type polysaccharide/polyol phosphate export systems, permease component Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane 152999995 Common - potassium efflux system protein Shew185_1463 217 COG0475 KefB, Kef-type K+ transport systems, membrane components Inorganic ion transport and metabolism 152998637 Common - putative transcriptional regulator, MerR family Shew185_0082 134 COG0789 SoxR, Predicted transcriptional regulators Transcription 153000657 Common - 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase Shew185_2133 126 COG0800 Eda, 2-keto-3-deoxy-6-phosphogluconate aldolase Carbohydrate transport and metabolism 153002655 Common - 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase Shew185_4157 133 COG1165 MenD, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Coenzyme metabolism 152999133 Nonpathogen - hypothetical protein Shew185_0589 1 None None None 153000381 Nonpathogen - hypothetical protein Shew185_1856 1 None None None 153001923 Common - hypothetical protein Shew185_3414 1 None None None 153001110 Common - Lysine exporter protein (LYSE/YGGA) Shew185_2593 84 COG1279 COG1279, Lysine efflux permease General function prediction only 153000109 Common - decaheme cytochrome c MtrF Shew185_1580 8 None None None 153000747 Common - MATE efflux family protein Shew185_2226 165 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 153000998 Common - protein of unknown function DUF1285 Shew185_2479 32 COG3816 COG3816, Uncharacterized protein conserved in bacteria Function unknown 152998801 Common - aldehyde dehydrogenase Shew185_0248 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 153002586 Common - Pilus assembly protein PilO Shew185_4087 48 COG3167 PilO, Tfp pilus assembly protein PilO Cell motility and secretion / Intracellular trafficking and secretion 153001380 Common - Na+ antiporter NhaC Shew185_2864 69 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 152998745 Common - ribosomal protein S7 Shew185_0192 243 COG0049 RpsG, Ribosomal protein S7 Translation, ribosomal structure and biogenesis 152998675 Common - hypothetical protein Shew185_0122 2 None None None 153002202 Common - Glutathione S-transferase domain Shew185_3695 64 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 153001908 Common - pseudouridine synthase Shew185_3399 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 152998561 Common - urea amidolyase related protein Shew185_0006 115 COG1984 DUR1, Allophanate hydrolase subunit 2 Amino acid transport and metabolism 153001165 Common - protein of unknown function DUF55 Shew185_2648 93 COG2947 COG2947, Uncharacterized conserved protein Function unknown 153000742 Common - translation initiation factor IF-3 Shew185_2221 212 COG0290 InfC, Translation initiation factor 3 (IF-3) Translation, ribosomal structure and biogenesis 153000882 Common - iron-containing alcohol dehydrogenase Shew185_2362 145 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 153000814 Common - signal peptide peptidase SppA, 67K type Shew185_2294 190 COG0616 SppA, Periplasmic serine proteases (ClpP class) Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 153000946 Common - hypothetical protein Shew185_2427 22 None None None 153001024 Common - succinyl-CoA synthetase, alpha subunit Shew185_2505 216 COG0074 SucD, Succinyl-CoA synthetase, alpha subunit Energy production and conversion 152999552 Common - Biopolymer transport protein ExbD/TolR Shew185_1018 3 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 152999393 Common - glucose-methanol-choline oxidoreductase Shew185_0857 50 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 152999936 Common - hypothetical protein Shew185_1404 7 None None None 153002018 Common - TonB-dependent receptor Shew185_3509 112 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 152999391 Common - alpha/beta hydrolase fold Shew185_0855 71 COG0429 COG0429, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 153000678 Common - hypothetical protein Shew185_2154 7 None None None 152999281 Common - hypothetical protein Shew185_0742 2 None None None 153000918 Nonpathogen - hypothetical protein Shew185_2398 1 None None None 153001580 Common - protein of unknown function DUF1486 Shew185_3067 28 None None None 152999504 Nonpathogen - hypothetical protein Shew185_0969 1 None None None 153002173 Common - methyl-accepting chemotaxis sensory transducer Shew185_3666 158 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153001230 Common - hypothetical protein Shew185_2714 13 None None None 153000514 Nonpathogen - hypothetical protein Shew185_1989 2 None None None 153001829 Common - rare lipoprotein A Shew185_3320 137 COG0797 RlpA, Lipoproteins Cell envelope biogenesis, outer membrane 152999092 Common - response regulator receiver protein Shew185_0542 11 COG1289 COG1289, Predicted membrane protein Function unknown 153002691 Common - flavocytochrome c Shew185_4193 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 152998943 Common - MraZ protein Shew185_0392 140 COG2001 COG2001, Uncharacterized protein conserved in bacteria Function unknown 152999262 Common - Protein of unknown function DUF1778 Shew185_0723 3 COG4453 COG4453, Uncharacterized protein conserved in bacteria Function unknown 153001558 Common - non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family Shew185_3045 237 COG0127 COG0127, Xanthosine triphosphate pyrophosphatase Nucleotide transport and metabolism 153002356 Common - hypothetical protein Shew185_3850 1 None None None 152999482 Common - RarD protein, DMT superfamily transporter Shew185_0947 90 COG2962 RarD, Predicted permeases General function prediction only 153000464 Common - Domain of unknown function DUF1801 Shew185_1939 6 None None None 152999362 Common - hypothetical protein Shew185_0826 20 COG4726 PilX, Tfp pilus assembly protein PilX Cell motility and secretion / Intracellular trafficking and secretion 153002121 Common - peptide chain release factor 1 Shew185_3614 216 COG0216 PrfA, Protein chain release factor A Translation, ribosomal structure and biogenesis 153000037 Common - Domain of unknown function DUF1888 Shew185_1507 1 None None None 153001788 Common - ribosome-binding factor A Shew185_3279 135 COG0858 RbfA, Ribosome-binding factor A Translation, ribosomal structure and biogenesis 153002125 Common - ribose-phosphate pyrophosphokinase Shew185_3618 244 COG0462 PrsA, Phosphoribosylpyrophosphate synthetase Nucleotide transport and metabolism / Amino acid transport and metabolism 153001938 Common - bacterioferritin Shew185_3429 109 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 153000493 Nonpathogen - hypothetical protein Shew185_1968 1 None None None 153000660 Common - aminotransferase class I and II Shew185_2136 240 COG0436 COG0436, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 152999575 Common - Dihydrofolate reductase Shew185_1041 147 COG0262 FolA, Dihydrofolate reductase Coenzyme metabolism 153000089 Common - branched-chain amino acid transport Shew185_1560 4 COG4392 COG4392, Predicted membrane protein Function unknown 152999511 Common - transport system permease protein Shew185_0976 192 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 152999189 Nonpathogen - PBS lyase HEAT domain protein repeat-containing protein Shew185_0647 3 COG1413 COG1413, FOG: HEAT repeat Energy production and conversion 152999769 Common - protein of unknown function DUF339 Shew185_1236 48 COG2938 COG2938, Uncharacterized conserved protein Function unknown 152998864 Common - hypothetical protein Shew185_0312 16 None None None 153002557 Common - gluconate transporter Shew185_4057 79 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 153000988 Common - pseudouridine synthase Shew185_2469 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 152999442 Common - peptidase M16 domain protein Shew185_0906 13 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 153002431 Common - HAD-superfamily hydrolase, subfamily IA, variant 3 Shew185_3926 178 COG0637 COG0637, Predicted phosphatase/phosphohexomutase General function prediction only 153001214 Common - transposase IS3/IS911 family protein Shew185_2697 142 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 152999201 Common - hypothetical protein Shew185_0661 7 None None None 153002482 Common - Uroporphyrinogen III synthase HEM4 Shew185_3979 64 COG1587 HemD, Uroporphyrinogen-III synthase Coenzyme metabolism 153000058 Common - hypothetical protein Shew185_1528 4 None None None 153002148 Common - transcriptional regulator, LysR family Shew185_3641 187 COG0583 LysR, Transcriptional regulator Transcription 152999606 Common - hypothetical protein Shew185_1072 2 None None None 153002639 Common - hypothetical protein Shew185_4140 1 None None None 153002261 Common - Alpha/beta hydrolase fold-3 domain protein Shew185_3755 100 COG0657 Aes, Esterase/lipase Lipid metabolism 152998697 Common - sodium:dicarboxylate symporter Shew185_0144 164 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 152999157 Common - succinate dehydrogenase and fumarate reductase iron-sulfur protein Shew185_0614 206 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 153000080 Common - amino acid/peptide transporter Shew185_1551 80 COG3104 PTR2, Dipeptide/tripeptide permease Amino acid transport and metabolism 153001783 Common - Tetratricopeptide TPR_2 repeat protein Shew185_3274 49 COG4785 NlpI, Lipoprotein NlpI, contains TPR repeats General function prediction only 152998701 Common - general secretion pathway protein C Shew185_0148 30 COG3031 PulC, Type II secretory pathway, component PulC Intracellular trafficking and secretion 152999656 Common - lipoprotein signal peptidase Shew185_1122 206 COG0597 LspA, Lipoprotein signal peptidase Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 153000321 Common - nicotinamide mononucleotide transporter PnuC Shew185_1796 57 COG3201 PnuC, Nicotinamide mononucleotide transporter Coenzyme metabolism 153002266 Common - Glutathione S-transferase domain Shew185_3760 106 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 153001817 Common - methylation site containing protein Shew185_3308 1 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 152999433 Common - methyl-accepting chemotaxis sensory transducer Shew185_0897 154 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153002492 Common - diguanylate cyclase/phosphodiesterase with GAF sensor Shew185_3989 180 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 152998628 Common - ABC transporter related Shew185_0073 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 152999929 Common - ROK family protein Shew185_1397 157 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 153002537 Common - hypothetical protein Shew185_4037 4 None None None 153002758 Common - phage integrase family protein Shew185_4260 8 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 153000318 Common - protein of unknown function DUF1425 Shew185_1793 8 COG5633 COG5633, Predicted periplasmic lipoprotein General function prediction only 152999559 Common - AMP-dependent synthetase and ligase Shew185_1025 223 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153001134 Common - protein of unknown function DUF454 Shew185_2617 68 COG2832 COG2832, Uncharacterized protein conserved in bacteria Function unknown 153001125 Common - ABC transporter related Shew185_2608 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 153001521 Common - radical SAM enzyme, Cfr family Shew185_3008 194 COG0820 COG0820, Predicted Fe-S-cluster redox enzyme General function prediction only 153002523 Common - methylisocitrate lyase Shew185_4021 136 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 152999150 Common - efflux transporter, RND family, MFP subunit Shew185_0607 175 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153000581 Common - lactoylglutathione lyase Shew185_2057 122 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 152998917 Common - helix-turn-helix domain protein Shew185_0365 19 None None None 153000397 Common - putative transcriptional regulator, XRE family Shew185_1872 9 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 153000956 Common - protein of unknown function DUF1302 Shew185_2437 18 None None None 153001697 Common - extracellular solute-binding protein, family 3 Shew185_3185 12 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 153002398 Common - DNA helicase II Shew185_3892 232 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 152998798 Common - hypothetical protein Shew185_0245 1 None None None 152998621 Common - alpha-2-macroglobulin domain protein Shew185_0066 79 COG2373 COG2373, Large extracellular alpha-helical protein General function prediction only 153000455 Common - peptidase T2 asparaginase 2 Shew185_1930 84 COG1446 COG1446, Asparaginase Amino acid transport and metabolism 152999807 Nonpathogen - hypothetical protein Shew185_1274 1 None None None 153002427 Common - hypothetical protein Shew185_3921 1 None None None 152998879 Common - Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabA/FabZ Shew185_0327 25 COG4706 COG4706, Predicted 3-hydroxylacyl-(acyl carrier protein) dehydratase Lipid metabolism 153000071 Common - choline/carnitine/betaine transporter Shew185_1542 96 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 153001794 Common - phosphoglucosamine mutase Shew185_3285 241 COG1109 {ManB}, Phosphomannomutase Carbohydrate transport and metabolism 152999461 Common - hypothetical protein Shew185_0925 1 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 152998822 Common - hypothetical protein Shew185_0269 2 None None None 153002617 Common - Coproporphyrinogen dehydrogenase Shew185_4118 203 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 152998557 Common - DNA polymerase III, beta subunit Shew185_0002 215 COG0592 DnaN, DNA polymerase sliding clamp subunit (PCNA homolog) DNA replication, recombination, and repair 152999854 Common - glycogen debranching enzyme GlgX Shew185_1322 162 COG1523 PulA, Type II secretory pathway, pullulanase PulA and related glycosidases Carbohydrate transport and metabolism 152999369 Common - ABC transporter related Shew185_0833 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 153002736 Nonpathogen - Biopolymer transport protein ExbD/TolR Shew185_4238 2 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 152998954 Common - Polypeptide-transport-associated domain protein FtsQ-type Shew185_0403 77 COG1589 FtsQ, Cell division septal protein Cell envelope biogenesis, outer membrane 152999320 Common - type I secretion outer membrane protein, TolC family Shew185_0781 127 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 153002369 Common - transcriptional regulator, LysR family Shew185_3863 164 COG0583 LysR, Transcriptional regulator Transcription 153002238 Common - response regulator receiver protein Shew185_3732 200 COG4566 TtrR, Response regulator Signal transduction mechanisms 153002283 Common - protein of unknown function DUF6 transmembrane Shew185_3777 87 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 152999378 Common - Curlin associated repeat protein Shew185_0842 9 None None None 152999923 Common - protein of unknown function DUF134 Shew185_1391 42 COG1342 COG1342, Predicted DNA-binding proteins General function prediction only 153001272 Common - Colicin V production protein Shew185_2756 103 COG1286 CvpA, Uncharacterized membrane protein, required for colicin V production General function prediction only 153001461 Common - flagellin domain protein Shew185_2945 124 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 153000254 Common - phosphoribosylglycinamide formyltransferase Shew185_1729 223 COG0299 PurN, Folate-dependent phosphoribosylglycinamide formyltransferase PurN Nucleotide transport and metabolism 152999950 Common - PfaB family protein Shew185_1418 16 COG3321 COG3321, Polyketide synthase modules and related proteins Secondary metabolites biosynthesis, transport, and catabolism 153002499 Common - Inner membrane CreD family protein Shew185_3996 29 COG4452 CreD, Inner membrane protein involved in colicin E2 resistance Defense mechanisms 152999798 Common - sigma 54 modulation protein/ribosomal protein S30EA Shew185_1265 66 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 152999389 Common - Phosphoribulokinase Shew185_0853 52 COG3954 PrkB, Phosphoribulokinase Energy production and conversion 153002653 Common - hypothetical protein Shew185_4154 1 None None None 153002135 Common - hypothetical protein Shew185_3628 1 None None None 152999288 Common - glycoside hydrolase family 24 Shew185_0749 22 COG3772 COG3772, Phage-related lysozyme (muraminidase) General function prediction only 153001616 Common - hypothetical protein Shew185_3103 5 None None None 153002728 Common - hypothetical protein Shew185_4230 16 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 152999742 Common - hypothetical protein Shew185_1209 1 None None None 153000403 Common - ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Shew185_1878 7 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 152998991 Common - deoxyribodipyrimidine photolyase-related protein Shew185_0441 59 COG3046 COG3046, Uncharacterized protein related to deoxyribodipyrimidine photolyase General function prediction only 152999700 Common - extracellular solute-binding protein family 1 Shew185_1166 132 COG0687 PotD, Spermidine/putrescine-binding periplasmic protein Amino acid transport and metabolism 152999970 Common - flavodoxin/nitric oxide synthase Shew185_1438 78 COG0716 FldA, Flavodoxins Energy production and conversion 153000062 Common - amino acid-binding ACT domain protein Shew185_1532 21 COG2716 GcvR, Glycine cleavage system regulatory protein Amino acid transport and metabolism 152999944 Common - hypothetical protein Shew185_1412 4 None None None 153000933 Common - protein of unknown function DUF1568 Shew185_2414 22 None None None 153001784 Common - Polyribonucleotide nucleotidyltransferase Shew185_3275 242 COG1185 Pnp, Polyribonucleotide nucleotidyltransferase (polynucleotide phosphorylase) Translation, ribosomal structure and biogenesis 153000356 Common - diguanylate cyclase Shew185_1831 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153000103 Common - phage SPO1 DNA polymerase domain protein Shew185_1574 56 COG1573 COG1573, Uracil-DNA glycosylase DNA replication, recombination, and repair 153000686 Common - putative transcriptional regulator, Crp/Fnr family Shew185_2162 158 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 153001657 Common - (p)ppGpp synthetase I, SpoT/RelA Shew185_3144 205 COG0317 SpoT, Guanosine polyphosphate pyrophosphohydrolases/synthetases Signal transduction mechanisms / Transcription 153001415 Common - glucose-1-phosphate thymidylyltransferase Shew185_2899 233 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 153000574 Common - protein of unknown function DUF58 Shew185_2050 35 COG1721 COG1721, Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) General function prediction only 153001089 Common - hypothetical protein Shew185_2572 1 None None None 153002310 Common - Formate--tetrahydrofolate ligase Shew185_3804 89 COG2759 MIS1, Formyltetrahydrofolate synthetase Nucleotide transport and metabolism 153000763 Common - CheD Shew185_2243 87 COG1871 CheD, Chemotaxis protein; stimulates methylation of MCP proteins Cell motility and secretion / Signal transduction mechanisms 152998606 Common - two component transcriptional regulator, winged helix family Shew185_0051 225 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153002145 Common - extracellular solute-binding protein family 3 Shew185_3638 35 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 153000865 Common - Alanine racemase Shew185_2345 127 COG1609 PurR, Transcriptional regulators Transcription 153000437 Common - hydrogenase expression/formation protein Shew185_1912 63 COG0680 HyaD, Ni,Fe-hydrogenase maturation factor Energy production and conversion 153000098 Common - Pyridoxal-dependent decarboxylase Shew185_1569 122 COG0076 GadB, Glutamate decarboxylase and related PLP-dependent proteins Amino acid transport and metabolism 153002306 Common - hypothetical protein Shew185_3800 1 None None None 153001414 Common - dTDP-4-dehydrorhamnose 3,5-epimerase Shew185_2898 167 COG1898 RfbC, dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes Cell envelope biogenesis, outer membrane 153001346 Common - protein of unknown function DUF606 Shew185_2830 58 COG3238 COG3238, Uncharacterized protein conserved in bacteria Function unknown 152998899 Common - Tetratricopeptide TPR_2 repeat protein Shew185_0347 4 None None None 153001246 Common - L-lysine 6-monooxygenase (NADPH) Shew185_2730 52 COG3486 IucD, Lysine/ornithine N-monooxygenase Secondary metabolites biosynthesis, transport, and catabolism 153002873 Common - flavodoxin/nitric oxide synthase Shew185_4377 69 COG0716 FldA, Flavodoxins Energy production and conversion 152999446 Common - sodium/hydrogen exchanger Shew185_0910 136 COG3263 COG3263, NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain Inorganic ion transport and metabolism 152999174 Common - Quinone oxidoreductase putative PIG3 Shew185_0631 200 COG0604 Qor, NADPH:quinone reductase and related Zn-dependent oxidoreductases Energy production and conversion / General function prediction only 153000759 Common - HNH nuclease Shew185_2239 12 COG1403 McrA, Restriction endonuclease Defense mechanisms 153002752 Common - Glutathione S-transferase domain Shew185_4254 66 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 152998686 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Shew185_0133 187 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 153002184 Common - glycine cleavage system T protein Shew185_3677 178 COG0404 GcvT, Glycine cleavage system T protein (aminomethyltransferase) Amino acid transport and metabolism 153001856 Common - ABC transporter related Shew185_3347 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 153001241 Common - Indole-3-glycerol-phosphate synthase, Phosphoribosylanthranilate isomerase Shew185_2725 220 COG0134 TrpC, Indole-3-glycerol phosphate synthase Amino acid transport and metabolism 152998853 Common - aminotransferase class V Shew185_0300 148 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 153000637 Common - excinuclease ABC, B subunit Shew185_2113 229 COG0556 UvrB, Helicase subunit of the DNA excision repair complex DNA replication, recombination, and repair 153000971 Common - dTMP kinase Shew185_2452 228 COG0125 Tmk, Thymidylate kinase Nucleotide transport and metabolism 152998962 Common - periplasmic/7TM domain sensor diguanylate cyclase Shew185_0411 179 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153001449 Common - flagellar protein export ATPase FliI Shew185_2933 247 COG1157 FliI, Flagellar biosynthesis/type III secretory pathway ATPase Cell motility and secretion / Intracellular trafficking and secretion 153000646 Common - SEC-C motif domain protein Shew185_2122 88 COG3012 COG3012, Uncharacterized protein conserved in bacteria Function unknown 152998785 Common - periplasmic protein thiol--disulphide oxidoreductase DsbE Shew185_0232 129 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 153001664 Common - DNA repair protein RecN Shew185_3151 203 COG0497 RecN, ATPase involved in DNA repair DNA replication, recombination, and repair 152998957 Common - UDP-3-0-acyl N-acetylglucosamine deacetylase Shew185_0406 139 COG0774 LpxC, UDP-3-O-acyl-N-acetylglucosamine deacetylase Cell envelope biogenesis, outer membrane 152998671 Common - Lysine exporter protein (LYSE/YGGA) Shew185_0118 104 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 153000246 Common - 6-phosphogluconate dehydrogenase NAD-binding Shew185_1721 197 COG2084 MmsB, 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases Lipid metabolism 153001917 Nonpathogen - response regulator receiver protein Shew185_3408 15 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152998725 Common - Rhodanese domain protein Shew185_0172 65 COG2603 COG2603, Predicted ATPase General function prediction only 153001670 Common - riboflavin synthase, alpha subunit Shew185_3158 209 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 152998588 Common - Coproporphyrinogen oxidase Shew185_0033 113 COG0408 HemF, Coproporphyrinogen III oxidase Coenzyme metabolism 153001973 Common - hypothetical protein Shew185_3464 21 COG3591 COG3591, V8-like Glu-specific endopeptidase Amino acid transport and metabolism 153002504 Common - import inner membrane translocase subunit Tim44 Shew185_4001 39 COG4395 COG4395, Uncharacterized protein conserved in bacteria Function unknown 152998781 Common - heme exporter protein CcmA Shew185_0228 249 COG4133 CcmA, ABC-type transport system involved in cytochrome c biogenesis, ATPase component Posttranslational modification, protein turnover, chaperones 152998925 Common - deoxyuridine 5'-triphosphate nucleotidohydrolase Dut Shew185_0374 179 COG0756 Dut, dUTPase Nucleotide transport and metabolism 153001456 Common - sigma54 specific transcriptional regulator, Fis family Shew185_2940 170 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153002038 Common - acriflavin resistance protein Shew185_3529 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 153002372 Common - Endothelin-converting enzyme 1 Shew185_3866 63 COG3590 PepO, Predicted metalloendopeptidase Posttranslational modification, protein turnover, chaperones 152999223 Common - PTS IIA-like nitrogen-regulatory protein PtsN Shew185_0684 134 COG1762 PtsN, Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) Carbohydrate transport and metabolism / Signal transduction mechanisms 152999131 Common - Ig domain protein group 1 domain protein Shew185_0587 6 None None None 153001563 Common - Glutaminase Shew185_3050 72 COG2066 GlsA, Glutaminase Amino acid transport and metabolism 153001686 Common - helix-turn-helix- domain containing protein AraC type Shew185_3174 133 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 153002646 Common - putative signal transduction protein Shew185_4147 62 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 153002550 Common - helix-turn-helix- domain containing protein AraC type Shew185_4050 63 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 153001238 Common - anthranilate synthase component I Shew185_2722 222 COG0147 TrpE, Anthranilate/para-aminobenzoate synthases component I Amino acid transport and metabolism / Coenzyme metabolism 153002353 Common - heavy metal efflux pump, CzcA family Shew185_3847 177 COG3696 COG3696, Putative silver efflux pump Inorganic ion transport and metabolism 153000926 Common - S-formylglutathione hydrolase Shew185_2407 99 COG0627 COG0627, Predicted esterase General function prediction only 152999291 Common - phage DNA packaging Nu1 Shew185_0752 5 COG4220 COG4220, Phage DNA packaging protein, Nu1 subunit of terminase DNA replication, recombination, and repair 153002228 Nonpathogen - hypothetical protein Shew185_3722 1 None None None 153000206 Common - Cytidine deaminase Shew185_1679 32 COG0295 Cdd, Cytidine deaminase Nucleotide transport and metabolism 152998723 Common - transcriptional regulator, TetR family Shew185_0170 34 COG1309 AcrR, Transcriptional regulator Transcription 153001262 Common - aldehyde oxidase and xanthine dehydrogenase molybdopterin binding Shew185_2746 102 COG1529 CoxL, Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs Energy production and conversion 153001307 Common - membrane protein involved in aromatic hydrocarbon degradation Shew185_2791 72 COG2067 FadL, Long-chain fatty acid transport protein Lipid metabolism 153001791 Common - protein of unknown function DUF150 Shew185_3282 181 COG0779 COG0779, Uncharacterized protein conserved in bacteria Function unknown 152999198 Common - thioredoxin domain protein Shew185_0658 15 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 152999199 Common - putative cold-shock DNA-binding domain protein Shew185_0659 20 COG1278 CspC, Cold shock proteins Transcription 152999983 Common - 1-deoxy-D-xylulose 5-phosphate reductoisomerase Shew185_1451 184 COG0743 Dxr, 1-deoxy-D-xylulose 5-phosphate reductoisomerase Lipid metabolism 153000191 Common - phosphate-starvation-inducible E Shew185_1664 7 COG3223 COG3223, Predicted membrane protein Function unknown 153000174 Common - Alcohol dehydrogenase zinc-binding domain protein Shew185_1647 141 COG2130 COG2130, Putative NADP-dependent oxidoreductases General function prediction only 153000730 Common - DsrC family protein Shew185_2209 60 COG2920 DsrC, Dissimilatory sulfite reductase (desulfoviridin), gamma subunit Inorganic ion transport and metabolism 153000503 Common - restriction modification system DNA specificity domain protein Shew185_1978 94 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 152998590 Common - shikimate 5-dehydrogenase Shew185_0035 223 COG0169 AroE, Shikimate 5-dehydrogenase Amino acid transport and metabolism 153002420 Common - phosphoribosylamine--glycine ligase Shew185_3914 231 COG0151 PurD, Phosphoribosylamine-glycine ligase Nucleotide transport and metabolism 153000625 Common - hypothetical protein Shew185_2101 2 None None None 153002818 Common - molybdenum cofactor biosynthesis protein A Shew185_4322 196 COG2896 MoaA, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 152999324 Common - protein of unknown function UPF0227 Shew185_0785 49 COG3150 COG3150, Predicted esterase General function prediction only 153001587 Common - transglutaminase domain protein Shew185_3074 28 COG1305 COG1305, Transglutaminase-like enzymes, putative cysteine proteases Amino acid transport and metabolism 152999848 Common - putative transporter, BCCT family protein Shew185_1316 74 COG1292 BetT, Choline-glycine betaine transporter Cell envelope biogenesis, outer membrane 153001362 Common - acyl-CoA dehydrogenase domain protein Shew185_2846 168 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 152999536 Common - integral membrane sensor signal transduction histidine kinase Shew185_1002 211 COG5000 NtrY, Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation Signal transduction mechanisms 153001572 Common - hypothetical protein Shew185_3059 1 None None None 152999238 Common - periplasmic serine protease DegS Shew185_0699 222 COG0265 DegQ, Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain Posttranslational modification, protein turnover, chaperones 153000278 Common - Methyltransferase type 11 Shew185_1753 61 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153000312 Common - cytochrome B561 Shew185_1787 49 COG3658 COG3658, Cytochrome b Energy production and conversion 152999831 Common - cyclase/dehydrase Shew185_1299 102 COG2867 COG2867, Oligoketide cyclase/lipid transport protein Lipid metabolism 152999118 Nonpathogen - Domain of unknown function DUF1835 Shew185_0571 1 None None None 153002365 Common - UbiD family decarboxylase Shew185_3859 154 COG0043 UbiD, 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases Coenzyme metabolism 153001334 Common - DEAD/DEAH box helicase domain protein Shew185_2818 239 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 152999709 Common - hypothetical protein Shew185_1175 6 None None None 153000162 Common - RNA-binding S4 domain protein Shew185_1635 59 COG2501 COG2501, Uncharacterized conserved protein Function unknown 153000422 Common - lytic murein transglycosylase Shew185_1897 99 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 152999007 Common - sulphate transporter Shew185_0457 19 COG0659 SUL1, Sulfate permease and related transporters (MFS superfamily) Inorganic ion transport and metabolism 152999040 Common - MSHA pilin protein MshB Shew185_0490 7 COG2165 PulG, Type II secretory pathway, pseudopilin PulG Cell motility and secretion / Intracellular trafficking and secretion 152999233 Common - Mammalian cell entry related domain protein Shew185_0694 79 COG1463 Ttg2C, ABC-type transport system involved in resistance to organic solvents, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 153002847 Common - oxygen-independent coproporphyrinogen III oxidase Shew185_4351 203 COG0635 HemN, Coproporphyrinogen III oxidase and related Fe-S oxidoreductases Coenzyme metabolism 152998776 Common - hypothetical protein Shew185_0223 21 COG2984 COG2984, ABC-type uncharacterized transport system, periplasmic component General function prediction only 152999912 Common - hypothetical protein Shew185_1380 37 COG5587 COG5587, Uncharacterized conserved protein Function unknown 152999753 Common - Adenosylhomocysteine nucleosidase Shew185_1220 107 COG0775 Pfs, Nucleoside phosphorylase Nucleotide transport and metabolism 153002765 Common - DNA-directed DNA polymerase Shew185_4268 162 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 152998735 Common - translation elongation factor Tu Shew185_0182 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 153000984 Common - ATP-dependent Clp protease, ATP-binding subunit clpA Shew185_2465 221 COG0542 ClpA, ATPases with chaperone activity, ATP-binding subunit Posttranslational modification, protein turnover, chaperones 153002596 Common - protein of unknown function DUF1439 Shew185_4097 21 None None None 152998596 Common - carboxyl-terminal protease Shew185_0041 181 COG0793 Prc, Periplasmic protease Cell envelope biogenesis, outer membrane 152998625 Common - ABC transporter related Shew185_0070 249 COG4555 NatA, ABC-type Na+ transport system, ATPase component Energy production and conversion / Inorganic ion transport and metabolism 152998984 Common - hypothetical protein Shew185_0434 1 None None None 153002840 Common - ThiJ/PfpI domain protein Shew185_4344 38 COG3155 ElbB, Uncharacterized protein involved in an early stage of isoprenoid biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 152999128 Common - type II secretion system protein Shew185_0582 5 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 153001543 Common - protein of unknown function UPF0126 Shew185_3030 132 COG2860 COG2860, Predicted membrane protein Function unknown 153000149 Common - porin Gram-negative type Shew185_1620 23 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 153000325 Common - nitroreductase Shew185_1800 89 COG0778 NfnB, Nitroreductase Energy production and conversion 153000546 Common - hypothetical protein Shew185_2021 17 None None None 153002244 Common - hypothetical protein Shew185_3738 8 None None None 152999316 Common - Enoyl-CoA hydratase/isomerase Shew185_0777 163 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 153002684 Common - hypothetical protein Shew185_4186 28 None None None 153002290 Common - Thiopurine S-methyltransferase Shew185_3784 27 None None None 153000152 Common - hypothetical protein Shew185_1625 18 None None None 153001297 Common - acetyl-CoA C-acyltransferase FadI Shew185_2781 175 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 153000367 Common - excisionase, putative Shew185_1842 4 None None None 153002521 Common - protein of unknown function DUF523 Shew185_4019 76 COG1683 COG1683, Uncharacterized conserved protein Function unknown 153000266 Common - Tol-Pal system TolA Shew185_1741 16 COG3064 TolA, Membrane protein involved in colicin uptake Cell envelope biogenesis, outer membrane 153000723 Nonpathogen - hypothetical protein Shew185_2202 2 None None None 153000319 Common - TonB-dependent receptor Shew185_1794 103 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 153002475 Common - protein of unknown function DUF484 Shew185_3972 51 COG3159 COG3159, Uncharacterized protein conserved in bacteria Function unknown 152998611 Common - major facilitator superfamily MFS_1 Shew185_0056 78 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 152998640 Common - 2,3-diketo-5-methylthio-1-phosphopentane phosphatase Shew185_0085 31 COG4229 COG4229, Predicted enolase-phosphatase Energy production and conversion 152999802 Common - hypothetical protein Shew185_1269 2 None None None 153000521 Common - glucose-methanol-choline oxidoreductase Shew185_1996 64 COG2303 BetA, Choline dehydrogenase and related flavoproteins Amino acid transport and metabolism 153001844 Common - SSS sodium solute transporter superfamily Shew185_3335 161 COG4146 COG4146, Predicted symporter General function prediction only 153000862 Common - DNA-directed DNA polymerase Shew185_2342 182 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 153000124 Common - ATP-dependent protease La Shew185_1595 217 COG0466 Lon, ATP-dependent Lon protease, bacterial type Posttranslational modification, protein turnover, chaperones 153001226 Common - hypothetical protein Shew185_2710 3 None None None 153002350 Common - transcriptional regulator, LysR family Shew185_3844 185 COG0583 LysR, Transcriptional regulator Transcription 153001741 Common - nucleoside transporter Shew185_3232 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 153000630 Common - hypothetical protein Shew185_2106 3 None None None 152998971 Common - Arginase/agmatinase/formiminoglutamase Shew185_0420 24 COG0010 SpeB, Arginase/agmatinase/formimionoglutamate hydrolase, arginase family Amino acid transport and metabolism 153000041 Common - hypothetical protein Shew185_1511 4 None None None 153001466 Common - flagellar hook-associated protein FlgK Shew185_2953 124 COG1256 FlgK, Flagellar hook-associated protein Cell motility and secretion 153000111 Common - cytochrome C family protein Shew185_1582 36 None None None 153001952 Common - 2OG-Fe(II) oxygenase Shew185_3443 36 COG3145 AlkB, Alkylated DNA repair protein DNA replication, recombination, and repair 152998819 Common - methyl-accepting chemotaxis sensory transducer Shew185_0266 151 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153000822 Common - TonB-dependent receptor plug Shew185_2302 114 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 153000897 Common - Nucleoside-diphosphate kinase Shew185_2377 230 COG0105 Ndk, Nucleoside diphosphate kinase Nucleotide transport and metabolism 153002635 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Shew185_4136 182 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 153002663 Common - putative methyltransferase Shew185_4165 208 COG0742 COG0742, N6-adenine-specific methylase DNA replication, recombination, and repair 153000851 Common - alkylhydroperoxidase like protein, AhpD family Shew185_2331 80 COG2128 COG2128, Uncharacterized conserved protein Function unknown 152999637 Common - phosphoribosylaminoimidazole carboxylase, catalytic subunit Shew185_1103 233 COG0041 PurE, Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase Nucleotide transport and metabolism 153000078 Common - 3-beta hydroxysteroid dehydrogenase/isomerase Shew185_1549 137 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153001727 Common - two component transcriptional regulator, winged helix family Shew185_3217 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153002315 Common - hypothetical protein Shew185_3809 5 None None None 152998794 Common - diheme cytochrome c Shew185_0241 17 None None None 153001353 Common - short-chain dehydrogenase/reductase SDR Shew185_2837 233 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153001147 Common - lytic murein transglycosylase Shew185_2630 105 COG2951 MltB, Membrane-bound lytic murein transglycosylase B Cell envelope biogenesis, outer membrane 153001919 Common - chaperone protein DnaJ Shew185_3410 233 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 152999900 Common - Glutathione peroxidase Shew185_1368 115 COG0386 BtuE, Glutathione peroxidase Posttranslational modification, protein turnover, chaperones 153001983 Common - WD-40 repeat protein Shew185_3474 45 COG2319 COG2319, FOG: WD40 repeat General function prediction only 152999689 Common - outer membrane porin Shew185_1155 7 None None None 152999737 Common - glutamate-1-semialdehyde-2,1-aminomutase Shew185_1204 237 COG0001 HemL, Glutamate-1-semialdehyde aminotransferase Coenzyme metabolism 153002795 Nonpathogen - hypothetical protein Shew185_4299 4 None None None 153001802 Common - hypothetical protein Shew185_3293 3 None None None 152998906 Common - hypothetical protein Shew185_0354 2 None None None 153002455 Common - thioredoxin Shew185_3952 233 COG3118 COG3118, Thioredoxin domain-containing protein Posttranslational modification, protein turnover, chaperones 153001713 Common - protein of unknown function UPF0016 Shew185_3202 52 COG2119 COG2119, Predicted membrane protein Function unknown 152998586 Common - DNA topoisomerase type IA zn finger domain protein Shew185_0031 149 COG0551 TopA, Zn-finger domain associated with topoisomerase type I DNA replication, recombination, and repair 153002448 Common - dephospho-CoA kinase Shew185_3945 210 COG0237 CoaE, Dephospho-CoA kinase Coenzyme metabolism 152998812 Common - signal transduction histidine kinase, nitrogen specific, NtrB Shew185_0259 219 COG3852 NtrB, Signal transduction histidine kinase, nitrogen specific Signal transduction mechanisms 152999073 Common - OmpA domain protein transmembrane region-containing protein Shew185_0523 34 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 153000169 Common - hypothetical protein Shew185_1642 1 None None None 153000549 Common - hypothetical protein Shew185_2024 2 None None None 153001814 Common - protein of unknown function UPF0054 Shew185_3305 199 COG0319 COG0319, Predicted metal-dependent hydrolase General function prediction only 153000771 Common - methyl-accepting chemotaxis sensory transducer Shew185_2251 19 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153002104 Common - Uncharacterized lipoprotein Shew185_3597 18 COG3056 COG3056, Uncharacterized lipoprotein Cell envelope biogenesis, outer membrane 153001798 Common - ribosomal RNA methyltransferase RrmJ/FtsJ Shew185_3289 138 COG0293 FtsJ, 23S rRNA methylase Translation, ribosomal structure and biogenesis 152999355 Common - diguanylate cyclase Shew185_0819 182 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153000471 Common - GCN5-related N-acetyltransferase Shew185_1946 9 COG0456 RimI, Acetyltransferases General function prediction only 153001396 Common - protein of unknown function DUF940 membrane lipoprotein putative Shew185_2880 22 None None None 153001151 Common - Methyltransferase type 11 Shew185_2634 166 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 152999810 Common - OsmC family protein Shew185_1278 43 COG1764 OsmC, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 152998842 Common - diguanylate cyclase Shew185_0289 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153000136 Common - phage shock B family protein Shew185_1607 23 None None None 153000565 Common - Fmu (Sun) domain protein Shew185_2041 208 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 153001179 Common - GCN5-related N-acetyltransferase Shew185_2662 57 COG0456 RimI, Acetyltransferases General function prediction only 153002211 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Shew185_3704 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 153001561 Common - transcriptional regulator, LysR family Shew185_3048 167 COG0583 LysR, Transcriptional regulator Transcription 153002116 Common - protein of unknown function DUF819 Shew185_3609 21 COG5505 COG5505, Predicted integral membrane protein Function unknown 153001061 Common - hypothetical protein Shew185_2543 2 None None None 152998883 Common - hypothetical protein Shew185_0331 73 COG4258 COG4258, Predicted exporter General function prediction only 153000373 Common - hypothetical protein Shew185_1848 1 None None None 153000857 Common - Glucan 1,4-alpha-glucosidase Shew185_2337 26 COG3387 SGA1, Glucoamylase and related glycosyl hydrolases Carbohydrate transport and metabolism 153001103 Common - heat shock protein Hsp90 Shew185_2586 150 COG0326 HtpG, Molecular chaperone, HSP90 family Posttranslational modification, protein turnover, chaperones 153001847 Common - glycoside hydrolase family 2 sugar binding Shew185_3338 74 COG3250 LacZ, Beta-galactosidase/beta-glucuronidase Carbohydrate transport and metabolism 152998618 Common - TonB-dependent receptor Shew185_0063 40 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 153001766 Common - putative replication protein Shew185_3257 17 None None None 153001429 Common - Cobyrinic acid ac-diamide synthase Shew185_2913 229 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 153001823 Common - nicotinate (nicotinamide) nucleotide adenylyltransferase Shew185_3314 187 COG1057 NadD, Nicotinic acid mononucleotide adenylyltransferase Coenzyme metabolism 152999416 Common - delta-1-pyrroline-5-carboxylate dehydrogenase Shew185_0880 220 COG4230 COG4230, Delta 1-pyrroline-5-carboxylate dehydrogenase Energy production and conversion 153002220 Common - uncharacterised conserved protein UCP006287 Shew185_3714 22 COG3112 COG3112, Uncharacterized protein conserved in bacteria Function unknown 152998564 Common - glycyl-tRNA synthetase, alpha subunit Shew185_0009 167 COG0752 GlyQ, Glycyl-tRNA synthetase, alpha subunit Translation, ribosomal structure and biogenesis 152999931 Common - helix-turn-helix- domain containing protein AraC type Shew185_1399 125 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 153000384 Common - replication P family protein Shew185_1859 8 None None None 153001156 Common - hypothetical protein Shew185_2639 6 None None None 153001442 Common - flagellar biosynthetic protein FliP Shew185_2926 128 COG1338 FliP, Flagellar biosynthesis pathway, component FliP Cell motility and secretion / Intracellular trafficking and secretion 153001172 Common - Maltose O-acetyltransferase Shew185_2655 183 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 152999525 Common - GCN5-related N-acetyltransferase Shew185_0990 74 COG0456 RimI, Acetyltransferases General function prediction only 153000023 Common - acyl-CoA dehydrogenase domain protein Shew185_1491 162 COG1960 CaiA, Acyl-CoA dehydrogenases Lipid metabolism 152999097 Common - TonB family protein Shew185_0547 15 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 153001775 Common - hypothetical protein Shew185_3266 1 None None None 153001768 Nonpathogen - hypothetical protein Shew185_3259 1 None None None 153002500 Common - phosphoesterase PA-phosphatase related Shew185_3997 36 COG0671 PgpB, Membrane-associated phospholipid phosphatase Lipid metabolism 152998718 Common - phage Tail Collar domain protein Shew185_0165 38 COG4675 MdpB, Microcystin-dependent protein Function unknown 153000122 Common - ATP-dependent Clp protease, proteolytic subunit ClpP Shew185_1593 211 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 153000516 Common - Domain of unknown function DUF1814 Shew185_1991 20 COG2253 COG2253, Uncharacterized conserved protein Function unknown 152999677 Common - Beta-N-acetylhexosaminidase Shew185_1143 42 COG3525 Chb, N-acetyl-beta-hexosaminidase Carbohydrate transport and metabolism 153001369 Nonpathogen - hypothetical protein Shew185_2853 1 None None None 152999487 Common - hypothetical protein Shew185_0952 1 None None None 153002176 Common - transcriptional regulator, LysR family Shew185_3669 185 COG0583 LysR, Transcriptional regulator Transcription 153001875 Common - putative replication protein Shew185_3366 17 None None None 153000185 Common - two component transcriptional regulator, LytTR family Shew185_1658 205 COG3279 LytT, Response regulator of the LytR/AlgR family Transcription / Signal transduction mechanisms 153002322 Common - response regulator receiver protein Shew185_3816 174 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153000463 Common - periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family Shew185_1938 46 COG3005 TorC, Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit Energy production and conversion 153000339 Common - hypothetical protein Shew185_1814 2 None None None 153001912 Common - peptidylprolyl isomerase FKBP-type Shew185_3403 133 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 153001959 Common - cytochrome d ubiquinol oxidase, subunit II Shew185_3450 149 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 153002626 Common - hypothetical protein Shew185_4127 1 None None None 153000919 Common - hypothetical protein Shew185_2399 23 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 153002380 Common - formate-dependent nitrite reductase, NrfG protein Shew185_3874 19 COG4235 COG4235, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 152999455 Common - sulfite reductase (NADPH) flavoprotein, alpha chain Shew185_0919 103 COG0369 CysJ, Sulfite reductase, alpha subunit (flavoprotein) Inorganic ion transport and metabolism 153001944 Common - NADH:ubiquinone oxidoreductase, subunit D Shew185_3435 76 COG1347 NqrD, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrD Energy production and conversion 153002519 Common - phospholipid/glycerol acyltransferase Shew185_4017 29 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 153000885 Common - hypothetical protein Shew185_2365 1 None None None 153002242 Common - molydopterin dinucleotide-binding region Shew185_3736 77 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 152999276 Common - GCN5-related N-acetyltransferase Shew185_0737 14 COG0456 RimI, Acetyltransferases General function prediction only 153000890 Common - Lysine exporter protein (LYSE/YGGA) Shew185_2370 53 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 152999864 Common - multi antimicrobial extrusion protein MatE Shew185_1332 141 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 153000754 Nonpathogen - putative transcriptional regulator, XRE family Shew185_2233 3 COG1396 HipB, Predicted transcriptional regulators Transcription 152999300 Common - hypothetical protein Shew185_0761 6 None None None 153002335 Common - major facilitator superfamily MFS_1 Shew185_3829 30 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153001020 Common - Silent information regulator protein Sir2 Shew185_2501 148 COG0846 SIR2, NAD-dependent protein deacetylases, SIR2 family Transcription 153001321 Common - protein-export membrane protein SecD Shew185_2805 212 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 153001535 Common - diguanylate cyclase Shew185_3022 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153000907 Common - transcriptional regulator, BadM/Rrf2 family Shew185_2387 170 COG1959 COG1959, Predicted transcriptional regulator Transcription 153001705 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Shew185_3193 116 COG1143 NuoI, Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) Energy production and conversion 153002205 Common - Phosphoglycerate mutase Shew185_3698 8 COG0406 GpmB, Fructose-2,6-bisphosphatase Carbohydrate transport and metabolism 152999771 Common - L-aspartate oxidase Shew185_1238 226 COG0029 NadB, Aspartate oxidase Coenzyme metabolism 153002384 Common - cytochrome c-type biogenesis protein CcmF Shew185_3878 135 COG1138 CcmF, Cytochrome c biogenesis factor Posttranslational modification, protein turnover, chaperones 152999203 Common - hypothetical protein Shew185_0663 12 None None None 153001483 Common - hypothetical protein Shew185_2970 11 None None None 152999331 Common - integral membrane sensor signal transduction histidine kinase Shew185_0792 213 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 153001515 Common - Pyrrolo-quinoline quinone Shew185_3002 112 COG1520 COG1520, FOG: WD40-like repeat Function unknown 152998638 Common - Carboxymuconolactone decarboxylase Shew185_0083 95 COG0599 COG0599, Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit Function unknown 152999375 Common - hypothetical protein Shew185_0839 40 COG3647 COG3647, Predicted membrane protein Function unknown 153001027 Common - 2-oxoglutarate dehydrogenase, E1 subunit Shew185_2508 147 COG0567 SucA, 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes Energy production and conversion 153001860 Common - HipA domain protein Shew185_3351 51 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 152998605 Common - TrkA-N domain protein Shew185_0050 91 COG0569 TrkA, K+ transport systems, NAD-binding component Inorganic ion transport and metabolism 152999909 Common - Glutathione S-transferase domain Shew185_1377 104 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 153000478 Common - GP46 Shew185_1953 7 None None None 153002392 Common - protein of unknown function UPF0118 Shew185_3886 124 COG0628 PerM, Predicted permease General function prediction only 152999338 Common - transcriptional regulator, ModE family Shew185_0799 71 COG2005 ModE, N-terminal domain of molybdenum-binding protein General function prediction only 153000912 Common - lipoprotein releasing system, ATP-binding protein Shew185_2392 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 153002081 Common - TonB-dependent receptor plug Shew185_3573 92 COG4206 BtuB, Outer membrane cobalamin receptor protein Coenzyme metabolism 153002276 Common - N-acetylmuramoyl-L-alanine amidase Shew185_3770 165 COG0860 AmiC, N-acetylmuramoyl-L-alanine amidase Cell envelope biogenesis, outer membrane 153000716 Common - restriction modification system DNA specificity domain protein Shew185_2194 96 COG0732 HsdS, Restriction endonuclease S subunits Defense mechanisms 152998566 Common - amidohydrolase Shew185_0011 169 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 152999593 Common - phosphoribosylglycinamide formyltransferase 2 Shew185_1059 202 COG0027 PurT, Formate-dependent phosphoribosylglycinamide formyltransferase (GAR transformylase) Nucleotide transport and metabolism 153002371 Common - fatty acid cistrans isomerase Shew185_3865 15 None None None 152998703 Common - general secretory pathway protein E Shew185_0150 220 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 152999077 Common - Phosphoribosylaminoimidazole-succinocarboxamide synthase Shew185_0527 104 COG0152 PurC, Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase Nucleotide transport and metabolism 153001731 Common - alpha/beta hydrolase fold Shew185_3222 12 COG2267 PldB, Lysophospholipase Lipid metabolism 153002183 Common - glycine cleavage system H protein Shew185_3676 187 COG0509 GcvH, Glycine cleavage system H protein (lipoate-binding) Amino acid transport and metabolism 152999582 Common - SurA domain protein Shew185_1048 161 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 153001647 Common - 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Shew185_3134 187 COG1211 IspD, 4-diphosphocytidyl-2-methyl-D-erithritol synthase Lipid metabolism 153000411 Common - peptidase M22 glycoprotease Shew185_1886 187 COG1214 COG1214, Inactive homolog of metal-dependent proteases, putative molecular chaperone Posttranslational modification, protein turnover, chaperones 153002160 Common - hypoxanthine-guanine phosphoribosyltransferase Shew185_3653 36 COG2236 COG2236, Predicted phosphoribosyltransferases General function prediction only 153000447 Common - periplasmic glucan biosynthesis protein MdoG Shew185_1922 50 COG3131 MdoG, Periplasmic glucans biosynthesis protein Inorganic ion transport and metabolism 152998915 Common - ERCC4 domain protein Shew185_0363 40 COG1948 MUS81, ERCC4-type nuclease DNA replication, recombination, and repair 152999496 Common - MORN variant repeat protein Shew185_0961 18 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 152999686 Common - aminotransferase class-III Shew185_1152 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 153002003 Common - methyl-accepting chemotaxis sensory transducer Shew185_3494 155 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152999739 Common - Chloride channel core Shew185_1206 161 COG0038 EriC, Chloride channel protein EriC Inorganic ion transport and metabolism 153002378 Common - Polysulphide reductase NrfD Shew185_3872 21 COG3301 NrfD, Formate-dependent nitrite reductase, membrane component Inorganic ion transport and metabolism 152999933 Common - TonB-dependent receptor plug Shew185_1401 48 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 153000698 Common - phage integrase family protein Shew185_2174 25 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 153002072 Common - NADH:ubiquinone oxidoreductase, subunit A Shew185_3564 40 COG1726 NqrA, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrA Energy production and conversion 152999907 Common - hypothetical protein Shew185_1375 1 None None None 152999785 Common - cytochrome c assembly protein Shew185_1252 63 COG4137 COG4137, ABC-type uncharacterized transport system, permease component General function prediction only 153001388 Common - transferase hexapeptide repeat containing protein Shew185_2872 218 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 153000147 Common - helicase c2 Shew185_1618 132 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 153002046 Common - fructose-bisphosphate aldolase, class II, Calvin cycle subtype Shew185_3537 176 COG0191 Fba, Fructose/tagatose bisphosphate aldolase Carbohydrate transport and metabolism 153001232 Common - hypothetical protein Shew185_2716 3 None None None 153001372 Common - protein of unknown function DUF81 Shew185_2856 96 COG0730 COG0730, Predicted permeases General function prediction only 153002577 Common - Ribulose-phosphate 3-epimerase Shew185_4077 216 COG0036 Rpe, Pentose-5-phosphate-3-epimerase Carbohydrate transport and metabolism 153001796 Common - hypothetical protein Shew185_3287 1 None None None 153002255 Common - two component transcriptional regulator, winged helix family Shew185_3749 224 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152999796 Common - sodium/hydrogen exchanger Shew185_1263 122 COG0025 NhaP, NhaP-type Na+/H+ and K+/H+ antiporters Inorganic ion transport and metabolism 153002512 Common - acetolactate synthase, large subunit, biosynthetic type Shew185_4009 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 152998711 Common - General secretion pathway M protein Shew185_0158 23 COG3149 PulM, Type II secretory pathway, component PulM Intracellular trafficking and secretion 153001804 Common - hypothetical protein Shew185_3295 27 COG5266 CbiK, ABC-type Co2+ transport system, periplasmic component Inorganic ion transport and metabolism 153001206 Common - formate/nitrite transporter Shew185_2689 92 COG2116 FocA, Formate/nitrite family of transporters Inorganic ion transport and metabolism 152999919 Common - fumarylacetoacetate (FAA) hydrolase Shew185_1387 177 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 152999142 Nonpathogen - hypothetical protein Shew185_0599 1 None None None 153001990 Common - diguanylate cyclase with PAS/PAC sensor Shew185_3481 182 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153001235 Common - chromosome segregation and condensation protein ScpA Shew185_2719 141 COG1354 COG1354, Uncharacterized conserved protein Function unknown 153000802 Common - Aspartate transaminase Shew185_2282 73 COG1448 TyrB, Aspartate/tyrosine/aromatic aminotransferase Amino acid transport and metabolism 153000113 Common - ferrous iron transport protein B Shew185_1584 167 COG0370 FeoB, Fe2+ transport system protein B Inorganic ion transport and metabolism 153000608 Common - zinc finger-related protein Shew185_2084 1 None None None 152999385 Common - transcriptional regulator, TraR/DksA family Shew185_0849 146 COG1734 DksA, DnaK suppressor protein Signal transduction mechanisms 152999663 Common - type IV pilus biogenesis protein PilE Shew185_1129 63 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 153000701 Common - Integrase catalytic region Shew185_2177 11 None None None 152999959 Common - hypothetical protein Shew185_1427 12 COG5595 COG5595, Zn-ribbon-containing, possibly nucleic-acid-binding protein General function prediction only 153002198 Common - ABC transporter related Shew185_3691 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 153001729 Common - DNA repair protein RadA Shew185_3219 207 COG1066 Sms, Predicted ATP-dependent serine protease Posttranslational modification, protein turnover, chaperones 152999728 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Shew185_1195 120 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 153001433 Common - chemotaxis phosphatase, CheZ Shew185_2917 47 COG3143 CheZ, Chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153002330 Common - hypothetical protein Shew185_3824 14 None None None 152999308 Common - hypothetical protein Shew185_0769 1 None None None 153001720 Common - Xanthine/uracil/vitamin C permease Shew185_3210 134 COG2252 COG2252, Permeases General function prediction only 152999730 Common - ribosomal RNA large subunit methyltransferase A, putative Shew185_1197 54 None None None 153000210 Common - putative transposase Shew185_1684 31 None None None 153002657 Common - O-succinylbenzoate-CoA synthase Shew185_4159 43 COG1441 MenC, O-succinylbenzoate synthase Coenzyme metabolism 152999881 Common - hypothetical protein Shew185_1349 1 None None None 153000718 Common - protein of unknown function DUF262 Shew185_2196 7 None None None 153000496 Common - replication P family protein Shew185_1971 8 None None None 153001052 Common - transcriptional regulator, TetR family Shew185_2533 9 COG1309 AcrR, Transcriptional regulator Transcription 152999587 Common - hypothetical protein Shew185_1053 5 None None None 152998820 Common - protein of unknown function DUF323 Shew185_0267 85 COG1262 COG1262, Uncharacterized conserved protein Function unknown 152998973 Common - uroporphyrinogen decarboxylase Shew185_0422 12 None None None 153000334 Common - hypothetical protein Shew185_1809 4 COG4984 COG4984, Predicted membrane protein Function unknown 153002675 Common - Glycerol-3-phosphate O-acyltransferase Shew185_4177 48 COG2937 PlsB, Glycerol-3-phosphate O-acyltransferase Lipid metabolism 153000975 Common - uridine kinase Shew185_2456 83 COG0572 Udk, Uridine kinase Nucleotide transport and metabolism 152999679 Common - Glutamine--fructose-6-phosphate transaminase (isomerizing) Shew185_1145 235 COG2222 AgaS, Predicted phosphosugar isomerases Cell envelope biogenesis, outer membrane 153001718 Common - phospholipid/glycerol acyltransferase Shew185_3208 63 COG3176 COG3176, Putative hemolysin General function prediction only 152999298 Nonpathogen - hypothetical protein Shew185_0759 1 None None None 153001078 Common - hypothetical protein Shew185_2561 2 None None None 153001287 Common - Smr protein/MutS2 Shew185_2771 75 COG2840 COG2840, Uncharacterized protein conserved in bacteria Function unknown 152999463 Common - uroporphyrin-III C-methyltransferase Shew185_0927 203 COG0007 CysG, Uroporphyrinogen-III methylase Coenzyme metabolism 152999823 Common - Conserved hypothetical protein CHP02922 Shew185_1291 2 None None None 153000392 Common - type II secretion system protein E Shew185_1867 207 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 152999604 Common - integral membrane sensor signal transduction histidine kinase Shew185_1070 222 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153000043 Common - secretion protein HlyD family protein Shew185_1513 116 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 153000452 Common - ribosomal protein L25 Shew185_1927 140 COG1825 RplY, Ribosomal protein L25 (general stress protein Ctc) Translation, ribosomal structure and biogenesis 153000488 Nonpathogen - hypothetical protein Shew185_1963 2 None None None 153001838 Common - TonB-dependent siderophore receptor Shew185_3329 120 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 152999470 Common - hypothetical protein Shew185_0934 8 None None None 153000737 Common - putative transcriptional regulator, AsnC family Shew185_2216 159 COG1522 Lrp, Transcriptional regulators Transcription 152999249 Common - protein of unknown function DUF481 Shew185_0710 32 COG3137 COG3137, Putative salt-induced outer membrane protein Cell envelope biogenesis, outer membrane 153000596 Common - hypothetical protein Shew185_2072 1 None None None 152998677 Common - peptidase M6 immune inhibitor A Shew185_0124 42 COG4412 COG4412, Uncharacterized protein conserved in bacteria Function unknown 153000681 Common - protein of unknown function UPF0052 and CofD Shew185_2157 90 COG0391 COG0391, Uncharacterized conserved protein Function unknown 152999886 Common - Isocitrate dehydrogenase (NAD(+)) Shew185_1354 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 153002360 Common - 3-dehydroquinate dehydratase, type II Shew185_3854 169 COG0757 AroQ, 3-dehydroquinate dehydratase II Amino acid transport and metabolism 153002415 Common - pseudouridine synthase Shew185_3909 200 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 153001711 Common - nucleoside recognition domain protein Shew185_3199 20 COG3314 COG3314, Uncharacterized protein conserved in bacteria Function unknown 153002293 Common - hypothetical protein Shew185_3787 19 None None None 153000345 Common - Ppx/GppA phosphatase Shew185_1820 179 COG0248 GppA, Exopolyphosphatase Nucleotide transport and metabolism / Inorganic ion transport and metabolism 152998893 Common - phospholipid/glycerol acyltransferase Shew185_0341 77 COG0204 PlsC, 1-acyl-sn-glycerol-3-phosphate acyltransferase Lipid metabolism 153002158 Common - hypothetical protein Shew185_3651 3 None None None 153000203 Common - hypothetical protein Shew185_1676 11 COG4399 COG4399, Uncharacterized protein conserved in bacteria Function unknown 153002716 Common - ubiquinol oxidase, subunit II Shew185_4218 107 COG1622 CyoA, Heme/copper-type cytochrome/quinol oxidases, subunit 2 Energy production and conversion 152999670 Common - TonB-dependent receptor Shew185_1136 31 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 153002026 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Shew185_3517 224 COG0450 AhpC, Peroxiredoxin Posttranslational modification, protein turnover, chaperones 153002541 Common - DsrE family protein Shew185_4041 25 COG1553 DsrE, Uncharacterized conserved protein involved in intracellular sulfur reduction Inorganic ion transport and metabolism 152999404 Common - DEAD/DEAH box helicase domain protein Shew185_0868 231 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 152999047 Common - cell shape determining protein, MreB/Mrl family Shew185_0497 234 COG1077 MreB, Actin-like ATPase involved in cell morphogenesis Cell division and chromosome partitioning 153002327 Common - response regulator receiver protein Shew185_3821 133 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 152999185 Common - transcriptional regulator, LysR family Shew185_0642 179 COG0583 LysR, Transcriptional regulator Transcription 152999546 Common - protein of unknown function DUF924 Shew185_1012 63 COG3803 COG3803, Uncharacterized protein conserved in bacteria Function unknown 153001942 Common - NADH:ubiquinone oxidoreductase, subunit F Shew185_3433 156 COG2871 NqrF, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrF Energy production and conversion 152999051 Common - ribonuclease, Rne/Rng family Shew185_0501 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 153001184 Common - D,D-heptose 1,7-bisphosphate phosphatase Shew185_2667 131 COG0241 HisB, Histidinol phosphatase and related phosphatases Amino acid transport and metabolism 153000283 Common - protein of unknown function DUF480 Shew185_1758 41 COG3132 COG3132, Uncharacterized protein conserved in bacteria Function unknown 152999879 Common - OmpA/MotB domain protein Shew185_1347 143 COG1360 MotB, Flagellar motor protein Cell motility and secretion 153001401 Common - response regulator receiver modulated metal dependent phosphohydrolase Shew185_2885 122 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 152999610 Common - hypothetical protein Shew185_1076 6 None None None 153000307 Common - arsenate reductase Shew185_1782 117 COG1393 ArsC, Arsenate reductase and related proteins, glutaredoxin family Inorganic ion transport and metabolism 153000788 Common - phospholipase D/Transphosphatidylase Shew185_2268 28 COG1502 Cls, Phosphatidylserine/phosphatidylglycerophosphate/cardioli pin synthases and related enzymes Lipid metabolism 153000837 Common - conserved hypothetical methyl-accepting chemotaxis protein Shew185_2317 1 None None None 152999139 Common - Ig domain protein group 1 domain protein Shew185_0595 3 None None None 152998737 Common - NusG antitermination factor Shew185_0184 215 COG0250 NusG, Transcription antiterminator Transcription 153001825 Common - protein of unknown function DUF163 Shew185_3316 161 COG1576 COG1576, Uncharacterized conserved protein Function unknown 153000877 Common - gram negative topoisomerase IV, subunit B Shew185_2357 12 None None None 153001639 Common - recA protein Shew185_3126 224 COG0468 RecA, RecA/RadA recombinase DNA replication, recombination, and repair 153001476 Common - Protein-glutamate O-methyltransferase Shew185_2963 151 COG1352 CheR, Methylase of chemotaxis methyl-accepting proteins Cell motility and secretion / Signal transduction mechanisms 152999565 Common - Lysine exporter protein (LYSE/YGGA) Shew185_1031 108 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 153001505 Common - cytochrome d ubiquinol oxidase, subunit II Shew185_2992 156 COG1294 AppB, Cytochrome bd-type quinol oxidase, subunit 2 Energy production and conversion 153001259 Common - DSBA oxidoreductase Shew185_2743 7 COG2761 FrnE, Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis Secondary metabolites biosynthesis, transport, and catabolism 153001954 Common - hypothetical protein Shew185_3445 9 COG5373 COG5373, Predicted membrane protein Function unknown 153001949 Common - quorum-sensing autoinducer 2 (AI-2), LuxS Shew185_3440 55 COG1854 LuxS, LuxS protein involved in autoinducer AI2 synthesis Signal transduction mechanisms 152999946 Common - transcriptional regulator, XRE family Shew185_1414 16 COG1476 COG1476, Predicted transcriptional regulators Transcription 152999418 Common - phosphate transporter Shew185_0882 173 COG0306 PitA, Phosphate/sulphate permeases Inorganic ion transport and metabolism 153001281 Common - tRNA/rRNA methyltransferase (SpoU) Shew185_2765 20 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 152999872 Common - L-lactate permease Shew185_1340 103 COG1620 LldP, L-lactate permease Energy production and conversion 152999646 Common - OmpA/MotB domain protein Shew185_1112 156 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 153000480 Nonpathogen - hypothetical protein Shew185_1955 1 None None None 153002697 Common - bioH protein Shew185_4199 91 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 153000272 Common - type III restriction protein res subunit Shew185_1747 147 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 152999326 Common - L-sorbosone dehydrogenase, putative Shew185_0787 64 COG2133 COG2133, Glucose/sorbosone dehydrogenases Carbohydrate transport and metabolism 152999348 Common - protein of unknown function DUF558 Shew185_0809 205 COG1385 COG1385, Uncharacterized protein conserved in bacteria Function unknown 153002539 Common - hypothetical protein Shew185_4039 1 None None None 153001270 Common - hypothetical protein Shew185_2754 1 None None None 153001498 Common - hypothetical protein Shew185_2985 2 None None None 152998827 Common - hypothetical protein Shew185_0274 19 COG3296 COG3296, Uncharacterized protein conserved in bacteria Function unknown 153001440 Common - flagellar biosynthetic protein FliR Shew185_2924 128 COG1684 FliR, Flagellar biosynthesis pathway, component FliR Cell motility and secretion / Intracellular trafficking and secretion 152999084 Common - protein of unknown function DUF81 Shew185_0534 27 None None None 152999955 Common - beta-lactamase domain protein Shew185_1423 45 COG2015 COG2015, Alkyl sulfatase and related hydrolases Secondary metabolites biosynthesis, transport, and catabolism 153001117 Common - two component transcriptional regulator, LuxR family Shew185_2600 217 COG2197 CitB, Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain Signal transduction mechanisms / Transcription 153002263 Common - peptidase S9 prolyl oligopeptidase active site domain protein Shew185_3757 114 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 153001523 Common - 5'-Nucleotidase domain protein Shew185_3010 128 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 152999960 Common - hypothetical protein Shew185_1428 1 None None None 152999574 Common - hypothetical protein Shew185_1040 27 COG3610 COG3610, Uncharacterized conserved protein Function unknown 153001589 Common - hypothetical protein Shew185_3076 22 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 153002838 Common - Rhodanese domain protein Shew185_4342 128 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 153002534 Common - protein of unknown function DUF1107 Shew185_4034 3 None None None 153002480 Common - putative adenylate cyclase Shew185_3977 25 COG3072 CyaA, Adenylate cyclase Nucleotide transport and metabolism 152999428 Common - hypothetical protein Shew185_0892 4 None None None 152999856 Common - glucose-1-phosphate adenylyltransferase Shew185_1324 189 COG0448 GlgC, ADP-glucose pyrophosphorylase Carbohydrate transport and metabolism 153001336 Common - AlkA domain protein Shew185_2820 119 COG2169 Ada, Adenosine deaminase Nucleotide transport and metabolism 153002644 Common - hypothetical protein Shew185_4145 4 None None None 153001690 Common - diguanylate cyclase/phosphodiesterase Shew185_3178 164 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152999231 Common - ABC transporter related Shew185_0692 249 COG1127 Ttg2A, ABC-type transport system involved in resistance to organic solvents, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 152998963 Common - TatD-related deoxyribonuclease Shew185_0412 236 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 152999240 Common - AFG1-family ATPase Shew185_0701 103 COG1485 COG1485, Predicted ATPase General function prediction only 152999925 Common - FAD-dependent pyridine nucleotide-disulphide oxidoreductase Shew185_1393 239 COG0446 HcaD, Uncharacterized NAD(FAD)-dependent dehydrogenases General function prediction only 153000346 Common - Polyphosphate kinase Shew185_1821 161 COG0855 Ppk, Polyphosphate kinase Inorganic ion transport and metabolism 152998626 Common - TAP domain protein Shew185_0071 41 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152999155 Nonpathogen - hypothetical protein Shew185_0612 3 None None None 152998877 Common - Beta-ketoacyl synthase Shew185_0325 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153001329 Common - oxidoreductase domain protein Shew185_2813 37 COG0673 MviM, Predicted dehydrogenases and related proteins General function prediction only 152999214 Common - hypothetical protein Shew185_0674 9 None None None 153000958 Common - aminopeptidase N Shew185_2439 161 COG0308 PepN, Aminopeptidase N Amino acid transport and metabolism 153002425 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Shew185_3919 179 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 153002555 Common - porin Gram-negative type Shew185_4055 21 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 153002791 Common - malate synthase Shew185_4295 55 None None None 152998945 Common - cell division protein FtsL Shew185_0394 31 COG3116 FtsL, Cell division protein Cell division and chromosome partitioning 152999804 Common - aspartate kinase Shew185_1271 236 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 153001618 Common - hypothetical protein Shew185_3105 2 None None None 152998691 Nonpathogen - hypothetical protein Shew185_0138 2 None None None 152998688 Common - Oligopeptidase B Shew185_0135 100 COG1770 PtrB, Protease II Amino acid transport and metabolism 153001541 Common - MscS Mechanosensitive ion channel Shew185_3028 197 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 152999773 Common - anti sigma-E protein, RseA Shew185_1240 30 COG3073 RseA, Negative regulator of sigma E activity Signal transduction mechanisms 153000991 Common - protein of unknown function DUF489 Shew185_2472 41 COG2915 COG2915, Uncharacterized protein involved in purine metabolism General function prediction only 153001123 Common - ribosome modulation factor Shew185_2606 21 COG3130 Rmf, Ribosome modulation factor Translation, ribosomal structure and biogenesis 152998708 Common - general secretion pathway protein J Shew185_0155 27 COG4795 PulJ, Type II secretory pathway, component PulJ Intracellular trafficking and secretion 153000252 Common - peptidase M28 Shew185_1727 51 COG2234 Iap, Predicted aminopeptidases General function prediction only 153001160 Common - zinc carboxypeptidase-related protein Shew185_2643 17 COG3608 COG3608, Predicted deacylase General function prediction only 153001463 Common - flagellin domain protein Shew185_2950 119 COG1344 FlgL, Flagellin and related hook-associated proteins Cell motility and secretion 152999037 Common - type II secretion system protein E Shew185_0487 223 COG2804 PulE, Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB Cell motility and secretion / Intracellular trafficking and secretion 153001080 Common - putative phage repressor Shew185_2563 34 COG2932 COG2932, Predicted transcriptional regulator Transcription 153000435 Common - (NiFe) hydrogenase maturation protein HypF Shew185_1910 131 COG0068 HypF, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 152999952 Common - transcriptional regulator, putative Shew185_1420 28 None None None 152998808 Common - protein of unknown function Spy-related Shew185_0255 15 COG3678 CpxP, P pilus assembly/Cpx signaling pathway, periplasmic inhibitor/zinc-resistance associated protein Intracellular trafficking and secretion / Cell motility and secretio / Signal transduction mechanisms / Inorganic ion transport and metabolism 153000327 Common - Prolyl 4-hydroxylase alpha subunit Shew185_1802 29 COG3751 EGL-9, Predicted proline hydroxylase Posttranslational modification, protein turnover, chaperones 153002236 Common - hypothetical protein Shew185_3730 10 None None None 153000966 Common - nucleoside recognition domain protein Shew185_2447 39 COG2715 SpmA, Uncharacterized membrane protein, required for spore maturation in B.subtilis. General function prediction only 152999380 Common - pantoate--beta-alanine ligase Shew185_0844 182 COG0414 PanC, Panthothenate synthetase Coenzyme metabolism 153001167 Common - hypothetical protein Shew185_2650 6 COG2244 RfbX, Membrane protein involved in the export of O-antigen and teichoic acid General function prediction only 153000909 Common - RNA methyltransferase, TrmH family, group 1 Shew185_2389 166 COG0565 LasT, rRNA methylase Translation, ribosomal structure and biogenesis 153001895 Common - hypothetical protein Shew185_3386 2 None None None 152999107 Common - phage integrase family protein Shew185_0557 18 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 153000765 Common - methyl-accepting chemotaxis sensory transducer Shew185_2245 153 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153002721 Common - alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen Shew185_4223 49 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 153000082 Common - Integral membrane protein TerC Shew185_1553 95 COG0861 TerC, Membrane protein TerC, possibly involved in tellurium resistance Inorganic ion transport and metabolism 153002281 Common - ribosome small subunit-dependent GTPase A Shew185_3775 163 COG1162 COG1162, Predicted GTPases General function prediction only 152999100 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Shew185_0550 90 COG0546 Gph, Predicted phosphatases General function prediction only 152999740 Common - hypothetical protein Shew185_1207 18 None None None 153002147 Common - 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase Shew185_3640 141 COG0620 MetE, Methionine synthase II (cobalamin-independent) Amino acid transport and metabolism 153000030 Common - putative transcriptional regulator, MerR family Shew185_1498 143 COG0789 SoxR, Predicted transcriptional regulators Transcription 153001382 Common - Electron transfer flavoprotein alpha/beta-subunit Shew185_2866 153 COG2086 FixA, Electron transfer flavoprotein, beta subunit Energy production and conversion 153002093 Common - transposase Shew185_3586 9 None None None 153001995 Common - glutamine amidotransferase class-I Shew185_3486 87 COG0518 GuaA, GMP synthase - Glutamine amidotransferase domain Nucleotide transport and metabolism 152999208 Common - Lysine exporter protein (LYSE/YGGA) Shew185_0668 87 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 153001071 Common - transcriptional regulator, XRE family Shew185_2554 2 COG1396 HipB, Predicted transcriptional regulators Transcription 152999997 Common - protein of unknown function DUF885 Shew185_1465 44 COG4805 COG4805, Uncharacterized protein conserved in bacteria Function unknown 153001748 Common - CRISPR-associated protein, Csy1 family Shew185_3239 18 None None None 152999023 Common - Sporulation domain protein Shew185_0473 35 COG3087 FtsN, Cell division protein Cell division and chromosome partitioning 153000552 Common - binding-protein-dependent transport systems inner membrane component Shew185_2027 196 COG4176 ProW, ABC-type proline/glycine betaine transport system, permease component Amino acid transport and metabolism 152999513 Common - cobalamin 5'-phosphate synthase Shew185_0978 94 COG0368 CobS, Cobalamin-5-phosphate synthase Coenzyme metabolism 153001312 Common - hypothetical protein Shew185_2796 40 None None None 153000576 Common - diguanylate phosphodiesterase Shew185_2052 156 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 152999395 Common - short-chain dehydrogenase/reductase SDR Shew185_0859 235 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153000749 Common - hypothetical protein Shew185_2228 13 None None None 153001032 Common - citrate synthase I Shew185_2513 194 COG0372 GltA, Citrate synthase Energy production and conversion 153001886 Common - hypothetical protein Shew185_3377 1 None None None 153002615 Common - Sel1 domain protein repeat-containing protein Shew185_4116 20 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 152998765 Common - ribosomal protein L18 Shew185_0212 211 COG0256 RplR, Ribosomal protein L18 Translation, ribosomal structure and biogenesis 153000744 Nonpathogen - hypothetical protein Shew185_2223 1 None None None 153001659 Common - multi-sensor hybrid histidine kinase Shew185_3146 226 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153001026 Common - 2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase Shew185_2507 195 COG0508 AceF, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes Energy production and conversion 153000684 Common - PP-loop domain protein Shew185_2160 163 COG0037 MesJ, Predicted ATPase of the PP-loop superfamily implicated in cell cycle control Cell division and chromosome partitioning 153000182 Common - hypothetical protein Shew185_1655 1 None None None 152999723 Common - GatB/Yqey domain protein Shew185_1190 153 COG1610 COG1610, Uncharacterized conserved protein Function unknown 153001703 Common - putative signal transduction protein Shew185_3191 46 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 153001203 Common - O-methyltransferase family 2 Shew185_2686 22 None None None 152999439 Common - protein of unknown function DUF112 transmembrane Shew185_0903 77 COG3333 COG3333, Uncharacterized protein conserved in bacteria Function unknown 152999568 Common - uracil-DNA glycosylase Shew185_1034 129 COG0692 Ung, Uracil DNA glycosylase DNA replication, recombination, and repair 152998855 Nonpathogen - hypothetical protein Shew185_0303 1 None None None 152998910 Common - hypothetical protein Shew185_0358 6 None None None 152999264 Nonpathogen - hypothetical protein Shew185_0725 1 None None None 153002405 Common - protein of unknown function DUF853 NPT hydrolase putative Shew185_3899 77 COG0433 COG0433, Predicted ATPase General function prediction only 152999895 Common - porin Gram-negative type Shew185_1363 46 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 153001101 Common - Nucleoside-triphosphate--adenylate kinase Shew185_2584 229 COG0563 Adk, Adenylate kinase and related kinases Nucleotide transport and metabolism 152998635 Common - thioesterase superfamily protein Shew185_0080 70 COG0824 FcbC, Predicted thioesterase General function prediction only 153000491 Common - hypothetical protein Shew185_1966 8 None None None 152999315 Common - phage shock protein C, PspC Shew185_0776 1 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 152998747 Common - translation elongation factor Tu Shew185_0194 249 COG0050 TufB, GTPases - translation elongation factors Translation, ribosomal structure and biogenesis 153000533 Common - AsmA family protein Shew185_2008 63 COG2982 AsmA, Uncharacterized protein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 153002866 Common - ATP synthase F0, C subunit Shew185_4370 74 COG0636 AtpE, F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K Energy production and conversion 153001582 Common - putative transcriptional regulator, MerR family Shew185_3069 30 COG0789 SoxR, Predicted transcriptional regulators Transcription 153002123 Common - outer membrane lipoprotein LolB Shew185_3616 44 COG3017 LolB, Outer membrane lipoprotein involved in outer membrane biogenesis Cell envelope biogenesis, outer membrane 152999506 Nonpathogen - hypothetical protein Shew185_0971 1 None None None 153000360 Common - protein of unknown function DUF413 Shew185_1835 23 COG3085 COG3085, Uncharacterized protein conserved in bacteria Function unknown 152999149 Common - PEBP family protein Shew185_0606 63 COG1881 COG1881, Phospholipid-binding protein General function prediction only 153000010 Common - UTP-glucose-1-phosphate uridylyltransferase Shew185_1478 229 COG1210 GalU, UDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 152999479 Common - 6,7-dihydropteridine reductase Shew185_0943 81 COG0778 NfnB, Nitroreductase Energy production and conversion 153002191 Common - putative thiol-disulphide oxidoreductase DCC Shew185_3684 21 COG3011 COG3011, Uncharacterized protein conserved in bacteria Function unknown 152999641 Common - hypothetical protein Shew185_1107 1 None None None 152999364 Common - prepilin-type cleavage/methylation-like protein Shew185_0828 1 COG4967 PilV, Tfp pilus assembly protein PilV Cell motility and secretion / Intracellular trafficking and secretion 153001556 Common - protein of unknown function DUF167 Shew185_3043 83 COG1872 COG1872, Uncharacterized conserved protein Function unknown 153002564 Common - transcriptional regulator, TetR family Shew185_4064 6 COG1309 AcrR, Transcriptional regulator Transcription 153002268 Common - Cytochrome b/b6 domain Shew185_3762 149 COG1290 QcrB, Cytochrome b subunit of the bc complex Energy production and conversion 152999554 Common - TonB family protein Shew185_1020 32 COG0810 TonB, Periplasmic protein TonB, links inner and outer membranes Cell envelope biogenesis, outer membrane 152999016 Common - protein of unknown function DUF465 Shew185_0466 28 COG2841 COG2841, Uncharacterized protein conserved in bacteria Function unknown 153000296 Common - Fatty acid metabolism transcriptional regulator FadR Shew185_1771 69 COG2186 FadR, Transcriptional regulators Transcription 153000659 Common - metal dependent phosphohydrolase Shew185_2135 25 COG1896 COG1896, Predicted hydrolases of HD superfamily General function prediction only 153001018 Common - hypothetical protein Shew185_2499 1 None None None 153002127 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Shew185_3620 173 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 153002438 Common - 2-oxo-acid dehydrogenase E1 subunit, homodimeric type Shew185_3934 154 COG2609 AceE, Pyruvate dehydrogenase complex, dehydrogenase (E1) component Energy production and conversion 153000009 Common - UDP-glucose 4-epimerase Shew185_1477 232 COG1087 GalE, UDP-glucose 4-epimerase Cell envelope biogenesis, outer membrane 152998862 Common - diguanylate cyclase Shew185_0310 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153001279 Common - Beta-ketoacyl synthase Shew185_2763 209 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153002021 Common - hypothetical protein Shew185_3512 43 COG0668 MscS, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 153002489 Common - OmpA/MotB domain protein Shew185_3986 156 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 153000017 Common - OmpW family protein Shew185_1485 71 COG3047 OmpW, Outer membrane protein W Cell envelope biogenesis, outer membrane 152999421 Common - Ion transport 2 domain protein Shew185_0885 51 None None None 153002494 Common - protein of unknown function DUF526 Shew185_3991 52 COG2960 COG2960, Uncharacterized protein conserved in bacteria Function unknown 153001133 Common - adenine phosphoribosyltransferase Shew185_2616 186 COG0503 Apt, Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins Nucleotide transport and metabolism 152998935 Common - response regulator receiver protein Shew185_0384 4 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 153002355 Common - outer membrane efflux protein Shew185_3849 13 COG1538 TolC, Outer membrane protein Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion 153002091 Common - putative transcriptional regulator, AsnC family Shew185_3584 155 COG1522 Lrp, Transcriptional regulators Transcription 152999187 Common - chaperonin Cpn10 Shew185_0644 214 COG0234 GroS, Co-chaperonin GroES (HSP10) Posttranslational modification, protein turnover, chaperones 153000995 Common - Glu/Leu/Phe/Val dehydrogenase dimerisation region Shew185_2476 173 COG0334 GdhA, Glutamate dehydrogenase/leucine dehydrogenase Amino acid transport and metabolism 153000047 Common - acetyl-CoA hydrolase/transferase Shew185_1517 102 COG0427 ACH1, Acetyl-CoA hydrolase Energy production and conversion 153001980 Common - hypothetical protein Shew185_3471 4 None None None 152999748 Common - hypothetical protein Shew185_1215 2 None None None 153002760 Common - hypothetical protein Shew185_4262 10 None None None 153001526 Common - Pirin domain protein Shew185_3013 141 COG1741 COG1741, Pirin-related protein General function prediction only 153001555 Common - protein of unknown function YGGT Shew185_3042 66 COG0762 COG0762, Predicted integral membrane protein Function unknown 152999257 Common - transposase IS200-family protein Shew185_0718 73 COG1943 COG1943, Transposase and inactivated derivatives DNA replication, recombination, and repair 152999628 Nonpathogen - hypothetical protein Shew185_1094 1 None None None 153001115 Common - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Shew185_2598 205 COG0558 PgsA, Phosphatidylglycerophosphate synthase Lipid metabolism 153000461 Common - periplasmic nitrate reductase, large subunit Shew185_1936 186 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 153002192 Common - malate dehydrogenase, NAD-dependent Shew185_3685 187 COG0039 Mdh, Malate/lactate dehydrogenases Energy production and conversion 153002387 Common - hypothetical protein Shew185_3881 6 None None None 153002279 Common - hypothetical protein Shew185_3773 6 None None None 153002407 Common - TRAP transporter solute receptor, TAXI family Shew185_3901 90 COG2358 Imp, TRAP-type uncharacterized transport system, periplasmic component General function prediction only 152999489 Common - LrgA family protein Shew185_0954 23 COG1380 COG1380, Putative effector of murein hydrolase LrgA General function prediction only 153002178 Common - hypothetical protein Shew185_3671 30 None None None 153001753 Common - response regulator receiver protein Shew185_3244 11 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153001066 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Shew185_2548 171 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153002441 Common - N-acetylmuramoyl-L-alanine amidase family 2 Shew185_3937 106 COG3023 AmpD, Negative regulator of beta-lactamase expression Defense mechanisms 153000025 Common - Enoyl-CoA hydratase/isomerase Shew185_1493 132 COG1024 CaiD, Enoyl-CoA hydratase/carnithine racemase Lipid metabolism 152998570 Common - acetyl-CoA C-acyltransferase FadA Shew185_0015 187 COG0183 PaaJ, Acetyl-CoA acetyltransferase Lipid metabolism 152998603 Common - putative transcriptional regulator Shew185_0048 40 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 153001356 Common - DoxX family protein Shew185_2840 2 None None None 153002010 Common - hypothetical protein Shew185_3501 1 None None None 152999449 Common - hypothetical protein Shew185_0913 1 None None None 153001549 Common - Ferrochelatase Shew185_3036 158 COG0276 HemH, Protoheme ferro-lyase (ferrochelatase) Coenzyme metabolism 153000713 Common - transcriptional factor MdcH Shew185_2191 29 COG2378 COG2378, Predicted transcriptional regulator Transcription 153002633 Common - Methyltransferase type 12 Shew185_4134 24 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 153000220 Common - transposase Shew185_1694 32 None None None 153001837 Common - protein of unknown function DUF1624 Shew185_3328 24 COG3503 COG3503, Predicted membrane protein Function unknown 153000020 Common - Homoserine O-succinyltransferase Shew185_1488 64 COG1897 MetA, Homoserine trans-succinylase Amino acid transport and metabolism 153002400 Common - hypothetical protein Shew185_3894 32 None None None 153002603 Common - cytoplasmic chaperone TorD family protein Shew185_4104 33 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 153001486 Common - NAD-dependent epimerase/dehydratase Shew185_2973 237 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 152999350 Common - protein of unknown function DUF335 SprT Shew185_0811 26 COG3091 SprT, Uncharacterized protein conserved in bacteria Function unknown 152999815 Common - sigma 54 modulation protein/ribosomal protein S30EA Shew185_1283 33 COG1544 COG1544, Ribosome-associated protein Y (PSrp-1) Translation, ribosomal structure and biogenesis 152999462 Common - Phospholipase A(1) Shew185_0926 52 COG2829 PldA, Outer membrane phospholipase A Cell envelope biogenesis, outer membrane 153002681 Common - cytochrome c oxidase subunit III Shew185_4183 153 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 153002009 Common - hypothetical protein Shew185_3500 10 COG0785 CcdA, Cytochrome c biogenesis protein Posttranslational modification, protein turnover, chaperones 153001708 Common - peptidase U32 Shew185_3196 139 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 152998863 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Shew185_0311 46 COG0348 NapH, Polyferredoxin Energy production and conversion 153001941 Common - ApbE family lipoprotein Shew185_3432 139 COG1477 ApbE, Membrane-associated lipoprotein involved in thiamine biosynthesis Coenzyme metabolism 153000563 Common - alpha amylase catalytic region Shew185_2039 162 COG0366 AmyA, Glycosidases Carbohydrate transport and metabolism 153001540 Common - OmpA/MotB domain protein Shew185_3027 137 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 153002416 Common - band 7 protein Shew185_3910 126 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 153002214 Common - ammonium transporter Shew185_3707 202 COG0004 AmtB, Ammonia permease Inorganic ion transport and metabolism 152999087 Common - aspartate kinase Shew185_0537 235 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 153000650 Common - transcriptional regulator, TetR family Shew185_2126 85 COG1309 AcrR, Transcriptional regulator Transcription 152999754 Common - glutamate synthase, small subunit Shew185_1221 209 COG0493 GltD, NADPH-dependent glutamate synthase beta chain and related oxidoreductases Amino acid transport and metabolism / General function prediction only 153001884 Nonpathogen - hypothetical protein Shew185_3375 2 None None None 153000752 Nonpathogen - hypothetical protein Shew185_2231 1 None None None 153000696 Common - response regulator receiver modulated metal dependent phosphohydrolase Shew185_2172 123 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 153002035 Common - methyltransferase small Shew185_3526 69 COG4123 COG4123, Predicted O-methyltransferase General function prediction only 153000002 Common - ROK family protein Shew185_1470 129 COG1940 NagC, Transcriptional regulator/sugar kinase Transcription / Carbohydrate transport and metabolism 153002462 Common - succinate dehydrogenase and fumarate reductase iron-sulfur protein Shew185_3959 206 COG0479 FrdB, Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit Energy production and conversion 152999621 Common - protein of unknown function DUF152 Shew185_1087 180 COG1496 COG1496, Uncharacterized conserved protein Function unknown 153000519 Common - hypothetical protein Shew185_1994 12 None None None 153002469 Common - UvrD/REP helicase Shew185_3966 217 COG0210 UvrD, Superfamily I DNA and RNA helicases DNA replication, recombination, and repair 153000029 Common - peptidase S9 prolyl oligopeptidase active site domain protein Shew185_1497 118 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 153000386 Common - phage integrase family protein Shew185_1861 32 COG0582 XerC, Integrase DNA replication, recombination, and repair 152999314 Common - hypothetical protein Shew185_0775 1 None None None 153002246 Common - hypothetical protein Shew185_3740 3 COG4711 COG4711, Predicted membrane protein Function unknown 153002150 Common - hypothetical protein Shew185_3643 3 None None None 152999357 Common - transcriptional regulator, LysR family Shew185_0821 187 COG0583 LysR, Transcriptional regulator Transcription 153001592 Common - putative endoribonuclease L-PSP Shew185_3079 178 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 153001655 Common - Domain of unknown function DUF1852 Shew185_3142 24 None None None 152998950 Common - UDP-N-acetylmuramoylalanine--D-glutamate ligase Shew185_0399 208 COG0771 MurD, UDP-N-acetylmuramoylalanine-D-glutamate ligase Cell envelope biogenesis, outer membrane 152999167 Common - putative transmembrane protein Shew185_0624 72 COG3000 ERG3, Sterol desaturase Lipid metabolism 153001760 Common - hypothetical protein Shew185_3251 2 None None None 153002661 Common - cell division ATP-binding protein FtsE Shew185_4163 249 COG2884 FtsE, Predicted ATPase involved in cell division Cell division and chromosome partitioning 153001724 Common - cytoplasmic chaperone TorD family protein Shew185_3214 26 COG3381 TorD, Uncharacterized component of anaerobic dehydrogenases General function prediction only 152998834 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Shew185_0281 138 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 153002087 Common - hypothetical protein Shew185_3580 22 COG2849 COG2849, Uncharacterized protein conserved in bacteria Function unknown 153002625 Common - RNA methyltransferase, TrmH family, group 2 Shew185_4126 160 COG0219 CspR, Predicted rRNA methylase (SpoU class) Translation, ribosomal structure and biogenesis 153000706 Common - putative esterase Shew185_2182 43 COG2819 COG2819, Predicted hydrolase of the alpha/beta superfamily General function prediction only 152999735 Common - Citrate transporter Shew185_1202 52 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 152999634 Common - hypothetical protein Shew185_1100 38 COG4764 COG4764, Uncharacterized protein conserved in bacteria Function unknown 153001161 Common - conserved hypothetical ABC transporter protein Shew185_2644 11 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 152999678 Common - ATPase BadF/BadG/BcrA/BcrD type Shew185_1144 61 COG2971 COG2971, Predicted N-acetylglucosamine kinase Carbohydrate transport and metabolism 153001224 Common - ABC transporter related Shew185_2708 249 COG4181 COG4181, Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component Secondary metabolites biosynthesis, transport, and catabolism 153000943 Common - imidazoleglycerol phosphate synthase, cyclase subunit Shew185_2424 215 COG0107 HisF, Imidazoleglycerol-phosphate synthase Amino acid transport and metabolism 153002063 Common - protein of unknown function DUF84 Shew185_3554 33 COG1986 COG1986, Uncharacterized conserved protein Function unknown 152998810 Common - hypothetical protein Shew185_0257 1 None None None 153000757 Common - ABC transporter related Shew185_2237 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 153001985 Common - peptide deformylase Shew185_3476 203 COG0242 Def, N-formylmethionyl-tRNA deformylase Translation, ribosomal structure and biogenesis 153000371 Nonpathogen - hypothetical protein Shew185_1846 1 None None None 153001389 Common - prolyl-tRNA synthetase Shew185_2873 247 COG0442 ProS, Prolyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152998565 Common - DNA-3-methyladenine glycosylase I Shew185_0010 132 COG2818 Tag, 3-methyladenine DNA glycosylase DNA replication, recombination, and repair 152999538 Common - curli production assembly/transport component CsgF, putative Shew185_1004 13 None None None 153002227 Common - Inositol phosphatase/fructose-16-bisphosphatase Shew185_3721 108 COG0158 Fbp, Fructose-1,6-bisphosphatase Carbohydrate transport and metabolism 152999386 Common - sugar fermentation stimulation protein Shew185_0850 108 COG1489 SfsA, DNA-binding protein, stimulates sugar fermentation General function prediction only 153000173 Common - Patatin Shew185_1646 129 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 153001427 Common - putative CheW protein Shew185_2911 135 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153001914 Common - GCN5-related N-acetyltransferase Shew185_3405 91 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 153002195 Common - transcriptional regulator, LysR family Shew185_3688 124 COG0583 LysR, Transcriptional regulator Transcription 152998930 Common - amino-acid N-acetyltransferase Shew185_0379 207 COG0548 ArgB, Acetylglutamate kinase Amino acid transport and metabolism 153001533 Common - transcriptional regulator, CopG family Shew185_3020 1 None None None 153001936 Common - DNA-directed DNA polymerase Shew185_3427 184 COG0389 DinP, Nucleotidyltransferase/DNA polymerase involved in DNA repair DNA replication, recombination, and repair 152999440 Common - signal transduction histidine kinase regulating citrate/malate metabolism Shew185_0904 139 COG3290 CitA, Signal transduction histidine kinase regulating citrate/malate metabolism Signal transduction mechanisms 153001170 Common - homogentisate 12-dioxygenase Shew185_2653 51 COG3508 HmgA, Homogentisate 1,2-dioxygenase Secondary metabolites biosynthesis, transport, and catabolism 153000636 Common - DNA adenine methylase Shew185_2112 105 COG0338 Dam, Site-specific DNA methylase DNA replication, recombination, and repair 153001008 Common - DNA topoisomerase I Shew185_2489 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 152999902 Common - GCN5-related N-acetyltransferase Shew185_1370 2 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 153002792 Common - conserved hypothetical protein 698 Shew185_4296 115 COG2855 COG2855, Predicted membrane protein Function unknown 152999160 Common - anaerobic c4-dicarboxylate antiporter, Dcu family Shew185_0617 36 COG2704 DcuB, Anaerobic C4-dicarboxylate transporter General function prediction only 153002359 Common - Class I peptide chain release factor Shew185_3853 115 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 153001495 Common - Nucleotidyl transferase Shew185_2982 216 COG1208 GCD1, Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) Cell envelope biogenesis, outer membrane / Translation, ribosomal structure and biogenesis 153002118 Common - Invasion gene expression up-regulator SirB Shew185_3611 39 COG3094 COG3094, Uncharacterized protein conserved in bacteria Function unknown 153000820 Common - peptidase M14 carboxypeptidase A Shew185_2300 31 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 152999480 Common - GCN5-related N-acetyltransferase Shew185_0944 108 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 153001812 Common - tRNA-i(6)A37 thiotransferase enzyme MiaB Shew185_3303 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 153001177 Common - dipeptidase, putative Shew185_2660 36 COG0624 ArgE, Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases Amino acid transport and metabolism 152998817 Common - transcriptional regulator, TetR family Shew185_0264 70 COG1309 AcrR, Transcriptional regulator Transcription 153000543 Common - Acetamidase/Formamidase Shew185_2018 53 COG2421 COG2421, Predicted acetamidase/formamidase Energy production and conversion 153001841 Common - major facilitator superfamily MFS_1 Shew185_3332 5 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 153000239 Common - 3-oxoacyl-(acyl-carrier-protein) synthase III Shew185_1714 226 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 152999760 Common - DNA mismatch repair endonuclease mutH Shew185_1227 28 COG3066 MutH, DNA mismatch repair protein DNA replication, recombination, and repair 153001391 Common - 3-methyl-2-oxobutanoate hydroxymethyltransferase Shew185_2875 195 COG0413 PanB, Ketopantoate hydroxymethyltransferase Coenzyme metabolism 153001006 Common - transcriptional regulator, LysR family Shew185_2487 187 COG0583 LysR, Transcriptional regulator Transcription 153001928 Common - alpha/beta hydrolase fold Shew185_3419 9 COG2267 PldB, Lysophospholipase Lipid metabolism 153002643 Common - hypothetical protein Shew185_4144 3 None None None 153000227 Common - hypothetical protein Shew185_1702 15 None None None 152998916 Common - hypothetical protein Shew185_0364 11 None None None 152999862 Common - hypothetical protein Shew185_1330 8 None None None 153001578 Common - amine oxidase Shew185_3065 70 COG2907 COG2907, Predicted NAD/FAD-binding protein General function prediction only 153002511 Common - amino acid-binding ACT domain protein Shew185_4008 22 COG3978 COG3978, Acetolactate synthase (isozyme II), small (regulatory) subunit Function unknown 152999108 Common - phage integrase family protein Shew185_0558 16 None None None 153000196 Common - tetraacyldisaccharide 4'-kinase Shew185_1669 130 COG1663 LpxK, Tetraacyldisaccharide-1-P 4'-kinase Cell envelope biogenesis, outer membrane 153002718 Common - Cytochrome o ubiquinol oxidase subunit III Shew185_4220 159 COG1845 CyoC, Heme/copper-type cytochrome/quinol oxidase, subunit 3 Energy production and conversion 153000849 Common - alpha-glucosidase Shew185_2329 18 None None None 153002111 Common - nitrogen regulatory protein P-II Shew185_3604 187 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 153000232 Common - ribonuclease, Rne/Rng family Shew185_1707 185 COG1530 CafA, Ribonucleases G and E Translation, ribosomal structure and biogenesis 153001360 Common - AMP-dependent synthetase and ligase Shew185_2844 214 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 153001158 Common - protein of unknown function DUF307 Shew185_2641 43 COG3304 COG3304, Predicted membrane protein Function unknown 153001010 Common - Ig domain protein group 1 domain protein Shew185_2491 78 None None None 153001644 Common - stationary-phase survival protein SurE Shew185_3131 186 COG0496 SurE, Predicted acid phosphatase General function prediction only 152998617 Common - major facilitator superfamily MFS_1 Shew185_0062 115 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 152998684 Common - molybdenum cofactor synthesis domain Shew185_0131 195 COG0303 MoeA, Molybdopterin biosynthesis enzyme Coenzyme metabolism 152998721 Common - 3'(2'),5'-bisphosphate nucleotidase Shew185_0168 197 COG1218 CysQ, 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase Inorganic ion transport and metabolism 153001568 Common - YceI family protein Shew185_3055 113 COG2353 COG2353, Uncharacterized conserved protein Function unknown 153000425 Common - phenylalanyl-tRNA synthetase, alpha subunit Shew185_1900 249 COG0016 PheS, Phenylalanyl-tRNA synthetase alpha subunit Translation, ribosomal structure and biogenesis 153000575 Common - ATPase associated with various cellular activities AAA_3 Shew185_2051 179 COG0714 COG0714, MoxR-like ATPases General function prediction only 152999976 Common - methionine aminopeptidase, type I Shew185_1444 248 COG0024 Map, Methionine aminopeptidase Translation, ribosomal structure and biogenesis 153000451 Common - hypothetical protein Shew185_1926 1 None None None 152998771 Common - ribosomal protein S13 Shew185_0218 220 COG0099 RpsM, Ribosomal protein S13 Translation, ribosomal structure and biogenesis 153000813 Common - NADH:flavin oxidoreductase/NADH oxidase Shew185_2293 200 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 152998592 Common - carbonic anhydrase, family 3 Shew185_0037 188 COG0663 PaaY, Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily General function prediction only 152998900 Common - Na+/Ca+ antiporter, CaCA family Shew185_0348 120 COG0530 ECM27, Ca2+/Na+ antiporter Inorganic ion transport and metabolism 153001777 Nonpathogen - hypothetical protein Shew185_3268 1 None None None 153001264 Common - hypothetical protein Shew185_2748 15 COG2068 COG2068, Uncharacterized MobA-related protein General function prediction only 153001291 Common - hypothetical protein Shew185_2775 2 None None None 153001948 Common - TonB-dependent receptor Shew185_3439 12 COG4772 FecA, Outer membrane receptor for Fe3+-dicitrate Inorganic ion transport and metabolism 152998908 Common - aminoglycoside phosphotransferase Shew185_0356 19 COG2334 COG2334, Putative homoserine kinase type II (protein kinase fold) General function prediction only 152999453 Common - NAD(P)(+) transhydrogenase (AB-specific) Shew185_0917 123 COG1282 PntB, NAD/NADP transhydrogenase beta subunit Energy production and conversion 153000250 Common - Patatin Shew185_1725 30 COG4667 COG4667, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 153001970 Common - pseudouridine synthase Shew185_3461 204 COG1187 RsuA, 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases Translation, ribosomal structure and biogenesis 153000158 Common - diguanylate cyclase Shew185_1631 3 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152998774 Common - DNA-directed RNA polymerase, alpha subunit Shew185_0221 216 COG0202 RpoA, DNA-directed RNA polymerase, alpha subunit/40 kD subunit Transcription 153000281 Common - ABC transporter related Shew185_1756 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 153000161 Common - GCN5-related N-acetyltransferase Shew185_1634 138 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 153002754 Common - Oligopeptidase A Shew185_4256 123 COG0339 Dcp, Zn-dependent oligopeptidases Amino acid transport and metabolism 153001517 Common - histidyl-tRNA synthetase Shew185_3004 249 COG0124 HisS, Histidyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153001153 Common - RNA polymerase, sigma-24 subunit, ECF subfamily Shew185_2636 133 COG1595 RpoE, DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog Transcription 152998889 Common - aconitate hydratase Shew185_0337 60 COG0365 Acs, Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases Lipid metabolism 152999935 Common - hypothetical protein Shew185_1403 2 None None None 153001301 Common - von Willebrand factor type A Shew185_2785 74 COG2304 COG2304, Uncharacterized protein containing a von Willebrand factor type A (vWA) domain General function prediction only 153002801 Nonpathogen - hypothetical protein Shew185_4305 1 None None None 153000202 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Shew185_1675 41 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 153001098 Common - NAD+ synthetase Shew185_2581 133 COG0171 NadE, NAD synthase Coenzyme metabolism 153000506 Common - hypothetical protein Shew185_1981 27 COG4268 McrC, McrBC 5-methylcytosine restriction system component Defense mechanisms 152999573 Common - protein of unknown function DUF1212 Shew185_1039 50 COG2966 COG2966, Uncharacterized conserved protein Function unknown 153000131 Common - binding-protein-dependent transport systems inner membrane component Shew185_1602 214 COG4171 SapC, ABC-type antimicrobial peptide transport system, permease component Defense mechanisms 153000869 Common - Phosphotransferase system, phosphocarrier protein HPr Shew185_2349 110 COG1925 FruB, Phosphotransferase system, HPr-related proteins Carbohydrate transport and metabolism 153001188 Common - Exonuclease RNase T and DNA polymerase III Shew185_2671 62 COG2176 PolC, DNA polymerase III, alpha subunit (gram-positive type) DNA replication, recombination, and repair 153001326 Common - protein of unknown function DUF479 Shew185_2810 30 COG3124 COG3124, Uncharacterized protein conserved in bacteria Function unknown 153000458 Common - ATP-dependent helicase HrpA Shew185_1933 134 COG1643 HrpA, HrpA-like helicases DNA replication, recombination, and repair 152999323 Common - Calcineurin phosphoesterase domain protein Shew185_0784 76 COG1409 Icc, Predicted phosphohydrolases General function prediction only 153002366 Common - oxidoreductase FAD/NAD(P)-binding domain protein Shew185_3860 88 COG0543 UbiB, 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases Coenzyme metabolism / Energy production and conversion 153002836 Common - 2-amino-3-ketobutyrate coenzyme A ligase Shew185_4340 193 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 152998578 Common - potassium uptake protein, TrkH family Shew185_0023 139 COG0168 TrkG, Trk-type K+ transport systems, membrane components Inorganic ion transport and metabolism 153001337 Common - ABC transporter related Shew185_2821 249 COG1132 MdlB, ABC-type multidrug transport system, ATPase and permease components Defense mechanisms 152998778 Common - Heme exporter protein D (CcmD) Shew185_0225 22 COG3114 CcmD, Heme exporter protein D Intracellular trafficking and secretion 153000091 Common - transcriptional regulator, AraC family Shew185_1562 110 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 153000982 Common - Arginyltransferase Shew185_2463 85 COG2935 COG2935, Putative arginyl-tRNA:protein arginylyltransferase Posttranslational modification, protein turnover, chaperones 152998668 Common - protein of unknown function DUF1090 Shew185_0115 17 None None None 153000183 Common - hypothetical protein Shew185_1656 37 COG4628 COG4628, Uncharacterized conserved protein Function unknown 152999822 Common - methyl-accepting chemotaxis sensory transducer Shew185_1290 148 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153000721 Common - protein of unknown function DUF81 Shew185_2199 15 COG0730 COG0730, Predicted permeases General function prediction only 152998993 Common - transposase IS4 family protein Shew185_0443 33 COG5433 COG5433, Transposase DNA replication, recombination, and repair 152999205 Common - Alkaline phosphatase Shew185_0665 86 COG1785 PhoA, Alkaline phosphatase Inorganic ion transport and metabolism 153000214 Common - hypothetical protein Shew185_1688 4 None None None 153001313 Common - Rhodanese domain protein Shew185_2797 119 COG0607 PspE, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 153000167 Common - SMC domain protein Shew185_1640 100 COG0419 SbcC, ATPase involved in DNA repair DNA replication, recombination, and repair 153001862 Common - GCN5-related N-acetyltransferase Shew185_3353 18 COG0456 RimI, Acetyltransferases General function prediction only 153002142 Common - hypothetical protein Shew185_3635 1 None None None 153001300 Common - hypothetical protein Shew185_2784 4 COG0598 CorA, Mg2+ and Co2+ transporters Inorganic ion transport and metabolism 153002527 Common - isocitrate lyase family protein Shew185_4025 135 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 153000065 Common - phosphate ABC transporter, ATPase subunit Shew185_1535 249 COG1117 PstB, ABC-type phosphate transport system, ATPase component Inorganic ion transport and metabolism 153000881 Common - Glutamine--scyllo-inositol transaminase Shew185_2361 195 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 153000527 Common - cyanophycinase-related exopeptidase-like protein Shew185_2002 20 COG4242 CphB, Cyanophycinase and related exopeptidases Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism 153002749 Common - efflux transporter, RND family, MFP subunit Shew185_4251 152 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 152998792 Common - two component transcriptional regulator, winged helix family Shew185_0239 218 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153000558 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Shew185_2034 47 COG0346 GloA, Lactoylglutathione lyase and related lyases Amino acid transport and metabolism 153000923 Common - protein of unknown function UPF0227 Shew185_2404 20 COG3150 COG3150, Predicted esterase General function prediction only 153000104 Common - hypothetical protein Shew185_1575 1 COG5232 SEC62, Preprotein translocase subunit Sec62 Intracellular trafficking and secretion 153001236 Common - Sua5/YciO/YrdC/YwlC family protein Shew185_2720 177 COG0009 SUA5, Putative translation factor (SUA5) Translation, ribosomal structure and biogenesis 152999501 Common - Gluconate 2-dehydrogenase (acceptor) Shew185_0966 61 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 152999706 Common - 4-aminobutyrate aminotransferase Shew185_1172 237 COG0160 GabT, 4-aminobutyrate aminotransferase and related aminotransferases Amino acid transport and metabolism 153001439 Common - flagellar biosynthetic protein FlhB Shew185_2923 130 COG1377 FlhB, Flagellar biosynthesis pathway, component FlhB Cell motility and secretion / Intracellular trafficking and secretion 153000434 Common - hypothetical protein Shew185_1909 4 None None None 153002723 Common - cytochrome c biogenesis protein transmembrane region Shew185_4225 132 COG4232 COG4232, Thiol:disulfide interchange protein Posttranslational modification, protein turnover, chaperones / Energy production and conversion 153001219 Common - dihydroneopterin aldolase Shew185_2703 48 COG1539 FolB, Dihydroneopterin aldolase Coenzyme metabolism 152999067 Common - MiaB-like tRNA modifying enzyme YliG Shew185_0517 233 COG0621 MiaB, 2-methylthioadenine synthetase Translation, ribosomal structure and biogenesis 153001964 Common - methyl-accepting chemotaxis sensory transducer Shew185_3455 147 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 152999694 Common - Rhodanese domain protein Shew185_1160 143 COG2897 SseA, Rhodanese-related sulfurtransferase Inorganic ion transport and metabolism 152998608 Common - Pirin domain protein Shew185_0053 143 COG1741 COG1741, Pirin-related protein General function prediction only 152999229 Common - 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family Shew185_0690 103 COG1778 COG1778, Low specificity phosphatase (HAD superfamily) General function prediction only 153000970 Common - DNA polymerase III, delta prime subunit Shew185_2451 216 COG0470 HolB, ATPase involved in DNA replication DNA replication, recombination, and repair 153001477 Common - putative CheW protein Shew185_2964 200 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153000818 Common - protein of unknown function DUF1315 Shew185_2298 21 COG3139 COG3139, Uncharacterized protein conserved in bacteria Function unknown 153002755 Common - hypothetical protein Shew185_4257 2 None None None 152999808 Common - extracellular solute-binding protein family 3 Shew185_1275 76 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 153002044 Common - Citrate transporter Shew185_3535 42 COG1055 ArsB, Na+/H+ antiporter NhaD and related arsenite permeases Inorganic ion transport and metabolism 152998754 Common - ribosomal protein L22 Shew185_0201 218 COG0091 RplV, Ribosomal protein L22 Translation, ribosomal structure and biogenesis 152999619 Common - putative lipoprotein Shew185_1085 125 COG4105 ComL, DNA uptake lipoprotein General function prediction only 152999138 Common - transposase IS4 family protein Shew185_0594 32 COG5433 COG5433, Transposase DNA replication, recombination, and repair 152999498 Common - Na dependent nucleoside transporter domain protein Shew185_0963 68 COG1972 NupC, Nucleoside permease Nucleotide transport and metabolism 153001210 Common - acetate kinase Shew185_2693 162 COG0282 ackA, Acetate kinase Energy production and conversion 152998831 Common - molybdenum cofactor biosynthesis protein C Shew185_0278 195 COG0315 MoaC, Molybdenum cofactor biosynthesis enzyme Coenzyme metabolism 153000674 Common - Transketolase central region Shew185_2150 213 COG0022 AcoB, Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit Energy production and conversion 152999297 Nonpathogen - hypothetical protein Shew185_0758 1 None None None 153001715 Nonpathogen - hypothetical protein Shew185_3205 2 None None None 153002810 Common - GCN5-related N-acetyltransferase Shew185_4314 5 COG3375 COG3375, Uncharacterized conserved protein Function unknown 153000138 Common - protein of unknown function DUF463 YcjX family protein Shew185_1609 42 COG3106 COG3106, Predicted ATPase General function prediction only 152998951 Common - cell division protein FtsW Shew185_0400 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 152999076 Nonpathogen - hypothetical protein Shew185_0526 2 None None None 153002556 Common - carbohydrate kinase, thermoresistant glucokinase family Shew185_4056 80 COG3265 GntK, Gluconate kinase Carbohydrate transport and metabolism 153002770 Common - type III restriction protein res subunit Shew185_4273 44 COG1061 SSL2, DNA or RNA helicases of superfamily II Transcription / DNA replication, recombination, and repair 153001850 Common - ABC transporter related Shew185_3341 249 COG4604 CeuD, ABC-type enterochelin transport system, ATPase component Inorganic ion transport and metabolism 153002590 Common - argininosuccinate lyase Shew185_4091 226 COG0165 ArgH, Argininosuccinate lyase Amino acid transport and metabolism 152999220 Common - magnesium transporter Shew185_0681 175 COG2239 MgtE, Mg/Co/Ni transporter MgtE (contains CBS domain) Inorganic ion transport and metabolism 153000860 Common - sodium/sulphate symporter Shew185_2340 110 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 153002572 Common - transport-associated Shew185_4072 64 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 152999414 Common - hypothetical protein Shew185_0878 5 None None None 152999600 Common - sulfate ABC transporter, periplasmic sulfate-binding protein Shew185_1066 89 COG4150 CysP, ABC-type sulfate transport system, periplasmic component Inorganic ion transport and metabolism 153002341 Common - hypothetical protein Shew185_3835 3 None None None 153002057 Common - protein of unknown function DUF306 Meta and HslJ Shew185_3548 29 COG3187 HslJ, Heat shock protein Posttranslational modification, protein turnover, chaperones 153000118 Common - peptidyl-prolyl cis-trans isomerase cyclophilin type Shew185_1589 201 COG0652 PpiB, Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family Posttranslational modification, protein turnover, chaperones 153000887 Common - Glutathione S-transferase domain Shew185_2367 28 COG0625 Gst, Glutathione S-transferase Posttranslational modification, protein turnover, chaperones 152999981 Common - undecaprenyl diphosphate synthase Shew185_1449 242 COG0020 UppS, Undecaprenyl pyrophosphate synthase Lipid metabolism 152999053 Common - Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase Shew185_0503 201 COG0388 COG0388, Predicted amidohydrolase General function prediction only 152999196 Common - protein of unknown function DUF134 Shew185_0656 37 COG1342 COG1342, Predicted DNA-binding proteins General function prediction only 153002733 Common - PepSY-associated TM helix domain protein Shew185_4235 35 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 153000617 Common - hypothetical protein Shew185_2093 3 None None None 153002701 Common - transcription elongation factor GreB Shew185_4203 197 COG0782 GreA, Transcription elongation factor Transcription 153002822 Common - SNARE associated Golgi protein Shew185_4326 83 COG0398 COG0398, Uncharacterized conserved protein Function unknown 153001309 Common - protein of unknown function DUF541 Shew185_2793 27 COG2859 COG2859, Uncharacterized protein conserved in bacteria Function unknown 152999120 Nonpathogen - hypothetical protein Shew185_0573 1 None None None 152998710 Common - general secretion pathway protein L Shew185_0157 29 COG3297 PulL, Type II secretory pathway, component PulL Intracellular trafficking and secretion 152999988 Common - beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ Shew185_1456 187 COG0764 FabA, 3-hydroxymyristoyl/3-hydroxydecanoyl-(acyl carrier protein) dehydratases Lipid metabolism 153000324 Common - DoxX family protein Shew185_1799 40 COG2259 COG2259, Predicted membrane protein Function unknown 152999193 Common - hypothetical protein Shew185_0653 5 None None None 153000209 Common - phage integrase family protein Shew185_1683 213 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 153000728 Common - DsrE family protein Shew185_2207 38 COG2923 DsrF, Uncharacterized protein involved in the oxidation of intracellular sulfur Inorganic ion transport and metabolism 153002478 Nonpathogen - hypothetical protein Shew185_3975 1 None None None 152999508 Common - methionine synthase Shew185_0973 179 COG1410 MetH, Methionine synthase I, cobalamin-binding domain Amino acid transport and metabolism 153000972 Common - aminodeoxychorismate lyase Shew185_2453 185 COG1559 COG1559, Predicted periplasmic solute-binding protein General function prediction only 153001706 Common - peptidase S8 and S53 subtilisin kexin sedolisin Shew185_3194 104 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 152999692 Common - hypothetical protein Shew185_1158 7 COG0484 DnaJ, DnaJ-class molecular chaperone with C-terminal Zn finger domain Posttranslational modification, protein turnover, chaperones 153000906 Common - cysteine desulfurase IscS Shew185_2386 240 COG1104 NifS, Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes Amino acid transport and metabolism 153000510 Common - Radical SAM domain protein Shew185_1985 21 COG0535 COG0535, Predicted Fe-S oxidoreductases General function prediction only 153001612 Common - amino acid permease-associated region Shew185_3099 118 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 153000838 Common - thiazole biosynthesis protein ThiH Shew185_2318 53 COG1060 ThiH, Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes Coenzyme metabolism / General function prediction only 153002395 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Shew185_3889 44 COG2764 PhnB, Uncharacterized protein conserved in bacteria Function unknown 152999095 Nonpathogen - hypothetical protein Shew185_0545 1 None None None 153002131 Common - nodulation protein L Shew185_3624 92 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 153001934 Common - protein of unknown function DUF6 transmembrane Shew185_3425 111 COG0697 RhaT, Permeases of the drug/metabolite transporter (DMT) superfamily Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only 153002496 Common - hypothetical protein Shew185_3993 1 None None None 152999437 Common - Uncharacterized protein UPF0065 Shew185_0901 73 COG3181 COG3181, Uncharacterized protein conserved in bacteria Function unknown 152999397 Common - glutathione-dependent formaldehyde-activating GFA Shew185_0861 66 COG3791 COG3791, Uncharacterized conserved protein Function unknown 153000529 Common - DEAD/DEAH box helicase domain protein Shew185_2004 236 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 152999284 Common - phage integrase family protein Shew185_0745 27 COG0582 XerC, Integrase DNA replication, recombination, and repair 152999643 Common - hypothetical protein Shew185_1109 5 None None None 153000842 Common - thiamine-phosphate pyrophosphorylase Shew185_2322 212 COG0351 ThiD, Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase Coenzyme metabolism 153002128 Common - hypothetical protein Shew185_3621 1 None None None 152999617 Common - globin Shew185_1083 130 COG1017 Hmp, Hemoglobin-like flavoprotein Energy production and conversion 152998861 Common - hypothetical protein Shew185_0309 1 None None None 152999365 Common - methylation site containing protein Shew185_0829 54 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 153000708 Common - Phenazine biosynthesis PhzC/PhzF protein Shew185_2184 69 COG0384 COG0384, Predicted epimerase, PhzC/PhzF homolog General function prediction only 153000034 Common - protein of unknown function DUF6 transmembrane Shew185_1502 114 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 153001311 Common - acriflavin resistance protein Shew185_2795 177 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 152998749 Common - ribosomal protein L3 Shew185_0196 234 COG0087 RplC, Ribosomal protein L3 Translation, ribosomal structure and biogenesis 153002543 Common - hypothetical protein Shew185_4043 1 None None None 153000473 Common - iron-containing alcohol dehydrogenase Shew185_1948 199 COG1454 EutG, Alcohol dehydrogenase, class IV Energy production and conversion 153000255 Common - phosphoribosylformylglycinamidine cyclo-ligase Shew185_1730 230 COG0150 PurM, Phosphoribosylaminoimidazole (AIR) synthetase Nucleotide transport and metabolism 153001073 Nonpathogen - hypothetical protein Shew185_2556 1 None None None 153002436 Common - dihydrolipoamide dehydrogenase Shew185_3932 243 COG1249 Lpd, Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes Energy production and conversion 152999990 Common - lipid-A-disaccharide synthase Shew185_1458 139 COG0763 LpxB, Lipid A disaccharide synthetase Cell envelope biogenesis, outer membrane 153001553 Common - alanine racemase domain protein Shew185_3040 199 COG0325 COG0325, Predicted enzyme with a TIM-barrel fold General function prediction only 153002457 Common - hypothetical protein Shew185_3954 3 None None None 152998868 Common - hypothetical protein Shew185_0316 2 None None None 152998742 Common - DNA-directed RNA polymerase, beta subunit Shew185_0189 249 COG0085 RpoB, DNA-directed RNA polymerase, beta subunit/140 kD subunit Transcription 152999596 Common - AAA ATPase central domain protein Shew185_1062 249 COG0464 SpoVK, ATPases of the AAA+ class Posttranslational modification, protein turnover, chaperones 153000872 Common - major facilitator superfamily MFS_1 Shew185_2352 60 COG2814 AraJ, Arabinose efflux permease Carbohydrate transport and metabolism 153000531 Common - hypothetical protein Shew185_2006 1 None None None 153001656 Nonpathogen - hypothetical protein Shew185_3143 1 None None None 153002324 Common - hypothetical protein Shew185_3818 38 None None None 152999273 Common - hypothetical protein Shew185_0734 6 None None None 153002024 Common - transposase Shew185_3515 9 None None None 153001867 Common - hypothetical protein Shew185_3358 2 None None None 152998806 Common - integral membrane sensor signal transduction histidine kinase Shew185_0253 220 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153000653 Common - transcriptional regulator, RpiR family Shew185_2129 92 COG1737 RpiR, Transcriptional regulators Transcription 153002708 Common - hypothetical protein Shew185_4210 4 None None None 153000291 Common - hypothetical protein Shew185_1766 7 None None None 152998825 Common - diguanylate cyclase Shew185_0272 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152999183 Common - acriflavin resistance protein Shew185_0640 176 COG0841 AcrB, Cation/multidrug efflux pump Defense mechanisms 153001451 Common - flagellar motor switch protein FliG Shew185_2935 125 COG1536 FliG, Flagellar motor switch protein Cell motility and secretion 152999602 Common - hypothetical protein Shew185_1068 5 None None None 153000012 Common - 4a-hydroxytetrahydrobiopterin dehydratase Shew185_1480 88 COG2154 COG2154, Pterin-4a-carbinolamine dehydratase Coenzyme metabolism 152999127 Common - Resolvase domain protein Shew185_0580 132 COG1961 PinR, Site-specific recombinases, DNA invertase Pin homologs DNA replication, recombination, and repair 152998947 Common - UDP-N-acetylmuramyl-tripeptide synthetase Shew185_0396 211 COG0769 MurE, UDP-N-acetylmuramyl tripeptide synthase Cell envelope biogenesis, outer membrane 153002013 Common - hypothetical protein Shew185_3504 3 None None None 152999541 Common - aldehyde dehydrogenase Shew185_1007 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 153000664 Common - hypothetical protein Shew185_2140 23 COG4394 COG4394, Uncharacterized protein conserved in bacteria Function unknown 153001049 Common - NADH:flavin oxidoreductase/NADH oxidase Shew185_2530 178 COG1902 NemA, NADH:flavin oxidoreductases, Old Yellow Enzyme family Energy production and conversion 153002848 Common - adenosine deaminase Shew185_4352 115 COG1816 Add, Adenosine deaminase Nucleotide transport and metabolism 153001129 Common - GCN5-related N-acetyltransferase Shew185_2612 88 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 153001637 Common - alanyl-tRNA synthetase Shew185_3124 249 COG0013 AlaS, Alanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153000142 Common - hypothetical protein Shew185_1613 11 None None None 152999965 Common - hypothetical protein Shew185_1433 3 None None None 152999266 Nonpathogen - hypothetical protein Shew185_0727 1 None None None 152999090 Common - transcriptional regulator, MarR family Shew185_0540 99 COG1846 MarR, Transcriptional regulators Transcription 152998946 Common - Peptidoglycan glycosyltransferase Shew185_0395 207 COG0768 FtsI, Cell division protein FtsI/penicillin-binding protein 2 Cell envelope biogenesis, outer membrane 153001693 Common - efflux transporter, RND family, MFP subunit Shew185_3181 154 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153000054 Common - putative periplasmic protein Shew185_1524 6 None None None 153001977 Common - Catalase Shew185_3468 126 COG0753 KatE, Catalase Inorganic ion transport and metabolism 153001191 Common - hypothetical protein Shew185_2674 52 COG4327 COG4327, Predicted membrane protein Function unknown 152999082 Common - 4Fe-4S ferredoxin iron-sulfur binding domain protein Shew185_0532 167 COG0437 HybA, Fe-S-cluster-containing hydrogenase components 1 Energy production and conversion 153000809 Common - HAD-superfamily hydrolase, subfamily IA, variant 1 Shew185_2289 148 COG0546 Gph, Predicted phosphatases General function prediction only 152999688 Common - regulatory protein GntR HTH Shew185_1154 134 COG2186 FadR, Transcriptional regulators Transcription 152999724 Common - ribosomal protein S21 Shew185_1191 99 COG0828 RpsU, Ribosomal protein S21 Translation, ribosomal structure and biogenesis 153002778 Common - Fusaric acid resistance protein conserved region Shew185_4282 55 COG1289 COG1289, Predicted membrane protein Function unknown 152999342 Common - peptidase M50 Shew185_0803 29 COG1994 SpoIVFB, Zn-dependent proteases General function prediction only 153002686 Common - protoheme IX farnesyltransferase Shew185_4188 182 COG0109 CyoE, Polyprenyltransferase (cytochrome oxidase assembly factor) Posttranslational modification, protein turnover, chaperones 152999269 Nonpathogen - hypothetical protein Shew185_0730 1 None None None 153002265 Common - Stringent starvation protein B Shew185_3759 64 COG2969 SspB, Stringent starvation protein B General function prediction only 153002169 Common - protein of unknown function DUF985 Shew185_3662 57 COG3542 COG3542, Uncharacterized conserved protein Function unknown 153001069 Common - transcriptional regulator, LysR family Shew185_2551 60 COG0583 LysR, Transcriptional regulator Transcription 153001130 Common - recombination protein RecR Shew185_2613 204 COG0353 RecR, Recombinational DNA repair protein (RecF pathway) DNA replication, recombination, and repair 152999850 Common - transcriptional regulator, MarR family Shew185_1318 120 COG1846 MarR, Transcriptional regulators Transcription 153001276 Common - hypothetical protein Shew185_2760 21 COG3170 FimV, Tfp pilus assembly protein FimV Cell motility and secretion / Intracellular trafficking and secretion 152999555 Common - TonB-dependent heme/hemoglobin receptor family protein Shew185_1021 81 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 153002052 Common - GCN5-related N-acetyltransferase Shew185_3543 30 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 153001385 Common - hypothetical protein Shew185_2869 39 COG1228 HutI, Imidazolonepropionase and related amidohydrolases Secondary metabolites biosynthesis, transport, and catabolism 152999673 Common - tryptophan halogenase Shew185_1139 16 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 153000181 Common - hypothetical protein Shew185_1654 2 None None None 153002487 Common - type I secretion membrane fusion protein, HlyD family Shew185_3984 118 COG1566 EmrA, Multidrug resistance efflux pump Defense mechanisms 153000538 Common - transcriptional regulator, LysR family Shew185_2013 192 COG0583 LysR, Transcriptional regulator Transcription 153000494 Nonpathogen - hypothetical protein Shew185_1969 1 None None None 153001441 Common - flagellar biosynthetic protein FliQ Shew185_2925 115 COG1987 FliQ, Flagellar biosynthesis pathway, component FliQ Cell motility and secretion / Intracellular trafficking and secretion 153000433 Common - hydrogenase accessory protein HypB Shew185_1908 124 COG0378 HypB, Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase Posttranslational modification, protein turnover, chaperones / Transcription 153002679 Common - Cytochrome c oxidase subunit I type Shew185_4181 175 COG0843 CyoB, Heme/copper-type cytochrome/quinol oxidases, subunit 1 Energy production and conversion 153002233 Common - sodium:dicarboxylate symporter Shew185_3727 164 COG1301 GltP, Na+/H+-dicarboxylate symporters Energy production and conversion 153001438 Common - flagellar biosynthesis protein FlhA Shew185_2922 127 COG1298 FlhA, Flagellar biosynthesis pathway, component FlhA Cell motility and secretion / Intracellular trafficking and secretion 152999072 Common - hypothetical protein Shew185_0522 24 None None None 152999427 Common - protein of unknown function DUF350 Shew185_0891 5 None None None 152999897 Common - PAS/PAC sensor signal transduction histidine kinase Shew185_1365 222 COG5002 VicK, Signal transduction histidine kinase Signal transduction mechanisms 153002812 Common - two component, sigma54 specific, transcriptional regulator, Fis family Shew185_4316 221 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153000504 Common - phospholipase D/transphosphatidylase Shew185_1979 58 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 153000800 Common - cytidylate kinase Shew185_2280 204 COG0283 Cmk, Cytidylate kinase Nucleotide transport and metabolism 153000934 Common - hypothetical protein Shew185_2415 2 COG4899 COG4899, Uncharacterized protein conserved in bacteria Function unknown 152999153 Common - transposase IS66 Shew185_0610 66 COG3436 COG3436, Transposase and inactivated derivatives DNA replication, recombination, and repair 152999746 Common - peptidase M23B Shew185_1213 187 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 153000076 Common - alpha/beta hydrolase fold Shew185_1547 156 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152999477 Common - DSBA oxidoreductase Shew185_0941 44 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 153002423 Common - hypothetical protein Shew185_3917 3 None None None 153000277 Common - 8-amino-7-oxononanoate synthase Shew185_1752 189 COG0156 BioF, 7-keto-8-aminopelargonate synthetase and related enzymes Coenzyme metabolism 153000137 Common - phage shock protein C, PspC Shew185_1608 39 COG1983 PspC, Putative stress-responsive transcriptional regulator Transcription / Signal transduction mechanisms 152999112 Common - AAA ATPase Shew185_0562 149 COG0507 RecD, ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member DNA replication, recombination, and repair 152998630 Common - AMP-dependent synthetase and ligase Shew185_0075 213 COG1022 FAA1, Long-chain acyl-CoA synthetases (AMP-forming) Lipid metabolism 153000786 Common - beta-lactamase Shew185_2266 116 COG1680 AmpC, Beta-lactamase class C and other penicillin binding proteins Defense mechanisms 153001833 Common - lipoic acid synthetase Shew185_3324 190 COG0320 LipA, Lipoate synthase Coenzyme metabolism 153000952 Common - NAD-glutamate dehydrogenase Shew185_2433 77 COG2902 COG2902, NAD-specific glutamate dehydrogenase Amino acid transport and metabolism 153001599 Common - Cytosine deaminase Shew185_3086 200 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 153001992 Common - hypothetical protein Shew185_3483 51 COG2513 PrpB, PEP phosphonomutase and related enzymes Carbohydrate transport and metabolism 152999232 Common - protein of unknown function DUF140 Shew185_0693 151 COG0767 Ttg2B, ABC-type transport system involved in resistance to organic solvents, permease component Secondary metabolites biosynthesis, transport, and catabolism 152999390 Common - protein of unknown function UPF0270 Shew185_0854 1 None None None 153002659 Common - RNA polymerase, sigma 32 subunit, RpoH Shew185_4161 216 COG0568 RpoD, DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) Transcription 153002533 Common - protein of unknown function DUF904 Shew185_4033 1 None None None 153000585 Common - electron transport complex, RnfABCDGE type, G subunit Shew185_2061 58 COG4659 RnfG, Predicted NADH:ubiquinone oxidoreductase, subunit RnfG Energy production and conversion 152998857 Common - two component transcriptional regulator, winged helix family Shew185_0305 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153001819 Common - protein of unknown function DUF1451 Shew185_3310 20 None None None 153001095 Common - diguanylate cyclase Shew185_2578 177 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152999911 Common - transcriptional regulator, TetR family Shew185_1379 85 COG1309 AcrR, Transcriptional regulator Transcription 152999795 Common - hypothetical protein Shew185_1262 1 COG3671 COG3671, Predicted membrane protein Function unknown 153000215 Nonpathogen - hypothetical protein Shew185_1689 1 None None None 152999655 Common - isoleucyl-tRNA synthetase Shew185_1121 249 COG0060 IleS, Isoleucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 152999779 Common - GTP-binding protein Era Shew185_1246 232 COG1159 Era, GTPase General function prediction only 153001997 Common - thioesterase superfamily protein Shew185_3488 59 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 153002677 Common - hypothetical protein Shew185_4179 19 COG5404 SulA, SOS-response cell division inhibitor, blocks FtsZ ring formation Cell division and chromosome partitioning 152999356 Common - translation elongation factor G Shew185_0820 249 COG0480 FusA, Translation elongation factors (GTPases) Translation, ribosomal structure and biogenesis 153002864 Common - ATP synthase F1, delta subunit Shew185_4368 136 COG0712 AtpH, F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) Energy production and conversion 152999417 Common - SH3 type 3 domain protein Shew185_0881 32 COG3103 COG3103, SH3 domain protein Signal transduction mechanisms 153002085 Common - peptidase M19 renal dipeptidase Shew185_3577 102 COG2355 COG2355, Zn-dependent dipeptidase, microsomal dipeptidase homolog Amino acid transport and metabolism 153000878 Common - hypothetical protein Shew185_2358 26 COG0226 PstS, ABC-type phosphate transport system, periplasmic component Inorganic ion transport and metabolism 152999908 Common - Fmu (Sun) domain protein Shew185_1376 207 COG0144 Sun, tRNA and rRNA cytosine-C5-methylases Translation, ribosomal structure and biogenesis 152999330 Common - UBA/THIF-type NAD/FAD binding protein Shew185_0791 135 COG1179 COG1179, Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 Coenzyme metabolism 153001289 Common - peptidase M16 domain protein Shew185_2773 165 COG1025 Ptr, Secreted/periplasmic Zn-dependent peptidases, insulinase-like Posttranslational modification, protein turnover, chaperones 153002204 Common - hypothetical protein Shew185_3697 8 None None None 153002806 Common - TonB-dependent receptor plug Shew185_4310 119 COG1629 CirA, Outer membrane receptor proteins, mostly Fe transport Inorganic ion transport and metabolism 152999039 Common - hypothetical protein Shew185_0489 2 None None None 153001735 Common - Integrase catalytic region Shew185_3226 137 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 153000032 Common - ABC transporter related Shew185_1500 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 152999561 Common - transcriptional regulator, Fis family Shew185_1027 184 COG3604 FhlA, Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains Transcription / Signal transduction mechanisms 152998663 Common - hypothetical protein Shew185_0110 1 None None None 153000359 Common - alpha-L-glutamate ligase, RimK family Shew185_1834 130 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 153001408 Common - glycosyl transferase group 1 Shew185_2892 171 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 153000270 Common - porin Shew185_1745 28 None None None 153001507 Common - phosphoribosylformylglycinamidine synthase Shew185_2994 232 COG0046 PurL, Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Nucleotide transport and metabolism 152998972 Common - Ribonuclease E inhibitor RraA Shew185_0421 93 COG0684 MenG, Demethylmenaquinone methyltransferase Coenzyme metabolism 153001186 Common - 3-oxoacyl-(acyl-carrier-protein) synthase III Shew185_2669 213 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 152999821 Common - protein of unknown function DUF28 Shew185_1289 212 COG0217 COG0217, Uncharacterized conserved protein Function unknown 153001471 Common - flagellar basal-body rod protein FlgF Shew185_2958 123 COG4787 FlgF, Flagellar basal body rod protein Cell motility and secretion 152999665 Common - type IV pilus biogenesis protein, putative Shew185_1131 6 COG4970 FimT, Tfp pilus assembly protein FimT Cell motility and secretion / Intracellular trafficking and secretion 152999247 Common - RNA methyltransferase, TrmH family, group 3 Shew185_0708 215 COG0566 SpoU, rRNA methylases Translation, ribosomal structure and biogenesis 153000309 Common - SirA family protein Shew185_1784 17 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 153000314 Common - peptidase M61 domain protein Shew185_1789 57 COG3975 COG3975, Predicted protease with the C-terminal PDZ domain General function prediction only 153000594 Nonpathogen - hypothetical protein Shew185_2070 1 None None None 153000715 Common - type I restriction-modification system, M subunit Shew185_2193 161 COG0286 HsdM, Type I restriction-modification system methyltransferase subunit Defense mechanisms 152999648 Common - amino acid carrier protein Shew185_1114 114 COG1115 AlsT, Na+/alanine symporter Amino acid transport and metabolism 152998891 Common - phosphopantetheine-binding Shew185_0339 83 COG0236 AcpP, Acyl carrier protein Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 152999612 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Shew185_1078 9 None None None 152999828 Common - DEAD/DEAH box helicase domain protein Shew185_1296 241 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 153000042 Common - transcriptional regulator, TetR family Shew185_1512 73 COG1309 AcrR, Transcriptional regulator Transcription 153002299 Common - response regulator receiver protein Shew185_3793 201 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 152999967 Common - protein of unknown function DUF446 Shew185_1435 32 COG3098 COG3098, Uncharacterized protein conserved in bacteria Function unknown 153001417 Common - sugar transferase Shew185_2901 181 COG2148 WcaJ, Sugar transferases involved in lipopolysaccharide synthesis Cell envelope biogenesis, outer membrane 153002566 Common - putative orphan protein Shew185_4066 2 None None None 153002329 Common - hypothetical protein Shew185_3823 1 None None None 152999883 Common - hypothetical protein Shew185_1351 34 COG3571 COG3571, Predicted hydrolase of the alpha/beta-hydrolase fold General function prediction only 152998875 Common - GCN5-related N-acetyltransferase Shew185_0323 46 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 152998871 Common - NAD(P)H dehydrogenase (quinone) Shew185_0319 99 COG1182 AcpD, Acyl carrier protein phosphodiesterase Lipid metabolism 152999147 Common - two component transcriptional regulator, winged helix family Shew185_0604 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 152999681 Common - hypothetical protein Shew185_1147 18 COG4299 COG4299, Uncharacterized protein conserved in bacteria Function unknown 152999875 Common - deoxyxylulose-5-phosphate synthase Shew185_1343 214 COG1154 Dxs, Deoxyxylulose-5-phosphate synthase Coenzyme metabolism / Lipid metabolism 153000989 Common - NUDIX hydrolase Shew185_2470 48 COG1051 COG1051, ADP-ribose pyrophosphatase Nucleotide transport and metabolism 153001528 Common - GCN5-related N-acetyltransferase Shew185_3015 31 COG1246 ArgA, N-acetylglutamate synthase and related acetyltransferases Amino acid transport and metabolism 153001251 Common - intracellular septation protein A Shew185_2735 92 COG2917 COG2917, Intracellular septation protein A Cell division and chromosome partitioning 152999889 Common - 5'-3' exonuclease Shew185_1357 216 COG0258 Exo, 5'-3' exonuclease (including N-terminal domain of PolI) DNA replication, recombination, and repair 153001201 Common - RDD domain containing protein Shew185_2684 3 COG1714 COG1714, Predicted membrane protein/domain Function unknown 153002156 Common - Azurin Shew185_3649 20 COG3241 COG3241, Azurin Energy production and conversion 152999001 Common - response regulator receiver protein Shew185_0451 205 COG4566 TtrR, Response regulator Signal transduction mechanisms 153000875 Common - peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin Shew185_2355 26 COG1876 VanY, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 153001621 Common - hypothetical protein Shew185_3108 7 None None None 153000019 Common - hypothetical protein Shew185_1487 24 COG3126 COG3126, Uncharacterized protein conserved in bacteria Function unknown 153000643 Common - hypothetical protein Shew185_2119 5 None None None 153000059 Common - hypothetical protein Shew185_1529 20 None None None 153001030 Common - Succinate dehydrogenase hydrophobic membrane anchor Shew185_2511 52 COG2142 SdhD, Succinate dehydrogenase, hydrophobic anchor subunit Energy production and conversion 152998937 Common - 3-isopropylmalate dehydrogenase Shew185_0386 222 COG0473 LeuB, Isocitrate/isopropylmalate dehydrogenase Amino acid transport and metabolism 153000746 Common - riboflavin synthase, alpha subunit Shew185_2225 208 COG0307 RibC, Riboflavin synthase alpha chain Coenzyme metabolism 153000419 Common - septum site-determining protein MinD Shew185_1894 139 COG2894 MinD, Septum formation inhibitor-activating ATPase Cell division and chromosome partitioning 153001050 Common - transcriptional regulator, LysR family Shew185_2531 168 COG0583 LysR, Transcriptional regulator Transcription 153001330 Common - NADH:ubiquinone oxidoreductase complex I intermediate-associated protein 30 Shew185_2814 22 None None None 152999447 Common - lipid A biosynthesis lauroyl (or palmitoleoyl) acyltransferase Shew185_0911 100 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 153000844 Common - hypothetical protein Shew185_2324 1 None None None 152999783 Common - protein of unknown function DUF962 Shew185_1250 26 COG4539 COG4539, Predicted membrane protein Function unknown 153001677 Common - putative protein-disulfide isomerase Shew185_3165 24 COG3531 COG3531, Predicted protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 153002037 Common - efflux transporter, RND family, MFP subunit Shew185_3528 87 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 152998843 Common - protein of unknown function UPF0057 Shew185_0290 1 COG0401 COG0401, Uncharacterized homolog of Blt101 Function unknown 152998581 Common - methionyl-tRNA formyltransferase Shew185_0026 223 COG0223 Fmt, Methionyl-tRNA formyltransferase Translation, ribosomal structure and biogenesis 152999306 Common - hypothetical protein Shew185_0767 10 None None None 153002373 Common - transcriptional regulator, CadC Shew185_3867 5 COG3710 CadC, DNA-binding winged-HTH domains Transcription 153000085 Common - Glyoxalase/bleomycin resistance protein/dioxygenase Shew185_1556 22 COG3324 COG3324, Predicted enzyme related to lactoylglutathione lyase General function prediction only 153002772 Common - hypothetical protein Shew185_4275 31 COG1404 AprE, Subtilisin-like serine proteases Posttranslational modification, protein turnover, chaperones 153002071 Common - NADH:ubiquinone oxidoreductase, subunit B Shew185_3563 76 COG1805 NqrB, Na+-transporting NADH:ubiquinone oxidoreductase, subunit NqrB Energy production and conversion 153001200 Common - Beta-ketoacyl-acyl-carrier-protein synthase I Shew185_2683 181 COG0332 FabH, 3-oxoacyl- acyl-carrier-protein 153002333 Common - RNA-metabolising metallo-beta-lactamase Shew185_3827 130 COG1236 YSH1, Predicted exonuclease of the beta-lactamase fold involved in RNA processing Translation, ribosomal structure and biogenesis 153001733 Common - membrane protein Shew185_3224 2 COG3726 AhpA, Uncharacterized membrane protein affecting hemolysin expression General function prediction only 152999337 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Shew185_0798 154 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 153002270 Common - HflC protein Shew185_3764 210 COG0330 HflC, Membrane protease subunits, stomatin/prohibitin homologs Posttranslational modification, protein turnover, chaperones 153002875 Common - 60 kDa inner membrane insertion protein Shew185_4379 214 COG0706 YidC, Preprotein translocase subunit YidC Intracellular trafficking and secretion 153002171 Common - protein of unknown function DUF181 Shew185_3664 53 COG1944 COG1944, Uncharacterized conserved protein Function unknown 152999715 Common - Alanine racemase Shew185_1181 128 COG1609 PurR, Transcriptional regulators Transcription 153002851 Common - diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s) Shew185_4355 179 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 153001820 Common - leucyl-tRNA synthetase Shew185_3311 249 COG0495 LeuS, Leucyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153000605 Common - hypothetical protein Shew185_2081 1 None None None 153000997 Common - transcriptional regulator, MarR family Shew185_2478 121 COG1846 MarR, Transcriptional regulators Transcription 152998568 Common - SirA family protein Shew185_0013 91 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 152999880 Common - thiamine biosynthesis/tRNA modification protein ThiI Shew185_1348 94 COG0301 ThiI, Thiamine biosynthesis ATP pyrophosphatase Coenzyme metabolism 153001877 Nonpathogen - hypothetical protein Shew185_3368 1 None None None 153000486 Common - hypothetical protein Shew185_1961 1 None None None 152999011 Common - hypothetical protein Shew185_0461 15 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 152999957 Common - GTP cyclohydrolase I Shew185_1425 73 COG2904 COG2904, Uncharacterized protein conserved in bacteria Function unknown 153002286 Common - hypothetical protein Shew185_3780 9 None None None 153000776 Common - transcriptional regulator, MarR family Shew185_2256 73 COG1846 MarR, Transcriptional regulators Transcription 153000178 Common - anaerobic ribonucleoside-triphosphate reductase activating protein Shew185_1651 60 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 153002001 Common - peptide chain release factor 2 Shew185_3492 216 COG1186 PrfB, Protein chain release factor B Translation, ribosomal structure and biogenesis 152999140 Common - OmpA domain protein transmembrane region-containing protein Shew185_0596 1 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 152999636 Common - phosphoribosylaminoimidazole carboxylase, ATPase subunit Shew185_1102 191 COG0026 PurK, Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) Nucleotide transport and metabolism 153000341 Common - hypothetical protein Shew185_1816 3 None None None 153000691 Common - cytochrome c oxidase, cbb3-type, subunit III Shew185_2167 80 COG2010 CccA, Cytochrome c, mono- and diheme variants Energy production and conversion 152998622 Common - penicillin-binding protein 1C Shew185_0067 200 COG4953 PbpC, Membrane carboxypeptidase/penicillin-binding protein PbpC Cell envelope biogenesis, outer membrane 153002253 Common - putative transcriptional regulator, Crp/Fnr family Shew185_3747 167 COG0664 Crp, cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases Signal transduction mechanisms 153000602 Nonpathogen - hypothetical protein Shew185_2078 1 None None None 153001409 Nonpathogen - hypothetical protein Shew185_2893 1 None None None 152998598 Common - phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent Shew185_0043 125 COG0696 GpmI, Phosphoglyceromutase Carbohydrate transport and metabolism 152999791 Common - phospho-2-dehydro-3-deoxyheptonate aldolase Shew185_1258 107 COG0722 AroG, 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase Amino acid transport and metabolism 153000795 Common - orotidine 5'-phosphate decarboxylase Shew185_2275 165 COG0284 PyrF, Orotidine-5'-phosphate decarboxylase Nucleotide transport and metabolism 153000412 Common - hypothetical protein Shew185_1887 1 None None None 152998923 Common - peptidase S9 prolyl oligopeptidase active site domain protein Shew185_0372 119 COG1506 DAP2, Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Amino acid transport and metabolism 153002858 Common - TonB-dependent siderophore receptor Shew185_4362 113 COG4774 Fiu, Outer membrane receptor for monomeric catechols Inorganic ion transport and metabolism 153002575 Common - tryptophanyl-tRNA synthetase Shew185_4075 232 COG0180 TrpS, Tryptophanyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153001634 Common - valyl-tRNA synthetase Shew185_3121 249 COG0525 ValS, Valyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153001630 Common - permease YjgP/YjgQ family protein Shew185_3117 106 COG0795 COG0795, Predicted permeases General function prediction only 153000968 Common - hydrolase, TatD family Shew185_2449 238 COG0084 TatD, Mg-dependent DNase DNA replication, recombination, and repair 153001144 Common - hypothetical protein Shew185_2627 3 None None None 152999548 Common - hypothetical protein Shew185_1014 7 None None None 153001040 Common - hypothetical protein Shew185_2521 66 COG3034 COG3034, Uncharacterized protein conserved in bacteria Function unknown 153001108 Common - amino acid-binding ACT domain protein Shew185_2591 39 COG2716 GcvR, Glycine cleavage system regulatory protein Amino acid transport and metabolism 153001344 Common - two component, sigma54 specific, transcriptional regulator, Fis family Shew185_2828 221 COG2204 AtoC, Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains Signal transduction mechanisms 153001726 Common - TMAO reductase system periplasmic TorT Shew185_3216 17 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 153000441 Common - Redoxin domain protein Shew185_1916 194 COG0526 TrxA, Thiol-disulfide isomerase and thioredoxins Posttranslational modification, protein turnover, chaperones / Energy production and conversion 152999064 Common - hypothetical protein Shew185_0514 3 COG4623 COG4623, Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein Cell envelope biogenesis, outer membrane 153001374 Nonpathogen - hypothetical protein Shew185_2858 1 None None None 153002344 Common - radical SAM domain protein Shew185_3838 26 None None None 153001801 Common - protein-export membrane protein SecD Shew185_3292 207 COG0342 SecD, Preprotein translocase subunit SecD Intracellular trafficking and secretion 153000079 Common - hypothetical protein Shew185_1550 4 None None None 153000074 Common - hypothetical protein Shew185_1545 13 COG0407 HemE, Uroporphyrinogen-III decarboxylase Coenzyme metabolism 153001795 Common - dihydropteroate synthase Shew185_3286 218 COG0294 FolP, Dihydropteroate synthase and related enzymes Coenzyme metabolism 152998666 Common - hypothetical protein Shew185_0113 6 None None None 153002225 Common - two component transcriptional regulator, winged helix family Shew185_3719 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153002231 Common - Uncharacterized protein UPF0114 Shew185_3725 55 COG2862 COG2862, Predicted membrane protein Function unknown 152999321 Common - NUDIX hydrolase Shew185_0782 141 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 153002368 Common - Amidohydrolase 3 Shew185_3862 109 COG1574 COG1574, Predicted metal-dependent hydrolase with the TIM-barrel fold General function prediction only 152999762 Common - PTSINtr with GAF domain, PtsP Shew185_1229 235 COG3605 PtsP, Signal transduction protein containing GAF and PtsI domains Signal transduction mechanisms 153002311 Common - aldo/keto reductase Shew185_3805 181 COG4989 COG4989, Predicted oxidoreductase General function prediction only 153000941 Common - imidazole glycerol phosphate synthase, glutamine amidotransferase subunit Shew185_2422 214 COG0118 HisH, Glutamine amidotransferase Amino acid transport and metabolism 153001519 Common - hypothetical protein Shew185_3006 63 COG1426 COG1426, Uncharacterized protein conserved in bacteria Function unknown 153001371 Common - hypothetical protein Shew185_2855 1 None None None 152999103 Common - peptidase M28 Shew185_0553 53 COG2234 Iap, Predicted aminopeptidases General function prediction only 152999359 Common - Nitrate reductase cytochrome c-type subunit (NapB) Shew185_0823 40 COG3043 NapB, Nitrate reductase cytochrome c-type subunit Energy production and conversion 153002209 Common - ABC transporter related Shew185_3702 249 COG5265 ATM1, ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components Posttranslational modification, protein turnover, chaperones 153002065 Nonpathogen - hypothetical protein Shew185_3557 1 None None None 152999571 Common - ribosomal protein L27 Shew185_1037 215 COG0211 RpmA, Ribosomal protein L27 Translation, ribosomal structure and biogenesis 152999384 Common - Glutamate--tRNA ligase Shew185_0848 247 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 152999403 Common - Pirin domain protein Shew185_0867 148 COG1741 COG1741, Pirin-related protein General function prediction only 153000348 Nonpathogen - hypothetical protein Shew185_1823 1 None None None 153002834 Common - Three-deoxy-D-manno-octulosonic-acid transferase domain protein Shew185_4338 128 COG1519 KdtA, 3-deoxy-D-manno-octulosonic-acid transferase Cell envelope biogenesis, outer membrane 153001987 Common - membrane lipoprotein lipid attachment site Shew185_3478 41 COG3417 FlgN, Collagen-binding surface adhesin SpaP (antigen I/II family) General function prediction only 152998695 Common - peptidase M14 carboxypeptidase A Shew185_0142 22 COG2866 COG2866, Predicted carboxypeptidase Amino acid transport and metabolism 153002101 Common - sterol desaturase family protein Shew185_3594 76 COG3000 ERG3, Sterol desaturase Lipid metabolism 152999969 Common - hypothetical protein Shew185_1437 1 None None None 153001269 Common - DNA topoisomerase III Shew185_2753 247 COG0550 TopA, Topoisomerase IA DNA replication, recombination, and repair 153001494 Common - N-acylneuraminate cytidylyltransferase Shew185_2981 71 COG1083 NeuA, CMP-N-acetylneuraminic acid synthetase Cell envelope biogenesis, outer membrane 153001762 Common - transcriptional regulator, XRE family Shew185_3253 2 COG1396 HipB, Predicted transcriptional regulators Transcription 152999253 Common - ribosomal protein L9 Shew185_0714 205 COG0359 RplI, Ribosomal protein L9 Translation, ribosomal structure and biogenesis 153001222 Common - signal peptidase I Shew185_2706 204 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 152999733 Common - Peptidoglycan-binding domain 1 protein Shew185_1200 73 COG3267 ExeA, Type II secretory pathway, component ExeA (predicted ATPase) Intracellular trafficking and secretion 153000219 Nonpathogen - hypothetical protein Shew185_1693 1 None None None 153001879 Common - hypothetical protein Shew185_3370 8 None None None 153002623 Common - protein of unknown function DUF6 transmembrane Shew185_4124 111 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 153001594 Common - YheO domain protein Shew185_3081 49 COG2964 COG2964, Uncharacterized protein conserved in bacteria Function unknown 152999458 Common - monofunctional biosynthetic peptidoglycan transglycosylase Shew185_0922 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 153000661 Common - Na+ antiporter NhaC Shew185_2137 59 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 152998790 Common - GCN5-related N-acetyltransferase Shew185_0237 30 COG3153 COG3153, Predicted acetyltransferase General function prediction only 152999080 Common - pentapeptide repeat protein Shew185_0530 39 COG1357 COG1357, Uncharacterized low-complexity proteins Function unknown 153001004 Common - thioesterase superfamily protein Shew185_2485 132 COG1607 COG1607, Acyl-CoA hydrolase Lipid metabolism 153002545 Common - diguanylate cyclase Shew185_4045 178 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152999658 Common - hydroxymethylbutenyl pyrophosphate reductase Shew185_1124 188 COG0761 LytB, Penicillin tolerance protein Lipid metabolism / Cell envelope biogenesis, outer membrane 153001982 Common - peptidylprolyl isomerase FKBP-type Shew185_3473 134 COG0545 FkpA, FKBP-type peptidyl-prolyl cis-trans isomerases 1 Posttranslational modification, protein turnover, chaperones 153002419 Common - phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Shew185_3913 219 COG0138 PurH, AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) Nucleotide transport and metabolism 153000171 Common - hypothetical protein Shew185_1644 11 None None None 153000992 Common - adenylosuccinate lyase Shew185_2473 230 COG0015 PurB, Adenylosuccinate lyase Nucleotide transport and metabolism 153001163 Common - AMP-dependent synthetase and ligase Shew185_2646 225 COG0318 CaiC, Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153001810 Common - Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family Shew185_3301 133 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 153002089 Common - peptidase U32 Shew185_3582 140 COG0826 COG0826, Collagenase and related proteases Posttranslational modification, protein turnover, chaperones 153002815 Common - ABC transporter related Shew185_4319 249 COG1122 CbiO, ABC-type cobalt transport system, ATPase component Inorganic ion transport and metabolism 152998967 Common - twin-arginine translocation protein, TatA/E family subunit Shew185_0416 53 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 153000584 Common - electron transport complex, RnfABCDGE type, E subunit Shew185_2060 76 COG4660 RnfE, Predicted NADH:ubiquinone oxidoreductase, subunit RnfE Energy production and conversion 153002163 Common - MATE efflux family protein Shew185_3656 153 COG0534 NorM, Na+-driven multidrug efflux pump Defense mechanisms 152999219 Common - molybdenum ABC transporter, periplasmic molybdate-binding protein Shew185_0680 73 COG0725 ModA, ABC-type molybdate transport system, periplasmic component Inorganic ion transport and metabolism 153000322 Common - aminoglycoside phosphotransferase Shew185_1797 3 COG0510 CotS, Predicted choline kinase involved in LPS biosynthesis Cell envelope biogenesis, outer membrane 153001717 Common - metallophosphoesterase Shew185_3207 53 COG2908 COG2908, Uncharacterized protein conserved in bacteria Function unknown 152999408 Common - hypothetical protein Shew185_0872 2 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 152999915 Common - major facilitator superfamily MFS_1 Shew185_1383 96 COG2807 CynX, Cyanate permease Inorganic ion transport and metabolism 153001425 Common - FlhB domain protein Shew185_2909 46 COG2257 COG2257, Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB Function unknown 153001904 Common - hypothetical protein Shew185_3395 1 None None None 153001447 Common - flagellar hook-length control protein Shew185_2931 35 COG3144 FliK, Flagellar hook-length control protein Cell motility and secretion 153001155 Common - hypothetical protein Shew185_2638 2 None None None 153001606 Common - glycoside hydrolase family 18 Shew185_3093 53 COG3325 ChiA, Chitinase Carbohydrate transport and metabolism 153000634 Common - hypothetical protein Shew185_2110 11 None None None 153000793 Common - hypothetical protein Shew185_2273 29 COG3122 COG3122, Uncharacterized protein conserved in bacteria Function unknown 153001531 Common - GCN5-related N-acetyltransferase Shew185_3018 4 None None None 153001758 Common - hypothetical protein Shew185_3249 2 None None None 152999412 Common - DNA binding domain, excisionase family Shew185_0876 1 None None None 153000640 Common - hypothetical protein Shew185_2116 163 COG0602 NrdG, Organic radical activating enzymes Posttranslational modification, protein turnover, chaperones 152998836 Common - ABC transporter related Shew185_0283 249 COG3842 PotA, ABC-type spermidine/putrescine transport systems, ATPase components Amino acid transport and metabolism 152998816 Common - iron-containing alcohol dehydrogenase Shew185_0263 170 COG1979 COG1979, Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family Energy production and conversion 153000541 Common - hypothetical protein Shew185_2016 11 None None None 153001084 Common - protein of unknown function DUF450 Shew185_2567 3 COG4748 COG4748, Uncharacterized conserved protein Function unknown 153001891 Common - GP46 Shew185_3382 6 None None None 153001688 Common - globin Shew185_3176 24 COG2346 COG2346, Truncated hemoglobins General function prediction only 152999904 Common - protein of unknown function DUF6 transmembrane Shew185_1372 113 COG5006 COG5006, Predicted permease, DMT superfamily General function prediction only 152999349 Common - Deoxyribonuclease I Shew185_0810 33 COG2356 EndA, Endonuclease I DNA replication, recombination, and repair 153000263 Common - Pol-Pal system-associated acyl-CoA thioesterase Shew185_1738 139 COG0824 FcbC, Predicted thioesterase General function prediction only 152999868 Common - protein of unknown function DUF162 Shew185_1336 26 COG1556 COG1556, Uncharacterized conserved protein Function unknown 152999891 Common - diguanylate cyclase Shew185_1359 184 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 153000816 Common - Integrase catalytic region Shew185_2296 131 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 153000448 Common - glycosyl transferase family 2 Shew185_1923 57 COG2943 MdoH, Membrane glycosyltransferase Cell envelope biogenesis, outer membrane 153000628 Common - hypothetical protein Shew185_2104 5 None None None 152999125 Common - YD repeat protein Shew185_0578 39 COG3209 RhsA, Rhs family protein Cell envelope biogenesis, outer membrane 153000045 Common - ABC-2 type transporter Shew185_1515 164 COG0842 COG0842, ABC-type multidrug transport system, permease component Defense mechanisms 153001365 Common - Carbamoyl-phosphate synthase L chain ATP-binding Shew185_2849 232 COG4770 COG4770, Acetyl/propionyl-CoA carboxylase, alpha subunit Lipid metabolism 153002012 Common - Methyltransferase type 12 Shew185_3503 48 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 153001488 Common - DegT/DnrJ/EryC1/StrS aminotransferase Shew185_2975 190 COG0399 WecE, Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis Cell envelope biogenesis, outer membrane 153000406 Common - protein tyrosine phosphatase Shew185_1881 131 COG0394 Wzb, Protein-tyrosine-phosphatase Signal transduction mechanisms 153002798 Nonpathogen - hypothetical protein Shew185_4302 3 None None None 153000004 Common - hypothetical protein Shew185_1472 8 None None None 153000027 Common - short-chain dehydrogenase/reductase SDR Shew185_1495 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 153002033 Common - tyrosine recombinase XerD Shew185_3524 230 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 152998674 Common - protein of unknown function DUF833 Shew185_0121 48 COG3332 COG3332, Uncharacterized conserved protein Function unknown 152999521 Common - cell division protein ZipA Shew185_0986 14 COG0645 COG0645, Predicted kinase General function prediction only 153000364 Common - protein of unknown function DUF450 Shew185_1839 40 COG4748 COG4748, Uncharacterized conserved protein Function unknown 152998740 Common - ribosomal protein L10 Shew185_0187 205 COG0244 RplJ, Ribosomal protein L10 Translation, ribosomal structure and biogenesis 153001064 Common - formate dehydrogenase, gamma subunit Shew185_2546 62 COG2864 FdnI, Cytochrome b subunit of formate dehydrogenase Energy production and conversion 152999328 Common - porin Gram-negative type Shew185_0789 34 COG3203 OmpC, Outer membrane protein (porin) Cell envelope biogenesis, outer membrane 153000894 Common - acetolactate synthase, large subunit, biosynthetic type Shew185_2374 221 COG0028 IlvB, Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] Amino acid transport and metabolism / Coenzyme metabolism 152999093 Common - cytochrome c family protein Shew185_0543 58 COG2863 COG2863, Cytochrome c553 Energy production and conversion 153002443 Nonpathogen - methylation site containing protein Shew185_3940 1 COG4968 PilE, Tfp pilus assembly protein PilE Cell motility and secretion / Intracellular trafficking and secretion 153001013 Common - two component transcriptional regulator, winged helix family Shew185_2494 223 COG0745 OmpR, Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain Signal transduction mechanisms / Transcription 153000652 Common - pyruvate kinase Shew185_2128 220 COG0469 PykF, Pyruvate kinase Carbohydrate transport and metabolism 153001036 Common - uncharacterised conserved protein UCP029143 Shew185_2517 16 COG3097 COG3097, Uncharacterized protein conserved in bacteria Function unknown 153002573 Common - protein of unknown function DUF6 transmembrane Shew185_4073 110 COG2962 RarD, Predicted permeases General function prediction only 152999464 Common - sulfate adenylyltransferase, small subunit Shew185_0928 138 COG0175 CysH, 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Amino acid transport and metabolism / Coenzyme metabolism 153002597 Common - competence/damage-inducible protein CinA Shew185_4098 213 COG1058 CinA, Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA General function prediction only 153002113 Common - diguanylate phosphodiesterase Shew185_3606 160 COG2200 Rtn, FOG: EAL domain Signal transduction mechanisms 153002706 Common - methyl-accepting chemotaxis sensory transducer Shew185_4208 148 COG0840 Tar, Methyl-accepting chemotaxis protein Cell motility and secretion / Signal transduction mechanisms 153001044 Common - isocitrate dehydrogenase (NADP(+)) Shew185_2525 15 COG0720 COG0720, 6-pyruvoyl-tetrahydropterin synthase Coenzyme metabolism 153001393 Nonpathogen - hypothetical protein Shew185_2877 1 None None None 153001789 Common - translation initiation factor IF-2 Shew185_3280 249 COG0532 InfB, Translation initiation factor 2 (IF-2; GTPase) Translation, ribosomal structure and biogenesis 153002846 Common - hypothetical protein Shew185_4350 11 None None None 152998846 Common - peptidase M23B Shew185_0293 63 COG0739 NlpD, Membrane proteins related to metalloendopeptidases Cell envelope biogenesis, outer membrane 152999698 Common - peptidase C26 Shew185_1164 115 COG2071 COG2071, Predicted glutamine amidotransferases General function prediction only 153000577 Common - Lytic transglycosylase catalytic Shew185_2053 149 COG0741 MltE, Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) Cell envelope biogenesis, outer membrane 153000827 Common - aspartyl-tRNA synthetase Shew185_2307 249 COG0173 AspS, Aspartyl-tRNA synthetase Translation, ribosomal structure and biogenesis 153001925 Common - glutamate 5-kinase Shew185_3416 189 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 152998929 Common - ribosomal protein L33 Shew185_0378 140 COG0267 RpmG, Ribosomal protein L33 Translation, ribosomal structure and biogenesis 153000901 Common - ferredoxin, 2Fe-2S type, ISC system Shew185_2381 102 COG0633 Fdx, Ferredoxin Energy production and conversion 152999352 Common - Beta-lactamase Shew185_0813 38 COG2602 COG2602, Beta-lactamase class D Defense mechanisms 153001216 Common - hypothetical protein Shew185_2700 1 None None None 153000388 Nonpathogen - hypothetical protein Shew185_1863 1 None None None 153001808 Common - GTP-binding protein YchF Shew185_3299 249 COG0012 COG0012, Predicted GTPase, probable translation factor Translation, ribosomal structure and biogenesis 153002108 Common - protein of unknown function DUF520 Shew185_3601 107 COG1666 COG1666, Uncharacterized protein conserved in bacteria Function unknown 153000512 Common - peptidase S1 and S6 chymotrypsin/Hap Shew185_1987 2 None None None 153002631 Common - hypothetical protein Shew185_4132 19 None None None 152999210 Common - protein of unknown function DUF1568 Shew185_0670 17 None None None 153001023 Common - GreA/GreB family elongation factor Shew185_2504 67 COG0782 GreA, Transcription elongation factor Transcription 153002464 Common - fumarate reductase respiratory complex transmembrane subunit Shew185_3961 10 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 152999451 Nonpathogen - hypothetical protein Shew185_0915 2 None None None 153000561 Common - tryptophan halogenase Shew185_2037 16 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 153001510 Common - hypothetical protein Shew185_2997 5 None None None 153001701 Common - thioesterase superfamily protein Shew185_3189 74 COG0824 FcbC, Predicted thioesterase General function prediction only 152999165 Common - hypothetical protein Shew185_0622 94 COG1112 COG1112, Superfamily I DNA and RNA helicases and helicase subunits DNA replication, recombination, and repair 153002605 Common - molybdopterin oxidoreductase Shew185_4106 193 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 152999937 Common - transport-associated protein Shew185_1405 33 COG2823 OsmY, Predicted periplasmic or secreted lipoprotein General function prediction only 152998931 Common - hypothetical protein Shew185_0380 3 None None None 152999843 Common - hypothetical protein Shew185_1311 1 None None None 152999632 Common - glutamate--cysteine ligase Shew185_1098 58 COG2918 GshA, Gamma-glutamylcysteine synthetase Coenzyme metabolism 152998913 Common - transcriptional regulator, LysR family Shew185_0361 158 COG0583 LysR, Transcriptional regulator Transcription 153002272 Common - GTP-binding protein HSR1-related Shew185_3766 235 COG2262 HflX, GTPases General function prediction only 152999085 Common - methionine repressor, MetJ Shew185_0535 23 COG3060 MetJ, Transcriptional regulator of met regulon Transcription / Amino acid transport and metabolism 153002396 Common - periplasmic binding protein/LacI transcriptional regulator Shew185_3890 21 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 153001316 Common - YaeQ family protein Shew185_2800 52 COG4681 COG4681, Uncharacterized protein conserved in bacteria Function unknown 153001781 Common - hypothetical protein Shew185_3272 1 None None None 153000852 Common - hypothetical protein Shew185_2332 121 COG1092 COG1092, Predicted SAM-dependent methyltransferases General function prediction only 153000556 Common - ferredoxin-dependent glutamate synthase Shew185_2032 202 COG0069 GltB, Glutamate synthase domain 2 Amino acid transport and metabolism 152998648 Common - Siderophore-interacting protein Shew185_0094 63 COG2375 ViuB, Siderophore-interacting protein Inorganic ion transport and metabolism 152999136 Common - hypothetical protein Shew185_0592 2 None None None 153000106 Common - cytochrome C family protein Shew185_1577 38 None None None 153002776 Nonpathogen - protein of unknown function DUF1656 Shew185_4280 3 None None None 152999623 Common - hypothetical protein Shew185_1089 5 None None None 153001424 Common - hypothetical protein Shew185_2908 2 COG4372 COG4372, Uncharacterized protein conserved in bacteria with the myosin-like domain Function unknown 152999065 Common - protein of unknown function DUF331 Shew185_0515 20 COG3036 COG3036, Uncharacterized protein conserved in bacteria Function unknown 153002824 Common - UDP-glucose/GDP-mannose dehydrogenase Shew185_4328 207 COG1004 Ugd, Predicted UDP-glucose 6-dehydrogenase Cell envelope biogenesis, outer membrane 153002832 Common - glycosyl transferase family 9 Shew185_4336 97 COG0859 RfaF, ADP-heptose:LPS heptosyltransferase Cell envelope biogenesis, outer membrane 152999704 Common - FAD dependent oxidoreductase Shew185_1170 127 COG0665 DadA, Glycine/D-amino acid oxidases (deaminating) Amino acid transport and metabolism 153002471 Common - putative transcriptional regulator Shew185_3968 14 COG2865 COG2865, Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen Transcription 153002570 Common - protein of unknown function UPF0102 Shew185_4070 131 COG0792 COG0792, Predicted endonuclease distantly related to archaeal Holliday junction resolvase DNA replication, recombination, and repair 153001627 Common - protein of unknown function DUF486 Shew185_3114 53 COG3169 COG3169, Uncharacterized protein conserved in bacteria Function unknown 153001898 Common - ribose 5-phosphate isomerase Shew185_3389 165 COG0120 RpiA, Ribose 5-phosphate isomerase Carbohydrate transport and metabolism 153002769 Common - hypothetical protein Shew185_4272 7 None None None 153000888 Common - hypothetical protein Shew185_2368 1 None None None 153001470 Common - flagellar basal-body rod protein FlgG Shew185_2957 126 COG4786 FlgG, Flagellar basal body rod protein Cell motility and secretion 153002731 Common - TonB-dependent receptor Shew185_4233 127 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 152998756 Common - ribosomal protein L16 Shew185_0203 216 COG0197 RplP, Ribosomal protein L16/L10E Translation, ribosomal structure and biogenesis 153002747 Common - hypothetical protein Shew185_4249 1 None None None 153002401 Common - NUDIX hydrolase Shew185_3895 71 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 153002258 Common - aldehyde dehydrogenase Shew185_3752 220 COG1012 PutA, NAD-dependent aldehyde dehydrogenases Energy production and conversion 153002508 Common - Serine--pyruvate transaminase Shew185_4005 159 COG0075 COG0075, Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase Amino acid transport and metabolism 153002853 Common - hypothetical protein Shew185_4357 1 None None None 152999861 Common - extracellular solute-binding protein family 3 Shew185_1329 17 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 153000668 Common - alpha/beta hydrolase fold Shew185_2144 166 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152999806 Common - threonine synthase Shew185_1273 139 COG0498 ThrC, Threonine synthase Amino acid transport and metabolism 153001852 Common - transport system permease protein Shew185_3343 189 COG4606 CeuB, ABC-type enterochelin transport system, permease component Inorganic ion transport and metabolism 152998966 Common - twin-arginine translocation protein, TatB subunit Shew185_0415 23 COG1826 TatA, Sec-independent protein secretion pathway components Intracellular trafficking and secretion 153000921 Common - hypothetical protein Shew185_2402 13 None None None 153002725 Common - short-chain dehydrogenase/reductase SDR Shew185_4227 238 COG1028 FabG, Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only 152999532 Common - ABC transporter related Shew185_0998 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 152998982 Common - ATP-dependent protease La (LON) domain protein, putative Shew185_0432 16 COG2802 COG2802, Uncharacterized protein, similar to the N-terminal domain of Lon protease General function prediction only 153002042 Common - hypothetical protein Shew185_3533 1 None None None 152999177 Common - galactokinase Shew185_0634 88 COG0153 GalK, Galactokinase Carbohydrate transport and metabolism 153002670 Common - efflux transporter, RND family, MFP subunit Shew185_4172 155 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153000057 Common - Lysine exporter protein (LYSE/YGGA) Shew185_1527 102 COG1280 RhtB, Putative threonine efflux protein Amino acid transport and metabolism 152999191 Common - HipA domain protein Shew185_0650 60 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 152999940 Nonpathogen - hypothetical protein Shew185_1408 1 None None None 153002376 Common - periplasmic copper-binding Shew185_3870 47 COG3420 NosD, Nitrous oxidase accessory protein Inorganic ion transport and metabolism 152999528 Common - hypothetical protein Shew185_0994 1 None None None 152998996 Common - heat shock protein HslVU, ATPase subunit HslU Shew185_0446 210 COG1220 HslU, ATP-dependent protease HslVU (ClpYQ), ATPase subunit Posttranslational modification, protein turnover, chaperones 153001342 Common - TRAP dicarboxylate transporter, DctM subunit Shew185_2826 135 COG1593 DctQ, TRAP-type C4-dicarboxylate transport system, large permease component Carbohydrate transport and metabolism 153001399 Common - glucose-1-phosphate thymidylyltransferase Shew185_2883 185 COG1209 RfbA, dTDP-glucose pyrophosphorylase Cell envelope biogenesis, outer membrane 152999492 Common - peptidase S11 D-alanyl-D-alanine carboxypeptidase 1 Shew185_0957 155 COG1686 DacC, D-alanyl-D-alanine carboxypeptidase Cell envelope biogenesis, outer membrane 153002780 Common - glutamate 5-kinase Shew185_4284 189 COG0263 ProB, Glutamate 5-kinase Amino acid transport and metabolism 152999227 Common - Cell envelope biogenesis YhbN Shew185_0688 42 COG1934 COG1934, Uncharacterized protein conserved in bacteria Function unknown 153001411 Common - putative acetyltransferase Shew185_2895 155 COG0110 WbbJ, Acetyltransferase (isoleucine patch superfamily) General function prediction only 152999372 Common - response regulator receiver modulated metal dependent phosphohydrolase Shew185_0836 221 COG3437 COG3437, Response regulator containing a CheY-like receiver domain and an HD-GYP domain Transcription / Signal transduction mechanisms 153001358 Common - 6-phosphogluconate dehydrogenase, decarboxylating Shew185_2842 143 COG0362 Gnd, 6-phosphogluconate dehydrogenase Carbohydrate transport and metabolism 153002389 Nonpathogen - hypothetical protein Shew185_3883 1 None None None 153000221 Common - phage integrase family protein Shew185_1695 227 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 152999295 Common - peptidase S14 ClpP Shew185_0756 139 COG0740 ClpP, Protease subunit of ATP-dependent Clp proteases Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion 152999974 Common - 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase Shew185_1442 139 COG2171 DapD, Tetrahydrodipicolinate N-succinyltransferase Amino acid transport and metabolism 152998594 Common - transcriptional regulator, BadM/Rrf2 family Shew185_0039 136 COG1959 COG1959, Predicted transcriptional regulator Transcription 152999836 Common - diguanylate cyclase Shew185_1304 176 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152998953 Common - UDP-N-acetylmuramate--alanine ligase Shew185_0402 209 COG0773 MurC, UDP-N-acetylmuramate-alanine ligase Cell envelope biogenesis, outer membrane 153001410 Common - glycosyl transferase family 2 Shew185_2894 57 COG1216 COG1216, Predicted glycosyltransferases General function prediction only 153000378 Common - putative prophage repressor Shew185_1853 32 COG1974 LexA, SOS-response transcriptional repressors (RecA-mediated autopeptidases) Transcription / Signal transduction mechanisms 153001969 Common - Na+ antiporter NhaC Shew185_3460 72 COG1757 NhaC, Na+/H+ antiporter Energy production and conversion 153001871 Common - transcriptional regulator, XRE family Shew185_3362 2 COG1396 HipB, Predicted transcriptional regulators Transcription 153001660 Common - protein of unknown function DUF416 Shew185_3147 26 COG3068 COG3068, Uncharacterized protein conserved in bacteria Function unknown 152998661 Common - SirA family protein Shew185_0108 32 COG0425 SirA, Predicted redox protein, regulator of disulfide bond formation Posttranslational modification, protein turnover, chaperones 153002357 Common - hypothetical protein Shew185_3851 5 None None None 153001059 Common - transposase IS3/IS911 family protein Shew185_2540 147 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 153002149 Common - putative signal transduction protein Shew185_3642 1 COG1639 COG1639, Predicted signal transduction protein Signal transduction mechanisms 153002554 Common - amino acid permease-associated region Shew185_4054 172 COG0531 PotE, Amino acid transporters Amino acid transport and metabolism 153000305 Common - hypothetical protein Shew185_1780 5 None None None 153002017 Common - hypothetical protein Shew185_3508 12 None None None 153001349 Common - transcriptional regulator, LysR family Shew185_2833 193 COG0583 LysR, Transcriptional regulator Transcription 153000735 Common - outer membrane lipoprotein carrier protein LolA Shew185_2214 65 COG2834 LolA, Outer membrane lipoprotein-sorting protein Cell envelope biogenesis, outer membrane 153002189 Common - 5-formyltetrahydrofolate cyclo-ligase Shew185_3682 145 COG0212 COG0212, 5-formyltetrahydrofolate cyclo-ligase Coenzyme metabolism 152998659 Common - formate dehydrogenase family accessory protein FdhD Shew185_0106 136 COG1526 FdhD, Uncharacterized protein required for formate dehydrogenase activity Energy production and conversion 153001614 Common - hypothetical protein Shew185_3101 10 None None None 153002140 Common - protein of unknown function DUF1456 Shew185_3633 31 COG4807 COG4807, Uncharacterized protein conserved in bacteria Function unknown 152998978 Common - Inorganic diphosphatase Shew185_0428 54 COG1227 PPX1, Inorganic pyrophosphatase/exopolyphosphatase Energy production and conversion 153002787 Common - PepSY-associated TM helix domain protein Shew185_4291 33 COG3182 PiuB, Uncharacterized iron-regulated membrane protein Function unknown 152998615 Common - periplasmic binding protein/LacI transcriptional regulator Shew185_0060 124 COG1609 PurR, Transcriptional regulators Transcription 152999379 Common - hypothetical protein Shew185_0843 1 None None None 152999684 Common - protein of unknown function DUF861 cupin_3 Shew185_1150 33 COG3450 COG3450, Predicted enzyme of the cupin superfamily General function prediction only 153001012 Common - hypothetical protein Shew185_2493 3 None None None 153002592 Common - ornithine carbamoyltransferase Shew185_4093 240 COG0078 ArgF, Ornithine carbamoyltransferase Amino acid transport and metabolism 152999801 Common - Trp operon repressor Shew185_1268 22 COG2973 TrpR, Trp operon repressor Transcription 152999114 Common - transposase IS4 family protein Shew185_0564 33 COG5433 COG5433, Transposase DNA replication, recombination, and repair 153000165 Common - protein of unknown function DUF81 Shew185_1638 132 COG0730 COG0730, Predicted permeases General function prediction only 152998902 Common - putative endoribonuclease L-PSP Shew185_0350 183 COG0251 TdcF, Putative translation initiation inhibitor, yjgF family Translation, ribosomal structure and biogenesis 153000427 Common - integration host factor, alpha subunit Shew185_1902 208 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 153000508 Common - HipA domain protein Shew185_1983 73 COG3550 HipA, Uncharacterized protein related to capsule biosynthesis enzymes General function prediction only 153002762 Nonpathogen - hypothetical protein Shew185_4265 1 None None None 153002303 Common - ABC-3 protein Shew185_3797 9 COG1108 ZnuB, ABC-type Mn2+/Zn2+ transport systems, permease components Inorganic ion transport and metabolism 153000811 Common - Ribonucleoside-diphosphate reductase Shew185_2291 153 COG0208 NrdF, Ribonucleotide reductase, beta subunit Nucleotide transport and metabolism 153000962 Common - YebG family protein Shew185_2443 19 COG3141 COG3141, Uncharacterized protein conserved in bacteria Function unknown 153001547 Common - protein of unknown function DUF179 Shew185_3034 130 COG1678 COG1678, Putative transcriptional regulator Transcription 153000194 Common - DNA internalization-related competence protein ComEC/Rec2 Shew185_1667 143 COG2333 ComEC, Predicted hydrolase (metallo-beta-lactamase superfamily) General function prediction only 153001957 Common - putative transcriptional regulator, GntR family Shew185_3448 224 COG1167 ARO8, Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs Transcription / Amino acid transport and metabolism 153001751 Nonpathogen - hypothetical protein Shew185_3242 3 None None None 152998758 Common - ribosomal protein S17 Shew185_0205 238 COG0186 RpsQ, Ribosomal protein S17 Translation, ribosomal structure and biogenesis 153001303 Common - hypothetical protein Shew185_2787 27 None None None 152998728 Common - transcriptional regulator, TetR family Shew185_0175 54 COG1309 AcrR, Transcriptional regulator Transcription 153001293 Common - hypothetical protein Shew185_2777 1 None None None 152999999 Common - PHP domain protein Shew185_1467 58 COG1387 HIS2, Histidinol phosphatase and related hydrolases of the PHP family Amino acid transport and metabolism / General function prediction only 153000840 Common - thiamine biosynthesis protein ThiS Shew185_2320 4 COG2104 ThiS, Sulfur transfer protein involved in thiamine biosynthesis Coenzyme metabolism 152998731 Common - RNP-1 like RNA-binding protein Shew185_0178 66 COG0724 COG0724, RNA-binding proteins (RRM domain) General function prediction only 153000835 Common - transcriptional regulator, LysR family Shew185_2315 157 COG0583 LysR, Transcriptional regulator Transcription 153002746 Common - hypothetical protein Shew185_4248 1 None None None 152998887 Common - glycosyl transferase family 2 Shew185_0335 141 COG4261 COG4261, Predicted acyltransferase General function prediction only 153000525 Common - C4-dicarboxylate anaerobic carrier Shew185_2000 40 COG1288 COG1288, Predicted membrane protein Function unknown 153001869 Common - integron integrase Shew185_3360 223 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 153001950 Common - TRAP dicarboxylate transporter- DctP subunit Shew185_3441 112 COG4663 FcbT1, TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component Secondary metabolites biosynthesis, transport, and catabolism 152999234 Common - toluene tolerance family protein Shew185_0695 70 COG2854 Ttg2D, ABC-type transport system involved in resistance to organic solvents, auxiliary component Secondary metabolites biosynthesis, transport, and catabolism 152999170 Common - efflux transporter, RND family, MFP subunit Shew185_0627 172 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 152998682 Common - response regulator receiver protein Shew185_0129 2 COG0670 COG0670, Integral membrane protein, interacts with FtsH General function prediction only 153000040 Common - hypothetical protein Shew185_1510 2 None None None 152999026 Common - hypothetical protein Shew185_0476 3 COG3170 FimV, Tfp pilus assembly protein FimV Cell motility and secretion / Intracellular trafficking and secretion 153002525 Common - 2-methylisocitrate dehydratase, Fe/S-dependent Shew185_4023 223 COG1048 AcnA, Aconitase A Energy production and conversion 152999312 Common - phage integrase family protein Shew185_0773 62 COG4974 XerD, Site-specific recombinase XerD DNA replication, recombination, and repair 153000329 Common - GCN5-related N-acetyltransferase Shew185_1804 43 COG0456 RimI, Acetyltransferases General function prediction only 153000789 Common - Domain of unknown function DUF1904 Shew185_2269 8 None None None 152999607 Common - MltA-interacting MipA family protein Shew185_1073 22 COG3713 OmpV, Outer membrane protein V Cell envelope biogenesis, outer membrane 153001245 Common - hypothetical protein Shew185_2729 15 None None None 153001857 Common - transcriptional regulator, LysR family Shew185_3348 163 COG0583 LysR, Transcriptional regulator Transcription 153000866 Common - hypothetical protein Shew185_2346 10 None None None 153002216 Common - isochorismatase hydrolase Shew185_3709 89 COG1335 PncA, Amidases related to nicotinamidase Secondary metabolites biosynthesis, transport, and catabolism 153000649 Common - Peptidyl-dipeptidase A Shew185_2125 16 COG1164 COG1164, Oligoendopeptidase F Amino acid transport and metabolism 152999434 Common - AFG1-family ATPase Shew185_0898 93 COG1485 COG1485, Predicted ATPase General function prediction only 152999539 Common - Curli production assembly/transport component CsgG Shew185_1005 16 COG1462 CsgG, Uncharacterized protein involved in formation of curli polymers Cell envelope biogenesis, outer membrane 153001469 Common - flagellar L-ring protein Shew185_2956 101 COG2063 FlgH, Flagellar basal body L-ring protein Cell motility and secretion 153002688 Common - polysaccharide deacetylase Shew185_4190 102 COG0726 CDA1, Predicted xylanase/chitin deacetylase Carbohydrate transport and metabolism 153001653 Common - Amidase Shew185_3140 219 COG0154 GatA, Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases Translation, ribosomal structure and biogenesis 153001681 Common - efflux transporter, RND family, MFP subunit Shew185_3169 170 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 153002711 Common - integral membrane sensor signal transduction histidine kinase Shew185_4213 215 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152999361 Common - NapD family protein Shew185_0825 28 COG3062 NapD, Uncharacterized protein involved in formation of periplasmic nitrate reductase Inorganic ion transport and metabolism 153001120 Common - transposase Shew185_2603 9 None None None 153001324 Common - S-adenosylmethionine--tRNA-ribosyltransferase-isomerase Shew185_2808 183 COG0809 QueA, S-adenosylmethionine:tRNA-ribosyltransferase-isomerase (queuine synthetase) Translation, ribosomal structure and biogenesis 153000589 Common - electron transport complex, RnfABCDGE type, A subunit Shew185_2065 76 COG4657 RnfA, Predicted NADH:ubiquinone oxidoreductase, subunit RnfA Energy production and conversion 153001962 Common - helix-turn-helix- domain containing protein AraC type Shew185_3453 64 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 153000428 Common - lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase Shew185_1903 89 COG1560 HtrB, Lauroyl/myristoyl acyltransferase Cell envelope biogenesis, outer membrane 153001662 Common - transcriptional regulator, LysR family Shew185_3149 178 COG0583 LysR, Transcriptional regulator Transcription 153000616 Common - hypothetical protein Shew185_2092 1 None None None 153000093 Common - hypothetical protein Shew185_1564 1 None None None 153000782 Common - hypothetical protein Shew185_2262 1 None None None 153000315 Common - histidine triad (HIT) protein Shew185_1790 214 COG0537 Hit, Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only 153001939 Common - bacterioferritin Shew185_3430 98 COG2193 Bfr, Bacterioferritin (cytochrome b1) Inorganic ion transport and metabolism 153002737 Nonpathogen - Biopolymer transport protein ExbD/TolR Shew185_4239 3 COG0848 ExbD, Biopolymer transport protein Intracellular trafficking and secretion 152999726 Common - protein of unknown function DUF205 Shew185_1193 165 COG0344 COG0344, Predicted membrane protein Function unknown 152999344 Common - protein of unknown function DUF342 Shew185_0805 37 COG1315 COG1315, Predicted polymerase, most proteins contain PALM domain, HD hydrolase domain and Zn-ribbon domain DNA replication, recombination, and repair 153001332 Common - putative CheW protein Shew185_2816 161 COG0835 CheW, Chemotaxis signal transduction protein Cell motility and secretion / Signal transduction mechanisms 153001254 Common - hypothetical protein Shew185_2738 16 None None None 153000467 Common - NUDIX hydrolase Shew185_1942 120 COG0494 MutT, NTP pyrophosphohydrolases including oxidative damage repair enzymes DNA replication, recombination, and repair / General function prediction only 152999852 Common - 4-alpha-glucanotransferase Shew185_1320 117 COG1640 MalQ, 4-alpha-glucanotransferase Carbohydrate transport and metabolism 153001395 Common - protein of unknown function DUF1017 Shew185_2879 15 None None None 153001975 Common - chitin-binding domain 3 protein Shew185_3466 30 COG3397 COG3397, Uncharacterized protein conserved in bacteria Function unknown 153000052 Common - hypothetical protein Shew185_1522 4 None None None 153000303 Common - hypothetical protein Shew185_1778 19 COG3249 COG3249, Uncharacterized protein conserved in bacteria Function unknown 153001695 Common - transcriptional regulator, LysR family Shew185_3183 171 COG0583 LysR, Transcriptional regulator Transcription 152999744 Common - MIP family channel protein Shew185_1211 125 COG0580 GlpF, Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) Carbohydrate transport and metabolism 153002485 Common - putative outer membrane adhesin like proteiin Shew185_3982 200 None None None 153000238 Common - fatty acid/phospholipid synthesis protein PlsX Shew185_1713 177 COG0416 PlsX, Fatty acid/phospholipid biosynthesis enzyme Lipid metabolism 153000761 Common - response regulator receiver modulated diguanylate cyclase Shew185_2241 218 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152998941 Common - glycerol kinase Shew185_0390 179 COG0554 GlpK, Glycerol kinase Energy production and conversion 153002078 Common - hypothetical protein Shew185_3570 4 None None None 153002050 Common - Methionine adenosyltransferase Shew185_3541 213 COG0192 MetK, S-adenosylmethionine synthetase Coenzyme metabolism 153001436 Common - Cobyrinic acid ac-diamide synthase Shew185_2920 163 COG0455 COG0455, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 153002628 Common - peptidase M16 domain protein Shew185_4129 171 COG0612 PqqL, Predicted Zn-dependent peptidases General function prediction only 153000599 Common - hypothetical protein Shew185_2075 1 None None None 152998600 Common - protein-export protein SecB Shew185_0045 108 COG1952 SecB, Preprotein translocase subunit SecB Intracellular trafficking and secretion 153000100 Common - Gluconate transporter Shew185_1571 80 COG2610 GntT, H+/gluconate symporter and related permeases Carbohydrate transport and metabolism / Amino acid transport and metabolism 152999373 Common - glycine cleavage T protein (aminomethyl transferase) Shew185_0837 113 COG0354 COG0354, Predicted aminomethyltransferase related to GcvT General function prediction only 153001274 Common - FolC bifunctional protein Shew185_2758 217 COG0285 FolC, Folylpolyglutamate synthase Coenzyme metabolism 152999927 Common - thioesterase superfamily protein Shew185_1395 12 COG2050 PaaI, Uncharacterized protein, possibly involved in aromatic compounds catabolism Secondary metabolites biosynthesis, transport, and catabolism 153001509 Common - CMP/dCMP deaminase zinc-binding Shew185_2996 218 COG0590 CumB, Cytosine/adenosine deaminases Nucleotide transport and metabolism / Translation, ribosomal structure and biogenesis 152999475 Common - Protoporphyrinogen oxidase Shew185_0939 35 COG4635 HemG, Flavodoxin Energy production and conversion / Coenzyme metabolism 153002421 Common - transposase IS4 family protein Shew185_3915 26 COG3385 COG3385, FOG: Transposase and inactivated derivatives DNA replication, recombination, and repair 153000784 Common - protein of unknown function DUF839 Shew185_2264 65 COG3211 PhoX, Predicted phosphatase General function prediction only 152999609 Common - GPR1/FUN34/yaaH family protein Shew185_1075 50 COG1584 COG1584, Predicted membrane protein Function unknown 153000438 Common - Ni/Fe-hydrogenase, b-type cytochrome subunit Shew185_1913 51 COG1969 HyaC, Ni,Fe-hydrogenase I cytochrome b subunit Energy production and conversion 152999422 Common - hypothetical protein Shew185_0886 6 None None None 153002137 Common - TonB-dependent receptor Shew185_3630 107 COG4771 FepA, Outer membrane receptor for ferrienterochelin and colicins Inorganic ion transport and metabolism 153002535 Common - DSBA oxidoreductase Shew185_4035 67 COG1651 DsbG, Protein-disulfide isomerase Posttranslational modification, protein turnover, chaperones 153001067 Common - molydopterin dinucleotide-binding region Shew185_2549 183 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 152999516 Common - cob(I)alamin adenosyltransferase Shew185_0981 142 COG2109 BtuR, ATP:corrinoid adenosyltransferase Coenzyme metabolism 153000114 Common - glutaminyl-tRNA synthetase Shew185_1585 244 COG0008 GlnS, Glutamyl- and glutaminyl-tRNA synthetases Translation, ribosomal structure and biogenesis 153000431 Common - hydrogenase expression/formation protein HypD Shew185_1906 109 COG0409 HypD, Hydrogenase maturation factor Posttranslational modification, protein turnover, chaperones 153002138 Common - membrane-flanked domain Shew185_3631 12 COG3428 COG3428, Predicted membrane protein Function unknown 153002267 Common - cytochrome c1 Shew185_3761 83 COG2857 CYT1, Cytochrome c1 Energy production and conversion 153001136 Common - hypothetical protein Shew185_2619 17 COG3219 COG3219, Uncharacterized protein conserved in bacteria Function unknown 153002450 Common - protein of unknown function DUF329 Shew185_3947 59 COG3024 COG3024, Uncharacterized protein conserved in bacteria Function unknown 153001994 Common - helix-turn-helix- domain containing protein AraC type Shew185_3485 87 COG2207 AraC, AraC-type DNA-binding domain-containing proteins Transcription 152998559 Common - DNA gyrase, B subunit Shew185_0004 230 COG0187 GyrB, Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit DNA replication, recombination, and repair 152998985 Common - hypothetical protein Shew185_0435 22 COG3540 PhoD, Phosphodiesterase/alkaline phosphatase D Inorganic ion transport and metabolism 152999151 Common - ABC transporter related Shew185_0608 249 COG1136 SalX, ABC-type antimicrobial peptide transport system, ATPase component Defense mechanisms 153000067 Nonpathogen - hypothetical protein Shew185_1537 1 None None None 152998859 Common - glutamine synthetase, type I Shew185_0307 227 COG0174 GlnA, Glutamine synthetase Amino acid transport and metabolism 153000614 Common - phage putative head morphogenesis protein, SPP1 gp7 family Shew185_2090 28 COG2369 COG2369, Uncharacterized protein, homolog of phage Mu protein gp30 Function unknown 153000954 Common - BNR repeat protein Shew185_2435 32 COG4447 COG4447, Uncharacterized protein related to plant photosystem II stability/assembly factor General function prediction only 153001576 Common - Cyclopropane-fatty-acyl-phospholipid synthase Shew185_3063 129 COG2230 Cfa, Cyclopropane fatty acid synthase and related methyltransferases Cell envelope biogenesis, outer membrane 153002828 Common - glycosyl transferase group 1 Shew185_4332 132 COG0438 RfaG, Glycosyltransferase Cell envelope biogenesis, outer membrane 152999159 Common - fumarate reductase respiratory complex transmembrane subunit Shew185_0616 11 COG2009 SdhC, Succinate dehydrogenase/fumarate reductase, cytochrome b subunit Energy production and conversion 153001220 Common - domain of unknown function DUF1731 Shew185_2704 109 COG1090 COG1090, Predicted nucleoside-diphosphate sugar epimerase General function prediction only 152998761 Common - ribosomal protein L5 Shew185_0208 249 COG0094 RplE, Ribosomal protein L5 Translation, ribosomal structure and biogenesis 153001468 Common - flagellar P-ring protein Shew185_2955 105 COG1706 FlgI, Flagellar basal-body P-ring protein Cell motility and secretion 153001669 Common - 3,4-dihydroxy-2-butanone 4-phosphate synthase Shew185_3156 230 COG0108 RibB, 3,4-dihydroxy-2-butanone 4-phosphate synthase Coenzyme metabolism 153001193 Common - NAD-dependent epimerase/dehydratase Shew185_2676 67 COG0451 WcaG, Nucleoside-diphosphate-sugar epimerases Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism 153001406 Common - mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase Shew185_2890 165 COG0836 {ManC}, Mannose-1-phosphate guanylyltransferase Cell envelope biogenesis, outer membrane 152998823 Common - hypothetical protein Shew185_0270 1 None None None 152999399 Common - ABC transporter related Shew185_0863 249 COG0488 Uup, ATPase components of ABC transporters with duplicated ATPase domains General function prediction only 153000036 Common - diguanylate cyclase with PAS/PAC sensor Shew185_1504 178 COG3706 PleD, Response regulator containing a CheY-like receiver domain and a GGDEF domain Signal transduction mechanisms 152999653 Common - integral membrane protein MviN Shew185_1119 194 COG0728 MviN, Uncharacterized membrane protein, putative virulence factor General function prediction only 152998799 Common - transcriptional regulator, LysR family Shew185_0246 130 COG0583 LysR, Transcriptional regulator Transcription 153001075 Common - putative replication protein Shew185_2558 18 None None None 153000870 Common - phosphoenolpyruvate-protein phosphotransferase Shew185_2350 235 COG1080 PtsA, Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) Carbohydrate transport and metabolism 153001113 Common - Dipeptidase E Shew185_2596 33 COG3340 PepE, Peptidase E Amino acid transport and metabolism 153000390 Nonpathogen - hypothetical protein Shew185_1865 1 None None None 153001779 Common - hypothetical protein Shew185_3270 4 None None None 153001139 Common - dihydrouridine synthase DuS Shew185_2622 208 COG0042 COG0042, tRNA-dihydrouridine synthase Translation, ribosomal structure and biogenesis 153001029 Common - succinate dehydrogenase, flavoprotein subunit Shew185_2510 226 COG1053 SdhA, Succinate dehydrogenase/fumarate reductase, flavoprotein subunit Energy production and conversion 153001261 Common - protein of unknown function DUF1097 Shew185_2745 14 None None None 153001500 Common - efflux transporter, RND family, MFP subunit Shew185_2987 154 COG0845 AcrA, Membrane-fusion protein Cell envelope biogenesis, outer membrane 152999367 Common - hypothetical protein Shew185_0831 50 COG5621 COG5621, Predicted secreted hydrolase General function prediction only 153002342 Common - transcriptional regulator, AraC family Shew185_3836 133 COG4977 COG4977, Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain Transcription 153002583 Common - Shikimate kinase Shew185_4084 201 COG0703 AroK, Shikimate kinase Amino acid transport and metabolism 153002414 Common - major facilitator superfamily MFS_1 Shew185_3908 55 COG0738 FucP, Fucose permease Carbohydrate transport and metabolism 153001999 Common - carbon starvation protein CstA Shew185_3490 109 COG1966 CstA, Carbon starvation protein, predicted membrane protein Signal transduction mechanisms 152999360 Common - periplasmic nitrate reductase, large subunit Shew185_0824 182 COG0243 BisC, Anaerobic dehydrogenases, typically selenocysteine-containing Energy production and conversion 153001551 Common - twitching motility protein Shew185_3038 222 COG5008 PilU, Tfp pilus assembly protein, ATPase PilU Cell motility and secretion / Intracellular trafficking and secretion 153001047 Common - protein of unknown function DUF1414 Shew185_2528 21 COG3082 COG3082, Uncharacterized protein conserved in bacteria Function unknown 153001864 Common - hypothetical protein Shew185_3355 3 None None None 153002326 Common - response regulator receiver modulated diguanylate cyclase/phosphodiesterase Shew185_3820 197 COG5001 COG5001, Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain Signal transduction mechanisms 153000399 Nonpathogen - hypothetical protein Shew185_1874 1 None None None 152999992 Common - DNA polymerase III, alpha subunit Shew185_1460 216 COG0587 DnaE, DNA polymerase III, alpha subunit DNA replication, recombination, and repair 152998804 Common - Ankyrin Shew185_0251 56 COG0666 Arp, FOG: Ankyrin repeat General function prediction only 152998949 Common - phospho-N-acetylmuramoyl-pentapeptide-transferase Shew185_0398 225 COG0472 Rfe, UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase Cell envelope biogenesis, outer membrane 152998988 Common - two component transcriptional regulator, Fis family Shew185_0438 217 COG4567 COG4567, Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain Signal transduction mechanisms / Transcription 153002439 Common - regulatory protein GntR HTH Shew185_3935 148 COG2186 FadR, Transcriptional regulators Transcription 153001022 Common - GCN5-related N-acetyltransferase Shew185_2503 94 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 153001127 Common - putative RNA methylase Shew185_2610 169 COG0116 COG0116, Predicted N6-adenine-specific DNA methylase DNA replication, recombination, and repair 153000688 Common - cytochrome oxidase maturation protein, cbb3-type Shew185_2164 19 COG3197 FixS, Uncharacterized protein, possibly involved in nitrogen fixation Inorganic ion transport and metabolism 153002434 Common - Patatin Shew185_3929 123 COG1752 RssA, Predicted esterase of the alpha-beta hydrolase superfamily General function prediction only 152999271 Common - hypothetical protein Shew185_0732 1 None None None 152999491 Common - GCN5-related N-acetyltransferase Shew185_0956 33 COG1670 RimL, Acetyltransferases, including N-acetylases of ribosomal proteins Translation, ribosomal structure and biogenesis 153000005 Common - decaheme cytochrome c Shew185_1473 9 None None None 152998700 Common - RNA-binding S4 domain protein Shew185_0147 89 COG1188 COG1188, Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) Translation, ribosomal structure and biogenesis 153002098 Common - 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Shew185_3591 152 COG0163 UbiX, 3-polyprenyl-4-hydroxybenzoate decarboxylase Coenzyme metabolism 153002256 Common - integral membrane sensor signal transduction histidine kinase Shew185_3750 213 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 152998886 Common - Histidine ammonia-lyase Shew185_0334 110 COG2986 HutH, Histidine ammonia-lyase Amino acid transport and metabolism 152999032 Common - MSHA biogenesis protein MshJ Shew185_0482 15 None None None 153000986 Common - putative cold-shock DNA-binding domain protein Shew185_2467 178 COG1278 CspC, Cold shock proteins Transcription 153002498 Common - hypothetical protein Shew185_3995 1 None None None 152999716 Common - sugar (Glycoside-Pentoside-Hexuronide) transporter Shew185_1182 83 COG2211 MelB, Na+/melibiose symporter and related transporters Carbohydrate transport and metabolism 153000243 Common - Beta-ketoacyl synthase Shew185_1718 210 COG0304 FabB, 3-oxoacyl-(acyl-carrier-protein) synthase Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism 153001827 Common - rod shape-determining protein RodA Shew185_3318 207 COG0772 FtsW, Bacterial cell division membrane protein Cell division and chromosome partitioning 153000415 Common - alpha/beta hydrolase fold Shew185_1890 69 COG0596 MhpC, Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) General function prediction only 152999584 Common - aminoglycoside phosphotransferase Shew185_1050 91 COG3178 COG3178, Predicted phosphotransferase related to Ser/Thr protein kinases General function prediction only 152999425 Common - hypothetical protein Shew185_0889 6 COG3789 COG3789, Uncharacterized protein conserved in bacteria Function unknown 153002600 Common - hypothetical protein Shew185_4101 5 None None None 153000293 Common - multi-sensor signal transduction histidine kinase Shew185_1768 42 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153000655 Common - 6-phosphogluconolactonase Shew185_2131 119 COG0363 NagB, 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase Carbohydrate transport and metabolism 153001453 Common - flagellar hook-basal body complex subunit FliE Shew185_2937 74 COG1677 FliE, Flagellar hook-basal body protein Cell motility and secretion / Intracellular trafficking and secretion 153002015 Common - D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding Shew185_3506 230 COG1052 LdhA, Lactate dehydrogenase and related dehydrogenases Energy production and conversion / Coenzyme metabolism / General function prediction only 152999550 Common - transport system permease protein Shew185_1016 190 COG0609 FepD, ABC-type Fe3+-siderophore transport system, permease component Inorganic ion transport and metabolism 152999304 Common - phage tape measure protein Shew185_0765 41 COG3941 COG3941, Mu-like prophage protein General function prediction only 153000014 Common - fumarylacetoacetate (FAA) hydrolase Shew185_1482 52 COG0179 MhpD, 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) Secondary metabolites biosynthesis, transport, and catabolism 153000335 Common - hypothetical protein Shew185_1810 18 COG4929 COG4929, Uncharacterized membrane-anchored protein Function unknown 153000741 Common - ribosomal protein L35 Shew185_2220 143 COG0291 RpmI, Ribosomal protein L35 Translation, ribosomal structure and biogenesis 153002339 Common - arsenical-resistance protein Shew185_3833 128 COG0798 ACR3, Arsenite efflux pump ACR3 and related permeases Inorganic ion transport and metabolism 153001499 Common - transcriptional regulator, TetR family Shew185_2986 116 COG1309 AcrR, Transcriptional regulator Transcription 153002870 Common - Cobyrinic acid ac-diamide synthase Shew185_4374 227 COG1192 Soj, ATPases involved in chromosome partitioning Cell division and chromosome partitioning 153002073 Common - aldo/keto reductase Shew185_3565 199 COG0667 Tas, Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) Energy production and conversion 153000938 Common - Histidinol dehydrogenase Shew185_2419 214 COG0141 HisD, Histidinol dehydrogenase Amino acid transport and metabolism 152998882 Common - monooxygenase FAD-binding Shew185_0330 51 COG0644 FixC, Dehydrogenases (flavoproteins) Energy production and conversion 152998657 Common - L-seryl-tRNA(Sec) selenium transferase Shew185_0104 70 COG1921 SelA, Selenocysteine synthase [seryl-tRNASer selenium transferase] Amino acid transport and metabolism 152999557 Common - pyridoxamine 5'-phosphate oxidase-related FMN-binding Shew185_1023 23 COG0748 HugZ, Putative heme iron utilization protein Inorganic ion transport and metabolism 152999788 Common - 16S rRNA processing protein RimM Shew185_1255 168 COG0806 RimM, RimM protein, required for 16S rRNA processing Translation, ribosomal structure and biogenesis 152999318 Common - hypothetical protein Shew185_0779 22 COG5345 COG5345, Uncharacterized protein conserved in bacteria Function unknown 152999013 Common - MscS Mechanosensitive ion channel Shew185_0463 145 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 153000603 Nonpathogen - hypothetical protein Shew185_2079 1 None None None 152998848 Common - Zn-dependent hydrolase of the beta-lactamase fold Shew185_0295 81 COG2220 COG2220, Predicted Zn-dependent hydrolases of the beta-lactamase fold General function prediction only 152998841 Common - pseudouridine synthase Rlu family protein, TIGR01621 Shew185_0288 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 153001387 Common - protein of unknown function UPF0066 Shew185_2871 92 COG1720 COG1720, Uncharacterized conserved protein Function unknown 152999466 Common - TrkA-C domain protein Shew185_0930 95 COG0471 CitT, Di- and tricarboxylate transporters Inorganic ion transport and metabolism 153001106 Common - NlpBDapX family lipoprotein Shew185_2589 41 COG3317 NlpB, Uncharacterized lipoprotein Cell envelope biogenesis, outer membrane 153002375 Common - ABC transporter related Shew185_3869 249 COG1131 CcmA, ABC-type multidrug transport system, ATPase component Defense mechanisms 153001339 Common - hypothetical protein Shew185_2823 2 None None None 153001822 Common - DNA polymerase III, delta subunit Shew185_3313 67 COG1466 HolA, DNA polymerase III, delta subunit DNA replication, recombination, and repair 153002248 Common - penicillin-binding protein 1B Shew185_3742 200 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 153000600 Common - protein of unknown function DUF1018 Shew185_2076 16 COG4382 COG4382, Mu-like prophage protein gp16 Function unknown 152998583 Common - Peptidoglycan-binding LysM Shew185_0028 47 COG1652 XkdP, Uncharacterized protein containing LysM domain Function unknown 153000979 Common - protein of unknown function DUF34 Shew185_2460 107 COG0327 COG0327, Uncharacterized conserved protein Function unknown 152999592 Common - pseudouridine synthase Shew185_1058 215 COG0564 RluA, Pseudouridylate synthases, 23S RNA-specific Translation, ribosomal structure and biogenesis 153001632 Common - Leucyl aminopeptidase Shew185_3119 188 COG0260 PepB, Leucyl aminopeptidase Amino acid transport and metabolism 152999859 Common - DEAD/DEAH box helicase domain protein Shew185_1327 235 COG0513 SrmB, Superfamily II DNA and RNA helicases DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis 153002223 Common - aspartate kinase Shew185_3717 234 COG0527 LysC, Aspartokinases Amino acid transport and metabolism 153000932 Common - helicase c2 Shew185_2413 142 COG1199 DinG, Rad3-related DNA helicases Transcription / DNA replication, recombination, and repair 153000304 Common - Chromosomal replication initiator DnaA Shew185_1779 185 COG0593 DnaA, ATPase involved in DNA replication initiation DNA replication, recombination, and repair 153000275 Common - adenosylmethionine-8-amino-7-oxononanoate aminotransferase Shew185_1750 237 COG0161 BioA, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Coenzyme metabolism 153002007 Common - transcriptional regulator, MarR family Shew185_3498 117 COG1846 MarR, Transcriptional regulators Transcription 153001679 Common - metallophosphoesterase Shew185_3167 9 None None None 152999711 Common - transcription factor jumonji jmjC domain protein Shew185_1177 20 COG2850 COG2850, Uncharacterized conserved protein Function unknown 153000829 Common - putative methyltransferase Shew185_2309 50 COG2226 UbiE, Methylase involved in ubiquinone/menaquinone biosynthesis Coenzyme metabolism 153002029 Common - hypothetical protein Shew185_3520 13 None None None 153002297 Common - hypothetical protein Shew185_3791 5 None None None 153002186 Common - 2-polyprenyl-6-methoxyphenol 4-hydroxylase Shew185_3679 115 COG0654 UbiH, 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases Coenzyme metabolism / Energy production and conversion 152999667 Common - nitrogen regulatory protein P-II Shew185_1133 188 COG0347 GlnK, Nitrogen regulatory protein PII Amino acid transport and metabolism 152998795 Common - Domain of unknown function DUF1924 Shew185_0242 13 None None None 153002517 Common - periplasmic sugar-binding protein, putative Shew185_4015 30 COG1879 RbsB, ABC-type sugar transport system, periplasmic component Carbohydrate transport and metabolism 153000443 Common - hypothetical protein Shew185_1918 14 None None None 153002284 Common - MscS Mechanosensitive ion channel Shew185_3778 217 COG3264 COG3264, Small-conductance mechanosensitive channel Cell envelope biogenesis, outer membrane 153000484 Common - hypothetical protein Shew185_1959 1 None None None 153001482 Common - hypothetical protein Shew185_2969 9 None None None 153000087 Common - Helix-turn-helix type 11 domain protein Shew185_1558 100 COG2378 COG2378, Predicted transcriptional regulator Transcription 153002313 Common - Methyltransferase type 11 Shew185_3807 68 COG2227 UbiG, 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase Coenzyme metabolism 153002877 Common - ribonuclease P protein component Shew185_4381 75 COG0594 RnpA, RNase P protein component Translation, ribosomal structure and biogenesis 153002540 Common - hypothetical protein Shew185_4040 1 None None None 152999282 Common - putative replication protein Shew185_0743 14 None None None 153002668 Common - hypothetical protein Shew185_4170 1 None None None 152999062 Common - peptidase U62 modulator of DNA gyrase Shew185_0512 157 COG0312 TldD, Predicted Zn-dependent proteases and their inactivated homologs General function prediction only 153000126 Common - PpiC-type peptidyl-prolyl cis-trans isomerase Shew185_1597 163 COG0760 SurA, Parvulin-like peptidyl-prolyl isomerase Posttranslational modification, protein turnover, chaperones 153002103 Common - OmpA domain protein transmembrane region-containing protein Shew185_3596 4 COG3637 COG3637, Opacity protein and related surface antigens Cell envelope biogenesis, outer membrane 152999675 Common - hypothetical protein Shew185_1141 15 COG0834 HisJ, ABC-type amino acid transport/signal transduction systems, periplasmic component/domain Amino acid transport and metabolism / Signal transduction mechanisms 152999382 Common - 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Shew185_0846 200 COG0801 FolK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Coenzyme metabolism 152999268 Common - hypothetical protein Shew185_0729 4 None None None 153001376 Common - hypothetical protein Shew185_2860 15 COG0744 MrcB, Membrane carboxypeptidase (penicillin-binding protein) Cell envelope biogenesis, outer membrane 153001545 Common - hypothetical protein Shew185_3032 1 None None None 153001881 Common - hypothetical protein Shew185_3372 19 None None None 153002055 Common - putative diguanylate cyclase Shew185_3546 5 COG2199 COG2199, FOG: GGDEF domain Signal transduction mechanisms 152998911 Common - filamentation induced by cAMP protein Fic Shew185_0359 91 COG3177 COG3177, Uncharacterized conserved protein Function unknown 153001744 Common - peptide chain release factor 3 Shew185_3235 249 COG4108 PrfC, Peptide chain release factor RF-3 Translation, ribosomal structure and biogenesis 153000287 Common - Adenosylmethionine decarboxylase Shew185_1762 2 None None None 153002331 Common - protein of unknown function DUF1704 Shew185_3825 16 COG3930 COG3930, Uncharacterized protein conserved in bacteria Function unknown 153001195 Common - hypothetical protein Shew185_2678 5 None None None 152999255 Common - replicative DNA helicase Shew185_0716 216 COG0305 DnaB, Replicative DNA helicase DNA replication, recombination, and repair 153002060 Common - GCN5-related N-acetyltransferase Shew185_3551 21 COG0456 RimI, Acetyltransferases General function prediction only 152999311 Common - hypothetical protein Shew185_0772 2 None None None 152999751 Common - hypothetical protein Shew185_1218 20 None None None 152998645 Common - FMN-binding negative transcriptional regulator Shew185_0091 61 COG2808 PaiB, Transcriptional regulator Transcription 153000592 Common - Integrase catalytic region Shew185_2068 34 None None None 153001267 Common - beta-lactamase domain protein Shew185_2751 217 COG0491 GloB, Zn-dependent hydrolases, including glyoxylases General function prediction only 153000353 Common - OmpA/MotB domain protein Shew185_1828 128 COG2885 OmpA, Outer membrane protein and related peptidoglycan-associated (lipo)proteins Cell envelope biogenesis, outer membrane 153001093 Common - hypothetical protein Shew185_2576 3 None None None 153002166 Nonpathogen - hypothetical protein Shew185_3659 1 None None None 153001056 Common - hypothetical protein Shew185_2537 20 None None None 153000330 Common - hypothetical protein Shew185_1805 1 None None None 153002698 Common - hypothetical protein Shew185_4200 1 None None None 153000457 Common - putative signal transduction protein with CBS domains Shew185_1932 53 COG2524 COG2524, Predicted transcriptional regulator, contains C-terminal CBS domains Transcription 153001142 Common - 5'-Nucleotidase domain protein Shew185_2625 128 COG0737 UshA, 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases Nucleotide transport and metabolism 152999781 Common - pyridoxal phosphate biosynthetic protein PdxJ Shew185_1248 139 COG0854 PdxJ, Pyridoxal phosphate biosynthesis protein Coenzyme metabolism 153001628 Common - hypothetical protein Shew185_3115 6 None None None 153002083 Common - cysteine desulfurase, SufS subfamily Shew185_3575 239 COG0520 CsdB, Selenocysteine lyase Amino acid transport and metabolism 152999245 Common - Sel1 domain protein repeat-containing protein Shew185_0706 36 COG0790 COG0790, FOG: TPR repeat, SEL1 subfamily General function prediction only 153000157 Common - TPR repeat-containing protein Shew185_1630 38 COG4783 COG4783, Putative Zn-dependent protease, contains TPR repeats General function prediction only 153002197 Common - gamma-glutamyltransferase Shew185_3690 148 COG0405 Ggt, Gamma-glutamyltransferase Amino acid transport and metabolism 153001489 Common - hypothetical protein Shew185_2976 14 None None None 153000280 Common - histone family protein DNA-binding protein Shew185_1755 205 COG0776 HimA, Bacterial nucleoid DNA-binding protein DNA replication, recombination, and repair 153002613 Common - hypothetical protein Shew185_4114 28 COG4222 COG4222, Uncharacterized protein conserved in bacteria Function unknown 153001756 Common - putative transcriptional regulator, XRE family Shew185_3247 9 COG3620 COG3620, Predicted transcriptional regulator with C-terminal CBS domains Transcription 152999917 Common - Succinylglutamate desuccinylase/aspartoacylase Shew185_1385 55 COG3608 COG3608, Predicted deacylase General function prediction only 153002530 Common - transcriptional antiterminator, Rof Shew185_4029 10 COG4568 Rof, Transcriptional antiterminator Transcription 152999777 Common - signal peptidase I Shew185_1244 210 COG0681 LepB, Signal peptidase I Intracellular trafficking and secretion 153000095 Common - hypothetical protein Shew185_1566 1 None None None 153001492 Common - hypothetical protein Shew185_2979 5 None None None 152999885 Common - hypothetical protein Shew185_1353 46 COG2933 COG2933, Predicted SAM-dependent methyltransferase General function prediction only 153000572 Common - exodeoxyribonuclease V, gamma subunit Shew185_2048 68 COG1330 RecC, Exonuclease V gamma subunit DNA replication, recombination, and repair 153000612 Common - prophage MuSo1, portal protein, putative Shew185_2088 25 COG4373 COG4373, Mu-like prophage FluMu protein gp28 General function prediction only 153002459 Common - transcriptional regulator, LysR family Shew185_3956 116 COG0583 LysR, Transcriptional regulator Transcription 153000694 Common - cytochrome c oxidase, cbb3-type, subunit I Shew185_2170 151 COG3278 CcoN, Cbb3-type cytochrome oxidase, subunit 1 Posttranslational modification, protein turnover, chaperones 152999756 Common - conserved hypothetical radical SAM protein Shew185_1223 91 COG1242 COG1242, Predicted Fe-S oxidoreductase General function prediction only 153001793 Common - Triose-phosphate isomerase Shew185_3284 217 COG0149 TpiA, Triosephosphate isomerase Carbohydrate transport and metabolism 153000704 Common - RNA-directed DNA polymerase (Reverse transcriptase) Shew185_2180 97 COG3344 COG3344, Retron-type reverse transcriptase DNA replication, recombination, and repair 153002154 Common - Purine nucleosidase Shew185_3647 88 COG1957 URH1, Inosine-uridine nucleoside N-ribohydrolase Nucleotide transport and metabolism 153001046 Common - 37 kDa nucleoid-associated protein Shew185_2527 31 COG3081 COG3081, Nucleoid-associated protein General function prediction only 152999598 Common - sulfate ABC transporter, inner membrane subunit CysW Shew185_1064 200 COG4208 CysW, ABC-type sulfate transport system, permease component Inorganic ion transport and metabolism 153000916 Common - hypothetical protein Shew185_2396 9 None None None 152999002 Common - histidine kinase Shew185_0452 169 COG4191 COG4191, Signal transduction histidine kinase regulating C4-dicarboxylate transport system Signal transduction mechanisms 152999683 Common - hypothetical protein Shew185_1149 35 None None None 153001367 Common - 3-oxoacid CoA-transferase, A subunit Shew185_2851 102 COG1788 AtoD, Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit Lipid metabolism 152998673 Common - hypothetical protein Shew185_0120 8 COG4319 COG4319, Ketosteroid isomerase homolog Function unknown 152998873 Common - transcriptional regulator, XRE family Shew185_0321 116 COG1396 HipB, Predicted transcriptional regulators Transcription 152999660 Common - type IV pilus assembly protein PilW Shew185_1126 20 COG4966 PilW, Tfp pilus assembly protein PilW Cell motility and secretion / Intracellular trafficking and secretion 153000833 Common - alpha-L-glutamate ligase-like protein Shew185_2313 18 COG0189 RimK, Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) Coenzyme metabolism / Translation, ribosomal structure and biogenesis 153001932 Common - hypothetical protein Shew185_3423 10 None None None 153002693 Common - histidine kinase A domain protein Shew185_4195 118 COG0642 BaeS, Signal transduction histidine kinase Signal transduction mechanisms 153001786 Common - ribosomal protein S15 Shew185_3277 215 COG0184 RpsO, Ribosomal protein S15P/S13E Translation, ribosomal structure and biogenesis 153001253 Common - exodeoxyribonuclease III Shew185_2737 197 COG0708 XthA, Exonuclease III DNA replication, recombination, and repair 153000621 Common - transposase IS3/IS911 family protein Shew185_2097 147 COG2801 Tra5, Transposase and inactivated derivatives DNA replication, recombination, and repair 153001584 Common - hypothetical protein Shew185_3071 3 COG1030 NfeD, Membrane-bound serine protease (ClpP class) Posttranslational modification, protein turnover, chaperones 153002804 Nonpathogen - cobalt transport protein Shew185_4308 3 COG0619 CbiQ, ABC-type cobalt transport system, permease component CbiQ and related transporters Inorganic ion transport and metabolism 152999614 Common - putative transcriptional regulator Shew185_1080 48 COG2345 COG2345, Predicted transcriptional regulator Transcription 153000177 Common - anaerobic ribonucleoside-triphosphate reductase Shew185_1650 94 COG1328 NrdD, Oxygen-sensitive ribonucleoside-triphosphate reductase Nucleotide transport and metabolism 153000806 Common - phosphoserine aminotransferase Shew185_2286 111 COG1932 SerC, Phosphoserine aminotransferase Coenzyme metabolism / Amino acid transport and metabolism 152999793 Common - hybrid cluster protein Shew185_1260 75 COG1151 COG1151, 6Fe-6S prismane cluster-containing protein Energy production and conversion 152999877 Common - exodeoxyribonuclease VII, small subunit Shew185_1345 115 COG1722 XseB, Exonuclease VII small subunit DNA replication, recombination, and repair 153001283 Common - ATP-NAD/AcoX kinase Shew185_2767 26 COG3199 COG3199, Uncharacterized conserved protein Function unknown 153001832 Common - lipoate-protein ligase B Shew185_3323 169 COG0321 LipB, Lipoate-protein ligase B Coenzyme metabolism 153002569 Common - LppC family lipoprotein Shew185_4069 42 COG3107 LppC, Putative lipoprotein General function prediction only